<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWL5</accession>
    <name>A0A913YWL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038044184.1">
        <property type="nucleotide sequence ID" value="XM_038188256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188256.1">
        <property type="protein sequence ID" value="XP_038044184.1"/>
        <property type="gene ID" value="LOC119718837"/>
    </dbReference>
    <dbReference type="GeneID" id="119718837"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="18310" checksum="3EA9631C0A4B18EF" modified="2023-02-22" version="1">MKPKKTVFVTVGTTSFDALVQVASSRQLCQQFQALGYSKVLLQIGRGVYEPEPVSKRGFTVEYYRYKDSIAEDIKNASLIISHAGAGSVLESLGAGKPLIVVINQLLMGNHQMELAYQLYLDGHLLYATCCNLLEVLSELDTAKLKPFPPGDTSKFSNFLDKAMGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWX7</accession>
    <name>A0A913YWX7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044294.1">
        <property type="nucleotide sequence ID" value="XM_038188366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWX7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188366.1">
        <property type="protein sequence ID" value="XP_038044294.1"/>
        <property type="gene ID" value="LOC119718964"/>
    </dbReference>
    <dbReference type="GeneID" id="119718964"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548316" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="9">
        <location>
            <begin position="675"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="816"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132309" checksum="7133FA7DC6C28DC4" modified="2023-02-22" version="1">MNGLKIRLFWFAVFMVIAFPEMPVSAVDLQIDVPTRPQCFGISTGQHFVLGFSDNHNTYSETRQLAILVVAFRNQQTSVTISSKYQIAGKPFQESFVVEAGGFTRTVLPSELVMDMTERSLKGIEISASSEVSAYGLMHQHFTTDGFLCIPTNNLGMQYVLVMGSSSFQSRFSVIGSEDSTLVQVTLHGRVTFEGKDYGVGELLSFMVDKLEAVQIEGETGQDLTGSIIQTNKPVAVFSGHECVTNPGSNCDTLTEQLLPVKSWGKKHIYTLAGSNDRNNYRIVAYFTETIVTIPGFGNQSLDTGEFWEGDLYGSGFVSSTKPTLMMQQLVNVNGALRDPSLIQVPAVEQFWFVFGFTTPPYSGGDSEGFFNFISIIVKTYARQTVYLNGSPINRTSVTEHNVPNTDYTSLTVQLPKGEGLYFVEQTDSQNPLSVIVYGYEERESYGYAAGLSLPSNKHVLSLTPYYLRELGGELLTMTVPCLQTNAISFQIAAKCKFATGFGDVIVSGERTDTYTVVCITPTFYKNGLTSVYVSLDDGGSFPYSGIVYVASEEDLPPLVQIQQVNSEYGDGIIDLTSDDPILFSWDPRILGEGVSHVTVMMQDTDYDSDGNPVLMEGVTVQSNVLNNGSLMIHPSDLQSLTSDGLSLAAFYLTPSGIRRRRNVGALLRRLRYYGPAAIIVTAITCEVSKYQLKKTAPTGLPPCPCNTGQADRDLNFQEANFANFFFHPGADNCYRSVNSLPTGAGQQCCYGKDGNILVGPPGGGTVDRYSPGDHFWKHQWFDVLPWLCLCKLSNNCKEYYKYRPSDDCSDYDPPRPAGGTGDPHLTSLDGYKFTFNGAGEFLMASSAVHNLTFQARMERYRNTNASVYTAFVLQVNDSSKVQVQMSNMNETLMLVDSEPLRLDSIPVKVHHLRGVRIRFNSDMTKISIAFSAGIAATVYMNTEVMSFIAQLDTHFQGQVQGLLGNLNGNPDDDLQFPNGTILEPGSPLKELHEFGLKWLVAPEESIFTYISPFDYSTYHFPKFSPTFEVPDLNQVSQEIMDLCGDSIDCVFDAVITGSLSFANETLVVTVTIAEVKKGLVKIVSCGYPGDVENGMVSGSVYLVNATVDVACDDGFTLNGSSRLTCLEDGQWSSDLPVCAGIKNGEKEGLAPGIIAGFVVGAVIAVLAICGLIYILRRRNMKRNKYKVVHTRNVYFSKTQPCSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXP9</accession>
    <name>A0A913YXP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044147.1">
        <property type="nucleotide sequence ID" value="XM_038188219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXP9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188219.1">
        <property type="protein sequence ID" value="XP_038044147.1"/>
        <property type="gene ID" value="LOC119718798"/>
    </dbReference>
    <dbReference type="GeneID" id="119718798"/>
    <dbReference type="OMA" id="ESHTERA"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="388" mass="42029" checksum="CF3D64827C40B12D" modified="2023-02-22" version="1">MGKLPLPVIVFDKQGVFSQGDFVSGKVKLKLDNEGLQNIKGVWVLITCKAKAEFGTGTATDDHEQEDVHINSILTVFGAGKRAPAKPDLSLPPGNHSFPFKFRLPTDKVLPSPFEGAYGHVRYRAKATLSIERMIFNKESHTERAFTVRGPRVDLNRLPKLNLKVPVSRCCEVRNLFGLGTKKGATVDFGLTKRGFIPGENIIVTGCVDNISGEEQRVIKVALVQETTYTVEEFLVNATEEHKKILCRSSRNISCPKGKVAKFSMNSLRIPIGCPSSGLPGCKLIDVQYYVECNTSGCIETSFRLTVGTVPIRSVSGPVPSVPTAEEATACTQPSAAHPMDKAKMAAPAPACQARPLRNGSVSRVDDAPPSYEQAIASGTTKENFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYL5</accession>
    <name>A0A913YYL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044829.1">
        <property type="nucleotide sequence ID" value="XM_038188901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188901.1">
        <property type="protein sequence ID" value="XP_038044829.1"/>
        <property type="gene ID" value="LOC119719447"/>
    </dbReference>
    <dbReference type="GeneID" id="119719447"/>
    <dbReference type="OMA" id="LYQMGHP"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15095">
        <property type="entry name" value="7tmA_KiSS1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="89"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="405" mass="45088" checksum="0E624C2955597485" modified="2023-02-22" version="1">MATASASSTTAQILGFFLSSTLTPLDTELTPSDSPPYLPANTTSSLAPRFPDIITEASESGPVQQATAGRAAWLIPVIFGLITVCGVVGNSLVIYVIVRHGHMKTVTNYYIVNLAVTDISFLLCCAPFTATLFVSPNWLFGTFMCKFVFYMMQVTGQCTCLTLTAMSIDRYQAIVHPIRSLKSRTTRVACIVNACIWIGSFLISIPVPIFFDLSLQPGDVWVCLELWPLQIMYPGYVVFCFILLYVIPIFTISVCYSLMLRKLWTRVSPGETADPNSGLHNARQKRKVTRMVLVVVLVFAVCWLPIHVITLWMRLDPAFPRTDPTYIFKMAAHTLSYANSMVNPFVYAFMGENYRRYFKKAFPVCFGQKRRRQAGDPTSRTDQNANFTGATSAAAVRTVETVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZ09</accession>
    <name>A0A913YZ09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 89</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044637.1">
        <property type="nucleotide sequence ID" value="XM_038188709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZ09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188709.1">
        <property type="protein sequence ID" value="XP_038044637.1"/>
        <property type="gene ID" value="LOC119719300"/>
    </dbReference>
    <dbReference type="GeneID" id="119719300"/>
    <dbReference type="OMA" id="AMLCSRI"/>
    <dbReference type="OrthoDB" id="10020070at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043450">
        <property type="entry name" value="CCDC89-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34768:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34768">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="77"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="40152" checksum="84A50F2F73A8F7DD" modified="2023-02-22" version="1">MASSSSGGRTSKELKMMISASNQDVDEMQGNLDKLKKLTKDDKTEAAMLRARIDEQSQLICILKQRADESLARSQTLERVNRDLEMFRDNAQEIIETEVKKSGLLERRFNELAENHEEMIRIKDDYKHKNEELRAENSRLRDENSRLFSAALVEKDGKIDSLQKQVTSLKEQCKELNQFVSRLQTEYHEKSQAMEGRIKHLEKQLNDTHKKLKGAQSQLQQQSDNLKNSDANHSLKLEKLAKEKDEMLELAMHRGKLIQDKQREIKDLQSKVAEAEREVSRMEDKFEREAAMVSTNLQVIRLKGEKDEAQHTLKQINMEYEAYKKHSSSLLAKERSLNAQLRNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z199</accession>
    <name>A0A913Z199_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044776.1">
        <property type="nucleotide sequence ID" value="XM_038188848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z199"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188848.1">
        <property type="protein sequence ID" value="XP_038044776.1"/>
        <property type="gene ID" value="LOC119719404"/>
    </dbReference>
    <dbReference type="GeneID" id="119719404"/>
    <dbReference type="OMA" id="FQMLWVW"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30494" checksum="9DCE30F2D6683B2F" modified="2023-02-22" version="1">MGTMFSSLRPTMHILARSAVVDFGIQWGLFIIAAALKTEKFYDLAGSGTFLLLTYLSLKWGETFHFRQMVQSGMVGVWGLRLGMYLFSRVLSEGEDRRFRHAKNNLGLFFIYWTVQAVWVWVTLLPTQILNAEKNDRPLTKRDYVGWGLFVVGFLLEIVADYQKAAFRANPDNVGKFINTGLWSISRHPNYLGEIILWAGLYISASSVMTGKQYLSVISPMFVYFLLTRVSGIPILEKYGMKKWGNNNLYRDYVNKTPVLWPKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2K9</accession>
    <name>A0A913Z2K9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045938.1">
        <property type="nucleotide sequence ID" value="XM_038190010.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045942.1">
        <property type="nucleotide sequence ID" value="XM_038190014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2K9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190010.1">
        <property type="protein sequence ID" value="XP_038045938.1"/>
        <property type="gene ID" value="LOC119720355"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190014.1">
        <property type="protein sequence ID" value="XP_038045942.1"/>
        <property type="gene ID" value="LOC119720358"/>
    </dbReference>
    <dbReference type="GeneID" id="119720355"/>
    <dbReference type="GeneID" id="119720358"/>
    <dbReference type="OrthoDB" id="6051775at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275586" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19287" checksum="25B2624D7C62A876" modified="2023-02-22" version="1">MYFFKVFGIVAITSAINAQFGSGTCRSRLARECSCPPQWQLSGEDCYRLTPSPHTWDDAKSACQDIGGKMAAPRSHEEMNFMADMARELDSKYKAWIACNDKEVEGFWECDGQEGSAPFLGWGSGQPDNGGNIDCATIRKYDGKMDDSHCWKAFRAVCVRRAACTHGLIQIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3J6</accession>
    <name>A0A913Z3J6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045280.1">
        <property type="nucleotide sequence ID" value="XM_038189352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189352.1">
        <property type="protein sequence ID" value="XP_038045280.1"/>
        <property type="gene ID" value="LOC119719883"/>
    </dbReference>
    <dbReference type="GeneID" id="119719883"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="94" mass="10981" checksum="98B8F338F9A02EE6" modified="2023-02-22" version="1">MKRPLISQKKNVARSGGPRRSFFLLVWAKRSAWEMCGVFLTSASRMEVVVYFTALFPYVCLFVLLIRGVTLPGYQKGIVFFFRPKWESLMIPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z487</accession>
    <name>A0A913Z487_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046532.1">
        <property type="nucleotide sequence ID" value="XM_038190604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z487"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190604.1">
        <property type="protein sequence ID" value="XP_038046532.1"/>
        <property type="gene ID" value="LOC119720769"/>
    </dbReference>
    <dbReference type="GeneID" id="119720769"/>
    <dbReference type="OMA" id="YWLAFVN"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="651" mass="72969" checksum="83233070169E8488" modified="2023-02-22" version="1">MMAESGNSDIPIEARPTWASKKEFFLACLGWAIGLGNVWRFPYLCYENGGGAFLIPYFGALFLAGLPTFFLDLVLGQYSSLGCISVWRAVPLLKGLGFSQVVYSFIVGSYYNVVITYSVFYFFASFTSNLPWTGCDHEWNTALCSSLVSDCLGADGVITFNNTCQKLGNLTDQELESLNVTMTGDEDYDVSNYTDPLDGLRRSSSEEYWRFAVLQESPSMDETGGVVWQLALCLLFAWIVVFLCVAKGIKSSGKAVYFTATFPYVCLFVLLIRGVTLPGYYKGVEFFVTPRWNTLTKPKVWLDAIGQIFFSLGSGSSGTLTLGSYNSFHNNCLIDGLIVPLINSATSIFAGFVIFSILGYMAHTQGKDVSDVVSQGYGLAFVAYPEAVSRMPLAPFWSALFFFMLFIIGLDTQFVIIERSVTGLVDEFAFLRRHRLLTLLVWCLAMFFVGLIFVTNAGPYWLAFVNAYAPSVALIFFVAGECLAISWLYGIRRLLNDIRSMIGDKVVDFPLFKLYPFAWAMIVPLFLLIVVVFKFITRTEPQYNGPLPAWSAGIGWSIFIVVLVWIPLWWIYAMMTEKGTLKERLQQLVRPRDNWGPALPENRLHAWQVHRRLGTSMGGKLNPDSKGLQKRDDEMQVKYSSLPDQIENNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4Q3</accession>
    <name>A0A913Z4Q3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038045720.1">
        <property type="nucleotide sequence ID" value="XM_038189792.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189792.1">
        <property type="protein sequence ID" value="XP_038045720.1"/>
        <property type="gene ID" value="LOC119720204"/>
    </dbReference>
    <dbReference type="GeneID" id="119720204"/>
    <dbReference type="OMA" id="HKIDFKK"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1246"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="1637"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1836" mass="203903" checksum="E7DCA93189A03700" modified="2023-02-22" version="1">MAAFNQPQKTSVFVRAPPIGSDAQQSAFRDTLWIYFQKKRVSNDSDVQDVCVLSSDDEALWLKVTFNGPSGVNAVLAKEHHELIWGKETLPLQVQSFFPGSGFAAPPVESDLDIEILNWDDEFGASTGGAWRAESISDRSLSSRHEGNPFGRSAGWRSHQASCYEKSTHTPHHARDPFEPCLANSPAPSPMAPVTASPSTAPLKAPGHLDGNSARDKSAPSALQMGLRERVPGTAVRTTLTREHKPVPAEEEGKRDNQGQEEECVHIVEVTSFKSTTSEEMLRLYFESPRKSKGGEIETWEMDAETGTIRIKYSNPSVARAVAGKTHKLGGVKLSVSLFVKRKTRPRPVKKQCLVLRGIPDGCPMEHVELYLENCSGMDEPIVKYGEKPGTALCTFAQDIPDLQKVIRKVCSKKLQKARVTAEVVHESDCILVQGLTDKMSLEFIELYFDNKKKSGGGGVREVLIGSAEDQAIVYFEDWKVVADVLSKKGPHKVGSAEVSVEEYHDCLGRLSELDVPTPHTPKPISVQVPQDIMEFIFGAKGKHTKKKLVVELKQVRALLHWPDGDKKTAARLEPIPEDGQRQYSWLNWSQRCDEVLTGFLNRCKSTAVDVPSSLWKEASTKLAKVKATHICSDLDDQTHSVQLVGEQQDVNAAAADIMVLIKELQAKADSDAQPTKEEIVMPPNELKIFTQCGIHRKMEQMFPDLKITIASFQGQMGLILEGTRKNVVEAELWMRRQMDGLNRMEFQTGRGKTAIIRDVSDKIHEIFRSKDINVACTISADGKIMIYGSSEKDTSQAKMYIDQEIEEDVIRINGPAVIAVLKSQDGSQLVAGINKNVFVKADINYHSGNIELAGFRHELKGTKKHILAFLKDTVKVKGTIRTNRSKVRMINTYNGQELTDFMAKHQRDQVIIQPQMSGHNVGFLVEGNEEGMDAASQFISQLVAGIKEKPYPVSKIAMVQLFRETEGKKFLESIERELECVIDVIGENENDDEQSEGARGIWGPDDEPVAVPTKFTYFGPNIVTTNEGIYVTLKKGSITDEKADVIVNTAGSDLNLDFGLVSRAILQAAGDALQQECDKAIAVRGKVPSGSFVETGAGKMTNCKKIFHCVIARYHSNASEKSLGTLVDSLLQQADIIKACSLAIPALGTGSLDYPADVTARVMYEAVAAFSSKHPTGVLKDIRFVVYDKDVKTIKGFEAEIERLTNVASGGAAPAFTRRKLRKSILTSAAAHRHSYSQTQKDMDGTLHSKIGENPVRLQICQGDLVKEKGSAIVNIVGEKLDLQGSLSGALLAKGGKTIRKQCDVLRKKNPTKLVYVTKAGKLQCDFIFHVITPKTTEEIKIIVTKTLLEAEGKQVQSISFPALGTGQQGRIAVCPSASAMLAAIGEFVCREKPRHTLLVRLVIFKPEMLPDFETALRQAEGRSYKKQASLLSRSSGRAKSFLPGAAAETQQETIPLHIFAMNDATIQRATDKIDRYQDEEFTSEDMPDSLGIIAKMNEEHHDELRNIEREYNVHIEYFKGHAKFLRVQGRTINVKDAIFSIQEWFTRMQVQETDKQRSEHLTKEVLWQYNTPTGVEDYEADINAIIEDAYQRKQPSVVLDLEDGWFTIDFRKMEEQSTAGAFSVNRVDLQQDATLPTSWIPMRKGEHFQLVKLAVGSKEYTDVEKRFRSSMGPKAPVNQIDEILRIQNKDLMMIYQARKAAMEARLDRTDIEKTLYHGTDEQTCDKINRFGFDRGFSGKNATVHGNGTYFAAEASFSARSFYAEPNASNTKHIYATKVLVGDFTTGAKGMVMPPNKPNNSDQLYDSVVDNVGKPSIYVIFNDAQAYPEHLIKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4R2</accession>
    <name>A0A913Z4R2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholysine phosphohistidine inorganic pyrophosphate phosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038046813.1">
        <property type="nucleotide sequence ID" value="XM_038190885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4R2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190885.1">
        <property type="protein sequence ID" value="XP_038046813.1"/>
        <property type="gene ID" value="LOC119721020"/>
    </dbReference>
    <dbReference type="GeneID" id="119721020"/>
    <dbReference type="CTD" id="64077"/>
    <dbReference type="OMA" id="EEHIFMP"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07509">
        <property type="entry name" value="HAD_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000051">
        <property type="entry name" value="Phospholysine phosphohistidine inorganic pyrophosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF44">
        <property type="entry name" value="PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="286" mass="31214" checksum="C893491985142CEA" modified="2023-02-22" version="1">MRRCVTHKLIIKLIMTSRGDDWSSNLQGVLLDISGVLYDSGEGDGTPIAGSIDAVKRLKSSGLKVRFCTNESQCTRQYLVDKLRRLGFDINLNEVFSPAPAACQLVRERKLHPYLLVHPDAVPDFSEFDLELTPDCVVIGDAAVSFTYERLNAAFRVLIGQENPVLISMGKGRYYKETDGLMMDVGCFMAALEYAAGCKAEVVGKPAKGFFLGAVKDMGIQPQHAVMIGDDLVNDIGGAQSCGIKGVQVRTGKFRPSDESHPTVKPDGFVDNLAQAVDFLLKDHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5G7</accession>
    <name>A0A913Z5G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adipose-secreted signaling protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADISSP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046251.1">
        <property type="nucleotide sequence ID" value="XM_038190323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5G7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190323.1">
        <property type="protein sequence ID" value="XP_038046251.1"/>
        <property type="gene ID" value="LOC119720591"/>
    </dbReference>
    <dbReference type="GeneID" id="119720591"/>
    <dbReference type="OMA" id="GVRCIGM"/>
    <dbReference type="OrthoDB" id="6246153at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026794">
        <property type="entry name" value="ADISSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287:SF2">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15006">
        <property type="entry name" value="DUF4517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="22908" checksum="39896492B2D9FC80" modified="2023-02-22" version="1">MAAADCSTLTAPSVSTEQPVVEMETDIAKVVVEETTIIEEDEDEEDKPRITRPRGSSRVHFPEDVHDPEIHVSRENNASIDVNVGFLQCSHRYQVCFTVGDSIKGEVDIPLVDKSTGVLSAEAFPTQNGDGHDVTIQLLNHKDGVVSEDIELVSRTEPSKTVKVVLHCRFINPGKDQGTPQVKEGVQTLCLEPDPSAEESEGSDWTPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6M8</accession>
    <name>A0A913Z6M8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046666.1">
        <property type="nucleotide sequence ID" value="XM_038190738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6M8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190738.1">
        <property type="protein sequence ID" value="XP_038046666.1"/>
        <property type="gene ID" value="LOC119720872"/>
    </dbReference>
    <dbReference type="GeneID" id="119720872"/>
    <dbReference type="OMA" id="GCINRNC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="290" mass="29238" checksum="059108C1FF11B061" modified="2023-02-22" version="1">RTSQTTPEVATTGRSTTVADRTSQTTPEVATTGRSTTVADTAAQTSDIGTTSVLTTGIETTLAKSSTEALSTRTSQTTPEVATTGRSTTVADTEALSTRTSQTTPEVATTGRTVVAETTTPAVTTSAEVVAETTTPAVTTSAETTFAESTTTEQRSTTAAQRTSQTTPEVATTGRSTTVADTTVDVETTIAAETTAHTTSPAHTTVIGTTIAAETTAHTTSPAHTTPAVTTSAETTFAESTTTEQRSTTATSQTTPEVATTGRSTTVADTTVTTSAQTSAGASTSLGITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z767</accession>
    <name>A0A913Z767_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047567.1">
        <property type="nucleotide sequence ID" value="XM_038191639.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191639.1">
        <property type="protein sequence ID" value="XP_038047567.1"/>
        <property type="gene ID" value="LOC119721558"/>
    </dbReference>
    <dbReference type="GeneID" id="119721558"/>
    <dbReference type="OMA" id="DRWVKAH"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000034">
        <property type="entry name" value="Titin isoform A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000127">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="88"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="291"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="392"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="493"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="594"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="695"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="796"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="892"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1287" mass="139737" checksum="AA48CA9910F779CC" modified="2023-02-22" version="1">MTLTWTAPASDGGSPITGYIIEKKDRFSSRWLKVKETSITETVYTVVDLKEGTEYEFRVSAENKAGVGKPSEASDKTVAKPPYDAPGAPGIPEISDVDSTHMTLTWTPPTDDGGADILGYIIEKCDADRKRWVKAHKEDMITDLTCTVADLVEGTSYMFRVSAENIAGVGESSEAAGPQKAKPPYDVPDAPNSPDVSNIDKTSVKVTWSPPEHDGGAKITGYVVERRDVGRDRWVKAHKTPLMDTSFTATDLIEGKEYEFRVSAQNKAGVGEPSAPSIAIKAKLPYDVPDAPLIPKISDVTESSMKLDWTAPKSDGGDDITDYIIEKKDRFSPRWTKAAQVQATETSCIMDGLKEGNEYQFRVIAANKAGPGKPSDSSKPTVAKSPYDVPGTPGAPVVSDITATSMTLNWSPPQSDGGTPITGYTIERKDKFSSRWSKITKEPVAETTFKVTDLKEGEEYQFRVTAENIRGPGKPGDACSFVKAKPPYDLPGKPSAPKVTDVDSSHMTVTWSPPESDGGSPITGYILEMKDTSSTRWAKVSRESISETTFKVKDLKEGTEYEFRVTAENKAGAGKPSDASKAQVAKSKYDVPGAPEKPTVSEITAVSMTLTWSPPDSNGGSPITGYVLEKRDISSKRWLKVSTETITELTFEVTGLTQGSKYEFRVSAQNKAGTGKPSAPSDVNEAKPPYDVPGAPGKPELTNDTETTIHLKWSAPKSDGGSPITSYIIEQKESFARSWTRVLETKMTNVECTVSNLKQGSEYQFRVSAENKAGVGSPSEPSNPIVAKLPYDVPSPPENVKLSPVSPTSIQLTWSAPSNDGGSPITGYYIYQKDAFSSRWNKITSEIIEETSYKVKSLADGSEAAFHVTAVNKAGESKPSESVALKIQPPGAPEAPEIEKIDNKFAVVTWSAPDNTGGSPITGYQLEKRDTAKDRWVKVTRGAIKETTFEVKDLVKDAVYEFRVAAENKAGIGEPSQPSKRAVAKLPYDVPDAPSKPEITSVNKTEMTLTWNPPGSDGGSPITRYILEKKEPFSSRWSEVIKVTETEFKVTGLKEGTEYQFRVSAENKAGVGKPSEPSESKVAKLPFDVPESPKNLAITDSKPTSLTLSWSAPDSDGGSPVTGYIIERKDKFSSRWTRVNTASIQETSFNVTGLQEGTEYEFRVIAENKAGSSKPSDSVALKIQPPGAPEAPEIEKIDNKFAVVTWSPPDSTGGSPITGYHLERRDTAKDRWVKVTRGAIKETKFEVKDLVKDAEYEFRVAAENKAGIGEPSLPSKRAVAKLPYELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7J6</accession>
    <name>A0A913Z7J6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047659.1">
        <property type="nucleotide sequence ID" value="XM_038191731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191731.1">
        <property type="protein sequence ID" value="XP_038047659.1"/>
        <property type="gene ID" value="LOC119721772"/>
    </dbReference>
    <dbReference type="GeneID" id="119721772"/>
    <dbReference type="OMA" id="YLIRINE"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF1">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="620" mass="71372" checksum="1AD6F234295055F8" modified="2023-02-22" version="1">MDVQPGHCWFCEKPLPQRTVSCSRCPVAVYCASSCRDRDTVRHGAVECEIFQAKKCSACGKLGKTLECSGCNDAWYCDTDCQLHGWPFHKAKCKEIMAFVKQVSLKLNTSRHGDFPFYIGNTMAKDFLQLENNELSTDRVDKEELTRDYHVLSAGCGNLRNTVLTAASLPDEYQGKLYITLNDYNPFVTARNVLFLFILVRFADTDYIASSLTTIWYSLYISKREFDLIKTSLDELIQMSAQQLHDATKGLVTVLDENLSYLKFVWGKWRALQCHRDKKTSINLKQQRKVLFDNCHFAKVNHPLYLIRINEKDRKMVEEWFEHGLFFPYEAKEKNMPFGNPTLTAPKASKTIAGEDARLFLLLNNTQAVSQEDATFEYCIRPAIIPFEEWDCLRVREHTPGSHSSPMVMYHKYVTNLLQKVKSLILQGRLLIHVSLADSLDFPNHHQTLNMPNYDRIFTSNLADYVGFAKLLQTFKPLLNSSNSYSAIVTETMNWFEAVPGSKPAPYDLSDIQLAKINYYCSNSMTGIPQIQHTWMYDYFNNTSHFLQYLRADIMAGGRGIPALKKIPSFQNVKKYHGMEMRDFRKGLNKLVPFQYLVNKRDLNVNNSLDRAVEWCLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8L6</accession>
    <name>A0A913Z8L6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047346.1">
        <property type="nucleotide sequence ID" value="XM_038191418.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191418.1">
        <property type="protein sequence ID" value="XP_038047346.1"/>
        <property type="gene ID" value="LOC119721364"/>
    </dbReference>
    <dbReference type="GeneID" id="119721364"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000053">
        <property type="entry name" value="Importin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1032" mass="119041" checksum="C54F9990295EA09B" modified="2023-02-22" version="1">MDQQNLVQILQGSIHPDTREEAEKQLDEVHKIIHFSPTLLRVVMDEGIPFPVRQAGVIYLKNMVNQFWNLREPDSPLEPIPFSIHEDDKSVVRNNIIEAIIATPDLIRVQLAVCLSVILRHDYPGRWDSVLVTMTNYLSVDNPATLYGALTAVYQLVKNYEYKKPNDREPLHLAMMQLLPVIHHRCVQLLQDVSDQSLLMQKQILKIVYAMIQYDLSLDLINREFFKFADWMEIMQTIVSRPIPESTLQVDIDDRPELPCWKVKKWALHFLARIFERYGSPGSVVKEYVKFSDWYLKTFSASTLKVLLSILDQYCKKVYIAPRVIQQTLSYINTGVSHAFSWNFIKPHIQPIIQEVLFPLMCYTDEDDELWNEDPYEYIRIKFDAFEDFISPVAAAQTVLRSCAKKRKQVLQKTMGFCMQTMTTPGVEPRKKDGVMHMVGTMADILLKKKMYKDRMEQVLVSNIFPEFNSEWGYMRARANYVLHQFCEARFNNERNLMTALDLTRNSLIHDKEMPVKVEAAIALQELITSHEEKAKDFIKPHVKDILQALLIVIRETENDDLTEVLQRLITTYGDEIIPIAVDITQHLAATFSQVIDSEENMDDRAATAMGILNTIETVLNVVEEKQEIVVQLEGIVLNVVAVVLQNNLLDFYEEVLQLIFSMTCTHISPPLWQVFEMLYNTFEQDSYDYFVEMMPALHNYITTDPPAFLSSHRHLEIIYNMCKKVLEEEAGDDPESHAAKLLEVILLQFKGEIDHCVPLFIEVVMTRLTREVKTTELRQMCLQVVVAALYYNPLLLMETLEKMTIPNTNEAVTTQFIKQWLHDTDCFLGLHDRKVCVLGICTLVSLPNLPPXVIECAQQFIPALLLLFGGLKRAYECRAIVEDEESEEEDDDSDYEEQALDSDEDEIDEENAEYLEHLERIAAGREIDEDEDDEETVLEGFNTPLDDEDGPFDDEYMLFKTVLTNIQASNPSWYNALTSHLTVEQQNDMQEIAKTADQRKAAADSRQIEKQGGYKFQAPNVPKSFNFGSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8S3</accession>
    <name>A0A913Z8S3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Armadillo repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with mitochondrial contact site and cristae organizing system (MICOS) complex components IMMT/MIC60 and MICOS10/MIC10. Interacts with mitochondrial outer membrane sorting assembly machinery (SAM) complex components SAMM50 and MTX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047406.1">
        <property type="nucleotide sequence ID" value="XM_038191478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8S3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191478.1">
        <property type="protein sequence ID" value="XP_038047406.1"/>
        <property type="gene ID" value="LOC119721406"/>
    </dbReference>
    <dbReference type="GeneID" id="119721406"/>
    <dbReference type="OMA" id="VTRNKFN"/>
    <dbReference type="OrthoDB" id="17335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016617">
        <property type="entry name" value="ARMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46840:SF2">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013899">
        <property type="entry name" value="UCP013899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR013899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="280" mass="31238" checksum="92F5F2747B265891" modified="2023-02-22" version="1">MDVCAVVRQLRQLASDQKNREAIVKDQGCLPGLVLFLDNDDVSVVVTALETLQLLADCPSNRPIMKKELGMLISLQDIMDKSKYGVRAQNLARDIYGTLTTPPSPSPLKETQNTTQHKPSTKPKDNKAFFLGSNNKKGKVVMLQLNGLNDQAQRKACEEELLKVKGVISFTFDLFKKRCILRTKAELRPELLVAAVARTETVSAKQIIRNEYGEEVLLSFGADPGTADKENRSRPDYLPEDDSPVKGLDKAMVRQGQMDQQQKSSWLSTAASFISTSFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z954</accession>
    <name>A0A913Z954_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048277.1">
        <property type="nucleotide sequence ID" value="XM_038192349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z954"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192349.1">
        <property type="protein sequence ID" value="XP_038048277.1"/>
        <property type="gene ID" value="LOC119722304"/>
    </dbReference>
    <dbReference type="GeneID" id="119722304"/>
    <dbReference type="OrthoDB" id="6431796at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="552" mass="63982" checksum="BB798DCACB24CBC5" modified="2023-02-22" version="1">MALFDNHLMRALLLRQHHYGHWLDLDGDTAAEILEPMQYLQYLHYNNVRNSRLEEDDDSSEDTDQEDDFNPATHLCQQLASYFNNSKFSDITLKVRGNTFRAHKLVLCTWSDAFQEMFVGSKRRTTSEGSITDEGASGEVQFEECTLAESEECSKVFGDFLKFMYTETVELTDNNVYPVFELAKKYKVQGLCDVCQEFLVEKVSYDKMAALKTLSKAEECGMTKLYRHCFSVLETNFEFLEQSCILDMSPSLFLKLLRSPNLVVSFELLALLLAFKWLTVKGKEERRRYTEEVISLIRFPHISPVSFKTISGKLLSCPKMYPSFKHLLQERIHRVYEWKLLASEEEFRQLPYHMRFAAFARNCVAMRYYISEPEENYKRLTLLDEKVRSRQGKSNEVTKTGLGVPSVWVIGVTANNVHQVEESDWLVDGVAFYDKTCERWGIRYHIKPSAEAHARHQHRDYRLVILTILPGSNCRRPKVHTSEGIVPPVGSSQTIMVKLPPRLMGLKEKPAHVTVRVSLFIKVKRSQMLNVRLFTPTELLQQKTFTHGIFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9K2</accession>
    <name>A0A913Z9K2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048458.1">
        <property type="nucleotide sequence ID" value="XM_038192530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9K2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192530.1">
        <property type="protein sequence ID" value="XP_038048458.1"/>
        <property type="gene ID" value="LOC119722421"/>
    </dbReference>
    <dbReference type="GeneID" id="119722421"/>
    <dbReference type="OMA" id="RIADHKV"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="53041" checksum="E7AA5A35F397DD01" modified="2023-02-22" version="1">MIGAHHHDQQRRARAGSFDRFIPVRDGASLAAASFKFSSRRSDDVGATSAQDVFDGSAGEAGEANNNDSPYKQYRESSSDYLQRMTLLTDRVTEDSILSFRPRQRSGSWSGYRDAETSKQPCRQLPSSPAQTFYVTGLNGTSDECSRLFDINCHGQLAIPQGDAIHIKELTRPDQTFEPFSLHITKPITGRDAGQLHRQRRWCVQWSSTGHTLAVGGPALMLIDATLGDVTASIMTSSPPSCLDWSRHCLSAGFLDGAVQAYDTRIGLCTVGSFICTSRHSSPITTLRYSVDGGLLACGTADGKLVIWDTRQRQKPQHEMEAHSDGVGAMAWCPWKPWYVTTGGKASDQTIRTWNAYSGVMSKNLMVGSEVTSLAWYEQSSELVSSHANPSGEANIRVWKSPKMRMIVELKRHEGPVLQVGLTPGGDKLASVGSEDPVMLCIWDFSTGYPLSPQGASSHPRRRSSTFNSPGKSPGPIASPLALGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9M1</accession>
    <name>A0A913Z9M1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047585.1">
        <property type="nucleotide sequence ID" value="XM_038191657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9M1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191657.1">
        <property type="protein sequence ID" value="XP_038047585.1"/>
        <property type="gene ID" value="LOC119721579"/>
    </dbReference>
    <dbReference type="GeneID" id="119721579"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517956" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="20408" checksum="25BCB14526764BE1" modified="2023-02-22" version="1">MAALRDIFVVFLFALGGFSFLSALCPPGWKNWHQSCYAMYFDEMSWADASEFCESKHSHLVVPNSQAENDFLWRMVMERFRTVDKRGVWIGCKREPVNASFVCRGNTEGMSFTNWATSYPKQEDRQCVVLWQEGNGTWRSINCMPNIGRYVVCEMQDTPRVRCLTADSNGRFVSDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA93</accession>
    <name>A0A913ZA93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047926.1">
        <property type="nucleotide sequence ID" value="XM_038191998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191998.1">
        <property type="protein sequence ID" value="XP_038047926.1"/>
        <property type="gene ID" value="LOC119722022"/>
    </dbReference>
    <dbReference type="GeneID" id="119722022"/>
    <dbReference type="OMA" id="HTTEECN"/>
    <dbReference type="OrthoDB" id="10066002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="294" mass="34488" checksum="D25EB9D2116CC088" modified="2023-02-22" version="1">MAKTKRITSQRLNGSKIMWSLLTRYRSTWRYMYVTADYQRDWIKNKERTVAEILQEFPRLLDSNMIEEDYRLAYPLSTDSLYNRWSAMVDPIIEYGTRMCPLWKETLELPQDMTLDKLTKDQKSILALIIVPVVFEGNSKKRAAGRSTIKDVVGFFIDRYWDIINMPQYLKEVDPKTHPQPFVLSLSSAIHLESRNAFIIIEKQAIPQPSILKAVDVCYKAHYILDCEYQGAWTFFEKCVYQSQCFAERRMGLPCTQKCSLNTAADVQCTQHVFSCIFKATRRVWISSRCFNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBH6</accession>
    <name>A0A913ZBH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038049133.1">
        <property type="nucleotide sequence ID" value="XM_038193205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193205.1">
        <property type="protein sequence ID" value="XP_038049133.1"/>
        <property type="gene ID" value="LOC119722842"/>
    </dbReference>
    <dbReference type="GeneID" id="119722842"/>
    <dbReference type="OMA" id="DGLWGYY"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203143" description="Hyaluronidase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="449" mass="48922" checksum="8EE0C8EE29EE3987" modified="2023-02-22" version="1">MKQITTSARQQGMNKMQFLAQWLLLILATGNICEVTPLTPRGRVAGIVGLSPGKEPGPSPLPPALADRAFTAVWNVRNSHRCLTKFGVDIDLGSNGILTNSPTGNDVMVYFGHEDLGLFPYIQRGHFVNGGLPQLVNGTAHLEKVAVDIRTAIPDANYSGLAVIDWEFWSPVWNKNIGVPGSELYNAESMALVRRRHPTWDQGTVEATAKTEFEEAARSLYEGTVLLAHQLRPKALFGFYHFPYCNNHADARYCNQTSVLSNDQMSWLTDASPSLYSSIYMKEEDTRTDTAVYIDTILQEAVRVRQNSKDPNKPMYSYVALNYSHTGLFLNLEDMNNSILLPAEQGLAGVVFWGDNNDTSNRAACLGLQKDVKLALGPLVLKTTQAAARCSASLCSGNGRCVGKILECISGAPSGVTPGRISKFGAKKSSACRCQCYNGWSGTNCSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE01</accession>
    <name>A0A913ZE01_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049714.1">
        <property type="nucleotide sequence ID" value="XM_038193786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193786.1">
        <property type="protein sequence ID" value="XP_038049714.1"/>
        <property type="gene ID" value="LOC119723224"/>
    </dbReference>
    <dbReference type="GeneID" id="119723224"/>
    <dbReference type="OMA" id="MENMFAS"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="435" mass="48418" checksum="D2014BB35CC8F1DD" modified="2023-02-22" version="1">MENMFASNATPEYEWDAQRLNVNFQYTFLLIVEILVFLLGVPGNCLILRVYWTKTRKTSTDILIRALAWADLVVCLLSIPAIIVWSLFVFGKFLPYSFILALIDAVINALTDAAIVSSFSITAVIAVERCDCVCRPHKRIFNPRRSKMAVLVAVLFAIAINAGQLTLDICFITSGTEPPSLQVYGKIVEIVELVLFVTALVTMGACYGKVYVTIRKHVKVGPAQAPTARDAERSPSDLRVGRQANCSTRPTPPQQNIDLATSESFVDEAVTRFVHPPSTSSSMHANSYQAKPNDVCTAAHVVSFAHQDSSGPSQPNVIPEPKTAAQDNTPSQRQSRQEQGHAPQRVGAAKLQRKTTRMLFITSVVFLLTWIPYLVFTVKYYATPYSDDFEEIIGAISIILLINSVVNPLIYGIANRRFRSDCKEVFREIKCFKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE34</accession>
    <name>A0A913ZE34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049220.1">
        <property type="nucleotide sequence ID" value="XM_038193292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193292.1">
        <property type="protein sequence ID" value="XP_038049220.1"/>
        <property type="gene ID" value="LOC119722894"/>
    </dbReference>
    <dbReference type="GeneID" id="119722894"/>
    <dbReference type="OMA" id="ANSWRFA"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="17"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="468" mass="49560" checksum="22278011F9079903" modified="2023-02-22" version="1">MATVSPSYREGGWGWAVVLACFMTEFIICGNLKALGVLITYMKEDFGTELWVVGSIVSLHYAVQSIMCPLAAALAPKFGVRSLVLVGSALYGVGLVVSALTHSIAILALALVVIAGTGVASVLEITHAELAYYFREKYPLAAFLTFTGTPVGMMLLGPITQVLVDTYGWRGAMLLLGGVSFHLVVAGMLIRRPPNSYQAVPDHEEQLTIDGIDSPGKFKQEVKLNKSKISNLWNSVFSALGLEVFVSAEFMIVATIRMLYSIGYGGVVVYIVPNGLALGLSAKEASFLTTAWGVGNLAGLILLASAMHVKLVSVRRAEGIAVSVIAVGFALEPFVSPFVGQILTAFVVGAGLGCAIEGIFVMTRCLPFGDDKFVSVLGWQTFLSGVAAAIGDTLSGWLSDATGSFHATFFLYSATMAAIVLCLLVDAIRISSTTGSSKQRGPAVLMPSLFKKDSSTSFERVPIQPNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF26</accession>
    <name>A0A913ZF26_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049666.1">
        <property type="nucleotide sequence ID" value="XM_038193738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193738.1">
        <property type="protein sequence ID" value="XP_038049666.1"/>
        <property type="gene ID" value="LOC119723180"/>
    </dbReference>
    <dbReference type="GeneID" id="119723180"/>
    <dbReference type="OMA" id="FWRANLT"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124073" checksum="CEFBE284D67493E6" modified="2023-02-22" version="1">MINDAVVRKKPNIGVNLRRQVVCVHQKQKMSQDCSLRDPRDHFSPVGRFTLQHDLLMTIDSDNQTLSWTRMCSTGRLSVPDVCMTVVEQTTLEESNSGTFLYDAKSILSLWNIFWRANLTCHAHVNGDPKVKFDDLWHTAEQLSELLDCLFETECQNLALECCKFALRCGPVNLLQALFNNKLIDLHVNHTFDDGKSLLHYACLSSNVKAVAFLLSRGASLKIVDNAGQTPDQLCFCSYTRKELPSRYQTSLRMQKKQVASFEEKSHIFELVSDSESFEDLQIMLHTLEFDVNRDKDSLGNLLLHRAVRQGMSHLALVLNLVLVHQADVEATDNKGMTPLCIAAHLGDEFMVEVLMCVLGADPNAVCTLNHWTPLHFAAKKNILPVIECLVRRGADLNVEDMFGFRADDIAKKVGNLECQDVIENLRVQRCQKLSCLAKKGNLTPKVIFPSDIYTVDSEGLTLVMIAAKANRCDNLMVLLHNQKCPIDAQDPKFGQTALSLAAMLGKADAVQTLLRYDAHPGIGDIHGMLPLHHACLRGHVLCVQMIVNVSKGLTGLLEAMKYSDNPEICSIIQEATHRRQRNLVNPSLFECAMNGDADRLYSTLEEGDQVNPLTGTGDWPMYMAVGNRYIKVMQLLLANGGDFWSQHQTTGSTVLHIACSRGLYDIVSYLLWFSATTRKGCSPIETGDGYHCENEQLNIDAVNHLGFTALQVASTKGFSRIVKLLLSHGASSALVDSQGQLYKCCEFEGVQVLIEHHQRRRAEQIAAYIKGTRGVHQLIKVWQAKFDHNLRSRSGDTPLMVACLYGKVEAVKFLLRSAIQFVGKTDMSVQRRGGQNDCFVDSGAYDGAHPGCYSSPDRSLQTVDEYSAEMDTRSSVSNLSDQDDRSHESMKKQYNTHPSNLKGFSSSIDLHSKHVRRQTQFTKSCGFDSESLDDSENEAYAGTFNKHTDKSTVLYSQRAFSSSDIHSLQSANELSHKDQVSSRHGSLQTSSSRLFQGTHVNHLCAINIRDGCSAMHRAVECINERRGLEILLLLMDKDSSIINIQNVQGLSALHLAAKLEKAKIVKTLLSVQCINPNLRSSNGKLAEDMTRSKQIGHLIRDARQKLKEQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFZ7</accession>
    <name>A0A913ZFZ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050354.1">
        <property type="nucleotide sequence ID" value="XM_038194426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050355.1">
        <property type="nucleotide sequence ID" value="XM_038194427.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050356.1">
        <property type="nucleotide sequence ID" value="XM_038194428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194426.1">
        <property type="protein sequence ID" value="XP_038050354.1"/>
        <property type="gene ID" value="LOC119723651"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194427.1">
        <property type="protein sequence ID" value="XP_038050355.1"/>
        <property type="gene ID" value="LOC119723651"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194428.1">
        <property type="protein sequence ID" value="XP_038050356.1"/>
        <property type="gene ID" value="LOC119723651"/>
    </dbReference>
    <dbReference type="GeneID" id="119723651"/>
    <dbReference type="OMA" id="FLVEWRR"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="18"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="609" mass="65274" checksum="85F9A7187069A0FA" modified="2023-02-22" version="1">MAVKHNSPVPPDGGWGWVVVVGSSVSLHFALFIRCIGVFFNEWRQFFDASATAVGVVGSVHLAAFLFMGPLAGYLCNRIGSRKLAILGGMMTFTSFLVTSYAKTLLHIILSFGVLGGVGCGFVFVSAVTIITKYFKKRYATAHSISNSGSGLTIVVLPLLARFLIDLYSWDGAMFILAAASANMCVCGMLFRPLGPSGRELSDEERPRLCKETGALSLQDEVLNGGLRGSRGNVYRKISSTSDGQPGGSEKTDLKVKENPDGKPHRKVATSSGTESGSEGVVKTNNGFSEGKPQKKVSICPDYIAETEGAVNLKGVSDGQLQRSLSESYGCSSDVQEGELPRLSEVSVSGAQLNGVSVNLSARMEQRRPTMASIYLGHIARGSGLFLLKTRFRFSFLCLLQAVQNIAFSSVTIHFVPMTIEAGISKLDAAVLMSISGVGSLFGRLALGQLIDCKVVGSLKIYFFAVLTCGVAMVVCPSLQTFAGYLVFALVFGFMSGTYKSLSAVLIREFVGADLMPLALGIFMPFIGIGIVTGPTLAGWLYDIRENYDLAFYITGSILVLSSSLLLLMPYLKRLEDRRRHDSETNDALEEELAAGALRIGSVQSLDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGG3</accession>
    <name>A0A913ZGG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050868.1">
        <property type="nucleotide sequence ID" value="XM_038194940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194940.1">
        <property type="protein sequence ID" value="XP_038050868.1"/>
        <property type="gene ID" value="LOC119724019"/>
    </dbReference>
    <dbReference type="GeneID" id="119724019"/>
    <dbReference type="OrthoDB" id="6139456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="52152" checksum="507EB41B46677CB8" modified="2023-02-22" version="1">MDPIQPLQNLLGPFFELHNLVIGSVHAVKEAYQALKEGYQKSQAFVMKLFGPKAHERFPRKFREPGSGACASGGFYPTDSAGHYENQGVDLEILPGAKLVAPYSGVLYKSAGKPNQVTLQAGGGAFRDIKIIIDNVEPNRTISKTEGVHVIAGTVIGTVGFSATCRPSNYIHLSMKKSKPNRLASLLDGVLDDDVSAADLAAKDGYVDPGNYLGKRLLKTPKWTQVCDDFKIVWLGMVVKEGTVLGNNKDGETKDTSPEREPPPDTTTDRPDPTKLPPKRTPSFGLVMSPDNTQQTREALGFPEPKLASGSPFKNFTLRNLKIGSILAFARKLGLEETADALLTLVKTIVKLVGDKPCVLPESLSNDMLRIELQQRGLSSQGDRQTLLKRYRQPEDRCLLLQVSLPKNVYCKIDKSCLGVECCMNVKLFMVSFAFKAFMRFDPCEFQFVLGVNSWNYTMHILDSEFDYTFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGH6</accession>
    <name>A0A913ZGH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_038050529.1">
        <property type="nucleotide sequence ID" value="XM_038194601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194601.1">
        <property type="protein sequence ID" value="XP_038050529.1"/>
        <property type="gene ID" value="LOC119723753"/>
    </dbReference>
    <dbReference type="GeneID" id="119723753"/>
    <dbReference type="OMA" id="PTINDCI"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="596" mass="67182" checksum="FAAE5FDD700AC131" modified="2023-02-22" version="1">MYRGHTYIYFGLPLYQVLPMPVDTRTRLQYSNKVYNPLKTLTRRVLLPVYGAFFISLEFEKVMEITSKTVAIIGCGVSGLAAVKCCLDEGLQPTCIERADDIGGLWYYRDNSEHQAMTTVYKSTITTGNKEGMCYSDFPFPKEWPNSLRHSYVKKYCDMYADKFGLNEHIRFSTRVTRLAQAPDYETTGRWVVTTQPEGSAGSEETSQEFDAVMICTGMFNNPHIPDFPGLDVFQGKVIHSQAYRTPDEYKDKRVVVVGIGNSGGDAATDVSRLASQVYLSCRRGVWLTGRRGDNGYPFDLEVIRRYYWIPLKLKMMLLKKSIERRNKFAMASLQPSHDLLACEPQMSEQLPDCIMNGSVVIRAGPARFIKTGLEFEDGTFEDDIDAVIMASGYRFKIPFEVDCPALEMKDGSVPLYKLVFPLGLKHNTLSFSGAMEVLGAVIPCVELQARWAARVFKGLAKLPSQLEMQAEVTMTDELMKKSFLPPHRHVGAVAYGDSIATEIGARPNFLKLFFTHPVLTLRCLFGPHVPYVYRLTGPGKTEEAKKAINTVWERVLAPTVTRRVEVKRESSPLAFQFLCLSIVASVTAILFVQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGS9</accession>
    <name>A0A913ZGS9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 164</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050225.1">
        <property type="nucleotide sequence ID" value="XM_038194297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194297.1">
        <property type="protein sequence ID" value="XP_038050225.1"/>
        <property type="gene ID" value="LOC119723575"/>
    </dbReference>
    <dbReference type="GeneID" id="119723575"/>
    <dbReference type="OMA" id="FIYIMHG"/>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36160" checksum="E29A8EEEE2C3F721" modified="2023-02-22" version="1">MSVRDFFLQIPSRYRRNLLVYNALFTMATLVSYIQPSEWQFQWVCHGVDEQVPGSGGQECALFLGPIQRLLETILVLSVCAIEMWLTWPRLEIPASLLEAVERHRLSGRGEAGKRLLLIVLCVVFGVELGLKCASKSVIYMMNPCHVLTLVQIYLLAVPPSRTALIVFRAHMSALSGPFLAIIFPVLNTRLLSCETELYWVQHMLIYLIIPPYLMSLGGAYTCEPLSNFSWVMFMTGAQFIYHFVPLQGVALLLHVNLNNMLCPALSDPFHSSWYRMFALVHQHMLLPVHLKLYTLVMRLILPVYAEPVNGDVIKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH37</accession>
    <name>A0A913ZH37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050366.1">
        <property type="nucleotide sequence ID" value="XM_038194438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194438.1">
        <property type="protein sequence ID" value="XP_038050366.1"/>
        <property type="gene ID" value="LOC119723658"/>
    </dbReference>
    <dbReference type="GeneID" id="119723658"/>
    <dbReference type="OMA" id="FNETRIV"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050659">
        <property type="term" value="F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019319">
        <property type="term" value="P:hexose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="500" mass="57241" checksum="F2578657C38A0689" modified="2023-02-22" version="1">MQLQKDFICVVILTCAIFGIKMLLDDLQISSTHGRRKDTLLNGDDPQQDFHRLDNVPKGEIPYGSDIRAELVEADERDNSSPELSTLIATRANTSKLRDKCPHQTGFQNVDDAKAVQAEPVLKNDSVPIKEDAKNDSIPIKEDAGGPRLRSSVKHNFRNLSKAFYRLAPDIFDGVPERFLHEFKNPCWRAPSPLAAGGRRVSAGAAATTTLRCMPYFFLAGMPKSGTTDLHAKLHGHPQVIQTTVKEPHWWTRHRFHGVSLQRYLERQSINIASRLVHGADPNIVIGDSSASTFWDNTQWHKFSEDISPPNILSEIIRTILPATRIIVIFRDPVDRLYSDFNYFNHHNYDKGPSIFHDLVVKFIAEFQSCLGKKATDYRDCTYLLQNKTQTRMSLGMYSVYLRDWLKVFPRDQIRVLRLEDWHANCTSILPELYNFLQLKTLDTAKISEICDRRSSNVNRAPTKSMRPDTRQILTDFYRPSKVDLAELLGDDKYLWIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL49</accession>
    <name>A0A913ZL49_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052522.1">
        <property type="nucleotide sequence ID" value="XM_038196594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL49"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196594.1">
        <property type="protein sequence ID" value="XP_038052522.1"/>
        <property type="gene ID" value="LOC119725254"/>
    </dbReference>
    <dbReference type="GeneID" id="119725254"/>
    <dbReference type="OMA" id="YFFIAIC"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="483" mass="50917" checksum="9317A33CFEF9A8BB" modified="2023-02-22" version="1">MELQTHENGNMEGSQKDANSQVPSPMETPPRGLATPEEAVDADGDQQPAKSRFTSHQIATIVGTLLAALTNMMAFSVITVFYPIEAKKRGISQTVIGMVFSVFSLSYGIGSPLIGKMIPIVGARFVFLAGSFFTGGCNILFGFIIDMPTNATFTGFSFAIRILEGLGSAAALTASAAIVASVFPDDVGKAVSLVETTIGFSLAIGPAVGGLLYNAAGFRTPFFILGGLVLSTVVVNYFLMPNEGNEAEESGSVSRVLSIPAVWVALFANFVGFAATASLQPTLAIFLDELNFSVMAISLLFVSLGLGYGLFSVIWGAIADAKKCARILIVVGASGSGGLFLLLGLPQILHLPVTGVLPSVTIPISAATFTMLATPTFVDMLRSAEWYDIPSGIGLTAVISGLWHSSYALGSLAGPLLGGVITEYYGFGYSIMTIACTSFTVLIITCLFGIWEFRCGKGRREPREAFSSEDNSNDQEMRLLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLV1</accession>
    <name>A0A913ZLV1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052778.1">
        <property type="nucleotide sequence ID" value="XM_038196850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLV1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196850.1">
        <property type="protein sequence ID" value="XP_038052778.1"/>
        <property type="gene ID" value="LOC119725443"/>
    </dbReference>
    <dbReference type="GeneID" id="119725443"/>
    <dbReference type="OMA" id="LEYECTA"/>
    <dbReference type="OrthoDB" id="5987060at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="542" mass="59600" checksum="47860505DF51E119" modified="2023-02-22" version="1">MEAKAFCQRLNYHGRNGSLATVTSPDDILIISKFADDMFKYATGFDVPSFIWLDTHAMNTTAKAFCQRLNYHGRNGSLATVTSPDDILFISKFADDMFKYATGFDVPSFIWLDTHAMNTTVSDLEPILDLPFGQTSDVTPCENNQVVDSEVYQVVGTAQMVPGPGLVEQPCAVHAPLGSFLDLGDFAGSCVSDPGLCESESVTWSIWLKIDTPVSVNKDSWYYLSSGGQTGQARGIAFAYKEDTNTQRFLFTAKSEQFRVHRRYDKSKIPLDEWFHLAFTADLSDTRGTDLQLFVNGETVNADVTENQSITQSDGCTHLYIGMSNTCAGTYSVDTYGGSAAYSNLVVFDGLLGSQQIANLYKCGSIDWRPRIINFTMTHYGITDSAIRFNCTADGDVITWSLLHESNHNNMSSEHLEAAAGAGYTIQAVNASRCVIHSTLEIDLSHGLPLEGALVACTAHSYRLRDKVSMFIYQGKQVNIGTSDHGSIGLSLREVGNHEAQFIIQDGDYSEMYCDSAYPTTASNIGESCSEDQQNHPFICQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM92</accession>
    <name>A0A913ZM92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052464.1">
        <property type="nucleotide sequence ID" value="XM_038196536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196536.1">
        <property type="protein sequence ID" value="XP_038052464.1"/>
        <property type="gene ID" value="LOC119725175"/>
    </dbReference>
    <dbReference type="GeneID" id="119725175"/>
    <dbReference type="OMA" id="NCCADIL"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687065" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="670"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="107380" checksum="364FBB3FC5203C46" modified="2023-02-22" version="1">MEAGLQQLSLLLVTCLCCADAQGTTDFMSGIPSTTDPNTDITLPKTTDGPTTPAAKEIPYACPSRRNTWHTCFFGCLEPPWKQFYCHCDDLCLTYDDCCPDYEEYCGVGTFGVDEMTTVGVGVIDGDRRSGIENTAEYMRCIQTDEFDPEGSRPRSGFWLVAVCPQDWTGAAAVTELCEETIGIDGLAAVPVEGFDRRHYRNVYCAMCHGLPHTDVTFWTICYKDNSGETARPIPNSLFLQIARGQVPSDGYQKFFNPPNVDDAEYLAPSMLRTCSILDAISCPISDPRALELCQRHYAPITWNGTTYRNFACVRCDDTPIPPSDILSTWCTFSRSGEKGGSMATLLVFSDHTDIGGSLTQAESVGSNTACTHRQIYDPFSSSCLDLSCPEGFALRDGGVGCARIRETENESTGLKSNVEVALTVTVSLDMDTEAQHTNGLSEIWEEVAHQAAKDYQSTTSLCEFDEEMTENNQVDRDDEICDDFSVQWSCTMDVAILDSTPACLSGSVFKCSINVSFDSLSPSVDHFIAQSDELSSKCFVSRVWNHTIRPDYLAVSTPCDNLSNDTGEDSNFNIVFTSKVAYVRDKDSGHFVVSQNDSCMELFVDCPLLTFSKEDYVITGALNDSIRLTAHDRVFRSGEFEIKSDGDVEVCNFLPPSADPPYMTFGPAQDILTATGSSLSLIGLVVTIATYVAFPSLRRNAAGRALMSLVAALFIAQLTMLIGLDRTDVPTLCVTFAISSHYFWLAAFFWMNILAVDIYRTFGIGTSLSDPNERSFLRYALYGWGAPTLIVATVAILSFCDCVDADVSYGTARACWVGNGTANLLSFGLPIVLILCSNAVLFSLTVAGVRRTRMTSKRMNICQGQSGLAAERSNNDLLLYLKLTAIMGFTWVFGFVASFSGVEFFWYLYIVLNSTQGALVCLAFVCNRRVLAMWRAWLDSRRGRSDASASGRGQRSFKSAVTEQRQAESAIKDTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNX6</accession>
    <name>A0A913ZNX6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053442.1">
        <property type="nucleotide sequence ID" value="XM_038197514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197514.1">
        <property type="protein sequence ID" value="XP_038053442.1"/>
        <property type="gene ID" value="LOC119725905"/>
    </dbReference>
    <dbReference type="GeneID" id="119725905"/>
    <dbReference type="OMA" id="TECFFRI"/>
    <dbReference type="OrthoDB" id="5950113at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037296888" evidence="1">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="299" mass="33155" checksum="595B29C8028D5665" modified="2023-02-22" version="1">MKTACVLVLLLPAILVQGCVPEGNKWDIFLTEDTFSADDSCKAEERCRECGMQVCTLPQMKLAFEFEYRNLAFGLYRGSESDNRKARVSSCDYDFPSQECFYEGREILTVPLSDGEEVAAYCCPSTGPSLTVSKFHSHAEAKESCPGTGARLCPLVLLAYANNLGYATAEWGWYASPNLFANVEEDELVVCYDPQAGQTARAGYCCPMVNSFVLSEDEYATHGEAQAFCASMRLHLCSLAELKSARDHGFWGPSWGRYEVEGRDVKVSDCKYWSGPECYEGVIANTPRPRHTLPAYCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ32</accession>
    <name>A0A913ZQ32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053817.1">
        <property type="nucleotide sequence ID" value="XM_038197889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197889.1">
        <property type="protein sequence ID" value="XP_038053817.1"/>
        <property type="gene ID" value="LOC119726261"/>
    </dbReference>
    <dbReference type="GeneID" id="119726261"/>
    <dbReference type="CTD" id="6923"/>
    <dbReference type="OMA" id="GQEQMDQ"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13643" checksum="5AADB0C639D7EDD5" modified="2023-02-22" version="1">MDVFLMIRRKNWTIFTDAKETSTVYELKRIIEGIIKRSPEDQKLFKDKEELDNTKTLADCGLTSNTAKAQAPAMLGLACKLDGDTDEFETLDLQAYSNPPELPDVMKSSEPSTTNTVEPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQV6</accession>
    <name>A0A913ZQV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053520.1">
        <property type="nucleotide sequence ID" value="XM_038197592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197592.1">
        <property type="protein sequence ID" value="XP_038053520.1"/>
        <property type="gene ID" value="LOC119725966"/>
    </dbReference>
    <dbReference type="GeneID" id="119725966"/>
    <dbReference type="OMA" id="MTEMDIL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="6">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36720" checksum="21CA4199D0E79BF6" modified="2023-02-22" version="1">MSSPTCEDEGLPSWAQSWHIPFRNMMIGDMVLGKGNFGEVRYGAVKVEGEDFKAAIKTLKAYESKNDRQNFMDEFRILTKIGRHPNVVSILGACQHDDILYVALEFMPNGDLRTHLRNARSQDDDGQSSLSSYAKLIQFAFDVAKGMQHLAALRVIHRDLAARNILLDNQLVAKVSDFGLSRGEDIYVQTSQTRVPTRWLSPESLTYNAYTSKSDVWSFGILLWEIATLGATPYENITTKDLMSRLEIGYRMAKPSNCDDEIYNLMLMCWQVDPAKRPSFNQLVTRLTSMADNPNEQTYMRMLPKTEEYMHMMIRPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRD7</accession>
    <name>A0A913ZRD7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053715.1">
        <property type="nucleotide sequence ID" value="XM_038197787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197787.1">
        <property type="protein sequence ID" value="XP_038053715.1"/>
        <property type="gene ID" value="LOC119726179"/>
    </dbReference>
    <dbReference type="GeneID" id="119726179"/>
    <dbReference type="OMA" id="SECINMS"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="512" mass="58544" checksum="6975526EEC2B2410" modified="2023-02-22" version="1">MCFICRLKVHPIAPSPTVKMASNVTVQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLQELRQSQDPSGTKLTCPLCRRETMLKGSGVADLPNNFAFSALVEEVTMQEKLLKGQGSEIKCQACDEENQAISRCIDCDHFLCQECQKAHKRMTVMKSHKIYTLAQLRSGEIVYKSKLREEVPKCGKHPDQNLNVYCNTCEQVICLMCTVLDHEKPKHSFIGLPEAFEKCKKKVEELVANIGKSKTKLNKTIDKTCQSRKKLNKMFANIKKKISEKAEREVAKIRQEEQKLLEETDRIYQERITPFEAAEATNRKEVTQTEHKLEEVKQLMNQASCYEILGLQQKLLHNLSELTGKQPQQVPDKLTFMNFEEGERSLGRLILEEEPKAAAKQSPRRRRSFVKEKWELETKIEYVELTNAFITHVAALSDNKILALSRRFNGNSDALFEVSIPYSHKKGSPIPQKLHNYCLTDVRCIAVSKDDKLLVLDGPVVKVCNKQHQLLHQFTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTN4</accession>
    <name>A0A913ZTN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054804.1">
        <property type="nucleotide sequence ID" value="XM_038198876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198876.1">
        <property type="protein sequence ID" value="XP_038054804.1"/>
        <property type="gene ID" value="LOC119727003"/>
    </dbReference>
    <dbReference type="GeneID" id="119727003"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57125" checksum="E2A093F0D198F4BA" modified="2023-02-22" version="1">MDLLDLRTFLLGVLLLLVLRWLLGRPKNLPPGPWGFPLLGSIPAIVWGMFRGSEPHHQFHRYAAKYGPIFCFKILNKTVVVLNDYTLVKEAFQHPQLSDRPKNILTDVLKVDAVVVSNGEPWVEMRRFCLTVLRSFGVGKTSFEEKIGTEAEELMKEMAAFGGKPFNPKSFIGNAVANVICCVIFGKRYEYNDEEFKYLLDLLTQNAQLSGGGGLIGFLPGLRFLPLSPFPALLANFTEIFGFIGKFIDAHRKNFDADDLKDLTDVYLKEIQQNLARDKDGMLPDRKHVKNSKYRHLSERNIVGTIVGLFGAGSETTATTLQWALLYMMVYPDIQKRVQAEIDDVVGRNRMPRMADIPELHFTRAVTWEVQRLANIVPLGVPHSAASDIYLQGYLIPKDTLVLPNMWTIFQDPKHWPEPEQFKPERFLNGGGEAVKANELIPFSTGRRSCIGEHLAKMEIFLFFAFFMHQFTFKKPEDSPPLTLKGRGGLTHAPLPYELCAVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTV8</accession>
    <name>A0A913ZTV8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054645.1">
        <property type="nucleotide sequence ID" value="XM_038198717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198717.1">
        <property type="protein sequence ID" value="XP_038054645.1"/>
        <property type="gene ID" value="LOC119726864"/>
    </dbReference>
    <dbReference type="GeneID" id="119726864"/>
    <dbReference type="OMA" id="TICMEPF"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="45801" checksum="46482AF18AD50A01" modified="2023-02-22" version="1">MASNVTVQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLQELRQSQDPSGTKLTCPLCRCETTLKGSGVADLPNNFAFSALVEEVTMQEKLLEGQGSDIKCQACDEENQAISRCMDCDHFLCQECQKAHKRMTAMKSHKIYTLAQLQSGKIVYKSKLRDEVPKCCKHPDQNLNVYCNSCEQVICTTCSVLDHAKHSLTGLPEAAEKCKKKITEMVQKGESRKTEMSTTIEETSKSRKELDTMFANAQKKVSKKIQLGIPKIQKEEQKLKQEMDWIYQHRVRTFEAAQATNRKEVTQTKHKLEEVKQLMNQASCYKILELQQKLLHNLSELTRTQPQQVPEKLTFMDFEEDYYGASVFSVDMTSNMQGDGQPTGVCCDSDGSIFVAVCRCLTATDIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVN2</accession>
    <name>A0A913ZVN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038055559.1">
        <property type="nucleotide sequence ID" value="XM_038199631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199631.1">
        <property type="protein sequence ID" value="XP_038055559.1"/>
        <property type="gene ID" value="LOC119727647"/>
    </dbReference>
    <dbReference type="GeneID" id="119727647"/>
    <dbReference type="OMA" id="QTCNQMV"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043535">
        <property type="term" value="P:regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586442" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="24"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="505" mass="56185" checksum="A92971D8970C3475" modified="2023-02-22" version="1">MRTFHRTLLAVCAVLAALCTVSCTEQFHSRRIRRPVGLGLGLRAKSTAGMQCPDNKCRIYETYYIEQKIDHYGFINDDTFKMRYLVAQQYWDKNGGPIFFYTGNEGDITWFCDNTGFMWDIAPEFKAMLVFAEHRYYGESLPYGKESYMDREHLGYLTSEQALADYAVLIKYIKSSIPGAASSPVVAFGGSYGGMLAAWMRMKYPDAVVGSIAASAPIWSLNNLTNCNTQFTIITKDFTEVSPTCSKTIRASWAVIDKFGLTAEGKEQLRTSLRLCSPVLTGDDVAVIKDWLTETWFNLAMVDYPYNASFLEPLPAFPIEVVCSHIKSANATGVALLEELAEAVNVYYNYTGSAKCFNTSQTATGSLGDKGWGFQACTEMVMPSCMDGKQDMFEPSPWVYEAYVKECQADWNVTPRPDWPIVQYWGKNISAASNIVFSNGLLDPWSAGGVLKSISDTVVAVIIPEGAHHLDLRSHNKDDPPSVIAARNTEKANIKKWIAKAHGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWM2</accession>
    <name>A0A913ZWM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038055705.1">
        <property type="nucleotide sequence ID" value="XM_038199777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199777.1">
        <property type="protein sequence ID" value="XP_038055705.1"/>
        <property type="gene ID" value="LOC119727740"/>
    </dbReference>
    <dbReference type="GeneID" id="119727740"/>
    <dbReference type="CTD" id="8473"/>
    <dbReference type="OMA" id="MNESEHF"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="14">
        <location>
            <begin position="468"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116676" checksum="E19E0BCF2A02ED08" modified="2023-02-22" version="1">MFDKMGEPTSSTGTGLAELAHREYQAGDYDNAERHCMQLWAQEPDNTGVLLLLSSIHFQCRKLDRSAHFSTLAIKQNPMLAEAYSNLGNVFKERGQLPEALENYRHAVRLKPDFIDGYINLAAALVAAGDMEGAVTAYIQALQYNPDLYCVRSDLGNLLKALHRLDEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVGAYLRALQLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEQSKVSEAEECYNTALQLCPTHADSLNNLANIKREQALTEESIKLYCKALEVYPEFAAAHSNLASVLQQQGKLQEALVHYKEAIRIAPTFADAYSNMGNTLKEMQDIQGALQCYTRAIQINPAFADAHSNLASIHKDSGSIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWSDYEQRMKQLVTIVADQLDKNRLPSVHPHHSMLYPLSPEFRKGIASRHGNLCLEKINVLHKGTYQYPKELSPNGKLRVGYVSSDFGNHPTSHLMQSVPGKHSDKVEVFCYALSADDGTNFRAKVYKEAGTFVDLSQIACNGKAADRINADGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGASFMDYLITDMVTSPMDLGQHYSEKLGYMPHTFFIGDHWNMFPHLLDKIIVESKDGLKRDNVGIINTTDVKGFMEKVNSVVPAKQPTTTAANGTASSKKTENGNGDKLAHSANPLQFAVMDNSISQALNTMVIQGHAQASINGMNITHGLAVNQVQPKAATGEEVPTTPIITTRSMYSIPDDAIVYCNFNQLYKIDPATLQMWVSIIKKVPNSILWLLRFPATGEPHLTASATRLGMPAGRLIFSPVASKEEHVRRGQIADVCLDTPLCNGHTTGMDVLWAGTPMVTLPGETLASRVAASQLHCLGCPELVASSRQEYENIASRLGTDPDFRNTMKFKVWKGRTESPLFNVKTYTLSLERLFFQMWEKQEKGEKADHVNWTPENGASIVEISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWQ6</accession>
    <name>A0A913ZWQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056083.1">
        <property type="nucleotide sequence ID" value="XM_038200155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200155.1">
        <property type="protein sequence ID" value="XP_038056083.1"/>
        <property type="gene ID" value="LOC119728081"/>
    </dbReference>
    <dbReference type="GeneID" id="119728081"/>
    <dbReference type="OMA" id="WVENTIY"/>
    <dbReference type="OrthoDB" id="6151979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037294873" description="WSC domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="13">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45666" checksum="C3A0F218EF689648" modified="2023-02-22" version="1">MGEGLMIRQRLGRALLLWLMTFQLAFLPSKQQNSPGYLGCFLDVNGDRALSVGPAEEYMSVEWCFRHCLEPTAYKYAGLQYAHECWCGDNEDYDRHGEQSDCRDKCTGNSDQICGDSWRISVYRVSQGVCSNDIGPPTNGHHDITNPRSLSYNLNNFKFFGTRVDFSCDPGYNLHGASKIECIETGYNNVTWSDSVPTCEVPSIQTTLQSKVTDSLMTIGNSKTDEMPSSTDFISETPANNNPNTGVLQKGAIVGIAVGAGILTVLILLVILLCKKRRKPKKKRPDVTVATIGDRYTNNAYALPEIVNQSITDQSTMPVYSRVIKDRTDSDDVYATPDDITSPGGDGNAPSDQAKGVTASRDQENGWVENTLYACESFPAEPAPARVKYSDGQTNSGPPLKMEGKPGWVENNIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYU3</accession>
    <name>A0A913ZYU3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056808.1">
        <property type="nucleotide sequence ID" value="XM_038200880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200880.1">
        <property type="protein sequence ID" value="XP_038056808.1"/>
        <property type="gene ID" value="LOC119728585"/>
    </dbReference>
    <dbReference type="GeneID" id="119728585"/>
    <dbReference type="OMA" id="LMCVICA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="640" mass="71853" checksum="43EE903A8FAED97F" modified="2023-02-22" version="1">MAEAAAKTVLDKISQGHLECPICCCLFKDPKMLDCLHSFCLKCLEEMMSKQKPDTEKITCPVCRKETQVPDGGLHSLSSSFFLSSLVDEVKQQEAVLGEASIPTATCDCGKGKEATWRCLDCSDNFCQECWKVHGRFKYTKDHQIISLGYWQESKMPPAEHSKPITRMCTIHTDHPLCFYCDTCDTLICSMCVALDHRSAEHNFLKIDDLIRSFRSEVDNILQKFEKSRQHFKSTEKSIEHARNRLQKKLAQAHSDIDAKAEAEITKIRNKAKLLTDKVNEIGQERDSEYEKVLTNNREQMERADHTIAAVNDLMSQADDLELLELKPKVMHNLEFQKELKCELTNHGPSFICVRCHDVVSDAELGEVCVSEKWQLKEEFGKEGTGDGEFDWARAVACFTNRDIVVTDRGLERLSLFSSTGRYKTSVAKGDARHQLEAPFGVAVTHDDLLFVTDKKKVKVFDNELHFVREFTPSVDDADGRSKSNLRAVAVDSQRVAVADKGRKVISVHNLDGSLIASISNNMADQDLAISNFGCLVFTNYEGQSLLCVNFKGKEMFSVKTFVNGEAAKPTGVLCDDDETIYVVVHYRARGSCEVQRYNSNGAFVATVAEGLYNPLGMAFTPAGDIVVADRHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0N0</accession>
    <name>A0A914A0N0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057145.1">
        <property type="nucleotide sequence ID" value="XM_038201217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0N0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201217.1">
        <property type="protein sequence ID" value="XP_038057145.1"/>
        <property type="gene ID" value="LOC119728820"/>
    </dbReference>
    <dbReference type="GeneID" id="119728820"/>
    <dbReference type="OMA" id="FITIPEC"/>
    <dbReference type="OrthoDB" id="5950702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="178"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="382" mass="42334" checksum="17B24B80E15D3D8D" modified="2023-02-22" version="1">MPRPKRTAPPPSRLADIDTDHAHDGVQPSKRRRGAKSSTRSSGQESSQDRTVPSDASRGSEHDDSFTHPPSNLVGQEMARLLSAAFSPHTHRAYASGWSAFCRFRKNIRTNLPASVAETREFIAWLSLQGLAHATITTYVSGVGYYHKIRGWPDPTKDFIVSKLMHGCRRDRNRVDERLPMSLPLLAQIIEAFTHVCSSHYEATLFKAAVTCAFFGFMRLGEFAAISKTKLQESLLHISDIEFCDLASTQQSVVISFPYSKNNKTGAPQRVKLVTTQNSALCPVMALQGYISIRPSGHGPLFCHFDGSPLTAYQFNAVLKKALTFCGKGDLHYRPHSFRIGAATTAYELGVPSTDIQQMGRWRSDAVLTYIRPMPVVTIPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1Z3</accession>
    <name>A0A914A1Z3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 65</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057852.1">
        <property type="nucleotide sequence ID" value="XM_038201924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1Z3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201924.1">
        <property type="protein sequence ID" value="XP_038057852.1"/>
        <property type="gene ID" value="LOC119729302"/>
    </dbReference>
    <dbReference type="GeneID" id="119729302"/>
    <dbReference type="CTD" id="157378"/>
    <dbReference type="OMA" id="CCWMGTH"/>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28339" checksum="DEB907E92322572D" modified="2023-02-22" version="1">MAASMRKIGFRRFLQILDKDLRFSVKNSTTWVAPRKNCDYSRDVPILGVFGCWNIQTRHQYTYRGRLFRGKLDTESKCKHFAASLFPNERALVLAELQGLQDHIHRTDKCATEPPSKAQLRLVLLSNGIPFIGFGFLDNAIMIVAGDYIDLTIGVTLGISTMAAAALGNLVSDLAGVGLAGYVESLASRVGVHPKELTPEQADMRKTRWIAGIGRALGLTIGCLLGMFPLLFLGTREEVEESPTEGAAAVTGDQSKIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3D0</accession>
    <name>A0A914A3D0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058099.1">
        <property type="nucleotide sequence ID" value="XM_038202171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3D0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202171.1">
        <property type="protein sequence ID" value="XP_038058099.1"/>
        <property type="gene ID" value="LOC119729561"/>
    </dbReference>
    <dbReference type="GeneID" id="119729561"/>
    <dbReference type="OMA" id="FKKQWHR"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF81">
        <property type="entry name" value="METAL TRANSPORTER NRAMP1 HOMOLOG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="614" mass="67678" checksum="AC66D0AE2A023951" modified="2023-02-22" version="1">MEMYTRGAEKVAWQHRSRARRGAGILDVQRVLRSGGPRVEVAGVGPASVMGSPEEAKPLLSDESQATCYFHSSDASSANGDGVHPCTMDIALQGNDEDTSNPGTIDIPETEGTKFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAIAEYKLLWVLWWSTVLGLVLQLLAARLGNATGRHMAEICYQEYPTFPRVLLWIMMEIAIIGSDIQEVIGSAIAINLLSNNLIPIWAGCLITGVDTFTFLLLENAGLRKLEAFFGVLLMTMGISFLYMYITVKPDQVAILEGIAIPWCSNCSSAAIQQAVGIVGAVIMPHNIYLHSALVLSRKVLHKRKDKVREANKYYSIESAIALFMSFLINLFVVAVFASAFYGKPNPSLKAAGGWIQDRYGEVLKIIWGVGLLAAGQSSTMTGTYAGQFVMEGFLKIRWPKWRRVLLTRSIAIVPTIFVSVFAVGTLDVLDNLLNVLQSIQLPFALIPVLHFTSSTRIMGDFKNGRITKFVVWCLGISVMGINFYLVYQEIEDTPAWVYVVVSLVGAVYAFFVGYLAIGTKNVYRIKYRLLSWLKRTPEVSVGEWTSSRPIYAQTLAVEGCCEATVETYTPITQPSAPPLYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6M4</accession>
    <name>A0A914A6M4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH2B adapter protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH2B adapter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059405.1">
        <property type="nucleotide sequence ID" value="XM_038203477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6M4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203477.1">
        <property type="protein sequence ID" value="XP_038059405.1"/>
        <property type="gene ID" value="LOC119730511"/>
    </dbReference>
    <dbReference type="GeneID" id="119730511"/>
    <dbReference type="OMA" id="YCMRSTQ"/>
    <dbReference type="OrthoDB" id="10047184at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01231">
        <property type="entry name" value="PH_SH2B_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015012">
        <property type="entry name" value="Phe_ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036290">
        <property type="entry name" value="Phe_ZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030523">
        <property type="entry name" value="SH2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872:SF2">
        <property type="entry name" value="LNK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872">
        <property type="entry name" value="SH2B ADAPTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08916">
        <property type="entry name" value="Phe_ZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109805">
        <property type="entry name" value="Phenylalanine zipper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="211"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="462"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="71308" checksum="3BABE8C8C56772BC" modified="2023-02-22" version="1">MNGMESHDNDRVTDINEFCEVEAQKAAATFALAYHQFITENPPADDIPVDENRFARRFADHFMDHFETEVRRAYNTVSPSDLREDQQNANTHDDPAGSPAASPTESENNANVNTRLLSSDSGPRPGNRNGTTAMFNGDPNGRYSSNSSLDGNHINSVNQTPPPRSEVKLPRKFSFRNMTENVTHVINRFRKAHQTTGQHHRERGIRYAPEDIVREGIVNLLTGEDHQCKQKWERSRLVLVKRLEGHMLDFYAPPKSNKPRNGIFCFLIEEARETTALELPEKENTFVLKAENNLEYVLEAQSMQDMRSWLTNITACMNMPNLPRRPLPSVPDHSPEPDNSSSSFSFLRARPNLTVQIPDWTANSPSNSRSPLTPENSGEGFSSRDPSPPASPPPRIPPRRRHGNTNSPDRLPSGGSDTPLSPDLPPLHDAQSRILDGSNQNINLDSEEPAPVTDHPLNEHLWFHGTLSRVDAAKLVLQGGNASHGMFLVRQSETRRGECVLTFNFHGRPKHLRLTLDGSGRCQVTHMWFESIIDMLDYFRSNPIPLDSRDGASQPDVTLTEYVPNAQSVSTPSTPLTPQTPEAGGNGRGLGNSNSLMVSSNEFLGSGSQFSLSMNSGGQSPSPLDGQGRGSSTRAVKNQYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9J0</accession>
    <name>A0A914A9J0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060520.1">
        <property type="nucleotide sequence ID" value="XM_038204592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9J0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204592.1">
        <property type="protein sequence ID" value="XP_038060520.1"/>
        <property type="gene ID" value="LOC119731422"/>
    </dbReference>
    <dbReference type="GeneID" id="119731422"/>
    <dbReference type="OrthoDB" id="10666410at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="26722" checksum="5F0E7D04CCC9F621" modified="2023-02-22" version="1">MQIASYCFVTVIAVERLSAVRQPLTQRARAIKSRAAKVSAGVWVVAVVMSVLGGLANDTNYVTNVVFSQVYVVTFLLIYLATFTITVSSYIFIIIKLCHSDRKRQAGQTRRAYPVVRMLVINTAVFFVLSLTDFTFTVISLILLFSLHSGAEAVFDIYWTILDVEVCLGIFRLINSSINTLVYSVTNSQYRAAFLEAFPPLAKLLEQCRRCRRSQQTEQIELRAIPLAIAAQESPAQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9X4</accession>
    <name>A0A914A9X4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-2-macroglobulin receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060209.1">
        <property type="nucleotide sequence ID" value="XM_038204281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9X4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204281.1">
        <property type="protein sequence ID" value="XP_038060209.1"/>
        <property type="gene ID" value="LOC119731203"/>
    </dbReference>
    <dbReference type="GeneID" id="119731203"/>
    <dbReference type="CTD" id="4043"/>
    <dbReference type="OMA" id="QEFEHHQ"/>
    <dbReference type="OrthoDB" id="5817428at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048259">
        <property type="term" value="P:regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.10">
        <property type="entry name" value="RAP domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038003">
        <property type="entry name" value="A2-macroglobuin_RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010483">
        <property type="entry name" value="Alpha_2_MRAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009066">
        <property type="entry name" value="MG_RAP_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036744">
        <property type="entry name" value="RAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560:SF2">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06401">
        <property type="entry name" value="Alpha-2-MRAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06400">
        <property type="entry name" value="Alpha-2-MRAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47045">
        <property type="entry name" value="RAP domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036766476" description="Alpha-2-macroglobulin receptor-associated protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin receptor-associated protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin RAP C-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="40623" checksum="AA718713F07CD86C" modified="2023-02-22" version="1">MNSCGVALVVLCACASLWSVAQAQSKYTENVNIKDNQVDRFRTKIVQQVWEKANRMNLPPKKLEELSQTLQQHDVKVLQLKKHQQDGGDPEGDTETLLRRKLTDIMRKFGIIPYDGKEQLRMKEANQKRDMTGEEFQDHKLNKLWIKAQQSPNFNKLELEQLKEELTHHQEKKEQFEQLSGQLYGDRTRDANRVETHADKKRIDPDERSVLELDLKIQHRELTNDFQRLSNKMLPDEHKGEFTEPRVINLWREAMFANFTAEELESIRAELKHFEAKIIKYEDVQVQSLHAEKQYRIAKKQGDSVDSLKHKTLRDEARELGNNVHEFMNDMRGRIQRGRDRADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAW8</accession>
    <name>A0A914AAW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060519.1">
        <property type="nucleotide sequence ID" value="XM_038204591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204591.1">
        <property type="protein sequence ID" value="XP_038060519.1"/>
        <property type="gene ID" value="LOC119731418"/>
    </dbReference>
    <dbReference type="GeneID" id="119731418"/>
    <dbReference type="OMA" id="WESHPRW"/>
    <dbReference type="OrthoDB" id="10043879at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="71"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="50727" checksum="C75BB222FCA1D897" modified="2023-02-22" version="1">MVPRVKVLRLAHDNRTSGHLGITRTVARLRQAPVFWREMQRQAEEWCQKCHKCGSKKSPPRPLKAPLQQYLVGAPMERLAIDLTGRFPRTRTGNYSIMSVADYFTKWVEAFPIPDQTAQTVAKVLVEQVITRFGAPLEIHTDQGREFEAELFQGTCKLLGVQKTRTTPFYPQSDGMVERFNRTVKTMLSLFVHENQDDWDEHLPYVMMAYRSSQHDSTKFTPNMLMLRSAASVGPGESASYKPGQPVWMYTPSKKVGRTPKLQCWWDGPFVVTQKIDDVTFRVQESPLAKAKVVHSNRLKPYLGDAEVDWWRRVAQNLPKGGPPPTQDQEVTLPPSPSTDTNREDPPAGVGSQFAKEGPLPVKTGKGTLPEATAPAAQKRTGQRGRRIRYGIGRARRGTGLFTTIGAGSWESHPRWPEDNPTKPLLPTNNQMLFFFFPLQDGPGPDSLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AES2</accession>
    <name>A0A914AES2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062452.1">
        <property type="nucleotide sequence ID" value="XM_038206524.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062453.1">
        <property type="nucleotide sequence ID" value="XM_038206525.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062455.1">
        <property type="nucleotide sequence ID" value="XM_038206527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AES2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206524.1">
        <property type="protein sequence ID" value="XP_038062452.1"/>
        <property type="gene ID" value="LOC119732939"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206525.1">
        <property type="protein sequence ID" value="XP_038062453.1"/>
        <property type="gene ID" value="LOC119732939"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206527.1">
        <property type="protein sequence ID" value="XP_038062455.1"/>
        <property type="gene ID" value="LOC119732939"/>
    </dbReference>
    <dbReference type="GeneID" id="119732939"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="17982" checksum="6A7B83ED2EF185EC" modified="2023-02-22" version="1">MATEQPQAPPPAAISRDRRLLIPISNERSRGQRKTPVSFVVVPVSDLGYPVGSPGSSIWAYTPGSSGDWIPSSNLEDIPGTAANRMPYFPHQDTVKRGWLPNEQTPVSRFGEQHEPMSGMHHNMAMGDGGGVTAHGMAGTVWNPVATMQLHGTNPKVWGASRSQSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFK9</accession>
    <name>A0A914AFK9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038062522.1">
        <property type="nucleotide sequence ID" value="XM_038206594.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206594.1">
        <property type="protein sequence ID" value="XP_038062522.1"/>
        <property type="gene ID" value="LOC119733013"/>
    </dbReference>
    <dbReference type="GeneID" id="119733013"/>
    <dbReference type="OMA" id="IRRDTHR"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="916"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="107"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="21">
        <location>
            <begin position="221"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="405"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="499"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="609"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="711"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="808"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1045"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1351" mass="147701" checksum="12326FCDFD5CB80C" modified="2023-02-22" version="1">MVLFDSTEDFPSDAGISVLLEGEDHAFTCMVLDINHEVELVWTLAGRRIKQASNRSVDTIDGLSVSSSVVVSPNREIHGQTLQCKAFDTDGELIDSMTVTIAVKVKPKSSLMSLTGASGNRLRPGGTVNVATGIAYTFTCETKDTWPETKIEWYLGDIRRDTHRPTFTGSDDLVTTRDSWALTPTSESNGLELRCVASIEEPFDAQASLVVRVVVNSTVGLNCTFEEGWCGWKQSKQDRTDWTLQAGSTYPSSTGPDYDKTVGDYRGRYASFHPYYSSDGTNAVLISPAVVPSKEQIGNHAWCFSFWYNMYGSNMGTLNVSRVPVGGSVTGGEVLFSRSGEQTNGTTWLEAEICVTNLSSSFLIAFEAIRVNGRLSDIAIDDLTYQVAKTSIILFDWFGHNFSMGDTVYASGRDCTRFTCRVPDIRTPVSLMWTLGGLELSPDSSNNLTDSDGFTTSTSTVTIPISGSNHGELLQCMAFVAGIHPVVNIFVTVDVQVPPKESSLSLYDSGGNVTSGRASVMEGARHSLLCTVRQTRPAATIQWFLNDALQRTDDPASGEINGLVDTTSSWTFIPSRSNHGHRVKCVARTAESQLPLPFAMVTVDVTGPPDTPVIIGHPLMTANETVQLTCRASNGYPDDWELVWTNGGPTLAGTHTTAMSTSGNRYRFSSTLNFSPTREDNGNMITCSARRGPWTQDLTGLLGPIDVQYWPEFSEPSVIPSNHVEEGDDVILSCIVDANPKPADFITWEKVGSPGSLPSVYSNGTSTLLLSNISRERAGTYRCRGDNGVLPVAHSSLIHVIVRYKPHPPGAVSIHTEKLSSESLTVTWSPGSDGGEPQWFRVNHRELKTTTVFSRSTQSGRLYDVSEYTVVSLQPDTEYEIEVYAENANGASDVLTTFGKTLPPVAHSVIGTPTSWPFLTAISVLGILLLISIAIQTVGCYYRKRKKPSQKKRKTLDTGMLIFKTMETLSLFNLFKISTFSTEQQNVSQSSGAGTGGPVRVVEDAECYENVGIPLQTIRAVESDPVESTYADIPDCRAAISRDQLTFLQELTQGTFGKVLLARAVGIEQQGLVTRVAVKTVKDESDPKEKENLIRELNSMKPLSGHANIVKLLGYCINEDPIYVIMEHVVNGNLKEILTDSRSEHVYDNLRGAVCASLTPKTLLSLARGVAEGMAYLASQGCLHKDLAARNVLVSEDMVGKISDFGFASDVAEMRTYQRKSTGFSPLRWMALESVLDDVYTTESDVWSFGVLLWEIVTLGGHPYPTMSAKKVVSKVKSGYRMPRPDHCRMQLYQVMRACWSKNPAARPTFATVSEKLGGLLDKANECISLETCQKSVYKMSVTGGSDFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFW9</accession>
    <name>A0A914AFW9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062406.1">
        <property type="nucleotide sequence ID" value="XM_038206478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206478.1">
        <property type="protein sequence ID" value="XP_038062406.1"/>
        <property type="gene ID" value="LOC119732885"/>
    </dbReference>
    <dbReference type="GeneID" id="119732885"/>
    <dbReference type="OrthoDB" id="6267506at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="342" mass="37301" checksum="E2422FFB090E9203" modified="2023-02-22" version="1">MGLAAERFQFSLDTAREVTRTASDSDFLSLYPTISKDLKLLADQSMPRVDNRLAFLKFKQSEGVGGISLGEVVVESKWELCREFGKWGSGPRDFDVTWGIAARRPDEIAVTDVDNKRVMICSIDGNQKSTIPMQGHPRGIAATRSDNRLVVVEEGASHVKVFNSDNTLAYEFPTVPPSEVGKTTVDLRSVAVKNDGTIAVGDVARMVLTVHSPTDGVLLHTIPVKIKPHFLAFDSNDRAIISDYESKTVDIAGGNGTTKRTFKPTINGQPVRCCNGVCTDGSGIYVAMHIGDYKGHIHHYDPQGGFLKCIAQGLHLPLGITLTLDEQLAVADYSSVKIYHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHJ0</accession>
    <name>A0A914AHJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038063148.1">
        <property type="nucleotide sequence ID" value="XM_038207220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207220.1">
        <property type="protein sequence ID" value="XP_038063148.1"/>
        <property type="gene ID" value="LOC119733853"/>
    </dbReference>
    <dbReference type="GeneID" id="119733853"/>
    <dbReference type="OMA" id="NQCERED"/>
    <dbReference type="OrthoDB" id="6087056at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="5">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="246"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41685" checksum="EF7C84D32410AE98" modified="2023-02-22" version="1">MESSDDTKLGQSCSSDVNNDNNMPTTSAESPFNISQDSKTYYPETKLPIQDELHSVLDSILHMLNGSLKQEGEMLIMVTQTVIHLLKGLKEELDTRRELTRVERFSMKRFEGSDEDIKFWTGFYSYETLIVFYEHVCQNHASSLKYWMARNSQEEQANKRGPKCSFDPIDQMFMTLVKLKQGSGNKDIAERFKISDSYVTRIFITWINFLFNALVEGTNIWMSKGKVRKYMPAFFKGLYPDLQVIIDCTGISVERPSDLEVQAATYSQYKHGNTLKGLIGISPSGVTTFVSDLYEGSISDNELTMNCGLLDLCEPNVAIMADRGFTCKEAIMKRKLRHVTPHFLMGAAQMQPHQLVESVAVARCLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIR6</accession>
    <name>A0A914AIR6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063875.1">
        <property type="nucleotide sequence ID" value="XM_038207947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207947.1">
        <property type="protein sequence ID" value="XP_038063875.1"/>
        <property type="gene ID" value="LOC119734443"/>
    </dbReference>
    <dbReference type="GeneID" id="119734443"/>
    <dbReference type="CTD" id="286205"/>
    <dbReference type="OMA" id="HCIHPGD"/>
    <dbReference type="OrthoDB" id="525027at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65991" checksum="CC6916627AFDAAD5" modified="2023-02-22" version="1">MESLENSVEQPVAFPASDGQPATEEERKVVQEFSYLLEKSKQLFNGLRDLPQYGHKQWQSYFGRTFDVYTKLWKFQQQNRQALDTHYGLKRWQIGEIASKIGQLYYHYYLRTSETNYLNEAFSFYSAIRSRAYYSKVNREKGPELMVKKLRYYARLIVVCLLLRKLDHVKELTKELSKNVDEYKGHYDSEDQMEWALVLGEIEAFTEADDIITVLDTNSRAVTLTYRLAPGVLPGLDTGSPVYLTLQEALIVGNCQQQVKFSELTLDMYRMLQTLEREPTSSEHITSPPHHNDNNSKPLKRDNPHKYLLYKPTFSQFYTFLSAGFKELPVNAALLLYLSADGSAGLGKGEDAAFDSGGVATNNKREGNDQPVIKRSNMLKETHCIHPGDLYPYTRKPLFLVIDSPNSHAFKNFPNLFGQPVVCLMSPVSFPVTIQEQTTQKGNLFTMFLHSPLVAFCYICDIADVPIALWENCQAMVNKLMGEVATGIGKSKTIDHVFMQFYGDEFLRLLILRFIFCFAALRYHRGFKDDSFYPQSHPDLRGHDILECKTLHKHVLELASMLDVRPLFLDIGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJF7</accession>
    <name>A0A914AJF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038063690.1">
        <property type="nucleotide sequence ID" value="XM_038207762.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063691.1">
        <property type="nucleotide sequence ID" value="XM_038207763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207762.1">
        <property type="protein sequence ID" value="XP_038063690.1"/>
        <property type="gene ID" value="LOC119734324"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207763.1">
        <property type="protein sequence ID" value="XP_038063691.1"/>
        <property type="gene ID" value="LOC119734324"/>
    </dbReference>
    <dbReference type="GeneID" id="119734324"/>
    <dbReference type="CTD" id="8449"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="412"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="601"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1046" mass="120094" checksum="E3DEE1D586E48C37" modified="2023-02-22" version="1">MASQELNLWVQDSLHDILGISDRYIADYLIGIAGKASSAGDFVRRIQDTGTIDVNAATTKFAHELWGKLPRKASAKVANRAREQEAIARTKQSQSYKLLSDEEEELAVTHVAPTKREKREKGSKRKHIRKKKDESSDSDSDPQPVRTSKHAKREPSPDSESDEWDREEKERRQDLEERDAFAERLRNKDKEKTKNTADKGNKKAYEEARKRLEMAEQDRRKMIPELRKGSRRDYLKKRELDKLEELEADIVDEEYLFSSTELTAKEKRDLEYKRTVLKLAKDHKTAGEKQKEGRYYMPKEDEKPSDKYVEPMLDEQELGPRSEQQRWEEEHVKLGSMKFGARDAKQKHKTKEYDLVVDELGEIEFVSAIQMPGTRDKSEPEEPELSSAQKKRISIAETRKSLPIYRFREDLLQAIQDHQVLIIEGETGSGKTTQIPQYLYEAGYTKDGKKIGCTQPRRVAAMSVASRVAEEMNFKLGNEVGYSIRFEDCTSDRTILKYMTDGMLLREFLGEPDMAGYSVLIIDEAHERTLHTDILFGLVKDISRFRPDLKLLISSATLDTDKFAMFFDDAPIFRIPGRRFPVDLFYTKAPEADYLDACIVSVLQIHVTQPMGDVLVFLTGQEEIETCMEILQERVRKLGTKIRELIVLPIYSTLPSELQAKIFEPTPPGSRKVILATNIAETSLTIDGIIYVIDPGFNKQKSYNARTGMESLVVTPVSKASANQRAGRAGRVAAGKCFRLYTAWAYKNELEENTIPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPHETLVLALEQLYALGALNHKGELTKLGRRMAEFPVDPMLSKMILASEKYQCTDEILSITAMLSVNNAIFYRPKDKIVHADNARVNFFAPGGDHLTLLNVYNQWVETDFSTQWCFENFIQHRSMRRARDVRDQLQGLVERVEIPLTSASHDNIIIRKAITAGFFYHTAKFSKGGQYKTVKHQQTVMVHPNSSLFEEQPRWLIYHELVFTTKEFMRQVIEIENAWLLEVAPHYYKAKELEDMSSRKMPKNTGKSKEETRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJR4</accession>
    <name>A0A914AJR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PABC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063860.1">
        <property type="nucleotide sequence ID" value="XM_038207932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063861.1">
        <property type="nucleotide sequence ID" value="XM_038207933.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063862.1">
        <property type="nucleotide sequence ID" value="XM_038207934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063863.1">
        <property type="nucleotide sequence ID" value="XM_038207935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207932.1">
        <property type="protein sequence ID" value="XP_038063860.1"/>
        <property type="gene ID" value="LOC119734432"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207933.1">
        <property type="protein sequence ID" value="XP_038063861.1"/>
        <property type="gene ID" value="LOC119734432"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207934.1">
        <property type="protein sequence ID" value="XP_038063862.1"/>
        <property type="gene ID" value="LOC119734432"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207935.1">
        <property type="protein sequence ID" value="XP_038063863.1"/>
        <property type="gene ID" value="LOC119734432"/>
    </dbReference>
    <dbReference type="GeneID" id="119734432"/>
    <dbReference type="OMA" id="SRIYPKH"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PABC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="1">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="219" mass="24582" checksum="D3472E888D1CC373" modified="2023-02-22" version="1">MLPGDYDHLPDAKQILGEHLFTKVEELYPQQASHITGILLEAGNQEVMRMLQDEGLLRRRVEGAKRVIDEECAKTEGNCLEASAKDSLGEQLYFQVQQLGSHHCAKVTGMLLELSPDTINSLLASPQELQRAVRKATATLLQEQPEDGYRIEMDEEKQELGEELYCIIEEAHPELASKLTGMLLEMDATHLRQLLDHPDKLNEKVQLALETLKAACLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK21</accession>
    <name>A0A914AK21_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA polymerase II subunit 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Heterodimer with CHRAC1; binds to DNA. Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity. Within the complex, the heterodimer with CHRAC1 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction. Within the complex, the heterodimer with CHRAC1 interacts with BAZ1A/ACF1; the interactions are direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063968.1">
        <property type="nucleotide sequence ID" value="XM_038208040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063969.1">
        <property type="nucleotide sequence ID" value="XM_038208041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063970.1">
        <property type="nucleotide sequence ID" value="XM_038208042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK21"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208040.1">
        <property type="protein sequence ID" value="XP_038063968.1"/>
        <property type="gene ID" value="LOC119734506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208041.1">
        <property type="protein sequence ID" value="XP_038063969.1"/>
        <property type="gene ID" value="LOC119734506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208042.1">
        <property type="protein sequence ID" value="XP_038063970.1"/>
        <property type="gene ID" value="LOC119734506"/>
    </dbReference>
    <dbReference type="GeneID" id="119734506"/>
    <dbReference type="CTD" id="54107"/>
    <dbReference type="OMA" id="KEISHAN"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000041">
        <property type="entry name" value="DNA polymerase epsilon subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="12">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="201" mass="22703" checksum="B9399E57810E59FD" modified="2023-02-22" version="1">MAERPEDLNLPHSVITRIMKEAVPEGVSVSKEARNAVSKAASVFVLYATSCANNYALKGKRKTLNAADVFAAMKDMEFEEFIEPLEKSLQEFRHEQKGKKEASEKRKQNRSDAEKAEGEDSEQNISSEMEDSREDAEDEEDVEGEEGEDEDIDEDIDDEDDDEEDIDDEEDGEDVEEIEDDGEENVGQVEDVDDDDVQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKM4</accession>
    <name>A0A914AKM4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063974.1">
        <property type="nucleotide sequence ID" value="XM_038208046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208046.1">
        <property type="protein sequence ID" value="XP_038063974.1"/>
        <property type="gene ID" value="LOC119734510"/>
    </dbReference>
    <dbReference type="GeneID" id="119734510"/>
    <dbReference type="CTD" id="4716"/>
    <dbReference type="OMA" id="CKPILEQ"/>
    <dbReference type="OrthoDB" id="6017729at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="150" mass="17637" checksum="6133E3CFE0B0028E" modified="2023-02-22" version="1">MGVLDEFIGKAFYYTIDAPVTFVRDFVEQQQNKRPYYYYHRQYRRVTPVEDCNTDDYVCLYEAEMQYRRDRLVDQQIIIQLQEMVGECSTREGPNAKSACRPLLDEYDEAATNYDIKYGGLGAAGNAVRCMMKQKHRMLEDRRKAKEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL97</accession>
    <name>A0A914AL97_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038064348.1">
        <property type="nucleotide sequence ID" value="XM_038208420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208420.1">
        <property type="protein sequence ID" value="XP_038064348.1"/>
        <property type="gene ID" value="LOC119734840"/>
    </dbReference>
    <dbReference type="GeneID" id="119734840"/>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008489">
        <property type="term" value="F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF38">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="231"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="335"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="491" mass="56971" checksum="DA20E5B400F45C1C" modified="2023-02-22" version="1">MKHKSYLHRLLQKMFASFFYNLILVTKRSVELTRKACQKWGAVQHNGGPMTLGVGTVTKPCFLTEKLVDFQAVFWLLTLLATASTLMLWFSVSTLYGVEQDGGEHGFSHWLTRLRRSIDLVSDPNQRVSIRSKDIRYGETDELCEESDFAGSDGNVTLHMNWTELYHAEEEVLRTSTNSIRNYLKTDNKLVQSMYFDAAHGGRRPRRKQPPTSVADALSEGVLIDDYYYVSGGHWIPATCHPRWKVAVIVPFRDRYFQLPIFLRNIVPFLKRQKLEFGIYVIEQANELEFNRAMLMNVGFQQALNFTHWDCFIFHDVDHLPLNDANYYGCSHMPRHFISGADRWNYKLQYSFFFGAVTGFTRSQIQKFNGFPNAYWGWGGEDDDILIRIQANGFFKTRPWGVTGFYNVIAEHHKSAPKNKKRVCLLDYARERLKTDGLSNLIYPPVRVSLTPLYTNIAVNITNLAWNPAWTVCTRDYRRAKKEEVVGWKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMC6</accession>
    <name>A0A914AMC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065180.1">
        <property type="nucleotide sequence ID" value="XM_038209252.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065181.1">
        <property type="nucleotide sequence ID" value="XM_038209253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209252.1">
        <property type="protein sequence ID" value="XP_038065180.1"/>
        <property type="gene ID" value="LOC119735523"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209253.1">
        <property type="protein sequence ID" value="XP_038065181.1"/>
        <property type="gene ID" value="LOC119735523"/>
    </dbReference>
    <dbReference type="GeneID" id="119735523"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="37765" checksum="9322783CF7DBF9D6" modified="2023-02-22" version="1">MDKYVTLEEYKGMVQKMQPMMVHANIPPRQKPMVDGIVFPPGTDQIVSDLKNFEVREDDAWIVTYPKAGTTWTQEIMSCVMHDGNLEEVNKRHTVFRVPFLELCLPEPVLKMKNMPQIHKIVAEMPSPRVIKSHLPGQLLPPQMWTKKPKIVYVMRNPKDLVVSFFYFTRMMNRSPQKQAESFGDFFELTLEGKTMFGPWWEHYLYFWRKRHEPNILLLWFEDMKRDLRGIVEQISQFLGKSLSAKTLDAITEHCTFANMKKNPMANPDTIFENTGGQDTGEKASFMRKGKVGDWRSHFTVAQNEAMDALMKEKLHGTGLNVDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMM1</accession>
    <name>A0A914AMM1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064987.1">
        <property type="nucleotide sequence ID" value="XM_038209059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209059.1">
        <property type="protein sequence ID" value="XP_038064987.1"/>
        <property type="gene ID" value="LOC119735359"/>
    </dbReference>
    <dbReference type="GeneID" id="119735359"/>
    <dbReference type="CTD" id="10311"/>
    <dbReference type="OMA" id="CVTMPIT"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000008">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="35087" checksum="5218C6A541C47095" modified="2023-02-22" version="1">MNIQAELEILFHGRRHLACRVGPTCCSFRILRAATLKDVLAGLVVVQSKSDVQHQGITLVVDGSVNLQLSSKNVGLFEAFYNSIKPIQLLNYVVNVAKPGKIPAGKTEIPFELPLKPKANKNLYETYHGVFVNIQYTIKGEMKRPLLAKDLTKSIEFIVEYKDQKEKAQPKPVSFAITPESLQNIKDKGGLPRFSIKGKLDSAICCIKNPLTGTVVIEYCDAPIKSVEIQLVRVETCGCAEGYARDATEIQNIQIGEGDVCRGITIPMYMVFPRLFTCPTLATSNFKVEFEINLVVVLQDDHLITENFPVKLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN62</accession>
    <name>A0A914AN62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
            <ecNumber evidence="4">4.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dihydrodipicolinate synthase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Probable 2-keto-4-hydroxyglutarate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step in the metabolic pathway of hydroxyproline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038065460.1">
        <property type="nucleotide sequence ID" value="XM_038209532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209532.1">
        <property type="protein sequence ID" value="XP_038065460.1"/>
        <property type="gene ID" value="LOC119735679"/>
    </dbReference>
    <dbReference type="GeneID" id="119735679"/>
    <dbReference type="CTD" id="112817"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:(R,S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="13">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="337" mass="36922" checksum="50CA13F637E5F6E4" modified="2023-02-22" version="1">MAAALVRKLVFEVPVLRCRRLTSISQCLISRTGLRTMATGVKVDLSGVFPPIVTPFDEKENVNYDELTNNLQRWNSMPLRGYVVQGSNGEYVFLNKEERVEMVRRVRQATPADKLILAGSGCESTRDTIEMSKMMGDAGADALLVVTPFYFKSMMTSEALINHFTKVADNSPVPVILYSVPANTGLDLPVDVAVALSKHPNIIGMKESGGDVTKIGLIVHQTKDNNFQMLAGSAGFFLQSLSVGAVGGVCALANVLGREVCQVQTFFSDGKMEEAMKLQHRLIEPNSAVTKRFGVPGLKTAMEWFGFYGGPVRNPLLPTSEAHKEQLREAFTRNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APL8</accession>
    <name>A0A914APL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065975.1">
        <property type="nucleotide sequence ID" value="XM_038210047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210047.1">
        <property type="protein sequence ID" value="XP_038065975.1"/>
        <property type="gene ID" value="LOC119736047"/>
    </dbReference>
    <dbReference type="GeneID" id="119736047"/>
    <dbReference type="CTD" id="51463"/>
    <dbReference type="OMA" id="FSVYCVY"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="279"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="52875" checksum="E28035FCAD265172" modified="2023-02-22" version="1">MAFFLDSFVMFTTQILFFLGGWIFFMRQLFKNYEVRHVIVQLVFSATFALSCTLFELIIFEILGVLNTNSRLFHWKFDLYAILFILIVILPFYVAWFIFTNIRIVQNRHLTFPLTLGAWLVFVYFFWKLGDPFPILSRKHGIFSMEQVMSRIGVIGVTIIAVLSGFGAVNCPYTYMAYFVRDVSDADIQAHDRKLLQVMDMILTKKKRILLIERDQLQQASSNRKQASGIWGMLKSVATSSGGANLGQLQQEVAGYEELSRQLFLELVDLNSTKERIEYSKTLKGKYFNIMGYVFSMYCLWKIVICTINIIFDRVGKTDPVTKGVEIAVHWLGIEFDVTFWSQHVSFILVGIIIVTSIRGLLIKLTKFFYTMSSSKSSNVIVLLLAQTMGMYFVSSVLLMRMNMPPQYRMIITEVLGDLQFNFYHRWFDVIFLISALSSIAFHYLAHKQTGEKPVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS80</accession>
    <name>A0A914AS80_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066513.1">
        <property type="nucleotide sequence ID" value="XM_038210585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS80"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210585.1">
        <property type="protein sequence ID" value="XP_038066513.1"/>
        <property type="gene ID" value="LOC119736570"/>
    </dbReference>
    <dbReference type="GeneID" id="119736570"/>
    <dbReference type="OMA" id="MEMGKPN"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="22750" checksum="E6E44492D1B16DDF" modified="2023-02-22" version="1">MSVRRRRPQRSPGQDHSRTSTPSPSPSRSSSISSLSSSSSPSIQALRCPPQGTESERKLKLATIHKALTADPVDVAALRKLAISKGGLLTDDVRRKAWPKLLNVNLFDVPYKKGVKLESHRDYHQVVLDVNRSLKRFPKGMRDDQREALQGQLVDVIVRVLMENEQLHYYQGYHDICVTFLLVVGKEAAFALVHKLSTHHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATF9</accession>
    <name>A0A914ATF9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066631.1">
        <property type="nucleotide sequence ID" value="XM_038210703.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210703.1">
        <property type="protein sequence ID" value="XP_038066631.1"/>
        <property type="gene ID" value="LOC119736688"/>
    </dbReference>
    <dbReference type="GeneID" id="119736688"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038047581" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1584"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="769"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="911"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1007"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1176"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1277"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1475"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1750"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1922"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="2037"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="2218"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1612"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1660"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1683"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1708"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2309" mass="252279" checksum="B03292CEAAC2022C" modified="2023-02-22" version="1">MEDRLNFIVLLLLLGLFKGVSAVIDFTCITKPRIDIDSEDTYIAAYLHGSDAALSFARTTYTYTSVDNIKDQLGLPSDHDLEPHSSSEGDKISILRLPAAGGKTRIGFFACRANQETHSIGTLIMNRNADFLPTRVSHTVNRGDAVNLTVTATDQTRTKTKWRKDSSDPIKGRDKLFFSFTNAQVRDSRNYEVHFAGQRSTGKQALMRLIVRACLEKKWNSHSCSADCPVCFNGGVCDDQSGDCICPPGFSGDFCETPEGPNRFGQSGSFRCDSPELGEGPTCAGMLFCLPDPYGCSCASGYQGIDCDDSCGDGFYGADCAQTCHCMDGAACNITTGECPEDCAPGFAGINCQVKLTVDDFTCVTKPRIDIDSGDSYIAAYLHGGNANLSFARTTFTYTGSESPNPPVPPATLQLPNNSVGTTSSSAGNKISVLRLPAAGGKTRIGAFACRATAAGTDPYNIGTVIMSSKADYLPTQVSQTVHRGGAVTLTVTATNPARTDTRWRKDGSGVILNRSDSLYFDFINTNVLDTGIYEVHSAGKRNHGNQALMRLIVRGCGRNIWNAPSCDSDCPVCLNGGICDDRSGVCICPPGFGDRFCEIFLGRNHFGQSGSFRCDSPELGGGPTCAGMLFCLPDPYGCSCAAGYQGIDCNETCGDNTYGADCAQTCHCKDGVACDKSTGECQGDQDCAPGFTGINCQEKCLPSRESSSSCDKTCTSPPVPLPVSELAVAGTYIDKLFVSWRASTSPENPCRSEDYLVTYELLSRDQLPLVAPEVHSIDPAPDSIMFNWYPIPCGSTRGNITSYETRLTSPGREINTKTVTTESVTFHGLSPCSLYTLRVWPRTKAGRGPPVEVQQGTDTIEPLPVSELAVAGTSIDKLLVSWRASTSPENPCRSEDYLVTYELLSRDQFPLVAPEVHSSDPASDSIMFNWNSIPCGSTRGNITSYETRLTSSGRVIGSKNVTTEFVTFDGLSPCSLYTLRVWPHTKAGRGPPMVEHQRTDTIVPDAVGELSIKAVRHEQLNVNWKASTNRDTSCPATEYLVTYELINLEQCQEMQGNIQTRNTSTTAISLQGLKAYSKYNVTVTPRNEAGLGQPLSKQKRTRWTATTATPVNITIVATPDSISFAWDPVPCGRRGEPLRGYGYQLRKDGNKETIRSRNISADSVTFYPLSAFPDAVEGLTITPLGHDRLGVQWNASSNTNNDCHATDYHVTYELINLEQCQEAPDHDVSATNVTVTNITINGLHAYSSYNVTVTPRNEAEYGPMLYQTVQTGEKKPTGTPILGESTASSDNITFTWSQVPCGGRGGNITKYRYKLMKRGNATAIEKEDTTATSVTFRDLSPCTSYAFRVRAFNGERKGPWTNESYQDTVVIDEIQDLNLDASVNEIKASWTTAGNEDNPCPVTSYRVSYQLLNLEQCQPQIDPALTSATVQNGSDKDITSMHAYSTYSVQVVPANNAGAKYMKNKTVTTDEGVPLAAPVLNNMLPSSQNVRVSWHPIPCGKRGGNITGYTYELRDASGSMIQTADTTAESVEVDGLSQGASYSFRLWASTHVGPGPWREDDFEIPKDAAAPPTPPGSSPAGSVLGVVVFILVVAVLALLIVVVVKKRRKQRTNALSKDSTGDGVQDIYGKGDQGGVELKNLPSTSGYKPYATKGHEPVVSSTNPPKSTDQVAVDVLPKAGPSTDSASASGPSTSTKAPVKPKPYVNPASKPKLKASAKASPSFPQAGPVAMAHLAEYIKSRTAGKINGFQQDYESIPGEPIHPWNVAKQDHNKKNNRYNNILAYDHSRVVLECLEDNPHSDYINASYINGYKQDYKYIASQGPTKASVKDMWRMVWQERVGKIVMLTNLIEHGKGKCEQYWPDGSSDYGELFVRKVDETKHSNCIVRTFHVSKSTEPEGEYRELTQFHYTTWPDMKPPESSPLLQFVRRVRAADASQHGPMVVHCSAGVGRTGTFITLDSMLEMAEAEGQVDVLKFVRDMRDQRFLMVQTLDQYKFIFDALLESSLLENTAISADCFHQSYAKLKKRDKKTGTTGIEAQFQMLESFTASPSEEQCMGGRSAANVDKNRFKECIPKDSTRPYLMTKGDERSTNYINATFLDGYNSKHAYLATQAPLPNTRGDMWRMVFDYKASCIVMLNSMDNDPSVVQYWPEKDSLEFGPLTVTLTNEDRYSEDIIIRQFDVSYPARKNDEVQSVCQIQYLGWPPGKEVPRSPSSLLKVLEAVKMWTTDHPDGPITVHCIDGVGCSGTFCAILTLLDQLAVEKDVDVFQAIKKLRITRAGMVNTLAQYQLCYQVIQTYLDSGSIYENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATK3</accession>
    <name>A0A914ATK3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067102.1">
        <property type="nucleotide sequence ID" value="XM_038211174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211174.1">
        <property type="protein sequence ID" value="XP_038067102.1"/>
        <property type="gene ID" value="LOC119737084"/>
    </dbReference>
    <dbReference type="GeneID" id="119737084"/>
    <dbReference type="OMA" id="VISDCIG"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21050">
        <property type="entry name" value="ELD_TRPML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000033">
        <property type="entry name" value="Mucolipin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049134">
        <property type="entry name" value="MCLN_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21381">
        <property type="entry name" value="MCLN_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Mucolipin extracytosolic" evidence="16">
        <location>
            <begin position="132"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="15">
        <location>
            <begin position="425"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="622" mass="72319" checksum="8EA9367C76F9567F" modified="2023-02-22" version="1">MSNSLHMSIVKAQTGMNTAAKRHNGPAMANHHHGHHSHESHESSGNDCIQEEGGMQTELISNHYGSGGYDYGAPPAVEEKMRRDLKFFFMNPYEKYKARGRKPYKLGLQIIKIVFVTLQLILFGLNQFTQATFFEDNEKAFNNIFLKDWDPTYDSFAYPKTRQLYALYLKEGVYEHLDYAVYKYSQLERIAVGTYEFETAQSRDIHNMTLCNRHFLNVNLSNGKFDVNASTKTDCLTFEVSPDKNISMQQFLKDNDFTMSFDSMIQMQLKFSIRSLHIKDLAMFLNPDCVRFNITILYDYSIHGGRIAVSLSEQHSIFNCSNKVVGEEEAHVISYLVAAYDIFIVFLCLLSLLLCCRSLQRGRRLKKRAKTFFKRYYDRKLTRLEKLEFLNFWYIMIIISDLLTISGSIVKLLLEWLITTDYDVCSILLGTGCFLVWLGVLRYLGFFPKYNIPIITLKSAMPNCLRFMVCGVILYMAYGFCGWIVLGPYHHKFRSFNVAIECMYSLINGDDMFATFDEMSDKSTVVWVYSRIYLYTFISLFIYVILSLFIALIMDTYETVKACQGRHRSHTELEAFIDQCDDRPESGCYRRKKKKKRRKTWKSLCNCRRSSSSSDETTPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW95</accession>
    <name>A0A914AW95_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 5 OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067973.1">
        <property type="nucleotide sequence ID" value="XM_038212045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW95"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212045.1">
        <property type="protein sequence ID" value="XP_038067973.1"/>
        <property type="gene ID" value="LOC119737589"/>
    </dbReference>
    <dbReference type="GeneID" id="119737589"/>
    <dbReference type="CTD" id="91875"/>
    <dbReference type="OMA" id="DECKGYE"/>
    <dbReference type="OrthoDB" id="423589at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032076">
        <property type="entry name" value="TTC5_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038645">
        <property type="entry name" value="TTC5_OB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16669">
        <property type="entry name" value="TTC5_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 5 OB fold" evidence="4">
        <location>
            <begin position="313"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="435" mass="48590" checksum="3EED8E45D592445B" modified="2023-02-22" version="1">MAANEKDEALGRIQKAVEDLYAFRDHFFEKNSIDRAIHKTEELGQELKKVIELLDELQSQIKNRSEYMLQRGKALNVLPDFSPESLECLSKAVKLDPRSVEAWNQLGECYWKNKDVEAARNCFTGALNHSRNKVSLRNLSMVMRQLGKSQEERSKFIQDSVDHAKEAVQMDYSDGTSWFIAGNAYLTVFFNGGQKSSILKQCLGAYSQAEKDTIQKSNPDLYFNRATIFKFQEDYQASLDGYRMAQSLDPTWPEPKEKLSELVTYLQNVTQLVQQKGKLKAKRLQQLLASIKETDLGPYGGGSYTPPKGDPVKLELMPLSRLAAGPNPEKVVHGKVVCSVATDEPIPFTFAMVDAEGSCFAVNIYNIAKGQGVIIGDSVAVPEPFVQHNDFVFDKTNVKFSSIRVDTPVALVVNGKKLGLEKQAPAVVSLYAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWI3</accession>
    <name>A0A914AWI3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067864.1">
        <property type="nucleotide sequence ID" value="XM_038211936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWI3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211936.1">
        <property type="protein sequence ID" value="XP_038067864.1"/>
        <property type="gene ID" value="LOC119737516"/>
    </dbReference>
    <dbReference type="GeneID" id="119737516"/>
    <dbReference type="OMA" id="QNRAWAS"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12681">
        <property type="entry name" value="RRM_SKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034784">
        <property type="entry name" value="PDIP3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF96">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="483" mass="51992" checksum="075006F095DD4C85" modified="2023-02-22" version="1">MADKSLDEIIQERKIGGSRGRGRGRGAFRGGRGGNVVQSGRGRGGGRVQKTGGGNFQVAMPNRSQVIQSLMRQNAFRPNQAIAVTVPDAREKLIFKARQTDAREKLNKKAKLVDVRVKLNARRQKGQQQQQQQQQQQQQQQLSGGDGPMMQGVVPGSQLRNLGKKKLNEITINNPSATKQRQMTGPTQFTISNTPTRTPKGKGGANNVRVSVGAEGLQVTTVNKSAQKRQARQETLQLQRSVPVVDNSLEEDLIFQPVSAKFKKIAAQAPPPPQTNIKTTIQDGMHAVGFSARDLGSPFQLGNAQQKSALQRVAAQPPLSVAASTQGTRLIVSNLHSSVSEADIKELYGDVGALKKARLVRSGLAEVVYIKREHALEAIARYHNRELDGLPMQCKLDTSTVPEATGIHVPASGKMSMNERFKLIGAGASGMTDFSLSTVGMRSDAMAPSSNDSVEAATVHKALFKTGASTTASSRPVVFTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZS0</accession>
    <name>A0A914AZS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038069019.1">
        <property type="nucleotide sequence ID" value="XM_038213091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213091.1">
        <property type="protein sequence ID" value="XP_038069019.1"/>
        <property type="gene ID" value="LOC119738263"/>
    </dbReference>
    <dbReference type="GeneID" id="119738263"/>
    <dbReference type="OMA" id="AHSMPQT"/>
    <dbReference type="OrthoDB" id="10059453at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="109"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="871" mass="96868" checksum="79CD36ABCB52F62E" modified="2023-02-22" version="1">MSKKSTPSKAGVTYRTSSRRNGWSCPPHPLQFVAWIFIAAFAVMFHGMAVPTIPYHWQPACHMIVGVVLAVHVITHLVCLTINPADPSTLRRDKKAMPEFDRTQHKHVIENNHCYLCEVDVGLRSKHCSSCNKCVADFDHHCKWLNNCVGSRNYRWFITCLGSAFLCCLFVFAVFLYISIVYWVNPKLLHPELYDGAATTQPTVTAEELTTSQLLNSSASPTTDISDPLVAYRSGLRIFGEVSGTAFFVVAIVLAVLLLVTLCLLGHLLGFHMFLICHDMSTYDYVMQDRNAFISGDVEAQQKKPKKKGCCKCNNQVAPLQEAKEEIEMTDTKKDSTTSQLESNNNSNSNLQQQLVISEPLIKQKEQQQDKQEPQSVTVTDSKPKSKKKKKSKKKSQRMRSLTARESLQPALMGHPYPPSQMNLANSMPQTYLEQHLVRRFSLPLVTPAGMHPQYPVAEPVEDLFFTQQFPTVQRPITNPQDGQARQWRPIPPPAAISFDSPTPAVDYHSSSAESLVEIPLGRAYHRGSFSHPAQKALLPGGNQLVTGYQHPLEKRHLSHNSHPNLTTSGNQQQPDIKQLGAGVTHLESNTNNMSHLKKSKRTSARTKKGEMSNVSPAAGPLNEIERTKRHSIKEPLLVQTAQEAESQIVPDAERLNKKTGNSGRRAKKQRSPQSVETTAEVHRQLDDQSEVAMQSSHDSRQRRMPGQDQEAKVDIDPHLQDRTTSDARTQNGQAPPPKAAPVAAPRRRTLKLGQEPSGSQTSLHSSSSRQHLLEDADGDSNRPSSGRSRKEQLQENGSHDAVSLPGSIPEVPPLDLGPLADTHDSKAASVTHRPPSDRGSLSDEQLVEGYSSEEMNSMPMSRRRSLLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1Y7</accession>
    <name>A0A914B1Y7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070022.1">
        <property type="nucleotide sequence ID" value="XM_038214094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1Y7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214094.1">
        <property type="protein sequence ID" value="XP_038070022.1"/>
        <property type="gene ID" value="LOC119739238"/>
    </dbReference>
    <dbReference type="GeneID" id="119739238"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF10">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="19434" checksum="F3284BC2FB241322" modified="2023-02-22" version="1">MRLQVETSKKKLKSFLDPKVAQNLGIFLAGFKMDAEELKFRLAIVSENNGGLGAEQINMLRRYYPTAEDMETYRKFKDRQAELEHADQFMLQLCEIPHLKTRLDVLMVINELPVQYEDLAPHQVNKSLPTISVKSSQVKSSLQVTSSLQVASSRVKSSQDKSATTHQDRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B376</accession>
    <name>A0A914B376_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069951.1">
        <property type="nucleotide sequence ID" value="XM_038214023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B376"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214023.1">
        <property type="protein sequence ID" value="XP_038069951.1"/>
        <property type="gene ID" value="LOC119739189"/>
    </dbReference>
    <dbReference type="GeneID" id="119739189"/>
    <dbReference type="OMA" id="FYMFPPN"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="407" mass="45375" checksum="AE98187ED1F03555" modified="2023-02-22" version="1">MSGADRWYEYVVVGCGGIGSSAVYWLAKRAGQNVLGLEQFKLGHDHGGSQDHSRIIRLSYSDPLYTKLAAGAYACWDEVEKESGLQLVYKTGGINFSRRGGLAEKIVDRYAESMQENDIEFENLDGLRLHERFPQFSASDNYRAVYQKDSGLVDAALANAVHTQLARKHGATILEETKVERFEKTKDGSYRVFTNRGTFRCRRLIITAGAWLKGVLSSVGVQLPLTVTQEQVLYLATPNISEFTKSRYPIWIYHTDNGDFYGMPIHGNSGVKIGVDVGGDHVTVETRTYIPNQTRLQQCLDFSREHIPGSLGPILYAKTCLYTMPPDRHFVIDTCHRTNHPDAIVCCGAGHAFKFASVLGRVLSELSIDGRTEYDISAFNLGRPALHDPSFKPLFQLGITKLQEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4J6</accession>
    <name>A0A914B4J6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071201.1">
        <property type="nucleotide sequence ID" value="XM_038215273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071203.1">
        <property type="nucleotide sequence ID" value="XM_038215275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215273.1">
        <property type="protein sequence ID" value="XP_038071201.1"/>
        <property type="gene ID" value="LOC119740072"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215275.1">
        <property type="protein sequence ID" value="XP_038071203.1"/>
        <property type="gene ID" value="LOC119740072"/>
    </dbReference>
    <dbReference type="GeneID" id="119740072"/>
    <dbReference type="OMA" id="VHYVVTQ"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF384">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57720" checksum="93C7949EF5AD050B" modified="2023-02-22" version="1">MTPDTPMIGTVGQYIVPLALPLLLPMVLLLVMRRLWYEYFFLSRDPAFDTPLPDGGMGWPLIGETISFALQGSDFYDKKFQQHGRIFKTHLFGRPTVRVRGADNIRKILHGENDIVTSYWPTTTRIIFGSDCLSQSQGPYHTRLRKHVASAFSHTALSGYVSLVQPLIIETINDWCKATNGVAVYPECRALTFRVAGKVLCGFDCSKSETASLIDYFEDIVYCLFCLPINIPGGGFNKGLKARDLIAKRIKENILRKMDNDDTQDALRILMEQDTETGEIPSTPAIVANAIDLLVAGYASTASAACSILRDLHNNKHVLARVRRELADHGMTQAGSPLSLEDMNQLKYVSNVVKEILRMSPPIGAAFRKALRTFELDGKQIPAGWTVLYSIRETVGLSDTFADKAKFDPDRFSSERCEDRNGDRYNYCIFGGGPRSCIGKSFAVMLMRMMVIELARSCDWELLKPDSLKMTQLPTPHPVDGMPVKFTALNNVDHNSNSFVFTECESENASDSIQSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5A7</accession>
    <name>A0A914B5A7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071263.1">
        <property type="nucleotide sequence ID" value="XM_038215335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5A7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215335.1">
        <property type="protein sequence ID" value="XP_038071263.1"/>
        <property type="gene ID" value="LOC119740130"/>
    </dbReference>
    <dbReference type="GeneID" id="119740130"/>
    <dbReference type="OMA" id="FFYGKRN"/>
    <dbReference type="OrthoDB" id="10013074at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF5">
        <property type="entry name" value="ISOTOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="25672" checksum="FDDC5D8273D599BE" modified="2023-02-22" version="1">MGGRSVSLIGVVIVVVTILVAFTWAETANGSLSQKVKIRREGRESDKYWSKDVGLTDQQLRQLLANSLTNSYSTGEGESQTRPAKPGYRLYGNRLSDTNLGIDGNEEDEVETEVTPRGSALRTSKRNGFFYGKRNGFFYGKRSGSTLENANQCTQCGPQNSGQCVMFGTCCSYAAGGCFFMTEEALPCVTSKTSSICQLQGAPCGSDGYGRCVADSVCCSPQEGACHVDVACSSKPTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5D1</accession>
    <name>A0A914B5D1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Phospholipase A2</fullName>
            <ecNumber evidence="2 14">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_038071154.1">
        <property type="nucleotide sequence ID" value="XM_038215226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5D1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215226.1">
        <property type="protein sequence ID" value="XP_038071154.1"/>
        <property type="gene ID" value="LOC119740033"/>
    </dbReference>
    <dbReference type="GeneID" id="119740033"/>
    <dbReference type="OMA" id="TDEIDWC"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF47">
        <property type="entry name" value="PHOSPHOLIPASE A2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038156031" description="Phospholipase A2" evidence="14">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="15">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="159" mass="17392" checksum="74FF3E7C36A72C82" modified="2023-02-22" version="1">MKLLLIMLGLVAISSARGIGQRSLTQFASMYSCTVGLGYMDAVGDYFGYGCYCGAGGHGTPVDDTDECCAVHDKCYEDATSNGCSALQIYYITYDYEKTTASDGSCQLSCKAQADYDSSDNDAQCRAYMCNCDRKGSECFAKNRPTYDKKYKGWLSLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5N4</accession>
    <name>A0A914B5N4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein COX15 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070786.1">
        <property type="nucleotide sequence ID" value="XM_038214858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214858.1">
        <property type="protein sequence ID" value="XP_038070786.1"/>
        <property type="gene ID" value="LOC119739786"/>
    </dbReference>
    <dbReference type="GeneID" id="119739786"/>
    <dbReference type="CTD" id="1355"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51603" checksum="370D7BABE341C81C" modified="2023-02-22" version="1">MALRNAWRSSLNFHCNRQCLIQGFSFASRFCSRKPRHVLDVIHQNAMNVRHTTSSALSCTKRLGQFFKLPQLSRLYSRYPRSQQIFQHASRRFQSNGVAEAQPTAAIPAHAQKIVGWWLLGCCGMVVGAVVLGGVTRLTESGLSMTDWHLIKGMKPPRTQEEWQAEFDRYKQFPEYKYVHRDITLDEFKWIWRMEYGHRMWGRTIGLVFLLPAAYFWRKGWLTKAMKPRVLIYGSLLLFQGLLGWYMVKSGLQEPQPTDMPRVSQYRLASHLGSAFALYALMLWSGLSHVLQYKPIADSRYLPLLRKCAHGTMALVFVTALSGAFVAGLDAGLVYNSFPKMADKWVPDDIMAIQPKYKNVFENPTTVQFDHRILGTTTASAVVGMWLLARKVPLPARANLAVNCMLAMSAAQITLGICTLLYFVPTELAAAHQSGSLTLLSLAIWFAHEIRKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6K5</accession>
    <name>A0A914B6K5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071753.1">
        <property type="nucleotide sequence ID" value="XM_038215825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215825.1">
        <property type="protein sequence ID" value="XP_038071753.1"/>
        <property type="gene ID" value="LOC119740503"/>
    </dbReference>
    <dbReference type="GeneID" id="119740503"/>
    <dbReference type="CTD" id="24144"/>
    <dbReference type="OMA" id="CEQDIIQ"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="810" mass="93941" checksum="9A9B0E3A042FFE8E" modified="2023-02-22" version="1">MDSDKDEKEDFEITDYDLLNEFNVDRPTRRMTKAQAIYGVWADSDDETDERQGFGTTGQRSKRDLNFISSEIRGGEQQKDDKQDDKASSISYQLPLRPEGSSKGQSSKVMTNAQKSHASLMKSDKQFGNWQKHTKGIGQKLLLQMGYIPGKGLGKANQGIVRPVEATKHKGKGAVGANATSQYVGRRGGREPEAVDSEEEEDTQFREELARWKKGEVTMQKTKYVYRTVEEVKKSAHLTKRKKADPTARGVKVIDMTGPEQRVMSGYSHLGKQHDKPTERLEVEGMEGKKSAFEMPELEHNLQLLVEMAEQQIIQHDRQLHHEEDMVVNLQHEQGKLRAVLNQEERQISHLEKIMEIVEQCEERSKPGCPNPLSLEEYEDIFKTLQTDYREEYRAFELSQLATVNVLPLIKKELTSWDALRDSNKHVDLFKKWKDMLDSDDSRFLLPNGKTMTVYERLSWEIWMPQFRRAITNWNMRECDPIIDLLENWLPLLPQWLLNNILDQLIYPRLQETVDEWNPLTDIIPIHAWLHPWLPLMGDKLEPLYIPIRQKLARALSNWHPSDSSAKTILIPWRRVFSRGTFEAFLVRNIVPKLAVCLQEFVINPYDQHLEPYRWVIDWEELLPTPTLASLFEKHFLPKWLQVLCSWLGNNPDYEEVSKWYLGWKGLLPERIREEPAVKVYLKDALDVMNQAVSGSHPVREADSMAYVNSLRQQREATSSNRWEPEPQQARQTSVPTISVPTNFRDLVEKKASENNLVFLPTNRRHEGKNVYMLGPLNIYIERSVVYVHQGHVWTPMGLQTAIELAQNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6W6</accession>
    <name>A0A914B6W6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071560.1">
        <property type="nucleotide sequence ID" value="XM_038215632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215632.1">
        <property type="protein sequence ID" value="XP_038071560.1"/>
        <property type="gene ID" value="LOC119740362"/>
    </dbReference>
    <dbReference type="GeneID" id="119740362"/>
    <dbReference type="CTD" id="1938"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="840" mass="94054" checksum="FF5BBD674A9DC4BF" modified="2023-02-22" version="1">MVNFTIDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGARAGEARFTDTRKDEQERCITIKSTAISLYYELAEADMQYITQEKDGNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVVFMNKMDRALLELQLEMEDLYQTFQRIVESINVIVATYADEEGPMGDIQVYPYKGTVGFGSGLHGWAFTLKQFAEIYAAKFKIEPAKLMKRLWGDQFFNPKEKKWNKIGGEGYVRGFNQFVLDPIYKVFDAIMKFNKDATQKLLDKLNIKLSTEAKEKEGKPLMKEVMRKWLPAGEALLQMITIHLPSPVTSQRYRMELLYEGPHDDPCALGIKTCDPTAPLMMYISKMVPTTDKGRFYAFGRVFSGRACTGQKVRIMGPHYVPGKKEDLYQKSIQRTILMMGRYIEPIEDVPCGNIVGLVGVDQYLVKTGTISTYDQAHNMKVMKFSVSPVVRVAVEAKDPSQLPKLVEGLKRLSKSDPMVQCIIEESGEHIVAGAGELHLEICLKDLEEDHACIPLKKSLPVVSYRETVETASDRMCLSKSPNKHNRLFLTAVNFPDGLAEDIEKDEITPRTDAKVRGRFLADKYEYEVNEARKIWCFGPEGTGPNLLIDTTKGVQYLNEIKDSMVAGFQWATKEGVLCDENVRAVRFNIHDVTLHADAIHRGGGQIIPTTRRVLYACMMTANPRIMEPVYLVEIQCPEQAVGGIYGVLTRRRGHVFEEGKVAGTPMFMVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQIMPGDPYDVASKPGVVVTVTRKRKGLSEVPPPLDKYLDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7J5</accession>
    <name>A0A914B7J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072143.1">
        <property type="nucleotide sequence ID" value="XM_038216215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216215.1">
        <property type="protein sequence ID" value="XP_038072143.1"/>
        <property type="gene ID" value="LOC119740789"/>
    </dbReference>
    <dbReference type="GeneID" id="119740789"/>
    <dbReference type="OrthoDB" id="5970825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15299" checksum="DD705198760685C7" modified="2023-02-22" version="1">MEGAKAAIEAKKAEWKRHFEENNLKAIGEIYAVDCKLLPHGKPTVHGRHDIPDGLKELRMKGTTSLSWETDELGPMTGNGDVIFELGNYKFLKSDGSSVTEGKYVHLRKAQTFQKHYSFIHHLRHRTFLYSAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7K3</accession>
    <name>A0A914B7K3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CF-1 77 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleavage stimulation factor 77 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072153.1">
        <property type="nucleotide sequence ID" value="XM_038216225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7K3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216225.1">
        <property type="protein sequence ID" value="XP_038072153.1"/>
        <property type="gene ID" value="LOC119740798"/>
    </dbReference>
    <dbReference type="GeneID" id="119740798"/>
    <dbReference type="CTD" id="1479"/>
    <dbReference type="OMA" id="CFRGPFV"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000002">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002655">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="664"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="714" mass="82522" checksum="506B04036EAC54A8" modified="2023-02-22" version="1">MASEPRSELFTGWGYIPEKVKKAQKKIEMYKHDTEAWGILLREAQSQPVDKARPLYELLISSFTNSGRYWKMYIEQEIKSKNYEKVEKLFQRCLMKVLNIDLWKCYLSYVKETKGGLASYREKMAQAYDFALDKMGMDIFSYQIWADYVTYLKGAEAKGSYAENQRITAVRRVYQRGVVNPMVNIEVFWKDYCTYENGINPIIAKKMIDDRSRSYMNARRVAKEYEAVTKGLNRNNPAVPPSGTLDESKQVELWKKYINWEKTNPTRTEDQTLMTKRVMFAYEQCLLCLGHHPDVWYEAALYLENSSKSFAEKGDMNNAKVFSDEAAAIYERAIQTLMKKSMLIYFAYADFEEGRMKYEKVHNIYKRLLAIEDIDPTLVYIQYMKFTRRAEGIKTARGIFKKAREDARVRYHVFIAASLMEYYCSKDQQVAFKIFELGLKKYGDIPEYILSYTDYLSHLNEDNNTRVLFERVLTAGSLPVEKSGEIWLRFEDFESSCGDLTSVVKVERRRLALFKEEFKDRESSLLVDRYRYLDLYPCSSAELKAIGYRDLTQRHTVQVLQNPSISKEAGPSTETKEEEGADAKKTEFPTPDLHQMLPFTPRSQAPPGAHPVPGGVFPLPLAAAHVVSRLPPPACFQGPFVKVDSLMKILAECKIPEPKIENVAINGEMGDNDEDGGGKRKRTGDKNEDSDDDEETHSAPAHDIYRSRQQKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7L0</accession>
    <name>A0A914B7L0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071959.1">
        <property type="nucleotide sequence ID" value="XM_038216031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7L0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216031.1">
        <property type="protein sequence ID" value="XP_038071959.1"/>
        <property type="gene ID" value="LOC119740661"/>
    </dbReference>
    <dbReference type="GeneID" id="119740661"/>
    <dbReference type="OMA" id="QWWKNKH"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="54540" checksum="0E3A1E8DA315B254" modified="2023-02-22" version="1">MDDRYTKTKTCSLASDTDKMGKGGNHTESAVAETQASNLGTIPWDEVSKHNGRAKEDPSKWLVINGQVYDVTAWTKKHPGGSRLLSHYAGQDASEPFTAFHPNMSKVQKYLKGLKVIGKAEQREERREIEEDLKNLRSTAQKMGLFEANYFFYFLMLVQVVFCDLFAYINMLYFGAGWGTFVAAALLTATAQVQAGWFQHDLGHLSVSKSRTVNRALHALLMGVSKGASGNWWNHMHYQHHAKPNVMYKDPDVRLEALFVVGENMPKKMAEKNAAKGKSSMPYNYQHRYFFIIGPPLLFPVYFQFMTFYYCVTRKEWMDLFLSATYYVRFALFYIPLLGFWKTLVLFECMRVLESMWFTWVAQSNHIPMNIEEDQGKPWLALQLSATCNIQQSWFNDWFTGHLNFQIEHHLFPTMPRHNLYRIAPMAKSLCKKHGIDYQLKTLGSAFVDIVTSLEKSGKIWFDAYYSLRHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7W6</accession>
    <name>A0A914B7W6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072268.1">
        <property type="nucleotide sequence ID" value="XM_038216340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216340.1">
        <property type="protein sequence ID" value="XP_038072268.1"/>
        <property type="gene ID" value="LOC119740882"/>
    </dbReference>
    <dbReference type="GeneID" id="119740882"/>
    <dbReference type="OMA" id="DIHIASH"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="756" mass="86695" checksum="5378E47232AD0908" modified="2023-02-22" version="1">MEQEPVMAVQDAENDAVMAAAMGALEEILDRIDCQNALLVSSAAVSNVHLQVPDANQKPPESQCTSEEPNEEAEPQKSNNQKLVSNADDSNPDEALLSVPLPHEGSRWSRLRKQMMGLPDFKEYLKWTEDDSTWSIDEAFASFCLDRVEETLSIAKQTDASTQGKKGTRRKGQPKKYERKQAVPLEDNSKRPARKRRGQDNGLKLTEDDVGLDEDEEDEDLLAMDDNPKDLDYQPLPMIRYPKRRRKSLPRAINNYQAQPKTPSRPKPPAKPTKSPKKTPASKKAAKTPAKTTKLETYSPPRKRGRPRKPATESQKKFPKLKVKAEKPAKTYIRMEVRLQRLPKMYECKTCFEQFPDAEEIKKHFLSVHQRDRLLIPPQNNANENIEGENPNPERSDMDRLLLPDITSLANVLRQCPKCKKYVENMTVHKREHRERNFICEECGKGFTENQILQKHRKVHEMDRTGDRYKCQLCDKSYRFSQNLRSHMLYHGGEKTFICDHCGKSFYTNNRLIIHSAIHMKEKPYKCSECGRGFSQKSNMQKHERVHTGVKPYQCDLCKESFNHKVSLKNHKKKHHGIDWWEEAGRPKPATTRKSKESSQTVVVNTEEPVPIQQEANTVPQEDQLVTENQWKGNDMTIQRDNNVGNQWRDDQQPVREAEPAASPWHQPENNLNLEQQNHAAAEEAVRLQTLHQAGNQWKGNNMPLDRQGQTGEQGMTAFFYPSTYLQGYPSGYPGMPIVPINSDGTVHPATRPSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9N7</accession>
    <name>A0A914B9N7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072710.1">
        <property type="nucleotide sequence ID" value="XM_038216782.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072712.1">
        <property type="nucleotide sequence ID" value="XM_038216784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072713.1">
        <property type="nucleotide sequence ID" value="XM_038216785.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072714.1">
        <property type="nucleotide sequence ID" value="XM_038216786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9N7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216782.1">
        <property type="protein sequence ID" value="XP_038072710.1"/>
        <property type="gene ID" value="LOC119741110"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216784.1">
        <property type="protein sequence ID" value="XP_038072712.1"/>
        <property type="gene ID" value="LOC119741110"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216785.1">
        <property type="protein sequence ID" value="XP_038072713.1"/>
        <property type="gene ID" value="LOC119741110"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216786.1">
        <property type="protein sequence ID" value="XP_038072714.1"/>
        <property type="gene ID" value="LOC119741110"/>
    </dbReference>
    <dbReference type="GeneID" id="119741110"/>
    <dbReference type="OMA" id="KVYTKVC"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275747" description="Fibronectin type III-like domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="648"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="748" mass="82594" checksum="0C07A6BA5A6B7B12" modified="2023-02-22" version="1">MDAKLLYISVLAVLLLHAIPVTRAEFPFRDVSLSWEERLDDLIPRLYLDEIASQMARAGYGPNGPTRPIPRLGIGPYNWVTECLRGDVDSGNATSFAMPIGLAASFSVDLITAVGTATSTEVRAKYNNYTSHGIYKDFGGLSCFSPVINIVRHPLWGRIQETYGEDPFMTGELAKAYVAGLHGPNPRYVRTSSGCKHIFAYDGPEDIPSSRFSFDAVVSEADMQMTYLPMFHECVKAGTFNLVCSYNKINGIPACTNKKYLTDIVRNQWGFKGYISSDASALEYLYTRHKYTQGPLDSAVAAVQAGCSLELSGKRKRVYTHLTQAVELGLVSMEQMTTLVRPLFYTRMRLGEFDPPEMNPYTKLNVDDVVESAAHQELAVSVAVRTFVLLKHTEKVLPVGKIGTVAVVGPMADSPYDPFGDYPPGTSREYITTTREGLKSIASKVKYAGGCNDPRCDKYNQNEVINAVTDVDFVVVCLGTGTSIESEMRDRSNMDLPGSQLRLLQDAVKYAKGRPVVLLLFNAGPLNVTWADESPDVHAIVECWLPAQAAGLAVARFMTNGPEGNPAGRLPFTWPASMDDVPPMTNYSFFNRSYRFFTGTPFYPFGYGLSFTEFNYDRVVVSNPLLKPCDDMHVSVTLTNVGHYDGDEVIQVYIGWPDAVYPVPNLQLGAFLRVKTTPQNQITNYLTIPARVRAVYNEQGETLVVKPGKFYLYAGGQQPGQKRRISSNVLTSAFTVMGSMTKLSDCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9U4</accession>
    <name>A0A914B9U4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072865.1">
        <property type="nucleotide sequence ID" value="XM_038216937.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072866.1">
        <property type="nucleotide sequence ID" value="XM_038216938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9U4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216937.1">
        <property type="protein sequence ID" value="XP_038072865.1"/>
        <property type="gene ID" value="LOC119741206"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216938.1">
        <property type="protein sequence ID" value="XP_038072866.1"/>
        <property type="gene ID" value="LOC119741206"/>
    </dbReference>
    <dbReference type="GeneID" id="119741206"/>
    <dbReference type="OMA" id="HINANFM"/>
    <dbReference type="OrthoDB" id="5966590at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="192" mass="20996" checksum="D16A48A86BD4DAFB" modified="2023-02-22" version="1">MALDEKYFRELADLLGPEWQRLGTELDFDNNKMYRFEVDHHGVSNQIFAMLVAWRQKEGVSELGAREKLLTALRRVDRNDLADKLQARTAVAVPQGAPVDTADAACGGVQITANIINPQETSAQPQSQTSFNYNQPQQAHPTTYTYHAPPGTVPYVGRLTITGRNSPVIIGSVSHSTFNFGGGGGSSGDHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA32</accession>
    <name>A0A914BA32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Thromboxane-A synthase</fullName>
            <ecNumber evidence="7">4.2.1.152</ecNumber>
            <ecNumber evidence="29">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 33">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 34">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="7"/>
    <dbReference type="EC" id="5.3.99.5" evidence="29"/>
    <dbReference type="RefSeq" id="XP_038072956.1">
        <property type="nucleotide sequence ID" value="XM_038217028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217028.1">
        <property type="protein sequence ID" value="XP_038072956.1"/>
        <property type="gene ID" value="LOC119741275"/>
    </dbReference>
    <dbReference type="GeneID" id="119741275"/>
    <dbReference type="OMA" id="HQQNDEW"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 33 34" id="KW-0349">Heme</keyword>
    <keyword evidence="18 33 34" id="KW-0408">Iron</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0456">Lyase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 33 34" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="33">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="460" mass="52368" checksum="F113AFABF330039C" modified="2023-02-22" version="1">MGKGNNLYAEECVIKYGKVVGIYKFQYPILFVSDIDIAKRVLVTDFNKFPNHWDIPAAGFPLNGTLLYMKGRRWKDVRAIITPAFTTSKLRQMVEIFSDCCGPLLDNMGKSHAENKPLNTKKNYLGFFIQTIMAIIYGLDVQCQANLDHPFVTKVEKAFQPSMVTLIPIIFPILGPLFEMMGSNIIPKDAVDFFKQIIEDSFQGGVQIRQRREGAAGYVTMNEMYQKNTEFPGDVPTEEDLAKEAAGKPKKLTYNEFLCANVLLLSGGNEATSTFLLCATYQLALSPEVQDKMIEEIDRLAPTPADITYETMSKMTYLEMVIQECFRMYPPTLLADRVCAETVTYGKYTLKKGLLVNIPFYPIQHDEEIWADPEKFDPERFSPQNKDSVHPLGWIVFGAGPRICIAVKFVMLLAKVFMTRVFQKYRFEACPETPIPLTFGKMTMLEPQNVFVRVMPRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAG8</accession>
    <name>A0A914BAG8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073081.1">
        <property type="nucleotide sequence ID" value="XM_038217153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217153.1">
        <property type="protein sequence ID" value="XP_038073081.1"/>
        <property type="gene ID" value="LOC119741409"/>
    </dbReference>
    <dbReference type="GeneID" id="119741409"/>
    <dbReference type="OMA" id="THIMKMA"/>
    <dbReference type="OrthoDB" id="10066957at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="228" mass="26141" checksum="9A15F4D9B3F7E740" modified="2023-02-22" version="1">MPPKKQSSHEVLTIDPTILSAALVEAFKSKSLIDALVPALTEAITDAVSKNMHEAMQLEFVKRDEKINQLNSKVRHLEHRLDDFEQYSRRNSLLVYGIPEEGQENTDKKIIEAAKQYVNVDIPATAIDRTHRLGAKTDRTGEPRTRPIIVKFNSYNIRAVFYRARAGFKGKNIFVRESLTPERQRWLKQARNHPSSVKAWTQDGRIEVKMKNNAKLIINSENDLKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBA8</accession>
    <name>A0A914BBA8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073498.1">
        <property type="nucleotide sequence ID" value="XM_038217570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217570.1">
        <property type="protein sequence ID" value="XP_038073498.1"/>
        <property type="gene ID" value="LOC119741708"/>
    </dbReference>
    <dbReference type="GeneID" id="119741708"/>
    <dbReference type="OMA" id="PLCSTNE"/>
    <dbReference type="OrthoDB" id="10450245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="28967" checksum="DE5FA6C53AF0F53E" modified="2023-02-22" version="1">MGAIKEFIKEHSPASETPKKKRRVRLKNFNPFRKRKYKVLDENNPDLDECYPRDAKSSLADDQPNSSSEQVNSSGPSTKNKPQKRARPRELLQAAWGSLGLAKGNPNDPDSGKRKTARRQGAYECLVEEETPVDETTTDAAGETVQDLTGSLSESDDEERCDEKGASEVKRVVISDDIKVIETEEQAPPQKKKKKSAKKKIKKAGIKTAKYLGHGFANMALTFQYMTPEAAMAPVAKEIAQRREERYREMCSLAYTLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCG7</accession>
    <name>A0A914BCG7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073739.1">
        <property type="nucleotide sequence ID" value="XM_038217811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217811.1">
        <property type="protein sequence ID" value="XP_038073739.1"/>
        <property type="gene ID" value="LOC119741879"/>
    </dbReference>
    <dbReference type="GeneID" id="119741879"/>
    <dbReference type="OMA" id="HNPGERF"/>
    <dbReference type="OrthoDB" id="5982450at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037608312" evidence="4">
        <location>
            <begin position="23"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="274"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="588"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="89240" checksum="56ABD58C4C8849D4" modified="2023-02-22" version="1">MTSLAWVVETILVMVLCGVVTAQTWRSSSEYVVLDCPNGISVPTDMGRSWARVTWVEPRFIDPDGVEVLPARISHNPGERFPVGSHNIRYSLVDGNHKVTCSFMVRVDDEEPPRIVNCPSDITVPADPGSTSRSSVSWDVPLATDNFRVKHFSSSNPIGSSFSVGYTGVTYTAVDLKGNQAECTFNVIVTDDESPILEGCPVEALTYVPPTANSGPVSWTPPRGIDNAGPPRITCTRSRGESFPLGRTEVMYTATDAAGNSATCTFNAVVKVEIPGNKIFLRNHTSTELEISWPQHVNQKASSYLIYIWPVGASQPQASDHQYHPINWRESFTTHTLRGLSPGTMYNIRIYVTGVGDELDAKLRTKPNAPSDFTFKAESLDSTSVFLMWQPPIGNFDQYQISYQATGSETMTTLRLLDKGIVEKHVTELYPNTSYVFTLVSVSGVRNSKSQSDPATLNATTAPLSKSQILLQKVTATSIQIVARLVPATTTQTPTAYDRGSSQSRLNRHGTGAVRPEVEEDEGDDYHHSNGYVIVIYSNNSDVFTDVIFESGTLQYEFMALVPTTFYTIRIIPSDASGNVQEKTTMTRPSTVTDLVLQEVTNSSVTIAWSPPSGRYERYKVTYAPMKLEDAAPTTVTGNEVTIDGLVPMTTYVVSVVTIYEALTSEPADIQVTPGVDKAEALLTLDEPTCTSPILASCFLAAILVFIGIYICRLKMCYKYMNIHRRHTEENTYENPTRPNSEYLSSPPYQNTEGSETTAMLLRSHPPPISVSGYMYPPIARGLFSRGKRTSSASKGNGSAISPIYYNVKEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD35</accession>
    <name>A0A914BD35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA helicase aquarius</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Intron-binding protein of 160 kDa</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19. Within the spliceosome, interacts with SNRPA1, SF3B1, SF3B3, SF3A1 and SF3A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 19">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038074148.1">
        <property type="nucleotide sequence ID" value="XM_038218220.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218220.1">
        <property type="protein sequence ID" value="XP_038074148.1"/>
        <property type="gene ID" value="LOC119742180"/>
    </dbReference>
    <dbReference type="GeneID" id="119742180"/>
    <dbReference type="CTD" id="9716"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000396">
        <property type="entry name" value="RNA helicase aquarius"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 19" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 19" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="23">
        <location>
            <begin position="24"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="24">
        <location>
            <begin position="494"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="25">
        <location>
            <begin position="708"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="21">
        <location>
            <begin position="799"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="22">
        <location>
            <begin position="1114"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1379"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1428"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1467" mass="168534" checksum="672971C4431E0762" modified="2023-02-22" version="1">MSAAKKGVGRSQAPTVEQINADILTQLASEYWAPHSHLPRRPFNHQVIEDVYQKELIQNRFAIRRVMLLEFSQYLENYLWPNYSPDKAKKNHVISIVVMINEKFREGVPPWEACKAKPEHFAGFFHHVMELCLEEDAAVVSTKEQTIFMGFLIHCFNSLEVDLIREQVQRLVSLPMWVCLLPGRLEKELQAYPKYKKFWNIIKKSDAKADEKTKAKNDIERKFLAGLIQRFYKILDSIPEDGKAQASSVHYCERFVELLTDLEAQLPTRRFLNVVLDDSHVVVRCRLSKLAQRKEGKLFNQLLDMLAFYTGFEISDSTGTALTDHQMTDLHYDNMSSLQRAAFKLFEDLRRFALSNVASVDTRKALSNHFEKLNANQLHQFAAHLHLLPPLPEDTNTVHDKEFLLELMVSRHERRQSQIQVLNETPLYPTEDVLWDENVVPTEYFSGEGCLALPKLNLQMLTLHDYLLRNFNLFRLESMYEIRQDLEDVILRMKPWIAENMETYFGGWARMAQPITALSVVEVAKPNIGETHPASVRADVTVTLNLRQQIKAEWESLRKHDVAFLISVRPTKKIGTRFNLKEEHFIEAVGLLHVRGCEVEGMLNEEGRVIEDGPDPKPELPGAQRTYRVWLDPNQYQQDMAGTAAGGEDVYESFNIIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPGAAHYSKMENQIATLNWNDTFLSLDHLRASFPGYEIKVTTEEPVKQIPPFRITFPVTSGGGKKRKQADSDGTEKRELLVEPHVIPNRGPYPYNQPKRNAIQFTPTQIEAIKAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPSQRTLIVTHSNQALNQLFEKIIALDIDERHLLRLGHGEEALETEKDFSRYGRVNYVLALRLELLKEVERLQASLGVTGDVSYTCETAGHFFLYQVVARWEKFLSKVKPSSGSRAGSAPAIQEHFPFNKYFENAPQPVFKGRTFEEDMDIAEGCYRHIKKIFQQLEEFRAFELLRSGVDRSKYLMIKEAKIIAMTCTHAALKRHDLVNMNFQYDNILMEESAQILEIETFIPLLLQNPEDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRLGVPTVDLDAQGRARPSIATLYNWRYKKLGNLPHVHLTSEFHMTNPGFQFDFQLVNVENFNGIGESEPNPYFYQNLAEAEYVVAVFMYMRLLGYPAEKISILTTYNGQKHLIRDVINQRCASNPLIGQPSKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYVFARVSLFQNCYELSPTFNLLLERPLQLHLHVSQSETYPSTKKVEEPRYDSPLVIEDMPHMAQFVYDFYQDKIRRLQASRGHQRQMQAELAKPPVSREPRPAKPAGCEQPKPPGMPADVQAVGEASKPQEEEAMEEGKSDEATKEKTEERPGGGEDQKMEDVKTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDB1</accession>
    <name>A0A914BDB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">V(D)J recombination-activating protein 1 RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073986.1">
        <property type="nucleotide sequence ID" value="XM_038218058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218058.1">
        <property type="protein sequence ID" value="XP_038073986.1"/>
        <property type="gene ID" value="LOC119742038"/>
    </dbReference>
    <dbReference type="GeneID" id="119742038"/>
    <dbReference type="OrthoDB" id="8193306at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033151">
        <property type="term" value="P:V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058554">
        <property type="entry name" value="RAG1_RNase_H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26100">
        <property type="entry name" value="RAG1_RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V(D)J recombination-activating protein 1 RNase H" evidence="2">
        <location>
            <begin position="214"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="408" mass="45344" checksum="8D5F35D930DDF9CB" modified="2023-02-22" version="1">MLDEPFLKVTPKDKAKLMVDTSSLTVVEALNLSSVSSLGSPDNRRDQETQCDCPNLAPLDEVGPRQQFRRTNSLLHDLREEAEENGISATELMGYLLHKENYISNRKTADVGLKLFNKSLVDKEMSVDKGLYILSSYNIGRTGYTNLRRDLNEHVTLPAHYKLMEKKNSITPELKPYSIDDNEGITASLKESCSIHVKRLIEAHPEIQPGQYRVLCKDGLDGSGRHSIYHQKGPAQTYSMILYMWILLEVIKEAGSSGESSSGEGSSQASGLTVWKESAANSPEAAVPLFLVKGKEDRELLKSIIPPIEAEKTALSTTGIEINISGASYHFRFEFNLTMVDGKMVKLLTGRGGAYCILCPASRDECHNLDRIDEGFPIGEVSNEDLRKLYQDLQDEGEIKPKPGDYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BER7</accession>
    <name>A0A914BER7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alanine--glyoxylate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2-aminoethyl)phosphonate + pyruvate = phosphonoacetaldehyde + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:17021"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57418"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="2.6.1.37"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038074738.1">
        <property type="nucleotide sequence ID" value="XM_038218810.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074739.1">
        <property type="nucleotide sequence ID" value="XM_038218811.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074740.1">
        <property type="nucleotide sequence ID" value="XM_038218812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BER7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218810.1">
        <property type="protein sequence ID" value="XP_038074738.1"/>
        <property type="gene ID" value="LOC119742660"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218811.1">
        <property type="protein sequence ID" value="XP_038074739.1"/>
        <property type="gene ID" value="LOC119742660"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218812.1">
        <property type="protein sequence ID" value="XP_038074740.1"/>
        <property type="gene ID" value="LOC119742660"/>
    </dbReference>
    <dbReference type="GeneID" id="119742660"/>
    <dbReference type="OMA" id="IHCETST"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010006">
        <property type="entry name" value="PRK13479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02326">
        <property type="entry name" value="transamin_PhnW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42778">
        <property type="entry name" value="2-AMINOETHYLPHOSPHONATE--PYRUVATE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42778:SF1">
        <property type="entry name" value="2-AMINOETHYLPHOSPHONATE--PYRUVATE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="29"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="374" mass="41816" checksum="C9BEB4BA38B4A3D8" modified="2023-02-22" version="1">MREKKLFTPGPLGVSLSTKQAMLVDLGSRDLEFIQTVKSIRSRLVELAGVSSDDYTCVPVQGSGTFAIEAVFTSTIPRTNGKVLVLENGAYGRRFGQILKVLGVDFKILTFLENEKVDVGLVEETLRGTQGWTNVAVVHCETSSGVINPIGEIGRLVKECVPDASYFVDAMSSFGAVDIDFTASKIDFLVSSANKCLEGVPGFSYAICRKDKLTGCKGWSRSLSLDLVSQWETLEQTGQFRFTPPTHCMLAFKQALTELEEEGGISERRKRYKENNRIICEGMKAFGFKTLLDDTHDGFIITSFHYPQHDNFNFKDFYTRLQEKDQVIYPGKVTKTDCFRIGNIGHVFPRDMRYLLQCVQEVCSDMGIPLPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGE8</accession>
    <name>A0A914BGE8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075333.1">
        <property type="nucleotide sequence ID" value="XM_038219405.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219405.1">
        <property type="protein sequence ID" value="XP_038075333.1"/>
        <property type="gene ID" value="LOC119743062"/>
    </dbReference>
    <dbReference type="GeneID" id="119743062"/>
    <dbReference type="OMA" id="KSHIMSH"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001111">
        <property type="entry name" value="Zinc finger protein 92 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="800"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="910"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1346" mass="153317" checksum="7187B7C379783D3D" modified="2023-02-22" version="1">MSVMDGSSGASPPDLEGGFNTVAINEEIVDELVEANTKSSVPDQLLNRDIDSECLSDDGLLSLSAADSSAAFGSVPETTHDNVGSSLVQNSSDIAMDPTMSLLRDDIQDAIGSSPVENLSSLGLESKQTGVDVVPVVNNTDQSESCQLQSVVGQCSLDNADLSEIPPIQSSGDAEVCRSVEGQPGNEVTEMLVESPSSQRSTCQDEPSLKCLECDLTFANGISLKAHQLTHKAESQFVCGICCKGFSSESLLSSHFATHSDSRRYTCPHCGRIFRNLQSFQQHEKLHKAGQMFTCKHCGKAFRRQSILQKHRYSHLKKIRIEYSCEHCSECFATVLQLQQHERKVHRGRGKGKPERTYKCEECFESFCNEDLLREHQQQHVMQRENYCKDCGRDYNSPDALKNHRCFRTRKALFTCKDCGRGFAKKQDALDHERTHRETEREFDCEICFETFSSKAELREHTAVHRNTPSFKCRHCDKQFKKKGFLTNHEKTHTQHRQSRRGKSKSTQPDAVSNHVREDQRKSDLRHESVFVRKEGLYRCQDCGKTFRQKGQTIYHQKKETNSRAYPCTKCSNSYLTSAHLKAHMLTHSTTRTLKCDGCGREFNYKSNLTCHQKKCPQITGVEDNIRKSSRRYNNQAKASTVEGGESSLDEEREEIDNEIDSPNGIEQGQVQHQCIYNKDIRLYQCQDCGKTFKQKGQTLYHQKKVSNARQFVCKVCKKAFLTSPHLKAHELVHISEKPLSCEGCGKGFNYKCNLKTHQRNGCLGVDPESKLALSTMKLYKCEECGKEFKLKMYYEKHQKMHERRNQQQEAETDGDVDIDQIGQRKEHRSDYNEEEGTYKCRDCHVVFKQSGQALYHFRKYSNERKFVCKVCPKSFLTSAHLKSHIMSHTKEKPYKCWYCGKGFNHNSNRKYHQRTSCSERPPPGEQMEGDAHSENSRGRGEAKKPITCVVCNKQFMLTHSWKVHMRVHTREQPFLCEYCGKAFRCRSNLYVHRNSHTKERPYLCNYCGKNFAQLSHVKVHEAIHNTEKPYKCGICGKSFSQEFYLKRHKVMHADDRPFVCFCGKSFKYRGSLVSHKATHSSKRPYGCHLCSKAFKQSCHLKVHILTHGELKPFKCDKCQKAFIRKNQLSRHQRSHSDERCYRCNLCGKDFKHSSSMKRHQERKHNKEPSDTAGSTTTTTTTTAAAEPQPVFDSVPYSQPQTNVKKNGFRVNNPKTSWPAAVDGVSIEQDTQMQMTTAQLDAGPQPNQHVDNRVLTQMDNRLTGQPVECRMAGQPIDYRVSPQLTDPRLPPESSVPGHLSHLASGHPVYSEAQYIQGAEFASVHLPHIGTFDFRTSTSGSVDYTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJX0</accession>
    <name>A0A914BJX0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075742.1">
        <property type="nucleotide sequence ID" value="XM_038219814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219814.1">
        <property type="protein sequence ID" value="XP_038075742.1"/>
        <property type="gene ID" value="LOC119743419"/>
    </dbReference>
    <dbReference type="GeneID" id="119743419"/>
    <dbReference type="OMA" id="TNINIYY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF72">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37936" checksum="F494994725166DB9" modified="2023-02-22" version="1">MADYESDKTGLATNETSGIWTKFSLVLGISTVGLLFFRRYFHGAKCRSLAQLTGKTVIVTGANTGIGKATALDLARRHARVILACRDVQKAKQAADDIQRSTHSQQLVVKHLDLASLKSINKFCDDILKTEPQLDILINNAGVSWLPKLTRTEEGLETQMGVNHFGHFLLTNRLLGLLKKSSPGARIAIVSSSLHKKGKIDFANLNAERGYNQFQAYYDSKLANVLFGQELHRRLESEKAGVSVYTLHPGVINTELNRHTMHPLLLKFFLRPLFWLFMKTPTQGAQTTIYCAVAGELEGLSGRYYGNCKEEPFPAVASRADESIAKKLWEVSERLTGLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLD4</accession>
    <name>A0A914BLD4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076914.1">
        <property type="nucleotide sequence ID" value="XM_038220986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLD4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220986.1">
        <property type="protein sequence ID" value="XP_038076914.1"/>
        <property type="gene ID" value="LOC119744827"/>
    </dbReference>
    <dbReference type="GeneID" id="119744827"/>
    <dbReference type="CTD" id="23194"/>
    <dbReference type="OMA" id="ETVHVDR"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF50">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="500" mass="55648" checksum="40C70895401815B4" modified="2023-02-22" version="1">MGAQNGKAYDSATDRRTGSSFSQSDLSADDYNFSSSAQSPSYTNSSADSLQVVRKLRLENGSQASPKSPSQESKSTATSSGASSSATSPTPLIETQEVTEVDMTKMRKKLAPPRTANDSPFDKLTDKVITNIFSYLTAKRLCRCSQVCKRWQRLAWQPCLWTSILLSKRQKNIDYALKCLIRRLCLETPYVCLTVERIVLNGCDQLTDRGLSLIARHCPELLRIELGGCNNITNEGVFELVSRCPSIDYMDLMGCQQVNFLNFPSDYNASRASPLQGQTILLRHLDLSDCSSLDDSGLRIIATNCPGLLNLYLRRCYQLTDIGVQYLSAHCFMIKELSLSDCHRITDCGMREVAKLESHLRYLSIAKCELITDMGVYAIAKLCVKLRYLNVRGCAHITDKSLDVLARGCPRLRSVDVGKCPSITDRGVASVAVNCSGLRKLSIRGCVNVTSESLTILARYCPELQQLNIQECDELSVQAYRVLKKHCRKCIIEHTNPAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM59</accession>
    <name>A0A914BM59_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077020.1">
        <property type="nucleotide sequence ID" value="XM_038221092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM59"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221092.1">
        <property type="protein sequence ID" value="XP_038077020.1"/>
        <property type="gene ID" value="LOC119744897"/>
    </dbReference>
    <dbReference type="GeneID" id="119744897"/>
    <dbReference type="OMA" id="WALNPDC"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF206">
        <property type="entry name" value="FORKHEAD BOX PROTEIN Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="429" mass="47205" checksum="727A6123AD0C9210" modified="2023-02-22" version="1">MARSSPPNDCDTLRSTAPVKTKSRRPNYRRRVKLPHTFAELITMAIKESETGKLTLKEIQSHMSASHDCFRGAYSGWKNSVRHNLSTCSCFVKVLKNKAQPNGKDNYWALNPDCPHCVMLKSRHSFHQSAGASTGTGRSSSEVSASNPPDTKTATRNLHKSSSPPTTQNVATTAAHTSSNPTTPLTAQPTPLHSINRDFLVGRAGVPVNQPESSQGHQLSSKPQPTVSTASLPTNEWNLPMSGLYNPDGEIDLSLYGDDAWPSSESRQSFHTSTGHFHQEHQRDIKPKALSTWMGSGIYPPYHSLSTEGALPRTAPYPQPAKIRIKSEYVAASSHRYHPYHAAQTFGSFRDRRVDYSCYSVSRSEPGHHYGPRWADDSRTVPNSSQGDSVVVSAIRSSLGLDLDEMALYAIEHSVRVLDVTRPCDLMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRW8</accession>
    <name>A0A914BRW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat, SAM and U-box domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079047.1">
        <property type="nucleotide sequence ID" value="XM_038223119.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079048.1">
        <property type="nucleotide sequence ID" value="XM_038223120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223119.1">
        <property type="protein sequence ID" value="XP_038079047.1"/>
        <property type="gene ID" value="LOC119746275"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223120.1">
        <property type="protein sequence ID" value="XP_038079048.1"/>
        <property type="gene ID" value="LOC119746275"/>
    </dbReference>
    <dbReference type="GeneID" id="119746275"/>
    <dbReference type="CTD" id="151525"/>
    <dbReference type="OMA" id="YSEKAHD"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="367"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="441"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="510" mass="55748" checksum="9C6CC7BCE035D4CE" modified="2023-02-22" version="1">MQSQRSHTANLMATATLIHTLKSHSSDVNCCCFSATTVASCSGDKSVRLWSLADFKELPISPLLGHTYYVHWCVFSPFGTILASCSTDGKIILWDSRTGESQAVLQHPSKAIVRVCVFSPNSEMLLTGAADSSLCLWNVQNKTLIRTFDGHENVITACAFTPDSSFVVSACASGDLRIWDALYGQKKSLFFDPECHDLGVSCSVISPTFGSADPNAEINNDRRSYLLATCGGENLVKLWDLIVFPACKTKLRCSMTGHTAKVMAVAFSPDGGLLASGAVDKIVIVWNPIEGSMLYTLEDHSRYVTTVAFSPDGRYLASGSNDRTVKVWLLHAEGEAPNLSLPSGSQQVTGTLQGAESAPPKNLLLEWSIDDVCDWLKAQGLEEYVQSFHDNQIDGQELQSLNTDTLVNDLGVKALGHRQKILRGVQVVREKGSSGQILDDGIPDEYLCPITRELMKDPVIAADGFSYERSSIESWVRSNKTSPMTNSPLVHSNLTPNRSLKMIIQRLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS91</accession>
    <name>A0A914BS91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078486.1">
        <property type="nucleotide sequence ID" value="XM_038222558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222558.1">
        <property type="protein sequence ID" value="XP_038078486.1"/>
        <property type="gene ID" value="LOC119745892"/>
    </dbReference>
    <dbReference type="GeneID" id="119745892"/>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="747" mass="85533" checksum="3F91A73B6412FBF2" modified="2023-02-22" version="1">MATKSRKSITIALALTLASVVVYVCCYGADMSPTKYPISNIETPKRHNEKAFHIVIIGSGPTALGAAQRLHELRQQYSNTKVTILEQQDKPGGLASSERDEKGFLWDMGGHVVFSHYDYFDKTLDRAVAEWNQRVRAAYAFMMGSDGERRFISYPVQNNIEVMDKVDQQKCLAGLEEITSNPSKEKPANFDQWLLHNFGIGLCEVFMRKYNKKVWTVETNQMNAVWVGERVAVPDVNKLKAKIQAYDNGRRVEDSGWGPNRFFRFPKYNGTGAIWQGVANLLPQEWFQFRTRVTGVDLDSQQLFLVKGGDEYTTHALSYDKLISTEPLDIFVNMLVCKDDYLSQMKELVSGLVYSHTHVIGIGLLGQPPKTLSDKSWMYFPDSDSPFYRVTVFSNYSDDHVPKAGAYWSLMCEAAEPKEATNPKDWTEKNVVAATVKALITYGFITDEMVVSKYYRRLDHGYPVPHLKRESILNIVQPWLSAHSIYSRGRFGGWRYEVANQDHSFMQGVEIVDQILRGIPEETYPHPNFVNSRKNTGRFLNQPLEYEFVIAHYNEELDWLKPIANRSHVYHKGPDMQPPFAVSKWETLPNLGRESHTYLHHIIENYDNLKNITVFLQGHGPQSDGGFCFPQPMDFVTNALKKRFCRARGATEDWNGLHYTGNMPQDIKSGVLRKSNTTLSDVYAALFNASHPPSLPRCLKGCFSGTRDNIWKHPKSFYQKAMRYVDFHPNPEEGHFMERLWCVIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSY6</accession>
    <name>A0A914BSY6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078716.1">
        <property type="nucleotide sequence ID" value="XM_038222788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222788.1">
        <property type="protein sequence ID" value="XP_038078716.1"/>
        <property type="gene ID" value="LOC119746032"/>
    </dbReference>
    <dbReference type="GeneID" id="119746032"/>
    <dbReference type="OMA" id="CGMFTAF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="182" mass="21066" checksum="5D975B5ED4DA2C8B" modified="2023-02-22" version="1">MKIKMAASMFVVFLAVFVLHLSRYFIPSIVKQVTKILFQDSQVEGSLKIKIKKLGDEQSELNVKEEFPKFARIDRKINKLKDELKKIRQSKTAKSFTVSWGLTLALNSVQTCCFIFLIWRYRHEPMLILNEEWLWPLSWFIAFPSAVPGAVGITCWILLCNNILKRGQVMITAAWAPENQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTJ6</accession>
    <name>A0A914BTJ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079360.1">
        <property type="nucleotide sequence ID" value="XM_038223432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223432.1">
        <property type="protein sequence ID" value="XP_038079360.1"/>
        <property type="gene ID" value="LOC119746470"/>
    </dbReference>
    <dbReference type="GeneID" id="119746470"/>
    <dbReference type="OMA" id="HKTNRSE"/>
    <dbReference type="OrthoDB" id="10448421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="41233" checksum="1ED7210F4617AEBF" modified="2023-02-22" version="1">MSVQTASSKPKERRLSVNVAMAVVHKTNRSEDKKLERRVEHLKQKEHQDQVRHCSEVKKLEKELESMQMQVESAPRTFTKREIEEKDVPYLFGKKMTAQQPRAIRRRRHRGDSAEAALNRVVKNVEITGKNRFRSAVMAVCVAKGLGGGDSEDGVVVPDQEGETEPILSGEELVVSGGQSRCSLSARSGLQRGRVRIQTYPSERPYTSPVKTASQRRSSTLPPPSTTRDSQSQPKPASARSINSRRSTIGSLSFRSDSPPPSVGLPVSLPDLVGAARASIVHAAESAKAATVLKRRGSAVNTVTAAERDLERRRSSAALRLQGIKQDLSRRDSDLQDRIKLFVKTSMPGESSARSPRRLFAIPVGGEPPSTDMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTJ9</accession>
    <name>A0A914BTJ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079365.1">
        <property type="nucleotide sequence ID" value="XM_038223437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223437.1">
        <property type="protein sequence ID" value="XP_038079365.1"/>
        <property type="gene ID" value="LOC119746474"/>
    </dbReference>
    <dbReference type="GeneID" id="119746474"/>
    <dbReference type="OMA" id="EINLFHG"/>
    <dbReference type="OrthoDB" id="10442548at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="16824" checksum="E21F68DF1D365484" modified="2023-02-22" version="1">MTSSRVLVENSPFHLVPCSPYIGTTISTKSPAVRAVPEVAETAVPSVADSPRSTAGQDVPQTPVSHHISGLSNQQNQRIISPAHNAHRAATPEQEVPKTPTPTDSSERKKRSTLILKIKTSTITPPARRDDAKEINLFHGDDDDIFHGDNDDIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YX88</accession>
    <name>A0A913YX88_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044369.1">
        <property type="nucleotide sequence ID" value="XM_038188441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YX88"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188441.1">
        <property type="protein sequence ID" value="XP_038044369.1"/>
        <property type="gene ID" value="LOC119719123"/>
    </dbReference>
    <dbReference type="GeneID" id="119719123"/>
    <dbReference type="OMA" id="PEDTTIC"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="570" mass="63865" checksum="6A78FCB088C851E5" modified="2023-02-22" version="1">MDVDASLRVVGLVGRVQIANFVIFGMGLSLSAIQLTGIAFTVDQSVAHHCKPAPGSLANETMVYVEKDGREVPDGCYMYDVDNGTFPEDTTICKYGWEYAPEYGEKSATTDFDLVCDRGYLANLLMSCHFAGFLVGGFITGQAADMFGRRVVSMATLLLMSVLGTAISFTWNLKLLMALRFILGVVIPGNSLVGYIRAVEMFTPKKRLLGHVFIQHFWSFGVILVAPLAYLFPNWRYFQLFTSLICLPVHVIMWFFTYESLRWLVQKGWFEKADAILRKIAKSKNIKHNGSFLIQRELEAVRLVGKMELSEKSNHDRASDLQHESVTADVEENNQEPMNKEKMESFTQPDENGQTQSKKKKKYTVLDLFKTKVLIKHTCIVFCLWYVMNTTYNGFIVYATSLAGNKYLNFFLLALAETPAYSTDFFIVRRFGRKRPLIVFFFTGAVACLLIAFLPSKTANGTDFTVIIVIVAMIGKFYANATYEVTMLMGAEIFPTMLRNIATGSASTVGGISGIIAPFIVYLQEVRSFLPMLVIGCMSLVACSLVFMLPETKNKPLPETYEDASKLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY75</accession>
    <name>A0A913YY75_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044317.1">
        <property type="nucleotide sequence ID" value="XM_038188389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YY75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188389.1">
        <property type="protein sequence ID" value="XP_038044317.1"/>
        <property type="gene ID" value="LOC119719081"/>
    </dbReference>
    <dbReference type="GeneID" id="119719081"/>
    <dbReference type="OMA" id="QADAPFE"/>
    <dbReference type="OrthoDB" id="5948587at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13751">
        <property type="entry name" value="TGF_beta_GDF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF262">
        <property type="entry name" value="LD29161P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999975" description="TGF-beta family profile domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="330"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="49981" checksum="B96F40C7767D739F" modified="2023-02-22" version="1">MKHLQVVLPVALTLQLFFLACLARQLPSSKQYNPADNGHLRGGKPLRGPSSESGPDTGGDIVTEDHSSGQTPTTTSTDTAVLNRTASPARERAARCGACEMRDHQKALRIESIKEQILRKLNLKSVPNITMPLPKIPPLQQLMGGQDSDMSAMQGDAPGHEQFRMPHMNDYDSTPHYGATTKRIFTFAKPTPPELHLEDPTICFFDVQDKTDGYVVSKATLYFYVQPAKLLQTTVHLMSVSRVVMMKGGRGMIKLDTVREEKIVLSSRHGEWQSVELTDVVTEWIDSPGTNNGLKIELYDDGGNSVVVTGLTDDEETKKPFLQLRLHDARRRRSRRAAGLICMENQPAERCCRYPLRVVFADFQWDWILMPKAYEANYCSGLCPRMRLQQYTHTKIMSMVNPPPEGYMGPCCSASDMSPLTVLYFDDNADIKYSLLTNMVVESCSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYA2</accession>
    <name>A0A913YYA2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044538.1">
        <property type="nucleotide sequence ID" value="XM_038188610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188610.1">
        <property type="protein sequence ID" value="XP_038044538.1"/>
        <property type="gene ID" value="LOC119719235"/>
    </dbReference>
    <dbReference type="GeneID" id="119719235"/>
    <dbReference type="OMA" id="MSHEDMT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="215" mass="23230" checksum="3DEF7B109F6C6867" modified="2023-02-22" version="1">MAGHYDLDDNVVPDLQCYEMLPADAELQIAQAFAGNEPTGAFKPKSPVHHASLSALPVALHGPSGCLDENLLQVPYLASDGLVGSSSEPDGLEGAVFDSPPDIQTVPSLQDTPRGTAISASSHSMARFDHQSVSSSDDSTSRCVTATSTAVSHSPYEVPDMYANLLGLLMQHREQHVKWSPPARFDDRNCGRSDLQFDGRCDCDVHLVPRWDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYG9</accession>
    <name>A0A913YYG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transcriptional repressor NF-X1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044789.1">
        <property type="nucleotide sequence ID" value="XM_038188861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188861.1">
        <property type="protein sequence ID" value="XP_038044789.1"/>
        <property type="gene ID" value="LOC119719422"/>
    </dbReference>
    <dbReference type="GeneID" id="119719422"/>
    <dbReference type="OMA" id="CPHPCDS"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02643">
        <property type="entry name" value="R3H_NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16696">
        <property type="entry name" value="RING-CH-C4HC3_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034076">
        <property type="entry name" value="R3H_NF-X1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="14">
        <location>
            <begin position="878"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113551" checksum="13B0F7D3DE90BDA0" modified="2023-02-22" version="1">MAESNLRETAPEFQPTQSQSYAPQYQYTGQQNFQPYQPYLVTQNYVSSEPAYRPRGSRSRPFSRRERGRYAPNFNQNFGAGHFQPPPFQPPLAEYSNFNHNQPHMPEFFEARGQRGVAGVYRGRGLRSQRAPFRGQIHQMQQPYFHSGAPSYQGDEPRDQSSGRSSDTRWRYDNPSVESRNADKRPNSGRGRSKNSAAKQSYRNDVAKVRNRPKYEGSTETQTGSMIEQLTEGAYECTVCCETVRCEAPIWNCQECYTVFHLKCIKKWAKSPAAAAEDSDGWQCPMCRNVTLLIPYGYKCFCGKQRDPPYHRGEMPHSCGEVCRRARAKTNCVHTCNILCHPGPCPPCPASIKQSCLCKKTSQTVRCGTQQVIRCQAECGKKLNCGVHSCDAVCHEGDCKPCEVEMKQECYCGKDSKVVLCSLGDDGNLLQEGPAQYPCQAVCDRTLSCGNHTCKRPCHPGPCDLCPLTPDLVTRCPCSQTKLSELTTHGEVRKTCLDPVPTCKNTCGKPLKCGGDYVHTCKQPCHEGDCPVCPLNSTVRCRCGHRMIDVLCRELVKAYDPLTGQVSMMCDRKCPKKKDCGKHKCNVKCCVAKEHNCNQVCGRMLNCGLHRCEEMCHAGNCVRCLNASFDEFSCHCGASVMMPPIRCGTKPPECSEPCARRHDCEHPVRHTCHSEEVCPPCADLTSKMCMGNHEKRHNIPCHIKDISCGHPCGKKVPCGMHICKMICHKGSCEACKQPCLVPRPECGHACSAPCHAGSPCPPSQCKTRFVIRCACGNRSETIQCLQGGDDVRLTEAFQRLATSTVAGQGSQSGQDVDISQLMALRNSKTQRQLECDQHCSILSRNKRLASALQIKDPDSAKFSPTYNPFLKEQARKNPQLIANIIKELSALVTSAQSSKQPSRSHAFPAMNQIHRRVVHELSEMYGCESQSYDQEPKRNVVTTARKGTCFIPTVSLSTVIDRETHPKAPPPIVHTKHETPRRLTSLSKMPRPESPTSPPPQPKEPIVDNSEVPDSWEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYP0</accession>
    <name>A0A913YYP0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044683.1">
        <property type="nucleotide sequence ID" value="XM_038188755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYP0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188755.1">
        <property type="protein sequence ID" value="XP_038044683.1"/>
        <property type="gene ID" value="LOC119719310"/>
    </dbReference>
    <dbReference type="GeneID" id="119719310"/>
    <dbReference type="OMA" id="NTHENHT"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="57966" checksum="AB1C709B92DF1B10" modified="2023-02-22" version="1">MDTLQSEEKLIGLPEELKAYIFGHLTATDLCHVALCNRILRESANQDALWRLLCRKNGWERYGTNLCKEPPFTPTLHDQLTGGEGGSPTFPVDAVVTGSDWPGLVDTCKWKEVYMKARHLEENWRNQRFYATTFKFGQTSDETGLFAVETLDQPKISNLDCEGGCLAVGVDDGTLQIWDVSIGKRRHNIRVNVSEEPDALKMKDGIIAAGCMDGKIRTYSAQTGEQLQVMSGHYLAVSRLFFDGDTIVSVARRLLDRSKNYADSGIRVCKAEDASTRFVLQYGCSKTSLIHLDYRTKVIAGAYSDNTIQIWDAENGSDIQHIICDMKKLVSCYLGDGIVIGASKDFAVKIWKLESWECLRTFRVPLHPESNNFELIGAAPYAFNGELLVAISRAHLTFMDLEGKLIGSIFNTHENHTGTFFTQDNSKFTTAHCFHGNKLITGSSNTYSGKYDLWIVNPAMGVYGSGEVVSKMDLGGEAFAEFTGAFSPAWMNDTKVVFEGIDKESGFGPQRPTIVIRHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5I5</accession>
    <name>A0A913Z5I5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046040.1">
        <property type="nucleotide sequence ID" value="XM_038190112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5I5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190112.1">
        <property type="protein sequence ID" value="XP_038046040.1"/>
        <property type="gene ID" value="LOC119720448"/>
    </dbReference>
    <dbReference type="GeneID" id="119720448"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="19530" checksum="594BAE9F79502CFC" modified="2023-02-22" version="1">MQSVGINILFFPFSCQASYTGERCETDVQEPDGGSLSTVTVVLIIAGCTVLLIVVVCMLVCMCLLIQRQHAKSLVYREDRQRSGVRRESRSIFDNYGDRSTESVDVSCMADFDDEAVRMRRLMHVMGRSRYLQGNLSAREEFVLPYMATGIEGLYREDGSVNPAGRVVRNPMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8K5</accession>
    <name>A0A913Z8K5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047190.1">
        <property type="nucleotide sequence ID" value="XM_038191262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191262.1">
        <property type="protein sequence ID" value="XP_038047190.1"/>
        <property type="gene ID" value="LOC119721272"/>
    </dbReference>
    <dbReference type="GeneID" id="119721272"/>
    <dbReference type="CTD" id="51322"/>
    <dbReference type="OMA" id="FEPADDW"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="692" mass="76297" checksum="5D9FB14D10D98F0C" modified="2023-02-22" version="1">MVMHASKHPRLSDGFHDRNEAHPFQTVDRYPAKGHSGKSDSNQGSMSSRPTDHTDHADHRDRLQLANKDSPNQRPTTSPASRQSNDRSSPRTYRSKESYLQRQREKQKSLGSSPAENAVNHHGTNSHVTDHERHIKTILAKAGEWTEHTSSSGKKYYYNCRTEVSQWEKPKEWMEREKLQRALGSKERPVAKESPRPAQSGDATPSKSDANNKHSIESSHEKPTPSPHQHQATNRYPDRPSGRPQDRPQSKPQERPVLRPQDRPATTSAATLSRAYSSNSTQSQKRPSQSNQTPYSSLSRSQNEGVRTERDRRHEMDYPHHREHSNVNDKARSGSSASSGGNSSSAGGGLSLATDIYGRLKPLVSYSKTDRDRTESPRVRTTPSPGTPTATPSPHLSKPHHNNQLNQQSLHPPVAQKLFPAHSPSLDRHGHPHHHSDRVDEAFERLSNHSPVSVASVSDLSSPAVSQPSPRNQASTTPLLAQPQPSSHPSQSRCNSQSQSRSCNAQSQPGPQPDSRSATPTSVAHPPVKLSGVSSADVKQEQPTPELDAEEPVVENEATVDSKQLSPISTSPTPSQTSSQSGTGVASLPTTPQKPAVATLTPSLALCYTESLTKHVTGWSSELMDRQAQRLFEESHTLGAELCAKVSADLKFARSLVRVSEIQATLQEQRILFLRQQAKDLEKLRNENAYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9P9</accession>
    <name>A0A913Z9P9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047610.1">
        <property type="nucleotide sequence ID" value="XM_038191682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191682.1">
        <property type="protein sequence ID" value="XP_038047610.1"/>
        <property type="gene ID" value="LOC119721601"/>
    </dbReference>
    <dbReference type="GeneID" id="119721601"/>
    <dbReference type="OMA" id="TILEWEW"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000003">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15741" checksum="927757EE9849D292" modified="2023-02-22" version="1">MKVAPHCPMYGEVVVGEVTDTPGVGDLSQFKRNPFVVKEGAKYRIKLIFRVQREGVSGLRYFEAVYRKGIRVDKANFMVGSYRPKTEEHIFQSPVDELPAGLLGRGDYIVKSKFTDDDKNIYLEWEWSFSVKRDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9T8</accession>
    <name>A0A913Z9T8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048394.1">
        <property type="nucleotide sequence ID" value="XM_038192466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9T8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192466.1">
        <property type="protein sequence ID" value="XP_038048394.1"/>
        <property type="gene ID" value="LOC119722387"/>
    </dbReference>
    <dbReference type="GeneID" id="119722387"/>
    <dbReference type="OMA" id="PAYEMEI"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="496" mass="53234" checksum="6B357B43C83D4B4F" modified="2023-02-22" version="1">MLSQTRWRLLIVCAVFMQVLIAVGPLYSYSVFLVPLQTEFQSSAVLTGWVGSLGSALLCCISPLVAVIAWKIGTARVVFLGTILTAAGYLATSFISSLAQGYLTFSLMAGIGAGFMNCGSVNLLLEWFIGQSNACRSTAAASTGTSVGVMVFGPLLNTLTASYGWRNCFRILSGIMLTLGLLTALPFLKPPEKRKGQQADETDVKVETPPRDKAEQSGESHEDPRQGVTDLKTCGGLDSEDPDRKKRSRMKFFCEMVLNVEVWLWVSAITMAQLGWSFVIINYTSFLEGLELSTENISLALTVSGAAEVSGKIVIAIIGDRLPFLKLYVSVVALIVAAMVSGFLTLCSTFWSIIVMSIVWGYCRGTIFGVAMAAALELFKMYGPGAVAAICLLGFGTGVLIGSPITGVFYDQTGSYTLSLFAVVASFGLSTLCTVLIPIKRKFATRCCRKASENTENNSADEAKVDPAVPIVETRSVGISNPAYEIEMYSVKSNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA84</accession>
    <name>A0A913ZA84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048539.1">
        <property type="nucleotide sequence ID" value="XM_038192611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192611.1">
        <property type="protein sequence ID" value="XP_038048539.1"/>
        <property type="gene ID" value="LOC119722476"/>
    </dbReference>
    <dbReference type="GeneID" id="119722476"/>
    <dbReference type="OMA" id="KEMEDHY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27939" checksum="2CF91EE3A8570C78" modified="2023-02-22" version="1">MARIKPHPNVVGLMGACMHEAILYVALEYLPNGNLRDYLRSTRPKQQGAMKSDDGVSPLTSSNLLTFAIDIASGMDHLSDTGIIHRDLAARNILLGEDLTAKISDFGLSRGEDIYVQKSQTRVPFRWLAIESLTRRVYKSKSDVWSFGIVLWEIATFGATPYPGIQRLLLAKRLQEGYRMPKPENCADEIYDLMMKCWQPHPSHRPSFKEIMATLEKMNDPSDENIYMTTRFYVNHVIKPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBA4</accession>
    <name>A0A913ZBA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038048175.1">
        <property type="nucleotide sequence ID" value="XM_038192247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192247.1">
        <property type="protein sequence ID" value="XP_038048175.1"/>
        <property type="gene ID" value="LOC119722201"/>
    </dbReference>
    <dbReference type="GeneID" id="119722201"/>
    <dbReference type="OMA" id="FFITHIF"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="35586" checksum="1B8BB645F1742110" modified="2023-02-22" version="1">MERYETPDLRVTLYENGTSIRDIANEKVKDNEPKREDVDDPFYLYDLGDVVTKDKLWAKLLPNVEVFFAVKSNPDPVIIRLLIGLGKSFDCASKKEIKMVLDLGASADRIIFAHPYKQESHLRFAKEKGVRLMTFDTAEELQKVKRVHPKAQLVLRIRYDDSTATFNYGAKFGCRGEEVRPLLEIAKKLGLDVVGISFHVGSEASNPQIFSDAIRFTRPLFDIGTSLGFNMKLLDLGGGFPGRLYPKATFDKFADVITRALDEHFPASSGVRIIAEPGTFYTRSAGYLVANVIAKRVNKVDINERRERVSVLFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZC53</accession>
    <name>A0A913ZC53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histamine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048489.1">
        <property type="nucleotide sequence ID" value="XM_038192561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048490.1">
        <property type="nucleotide sequence ID" value="XM_038192562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZC53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192561.1">
        <property type="protein sequence ID" value="XP_038048489.1"/>
        <property type="gene ID" value="LOC119722441"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192562.1">
        <property type="protein sequence ID" value="XP_038048490.1"/>
        <property type="gene ID" value="LOC119722441"/>
    </dbReference>
    <dbReference type="GeneID" id="119722441"/>
    <dbReference type="OMA" id="NFFTHAV"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33107" checksum="7DEB4F412A02627A" modified="2023-02-22" version="1">MRSLTDDMEHYHKAFGVYHRLADRNNVMGRWVDSQLPQIFKDLNVALADQDVLKVLSVGPGDGEIENGILRVLHDEKMQYKNFHVTVVEPAVDMVDKYKARVSADASQQQGMTYDWKTQTLDGYTEGNKATKFHFISSLHSIYYAEDLQASLKNLFCRLEPGGMMLVVVISDKSGFGQFGKSFPLLWGNRHHHPTSAEVQAACDKESIPVAQEFTIKVRSNITPCFAEPGAMVDDGRLLLDFFSHVADFVRDASPSHLQEVREFLGSDRCSERVEDDQVYFNGDWKALIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD57</accession>
    <name>A0A913ZD57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049713.1">
        <property type="nucleotide sequence ID" value="XM_038193785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193785.1">
        <property type="protein sequence ID" value="XP_038049713.1"/>
        <property type="gene ID" value="LOC119723223"/>
    </dbReference>
    <dbReference type="GeneID" id="119723223"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="434" mass="48713" checksum="0FEBB0ED32D23DB5" modified="2023-02-22" version="1">MENTFASNATSEYEWDAERLNVNFQYTFLLIVNILVFLLGVPGNCLILRVYWTKTRKTSTDILIRALAWADLAVCLLSIPAIIVWSLFVSGKFLAYSFILPLIDAVINALTDAAIVSSFSITAVIAVERYDCVCRPQKRIFNPRRSKIAILVAVLFAIAIKAGQLTLEICFITSDTLPTSVQAYWEIQAIAQPVLFVVALVTMVVSYGKLYATIRKHVHVGPAHHPTASDERRLNLMRVERQVFCATRPKTPPEINGLNTRESFVDEAVTRFENPPSKSSTTHATSHQMKPNDACTAAHVVSFAHQDSSGPSQPNVIPEPKATPQDNTQSQRQSRPEPGHAPQRVGAAKLQRKTTRMLFITSVVFLVTWIPYLVFTVKYYATPYSDDFEEIIGAISIILLINSVVNPLIYGIANRRFRNDCKEVFREIKCFKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD72</accession>
    <name>A0A913ZD72_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048885.1">
        <property type="nucleotide sequence ID" value="XM_038192957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD72"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192957.1">
        <property type="protein sequence ID" value="XP_038048885.1"/>
        <property type="gene ID" value="LOC119722703"/>
    </dbReference>
    <dbReference type="GeneID" id="119722703"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="50820" checksum="ABC5C6F2CCFBDB83" modified="2023-02-22" version="1">MLLYRGNVTIYAQATTSLAQLDMLVCTFFTCVFQNHSDNCSLAYSPPLTDHPLIWDETGPPPWAPMNESFDVPNNERYKLFNHSLLILAFENPAEAEGSVYSNAETVLYGFVLPVLKLLGILSILSFFFTLCRVPSMRNITNFYLTNLAVADLMVLISETTHQQCVVLTTQTTWDISYLGNSAQAVLTLLPYTKGVGVISSIAFVTLLSYDRYFAVCYPFQHRNLNLKRRAIQAAVCIWFLSFSLDLINFFKQFLVLNVPPMKCLVWPTEEKYKHLSGNVLVFLSNDATFLTLNMVLMYMYFCVFMLSLILTVTFNILLIKGLHAPNPTGDQIRGPSKHLRRVTLIIGINTAVVFVCLLPRAVIALIAIVSLSRKEVNVNDDVAWKLNLMLACFRVLNSSINSVIFNAGSGRYRKAFKQAFCCRKRQQVPTNNIPLQTLPRTDPADRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDT8</accession>
    <name>A0A913ZDT8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049110.1">
        <property type="nucleotide sequence ID" value="XM_038193182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049120.1">
        <property type="nucleotide sequence ID" value="XM_038193192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193182.1">
        <property type="protein sequence ID" value="XP_038049110.1"/>
        <property type="gene ID" value="LOC119722820"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193192.1">
        <property type="protein sequence ID" value="XP_038049120.1"/>
        <property type="gene ID" value="LOC119722831"/>
    </dbReference>
    <dbReference type="GeneID" id="119722820"/>
    <dbReference type="GeneID" id="119722831"/>
    <dbReference type="OrthoDB" id="10048500at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="58316" checksum="58664403BBBBD94B" modified="2023-02-22" version="1">MLVTGNVSPRTRRRTDHTPRGLRSMTQIKRVTSTKVAPFRSPPRDVYFSIEKSIPHGDHEVRTRPNSRQNADTMQDYFPSVSTEQASRPNSKAQPRCESVPITNTDPANLDSTDVDATRSSTAPPNIDLSLKLSDLENLNMRADDVATVAIEKEQQKFHTERRLNISSAMGVRQHGSPRYASLSGTPTGRRKRREREHAYLCMKFRERPCVRTESFLNDDLYDRVNNMSRECCDVLGPKACHECDRLNRRSNSALRNEANFPSIHISAANFSTMTIVNRVRPELNSRQVLERLAQGDISRQSFSRQRTSSDEERQEQDSEVDRPARQKKTSVSAFTVPDGLGFFTNFTDLTAQIFAKKRGERSGRPRHFNQGVGDSSNLPAITDVELVPKKEWERENPANYFGPPMLTRAEIERQKSHPRFYAGAGAKYELPEAPSFDEIAFQASGARHKRIRQLEARSDTPDSEISLFSVKSSHKDDEQSVAPSETETNTVSEDTDAKTTVQDLDNNLEVEPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEP0</accession>
    <name>A0A913ZEP0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-specific adenosine deaminase 2</fullName>
            <ecNumber evidence="4">3.5.4.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Deaminase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-34 deaminase subunit ADAT2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probably participates in deamination of adenosine-34 to inosine in many tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038049420.1">
        <property type="nucleotide sequence ID" value="XM_038193492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEP0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193492.1">
        <property type="protein sequence ID" value="XP_038049420.1"/>
        <property type="gene ID" value="LOC119723018"/>
    </dbReference>
    <dbReference type="GeneID" id="119723018"/>
    <dbReference type="CTD" id="134637"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="192" mass="21265" checksum="151CDEA0AB6B2CB1" modified="2023-02-22" version="1">MAESEISEQHLRWMNEAMDYAVAALDRGEVPVGCLLVYRDEVIATGNNRVNETKNATRHAELIAIEGAIRWCEDRGTRTEEVFRDTTLYVTVEPCIMCAGALRAVGIPSVVYGCANERFGGCGSVLSVHSDDIPSMGKTFKCVPGVFKDRAVQLLKEFYRGQNPNAPVPKIKPQQKNKDDKIIDSDSRTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEX3</accession>
    <name>A0A913ZEX3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049510.1">
        <property type="nucleotide sequence ID" value="XM_038193582.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193582.1">
        <property type="protein sequence ID" value="XP_038049510.1"/>
        <property type="gene ID" value="LOC119723081"/>
    </dbReference>
    <dbReference type="GeneID" id="119723081"/>
    <dbReference type="OMA" id="IEMYRPA"/>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000073">
        <property type="entry name" value="protein fantom isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041091">
        <property type="entry name" value="RPGRIP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18111">
        <property type="entry name" value="RPGR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="777"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="274"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="494"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1411" mass="160755" checksum="3D47248E0DDF40E6" modified="2023-02-22" version="1">MDADSVYDETPVRDPGGGARGHELPQDSEQRRAQQRRAVAKISREELEDKYLRLHDENLVLKRHARKQEEKIKKMATKLLRLVSDRKKQDQEEGGAKRPARKGRDVETEEMLEDLQGKVRELHKQNDLLKNKLMVTKQQLATQGTRSTPYPHVQSRINTGLPKPPPPDNVRKGLRVQGHDRTKSATPRAFRTDVLPRYGHSLLEEAREENHRLEEMIQDLQDHIASLEQDREILQEQVRIKELEHDETLLRLKEQMSAGQRHTAKTNIHENVEMIRLQREVKEKSTKLEALKSQFANLEENLRTVKKSHDTVLAEMEQLNKRYQKEQSKVLGLQSELKESSTSHRTIMELQERIGNVENEKIILQEANEKLLNSAFDAERERQYRANEKQLKLQIAQLEATLKGDLNDKNTLLDKLNEEREQYEKLSKENQQLQISYYQVRQQLDELQEKMKFFTRESAVDFQELEEALIIVKKRKEKGSQDLEFLEKVDEEMNKDLKAQVVSLQAEHAETVSELEKTRNMLILQHKINRDYQIEVEGATTRLEDYKQEYETKLEEYAQLLDIRAARIKKLERQLRDVAYGTKQYKVTDIADDDDYEEIDETIKLERGQNLLELHVTRLVYSREGLKALGDENPSTFVTYAFFEFELQSTPILKGDRPQFDFTSQYKVTVDDFFLQHLMKGSTTLEVHQAIGTEYRTIAACQLRFRDLLDKPQGRLHGTEQLLGLERAGVNFGTIEFWVRLRVPMDQALRLFRERVKAMGYIMSNTRTANQAIATLDQTEGREDTRGQQRDNLNELTVKVVRCAGLKPRREGVQPNPYAVYRFFDFNDHDTTIVTSSNSPEFNDANVYPVVMTAELDQYLKNDTLGVYVFDDTDPEDMAYIGVAKIPLISLAHDKAIRGTFELKQSDGKVNGTVDMVLKWHSTYFAPKLTSGKPKPTKPPTTPSKQAPIIAHRPPIKPVSAQAAPAVTPSKQPKPLAASTPSVPRPRSGTQPADAAASEKVVERTRPLPRPRTSSQPLEPTPRKTASESLKNPVIDVTPPPHEDQTNPLSVTQTLEGDRPAPAPASVQESPFDSEEDAVLDDVERELEGLSRGQEQVEDSAEDVNDLVAQEMRDEFGQDEEKIGKTEQFEDTMFGDTSAPGTGDDDYDEDSIAEEVDIPEPIEEEDEEDGEGEGEGEGEEDEEAELDEEEEEVGAGDAGQEMMEGEVDDDEGMSSDSEALVVMSPAMNRPMSVAAGDNTVSVTIFHLSLEPDTPVITDDNVQRLYVEYHFLGLSGEETETPFSLPKPKAYHNLVYNFKKMFHVDAENNKLQRDYLVSMLHPDDATQGKIRFTVVSEPLEESQDLECEDVGYAYVDVRDMLREDEDMIEQDIDIHYAKEESILIGTMNVSVECVAALRAASAEVDYSNANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFW2</accession>
    <name>A0A913ZFW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM194 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049941.1">
        <property type="nucleotide sequence ID" value="XM_038194013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194013.1">
        <property type="protein sequence ID" value="XP_038049941.1"/>
        <property type="gene ID" value="LOC119723397"/>
    </dbReference>
    <dbReference type="GeneID" id="119723397"/>
    <dbReference type="OMA" id="MFSGPCE"/>
    <dbReference type="OrthoDB" id="527209at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF18">
        <property type="entry name" value="GLUTAMATE RICH 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="592"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="829" mass="91724" checksum="F055C85A45B43DFF" modified="2023-02-22" version="1">MSGGHTPLDGIICQDSMSSQELEGSSNEDGDSNNIGEIPHPSSPLPRSSSSLTVENLRLFEEVTERSAAGSPIVLRSVQDSVRTASPLGPVKTGRASPVRADSRPSSQARVNTPPRISAESLRTGSSKPLPPIGGEKANNDGDVDQDAKSSSTSTDGKTISTNGDRPETNSRLSQPRILSYRRERTSLNDDTDRTIQTAESVTRSERSVSFKDESDTRSQTKSPEKATRSSVKSPAITEVVKRKNPDGTERIGVSIATETEWSWLESVALAGKGEVELQEADQTKTPPSSGFPRKRRHRKGSQSTVGYHSEGSDVENGGSKSRADSFFEEDQNEDSQSESEYSDDDVAPLPTDTLIPSIGPPRIIQYQRESDKAAAYPESPSNRTNTSAGPGMQRIPRFDSFGGSRVSYSSEMDEEDLNGVCEFCQQELKSFPTPEMAQTMTPDEIYCCEDYQQLVEFTLTHSPEDKYPVDELIDIQPHAPYGSKQARRAAKERAAARMRDREMARQRAAGANQANFYASHRLEILDGVARQMKTINYQLSSQKCLDEGWTVRPPTPKDDDGGPPVVFQPEPVIPPPIMSQARQGIRDPKTVQKFYDNGKLFMLMFPDGTGNVFYPSGNIAILITSVEKGQYAYLVYEDIQNNAPLLAMFEPNGCSTCYHSNGNIRMSLDQYGGVFTDSKGAVKKKWSWKDQVTHVHAPPFQPICFAINKVFSVRCMAQDQVYLAFNCSLQSIRFNVGVKLKLVAPQLIPEEPIDDHALYMSEVKAYVELILDKMHNIQKFSKSPKLENLRPSLRLQHDIVRNEQLKNRRGRKYVTTSGGKDAPVVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGM5</accession>
    <name>A0A913ZGM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050165.1">
        <property type="nucleotide sequence ID" value="XM_038194237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194237.1">
        <property type="protein sequence ID" value="XP_038050165.1"/>
        <property type="gene ID" value="LOC119723533"/>
    </dbReference>
    <dbReference type="GeneID" id="119723533"/>
    <dbReference type="OMA" id="CDVCEIN"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001601">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109887" checksum="C7087E79C0FCB78F" modified="2023-02-22" version="1">MQHVQDQSDGHVEMTSPTASVPSTSNDHINLNEFPSHLDYTSALDHDRQVFQGNDSSDVSHHSSGSMKSALYSSGGRSRVTNLMFPKVRRRPFQCKYCTFSCPSATNLSIHMRIHTGEKPYKCGTCSYASARKQNLFRHMATVHKADHVTMCGSTPAMCAYPIGNRSSGEERMPVVENVYGNVQDVVLIDGDPVQIVGRDRGSFPVSEAASSSPHVTPVFPCESATSSSQEEDVVEVLPANNSTPITEFSTRHYADGSRFIFAGGVGAATASSPSPKVDSPQMSVLNHQFDSSKETPKIQTQTSIVSNEVPSIHVPNLISPDRTPVIKPESPLQPAIYKEPITGALKRKQGRPAGHSTLKNILDSPLVLGSKACGSPPSVSSKSLHVSTVDHLEKTGSGIKIIQTEEDLEEVLEGRQRMDIQVAPSGVGKHQDFSPRSMNGGSSVEPLAFSHLRESPDTVYYPGTDTTPGGTKEDVTPSVDAILPSQTSMFRHRHVSTMKPSSARKVNEHKGRSGQMASEDVIMVEQISRTAVPPNISGQRNQMQQSPQKTSQLNIRDHSSFINKTGERVESSNFHGRKTPVRKQYPNTTFDVDRNQRLQHGSLPKDSPASLARTSLTIQVDLNKIMCCAARKLLKAHLVDCDVCEINLPSESCEEQCLTNRSGRCGRGRCSAQEYDEGYLGRERCRSDPRDNEDDQMQSVNRKLTLSRGLGIDTGIVNQVKRGDAIIRSVRQNKMGDGQGEVGMSFLRPKQPFLSSSHNEHPIFAETSVVSSSNVPISSTYFGADAARTVDHLLTRRISEPQESAEYIAFLNAEQARGKAASKRKSSKVKRVCDICGKVCHSRAQLLSHRRVHIETSQLFRCAVCRYCTLHYKLLKRHIVDKHSAASKKNSFTECKICKTAVRVTAVALHMQTVHGHVICGADGKSVDMDDSGKAECSVDHTHTIAAEVQGPKPPDALAMETDNDAVKESEASQAAQEGSTTEDGGSVQDVSIAIKQETVQEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIY1</accession>
    <name>A0A913ZIY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HEY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051753.1">
        <property type="nucleotide sequence ID" value="XM_038195825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195825.1">
        <property type="protein sequence ID" value="XP_038051753.1"/>
        <property type="gene ID" value="LOC119724669"/>
    </dbReference>
    <dbReference type="GeneID" id="119724669"/>
    <dbReference type="OMA" id="GLEHFAW"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="34817" checksum="E848EE6EEFBBFD5B" modified="2023-02-22" version="1">MKRTLSDSDTDEIFDDSIKGSPSQSCPVTARKKRRGIIEKRRRDRINNSLTELRRLVPAAYEKQGSAKLEKAEILQMTVDHLKYLHAKGKHGIDGSFHPYGEAHAYAMDYRVLGFRECASEVARYMVTVEGMDIQDPLRLRLMSHLQCYMAQREFQSRQHYSVPGHPHSQFTSHAAAHGQTGMLPHGQQHAVTSEPSHGTSIPSGVQLTDTSATPGRQMIPMITSSSQEASSLTSCHARLPMPPSTGASVPINSVSTQISPPVAPIQSLHTQYPGVTYNSLPVLSPNGFSPTSSSHMTHSTLVSKPYRPWGAEMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ56</accession>
    <name>A0A913ZJ56_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051085.1">
        <property type="nucleotide sequence ID" value="XM_038195157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195157.1">
        <property type="protein sequence ID" value="XP_038051085.1"/>
        <property type="gene ID" value="LOC119724210"/>
    </dbReference>
    <dbReference type="GeneID" id="119724210"/>
    <dbReference type="OMA" id="WNTINTC"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="340"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="544"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="682" mass="75168" checksum="3EC43DC4CC455C0B" modified="2023-02-22" version="1">MGCGSSKTAVEPGSESEKPPLLVRDEDTRRGEHKDETGNFDGDHGDHIDEDGTHGPVQVPPTKVNLIANGEVCVSQSGVPHENGEAGGEMQPSSFDESHAAVKINERGSLPEEPHATEEINEPSEVRRRVLFITTGMPRTEEDGESAPQRLEPGEVTLTNATDRPISTKSKEDNDCDHEDQTSNQTGTRGDNNNEAMVKTVNLAVDHDVDTFKTGTTSRNTMPEPQKSSNTQSKPAAEIEIPENLSKLSQKSDEVVASNHKPHSAKGNAPFPKKSEPRTEEENLGDNLTPMSHDKWPKTEQTLSVEHETVAKETEKVTSEDGAKLPSRGTGTAQESILDRVRREALEMHNIYRARHGVPPLVLNNTLNKYSQKWAEKMASMRKLEHSPQKNRPNYGENIYYSGSTHFNVSDVKGETSISAFYDEIKDYDYDNPGQRKKNGGQIGHFTQVVWKDSKELGVGMATAKKGNMGYVYICCNYSPPGNWVGRYEQHVLPPISDVPETPKFGSEDGSRDAPGETNNRPADGKPTVGESPLPNGKETPLERVRRELLQGHNAIRARHNLPPLTLNGKLAKQAQQWATKMANTKKFEPSPMSKKAGYGENIFTAGSSNFKMSNVKGAEVAAFFCDEIKQDANMGRFANSWNTINTCTTELAWKTSQQLGVGMATTKQGKMEYVYICCDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLP4</accession>
    <name>A0A913ZLP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051976.1">
        <property type="nucleotide sequence ID" value="XM_038196048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196048.1">
        <property type="protein sequence ID" value="XP_038051976.1"/>
        <property type="gene ID" value="LOC119724816"/>
    </dbReference>
    <dbReference type="GeneID" id="119724816"/>
    <dbReference type="OMA" id="VCAYDRV"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50070" checksum="E0941D4564AB6BCE" modified="2023-02-22" version="1">MKGGKGDAGGSRKRRNEGRNSSPGTSPETTPAKAGTTATEGADRSEASSVEAVAGDRITSTSSRSSRKRGTKPQKGLLSKCFHVGKYVVLVLILPAILNHASLYREAAELKPEGELYDVGWNHKLLLNCAGTGAPTVVLDAPTGMTSDVWCLIQPRIAKFTRVCSYDRAGLGFSERTPMNFSSESYTVVNKERGQPSTVERMSTDLFHLLRLSSDQPLPFIMVGSELGSINARFFTQMYESTVSDLVLVDPLVEGIFELDDGIWSSFWFDHLLPSFQSLQLSAAIGLSRIVLLLGLMEQPITGQVIPEKVVLRQKYLLCQPRHLSSIVDEHYFINESLSQLRTAFQVKPFPESVSVTVITGNYYDEQLPSSLNKVWAKSQQRLMSEAHPNAKHILINGADHHMLYRNPNAIVEPVRKLVKQWRARNNEAYQKSLQTSEDSQQNRNQESKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLY2</accession>
    <name>A0A913ZLY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component MTR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">mRNA transport regulator 3 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052110.1">
        <property type="nucleotide sequence ID" value="XM_038196182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052111.1">
        <property type="nucleotide sequence ID" value="XM_038196183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196182.1">
        <property type="protein sequence ID" value="XP_038052110.1"/>
        <property type="gene ID" value="LOC119724886"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196183.1">
        <property type="protein sequence ID" value="XP_038052111.1"/>
        <property type="gene ID" value="LOC119724886"/>
    </dbReference>
    <dbReference type="GeneID" id="119724886"/>
    <dbReference type="CTD" id="118460"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000035">
        <property type="entry name" value="Exosome complex component MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="14">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="30834" checksum="A96107BA9FA74454" modified="2023-02-22" version="1">MPGDFKRIPCPQETFQPQLYCKSSTKKQLLQENGKRADNRSLDEIRPIFLKAGVVSQARGSAYIEACNTKVICAVYGPHEVQRREGFSMQGSLRCEFKYATFSCPGRRQHQTDSEEKQMGLVIAQALQPAICLHKFPKSQLDIFVTVLQNDGSAFAAALTCASVAVADAGIEMYDVVIGCSLRQAGETTSVLDPTITEDFYSRSVDGDASNHGSVTAAYLPSLNQLSAIQQTGEIEPEVAAKCLQKCIEGSVRIFPVVSQCLIKATKRKAQKSQQTAKKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMC3</accession>
    <name>A0A913ZMC3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-N-methyl-L-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038052902.1">
        <property type="nucleotide sequence ID" value="XM_038196974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196974.1">
        <property type="protein sequence ID" value="XP_038052902.1"/>
        <property type="gene ID" value="LOC119725539"/>
    </dbReference>
    <dbReference type="GeneID" id="119725539"/>
    <dbReference type="OMA" id="MGPGWPL"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="116"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="761"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="853" mass="95927" checksum="44C62FD1551E244D" modified="2023-02-22" version="1">MGIDGMGPGWPLKPSSGMNWKELGENDDLATSLVLDPYLNFTTHKMNTRFRPADARKEFLKELILRFKKSQNYERAYKGLVSGDWARVFFLNKSKHQVTIFKQHVFRYLAMFDKTSGFEVKSCFRYSLEGAGGKIVATQDWSKNDTIPNLVGCIAELTECEENSLKTGVNDFSVMFSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKVLRDIEPGEEITCFYGDGFFGEGNCYCECETCERRQTGAFTPKDTPVKSDENKYSLRDTDRRLRWQKAKNEEEGGASQEEGGLTKNAVPSRLLRRSDSDCSGSSDGNSCPWSRSRSSSQPLSPSLQANQTLVDLIAERKCLSKFDAQLLVAEGYKLREAKVVLTPHKIKEDGTLTVEEGGVRYASRLRRGEERRKSGGRERRMSLNEEPVPSPRVEEAHLNGGLLDTEAPECVTATRRERRRSSECRERRMSLTEEMPELSQETCLGASGVAETARDIPGLRSRARTVAAEGLALDQQSNCSSTDTEVTFNVKRSSKAPKVIEKDLTYESEISDCEMKLKIRGVPRDRVNALKRNLLDSASVMINRHGGKREYREIDSTKNSTELLGRHRKHEGLEVPPLILPKRKMTKYDAELIAEAVQKIPKLKIRMKDPNGCIEEVVTSSEDEVSPRQFSGSCESNPAASQDKLLLDVPDSPSRLTRAQRVLIPGPKLPQSPTSSSKTESPPGSPSVQRARVNLKFDGPERKKTSHQFAPRMSQLRHLYEIPPHPMCQKADKDAPPKHVNSRDVKTFYPSSPDNPKTKSPSDMLGSEERAPQTFKVLVKPVDNRNTRKIRLIFGQRSMDFQVPKTEKRYPTKAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMJ8</accession>
    <name>A0A913ZMJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053033.1">
        <property type="nucleotide sequence ID" value="XM_038197105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197105.1">
        <property type="protein sequence ID" value="XP_038053033.1"/>
        <property type="gene ID" value="LOC119725625"/>
    </dbReference>
    <dbReference type="GeneID" id="119725625"/>
    <dbReference type="OMA" id="FYMIRVR"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="637" mass="72209" checksum="19B7E2EF4EBB8E90" modified="2023-02-22" version="1">MANMYEKVVDVISAAPTDRDDKDIDILLPWFKRKAELFTSLGNDVIRDIIKNCEFRRYKTDDVIIRQGDKGHCFFVVLNGSISIYIAADEDEPPPVSNDDPDAPRDQRAELGTCVRILGPGTSFGELALIETGSVRKASVVADEPSDFIVVNRKLYSRSLKFAQQRDLDEKTDFVNRHPLFKFWKARHKSILAMSLNRKRALFGNRLVQQGSSMLNLLFVLKGQAKVSIAPWKQPNRKLMKRELPRATIETSQVPASESTTRAKSAPYDTTFDVCSIGPGDIIGDIEIACDFTEHVQTVTCLEAVEAFELDMDNFHKVVTKKNPATVDRMRLEAQMKLAARAIRAQNQGLVYFLECLLKKIAVAEDEPMVQEDMRNDLWMTQRGPIIDSLGPGSLYYRATRLEEKLRRRRERRERKENGSETNILSQDQQQDTKVSNANHQQNTAFDADRERKEKQTLESRKHKSFLPATVQVNGILNNSADSQATSVRAVRNPGEDTTHIEPLLLPQANWSATRQETPLDVQQPSPKLVMFVNVKDESCHEMRGGRSHAPAVIPSYLHLHHRYLSRRQSTGSVLLDRWARSAPNTAPAAGGVAVGQDGFADLQALRRQYSADEYKSLKDKLRLQEKRHVRYLSSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN55</accession>
    <name>A0A913ZN55_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052481.1">
        <property type="nucleotide sequence ID" value="XM_038196553.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052489.1">
        <property type="nucleotide sequence ID" value="XM_038196561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052497.1">
        <property type="nucleotide sequence ID" value="XM_038196569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052504.1">
        <property type="nucleotide sequence ID" value="XM_038196576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN55"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196553.1">
        <property type="protein sequence ID" value="XP_038052481.1"/>
        <property type="gene ID" value="LOC119725189"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196561.1">
        <property type="protein sequence ID" value="XP_038052489.1"/>
        <property type="gene ID" value="LOC119725189"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196569.1">
        <property type="protein sequence ID" value="XP_038052497.1"/>
        <property type="gene ID" value="LOC119725189"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196576.1">
        <property type="protein sequence ID" value="XP_038052504.1"/>
        <property type="gene ID" value="LOC119725189"/>
    </dbReference>
    <dbReference type="GeneID" id="119725189"/>
    <dbReference type="OMA" id="GIWAIAD"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="262" mass="28746" checksum="7C61C12D650E3318" modified="2023-02-22" version="1">MVSFEAPVSTLSCFGKCFKWSLYLFCVLFLFGGIAASGVGVWAIVHPTSFRIVILTNTRMYVFAAIILIGAGAAATLVSVLGCCGARYENRCLLVFFAVSMLLIFVAEFSAGVLSLAFYTQIETFASREMRDAVLLKYGQGNYIETTDAYNYMQQTFDCCGFEGDSHDAAQLYQASLWFDANYRIQVPPSCCTRNPNGEPINLAHCQSRFNTHLAFINNIGCKEAVKAQGIHFATVISAVGIGLAMLQLIGIVLAFCLFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNP1</accession>
    <name>A0A913ZNP1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear envelope membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear rim protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052994.1">
        <property type="nucleotide sequence ID" value="XM_038197066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNP1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197066.1">
        <property type="protein sequence ID" value="XP_038052994.1"/>
        <property type="gene ID" value="LOC119725597"/>
    </dbReference>
    <dbReference type="GeneID" id="119725597"/>
    <dbReference type="OMA" id="WSIWFPL"/>
    <dbReference type="OrthoDB" id="10050858at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040:SF1">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="30998" checksum="BDB815A87AC46600" modified="2023-02-22" version="1">MAGVAFVPKATVFVIIAALGLCVCFLTVFQFGVFLFKEGFHAGQHHGQRTFGHAQHDATNPYVSDLLLDLLLVAAFVLQHSLMACRLWKDFIQWLGLAVVERSLYIMATCGTLQLVMSQWQLLFPESVLWSFDTDSRWVWVSFSVCCFLGWLCVIGFVMVLDYAELVGIKQVYYYVIDLDPPIHMKSREYQRLFRNFRHPVLTGLLIILWAVPVMTVSRLVLALSLTVYTFYGHSLDMRDYDYICVQHRLKKVTLGSPQGFRGGRATSVSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP30</accession>
    <name>A0A913ZP30_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fanconi Anaemia group E protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052870.1">
        <property type="nucleotide sequence ID" value="XM_038196942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052878.1">
        <property type="nucleotide sequence ID" value="XM_038196950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP30"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196942.1">
        <property type="protein sequence ID" value="XP_038052870.1"/>
        <property type="gene ID" value="LOC119725519"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196950.1">
        <property type="protein sequence ID" value="XP_038052878.1"/>
        <property type="gene ID" value="LOC119725519"/>
    </dbReference>
    <dbReference type="GeneID" id="119725519"/>
    <dbReference type="OMA" id="LRLPWIC"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039685">
        <property type="entry name" value="FANCE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021025">
        <property type="entry name" value="Fanconi_anaemia_gr_E_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32094">
        <property type="entry name" value="FANCONI ANEMIA GROUP E PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32094:SF5">
        <property type="entry name" value="FANCONI ANEMIA GROUP E PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11510">
        <property type="entry name" value="FA_FANCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi Anaemia group E protein C-terminal" evidence="2">
        <location>
            <begin position="360"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="581" mass="63507" checksum="EC40E6B10A548990" modified="2023-02-22" version="1">MEFGDYIMKFPPYWRGVFAFLSKDHQPTVGADSWLVENREGALTCRTSRYCPRGHHVDWSRFVEGLCEKEPTQVAGQLAFLPRILLLPVNVQRNTVAFLSHHLSEIPVPCLEKLLDSLRNCSVSDEWTKHHLRTLQDFICRNRCLNYGSGLSADDSQMKLTRGSRDAFENVCRQIRDKDGILDEGGGFTLQFDWLPEAVSSNRHTCQHSRCFSSEKLNSDEAEKVVPASQEESLKKDSAIPNEGRSTSPEVIEIEESPLPSPMEVEVAAAPNLPERRSEVSVVNEIASGDFGGQSSQVKGEVVGGQRADVEDIGRKQERSRNDVVDAVTMDKLASLKAALCNSSGPVPSELARVIIGIPIDKMEAVCDILELDSTPAAGLAALAQELSGFSLELGHSSATILARRCFGQQIRDLTQTAPRTLIAAAIGFAKAFPKPLIEGAFLLALAGDGQVGGSTSHQCDLVVKVLKEALTNESRVYLLSKLLSIQTLQWSDDLTGLFQTALACKLELDNHTLEMFVTALEHHGSSRSSCAKFAKLLLAVINRFSKQISAAGLAALQRLADANQTFLKKALLGAIKRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP56</accession>
    <name>A0A913ZP56_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052900.1">
        <property type="nucleotide sequence ID" value="XM_038196972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196972.1">
        <property type="protein sequence ID" value="XP_038052900.1"/>
        <property type="gene ID" value="LOC119725541"/>
    </dbReference>
    <dbReference type="GeneID" id="119725541"/>
    <dbReference type="OMA" id="DDTHQDE"/>
    <dbReference type="OrthoDB" id="10584286at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="18651" checksum="FE76F967ED77CE43" modified="2023-02-22" version="1">MVQLSVNVDGQKGDQVKKSPDSVEVPIPAKPYAPVAVKRGRCCSKTVVCISVISVVILLVVGATLLGVFLSRHKSWEDCFNWDDTHQDEGSHSGGGSHGDGPHHGGGSHGPHGNWTHGGHGGHGGGHDGDHGGHGHGGGDDGDHGGHGHGGGDDGNNGGHGGEEDGGGHRYPGNEGDHFPDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRG3</accession>
    <name>A0A913ZRG3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054247.1">
        <property type="nucleotide sequence ID" value="XM_038198319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198319.1">
        <property type="protein sequence ID" value="XP_038054247.1"/>
        <property type="gene ID" value="LOC119726584"/>
    </dbReference>
    <dbReference type="GeneID" id="119726584"/>
    <dbReference type="OMA" id="DWITANH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037091312" evidence="8">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="129"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5 6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="38960" checksum="33997EEB653749CB" modified="2023-02-22" version="1">MKTFVLLCLCVAAASAALAPLRKVNQHIPNRYIIKLKEGSNLDEFVDRLETRTRGLNIPVAVMKKFRKVMNAFVASIPDRFIDSIRSFDGVEYVEEDGVVKTQAVTWGLDRVDQRYLPLDGSFNPAGTGAGVNVYVVDTGVNPSHWEFGGRAVAWYDALGGSGTDCNGHGTHCAGTVGSRSYGVATSASLYGVRVLSCIGFGSNSGVVDGIDQVGLNGQLPAVVSMSLGGGASTATDSAVQNLINLGFTVSAAAGNENVDACNSSPARVSDAITVGATDSSDARASFSNYGTCVDIFAPGVDITSTWYTTNWGTNTISGTSMACPHVSGAAAVMLGNNRSLSPAALKSSMLASATSNVVSNPGWGSPNKMLYIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT65</accession>
    <name>A0A913ZT65_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054380.1">
        <property type="nucleotide sequence ID" value="XM_038198452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT65"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198452.1">
        <property type="protein sequence ID" value="XP_038054380.1"/>
        <property type="gene ID" value="LOC119726674"/>
    </dbReference>
    <dbReference type="GeneID" id="119726674"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="15"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="442" mass="47776" checksum="2E9AA13C0833CE36" modified="2023-02-22" version="1">MGRVQAGHSHQGWYAVLCFFVSFVLWSWVLKALGVMLPTLQEQFVAQTWLVGWMIAIINAVSCVTGLLATPLEAMFGTRTVVTISGFMLGVSMIIASFSTSIVMFTSILALAAGPALSVVPILTRALIGRSFPTNYGIAAGIGGSGAPIGLITAGPFAQLLLDTYGWRGALLILGGFALHLGVCGAILRSSSTDETETNSSYQPLSTDANEEPRVGSSSAEEKGNLKQSSYNTFKDPLKSMVKHIGISVCFQVSFWFTAVILILGRFVDDHWLIYYVSQAEAKGFSPYEAVTFTTAGGVGNVVSRIVFGFIVDRNLLNLRPALVLMIVLSSSALLIAPWLNTYWLMMAGSFVFCAGNGAIALLNDLYTRELLGTDLLVCAFAWMETLTAILGFSLGFYPGWMYDQSGSFDWAFFILGCISALSLVGLLMEWVLSRCKYQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU02</accession>
    <name>A0A913ZU02_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054695.1">
        <property type="nucleotide sequence ID" value="XM_038198767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198767.1">
        <property type="protein sequence ID" value="XP_038054695.1"/>
        <property type="gene ID" value="LOC119726917"/>
    </dbReference>
    <dbReference type="GeneID" id="119726917"/>
    <dbReference type="OMA" id="GDGRIPK"/>
    <dbReference type="OrthoDB" id="6282425at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="17683" checksum="1533A7F8865018A8" modified="2023-02-22" version="1">MDDGRIPKDVLYGELAIGTRPSERPTLRYKDVCKRDLKVCSVSSADLESATSDRATWRSTVTAGVLQAEERRKSQWEERRTRRRQRLQAAPIATTTNYTCSKCQRTCSRTDRAVHSKRREEKRREEKRREEKRREEKRRKEKRSKSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU38</accession>
    <name>A0A913ZU38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055243.1">
        <property type="nucleotide sequence ID" value="XM_038199315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199315.1">
        <property type="protein sequence ID" value="XP_038055243.1"/>
        <property type="gene ID" value="LOC119727441"/>
    </dbReference>
    <dbReference type="GeneID" id="119727441"/>
    <dbReference type="OMA" id="HQNDKCD"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001706">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="959" mass="106567" checksum="CBCB438623C43A75" modified="2023-02-22" version="1">MVMTLSACFICCPQDIKLHIMQTLLETEQSYVHSLETLVKSYMRPLKSPEYSHLCSDPGMVDVMFYKLPEILNCHENFLQQLQMRINHWHDTQKIGDIISASMAKQPVLDTYTAFTNNFNRAKELISKASTKPAFFKFLEERTKEHKERLNLDDLIIQPIQRIPRYELLLKELIDNTPEDHPDQESLQLALNTVKTLATAIDESKNKADLKVRDEQALRDLEGMIDGHVALVSPQRRFIRQYGVTEMVRVAVQKGARKDRCVFLFSDLILCASVKRRSGGIRRPSISALSPATLPVEACKYKLAWKLPVEDVEIVKSPASTQQANQERDLGKLEEDLSILSRISGLTETLSSPHQGLDEVLKELTETVSKRLAEMQALPALPTALLSKVELTATTHEGIESFVLLFQGQEARQTFENDFAEAKKKLAARSKDHFPPVFLYPIPIMKTRSGMQFSCAAPSLGTMSNSLRDVWVCNSDGYVGQVCLLSLTPEPTVAFCISVCSARILCIAPVPGAQDMHSIRGRVHLRVPKIPLDTGQTRPLQFLGETTANGRCIMPVSNTLNQQASDIMPFDSDDSEDEDEVAMSPGSGMAPEIRLQVDDVPMEEASSEEDLERTSSSNNLEEMSSREDLEVLQPTMWLGTEDGCIHIYQCTDNIRTRKSRTKIRHPAAVQCILYLDNKVFVSLANGDLTVYRREPGHAWDTKNPLTVTLGSSTTPISKMVSVCSKLWCGCQNNILVVDPDTLNVEYQFSVSNDTQKTVHCIVSSGLGVWVSLQATAVVRLYHAGTYENLCDVDVTQTVYKMLAGSDAIIRQHKAACLRITALLICKELLWVGTSAGVVLTLPHPKITTATTSARDISIPNGSGQGHTGHVRFLTAVDIPSGKPPAPVQRKISEQVQDRTREIQPLEREQHQRRASATAAIVSNMMVISGGDGYEDFSATAPNEAAGKEDSTNHLLLWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUF4</accession>
    <name>A0A913ZUF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054870.1">
        <property type="nucleotide sequence ID" value="XM_038198942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198942.1">
        <property type="protein sequence ID" value="XP_038054870.1"/>
        <property type="gene ID" value="LOC119727065"/>
    </dbReference>
    <dbReference type="GeneID" id="119727065"/>
    <dbReference type="CTD" id="400"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="181" mass="20297" checksum="B57D4381932E4D9F" modified="2023-02-22" version="1">MGGFFSRIFSGLFGSKELRILILGLDGAGKTTILYRLHVGEVVTTIPTIGFNVETVKYGNIKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSSDKERMGISKSELVAMLEEEELKNALLLVMANKQDMEGALTHTQVAHDLGLSALRHRKYQIFKTSALKGEGLEEAMQWLVSELKTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV77</accession>
    <name>A0A913ZV77_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055449.1">
        <property type="nucleotide sequence ID" value="XM_038199521.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055450.1">
        <property type="nucleotide sequence ID" value="XM_038199522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055451.1">
        <property type="nucleotide sequence ID" value="XM_038199523.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055452.1">
        <property type="nucleotide sequence ID" value="XM_038199524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZV77"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199521.1">
        <property type="protein sequence ID" value="XP_038055449.1"/>
        <property type="gene ID" value="LOC119727586"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199522.1">
        <property type="protein sequence ID" value="XP_038055450.1"/>
        <property type="gene ID" value="LOC119727586"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199523.1">
        <property type="protein sequence ID" value="XP_038055451.1"/>
        <property type="gene ID" value="LOC119727586"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199524.1">
        <property type="protein sequence ID" value="XP_038055452.1"/>
        <property type="gene ID" value="LOC119727586"/>
    </dbReference>
    <dbReference type="GeneID" id="119727586"/>
    <dbReference type="OMA" id="DCTIQRM"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="267" mass="29917" checksum="173DF6BA20C5A3CA" modified="2023-02-22" version="1">MDVKLTSSTPSDYGTNPRDEDDPPPDYDAEASKGDPPSYLSIIDKIEEAKSTSSTQTDFVTTTVKIILNTVMATICLALSMAVPIAMIVMGAVYMNDCPAERMIPIYLTVFGAVYNFKASIDLCNRAIKRKHKRRKLFGSDPQDEIKIVIGLNWFSRLIGILLFGFFIAGNVWVYRIYAPSNNPTSPNYCYGPLYYFAFWVITVVYILLGLCCCGVTTIFCIGFAFCFKILRKVKKFVEALRSVRDAAASARENDAAEEEEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVH8</accession>
    <name>A0A913ZVH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038055499.1">
        <property type="nucleotide sequence ID" value="XM_038199571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199571.1">
        <property type="protein sequence ID" value="XP_038055499.1"/>
        <property type="gene ID" value="LOC119727615"/>
    </dbReference>
    <dbReference type="GeneID" id="119727615"/>
    <dbReference type="CTD" id="4668"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019377">
        <property type="term" value="P:glycolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036880141" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="45313" checksum="49565888EA707E9C" modified="2023-02-22" version="1">MLAITLLVLCAVGTQALDNGLARTPPMGWLIWERFRCNTNCKLDPNNCVSEKLVKEMADRMVEDGYKDVGYEYVNLDDCWSDKERDAQGRLQADPDRFPSGIKSLADYIHSRGLKMGIYGDYGTKTCAGYPGSLGHLQTDAQTFADWGIDMLKLDGCNSNVTTMKKGYPEMTKYLNATGRPILFSCSWPDYERAAKIPINYTLVADNCNIWRNYDDINDSWGSITGIIDYYDKTQDTLVPAAGPGHFNDPDMIVVGDQGINVNQANAQMAMWSIFAAPLLMSNDLRNIQPVYRDILQNKEVIRINQDPAGKMGKRVLTYNSTVDIYVRTLAGPLEFALMFLNTAAKPCTVTVSLRQLGFTYQPGFEFEDAFDNGRFVGVFNTDQMYNYTIKATGALLYNLYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX56</accession>
    <name>A0A913ZX56_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055870.1">
        <property type="nucleotide sequence ID" value="XM_038199942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199942.1">
        <property type="protein sequence ID" value="XP_038055870.1"/>
        <property type="gene ID" value="LOC119727867"/>
    </dbReference>
    <dbReference type="GeneID" id="119727867"/>
    <dbReference type="CTD" id="157777"/>
    <dbReference type="OMA" id="SICLVPR"/>
    <dbReference type="OrthoDB" id="2015372at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058769">
        <property type="entry name" value="MCMDC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF75">
        <property type="entry name" value="MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26063">
        <property type="entry name" value="MCMDC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCMDC2 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="3">
        <location>
            <begin position="330"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="694" mass="77596" checksum="18345F17C058CCF2" modified="2023-02-22" version="1">MQDQFSDSQLQLQESSLKYLDKTQQLEKLKKECLAHSDSKESTIYPFIIKIDCTEITEIDAILGNVVLHQPQEARKIFQEVCYVSLTSLNLLPAEVTCSQVLVNLQLLDLPHLKSYQLSTAELLGCKFDSRFYKFAGTVCSISSPIKYSRCAKYRCPESKCYGAADNFYIRCHIEGAKEQQTVRRDFNCVYCGSILKEDVTCRVLGERVTVQMVEGDVFPLQRQDGDTHSGRYCQSVTVMLRDEFFNMQLGGCYCVIGIPVKEFTGNSSVSVMIEANNVFKMKPRIPTEPRIHLSETLRQLLANRAQSPWSFSASLAYLFAEGVTPPGTYHRLKLCILLSIIDATSRSYKNDSQGFLDLVAVGADSNLIRRLLIYGASYARRAIIHSGSQPLLASLHRDPSGPGCYTIDGGSTLLAHQGVCVLGEIDSLKRDAKQKLQNVLEHRVIQIDLPRQLSSGSSQQQLFPVECNLWGYANSYKTQEVDEESLFSASEVKRTPKQSIVESFPMVLVCDSPNPTMNEHAELNIIKQTLLGAMADPDQLGGRKSIIGPSEIKQFLEIASATTVEFSAPAKQLLKGYFVGSRRVRSSGVHGTPFPPMALQTLACMSRALAKLNLRNTVLEEDAAFAVLLYEEAVTARYGYSILNIQSKPHFRDGNISEHLGPENDAFMRSFMTRLSRFCRSHVPDFNMYESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXS2</accession>
    <name>A0A913ZXS2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase D-interacting substrate of 220 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056115.1">
        <property type="nucleotide sequence ID" value="XM_038200187.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200187.1">
        <property type="protein sequence ID" value="XP_038056115.1"/>
        <property type="gene ID" value="LOC119728114"/>
    </dbReference>
    <dbReference type="GeneID" id="119728114"/>
    <dbReference type="CTD" id="57498"/>
    <dbReference type="OMA" id="HADMCGW"/>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="461"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1735"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1496"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1526"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1638"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1674"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1735"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1805" mass="199814" checksum="159905A3756A9E13" modified="2023-02-22" version="1">MVNASRMPVATQNSSGGPPRAGLRRNSSFSNLCSYTKRSFKRLLSLGDEPPIPVEGGQTALMCAAQAGKLELVQELLDRGADIKAIDEDKWTALIFAAKEGHLDIVKSLLAKGAEIDHTDVNGWSALMWASYKGHADVAEELLELGASPNVQAHHGVTPIIWAAGRGQTGVVECLLSHGAKANSADKYGTTGLVWAARKGHVGCVKALLHHGANVDLAGMNAWTALIVASRGGFTEVVKMILDEEPNVNAVDKDGMTSLCCAAKEGHTEVVKLLLEQSAYMNIQDKNDETVLIHAVKGGHLDIVKLLLDKYADVDIQGSDKKTALFWSADKGLVDITEALLDSNANPEIPNKDGETPLLRAARNRNREIVRILLDKNAKVSAIDKRGDTALHIAIRFRDKKVSELLLRNPKDGRLLYKPNKEGETPYNIDCNHQKGILTQIFGARSFTPGEEADSEMSDLCSSALADILSEPTLAPPITVGLYARWGSGKSFILKKLQDEMRQFTNHSSKPVFRFSCIVFIVCLLLSAVLGAAVLFIFSEAPGASIGVFFALFFFLYFLLGVVYLGNRKKWRGMRATSSWLAKQLNYLRLILAMIYCNPPPQPPQSSKALPIRFIFGDHLHLSNIGGETPLSKAVTSLSAAVERDLGFMASRVFRVTRNKYTEGLTKWKRCCCIPCFLLTLLVLACFVAFLVLLFYYFLNTRAVYTNRQHIFIAMIVTGSLVGLALLVNSIWIIQFLYNLIWSPQLRLRRGASGPLKLEADTLAQFVHCVDAFQGSQTRMVVVVDGLDSCEQEQILHLLDSIKALFSSPDSPYITILAIDPYIIAKAIDQNLHTVFKESNIRGHDYLRNLVHLPFYLEVGIKLRENSESASPTANHIPPSNPKQLRWGLPSIPEMPENDNGRRVRFTQKIRPEASQQAGTPSPRPDRHQITALPNKEDSESQALGRMNSGTTRDVSQLLASDEQFSDLSPRSMSRLLNIVSITGRLLRANNISFQWQRLASWVNVTEKWPYRTSRMAVFYQNNEESFDDELPLKAVYESIQDEIPASREIEPLLDLDQDSRSFLVYLTKHTPVLTVGDLRRFLPCACHLDPYLRKQIKDSLESQDMAGALPNISALPRPQSFGSNFPNQVSSRSSVYSALSDTPSRLSYQMAAINPFSKKIPSPAISGTPSPGFLTVKDVCDRLLQLEGIDKHSIPRYQTRIAEHNVNGHVLLQCDLDELKEVLGMNFGDWQLFRSLVMTMRGQALSCTHSPSMSSSDVLQMETSQVDSGANGLNAGAGTNNSPGAISPHSQNDYLNLSFEELRKSSQHSSQRSSLHNSRLSLGTSVSESSQFIDQSGTSEAEEESSSPKHVPRTDHASLLRAMDEKGGDVDREGITQFMGVVSDCEYDELPEQYEMSNVIPLQDVGLTPAEETIPAVSSGVGLRRNHSLKSEDANRPKTNGIHLVDGLVSERTAGVKHVGISLPSEQKAKRQRSLSEESGESEPTENQPLLEKNVTNEKDRGKHKSDAEHRRSPVKTAKVQLTSPKKENGHMDAKPSQRLYQPEPNIISPDLKAQVVEDVERMFENLEVELAHRKQQSLPLEVPPPLEPALPKPGNVRFPKSPFRGEQQTHDLSLLAGYSSFTPMLRELQSVPETDVMSTTTNSDEVLSTPGSTDQPRYRRPLVRQSQSSDLLTRDRTPPPPRTVDEKPMMRSVSQPNRFTDAGLELTQQESPQQRTLDQSFDEFIMLSLEEQRKKRTVSDSEELEKPPKNSGRGSANPFWRQSAPSLGLNCDKKDNVFTVNVGDPGPSNTDRRTAVHKGGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZT5</accession>
    <name>A0A913ZZT5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057143.1">
        <property type="nucleotide sequence ID" value="XM_038201215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZT5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201215.1">
        <property type="protein sequence ID" value="XP_038057143.1"/>
        <property type="gene ID" value="LOC119728817"/>
    </dbReference>
    <dbReference type="GeneID" id="119728817"/>
    <dbReference type="OMA" id="SSKHHVE"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037529466" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="9">
        <location>
            <begin position="679"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="821"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1207" mass="131608" checksum="FE2B68223FFB930C" modified="2023-02-22" version="1">MKHLLKRHHFWLVILLTLAFPEMLASALDLELPDNKQPQCVGISRGKHFVLGFIDNINDGYLASRELFILVVAFSNQQTTVTVSSKHETEGKPFQETFVIDAGGFIKTNIPVELVMENTERSQKVLDISASSDVSAYGLMYQDYSTDGFLCIPTNNLGMQYVVTTSRPLGDQRSQFAVLGTEDSTLVQVTVRGAVTFQGQSYSPGDVLRFTVNNLEAVQIQGNMLVDVTGSIIQSDKPVAVFSGNECTNHAGSACDTVTEQLVPVKSWGQKHMYTAARSDDDNIYRIVAYFSETNLTIPGLEHQSLEPGEFWEGRLSGSGLVTSSKPALMMQHLASINGITVDPSIIQVPAEEHFGFVFGFTTPPHSAGDSGGYFNFINIIVKNDSRETVYLNGSLINGTNVHESDVPHTSYMSLTVQLPKGEGVYYVEQTDPYSSPLSVIVYGYESSESYGYAAGLSLPSNKQVLSLTPYYLRELGGELFTVTVPCLQTNAISLQNAMCKFSTGFGDVLVPGERTDSYTVVCITPTFYTNGLTSVYVSLDDGESFPYSGIVYVAGEEDLAPLVQIQQVTSEYGNGIIDLTLGDPIVLSWDPRSLGEGVSHVTVMMQDTDYDSDGNPVLMEGVAVKNNVLNNGRLTIHASDLETLTSDGLSLTAFYLTPIGMTRQRSIGSLLLRLRHYGPAVIIVTAITCEVSKYQLKDTTPTGLPSCPCNTAQADRDILNFQEANFMNSVFHPGAANCYRSVNSLPTGAGQQCCYGNDGNILVGPRGGGTADRYSPGEHFWKHQWFDVLPWLCSCVLSNDCNNYYKYRPSDDCSDYEPPRPAGGTGDPHLTSLDGYKFTFNGAGEFLMASSAENNLTFQARMERYRNTNASVYTAFVLQTNDSSKVQIQMSDMAFVLQTNDSLKVKETLILVDGEPLHLDSIPFKVHHLRGVQIRFNSDLTKINIAFNAGIAVTVYIDTEVMSFIAQLDTKFEGRVSGLLGNLNGNPDDDLQFPNGTIMQPGSSLKELHEYGLEWLVAKEDSIFTYISPFDYNTYHFPEFSPNFEVPDLNKVSQEIKDLCGDSIECVFDAVITGSLSFANETLVVESTISEVQKGLVKIVSCGYPGDVENGKLSGTVYLVNATVDVACDDGFSLKGSSSLTCLKDGQWSSDLPICIDVEDGEKKGLDGGIIAAIAVGGVLAVLVVCGLMYFSIKYVLHKGKVGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZV8</accession>
    <name>A0A913ZZV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056606.1">
        <property type="nucleotide sequence ID" value="XM_038200678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200678.1">
        <property type="protein sequence ID" value="XP_038056606.1"/>
        <property type="gene ID" value="LOC119728438"/>
    </dbReference>
    <dbReference type="GeneID" id="119728438"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41765" checksum="E40ADEAF761DCC3B" modified="2023-02-22" version="1">MNRKGLRDKFFAIVIHVCGMVFAITAVHNRTMPYVTLFPWLVTDFRLIYVKVVITNERLFLLVHVLECFQFCLHSDTNNDTEDMPTMSMILAINDKLPYPHLFEGLEALQMAIYVCTILNECVVLLTNLLEKSSPIENHRSAVKKVYISCLIISVCLAAGGFLGFHIIFGNNIKGTVEPILYDHVTELYGMPGYAADTDAINRLQINEKCCGATGYADYFNSYFASSPMYGGRVLPVTCFKLLDDGCVNATSADKINISKIYIKGCNDALVAMYEYHYRMLFLPICTAWAGLYDGYLRLLLLRKRQPKKYEGRFALRVHSEPENQDQEIDEPVPGAGDVAMANAPEPETETGQPFLKPGTSSRKSHSSSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A027</accession>
    <name>A0A914A027_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057054.1">
        <property type="nucleotide sequence ID" value="XM_038201126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A027"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201126.1">
        <property type="protein sequence ID" value="XP_038057054.1"/>
        <property type="gene ID" value="LOC119728752"/>
    </dbReference>
    <dbReference type="GeneID" id="119728752"/>
    <dbReference type="OMA" id="CISAMIN"/>
    <dbReference type="OrthoDB" id="5970026at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="304" mass="34437" checksum="9F32F6CDAB53357F" modified="2023-02-22" version="1">MSENFVTVMRYAVTITSVAAVLENILVLAVLAGTKRLRIKYYGFVYNLALADLCFAAFAISFPWAENSPVFALMMACYIVSILTIFAVAVNRYLALSLMPPSRYDAVVTGRRLFGVCVLIWAVSLLLNLLPVLTVSPGVMFWIYGLVRPLTVFIIWLITAIIYIVVFRKIKMYTPPMASNPGVTASAESIQAKTRVRQTRKLLITFVLILAACFVCWMPYSIVRVIAFAEPKDLESPIFFDAYWFAGWMYCISAMINPLIYWGRLDEFRQGFYALFCRCIVKTDFKEIELDETEQGKTVGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0V2</accession>
    <name>A0A914A0V2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057225.1">
        <property type="nucleotide sequence ID" value="XM_038201297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0V2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201297.1">
        <property type="protein sequence ID" value="XP_038057225.1"/>
        <property type="gene ID" value="LOC119728866"/>
    </dbReference>
    <dbReference type="GeneID" id="119728866"/>
    <dbReference type="OMA" id="SGAHENA"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="12">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41035" checksum="BFEE2DC6525BD3DB" modified="2023-02-22" version="1">MAMFLPRHRLVSDGLLSGRIFVFTLFTTACKFLLVFSQPQNAPGYLGCYEDCEGSKCQSHERVLSIGPIDHDPQSVEWCFRRCLEIEFISYKYAGLEYSYECFCGNNEDYDRHGEKDDSECQDRCTGNSDQFCGASKRISIYRISQGVCSNDIVPPTNGAHNITNPRSLSYNLKNFKFFGTRVDFSCDPGYTLHGASSIECIETGYNNVTWSDSVPTCEADDYGATSTDRYNSSSTTAKGTNDTHKGELETGMIVGIAVGIIATLTVALLVVVIYLRKKRANKRTGRSDVAMDTMGPTYANTSHGLPVVSQPSTEPTQAAPPVYSHKDAHYDHVYATPDDVTVPGDAPTNRDDGESGWVENTVYGCESFPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A115</accession>
    <name>A0A914A115_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057517.1">
        <property type="nucleotide sequence ID" value="XM_038201589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A115"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201589.1">
        <property type="protein sequence ID" value="XP_038057517.1"/>
        <property type="gene ID" value="LOC119729083"/>
    </dbReference>
    <dbReference type="GeneID" id="119729083"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="488" mass="51785" checksum="EA7DB33F38B35359" modified="2023-02-22" version="1">MLSQMSSSESEARHWPILLAGFVVNCLTYGAASAIGVFYIEWFAEFPESAALIGWLSSSLLTMLLCVSPLAGALTRYFGVRPVAMAGALLSFPGILIASFATDVYVLIITLPFMAGIGFGMSYTGVMVIISEYFHQHFALAVGIATTGTGVGTVVLPIFFGYLIDRYGWRGALLVFSAVQANACLCAAIMRSPPRKTKTGEDGKKEVTGNYGSIGERRGIQGGSPYSHLVEDKDEDDDKIVSSSQVNSDPCSEAKTAKRIITERLMTLLDRTGISLFWTNRVFVTFLIISITDAPIYGITLPYLTALAESVGVPELQATTLISIIGVSYIIACLISGQLVDARVAGPACMFGSAVALASGALVLFAATASYPVFAVCASTIGLAAGVYIPMTSVMVRRIVGQERYPGGIGVVMVIVATGNMASAFIGGTLYDMTNSYSTAFVFAAVVSGLCAATVLGLHLLWTRLVPDDRWPTITTRSSNTEARNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1X8</accession>
    <name>A0A914A1X8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038057853.1">
        <property type="nucleotide sequence ID" value="XM_038201925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1X8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201925.1">
        <property type="protein sequence ID" value="XP_038057853.1"/>
        <property type="gene ID" value="LOC119729305"/>
    </dbReference>
    <dbReference type="GeneID" id="119729305"/>
    <dbReference type="OMA" id="KEWDAGY"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF79">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="422"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="694"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="761"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="829"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="970"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123703" checksum="376F6C9E78BF3C4A" modified="2023-02-22" version="1">MPGRLRYVGRYIINDRTLGKGNFAVVELATHSITKTKVAIKVIDRSKIREDYVRDNLYREARILAQLRHPNVVRLYETISSSSLYCLVTEYAGGGDLLSLVRGQREGRLTEAVARPFVRQLVSALHHLHERGVVHRDLKMENIMLDEKRKNLKIVDFGLSNIFSPDCLLKTHCGSPEYAAPELFITDQEYGPEVDIWSLGINMFAMVTGRLPFSTPYSENRRQRLMQQIQNGLGVIHGREMAHLSDECQELLSQLIEPSPELRLPLLDIEVHPWITSLGETPFCPYQQPPKDADVKRLIIDKMAYLLNVSAAKIETNVHEYRLDEVSAIYNLMMDQYRLSKGFWDVDHTLKREVKRPKPVEVVVRPKTPPQEMPEPEEQEERMELRTPTVIGMVQPSKRNQDRRTCLSADFELSAVSCEGRPRRNRAKTATFPQTGTKTRPIGNATTANSVLARYNNFGPPSSAQQPKVCTCPSASPANNTNHHNQPKKSENGQYDGLHQPIGGSVSNDKDNQSDIANEHQAHSGDGPIGESVTSRECTKPPIRKREAGEIDDQISQIKTNAETAHDMKVIDMVKCFNFKHGYIIKETALSNSNSRNDQYTPQNDSEGNKPSVKLCSAHREQMLSGTLPKQDVHSCQSSRANSPAKTAAQRNELLRQQMQLPTRPVNAHFRPHQANPSLQETLLLTKRAWHSRNPQQIVRSGRRTTDNSGQGLVTRSSPATNGHQCIYSASRSGSESPRARLRTPIATLHSMEKGTQFSTTAQEWQGDNIKSGKTKEGARRNAMPQRLDWKRSSAGKPRGWTEDGEAMIREGAEHGGGINTMKKLQEMMSRDSVHQTVPSGNIRVKSAKIGTPRSIERCQSPQRKSTRSGAGSRRVPSSDKHKSCTPQAYKGPYIMDRHKGQHQRSHTHPTSKHDGVIDLNQQHMVSLLQEASVKFEDSLKAESRKSQAVRSGDQSNWRRGNKPNQTPRQTQKQQQQQQQQQQQQQYVDEGDLDEGTVALQLGQRVQLVRGSLAINSKPPPILSNNMAPEHVFNVQASRDVQVVQKRSTKNKRHPSRIVDKKINKEWDAGYRLERKVSDTIKRVGSAVGKTPDLLLNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5R8</accession>
    <name>A0A914A5R8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058849.1">
        <property type="nucleotide sequence ID" value="XM_038202921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5R8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202921.1">
        <property type="protein sequence ID" value="XP_038058849.1"/>
        <property type="gene ID" value="LOC119730149"/>
    </dbReference>
    <dbReference type="GeneID" id="119730149"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27856" checksum="5C6BA4931F8B1A98" modified="2023-02-22" version="1">MTLFRVKSDPGLFRVTDSTILHDLFKRMTQCCKSLALMYIRHRKRAKEPYHCKSFSPSFSRLARMKVYMCLLLLMVVGCTLIFAETDDVLECNEAGPFGMEDGRIPDASITASSYSTSYPPREGRLNFDDGSWRSGWCNADRRELQPWIQVDLGCDGIITSVITQGMRGYSSTVISYRVAYSDDGREWTVLTNNGSVVYLRGSYNNDTAVTNTLPRAIRARFLRIYPRGYYVGICMRFEVVGCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5W5</accession>
    <name>A0A914A5W5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058894.1">
        <property type="nucleotide sequence ID" value="XM_038202966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5W5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202966.1">
        <property type="protein sequence ID" value="XP_038058894.1"/>
        <property type="gene ID" value="LOC119730179"/>
    </dbReference>
    <dbReference type="GeneID" id="119730179"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="292" mass="31153" checksum="D0AC83F6084AEC1A" modified="2023-02-22" version="1">MATTNAPPAYVAVPQPVGQQQLVTVQPAAGVTLSTVNPQLRSGNWKGILWTGIIQVVFGSLTVILGIATVTAFDSFYSTSDIGSPIWCGILFYVVAGILGIVSGWKKNSGVAVGYMVMSILACLATCCVIGAGAARMSAINQVCHPIYTRYRYSYTYSYPRQIVSYYDYPPSFCYLQAAINGVYATLILLALAEFVVAIIGASMTCGPLCSGGSATQTVIQYQAQPHMVIATQPQGPAFYNFAGQPQVAYPAQQGQYPQAQAPPTAYPAQQGQYPQAQAPPTGEQQYQELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A675</accession>
    <name>A0A914A675_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058906.1">
        <property type="nucleotide sequence ID" value="XM_038202978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A675"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202978.1">
        <property type="protein sequence ID" value="XP_038058906.1"/>
        <property type="gene ID" value="LOC119730193"/>
    </dbReference>
    <dbReference type="GeneID" id="119730193"/>
    <dbReference type="OMA" id="SEEDMHC"/>
    <dbReference type="OrthoDB" id="10011855at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19725">
        <property type="entry name" value="bHLH_TS_OLIG2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000031">
        <property type="entry name" value="Oligodendrocyte transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF164">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="36640" checksum="229AEBE1222BFD19" modified="2023-02-22" version="1">MLLSHERAQEMSASTANTPPPPNGFPVRAVSSCSPAGSDSGAEFSDDSMSVDSTAVPCTGPPSPPLQSSDRREEDQEELGDYENWSSQAGGKITHQKHLGEIRSTSRNSHSSRKPPLQTKLLSEEDMHCLRLKINSRERKRMHDLNTALDGLREVMPYAHGPSVRKLSKIATLLLAKNYILMLSTSVEDMRRLLGEMYQGVHPPPPPQSMSLGHQSGPLPPTPTRPYFPTSPTPIVPKSLLLSTPLCSTSVSTRHEKASLSPTNSSGFRTYTGTSQERPGLATLPAPPTNSSTLGLYNGWPLPCSCAQCKTNPAGSCVAAQHRLPGVSAFSAAELIRPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8M4</accession>
    <name>A0A914A8M4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059759.1">
        <property type="nucleotide sequence ID" value="XM_038203831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8M4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203831.1">
        <property type="protein sequence ID" value="XP_038059759.1"/>
        <property type="gene ID" value="LOC119730800"/>
    </dbReference>
    <dbReference type="GeneID" id="119730800"/>
    <dbReference type="OMA" id="DTWILAT"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="265"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="626" mass="71782" checksum="C8D20AB477D7DAF6" modified="2023-02-22" version="1">MATGGTAEVLGKIGERHLECSICSTRFNAPKFLDCLHTFCFNCLQNLRQGEDPQGVKLKCPLCRRETILGKNGVEDLPTNLTLSALVEEFTVQEQLLKGQGSEIKCQSCDEQKHASSFCVECCHFLCQDCYRAHERLAITKSHKTYTMAQLQSGEVAYKSKLRKEPKCDKHVDQNLNVYCKTCETLICTTCSVLKHEKHSRTEISKTFEECKQKIAKLMTEGEEKKATLSNAHVCIVKSRQKLDSMFEATIEKISQKADKEVARIRKMEQGTRETEQKLKKEAEEIYEDRVQRFETTINSNKEQIKEVEQTLDEVYKIMKEEIQTQILDLQAKLFQNLKELIKKQSKTVPEKLHFIDFQERDEKTLGRLFLKDEWRLEKQMAYETNSVAGFSNEVVTVERYQGKLVSHVPTSNPQSPFLFRKLEIPDLRRPQQVAVNRLDQLIIINGRVVKTFNREYQLLHQFQLESGFNHRPTCLAVDDNNQIAVGYQVMQEISLHRSYGTLLKKLPAPGISDQLAISNQHLIYIKLYEGKMVALDYNGNKAFEVDVKGPKSVCCDSQGNIYILVSTPHIDQQNIKIFSPDGQKMGYLPVSNTDDLPRYALCMAFTPSGDLVIGTYDMLRIFQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8P1</accession>
    <name>A0A914A8P1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060133.1">
        <property type="nucleotide sequence ID" value="XM_038204205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8P1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204205.1">
        <property type="protein sequence ID" value="XP_038060133.1"/>
        <property type="gene ID" value="LOC119731156"/>
    </dbReference>
    <dbReference type="GeneID" id="119731156"/>
    <dbReference type="OMA" id="WLSMESN"/>
    <dbReference type="OrthoDB" id="347083at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000073">
        <property type="entry name" value="Adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF216">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="313"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="477"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="822" mass="90465" checksum="5EF64A5E0DE31788" modified="2023-02-22" version="1">NNISDFVIAFTSVVESTTEAQTTPQSTTSASVTTKTSTTISQSTTQKSATSLKTDVPSTDPRSTTTASSTDLQSTTSVYSTDPRSTTPASSTDLQSTTSVYSTDPRSTAHAPSTDVQSTTSAHSTDVQSTAQSPNAPATDTVSTNEQTTADLSHSTEQPTTAPQWTDTWADLPTSSFHPMTSSLTPSTTAENSRCFVGHIEFDCLPESTTVEDIKNRTSEEQLPLHDLLALMTWIADHDVIPAGVANVTDYADTYVDNVDNLLDDRFVETWDTAQAVPDFATNLVQSSQNLLEDLARKAPSEYQHVRKANNLEYEVLKSTNISEYSFKSRSSDDESSSTSITLEKQTIDNLMLQGNDNLSFTTLLTRKGNLIHERLSRRQPASHVIVHSLQVSGQIVSVPVTLQLKLLQERKPNEEPVCAFLDESKRSGEWSTVGCYVDKNKDTSSSISCKCNHTTSFAVLMQLQDFEISEADEKALEVLTYLLCGLSIMGLMTTLSVFMALRSLLKSERVTIHMNLSVALIVAHFLLLVSGMAAKQQVVCRIVAILMHYFFLAVFCWMLVEGAHLYFQIVRVFSNGMDKKKTYMVIGWGTPSVVVIISAASRWDDYVNYDSCWLSMESNVIWAFVGPALAIIMVNVIVLVMVVRIIVTSAAANKDKEYDHVKAGLKGSLFLLPILGLTWVFGVLSMDPNTLVFQYLFVIFNALQGVFIFLIYCAFNSEVRSAIQRSREKRALTRGDAISKASTAENYGYPLKGGWGKRNRVDVSTTCSSGEPQGQQMATLKIQTKTTTHITTHMILTPASDGSYLTPTNVKFAAWKLDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA22</accession>
    <name>A0A914AA22_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060613.1">
        <property type="nucleotide sequence ID" value="XM_038204685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204685.1">
        <property type="protein sequence ID" value="XP_038060613.1"/>
        <property type="gene ID" value="LOC119731512"/>
    </dbReference>
    <dbReference type="GeneID" id="119731512"/>
    <dbReference type="OMA" id="QNKMMTR"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF143">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="758" mass="85099" checksum="0B89EFE8831102F5" modified="2023-02-22" version="1">MILLVVLIVTSCQADMMNDTQLICYLEDLITSDEWTHLEPTITIADTTEVRVEDSRDPVEVLGQFKSVQPVSIGERDLLTFLGTAQADFITRIDSAVADDLVDQVIHRLHPAADALVCGKSSQRYRTPDGSCNNLKHPSWGMANLPLGRFLPSAYDDGKKSPRRSSDGHELPSARKVSISVTDEDGELVASRYSALNVHFGQLLSHDLDLVPQVAGKCSNCKKSDICLPILIPPSDPVFVDQKCINFVRSLGAPSRYGDQPWACQQTNRLASYLDASFVYGSSSATMSSLRIPGDPQGLMRVTPNPSSSKMDLLPPDNDIPNCAGQDGPISCGKAGDSRAAETVGLTSLHTVWLREHNRIARQLSRINPHWDGQTIFSEARKIVGAEWQHIVYNEYLPLLLGRRFARQHRLDVNLETRPEYEYNGDVDATIRNGFATAALRLGHSQIPTTIWRVDQNFERVFSDLQLKETFFNATHIYDAQGGGPDSILRGMLVQPLNKVDHFFSSAVRKHLFEDPKQGFGLDLVALNIQRGRDHGLPGYVRFRAEVCGLSLITAWEELEGVLPPGIARRLRDIYSSVDDIDPFVGFFAELPCPGALVGPTLACLLGKQFSYLKQGDRFWYENTEGQQAFTHDQLEEIQQASMARVLCDNTDDMLQIQPYAFLMAESLRVYRRCRFRGWLARRKGIRTRCRVAGSGSRPGGYWAAQRSEYEHESFVEYSKYYRYPNRNGRLKGFSNRWASCLDETRIPKMNLNAWAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAF2</accession>
    <name>A0A914AAF2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiesterase delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060748.1">
        <property type="nucleotide sequence ID" value="XM_038204820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204820.1">
        <property type="protein sequence ID" value="XP_038060748.1"/>
        <property type="gene ID" value="LOC119731616"/>
    </dbReference>
    <dbReference type="GeneID" id="119731616"/>
    <dbReference type="CTD" id="5147"/>
    <dbReference type="OMA" id="STNTWQN"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000002">
        <property type="entry name" value="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017287">
        <property type="entry name" value="Rhodop-sen_GMP-Pdiesterase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037825">
        <property type="entry name" value="GMP-Pdiesterase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="6">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="17050" checksum="F213100907DC0C6B" modified="2023-02-22" version="1">MPTRAEQIMGGFKLNWMNLRDAESGKILWQGSEDLSQPEKEHEARVPKKILKCKAVSREINFSSQEKMEKFRLEQRVLFKGKCLEEWYFDFGFVIPNSTNTWQSLIEAAPESQMMPANVLSGSVIIETKFYDDDLLVSTSKARLYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAX4</accession>
    <name>A0A914AAX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060524.1">
        <property type="nucleotide sequence ID" value="XM_038204596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204596.1">
        <property type="protein sequence ID" value="XP_038060524.1"/>
        <property type="gene ID" value="LOC119731426"/>
    </dbReference>
    <dbReference type="GeneID" id="119731426"/>
    <dbReference type="OMA" id="CNAGARD"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="151" mass="16676" checksum="6B953DBA532FBDA3" modified="2023-02-22" version="1">MVQAAPGDDLTALRNKAFASFRTQCCGKQVTGGATAWCNAGARDTNPWIQVDFSCSVVITGVITQGRGNRNRNQWVTEFKVAFSDDGQEWTDVTNNGSSTPMKFPGNSDQNTHVTTTFPKAFQARFLRILPTQWSSHCCMRFEVLGCTINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABM9</accession>
    <name>A0A914ABM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanine nucleotide-binding protein G(I) subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061257.1">
        <property type="nucleotide sequence ID" value="XM_038205329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABM9"/>
    <dbReference type="SMR" id="A0A914ABM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205329.1">
        <property type="protein sequence ID" value="XP_038061257.1"/>
        <property type="gene ID" value="LOC119731987"/>
    </dbReference>
    <dbReference type="GeneID" id="119731987"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002487">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003559">
        <property type="entry name" value="Guanine nucleotide-binding protein G(i) subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40043" checksum="E242F5BB911B05E1" modified="2023-02-22" version="1">MGCATSAEDKAAAERSKAIDRNLRIDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEEGYSEEDCKQYKPVVYSNTIQSMIAIIRAMGSLKVDFGDGDRTDDARQLFALAGQAEEGELSPELAAVMKRLWADGGVQGCFSRSREYQLNDSASYYLNALDRLAAPGYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKITKSPLTICFPEYTGSNTYEEAAAYIQMQFEDLNKRKDQKEIYTHFTCATDTNNIQFVFDAVTDVIIKNNLKDCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABZ8</accession>
    <name>A0A914ABZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alpha-2,8-sialyltransferase 8B-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060864.1">
        <property type="nucleotide sequence ID" value="XM_038204936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204936.1">
        <property type="protein sequence ID" value="XP_038060864.1"/>
        <property type="gene ID" value="LOC119731714"/>
    </dbReference>
    <dbReference type="GeneID" id="119731714"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF52">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2, 8-SIALYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="175"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45218" checksum="39040EE6ECB89BC9" modified="2023-02-22" version="1">MLGMHQPARPRVGRSSFWWFTAVCLFSVLGLMASIYITEDGHVLLYNRLRLKVTDSHVYVTSASKTKPVKTVTTSLTTLLTTPTNNQTSQVTLHCKMVCSQSAGNFCVPLEFAIFVYKTDTPTDNMTFNLQNYNPVVHIARESNTSHESSVLEVERCNLEEHFPGVELIPRQPSCAVIGNSGILNNSSCGNFIDSHDFVIRANMGLIKGYEVDVGKTSSLNAFNTLLLSSYGSAMEKTKSKRKLHIRATFFDTIKTLKESILWYPKELYIGNGSFASGRNYRSVIDALRRKGFTGIRFAYSWKPVHVEKLWGLPLGGTLGLDIYTVARTFCSNITLFGFYPFHKDLEGRAVKYHYYDKRKLDFDRSKWHNFSMEHTILKELERQGKLTLVVRDCKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC48</accession>
    <name>A0A914AC48_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060914.1">
        <property type="nucleotide sequence ID" value="XM_038204986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062270.1">
        <property type="nucleotide sequence ID" value="XM_038206342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC48"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204986.1">
        <property type="protein sequence ID" value="XP_038060914.1"/>
        <property type="gene ID" value="LOC119731745"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206342.1">
        <property type="protein sequence ID" value="XP_038062270.1"/>
        <property type="gene ID" value="LOC119732700"/>
    </dbReference>
    <dbReference type="GeneID" id="119731745"/>
    <dbReference type="GeneID" id="119732700"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF88">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045020551" description="Glutathione peroxidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="234" mass="25995" checksum="4A81C5A0E08EA6BE" modified="2026-01-28" version="3">MLALTGLALALLALPGVLGQESRCAANATHSIHDFTLTTIDGAKQITLSDYKGKIVIVINVASFCGLVFQYPLLNALREEYPDDLEILAFPCNQFRLQEPGSNSEIMPLLQHVRPGGGYVPNFPMFEKLEVNGESEHALYTRLKSVCPPVKIDIGDPEQMFWSPIRVGDITWNFQKFLIDAEGVPYKRYNPSVIPDQLKDDIELLITMRDMATSPPEPEDKTTQSSGAAAPKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACF7</accession>
    <name>A0A914ACF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 23 member 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061413.1">
        <property type="nucleotide sequence ID" value="XM_038205485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205485.1">
        <property type="protein sequence ID" value="XP_038061413.1"/>
        <property type="gene ID" value="LOC119732097"/>
    </dbReference>
    <dbReference type="GeneID" id="119732097"/>
    <dbReference type="OMA" id="NVSAYCR"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="75400" checksum="A285AA567C43EC43" modified="2023-02-22" version="1">MDNAGICGKARGLWCAQITFACLLVNTSVRNKSIRHGYDAMEVEMADINLQTNAEDLDDKNISEDDGKRFLEKTAMAVDTDHVKAETGTRRARPLHDLVYGLEDMPPWYTTILLGLQHFMTNFGSNVSTAFILAPYLCISHDPATMAKIIGTLFFITGVVTVLQTTIGVRLPIIQGTTFAFLVPTFSILRIRGECPPAPTENSTMAEIDAAEEEWLSRIREIQGAIMVASCVQVIIGATGIVGILLNCIGPLTITTTISLIGLSLHKAAADKAGTHWGIAVMTIVLIILFSQYISEIGVPTLSYNSRRKCHVTRFKLFKLFPLILGVAVSWLFCAVFTATDVFPDDPSVYGYAARTDLNSMVLERAPWFRFPYPGQWGTPTVTLSGVLGITAGVFASIVESIGDYYACARMSGAPAPPQHAINRGIMIEGIGCILAGAWGSGNGTTSHSENIGAIGLTKVGSRVVVQAAGCIMIVTGLIGKISAVFATIPEPVVGGVLCITFGMVTAVGLSNLQFVDLNSSRNLFVLGFSTLMGLIVPYYFEENPGLIKTGSVEFDQIVTVMFTTGMFVGGFLAIILDNTIPGTDEERGLLSWRDNVTGDTQDSSYEDESAENEAETDEDVEKNYLGLTVMNGGSDGVVPITNRPTETALPPCYDLPLVTRFIRRWAWCRYLPVSPTFQGFKFGWITKSCKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACG2</accession>
    <name>A0A914ACG2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061418.1">
        <property type="nucleotide sequence ID" value="XM_038205490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205490.1">
        <property type="protein sequence ID" value="XP_038061418.1"/>
        <property type="gene ID" value="LOC119732103"/>
    </dbReference>
    <dbReference type="GeneID" id="119732103"/>
    <dbReference type="OMA" id="CMADFWK"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824161" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="96" mass="10532" checksum="4230E28F76B5A0A5" modified="2023-02-22" version="1">MYASPLLRLIVLSLCALLVVSQLDIGDSDLTDTEGASIGFMGLLNRARPQYLKILQEGLSKRAQAEMNGASNAAKRRSRKDKCMADFWKGRGLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACR6</accession>
    <name>A0A914ACR6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061632.1">
        <property type="nucleotide sequence ID" value="XM_038205704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205704.1">
        <property type="protein sequence ID" value="XP_038061632.1"/>
        <property type="gene ID" value="LOC119732257"/>
    </dbReference>
    <dbReference type="GeneID" id="119732257"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="261" mass="29127" checksum="5927AECCF114631B" modified="2023-02-22" version="1">MFEAKMLQSSVLKKIIESLKDLFADANFDCSSSGITLQDMDSSHVALCYLKLRSDEEGFEDYRCDRNITLGVNLGLMSKILKCAGNDDVVTLRAEDEPNILTFIFDSKNSERVSKYDIKLMEIDSELLGIPDTDYSCVVKMPSHEFQRICSNLSQLGDSVTIDCHKEGVDFKVAGEQGSGAIKLKQTTSVDKEEDQVTVQLNEPVTQSFALKFLCAFTKATSLSDTVNLSLTQDTPVVVEYPIAQHGYLRFYLAPKIEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACW7</accession>
    <name>A0A914ACW7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061765.1">
        <property type="nucleotide sequence ID" value="XM_038205837.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061766.1">
        <property type="nucleotide sequence ID" value="XM_038205838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACW7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205837.1">
        <property type="protein sequence ID" value="XP_038061765.1"/>
        <property type="gene ID" value="LOC119732378"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205838.1">
        <property type="protein sequence ID" value="XP_038061766.1"/>
        <property type="gene ID" value="LOC119732378"/>
    </dbReference>
    <dbReference type="GeneID" id="119732378"/>
    <dbReference type="OMA" id="DCTQVKC"/>
    <dbReference type="OrthoDB" id="10050052at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="214" mass="22226" checksum="23DC014113575C95" modified="2023-02-22" version="1">MDRGASRGKNCYNCGKLGHISRECPTPGSGGGGGDYGGDQTCYKCGKPGHISRNCNNTGSTYSNSADKDCYNCGEVGHLSRDCPNKSSGGGGGGGGGSYNKDCYTCGRKGHISRDCPNASGGNKCFNCGMAGHIRADCQEPSKSGGGSGVVCYKCGKEGHFARDCSSGGNSDDKETTCYRCHAVGHIARDCPDDDKKCYRCGKGGHFARDCDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD03</accession>
    <name>A0A914AD03_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061712.1">
        <property type="nucleotide sequence ID" value="XM_038205784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205784.1">
        <property type="protein sequence ID" value="XP_038061712.1"/>
        <property type="gene ID" value="LOC119732325"/>
    </dbReference>
    <dbReference type="GeneID" id="119732325"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="225" mass="24883" checksum="B82E6BCD03E5324A" modified="2023-02-22" version="1">MEQLLGDNTLRPAILKQLFMQRLPTNIQLILALITQVVEVSPSPAQACAAVPAPALVAAVKPSAASEIELLQALVERLTAQMELLVRQNQYQHGRSRSRSRNQSQHRRDRSSFASGDNPTDSCWYHWKPGQSSCTARSHATTYALPQFQHGPGKPAGQRIGATSSTGTPNQCCLFHVYDKITGSKFLVDTRAEVSILPPTPRDKQRCRSDFVLEAVKTQIHTCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD95</accession>
    <name>A0A914AD95_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061713.1">
        <property type="nucleotide sequence ID" value="XM_038205785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD95"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205785.1">
        <property type="protein sequence ID" value="XP_038061713.1"/>
        <property type="gene ID" value="LOC119732326"/>
    </dbReference>
    <dbReference type="GeneID" id="119732326"/>
    <dbReference type="OMA" id="MISTECT"/>
    <dbReference type="OrthoDB" id="6373546at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="195"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="483" mass="55349" checksum="1A3AD11A9D82CDD9" modified="2023-02-22" version="1">MIHQKPLTSAPPRLQRMLMRLQPYNFTLQYRPGKEVPVADSLSRSPTTDGTHIPLDIQINLVHFTADRLAAVKRETERDPILQELKQIIISGWPDRMKDLPAPLRPYWSFRDELAIADGILMKGCCVVIPTAMHTYTLNKLHEGHQVATKTKLRAKDTVYWLNMNQDIDHVVSQCPTCQEHQRSQTKETLLPHELPTRPWQILGTDLFHFEGNEYLMIADYYSKFPLVHRMPANCTSGAVIDATQQIFSEHGVPEKIISDNGPHFASAAYKVFADEWGFTHVTSSPHFPQSNGFVERMIQTVKRTMTKARACGQNISMALLCLRTTPVDSKLPSPAELLCGRKVQSNLPVVIQNTSEHKDQTYQRLQDRQAQQKAYQDRSAHDLKPLHPGQLVRVQDPRTGLWTPAQIKQRCEEPRSYVIVTPNGRELRRNRRHLRDIEPAKKRVTFEDDTSPSRNREVQDTPKTPTITRSGRQVKPPKRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEN5</accession>
    <name>A0A914AEN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062232.1">
        <property type="nucleotide sequence ID" value="XM_038206304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206304.1">
        <property type="protein sequence ID" value="XP_038062232.1"/>
        <property type="gene ID" value="LOC119732669"/>
    </dbReference>
    <dbReference type="GeneID" id="119732669"/>
    <dbReference type="OMA" id="SKSCKML"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123309" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38029" checksum="3BACB64295491B80" modified="2023-02-22" version="1">MAKLNAGLKVCNLMVLLEVVILVSGHQFHTRQQLMYAAENRALQGFAYATKTLRSRVICARECSMDERCKSFNFNDCNKMCELNLATRREHPEDFNATQGSAYFDADEDTPLYSLTDSSFNRSKSCKMLLDAGYCSNGIYTIYPEGFGNGSLRVYCDMETDGGGWIVFQRRQDGSVDFYRNWAEYQSGFGDLSGEFWLGNDNLVTLTSDDSSGTWELRVDLEDWENNTAWAKYSDFQISPGEYNLNIGQYDASSTAGDSLGYHRGRPFSTKDSGSNCAHVFTGAWWFYGCFISHLNGPYHPFGSVQFSTGVQWVTWKGYYYSLKTCSMKMRELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGA0</accession>
    <name>A0A914AGA0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062748.1">
        <property type="nucleotide sequence ID" value="XM_038206820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206820.1">
        <property type="protein sequence ID" value="XP_038062748.1"/>
        <property type="gene ID" value="LOC119733233"/>
    </dbReference>
    <dbReference type="GeneID" id="119733233"/>
    <dbReference type="OMA" id="KPRENTH"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="635" mass="70744" checksum="A8F7A99751E1CE9B" modified="2023-02-22" version="1">MAAALQNISSHLNCGICRDRYTQPKILDCVHSFCQKCLEQYYTSRYAGQPKIPCPVCRRETVLPETRIQGLKANFHLMGIVEEVSLQEKVACSENTKAICEICDEGNEAMHRCLDCAQNICPNCRKTHLRCTATSNHTVATLEDIRQGKVTVKKAPEEDESKCHKHKGEVKRFYCETCEELICRDCTVVNHSKPKHHYIESGEASLKYKQSLKDMFQNFTKGIKILQKALATSSQAKQQFTQNVTKTVKAVKDKADKMRAEISTQETKMIAEIKQLQPDRNRTYDEHQSTLTMMLESKQHSLGTSQDIINTASDNDFLSLYPIISKDLKSLKSQNPPQIDPKLSYLSFTPGQRIGDINLGKLEVEAVKWEMCREFGKKGSGPGEFGFARGITATQPGEIAVADRINNRVVICSNEGQHKGTIPLQGPVAVAAIRNPEQRLLVLEEGSKYVKVFNMKDNTLVKQFPTVPKHQVDKTEIELMSLAVTKNSILVGDTDNMVWTEHKPTDGEILHTIPVQTPPCYLAVDDNTDRVVVSGYNTGKVVVGDSKGRKICTINPTINGEPVGYCQGVCCDSSGIYLAVRQGVIGTGHIHHYDLDGRFLDCLAQGLYSPRGITFTSQGQLAVADDNSIKMYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI47</accession>
    <name>A0A914AI47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063392.1">
        <property type="nucleotide sequence ID" value="XM_038207464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207464.1">
        <property type="protein sequence ID" value="XP_038063392.1"/>
        <property type="gene ID" value="LOC119734097"/>
    </dbReference>
    <dbReference type="GeneID" id="119734097"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="52"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="466" mass="49746" checksum="0D1CAFD096F2CCF9" modified="2023-02-22" version="1">MYISCPCPPGTPSKTFEQESQPPRTLFLHQNSPWTMSGVVSNSLEGPDGGRPGWVAVLALWTRNLMVTGITKGLGIMLPILQIQLTSQMWIIGWIASLTTATSGLVAPFGGLVSRRFGAGYVMMTCGVMMSAAAIAGSFVENSLQLALLYTLLAGTAIGISNVVAKEAVGRCFTKNYATANGIAQTGSSVGLIVFAPLVQLFLDTYGWRGTMLLVGAITMHSVASGAVMVATRQPELDQSNAYQTLPQTEHTNSSSAHESTLRSHCGSLWKFVSKNFEVGLLLNSRYWLVAVISCCNIYAYLMWIVYFVSQAQSNGFTLEEAGSFVTIAGVANLFGTISQGPITDRGVMSSWTLVAVCLVMSSVSYLASSLLTSFWPMMTSAVLILFSDGVLSCQMDVLVKQVLGVELLAGAFGWIGLKVTLLLVALGFLPGLVYDLTGSYTAAFLLIGSVQAVPLVPLLILRYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIJ7</accession>
    <name>A0A914AIJ7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063552.1">
        <property type="nucleotide sequence ID" value="XM_038207624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIJ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207624.1">
        <property type="protein sequence ID" value="XP_038063552.1"/>
        <property type="gene ID" value="LOC119734249"/>
    </dbReference>
    <dbReference type="GeneID" id="119734249"/>
    <dbReference type="OMA" id="LHWIYND"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="266" mass="28961" checksum="1F0FF995EF5B9AA0" modified="2023-02-22" version="1">MSCAATQNNRALAAIVGCLVSDAAAQPLHWIYNLGKLDAIVGSNKNSLEFWEPSKNPFYRIETGRGTAYADQTTALLESLVACEGFDKADYGERLQAVFGPGTDYENNLNKVYVMKSGVQSKYPIHGPWSPKAIKDFLANRAEGKEKTGSEVMCDMHAVVAVTPVVAMYAGRSDMLEKVEQSIAVVTVVEEAIVVGLAAARILEQFILNPGIDGDAALEAVVKDLASPSRNNPNDLDRAVIGQLKKVLEKRSWNHREAAKKFFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL87</accession>
    <name>A0A914AL87_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064338.1">
        <property type="nucleotide sequence ID" value="XM_038208410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208410.1">
        <property type="protein sequence ID" value="XP_038064338.1"/>
        <property type="gene ID" value="LOC119734832"/>
    </dbReference>
    <dbReference type="GeneID" id="119734832"/>
    <dbReference type="OMA" id="NICCAQD"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="35663" checksum="C8F3565337E21450" modified="2023-02-22" version="1">MPHCASPTPHAFGPVLVCFLAVILVLSALPRFASCSSSSTSGWLASDFPDPRVNPPGDCGFTSGEFAWVTPAADPANATNWVCDPDRVLSLDEALSLANYLNSLSHQSPCDCEAVECPGSDVTPTGYLIGVALVDRLNIEGMTFEPLNVKAANFAKATRAKWFSGLGCDDNALVFYSRFSNELYISIGETVEGVVSDLELASLYRLGEQYLTVDDSSSSSQRGAGDEGQTTPSSSAVTHDGLVAVVSNLNEAILNGPSISSDIIFAFSIPLLLLVVLTVMCLVSNICCAQDISVPEPSVSRRSRTEVDAKSENEEDAKSENEEDAKSENEEETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALM4</accession>
    <name>A0A914ALM4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064910.1">
        <property type="nucleotide sequence ID" value="XM_038208982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208982.1">
        <property type="protein sequence ID" value="XP_038064910.1"/>
        <property type="gene ID" value="LOC119735283"/>
    </dbReference>
    <dbReference type="GeneID" id="119735283"/>
    <dbReference type="OMA" id="ANIRRCT"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="350" mass="39439" checksum="4B7FF3758D6FFFAE" modified="2023-02-22" version="1">MATALQSAFERISENHECSVCRGILRQPKLLHCAHTFCKSCLQQCHNWGNNGALNSKMLCPVCRQETVLPRSGVEGLKTNFELQSLLEEIFQLEIPSSNSSWQEGVKPSSCKTHKGEMLKLYCETCQTLACDICAGADHSDPEHVMIDTDTASKKYRESLKGLFPAFGQDIKYMKANIRRCTTIDKEYLNKIAEIRKVVQDKASEAIAKVRSEETRLLDEIKSHEEDHTERMHEQKRAVKRLLTRKQRSLKLAKDFAREAGDEEFLSFYPASCKGMKKLQDEHLQKPMGLHSVPVLLGSQGIATGANLGNVVVKDVWELHRELGKKGNGDPANTSRCHNVVQSCENVVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMP2</accession>
    <name>A0A914AMP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064863.1">
        <property type="nucleotide sequence ID" value="XM_038208935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208935.1">
        <property type="protein sequence ID" value="XP_038064863.1"/>
        <property type="gene ID" value="LOC119735230"/>
    </dbReference>
    <dbReference type="GeneID" id="119735230"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="519"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="92889" checksum="6EDC96CEBF0DA693" modified="2023-02-22" version="1">MDPSIFFLSFLPDDYDPHPWWLLDLGSNHNLSRINVTLRKDLGGVRFIGAIARAGLSPNFTENLPCGSPATSEQCKNGAVISFLCEPPRTARYVSLDIDTSMPGVVATRAYLQLAEVTVENVTSGEGAALHVYGKSTSQSSTWDAHPAYKAIDGWTYTYTHTDDYDPHPWWLLDLGTKHCLGRINVILRTDLGGFRFIGAIARAGLSPKFAENLPCGSPATSQQSREGARIPFLCEPPRLARYVSLDINTSMPSVDATRAYLQLAEVEVEEYTSGECAVSQGVCSNDIGPPTNGDHTITNPRSLSYNLINYTFFGTRVDFSCDPGYTLHGASSIECIETGYNNVTWSDSVPTCEDYVCINPNPCQNGGTCIREITGDLYNCSCPAGFSGGDCQTDDPCMPNPCQNGGQCMPQGNTHECTCQNGATGNNCQNANANTTTINIVVVIVVGVVLIVVLVIVVVCFVKRSRRRRRGGRPPAVDRGRGQELIQKKLSNVYWIDTHQASTSEFSGPAKEFPRDKLHILGQLGSGSFAVVFKAEAEGIIRRGTNTTVAVKMLKECATPNDQSDFKKELRLYSMLDRHPNVLSMLGYCNDKDPMYIILEYVPHGDLQTYLRHIRTGTEPFYLKKEEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHRDLATRNILLGQGLVCKVSDFGLAREVAEKSQYEMKSQGKVPVRWMAPESLLSNIYTSKSDVWSFGVLLWELVTLGSHPYPGMSSQKVIDEIKHGYRLPKPEHCSDDIYQIMKDCWQEKPEDRPDFAGLHTTIDDILADAAGYLEMGNLNTDDYVYLKPGQGSKSTTHSLTCSPTGSIESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP06</accession>
    <name>A0A914AP06_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065760.1">
        <property type="nucleotide sequence ID" value="XM_038209832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209832.1">
        <property type="protein sequence ID" value="XP_038065760.1"/>
        <property type="gene ID" value="LOC119735888"/>
    </dbReference>
    <dbReference type="GeneID" id="119735888"/>
    <dbReference type="OMA" id="RISEFMG"/>
    <dbReference type="OrthoDB" id="10059291at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40614" checksum="D89655FCFBC2037F" modified="2023-02-22" version="1">MLKNEKLAEIKASPYFALLCDETTDVTVLEQLIVHITYLDCVERETKVTFLEINEIANCTSDVIKDKLVEVLRRTGLDFRSKMAGFGSDGASTMVGRINGVAAQLKRESSTIISNHCVAHRLALAVGGASGKVDYVKKFNNTLEILYHFYEKSSVRTAALKEIQDSLHVPSSRPKRPRTTRWLSHDQACDTLSKTLPAVMVSLRREGSERGDPKAIGLSLLVEDWRFVACFYMMLDILPQLSILSKSFQENSLDFEIIQKQVAMTVEILEARLVRPGPNFHKMQQGTVLEAVKQKIPDFTPNIKEGDLEKFKENYFFRMSKGVGILRLVATGRNLEALELFALFGAPLTLRNDECVEDCCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQM8</accession>
    <name>A0A914AQM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Thromboxane-A synthase</fullName>
            <ecNumber evidence="8">4.2.1.152</ecNumber>
            <ecNumber evidence="30">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="33">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="34">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 35">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="8"/>
    <dbReference type="EC" id="5.3.99.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_038065744.1">
        <property type="nucleotide sequence ID" value="XM_038209816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209816.1">
        <property type="protein sequence ID" value="XP_038065744.1"/>
        <property type="gene ID" value="LOC119735872"/>
    </dbReference>
    <dbReference type="GeneID" id="119735872"/>
    <dbReference type="OMA" id="VGMYEIR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="23" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 34 35" id="KW-0349">Heme</keyword>
    <keyword evidence="20 34 35" id="KW-0408">Iron</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="25" id="KW-0456">Lyase</keyword>
    <keyword evidence="22 36" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 34 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0492">Microsome</keyword>
    <keyword evidence="35" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="19 35" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 36" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 36" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="36">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="34">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="515" mass="58260" checksum="A70A8C75B50B13FC" modified="2023-02-22" version="1">MEVVGLDLSPFTLTLLLIVGLVFLSLCYDWWCHQYFQRRGVPVADYIPIFGSSYKFSEGFHLAMEDFVKEKGKVVGMYEFRRPILLINDPDVIKKVLVKNFNHFCNRRVFPLLIPPLTRGLSMLANEEWKDVRNILSPTFSAVKMKKMSVLINECCERLVSGFDRAQEGGTPVECRELFGGYTLDVIARCGFGLQVNVQDKDDPFVNNAKKVFDFGNANPGVALAMVFPPLVPLLKWMNVTIVDQSAIDYLKEVAEEALKMRKEGEGTSKNIDLLQLMLNAHNDTELDQGDVDSVVKSKGKGTRQHKPLSNEDVQAQAITFFTAGMETTSTLLSLTAYLLAMNQDIQEKLHAEIDNLAPTGDSLGYDVIPKMEYLDMVISESLRLYPPAVFLERLCNETIRLDEFTVEKGLCVFVSIWALHYSPEYWQNPAKFDPERFSAENKANIKPCTYMPFGFGPRNCIAMRFALLETKMALVHVMQKFRFDVCSKTEIPPTLSKYGFISPKSVLLSAVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARS8</accession>
    <name>A0A914ARS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hepatocyte growth factor receptor</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">HGF/SF receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Proto-oncogene c-Met</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Scatter factor receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tyrosine-protein kinase Met</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038066353.1">
        <property type="nucleotide sequence ID" value="XM_038210425.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210425.1">
        <property type="protein sequence ID" value="XP_038066353.1"/>
        <property type="gene ID" value="LOC119736406"/>
    </dbReference>
    <dbReference type="GeneID" id="119736406"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000131">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000868">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1271"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="24">
        <location>
            <begin position="37"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="1366"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1703" mass="187892" checksum="B4E9784BD19D7FBD" modified="2023-02-22" version="1">MHFHLNHPRELNIMESSRRHSALLWAIALSWSVICINVFITSAEWHGDLSDYELASFDNPDILDENERRASKFNHFALSYHGDVYVGAVNWLYRLDSRLEEIQNVSTCDASRPDSVMPCHLTNNYNKILVVDSTRPNSLITCGGVYDGVCQLRQLQDISNVMMESVPYVAGFEDASTVSLVAPGTNGQEMLYVAVTYTGENVNNHGDFPTINRRNLETIRYHQNSLLSARREGSIFFNGPAKRTIFSFKYVAAFTHSGFTYFVASQKEDLNSAQFVTKMSRVCQGGPDLDAYTEITLQCSGSDDSVYSLVQAAHFGPAGPDLAASLGLHADEQVLYAVFAKNQGATGTSDVPRDHSALCVYRMTDILDAFREAVRGCIQVGNTYSVDYLESSFCSSFGIDILDRYFCIPVTPDIQRHPLFKYAKGIDPVPSTAILELPGTLMSSIITTIEANHTIALIGTSRGDLLKVHMESNTAGRLYERISLDTSPVLPDVKVDDRTRVLFLLTEQKLVKLRVENCGQYTTCETCIGTEAGNDGDPYCGWCTLERRCTRYSDCWSPDVSTRWLAYNAAQCINITDVAPYDNLPLTVTEQQITLTVQQLPDLGTGQIYECHFGSFQSPATKNGEVLECTSRPSDWIPAIPQGDDAVRVDLGVESSETSVQFIDTDFYFYECSTHTSCVSCVGSRWACDWCVFENRCTHESSTCTPANEIIITGDNNPTASAVKGPEFCPQLLNQTAEILLPNNIMRSITVMTTNLPDEAEISSYQCSLDVEGSPQAVNAERNGDMITCQEKAYTYQSNDEPEMEVGLSVSWTDTSGVAHILDDIHGFDVTLYKCEVQKPDCSRCVTSRPVLECVWCGAMPSDSGVCTLNKVCRENRVTLDNGLNCPDPVLTEVFPLTGPIEGNTVIDVIGTDIGRRSSDVVRVMVGNQPCDLAGLNSDYQTGASVSCRTRAESKGAELVTLTVTGADGTMQHSSGTVNFNFTDPRITVFQPSLGPEAGGTVVSVNGSALNTGRDIEAFIGDTSCPIKGQPVQSMLECTTTADQRGYKGVVKLSFDGAMRTSSDMYTYTENPTITEVSPLKSIVSGGRMLTVTGTFLNTSRNRQIVVTNANEVRNECQGESATEMRCPSPNITDLDISNDNLTFGFIMDGVTQLLTWSEDNGVDLEYFEDPMYNTFEGGMKEKEGETLTITGERIDSAITEGEIIVTIGVESCPVSLITETLLVCELPEEAPAAGDFLGEDTAAGLPVVWVRHNNLKFRLGYLVYPSTVPLVAILVPSLVIPLSMAILLAATFVYCKQLQRKRTHDRRLLGRIVAIHLEIDSHVKRRRWYRSQKQSESAQPKQKRIVLNNKVSFVPDDIHIDFSQLELGETLGQGAFGRVLKAVLHDTSGEDQIVAVKTVQDTSDPKNVVKFLEEGLIMKTFDHVNVLGLLGLTFDADKNPLVVIPFMANGDLKTYLVKKKQTLATSLLMKFASHAALGMSYLAQHKFVHRDLAARNCMVNSDLLVKIADFGLSRDMHESDYYTSGDAQAKLPIKWMAPESMERRVYNARTDVWSYGVLLWEIFSKGAKPYPGIPNQDVYDFLKRGQRMDAPKNCPPEIYGIMVRCWQDNPKSRCTFVQVANELEELLEGDRDYVAAPSAGVVGKRPNKHREELGVTDDSYLVPMQQETAFGADGPCSDGETSGSHSTAAHDPLDYVNKIVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASX0</accession>
    <name>A0A914ASX0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066758.1">
        <property type="nucleotide sequence ID" value="XM_038210830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210830.1">
        <property type="protein sequence ID" value="XP_038066758.1"/>
        <property type="gene ID" value="LOC119736820"/>
    </dbReference>
    <dbReference type="GeneID" id="119736820"/>
    <dbReference type="OMA" id="CYSTERE"/>
    <dbReference type="OrthoDB" id="6783748at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="28434" checksum="12D0BDD796A7A321" modified="2023-02-22" version="1">MDLRIGRTACPVRAVIAKVKTKGILGMDFLLPTGGTLDFNKCELLLHGEHIRCTTRWGTTLHARVVVAETTVIPPGHEALVQGRVTRDFESGDLGIIEPIEGGGELAQKGLILARTLVDPKEGVLALRLLNPGSRECMVRSGGTTAGRLTPVVERDVLQAHAFEPGDENKDVHVPGHLEDLWKRSVENLDPCYHYAVARLLTDFADVFSEGDHDIGRNDWVKHHIDTGETRPVRQRPRRQPLCKQQEIDRQVQETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUE8</accession>
    <name>A0A914AUE8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038067283.1">
        <property type="nucleotide sequence ID" value="XM_038211355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211355.1">
        <property type="protein sequence ID" value="XP_038067283.1"/>
        <property type="gene ID" value="LOC119737181"/>
    </dbReference>
    <dbReference type="GeneID" id="119737181"/>
    <dbReference type="OMA" id="FPQFHIK"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000094">
        <property type="entry name" value="MAP kinase-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000001">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="43340" checksum="7549E30A13892AC1" modified="2023-02-22" version="1">MDAFSWLRDKAKGKNNNRQQNMMGESQSTQSGLSYTPKKHAITEDYEITKKVLGLGINGKVLECHNKQSGHKYALKVLLENQKAQREVDLHVRACKNYNIVGIEDVYENIYNGHRCLLVVMECMEGGELFSRIQEKSLFTEREAAEIVRNIGLAIQHLHAMNIAHRDLKPENLLYKDKSKNTVLKLTDFGFAKMTTTATLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNHGLAISPGMKRRIRNGQYEFPKPEWDKVSQEAKSLINQLLKTEPADRLTITEFMNHTWVRKYNEVPETPLCSVQVMKEEKDQWEDLNDEMTNALATMRVDYDQIKIKDMSDASNPLLMKRRVQKEQPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVR0</accession>
    <name>A0A914AVR0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067847.1">
        <property type="nucleotide sequence ID" value="XM_038211919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211919.1">
        <property type="protein sequence ID" value="XP_038067847.1"/>
        <property type="gene ID" value="LOC119737505"/>
    </dbReference>
    <dbReference type="GeneID" id="119737505"/>
    <dbReference type="CTD" id="11338"/>
    <dbReference type="OMA" id="FIWQRPG"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="462" mass="51758" checksum="63F326E8FB25ED2C" modified="2023-02-22" version="1">MPGPDDDDRKNSDRRKRSRSREGRRSRSRSHSRERRRRSRSRSRDRDRKARRSRSPVAHRRRRKPHKYWDVPPVGFEHITPQEYKAMQGCPDAVQAAGTGPVPPIPSLQAMPVVPTPVMMPTPAAAMPIVANQMTRQARRLYVGNIPFGVTEVRLRDQMVDFFNNKMQELRLSTNPGKPVLAVQVNHDKNFAFLEFRSVDETTQAMAFDGIMYQNQCLKIRRPKDYQPMPGVAETPSLHVPGVVSTVVQDSPHKIFIGGLPNYLTDDQVKELLSSFGVLKAFNLVKDSATSMSKGYAFCEYVKTEVTDQAIEGLNGMQLGEKKLIVQRASVGAKNPSAQAMAAQTVQLNIPGLNLPGTAGPQTEILCLMNMVTADDLKDDDEYEDIVDDVRDECGKYGNVRSIEIPRPIEGLDVPGCGKIFVEFSNLMESQAAQQGLSGRKFANRVVVTSFFDPGAYHRRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYX8</accession>
    <name>A0A914AYX8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068466.1">
        <property type="nucleotide sequence ID" value="XM_038212538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212538.1">
        <property type="protein sequence ID" value="XP_038068466.1"/>
        <property type="gene ID" value="LOC119737892"/>
    </dbReference>
    <dbReference type="GeneID" id="119737892"/>
    <dbReference type="OMA" id="CRTVSNT"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49996" checksum="D122A3F5C0F5F6A2" modified="2023-02-22" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGVDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRMMCTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDESYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATLFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKIAVCDIPPRGLKMSATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEEGEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZE2</accession>
    <name>A0A914AZE2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069038.1">
        <property type="nucleotide sequence ID" value="XM_038213110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213110.1">
        <property type="protein sequence ID" value="XP_038069038.1"/>
        <property type="gene ID" value="LOC119738273"/>
    </dbReference>
    <dbReference type="GeneID" id="119738273"/>
    <dbReference type="OMA" id="RICTLMI"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="167"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="393" mass="44968" checksum="68B5E3A9C8D72A6B" modified="2023-02-22" version="1">MRLYGNPSFFCQQGLEKLNDFVTKWYFRSSNFGTDALKQMFKIRKGHQVMGSGWISSALLTALIAIVVSSVSARICTLMIDLDLRGCGQRMGRFVLPQGDPCTCTGVRLGGHYHRYAPEMQGQDPPLYMDMLPEVTAEVIGRWFNCTESKLEESTLGVMTPVFSTTPEPSMPPADCQEILEAGQNTSGVYTIRHKRQNMQVYCRMESGKGYIVFQRRMDGSVSFNRTWQEYAEGFGDLTGEFWLGNQKVHILTYNGGRELVITLRAFDGDEARIRYGYFKIIPSEYNYLLRIGDFIEESGDAGNSLGIHRYEDFSTPDKDHDKTNWENCAEKFHGGWWYSRCGSYTSRDFKSNLNGLYYNNAAVDDYMGMQWVTWKGKNISLKGCEMMIRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0L8</accession>
    <name>A0A914B0L8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069537.1">
        <property type="nucleotide sequence ID" value="XM_038213609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069538.1">
        <property type="nucleotide sequence ID" value="XM_038213610.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213609.1">
        <property type="protein sequence ID" value="XP_038069537.1"/>
        <property type="gene ID" value="LOC119738687"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213610.1">
        <property type="protein sequence ID" value="XP_038069538.1"/>
        <property type="gene ID" value="LOC119738687"/>
    </dbReference>
    <dbReference type="GeneID" id="119738687"/>
    <dbReference type="OMA" id="ICHRKER"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1468"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2073"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2143"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2371"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2412"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2453"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1511"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2156"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2419"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2459"/>
            <end position="2475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2512" mass="279323" checksum="C71400B8847EFE0E" modified="2023-02-22" version="1">MIKLGEHRNLPTNLRRPAASSHSGDSTNSSRRKAPADESVLPAKNPALQSQQQAVSLFAETNRDNLQIATRSEIPEQCSASKKASKSTSAADPSFRTKHSSASLEEFKENSLPPSTVSVDDQLSYSSSLYVHDNAVTCNGSAAFTPTVPVVNSDPASTFLPADGSEVMMPVQPVHINIHSVPIYHFVPRQLDLGVSSAAPGTVSRETVSEHDNITTPCLPEAQMPSLHWDEASEPDSVAQSKQMPGNPSTNKRSSTPSSFTKIPPKKTMTKSLQYQCPKCLQRFDRIMAQLQHKCCPERTGGGSLLNRPPLKLFKCLECCEEFSDLESKIRHKCSAQKEGLFSLRGSETNSSCHGGKTGTQAKMRKKGSQNLPRRRRNTFIGEKYGLEAESKKKSGATGHVEKRKNITMKIKLPQIAVKESMSSGPVYYKQFKCGLCSMKYRTVGHLKNHINSHYGSDEYKRNRLPYVCRICKAGFRYSKALKKHAAAKCNGKKKSGGKEQINQSSEMIKESSKKRPFEEVNAEASKTTSIQDNSSSSGPRSEVSRSQLQSPQTDQSSPSKSPHKCGFCGITWDSATTLRKHVRSHWNQIFEKPSNPLICSRCNEEFDNCVKLFLHVRRSGCTTASEDTSQSDEGEPRNEVRTQAAVDKPANSNSGRPEVTACQTRNKGKYSCPHCGLTFWRSEILNVHLQSSHPLLLDQAEFPVENAEKSSPDRNNEKFVEPAVDPVVHTQPLEPVLSNQDLSVTDLDSDSCMRTGIYPCRCNNCNLDFSTWKQLNAHRRTHHPLSVIHLKLGMNQQGGPDESLDEASVDIMEDDFIHSCDLCSRVFRHWRSLALHKKAKHHVKVMFARYSGPNKQPNQEATDVLSSSRTIQQMSTFTSDSVDMEQVPNLVETQENSNALIYHSIEAEATTKKSTNLCKDVSTSPPCDVLPQQPISGINFARGCAISQGSQYFELPGRVEPSTDEDLSLRSSSNPLCEPRLTVEDLKISSVVSLFAGGGQTTDDMQWQRSKTGLKLSVDSVPSEKISEEVPFNVEARIPMSTINVLEVPQTSPLDKIIPSMPTGQGQHVTPDAFNLIVDSVLGMEFPSHPNIFETVTVVGPSSDAISNALSYSEQGWHGTMKKITFSEAKNILRVLEKNSISNCYHCSVCGEWFDGIPHYTSHILAHCDMEKYCCSFCGRIDLNIFAMLDHVISVHCEPNGPTSNQDQSTLMDTRKQSSVDESEVTDLCETSDPESSLDHQKPDANFPRSGCDYVFEPSRLESHLGRNAKSDLYECPLCLFKIKKKSGLMYHLRIHHELHPYRCRYCQQRLSFIPDVQVHFLQSNCQTMLGSQQQAGHQQAGHQQAGTTLGNQVSPSDRETSHQETNSSILGCQSFGTARCGDDHSVPSGHTGCGDPALISSQNSIEVSGELTANTSRWTPCDTVTEEQHRTSDISLKAGSPATKEDLQPIDKDGENLLTTVRVKEERLSDDEAESPNCMMEGNTTSRVKTELPDECDYKGAEWVDQPDGDFRGFEDQPEDNPKTEGNQLDISSDIPCQMPNNILPRSTSSKSFVREMLQKDDPVDEAEVAVSDVMTAEKEHGVAILISQSEGVSELDIVKDCNKNGLKHRDVEDTEEEISHSADHGFEKGAADISNSNALSEICEVTEEPESACGGSDEVLTEDSKIDNAGRVGASMESPVMSSNTVPEDNPISHAQPLDELFRLASDIGIIVTGLNLKDSTSYENSTSQKISPESIQNDVHRTTEGDERSNVGSVTNPNNAHAAEMVLSNHVVSSQGLQTASDSCKLQECASPVGNGRKEIDGDQNIESHVHIQEEHENQLSPSFQKKRSLELHTDSQDTLKRQKIENPQNISMKNNIASDITIVDSCKESGCVDLTNTETSGGPVSTQAQEEQIADNLFLDMDIGEDKIMSDTLKRITKNCFTSRILESFEKDSVAPVVTQNTFNLDLINGPPFVSRGKRAITDTEEKEDAPISEEKQDDPYVYIEHTMDDDDGMSGMPKIFDVAGNGQMPVVPCRNNDSPPFTSPYPDVLFNRASVTKDVDNRGGKTNSYASLEGPVTDVVYSGTSEPAQPCYPMNEGISSAHRSPDERRSDVLLRTMLDYPMGHSQSLNQPRLQIPSPEDHLRKGFVDAQSRRASLSGNQEAQKCPSIGHHTQQSRRNQNQWGRRYSREGTRNQYLKTDAVSPKNIGQDNQNHCLPGSRWSLACSFPDSRVQESRHWSSTMLRTNNQTDSYQYQELYHDSHQRRAPMHSPQEYRQEHFLTSHNHVGALRRENEASMACITRQTEASAAFSHQNVDSREWCWTNNNEQGLRTRVENSSMDNRGLEPSANQYHSIPWQQLDDRSSNHRMTRCSRSYSTLDCQLVSPDADIRQVPPNRPETVHVYQSDGRAPMNAESRDDAYRKLWQRHLRKQHSDPSSSSSTNPGSGYKYQRMGQPITAQRREYMETRQIDEPQQVASHSVQQQRGYSSRTWYPPSHPEENASGGFPQIVSISSLHPHYRYLNRTHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0M7</accession>
    <name>A0A914B0M7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069945.1">
        <property type="nucleotide sequence ID" value="XM_038214017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214017.1">
        <property type="protein sequence ID" value="XP_038069945.1"/>
        <property type="gene ID" value="LOC119739185"/>
    </dbReference>
    <dbReference type="GeneID" id="119739185"/>
    <dbReference type="OMA" id="HDNGRME"/>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433002" description="CUB domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="407" mass="44730" checksum="9B30F51B4E7A6202" modified="2023-02-22" version="1">MAWFVVLLAVLLVQCGSAVLLESYEPAYIQDANPSFMCLAKNVSDISGRVYSHLDVERAPYAPNMDCLFTINTQPGRRINLRFDFFDLAPGFDRASNRCRSDADRFMVYESDKDFVIKNDILQPEVTYCGGTGKFPKDYQSYGNIVTIRFLTDGLSSPDAGVKLVYTSYKPPQEGSDDCFRCVDDSMCIDEELTCNGVPNCNDDSDEADALCREELSNFLEIIIEKLGVGVVATIGAAIGLLILIIFITCIVCCCCCKKGGEDDQKQYRTPPTPRPGSYPSHNSNYSSYSSSASTTNGGMHPMPGLHSRMYEGLHGMNGGGSINGSINGMNGVGSLPDHHRHHHHHGPPQPCHPYPHQHSMNGLNRTPYPNYPPTYPSLPSGGSLQNGGYSVAYNHDNGRMEFPHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B145</accession>
    <name>A0A914B145_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FYVE, RhoGEF and PH domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069221.1">
        <property type="nucleotide sequence ID" value="XM_038213293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B145"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213293.1">
        <property type="protein sequence ID" value="XP_038069221.1"/>
        <property type="gene ID" value="LOC119738406"/>
    </dbReference>
    <dbReference type="GeneID" id="119738406"/>
    <dbReference type="OMA" id="WITALNK"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15743">
        <property type="entry name" value="FYVE_FGD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF267">
        <property type="entry name" value="PROTEIN CBG10230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="723"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="943"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1278" mass="141771" checksum="2A52C495C67A92EB" modified="2023-02-22" version="1">MASCNGWLTNHRRRNSLFLGGTGAGLERGTSAPTSPAKKPAIAPKPSSLKSPPLPRKQSHGVNKSPVPTPKPRKLQATQSSPVSVGAGGTGGPSPIKTKTFQAAGSGQRANSEDSGVFDLRDSAELSKTELNIASEVQDSILEEPALADEKLQDVCYEEAPTAGEPDSPDISPKRCPPKPLPRRAPPSPVPPPRRAKSVIDAPILNRALKPKLNRSTDDLSTCPLEEEPEDEANDTNDSDASHSPLKLPESKQDRTTCPISENDRFKLNATPPPIPPHKQGSPSRTPQTNQKALKPARPPPPSKSIPAGPPVRPKPLSKKTPGQESRHPIVGSSRTDGSEASPKIPPRSRRSLITDDMLLVDQTEKRFFPENGFPVEPEPPPRLSSNLPPDDGNGNEAPQLKIPPRKRWSQHSNSSLTAMPYHKVQSSPDPASPRSPEVILHPSGIVGYHSVAPPRPVDGPPKRLAPVPPPPYSTTLQQLRPVPEGSERRKPPPRPPPMRSALPPKPSSLIKSISQEQDTSDNSSDLQDSPQHQESSNTTVQSEDKNPADRTSIISDDDEYVLPDGEYDPTDGPYYENNDFGPVFEPPRSPPHSPSAESSATKRQVPGRQKRVPPPKPKRTPSIQSDISNDGYEDMSKGSFASVALSSIGAEVYSVPRSCEHSMHESGRCQCADYAEQSSGGEDDGSSDEDEDSYEKFDQGVMAEKEDDEDAGVDPEVRKRRKAFLVAQELRDSEKVFVDVLKLINEDFKAAIEEAEKTAGRPIIEKGMLDQILGHLPQLQMLNEDLLADLNSRVNNWSENPRIADIFLKKGPYLKLYNTYIRDFQKLTATLEEACLKSPLFSATLKEFEASPRCRSLSLRQHMLKPIQRIPQYKLLLTEYLKQLDEETQEEDFKDTMAALNIVSEVANHVNESMKQGDNLDKLLQLQQSLVGNHELVRPGRVFIKEGDLLKLSRKVPQTRRFYLLSDILLYTTPFLLTPGQYNYKLHNVLSLAGMRVSKPAQEDYKNEFSIISVQRSFTLASNTPEERDSWITALNKAITEYASKRSSFAMLHPQFAQLLSDGDTTSLGRKAPAWIPDARVTMCMICTCEFTITWRRHHCRACGKVICGNCSSNKLPLLYLANKVARVCDQCYRNLKGDKQSEDTEDGKERGKGKNKRKRSTKLVIRPSALKQVSASEQDTTMSGYLMLRRKKDWKRQWYVLKEKVLYRYKASEDVAALESMPLLGYDIQLLNEPFEGVEPGLILQLCHQSKLCQLRAENKAMAEKWATLMTEATHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1J1</accession>
    <name>A0A914B1J1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069862.1">
        <property type="nucleotide sequence ID" value="XM_038213934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1J1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213934.1">
        <property type="protein sequence ID" value="XP_038069862.1"/>
        <property type="gene ID" value="LOC119739102"/>
    </dbReference>
    <dbReference type="GeneID" id="119739102"/>
    <dbReference type="OrthoDB" id="10034530at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121856" checksum="768ACF8DC90DD6DA" modified="2023-02-22" version="1">MVDQLKQVKQPDILLPHLNSLLFKHLIVVALPLGFAESGQSLLFAIPLISTLPGYTKISSQTPNDATVAITNGYCDCNPCQNDGTCWTLQDGSYQCLCTFGYEGEQCQNELYPDADYSTLHEVPLIDLFNVLSYENPRENPFYQLAAYYNTLETKFAANLLGSGAEIIEGRIGQYYRLIGAHSWLNPVFNAPGVTCVEQGLAGCDRGLAVSLWVLLEQEALKEEETVLFYSGTNVDEAESPHLGIFIDANKRMKFQVNDGDHVWTVTVSSSSLPLGSWCNLAMTWRPASDLHAYINSYKVGTLDVVPSQRQSTTVPPPSSSPWVVTLGSRGQRSTTSPMAVSDLVIWDRFLYDFERHRFLGVTADELQVLHGADYLWTTDGYLRRDQVALLSQHGIAATGPIAYSSKPAQVPGRDDKGWAMNVDGVSDQWLALGDFADTCVSDPSLCPDGITFALWVKVHRPVSVGDTSFAFIFSTGGQSSRGCALYQHGGNRLRATVADGRREWIVEVKFVSNDDHWVHLAISWRQSLGLVLYIDGNTHGRDRTGHVRLRHHDLDSRLLVGRRNDYLAGFANVTLEWLAIWEHYIEPWEARREMGLVENDQYATATYYWNQQRFISSTFDILANSGGTEGPSGDVTVPYADVVDLSSPGAYLNLGDFMGRCVTDPTKCSTGLSVSLWLRYQHGIKSSKPSIIIRTRDLNGKDQPGFVMFVLDAVLWLGVQSSPGRWFASLEVEHFPNDIWTNVAFTWSEARNLVLYINGFQFTGRINYRFEPKSISPNPTPQLIVGATSTPTPSHPVTFQVHSLAIWESYIERWNINQLLGMSKSELYCFKYGDYCWSFEPTLRLRHPFELSPAGATFTSDRRDQGTALCTDGRSGWISLGDFSAQCPARPSACEHGFIVAMWVKLTEVTSHRRSGYLLSVGAEEQGESGLSLFQSITGIRAKVVDDNLSWETNIKSSWLTFDRWIYLTIKWTGQILVIDIGGEELPTTTHIYASSFHGANTHFKDNTPLMTLGKSIHDNRGFLAACYDDVLLLLPKRAGEDLPYQNSSVQENENQFKLDEPGPETAREECKIIHEADCATTIEELLYVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5A1</accession>
    <name>A0A914B5A1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071124.1">
        <property type="nucleotide sequence ID" value="XM_038215196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5A1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215196.1">
        <property type="protein sequence ID" value="XP_038071124.1"/>
        <property type="gene ID" value="LOC119740010"/>
    </dbReference>
    <dbReference type="GeneID" id="119740010"/>
    <dbReference type="OMA" id="TEVDTHR"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15865">
        <property type="entry name" value="SNARE_SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="225" mass="25514" checksum="7CAB78EEE20BF776" modified="2023-02-22" version="1">MAADLAEVRNVAKEIIAYDLKINGLIQEIRSNCRSIHDMNQVNQKIKEQMKTTQNRIQDLERIANEQDKETDRLDILKDVGNFRKQLASTQTSIRKANLSCKMAIDRQERESLLQGGTDPDLRKRMNKESLAQTAGNITDNLMSLNRMMAANVAQSNLANEVLGKSSATLSDTHEEFKGMGGVIQTSRSLLTKYNRRELTDRLLIFLAVALFLATVLYILKKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5X0</accession>
    <name>A0A914B5X0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071631.1">
        <property type="nucleotide sequence ID" value="XM_038215703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5X0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215703.1">
        <property type="protein sequence ID" value="XP_038071631.1"/>
        <property type="gene ID" value="LOC119740409"/>
    </dbReference>
    <dbReference type="GeneID" id="119740409"/>
    <dbReference type="OMA" id="STYHYWA"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037562404" description="Glycosyl hydrolase family 13 catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="38"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="625" mass="71076" checksum="362027A439D78ECF" modified="2023-02-22" version="1">MARVSLATCVAVLLLVSTPPVAVGFESNEWWKGTIVYQIYPRSFMDSDGDGVGDLAGITSRLEYFNDIGVGTVWLSPVYKSPMADFGYDVADFKDIDPIFGTMADFDALIAKAHRLGLKLMMDFVPNHSSDQHQWFLDSKKNKDSTNEYKDYYVWEDPKQGCSDPPQQCVPNNWVSVFGGSMWEWVPERQQFYLHQFLVEQPDLNYRKPEVKTAMDDVVRFWLTKGVDGLRVDAIRHMYESEGLEDEPVNPDYTPKPGEQAQYDSLLHTMTADLPELHDVIKDWRDIFQEFSTDQYRFMVTETYDTHKALLPYYGTPERPEADYPFNFGLIELNKENLSGTKIHQLVDDWMKDLPHDKWPNWVIGNHDNFRIADKIGLEYARALNVLNLLLPGTPTTYYGEEIAMEDIWVSYNDTQDPFAINNPEHWEEYTRDPERSPMQWDRSSHAGFSTTAGKTWLPVNQNYLSGINVADQKADNTSALALYKKLAALRKDEPAFQTNHLKYVIVNDKIFSFLRMPDDQDTKPDSFLVIINAGTSESTDDYTAALTKLELKAEGDAGVIKVSSNMDRNGKSQGLSKISSAAGEALIIKASVYGFSSASVPTLSLTLSIATVMVKIFYHVMFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B709</accession>
    <name>A0A914B709_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071242.1">
        <property type="nucleotide sequence ID" value="XM_038215314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B709"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215314.1">
        <property type="protein sequence ID" value="XP_038071242.1"/>
        <property type="gene ID" value="LOC119740114"/>
    </dbReference>
    <dbReference type="GeneID" id="119740114"/>
    <dbReference type="OMA" id="EPRRESC"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="151"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="510" mass="56752" checksum="69026021A5982168" modified="2023-02-22" version="1">MCSRLQIQASTHPGCHWASYRRKYFPIWVISQIRQGIELAFKMDQATAGVLVCIIALQGLLFVAVVAVLLAKYYRVNLVLKSYYEIMLLIRIRAMHRVNKASNGQQLEPTGPTLGTSAANVQQPHPEPQTIVLDDGISIAADDVQIKFSQLQMEDELGQGAFGTVYRAVFNNWSAGERSIVAVKTVEDADPSRIVQFLKEGLLMKSFNHPNVLKLLGLTFDRSGQPLIVLPFMANGDLKSFLVKQKQNLSHTQLTMFAYHVALGMEYLEEQQFVHRDLAARNCLVDDKLVAKIADFGLSRDLDESDYYTSGEKQAKLPIKWMAPESMERKVYNTKTDVWSYGVLLWELFSRGRTPYPDIHNRDVHSYLRQGKRMNPPRFCPTKISAIMRHCWLDSAKKRWSFGQIVQELEPLVTHGNAQGIAPSCAKPVHGPCSLNVPGVPPQMVSGSAISGKDRSPSAACRGLQGASAGGSGRVDDRFSMEVLKSGVGKPDGGDYRREADCYQQSSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B711</accession>
    <name>A0A914B711_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic solute transporter alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071744.1">
        <property type="nucleotide sequence ID" value="XM_038215816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B711"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215816.1">
        <property type="protein sequence ID" value="XP_038071744.1"/>
        <property type="gene ID" value="LOC119740494"/>
    </dbReference>
    <dbReference type="GeneID" id="119740494"/>
    <dbReference type="OMA" id="WPVFCIV"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42444" checksum="E55C9C36BDA7F944" modified="2023-02-22" version="1">MEEVFNETEYYKVFNCTSDPTAAEMFTFFEHNPAGLVCLIIATVITAVQTVIMIDGIVWISKNIPHAERSSSMIWLYSIWPVFCIVSLCGLYIPKAALLSNAGANLFLFPTIYNYLALLVDYFGGEDAMISKMKDHPIKYSRPPCCCCCCCCPPGMCSRVLKRKQFNRLELLVMQISVVRPLLLFLSEMFVLDGTFPVDNPFNYMAPGLYIQILTVGSTLTAMQVLGTLNASCRPHLKQYSTQSKFLIVQFALLMCNVQNTLINFILNGLGGCGNPYPYKSRDYIWNCFLIILESLIFQPICIKYLRTLKGNVLFIPQKLKKSKTYAGTSLMKAGQKGLLEEATEAADLDGASEKTPLVMRRARSHSDIKEGYGSVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B835</accession>
    <name>A0A914B835_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Repulsive guidance molecule A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071597.1">
        <property type="nucleotide sequence ID" value="XM_038215669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B835"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215669.1">
        <property type="protein sequence ID" value="XP_038071597.1"/>
        <property type="gene ID" value="LOC119740390"/>
    </dbReference>
    <dbReference type="GeneID" id="119740390"/>
    <dbReference type="OMA" id="DLHYHST"/>
    <dbReference type="OrthoDB" id="10013795at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF6">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="11">
        <location>
            <begin position="81"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="10">
        <location>
            <begin position="194"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52830" checksum="ECC1F59216372A96" modified="2023-02-22" version="1">MPLYFRTNRVNRASISSSSSSTAAAAVVVARPSEPGEAAATWMVMGRGQRFHRASPAQATAVILYVLLIVAMLISTVSSECKLKKCSQRYSQKLSENVRRNPNRRYCQALVDYKKCVMDIPPRSCRGELNYHSTLSIIPDLMEQNNCEAILAEAEATTTPLPSGATPPARRGTAVPPPAPEFYDTCDYHGERSYKSCSLFGDPHLRTFDGYFQTCRVAGAWPVFYNKYVAAQVTNVQLLHGSGATATTKLSVIIKGHHECADRKLYLAQTGNLPGAFVDGTKSSGPGGRGVVVYEIVPDKHVEIHIRYIGTVIIIRQIGEYLLFSVRMPEEIIKRQGPEDLQLCVRGCPGREKIDYVEFLKQTKDVDKEKLQSAIAKCRKTNVIDVYLDSCVFDLLTTSDDNFTNAAENALRDISRLQPNASLSLHNRTSVFEDNKILAALPPRRNSAPPRTRSSITAYTHFAIVLLALWASHRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8N2</accession>
    <name>A0A914B8N2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="6">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038072543.1">
        <property type="nucleotide sequence ID" value="XM_038216615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8N2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216615.1">
        <property type="protein sequence ID" value="XP_038072543.1"/>
        <property type="gene ID" value="LOC119741029"/>
    </dbReference>
    <dbReference type="GeneID" id="119741029"/>
    <dbReference type="CTD" id="58478"/>
    <dbReference type="OMA" id="LQGMVWE"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000079">
        <property type="entry name" value="Enolase-phosphatase E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="334" mass="37528" checksum="74D7D0CC29991B88" modified="2023-02-22" version="1">MHCNIGKQKKGRVFYKRGNKLKTYRPRAMMLKHGAINSSMHDDCQSGSDSMMSQDSDKNTSKHPVNWLDLLQGIEVIVLDIEGTTTPITFVKDVLFPYVTEHLEDYLDDHWEEKKCQDDVRALRDQANLDKDLEGVVTIPEDIQGDSSSSKMSVKEAVMQSIRWLMAADRKVTALKQLQGHMWRSGYKDKTLVAQVYSDVLPAIKQWISDGKKVYIYSSGSVEAQKLLFGHTDNGSLLELFSGYFDTKIGSKVEKESYLKIAAEVGSEPGQILFLTDVTREALPASQAGLKTAIVVRDGNAPLTEDETKSYQQIKSFSELLPDDGEPLEKIQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8V5</accession>
    <name>A0A914B8V5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072265.1">
        <property type="nucleotide sequence ID" value="XM_038216337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8V5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216337.1">
        <property type="protein sequence ID" value="XP_038072265.1"/>
        <property type="gene ID" value="LOC119740880"/>
    </dbReference>
    <dbReference type="GeneID" id="119740880"/>
    <dbReference type="OMA" id="DVQNCMA"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="94" mass="11113" checksum="2657305D3AD3DDCC" modified="2023-02-22" version="1">MSVHVPEHLKHNWSQSKKKDKDEGEGAEQEDEEEEEDDPVDAMLKKAGCLKLHHDVQNCMAEHRDWRQCQKEVAKFRECVSRNVQRTQKKQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B932</accession>
    <name>A0A914B932_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072688.1">
        <property type="nucleotide sequence ID" value="XM_038216760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B932"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216760.1">
        <property type="protein sequence ID" value="XP_038072688.1"/>
        <property type="gene ID" value="LOC119741091"/>
    </dbReference>
    <dbReference type="GeneID" id="119741091"/>
    <dbReference type="OMA" id="FQDVGWS"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13760">
        <property type="entry name" value="TGF_beta_BMP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732046" description="TGF-beta family profile domain-containing protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="302"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="428" mass="49055" checksum="FA9AB5980A7E015C" modified="2023-02-22" version="1">MVGVPTMSRPLMLVVCYLLLLLGCTYGGQVQGGTDQDSSTDTQGQSTPHRSREAVIRAFEKNLLNMFGLKEKPKPSRKIHVPQYMLDLYNAQTDSPISNLDIDVKGKTSRSTNIVRSFHHQEHEGDYTSSQDDSRQHGHTHRLTFNVSAIADNEVLTDAELRIFWKNHHSVSKRDLTDRDQTNSTKSSEQSYKHRVNVYQILKRLVKSNDVIKRLIDTKVVDIRNTSWQSFDVRPAIKDWRRPHRPNHGIEVEVLDHRGRPISVHRNLRIARSVSEQVDSSEDETRWFQERPHIVTYTDDGRQKRSAIRRTSRQRSGKRKRKLKPNCRRHPLYVDFTDVGWNSWIVAPAGYQAYYCQGECPFPLVDHLNATNHAIVQTLVNSASPQLAPKACCVPTDLSAISMLYLDDSDSVILRNYQDMVVEGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9Q5</accession>
    <name>A0A914B9Q5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072913.1">
        <property type="nucleotide sequence ID" value="XM_038216985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9Q5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216985.1">
        <property type="protein sequence ID" value="XP_038072913.1"/>
        <property type="gene ID" value="LOC119741240"/>
    </dbReference>
    <dbReference type="GeneID" id="119741240"/>
    <dbReference type="OMA" id="GHEPYLT"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037736894" description="Peptidase M14 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="449" mass="50197" checksum="03E1883BD2003B59" modified="2023-02-22" version="1">MTSGTTISLFLIAILRAVCALPIVKFEYHNHAHLTSVMTSLTNKYPNTSHMYSIGKSVQGRDMWVMAVAGVKPNGRVIGRPEAKYVGNMHGNEAVGREVLLHLLEYLLKEYRRGNPEIKKLMDTTRIHILPSMNPDGFEVSKQKCRGLDLRANMNGYDLNRNFPDYFEPTIDPIQPETKAVVDWIYGNQFVLSANFHGGALVANFPYDTGQPGIGNAMETVYHQSPDDDVFRFLAKTYSKAHPRMHLIQENTCSPNTDTGFVDGITNGADWYSVAGGMQDFNYIFGGCMEITIEMSCCKYPAPSHLRLYWEENRLPMLEFLKQANRGVKGQVFNTDNQPIDGASVSIVELKSPHPLFTTRSGEYWKILLPGSYTLLVFKYGYATSNQKLTIPHDSPDAMVLNITLTSINPNIANVTDGTPSTAAAWIQTITTVVVTATFSLFYPNWIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDT2</accession>
    <name>A0A914BDT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074382.1">
        <property type="nucleotide sequence ID" value="XM_038218454.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074383.1">
        <property type="nucleotide sequence ID" value="XM_038218455.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074384.1">
        <property type="nucleotide sequence ID" value="XM_038218456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218454.1">
        <property type="protein sequence ID" value="XP_038074382.1"/>
        <property type="gene ID" value="LOC119742507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218455.1">
        <property type="protein sequence ID" value="XP_038074383.1"/>
        <property type="gene ID" value="LOC119742507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218456.1">
        <property type="protein sequence ID" value="XP_038074384.1"/>
        <property type="gene ID" value="LOC119742507"/>
    </dbReference>
    <dbReference type="GeneID" id="119742507"/>
    <dbReference type="OMA" id="DCSLCRR"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="143" mass="16075" checksum="1413762B019E1738" modified="2023-02-22" version="1">MDGELVRHLGGCHCGAVRFEIMAPRKVTVYNCNCSICTKKQNRHFIVPNFRFKLLQGEDNLTCYTYNTKAAQHTFCKTCGVQSFYTPRSHPDGKGVAPHCLDEGTLEGVTVVDFDGVHWTQNMAQNTGNIKEMSKENDKLSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFA1</accession>
    <name>A0A914BFA1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074933.1">
        <property type="nucleotide sequence ID" value="XM_038219005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219005.1">
        <property type="protein sequence ID" value="XP_038074933.1"/>
        <property type="gene ID" value="LOC119742823"/>
    </dbReference>
    <dbReference type="GeneID" id="119742823"/>
    <dbReference type="OrthoDB" id="546518at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="458" mass="51202" checksum="D3D38EFDF24DC92C" modified="2023-02-22" version="1">MAEGGVTNLVLDETQKELQECPICYTEYKDARMLDCSHSFCLKCLQELKLTQNKDDKSIVCPLCRSETALTEAGLDMLPEGSKDVNQQEQTEGQGLKVMCQACDEENEAISRCVDCKHYLCQECLKAHNRLASLRAHKIVDLTELPVESQDITEETELKKVPKCHEHPDQDLCLYSSGKILGEVNEVMTTATCYEILKSKKKILRDLNEQVEVHKSLDIKHGKSFLGFKESKEDGQLGTLLLEEKWEKCDTFSLSVFCATHLAAYSTSEMVMLCSEKLLTLDPEGKEISTKTYKPDPDKPNEPHDPNDIQKATALAINKDDQLLILDNPAVKIFNKEYQLLHQFLPGKEAGLDSTPTCLAVDSSNLIAVGYKDKDQISLHNPDGSLVRTLPAPMIDTYLKFSNKQLIYTNNKEGLLMAVDFHGNKLFNQSCSDPRGLCCDDTEGTVYQIKCAGGMQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFE8</accession>
    <name>A0A914BFE8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074978.1">
        <property type="nucleotide sequence ID" value="XM_038219050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219050.1">
        <property type="protein sequence ID" value="XP_038074978.1"/>
        <property type="gene ID" value="LOC119742849"/>
    </dbReference>
    <dbReference type="GeneID" id="119742849"/>
    <dbReference type="OMA" id="WCDCTTE"/>
    <dbReference type="OrthoDB" id="3686858at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="353"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="537"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="90798" checksum="1306DE07CADF7E3C" modified="2023-02-22" version="1">MGLPTTTELPTTTELSTTTELPTTTELPTTTELPTTTELPTTTELPTTTELPTTTDLPTTTELPTTTDLPDTTELPTTTELPTTTKLPTTTELPTSTELPTTTLFEWWCDCLSTTAELPIDPWWWCDCTTELSTTTELPTTTELPTTTELPTTTELPTTTELPTTTELPTTTDLPTTTELPTTTDLPDTTELPTTTELPTTTKLPTTTELPTSTELPTTTLFEWWCDCLSTTAELPIDPWWWCDCTTELPTTTELPTTTELPTTKRLWWWLQTTTGLPTTTGLPTTTELPTTTELPTTTELPTTTRLWWWLPTTTGLTTTELSTTAKRPTTPGLPTTAELQATTILTEPSEDADNVSPILICPSNAEVTLDAGVSSARVEWSPDLPSGSDNVDGIIDTVVCRDEGNALVVSGGVYAEGVTIVTCTARDSSGNEGTCRFTVIVQDADTGNNTAIIAVISVLSTLLVLVVTVFIVRYVKARIQLRTQNAEGVNSSDIEMNLTTVYEDKITPEGQTSTVYEDVGLPSWAGMWEILWSNLGVDDHVLGSGNFGEVRLGTVLVGGKKTRSAIKILKGQASASERADFMDEFRTMSSIGHHENVVSLLGACQHDDVLYVALEYLPNGDLQSYLRANFSTSNSKAALTSDQLVTFAVDVAKGMKHLAESGVIHRDLAARNVLLGEGLIAKVSDFGLSRGEDIYVQTSTRRVPTRWLAMESLRHQTYTTQSDVWSFGILLWEIATLGGTPYPDVKNARFLADLLKEGYRMSKPRNCDDEIYNMMILCWNDDPNKRPTFTDLVSILSKMDANKLEHTYMAVDPKTYENVVRLELDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH27</accession>
    <name>A0A914BH27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074737.1">
        <property type="nucleotide sequence ID" value="XM_038218809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218809.1">
        <property type="protein sequence ID" value="XP_038074737.1"/>
        <property type="gene ID" value="LOC119742659"/>
    </dbReference>
    <dbReference type="GeneID" id="119742659"/>
    <dbReference type="OMA" id="ACNTHAV"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041609" description="Retinol dehydrogenase 13" evidence="2">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23220" checksum="99B893BB38309F0B" modified="2023-02-22" version="1">MMINILYLFFQLEPVVLAGIGQQGKTEDGFDLMFGVNHFGPFLLTNLLLDLLKRSAPSRIINLTSLAHRFSPEFDFAEADETGAVRYPKLASYPISKMAVNLFTHELSRRLADTQVTVCSIHPGIVYTGAIDGLLRRGCLRKLLIPLFRLLMRTPDAGAQCVIHCAIDDSVKEHTGAYFVDCQPCNEAAMATDEALAKQLWEVSCQATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH81</accession>
    <name>A0A914BH81_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075623.1">
        <property type="nucleotide sequence ID" value="XM_038219695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219695.1">
        <property type="protein sequence ID" value="XP_038075623.1"/>
        <property type="gene ID" value="LOC119743292"/>
    </dbReference>
    <dbReference type="GeneID" id="119743292"/>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="125" mass="14078" checksum="C46D04D8C4F8864C" modified="2023-02-22" version="1">MTTPSTLPLLPPLTPMGVCKGAVCITAMALTATVGSVFMIGPILPLMAIRPRLFRWVADWMMNLWLLLPVALMELFMGVTIMTSGDTLQSDEGSIILMNHRTRLDWFFFWAVLHRQSTLRTEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHJ3</accession>
    <name>A0A914BHJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle assembly abnormal protein 6 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074899.1">
        <property type="nucleotide sequence ID" value="XM_038218971.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074901.1">
        <property type="nucleotide sequence ID" value="XM_038218973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074902.1">
        <property type="nucleotide sequence ID" value="XM_038218974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218971.1">
        <property type="protein sequence ID" value="XP_038074899.1"/>
        <property type="gene ID" value="LOC119742799"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218973.1">
        <property type="protein sequence ID" value="XP_038074901.1"/>
        <property type="gene ID" value="LOC119742799"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218974.1">
        <property type="protein sequence ID" value="XP_038074902.1"/>
        <property type="gene ID" value="LOC119742799"/>
    </dbReference>
    <dbReference type="GeneID" id="119742799"/>
    <dbReference type="OMA" id="HMAMKIK"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041513">
        <property type="entry name" value="SAS6_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18594">
        <property type="entry name" value="Sas6_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SAS-6 coiled-coil" evidence="9">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="71828" checksum="9EEDB7C205CEAB31" modified="2023-02-22" version="1">MSEPLFNSAVTVCIKCTGHDDRTSSVRVQLEIQTASSPLQRKELNVRLTDDADPFFLFNLMLGEDDFQSLKVQQGLLVDFTAFPQKLIELLQRCAEEQSKDAPKFVLQLIRSEPLSHGLAELCIVETNPFKHLTHLALKLQPGGDADVKKYLASCLKRLQGDHNNLSQRLKLTESTLSGQLQESQKALSARTRELESLRSEWSAHTDSLNAKHKQEIAEIKQNALQSQRDTEQRYEQEKKQMEDMRQQGSSELQSRLADLQTANKELTDRKYRLESSVRELKGKLTTLEEDYQRAQHELQALRQQRGSLESDQRSREQTLSQQQTRIAVMQQEVRDKEALLAKSNQLMESANEQKAKLEESIQHKNSLVGKLESTVKSTSQEVMKGNEIIKKLQGELKASLAKLKLKNTVTGKQEKLLEERNQTLRALQQDADGLKTKSQQLENENDRMKETLESTRTKLEESRQLLKTNENVINWLNKQVNEAQMSKRHGMFEVPTSTVAYRPQGVPAAVSSSRPWPMSSTHLTNTMSTIPQSTPMGYNSSTASAPSTSKRSEPALDPKYLQHPSQHHSQHPGQHPSQHPGQHPGQYPTASPRDGGPLQKSGPVPLQLSSTPMAPTAPAPSVPPLMSAYFPPQLKGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJZ6</accession>
    <name>A0A914BJZ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076130.1">
        <property type="nucleotide sequence ID" value="XM_038220202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076131.1">
        <property type="nucleotide sequence ID" value="XM_038220203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220202.1">
        <property type="protein sequence ID" value="XP_038076130.1"/>
        <property type="gene ID" value="LOC119744332"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220203.1">
        <property type="protein sequence ID" value="XP_038076131.1"/>
        <property type="gene ID" value="LOC119744332"/>
    </dbReference>
    <dbReference type="GeneID" id="119744332"/>
    <dbReference type="CTD" id="51496"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="6">
        <location>
            <begin position="305"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="488" mass="55596" checksum="8007F5CDE6A75F4F" modified="2023-02-22" version="1">MARRRRRVAKTKQQTRSAHTEPNEEGLSMGSKVTMIPTKGAEEHLRESRLPFSPSGLISSLKNLIWSTPVQKTDIPCKRKRELADDNPAFITSTPVPKPKRTKTEPPAVDECNNNTIPKNAMAAKSAQDYESPPRTTLLGTLFSPVYQFLCNGMTTENKENLPKVAERLDLDSVPADSMCQEAAVPRMPPSDAVATDAELSAGVASTAEGNTPRSDRDEDDEEEEEEEEEEEEESQEKTMTDSNHNDMTHCSLSACNTYVDDDGLDTDYTLDEWETFDPYYFIKQLPPVSKETLYRSPALPLKTRRAPEYSLVLDLDETLVHCSLAEMENCTMSFPVVFQDVTYQVYVRTRPYFHEFLERMSKLYEIILFTASKKVYADKLLNLLDPDKKLVRHRLFREHCICVQGNYIKDLTILGRDLTKTVIIDNSPQAFGYQLENGIPIESWFADDNDVELLKLVPFLESLVSMKEDVRPHVRDKFRLHELLPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLT9</accession>
    <name>A0A914BLT9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysine-specific histone demethylase</fullName>
            <ecNumber evidence="21">1.14.99.66</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:60244"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.99.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.66" evidence="21"/>
    <dbReference type="RefSeq" id="XP_038077079.1">
        <property type="nucleotide sequence ID" value="XM_038221151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLT9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221151.1">
        <property type="protein sequence ID" value="XP_038077079.1"/>
        <property type="gene ID" value="LOC119744934"/>
    </dbReference>
    <dbReference type="GeneID" id="119744934"/>
    <dbReference type="CTD" id="23028"/>
    <dbReference type="OMA" id="SSRGEMF"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043426">
        <property type="term" value="F:MRF binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000179">
        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000027">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000029">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.660.10:FF:000001">
        <property type="entry name" value="Lysine-specific histone demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000002">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017366">
        <property type="entry name" value="Hist_Lys-spec_deMease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038051">
        <property type="entry name" value="Histone_Lys-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 21" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 21 22" id="KW-0274">FAD</keyword>
    <keyword evidence="10 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0678">Repressor</keyword>
    <keyword evidence="18 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="16 21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SWIRM" evidence="24">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="798"/>
            <end position="799"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="836" mass="92222" checksum="DA69B59D2C46E766" modified="2023-02-22" version="1">MERKEKEKDNGGSGDEAKKRISPQSSDAGSSASGSSGSGPSVTLAANGGGGGGSGGHSHSISHGMHSHGHGHGHSQGSGSHVQKTFKIAPGMHDAPRRQSKRKRAKVEYREMDEKLANLSEDEYFSEEERQLKKEKVTKPAEDEPEESDLEEPKGLDGAAFSARLPSDKMTAQEAACFPDIIQSPAQTQKLFLYIRNRLLQLWFENPKLQLIFENALPQIEAPYNSDVQLVMRVHAYLERHGLINFGIYKRLKPLPTKTLGKVLIVGAGISGLAAASQLQTFGMDVTILEARDRVGGRVTTYRKNNYVADLGAMVVTGLGGNPMTIVSKQVNMELTKIKQKCPLFESGGQTVWTIPKDKDEMVEREFNRLLEATSFMSHQLDFNFIHGKPVSLGQALELVIKLQEKQVKEKKSDYLRTVIGLQEQTKENQAKLLVLQDKIKELHKQYKEVSESKTPRDITAEFLVRSKMRDLNAALKDYDVLVFNQKEVDEKMQELENNPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPIALSEGLDIKLNTIVRQIKTSNTGVEVVTQSAKGQSGTYTYKADAVVCTLPLGVLKQSPPVVQFVPPLPEWKTSAIHRMGYGNLNKVVLCFDKAFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPVLLALVAGEAAQIMENVSDDVIVGRCLSVLKGIFGASTVPQPKEAVVTRWRADPWSRGSYSYVAAGSSGNDYDLMATPITPTPVVQGAPPQPNNMPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGSPYAPPRQVPPMAHQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPA0</accession>
    <name>A0A914BPA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038077964.1">
        <property type="nucleotide sequence ID" value="XM_038222036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222036.1">
        <property type="protein sequence ID" value="XP_038077964.1"/>
        <property type="gene ID" value="LOC119745578"/>
    </dbReference>
    <dbReference type="GeneID" id="119745578"/>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="378" mass="41375" checksum="7CB5F2069ABA2EB5" modified="2023-02-22" version="1">MAALRRTLQSLCRISREKSSTLRRLPSQNAAIVCRNASAWTFVPDSPPDTLGETTKMNLFQSLTSAMDIALSTDQTAVIFGEDVAFGGVFRCTVGLADKYGKDRVFNTPLCEQGIVGFGIGMASVGATAIAEIQFADYIYPAFDQIVNEAAKFRYRSGNVFDVGGLTIRAPWGAVGHGALYHSQSPEAFFSHVPGIKVVIPRSPIQAKGLLLSCIRDKNPCIFFEPKVLYRAAVEQVPVGDYMIPLEEAEVLVEGSDVTLVAWGTQLHVMHEVARLAQEKLGVSCEVIDLKTIVPWDAETVCKSVKKTGRLLVAHEAPITGGFAGEVAATVQAECFLHLEAPIQRVCGYDTPFPHIFEPFYLPDKWRCLEAVKKMINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BR76</accession>
    <name>A0A914BR76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078798.1">
        <property type="nucleotide sequence ID" value="XM_038222870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BR76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222870.1">
        <property type="protein sequence ID" value="XP_038078798.1"/>
        <property type="gene ID" value="LOC119746083"/>
    </dbReference>
    <dbReference type="GeneID" id="119746083"/>
    <dbReference type="CTD" id="83460"/>
    <dbReference type="OMA" id="MKANFEW"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="118" mass="13365" checksum="A22469E8764766C0" modified="2023-02-22" version="1">MATSRGLHARTDLQVPNEPIVYNELAIRTNMSILSYCRTFVSAISGSSAGILGLTGLEGFIFYFIVSFVFSLMLCVKAGRNWQEFFRHRQPLVTSGLFGGLFTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRV0</accession>
    <name>A0A914BRV0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078690.1">
        <property type="nucleotide sequence ID" value="XM_038222762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222762.1">
        <property type="protein sequence ID" value="XP_038078690.1"/>
        <property type="gene ID" value="LOC119746012"/>
    </dbReference>
    <dbReference type="GeneID" id="119746012"/>
    <dbReference type="CTD" id="6993"/>
    <dbReference type="OMA" id="VNQWTSA"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21462">
        <property type="entry name" value="DLC-like_DYNLT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12669" checksum="B76118DBB2F2F9D9" modified="2023-02-22" version="1">MEEYQTAEETSFVVDEVSNIIKEAVEGTIGGNAYQHNKINQWTSNVVEQCLNQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCYWDNMSDGSCTVRWENKTMYCIVSVFGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWA1</accession>
    <name>A0A913YWA1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044074.1">
        <property type="nucleotide sequence ID" value="XM_038188146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188146.1">
        <property type="protein sequence ID" value="XP_038044074.1"/>
        <property type="gene ID" value="LOC119718744"/>
    </dbReference>
    <dbReference type="GeneID" id="119718744"/>
    <dbReference type="OMA" id="YSACGWV"/>
    <dbReference type="OrthoDB" id="10039923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="39480" checksum="A5C04E9A48782E58" modified="2023-02-22" version="1">MEKATALNGTLWPSLSTQEPFRLYRTYGERQMFAALYIMVSIIGVAGNTFVIAAVVLSRRLRTVTNVFVVSLSTSDLISCFFLPWEAVAVLGENGWPLPQAPWICVTASAVLHVSYGCSINSLALIAVNRWVGITKSGSTSRRIYTRRNIAFMVALSWALPLGIISVPLLTDYGEHGYEPLYSACGWVKANPYTTPLAVTFCICFFPIQLCIIMCCYISIFRYVLKTSRRMLSYDTQTVSGEVSGAARAKRMNMWKRKIAVTKNLAYIVLAYVICQSPYFLAVTQQKYEWGIRLTMYSIAILYCNLLVNPAIYATSHPYFKEAFTFMVRCKDIPEGRVHSQRTFSTSTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXQ4</accession>
    <name>A0A913YXQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRIM56</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044318.1">
        <property type="nucleotide sequence ID" value="XM_038188390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188390.1">
        <property type="protein sequence ID" value="XP_038044318.1"/>
        <property type="gene ID" value="LOC119719079"/>
    </dbReference>
    <dbReference type="GeneID" id="119719079"/>
    <dbReference type="OMA" id="CHTRCTH"/>
    <dbReference type="OrthoDB" id="6049135at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65029" checksum="028656A59517F6A2" modified="2023-02-22" version="1">MATGTALTTSPDQMGKNNLICSICQSRYREPKILDCLHSFCESCLEKYYFNKHEGAARIPCPECQQEMQVPDQGIQGLTTNCYLSGKVETSLQEKVENARSFTGESEVPLCEICDDENEAVNICWNCEQMICSNCKKIHARIATSSSHTVSTLEEIHQGKVALLKSEDHGSCRQHSGKERNFYCETCEEFICQDCTIKDHSKPQHNYFDSVTASVKCRQSLKDLFPAVARHIDGLERSSVITSQDKQEITNNIENTIQDVKDRAAMVRNAILTQENELIDQIRLAENNHYKPLNRHERTVTMMMQRARYSLDTATKFESAATDSQLLTLFPTFRKSIQSLANEKPPQTDHNFHQRCALKFKQSDQINIGKLHPDVLWELWDEFTEFHEGGLLGRIKLKSACGIVATQVDEIAVAEFHPNILPLQQSTSQVIIFNIEGKHKRTIKSTIDNASKHLGIAAARNQLVIADGTSNVKIHNRDNEVVSVSVAVRNDGNIVVGDIKRKVLTEHNANNCSVIRTIPLEIAPSYLAVDVDDSRSLPISRESNPVSAGVVAAHYPEGNFCHTRCTHVINAERVRKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0A6</accession>
    <name>A0A913Z0A6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macrophage migration inhibitory factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045349.1">
        <property type="nucleotide sequence ID" value="XM_038189421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0A6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189421.1">
        <property type="protein sequence ID" value="XP_038045349.1"/>
        <property type="gene ID" value="LOC119719937"/>
    </dbReference>
    <dbReference type="GeneID" id="119719937"/>
    <dbReference type="OrthoDB" id="6080988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14322" checksum="ECF95AA1D06086FA" modified="2023-02-22" version="1">MPLCDIQTNIDNGDISKEFVLQLGHIISHHTSGKASTVRVRAGVRMFMGAGPTSAPLMLIQLHGGFTDGDTNKQICEAIIQCSTKELGIREDRISLVFHYLPPTHVGWSGGRLVADVLPETRLRQLMGGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0H3</accession>
    <name>A0A913Z0H3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044170.1">
        <property type="nucleotide sequence ID" value="XM_038188242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0H3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188242.1">
        <property type="protein sequence ID" value="XP_038044170.1"/>
        <property type="gene ID" value="LOC119718823"/>
    </dbReference>
    <dbReference type="GeneID" id="119718823"/>
    <dbReference type="OMA" id="GFTHNSE"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00043">
        <property type="entry name" value="rRNA maturation RNase YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE YBEY, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="19229" checksum="6BDEBE3DF03F8B37" modified="2023-02-22" version="1">MTLLLRNLQKSVTFDLPKLKADINLLRRIVRAERYDLGVICMQDSQVREMNKMYRGKDEATDVLSFPAHESLAPGRLPDPWSDLADLGDIFLGMSYIQQQCEKDGTNVDDVLPVIVTHGLCHLIGYKHDTDERLKQMHKRELDILTEYNKLTDSNLRPMTNGPAEMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z168</accession>
    <name>A0A913Z168_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">inositol-polyphosphate 5-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.56</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.56" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038045412.1">
        <property type="nucleotide sequence ID" value="XM_038189484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z168"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189484.1">
        <property type="protein sequence ID" value="XP_038045412.1"/>
        <property type="gene ID" value="LOC119719993"/>
    </dbReference>
    <dbReference type="GeneID" id="119719993"/>
    <dbReference type="CTD" id="3632"/>
    <dbReference type="OMA" id="FGMETCT"/>
    <dbReference type="OrthoDB" id="5780965at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039737">
        <property type="entry name" value="INPP5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997:SF2">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12997">
        <property type="entry name" value="TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="424" mass="49176" checksum="4253529906D61935" modified="2023-02-22" version="1">MASESLPSVMLITANVGSIFEDPETMLQGWLHKFYESVQTLKPQLIAVHMQEVGGKDFEQCMGNVDAFVQSLIDSEALKSFDRSLVFLDKDFALVDQFTALGNLYFVHESLQNVQLYDFKTCRFNTIQGKQFVNLINKKTIYEKAKFPQNFFPGTVWSRKGFLRTRWNVENRIFDLANIHLFHDASNMVAMETFPSPYCKYRKRALEHVLQRFSKDKHDNVPLFLFGDFNFRLDSQGVIQTLVAEATPEYTKEDKEVTRITYKDCDGSSKVILILEKKRFEIDDPDRLIGENAKWLLPFDKEMKCFTNQLYEYDRDFPPSYPYSEDVTDGRSYMKTRVPAWCDRILLSKAAKALVKEDLYNKAMYSVIGQEVCMGDHKPIFLSFRLAPTQGMPVNHKRSPALTPYYKVSGALVYYPLIYRETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z200</accession>
    <name>A0A913Z200_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044715.1">
        <property type="nucleotide sequence ID" value="XM_038188787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z200"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188787.1">
        <property type="protein sequence ID" value="XP_038044715.1"/>
        <property type="gene ID" value="LOC119719358"/>
    </dbReference>
    <dbReference type="GeneID" id="119719358"/>
    <dbReference type="OMA" id="MTTYRVI"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="41092" checksum="6A454A39D3B7E4AD" modified="2023-02-22" version="1">MDDEMANGSIGNSTESPRFEFNDYTQRVIVAVMYLIVILLGTVGNIMVILAVMLSKKLRTATNAFVVNLAVADLSTCLVLPWTVVATLSTNGLPVGEWVCSVTAVVQATAIGCSMYTLASIGLQRLLLIKRPMTTYRVIYTPRKLAVWLAVAWCIPLLVTLIPPLADVGAVGYNKKYRHCGFPSTHPRSNDYDLIIAAGLYPIPLITIIVCYVLIWKHLRNHAKKVTAPESSAESMATQMTVASESEATVNSNHAKTLTATKGTLRKSDVSRRQTEITKNMFYIVCAFLLCLTPFAICLFYDDSDPFLPYASAILVFNSCVNPLIYATKHRVFKAVFRCILHRKWEDIPEPSDFLKTLISGKMPCCGGGGMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2F5</accession>
    <name>A0A913Z2F5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044870.1">
        <property type="nucleotide sequence ID" value="XM_038188942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2F5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188942.1">
        <property type="protein sequence ID" value="XP_038044870.1"/>
        <property type="gene ID" value="LOC119719469"/>
    </dbReference>
    <dbReference type="GeneID" id="119719469"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="210" mass="22692" checksum="5BE4BCBC08489717" modified="2023-02-22" version="1">MSVDLGPDRTSSRESGAELPPDDLSETKLQPKPVTWASKIPDEFGNPDNCHLEAEPSMMAEESNLPLSTDKSATQSECPSPILDSLPEADELTPQFGSEVDIGAEVEVGTCGSPDASSLPEAEVPVPGMYIPAGDLSRETATTGHSSESEVNGSRPSRERRPPRRFTYEVLGQPVTHQLQAGVWSHWIPEFIIPTFLTARKSCIGTLQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2L5</accession>
    <name>A0A913Z2L5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046074.1">
        <property type="nucleotide sequence ID" value="XM_038190146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2L5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190146.1">
        <property type="protein sequence ID" value="XP_038046074.1"/>
        <property type="gene ID" value="LOC119720474"/>
    </dbReference>
    <dbReference type="GeneID" id="119720474"/>
    <dbReference type="OMA" id="GYCHERI"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="216"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="535" mass="61397" checksum="B25C4F95D5D231DC" modified="2023-02-22" version="1">MVIAEEPVRELSVGDPEVKSVTSLQSAVTPEVFDWEDRLSRFSDWSKVLGAVARIRRLNRKEKDNSLSTLQEQKEAEKHIVRSVQRQAFPQEIQSLRYSSRVKAISKICSLNPFLDNEGILRVGGRLRNAEVPDSIKHPAIQPKDGHLTRLLISYVHNKVQHQGRGMTFNEVRAGGYWIIGGIKVVATHIHRCTTCRRLRRPVEEQKMADLPKDRVEPSPPFTFCGMDCFGPFTVREGRKEIKKYGVIFTCMSSRAVHIEMVDDMTTDSFINALRCFIALRGPVQLLRSDQGSNFVGAKNEFREALKELDMERVQVFLAKQQCQFVMNAPHSSHVGGVWERQIKTVRSVLSSIIQQSSGRVDAATLRTFLYEVMAIVNSRPLTTVNLHDPLSPEPLTPNHLLTMKCTAALPPPGKFVKEDLYIRKRWRRVQYLAEQFWGRWRKEYLSSFTSRQKWHTPRRNIKVGDVVLLKDEEAPRMEWPLAIVIETIENDDGLVRRARIRVGTKHLDKEGRRTGKPSILERPIQKLNLLLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2T4</accession>
    <name>A0A913Z2T4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045306.1">
        <property type="nucleotide sequence ID" value="XM_038189378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2T4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189378.1">
        <property type="protein sequence ID" value="XP_038045306.1"/>
        <property type="gene ID" value="LOC119719907"/>
    </dbReference>
    <dbReference type="GeneID" id="119719907"/>
    <dbReference type="OMA" id="CYWEEIE"/>
    <dbReference type="OrthoDB" id="5966706at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036788147" description="Insulin-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12893" checksum="44877DB41D38DA13" modified="2023-02-22" version="1">MTRWIVALLLCACVAVALADKAPSAATCEALAATVKAEGKKRWDGPAHTFCGETLTEKANAYCHCQVVPRKRELELSEFLTPVKANSFLSGRNIAKRSLTEECCHEGCYWEEIEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z379</accession>
    <name>A0A913Z379_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045160.1">
        <property type="nucleotide sequence ID" value="XM_038189232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z379"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189232.1">
        <property type="protein sequence ID" value="XP_038045160.1"/>
        <property type="gene ID" value="LOC119719735"/>
    </dbReference>
    <dbReference type="GeneID" id="119719735"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="24167" checksum="B3DD8F76F8351F9F" modified="2023-02-22" version="1">MGTLLKQPKVSNAVLHSCCIQGLCVLDVHEISLVEDINHAAHEEAKISSSTQRIGLLGTLLKQPTVSNAVLHSCCIQGLCVLDVHEISLVEDINHAAHEEAKISSSTQRIRLLGTLLKQPTGLCVLDVHEISLVEDINHAAHEEAKISSSTQRIGLLGTLLKQPKVSNAVLHSCCIQGLCVLDIHEISLVEDINHAAHEEAKISSSTQRIGLLGTLLKQTMVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z478</accession>
    <name>A0A913Z478_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046516.1">
        <property type="nucleotide sequence ID" value="XM_038190588.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046594.1">
        <property type="nucleotide sequence ID" value="XM_038190666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z478"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190588.1">
        <property type="protein sequence ID" value="XP_038046516.1"/>
        <property type="gene ID" value="LOC119720757"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190666.1">
        <property type="protein sequence ID" value="XP_038046594.1"/>
        <property type="gene ID" value="LOC119720814"/>
    </dbReference>
    <dbReference type="GeneID" id="119720757"/>
    <dbReference type="GeneID" id="119720814"/>
    <dbReference type="OMA" id="YHNNGSN"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="498" mass="53838" checksum="B8146FD257A0C825" modified="2023-02-22" version="1">MAAYIRVVEDELDPEVIELPVEPDGTMLLSTLTAQFPCASGLKYRNPGTRSLRGLRVVEGRIQPPDDVWGDHLYIAVFPKDNKRKGDDSSENNSAKTRRVENKTVDLIVLGLAWKTTVASMREYFEKNFGEVLMCEIKKNLENQSKGFGFVRFKDYKVQSSVVSQRHNIDGRYCDVKIPDSKNSQDSKKMFVGRMPQDMTKEDLYNYFSKYGEVTDVYIPKPYRCFGFVTFLRSDVATVVASEDHIYKGTSLQVNRAEPKNPKIRMQGDDHYPSYGYGGGGGYSDQGRYYSRGDYPQSGRGRGRGGGKIVPRGGDGYRDRDQGSIGGPGNQVNTSNVGGGMGGGMGGGMGGGMGGGMGGGMGGNPGGQGPGQMGNFPWNQAMLAALSQAGWGMMSNMLAQGMQQGMQQQQQQQQQQQQQGNQPPQQQPQQQSQPSQGSLSQGSQSSQVSNQVMQTPNSSGGYGSGQQSLGWGSSQSSVGETGSPGYLMGESKSGGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4B4</accession>
    <name>A0A913Z4B4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046562.1">
        <property type="nucleotide sequence ID" value="XM_038190634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190634.1">
        <property type="protein sequence ID" value="XP_038046562.1"/>
        <property type="gene ID" value="LOC119720788"/>
    </dbReference>
    <dbReference type="GeneID" id="119720788"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037987427" evidence="1">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="23909" checksum="F3D8F66CF557545C" modified="2023-02-22" version="1">MAASLSSQIAYAFFGIVIVLCIATVRCAPVSNTSSSTTNLVPCESTDAATTSHIILPHATAFLDACKNVFDDFVVSRSGPLPNDYLELFAEYIPNIAVFSDNMSENERLATHYFILEGFRRPMEAVIIDDGQYPETQRFDAELQNLSQLLQTVTQGVQELVCSNGASGQSPIGAMEDLLLPSRDNYVDRILWDYTVLYYMNQYSSNLHSDILISIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z607</accession>
    <name>A0A913Z607_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046446.1">
        <property type="nucleotide sequence ID" value="XM_038190518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z607"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190518.1">
        <property type="protein sequence ID" value="XP_038046446.1"/>
        <property type="gene ID" value="LOC119720712"/>
    </dbReference>
    <dbReference type="GeneID" id="119720712"/>
    <dbReference type="CTD" id="100885850"/>
    <dbReference type="OMA" id="KYDTTSW"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000003">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000007">
        <property type="entry name" value="alanyl-tRNA editing protein Aarsd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="9">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="410" mass="45438" checksum="082E7DE188B9F248" modified="2023-02-22" version="1">MAFACQKNSYLQELTTRVVSCTPAELKQVVNGKKQTLQGYEVITEDTVLFPEGGGQPDDRGTMNGIDVLRITRRGADAVLFVEKAIEAGTEVVQKVDWTRRFDHMQQHSAQHLITAVAEAKYGWPTTSWDLGKEKSFIEMDTPKIQAEHMQELEREVNEAIRKQLAMTPRLVDLGSAVLNCVRTRGLPEDHVGQVRIVEIETIEANTCCGTHVANLSHLQSIKLLGAEKGKKNKTNLYFLAGDRLLNYLGKCLANEKLLTGFLKCGPEGHPQAAEKIQKSLKVANKSTTTLLRDLAALEAYRYNNQANKDPVFVLHRKEGDLEFLNMVANEINLQNCLALLTAGDEKGVGLFLVAGPDDIIKEVGPQIAECLEGRGACKNGRYQGKANKLSKRSTAEETLHQYIPRLPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z717</accession>
    <name>A0A913Z717_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047494.1">
        <property type="nucleotide sequence ID" value="XM_038191566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z717"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191566.1">
        <property type="protein sequence ID" value="XP_038047494.1"/>
        <property type="gene ID" value="LOC119721487"/>
    </dbReference>
    <dbReference type="GeneID" id="119721487"/>
    <dbReference type="OMA" id="CRISSEH"/>
    <dbReference type="OrthoDB" id="6062494at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="29467" checksum="8AA691E88D4185B8" modified="2023-02-22" version="1">MRGVSHMFGLSKSTVHSCIHKVAATISSRRHSVIRWPDQTRQAHIAEGFAGESCLRGIVGVIDGTHIRIINILNGQPDYINRKSYPSVQLQLVVDDMMLITDAYVGWPGSVHDARVFRNSPLYHDVEDGHKLAEHQYLIGDTAYPLRSWLVTPFKDNGHLSQQQRRFNRMLSGKRQVVERAIGHLKGRFRRLRELMFHDISQICQFIMATCVMHNLCVLSDDDVSSFINFDDQDDMELENIFADATGGHVRRNALVAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA02</accession>
    <name>A0A913ZA02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038048459.1">
        <property type="nucleotide sequence ID" value="XM_038192531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192531.1">
        <property type="protein sequence ID" value="XP_038048459.1"/>
        <property type="gene ID" value="LOC119722423"/>
    </dbReference>
    <dbReference type="GeneID" id="119722423"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="56985" checksum="4BB23CE4076D3744" modified="2023-02-22" version="1">MSKTQGREVTDDVVMASQRAKEAFYTNLTGTTPFEISLAVAIGPASELLRWTLIPILVMLFGGVVKNKWLGFVLDFITLVIPLLLAFTVWSDFLQRFLVVLLVTSATLLLAAYLLQPMKAQRVKRPSKAKTVAASRPLWELPMESEQPLFMTMFRVHGMVASAIAILAVDFPVFPRRFGKTETYGTGMMDVAVGAFMFMNAIVSKEARGKHQNIFSCGISGAVKSLTKTVVSALPLFLLGTVRLISVKTSGYHEHVSEYGVHWNFFFTLAVVIVGSSACLLFIPTSLSVPLSLALAVGYQHLLTNHGLGQFVLTGSDGRGSREGLLDANREGLVSCLGYVAIYFAGVCAGKFLLIRRTLFFDWWLAFLLLNVVNVLLWILLEATSVYIEPVCRRTANLPYIIWTLSFCIQLLVSYMLVDIVLALGKEFIWKSPYKLSANKVAKHPLLPDSILVSALRPNLLLIFLLCNLLTGVVNMSMDTVSQPTPVSMSVLVLYMLGLCLIAIGLHVKGMKLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA21</accession>
    <name>A0A913ZA21_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048612.1">
        <property type="nucleotide sequence ID" value="XM_038192684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA21"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192684.1">
        <property type="protein sequence ID" value="XP_038048612.1"/>
        <property type="gene ID" value="LOC119722517"/>
    </dbReference>
    <dbReference type="GeneID" id="119722517"/>
    <dbReference type="OMA" id="RERPMIH"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF88">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="505" mass="55360" checksum="5627AAB33BBA4544" modified="2023-02-22" version="1">MKMDEDDKSFEYLEHKNPVSSPSPPIIGSTSGRTHPIIHPIRDAPLCTQCKDLRLTFFDPHCPGCWSLAQDPRTTVGELFAVLRQWVPQVQRSVLAIGQEILQRDFHIDDRDGLTDMTLLHYASKAGCEGVGERSDAVELVSLLLERGASPELRSRWTDMTVLHYAVFFDVVPLIRLLLKATQFKDLESSCREFENGTPLHIAACNGCLESARCLLQLGANCRARDAQGRMPLHCVPDASDVARSGWEVTAGKLRQLLHPDSQFTRPRYSPQNYDDVPSRVLLTSLGLGLGDRVYVGDSKAGTLRFYGTTQFAPGVWAGIELDEAIGKHDGTVEDVAYFKCPPNHGIFAPLSKVSKFVTSPRPSTPRSVGGGAIAVSHGKIDVSHVSPKVDTGLRSRTLSVASIKQEDISVGDRVTIAGQVPRHGIVRYSGLTQFAQGWWYGIELDRPEGKNDGSVGSVRYFTCSPQHGLFAHSSKLTRCNDYSQNSLDSSTSSQAAQTNAADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAX3</accession>
    <name>A0A913ZAX3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048928.1">
        <property type="nucleotide sequence ID" value="XM_038193000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048929.1">
        <property type="nucleotide sequence ID" value="XM_038193001.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048930.1">
        <property type="nucleotide sequence ID" value="XM_038193002.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048931.1">
        <property type="nucleotide sequence ID" value="XM_038193003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAX3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193000.1">
        <property type="protein sequence ID" value="XP_038048928.1"/>
        <property type="gene ID" value="LOC119722728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193001.1">
        <property type="protein sequence ID" value="XP_038048929.1"/>
        <property type="gene ID" value="LOC119722728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193002.1">
        <property type="protein sequence ID" value="XP_038048930.1"/>
        <property type="gene ID" value="LOC119722728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193003.1">
        <property type="protein sequence ID" value="XP_038048931.1"/>
        <property type="gene ID" value="LOC119722728"/>
    </dbReference>
    <dbReference type="GeneID" id="119722728"/>
    <dbReference type="OrthoDB" id="5946895at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51532" checksum="E6E0A99B7A16BE7C" modified="2023-02-22" version="1">MLNQSRAKRPALRQAASPRSELSKASAKAATPVTDDRQLPCVWGQPFPVNGQGVMIFNTDRHMMPFYACVEDEDPSSNVLALHVGVGYASFVMNSAGDANPTELRRVTEADTPRCGVEEGKVSYWYSYDRDNLVLKYGKGYRMEESTLMTHDFLEGVTDEEDQMKIREDLQPFFTAEVQKFVRQYDEKASIQMYAARGTEVTEPMVEFDKQPLICNLPPTVMDSSKANLFELDRGDHIFSASLPAACKELYSNVANCELNYTEVEGEKVLLSDAIRYSLAYGILKDKIESKVGELGDNPNETYLRVTLGSSLGKSPGIPYVLEIWPGGHYSPIHNHGNANAVIKVLFGSITIDIYNKQSETSSHDPLFTFEACAGDATWLNRNWYQTHKLRNPGKEYCATIQCYNYDAGDTTYWPYFDYVSENQTIDEFYPGSDFGFLEMRSQVMKEYTDFVYGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBN2</accession>
    <name>A0A913ZBN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038049193.1">
        <property type="nucleotide sequence ID" value="XM_038193265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193265.1">
        <property type="protein sequence ID" value="XP_038049193.1"/>
        <property type="gene ID" value="LOC119722870"/>
    </dbReference>
    <dbReference type="GeneID" id="119722870"/>
    <dbReference type="CTD" id="4249"/>
    <dbReference type="OMA" id="HCESKLK"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="19">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="18">
        <location>
            <begin position="209"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="789" mass="90219" checksum="B7C65369301BB3AF" modified="2023-02-22" version="1">MFGRKSCRVITSSRIGIFLLFLMLTWVYAFMNYAMYRAQPGVRESDRLRQRILEDSELYVKALANEEKDGLNAQSSGVVYDLKRTLAVLLENILQRLGNVEQKVEIIYTNGSQIFRNLTGLAAAEQRHLAKNESEDPQDSIYTNKKNKGKRKGLSDYDEVDEDDRPLLAKDLIMQPEMKCSYSRDELRGYPDCDRKVAWMREMWSSDPCYGRYGVDGSECSFLIYLSEVESWCPMLQWRPQSPKQLLTKSTRPKAMVRTDKQGLMNILNKANAVKLEWVKLRIDRMWEDKWIPAIEALQTKQNLTNSEQKKILVHMGLLTKESGFKIAENAFSGGPLGELVQWSDIIASLYILGHDLEVSVMYSSLKSFLKGKGVVSQSCPIGGERPFDLVYIDIVGLKQFKKAAGPLWKQLNCMLRVIDSFGTEPAYNIRSYSKRTGRKTDWGGWELLPKQFFTMFPHTPDNSFMGFVVESNRLAMDATVKRDNKALVYGKMSYMWKNANAMKFLDIINQYFEIHATVHIDQNQTEEVVAVPSYVHNHGILMGPDLQQLLQQTKLFIGLGFPYEGPAPLEAIANGCIFLNPSFDPPKSKVNTKFFKNKPTDRELTSQHPYAEVYIGKPHVQTIDIQNFSALQATVEAISQSDAPAPYLPYEFQCEGMLQRLSVYIENQDFCSRPKSWPPKSAMHIRTSDINESCSKRCMKDDLICEPAWFHLLNYKDVLEKRFGMSCSSSEQIEEVYVPAINPVRSSCKTQSKPLLYSCASQDTELRRICPCRTYIKGQVALCRECIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBR9</accession>
    <name>A0A913ZBR9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone deacetylase</fullName>
            <ecNumber evidence="14">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038048330.1">
        <property type="nucleotide sequence ID" value="XM_038192402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192402.1">
        <property type="protein sequence ID" value="XP_038048330.1"/>
        <property type="gene ID" value="LOC119722342"/>
    </dbReference>
    <dbReference type="GeneID" id="119722342"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10005">
        <property type="entry name" value="HDAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000004">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="49233" checksum="D974E27A7299799A" modified="2023-02-22" version="1">MSSPTIAYFYDADVGNFHYGPGHPMKPHRLSLTHNLVLNYGLYKKLQVYRPYKANMHDMCRFHSEDYIDFLQRVTPQNLQTFTKHLSHFNVGDDCPVFPGLFDFCSMYTGASLEGTTKLNNNLCDIAINWAGGLHHAKKFEASGFCYVNDIVIAILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNHFFPGTGDMYEIGMESGRYYSINVPLKDGIDDQMYFGLFKPVIQSVMEFYRPSCIVLQCGADSLGCDRLGCFNLSIKGHGECVKFVKTFNVPTLVLGGGGYTVRNVARCWTFETALLLDEDISNELPYNDYFEYFGPDFTLHPDTTTRIENLNTKQYIDQVRQTVQENLKCIAHAPSVQMQDVPPDLLSLEETEEQDPDVRNSTKDQDTRIEAANEFYDGDKDQDKEDVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCV0</accession>
    <name>A0A913ZCV0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048871.1">
        <property type="nucleotide sequence ID" value="XM_038192943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192943.1">
        <property type="protein sequence ID" value="XP_038048871.1"/>
        <property type="gene ID" value="LOC119722691"/>
    </dbReference>
    <dbReference type="GeneID" id="119722691"/>
    <dbReference type="CTD" id="55266"/>
    <dbReference type="OMA" id="MSSFACC"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="35212" checksum="DF69041E125F9939" modified="2023-02-22" version="1">MMLFGALLSVIVPLSLLTWAISMLGFTYMGSEAPIYPISPGRWLLTVTLPLFLAISGLRKKSVTSGGAILGYLVGFTMLLASYSFFMALLAFFYTASKATRFKAEMKKKIEADYKEGGQRDWLQVISNGGIPTSLAIIYVVDSGFRDLPLDFRSRYDTTWTALALMSAYACCCGDTWASEIGTVMGSKTPRLITTLSKVPVGTNGAVSFVGLLSSAVGGFMVGCGFYIGLLISFSSPAFKTATPQWPVMVFAALAGLVGSLIDSLLGALFQYSALDLRTKRVVSTATTTTEYICGWPVLDNNGVNMLSSLLTSMIMPGICFAWWPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD31</accession>
    <name>A0A913ZD31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049692.1">
        <property type="nucleotide sequence ID" value="XM_038193764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193764.1">
        <property type="protein sequence ID" value="XP_038049692.1"/>
        <property type="gene ID" value="LOC119723203"/>
    </dbReference>
    <dbReference type="GeneID" id="119723203"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517958" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="44"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="356" mass="39107" checksum="A4920CFBA76E4839" modified="2023-02-22" version="1">MVAMTASGGKWMISSKQLKLSVPMLHFILTLVALAWFLLAVHATTPANNGPCPDGWEVQGQKCFRFLKESKNWQDSRDYCIGIGGDLVVLESQAETDYLVEKMRAYDAHTFLGCRDVETDGHWVCEGYDPSTTYFDEGGSSSGHWTTENPFQTNGGTDENCMEIYHEHSWSVMNDVSCDTLDPLVSCQLKLEDTTTPITTLPQQPTTIVITTPQQLTTAPQQVTTAPQQMTTAPEQVTTAPGQVTTAPEQVTTAPEQVTTHQTAYSSVKTPNWLFSSPFGPGHCLGDRVVTQFTTRLTLQCALRCLRAQWCASFNTIKDGDQTKSMTCQLNDAGAGEMSSLQGTVGCITFNKLFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE51</accession>
    <name>A0A913ZE51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050063.1">
        <property type="nucleotide sequence ID" value="XM_038194135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194135.1">
        <property type="protein sequence ID" value="XP_038050063.1"/>
        <property type="gene ID" value="LOC119723468"/>
    </dbReference>
    <dbReference type="GeneID" id="119723468"/>
    <dbReference type="OMA" id="PRCVNYA"/>
    <dbReference type="OrthoDB" id="10004661at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF9">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 middle" evidence="2">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="3">
        <location>
            <begin position="504"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="72501" checksum="3CA71C948A45EB1F" modified="2023-02-22" version="1">MTLTWSFRCACWGIVSSLLVAVLFGHCLFCQAHLALRITEGAVAILLFLSSLITFHISTLRCSESHTLSSLLLSYWWHQGEWLATPFILAKANRMWKHPREAQEDLIRELTRRHAKTEYGRKNRLGEIRSLGDLHKKHPLTTYDHFKDYIQRLADGEEGVFLGERPLRFGVTSGTTGTGKKVPYSGFFWEGESFALKLYRLGIYQGISRPSSVQKRCFLYTHPKFSVTKTGLAAASFLFVTEKDTSIVIIPEQSSPLPAFTITHEPSAMYVHMLFAIADPNLAMLQALFTPQLYRALTCLETNWRAMLEDLSTGKINTKIPLDPDVRRSLQGYLRPDQARVCQLRREFEKGFEGIVKRIWPHLRALDGVSISGFNEKLQEKYANGTVCVGAFNYGTTECGCPTVNMWVTEEEPRYVIIPNIVVFEFIPEEECLEKDPTTLLIDEVEVGGRYELVSTTRTGLYRYRSGDVVQVTGFHERCPVIRMLYRIGEYLNLVYEKMNAPVVDAAIKATVGSWPRVQLVDWTCAESPIYDDSPELYYIVFIEIDEEQTDFTENQLSKFDEYLQHHQYYYKNLRASRTISAPHVHLVAQGAFTDLEDFTISRTTASSNQYKTPRKLKTRELVEWMMERVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEA1</accession>
    <name>A0A913ZEA1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2</fullName>
            <ecNumber evidence="14">2.4.1.313</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-1,3-N-acetylgalactosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-Man]-L-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37667"/>
            <dbReference type="Rhea" id="RHEA-COMP:13308"/>
            <dbReference type="Rhea" id="RHEA-COMP:13618"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:136709"/>
            <dbReference type="ChEBI" id="CHEBI:137540"/>
            <dbReference type="EC" id="2.4.1.313"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.313" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038049275.1">
        <property type="nucleotide sequence ID" value="XM_038193347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193347.1">
        <property type="protein sequence ID" value="XP_038049275.1"/>
        <property type="gene ID" value="LOC119722935"/>
    </dbReference>
    <dbReference type="GeneID" id="119722935"/>
    <dbReference type="CTD" id="148789"/>
    <dbReference type="OMA" id="GKWAEHD"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF219">
        <property type="entry name" value="UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="512" mass="59146" checksum="11034360665C5A4C" modified="2023-02-22" version="1">MADLRIFSISLLCFLSASIIAWVYHNHDLYVLFRMPETEDKMSHEIVIGVLSARENTAQRQAIRDTWGQYIRDHSKLRGKMLARFIIGNRGCEIPHEFREDQYSCQSMLLKTKNVNLEKEMVAFDFQMPLSKNYGRRTSSGEYYGIDFKVNYAVIVKKLGVYAAGSLEQQCSVTLYDTWSQEPVISATFPPGDPSELQDGYRYRNVETYLFPKDFEGTIVVGPLSEDIQLSTISQNGRQIHNTHRILSIRSFLRTCKTATFPNEIGLFNLPFLPGNFIFEIYKPEEVEGMLNSSAALVQSQIEVNRQESQALKDEQQHHNDLLLVDAVDIYRNIPHKLLHFFHWVTSTTEANFIIKTDDDCFMNVNAIMEMIQDGQVAANSRTWWGNFRTNWPLDVLGKWAEHDYPSPVYPAFACGSGNLLTRDLVQWIAQNSQFLHTYQGEDVSMGIWLASILPTYLNDRRWQCDDECQEDALVLPEQSPQQLRVSWQNWIRCQNPCSCDWLNKHPRSCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHA3</accession>
    <name>A0A913ZHA3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051167.1">
        <property type="nucleotide sequence ID" value="XM_038195239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195239.1">
        <property type="protein sequence ID" value="XP_038051167.1"/>
        <property type="gene ID" value="LOC119724265"/>
    </dbReference>
    <dbReference type="GeneID" id="119724265"/>
    <dbReference type="OMA" id="DNHTFAC"/>
    <dbReference type="OrthoDB" id="6138508at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF62">
        <property type="entry name" value="CVP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037884294" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="304"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="49579" checksum="9E2033B8C4FA4736" modified="2023-02-22" version="1">MTSTCRQVLFTCLLLAVIVHTDAARRRRPVIPGKTQPQATQAPVEQTQNSPNQAKGINSNALADMERRMANVEESTLVIKSEMREAKSENTRLKEEIQRMGATMEQLDEANQRVEELERMLSKFENFFGVLYTELPDVFAEEMSLPQRFSRLNSYLGNKESELMMLRPNPPFVTADPADNPVDEELLGLAVDELNMENTKLRRRLDDMETRMVAVPPSGVETNDPNRVVPAPLDDEIQERLTRLERLMALKLAPLIDEEDDTDNVDLGDLGGNKRLTSGGATVTLSDSDAEILRTELDSVRSIASTRKSVFSAAATRHMHGEAGVQKPVSYDHIFSNKGDHFQEQNSTFICGITGYYFITFTTRSYDNRYLGVSLLLNGERVVSVSAESDPVKNQMMSQSLILHLTPGDQLWVSVAPSTVYSIHSDRFGKFSTFSGFLLFKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHC4</accession>
    <name>A0A913ZHC4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051187.1">
        <property type="nucleotide sequence ID" value="XM_038195259.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051188.1">
        <property type="nucleotide sequence ID" value="XM_038195260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195259.1">
        <property type="protein sequence ID" value="XP_038051187.1"/>
        <property type="gene ID" value="LOC119724280"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195260.1">
        <property type="protein sequence ID" value="XP_038051188.1"/>
        <property type="gene ID" value="LOC119724280"/>
    </dbReference>
    <dbReference type="GeneID" id="119724280"/>
    <dbReference type="OMA" id="LERMINY"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="59"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="497" mass="54427" checksum="242D1E729A4874AF" modified="2023-02-22" version="1">MEMETSRETSPILSPSNASLNGTGPHSLSLNHTEPAKNGDEKYEELDEPNDSQSGNGLNVWQAVLFITGLLVDYSLLAVEALVVNTGWIGLFLATVLCSVIVFTAILIGRCWNIVRGRWQNERHPYGAIGYEAFGSWARTAINVIVDICCFAVTTGVLMVTAENLFVLGGQALHGKYCLLPVVIAVVACPFMWLGTPRDLWQLGVWGALTGTLVYLLLFIGAIVDDEDTEADTDYSNVTNVTVGTPSNVGHVRGTLLHSTVLVHLAEICGIVQVALGIHYIAPGLQRDMKRPEKFTKTVCVSFAYTFALAIPVLVVTYVFQRDRLAYVTADTTVLAVLTPGPLSVVAAALFLLRSVMVLVSSNNPLFQSLEERLDIPSEFTWKRVVLRTVVFVMQLLVGETIPHFGVIFTLLGGICFPILVLMAPAMCYLRLRNIHTPEKYKESKAIWILETVVCWLIIVITPIMAVIILYVMGAGIFQGKTVLTVPCFINATLAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHH1</accession>
    <name>A0A913ZHH1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050844.1">
        <property type="nucleotide sequence ID" value="XM_038194916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194916.1">
        <property type="protein sequence ID" value="XP_038050844.1"/>
        <property type="gene ID" value="LOC119723994"/>
    </dbReference>
    <dbReference type="GeneID" id="119723994"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="54247" checksum="85980C364F69D17C" modified="2023-02-22" version="1">MASPSPGTSQHLVNKCAKCKTSENPLVPSLIPDQDELCSLCLLQTQIQNLHLRNELETIQQEGDIVSGMLEGEAPDRETQELVKVRQKAHGAIELMMGLHVPKQTSSGKEEVGKFEPTFGDVQVMEALAPDVCLRLRKGSLRQFHSILHPVNNMVDGKMEFKGTLFEVFDSKQTNMNEYNDQNKRARKLVEEMTRCNSKKIFLLDGHGRMLLSIIHAMIEQGLDPDSYEFVVVDNVKECHCFHEHLFPQSVTCECKDILEIGLGKTDMLYMNFCSIPSRVENILFNKEEVLKWVWERMKTMKCGIMISAVIRDTRTEVDQRDRIFTAIGPSKGIHINDYHLRAAGFEAFLIDETLFGGEEVSARKHFKTWLIRPENCVVRNDPNILRTTFGKNEINWDYRLELVPGVCVRWDQNPDQKYRITERTALRVRLVEHPGNGPSKGRQRDIRHVNVWTDPYELKLKPVLTRFPFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHH9</accession>
    <name>A0A913ZHH9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051242.1">
        <property type="nucleotide sequence ID" value="XM_038195314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHH9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195314.1">
        <property type="protein sequence ID" value="XP_038051242.1"/>
        <property type="gene ID" value="LOC119724319"/>
    </dbReference>
    <dbReference type="GeneID" id="119724319"/>
    <dbReference type="OMA" id="PRDCSHI"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="181" mass="20302" checksum="98F20C28AFB254DF" modified="2023-02-22" version="1">MASTRYTVRKGQPEDCKHIVRLLKEHATSAISNTEEDLQNDSFGDEPLYHFFVVEAMNDGTDAKENAAAEIVGFSAYFFSYSAWTGRMIDMDELYVQDSHRGKGLGKALMAKVAKVGVENKCIGMDWILGGSNKSAWPFYNHLKSIDMSAHFGWRFMTVSGENFAQLVNSEIKPGLNIQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIC7</accession>
    <name>A0A913ZIC7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051542.1">
        <property type="nucleotide sequence ID" value="XM_038195614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195614.1">
        <property type="protein sequence ID" value="XP_038051542.1"/>
        <property type="gene ID" value="LOC119724523"/>
    </dbReference>
    <dbReference type="GeneID" id="119724523"/>
    <dbReference type="OMA" id="ARECHQS"/>
    <dbReference type="OrthoDB" id="10068084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="418" mass="46159" checksum="A22F422DB129AEEC" modified="2023-02-22" version="1">MEALLALQQSVVSQIGCLQEEQLQQVCTELGVDEHTASKESARLALIRRLTRHLNSETMEDMEDKGQKVFEDLRDFLKTITPGTSSASKDPPATPESSSTSTVEPAPSPPALPVNQMVGLLKKEFRISGQVGEPGQKDRLSHSNLIMQIESGLRKSYKEVEIVEAVIRSISPGMRLRSYLESTEGLTLPTLREILEAHYREGNATEIYQELSSASQGSTESAHDFLVRTLDLRQKILKASKMESTIKYDPGLVQNMFLHSLNTGLQNDNIRGELKPLLFDPTTSDESLFRQLKIAEGREIVRLAKQKKAKTAVKVQEVSAVEKQQLDLMKQLQQIQADLAALKVSNKQAAEKPKSSEGGSRNPPSREWGCNSCRQAGKGPECDHCFACGSSEHFRRGCKQRRQTKQSGNGSRASGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKS3</accession>
    <name>A0A913ZKS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transmembrane and coiled-coil domains protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051690.1">
        <property type="nucleotide sequence ID" value="XM_038195762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195762.1">
        <property type="protein sequence ID" value="XP_038051690.1"/>
        <property type="gene ID" value="LOC119724632"/>
    </dbReference>
    <dbReference type="GeneID" id="119724632"/>
    <dbReference type="OMA" id="LITLWKH"/>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF14">
        <property type="entry name" value="DEMENTIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76052" checksum="7F2C9D7AAD46826E" modified="2023-02-22" version="1">MAHKMVVGKRLSDNLDKRTAKGMKRVHEDRHRNTSGSRNTLDVDPNYRRARSAEDLSPNSIPNEQPLPSTPPVTKHSFGLKGLFHRKKENDAAPPIIEISAHNQEPDVHPVSYAQNIYNPPVRPNAFNRVLQQIRSQPAMLRRASETKVPSNSKLTSMRTRSDGSDNDKEDTGRKKGSSLPRDVEMRARAESARPATKEDQVDFVHLAHTQTDTTLCHTPSYGSDMEQQDETDSVTSPDPHRTKFLIEQTLAKIDRTKEAMKAEQIAKDENVTEYLKLSAQADKIQMQRIKTVFEKKNQKSNATIAHLQKKLENYHKKLIELETNGAVGPRRPKEVFHGMQQGLRGVRDNIKEGITGFSGGMADRIGGGISGLTGLTQSAASVVVSKPKEIAHKFKNKFGSADNIDNTDEEEDVDQPHKTGRSSWFAPTPATMPKSNSEGEESSSMEMTENGHLMMRDELEEHPLVGRMTILQDRISELAASEALLHVKIEELKEQNREQYQFFNQALADERYRAERLEEQLADLTDLHNHALTNMQQELSSMEERLEYRSAERERDVLDNVDQCQTRISKIELAQQHQQVITLEGYENANARALLSKLINVVLSVLAVVLLIISTITNAVSPFVATRGRLLTTVTFSFLFCCIWQRREVIEDLTQHIVENYKHLFYVNSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLI2</accession>
    <name>A0A913ZLI2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052658.1">
        <property type="nucleotide sequence ID" value="XM_038196730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLI2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196730.1">
        <property type="protein sequence ID" value="XP_038052658.1"/>
        <property type="gene ID" value="LOC119725332"/>
    </dbReference>
    <dbReference type="GeneID" id="119725332"/>
    <dbReference type="CTD" id="55761"/>
    <dbReference type="OMA" id="PDDHAKQ"/>
    <dbReference type="OrthoDB" id="2115703at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052630">
        <property type="entry name" value="TTC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091">
        <property type="entry name" value="TTC17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130296" checksum="0E3DE5F432FD3A5B" modified="2023-02-22" version="1">MESRATVRCGSQRGAQKMKILRRTVLLGVCLLSLTGCEATTHWLVTEEGLITQQLNSHFNMREPYNFISFLKQGRRGESVRELELELERQKSEIEANEDKDLDLEQRFLKTDSDCVAAQEPLAQQNLYPTVVVPLFLKSIKAKDFLDTSGPLEVSRNAMPNCTKLFYLPFSMHAYDHLQGIQERHSLTDFVEENVGDQLKGVGPEGQTGRLLYRALKRNKTSWELYTLATFYWRAMGNSLQVIECGRRALHFASHKDKNIALVNMASVLHRSHQSASAAVMAHAALEAGQEVPKLHVLLGSIYATIGEYDLSVYHFEQAIELGLPETCWPQQRIHAVRCHQKLEQALEAQHMSLQRTLSELQDYKTKQDEFEQTQKKMKIAQRRPEDQFESNLSYHRHRLMRGMVDNPHCEVTDIEDGPQFVMCTQGTPPDLSVFGMALDEEEEIEVVDTSSIRNNCLQLPNGEESCFNLSAGLRRSYTTFFTRGSAPPLPWNRVDWPSDADCQNVPHELPDWSKYAPTHFPPENKGLRVSHLVNENLNLFKDDIHPLPWFPPVCVTVEELKDGSTAMDYVDSITKRGEIPLTDTIKSLSPQLLAYVNSDQASEEELSQRVLTAFEEPKNANEKWLIFNLAGFYWLMIGNNYHGIECLRRALHRAPVEYADVPLVNAASVLLNARRAEDAVQLLRMALVVNSTEPITHFVLANALAASGNLDAAANEFAVALTFNPKDQYLNTLKQLKCFQKQEELTARQAHDEEVDAKGQRLQQRQSRTVCSQGSKGERQCQTETRTREFVPRETGDYSKGEDKRGEKPRKAAGTPLHNSPSQDGDEGESFVSVDMVTHPPGINVDQSQVVNLETTLQPGSVLKLNFKDGELQDSELVPPPASGPNIPAAKPSPTVDVSDLNNLTRLPWPTLHDCQMYKKVNLNMFYTTWVSVTAKNVKIEEHIDFQAKLPSKSLEPVCEADVGTSMHTLDHLEGMAGREELQYTAEQGLDEALEFMRSEDKPMSITVAGKRIALALRKNSTSWVLTNLAAVYWRRAGNAVNALNCLRVALHYSDYKVKDLALISIANIFHRSGMIDNGITVAQMAWEISSEFVLCHFTLANLYAAKRQFDKAIQLYESMILFNTSFSPAEERLKTIKCAVLQMTKGNPASMLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLU2</accession>
    <name>A0A913ZLU2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052737.1">
        <property type="nucleotide sequence ID" value="XM_038196809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196809.1">
        <property type="protein sequence ID" value="XP_038052737.1"/>
        <property type="gene ID" value="LOC119725404"/>
    </dbReference>
    <dbReference type="GeneID" id="119725404"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119539" checksum="610B32CFDD4F6F12" modified="2023-02-22" version="1">MDVSQVPEKKANTLKEEHQQSEGGWHGLSSAQKRMVMMQQAAPESTAYVETIAVRTTNQIEPRDVFKSLTSLHPILTSKIDMDGERQEFVVPLGSNVAFDVKPEVLDADNDVEDYIKQSTPVMDIFHEPLVQYRYCIQGENHILVLHIHHLIVDIVTIINIWKDIHGLIEGASNVKGAPVSATSYSSFVAWESTERQSARHGADQDFWKETFSSMPTRASLAVLPLSECEWSDASVYKARQAKIILPRESTESISKYCQSIGVTPFKYYLACTMLVYQRYIGTEDVTLAVPISTRPQAHQNTDGLFVNTVLFRKVLRTDMTFTDYVKDVAKSWMETYSHSQYPLEEVVKIVKEAHGMSMSSFCCMMLGSYTMQTSNVMRIPAKHAKMPVEFDVIFKRGEETIEIVVNWAEEFIDAGVAQRLAEGVVHTFCKAYQQADDITQSIQVLSSAELDLLESFGRHPGESQTIPEQPVHVAFEEHAVKNPELIAVSCRDVSLTYKQLNIMASSIAQGLLENTDQVTLQKRPVVIVMQKDEYTVASVLGIWKVGSHFLPVGVSNQNSLKGIFERCEPAAVLYNTRLKDLSIPTTKQCPVLNVKDLTTYPADDMVQSRLVGNTPVDNLAYVIRTSGSTGIPKQCSISHRSLGIIAAASTKMYNLPDMTVNCLQWAPISFGVFIADLVRALVSSPGRLTICPDEFRLDVFHILDLIHEQNVTLAEFTPQFARQLVENAKLDQLESIQLLILGSDVLQVHVYSRIKDLLNPNQRVLNSFGMTEATFDSSFFEGPVVSRTRSGMVPIGKPFPGVRFHVLNPSTLQPCPVGTVGELYISGDVLASGDAELVHLEHLQCVALKTGDAAYWLPTGDMDLMGRLNSMVKLRGFRISTKEIENKILQLVPGVKAACVVPMTNSEESGSTDQSLCAFVVLDESSQTGGIEIDRRSVCQKLQSDLPNYMLPNIVSIIDEVPLTLNGKVNYKILRSINDVVKMETEKETTDNTVETKTASTLRMLLAEAMGFPDSSRIPSDTTFMELGAHSLVLVRFSVLLRRKTNFDVKLTDLSDYTSIRSLADFIEQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLW4</accession>
    <name>A0A913ZLW4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052757.1">
        <property type="nucleotide sequence ID" value="XM_038196829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLW4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196829.1">
        <property type="protein sequence ID" value="XP_038052757.1"/>
        <property type="gene ID" value="LOC119725423"/>
    </dbReference>
    <dbReference type="GeneID" id="119725423"/>
    <dbReference type="OMA" id="SYIFIRG"/>
    <dbReference type="OrthoDB" id="10020495at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="134"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="352"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="822" mass="88902" checksum="8DDABE56B3A8508F" modified="2023-02-22" version="1">MYGSGIDSLRIYQRPADVFSHPNLELLIITGQQSTEPMWLHREVNLTEVSYNFHIAFKTTEGTSIESDVAIDDVELISPEISTTDSSIVTTKEATTTRQIDVQSTTGSTTELVGSTESQPIDQTSAIDSTGVDFNCAFEGTFCGWTQPAMAFDVDWVVQQGATPNANTGPEVDRTTGTISGAYVYYDGRSYTADGTATLKSPELNSRFSNGKLSFWLNMYGIGIDSLRIYQRPVDVFSHPNLELLIITGQQSTEPMWLHREVNLTEVSYNFHIAFKTTEGTSIESDVAIDDVELISPEISTTDSSIVTTKEATTTRQIDVQSTTGSTTEHVGSTESQPIDQTSAIDSTGVDFNCAFEGTFCGWTQPAMAFDVDWVVQQGATPNANTGPEVDRTTGTISGAYVYYDGRSYTADGTATLKSPELNSRFSNGKLSFWLNMYGSGIDSLRIYQRPADVFSHPNLELLIITGQQSTEPMWLHREVNLTEVSYNFHIAFKTTEGTSIESDVAIDDVELISPESSTTDSSIVTTKEATNTRQIDVQSTTGSTTEHVGSTESQPIDQTSAIESTAEATTAGQIDVQSTTGSTTELVGSTESQPIDQTSATDSTADSATTESQNAVTTETTAAGQIDIRSTSRSSTELSGSTESQLIDQTSAIEATAGTLTPKAPIVSSGSSSTEAGRDRPSTTRSGNMVFTTDVGIEPPTKEFSVQLRILEVDGIPVAYQDQYQDKTSQAFRDLSIYVQNAVFRLCRRFETTSDIIRFEVVSVRSGSLLVNAVAQYPINSAIVSDTILDVLRSDAMSNNGRIDNALTIDLSATVVAGRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMM1</accession>
    <name>A0A913ZMM1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein assembly factor 1, axonemal homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNAAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053053.1">
        <property type="nucleotide sequence ID" value="XM_038197125.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053054.1">
        <property type="nucleotide sequence ID" value="XM_038197126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197125.1">
        <property type="protein sequence ID" value="XP_038053053.1"/>
        <property type="gene ID" value="LOC119725644"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197126.1">
        <property type="protein sequence ID" value="XP_038053054.1"/>
        <property type="gene ID" value="LOC119725644"/>
    </dbReference>
    <dbReference type="GeneID" id="119725644"/>
    <dbReference type="OMA" id="EARMPRM"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000166">
        <property type="entry name" value="Dynein assembly factor 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000331">
        <property type="entry name" value="Dynein assembly factor 1, axonemal homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70400" checksum="16DCA53F0EA8C93B" modified="2023-02-22" version="1">MPVIVELPDDPKPTPGGLGSKVTTDEQPPPLGDHPLTQPTEVSPQKKTLTDKPVFITESTEDVGSNAGDATKQQSPETEIKPKEEAKTKESQEKKEDNDYPRITEKSLKEHCKQHKLYRTPELNDVLYLHYKGYQQIENLDKYTGLRALYLECNGLRVIENFDHQTEMRCLYLQQNLIKSIGNLEPMQKLDTLNLSNNQIDRIQNIACLTKLNTLNMAHNRLTTADDIRELAACENLSVVDLSHNRINDPEIVDVFAAMKTCRVLNLMGNPVVKRIPNYRKTLILKLTNLTYLDDRPVFPRERACTEAWFRGGREAEKEERERWINKERANIQASVDALTQIRKRTQANRQETEDASKKEPASSPEPVTTPPEDEHLFTFDVSKAPSSGQRAKTGMLIEEVSSQDSSSVQKTSSDITTELVDEDDLETIDLPSEEKINIDDLPDLEDFDTMDDVASAGPRKMLIEEIPSAEPPNGRVMISEISQSQGDAKNTSQSDSSLLVTEEPDDQSHPLVENLSQSGNKSKSLIVEMDQSKTESPKMDQSEGADSVTSSGTANKVSLIEELKEFGARIPNSWHVIENEKLRKEQENDKSNGASSTSSTTEKSNEEKIWDLAANAGSTVDRPDPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNW1</accession>
    <name>A0A913ZNW1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052731.1">
        <property type="nucleotide sequence ID" value="XM_038196803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196803.1">
        <property type="protein sequence ID" value="XP_038052731.1"/>
        <property type="gene ID" value="LOC119725399"/>
    </dbReference>
    <dbReference type="GeneID" id="119725399"/>
    <dbReference type="OMA" id="INFEMEQ"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="417" mass="45439" checksum="F2DCBCD87CBB067C" modified="2023-02-22" version="1">SSAAALCYAELGSTIHKSGGTYTYILQAYGDLPGFLVSWANVLVINPSGSALNALTFGTYVSEYVTPGECLPPSVVTKLFSILAMMLCVFINCMSVRHSASAQVAFTTSKVLILVIIIGCGIVKMIQGETRHLDPSVSFEGTSADVFGYGTALYQGLWAFAGWDVLNLLTEEVKNSKRNIPLAICISMTSVLVIYLFTNIAYFTLLSADEVLASNAVAVTFAERVLGPMAWIVPLGVCISTFGNLLSGLLAMPRNAYVAGREGHMVKALSMVSVTRHTPLPSIVFQGTIATIMVSIGDFNSVLNYFSFAAWLFFGFGFLAIPVLRYRFPDHHRPFKVPIVLPIAAAIFCLFMVLAPIISEPTLAYLYLVAILMGIGVIFYVLFVWKKYRPGFMDAVSMFIQKMFLVAPSSYLEPDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQI5</accession>
    <name>A0A913ZQI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053957.1">
        <property type="nucleotide sequence ID" value="XM_038198029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198029.1">
        <property type="protein sequence ID" value="XP_038053957.1"/>
        <property type="gene ID" value="LOC119726374"/>
    </dbReference>
    <dbReference type="GeneID" id="119726374"/>
    <dbReference type="OMA" id="DYECKEV"/>
    <dbReference type="OrthoDB" id="2575524at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041606" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1203" mass="123597" checksum="78754D067741F041" modified="2023-02-22" version="1">MKNTVATFLLLLIAEKVALAGRTRTVDGTDYECKEVEAVCPGELIFTGLVCGSNSITYPSKCDLVREVCTRDTYQTFEFSHLGPCTDADCPSHCRGEGFHYVCGITGCRERTFRNFCHLKKVSSACKPERRIPLTFSYKGFCRNPGRRISNCTDVEIMQPTDKDPAVQTEIPEDIKLQTDAPKTPTDAPLPLTEKEAEPTASVETTDTPVKPTDAPVKPTDAPVEPTNAPVEPTADPVKPTDAPVQPTHKAVEPTDAPVEPTVASVEPTDAPVEPTSVPVEATDAPVKPTDAPVKPTDAPVEPTAAPVKPTDEPVQPTDKAVEPTDAPVQPTEALVEPTDAAVETTAAPVELTNAPVQPTDKAVEPTDAPVQPTAAPVKPTDAPIEPTDAPVEATAAPVKPTDAPVKPTDAPVEPTDAAVEPTAAPVEPTDAPVEPTDKAVELTDAPVQPTEAPVEPTDAAVEPTAAPVKPTDAPIEPTDAPVEPTAAPVEATDAPVKHTDAPVKPSDAAVEPTDALVEPTAAPVEATDAPVKPTDTPVKPTDAAVEPTDAPVESTTAPVESTDARIEPTDAPVEPTAAPVEATNAPVKPTDAPVKPTPVEPTNAPVQPTDKAVEPTDAPVQPTEAPVEPTDAPVEPTAAAVEPTDAPVQSTDKAVEPTDPPTDGKKVDTMQTTQGPVQATDAPVQPTEAPLEPTDAPVESTTAPVESTDARIEPTDAPVEPTAAPVEASDAPLKPTDAPDAPVKPTDPAVEPTAAPVEPTDAPVQPTDKAVEATDAPVKPTDAPVKPTDAPVEPTDKAVEPTDAPVEPTEAPVEATDAPVKPTDAPVKPTDAPVEPTDASVESTAAPFKATDAPVKPTDAPVKPTDAAVEPTDAPVELTEAPVEATDALVKQTDAPVKPTDAPVEPTDAPVEPTAAAVEPTDALVQPTDEAVQPTDAPVEPTDGPVEPTEAPVEATDAPVQATDAPVNEAPVEATDALVKQTDAPVKPTDAPVEPTDAPVEPTAAAVEPTDALVQPTDEAVQPTDSPVEPTDGPVEPTEAPVEATDAPVKATDAPVKPTDEAVQPTDAPVEPSDGPVQPTEAPVEATDAPVEPTAAQVESTDAPIQPTDKAVQPTDAPVEPTDAPIEPTDSPVEPTEAPVEATDAPVQPTDAPVKPTDPAVEPTAAPVEPTDAPIQPTDKAVEATDAPVKPTDAPVKPTDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR87</accession>
    <name>A0A913ZR87_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053899.1">
        <property type="nucleotide sequence ID" value="XM_038197971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197971.1">
        <property type="protein sequence ID" value="XP_038053899.1"/>
        <property type="gene ID" value="LOC119726315"/>
    </dbReference>
    <dbReference type="GeneID" id="119726315"/>
    <dbReference type="OMA" id="CENANGT"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="845"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="266"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="664"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="847"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1165" mass="127562" checksum="28B8C9ABE08BCDE9" modified="2023-02-22" version="1">MHSDIDDCEPDPCLNGGTCSDGVDSYTCTCAPGYTDSRCSSDVDECLETPCSDTATCVNQPGGYSCVCPAGYLWNGTSCDDMDECEQESSVCPSTSPCQNTMGSYTCICTEGYGWNGTRCTDVDECQSSEPVCPSLASCTNIQGSFRCHCQDGYTLTGQLGSSLFFCMDIDECQDEALYDCHSNATCTNEPGAYRCMCSEMQGYRGDGTVCTPFDLCESGPCLNQGQCTSSVGSGSYECVCTEDFTGVNCGIRVVPQGPISVLKHPEPSLITASLYYTVTLECQFENANRFAWYKNGAMLPGTRDVSFLTIAGVTSTDRGYYWCEGSGLQGVTLQTNASLLLIDGVFAFTTEARFPTLTFVDELRNKSSPIFKQISAEIITFLSEGLQSEGVQANIAVKELNSGSVVATTEILTIAGGTNSDDSELLSIVQDALVGIATASDGYMDPSSIILESSGSCVETRWPTIYGTITLPAVPLGEDTVSNSDRVCPDYTINSGQPIAYAVCVGDGFSPAHWLVELQCGRNLTVDEKLALLNRVEVNDENVMVVALQVMALTEDAEMLTDAGVASTADIMTKIANLNSSSSQVTETVVDTVGNMMFISDEVLREAEVREHAPSRIVRVLERQLGEVSLAGNVSFREVHPNIAVEVRGVTESTLLNGLGFASANSSSSGLFGESSLMVMEGEDELFQGASESEMPSAVLMLPPEVNILARREVGGGIRVSFSVFRKQNLFQSPSLADFNKGEDRFNRTINTRVMSATVGSQPITNLNEPVTILLSRIDNDSYVDNTSCVFWEFDNASWSSEGCRLREEYVTDQYIACQCDHLTNFAALMDIYPESPLTETQEFILKLLSLVGCGMSILGLAVTMVTYLSHEKLRKIRPNRILLSLCASLLCLYITFVVATALDSERGVAELDVLPCCVLAGFLHYFTLTSLCWMGVEGFNMYLLFVRVVNVYVPKFMLKALLVAWGIPALIVAITAGATREDYVGTDFCFLKQIPLIAGLLAPISLILLFNIVVFSLVIHQFIKTSNNDLRRNRDDISKRKLHKQRLQNALTVMTLMGLTWSIGYLNLVQAISFPVQLVFCLLNTLQGYFIFMFYGVRRAEVRQHWRRCCVFQRATFSSVRTSSQTQSWTNKPQVRTPFNPNMIPRPPSQIYRHRPDSMMPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTB3</accession>
    <name>A0A913ZTB3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054679.1">
        <property type="nucleotide sequence ID" value="XM_038198751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198751.1">
        <property type="protein sequence ID" value="XP_038054679.1"/>
        <property type="gene ID" value="LOC119726900"/>
    </dbReference>
    <dbReference type="GeneID" id="119726900"/>
    <dbReference type="OMA" id="LCTYCID"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="590" mass="66242" checksum="78508DEABF89E17E" modified="2023-02-22" version="1">MASNVTAQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLHDLRQSQDPSGTKLTCPLCRRETMLKESGVADLPNNFAFSALVEEVTMQEKLLEGQGSDIKCQNCDEENQAISRCADCDHFLCQECQKAHGRMTVMKSHKIYTLAELRSGEIVYKSKLRDEVPKCGKHPDQNLNVYCNTCEQVICLMCTVLDHEKPKHSFIGLPEAFEKCKKKIEELVAKVGKSKTELSTTIEKTCISRKKLDIMFANTKKKISEKADQEIAKIRQEEQKLLKETDRIYKERVVKFEAAQANNSKEVTQTDHKLEEVRQLMNQASCCEILELQQKLFHNLSELTGKQPQQVPDKLSFMDYEDDERSLGRLILEEEPQAAAKQSPRPARSCVKEKWDLKTEVKNLQLTNALIADVAALSGNKIIVLFKNTYSGHSCALFTASIPNSHLEQSLIPQRLQINGLTNAIRCIAVTKDDKLLALDGRVVKVFNKQHQLLHQCMTKRLVCVDYYGASAFSVDMTSNKQGGWCPTVVCCDSDGSIYVAVYGHPPSNILYYSPDGKYIGCAIKGSGPLRGITFTPNGDLVVAVGHSVKVYHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTU6</accession>
    <name>A0A913ZTU6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055022.1">
        <property type="nucleotide sequence ID" value="XM_038199094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199094.1">
        <property type="protein sequence ID" value="XP_038055022.1"/>
        <property type="gene ID" value="LOC119727229"/>
    </dbReference>
    <dbReference type="GeneID" id="119727229"/>
    <dbReference type="OMA" id="AINWICG"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF196">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="227" mass="26108" checksum="07458F793BF69BF6" modified="2023-02-22" version="1">MTVWQWYSRNAIRIQIVFLILVSLCWIYAKKCNFSRCVFQGAFFGLIIGFLIGATRLVLDFVYGLPSCAQPDERPGVLRNLHYLHFACVLFAISLLVTVVVSLLTKPIPREKLIRLTWWTRHSSQARQPIEENQRANGNYEMVEKGSPKNKDEEIEVEVSIPRRAWYWLCGMSGGHQTAVMEMTPEEREDADKKMTSIAEDPKWHRVAWINALILTAVGIIFFGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTV3</accession>
    <name>A0A913ZTV3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054640.1">
        <property type="nucleotide sequence ID" value="XM_038198712.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198712.1">
        <property type="protein sequence ID" value="XP_038054640.1"/>
        <property type="gene ID" value="LOC119726858"/>
    </dbReference>
    <dbReference type="GeneID" id="119726858"/>
    <dbReference type="CTD" id="1362"/>
    <dbReference type="OMA" id="CCKYPPG"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03868">
        <property type="entry name" value="M14_CPD_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000026">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000004">
        <property type="entry name" value="Carboxypeptidase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1633"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="65"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="472"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="875"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="1246"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1725" mass="192288" checksum="758500008CAEA687" modified="2023-02-22" version="1">STYYQQTSSYSQTRHGSDFSVDMALFTATKSLIILTILTILLFCLSTEGRLSHQRLQEAQVDTSNYHKHAQLTSLMHQYATDYPTIXKLHKVGSSVQGRELWALQITDRPXEVEPGEPWFKYVGNMHGNEAVGREILIFLIQYLCQSYGIDDRVTNLIDSTNIFIMPSMNPDGFESATEGDCTSASGGRQNAHNKDLNRNFPDQFRSKDPPQEPETSALIKWIESYPFVLSANLHGGSVVASYPFDDSAQHKRSGVYSSSPDDKVFVMLAKAYADNHLTMSRGPAECYSGESFPGGITNGAHWYDVPGGMQDYNYLHSNCFEITIELSCCKYPLASQLATEWNNNRESLLAYMEMVHRGVKGFVYDAVQHTGIPGTRIVVDSILHDVTTAQFGDFWRLLTPGTYTISAHADSYRPGDAQTVVVTDGEPVELEFFLVPEGSEDLLDLKAKQSGDAEQEINEEEEDELEPVVFEYHHYEEMKTFLQAYADRYPHITSLYSIGTSVQGRTLYVMEISDNPGQHEPGEPEFKYVANIHGNEVVGRALVLNLIQFLCENYDRSAEVTALVDYTRIHLMPSINPDGFEKAHEGDKTGVMGRNNAHNVDLNRNFPDQYGSSEGKLQPETRAMMQWIRSYPFVLSAGLHGGSLVANYPWDDNKPGTSGYSKCPDDAVFIQITEAYSMAHTTMHRGHPCPNLYPNESFKEGITNGAEWYSVAGGMQDWNYLHSNCFEITLELGCVKYPRTRDLRSYWNANKVAMLALIEEVHRGVKGFVVTPKGKGIVNATISVAGIDHNLLTAVDGDYWRLLVPGTYEITASADGFVPQTQTVTVQEEWAVDLNFTLVHSGETAPDKTPLNTALSDQEWAQTFDFGLPQDSADYLSNEALAAKMTELEAKYQSSGVLRLLPLGATAANQAVTGAILTNPGAEEDVSDMPRVALIGGLRGDEPVGREILWRLIRHLAEGYERGDSVVTQILNQTSVVIVPAIDLDGFDHSQQGDCQGEHFTGESFDHAFGPNGKMMSTRPELTMVKNLLTTTQYSLVLSIEAGGMWVRYPLDTSVAGNELAQGAVTEDDDLLSYLASTFALDHPTLHTEVNCHGRRFQAGIVRGSDWTPRQNSLQDYMYLKQRAYMITSHVSCCKYPDHTALQSLWRENLEPLMGFIRQAQQGIHGTVQDNKGMPLPGATLALVGHTRNIALSGQTASFHRLLPPGDHVIMAEAPGFMPITKHINVEKNQMQKVIFKLQKPIDMVYHNYDAMEKYLRQLATRYPDITHLKSIGQSADFRQLWTFEIGKHPGHHTPGRPEVKFVANVRGNEPVGRELLLGLADYLLRNYGNDDVITKLIDKTQIHLLPNMNPDGSEAAWDTEGTCNGKVGVGNSHHVDLEQDFPSVVVNRSVADLQPETRVVIGWLQSRPFTLSVALYGGTSVVRYPYTANHHPAYASRNLPNPTLDDDVFVHLAKTYANLHPTMHLGNPCPNDTTTGFQDGIVNGAAWENYDGSMQDYNYDFIKCLEIAVATGCCRYPTQPVLQRLWDDHRKPLIEMIQQAHHGIKGFVRDIRGQPIVGAKITVEGRGHRAESSPEGDFHLLLLPGTYTLMAEAEGSGTQTRKCTVGDVDFEAVLVDFEMEETKEILGLPPIMFIGVTVVGVMLLILTTVCLVYVCRSSTTGRRKQGFYRLDGEKMYQEEYNDRIALKGFNSTSKRPLLNNVEYHDFLDSASDDETMFTRNSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU70</accession>
    <name>A0A913ZU70_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055273.1">
        <property type="nucleotide sequence ID" value="XM_038199345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU70"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199345.1">
        <property type="protein sequence ID" value="XP_038055273.1"/>
        <property type="gene ID" value="LOC119727459"/>
    </dbReference>
    <dbReference type="GeneID" id="119727459"/>
    <dbReference type="OMA" id="YRIACHA"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054599">
        <property type="entry name" value="TFIIIA_Zfn-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF20">
        <property type="entry name" value="TRANSCRIPTION FACTOR 3A PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22110">
        <property type="entry name" value="TFIIIA_zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="38757" checksum="95C744DFDE0D31EC" modified="2023-02-22" version="1">MVSSACGLTGSSEKDGKKRDFLCTFGGCDNAYTRKIHLQRHLASHSDKRDFVCLEDDCGKSFTNNDILKKHIRRIHRERIFKCNYEGCDKTFKKHQHLTVHGYIHTNVKPFKCQYEGCEARFKVPSKLKSHAKIHKGYTCDKEGCGRHFDKWTGLRKHLSEDHITEYKCEKCGKTYHKRHKLKVHVKSHEKLREVFMCPREDCDRSYLKASYLELHVKNYHDGGRPYACDHAGCSKTFIHKGSLSKHQVVHKPDYVKPPPKPRKKRGLASHLSCYPDEATRPRPHKSSLETLSGDEEVAQGNTSLKMVQEAVTLGEKSEDAVAMEISVSDSGGNVEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVF9</accession>
    <name>A0A913ZVF9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055479.1">
        <property type="nucleotide sequence ID" value="XM_038199551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVF9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199551.1">
        <property type="protein sequence ID" value="XP_038055479.1"/>
        <property type="gene ID" value="LOC119727601"/>
    </dbReference>
    <dbReference type="GeneID" id="119727601"/>
    <dbReference type="CTD" id="54726"/>
    <dbReference type="OMA" id="GPEANIS"/>
    <dbReference type="OrthoDB" id="10017659at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20380">
        <property type="entry name" value="Tudor_TDRD13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049770">
        <property type="entry name" value="OTU_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF115">
        <property type="entry name" value="PROTEIN OVARIAN TUMOR LOCUS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1102" mass="123642" checksum="CDBB8A48521B30DF" modified="2023-02-22" version="1">MRRFQRIIEPIDDYLSSIGLYRKITAKDGSCLFRAVAEQVFHTQAHHLKVRDACVKYMENNRDRFAPFVEGPFDQHLVKLKDPKEWAGQVEISALSLMYKRDFFVYQEPGIGAFNVTQNGFTDKIVLCFSHGSHYDSVFSKKFQENAAICQSIIYEILYKDVFKLSKQVDEAVDILRSSNKKPMRRDGHYGPDGMRDGRGMDGDHMGMDRDGRDRFGRYHEEKKRPPLPYRVAKALDPEIYRNVEFDAWNEARKEQQHQDYLVASVLQYAPGDKCQVFLDDPKKLYNAHIQDVQPNNGPVTVFIEDLGEKHTVPMKNLKPVESLSPRRPWSPLGVRSYKNLNGYFQKYANGVNNESGYNQPCHQQQQLQQHPSFVHPLMQQDRQHPRSTSPYQRGRGGGRCNHTMHNAMSQEEYDEKRALEESLALFELQERDPASFPSLPGHSTGRINSASPVNLWDKFRKEGRKSASPIQRINTPSPVAMFEGRGPVHGDGMQGQFQDMSLHDNDRADGHGMPNSGKMQLNKEVYQPPHQPSRENAGTPHTNQSPGTPKWHSSNSTLSTSGSNACPSAGNTPSPPAVPMIPSYNAPMPTLPGWIPLYPLVIPITENLTGPVNASATASRDPNGYDLPLSDVSTLRYYYNLGVEYHHRLCLLQMHQWQQQQQQQQQQQQSFHPPQDPSSCPIVSQAQQQQQPAMQTSSASNHFSPEGAMSANNNALDDDTEEGMRQRSCTPNGLQGMTVNTIQQPTLSPSGVKQNGTLCPNVIRQPVLHQQQQQQQQQQQQQQQQQQRQQQRQPFLPLPVNAVYFTFPPRDVGFSLGSTQPSNSLPGHEQREQNGRQSPRNVPLRCMNGQPMQQQQQNTDNHVVSEFKPDTEANARSKPASFVTPMRPSMPLRIPTPRSEDRSVNNIPSHIPGSQSPSSCLPACPLEIQASSGPAPRNLVTPTRRKSPFDIVSPGVFPMSPFPVLNNTNITIQPPVLSQTGPTQPYYIDSQANQHIPQQQQQQLQAPAPVSTFFSPHANPPAIQSEPYPHMNYHPAPPPPPPPPGNLGTYQYPVQGQWQPAFPYGSPVKVPTVAYGQSPPVTFMTSNAPSSAPALYMPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVJ7</accession>
    <name>A0A913ZVJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055096.1">
        <property type="nucleotide sequence ID" value="XM_038199168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVJ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199168.1">
        <property type="protein sequence ID" value="XP_038055096.1"/>
        <property type="gene ID" value="LOC119727314"/>
    </dbReference>
    <dbReference type="GeneID" id="119727314"/>
    <dbReference type="OMA" id="CYRKYNI"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029776">
        <property type="entry name" value="TMEM179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25781" checksum="8C5C4E9461BD4005" modified="2023-02-22" version="1">MPTVSLPDRPSPFTFGIIVELIFLCGTFITGLVIAGAVGVTQARWNGKCILSMGVTCTMGTDLKWHYSFTSDGGLCHFCLNFQIACVLTSFVFAIYRILVLCYRKYNIAILRLVTAGIFTVYALLVLAEAAIITIGLNAFCDGLMNSCGVSFGKTCPQYQTWIDWIYDDGSSFYSTTLVAEVAAWISFVFWVALAVWSFVLFLKARRANRQMVLPPSSLTTPAAAAAPSTVTNKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW85</accession>
    <name>A0A913ZW85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055918.1">
        <property type="nucleotide sequence ID" value="XM_038199990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199990.1">
        <property type="protein sequence ID" value="XP_038055918.1"/>
        <property type="gene ID" value="LOC119727912"/>
    </dbReference>
    <dbReference type="GeneID" id="119727912"/>
    <dbReference type="OMA" id="YDNHYDD"/>
    <dbReference type="OrthoDB" id="9885288at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="135" mass="15744" checksum="957611D005672AE6" modified="2023-02-22" version="1">MQRLLWLNSPILEWQSCCKLHRTLRLKSRMSVRRRYGFFKCPTCNRRWESAHAWCDRATDKPSSGQQCKNAGCPRDYIKPYKDDDDDDGDDSDGDDDDDGDDDDDDDGKRHNNPERPHLSDLCEMCQKGDACKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWQ4</accession>
    <name>A0A913ZWQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055735.1">
        <property type="nucleotide sequence ID" value="XM_038199807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199807.1">
        <property type="protein sequence ID" value="XP_038055735.1"/>
        <property type="gene ID" value="LOC119727762"/>
    </dbReference>
    <dbReference type="GeneID" id="119727762"/>
    <dbReference type="OMA" id="FMHNITN"/>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="330" mass="37840" checksum="3F88D1A605D61B03" modified="2023-02-22" version="1">MVEWETISELIIGLLGIAGNFLVCLSIIRAKFMHNITNYILLSLAIADFVVCLNILIFNKYVLDVGDLDFHPSSPLVGEILCQLFDDKILVWWSSKTSVMHLMFVAIERFVAIVQPLRYKRYFTVRRLIVLFVAMWLLSLLLQLPYMLTPDFNPDTSQCDRPRISTFSRIFYVFTNFLFIIIPSICTLWCYWRILKCLRTSARTFLEENNRGPGLELLYACRKVVQTLFIVYVAFIILWFPNLILGIIYSLPVTTLSTPPGLNTAFKLMAFSNSVVNPFIYGFKYRQLRKAFKVAVMPCCCNTEVNPNPGSAPYELSVLRLQQGSNNGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX53</accession>
    <name>A0A913ZX53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056099.1">
        <property type="nucleotide sequence ID" value="XM_038200171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200171.1">
        <property type="protein sequence ID" value="XP_038056099.1"/>
        <property type="gene ID" value="LOC119728095"/>
    </dbReference>
    <dbReference type="GeneID" id="119728095"/>
    <dbReference type="CTD" id="25821"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="518"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="600" mass="66550" checksum="4A9FFF6754092033" modified="2023-02-22" version="1">MSCNPSFGGIGKGHLMREVDALDGLCARIADRAGIQFKVLNRRKGPAVWGLRAQIDRDLYKRHMQEEILNTPNLTVEASSVEDLIIGDVQAEREGTTAGKGCHGVILKDGSHVSSRAVVLTTGTFLRGVIQIGIDERPAGRLDDEPTIGLAKTLENAGFTLGRLKTGTPPRLDGRTIDYSQLEKHRGDAQPTPFSFMNDRVTIKPEDQVVCHLTHTTPGIGPIIMENKHLNVHIKETVTGPRYCPSIESKIFRFGMDKCHQIWLEPEGLNTDTVYMQGFSITLPADLQDQCIHMVKGLENVVMTRPGYGVEYDFMDPRQIKSTLETKRLQNLFFAGQINGTTGYEEAAAQGIIAGLNAALLARNQPAFSVSRTEGYIGVLIDDLITQGTSEPYRMFTSRSEFRMTLRPDNADQRLTGRGYEAGCVSCHRYQRAQATADRLQEGMEVLQSVRLSRSKWRQGMEEQRVQTPLTEASPGKISAFEMLAYPNVTLAHLAAVSPDLKTYADDESIAMRLKVEGIYAPLLRQQQCDIDQVKRDESLVLPADIDYDSINISREAIAKLSTVRPQTIAAASRIEGMTPAAVLQLLYHVKRRERQSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXE1</accession>
    <name>A0A913ZXE1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038056217.1">
        <property type="nucleotide sequence ID" value="XM_038200289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXE1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200289.1">
        <property type="protein sequence ID" value="XP_038056217.1"/>
        <property type="gene ID" value="LOC119728182"/>
    </dbReference>
    <dbReference type="GeneID" id="119728182"/>
    <dbReference type="OMA" id="YVINFAL"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.130:FF:000001">
        <property type="entry name" value="Vitamin K epoxide reductase complex subunit 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="19207" checksum="6A4DD1D4D440870E" modified="2023-02-22" version="1">MGNPSTSTASKVQMPMSHMLARWGLCLVGTVLSIYALYVETSKESNPDYTAMCDIGKSISCSKVFTSKYGRGFGIVGSILGERHILNQPNSIFGILFYILQVVIGQTHTLSATNFLIMTSILSNFGSVYLAYILVVVLEDACLVCISTYIVNALLLAVNILKWTHLRRTLTKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXF2</accession>
    <name>A0A913ZXF2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A913ZXF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200395.1">
        <property type="protein sequence ID" value="XP_038056323.1"/>
        <property type="gene ID" value="LOC119728240"/>
    </dbReference>
    <dbReference type="OMA" id="VACDAWM"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="107" mass="12057" checksum="62980EC59A6199AD" modified="2023-02-22" version="1">MLPLSLLRTAQNHPMLVELKNGETYNGHLVACDNWMNINLREVICTSRDGDRFWRMPECYIRGSTIKYLRIPDEVIDMVKEEVVAKGRGRGGSQQRGRGRGGPGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY17</accession>
    <name>A0A913ZY17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome RNA helicase MTR4</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Superkiller viralicidic activity 2-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">TRAMP-like complex helicase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038056379.1">
        <property type="nucleotide sequence ID" value="XM_038200451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200451.1">
        <property type="protein sequence ID" value="XP_038056379.1"/>
        <property type="gene ID" value="LOC119728278"/>
    </dbReference>
    <dbReference type="GeneID" id="119728278"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000004">
        <property type="entry name" value="Superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="127"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="354"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1024" mass="116208" checksum="FD8E170A344FF89D" modified="2023-02-22" version="1">MADAFGGDLFAVFEERDDQSTKKRKHNPASNDPESSTSDSSKHPRGDDHEVPEYTTGKKPKLALTADELNLAEILPQVKSQTVESIEGCTHEVAIPHDEEYVPLKPSGNKAAKEYPFILDPFQKEALKCLENTQSVLVSAHTSAGKTVVAEYAIAMSLRDKQRVIYTTPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLIMTTEILRSMLYRGSEIMKEVAWVIFDEIHYMRDKNRGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVVYTEYRPVPLQHYIFPAGGDGLHLVVDEKGEFRQDNFGAAMSVLRDSGDAAKGDSMNRGRKGGTKGPSNIFKIVKMIMERMFQPVIVFSFSKKECEAYALQMSKLDFNSSPEEKAMVTEVFNNAIDCLSDDDKKLPQVENVLPLLKRGIGIHHSGLLPILKETIEILFSEGLIKALFATETFAMGLNMPARTVVFTNARKFDGKDFRWISSGEYIQMSGRAGRRGLDDKGIVILMIDEKMSPGVGKNILQGQPDALNSAFHLTYNMVLNLLRVEGINPEYMLERSFYQFQNYSVIPELFEKLKRLEDEYNQMEIPQEESVEAYYKIRQQLNKLGQEIKAFITKPKYALPFLQPGRLVKVKNEDDDFGWGVVINFRKKANQKMNTPRDDPLYIAEILLNCSKESIKNAVTESAKPPKTGEKGEMAVVPVLLNLITHLSSVRLYLPKDLRPLDNRQSVGKSIQEVQRRFPDSLPLLDPIEDMGIKDENLRRVVEKVEAFEERMYSHPLHKSPDLQKLYSQYEQKAKIASEVKAAKRELKRAKTVIQLEELKCRKRVIRRLGYATVADVIEMKGRVACEISSADELLLTELIFNGVFNSLKPEQIVALLSCFVFEEKSKETPRLSEQLSGPLRQMQDSARRIAKVSSEAKLAVEEEDYVESFKPQMMDVVFAWANGSTFAEICKMTDVFEGSIIRCMRRLEELMREMCHAAKAIGNTELENKFAAGIVKIKRDIIFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZW2</accession>
    <name>A0A913ZZW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057165.1">
        <property type="nucleotide sequence ID" value="XM_038201237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057166.1">
        <property type="nucleotide sequence ID" value="XM_038201238.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057168.1">
        <property type="nucleotide sequence ID" value="XM_038201240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201237.1">
        <property type="protein sequence ID" value="XP_038057165.1"/>
        <property type="gene ID" value="LOC119728837"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201238.1">
        <property type="protein sequence ID" value="XP_038057166.1"/>
        <property type="gene ID" value="LOC119728837"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201240.1">
        <property type="protein sequence ID" value="XP_038057168.1"/>
        <property type="gene ID" value="LOC119728837"/>
    </dbReference>
    <dbReference type="GeneID" id="119728837"/>
    <dbReference type="OMA" id="LVNAAMC"/>
    <dbReference type="OrthoDB" id="9986749at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF15">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="320"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="409" mass="44532" checksum="D1479DFED14EBD79" modified="2023-02-22" version="1">MEDDIVCITCKQLALPGGETLEGKVHIIVEDGKISAIFDQEADLVKSTKTHYYADIVTPGFVDIHHHGLSGADDLVRFWSNPAYTQSRLIKYGVTSFLASMVFPKDLQSHSVFNTLKILEGIVGETGQGSTCEGIHAEGPIVNDFGGLPVGDNEMSIPDFKNILDAMPSCRIMTISPHVDAKNNYERIKMLLDRGIVPALGHDRLATEQEILGALKIKPSVQFHITHLFNVCSFHHRNPSLVNFGMTDRFPSLPGYEKLAPPTVEIIGDMVHVHPLAVSNVLSSRHFNQVAFVSDCTAEAIPNKKISYSNRDMTVTADGKCLVIEGTTTLAGSCCSCLDAFKSLVKMFHTGIGKAAAMVAENPARIANLKGIGSVKVGNRADLLLFDDDLNLQKTFVCGHPVYTAKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1T9</accession>
    <name>A0A914A1T9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057610.1">
        <property type="nucleotide sequence ID" value="XM_038201682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1T9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201682.1">
        <property type="protein sequence ID" value="XP_038057610.1"/>
        <property type="gene ID" value="LOC119729155"/>
    </dbReference>
    <dbReference type="GeneID" id="119729155"/>
    <dbReference type="OMA" id="VCETHPR"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08248">
        <property type="entry name" value="RTN4I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037397">
        <property type="entry name" value="RTN4IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83052" checksum="DBBC8FF56FC1C0D3" modified="2023-02-22" version="1">MRALFIQLGASASGSSLQLHNQTGFPDKTRHFPDLRLAPSYSTKFKMVVVDGNEDTKKIEGLCLFHFGPSNASQKVRACLEAKKLKWQSRVTCMTSEEMESDWYFTIHPQGLVPALVHDGVTHIESSDIMVYLDEAFPEIPLRPNTVDGRQAVQSWLDLERTIQKPMKYMTFRFYIGNFAKLIETDKRLARLKEKNPEGYAFHKMVREGSWNDEDLRGAIEEIHDALQILEGHLANHEWLVGDQISLADYCWGTNVYRYVESYMYRFPMGRYPAVRAWYKRLLTDEAFQKAVVAYGGGPPKPLLAIKNSIQEFLGNSISCFERDVKPNWARFVLMTVAVPLCFAFLPYASTTAATGLSSTVINTGLAALWASVLYSCYKKAHAATKTVYFSSVHRMRALLTKAYGSETPVVCEEHPRPKVVLPDDILVRVHAASINPIDVKIREGYGKRGLNFMRGKSQMPAGDGKELPLIQGRDCSGVVEAVGEAVSKVKVGDEVWASLSVAPIPGTYAEYVLLKEGLVSQKPSSLTHVQSAALGYVAMTTWGALVKTAVLGPDKTAGKRVLILAGTGGIGSFAIQLVKAWGGHVTTSCSTSGIEMVEKLGADEVVDYRKTDLESALKDKPRFDVVLDTLGPAYYQTCLNLTKRGGCVVTLDSPALKTLDQYGFLLGLPKALYDLFRISIPQKLFYGRSFKYGFVAASADALDVVASLVEQKKIQPIVEKVYSLEDGNEALGHVQKGHARGKTVLLMKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2G8</accession>
    <name>A0A914A2G8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058032.1">
        <property type="nucleotide sequence ID" value="XM_038202104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2G8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202104.1">
        <property type="protein sequence ID" value="XP_038058032.1"/>
        <property type="gene ID" value="LOC119729512"/>
    </dbReference>
    <dbReference type="GeneID" id="119729512"/>
    <dbReference type="OMA" id="STHARWP"/>
    <dbReference type="OrthoDB" id="10063844at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="946" mass="106117" checksum="5E96953C48E3C245" modified="2023-02-22" version="1">MGKTKPVAQRRTRSSAGDSSWSQFTKSCKCIMHDVFKTSESPKLFNIALKSHPTRKLQWLLDKKYLSPRAKHVCIDCLDQAPSTSGTGSKRDTTGKKDPSQLPEEEEPSNSESAIVGEILNLIANRKLSQESVTRVCSALGNLLSSDILQDSKAVQGSYKNLENLLDLNCVEYLGERPPALVSFLSSISNVTIDKDQQNAKKTNGLCLVIENIYALRNANFVGPLSFSQGLVKWSINGSKTTHALDGASSASGSVTSLKKVLQNSSAKSNVCFSSGDVDVFADNTQRIGKTGRVRTGGTTPANVVTNVVFIQSRPASNLQTQGQLAPSHWLDKTEDVADKITAFEKELNDNVFRPYRHMCQSKFIEQVKSELHVDDITGESKDHVYYSCSAQEQDCVCPKCCKVYDKVTVECPGCGYNPVNVPDRSSMYGDVPSCHSKEKPAVKMGEIIPINPNSKATIKEVLLNLKQQAGVGTDRSWIRVGFDGVPYRIANLLIKNTIMCEVCNEHIDISVTPFDAHCEIKHPGVYDIGSKKLLDDILLTPGAGHAEINLLRAIFSLTRVVFMEHIAGCLGFCSKRAKDFVIRGSNHHVTWQIFDIVLKAFALELCYTYVSQNREENENFLPTAEDFVMWKNTRVINPNFNLIYDLIFHIFLGVKCFRSGIRRNNSQHAIAGRQKTAPIMYIGKHGIYQPLLFRDMQVRVEAPPDIKKYIEENEAFSRSGNNLRGEGGDYVTENENRSLKSILPPGVPTVERWQMASRCSANLQKNRKAVFQRAGFQDPGEQRGSVFNRELEVQAIRKEIRLSGMLKNPYEEIPLKSIEGKLLHQDFVNVYNTALENYDAYKKSPHAPNLQPVFVTSEDEQMYNDMNNWTARKLTEETMKLLEQFSDQDSADMYREMHSDVAKAAKSVKIQFYQDISQILNLERELLAFGNEDIEQKDDDMEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2J2</accession>
    <name>A0A914A2J2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058068.1">
        <property type="nucleotide sequence ID" value="XM_038202140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2J2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202140.1">
        <property type="protein sequence ID" value="XP_038058068.1"/>
        <property type="gene ID" value="LOC119729538"/>
    </dbReference>
    <dbReference type="GeneID" id="119729538"/>
    <dbReference type="OMA" id="WSWRVRF"/>
    <dbReference type="OrthoDB" id="10016194at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031747">
        <property type="entry name" value="TMEM232"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15877">
        <property type="entry name" value="TMEM232"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="993" mass="109375" checksum="2DF4A8022E14E11E" modified="2023-02-22" version="1">MPITRVPIVHKFGIISQSQREELQERLLQQSYIQSVKTQRVPPTTRNPLELSESFVQQFNGATNLDEKEKLEGIARKMLNRTKRRAGILEGARGKNVDLPKAWTDLSMLAQCRGKIQEECLDLLIVSLSQAPLATVHIPSLFYLAETTLYWLRTDAMDQPFLRIGEIKLLKMGQGVFVRLYYHHMAGHLKGFSEYKNRLITYLAGVRECEEAYSPYPGAHLCLCFISEVGRLVVEDVLNEDPATLGVAPQKTTQAKPQSQGGVGTPSQPEPDSVSEFDNTSSRHPDQILEEDEEDLPSPTPSPKLPKSLPDTPLPSGMGNVVKPRSHTGQSSIHDLSPTLWHSLDVWRCVVHLSGGFKEAVRALSMCGSTLATEHWVDAMCALRIIAETAKSDIRVLKTLQNLARGVLPTTTPLPQSPTNQPEDVENEESKEEEADEPKVEEGELESIVSGLSQASLMSDFPEFGRSGARGKKLAPYSDFTKDGKHLSDLSGGSLLKSTGNTSTCVLMDTPKHAELLTSPSSFGQKASHGSTPSTTLNVSSARESLNSAGDIPLPSGLDDPSGSIEDSDLDPGDDSEVEANDVDVTRPQMSMPMEAGTKLRREVSFDIEPTERDGDLDLDFPKKSSLRDGSGRSDTRKSNSAKSVTIDPVPDTQYFSEASGSTSNKQAEPTSGVFKTKHPLEAQGLAGWPWEVGFTYAELMSHLCLHGSTAEIQRTALVGSKKKGYGPYMSKRPQGTSSRVPGTDEEQQCLPSAGLLDLAEYQGKIDGDETNDSAHWGWRIRYSAILGLVKVTRCTSTEKLQEGMRTVAWNALMRCHSMERDHKVLEAFRVGQVEAHIETQMQKALIVRSINSRLAAGLAAAYLPPLAPPVEVTKKSPRRKVELPKPKQPIRTGPNRLSLKQELLLATALDEPGVDFKTRTDLDLKRIVEDQWRKELQQQLEEDEKAKEKTLQEEQKTEEVRQKERSDAKASKLNKTSAASPPRPKTPSTVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3A4</accession>
    <name>A0A914A3A4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Guanylate cyclase</fullName>
            <ecNumber evidence="3 16">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 16"/>
    <dbReference type="RefSeq" id="XP_038058317.1">
        <property type="nucleotide sequence ID" value="XM_038202389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3A4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202389.1">
        <property type="protein sequence ID" value="XP_038058317.1"/>
        <property type="gene ID" value="LOC119729704"/>
    </dbReference>
    <dbReference type="GeneID" id="119729704"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016941">
        <property type="term" value="F:natriuretic peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688259" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="492"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="857"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115698" checksum="128D04877519BEAE" modified="2023-02-22" version="1">MGRGFQILICLFSGFVAFSNSTANFTVVKIAFMLSDGWHAALLSEIRILPAIELAMETVERRIGSGEYANFSIQTVMSSTGCAVPKRSAIGDAAHFFFYQDVVAFFGPACSGNIITVGDFAAVLNIPILSGSGSAVDLENKRRYTTLTNTVYRTGTMTEMVISIFHRFGWSSAVLIHGSHGFARSTDAMMEGFRGAELGLYVIYSENKEEDYEGMLREASVHSRIIFISADGNLVRKIMISAYHLGMVSGDYVFFSYHPFNNTKSFGRDSWNQGDEYDDILKVAYRALMTIRLFEPTTAEYVAFQHEINDRMQRYYNFTPEPGDEVNFFATSFHDALILYSLAINETLHEGGDIRDGMALREKMWNRTFQGISGEVGITANGDRVAVYSLWDMTDTENGIFEVVADYYGISQEIKFHKPIIWHGETGEVPRDTPICGFYNENPDCNPQENNTVLMVSTILAACLVLISVCVMFVVYRRMKLNSELMNMSWKIRYEDLVFTDTFRSVSSSIRSLSIGSADADGNNRRQIFTKVAQYEGRTVALKPLYAEKLELTMSLLKEFRKLRRMEHSNVVRFVGACIDGPDDLKNAIITEYCNKGSLQDILENDALKLDTDFKNSLLLDVGQGLHFLHHSELGVHGRLRSSNCVVDSRFVIKLADFGLLAYRDHTSADEGRAEMTKSLWKAPEYLRQPSKAPTKEGDIYAIGIIMQEVVTRGLPFDQERRANMDIKAILEKLTSPPPSSKPFRPQVVSGDCSPQMHAIMAKCWQEAPADRISSDALLSEMKKMCKGGSGGIMDNLLNRMEAYANNLEGLVEERTSAFLEEKKRAETLLYEVLPKSVADQLKVGSPVNPESYDSVTIFFSDIVGFTELSSRSNPMQVVNLLNDLYTCFDETIGNFDVYKVETIGDAYMVVSGLPIRNGNAHASHVANMALALLGSVGTFKVSHRPDWKLRLRAGIHSGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEPLKIHISDSTAGILREEDVFDIEDRGEIEIKGKGLQKTYWLMGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3L4</accession>
    <name>A0A914A3L4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058437.1">
        <property type="nucleotide sequence ID" value="XM_038202509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3L4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202509.1">
        <property type="protein sequence ID" value="XP_038058437.1"/>
        <property type="gene ID" value="LOC119729768"/>
    </dbReference>
    <dbReference type="GeneID" id="119729768"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037457136" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="124" mass="14106" checksum="D42949B5928A27C1" modified="2023-02-22" version="1">MEPNLHFGVLILLLISLRQAYHAYCEVKEKDEMPLSTFIHHFEPLNYDLGPLAVQQRNCIQQSSHDGVVINWEIAAFERSFHLQLAPYPNVITEGAQLNVVNELETSTTDLVSRLYKGIVIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7X7</accession>
    <name>A0A914A7X7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059531.1">
        <property type="nucleotide sequence ID" value="XM_038203603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7X7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203603.1">
        <property type="protein sequence ID" value="XP_038059531.1"/>
        <property type="gene ID" value="LOC119730617"/>
    </dbReference>
    <dbReference type="GeneID" id="119730617"/>
    <dbReference type="OMA" id="FANESPM"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="625"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="978" mass="108447" checksum="8354D8509D9E48E4" modified="2023-02-22" version="1">MNLNCPTRFPHPPRFITSVIFTYFLLITENLLFVHGASGDLPISTPGDPAWQDPELAGLWLGSDAAPYDPARASFNRKGDFYLGGLFDMHSERYGECQKINPRGVQWMYAMVYAIERINARQDLLPNITLGFQIKDTCANPNVAVTSSLDFITSSSNLGACDNNSMSFNAVDSLGRLVAVVGPATSNAAVSVASLFQLFKLPEISYSATSELLSETRYSFFTRVVPSDSYQAAALADIVSHFGWSVVATLYTDDLAYGLAGQERFLQHAAEKGICVAYENKISSSSTLEDLLEILEDLRGYPNVKVIVAFANESPMLKLLEVFAEQNVTGYTWIGTDAWTASPALTADPGIAKVTQGMLGLRYSTREVVGFLDYLQSLSPWEGTSYQDPFLLEYWEQALACHVFEIPREYRAYSETCVANETLTESDTLFAGKFVSTILDAVEVVAMALHAALKCDESQCEGKSDEVDREEILALMKNVNFTGASGYNIELTDGGNLGSGATYDVFNLKPSNSCASEMMVEKIGFWNQKEGFRIRDNISWHSKNSCYVGTIPSSFCSASCRPGQRRIPKGLSECCWECVDCLEGHYSDQEDALTCSNCSGEEIVNTDRTGCVQLPDLYFTPSSPFGIAVIILSVPGILLSVAIAAIFRHRRHTQVVVRACAGHSYAILSCAIFCFIFSWLPFLPSNNIVCAIKACLQLLPVTLLQGILLITAYITKKGRRYVQLRNKVFIGAGILALFCVFTAIWFAVDLPKLSRIPDPEAKIVYVDCQDGEVLALALSFLYSVFLDAVGLCMAYRTRAKEENFREGKFVFFTFIVHIMLWVATLGVYLAIGGGKHFQSFILAEGVTFTGYVPLFMLFVPKLYLMKTKPYANEKMDAKAKRKVRGKRIAKVKSRKARLSPEVLSSRRALLDNCNRALESIRGERTQSVRFVKICSERLEEMKARHRRRVDAKKSQLGDCLKRKVHLIISSPTLPSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8K4</accession>
    <name>A0A914A8K4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060192.1">
        <property type="nucleotide sequence ID" value="XM_038204264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8K4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204264.1">
        <property type="protein sequence ID" value="XP_038060192.1"/>
        <property type="gene ID" value="LOC119731192"/>
    </dbReference>
    <dbReference type="GeneID" id="119731192"/>
    <dbReference type="OMA" id="WRAVIYG"/>
    <dbReference type="OrthoDB" id="6374566at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="529" mass="59356" checksum="7A6CAF7FB2417464" modified="2023-02-22" version="1">MVPCKHRFGSSCSQAGAKRHARIPLEPISKAERGILTHGQPRISVLLQTQCGFRAARSTVDMIFTLRQLQEKCREQRRPLYLAFVDLTKAFDLVSRDGLFKLLAKIGCPPKLLSIVTSFHNNMQGSVCCDGETSEAFPIRSGVKQGCVLAPTLFGIFFSLLLSFAFGSSPEGVYLHSRADGKLFNLARLRSKTKVTSVLLREMLFADDAALASHTETGLQQLVDRLSYACKEFALTISIKKTHVMGQEVETPPSISIDNKTLDCVGTFTYLGSTVASNLSLDAELSTRLARAATVMARLAKRVWSNKNLTVCTKLQVYQACVISTLLYSSEAWTTYTRQEKRLNSFHLRCLRRILGIKWQDKVPNTEVLERAHSTSMFAMLSQRRLRWLGHVHRMDSGRLPRAILYGELSSGSRPIGHPNLRFKDDCKRDMRQAGIDPNSWEEAAQDRSAWRQTVAAGIHRAEERRTSLLQEKRQRRKLRVAAPTPESVPSPFVCANCGRDCHARIGLLSHSRRCNKDDNPPGAVHRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACJ2</accession>
    <name>A0A914ACJ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061064.1">
        <property type="nucleotide sequence ID" value="XM_038205136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACJ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205136.1">
        <property type="protein sequence ID" value="XP_038061064.1"/>
        <property type="gene ID" value="LOC119731850"/>
    </dbReference>
    <dbReference type="GeneID" id="119731850"/>
    <dbReference type="OMA" id="KYTICAV"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="140" mass="15716" checksum="D048896C37957CAC" modified="2023-02-22" version="1">MEDWTIPDDRITASSSSGDKLAKKGRLNNNNAWQAASETNAWIEVDLGESTVVSGVITQGAFGWYVKHYKVAYKKQPSSDYEYVMDGNGDNKVFIGNFDVHTPVSNMFDESVSATVVRIEPNKWHHHVAMRLEYSGCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADL7</accession>
    <name>A0A914ADL7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061581.1">
        <property type="nucleotide sequence ID" value="XM_038205653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205653.1">
        <property type="protein sequence ID" value="XP_038061581.1"/>
        <property type="gene ID" value="LOC119732219"/>
    </dbReference>
    <dbReference type="GeneID" id="119732219"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037411612" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="152" mass="16916" checksum="A2D39F142B524645" modified="2023-02-22" version="1">MFKLLVTVFLLSLAVTPSVSWDSRCPPITDFMRLSISSLWREEVEQGGAFWACAACHRMVCTLEQIKTAYYEEGYGTETLSWYNPDPNTLGMSGLGLADVNACSVLTSGPCLFEVDGVRAVRVFPGTQSNHGHALCCQRPDDESDMRSYRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEX9</accession>
    <name>A0A914AEX9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061919.1">
        <property type="nucleotide sequence ID" value="XM_038205991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205991.1">
        <property type="protein sequence ID" value="XP_038061919.1"/>
        <property type="gene ID" value="LOC119732466"/>
    </dbReference>
    <dbReference type="GeneID" id="119732466"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037065437" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="158" mass="17470" checksum="84FE5FA3E5208340" modified="2023-02-22" version="1">MYKVMMTVFLLTVLAVTPSVSWDNNCLSLRDHYLMKSIGRITKEDMQLGMAAVACESCYRQVCTLEQLKEAYYFKSKDGSFPGEPGWYNPRPGERASGNLGVAKVGPCYDYDDGHECAFDIEGVRAVRIYASGSINVGHALCCRRTTPLAGGRGSNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF34</accession>
    <name>A0A914AF34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062357.1">
        <property type="nucleotide sequence ID" value="XM_038206429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206429.1">
        <property type="protein sequence ID" value="XP_038062357.1"/>
        <property type="gene ID" value="LOC119732826"/>
    </dbReference>
    <dbReference type="GeneID" id="119732826"/>
    <dbReference type="OMA" id="CKSERAN"/>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037202995" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="509" mass="54112" checksum="B22C25770DE46C68" modified="2023-02-22" version="1">MDRLWTSVTLGVFLACLPYTIVDAVGPSDTAALRGGAATLTCSNPAYTSPSSGAAFWEEGGTPFGTQQNGIYTAPEFAKYTNFDIVSTEYPQMDLTVSNAQVEDEGTYTCTLQSDQGSATLTVEIEGNEPTITLNSDPSVTPIRLIAGVESVLRCTASGFRPAVNLEWYKDDVKITAGITEDPATSNGDTFTTVGTLTFTPTIPDDGDRLECRTTGQVVATAKTGALTLSVQFVPVVTVGYSGGQITCSSEANPLATTHQIIRNGTDVLKEFTNSPGSVEFTPKYCAVISCNATNTIGTGTDTFADQICPVIPDETTTEMPSTGYVEPTTPAPPKPSEPTPKPTVGLDAGIIAAIAIGCLIVVALVIGGIVYCYTQKKFCFDSNKTSNGGSSPKKQPSVVNADMIRNQPEVRQSVHNYDDEPKKPRVPRSNSGKPAPEKEALKQSAPPTDNDHQGYPMDSYDGDPQEGRGQAGVNYADLQFQNRDRPTNGHGKIHQSDEEPTQYASILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFU8</accession>
    <name>A0A914AFU8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062607.1">
        <property type="nucleotide sequence ID" value="XM_038206679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206679.1">
        <property type="protein sequence ID" value="XP_038062607.1"/>
        <property type="gene ID" value="LOC119733099"/>
    </dbReference>
    <dbReference type="GeneID" id="119733099"/>
    <dbReference type="OMA" id="HARVITQ"/>
    <dbReference type="OrthoDB" id="10050996at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF5">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="20376" checksum="0A0F03EFF6B4B624" modified="2023-02-22" version="1">MYRQVEVISDLISTPRRVLESLSCDSLPLARHQDLIREAASVGKTFHEIFMKFADVHFAINHARVITQDDLRRVDSCIVDFMATYRMKFPTHSITPKMHLLEAHAVEQLERFGVGFGLLNEQGGELVHTEFNRTGRAVHGMKDDLQRLLTIMRRHHTSTVPEVQAQYIPAVKRKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJW1</accession>
    <name>A0A914AJW1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063841.1">
        <property type="nucleotide sequence ID" value="XM_038207913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207913.1">
        <property type="protein sequence ID" value="XP_038063841.1"/>
        <property type="gene ID" value="LOC119734416"/>
    </dbReference>
    <dbReference type="GeneID" id="119734416"/>
    <dbReference type="OMA" id="PHICESD"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF1">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="624" mass="71421" checksum="B0CF90424E3264AB" modified="2023-02-22" version="1">MDVKPGNCWRCMKPLPESLVTCGRCPQAKYCSDQCQEQDRVRHGAVECQMFGPKSCSYCKKTGEMKQCAGCNNAWYCNGTCQRKSWAAHKEVCQDIQAMIADLSLELTNKYTDLAKGDVTHTRETFLDPPYYFGNTMACDFLQLGQNEWADGIRADETMRDFHILSAGCGDLRHTVLTAASLPAEYQGKVHIVLNDLDPYVMARNVLFLYMLILHKDREGIAASLATLWYSLHISKCDYNLTKTSLRKLIQADARSIQEAMKGCVSISDEDLAKLRYVWKGWYSLECERIKSSSVNLTKQRQAVFAENFFFSHELQLYYERLSPKEAKNLKTWFQRGLFLAQDSSVRSLPFDNPTLTARRQQIVGGYMEATDDFVYCIHRNLTPFTALDSLQVQGSAGETTSTPTVMYHKYVEKQLQKTSTLLAQDRLHIHMLVSSCLEIPRHHQAQKMAKFDRIFTSNLADFVGCRKLLQTLRPLMNPNNKNATLVTETMNWILYMPEANVWDERSGRDINDSTKTTMQLCKDDTGKALSSPMAISNQIEYFNNTHWFCAYLRANMMAGGFHIPELDHIPNLKEAMKCEGLQMHDFREELNKLVPFKFRVNARSLTSPTGAERALEWYLPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK62</accession>
    <name>A0A914AK62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063956.1">
        <property type="nucleotide sequence ID" value="XM_038208028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208028.1">
        <property type="protein sequence ID" value="XP_038063956.1"/>
        <property type="gene ID" value="LOC119734494"/>
    </dbReference>
    <dbReference type="GeneID" id="119734494"/>
    <dbReference type="CTD" id="56970"/>
    <dbReference type="OMA" id="LCTRSMR"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCA7" evidence="12">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="41588" checksum="A34B4B2B7B04843C" modified="2023-02-22" version="1">MEDFLLHHLHEASPSPEDQGGLEEDIFADVLQELTLGFCFEIHRSCKMGQLFLDETDEPSLKFYEIVNEPGRDVFGKPPLKKQIDCICPHCNRNLSASRFAPHLEKCMGMGRNSSRLASKRIANSGMGKMDSDNEDDDRDLDWSFAFDKKVTKKSKKDKVSNNSPRRSKPKIGTKMGDFPCGGSLPSESMAGSMTSYASKSFSSAPYEGLSLEERKRLLMSTCGVISEHTHKMCTKSLRCPQHTDEQRRIIRRYLLRIDPEGRLRMRPDGSLEADDIQVDIDGYEDGDGQALRETLNRIQQWEGNTSSANPSPADSTSTTNSQEKRRKKGSAKLTQRKKSKVKPPALHVVSSAGSTSSFLSSCADTQFHILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL34</accession>
    <name>A0A914AL34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FOXJ1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064288.1">
        <property type="nucleotide sequence ID" value="XM_038208360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208360.1">
        <property type="protein sequence ID" value="XP_038064288.1"/>
        <property type="gene ID" value="LOC119734799"/>
    </dbReference>
    <dbReference type="GeneID" id="119734799"/>
    <dbReference type="CTD" id="2302"/>
    <dbReference type="OMA" id="HADMIVN"/>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20023">
        <property type="entry name" value="FH_FOXJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047512">
        <property type="entry name" value="FH_FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047513">
        <property type="entry name" value="FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="11">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="9">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="457" mass="51278" checksum="3C656E2ACDB11988" modified="2023-02-22" version="1">MATKVITVPIMSTNDAATRFRQNWLSRNPPSPQLHSDTSSNGSTECNLDDSLTSLNWLQNLRIMRIQQPTPPSSPSPLGSACQRLNTTITIQAKGPNGGIPRLKTTQEEAKAISRIGHHHPMTTTTSIDQIDYKTNQYVKPPYSYATLIWMAMKASKKNKITLSAIYKWITENFKYYQTADPSWQNSIRHNLSLNKCFMKVPRRKDEPGKGGFWQIDPAHADLLENGIFKKRRCSSTRDFFPENIKRIKIEPIDDGYECHDKHHSRKQSAPKRKAPDHDQPKFRPFQLNSLGSADLSDSDDNLPSAVLRGDIGWNSIFQSEIDVEGIKVKTEDILDEAEQDRCSSPFLQISPPPSNEAPQDFGDFLDLSISGVHIPRPAWFDEHLHDLDFTSEEAEMLLSGIDLPPSPVSSINDQQSHPWAEAGGPASFDVEDLLGLRSVSGDDMPWDLSLQPVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALD9</accession>
    <name>A0A914ALD9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038064249.1">
        <property type="nucleotide sequence ID" value="XM_038208321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALD9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208321.1">
        <property type="protein sequence ID" value="XP_038064249.1"/>
        <property type="gene ID" value="LOC119734773"/>
    </dbReference>
    <dbReference type="GeneID" id="119734773"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF8">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="410" mass="46309" checksum="235F944DFDA11BF3" modified="2023-02-22" version="1">MPSMRSKIARSRRIKAALAGGVLLYGVILLVSTSTKQEQHMAYPWAAQGDGFRQAHRQEHLRHTMEIEANSQSPAGRRGNASRLLIGNHTNSLSPAGSRGNQSQQLKGNHTVVELNKITEEPLKCTRTLKSLTKYSKWFQGRYQPKVKLFLDKNDINNYKSYLTRGLPYGFKGQNHTEFDLVLKNPNFTNPSIHGAHRKAGCIRCAVVGSGGILNGSGAGAEIDGHDYVFRVNRALSRGRFATDVGRRTTFYTFFPESQGIGNVEDKSMIAFYAMFKAYDVAYAKKLIQGDKSPRYNITATSRGMKRPGLEASKLKIIHPAFFNYVSQVYLMRKARPTTGSIVVIMSLHICDEVTIYGFGYDPRFTMHYYDSKFIKHTQKSTASHNVDNERKLWMKLHDEGVIRLFKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALG4</accession>
    <name>A0A914ALG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein 45</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064396.1">
        <property type="nucleotide sequence ID" value="XM_038208468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064397.1">
        <property type="nucleotide sequence ID" value="XM_038208469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208468.1">
        <property type="protein sequence ID" value="XP_038064396.1"/>
        <property type="gene ID" value="LOC119734867"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208469.1">
        <property type="protein sequence ID" value="XP_038064397.1"/>
        <property type="gene ID" value="LOC119734867"/>
    </dbReference>
    <dbReference type="GeneID" id="119734867"/>
    <dbReference type="OMA" id="EVDHMTR"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="79251" checksum="4A26B6D2F879DEE1" modified="2023-02-22" version="1">MEDFRTSYLRLCKENRLEPQQSVLSHLSHGKHTETSGGRSPRGTPSKMGPGNHGVVLDLSTTSLTVQTCSVLGAALAKDCLYGELRLSDCMIGDEGFKLLAHSLCSNAAVRNLDLKGNNLRGPSAEALGKLLGQNHTLRRLCLEWNSLGLDSDRFALLAEGLAANNSLEVLDLRNNQISHDGVSELCKALQRNCVLSSLDLRWNNIGIVGGRSVLAMLQYNKTLTELELAGNNITQDIMKAIDVARQHNLDRASLTNEHQSRQSIMTREIKQLRTQKKQQASDLLHRIDQQNELQSRTHRDTAHKIHQLQEALAERKCAFNALNAKLSKTEAELLLAEQRSRDLSDILEVSRKENSSLVAMHQKEMQTQLGEKASSESKLLHDIASLKDRNLHLETKADELDKRCQHQQDQIYELKEELATSHAQVKLQATQAEERLQNEKQRLRDQQRDLERRHASEMQHQRESAEESERAYRDRIVKLEEHRRSLEEEMSKLKNQQLTERLALEEQILSTRQRVKEEEHQRMKHLEDKIRLLSNAKDDIQQHYSQQMQTIAELQAKNNNAGLEVESLKRRLEELNQELAGKNNELQAEVNKVKLSSSKQLSRMEAQIQDSESLRERCSTLELQLAEQTRRHRTELMDRDNETDSLRERMRSQDMEYSRIQEEETQRAGMLQAAISGYLTSTRTPMSTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALU6</accession>
    <name>A0A914ALU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064404.1">
        <property type="nucleotide sequence ID" value="XM_038208476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208476.1">
        <property type="protein sequence ID" value="XP_038064404.1"/>
        <property type="gene ID" value="LOC119734870"/>
    </dbReference>
    <dbReference type="GeneID" id="119734870"/>
    <dbReference type="OMA" id="PIRTYRI"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="38870" checksum="9753F1BA3F3F0FE0" modified="2023-02-22" version="1">MDDSLLATIHAQFLSMMSVRNFVWMVSDQFVVDVLQCVESQIQILKVTVKCDICNKYPPSLSYQQSFLKSLIQKCEASDSELADEIYETYTALLSTPQPEMQDCCYRTYIVSDESCTVTLKESVSMISLGTTGLNTWPAASYLTEWAMENQDIFSGRSVLELGSGMGLTGLAICKVCQPACYVFSDCHDSVLRGLRDNIDINVPDWDSREEPKKFPSEGLGASEEGKAKETVIAVECLDWEAVQDKAVQSWNSGVILAADVVYDTRIIEPLVHLLHMLLRCQGDGQGRPVAIVASTVRNKETYAAFREAVERCNILVEKIHGPKHKTLHYDRSCPIELLHLHVSTTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMN3</accession>
    <name>A0A914AMN3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064997.1">
        <property type="nucleotide sequence ID" value="XM_038209069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209069.1">
        <property type="protein sequence ID" value="XP_038064997.1"/>
        <property type="gene ID" value="LOC119735371"/>
    </dbReference>
    <dbReference type="GeneID" id="119735371"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="15">
        <location>
            <begin position="190"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="286"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="526"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="94046" checksum="95EBEB46B88F924B" modified="2023-02-22" version="1">MARYISLDIDTSMPGVDPREAYLQLAEVTVENVTSGECAALPVYGKNTSQSSTWDAHPSYKAIDGRKYTYTHTDANDPHPWWLLKLGSKHCLGRINVTLRMNGWGFRFIGAIARAGLSPNFNENLPCGSPATSNQSKKGAEIPFLCEPPRLARYVSLDINTSIPGVDAARAFLQLAEVAVEEYTSGECAAPGYLGCFGDAEYRSLSVGPAATEYEQSVEWCFRNCLEPTEYKYAGMEYKYECWCGNDNYDKHGKEPDSDCKYFCPGNSNQICGGKWRISVYTVSQGVCSNDIGPPTNGDHTITNPRSLSYNLINYKFFGTRVDFSCDPGYTLHGASSIECIETGYNNVTWSDSVPTCEDNVCINPNPCQNGGTCIPQSTGDFYNCSCPAGFIGGDCQNSADDPCMTNPCQNGEQCMPQGNSYDCTCQNGATGNNCQNANANTTTINVVVVIVVVVVVLIVLLVIVVVCFVKRSRRNRRASRLSAVDRGRGQELIQKKLSNVYLIDTLQASTSELNGPAKEFPRDKLHILGQLGSGSFAVVYKAEAEGIIRRGTNTTVAVKMLKECATPNDQSDFKKELRLYSMLDRHPNVLSMLGYCTDKDPMYIILEYVPHGDLQTYLRHIRTGTEPFYLKKEEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHRDLATRNILLGEGLICKVSDFGLARDVAEKSQYEMQSQGRVPVRWMAPESLLTNMYTIKSDVWSFGVLLWELVTLGSHPYPGMSSQKVIDEIKQGYRLPKPEHCSDDIYQIMMDCWQEKPEDRPDFAGLHTTIDDILADAAGYLEMGNLNPDDYVYLKSGQSSTSITHSPTRSPTGSIESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMU2</accession>
    <name>A0A914AMU2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065350.1">
        <property type="nucleotide sequence ID" value="XM_038209422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209422.1">
        <property type="protein sequence ID" value="XP_038065350.1"/>
        <property type="gene ID" value="LOC119735635"/>
    </dbReference>
    <dbReference type="GeneID" id="119735635"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="313" mass="36772" checksum="9B4A7B90E4BCC057" modified="2023-02-22" version="1">MDKYVTIEEYRELRKNEFTDKYPHTLGEYEGVQLNFSVCEMMDELRSFEVRADDCWIVTYPKAGTTWVQEIVLCAKHDGNLQEVNKTHTKFQVPFLEQSMPQEIRRLKNLPPTHRIAAEIPSPRVIKSHLPGQLLPPQIWTKKAKIVYVIRNPKDLMVSYFYFENLLNLKGAGLPFEEYLEYRNSNKASYGSWWDHYLYFWKRRHQPNVLLLRFEDLKRDLRGNVETISRFLGKALSAKTLDDITEHCSFDNMKSNPMINPDYLLSTDERPGRSFMRKGKSGSWKTHFTVAQNEAMDALIKEKLHGTGLTFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN82</accession>
    <name>A0A914AN82_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064889.1">
        <property type="nucleotide sequence ID" value="XM_038208961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN82"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208961.1">
        <property type="protein sequence ID" value="XP_038064889.1"/>
        <property type="gene ID" value="LOC119735258"/>
    </dbReference>
    <dbReference type="GeneID" id="119735258"/>
    <dbReference type="OMA" id="RECECTY"/>
    <dbReference type="OrthoDB" id="10023676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="50751" checksum="072F88A57C0A26C5" modified="2023-02-22" version="1">MTEFKCSLCVFSSKSYERYVCHVVRFHKSDPNFIVFCSVDNCSYSTKSWGAFKCHMSRKHRDPHNQNLQVSDDESDTGMDSDNELDHAGGVAVDVRHRNAAFALGLECGCNMPSSSVNEVVQMVSSLIDDHLAHFKTQICSEFRQNGIPENIINTVNSIPISNSLGDFSTQKNRNSYYSKELCYVAPQRVILGDKYVSVKGELVKRDVVGYAVPFIDSLKNLLHMPEVWKFVNHPHTSQSEYMFDICDGAFFKMDPVFERNPRALQVILNTDDIEIVNPIGSHTKKHKLSMFYYTLGNIPPECRSRLQTIQLLAVAKTKDLRESGPGVLLKDFISHMRTLSTGGLDMQVNGNNVHLEGQIVVVACDTPAAQWFGGFKEGVSFAHRGCRNCKATGHEMKRTFVERDFVLRNEEEHRRRCIMLDDNLSKPARNYWSRQWGINNQKQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AND7</accession>
    <name>A0A914AND7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064949.1">
        <property type="nucleotide sequence ID" value="XM_038209021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AND7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209021.1">
        <property type="protein sequence ID" value="XP_038064949.1"/>
        <property type="gene ID" value="LOC119735323"/>
    </dbReference>
    <dbReference type="GeneID" id="119735323"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="221"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="314"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="507"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="89717" checksum="1C955AE0163AE353" modified="2023-02-22" version="1">MTVYEGSQATLICNYTGSSIQSLEWMKDDDGAIQSPTQIAEIIYHIGNEPIYHNGYNSSTYTASIDWHTNTFNLLIHSVDVAADGGTFWCFARYWVGTLIISSIDLTVIVLPKTIALSDSSTSYPSADGTAYLLKGMDHRFTCEVPDINPGASFTWSLGDATITPYNTVNVTGADKLTTSTSMATFSPTWSHHGKTLRCQASNDEEYEGISVNIRLYVIGPTETPVITGSTSMTENEATLLTCTADMGYPDDWTLVWSNGGSPGPTTSLSESGDRYSFTSTLDYTPRRQDNGNIITCTANRAPWIPGPVGSLGPIDVKYEVNITNKAMNEVRVKDGENAVLICIAVGNPQPLMEWYCTNNTMITSDVDEGKFPVTHETSGGDGIFEFKVTSKLTVKAVDSQVDYGVYTCISSNGIGREDSLNITLTEIMTNVPPTTTVPDDKTVVIIGIIIGFVVLTVIALGVYVTRRSRKASGELDCISQPANKKPGTVDYANVPTAHKAFPRDQLKIIKELGHGAFGQVLLAEASGMTQGSKVTLVAVKTLKDGAGNSEKADLMRELDLMKKLPDHCNVVRLLGFCVEEDPPYIIVEYQSRGNLKDLLKDSRSKGRRVYGNLHGISKSLTSKDLMKFAKDVADGMAFISSQRCIHRDLAARNVLVAEDMTCKVADFGLARDVMNIRVYERRSQGPLPMRWMAFESILDDVYTTESDVWSYGVLLWEIVTLGARPYPAMTAKIMVNELQSGYRMPKPLHCQEELYVMMLRCWYEDPDSRPTFKMISKELDKLITKEKEYISLDDFEESIYEVALKDDAGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP57</accession>
    <name>A0A914AP57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-complex protein 11-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065266.1">
        <property type="nucleotide sequence ID" value="XM_038209338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209338.1">
        <property type="protein sequence ID" value="XP_038065266.1"/>
        <property type="gene ID" value="LOC119735577"/>
    </dbReference>
    <dbReference type="GeneID" id="119735577"/>
    <dbReference type="OMA" id="CRDEDIN"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57149" checksum="862971BA0F4C42A8" modified="2023-02-22" version="1">MPLEDKDKDTPKSTGDDCGDSPGASNASDQEPALDSSGEGEIFRKRQRVNSPRKNEPMASPHKHATFEELLKTAGLVSNMALAHEIVVDGNFRLKPQDLPDNSIEKQVRDIMHKAFWDSLKEQLEGDPPSYDHAIILLGEVKEFLGSLLLPQQERLRTQIDEVIDLPLIQQQAEHDALDVYHYGNFIISTMAMLCAPVRDEEIAKLKDLVDVVQLFREIFRILELMKLDMANYTLQSLRPHLKQQSVDYERGKFQEFLKTQQDGLELTRKWLEEAADDLRSREPQQPMEGATSSTSSSPSLTPVIILNHGYMRLLDWQDARLFPETIVMDQARLQEMADRLRKSVLIATVLLVTYTNVGPIITSIQGFPSNLKHHIDTILEGVNDHSAIMPNVADQVCTDVDKCLKERGIAEMDAMKTDALKSQVIAAGDREHSVHKLLDSRARSFIKMLMSGPINFDPSTRIPPGLTTIQPQLLEVAGQFVRVIGHNRTVYGPFYSEILGKMLNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQK3</accession>
    <name>A0A914AQK3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066042.1">
        <property type="nucleotide sequence ID" value="XM_038210114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210114.1">
        <property type="protein sequence ID" value="XP_038066042.1"/>
        <property type="gene ID" value="LOC119736103"/>
    </dbReference>
    <dbReference type="GeneID" id="119736103"/>
    <dbReference type="OrthoDB" id="5980679at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="378" mass="41556" checksum="3F31B4350DD04A9B" modified="2023-02-22" version="1">MVSPHQLGKCPPGTAVLDMPYSLTLQTCDHHGERLTSGGYNIRADITTSSSEEPKRQGDVQDNEDGSYTVTVTPRAPEPLIVNIKICGYPLKSGMPLVIPVQDSLPFVDPPDGYKNPSGMAVDINRKAVYITDIIERVGCYVRQLKTDGSFVSTKMIKKLSLQLNNKSQLDLAVAQDGRLFALFPHSKGVVTCNYNGKSVEWWPCAEDNHQPVSITLSRADHVIVGDGDSHKLFIHQRKGEIVGRIELPKGALSAGTQNVCVDSTHDDILVVTHSEPYKILRYTINGNLVCTINLTAKTTQQAMAAESTPEGALVVSLRGRILVLAFTPDRKDIAVVKMFKTDHTYTRLAVIGDECFVAFDPAAKHLAKYSYHHRPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR55</accession>
    <name>A0A914AR55_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the requiem/DPF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065919.1">
        <property type="nucleotide sequence ID" value="XM_038209991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR55"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209991.1">
        <property type="protein sequence ID" value="XP_038065919.1"/>
        <property type="gene ID" value="LOC119736005"/>
    </dbReference>
    <dbReference type="GeneID" id="119736005"/>
    <dbReference type="OMA" id="TEMKYIL"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="44279" checksum="5BA49535DE60C6D3" modified="2023-02-22" version="1">MSGLARKNGDYEQFYREATENAASFNTRLVAERKMRLPFLDSQTGVAQNNCFLWMQKRHRFPGRHEGQLYTYPSRRWRKKRKPHHAPLADSSNLYDPVPQGEADGIEVPETVQGVLSETDQHPEASSMSLADREQEELFREMEAVDDIPDAGEIERNHSDESDEDFEVSARKRRGRKGRGGGRKKAAPVDTEMPTLQAEDKEKPFGCKVCGKRYKNRPGLSYHMSHYHQDVEAGSDEQSQPSPLEPTEPPKKKMIKGIAEPNNYCDFCLGDTYRNKEGTQEELVSCADCGRSGHPSCLQFTENITAKVKSYRWQCIECKSCGLCGTSDNDDQLLFCDDCDRGYHMYCLKPPMSAPPEGSWICDLCVTPPPAPQPPQTEASQPPNPEETSMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS31</accession>
    <name>A0A914AS31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066582.1">
        <property type="nucleotide sequence ID" value="XM_038210654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210654.1">
        <property type="protein sequence ID" value="XP_038066582.1"/>
        <property type="gene ID" value="LOC119736606"/>
    </dbReference>
    <dbReference type="GeneID" id="119736606"/>
    <dbReference type="OMA" id="RCTMARR"/>
    <dbReference type="OrthoDB" id="10148914at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="166"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="637" mass="70783" checksum="CFF91E33F9C0BA64" modified="2023-02-22" version="1">MNSWKMECLCIFSLRNLPVSVSSIISHCLIVTLLVCSPRIINGADRFKDGVLVTDSRFYLQQGRSQRISCTSLNDTSDVVVVFWYKLPQVPDGDFEPDLLVRFTLDLHGGNYSAGPRYQLAPDMSLIIKSVVGEDAGRYQCQKVSSTQADNRENEVEVVVLDEEFPAARGVVREGRNITIKRNQQEFEISCPIEEVSNLRQPTVYWSTETSGLDEPTEIVAQMFSDEETYTTNDYRFASSNNLILPAVNSENSVGLWCHVSSSLDHLFLQSARVSVNIQDESYVGLIVGVLVAVTVVLIILVFLVCWKRDRVKRTFFKEDVHLQGPSISSGNQDEWTLETYLGPKGNNFGGKFSSLKSVASFNKSFLAVLDDNGLHTFSPDLTRLDHVTKLKASPENYVTMVTHTDGLLLLLGAKNGDVTSVSFKPFSEKLFCSLSEEKTDPDEKNEDSDSIKEPKGTSSESAALTMVSHELTDLAVDANGDVYAGDNSNHTVTIFTPGQKGCSKRSFELDFPPKILAGGSEGEIFAHNGDHGSPIKRIKVNDKNVETVFLDVKNSPVNPVNVLVDNSHVFIVSDTKVNGQMEILQYDNKGNFLRPFVKPWLGIQGMCMFASGERLALFDHSIVRIYRKQLAKNRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT14</accession>
    <name>A0A914AT14_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066491.1">
        <property type="nucleotide sequence ID" value="XM_038210563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT14"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210563.1">
        <property type="protein sequence ID" value="XP_038066491.1"/>
        <property type="gene ID" value="LOC119736546"/>
    </dbReference>
    <dbReference type="GeneID" id="119736546"/>
    <dbReference type="CTD" id="9419"/>
    <dbReference type="OMA" id="MPCDKCE"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="100" mass="11235" checksum="BC0266CDE3D5600E" modified="2023-02-22" version="1">MVCEKCEKKLGKVITPDPWKSGARNTTESGGRKVGENKLLTGKKARYNPYTRQFNKCRICKQSVHQVGSHYCQGCAYKIGICAMCGKKILDTKKYKQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT22</accession>
    <name>A0A914AT22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKA complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Spindle and kinetochore-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067205.1">
        <property type="nucleotide sequence ID" value="XM_038211277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211277.1">
        <property type="protein sequence ID" value="XP_038067205.1"/>
        <property type="gene ID" value="LOC119737154"/>
    </dbReference>
    <dbReference type="GeneID" id="119737154"/>
    <dbReference type="OMA" id="VEEDMHE"/>
    <dbReference type="OrthoDB" id="5962at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1890:FF:000002">
        <property type="entry name" value="Spindle and kinetochore-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1890">
        <property type="entry name" value="Ska1 microtubule binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009829">
        <property type="entry name" value="SKA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042031">
        <property type="entry name" value="SKA1_MBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573:SF1">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07160">
        <property type="entry name" value="SKA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="31462" checksum="3CC4C30E01D2E9C2" modified="2023-02-22" version="1">MDASNLDELKETFEGKIAGLTRCIDLSSAVLTPDGLDENCRKQLGVIHMELCMVESLVGQMRELVHSEKQKLQRAEALKSQMEEQAKHIRYMESHLPDRLPGRELKTSTSSKVKGRTPLGTVQDKSNHSNQGTRQQKSSSKDKETTEDSKKRKPSTPTMEFVTVEEFEGVPKYMKGRLNYDAINAAVEIINTAVSARYSLLHKPRHALGENAMKKVRRLKEQENKDTKGVFFFTDEDFKANSNGRCSTTSRSIFTILRHCGRLREIRSAGLTRYALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATF5</accession>
    <name>A0A914ATF5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066764.1">
        <property type="nucleotide sequence ID" value="XM_038210836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210836.1">
        <property type="protein sequence ID" value="XP_038066764.1"/>
        <property type="gene ID" value="LOC119736827"/>
    </dbReference>
    <dbReference type="GeneID" id="119736827"/>
    <dbReference type="OMA" id="SATACTH"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218015" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="669"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="951"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="107290" checksum="4A86BD1156A61ED0" modified="2023-02-22" version="1">MAAGLQQLMSLLIVASLCCENAQGTTGIPSPTDPDADTTLPNTTDGPTTPAEREIPYACPKARSSWHTCRISGCREPPWQRFYCHCDPLCVTYGDCCPDVEEYSVVGTDEDGVTTAGDAATYGDRSSGSENIEKDLRCIQTNEFDPEVSRPRYGYRLVAACPPDWTGAATVTELCQETVGMDGLAAVPVEGSDGRHYRNVYCAMCHGLPHTNVTFWTVSYQRKFPFRGLLNTSQVLQVAKGQGMTRFFFNKYFIPPQYEDADYLAASSLRTCSILDAISCPISDHRTLELCNRYYAPIAWNGTTFRNFACVQCDDAPIFPSGILWALCDSSKSSGFGGSMATLLVFSDHTDIGGDLARDGSVSSATACTHRQIYDPFSSSCLDLSCPDGFALEDGGVRCARIRETENGSTSLKVDVEVALTVTVSLDNDADAQSTNRLNELGEEVAQQTTKDYRYIVSGCEFENEMTENNINRENEFCNDFSVQWSCKRGVATLDATPACLSGSVFKCNVNVSFDSLALSDDHFIAQNERLSGQCFASRIGNHTIRPDYLAVSTPCETLSNDTEEESNVNHVFTSKVAYVRDNDSGHFVVSQNDSCADAFVNCPLLTFSKEDYVITGALNDSIRLTAHDRVLRSGEFEIKSKGDVEVCNFLQPGAPSTTPTFMNWGPAHFILTVTGSSLSLIGLVVTIATYVVFPSLRRNAAGWALMSLVAALFLAQLTMLIGLDRTDVPTLCVTFAIGSHFFWLAAFFWMNILAVDIYRTFGIGTSLSNPNERSFLRYALYGWGAPTLIVATVAILSFCDCVEADVHYGSAHACWVGNGTANLLSFGVPIVVILCSNAVLFSLTMAGVKKTRMASKRMNITQGQSGSAAKKPNNDLVLCLKLTAIMGFTWVFGFVASFSGVELFWYPYIALNSLQGAFVCLAFVCNRRVLAMWRAWLKSRRVRYLADQSDTSGSRRGQTSLKESVSDQSHVESGTKTTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV35</accession>
    <name>A0A914AV35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067344.1">
        <property type="nucleotide sequence ID" value="XM_038211416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV35"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211416.1">
        <property type="protein sequence ID" value="XP_038067344.1"/>
        <property type="gene ID" value="LOC119737226"/>
    </dbReference>
    <dbReference type="GeneID" id="119737226"/>
    <dbReference type="CTD" id="64781"/>
    <dbReference type="OMA" id="HHRWKWA"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057465">
        <property type="entry name" value="CERK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25382">
        <property type="entry name" value="PH_CERK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="129"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="568" mass="62612" checksum="616433F8FFBBD55A" modified="2023-02-22" version="1">MAEDVVLFSVLKLAGKPLDVTLSSRTISWVASASSTAETREVHHYHFVKMSKVITAVVDSENAGDKNPGSAKPRKLDNHDDLTFTVHCIRRNSQGKWRVRELKFECSDQETCRRWVAHIKERIVKQGNVRPQNLLVFINPYGGKKEAGSIYDTHTAPLFSLAGIKTTVIYTEAKNHARDVMLKRDLTEFDGVVCVGGDGTFAEVVNGLLVRTQQEGGVDYNDPDTTPQCPLMRIGVIPAGSTDVIVCDTTGVTDPVTSTLQIVLGCSLGLDICSVHSGHQLLRYTVSFMGYGFLGDVLKDSESHRWMGPHRYDFSGFKKYFGNKAYAGEVTFLTSGDEDHHPQDKTKCRVGCAVCLRRSDSQTSDVFECLDSSTGGPDLQDDNKSLVKENNGSWKKVTGSFCAVNAALVSGCNRLAPNGIAPSSHLGNGCLDLLLVHKCSRFNFLRHLIRLGNSGNHFNFDFVEVHRVKEFTFKSLTSQDLKSAGNPAGESTSNTSLVKQRQSRYQATGDSNTSTWNLDGEVGDIPDINVHVHCQLIKIFAYGREDVKSLNASCCMSRNRTKNKSAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXX1</accession>
    <name>A0A914AXX1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068359.1">
        <property type="nucleotide sequence ID" value="XM_038212431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212431.1">
        <property type="protein sequence ID" value="XP_038068359.1"/>
        <property type="gene ID" value="LOC119737816"/>
    </dbReference>
    <dbReference type="GeneID" id="119737816"/>
    <dbReference type="OMA" id="HACCVIP"/>
    <dbReference type="OrthoDB" id="6350321at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="132" mass="14346" checksum="854ABAF473DC6209" modified="2023-02-22" version="1">MAHLRVPRCHASLLEMANKLYMIGGFVGDSSASDEKSQSMSTIEAYDESNEAWEFVADLWQGRHDANTVTVGDKAYIIGGMEDENEDPLPNVECFDPLTVSWAQGLAALPSASFGHACCVIPGDVPIKWPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B025</accession>
    <name>A0A914B025_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038069755.1">
        <property type="nucleotide sequence ID" value="XM_038213827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B025"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213827.1">
        <property type="protein sequence ID" value="XP_038069755.1"/>
        <property type="gene ID" value="LOC119738858"/>
    </dbReference>
    <dbReference type="GeneID" id="119738858"/>
    <dbReference type="CTD" id="54888"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="752"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="203"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="815" mass="91537" checksum="99B3BD3FF8E0338E" modified="2023-02-22" version="1">MARRFRRKGKNPKGQHGQGQGQHGQERRKKSGGEQGDTSQGQQHGEENDVYHRYSYGPIEKKNEAFEKYYKNQGIVPAEDWDKFMTALQDDLPLTFRITGYRSHAQHMLSYLKGHYINALLADKTADGEALERPKPMSWYPDELAWQFGVTRKSIRKMPVYKKLHDFLVTETESGNISRQEAVSMIPPLLLDVKPHHRVLDMCAAPGSKTAQLIELVHAEQVYGWPEGFVVANDADNKRCYIMVHQAKRLNSPCCMIVNHDATVFPTIRVPQKEGTKMTSMKYDRILCDVPCSGDGTLRKNFLIWKKWTPNSGLNLHIVQYRVLLRGAELLEVGGRMVYSTCSFNPIENEAVVASVLQKAQGALELVDVSNELPGLQRSPGLTSWKVISETGEVFASPEDIPEDKKQKYKATVWPPSEEEAESLHLTRCVRILPQYQNTGGFFVAVLRKVAHLPWMKQSRAGEEHVQANIGAEASADASIAVTGEPSETREELVDEEPGKEEPLDADSTNAEFSEEPSETPENEKSSENKPDENDANADNEEGPSPPKKRKMYQGYKEDPYVFFKEDDEQIWPQINEFYEVDDKFPLTQLLTRCHGGKKRNLYLVNNGIKSMLENNEGSIKVINCGVKVWSRSDAKDVPCDFRLAQEGIHSIFPYLSAARKINNLTKDDVRTLLSQENPFCSKLDQEARDAANKACQGSLMFVYDPKQRDPESNDMSLVLVGWRGKASVRSYIPKGERQHILRMCDIEIPSDSTATLGRDDDKSDSREGGTRTGTNGDKPWPSASELRPPGVESSDADGDADGGRNQPEEAAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0Q2</accession>
    <name>A0A914B0Q2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038069488.1">
        <property type="nucleotide sequence ID" value="XM_038213560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0Q2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213560.1">
        <property type="protein sequence ID" value="XP_038069488.1"/>
        <property type="gene ID" value="LOC119738646"/>
    </dbReference>
    <dbReference type="GeneID" id="119738646"/>
    <dbReference type="OMA" id="QYTERET"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000078">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mib2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="14">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="705" mass="77310" checksum="5AC221C0B57D4477" modified="2023-02-22" version="1">MFTGVRVVRGPDWEWGDQDGGKGCVGTVVPAQAKDSVTGVFVRWDSGVIAHYRAGGASGKYDLRIYDNAQLRVKHPNVNCDCCPEKGIVGMRWKCLGCHDFDLCHRCYNEGKHDPGHRFTRIETNSVPGFEVPCRSGAVKCRSIGICVGARVVRGPDWEWEDQDGGDGKVGTVSQVCSAEGTYRSWVSVRWPNGSASQYRRGHKGKVDVQYTERETMGDFYIEHLPRLDETKAHSYLDTGDKVRLLDMDHLKLKELHLQRCGWNEEITDFMGKVGEVVMVDKDGDVKVNFGGSSYFIHPLCLVMEKKEEAKRPITGEMMTTLQLKALLEKLGDRPGGSADSGAALFQAAVAGNTTKVLEIINDHPEAVKFQNIEKQTPLQAAVHHGHMDAVTALLRGKAPLDHKDVDGDTALAYAVLGDKPEIVKCLLQAGSDINAANNKDFTPLHQSIVKGHQTCADVLLTHDQQKCDVNYKDKDSNSPLLLAITKNRKQIIRWLITNPETDLRQMNKKGFNSLHHAALCGNAFAVVGILEALPNMINDVTGDGFTALHIAAQNGLSVITLLLVKQHGCNKELKTNSGQTALHLAVDNAHKKCIEALVNSGANVNAQNSDGDTSLHLVMKASIKDIMRVTPLEKLLVLVQQLGDKGVSSAKKYNLVAITVNLIKHGADIYIKNKTGSNVLDVCPNPGVENLLKDLYQRKESNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B131</accession>
    <name>A0A914B131_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069489.1">
        <property type="nucleotide sequence ID" value="XM_038213561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B131"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213561.1">
        <property type="protein sequence ID" value="XP_038069489.1"/>
        <property type="gene ID" value="LOC119738648"/>
    </dbReference>
    <dbReference type="GeneID" id="119738648"/>
    <dbReference type="OMA" id="FRVECEY"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548329" description="Sema domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="7">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="599" mass="66046" checksum="402438068571FBF7" modified="2023-02-22" version="1">MESCRRHSTLPWAIALTWSIICVNAFTTSAERLGDLSDYELASFDNPDILDKTQRRASKFNHFALSDHGDVYVGAVNWLYRLESSLKMIQNVSTCDDSRPDSVMPCHLTNNYNKILVVDSTRPNSLITCGGVYDGICQLRQLQDISNVMMESVPNVAGFEDASTVSMIALGKDGQEMLYVAVTYTGENVNDQGNFPTIARRTLEINRYDQSSLLSAIQRDDSIFFNDPAKHTIFSIKYVAAFAHSGFTYFVASQKEDLNSAQFVTKMSRVCQCGPNLDAYTEITLQCSGSDGSVYSLVQAAHFGPAGPDLAASLGLHADEQVVYTVFAKNQGAPGTSDVPIDHSALCVYRMTDILAAFREAVRGCIQDGNTYSINYLEGSFCSTFGIPILDRYFCIPLTDDAIQTPLFQYAKGIAPVPTTAIIELPGTLMSSIIITIEFNHTIALIGTSRGDLLKVHMESSTASRLYERIGVDTSPVLQDVKVNESTRVLLLLTEQKLVKLREENCGQYTTCGTCIGTDAGNDGDPYCGWCTLKRRCTRYSDCPSADVSTRWLAYNAAINITDVAPYDNLPITVTEQQVRDRCIEITSNLQICYGMIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B136</accession>
    <name>A0A914B136_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070090.1">
        <property type="nucleotide sequence ID" value="XM_038214162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B136"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214162.1">
        <property type="protein sequence ID" value="XP_038070090.1"/>
        <property type="gene ID" value="LOC119739285"/>
    </dbReference>
    <dbReference type="GeneID" id="119739285"/>
    <dbReference type="OMA" id="NWALKEF"/>
    <dbReference type="OrthoDB" id="661220at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029327">
        <property type="entry name" value="HAUS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026214">
        <property type="entry name" value="HAUS4_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219">
        <property type="entry name" value="AUGMIN SUBUNIT 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14735">
        <property type="entry name" value="HAUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02090">
        <property type="entry name" value="HAUSAUGMINL4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42583" checksum="1D6A14CBF5AF9571" modified="2023-02-22" version="1">MAAPARNLQNRAVQVNMSLPVHLTSRDSEQYPELVKLLNALSQHITENGTSCSVQKDLSQAEESLKREKQFYLQFHILHHELQEFIMDQEIAGHDVAPSSSAAQLHEAIKHCLYTAEAADYLHPNPTASDEAQPCTLLGLTTEQLQRANPHHKRLQSLQQQLIPQIEDRLRKKCEELVSFHQSQPDSETDQMAFAKATRLPDLLLSQSSQLEEEERKLKLDRAHRDKQFWQYYQALMDSLGVLEQLITKHRLRLQADSDTITSNWLSARCHAMCLKLRVFEARLLCDTYTPEVVTALKQIKHHLNRAIEERDKDVSRLSQALQAYQSIGMGFDQLVREYEQLQAAIDNKTWALTELKQSLVSDSAAEWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAR0</accession>
    <name>A0A914BAR0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073283.1">
        <property type="nucleotide sequence ID" value="XM_038217355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073438.1">
        <property type="nucleotide sequence ID" value="XM_038217510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217355.1">
        <property type="protein sequence ID" value="XP_038073283.1"/>
        <property type="gene ID" value="LOC119741552"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217510.1">
        <property type="protein sequence ID" value="XP_038073438.1"/>
        <property type="gene ID" value="LOC119741668"/>
    </dbReference>
    <dbReference type="GeneID" id="119741552"/>
    <dbReference type="GeneID" id="119741668"/>
    <dbReference type="OMA" id="HACTAVP"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="241" mass="24963" checksum="21629AFFE8C8B988" modified="2023-02-22" version="1">MSKSRKLGRTGCVDNGGTYIPPDKPEFSGDCTGDGTSPRHQSPSRPLQPLPAVGADGPVDQAGGRTTPPSSVNIHGSAQLKGKRTGKTRKLSDAGAVPIKGRTAKGGPATGRTVPVPGPSTGHTQPEEVLLHGSVHPGPPSPVITTMPGDGLLYGRLIDRTAPAYVTGVGALSAARAIDSVEPNPWDSPRALTLRSEGHASTSDFIRCSGIPVSPQSSATTRSRSSKIEKEPPFSTFFDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGH3</accession>
    <name>A0A914BGH3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074980.1">
        <property type="nucleotide sequence ID" value="XM_038219052.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074981.1">
        <property type="nucleotide sequence ID" value="XM_038219053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219052.1">
        <property type="protein sequence ID" value="XP_038074980.1"/>
        <property type="gene ID" value="LOC119742851"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219053.1">
        <property type="protein sequence ID" value="XP_038074981.1"/>
        <property type="gene ID" value="LOC119742851"/>
    </dbReference>
    <dbReference type="GeneID" id="119742851"/>
    <dbReference type="OMA" id="NHMKCLY"/>
    <dbReference type="OrthoDB" id="10040278at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="10">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="453"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="560"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="798" mass="86742" checksum="BA50D4EB1ED95698" modified="2023-02-22" version="1">MEMTSLERELICPICHDYFTTPLSLPCQHNVCHRCAKEQVAASTAHGHHSSDESLNTATSPTSSVVSLPVTPSRPLTASSLRSSFRRRATVTGTTPTANTPIKALPRDTAGTAASSRRESLPAASPAALTPRRRSSTSVPGAHPSTFYCPTCKEKVELGEKGLNGLYRNFALEVIVDRFKLAAKKAASIPCGVCKARPPWDATKSCLDCKVSYCNECYKHHHPWGTPRAQHEHIGPTNNYRPKTITCTEHTHERVTMYCDGCQKPVCHRCKFSGAHAKHKLSIIERKYAVVKEKMESHLLAIRGKCDELKNGVDTLRGLCGKVEENGAVAKEKLSLALAHLQTTLEHRSSALTQATEEEINRRVVAVRTQLDTYEDILKGCSVVDLAVEMLKETDKACFVQAARPILGRLKETVNVIKEAELSPVHAYHDFNNLNIDDGSAVDALTGLDFVKAPDAPGISTKRCQSYDHVIVEWDPPTVGSPAETYTVEYRKLAVRAEGTRPPTPTTQRRSAVSPRSETAGEDLWTSVHGIRQCRYRLSDLEVDSRYKIRVRGENRVGKGECSKIVIIRTVPAPVLSFKWMSCQPNGTQGPSISKDGQRMTLRPNPTLLSPTGAGPMPSSPIALAPAFCLGDRKLTNGKHYWEVTVDQSPCAVQVGVIGERRSRRLGDPVSHHADGDSGHDSCEELDADHGARAADATALVTYHGGKVYFPNETANKSGKKSGNSGGNGIKPATHTLTSCAVGVCADVERGRVSFFDVDSKESFFSASAGLEGALYPAIVIVGPGVVKSRQLDEMCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGH8</accession>
    <name>A0A914BGH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075368.1">
        <property type="nucleotide sequence ID" value="XM_038219440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219440.1">
        <property type="protein sequence ID" value="XP_038075368.1"/>
        <property type="gene ID" value="LOC119743089"/>
    </dbReference>
    <dbReference type="GeneID" id="119743089"/>
    <dbReference type="OMA" id="HRGVDAN"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="15"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="496" mass="53091" checksum="B02BF44E5D88D0C2" modified="2023-02-22" version="1">MVCLPQARCRWWRYVVPFLFFVQFFLCLGLLFNYSILFVSLQDEFQSGAALTGWLGSLSIALLCLLSPISNLLHLKLSRRAVALVGMTVYCAGLFLTSLVPALGYAFVTYGVLTGVGGNLVTSACVRMLLDWFATGNYSRAAAIGIMGPTCGMLSFSYLLTAAIAHYGWRGALRIFSGGILAIGTLTGLLFAEPPTREDQNDSIIQGTSQDQKNGADNALAMQQIHNGGMEDSGEREVQAADPNSQDVHDGNKDDGEGDNTNVIKATEADDTNTPQKEPMHVDTANSYGLLAMIKDPEPWLWTIGKLLAYLGLSFFNINFASFLEGLHFDVNQIASSIAIYASGELGGKVLMAVVGDRLPFSYLYVLAGSCILSTVTLGLLSIAKTFTAIAVLAVVSGFLRAGVNATSLVVSTELFQQTYGPNGTLTLYLCPIGVGTLLGGLLSGILYDISGDYVLSLIVIAAIFLCGSVALLAIPLRRRIRSRGLCSHETHSIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH91</accession>
    <name>A0A914BH91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075633.1">
        <property type="nucleotide sequence ID" value="XM_038219705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219705.1">
        <property type="protein sequence ID" value="XP_038075633.1"/>
        <property type="gene ID" value="LOC119743302"/>
    </dbReference>
    <dbReference type="GeneID" id="119743302"/>
    <dbReference type="OMA" id="RIFGIYD"/>
    <dbReference type="OrthoDB" id="6154955at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037333421" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="432"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="710"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="842" mass="87286" checksum="8193E824B5111903" modified="2023-02-22" version="1">MFLLILLLWLSSSHCVVQEEPTGATCCGACFQGPAGTPGVPGIPGNPGGIGVQGPLGPKGDLGFGLPGPKGDTGDQGQKGDRGEPALQGPPGKQGPAGRNGDMGEGQKGDQGEQGVEGPQGPSGEKGQKGQPGEATSITPRAPSVVAFSAYRTTSVTGGGGDVIIFDNIESNLGDGYDSQSGVFSCSIPGVYFFTATLQRMSSVHPFVHLKKNGERIFGIYDNHGGYRHQSSNSAVLVLATGDRVWLEFGSSNKGIYSNSDKYSFFSGFLFSNLLCFLLSNSLQVKRRPTVMFLLILLLWLSSSHCVVQEEPTGTTCCSACFQGPAGTPGVPGIPGNPGGIGVQGPLGPKGDLGFGLPGPKGEIGHQGRKGDQGESGMVGPPGKQGPAGRKGDIGEGQKGDQGEQGLQGPSGPPGEQGQQGQPGGASSITSIASSAIAFSADLTTSFTGDNGDIIIFDNIETNMGDGYDSQSGVFSCSIPGVYFFTTSLQRLSSSTRPHVFLKKNGARIFGIYDSHDNYYHQSSNSAVLVLATGDRVWLAFGSSNRGIYGDSSNKYSFFSGFLIHVKRRPTVMFLLILLLWLSNSHCVVQEEPTGTTCCGACFQGPAGTPGVPGIPGNPGGIGIQGPLGPKGDPGFGLPGPKGETGDEGQKGDRGEPALQGPPGKQGPAGRNGDMGEGQKGDQGEQGVEGPQGPSGEKGQKGQPGDATLITPSAVAFSAYRTTSVTGGGDVIIFDNIESNVGDGYDSQSGVFSCSIPGVYFFTTSLQRIESSVHPYVHLKKNGERIFGIYDSHGYRHQSSNSAVLVLATGDRVWLEFGSGNRGIYSDSNKYSFFSGFLIHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHS7</accession>
    <name>A0A914BHS7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075649.1">
        <property type="nucleotide sequence ID" value="XM_038219721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHS7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219721.1">
        <property type="protein sequence ID" value="XP_038075649.1"/>
        <property type="gene ID" value="LOC119743316"/>
    </dbReference>
    <dbReference type="GeneID" id="119743316"/>
    <dbReference type="OMA" id="VIPSAWT"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="766" mass="85349" checksum="72E6D8A1683E2AC8" modified="2023-02-22" version="1">MQYEDILNHIGPFGKYQKLLVFALFLVIIPSPFHFIAQVFLAANTDHWCAVPASQMINCSQLQLAECQEEQKSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNESLNSTDVISCDAGWEFDHSRYKSTINEDFSLVCDRQDQPAYAQSVWFAGLLVGSLVWGSVGDWIGRRKTFILTAILVTISSTVTSFVPNFTAYAVMRFFTAACGYGVHLMIYVLASEIVDPKNRVAATNGIFVAFSSSYMLLSLLAFLLREWRHLQLAISLPFVLTLLGIIVFPESPRWLITKGRYKEAAKIIEKIAQVNGTKAPEDLLDKLSEESKEDKKQPSRIPVTQLDLIRTPNLRKKTLILWVDWFVVNMVFYGISLSTSALGVDDYLAAFVSGAIEIPSNLFCWYVMNRFGRRITLVAFYIFGGVFCLITIFIPLGAGRAAVAMFGKFAISAAFGHIYIYSLEIYPTIIRSIGMGTSSMVARVSGILCPIILILGKYWKPLPLCVFGGSAIIAGVLSLMLPETVGCSLPDTIQDGENFGSKSYNHLLSYHFCSSFAWSELAECQEEQKSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNISFNSTDVISCDAGWKFDHSSYKSTINEDFSLVCDRQDLPAFAHAAFGHIYIYTLEIYPTIIRSIGMGTSSMMARVSGILCPIILILGKYWEPLPLCVFGGSAIIAGVLSLMLPETMGYSLPDTIQDGENFSKGRSFQLCVKGNDDVENESPTQAPIDYLPLSTMDQTPKQPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIA5</accession>
    <name>A0A914BIA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075824.1">
        <property type="nucleotide sequence ID" value="XM_038219896.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075825.1">
        <property type="nucleotide sequence ID" value="XM_038219897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219896.1">
        <property type="protein sequence ID" value="XP_038075824.1"/>
        <property type="gene ID" value="LOC119743478"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219897.1">
        <property type="protein sequence ID" value="XP_038075825.1"/>
        <property type="gene ID" value="LOC119743478"/>
    </dbReference>
    <dbReference type="GeneID" id="119743478"/>
    <dbReference type="OMA" id="IRIMSLR"/>
    <dbReference type="OrthoDB" id="5986703at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="83643" checksum="F0875EC8C0C63EB6" modified="2023-02-22" version="1">MSERLWGVLKARGVQRDTLEKMQNEKIDEDVIIEMTDEELSEYIPRKGDRVVVKAFVRKENSETQTQKRKFTLLESLRSRMAGKSGKKTARLVSDSEEEYESSAPGPSDGGQSNSTQKSAETKRGPRGKKAKEASTSSRSLIVGFSVYEATESRYKQVRAPMGGGIRHITVDKNTPKRKLLHTLCPLFFQDGKNCHGSLGDFQLDVSTDVHGSQPVHENETIQHLIDRLGLKHVRCYLLAKSVDLDEDKSASDPAEDSLEDLPDMFAHRRRRGEENLMPTAIDSSQEEVPSTSDGHHISHGQPNSERYRPLNQGDEMTVDNEVIVQTADDSSPSNNPLLSEAAEDRVELDVQSVFAATLDSDAVNLTPPTYNIPDEFIQEDQLARLNDDDSGIIQFGPFPAAVELDLNATQPLVKEIKVHRGNVCQEMVTFFSKEENVNLRGTTFEVKMLKSDGSTEMAEDNGGVLRDALTEFFDSFYLQYTIGNSVAVPVLRHDMTKVHWSAVGEVIRLAFRQEGILPVRLALPFMQLAFFGTPDDPLDAFMQLLPDVDRLLLEDAMRSVSSVDADDLMDFMERHDARRNLTDENIEKSLTEMANKEMLQVPLFVALCWRPKLKSLGLSRLQLRQIYDNLKPSTRKVLNILEFPKPMNTEEGALSSSLKRLVREMDQNLLGLFLRFCTGSDLAVREKITTRFTESEIRCPTAHTCGCVLNIPRSYAALPYITLKSEFTTLLRNRYWQMDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIJ9</accession>
    <name>A0A914BIJ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075671.1">
        <property type="nucleotide sequence ID" value="XM_038219743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219743.1">
        <property type="protein sequence ID" value="XP_038075671.1"/>
        <property type="gene ID" value="LOC119743342"/>
    </dbReference>
    <dbReference type="GeneID" id="119743342"/>
    <dbReference type="OrthoDB" id="9882192at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="187" mass="21726" checksum="62FC050F2E35660C" modified="2023-02-22" version="1">MVRILTLTLQESFSIYPEVKVDNATSIVLIEIPDEGSKEDLEDETCYTEHNLSLLLQEKESLEKTLEEERTTWAQTEHRMKGTIERLRTKVEYLSNTNMSLKQQLSMIHTSSLKHLTNDSENQSILQELLQHMSEEHTQLLHHHLAQPRLYAQACALSKSAPEESAAKSQSWYQTWLTNHRTSHTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIW3</accession>
    <name>A0A914BIW3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NXPE C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075776.1">
        <property type="nucleotide sequence ID" value="XM_038219848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIW3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219848.1">
        <property type="protein sequence ID" value="XP_038075776.1"/>
        <property type="gene ID" value="LOC119743447"/>
    </dbReference>
    <dbReference type="GeneID" id="119743447"/>
    <dbReference type="OMA" id="SERRIIW"/>
    <dbReference type="OrthoDB" id="2112051at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="362"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="607" mass="68898" checksum="C3239C92C0B7004E" modified="2023-02-22" version="1">MKENGASGGLCPRTAVCHWKTLVPITLIMLATLSYAMALFYQSGQFHLIAPKKVILPPKILPRGQFSLDQSQVPRTPGTQLAASDQNLLLKTWDKTVFNDVDSTAYKNIEAVNSTGRGTSMELTSFKMTHVELVSHVGRSIKVGDVLQYRIQSRDFNGRKRILGGDMWYATLNSDKDPKASTAGHVVDHGNGTYDAYVLAAWPGNAKFNLILVHASEAVYHLRNIVWNSERRIIWLGRYSFKGNTTDAVCYLQHHGKWEGKCEYPAYRALGSTVFLCDKKPDFPCESLYALNIHRQATGDRAKELANGVEYLYKSPYYEQDVPVANSALRIEGSEFQHNKLPRCKADQPIPTLQGYWMNGKWNSLLCEFGTWTEKSSLTSCLRGKRVVLLGDSTTRQWLDGLIKLLNTATVDKPGRRLWSKIHYDSLNLTLYFQFHPYVIGSHTYKLNEMKEEVDVLNGLNDADCNYVVVISPWAHFSQWTRDSYIERVRLIRKAVIDLRRRCPDVPIVIKGPHAKEHKTWEAAMFASDYIFTQIELINREALGGLGAFFLPTWDMNLAYPSRNNVHMPKTIVMEELKIFLGYVCDTLHPHRVGKNLAVPVLHDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJK1</accession>
    <name>A0A914BJK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075996.1">
        <property type="nucleotide sequence ID" value="XM_038220068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220068.1">
        <property type="protein sequence ID" value="XP_038075996.1"/>
        <property type="gene ID" value="LOC119743899"/>
    </dbReference>
    <dbReference type="GeneID" id="119743899"/>
    <dbReference type="CTD" id="9409"/>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="371" mass="42479" checksum="01A1A5A02C7BC70E" modified="2023-02-22" version="1">MEASSSTVCKTWEVFFERYKQTWKWYENWVSENPEVVSQIEKSFRVFSYLLPGAVNVDTVVAELVFSLSNLLVLFHDGILRKARGFTASTLTISAQRLMRWLTVIDHTEVFVELAAAKCWGEAGRWFFIALIQILRSIFRLILLLKCKAGVRSQPPLQPLNRDTDVKPCTTQAQGGEEDPPETAERLVSDAAVRDSGATFRGERSGRVVRSLDAAPNIHQRTWRLPRSEEQDEKESTPPEKEEPTELMGFPLAGESLQIARPLLHLTALLVWGQQSWKPWLLSLAADIGSLRLLNTGKRYNHSERTELSNRSTMLLIYLLRSPCYDRYTRSRLLAVLSSISNTVPGVRLIMNPLMEYLPIWQSIYFYNWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMS9</accession>
    <name>A0A914BMS9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077429.1">
        <property type="nucleotide sequence ID" value="XM_038221501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221501.1">
        <property type="protein sequence ID" value="XP_038077429.1"/>
        <property type="gene ID" value="LOC119745265"/>
    </dbReference>
    <dbReference type="GeneID" id="119745265"/>
    <dbReference type="OMA" id="MITRVEM"/>
    <dbReference type="OrthoDB" id="10072654at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126553" checksum="CD87FAEA2858EBDC" modified="2023-02-22" version="1">MDTKSPFRSSRIPPHFDATTTPYLRAAAGNRGTSQPLSATAASPHLDPSVYHNRHYFSNELMQYHASLANVQKMRQLNASATHFNKTDDCVGRPVESYRPKSIVYGSAFSDPELNWSRAIQETALRDMRNDMLSPNAIGMGQTKRPKHCSVNLTPKLEDQRVVQYHRSGSYNQGVPANLNHLQMQGRPEPQPFANRFALPGMERTPSLDPSCGGRRESAFSRPASHTESPAAYSSLDMEIRRLQGMITRVEMLREKYKHQEGTLQYPRAHHKTHAQGMHGGPFSAAQPSSLMAWYSEEQMQQATRAGNRSSYLSGYPFQQDVSQLFAQKSGPDKDVSKQRAIQQARCATAPVREFPRDYLPDNHKDGMPRIVEVRSLAQGAGQQAMYPEKPQRLYPEISQPKVTFTPKHSIRLSSESSRNETGSVESLDSGVECMSSPTDAQSQRNLASGYGRFKQLEDMYVKDEAVGRPDSHQSLPCHPLSNPIQLCTPPSTSQLERRPGLALSPPLTKTKRKRVIPNTIVETMAKKPKSGIVNSADETKMPEIGPGHASSVPREENNYALDLSLKKGHTQDRNSPKEPLKSLQTQTHSDNGAMNLSIQYKAGVVVRSKSYPADNCPGILHHHGKAASMEDLVALSVKLANEVPRGKEVRDPKENMSQDQQLETRGRFISKLIRRAEGMLLEGPGSASSSRGNGTPESAAPSDIREFKSTTPKTPTENVGEDRNWTTNSPEDHSSKTPDSAESNPKSRMPGTKNPLYIDVMVNEALRIFMSPPSEEEIERHDMSISFDSPSEKGENPVCNSPGPLIISQDETDNDNCNIPAAASLLREPTKTREMGSTCAAVVSEYTGNKPCQCIEKSLSAQNRTAQSPVTFQSQPLHISKPQPTQNSQFQPAEHSKSHPTQKSTTAPQASGSPTRKMKFPDVRVVVRPLQSIAPKPVTKMSPPILIQALPWVQADNVTKVPTAKQESPPSKPDDSQDNLEGSACSAPNFLIPTEDGFRRMQKVDAKIREIYRVTVQPLEVVQSKNPRKQVLKASYSVYYREMNFPCVLRSEVPFVPTQLLVQDLFPGIKASSVCKAMQHCNILNRYMIRHEQEALQDQLRRRGITSCKLLPLDEFHDKWDEILNRIPSVETPEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQF2</accession>
    <name>A0A914BQF2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038078190.1">
        <property type="nucleotide sequence ID" value="XM_038222262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222262.1">
        <property type="protein sequence ID" value="XP_038078190.1"/>
        <property type="gene ID" value="LOC119745719"/>
    </dbReference>
    <dbReference type="GeneID" id="119745719"/>
    <dbReference type="CTD" id="126789"/>
    <dbReference type="OMA" id="ADAFCHN"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="162"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="304" mass="34647" checksum="6FCF4B8AC25D906F" modified="2023-02-22" version="1">MVRYLIHFQYFGTNYCGVVKASKNAIARSGKIGVQDVIENVLEKLNPYRSTKIYVSSRTDSGVHALCNTAHFDLVRPPNKPEAFRDESLCLGLNSFIPRREQVRVIGARRVPDKFHAQHNAISRSYLYRIAVGCTYRSLPVTEKDRCWAIKSELNIEAMKEATKLFLGTHDFSAFRSASKENSFKSPIKTIDRIEIAPSHGLLDRHWSRGHSHIQFWEVSFRSRSFVYRQIRRMVSALVSVGKGSRSLEEVRAVLESCDNAHPKTSPTAPPDGLYLKEVLYNEEDLSLENMQESESSEIVRPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQJ0</accession>
    <name>A0A914BQJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078424.1">
        <property type="nucleotide sequence ID" value="XM_038222496.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222496.1">
        <property type="protein sequence ID" value="XP_038078424.1"/>
        <property type="gene ID" value="LOC119745861"/>
    </dbReference>
    <dbReference type="GeneID" id="119745861"/>
    <dbReference type="OMA" id="RLINCRA"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="265"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="903"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1316"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1416"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1688"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2083"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1451"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1688"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1731"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1771"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1808"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1825"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1847"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1862"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1901"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1956"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2003"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2020"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2053"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2097"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2110"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2185" mass="238371" checksum="9026E7C97F1510ED" modified="2023-02-22" version="1">MMYHPKTPVLMDITSRRDKRMPPTRRLCQASYGGSASSKGTASEMSVGRPSIPQNLPQSLSYLQHHQQMQQQQQLKQQQQQMMQQQQQLMQQQQQQHHLQQQQQQQHHLQQQQQQQHHLQQQQQQQHHLQQQQQQQHHLQQQQADRLAVAAAGMRPPFNPANLRSGTGPPLPVGTSMAGTSAAASFFARAAQKLNLSSKKRKQQQQQHQLQQRLPVFVPDPHAREPEAPLFPTNFSQVIARSPPPAPPSLLRNVARVKDNPGVGKVKVMLRVVPSGNPTDNATFVTVDTKKKQVTLFDPTFLSGFITPANRRAGVAAPKMFAFDAIFPQEASQAEVCSGSVSDIVSSVVNGADGCLFCYGHSHLGKTYTMVGSDKSVHTIGIIPCAIAWLFKLINEKKERTSTRFSVRVSAVEVYGKQENLRDLLVEQANGSNNGCGTSPALYLQEDPICGIQLLNQNELRAPTAEKAAFYLDAAIAARMNKSSKEDPEDSKYSHMLFTLHVYQYRIDKSGKGGVIGGRSRLHLIDLGSGDKSGGKIVNGVALSYSALGQVILALLNNQKHIPNKDSKLTRILREAMGSLSCRTVMIAHVSSAIQSYSETLNTIQLSSRIHRMRKKKSKYSGTSSSGGESSCEEGRIRRHVRPLHSRHQSSGMQVTNALNQSEPEYLSSSEQSCDTVIYCGPDGCALSDRELTDNEGPPSHVPIWRPPILESDEEEVSDLPKDSQTLDKSVADPIYEVIEPEESTKSLLEACQPVSLQQACEGPSPTQTPPTRIPVAASPVKKSGLPVPTRRHSPKSEQPSSPSEKGTVATGTCTEPTASPAEMCRSHDKSRPSVSAKPKVPMRRTQGVSTVMTGESLMEEQDGLPTVLESQEDEAYGNGTLEEKASSEDLTTAVLDQVQCLQWEEDVEKENEDEPTNQEDKTQQMSKEEEQRLKAGMAQHKDLPPILPPKLFLNCSTSKVPPPPPKPQINKLTEPCLESDDDDELSELRNMDKSLCSQLKAVEPETPGGDSLKDGDFLEGFSQKRMSVRERLMLMHSNLGTDSDAILRCLGSIDNLSDMLEKPVSEVSEGDLSIAFSEQDTMSFVSQDTSGAISFDDTMTLDDLPMGSEAICCIKELEQRSIDSFSENFSLSLNEASVNGCVNEPYLLLGMEDRANLSVGNIGHYVYSDDESEIVETGGERHIRRRKRSEYLSEQETYESASLASHDLEAIKSMYVISSLNLEDISLLDDDLLEGSEITMPEMNLQGGYMEDEATVVTYMTINDEQVVMREKHLAIDHPLRRLSCISDATDATFSTTSRPASFMEQDDDNTIVDEENEESTLDNSSSSQWLPKNESLPGLRDANRNWNCSSGGAMGYQAFNLNHQVQGFTGGVQMRTSPQKGLVCLPQLTTNGYQTRPDPRAESPIWQRMDGAVPDHQLSKNGEMLPIPTNGSSNRTVSHSSDRKDSYVSQSTTSSSPKQTTQRSTQNKGVSVTKLAEIESKGVHTSPIHKRCDPVPSESSVLDQVNPTPTSRSEPSSKYDSPQHHARNSSRLRSLSHQPSPLILSAAISRAKEEIEYRHHRNNSRDSDQMARDILLLRRPDGADAKEMDSDCHFNYIASKIQQYELSEETKELAEILSTCSSERPPAIGACSSPAFEVEVNPCFSQELDDALIKDALNPDLPVLDGKLDRESVDEVITCQQCSSSELDNEGSVTAPQVPCKPSRGLVKPKMISSHLPQSESEIQHKNSKNLSAKTSDTSRIPVPPTKSKLLKGSSIPSKIEKGSKLPIRSTSLTSVNSQKNVQNAKTSSKSKASLGPSKSNRSDDSASTTSKSSSVSSRKTVPLTSKIPQSSTSKLSPPGPKPGQKTSQGASSSLPVRNKSLSKSAPSLSKSSGAAAAAAASKIPTSAGASGEKALLRNVNSNISQLQPGNRLTNSSDGSNDSGIASSESVPTPSKRSILSPYSTVTKPRVLRGSSSGHGSDNSSTLSDCQTSNNVTKCRVGGGASSGYESMLRDSEATASGSSCHDSMSECSSARLKNSKLPKKKFPGSRRSRSAPPRSATDSHQGKSNRWKDLPPRPKCHEEGVEIKVYEVDDVQKLPQQRSDAVKSDPLTSTDDRVLKGTKSEASSTTTTSLSSSPNSDPSPPITNPDLAPTAPLPPSPPLLDSQCSLLDQLSFHQTRAVERGARECPLHQYGEAVSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRG5</accession>
    <name>A0A914BRG5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078888.1">
        <property type="nucleotide sequence ID" value="XM_038222960.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078889.1">
        <property type="nucleotide sequence ID" value="XM_038222961.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078890.1">
        <property type="nucleotide sequence ID" value="XM_038222962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078891.1">
        <property type="nucleotide sequence ID" value="XM_038222963.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078892.1">
        <property type="nucleotide sequence ID" value="XM_038222964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRG5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222960.1">
        <property type="protein sequence ID" value="XP_038078888.1"/>
        <property type="gene ID" value="LOC119746154"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222961.1">
        <property type="protein sequence ID" value="XP_038078889.1"/>
        <property type="gene ID" value="LOC119746154"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222962.1">
        <property type="protein sequence ID" value="XP_038078890.1"/>
        <property type="gene ID" value="LOC119746154"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222963.1">
        <property type="protein sequence ID" value="XP_038078891.1"/>
        <property type="gene ID" value="LOC119746154"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222964.1">
        <property type="protein sequence ID" value="XP_038078892.1"/>
        <property type="gene ID" value="LOC119746154"/>
    </dbReference>
    <dbReference type="GeneID" id="119746154"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30282" checksum="79FF8D25B47FD0D0" modified="2023-02-22" version="1">MADSKPKRLALWSTGRCLSTAMVMSFGNYGNVEVFNELYAGAASFGPDATIQFPLPIKVDDEMSYAEVKALLETDYPTRDLVFIKDLASNVTGWYDKLPNGYTHAFIIRNPEKTVSSGIRLSERAGLTVDQYVQLVKSTGMTGGGFGDLVKLAEHLESWLGKPPVILDADDLQRDPEKMLRAFCKALDLPFRESLLKWEPITEIPWTNSKAMLAIHKISGAYENALKSSGWLFSDPKPVDMSGLPQVLRELIDEARPFYEILHGKRVKPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSR7</accession>
    <name>A0A914BSR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079224.1">
        <property type="nucleotide sequence ID" value="XM_038223296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223296.1">
        <property type="protein sequence ID" value="XP_038079224.1"/>
        <property type="gene ID" value="LOC119746381"/>
    </dbReference>
    <dbReference type="GeneID" id="119746381"/>
    <dbReference type="OMA" id="RAQEWKS"/>
    <dbReference type="OrthoDB" id="9982049at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="637" mass="71681" checksum="B8442E35E2D14CF5" modified="2023-02-22" version="1">MTTMASKVSTGVPPNVLQHRNSFTSSKLGNAPPPARVFDCVEHSSDMLKQLSALRTRRVLCDGTLICGEHHFSIHRIILAACSDFFQKMFIENDNIKDIQISSSISRLGLEMLIHFAYTSQLTLTSENVHKTLRAAIQLGVQRVTDLCIQYLVTTICMQNCVELLHLAERHDFDQLRSAVQNFILERFISLSETKDFQTLTPEQISFFIGQDRMVSGSEIQLFNAAARWINHSHKSRMKFAPKLMKHIRFPLISSSDLVDQVESHSFMIENAECHQLLLEALNYHLVPQRQHLMQNARTRMRSTNEVMLLVGGELSNKCVSNNIMILDEPHCQLKHLTSIPLRRVDHCVAVLNDFLYVVGGQVTLTSSGKDSIGTVHRYDPRFNTWLQMCPMQQRRAFFSLVSLAGKLYALGGKNEQGSLASMEAYNPNKNTWDYVQHLPEAMYAHAGCVVGDKLYISGGFTNHNFSKAMFEYDAQRDEWMPRCAMNVPRGFHMACTADDQMYAMGGNHFNSCGERVDVMSVERYNPAHDQWLSVSPMLSGLSMAGVAVMDNQRIYVIGGYSGLARQREKDIHCYTVSKDEWDVVGELAGPALRMACCTMTLTSNLLNLATSDNQSTVSQGTSSLSNFTSVSQQFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT03</accession>
    <name>A0A914BT03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">R3H domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079100.1">
        <property type="nucleotide sequence ID" value="XM_038223172.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223172.1">
        <property type="protein sequence ID" value="XP_038079100.1"/>
        <property type="gene ID" value="LOC119746305"/>
    </dbReference>
    <dbReference type="GeneID" id="119746305"/>
    <dbReference type="OMA" id="HIKEDSQ"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="278"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="5">
        <location>
            <begin position="342"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="823"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="891"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="934"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1348" mass="149493" checksum="876201879757270E" modified="2023-02-22" version="1">MSAVDKTSGLERKVTAKPKLPDSKGEMESKEAKADPKSDGKTELPKPEIKIECVKPEFKRQDSNGTRKVPTLKKDSSFESKKDSGAKDGKVGDAKRTDGKKERPDSLKRDPKLDSPKGRTESIKKHDCSKNVGKKVPVGGRGRGTEREGQGEGIPRLQRQASQEETEAAPVRRRSNPRSKLSRSQPVSDDSSPPHTPDLPLTEQAFMKLPRVDHFSRLPHQLSGDIPPNKICKQHSYEARSEPALSREPSQEKELYIDSSGVDLHQFIVDTLQKPNDRTMLLKLEQELCKFIQNQKEHVRKFPPMTSYHRMIVHRVAAYFGLEHNVDQAGKSVIVNKTPNTRIPEQKFREHIKDEPQDAQAKRILKRDTASFDDKDDEDKGIYEKLEGGVIVLAQLKDDKKSKSYEEREEEYERARARIFNQDSGSSQEGTIMIESPVRESTFNPLLGRPMRTGPLAPSSRQNSGTSDDSTYHWKQDRPWSSVDSSSGSERPSIPAVTKASSFAGSGLSTKILMRNDSSGSSRSSGSLGSRGSLGKLPRVDSSDRGSGSPNVRPSPTFQYHPSLGTISQVQQHLPSYSTAPYSTTPSVSNPQSYQCTQVTWAGSMPGSQGVPLLVQSGSPQGTPQPGTINQPVLFAAPNIESVPPGSVLINPQTGTPFLNPDGTPMVYQPQNVNQQQVMSTQQQQQQQQQQQHMPITSLPNQPSHTFPTQQQMMSQQHAMQQQQQQQQQQQQQQPQPMVSSQHLQHQQMAGQFQAVGGHVGSPGTLSQPCGMQQQQQLQQQQQQQQHGMVHHQHSGEYPDITAQMQQLHFTRQLSGGDGGDIAQQLQQQQHQQQLQHQLLQQQQQQQQQQQHQQQQTQQSVPVAQQYMQSSFVRPVSHVGMGSPGVQGASQQHQPQPMGQPPSQQHAQVVHQVPQSQQVSVPGPMMRPSPPSQLLPQQHSLQGLQQVQPQSQQLPTSSPHQLGLVSPGSQPPGGPVLYQTQGGLVSPQQPMAPPVQQVSYPQGYQGVLPPQQQQQQQQPSQPQIMYQPPMDHQQQQQQQQQQQQQQQQLPPFSQSLPIFYQPANMAGHPALQGGQPEMQQQRPTSPSAPTPVMINQQQLMNYPPGMAGQRPPSQPQQQQPQQQQQQQPQIVTSNPYVQSVPGTLAGHPMPPQTLLQYHPHSRRAYGVEQRAIKGWEMYGPEGSMQSPGVSPSQSPGPTYMRMSPQERGSTRSGQFNKVRPPRAPRRQRKIQHSEAVGQPEPVETPVVPEILEVSNLSADLTCKAVLTLLEDAGKLGGEIRWCPNDGQSPCVGYHQVDPNEQVSNYTVLIRFPSSEASQGALSSLSSASFTLQVPERDYNQRLSHQLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT15</accession>
    <name>A0A914BT15_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079324.1">
        <property type="nucleotide sequence ID" value="XM_038223396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223396.1">
        <property type="protein sequence ID" value="XP_038079324.1"/>
        <property type="gene ID" value="LOC119746440"/>
    </dbReference>
    <dbReference type="GeneID" id="119746440"/>
    <dbReference type="OMA" id="SYSMQDE"/>
    <dbReference type="OrthoDB" id="10476334at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="299" mass="33552" checksum="552C8AEB7358C71A" modified="2023-02-22" version="1">MFSSGSPSNAPVECKTLQHYLINSTCKRAPSIEPTTMENDILSITDSSHHCASVQSEFSTKLLANLNSGMPSDWELNKRKERYQTGLNPSLREFCGHTTCRDTCLFETYQTSREPTPDRDAGNGEDGKPPSLSYLPERQHEYRWDGPPVNTQGDLQRDLDTQQTEPDDVLSGIDYSLSQLVEAEIEAFRVNLHNLISDHHQQHRQLLSPGNEAVTEQRAVYDQPAGNGDANYAWSPMNSSEKPQMEESSSSSYSMQDEETIQLYHPNNSLEDEVNSALLQLLTSASAVSHALRRHEYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXK0</accession>
    <name>A0A913YXK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044479.1">
        <property type="nucleotide sequence ID" value="XM_038188551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188551.1">
        <property type="protein sequence ID" value="XP_038044479.1"/>
        <property type="gene ID" value="LOC119719192"/>
    </dbReference>
    <dbReference type="GeneID" id="119719192"/>
    <dbReference type="OMA" id="RHDINSI"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="355" mass="39946" checksum="2F1915833A85456E" modified="2023-02-22" version="1">MGGTTVNSTIYTTVWTDTEMTVQPFQVYTHYYQRQIIAALCITATCLGIVGNGLVIIAVVVSKKLRTITNVFVVNLSISDLLACSFLPWQAVAVLSEAGWPLHGADWLCVISAAFMFISNGCSTTNLALIALNRWIGITKSVSTTRRIYTRCSIAGMVLFSWIMPICLTVIPTTIGFGQLGYEPKYSTCSWLKDVPMSYIMNILIPIFYFPIQFLVILLCYVSIYRYVIKSSRRMTRHDINSISGATGCVDRAMQKMIWKRQIAVTKNLLHIVLAFVIFVTPSFIAMIPLGYDWSIRMTPYAAAIVFFSSCINPIIYGTSHPDFKETFSRMIFCKKWRNTTQTANVSQPMTQMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY41</accession>
    <name>A0A913YY41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044468.1">
        <property type="nucleotide sequence ID" value="XM_038188540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YY41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188540.1">
        <property type="protein sequence ID" value="XP_038044468.1"/>
        <property type="gene ID" value="LOC119719181"/>
    </dbReference>
    <dbReference type="GeneID" id="119719181"/>
    <dbReference type="OMA" id="DADSFWF"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="320" mass="36599" checksum="16C3D00108BD8495" modified="2023-02-22" version="1">MPGRVNETRGPLSNCSLADVKNRSGVVILSTTNLGFMDMTLNMLESIKRTKVCVNTTVIAEDQKCYRYLSERAKGDPAVHVVLTNSGESQSREIKRSDRRSYYALFNKRQEYVLSLLEQGLEVLFTDADSFWFRDPFPYFRGDFDMSMIDPRSPYPNRTEKTWYCAGFVYFKPTNVTILFVNTWINAMKHNAKIGRLLADQNQMNFLLRVDQPVHVNVQPLDTNIFPWGPKFYELLAKKANYSTVVMHAASIRGHAAKVKKFKSSNMWLVDTFEVSHKNTVSSFHGVSLLLILILALAVGCCCCFCCLYWCCFPDHPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYP5</accession>
    <name>A0A913YYP5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bindin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044688.1">
        <property type="nucleotide sequence ID" value="XM_038188760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYP5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188760.1">
        <property type="protein sequence ID" value="XP_038044688.1"/>
        <property type="gene ID" value="LOC119719343"/>
    </dbReference>
    <dbReference type="GeneID" id="119719343"/>
    <dbReference type="OMA" id="VMEPDEE"/>
    <dbReference type="OrthoDB" id="10072653at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000775">
        <property type="entry name" value="Bindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02084">
        <property type="entry name" value="Bindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00761">
        <property type="entry name" value="BINDIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037504672" description="Bindin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="124496" checksum="9946B10846787C3D" modified="2023-02-22" version="1">MDWPMQLVATLTALVLMSLLCQAEDTTCPAGCRCGIGKASCQKPYNGTQPLPSHTRKLELHAANPIVLKALSRSMPQLEHLMLNHLEGLDGKNDSITKQDDGQRIMTIEGLHKLQKVLIGLASLKTLVMNEEELSCSCDLLNMAEAAYANGVDLYHVIKLLTSQSCKQQGLDLDLHSPLELMLLCSSRSLYLPTALEPKPITPKDEGSVSTSDHSDSKDLGKITHVRARRAAEEKPQKGKKGRKGKKRRKGKKGRKGKKGRKGKKRRKGKKRRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGKPIQPEETPAIPTEIKAAEIEKEPKTEVVVEPVIPEADIAETKIQQIKAEVEPVETKPEIVMEPDVEPVIPETELTETGKEAKAEQVKPVEGKLNLGKGKGKGKKVRKGKKGRKGKKGRKGKKGRKGKKGRKGKKRRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRRGKKGRKGKKGNPIKTEETPAILTEIKAAELEKEPKTEIVMKPVIPETELTETGKEAEVEQVKPVERKLKIGKGKGKGKKRRKGKKGRKGKKGRKGKKGRKGKKRRKGKKRRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGRKGKKGKPIQTEETPAIPTEIKAAEIEKEPKTEVVVEPLIQEKDVAETEIQPIEAEVEPVEPKTEIVMEPVIPEADIAETEIQPIKAEEEPVEPKPEIVMEPDEEPVIPEADIAETEIQPIKAEEEPVEPKPEIVMEPDEEPVIPEADIAETEIQPIKAEEEPVEPKPEIVMEPDEEPVIPEADIAETEIQPIRAEEEPVEPKPEIVMEPDEEPVIPETELTETDKQPIEAEVEPVEPKTEVVVEPVIPEADIAETEIQPIEAEVEPVEPKPEIVMEPDVEPVIPETDLTETEKQPIEAEVEPVEPKTEIVEPETEPVEEAEEEAVEAPVMEPVIPEIEPKTEPEVEAEEKEVETNVEPELGQATEIEEPPEKQPVESESQPAEVEMEQIETKEEPTEPKEELAGIDEKLMKELRDLLESTKIDLPVDINDPYDLGLLLRHLRHHSNLLARIGDPDVKKEVLSAMNENDETDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZK6</accession>
    <name>A0A913YZK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045139.1">
        <property type="nucleotide sequence ID" value="XM_038189211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189211.1">
        <property type="protein sequence ID" value="XP_038045139.1"/>
        <property type="gene ID" value="LOC119719713"/>
    </dbReference>
    <dbReference type="GeneID" id="119719713"/>
    <dbReference type="OMA" id="FISTAMM"/>
    <dbReference type="OrthoDB" id="10030973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="166"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="43864" checksum="7125AAC18A87581B" modified="2023-02-22" version="1">MASTSKHIDTSDALQSILQDDDDMGDCDVESLMSEESGSEVGETSSSDMSISEESDKAKSEDDDYAPPPKRPAHIPPKGRPKTVPAQPQRVQAQPQRVQAQPQTVQAQPQTVQAQPQTVPGQPLEYVAKSGMTWTTDAPPAARRRRANLVTQAAGPKHLGGAKTKLELFQLFFTTTMMNTILMYTNEEGLTQRGRAWSRAIAMMELSSAIGLLLFFGLSKVSRASIRSQWRKGPFAKPLAMATMTGTRFQDILTLLRFDDKRTREGRKKNDKFAPIRGIFDDFAESCRRHYSAGEFITVDEQLVAFRGRCPFRQYMPKKPAKYGIKFWLCVDVDMCSHYVLNIFPYLGKQAEGTQTNLGSKVVKDLVQPLYNTGRNANAKTAVTFSCTTSSWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z101</accession>
    <name>A0A913Z101_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044345.1">
        <property type="nucleotide sequence ID" value="XM_038188417.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188417.1">
        <property type="protein sequence ID" value="XP_038044345.1"/>
        <property type="gene ID" value="LOC119719101"/>
    </dbReference>
    <dbReference type="GeneID" id="119719101"/>
    <dbReference type="OMA" id="CTRARAG"/>
    <dbReference type="OrthoDB" id="6071813at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="683"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143559" checksum="A9F9603A46E744A4" modified="2023-02-22" version="1">MGRADRTSSFRMSPIVRTPEPVQGLHSSHHKSRTQYTDAGHDYVKFHKDRINEQLQRTSHSKAGGASDTFPLKPEEGNCGYCYILADETCMVEDEFNKQSNEQVGADREENNEKAAVLDETEKDHLDNKYLLSFVSLCGLGRKDSSLFKDTEGFLGKYLEDQCSKLKPEDTLKEIVQESEPEKEPDDTQILEERVKKLAEEANKDKIDEGNSKAYQNKTRETDMEDGIVRESKPEKEPDNRQILEESLEKPAEEASDDKRDEANSKADQDKEIGKTDVEDGGPLKAAEELDGGPLISTKEQDGGLLIASEEQAGTKTAEKPDAKQHRGKKNSAKRRKRTRKPNQGVDRVKSLQKKTQKALSITEPAKVKKVANGSGGKGEAKTDGHPNQTNGGNGKTCTRARAGDGRNSAKQSNSDDDEDGDERRKPRHTNTTKKTCGRQAHKRKRPKKESSKGSRSPSPKPGSVKDMDWVSQGTRPKNRPRGGPGGDKSGPRPPKVEKESPSVRKLQQQMQCMSLGRDAHITAHLSENPSPAGKPMPRTRQNHQAVVKMYHDDGIRAHREVALSMPSGLRWRGASAMPGDLQVAMSAEVSPRSVEAQVAEDARADEVPQPPEVPPEVVIPPGVSHGEPRHLMVFADHVRQLKDHVLQLKDHNPEELCGQHEGVLLDKALIVEDGQFRDGLQYTKLDFLGRGSFGNVYLIQDRNSGKKVVAKQVPVRAFAPAEVTLWCVSDHPGIVPLLGVLRTDDMVTFISGYEPGSRTLQSVINQAVLGQGRALRIMGQVLQALAYLHSRQIVHKDIKTDNLLILPGARDRVKVIDFGLATRLTAPEHTDDVLKGTECYMSPEIAGGEAYDARTDVWSSGCTFVCMISGHPPWSQRFKGVPTKLYVIAVSGPPLEDIPHNTDPRVRCFIEQTLKKDFQKRPTAAQAWQILPLDIAEELENTLAIEHDEPEPEPMDVQRDIPEDAFPGPLTPWTPRGPQDGFRPFPQRQDPPPANRPAPDMSLSFLFIPGDGEPRQDKRSDVPNSEMEVDEEDMYGPPPDLDSPETFVKDAFKARPSEVSSGTSSVNPRSVARQLSLNAANFESPFNGHLKDAQQNSQATSSFMLDTAGNPFGFNGDSQSFELEPMSLGGSLEECHSISTAHALMFEASQMPSLENALWNEADVAGAAGFDTSGVDTNSPGLSAEDQHFASLTETVQSTSTAVPGGIVAVVGIEGKEPFRMRLKPDYSGRELAEAIVGLQHYKDSKLAMRAFTLCWKDTGDVLHLNHTFGCGEHQLVAVAAPEGDDWPWWRINNSGRITKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3L8</accession>
    <name>A0A913Z3L8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046394.1">
        <property type="nucleotide sequence ID" value="XM_038190466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3L8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190466.1">
        <property type="protein sequence ID" value="XP_038046394.1"/>
        <property type="gene ID" value="LOC119720674"/>
    </dbReference>
    <dbReference type="GeneID" id="119720674"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="521" mass="59008" checksum="83DF03DEDA2551E5" modified="2023-02-22" version="1">MARKKKGKGKKKAKQNLVTAESEYGKAPHTFVFHRGVVGKSVLQLLLDIRRTMEPYTAASLRTRKKNVLKDFVSVASPLGVTHFMVFTKTDTGTNMRIIKIPRGPTINFKVTQYSLAKDVVSSLKRPNMYASQFRYHPLLVLNNFSKDEPHLKLAATILQNMFPSINVHKVQLNKIRRCVLFNYDPETKLIEFRHYSIKLVPVGISRSVKKLLKTKVPDLSRYKDVSDFFLNAGQLSESEAEQEGPDNEVTVPQSMSSRGNIAAQKSAIRLVEIGPRMQLQMVKIEEGMCEGEVMYHQFVQKTSQEIAEARTLRLQRMKAKEKRKKLQKANVDSKTKQKEEHKQKSLDGIKKKTEQEEKSSVKVAVGEEQEEEEVDDDTEYYRQEVGEDPDPALFPKQKRLPRTDKRKASSQGTRLPQKKFKFSSKSSKDSENKVRKGMKGNTRRQDSQERTSSKTFGKKSPSMRAGKKSGPLGRNANKKFGSPDRTQRRGHPAGKGGATKLKKGKVAGGKVMKKSKVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z657</accession>
    <name>A0A913Z657_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <location evidence="16">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047204.1">
        <property type="nucleotide sequence ID" value="XM_038191276.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191276.1">
        <property type="protein sequence ID" value="XP_038047204.1"/>
        <property type="gene ID" value="LOC119721280"/>
    </dbReference>
    <dbReference type="GeneID" id="119721280"/>
    <dbReference type="OMA" id="RTCQPEQ"/>
    <dbReference type="OrthoDB" id="21182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1220.10">
        <property type="entry name" value="EGF-type module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0168">Coated pit</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037248826" description="EGF-like domain-containing protein" evidence="22">
        <location>
            <begin position="20"/>
            <end position="4553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="4410"/>
            <end position="4433"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1480"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1523"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1568"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1941"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2167"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2212"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="3103"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3232"/>
            <end position="3274"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3275"/>
            <end position="3317"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3318"/>
            <end position="3361"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3362"/>
            <end position="3404"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="3980"/>
            <end position="4014"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="4065"/>
            <end position="4111"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="4171"/>
            <end position="4214"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="4367"/>
            <end position="4397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="4512"/>
            <end position="4553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="4542"/>
            <end position="4553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1057"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1096"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1123"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1135"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1175"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1215"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1294"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2704"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2738"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2745"/>
            <end position="2763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2757"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2777"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2784"/>
            <end position="2802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2860"/>
            <end position="2872"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2867"/>
            <end position="2885"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2902"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2909"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2968"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2988"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2995"/>
            <end position="3013"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3028"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3035"/>
            <end position="3053"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3047"/>
            <end position="3062"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3068"/>
            <end position="3080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3075"/>
            <end position="3093"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3087"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3537"/>
            <end position="3549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3544"/>
            <end position="3562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3556"/>
            <end position="3571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3576"/>
            <end position="3588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3583"/>
            <end position="3601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3617"/>
            <end position="3629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3624"/>
            <end position="3642"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3678"/>
            <end position="3693"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3698"/>
            <end position="3710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3705"/>
            <end position="3723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3738"/>
            <end position="3750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3745"/>
            <end position="3763"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3757"/>
            <end position="3772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3777"/>
            <end position="3789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3784"/>
            <end position="3802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3796"/>
            <end position="3811"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3821"/>
            <end position="3833"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3828"/>
            <end position="3846"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3870"/>
            <end position="3888"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3906"/>
            <end position="3918"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3913"/>
            <end position="3931"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3925"/>
            <end position="3940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="4387"/>
            <end position="4396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="4553" mass="504312" checksum="B2E8D4927A96CE01" modified="2023-02-22" version="1">[encoded data, 4553 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6D8</accession>
    <name>A0A913Z6D8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047378.1">
        <property type="nucleotide sequence ID" value="XM_038191450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6D8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191450.1">
        <property type="protein sequence ID" value="XP_038047378.1"/>
        <property type="gene ID" value="LOC119721386"/>
    </dbReference>
    <dbReference type="GeneID" id="119721386"/>
    <dbReference type="CTD" id="285335"/>
    <dbReference type="OMA" id="RVVTFDC"/>
    <dbReference type="OrthoDB" id="441412at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036699300" description="Cyclic nucleotide-binding domain-containing protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="13">
        <location>
            <begin position="940"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1269" mass="140236" checksum="6B64F34A93D4B8FC" modified="2023-02-22" version="1">MAVQLGASFYVAVLAVVAAQFLRVTWGSAPAHDVAGHPVTAGPGVTNGTVGNGTATEIHAHPPPYEIVFLFGSCVFGALVRTLLQKVPVPYTVVLLILGVGLGLLSDKVPEIGDYTTSVAHMDPHLLLHVFLPVLIFESAFAMDVHTFVKSFVQVCILAILGLLVASALTAVLAMYVFSYNWSFSVSMMFGAIMSATDPVAVVALLKDLGASKQLGTLIEGESLLNDGCSIVLSSVFKEMSVPNHNSTASSVTVYFLRVALGGPAFGFAMAKITTAWLSYIFNDAMVEISITLASTYLTFYFGESVLGVSGVLAVVVLGLIVNAERTAISPEVEVFLHRFWEMLAYIANTLIFMLVGLVITKHALANVDPIDWFYVLALYVGINIIRGLVIAMFSPILSRIGYGLSWRNGVIMTWGGLRGAVSLAMALLVSQSEELDSQMIGSKVLFHTSGIVVLTLLINATTIQWLLKMLGMSDISVPKRLAMANAVRRIQEGQARTFAMLKADRFLADADWTIAVKAAEIHDPYKTTSEEEGLSKEAMSLAQRSSVCPSCHTDVPNEPSPLEYAEMMDEARLRMLKAEQVSYWKQFEHGMLSREAVRMLVGYTETAADQEDGFISVTDLKKNWEIKGIYPYLKLKLEELIRGGKTQEIPDARFAISRVMFAISNHVAFEVSIMAIIILNMIPIIMAFVVQEDHPLYVQYKPGLKISNYIFTVIYSLEAIIKVIGWRKYYIFSNWNKFDLFILIMSFVDIILDETIGDNKGFNPSLLKVVKLIRLLRGLRMLRLFKVLIPKLINFLNGRINLQLSLGYDVGKGFVLGEEEVSKLIDRLVDNDSILDYLKNISETNRLECIRELGMLQRVHPGIAVSVKTRQSIRTVLNHSRDTIRELQGAGLIDEGEAHKLEKVVEIKMKQLMNAPSSIPPPPPENLLKNVPWIEGDKKLIDFIKARAELLHFDYGDVIVREGDIPNGIYLIVSGLVKLFGQSEYLDHELASSHSVTVASGPGHFEDYLSVGNVIGEMGVLTGRPRNATVSCETATQVYYINLEDMQIALETFTLHPSLLYRLWRIIAIRIATPLMLEQIAFQGWTQEKIKLHLERGFLPDLEDEGYSFEIEDTVDDVILIQGRAIDAHTRDELVGPHVIPRSVHRLTFKKDDRNEPKILVVPNQNITLPVLDGRISIHGSTVSVAAIRSNLCLRHASRVRLHNTSSGIGGSGGINRRPSRTSAKKIEAPLPPPKGGFPMRNLESLDPIGYPSPVKGQNGMTYVDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6U7</accession>
    <name>A0A913Z6U7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">No mechanoreceptor potential C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047424.1">
        <property type="nucleotide sequence ID" value="XM_038191496.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191496.1">
        <property type="protein sequence ID" value="XP_038047424.1"/>
        <property type="gene ID" value="LOC119721417"/>
    </dbReference>
    <dbReference type="GeneID" id="119721417"/>
    <dbReference type="OMA" id="CLYIRNQ"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1217"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1252"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1288"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1316"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1390"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="808"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="874"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1668" mass="182458" checksum="D9C61A9BC044465D" modified="2023-02-22" version="1">MSDSASIAGSSVASSTSSGPVPPGSAGGAIQQGLGTNGRLLMLGLRGEWGTVEALLRNAEKGDPEINRQEEETGVTPFMLAVKDNKIVVAERLIELGAHINAKSKDGRTAIHYAAASAKDEITKLLISKKADMTVVGGPANQLPIHMASARTSGGLLQVQQLLKTSGKDARLAKDANGCIPLFLAVESGNISVARELLTHQREEQLKVVRSDTGDSPLHAACRRKEPDLIKLLVECGASVNLQNDEGHTPLHIAAWVGDETTLKYFYLAKADANILDKLDRSPVHIAAENGHTSIVELLVDKFKANVSARTKDGSTLMHVASQCGHPETALMFLKKGVPLHMPNKAGAVCLHAAAKRGHVAVVKSLLQKGALVDAKTKDNYTALHIAVQHCKPLVVQTLLGHGAQVQLKGGKAEETPLHIAARIKEGEKVAEMLLKSGADVNAAMGNGETAMHTAARHGHLLMMQALLEEGGDPVCQSKSGENPLHIAVRRSHYPIVKEIIQFLHNEMSRLDAVMAVNEQSMEGETPLHYAAEITKQMIHYSGEDTDIMELLLKYDADINLITKLTQESSLHYCARAGNNDIMIKMVNHLGPNRTQLAVNRQSKNGWSPLLVASEEGHVDIVKLLLQNNARVDVFDEHGKAALHLAAENGHKENADILLWHKAFVNAKSKLGVTPLHLGAQNGHNELVKLLIGTHNATIDALSLAKKTPLHMAAQCGQLQVCETMLKLKADSNATDMHGQTPLHLAAKNDHADIVKLFLKHKPELVTMANSDGSTCGHIAASKGSVAVIKELLRFNKIGVCTTKNKTNDSTALHLAAAGGHREVVSVLIDNGASPTEENADGMTAIHLAAKNGNVTVLEALKGKVSWKAPSVKTGLTALHIAAHYGQSDFVREMLTKVPATVRSETPASMPGDLKEISIQDHGLTPLHLASQSGHEGLVRLLLNFPGVQPDLPTQILGTIPLHLASQSGHTAVVGLLLSKSTTQLHVKDKRGRTGLHLAAANGHYDMVSLLLGQGSDINAFDKNGWTPLHFAAKAGFLNVVTLLVESGASPKFETKDGKVAICYAAMANHLAVLSYLMKKDHNTQHLMEDRKFVFDLMVCGRYNNNESIQEFILRSPAPIDTAAKLSKNFRLQSAREKERARDLTEASAFCECMAVDLLSVSASTSSAGHLLRSVDSRGITFLDILIECEDKEVVAHPSVQRYLSDLWMGNLTWAPWQIFLLFIIFIIXAPVWVMLSLPLKYRFNKLPIIKFMGYLVSHIYLIVLLCLTTVITPFIEEFIRTRSLIPTWYEWLLLVWLTGLLVSEITNPGDRQGLGWIRVVTLAFSSVACIMHVVAIPFEGDTRLYMIYARNQFFAWCLLFTFTSLLEFLSFHHLFGPWAIIIRDLMKDLVRFMVILLIFLVGFMLHLSAVYQPVYPLTDATSNSTDTIQTPIDTFVILFFSLFGLVEPGDLPSTVRSPPFTLVLVKFVYGTYLIVTLIVLINLLIAMMSDTYQRIQAQSDTEWKFGRAKLIRQMNKSSATPAPLNLITKLVMYCKAAYKHKGKVCSAQARDYINENEEMDAISDARSVDLFGHHTHWLRNVVRRNTQVAPDGGFLRAGNGNGPNRIEEVLDWDKVVRRYLVIKGLEEDPKLNEDTEMEDLNGNSNSNAAQNTNTSKADGAKNSNHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7R3</accession>
    <name>A0A913Z7R3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046880.1">
        <property type="nucleotide sequence ID" value="XM_038190952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7R3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190952.1">
        <property type="protein sequence ID" value="XP_038046880.1"/>
        <property type="gene ID" value="LOC119721065"/>
    </dbReference>
    <dbReference type="GeneID" id="119721065"/>
    <dbReference type="OMA" id="FTINESW"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="136" mass="15139" checksum="C25D1CBB93918134" modified="2023-02-22" version="1">MMSSVILNGVLFATTVWGVHKTLKAASMVHQDRSKSQRASTELVIYLKISCVMGFTWILGCLAQVTSYRPLWFLFAITNSAQGVIIFVVYACNARVRAMWRQRLRRTEAKKSDSAARTTKASTPVTKGHSGNKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8D8</accession>
    <name>A0A913Z8D8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047271.1">
        <property type="nucleotide sequence ID" value="XM_038191343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8D8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191343.1">
        <property type="protein sequence ID" value="XP_038047271.1"/>
        <property type="gene ID" value="LOC119721318"/>
    </dbReference>
    <dbReference type="GeneID" id="119721318"/>
    <dbReference type="OMA" id="HIRSNHN"/>
    <dbReference type="OrthoDB" id="7765404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="194" mass="20272" checksum="8CCD1AA829040EB8" modified="2023-02-22" version="1">MAAAAAPKPAKSPTKKAAKKPASDHPSYDVMIVQAVKDLNEKKGSSRQAIVKHIKSNHNKLTDKADVRIKLALKRMEKKGTLTHTTGSGASGSFLVADAKKPAKKTTKPKPKKVKKPAAAKKAAKPKSSKKTKSPTKSKSKPKPAAAEKKSKKPAKAKGASKKSAAPAKGGKASPKVAKKSSSKKGKGKKSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9E6</accession>
    <name>A0A913Z9E6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048264.1">
        <property type="nucleotide sequence ID" value="XM_038192336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9E6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192336.1">
        <property type="protein sequence ID" value="XP_038048264.1"/>
        <property type="gene ID" value="LOC119722293"/>
    </dbReference>
    <dbReference type="GeneID" id="119722293"/>
    <dbReference type="OMA" id="AVANPIY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="53590" checksum="A95FAD807A333D4A" modified="2023-02-22" version="1">MGNTIEHPSVELPPEKLVMVTGGNTGIGYETAKSIAEMGARVCIACRSEDKAKAAIERMQEEHKNEMQKRSPAENAAAQASSQPTSEEIEIKPLNVEYIKVDLASLQSTMDFIQKTKERMQYLNILVCNAGIAFVKQEYTEDKYESQFQVNYLSQLLIVLHLMPLLRAGAPDSRIVLLSSEAHKGGKLDLDNMQGRKSFSRLTAYASSKAYMVMAAHFLARRLEGTEVSTFSIDPGLVDTNIMNNFSDLKLMSFFVGAYNKFGMMRTPKQGAATSVVACVDPSLRGKTAVFMKNCRPANPATFCWDGKKQEDLWDYSLGCLNQFISDGVLKEAFPSARPDLLTIPKDTRTVEEKIADDSGKKEGSSGDKEMGDKSKGGKASLERKQDEEQPEIESSSGATEVPSKKVKASQEPYGANLEEKIPEDTLKDEDNEPKASSKQEQTEEQPKRELPSAAAELPTERVKAEEKPSGQVSEERGVTDNAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA06</accession>
    <name>A0A913ZA06_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048597.1">
        <property type="nucleotide sequence ID" value="XM_038192669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192669.1">
        <property type="protein sequence ID" value="XP_038048597.1"/>
        <property type="gene ID" value="LOC119722512"/>
    </dbReference>
    <dbReference type="GeneID" id="119722512"/>
    <dbReference type="OMA" id="WILYVDD"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19437">
        <property type="entry name" value="lipocalin_apoD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000003">
        <property type="entry name" value="Apolipoprotein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF62">
        <property type="entry name" value="LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038205194" description="Apolipoprotein D" evidence="11">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="12">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="190" mass="21613" checksum="2F6B44C02B26B6BA" modified="2023-02-22" version="1">MKSSTVFVGLLFAVFAACCQAQVFSWGNCPRVQVKEDFNATKYFGKWYEIMRFNKTSFEEGTRCIYAVYSNGTRPGTVGVRNAALRGTEVETAEGYAYAPDPTQPGKLKVRLSESWFAGNYWVLDTDYRSYAMVHSCTGFWLFNFQLNWLLSPIRNVTSDVVESALQRFETSGIDISNFIRANQTRCPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAA9</accession>
    <name>A0A913ZAA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047825.1">
        <property type="nucleotide sequence ID" value="XM_038191897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191897.1">
        <property type="protein sequence ID" value="XP_038047825.1"/>
        <property type="gene ID" value="LOC119721940"/>
    </dbReference>
    <dbReference type="GeneID" id="119721940"/>
    <dbReference type="OMA" id="AWRFGEF"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF30">
        <property type="entry name" value="EXO-ALPHA-SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="49266" checksum="897FB63D5636BEF1" modified="2023-02-22" version="1">MEADKRLDVKAPPLTEIFGQGDHGYNTFRIPAIVYNRRTLLAFCEARKSSFRDWGSMDLVLRRGILKDDEVIWGDIQVIASMPEYRTMNPVPIVNKRTNSIVLVFVAFPQDLSEADLIKGQEYQQKVLVTKSRDNGLTWSEPRDVSETTLGMMDPRPHIYASGPGHGIQLTSGRLVVPGSVFWKPPHETGFLSEIKHKILEFFDCFYNAQSRSMVIYSDDGGETWEQGGGVPAAFDQEGQLVNANECQIVEFDDGRAYINSRTLGVQTPRQQAFSQDGCLTFNPGELATQLPEPGHTLTKWIPSVRNFGGCQASILGFRAPSSVPPDAYDMTSWVLFSNPASTETRVNMSVRLSRNGCRTWSAPWQLNSGASAYSDLVGYETRTSDRVPVLNFACLYECGSLHPYERIVFQTFTLEKMMQGVGMETKAEPTQDIPESALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAV3</accession>
    <name>A0A913ZAV3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 77</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048156.1">
        <property type="nucleotide sequence ID" value="XM_038192228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAV3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192228.1">
        <property type="protein sequence ID" value="XP_038048156.1"/>
        <property type="gene ID" value="LOC119722181"/>
    </dbReference>
    <dbReference type="GeneID" id="119722181"/>
    <dbReference type="OrthoDB" id="191169at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="48120" checksum="82B00C8E8F31F526" modified="2023-02-22" version="1">MDTLSFGTLIHSIESPKFWTKIYCAVWALRFSAPCMLRLMVHDRTHKLEWELRQREEEIAELQKALSDMQVYLFQERDHVLRLFAENDRLKIQELEDRKRIQHLLSLSSPSGPEVTYFHKEPSTRAIVTQKHPQKRHPHAEGEILGLKAEVPSRPQNNRTRRNAQHRVTANQQQAEPESLLLQIEALQSQMKEQAELSREQTEALLEDRRVRMEEMQTVIERDRSKIHSLNEKLHRTQQMLYDSTKDYLELKYEGRSQERVWMAEKDRLLQELDRCKEQLDVSKDDVLVISDHALEERQTQNLEIEDKTEKLAKRLHLMNQRYEAMEKRRNLEIEGFKNDTRILRNQLKDVEKQLYKVTVGVGEDGDMFMLHNIHQTAKRSKKMQSELLQLKALIYGVETDLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBY1</accession>
    <name>A0A913ZBY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 298</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP298 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049287.1">
        <property type="nucleotide sequence ID" value="XM_038193359.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049288.1">
        <property type="nucleotide sequence ID" value="XM_038193360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193359.1">
        <property type="protein sequence ID" value="XP_038049287.1"/>
        <property type="gene ID" value="LOC119722944"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193360.1">
        <property type="protein sequence ID" value="XP_038049288.1"/>
        <property type="gene ID" value="LOC119722944"/>
    </dbReference>
    <dbReference type="GeneID" id="119722944"/>
    <dbReference type="CTD" id="56683"/>
    <dbReference type="OMA" id="YRKQEEW"/>
    <dbReference type="OrthoDB" id="276065at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021298">
        <property type="entry name" value="CFAP298"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238">
        <property type="entry name" value="PROTEIN C21ORF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11069">
        <property type="entry name" value="CFAP298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32948" checksum="6C1A747244EB0DE5" modified="2023-02-22" version="1">MVKLHIKHGDESQFLYDTTVNTTIDDLIRDLVIIYNGRLKISRLSQEMKELSEHGISLPPNMQGLADEQIQDLKLIDEWQTKCEPSGGATFNKDAIGRRNGYACNEKMKDVISKTVSEATKAVSKDLVQSNMCLTYQTVKDGLDQLRGAVMIVYPMGLPPHDPIRMEFENQEDLAGSQASLDVLEEANASLWFSGKEMQRGKKLSDIVGKNEKTKIIVKLQKKGQGAPGREPVFSQDEQKEMMAYAYRKQEQMKKLETEMDDTHLGSEWADPNSLKRQFHGLRDVKWGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD37</accession>
    <name>A0A913ZD37_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049693.1">
        <property type="nucleotide sequence ID" value="XM_038193765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193765.1">
        <property type="protein sequence ID" value="XP_038049693.1"/>
        <property type="gene ID" value="LOC119723204"/>
    </dbReference>
    <dbReference type="GeneID" id="119723204"/>
    <dbReference type="OMA" id="WELACAY"/>
    <dbReference type="OrthoDB" id="10051649at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037459215" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="278"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="11">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="881"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128966" checksum="6754580EB26154E1" modified="2023-02-22" version="1">MLHILILRLILIVEVSGQVFHRNDWDVRLSGGPHGYEGRLEIRPPNDVWGTVCDKNISVLAIACRSSVALGVCLRLGYLAPYSLSFAGERFDRADLPIWSQGFVCTEQDDQNNISCSLATWNRHPSSCDHSSDVALICISDNLRLAGGCSPREGRVELNVGSAGWVGLSGRQHQNESHVEADLHQADLICKHLGYPIALGLHGTCTNGTADPTLPTIEADTCGPRESSLSACLKSALKSGCEKGTLSHRGRPIEVVCAYDNEIVVSTNSILHRLDFDVRLADGPSRLVGLVEMQYNETGWGPACLYEEPVLIIDFLATAVCKRIGSECSIEFNLVSPDDDPSRGAGIEYLLREGPDSQRHWLRLNEKCRQLGGRYLNVACSLDITSHGVTVNAFPNQTCIGRCGESSSPVQCGCDAMCHTFQDCCYDVTSECPTSTEGEGRNLTGQDLGLTSLLDSSQFYQCLRVSSNQSSAYHLVSRCPDSWAADDVITSQCHLSSNVYPVLYQPLGVPFKNVECAYCHGAAVPPGDGIAGTDALGDSLVPIPASGYDSTLRPCTSLVSTCLSTKAFFACMAYMAPDTKYKNPHCGLCNEFPAYRGVCYKNGRITSLQVMLKGEVPIISPIKPQPVYYVSDRVDPAKFRKGRHEVSLGVTTRIGALETFWNSSSGIDSATCLLNRIAYSDLKLALHFPSSVLDWDFVKETNVVTIATWSLEYTGQLEEELDDILIQDGYPSGVNWADRCGLAQVLLIEKSDLENPAQTTNKSSSESTECYEIDQMNSTLVNISEEIFVYVVPVGALIRPANATITIRYGTQAERTEKFKLFRYCGTRANSITCETRDENNENGRNPDLPDVTLPSGEKLVCFSDNLILTKQDRVSFEDPAQVLNVVGFSLSMAGLMATLVTYSVFPTLRNVPGLAIMSLSLAILVGQLSAILSTVVVDPANEAICTAVAVTSHYVWLAVFAWMAAMSWDLMRTFTSTTSAMTAGGKGRFLRLSLFGWGAPMLIVIPNLALHFCDCTRLVFRYGGRLACWLAGRGSSLLMFCVPIVLCICFNVGCFAWTIRGIRASKKASTMVSRNTSRVQAVWQELVVYAKISSLMSFAWILGFVAVATELTVFWYLFIIFCSLQGVFVFLAFAFSRQVRALWREKLSRPAGTAGSGTSTMCKPSSHVMKTTTGNTGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGS8</accession>
    <name>A0A913ZGS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050624.1">
        <property type="nucleotide sequence ID" value="XM_038194696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194696.1">
        <property type="protein sequence ID" value="XP_038050624.1"/>
        <property type="gene ID" value="LOC119723819"/>
    </dbReference>
    <dbReference type="GeneID" id="119723819"/>
    <dbReference type="OMA" id="FIWASCG"/>
    <dbReference type="OrthoDB" id="5973363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="60"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="295" mass="33547" checksum="A5DE9CEFE34B355A" modified="2023-02-22" version="1">MAGVGTSTVSTIVQEVSESIVNNLWDHSVAKHFPEDEAQFKEKMLDMEEHWQFPCCWAAVDGCHIPIKCPAGGLEACKEYHNFKNFYSIVLMGLVDAKYRFIWASCGFPGNSHDSIILQSTDLWEKLQEGQVIPPYAKTVDGVDVFPIILGDSAFPFKPWLMKPYTDAVLTPKQRYFNYRLSRARMTTEGAYGRLKGRWRVLQRKCESIPENVRSATLACIVLHNICIDRGDTVSTKLDMTNDPATGERRDRDKIRALLHMNLSPPVRNTNRQAETTRSCLATKFWREKEGHGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHI3</accession>
    <name>A0A913ZHI3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050490.1">
        <property type="nucleotide sequence ID" value="XM_038194562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHI3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194562.1">
        <property type="protein sequence ID" value="XP_038050490.1"/>
        <property type="gene ID" value="LOC119723740"/>
    </dbReference>
    <dbReference type="GeneID" id="119723740"/>
    <dbReference type="OMA" id="EFACRIC"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="318" mass="36634" checksum="08883F5F1E863E77" modified="2023-02-22" version="1">MCTMAEKSATTYAHPDFCNSPIDYSIPSYSYVEEESLSPIKNRARSWSEDAEDLRVDRVRRRSTGSVGTASQPSLRLSLHRCGECPYATKRRTNLERHRQAMHSRDKQLECCGSLFSSKSELRRHVRHQHESGYGCLQCGRLFCRKALLKRHMSVHNGVKEFACRICSYASSHKSNLERHERVHDKQKPEHTRSRTKEAAILKAQQVVRDYVRDREVDKIMTHLNSLYHKMADGGTAEKQLKHTSPSTSFTPLGPKRMFANPYKCLLCNLRYQSQESLKKHERELHPDLEVQAFLSLPMKQVLHLMRLAGVRVAVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI30</accession>
    <name>A0A913ZI30_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051443.1">
        <property type="nucleotide sequence ID" value="XM_038195515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI30"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195515.1">
        <property type="protein sequence ID" value="XP_038051443.1"/>
        <property type="gene ID" value="LOC119724452"/>
    </dbReference>
    <dbReference type="GeneID" id="119724452"/>
    <dbReference type="OMA" id="HDEWEDE"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037116308" description="SRCR domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="134"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="263"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="397"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="508" mass="56402" checksum="6FA721D1ABA15C9C" modified="2023-02-22" version="1">MYQAIILLLIMRATVNAQDHDVRLSHIGGKQGRVEVLNNGQWGTVCRDGWGFFDALVVCKQLGFPWLFPYGWHHDAGNGTGPVWLSNVRCKGSETRLDECANDGWMEHQCADASRAAAVKCLDHDEWEDEFAEIYLADSGGFQDRAYEGRVMVNLHTDDWQQRFLICDQGWDLADANAICRMKHLPSALRATTSSYFGKYDPHITTYTHALNASYLATDFACTGNESHIAQCPAKAWFLDECPTGRTAGVICNRIEESEEFQLRLVGGSTPNEGRVEVFTNGTWGSICLDGWWNIRYRESNVICRQLGFGYGLETTTDDRFGRTDGPVAISGFIRCAGGESSFAQCYISTLVHYDYVYNPPDAECFNKEDSYQAGVICSGPVPESRSPVRTSYNGGGHVLIHHDGRWGTICKAGWTLANAQVVCRELGLRAPKEALEDGHWPGDGPIFLSGVSCKGDEETLDQCDLGEWYQHDCTHSMDVYLVCAADCVANSFIALLTSLVTALWLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK36</accession>
    <name>A0A913ZK36_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051445.1">
        <property type="nucleotide sequence ID" value="XM_038195517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK36"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195517.1">
        <property type="protein sequence ID" value="XP_038051445.1"/>
        <property type="gene ID" value="LOC119724457"/>
    </dbReference>
    <dbReference type="GeneID" id="119724457"/>
    <dbReference type="OMA" id="GHIGVWA"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087662" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="77"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="234" mass="25839" checksum="0B3D35B6469B4C5B" modified="2023-02-22" version="1">MIKMKYPLVAIFAVVAQCCLFAAAAHEHAHGDSDSVLEAALRPLYSQLDVFRDQLDAVKVFVHVPCKKAKYPTDLECSEAGPLGMEDGRIPDANITASTFWSNSAAWAPYRGRLNLEGAAWLYAGSSDPNPWIQVDFGGRVIITGVITQGRPDNYNQWVTEFQVAYSNDGQQWTDVTAEGESAPTKFPGNSDRSNPVTTTFPKALQTRFLRILPTEWSAHCSMRLEVLGCKSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKA4</accession>
    <name>A0A913ZKA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052247.1">
        <property type="nucleotide sequence ID" value="XM_038196319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196319.1">
        <property type="protein sequence ID" value="XP_038052247.1"/>
        <property type="gene ID" value="LOC119724971"/>
    </dbReference>
    <dbReference type="GeneID" id="119724971"/>
    <dbReference type="OMA" id="YGFPICS"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="491" mass="52188" checksum="0127A51595C6FAD6" modified="2023-02-22" version="1">MENKVEINASLSIEYVNSSGETPPNGAPPTSSLANKDRADEENDNIDKRSEEKPAGTKFTYHQKATFASAMMASLSNMMAASIISVFYPIEAKAKGMNQTVIGLVFSAFALTAGIGSPIWGKFIPVFGARFIFLAGAFVTGGCNVLFGFIVDMPTRATFTAFSFAIRLLEGLGSSATKTASAAIVAFTFPENVGTAVSLIEMTGGLAYAIGPAIGGLLYDAGGFRFPFFALGGLVLAIDIANFFLLPQQGQKKEESGPLTLVLSIPAIWLALLAVFVAAISLTSLVPTVPIHLKELGFTVLQISFIFLSFGLSYAISSVIWGAVADAKKATRIMMVFGAFGSALFFLFLGPSQLLKIPSTKLLAILVIPTGTVMMGLFIMPTFVDMYISAEWYGVPTNLGVTSIIAGLWNGVFAFGSLVGPLLGGALTQVYGFAYATTIFAGALISVMIVLCLFGVWEYRCGKGRRVPRSRLEMQANTTDEEQVPLIPNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL41</accession>
    <name>A0A913ZL41_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052044.1">
        <property type="nucleotide sequence ID" value="XM_038196116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196116.1">
        <property type="protein sequence ID" value="XP_038052044.1"/>
        <property type="gene ID" value="LOC119724846"/>
    </dbReference>
    <dbReference type="GeneID" id="119724846"/>
    <dbReference type="OMA" id="LINWESE"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037127416" evidence="8">
        <location>
            <begin position="24"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="652"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="925"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="959" mass="105224" checksum="AE96962E64C0499A" modified="2023-02-22" version="1">MAAGLQQLSLLLVTCLCCADAQGTTGSPSATDLDTDTTLSNTADGPTTPAAMEIPYACPTQRNTWHSCSKMRGCLQRSWERFYCQCDHLCVTYGDCCPDYEEYCGVGTFGISVTTVGVGVIDGDRRSGIENTAEYMRCIQTDEFDPEGSRPRSGFWLVAVCPPDWTGAAAVTELCEKTVGMDGLAAVPVTGFDRRHYRNVYCAMCHGLPHTNVTFWTISYVDKTKSFNSFIPNRIVLQIARGQVPSDDFQKLFSPPNFQDAEYLSSFMLRTCRILDAISCPISDPRAVELCQRHYAPITWNGTTYRNFACARCDDTPIPPTDILSTWCTQSLDGGRGGSMATLLVFSDRDTTCTHRQIYNPFSSSCLDLSCPEGFALRDGGVGCARIRETENESTGLKSNVEVALTVMVSLDMDTEAQHTNRLNEIWEEVAHQAAKDYQSTTSLCELDEEMTENNQVDRDDELCDDFSVQWSCTMDVAILDSTPGCLSGSVLACSINVSFNSLSPLVDHIIAQNDELSSQCFVSRVGNHTMRPEYLAVLTPCDNLSNDTEEESNFNNAFTLKVAYVRDKDSGHFVVSQNDSCAELLVDCPLLTFSKDDYVITGALNDSIRLTAHDRLLRSGEFEIKSDGDVEVCNFLQPSADPPYMKFGPAQDILTATGSSLSLIGLVVTIATYVAFPSLRRNAAGRALMSLVAALFIAQLTMLIGLDRTDVPTLCVTFAISSHYFWLAAFFWMNILAVDIYRTFGIGTSLSDPNKRSFFRYALYGWGAPTVIVATVAVLSFCDCVDADVSYGTARACWVGNGTANLLSFGLPIVVILCSNAVLFSLTVAGVKRTRMASKRMNITQGQSGLAAKRPNNDLFLYLKLTAIMGFTWVFGFVASFSGVEFFWYLYIVLNSTQGALVCLAFVCNRRVLAMWRAWLDSRRGRPGASASGRGQRSSKSAVPQQSQAESVTKGTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNL1</accession>
    <name>A0A913ZNL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052964.1">
        <property type="nucleotide sequence ID" value="XM_038197036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197036.1">
        <property type="protein sequence ID" value="XP_038052964.1"/>
        <property type="gene ID" value="LOC119725573"/>
    </dbReference>
    <dbReference type="GeneID" id="119725573"/>
    <dbReference type="OMA" id="KWDESSI"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22860" checksum="B0DFC0EEE10B4734" modified="2023-02-22" version="1">MAEKLTENPKRGILKASGHYEDPANKPEDGIKWDEMNILATFHPEGKDYGHMKVDEPDTPYNKYTDPDGDDADADPQSENEDDKVLDSGKLANRLQTDTEDRRWWDKEPGEEDDESEDEDEDESLMSPEAKDLKRKFEVHRKQHYDEASKMKLAKQLMEQDEEELKQLEEEEERERLRAGEQTSSSLDDANSSEVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNQ3</accession>
    <name>A0A913ZNQ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052676.1">
        <property type="nucleotide sequence ID" value="XM_038196748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065856.1">
        <property type="nucleotide sequence ID" value="XM_038209928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNQ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196748.1">
        <property type="protein sequence ID" value="XP_038052676.1"/>
        <property type="gene ID" value="LOC119725350"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209928.1">
        <property type="protein sequence ID" value="XP_038065856.1"/>
        <property type="gene ID" value="LOC119735953"/>
    </dbReference>
    <dbReference type="GeneID" id="119725350"/>
    <dbReference type="GeneID" id="119735953"/>
    <dbReference type="OMA" id="APVHIIQ"/>
    <dbReference type="OrthoDB" id="441971at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="266"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="37509" checksum="6493B0668DA7DEBC" modified="2023-02-22" version="1">MRTHKLNTSSYHPQCNAIQERFNSVILDTISHYVNTCHNDWDQYLTSVQFAYRTTPAENSVGFSPFFLLYGREARLPLDVTLLTNSNYPEKTLREHMHHLVSQLEVFRDVSKRHAELNQAKMKERFDEKAQKVPYQIGDTVWIYIPAFQKGLSRKLMKFWAGPYLLVEQTSPVNFRVRNLENNKLLSSPVHVNRMKFAYNRYVRPSNDSVPFDPKQNTSILGLQEDDCPQNIFHPLTAVHQSSESESSGIPFVPGLPQISEKPKEYEIERIIRGRYKNKRLVYLIKWKGFPHSKNTWEPETNLNAAALEFLKTHPVKISGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRI3</accession>
    <name>A0A913ZRI3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054009.1">
        <property type="nucleotide sequence ID" value="XM_038198081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRI3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198081.1">
        <property type="protein sequence ID" value="XP_038054009.1"/>
        <property type="gene ID" value="LOC119726428"/>
    </dbReference>
    <dbReference type="GeneID" id="119726428"/>
    <dbReference type="OMA" id="WYFNFSN"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="42117" checksum="EB3DB0541A93E1AB" modified="2023-02-22" version="1">MNASSEQRTDCTPEHAQLVLTSDNISSYTYSSGDTTVICVVMPIILAIGVLGNGTFLFVVARVNWMRQVSTNIYLACLALVDITFIAMAVGGKLSRFLASPIVTDESLLGVPGCVLLYFVSDLCFYVSLFLITLVSLGRYSAVCQPFAFRSSSEGRKGVMSRIAWCWGISAAAACILIPDRLVWEETCITLSPPDEFHHLPQVIGSCTSVVEWYFNFSNFVQVAPFFTTMFVNFTLYALIIRKLRQQAEMRQGLSNETALEQAQVRDNITRMLIVNGTSYFVFLMPFEALALGVTIKSLSGTPSLLTKDQFSLALNICRCLLYTNSAVNPFIYTLMSPAYRRAFADALCPASTSQGASVQDLIGMSNINTKARRDSERRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRZ5</accession>
    <name>A0A913ZRZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">creatine kinase</fullName>
            <ecNumber evidence="2">2.7.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038054412.1">
        <property type="nucleotide sequence ID" value="XM_038198484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198484.1">
        <property type="protein sequence ID" value="XP_038054412.1"/>
        <property type="gene ID" value="LOC119726690"/>
    </dbReference>
    <dbReference type="GeneID" id="119726690"/>
    <dbReference type="OMA" id="FTRFCEG"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000001">
        <property type="entry name" value="Creatine kinase M-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000002">
        <property type="entry name" value="Creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000005">
        <property type="entry name" value="Glycocyamine kinase beta chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF23">
        <property type="entry name" value="CREATINE KINASE B-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="141"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="397"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="510"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="771"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="884"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="336"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="513"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="677"/>
            <end position="681"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="705"/>
            <end position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="887"/>
            <end position="891"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="950"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="995"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1055"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1084"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126085" checksum="6A2D70C268D9842B" modified="2023-02-22" version="1">MSANMGCVVTKNRDGGGSTGAGGSGTPVFVQTASDNYPDLSQHNNHLAKCLTPDIYKQLFDIRTSFNCDLDRCMQTGVDNPGHPFIMTVGMVAGDEECYEAFAPLFDPVISDRHGGYSASAKHVTDLNPDHLVGGELDPKYVVSSRVRTGRSIRGYALPPLCSRAERRDVEKIMVDALASLDGPLKGKYYPLTGMTEKEQDQLIDDHFLFDKPVSPLLTASRMARDWPDARGIWHNDLKNFLVWINEEDHIRVISMEQGGDMRAVFSRFCEGLGKVETSLKSKNYEYMWNEHLGFVLTCPSNLGTGVRAGVHLKVPLLSKHAKFDEILSKLRLQKRGTGGVDTASTDGTFDISNLDRLGTSEVQQVQMVIDGVNILTEMEKAMEAGNSIDDLIPGSKANPDLADYPDLSKHNNYMSHCLTPQMWKNLKDKKTSSGYTLKDCINTGIENPGHPHIMTVGVVAGDEESYDVFAEFMDPVISARHGGYDKDAKHRTNLNPKDLRGGENLDPKYVLSSRVRTGRSIRGYALPPHCTKEERAAIEKITVDALAGLEGPLKGTYYPLEGMTDETQEKLIADHFLFDKPVSPLLTAAKMDRDWPQARGIWHNAEKNFLVWVNEEDHTRVISMDKGGNMKAVFTRFCEGLQKVEALMKAADKEFMWNEHLGYVLTCPSNLGTGLRGGVHVKLPLVSQDPRFDKILYAMRLQKRGTGGVDTASTDGTFDISNLDRLGTSEVEQVQCVVDGVELLINMEKALEKGNSIEDLLPAACKPRPPAKIMSSNYPDLSKHSNYMAKCLTPAIYDKLYKLKTKAGVTLDDCIQTGVDNPGHPFIMTVGMVAGDEESYDLFADLFDPVIDARHGGYPKTAKHPTDLDASKLKGGDDLDPEFVLSSRVRTGRSIRGITLPPCNTRAERALVEKVCVDALAALDGPLKGQYYPLTGMTEETQDKLIEDHFLFDKPVSPLLTASNMARDWPQARGIWHNDEKTFLVWINEEDHTRVISMEKGGNIKRVFERFCGGLKKVEDAIKSKGHEFMWNEHLGYVLTCPSNLGTGLRAGVHVKVPLLSKHDKFDALLEKLRLQKRGTGGVDTASTDGTFDISNADRIGVSEVQLVQMVIDGVGLLVKMEKALMAGQKIDDLLTSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSA0</accession>
    <name>A0A913ZSA0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054643.1">
        <property type="nucleotide sequence ID" value="XM_038198715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198715.1">
        <property type="protein sequence ID" value="XP_038054643.1"/>
        <property type="gene ID" value="LOC119726862"/>
    </dbReference>
    <dbReference type="GeneID" id="119726862"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="27594" checksum="B4B27DF9AC432000" modified="2023-02-22" version="1">MFANTKKKISEKADQEIATIRQKEQRLLEETDRIYQERITTFDAAQANNRKEVTQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKHPKQVSDQLTFMDFEEDERSLGRLILEEEPKAAAKQSPRPRRSCVMEKWKLKTEVKNFELTNALIAHVTALSNNKLLALYESKFLFANTSIPAIFTVSLPNSQPEPSPIPQMLQINGLSDDVSFYTSAIYFMCVCFLQERLFESNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSV8</accession>
    <name>A0A913ZSV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038054275.1">
        <property type="nucleotide sequence ID" value="XM_038198347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198347.1">
        <property type="protein sequence ID" value="XP_038054275.1"/>
        <property type="gene ID" value="LOC119726605"/>
    </dbReference>
    <dbReference type="GeneID" id="119726605"/>
    <dbReference type="OMA" id="NCPPDEQ"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="18">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="423"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="447"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="550" mass="59136" checksum="BCACBB9ABB9AF07E" modified="2023-02-22" version="1">MADYVVSSEGKTPHPAIDDGLTGSTLFTSGDGLTYNDFLILPGYIDFTSDEVDLTSALTKKIILKAPLVSSPMDTVTESSMAIAMALCGGIGIIHHNCTPEFQANEVRRVKKYEQGFILDPVCMGPDDTVGCVFSAKVAHGFSDEEQSQKKSKSIFGIPITETGSLGGKLLGIVTARDIDFLKADSYNTPLKEVMTRREELVVALANVTLKEANVLLQKSKKGKLPIVNEKDELVSLISRTDLKKHREFPLASKDSHKQLLVGAAIGTREDDKVRLELLAQAGVDVIVLDSSQGNSSFQVNMVKYIKQNHPDVQVVGGNVVTASQAKSLIDSGVDALRVGMGSGSICITQEAVPSITKNPMTLQEGLRANVLMAVGRPQGTAVYKVSEYARHFGVPVVADGGITSVGHITKALALGASTVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLDAMESNKASAQRYFSERDKLKVAQGVSGNIVDKGSIHKFAPYLIAGVQHGCQDIGAKSLTQLREKMYSGELRFERRTTSAQVEGSVHGLHSFEKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUP3</accession>
    <name>A0A913ZUP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054975.1">
        <property type="nucleotide sequence ID" value="XM_038199047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUP3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199047.1">
        <property type="protein sequence ID" value="XP_038054975.1"/>
        <property type="gene ID" value="LOC119727186"/>
    </dbReference>
    <dbReference type="GeneID" id="119727186"/>
    <dbReference type="OMA" id="AYITANM"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF18">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037645223" description="JmjC domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="130"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54249" checksum="6F28B88AEB8DEF99" modified="2023-02-22" version="1">MKITKIISVIIICIMVFLHQSVAEDAQSSSPPTSLPGHLKPLASEATRLPVSVIQDFPSPYEFFRSYVYPSVPVIIKQGARRSPAFQKWTDEYLKSLPESQQLIRVEMRKVEERQLPRMNMPFAEFLDRYQTTDEYLVARVPDFLKKDVLIPPSLHCTNVTANLLETMLWFSSGGTKSHVHTDYVDIINCLFRGQKDFLLVNYTRYREQIIYDHPEGFYSSVDVERVDLNKFPELRNLEFYEAKLQAGDCIYLPFKWIHQVNSFGSNVAVNIWWNHQAYVVPSPESCGMPDPGLDISLADVRFPYHDQTDTGIDFLRDLHPEVDFVRNPSASLRAFMDEEETESLTEQQFLEFMDMMLSGPEGEIWTEEALHVAHQMFQMLDTDGNGEITSQDMDTFPIKINKFDTFFINLGQKMMILCDIADGQISKQVQEILNKFEEDKVRDVGDTPSHEHGSKYRGTSGHTPMRKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVE0</accession>
    <name>A0A913ZVE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055041.1">
        <property type="nucleotide sequence ID" value="XM_038199113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199113.1">
        <property type="protein sequence ID" value="XP_038055041.1"/>
        <property type="gene ID" value="LOC119727252"/>
    </dbReference>
    <dbReference type="GeneID" id="119727252"/>
    <dbReference type="OMA" id="YHICLAG"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF421">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="326" mass="37055" checksum="38ED41F233044525" modified="2023-02-22" version="1">METTWSSTEGITVTTNTTGDENEFTSTTLLIFVKVLAVLAIFLCVLLNPLMLVTLRRVTSIQPTTKIFMASLTLSDLCNSLCWILPLTELFAGSWLLGDFLCVIYIVTSYLFPGLIMFCLLILTVDRYIAISHPLRYPSIMTEFRSKIIVFSTWAAQSIICLLGFGIPGSRIVSLDTRYHICLAGFDWRQYLSFTLLVFTILSILIMYAHIAVIARNQARRIAAENQAGNGQGGQRINTRSTTTIIIITGTLIITWIPSVIRLVIDSQNQWEPYDSYLAMMFTNVLLLCNGWLNVIIYYLRNRDLRQAVRTLVSDWHQSLQQRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVF4</accession>
    <name>A0A913ZVF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055249.1">
        <property type="nucleotide sequence ID" value="XM_038199321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055250.1">
        <property type="nucleotide sequence ID" value="XM_038199322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199321.1">
        <property type="protein sequence ID" value="XP_038055249.1"/>
        <property type="gene ID" value="LOC119727443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199322.1">
        <property type="protein sequence ID" value="XP_038055250.1"/>
        <property type="gene ID" value="LOC119727443"/>
    </dbReference>
    <dbReference type="GeneID" id="119727443"/>
    <dbReference type="CTD" id="23154"/>
    <dbReference type="OMA" id="IVHYKKP"/>
    <dbReference type="OrthoDB" id="8186546at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="80588" checksum="79DDCE02C2A9FEE9" modified="2023-02-22" version="1">MDQQGVQTNDVDMESCSASSDGLPQPTERVDTCLQALERASSDTEVFAALLLVAKIVQAENTDAATRKRIFDAVGFRFINRLLKAAAKPDKKESSTYRSLAVTLLGCFSTSPELVSHPQMVNKVPVLIEVIQEARTSVEDNEKQTIDDAYQILVTMAMEESPRKVLCSPEVISALCGMMQGSFYGCDRAEQVLLLLLHHCGQHVWRLNKPHMDALLYKLASKFKECQDEAKFQVCETLSRLLSAYPSVPMEQSEWSPLVFRGVSDILMSKVSEKQRDPALCLASLMVSHYGMSWALGPNRLDKKFLLLLIHLACVETRMALESPDHQYRTSKESVLVSCFSLLEQCIEYLTCGPPLALDDRQVVQLHTAMTGAFGAVMFYLQGAQYQESWPDQPLVVAAVRVLCVWLAEETTALKEQVYQLLPFLIKVVDKSFKEVTNSRSHANAAAAASTPQQSLRSFASTDLLRLLLPALCHLTAEDEPRARLVEEGGIELLGECFSYHWKRFVDGDEDGDSEIALTTLCSVFLNVTLQDAEAVQSHSTVFKELLCLLAAALAHTVTNTEHLILSFNFAVLGLTLLRTLAHHADTQNLSAIKKFVGRTLDLFRASFRVASDNVHEVCEAYQPYWADVNELWLLGIQVLSECLMCIPWLPSMCLQSGYLQHIIGLLKIVVAGTVEEETIIVYSALLGSVAKTEVGAQLKQMGALDIARKYKMEELSMSLQMDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWR7</accession>
    <name>A0A913ZWR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056093.1">
        <property type="nucleotide sequence ID" value="XM_038200165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200165.1">
        <property type="protein sequence ID" value="XP_038056093.1"/>
        <property type="gene ID" value="LOC119728092"/>
    </dbReference>
    <dbReference type="GeneID" id="119728092"/>
    <dbReference type="OMA" id="YWPARTW"/>
    <dbReference type="OrthoDB" id="6782814at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="480" mass="54083" checksum="7767F4EDC363C0F5" modified="2023-02-22" version="1">MIFMYLDDWLVVGRSRGEMEVALQLTWQLASDLGFLINTKKSHPVPSQVPTFLGASLDLRGGLARPSEDRLLNLRQCVSLFLPTVVAPARAWLRLLGLMASLVDLVDFCRLRMRPIQLHLLSFYRPRWHPIDHPVPTMSWLVPHLRWWLVEANITQGRVFRPPRPSVLITTDASGYGWGATLHPRQVAGVWGPAHQSSHINILEMLAVTNALKHFQSDVRGQAVLVRCDNATVVAYINHQGGTRSGHLCALTWDLILWCIHHGIALSAVHIPGEENVTADALSRGWIAPTEWSLLPQVAQSIFRLIDRPHVDLFASRMNNQLPIYCTRGPDPNAWQTDALSVRWDGLLAYAFPPISLVSRVLTKIEQEDCRILLIAPFWPRQPCFPRLVRLLVHRPVILPRRADLLYQPSSGINHQAPGDLHLTCWVLSRDPSAQQAFRDELQQLQPSPVEPQPERCTIADYAISLNGVDGNPFIPPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWU8</accession>
    <name>A0A913ZWU8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056123.1">
        <property type="nucleotide sequence ID" value="XM_038200195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200195.1">
        <property type="protein sequence ID" value="XP_038056123.1"/>
        <property type="gene ID" value="LOC119728119"/>
    </dbReference>
    <dbReference type="GeneID" id="119728119"/>
    <dbReference type="OMA" id="PRVEHSH"/>
    <dbReference type="OrthoDB" id="6038945at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18563" checksum="FA706189813E4932" modified="2023-02-22" version="1">MNAYRLIPLLQINVARLVCLLGIILLLTTLITPGIGSKNRRQSREKKHRDRTDKRQTDRYSVSWDPQPPVGPPAPDYCSCSWEYYDHEDAQRIPRHLHFARCTNPNDDCRDSSEGSCHLHNYTVAVLRRSSTASRCRDSLDDYEVAYESVPVACVCVLPDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXY9</accession>
    <name>A0A913ZXY9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038056513.1">
        <property type="nucleotide sequence ID" value="XM_038200585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200585.1">
        <property type="protein sequence ID" value="XP_038056513.1"/>
        <property type="gene ID" value="LOC119728369"/>
    </dbReference>
    <dbReference type="GeneID" id="119728369"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="66"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="515" mass="57779" checksum="C01E1F8E7D3D0A97" modified="2023-02-22" version="1">MALTWTKLVFLRRLGCRWSPLSVAAQHLCNDANIQIAEEVAKLLELKAQIGDVGTNQKFILKTPKGTRDYNPKQMAIREGVFKTIVDSFKRHGAETLDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKINRIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGQYDPMIPDAECVKIVHEILTNLGLGDFVIKVNHREILDGMFEVCGVPADKFRTICSSVDKLDKTFWEDVREEMIEEKGLDPATADNIGQYVKMNGGLELVEQLLQDPLLPTSKAAKQGLEGMRTLLKYCQIFGVLDKVSFDLSLARGLDYYTGVIYEAVLKGSEMLPTKTGEQVGVGSVAGGGRYDGLVGMFDPKGKQVPCVGVSIGIERVFSIMEAKAQAKAEKIRTTETDVLVASGQRDMLEERLKLCTELWDAGIKAEMIYKKNPKMLNQFQLAETTGIPLIAVIGEAELKNGTVTLRNMETRAEEQIPRADLISVIKERCRQISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0Q5</accession>
    <name>A0A914A0Q5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kringle-containing protein marking the eye and the nose</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057402.1">
        <property type="nucleotide sequence ID" value="XM_038201474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0Q5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201474.1">
        <property type="protein sequence ID" value="XP_038057402.1"/>
        <property type="gene ID" value="LOC119728995"/>
    </dbReference>
    <dbReference type="GeneID" id="119728995"/>
    <dbReference type="OMA" id="QECYCEA"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195905" description="Kringle-containing protein marking the eye and the nose" evidence="11">
        <location>
            <begin position="21"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="14">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="226"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="69502" checksum="EFF03E6863422A39" modified="2023-02-22" version="1">MEIRCRCCFLLLVLSVEVSSQDPIELTDVRLYTEGGLLFGGAVEVRTPNGWERVCYDGFDSQMADVVCHKRDFDEGAMAVRSSASLGIEVNPLPSLACQFTTADGEEVVQCEYASTCSDHVVVICNYPGYLGCYPHTRTNPALDEASFAFANMTVQLCLSLCRQRGYPHAGVAFGQECYCEAQGVDGLASERLGNEECFLPCVGDPLQICGGGKAVGIYDSRLGSCNSIYTDVEGAIATPGFPDKYSNDEQCTWTVRVDNAANITVQLRAVVLAQGDRVGVAAPQAAELVAFTGGANPSNIGFESTSHILDARLEFTFTGGEVTVTFNSTLTSLGAQGVVITFWSSIGPPTDRSMQINMTQPASTVTSHTVPKTTTAGPTTTTTTTTTTTTTTSPESMTSRALPTTSSFSPTVATDDDDNATTATAAIAPNTATVDGALPTPRSVTMVNGGGSREAPSIAVIVAIAVGIILILLLFLTVAVLFTTSHKHDRKRNRRHNHNVHVNAAYAMSNDNDGQTDSGIFDPGYENADLGEPIYLSIRNDHRARADLKSAYYGGSDQEQDSDHSLSRTASVKTTKTDVDHDYQSVYRLSRSNTESSYISIYPDSKRSTFIGGRVSPIQGSSGTQCEVAEDGYMVPTPKNSTQIQQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0U3</accession>
    <name>A0A914A0U3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057442.1">
        <property type="nucleotide sequence ID" value="XM_038201514.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201514.1">
        <property type="protein sequence ID" value="XP_038057442.1"/>
        <property type="gene ID" value="LOC119729025"/>
    </dbReference>
    <dbReference type="GeneID" id="119729025"/>
    <dbReference type="OMA" id="WHINSTS"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="3200"/>
            <end position="3289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2691"/>
            <end position="2711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3289" mass="359741" checksum="3755C14EA209DF44" modified="2023-02-22" version="1">MRQCIKQCSWRSNSNACFPGSCTNGQCRCSSGFSGTDCRTLGSSQAPVLSEHRATLVNGTTTRESPSVQGSTDTVYTNVRDFTSIRANWKSSYQPTGLPAYSGGGHPYIQSIRFGVVWARVTAAVNRGNRVIYSVGSQACTTSTTGNSFNRNNPATYLVSCQVTFNLNYNSWTPATGDVLRYDVYSTSGGYMKLYNRDNSNSIITRYYTRRTTSGYSTFTFDFVDPYHCVDVGSGCRTTMLYAGNDVTSQAEIIVTWQGWADSLAGIKEYELQVRQLSGSHGIKMTEVFDSPAVYSGVTDSSQSITLPHVGVYSIVLSVVDNTGNVGLSRRFVFFDDDPQDVTLQDDSSLRVVSATAETNYEWMTSLDSSGGMTSVQLDWTNRFINLYHLNQGLLKPIGSYDAGTIDSNYDQNFGKRGRAAIPNSLGVTEFRVVHDIDHSGGRTTVKVSDNNSDHWSSEGTDTQATYDLTLVDGDSIRFWVEARDLAGHFVRDSVLVHADSSPPVIEDFWLVRDGEVNLAVHNSEDLDKMSVEFRTYDIHSGIRTIEWLLFDNHTGTDMTHGSQNLKAKKINTDTEDCDPVSCMCVPIGDCYAIDYGFHPTMHIGTHDYDYYITLTVTNQARLVTTRTIKITVDASAPQAGVVHDGIPGSNEVDFQEGSDLSAHWEGFFDKESGVKFYQYLFDDSCRTGNTTVGSASNDMTRTTSTYASWTAPSPGQYYITVIAYNRALDPSKAVCSDGVVIDTSPPELTQIAISYARMWPGLAKDAEGRVWFINEHRRKMELMNASRDCSSMAALVDDLSVYPEIAGSNDSSAILQGDLDCVWISPIEQKFFLPIDKHLTISWTGGIDTESSIYDYEIGLSSDPSNPTPDLVTFMSTSGHDHFVMYHPHISQGAVFFLVLKAINKAQLSTFKVVGPIVVDTTPPMFVGRVSVHVEDDYLIAAWGDDGFIDDEDTSLRYQVAIGSSPGGTETLDFKKEKAYKIGPCLSRTSCAAFSLADLDWHLHGDHEYYVSVRAQNGAGLATVGTSSVYRHIVQLPSLGVVLDVAPPGEEVHVDLGVAKDIDVQMSTASISARWFGFEHPHLDINYEIAIGSEGGASDVSVGFIDVGNATFYQLDGLDLIPLMTYYVTIRANSEAGSVNVTSDGVKVIQEGQVLEGAGVKDGLGCDQDETSTPPGLSHLSSAAHQPCEDDITYQSSTSDISARWTIPEMLQPFVTGVFWAVEQEIEIYFDDENTTMEWIPVIDDQDLGMSFQHVGAGVGLHGGGHYRSKVQFCHVNVCFKPVVTDGFWVLSQPPEVGQVTVSDVEATPGGTEIRVVFQPFAHGYVRHDDPRELMDFYEWSIAEDGSDGALLSQWTRIQDLVVTGDVARFTASLSGSLDLDVCLQLSVRGYNKAGLSSIASTEIVDCDNVKLIVPHTVIDADHEVNMEQNAMWPEPDKNYISSTSSLSAVWPTLRHRDYVWAAIEDTGSFGNLDDGLQFPCDHPRSITCGSTDKEFVNVPGLVLHHGKRYRICIHADEVTLEHELWNELLPAVSSCSDGVVIDTTPPTPGAVWIGWNQHQTYQSCSSELVLQWESFTDIEEHGLASHHSGVKYYEYAIGSMRGGSDVIEFTRVGITNSVIVHNLRLQNGHTYFATVRATDFVGLSSQAMSDSVTIDMSPPVFSADHSLDIGGSFIRSTTSISASWKNVFSDKESGVAYYEWAVGSHPGHADIMPFTRENTEIGVSDPSRPLHLHEGHSYFISMKAINTVGLITLKSYGAFTVDAXPPLAGHVFDGNPTDAPANHRDRDFQEDRRVIRAFWEGFHDPHSAIVGYSWRTGMCPGCSDVVTEQHVGLDTDVLAENLNLVPGLTYYVTVTACNAADLCTSVTSDGVTVDDSPPVPGRVYDGGPGGGDISYQSSRRQLQAHWWGFHDPHSGLSHYEWHAGTTPGAADILPSTRIELSEDALIFLSAADQMPVGTDIYITVRAYNRLGTWSQATSNGFRVDSSPPDVVHAPAVDVTRGMAVRNTQVLRDLIHFSWKFSDPESGIKDQFVSVSTHHNGDVNIPSIKIAGSELDYTFTNLTLHEGSRYIVTVVACNMAGLCTQAKTEPLLVDGSPPSVGTFAVSTESAANLERHHIIWIDPTEPSTTPDGTDYSGWMTWLEDPRTSLGSLALAWLGFADVHSGISHYLVSAGRTYSGSELTPNGPVRVNHRNDGMSLDEGIAQTAIIPLEGSITDPSHPYLYISIWAVNGVGIPSSRHHSTFEASPTLPDEGSLVLLRRCFPTTCKGHCACAPIDRTCNPYQYCTDVTHSNPNTEIEVLDVLDLMNDDINNVIDIDDTATQSMAAAVWRVTEQKGLDIKWFEWSIGDDSSSDPVGIFDPVQDRLWYDIGQNNQTIITLDEDHKMEKGVTYHVFIRVWYNPTTYAVFRSDGITPDITPPKISTVRGAKIKDLARSEARKDTDYLTDPNVLFISWERVFLDDAMSHYQVSLSTCPGGEDIRQFADHTFPASVSSTQFTNLNLKSGLRYYSNVRAFNKAGLHTLKSSDGFVVDTRRPDAGLVFDGIDLHDVEYQNSSTLISASWHGFVDLESYIDHYEWCVGQTSSPADDGILPCTNVGIHLSASKTLAVPLTDGIRYYSKISAIDAAGLQSASVSSDGFVSDTTPPEPLVQINLGDNLIKNPSFERIQEPDITDMEYEYTTVIAENETLNEASGTSDPNHGNVSDTYPTSATNLSTEEMSSTTSVHVTDGKQGEVLVQWDVGSDSQFAVVTSGKKIAQDGHSFLSLHGSISQTFNTTXGSHYQVVVFASHPVPSHNPLLNQEGRIEAPGLDRIFRLYDRPAHSHSDQSLRSIQWHQHRFYFTASGDVATLKISSVGRSNGILLDSVQVRQITTWPSTGEGSVEVHTQFIHSWSSIQAKWHFIDPESPIVDYTWAIGTTKGGTQLQSFTSVGTQTDAINTDVMMAHGFYVYVTVMARNAADLITIATSDPILVDLTPPMIHFVKDGGDGHDIDFSADDSSLTFTWSASDPESGIDHCEWAVGSEPGLDDILPSSPSPDAESSITTSLSQAMVEGQRLYVTITCYNVAEKSSWKSSDGVTIVTVPPSSSAAVVNLKTMSETQYDTRDRYQSQRDSVKASWDGFMDPFGIQSYECHLSGPNAFTFWSPCGSTSETHLDWSGLSLVDDATYSLSVRAINHAGLISQAITGNITIESTKPAGGALSLLSHSWLGDGRVNLTWEGLFSASPSSSLVYEVSLGTIPGGSDIMQWVETMETGMRVSPLAPITDYHLTLTAINAAGLSQTVTKIISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2J5</accession>
    <name>A0A914A2J5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057591.1">
        <property type="nucleotide sequence ID" value="XM_038201663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201663.1">
        <property type="protein sequence ID" value="XP_038057591.1"/>
        <property type="gene ID" value="LOC119729139"/>
    </dbReference>
    <dbReference type="GeneID" id="119729139"/>
    <dbReference type="CTD" id="203076"/>
    <dbReference type="OMA" id="YQFVLCR"/>
    <dbReference type="OrthoDB" id="6103133at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF2">
        <property type="entry name" value="SIMILAR TO 4930578I06RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="36060" checksum="31B47ED2CE648DC1" modified="2023-02-22" version="1">MAASMSPEEAEQVALLPKPQGRLKLAQCLRWDLSGFSEEDHMRESILLDYLHDSLLFAAGRGFPLHQVCGVLNLAREMQEQTIGQPLSHAIRLYRQKSVEYAKRGRISDKNLKIFTSHFFATFMRHYRLYQFVFTRPRDPMVSQLGLEVQPPPDTFELKESKPEHIWQYNQKLAAIENEERTRMESLQLERDELLRQEPDTNEPLCALNEAGAPLQEEVLSRAIREATSLQGTYTERLLQARVEETHEDMDYYFEKTALPRPAALGPPPRSKSPPRAPARSKTASTKSGGTGGKNSLGSALPKGSAKSLRSKTPKSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A363</accession>
    <name>A0A914A363_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thiopurine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.</text>
            <dbReference type="EC" id="2.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.67" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038057811.1">
        <property type="nucleotide sequence ID" value="XM_038201883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057812.1">
        <property type="nucleotide sequence ID" value="XM_038201884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A363"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201883.1">
        <property type="protein sequence ID" value="XP_038057811.1"/>
        <property type="gene ID" value="LOC119729278"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201884.1">
        <property type="protein sequence ID" value="XP_038057812.1"/>
        <property type="gene ID" value="LOC119729278"/>
    </dbReference>
    <dbReference type="GeneID" id="119729278"/>
    <dbReference type="CTD" id="7172"/>
    <dbReference type="OMA" id="AVDIVWD"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000101">
        <property type="entry name" value="Thiopurine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF22">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="37185" checksum="68B1F647EB8355C0" modified="2023-02-22" version="1">MSTVAAPLENGFCNGSDEGATSAKRIKLGPQLTSEIRTTTAKPAAATNGHTTAKPTERRKSATACSTEKAKVAENGHREAGNVEEKVTSTASEVTVRRNQDGEVSDGHVTTEDWKTKWERGKTKFHKAQVHGMLKKHFHRLSQEKETPRFLVPLCGKTVDMIWLLERGCGVVGCEFVELGVQQFFAENNLEYTTESLPEDVGGTVYKGKDKDITIYCTDFFKLSSALIGQFDCIWDRGSMAAINPEDRQRYRDIITDVLKPDSRYLLDIFEIPHDVFSGPPHNMDPKDVTQLFGDLCTVEHLEHVDAMNPWSKTWGVNYFYENDFLLTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4R9</accession>
    <name>A0A914A4R9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058710.1">
        <property type="nucleotide sequence ID" value="XM_038202782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4R9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202782.1">
        <property type="protein sequence ID" value="XP_038058710.1"/>
        <property type="gene ID" value="LOC119729991"/>
    </dbReference>
    <dbReference type="GeneID" id="119729991"/>
    <dbReference type="OMA" id="CENKECM"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="581" mass="66120" checksum="56435366BAA74064" modified="2023-02-22" version="1">MATGGTAEVLGKIGERHLECSICLTRFTEPKFLDCLHTFCLNCLQNLRQGEDPQGVKLKCPLCRHETILGRKRVENLPTNLTLGALVEEFTIQEQLLKGQGSEIRCQSCDAENAAISFCMECPHFLCQNCKRTHERLPASKFHKTFTMDQLRSGEVAYKSKLREEPKCDKHADQNLNIYCKTCEQLVCTTCSVLKHEKHSRFDISEAFEECKQEISDLITEAEQRKTALCENKECMVKSHKKLDSMFESTNKKISQKADKEVARIRETEKKLKKEAKEIYKNRVKTFETAENNNNKKLREAEQTLGEVNQLMTQEIQNEILGLKPKLLQNLQKLMEKQQENVPDKLHYIDFHEGDEKTLGRLILKDKWRLKKQIVYTGTTDSVAVFSDEIVTVNESSKELVSHVPSSSRKSPVTSQKLNMPDLRDPHQVAVNQLDQLIVLDGPVIKTFSREYELLHQFQPGRGSDSKPTCLAVDDNNLIAVGYKAKHEISLHKPDGTLLKKLPAPGITDQLAISNKHLIYIKSKAEDKLAALDYNGEAVFEVPEDSGGLLKSLCCDSQGNMYVFHNPLYTRMDHLLAMVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5I2</accession>
    <name>A0A914A5I2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058666.1">
        <property type="nucleotide sequence ID" value="XM_038202738.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058667.1">
        <property type="nucleotide sequence ID" value="XM_038202739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5I2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202738.1">
        <property type="protein sequence ID" value="XP_038058666.1"/>
        <property type="gene ID" value="LOC119729948"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202739.1">
        <property type="protein sequence ID" value="XP_038058667.1"/>
        <property type="gene ID" value="LOC119729948"/>
    </dbReference>
    <dbReference type="GeneID" id="119729948"/>
    <dbReference type="OMA" id="CKDIACY"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="89" mass="10270" checksum="C36EFD998C9E65FD" modified="2023-02-22" version="1">MSERKAVVKNADMAEDVQQDAIECATQAMEKFNVEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAVLLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5R2</accession>
    <name>A0A914A5R2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059068.1">
        <property type="nucleotide sequence ID" value="XM_038203140.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059069.1">
        <property type="nucleotide sequence ID" value="XM_038203141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059070.1">
        <property type="nucleotide sequence ID" value="XM_038203142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059071.1">
        <property type="nucleotide sequence ID" value="XM_038203143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059072.1">
        <property type="nucleotide sequence ID" value="XM_038203144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5R2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203140.1">
        <property type="protein sequence ID" value="XP_038059068.1"/>
        <property type="gene ID" value="LOC119730311"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203141.1">
        <property type="protein sequence ID" value="XP_038059069.1"/>
        <property type="gene ID" value="LOC119730311"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203142.1">
        <property type="protein sequence ID" value="XP_038059070.1"/>
        <property type="gene ID" value="LOC119730311"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203143.1">
        <property type="protein sequence ID" value="XP_038059071.1"/>
        <property type="gene ID" value="LOC119730311"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203144.1">
        <property type="protein sequence ID" value="XP_038059072.1"/>
        <property type="gene ID" value="LOC119730311"/>
    </dbReference>
    <dbReference type="GeneID" id="119730311"/>
    <dbReference type="OMA" id="LEMKEHT"/>
    <dbReference type="OrthoDB" id="9439254at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000623">
        <property type="entry name" value="Zinc finger protein 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="53257" checksum="70B5039A964BCBB8" modified="2023-02-22" version="1">MCGKAFALQSNLTTHDRMHTGEKPFVCETFGKAFVCQSSLVHHEKVHSGEKPFVCEICGKAFSLRTHLKSHINVHTGEKPFMCEICGKAFPRRGLLIIHERVHSGEKPFVCDICGKPFSSKTNLKSHIMVHTGEKPFVCETCGIAFSTRGVLTRHERVHTGEKPFVCETCGKGFSLRTNLKSHIRVHTGEKPFVCETCGKAFATRLTLIRHESVHTGEKEFVCEICGKAFSRRSILTEHVKVHTTEKPFVCETCGKAFSISRYLKSHINKVHTGEKPFVCDTCGKAFYTEGDLIRHERVHTEQKPFVCEICGKAFVCQSSLIDHEKVHSGEKPFVCEICGKAFSLRTHLKSHIMVHTGETPFVCETCGKAFSTRSALTRHEKVHSGEKPFVCETCGKAFARQSTLIRHERVHTGEKPFVCETCGKAFSTPGVLTRHERVHTGEKPFVCGTCGKAFSARGYLHKHGRVHTGEKPFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5S1</accession>
    <name>A0A914A5S1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059153.1">
        <property type="nucleotide sequence ID" value="XM_038203225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5S1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203225.1">
        <property type="protein sequence ID" value="XP_038059153.1"/>
        <property type="gene ID" value="LOC119730366"/>
    </dbReference>
    <dbReference type="GeneID" id="119730366"/>
    <dbReference type="OMA" id="TRNRCMY"/>
    <dbReference type="OrthoDB" id="6355676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="253"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="52979" checksum="00F5B942D70D43DE" modified="2023-02-22" version="1">MKMLLAECAAKNEEVSSSGHLGNMAENLKNDGGVQVDVTTAKTANTRGTCLVCGDTSTAIHYGISSCEGCKSFFSRAIANHESFTCPTKTCRINKATRNRCMYCRWKKCIAVGMSKDRSKLGRRPRKSRVSRSVPSALAGKSADVGSGTYMYSSSAASDQAGQDPWQTTSSQYASSPGMSKTTWTETPPHCEPLVPFEGSCFAGNSTPATHLPATGEGSCGIRKKTAESPSNSIDFADRVFDHWNSIYKYLSKEGTYINVVERADLEHIQFEAVEDRRQIMSILLSNFDPSIRDFIKFMKLISEFRRLDVQDQIILIKENMYEAITLHQAFLMGNSEIIHVLSSAHSVRIPLSLTVTELALWNMLRATSDVGRQMMRLGLNGQHACVLGVIAILATDRIGLKNVSDIERLRSLTLEALQQLIMRTHQENHREVFSKTILLLPSVREINCDHRNLVLAMSLEMPQRMPDLHREVFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5X5</accession>
    <name>A0A914A5X5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038059267.1">
        <property type="nucleotide sequence ID" value="XM_038203339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5X5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203339.1">
        <property type="protein sequence ID" value="XP_038059267.1"/>
        <property type="gene ID" value="LOC119730446"/>
    </dbReference>
    <dbReference type="GeneID" id="119730446"/>
    <dbReference type="CTD" id="63826"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="44"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="349" mass="37895" checksum="6E92BE5D7D885E9D" modified="2023-02-22" version="1">MLRGRSLHLSSLVYSKKPINIMSVTDQGFTIDDVRQAEQRIKGYATKTPVMTSHRMDAKAGRKVFFKCELFQRTGSFKFRGAVNFLSKLLEQSKDGPAPCVTTHSSGNFAQSLALASNLLGAKAYVVMPSIAPQCKQDAVKEYGAELILCTPTEQGRVAAKDKVVEEKGAVYAPSSQHHDIMAGQGTMFTEMFEQVDEKLDAIIAPVGGGGMLSGILVAAKTLQPGIKVIAAEPELANDCYQSFVAKKHIRQDHYPNTVADGLRISLGDVAWPIVRDLVDDVITVTEEEIKESTKLVWQCMKLCIEPSAGVGVAAVMSDKFKALSPDIKNVGVILCGGNIDIDSMKNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6Q6</accession>
    <name>A0A914A6Q6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Malectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059096.1">
        <property type="nucleotide sequence ID" value="XM_038203168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6Q6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203168.1">
        <property type="protein sequence ID" value="XP_038059096.1"/>
        <property type="gene ID" value="LOC119730331"/>
    </dbReference>
    <dbReference type="GeneID" id="119730331"/>
    <dbReference type="CTD" id="9761"/>
    <dbReference type="OMA" id="PNPYSMD"/>
    <dbReference type="OrthoDB" id="10013439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="12">
        <location>
            <begin position="44"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="31698" checksum="01A23F46A132F14E" modified="2023-02-22" version="1">MSKRLFSDHFRTCHISMMFTTYLAVLLSCFVCYISVHRAAATEVVFAVNCGGPGHRDVHGVDYEGDPLDIGVASDFGKNLAVIGRVPQQDAILYQTERYDVNTFGYTTSIEEDGDYVLVLKFCEVWFGASRQKVFDVVLNDLHTVVSGLDIYDVAGRGTAHDEIIPFSITKGKLKVQKEASTFHGDLHIEFVKGDYDNPKVNAIVIYKGTVDDIPKLPPLPGADLDEDEPEDSDDEETEEHKPKRHITSGPKTPDPYAADESSFLYPILIALAIFIPTLFCLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8Z1</accession>
    <name>A0A914A8Z1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059889.1">
        <property type="nucleotide sequence ID" value="XM_038203961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8Z1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203961.1">
        <property type="protein sequence ID" value="XP_038059889.1"/>
        <property type="gene ID" value="LOC119730897"/>
    </dbReference>
    <dbReference type="GeneID" id="119730897"/>
    <dbReference type="OMA" id="SERTIMG"/>
    <dbReference type="OrthoDB" id="9940536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="39186" checksum="6A578FFAD9299D4F" modified="2023-02-22" version="1">MGGCNESKVVPAPSSADEISSGMIKNKSFSFWKFFKNRRSMNRVAPALPEDQPITDVSERTIMGTNKVLPPIRPSSPADRDSSPSPTFSDVSLAPYMITEGTADGDELLELETAERPPTPYLFVVGTPLFAKKISNKEKLHARQESQEILRDLRNSGIVARPETRAGGLTYEYFVKEKFEFLKKPPARLQKLKKAKKLREARGDAKLREEVESRMKMAEERRKNVIDKVRIQQTQHLVLDIRRAHDNSAALEEEKIQFTAERLQQKEVMSRVVQGRATINRDLRNMQQKHHHTEVRLRAALKKMAHRDEEFHQTRKIIVVSPMRGVKPDQSEEEEMAGDCNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A946</accession>
    <name>A0A914A946_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038059949.1">
        <property type="nucleotide sequence ID" value="XM_038204021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A946"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204021.1">
        <property type="protein sequence ID" value="XP_038059949.1"/>
        <property type="gene ID" value="LOC119730953"/>
    </dbReference>
    <dbReference type="GeneID" id="119730953"/>
    <dbReference type="CTD" id="23475"/>
    <dbReference type="OMA" id="FHELDCW"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="503" mass="55272" checksum="A929D5C067D42426" modified="2023-02-22" version="1">MGKWGKYKKKYNTKWEGKPGIKDWIGRVPNDDTKVMCRYCKCRLRAHNNDLHRHAQTSKHRSYAGPKASAPLEYPNGLSSYNNMASFDIPNVLHPTAVEEAVKRWLLEDTPSFDHAGFVVGDLEETAVIMCKSPGVLAGVPFVDAVFNELDCWVQWKYREGAELYEVPCEVATITGRARRILLGERLALNILARASGVAKKARRFVQLAQAHNWHGEIAGSRKTTPGFRMVEKYALLIGGVSTHRYDLSSMIMLKDNHIWIAGSITKAVHDARRVGGFSSKIEVECRSVPEATEAALAGAEIVMLDNFEPQAAKDAAANLKDLFPQLIIEVSGGITDANITQLFSPCINVLSSSTLVQGYPAVDYSLKIIKPGHDPRNPTVTMPRSSSMQVDPITSQALINSMMLSGDGSTTRVVDAQGLVQEPQGLVQQPQGLVQQPQGLVQEPQGLVQEPQGLVQEPQGLVQEPQGLVQEPQGEELETTTVIITTTEDNISIMESTEHNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADX0</accession>
    <name>A0A914ADX0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062130.1">
        <property type="nucleotide sequence ID" value="XM_038206202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206202.1">
        <property type="protein sequence ID" value="XP_038062130.1"/>
        <property type="gene ID" value="LOC119732619"/>
    </dbReference>
    <dbReference type="GeneID" id="119732619"/>
    <dbReference type="CTD" id="6208"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16184" checksum="F30BE37971818817" modified="2023-02-22" version="1">MAPRKGKVQKEEVQVHLGPQVPEGENVFGVAHIFASFNDTFVHVTDLSGRETISRVTGGMKVKADRDEASPYAAMLAAQDVAARCKELGITALHIKLRATGGNKTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEZ3</accession>
    <name>A0A914AEZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062535.1">
        <property type="nucleotide sequence ID" value="XM_038206607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206607.1">
        <property type="protein sequence ID" value="XP_038062535.1"/>
        <property type="gene ID" value="LOC119733026"/>
    </dbReference>
    <dbReference type="GeneID" id="119733026"/>
    <dbReference type="OMA" id="YCATERI"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="364"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="672" mass="77076" checksum="4D18E2EF3E3495B6" modified="2023-02-22" version="1">MELTAATSAVRQDDLLKRELTVNIDQTVFWTDSQTVLKYIMNETTRFPVFVANRIAVIRDGSDISQWRYVPTKLNPADHASRGLSAEELINKPEWLGGPNFLSQPEESWPGAEQIQMEDDEENDNCEVADGASQVNINLVMTSNETSAIDQLIHHYSDWTKLKRAIAWWLRLKTMLQHRKTNCNKKPLQNKPLTVEEMQCAEKAILKYVQGCAFPREVEALKNVKTSDQNPDNPLAAGKEATPIEHQRKPINKGSPLISLDPELRDGLLTVGGRLRHASIPEAAKHQLILPKDHHISTLVIRHLHQRSGHQGRNHILAELRQRYWILKAGVAVRSVIHQCVICRKYQAGPGKQKMADLPAYRVRPDAPPFTYTGVDYFGPFDIKYGRVIRKRYGVVFTCLTSRAIHIEVADSLDTSSCISALRRFMARRGKVKEIHSDNGSNFVGADKELQRAMQEWNHGEINNFALQHDIKWQFNTPAASHHGGVWERQIRTIRKILHAILSEQYMKTCQSEEQLRTFMCEVEAVINSRPLTRASDDPHDLSVITPNSLILLKPDSTLPPGVFSQEDQYSRRRWRQMQYMADVFWKRWTREYLPTLQQRQKWSQPSRNIEKGDVVLIVDNSAPRNSWPMGLVQEVFMDKRGHVRSVRVKTKTSVLVRPITKLCLLLEQDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF50</accession>
    <name>A0A914AF50_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062372.1">
        <property type="nucleotide sequence ID" value="XM_038206444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF50"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206444.1">
        <property type="protein sequence ID" value="XP_038062372.1"/>
        <property type="gene ID" value="LOC119732841"/>
    </dbReference>
    <dbReference type="GeneID" id="119732841"/>
    <dbReference type="OMA" id="TVEYVEW"/>
    <dbReference type="OrthoDB" id="10062030at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="19474" checksum="AF5110AFAFD16B22" modified="2023-02-22" version="1">MYNPKSDGMIERFNRTLLSMVSLMIDPHKRQRDWDQKVMLATFAYRSTPHESTGETPNMLMLGRELYLPLDLTTRVTAKDGEVSEETDYALQLREDMQLAHERAREVLKCSARRQKKCYDQKTIGAKLKTGEFVWLHNPSKTKGLSPKLQRRWEGPYLILQKLSDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFY2</accession>
    <name>A0A914AFY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062284.1">
        <property type="nucleotide sequence ID" value="XM_038206356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206356.1">
        <property type="protein sequence ID" value="XP_038062284.1"/>
        <property type="gene ID" value="LOC119732712"/>
    </dbReference>
    <dbReference type="GeneID" id="119732712"/>
    <dbReference type="OMA" id="CSDVDTH"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="38949" checksum="5279310F5D075BB5" modified="2023-02-22" version="1">MELPTNTSVSYLNGTLYTHPELIFFSVGFSILIVLAIIGNSLVLVAVARTKKLQNVTNVFVVNLSLTDCLSSFGFLWSVPGMASTTPGYLLESDVPCVAAAGLVFTAEGCSVYTLANIALNRCILITRSKETYQWLYTPKKIALMVLVSWLIPFCGIVVPPLSGVGDLGFDPESRTCSDVDTHPRAAVYDKVQFAVLYPAPLLVIIVSYILIWRHVKRHFRNRRNNTSNLQSLKPLKSDSTPKPDASHTNVSSSQKPGEASPRHSGSSHHLSRMRNEQFAITKNLFVVVFAFVVCFTPIFTMVVTKSNRYHLYGALFLFASGCINPIIYAAKHPHFRPVLRSMVRCRCSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AII9</accession>
    <name>A0A914AII9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063800.1">
        <property type="nucleotide sequence ID" value="XM_038207872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AII9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207872.1">
        <property type="protein sequence ID" value="XP_038063800.1"/>
        <property type="gene ID" value="LOC119734380"/>
    </dbReference>
    <dbReference type="GeneID" id="119734380"/>
    <dbReference type="OMA" id="CDFPVRP"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="186"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="612" mass="69953" checksum="DC69E4B48F310D68" modified="2023-02-22" version="1">MPRKKPFSGKQKKKQIQEKRDRKKPEGSGQRTNAAISHRSRQQSYELNSSEEERGSGSDTECAAGAGIPDVNKLNQQPISNKKQHDPNRFRLHFEKDSRAEVERRKKQSMQPFEILPEEALEVDLGDIYQPGSVLDMPKRPTWNYSLSKEQVEAREEAMFQEYLHNIFSKYSSRQLSYFEINLETWRQLWRVLEMSDIVLLITDIRHPALHFSPALYDYVTKELRRHLILVLNKIDLAPPSLVVAWLAYMKERFPDVHVVRFTSFPRENLTPNSIDPGKVLHRKRRKGAYTAVGPMQLLKACQTVCQGRVDLSSWSEKIEAELRGEEGLAAKIIESTEAETVPDTSFSEHTFFRDGVLTIGCVGHPNVGKSSLMNGLCGRKVVSASRTPGHTKHFQTIFLTPTVKLCDSPGLVFPSLVDRQLQILSGMFPVAQVQEPYTAVGYLAQRVNLIPILKIKHPLYGSKPKEGETEEWSAWDICEAWAEKRGFMTSKAARHDVYRAANNLLRLAVEGRLCLCMRPPGYTNQKEQWEQHPETLEISKIQEQHKQLNPEEIDQSEFTSSGGEESDADIESNEVERDTDTRRRRRRKAREDSEGDRLVATSNKFALLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ11</accession>
    <name>A0A914AJ11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063541.1">
        <property type="nucleotide sequence ID" value="XM_038207613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207613.1">
        <property type="protein sequence ID" value="XP_038063541.1"/>
        <property type="gene ID" value="LOC119734239"/>
    </dbReference>
    <dbReference type="GeneID" id="119734239"/>
    <dbReference type="OMA" id="DARIGYM"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006128">
        <property type="entry name" value="PRK08272.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35259" checksum="191F90686FC3663B" modified="2023-02-22" version="1">MAMSKICRLSKGFLCHSSLNSIQRSLTSSSRMAREFQSIKYSTRDKVAYITLNRPQALNAIDEHMPCELEKAVQLANDDDDTRVIVLSGSGRSFCSGYDLKKFAEEGRGTMIGSQKMPWDPYTDYRMMHAATEKYMSLWRSLKPTVCKVHGFAIAGGSDIALCCDLVVMAEDAFIGYPPSRVWGCPTTAMWAYRVGAERAKRLLLTGDVISGTEAARIGLVGQAVPSDKLDEEVDRLVQRMVTVPTNQLFFQKQVINQVVEQMGLSATQRLATLFDGMSRHTPEGVAFQNRSAEVGFKQAVKERDEGTTDWSPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ43</accession>
    <name>A0A914AJ43_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UQCC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063576.1">
        <property type="nucleotide sequence ID" value="XM_038207648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207648.1">
        <property type="protein sequence ID" value="XP_038063576.1"/>
        <property type="gene ID" value="LOC119734260"/>
    </dbReference>
    <dbReference type="GeneID" id="119734260"/>
    <dbReference type="OMA" id="KGSHRTW"/>
    <dbReference type="OrthoDB" id="5783753at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029160">
        <property type="entry name" value="UQCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023248">
        <property type="entry name" value="UQCC4_vert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268">
        <property type="entry name" value="PROTEIN CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35268:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15013">
        <property type="entry name" value="CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02042">
        <property type="entry name" value="CCSMST1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="160" mass="18634" checksum="7C0B4260B6D95814" modified="2023-02-22" version="1">MTFVNCSRVLKVMNLARSWPSRSGMTAVQRRPILPPSCQHRCASSQQTRSKTSSKRTDDQDEDNEDEPLPYLNSKARDWSVHNSYGRHKKRPWYKVAPLSIGLAVFMAWVFLRKETEIDRQLEVQLHERLPNLFEDPSKKNVGKDPILVPESEEEEKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKD7</accession>
    <name>A0A914AKD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD finger-like domain-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048789.1">
        <property type="nucleotide sequence ID" value="XM_038192861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064197.1">
        <property type="nucleotide sequence ID" value="XM_038208269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192861.1">
        <property type="protein sequence ID" value="XP_038048789.1"/>
        <property type="gene ID" value="LOC119722638"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208269.1">
        <property type="protein sequence ID" value="XP_038064197.1"/>
        <property type="gene ID" value="LOC119734730"/>
    </dbReference>
    <dbReference type="GeneID" id="119722638"/>
    <dbReference type="GeneID" id="119734730"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12417" checksum="97F0319DE22C7BA2" modified="2023-02-22" version="1">MAKHHPDLIFCRKQAGVAIGRLCEKDDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL24</accession>
    <name>A0A914AL24_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064278.1">
        <property type="nucleotide sequence ID" value="XM_038208350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL24"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208350.1">
        <property type="protein sequence ID" value="XP_038064278.1"/>
        <property type="gene ID" value="LOC119734792"/>
    </dbReference>
    <dbReference type="GeneID" id="119734792"/>
    <dbReference type="OMA" id="QESKTHR"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01756">
        <property type="entry name" value="PLAT_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="4">
        <location>
            <begin position="508"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134222" checksum="2A5168BFD40DB2F3" modified="2023-02-22" version="1">MSSQDVIKSTAKKLKYYMEVKRMEDAFDLSGPDKPQRHYPTLKPRPTLLYDGLHDRALKHYFRNAEVKKHLAQMKPRTSQSERESKVRRDVDRYMDKSHFTSPYTNLVRATPPPKKRRSNFRGGPLLLRSRHGPQLSRGETERLVNAATKLLVATETIPIDQQRNGRWHSGKNFRVDSGVGSSLPMIDNGYEDYGHRPSRPERPKSTYGHRPTRPKSSYGERPRPKSAMEARPKSAAKSSPSTARYGYDSMGRKIKLHLEQPRHYEASESDQDPDDYDDDEFEDSMDNSMNILVPVKGSGKNQSPEWLNIQMSKVDMNNHNDYEVDDEEEEEEEDERGDTLSQGDDILHSIDNTTQTGREMSCQTVEDKDNTKDTQTRRANTEESMTDPYQADMAIQTAPPPITLGTQTVVPPPEVSTQTVPAQPTISTQTYPEVYCQTTPIMNMETQTEVHQPEVACQVEPPNEMGVQVDPPPPPPSPPPPPEPEPEPEEDYEFLKHGPRLKSGKRTIYELSIHTGNRLGASTRADVHVTLYGEKGNTGKIKLKQSKDTKDGKKVKFQKGQIDVFKVESYYVGKIECMCIGHDKTELGCGWFLDKVLIREYGDDVTYEFLCERWLSAQDEDGQTVRTMPVTNIIMDVSSSSQSEADHSDYAEKSPDSSTYTDTDLRLHQVTASDGHFVPTGPQPRRPPSRHTDRTDHSDASSRVGRKHKRKKSSKKGKGKGKSRRKPRTPVTTTGTDDTDSDTESDSERSSRSDSDSGDDDDGSDSGSGSSGSGSSSGSGSGSGSSSGSDSSSNDRKADGESKSGSIGSGRYRDRSGKAPKEENTVHFPNEDTDAAPSEKDNRTARDVDSSHEEDDDDRSSRGSVSQSDSVSKKSVTSEKTETKDVPKPKGPSDEGSTKPKDKDNSDYMTGFKAALKMKEHQHEQEEAARLADEEKQRQEEESLLNGPSVHQSCKKGDLDRVRKLVQHNAELINTPDERGWTPLHIASANGRLALVKYLAANDVNINDLTPTGYTAMHMAAMNGHVAVVKVLTAMGMTVDCRTVDEQTPLHMAAMSGHLECTKWLVANNAPLDVIDNMGRTAYDLAEEYQHNEVVTFLTSCQRELKSQDSSLAMLRSRSPSMGSQNRRSLSASDSEKDTDKDGQQSSDEEDKPDSVAAKQKEEQKHAVLERKKSFKDQQERMSSSGKSFLDSIRAEYSDDEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALQ8</accession>
    <name>A0A914ALQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064682.1">
        <property type="nucleotide sequence ID" value="XM_038208754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208754.1">
        <property type="protein sequence ID" value="XP_038064682.1"/>
        <property type="gene ID" value="LOC119735059"/>
    </dbReference>
    <dbReference type="GeneID" id="119735059"/>
    <dbReference type="OMA" id="IHQMTHG"/>
    <dbReference type="OrthoDB" id="8734935at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF13">
        <property type="entry name" value="FATTY ACID DESATURASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="41449" checksum="0A52EA90E52C0878" modified="2023-02-22" version="1">MSPTGLVFLRLIASARIEVSRMERKSMKETNGNIVCDALNGASMSELSNAVQKVQSKSSWWEMYGVDWCIIASGFALVPPGLLLIGYPTWPAFIAGILLLGLFYGMLKTKMSHLAVHSALCHSKIASRFWEVFFVEFLGSFSVEFAKTSHIKVHHPHTNIIGLGDSSTWRAPFLPCLIYMFVAPLLLPAFIPFLAVGFLVRDNKLNRALQCAVVVTLGLIANISLLVYVSGLSLKSAVLSLLSYRAVMELPYIHINIFQHIGLPMYLPENRPPRLYMMSSGVLNLSHNPLLSWNFGHSLIGCHVEHHLFPKLSDNMCLKIQPIVKKYLQDHKLPYHERGYFNRLQHFVKEYQALMVNLPPITEFIGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANQ0</accession>
    <name>A0A914ANQ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065655.1">
        <property type="nucleotide sequence ID" value="XM_038209727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANQ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209727.1">
        <property type="protein sequence ID" value="XP_038065655.1"/>
        <property type="gene ID" value="LOC119735793"/>
    </dbReference>
    <dbReference type="GeneID" id="119735793"/>
    <dbReference type="CTD" id="56006"/>
    <dbReference type="OMA" id="SEYYPHL"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57500" checksum="B066DF40BC0CFAE5" modified="2023-02-22" version="1">MSSKGGTGPVGGASGGGHNGGGRRRRRRVRSKTQEESRDDFSSPQLSKPTIILAKSSASQSQGKQELYGSSPEPGGATPSTHQAGEAPKSTPQFKIITRQSESTPSRPIPTVAAGSAASTANQALYQSPATVALYGSSPMTEAGQSGGSGSHHNQPQVVSQSTRPLAPSGTAHSITIEVPVHNRLTAPPEMKQSVRLVDNSFQWCDNGMEMMLDHTDFLVVGVLGLQGSGKSTLMSMLAGNKPSDQQGSYIFKPQTKENRNQSLHQTMGIDLFVTGERVLVLDAQPVLSSSVMDHLLSHEKSLPPDMTSAEICNEIQSLQLAAFLFTVCHVVLVVQDWFLDMNLIEFIKRAEMLKPPTPNPAMEGANNEDTEDFFPNLVFVLNKARQEDFQLTAVQSMHQTIDRLFKDSKLTYQGTASLTHTKLMPGLNPKNLPLDVNLFVLPCLDTAASEHSSTDDQSILLSLLPVSYQGHPSVDLLVKSFRNQIYGAARSSLTHTSLTEKNWFHYAGRTWETIKKSSLMSEFNRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APD7</accession>
    <name>A0A914APD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDB1- and CUL4-associated factor 8-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065478.1">
        <property type="nucleotide sequence ID" value="XM_038209550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209550.1">
        <property type="protein sequence ID" value="XP_038065478.1"/>
        <property type="gene ID" value="LOC119735695"/>
    </dbReference>
    <dbReference type="GeneID" id="119735695"/>
    <dbReference type="OMA" id="KGHRNND"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79945" checksum="E9D779A6712A3E1E" modified="2023-02-22" version="1">MADEDMDMDNDKEVSNHMDTDDKGLNHGNDRTAESELTENAAKRAGQGDKPGRKDAEEVGENCTENSVIPSGDGAKHTEGGGSKDGIIPDAKNATKSEDVHVDKMATGDSSERAEGEGVEDETAKGEKQSSTEDGTAADKAGKSTEGGDAEERMTTDDPNNAATKSPGKSLKLFSKDRKSRPSRRSYRLRNLEAGDGEQSDSSDEDERHDTDSGTRSQRSHSDSSETESDMEREVNEEHDEDGEEDPENKTGGTELCSDLEDELLAKLLPKPTWRALPMLRSREIGSRKEQLSFCSKSIGSVHMVSRFEKYCELKHHDGCVNTLHFNQSGQLLASGSDDLNIVLWDWARQKTTLVYPSGHRSNVFQAKFMPFSGDTTIVSCARDGQVRVGELSSTGICKGTKKLVQHKEAAHKLGLEPDSPVVFLTCGEDAVVYNIDLRTAKANKLLTVKEEVRKIPLYTIFLNPMNTHEFCVGGRDHFVRIYDRRKLSPESESPVKKFCPHHLMSSETRANVTCCVYSYNGREILASYNDEDIYLFDSTHSDGAEFIHCYKGHRNNQTVKGVNFYGPQSQFVVSGSDCGNIFLWEKTTERIVQYMRGDVQGVVNCLESHPSSAVLATSGLDHDVKIWMPTAKEPSLLEGLKRTMYSNRREREEEKSREPDMIDGHMLMFLMHHLRRRARRQAREAGEMDSDSSSSDSDSSDDEDGDGGPPHERSQCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQS9</accession>
    <name>A0A914AQS9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065761.1">
        <property type="nucleotide sequence ID" value="XM_038209833.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209833.1">
        <property type="protein sequence ID" value="XP_038065761.1"/>
        <property type="gene ID" value="LOC119735889"/>
    </dbReference>
    <dbReference type="GeneID" id="119735889"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16768" checksum="2981915F3AA1508E" modified="2023-02-22" version="1">MADKKGKPSANGSAKPSAKGPSNDQIVAKFNQLRQEQRALMSKIAELEGDQNEHRLVIETLKEADADRKCFRLVGGVLVERTVGEVAPALQHNKDQLAKLCEALTKQVEAKGKEINEYREKHNIRVKGEQXPSQAQEAKDKANTQGVLVTSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASF2</accession>
    <name>A0A914ASF2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066593.1">
        <property type="nucleotide sequence ID" value="XM_038210665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210665.1">
        <property type="protein sequence ID" value="XP_038066593.1"/>
        <property type="gene ID" value="LOC119736649"/>
    </dbReference>
    <dbReference type="GeneID" id="119736649"/>
    <dbReference type="OMA" id="NESMRSE"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="17964" checksum="A41DEBA4753CF3F4" modified="2023-02-22" version="1">MRTSASRQDRVCQKGPSRRLTDDRPRRRRVSPHQDVLLEPSYQVYPQQKFGEFRGTISDILEQMIPETLARMPYDARVCSRQAKALAGDIQERVKDLGIERYKLITVVHIGEIQQQSIRVCSRGIWDVEVDSSVTYQYQNASLYCVATIFGIYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATL1</accession>
    <name>A0A914ATL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067112.1">
        <property type="nucleotide sequence ID" value="XM_038211184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067115.1">
        <property type="nucleotide sequence ID" value="XM_038211187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211184.1">
        <property type="protein sequence ID" value="XP_038067112.1"/>
        <property type="gene ID" value="LOC119737094"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211187.1">
        <property type="protein sequence ID" value="XP_038067115.1"/>
        <property type="gene ID" value="LOC119737096"/>
    </dbReference>
    <dbReference type="GeneID" id="119737094"/>
    <dbReference type="GeneID" id="119737096"/>
    <dbReference type="OMA" id="MASEPCG"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="513" mass="57544" checksum="91698E0656F6D82D" modified="2023-02-22" version="1">MATDWLFVLAVYIFPPAAVCLLFLLIFLLVKYYRQTLRMKSYNEFLVLTQIRALYKEFIFESVDRSQLLSPAAIKKRSRIASQRRKRTARPSAIVLNENVSIVPDDLKIRFDQLSMGKVLGQGAFGRVYQAVLKDSSPSGTQSTVAVKTVQDTSDPYQIIKFLEEGLIMKTFDHPNVLGLLGLTFDPKEQPLIVIPFMANGDLKTFLTKQKQRVSNSQLIQFAYHVALGMEYLGRQRFVHRDLAARNCMVDDKLVAKIADFGLSRDLDESNYYTSGDKQAKLPIKWMAPESMERMKYSSKTDVWSYGVLLWEIFSRGKKPYPNINNKDIYPYLKEGGRMSPPKFCPTKISKIMQDCWKDSSKMRCTFGQIVEKLEDLIASEPGSFSSSSVPPICPRRPPRARVERAGRDADAEAGSEDDQKINDQTTELKHTYVNFGPRSISEGYGRALAAKTLGKACQEVGIGESTDRGSNLIPMETMESGEEGNMESNVAGDVEAGGNKDVKGGIANDGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU36</accession>
    <name>A0A914AU36_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067574.1">
        <property type="nucleotide sequence ID" value="XM_038211646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067575.1">
        <property type="nucleotide sequence ID" value="XM_038211647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067576.1">
        <property type="nucleotide sequence ID" value="XM_038211648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067578.1">
        <property type="nucleotide sequence ID" value="XM_038211650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU36"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211646.1">
        <property type="protein sequence ID" value="XP_038067574.1"/>
        <property type="gene ID" value="LOC119737354"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211647.1">
        <property type="protein sequence ID" value="XP_038067575.1"/>
        <property type="gene ID" value="LOC119737354"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211648.1">
        <property type="protein sequence ID" value="XP_038067576.1"/>
        <property type="gene ID" value="LOC119737354"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211650.1">
        <property type="protein sequence ID" value="XP_038067578.1"/>
        <property type="gene ID" value="LOC119737354"/>
    </dbReference>
    <dbReference type="GeneID" id="119737354"/>
    <dbReference type="OMA" id="KWHLLAN"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="526"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="762" mass="84949" checksum="F1A189D513D60035" modified="2023-02-22" version="1">MAAFEEFPDPDVILPRKRRSITINRPAFTELDFQEIHKENVKETKSLRTRFTKFLGKHKCSTKSAKACFFTLFPIFVWLPAYDVKRDLLGDFASGLTVGIMRLPQGMAYGLLATLAPVYGLYTVFFPALLYAMMGTSRHLSVGSFAVVSIMTAAAVDRVVEETRPAEGPYNEGLERAKIAASLAFLVGIFQLGLGVLRLGFVSTYLAEPLVRGFTTGAAFHVFNSQFKYLFGIEVTRYNGPFAIYKTFFFLFANLALTNVTELIIALVNLVALVTVKELQDKYKEKIKYPIPLELLAIILTTMVSHFASLEKKYGANVVGDIPTGLPTPELPSFSHMDSLITDAIIISIVTFSVSVSMGYIFAKRNNYEIDANQELVALGSMSVFGCFFVCYPAASSLSRSLLQEISGGKTQLASLFSCIFILFVLLFMGPLFYSLPKSCLAAIVVVALRGMFRQFRDIKVLWKYSKIDCMIWVVTWFSTMSLGVDYGLGVGVVFAIMTVIIRTQKPYCCLMGRIPGTDIYRDLSYYQSAKQIPGVMIFRMHSPLYYANADYVKASLYSKSQLNPVKILMARAKVESKKRKAERRTEKAEVRRRKKAGKKHTRLDEEEMSAMNVSDTTNHHLREDAIEVIDDNRNSNNRLGNGDHLSLEMAAEDKTHSLVLDLGSVSFLDTVGISALKSIIADYEKIGITVVMAHCKENVREMLLGSGFMEQVGLDRMFVTLHDAILQTANDQDVEDMREQNAWEHIPGGGGGDAACEIMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU65</accession>
    <name>A0A914AU65_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067218.1">
        <property type="nucleotide sequence ID" value="XM_038211290.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211290.1">
        <property type="protein sequence ID" value="XP_038067218.1"/>
        <property type="gene ID" value="LOC119737167"/>
    </dbReference>
    <dbReference type="GeneID" id="119737167"/>
    <dbReference type="OMA" id="FGFNCTC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061326">
        <property type="term" value="P:renal tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="107"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000459">
        <property type="entry name" value="Axotactin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000185">
        <property type="entry name" value="basement membrane-specific heparan sulfate proteoglycan core protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000080">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000100">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000537">
        <property type="entry name" value="Notch 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="168"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="128"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="169"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="165"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="72"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="95"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="168"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="153"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="169"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915451" evidence="20">
        <location>
            <begin position="23"/>
            <end position="6821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6784"/>
            <end position="6807"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="23">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="571"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="609"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="649"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="689"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="729"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="767"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="805"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="843"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="881"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="919"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="957"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="995"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1033"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1071"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1111"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1150"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1188"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1228"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1266"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1306"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1346"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1384"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1422"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1460"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1498"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1536"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1574"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1612"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1650"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1691"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1729"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1767"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1805"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1843"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1881"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1921"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1959"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1997"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2036"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2074"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2112"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2150"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2188"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2226"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2264"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2302"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2340"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2378"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2416"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2454"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2492"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2530"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2568"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2606"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2644"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2682"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2720"/>
            <end position="2756"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2758"/>
            <end position="2794"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2796"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2834"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2872"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2910"/>
            <end position="2946"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2948"/>
            <end position="2984"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="2986"/>
            <end position="3022"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3024"/>
            <end position="3060"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3062"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3100"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3138"/>
            <end position="3174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3176"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3214"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3252"/>
            <end position="3288"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3290"/>
            <end position="3326"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3328"/>
            <end position="3364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3366"/>
            <end position="3402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3404"/>
            <end position="3440"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3442"/>
            <end position="3478"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3480"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3518"/>
            <end position="3554"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3556"/>
            <end position="3592"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3594"/>
            <end position="3630"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3632"/>
            <end position="3668"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3670"/>
            <end position="3706"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3708"/>
            <end position="3744"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3746"/>
            <end position="3782"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3784"/>
            <end position="3820"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3822"/>
            <end position="3858"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3860"/>
            <end position="3896"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3898"/>
            <end position="3934"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3936"/>
            <end position="3972"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3974"/>
            <end position="4010"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4012"/>
            <end position="4048"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4050"/>
            <end position="4086"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4088"/>
            <end position="4124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4126"/>
            <end position="4162"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4164"/>
            <end position="4200"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4202"/>
            <end position="4238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4240"/>
            <end position="4276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4278"/>
            <end position="4314"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4316"/>
            <end position="4352"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4354"/>
            <end position="4390"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4392"/>
            <end position="4428"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4430"/>
            <end position="4466"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4468"/>
            <end position="4504"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4506"/>
            <end position="4542"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4544"/>
            <end position="4582"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4584"/>
            <end position="4620"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4622"/>
            <end position="4658"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4661"/>
            <end position="4698"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4700"/>
            <end position="4736"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4737"/>
            <end position="4773"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4776"/>
            <end position="4812"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4813"/>
            <end position="4849"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4852"/>
            <end position="4888"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4889"/>
            <end position="4925"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4928"/>
            <end position="4964"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4966"/>
            <end position="5002"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5003"/>
            <end position="5039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5042"/>
            <end position="5078"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5079"/>
            <end position="5115"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5118"/>
            <end position="5154"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5155"/>
            <end position="5191"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5194"/>
            <end position="5230"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5231"/>
            <end position="5267"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5270"/>
            <end position="5306"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5307"/>
            <end position="5343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5346"/>
            <end position="5382"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5383"/>
            <end position="5419"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5422"/>
            <end position="5458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5459"/>
            <end position="5495"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5498"/>
            <end position="5534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5535"/>
            <end position="5571"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5574"/>
            <end position="5610"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5611"/>
            <end position="5647"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5650"/>
            <end position="5686"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5687"/>
            <end position="5723"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5726"/>
            <end position="5762"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5763"/>
            <end position="5799"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5802"/>
            <end position="5838"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5839"/>
            <end position="5875"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5878"/>
            <end position="5914"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5915"/>
            <end position="5951"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5953"/>
            <end position="5989"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="5991"/>
            <end position="6027"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6029"/>
            <end position="6065"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6067"/>
            <end position="6103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6105"/>
            <end position="6141"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6143"/>
            <end position="6179"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6181"/>
            <end position="6217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6218"/>
            <end position="6253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6255"/>
            <end position="6291"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6293"/>
            <end position="6329"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="21">
        <location>
            <begin position="6334"/>
            <end position="6447"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6449"/>
            <end position="6488"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6494"/>
            <end position="6530"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6533"/>
            <end position="6570"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6572"/>
            <end position="6608"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6611"/>
            <end position="6648"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6649"/>
            <end position="6686"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6688"/>
            <end position="6724"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="6726"/>
            <end position="6762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1197"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1216"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1275"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1315"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1524"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1562"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1600"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1638"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1679"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1717"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1755"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1793"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1831"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1869"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1890"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1909"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1947"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1985"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2024"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2062"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2100"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2138"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2176"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2252"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2290"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2328"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2366"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2404"/>
            <end position="2413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2442"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2480"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2518"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2556"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2594"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2632"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2670"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2708"/>
            <end position="2717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2746"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2784"/>
            <end position="2793"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2822"/>
            <end position="2831"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2860"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2898"/>
            <end position="2907"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2936"/>
            <end position="2945"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2974"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3012"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3050"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3088"/>
            <end position="3097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3126"/>
            <end position="3135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3164"/>
            <end position="3173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3202"/>
            <end position="3211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3240"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3278"/>
            <end position="3287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3316"/>
            <end position="3325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3354"/>
            <end position="3363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3392"/>
            <end position="3401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3430"/>
            <end position="3439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3468"/>
            <end position="3477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3506"/>
            <end position="3515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3544"/>
            <end position="3553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3582"/>
            <end position="3591"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3620"/>
            <end position="3629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3658"/>
            <end position="3667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3696"/>
            <end position="3705"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3734"/>
            <end position="3743"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3772"/>
            <end position="3781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3810"/>
            <end position="3819"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3848"/>
            <end position="3857"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3886"/>
            <end position="3895"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3924"/>
            <end position="3933"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="3962"/>
            <end position="3971"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4000"/>
            <end position="4009"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4038"/>
            <end position="4047"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4076"/>
            <end position="4085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4114"/>
            <end position="4123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4152"/>
            <end position="4161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4190"/>
            <end position="4199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4228"/>
            <end position="4237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4266"/>
            <end position="4275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4304"/>
            <end position="4313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4342"/>
            <end position="4351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4380"/>
            <end position="4389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4418"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4456"/>
            <end position="4465"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4494"/>
            <end position="4503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4532"/>
            <end position="4541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4553"/>
            <end position="4570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4572"/>
            <end position="4581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4610"/>
            <end position="4619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4648"/>
            <end position="4657"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4688"/>
            <end position="4697"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4726"/>
            <end position="4735"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4763"/>
            <end position="4772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4802"/>
            <end position="4811"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4839"/>
            <end position="4848"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4878"/>
            <end position="4887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4915"/>
            <end position="4924"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4954"/>
            <end position="4963"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="4992"/>
            <end position="5001"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5029"/>
            <end position="5038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5068"/>
            <end position="5077"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5105"/>
            <end position="5114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5144"/>
            <end position="5153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5181"/>
            <end position="5190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5220"/>
            <end position="5229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5257"/>
            <end position="5266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5296"/>
            <end position="5305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5333"/>
            <end position="5342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5372"/>
            <end position="5381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5409"/>
            <end position="5418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5448"/>
            <end position="5457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5485"/>
            <end position="5494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5524"/>
            <end position="5533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5561"/>
            <end position="5570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5600"/>
            <end position="5609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5637"/>
            <end position="5646"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5676"/>
            <end position="5685"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5713"/>
            <end position="5722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5752"/>
            <end position="5761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5789"/>
            <end position="5798"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5828"/>
            <end position="5837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5865"/>
            <end position="5874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5904"/>
            <end position="5913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5941"/>
            <end position="5950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="5979"/>
            <end position="5988"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6017"/>
            <end position="6026"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6055"/>
            <end position="6064"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6093"/>
            <end position="6102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6131"/>
            <end position="6140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6169"/>
            <end position="6178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6207"/>
            <end position="6216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6222"/>
            <end position="6232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6243"/>
            <end position="6252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6281"/>
            <end position="6290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6319"/>
            <end position="6328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6478"/>
            <end position="6487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6520"/>
            <end position="6529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6560"/>
            <end position="6569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6598"/>
            <end position="6607"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6638"/>
            <end position="6647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6676"/>
            <end position="6685"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6692"/>
            <end position="6702"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6714"/>
            <end position="6723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="6752"/>
            <end position="6761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="6821" mass="720944" checksum="4A81500AE11936CE" modified="2023-02-22" version="1">[encoded data, 6821 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVX6</accession>
    <name>A0A914AVX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc transporter ZIP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 39 member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Zrt- and Irt-like protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29352"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067912.1">
        <property type="nucleotide sequence ID" value="XM_038211984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067913.1">
        <property type="nucleotide sequence ID" value="XM_038211985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211984.1">
        <property type="protein sequence ID" value="XP_038067912.1"/>
        <property type="gene ID" value="LOC119737546"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211985.1">
        <property type="protein sequence ID" value="XP_038067913.1"/>
        <property type="gene ID" value="LOC119737546"/>
    </dbReference>
    <dbReference type="GeneID" id="119737546"/>
    <dbReference type="CTD" id="29985"/>
    <dbReference type="OMA" id="HHHGHFN"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF221">
        <property type="entry name" value="ZINC TRANSPORTER ZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="43474" checksum="138B32ADFDB38B25" modified="2023-02-22" version="1">MEDILTKGTGPSSRTDNFVTKKSGEPTYGSSMSILLLQLTCMIAVFLITLAGALLPLKVIGTKASQSIKRRQRSEKILSYCNCLAGGVFLATCFLGLIPAARDKFQEIFREKNITTEYPFCEAVVVLGFFLILSLEQLALSLQQQWQNRGKADEIQMKKVSLKFNAKDGKVKVDTTDLEDEEEDEDLFNRDSDTQPMLGPAKGITEERNGGYRRDNVSRLDETNDLEAGSHSHNAGSHGHSHLSNINNSGLLRSLILLFALSTHSIFEGMALGLQEDIKRIVYLLIAMLAHESLAAFALGASLIKNSVSTYAFVIYGVLFAGMIPSGIALGLWIRASPGFGAVVCSAVMQAIAAGIFIFVTFFEILNHEFEVHRDRPQKIAFAVLGYVILAALEAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW03</accession>
    <name>A0A914AW03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067431.1">
        <property type="nucleotide sequence ID" value="XM_038211503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211503.1">
        <property type="protein sequence ID" value="XP_038067431.1"/>
        <property type="gene ID" value="LOC119737288"/>
    </dbReference>
    <dbReference type="GeneID" id="119737288"/>
    <dbReference type="OMA" id="LYEDRTH"/>
    <dbReference type="OrthoDB" id="124789at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049218">
        <property type="entry name" value="DUF5575_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20784">
        <property type="entry name" value="DUF5575_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="891" mass="102753" checksum="DC1087728EAED1CA" modified="2023-02-22" version="1">MHVKAASPRGGAVQLQVPKGEMASRSKAANPCPMEETSHVRIPTSSKPQVGMKFNSYLEVERFIREHEEANYVKFKKLDCRTVECSRKRAPKRYLSDKLQYATVTLSCIHQGQFKSKSTKLQPKLETQRMGCQAKFRFSATPSGMQLYLADFITQHNHPHDEASYRGLPQKRKVNDQEREESFKLLQKRKRGSAQTEENLHAMEETLSDHIPNSSKPQVGMKFSSYDEVERFIQEHEEANYVKFRKLDCRTVESNRKRMPKRYLSDELRYATVTFSCIHHGQYASQSRVRHRQKSRRIGCQAKFRFAATPSGKQLYLADFVTQHNHPHDEASFRSLPQKRKLNDQEREEAFKILQKKGRRATLKHLQEATGKAVTTRDVHNLAAASRQNSLCYTNIKAILDYLSQVEEQTSVIEVVTNADERVVGIYYQDREMIRVYASFPHYLVVDATCKNNSLQMPLYVILVEDSNCEYEIVALFFLIASNEESFRAMMRRFKENNPIWPCLQVIMADKDNSTKILVDEFPCASLQMCLSQVLRKFKQDTSKKQLGLQKEEEAFCEKLMRKLAASKSEAVYMEIYKQLLNTELQTVIKYYNTTWHNNRQEWVEGLKSRSVTLKKEDPEKLKAVSEKLVAVFKNSPTSKKVMTNLKREVESLREERDKTAAALLAENAPITNPDNTTVSKFQQYLTPCALKYVLRQLKLSWKVKVKADIDNKSMTITSSKDNMIVCVDSCPCRLWQSLCLPCSHIFAVRRTKGLPFFAKAVIGSRWSLEYYRSCSRLSAQNTDTAQSIDALQRQRLRLLSRHEKYIRVSKITKQLATVMSEAPAEQFASQLEAVQKVLTCFQNGSSVNIMEEVGQHAIDTEVITESFPYQEDVRMESLQETHTQDEQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW43</accession>
    <name>A0A914AW43_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STRIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068315.1">
        <property type="nucleotide sequence ID" value="XM_038212387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212387.1">
        <property type="protein sequence ID" value="XP_038068315.1"/>
        <property type="gene ID" value="LOC119737784"/>
    </dbReference>
    <dbReference type="GeneID" id="119737784"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="430"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="93540" checksum="B7CED0394316C41A" modified="2023-02-22" version="1">MCNLMVFSLKIPAVMEVQMAGGLAAKRGGGLPKLRELLRRQRRDSDSQNDSPDLEFEYDDANKYTQEIAELYSYTEEPEFALCQKCFEEDFHSYIKEKWTQLSPDRQRMHILRLLNSVESAKREQRMKSARAVLYLAQGCFSECSSEEEQVKRARENCFLLYECSVFNTFVELLSMEAENSVAASTALRKPAVSIVDSTDLRIVLSVLYIMIETLRMDSDQDSDKQKHQREIFKTELGQPVCGEDSLAIVLFNMVTKFCSGHAPHFPIKKILLLLWKTLLFSLGGINEYKLMKQQARKAADLDAVKEDTIQVTKTMRASSPPASSGDGLQERRTRGSLRRGLVKQNGIDEPMPEDPDRREEESKEEQLNGGSEEEEENSSQPPPTPREHKALPWTPKVRQKDLDVFLDHTRRKFVGFQVQSDSDTLAGLPQPIHEGVHVLKKHVYVSLAEIQIKQEEQINKNPISKGEENIPATATELLYQAVLPNLPQYMISLLKILLAAAPTSKAKTDSINILADVLPEEMPITVLQSMKLGVDVNRHKEVIVKSISALLLLLLKHFKLNHVYQFEFMSQHLVFANCIPLVLKFFNQNIMAYISTKNSINVIDFPLCVIGDQPELTAESLEAGDTIPYCWRNLFSCINLLRILNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQVYVLKLLKVQTKYLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDMDARPWDFQAEECALRACVDRFNTRRYDQCTPKDPEYQPVDNNPQSVLSQKMELSEEFQRFYEVWLDREVFTTQINWDLLLKDKICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWS9</accession>
    <name>A0A914AWS9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068153.1">
        <property type="nucleotide sequence ID" value="XM_038212225.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212225.1">
        <property type="protein sequence ID" value="XP_038068153.1"/>
        <property type="gene ID" value="LOC119737688"/>
    </dbReference>
    <dbReference type="GeneID" id="119737688"/>
    <dbReference type="OMA" id="CELPWWF"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000022">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037632901" evidence="17">
        <location>
            <begin position="25"/>
            <end position="3084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2002"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2213"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2252"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2376"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2412"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2507"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2763"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2802"/>
            <end position="2820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2851"/>
            <end position="2871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2891"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2953"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="20">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="18">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="18">
        <location>
            <begin position="549"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="18">
        <location>
            <begin position="768"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="19">
        <location>
            <begin position="2047"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1471"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3011"/>
            <end position="3037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2611"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1478"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3016"/>
            <end position="3037"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2615"/>
            <end position="2628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3084" mass="344755" checksum="EF8E700CDCB73FBD" modified="2023-02-22" version="1">MMWDETLLPCLLLIWFLTGSFVGAATLDGCYSIDRTSNAFTISPGRYDPSSLDHAACIEACAYQEYSYASLRAGQFCMCSDTNYLPAAKKADNSLCNTPCTGDNLITCGHDNYALVYHITDTRALIQLDDAVTYVVGTSASVSPSSVSGSDLEYSYDFGDGTAATNSSDHTYTAPGEYSVVVTVHNDKWVDFDAFAHSVNTQLSGVAVTCPEGAGVAQDFECTVEILHGNDLYVTPTFGSGAEAVTGPVLPAGSPTYSHIGHVSQYPDPSLPSNDVHGAATLIFWVFPGSEVQQASKLVAIEAAIASVGDGTLHFVIYKPVCTSPSDVFCPIENSCMAASACSYDFTLTTHPTQQDTCTTVLDNYCLYGSRCVDSNDVNTCPAKPTRYEMDPTGNPRAEYEVVEIIARNVASTGYYHDTLATPVDMQMGYVLGVKMRSTGAQISYESTPSGNPVEFQYAGTDYAVGQALPVASKTSGHQIRHLARFTLVQPVEVMITHAFAVPDFYDVTVNVSGSLGGPVEEKTVILIQEIITGLEVEVDTDILRVGGTVTASAKISGGAMVNYTWDWDDGNEDTTIRQATNFNESDVQTHTYITDGTFALTVTAYNFANNETATVTMYVQYPINKDHFMVTSDSPKPHPGDIIFTLTITLPPGEDFGTDPQFSSSITFYENSTETPISIDSDGQSEPFAENVRFSGEYQAIVSINNKISSEYYKLPIVMVEPITGFYVDAMYQPPLPLDGPVKMGFGPTNNVFPLDSPVVFVPRFATGTRMSYNIDYDDGTPLDTVTEETIPYRYTAVGPYLVRVDASNDLPGLASDTVTVILQENIAGIQIMDLQATTANETKEFDISVASLGTTSCLVIDYGDTTQEIFGNQVPCENHADYPGATWVQPLTNSFRTSHIYTSLGSYHMTAFGFNLVSDASTDLFFAVSDLSCNSPQLFIRDGHPDWRGPRVAYFNQDMQIQGITDVKCKSYENMKVWDLQAVDPNTGLAVPGTAVKLTGLPPSHRFYLPDADTAEIYIPPRTIPVGTWKFKYTVHMDQVSDDNIDYVAFANEYVQVRAAALKIQIFEGQTTSKVVGHGSSLKLQPGVLSRDPDLPDDVTDQNFTSIEYFCRRFYEPWELNDQREIDKTKKIVIGGTNTDGVDKGGCFGTGSGLLDYEDDVLDLDTTNTLPNMTYEIMVVVTKGSRVGDAAVQFTVKPGNPPQSSISCSGGTLFEAAYASLVVNPTDDFRLKAGCESGCSGAVYQWEMDYLDENDTLMTVEGWEQHATGVTTESLFIAKDVFTIQPDVHRYLFTIHITNEYDQSGKAHMRVILNEPPEGGFCTITPPEVTTDDKVDITCSDWEDDHGVSKYEFFVQVHGQSVNKVVGFGSLPTAQFYPPLGKAEDDYRVTFGVQIDDVLGATTIRTIGTIIVRPTNISASEFLSEENTVEAEKRFKTLAAEGNSRAINNVILKESSRLNDIRSTGVQALNGTNATAEEDSSDDDVTDPRLYEAGRTKRAYWRKNMADLQTETSLDSLGDVLYSASAATVLTEATDELSHDALSSMTRLGDKMVGTLERTAQDTDQKTVVKTASAMFETFTNMLEGSAKTIEDPLWLLDQYEEDGSSAGFSSLHNDIERELGQSEEESYLTTEDTVSQELKAEKERKARAIVAKTNMLITQVADIMKQNKLPREPASKFQTKTGSMTVSRTEASTAVNQAMKEGKGTFNLPSWCAVRGQADCEEDEIVDVQTNSFQTNHYNYMNSSHRISDKSNVLALKFEDKNGQEIDISNAKEEIEIWIPRPNTETPQCNSFAQNFNTTSQSGMSMHSFYIPFDQTVATLQVIPEEFFSIQYGLLLRYLHPPNREEYDHMWIMPPNISVGANVSDYTIYLNEAYISNNTGTYYLGIVEIPQAPQGDLPDTLFDDNLSPQELLDDILKMHRAFNFTGNYTLCVYISGCAYFNNKTQEWSTDGVRVGPKTTKDLTQCFSRHLTDFASTWLVPPTPLDFQYIFNNAGFLENLTIYITTIVIYVLFVFIFIWARRKDRKDIIMQGLAPMADNKPKHKYLYEIAVMTGQWKGSGTSSKVHFILSGEDDETEVRTFEDDKRPILQTGCVDRFVMAVPKPLGPLNYMRVWHDNSGKGSGQNWFVAYIAVRDLQTRQRYYFIANRWFSLVDDDGQVDRLLPVASREQMQGFSHVFSTHTRKNLNDGHLWFSIFLRPAGSRFTRVQRTACCLMALWLEMLVNIMWYKVIPPTPSSSAINVGPFSMSPAQISIGIQSSLIVFPITLLVVQIFRKVRPRQRQKSHRRIIKEQQEELKKKYRVGKEDAISQSHVTIENSSPNVDDTISTRSKANLLDNQTDNAPTDDPTVLIKTTASNPAQKTSRKKKQKFSFPWWVVIIGWCICLTSIATASIFTVFYGIQFGDQTTKEWLTSLVVTFITGILCTQPIKILLVAVFVALIIKSPNADEEDGIDEEEDDPELGKDEMWLHDLSSPSQGKTAYKPPDPANLERIRVQRIKELKMYNILREICFYIIFLWTLMVFSYSSIDPFAFYMKDQYVNTLNNADGVNTFDKVTGVKSFWRWVDAGLVPNIYAGKWYNGQMDPYQAGFFGDRQSYILGKVVMRQVRVKEGLCEVHEELEETIAECNEAYSFSNEDTVDYGRAWRDVNDTDETAESYRYTSASDLDGYPFLGIHALYGGGGYVVLVDGSQSQMRAKFRQLYNETWVDKYTRAVFIEFSCYNPQVNLFAVVNLVTEFLQTGAGQPMHRVDIIRLLTYSEGFGLVRIICEVMFFCFILFFIVKEVRNARREKRQYLKNFWNWVECAIIGFSIGSAIIYFYRMYITNGILDTLKEGAYRYIKLQYVAYWNELLGYMLGWIVFLATLKFLKLLRFNRRIGILSSTIRNCSTDLMYFGIMFGIVFFAFATAFYLIFSSTVYDYSDFIFTCESLMSSILGKFRFGELVIAESMLGPFFFFSFMTSMSYILINMFLTIINEAFKVVNADISKQSNEYEMVDFMIRRLKLWTGIGKPPVTGGDKKPGEGEDQEDGPKKEPDIVDEFPEKVDQLLNSIAKIYFNHETFDEVIRGMGQKGKKGKKPKKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWW8</accession>
    <name>A0A914AWW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068212.1">
        <property type="nucleotide sequence ID" value="XM_038212284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212284.1">
        <property type="protein sequence ID" value="XP_038068212.1"/>
        <property type="gene ID" value="LOC119737729"/>
    </dbReference>
    <dbReference type="GeneID" id="119737729"/>
    <dbReference type="OMA" id="CNINSRA"/>
    <dbReference type="OrthoDB" id="10036053at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13500" checksum="31904DC4A2340E63" modified="2023-02-22" version="1">MPPKPSGKGQKKAGKAKAAPSTNKKRKRKRKESYGIYIYKVMKQVHPDTGISSKAMSIMNSFVNDIFERIAGDASRLAHYNKKSTLTSREVQTAVRLLLPGELAKHAVSEGTKAFTKYTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXY7</accession>
    <name>A0A914AXY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068379.1">
        <property type="nucleotide sequence ID" value="XM_038212451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212451.1">
        <property type="protein sequence ID" value="XP_038068379.1"/>
        <property type="gene ID" value="LOC119737833"/>
    </dbReference>
    <dbReference type="GeneID" id="119737833"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF10">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="411" mass="45240" checksum="379F201E745532B7" modified="2023-02-22" version="1">MAADHSWTSMVYDICIVGAGLWGSSAARHASLPGRKVCLIGPSEPLEKDRPSRDIFASHYDVARTVRKCQGSNHFRSLMTMRAFKGLQDLEGTTGIQLNAAAGHIFYGKDIESKMAPIAKEEGVLLTAEDVHQRYPFLDTSRYGDTAMLFPINGGHANPRMIVHAEQKAATLQGCDIFDDVVESVGESGSHTHGEPVMRVLTKNGRHLLAKKVLLCTGAFTQLKDLLPPSTELDFGIDGTFTVRLEVGEDDLEKISSMPTMTSFTDPEWNCYMLPPIKYPDGKYYVKIGPLNQDQRRLTSLKEVKDWFLSKPDPKLVEKYRDLLLSIVKGFNPVSVKADMCVCSRTPTGLPYCDMVSPRLGLAVGGNGCGALLSDEVGRMAAEMIAGGENWNRDIPREMLKAQFITPPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZB3</accession>
    <name>A0A914AZB3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069042.1">
        <property type="nucleotide sequence ID" value="XM_038213114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213114.1">
        <property type="protein sequence ID" value="XP_038069042.1"/>
        <property type="gene ID" value="LOC119738276"/>
    </dbReference>
    <dbReference type="GeneID" id="119738276"/>
    <dbReference type="CTD" id="121411694"/>
    <dbReference type="OMA" id="QWINPKK"/>
    <dbReference type="OrthoDB" id="10013535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="19480" checksum="DB6071F7D5A55199" modified="2023-02-22" version="1">MNMEVSNRDPYPFPKVQNDDDFIGTGTFQKQPYTQPTHLAQRTDPWNRLNTTSTLSSSRREVYHHDPKAPRDSLDFVLKADYDHHGAFLKSKNETLVQPETIGENHGRILKNRKKEEPRLIDPMNPPTVDSVIEDPKRESIHSTKGAIDSHHSAATNAGYSRKHDGGFYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3E3</accession>
    <name>A0A914B3E3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070319.1">
        <property type="nucleotide sequence ID" value="XM_038214391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3E3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214391.1">
        <property type="protein sequence ID" value="XP_038070319.1"/>
        <property type="gene ID" value="LOC119739439"/>
    </dbReference>
    <dbReference type="GeneID" id="119739439"/>
    <dbReference type="OMA" id="CEMINIM"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="503" mass="55914" checksum="2A1A5E6B684D6A4C" modified="2023-02-22" version="1">MVIRVRPIEDDISIVSFNTEEVNIEREPKRATEDGKQTAGRDGSRTGRTYRSSRLSKYLSTWTSTLPDAVGITGIQFIVSNQDHFLRRLVWLVALLGGVAAACYQTADRALYFASNPKSVDFEIKYISPLTFPAVTICNHNNYRNLAVYSNVTYHPFASLLTEYSNTAHFYQPVNYSTYEAALAKVNTTEMYLQLAHEMDYNQMLIIAFWDGLGLTPANFTRVITDFGVCHTFNAGLDGEEPLKQRVAGKGHGLSLMLDAQQYLYYYSSKSLQVSAGFIVAVHNQSDVPQVDSLGVGVAPGTEVRIGLKRTEAINLEPPYGECGSKELKYFSSYTKNTCRQECLIDYVLEACGCVEPYMDVSGDLPVCNPAKVFSCVFVATDSFNREGTCECPIPCYQTTYTTSLSASTFPSDFYIQTLVDLYSESGATADYFSSNTLKIEIYYEELSVESIKQQEAYTFFALLCDLGGALGLWLGGSILTFVEILDHFGHTTFVRGAGFQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3Y6</accession>
    <name>A0A914B3Y6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia-and flagella-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070742.1">
        <property type="nucleotide sequence ID" value="XM_038214814.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070743.1">
        <property type="nucleotide sequence ID" value="XM_038214815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3Y6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214814.1">
        <property type="protein sequence ID" value="XP_038070742.1"/>
        <property type="gene ID" value="LOC119739762"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214815.1">
        <property type="protein sequence ID" value="XP_038070743.1"/>
        <property type="gene ID" value="LOC119739762"/>
    </dbReference>
    <dbReference type="GeneID" id="119739762"/>
    <dbReference type="OMA" id="REDACRY"/>
    <dbReference type="OrthoDB" id="68437at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039586">
        <property type="entry name" value="CFAP46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057466">
        <property type="entry name" value="CFAP46_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15977">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15977:SF15">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25439">
        <property type="entry name" value="TPR_CFAP46_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="70007" checksum="96F207A62DA06D5E" modified="2023-02-22" version="1">MDSNIRQLLSAAQQYGVESEGSFLHQAYDQLKTAAETKPTSDGPLPFGQDLYVLCAEIAFQYGLVDITKECLKMFFMKASPPNQFLCRAYLCQAQLLAPTSAEDSTQLEKAVVYLLKAINFAKENQRYHFLVYNASVLFWQFCRPFLKPGYRQYLSISLHSVVKALDDIDDKDYEWRAQLMIALIECHVDAGRVKEAAEVSKATAEFTKTNVAALYKQVLGLQIRHQLVDHSKLIKDIKQSGDLTAYYKLVKLRVSLEQKEISDFEVQGDKILRQILMEEDPSRSNSALSGRKTATPVSVSEEVSTKSQSAGDGSVPPRTNKRAPAVPAPAAVTAAAAAPTQPGTAVSCTERVLTVRSVVSKWRPLPTTPVSKWEKAPLLLELANLCIEYDQPDLVARCLDGMKNTHIKDKGMFIQMEFIECSLMVLKLRERQESYSKMSVEVRIQAINRLTEALMNAVRYGDPNIIQAGCVTQWNLCLPLLQTNLREHCRKPLTVVAEALENIQSLLVLLRCQIHTELAKCEEDEEQIQVAMEHLKKALSLDDGGQYHERLETALHRLKLRAELYKPPDSMEDQAAMIIEQARKSAESGTVRMKRSLLVKAGQALSPDAFLLVLESENEIKGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6N2</accession>
    <name>A0A914B6N2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071866.1">
        <property type="nucleotide sequence ID" value="XM_038215938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6N2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215938.1">
        <property type="protein sequence ID" value="XP_038071866.1"/>
        <property type="gene ID" value="LOC119740586"/>
    </dbReference>
    <dbReference type="GeneID" id="119740586"/>
    <dbReference type="OMA" id="NDHIMVG"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926474" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="263"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="40648" checksum="F2C2DBB576B99E59" modified="2023-02-22" version="1">MMFILIVLSVFEVFVYVLGATNPPNSKSEEQLEGPICSLSCLCLTSSSAVPGIPGSHGIPGLPGPVGPKGDTGSKGDPGPQGDPGPKGDRGPRGDRGPRGYTGSQGDRGPLGARGPAGPSSANGAKGQPGGKGDQGDKGLRGDPGPPGEQGPKVDLEHVGYYRPQQQTETQAAGPIGPKGDKGSKGLKGDSGPEGDEGLRGQDGPKGDKGEIGEPGPACTSCVTYTVNEKRNRPTGDTRIPDDKGDNDHIMVGLRQSEPTIDTSTSKLAFTAARSSSVRANAGDVIVFPRGDVITNVGDAFDGDTGVFTSTRGGVFYFAFSVCRFAAIKNAAVSLMHDGAPVVSVLGGALNGNSDQITNAATLELEVGDRVWLEVVTDETTLSSNEKRCTSFSGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B759</accession>
    <name>A0A914B759_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038071650.1">
        <property type="nucleotide sequence ID" value="XM_038215722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B759"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215722.1">
        <property type="protein sequence ID" value="XP_038071650.1"/>
        <property type="gene ID" value="LOC119740422"/>
    </dbReference>
    <dbReference type="GeneID" id="119740422"/>
    <dbReference type="OMA" id="CPFSHFD"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF4">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="702" mass="78341" checksum="C33BDE1824C33FF2" modified="2023-02-22" version="1">MAFYIKPPGGIEKLQNLAVYGKKRLRFLQQVLRCDSSADFRGLLDCADTADDSECLIEGTTKDRVSHFLLRLACCQDSEMASFFVRAETELFCHRFASMNLTELVHLFKSTHCFLCRLCRHHSKNSRLFVVQSGQSSSRTVCIDLLKILKGMIADGLTWEDVVNRYLEGCRSEVIQVPFEYALSLVASRSVVLERGVAMVPPADILKVLASLFEELISNGMVDARHSVHDVAASDERMVELFRELRHLYYSGSRLTGVDWTLDSGSVALEDIDNLSGCFPPCMQHLHRMLRQKHRLRHFSRIQYTLFLKVVGLPVSEAVKFWRREYSQPSCHHGDSAGCTHTWQRDGRRYTYSIRHLYGLEGSRVNYKAHSCRSIQECSIGHGEEGGCPFSHFDDAHLRNVMSYAGIRSEEDTRQIIDLAERGKTQAACRAFFRKSVAVSLARLLKSNVSEGNSSSDLDKREVDEKEADAEDIDLQPCNEKKPSVGMGGAVASTADDGRENANVTKQSENRDASGSQSLRGSQASDRVPSWKDADLREDGSFFSVTNETTSSKDQLLMHQVRTGSEDYSDKQRADSDLAGEGSIPSSGKHSDILPTRHQHIEVTSETVTGNSRDSKAAEIFEGVPPPSATRTSNSSNNHQPIHQIGQPKTDSGSRGDSPDETAPSSSSITILRDVQIHKPIDYYRSYVQLLASLQQLEESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B784</accession>
    <name>A0A914B784_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038072008.1">
        <property type="nucleotide sequence ID" value="XM_038216080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072009.1">
        <property type="nucleotide sequence ID" value="XM_038216081.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216080.1">
        <property type="protein sequence ID" value="XP_038072008.1"/>
        <property type="gene ID" value="LOC119740702"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216081.1">
        <property type="protein sequence ID" value="XP_038072009.1"/>
        <property type="gene ID" value="LOC119740702"/>
    </dbReference>
    <dbReference type="GeneID" id="119740702"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1830" mass="207401" checksum="52398DD8090F14DB" modified="2023-02-22" version="1">MAEQGDDTGTEKNSATSEEMSDSPMLLSQRWQQCSSKADLNTALYQFWRDNVPRAYTSNELSVPEEDLMCQEKLLQPLEWFICNGDPSLVFQQLKKTDNPPQLCGRVFKMGEPTYSCRDCAMDPTCVLCIECFQKSKHKTHRYRMNTSGGGGYCDCGDIEAWKSDPYCSIHQRNPEKPAQDPLEHLPVDMQSYSSALFCIILHYCCDMLLQDDLEVPVEDLRPKTLEDTYCTMLFNDEIHTYEQVIETLRKAVNCTPKEAVDFATIVDREGRSTVRNGLYKDCERARTIIKRNTGLHDAKSLKVQVMHSTVVAHQTYALKLLSWLSEVASYADGLRQLQCQELMKPLHASEYTILEQIMLKDTKLWKVARIQWHKLFMSTLLMDMEYKKKFAIMFTKHYSQILHDFAEDDHDHVVSVTSLSVQIYTVPTVSRMLIIEHNLLAVILKTFVDYTQKFREGPAGGKFRFQRMNLNGLRRFQFVLIDLRYILSNKPEEWTPAVRDRVMDGITVLLDLLSAMHGMDQVVRQVGKHIEIEPEWETAFNLQIKLGPCLTLLLDWCVSDRSLLLRTYRATMTALRKIVHNCQEREVEVADHKTKCLVYNVSTKPITVHCTLVRFLAGLQLELGRYNLSYLSDGLLPPHPLSPLELMEEPLRTQVLMAQVNAAMWRRNGYSLLNQIYYYQNVACQREMYDKDIIMLQSCACLMDSNDFMIRALDRYNLVRFLTVEFEGSSTPEDIQQRTLGLAILEEFLHLLIVLVSERYIPGVGQVTRADRVRREVLHQLYINSMSHSEIVKALPKDVRRNHCHETGVEEVINSVANFKKPTGTNSKGLYEIKPDCLAEYSPFFYHYSRVDQSKSEEQQRKRMKQDKPVQVACPPLPPLPSPNFKNLPHLLDSEVLVSVLHTIVRRAVERIRQIYSEQSLQRALFLTGLAVLEEKRHAKMGEEFHFLEKAVKGEPSLLNLLKNLTGNSTVEPHKELLAWVLQNITELQLMRGDTATASLAPSCPAPKGQDQELLRQQQAERQRRSELAMKKRAHAMDQMRAMQRSFIRQNPEFFEQTLEGAREERTASTSSMDTVDMFLKSSSMEDAFVALGPSHSEPLLDETSKVTCILCMEESEIRVDGDSLVLPMFVQRSTVLAQARNKDLGNPDELDPLFVSAQLTWGVHANTCGHIMHADCWQGYFESLVIKEQRRTFRFRNNLSYDLTRHQYLCPLCKTIGNTVIPLIPPLQALLPEEESDTSCSAFQEWLHLIQGMVRSGVKPPQQSRSDPLDLSTSAEGSTADMEGHIGSTVKMEKLDSEDLDRQIFTSTGLLETLGDAASQTMETLETLGDAAKTLGDAATQKFQKFCALLQGSNFPFSKSVQEMIRMFSKTAYTVGLGVMPDDENERVSILGWNVCAYSIQSTEVLLRSKGKPLFGEMASRQTEGLKALVRFAMVNTFYCDQNHIQKHVVRLLSVFSAEHANTGPCLLDLDMFTLLVSVCLSGATMQKGDSATGLKATISTIPIEGHHALRAVLTAHIVQILLTVQIDSQDEESSMDQDGCTSQHAQVMLQAYTRLRTLAGIPVDVQPDAWRLLDVVRTSCLPLLRCATIFFRFVTGIPTPTELQATCLDEFEQLCRYLAVPSDLSSLVSNEQEPIMQDLIKAWCQHPDLKSQLSDTSADVIRFPMVVNRLIELPEDYSDLMNNVSMFTCPKASGAQSDSRAPALCLVCGAVVCSQSYCCQTEIDGETVGACTSHAITCGAGVGLYLRVRECQLLMMSAKNKGCVHQTPYLDEYGEPDLNLRRGNPLHLSQEHYNQLHETWLSHSIPSQVAHRLEANNSLLTIDWQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B801</accession>
    <name>A0A914B801_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072109.1">
        <property type="nucleotide sequence ID" value="XM_038216181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B801"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216181.1">
        <property type="protein sequence ID" value="XP_038072109.1"/>
        <property type="gene ID" value="LOC119740768"/>
    </dbReference>
    <dbReference type="GeneID" id="119740768"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="37283" checksum="1D1062821A196F1C" modified="2023-02-22" version="1">MAEVENLSAVLKKKGELVLENTPIPLPGKNEVQLKMAAVGICGSDVHYLVNGRIGDFIVKSPMILGHESAGIVSALGEGVTNLKVGDRVAIEPGVPCRMCSFCKEGRYNLCPDVFFCATPPDDGSLRRYYCHAADFCFKLPDHVSLEEGALLEPLSVGVHACRRAGVRLGSRVLVLGAGPIGLLALLTAKAMGATHIAITDLDQGRLDVAKKLGAHHALRVDTRDAEEMARRVEAALGCKPEISIECSGAEPSIQTGIYATKSGGVLVLVGLGPPTVNVPMVSAALREVDIRGIFRYANCYPLALEMIASGKVDAKPLITHHFPLEKTLEAFETSRTGAGGAIKVMIHCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B830</accession>
    <name>A0A914B830_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Diacylglycerol kinase</fullName>
            <shortName evidence="24">DAG kinase</shortName>
            <ecNumber evidence="24">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="22">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="24"/>
    <dbReference type="RefSeq" id="XP_038071592.1">
        <property type="nucleotide sequence ID" value="XM_038215664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B830"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215664.1">
        <property type="protein sequence ID" value="XP_038071592.1"/>
        <property type="gene ID" value="LOC119740388"/>
    </dbReference>
    <dbReference type="GeneID" id="119740388"/>
    <dbReference type="OMA" id="CTPNLMR"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20802">
        <property type="entry name" value="C1_DGK_typeIV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20855">
        <property type="entry name" value="C1_DGK_typeIV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000204">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF80">
        <property type="entry name" value="EYE-SPECIFIC DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="26">
        <location>
            <begin position="322"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="934"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117277" checksum="272AB94FB4AD0A5C" modified="2023-02-22" version="1">MSAAVHAKEHRGGKMARRSSYFMKRMKPRSHSLDLTALQRSGIPLPSVQRDADSDAETDGRLPSGLPSGLPHRPDSFKKAISKSNAYASHLHGFPSHHLPAQRDYTATEKEIRTTVDWSENAISGDHIWTETNASGDFCYVGEQDCLVSQYWKTGSRRKCAACKIIVHTACMLQLERINFKCKPTFRDAGIRNYRENQVVRHHWVHRRRQDGKCKQCGKSFQQKLFQQKEIIAISCSWCKVAYHNKVACFMMQQIEEPCSLGIHASIIIPPSWIIRLPKQRIQGSFKSSQRKKKKPSIKRKSITKKEEGKMRPFIIKPIPSPMMKPIIVFINPKSGGNQGTKLMSKFQWLLNPRQVFDLSQGGPREGLEIFRKVPNLRILACGGDGTVGWILSEIDKLKFKPFPPVSVLPLGTGNDLARTMNWGRGYTDEPISKILTQVEEGPVTQLDRWNLTVDKNPDVELTKEDREADNNGPLDVFNNYFSLGADARTALDFHESREANPEKFNSRFRNKMYYARSGGTDLLKRTSKDLTKQIMLECDGIDYTSKLLELKAHCILLLNIPKYASGNTPWGNPSVHTFEQQRHDDGFLEVIGFSPSQMAALFVGGHGERICQCREAKVITNAMIPVQVDGEPCRLAPSIIHVSIRNQANMVLKPKRRGSMPINTDTPLSNDRLRIQVSRISMFDYERLNYDKEKLKKASVPLGIIVVDSDSNLEHIRAHIDRLLEVYILQDSNANGSASSLSPTWCFLDSTTADRFFRIDRSQEHLHYITDISSDDLYVLDPERTKPSNLSPESKSGSMPDLLVQQEVLGAANRTPSPILKLPQAHSAAQLLQARSDSTDQDEIPNLHEGAIGILSENTNYENEYQPATSSSCEAIVSNSSPQPPRRDTLCVSDTAHLNPLDKTLMDVSKRGDVAKFSELHRKGAYLMTVDQHGMNALHHAARFGHKDIVQYLIENAPVSILDAVDFEKNQTALHKAAWYMRRTICAMLVEAGASLTKTDYQGNTPRLQALKADDLELAAYLESRERYQLMLSEDHETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B848</accession>
    <name>A0A914B848_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071995.1">
        <property type="nucleotide sequence ID" value="XM_038216067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B848"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216067.1">
        <property type="protein sequence ID" value="XP_038071995.1"/>
        <property type="gene ID" value="LOC119740689"/>
    </dbReference>
    <dbReference type="GeneID" id="119740689"/>
    <dbReference type="OMA" id="ATPEWEN"/>
    <dbReference type="OrthoDB" id="5990267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="52083" checksum="B2B97896A5993BB5" modified="2023-02-22" version="1">MMLSGASLSKKTSAKTKMTTEHLKINERPETTSEADIALVYVNMHNAPQELADRPIVTTLAQYGQVIGHRRGHWPATPEWENGIRHFRMTLCSPIPSYIKVGPFQLYVQYDGQQKTCRRCGKPGHLAANCGTLTCFNCRGQGHRSAECPLPKTCTICSSENHTSFNCPTSLARPTSTSAATNMRPGTMVFPPSRELVSKTDFPPLSTGDSETEEMEISTKAQGFWDEAVKSGAASSKPTPRPRPTTRSITASSGKPSPTPSKIPTASKPSAEGKPLAANKPTAASKPPSTVGRPSATSKPSPTSKPSPASKPPTANKVSLTKAKPPSTAGKPRSASKAPAPSKVTSKSASTASKSATTSKVPTTASKSSLETTIENAQKTPDEIIEGPASQSTQDTWDSQDTFFVKYSSGKHALDWADIKKDNEKLEKCLVQDRDSDEGSTISTSSVASKRNLSSSSTDENLEDEKRFVEVLGNRKKKQARKTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B922</accession>
    <name>A0A914B922_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038072678.1">
        <property type="nucleotide sequence ID" value="XM_038216750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B922"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216750.1">
        <property type="protein sequence ID" value="XP_038072678.1"/>
        <property type="gene ID" value="LOC119741082"/>
    </dbReference>
    <dbReference type="GeneID" id="119741082"/>
    <dbReference type="OMA" id="HHYIFGK"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="294"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="832"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1123" mass="126605" checksum="8704ED72208B41D7" modified="2023-02-22" version="1">MAESNTTVNAFKKKQAQRPNRPTWSNQRQTSARSSSTQQQKPRKPCGNCGTFHKRRECPAYGKTCHKCNKKNHYADYCRSSRHVYTVNPDSYSEEDEPAVDEQELFYVRAVDNTNLNLKHDIHATLVVNNTHVPVQLDTGARCNVLPMNVYNVIAPPKSIDNSKSTKLIAYGGTELHTVGLATLPCRVDSSLTDHNIDFHIVDTQVKAILGLTDCLRLGLLSVNNLVYHVSNDTTSPQVFKDYEDLFDSSLGSLPVIYTMTIDPNATPVVRPPRRIPAAMQDKVKSELQRMTTLGVITPVSEPTDWVSSMVATHKKNSEEIRLCIDPRDLNEALKRPHHPTRTVEEVAAKMDGATVFSVLDAKCSFWQIPLDYESSLLTTFSTPYGRYRYLRMPYGLCSASDVYQRTMEQIFADLPCSIIVDDILVGGRTKEEHDRNLKTVLDRIRKINMRLNPTKCRFGLEQVSYVGHVFTASGLKPDPAKVSAITDMPPPNDVTALQRFLGMVTYLAKFVPNLSDLTAPLRELTHSDIHWCWLEQHNAAFLAIKDKIANAPTLTYFDVRKPVTLTCDASKFGLGAACLQEGAPVAYASRTMTDTEQRYAQIEKELLAVVFACTKFHDYIYGKDIVVETDHQPLVTIVKKPLLSAPARLQRMLLRLQRYNITLVYKKGKELFLADTLSRAPLTTTGTETDDLQVMTLLSISDMRLEQLKKATACDSAMQQLTDVISRGWPSHINNAPPKAHPYFAFRDELVLDRGIILKGHKAIIPKSLRAEYIQILHEGHPGIEATKRRARDVVYWPSMCLDIEQSVSGCTVCNATKAHQQKEPLKSYPPPSLPWEHIGVDLFHWNGMDYLALGDSYSGWFDFASLDNTCASTVIEVLKRQFSIHGIPRIVISDNARQFDCFAFKQFAQSWGFQHTTSSPHFPQSNGLAESSVKRAKQLLEKTKRDGSDLYRNLLNIRNVPTNPQLGSPSQRLMSRRLRTTIPTPTPLLKPAIYTRVTAQLRKRQQQQKSSYDKSAKPLRPLKPGQVVRLQSPKGHDQLGIVQKHSRNPRSYIVNAQGTLYRRNRRHLLPVPEPPPQQQHSPDFYLPPQDPLPQPAIPHAPPPQPVLTRSGRISKPNPKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA00</accession>
    <name>A0A914BA00_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072819.1">
        <property type="nucleotide sequence ID" value="XM_038216891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072820.1">
        <property type="nucleotide sequence ID" value="XM_038216892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216891.1">
        <property type="protein sequence ID" value="XP_038072819.1"/>
        <property type="gene ID" value="LOC119741180"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216892.1">
        <property type="protein sequence ID" value="XP_038072820.1"/>
        <property type="gene ID" value="LOC119741180"/>
    </dbReference>
    <dbReference type="GeneID" id="119741180"/>
    <dbReference type="CTD" id="22796"/>
    <dbReference type="OMA" id="CWAEGVY"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="767" mass="85817" checksum="3C6BBC932CA080A8" modified="2023-02-22" version="1">MSSGASFKLMPMPTSATPLCFDKEEFMKDSFDVDAFVADCRRRVQLETLREDLHIYFKSLKNAMVELINKDYADFVNLSSNLVGLDKAIGNLSIPLGQFKEEVLTVRQGMDDAIRVVEEKMAARARIREKKAILQRLINITKSVEKMESILKIAGSSVITDGEDGEDSIELSGQQIERVASEFNQLQYYVTQSKGLPLVEKIRPRIAAITVTLQHSLEKSFQEGLETGQKDILKQCLRTYATIDKMRDVEALFRKIAVRPYMNEVIHEKSLQNQPQGLKGLYARVLDFIPKHCRLIRQVTSPTTSSSSQDVVRGYDFLVNAVWPEIASSLETRTTSIFAAGNPSAFHEKYLATMEFVERFELQCGSQASVKRLRAHPSYHSFMTRWSLPVYFQLRFQEIAGSFETALMTPFNTQAQEATSDLELNAFQTLWQCLHRCWQQDVYLSPLCHRFWKLTLQLLSRSAVWIDEVYVSEVATEKPETDPSKPSDTAKLGTTSASSSDPSSQSDSIKATATVTAAGAASTAASTSTAVAAAAANPPVTVAQIVSLVVDVDHICSKLPALFDRIILPRVVAVNCKFIDILSDAFKESQESLSRQQEAFLEYIAKDVCSQCAVHLKSANDIPRLYRRTNRELPNKPSAYVSNTLKPMQLFVDEHGVKLREERRNQWLIGILTSICQGYLTISSELLSSVKKMEDSLKRLKALRKTDAAAAPTQQGTSDDDKIRLQLALDVRYFGDQIQTLGVSSADIHPYQELLQLVTSSVNSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAY1</accession>
    <name>A0A914BAY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038072995.1">
        <property type="nucleotide sequence ID" value="XM_038217067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217067.1">
        <property type="protein sequence ID" value="XP_038072995.1"/>
        <property type="gene ID" value="LOC119741317"/>
    </dbReference>
    <dbReference type="GeneID" id="119741317"/>
    <dbReference type="OMA" id="SHTEVWH"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037403272" description="beta-glucosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113682" checksum="4E66991931BB44AF" modified="2023-02-22" version="1">MGTRPTTSLLCLLALALVSAAVAEDKIEFVYPDIYNDPERDTFLYGTFPEGFVWSSATSSYQIEGAWNVSDKGVGIWDTFTHEGGHVANNDNGDVACDSYHKYKEDVALMKAMGLHYYRFSISWPRLMPDGTAASLSTDGVCYYNDLINELVANDIAPMVTLYHWDLPQALQNHGGWVNETIVDRFNDYARACYENFGDRVKLWITFNEPWIVSLLGHGSGAFAPGIAEPAITVYTVTHHLILSHALAYHTYRLDFKATQNGQVGITLNTDFIEPADRSKPADIEAADTTLQFNFGWFAHPIYIDGDYPEIMKTNIARKSAYQGFEKSRLPEFTTYQKALIKGTGDFIGLNHYTTTLATNATPDVGDRNASDASYWSDQNIWSWKDPNWPGSGSSWLQIVPWGIRRLLKWISDEYGSDIPIYVTENGVSTKDVFELEDTIRVDYYKSYINEVLKERRMMFKMCSVCLSAVSLYLAFVAGLATALAEDRIEFVYPDAYNDTTRDTFLYGTFPEGFVWSTATSSYQIEGAWNVSDKGPSVWDTFTHEGGNIENDDNGDIACDSYHKYKEDVALMKAMGLQFYRFSISWPRLMPDGTAASLSTDGLRYYNDLIDELVANDIAPMVTLYHWDLPQALQDHGGWVNETIVELFNDYARVCFENFGDRVPFWITFNEPWIFTLLGYGTTMFAPGNVVDPSVKIYTVGRHIILAHATAYHTFQREFASTQTAKIGITLNSDYFEPADRTRQSDLDAADRVLRFNLGWFANPIFKNGDYPEIMKTEIGAKSAYQGFSQSRLPPFTDMEKEFIKGTADFFGLNQYTTMYVTNTTVDDSLPSQASYLTDRGVYTYRDPAWPGAASDWLKIVPWGIRRILKWLADEYGRELPIYITENGISTHDVLELDDKIRVDYYKAYINEVLKAIELDKVNVKGYTAWSLMDNFEWASGYTERFGMHYVDFNDPERARTAKASAKFYATVVAENGFPDPSVSGAPASVTVSLAGLVASIAFALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCC6</accession>
    <name>A0A914BCC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073087.1">
        <property type="nucleotide sequence ID" value="XM_038217159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217159.1">
        <property type="protein sequence ID" value="XP_038073087.1"/>
        <property type="gene ID" value="LOC119741415"/>
    </dbReference>
    <dbReference type="GeneID" id="119741415"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="20229" checksum="6C99EC3B8E967B8E" modified="2023-02-22" version="1">MAVLMNSYFFYIFYSDSGRCIIQWQSTSWRTFVGVANFSVIYIFPLRLMGFSYWRIMRNLHKSAMNMRQSTSSNGTDNQLSRDLLTARKKVVKMLLTVVVTFAVCWAPNQFMFFAYMCGWNLDFSAWYYHASVLLAFCNSCMNPIIYGFKSKQYRGALKRRLAVETKSGFVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BE96</accession>
    <name>A0A914BE96_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aftiphilin clathrin-binding box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074548.1">
        <property type="nucleotide sequence ID" value="XM_038218620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BE96"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218620.1">
        <property type="protein sequence ID" value="XP_038074548.1"/>
        <property type="gene ID" value="LOC119742554"/>
    </dbReference>
    <dbReference type="GeneID" id="119742554"/>
    <dbReference type="OMA" id="EEWHESK"/>
    <dbReference type="OrthoDB" id="5917212at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046359">
        <property type="entry name" value="Aftin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029205">
        <property type="entry name" value="Clathrin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156">
        <property type="entry name" value="AFTIPHILIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156:SF10">
        <property type="entry name" value="AFTIPHILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15045">
        <property type="entry name" value="Clathrin_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aftiphilin clathrin-binding box" evidence="2">
        <location>
            <begin position="597"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="841" mass="90343" checksum="709B7579F302E54C" modified="2023-02-22" version="1">MATSKTFIPMVSASPPPLDGFDDDEDDDFGSFASAGFSPEKPKPVAANDTHFFPIKEEPLDVEQDEEFGNFATFESNNQTGHTHTNGDDVINSSDSDLEFGTFPVLKKQTESIDNEKSKTNVKAFHSFTNGGDPNEGDNSWGDFTNSPDRKTDVVITDNSSEPENQNLQSSHSKSKTSKDVLSQGTGDNKETCDDLSRNSVNTNSSNSYSDDNAMDFHSPFTSDSHSQDTDSSDFQSSQSAKTERSEVWSKAKTPELSHSGMVDVKSHIEEPPKAVSHEESMNEPFTVEPKQGGVGLQTVEAESVSEDEFGDFNSVTSVNSQEKPNKNVISSQTSDQSHQSQDSDSQCAKSDISQGDSQHSVGGGSSISRSPEPPADDWGDFDSVPTSTKEPTTKKSEILGPVTSHDDGDDDFNDFESFNEKPTSEDNSTSQTQDDSSFGGFGTFHTSASWTQETKPTDTNQPLKQPTQATPSTTSNLSKDDFGDFGAFQEGSSTQAAPRAAGDFQAFSGSQNEAKSDLSRFSLAFDTVSASSSQAPSSRVDRVFKTCFPGNGSPLAASLVVDLLIDIVVKGRQEAEDQSAISDSGKTHASRQNDNSNVWNCLRDLERTNALGYQWAKSGNSKQLLGSLGVDSRNILASKKTGMPIFAPNLGMLMPSKPGEKQERPASSGSGLVEESPEGEPGSTPAGTPQDAVPKVEFDWSNSGLTNPLDANGLNLDIFSKEGSTSANHYVSKSKHKSGWFRRKAPPLDPEILKLEKSGPPQPLPAQKNHKPLDDILKSSATSMVRQRSQRDAGLSSEANRVLDGLPSLSFMHAKVLMFPMRPLEGGTTAGSAPSQGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEU8</accession>
    <name>A0A914BEU8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074476.1">
        <property type="nucleotide sequence ID" value="XM_038218548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218548.1">
        <property type="protein sequence ID" value="XP_038074476.1"/>
        <property type="gene ID" value="LOC119742533"/>
    </dbReference>
    <dbReference type="GeneID" id="119742533"/>
    <dbReference type="OMA" id="WRRESEI"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="7">
        <location>
            <begin position="660"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="129081" checksum="37C7A56DAE856BD3" modified="2023-02-22" version="1">MESVVVFVAVWWIANMVSTIASKKAVSDIKPDVFDSLTSCTPALKDLRWIELTMLQHLLGALLANIWVVVIRGKSVFPKNTLNPKHMLLTVIGNAVGNLATNASFAAVSSSLTQVIKSCEPVLTFVFTLLLYKKGGNLTRSVLFSIIAMVVGTCLFISGEVSFNIYGLGAAVISSIAFPIRNIYLKKLDESLDDPLQKFAVISNLSVLILLPFAIMSMSSLDKLPPVESYTAAIFHFIYNAASITVLQAYSPVVHAMLNLSKRMFVIVANMFVFSTPLTSWTVTGLLAIFIGHYIYQGGRIPLKVIQMPSTKQWFSLAVIISCVSSFCWFIGFIHPIRPINPNHIRLDKPSPQATTAWVYERPIPHNVVENFEAFLDRNPFMTMKVFCGTSQCMEAVQDLDNARITAKFLVLPEIFKNTPLKLWLARHPIHKILTGVDFEDHVYEAVRLALLWHHGGIHFHPSIKLSEFTIPGHQEAWVSIGTNLTQTTTHGILSLSQFPAHNAFIANLTEMFCREYFQNVTNADPRSLQQLNFETSVNDVYNQFCTSEDHPCPKGMVTDLERLSLLDVKRRHFGTISYSRRAARVAPNLGDEVQGFPGIQFLPFVDRFVDRENFGGSKEQNRIRLFLNAWYGDTAMRWPPPRNIDPILLSMHIHKSVKFKFKSHAKYLRAKEPIGCRDTGTLEFLERIEVDAFLSGCLTLLIKTPNIQKIHSGNIFLVDVGRTFAAHLPADIQKRAIHVTHVGTGGVNSTIMGRFKAAYGLIQKYSEADVVITQRIHCALPCVAMGTPVIFINSKNMPGDAEGVKFSRRVMGLTPLFHTMDIHKMSTESIVQWLRDFNWTHPPPNPNVSLRMRVRATNWNVIRQDQVLYDSAHKFGLLPLSTPATNTPHQLLFHFIPNITDNRTSLDRPKWRSIESIFYHYPHARIIIHSDSLQTGQFDVLTESGYTIEVHSLSATVGNDFIQSKLSIYNLGRFDGVFAKLAVLLHWGGVYIDADVILLRQLDNLMTNNLVWRGEEQNSFDLSFMKFEKGHPFLETALLKGTKRHVSQLISTYQTSLFNTWSNHFKSSVKVLSKKGVFMQFNAQNAKECLESTSGPAFESSMKLVKQDMVFAKVTRLTNLSKLKRGTICKHLYNSFCVLCNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF74</accession>
    <name>A0A914BF74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074515.1">
        <property type="nucleotide sequence ID" value="XM_038218587.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218587.1">
        <property type="protein sequence ID" value="XP_038074515.1"/>
        <property type="gene ID" value="LOC119742552"/>
    </dbReference>
    <dbReference type="GeneID" id="119742552"/>
    <dbReference type="OMA" id="RHNASDP"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22223">
        <property type="entry name" value="HkD_HkRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1385"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="198"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="945"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1389"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1441"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1583"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1598"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1617"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1681"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1745"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1848"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1862"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1888"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1929"/>
            <end position="1939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1966" mass="225545" checksum="72D8B6B8646EF1C5" modified="2023-02-22" version="1">MSTMAALEEFMSHPLVVWVTTFKDGSLDYMDLVDGIFLNDVMAQILRGHVVMGKVFVSDPRPNALKVNHEVNGEVNLRIQNLDTLMKNIKAFYLDILDQLLVMKLPNVLLISKDPMGEVAIAEMQKLLLLMLGCAVQSSQKEIFIERIKQLEIDVQHAIVVHIQEITDNAENVVNLQLGELIDQDQQDNLYKNMFSHVKRLVMERDDYAETIMELSQEKEIYQATIEGRRIVPSPTSPGSDRRHITVELAESKAKLRRTRQELEEKNEMVLEYKEEVDKYNLTVQKLRQENLELSQDARSARSYRDELDVWKEKASKVEKYEKEIARYREKLNELEYLKRRVEELREDNQLLHETRGLLEDQLEAAQHKVEKGREAEAECLRLRAQLEAMEDERDSDRTKIQELVAEVSKLQLDHKQSLDESASLGVELEKAKHSLSPLGNSLSAECNESASSRILRLERENQRLLQEIESLKDVASLQSNSQLLEMEKENKRLSRKVDMLQQTSKTDIQNSLELEQEINRLKREKQQLDETINTVRENAERQSKEWSMEKGQLEETVEKLRERNKKDIDQRVQDVEKENKKLAEEKRESQMQISKLVYENKQLDRCQEKLKEHSARVETLEQQNTELDSERDKLNRNVQTLKLMCEKFDEVEKANSVLQIEKQRLEKSVETLRANCQKLEQAEGENVQLRAEAQRLHRSLESLRNAMSRVTELESEKEDQDRKNRILQKSLDALKPTQDKATHLEVDNMKLETEKKKLESSVQLSKNKIEKLEKENQDMDSEIEQLKKNLDAASLIAKKVEELETEQKTSDTEKMGLEKERSQLSKENKRLRQSLESRERLVDEANARVHTLEQENRQLQKAINKNKEASEKLKELEKDNKEFLKQATIDKKTLATLREELVNEKIKGQQLSNDLEKLSTELDKIGLDKNKLLHEEVRLDETRYKTLQNKMEDAFQKNLQIKEERITALETKLQLSESQKQKLTVELKERGVQEVLVQRQEEQRTMSSPGDAKVKRTDSDRLHSKQIMQMKDHLVELERSNATLLAENNSLKTQLASLQSQVDSLRSENKALQNKVESVQEKQISMQSQQAKLQVENSTLQSHNASLQSQYTAMQAKLTSHESDYEKVKERLNELLTNYEALLGDHETLVQLHDTLSSEYEALTSEHKSLKTLHREMKNEIGDLRNRCRDAEMQSKEVERLQSSVREEEKKVKRMRTDNLSMSSLQLEFNSLSHAHLRLNQEYKEVEDELKKLKAQHRNLQLDYTSLQGYLNEVKDKCTSAEMDSLKLNHRCEMLNQLNSKLEEENHKLMEQLSQLLAQNSEMLVDALETKEFHHEEQHVLEEQLHNLRRQKEKLEEKIMDQYKHYTPPKKSKGLNLNFMKKIYKRGRSTDRDRRKKTQELHQDPADGLSGAEKDSLGETSSAGSGIDSLDGSAALNPDGTRRTDERRGSDDNHPVLHRKRETSGTQGHYRKSMPAHVLEAHEDPNMASRGGYSMSVEDLRRSKETRSHSVSSMEPKHQIYTSSLRKVRRRSMYDYDQPASLSPISYGYRHSQTSSDVQPKDMKEVEGEEFPTSPTCHSPTDTPPHPLLLPSPASPGQPTGTSPHSGDDNNTSCDEDSHALRDSPRGSPRDGLPPSGRSAKKRAAMLSRIKSRSREILDDMKMYGSTPNLARDFSFTEEDSPRSADADSPRSDKYNRTANGEESSRLPLPDAEPSSPHDKMETEDVITPMRQTGELQATPPQASERRRGMTAERNRHHRYSMPDAPKLVALAQEFSHSPPAPLSTSANSKGAPLASPVYSARPYPGRTEAVVESSPIPPPRSASAHKIHKPKAQYPSEGSPAASREASQKEHTPEHHRAGKTSTPETRYRSSSSRSPEAKTNKPPMAVVSPNANSNSNNAPLGWAVPSFDEGETRDRSVSEPSKMKSKTGTPTKTEQSPAPEEDQNGENKSGKKKSSVWYEYGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH37</accession>
    <name>A0A914BH37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075578.1">
        <property type="nucleotide sequence ID" value="XM_038219650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219650.1">
        <property type="protein sequence ID" value="XP_038075578.1"/>
        <property type="gene ID" value="LOC119743246"/>
    </dbReference>
    <dbReference type="GeneID" id="119743246"/>
    <dbReference type="OMA" id="TNCKQCH"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="346"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="479" mass="53880" checksum="CF24FEC45DBB13DF" modified="2023-02-22" version="1">MVVGATGTGKSTLINAMANYILGVKWEYNFRFKLVDERGEAPESQAYSQTQNIRSYTINSNDHINVPYTLTIIDTPGFGDTRGIEHDKATVEKIKEFFTHPEAHGVDHIDAVGFVVQSSQARLTRTQTYVFESILSVFGKNIEPNILLLITFFDGQPPKVLEAVQEAKLPISKTFKFNSSALFASHGDGGKSFDAMFWEMGYTSMKEFFDALNDLQPQSLILTVAVLEERKCLEIALKGLQPQIQFACEQEQQLNNDIKMLEEHEKEIEAHKSFEYVANVAKLEKIPDQQGSTNCSNCLYTCHHPCTYSRLKRFCHAMSWGNCTVCPGKCPSSDHVHENSRYHWKMVREKQTYADIENRYRDAKGRKQTREEVIKKLRADLATAEAAVSELIKESHRSAQRLEQIALNPNPVGVREYLDVLIESEKATKNTGWEKRVGSLEATKQREGTKAAVKDAAAAASGSAISSMWSKVKKTIGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHM7</accession>
    <name>A0A914BHM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075395.1">
        <property type="nucleotide sequence ID" value="XM_038219467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219467.1">
        <property type="protein sequence ID" value="XP_038075395.1"/>
        <property type="gene ID" value="LOC119743113"/>
    </dbReference>
    <dbReference type="GeneID" id="119743113"/>
    <dbReference type="OMA" id="GCPAEDQ"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="23815" checksum="C4D60CEB11CB5CDA" modified="2023-02-22" version="1">MEDPNNNEDYASCVPDYLMPDLIATKDELCPDEQSVPVFDRGCPAEDQYNPAAGWMGNQIDFPTYHSQVNGNYMESAPSGQPLQLNYDPAWLAPSFTSEGALSTNHVAEPTHVPQHPAASSSSGLHCSVCFRTFKQKLSLTNHQRSHTARQPHLCTICGETFKYKTNFKRHRRIHAKEMKICRYCGTNMESDYDLVQHEKEHRRQQKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI38</accession>
    <name>A0A914BI38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038075759.1">
        <property type="nucleotide sequence ID" value="XM_038219831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219831.1">
        <property type="protein sequence ID" value="XP_038075759.1"/>
        <property type="gene ID" value="LOC119743431"/>
    </dbReference>
    <dbReference type="GeneID" id="119743431"/>
    <dbReference type="OMA" id="HAYIIPY"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF51">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038171146" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="172" mass="19310" checksum="122BFA93CA66AF21" modified="2023-02-22" version="1">MAGKSVMFLFVCALTLITEGQAASRQKRSLPQFALMMTCATGTNPLEYNGYGCYCGSGGGGTPVDATDRCCYAHDQCYSRLKSDGHCVKETGDVYTMLYRSKQKNCGQSNVQITCKRARQYNWLESLAVFWKTNCAAGACECDRQAALCFKRNRGTFSRSYVNYHKYTRCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIE7</accession>
    <name>A0A914BIE7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075675.1">
        <property type="nucleotide sequence ID" value="XM_038219747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIE7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219747.1">
        <property type="protein sequence ID" value="XP_038075675.1"/>
        <property type="gene ID" value="LOC119743349"/>
    </dbReference>
    <dbReference type="GeneID" id="119743349"/>
    <dbReference type="OrthoDB" id="9882192at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="365" mass="41058" checksum="383AB3AC44B1EEED" modified="2023-02-22" version="1">MKAHPSVQTKGAEADWTPIQCTDRECSHSLMKAPHLHCPFCSQDSLFTEEILLKAHYVQSQSPSHSSHRRQTHHPRGYEQTDGQQPQIEYQYACINDPSQSTANGEDEGSKEDLEDETCYTEHNLSLLLQEKESLEKTLEEERTTWAQTEHRMKGTIERLRTKVEYLSNTNMSLKQQLSMIHTSSLKHPTNDSENQSILQELLQHMSEEHTQLLHHHLAQLRLYAQACALSKSAPEESAAESTVLVPDLADQSQDISHMAMMSSSEGTLGNMEQTVVMTITSEEDSEPLGNIVDNPGDTVGHYSLTLDKDVHLSPNDIPYQLTSEGLSPRHATSESGHVYQSGRTHSHHNTGCDVTQQDFHKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIJ7</accession>
    <name>A0A914BIJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Msx2-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076113.1">
        <property type="nucleotide sequence ID" value="XM_038220185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220185.1">
        <property type="protein sequence ID" value="XP_038076113.1"/>
        <property type="gene ID" value="LOC119744316"/>
    </dbReference>
    <dbReference type="GeneID" id="119744316"/>
    <dbReference type="OMA" id="SNVMANC"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12349">
        <property type="entry name" value="RRM2_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21543">
        <property type="entry name" value="SPOC_SHARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000088">
        <property type="entry name" value="msx2-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000002">
        <property type="entry name" value="Spen family transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034173">
        <property type="entry name" value="SHARP_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="431"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="510"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="13">
        <location>
            <begin position="4482"/>
            <end position="4645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="938"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1399"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1701"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1836"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2935"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3122"/>
            <end position="3143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3299"/>
            <end position="3493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3660"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3790"/>
            <end position="3840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4073"/>
            <end position="4107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4233"/>
            <end position="4296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4350"/>
            <end position="4387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4413"/>
            <end position="4440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4452"/>
            <end position="4476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3718"/>
            <end position="3749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="791"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="938"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1269"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1454"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1712"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1836"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1847"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1861"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1898"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1923"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1978"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2004"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2126"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2216"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2237"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2271"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2424"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2451"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2479"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2526"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2540"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2592"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2608"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2640"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2680"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2710"/>
            <end position="2731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2776"/>
            <end position="2792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2799"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2822"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2974"/>
            <end position="2985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2993"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="3127"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3299"/>
            <end position="3326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3379"/>
            <end position="3395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="3456"/>
            <end position="3476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3676"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3790"/>
            <end position="3805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="3806"/>
            <end position="3821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3822"/>
            <end position="3840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4077"/>
            <end position="4087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4089"/>
            <end position="4100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4357"/>
            <end position="4372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4416"/>
            <end position="4426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4645" mass="513800" checksum="76A3CD6B73C71D2A" modified="2023-02-22" version="1">[encoded data, 4645 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIR7</accession>
    <name>A0A914BIR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MABP1/WDR62 second WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075736.1">
        <property type="nucleotide sequence ID" value="XM_038219808.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219808.1">
        <property type="protein sequence ID" value="XP_038075736.1"/>
        <property type="gene ID" value="LOC119743414"/>
    </dbReference>
    <dbReference type="GeneID" id="119743414"/>
    <dbReference type="OMA" id="MRADLRI"/>
    <dbReference type="OrthoDB" id="6154712at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="3">
        <location>
            <begin position="389"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="651"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2045"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2160"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1439"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1502"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1544"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1609"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1666"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1709"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1726"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1820"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1867"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1878"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1905"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1927"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1961"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2059"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2165"/>
            <end position="2174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2184" mass="239918" checksum="2BA678F83E543F93" modified="2023-02-22" version="1">MSGNANQRPNILNLAERTSVPTKRAVRAPMPKKRSKGVPLSERVTLERVLGLTVRDNRTFACDPTTGLVVYPAGCVIVLYNPRRNKQSHIFSHSRKTITALAISGDGKNVVSGEYGHKPAVRVWDVEERTQLTELHGHKFGINCVAFSPNLKYVVSVGEQHDMVVNVWNWKDGSKLAAGKISVKVAGFSFSEDGSRFVTAGNRSIRFWYMSSKSRTRETFPLNSRAGLLGEQRNNNFCSVACGLGANQSKTYAVTKSGLLCEFNEQRLLDKWVELRTSSAYSIVASEEYLFVGCADGIVRLFSTSTLNFVATLPRPHFLGVNVSDGIDPSHMITHRENARYPAAIAITYDDVSKKVTCVYNDHSLYVWDVHDVKKIGKQRSFLYHSSCIWGAEVYPSLIAGDKEALPPGSFLTFASDDTIRIWNVDPAMNTDTFKRNIYSNELLKVIYVDDQLEHLCSTGSTASDKAESATEGKNGIRCISLSADGQFLASGDRSGNVRVHDMQFMDEVHKIEAHDSEVLCLEFSRPESGYYLLASSSRDRLIHVFNMQEDCSLVQTLDDHSSSITAVKFTQCNDRLQMISCGADKALMFRVATQNPDFEFIRNHHVVGKTTIYDLTVDPTEKYVATACQDRNIRIHNAVTGKLKRTYKGSQGEDGTLIRVELDPSGMYIATSSSDKSVAIFDFYSGECVATMDGHSELVTGIKFTNDCKHLISTSGDGCIFVWRLPWGFTHNMKERLNEMGQHMKEAPSYPQLRRGTFVIPPELDPKVAAIETRSNTHRATMLVNKGSKLVAGDGEEEQEEEYEDGEGRDETDWHAGPKLDSTADLPLWAKKQVCGEDLPSPTTYSNPAQPRGRWAQRLDSKGFKVKSEWDAHRDIELKLEDGIDRRRYTVEPENLAEQVRHFALLQSAAVAEHERLQSSLLITDAEDFVSAEEGLAGLEDQRNASNPLLQGFVTSARGSDPFLPPTGHSSSSLSPDTPEDEVNSAKEEDQEEEEEEANEVIIYPPSEESSSSPESLKFQVTESTSSLEELQRRRARSVLKKESPRSSRVIEDQDLTEVEGSESTEPVSLGTSEDEDEGDEDEAEEDDNEEKGDQEKTPTESDHSNSKAQSTPGQTPTTTSIITPTDPTEGLKTNGRDSSSPKRDEDEEEEDKDEESFLHTNYGFTEQEKFGKCLEQLQSGFASVGLHNGNHHRLSISSKFLSRSQLSHIRGVAASTRPLPSSSVGGVTAQVYLQRRKDVMAKAVDETRRRLQSMGWNSLRSKSTTTPSSSGSTTSTTPTSTPTSPNKSVSTVTTVSRSEGSSMTEASPAEADERSHTVASVTESPSVGDALLNESEGSQKGQKASEDGKQEIETDQRKTESTPVVRQPENEPALTEDSRDKTQENGVMINKMGLRDSKETEESKAVQENSITSSGESASKASTIQPVTGTKDVGDNISRSKSPSTVPAETSNSQQVSQSESVVRSDDQSRNMTSTPDPVHVPIIKTKRPVSAPVEPTFEAIEKANKENLVRSFKYNTHPGRRSISSSSKSKMDKMKARKDQPATSTMRKSTSMSDLREAKSDEESRSESPSFNMVLRSHPRSHSVERKKIRANSPAREKHRSRPDRVLPLVPGLLKPKSYEVGTASSLAKKSVRKDETPPSSPSRTGRGKRSSFGAPGEESRQSKSGGSSPETLPETTKNVTLPEKPSAKDALADKTKQLAEADISSEATVADTQTADVKDVPRSSSPSSVGSQKDADLSSNKDQADKLAMPPPSSTTIAKSNRSLRRSSATRVELRQQRRRGSSSKTKPPANDASSTEDQKVSSDSISTSETSQSDARPSSPKSRGSSYRENRSSSLREGLSPKTARKASAPTIKTDTTEESLSDPSRPPLKLKSSKDSVKDEKTSEKPSPRRRRRERNEEAVVNASNNNNTMTQLDSVDKVHSPRSRSRRRRSFEASNASERTSGVTCEGTVTAKTSETEQRRESLEQCPTSTIKEPCPDRDSSEMTLDMMKAQVDTMKTAFDQCLELCAKAQGTDSPGKSHQHFLDYFASTFSLMQAASSPTLASRQSRRHPNLSVTDDTMSDVSESSLPYDDLLRSASSSSVFMTTTATTVSSARHSEVSPSEVDALRASLSSCRKTPPPNGMTGEVEMTSAIALLDQYSSILVSLVRQKVGDEMSEESAATQTQRSLDSAIEGIVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJK6</accession>
    <name>A0A914BJK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076001.1">
        <property type="nucleotide sequence ID" value="XM_038220073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220073.1">
        <property type="protein sequence ID" value="XP_038076001.1"/>
        <property type="gene ID" value="LOC119744022"/>
    </dbReference>
    <dbReference type="GeneID" id="119744022"/>
    <dbReference type="OrthoDB" id="5967704at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="39863" checksum="B94362F389DF351E" modified="2023-02-22" version="1">MAEGMDVQTTMASGMTTGTPYTLTVVSVVKACLLAVTTTLILLGNSLCLIVLRYTHDGVSPVTKLFLISLTISDLLVGVLVGVPVVGSTALQGWPYGDAYCTVVAMCHALYFNAGMSVLAINIERYIAVIWPLRYPSIVTMTRAVIAEVCIICILVVWTLLYVLIPNRSAFYYSNFNLCFIDSDEGNDVMGQLGMTLFIALPMLITVMLHIRLFFLATRHASKVGNITLGDINSTSGASQNSESDVGQRAQSSPPTQRREGRQRVNSDRPSPETKAARTFFIMALVAAISWTPYYTTISWENFREEEVPEALAFVAQILLLLNSLWNVVIYYARNDAFRKTANRLLGCCFRVHSTNGEVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKQ5</accession>
    <name>A0A914BKQ5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076047.1">
        <property type="nucleotide sequence ID" value="XM_038220119.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076048.1">
        <property type="nucleotide sequence ID" value="XM_038220120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220119.1">
        <property type="protein sequence ID" value="XP_038076047.1"/>
        <property type="gene ID" value="LOC119744261"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220120.1">
        <property type="protein sequence ID" value="XP_038076048.1"/>
        <property type="gene ID" value="LOC119744261"/>
    </dbReference>
    <dbReference type="GeneID" id="119744261"/>
    <dbReference type="OMA" id="SECITGH"/>
    <dbReference type="OrthoDB" id="10543807at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="563" mass="63592" checksum="64EEA5F93D3F0833" modified="2023-02-22" version="1">MSGPLSRRRFSSDLLLEEDDEAIPWTYVSTQNDSSHGDVPTYTSEGVANKRRKLYRQRKDDLDVKPTSSRSRTESVELWTEVEDLSLCQAVSICLQHTSSESSLALTTENLSDLERNHPMSVFSRNVSRELQTLDISKCLAECFVPSHEHGDVLARVQSSAFRRTFMGFLNSKSRRGQSLLCTDAAESNNACNSSDSGAQFKHDLQQDLKSSPFIKPDIYPETFESDQGKHPSPSPSERNSRKKTERKSEKIDLNPGSSVELLDRQETDVLQGELATQEEGSEKFQETRRSSSRLRSKLRPEDRDTSTDNEDIPNLTRQIPQVSTDNSNDRNLSEKNLNVGPNSHPPAKTDKRKKRLPRNKQEVIQRKQSNEMVTETSCEPAKTGKIENREQEKRHEKTGSQFESAELEQPPSKVPAKMDTKCESEKPNKLTSENLPQVDTISRQLKESTSSEQEDTKASKSPLQLTPSGKAPLMATVRPLRKAQNEKDNEKRSFKKFRKKFLDRCLEVQHSGLGLTARIPGQGTNIISNVHSSLDEYLTMQHVQQSRKGILDACLMAQRDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMG3</accession>
    <name>A0A914BMG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077130.1">
        <property type="nucleotide sequence ID" value="XM_038221202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221202.1">
        <property type="protein sequence ID" value="XP_038077130.1"/>
        <property type="gene ID" value="LOC119744979"/>
    </dbReference>
    <dbReference type="GeneID" id="119744979"/>
    <dbReference type="OMA" id="QANDSCE"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="32590" checksum="958100756D499644" modified="2023-02-22" version="1">MLRYRKVFNSSTNKLILHQSFVDFLASFVFILNRFLRVTTPIPANAIGALYCKLWWSEWPLWALYVTSTYNLVAISMERYFATCHSIAHRNMLTSKRLKLIMVAAWLCGWIPEAHLVPISYQLDDSCEGFWPSRIIQAIGGVSIAIWEFVIPLSIMIFAYTRIIMELHKRSKNRVGNNSNNNDAQNMLSKANKNVTKTLFVVAIFFAICWAPTDVNYILYHSGLNENSLDSVFYQVAGAIVLINMCINPIIYCFTYDRFQKQAWKMVSDVCKRPQNRVDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN58</accession>
    <name>A0A914BN58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077723.1">
        <property type="nucleotide sequence ID" value="XM_038221795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221795.1">
        <property type="protein sequence ID" value="XP_038077723.1"/>
        <property type="gene ID" value="LOC119745446"/>
    </dbReference>
    <dbReference type="GeneID" id="119745446"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036780867" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="141"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="275" mass="27895" checksum="53FE42AA7A8FA688" modified="2023-02-22" version="1">MKICVATILSIALLLGNSVKLQASVTGPVPSDGDGPASQACQQCCQGPAAIPGIPGLPGPAGPMGPYGQQGSKGDAGQKGEIGPIGPMGERGAPGNPGSKGDDLIGLPGKIGPRGLTGLVGTTGETGVKGQKGEPGETPDNSNQRVAFTVRRTGPSDTFTNYDSNLPFDETKTLLPGTSFGLETGTFTCRVPGTYVFTFSVLQYTSSTTLTVCLQKNNDVVVTGYSGDSGSQEQVSGSAVLVLQIGDTVYLSMVGKAGSSSRGYTSFSGFLLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNH8</accession>
    <name>A0A914BNH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077495.1">
        <property type="nucleotide sequence ID" value="XM_038221567.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077505.1">
        <property type="nucleotide sequence ID" value="XM_038221577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221567.1">
        <property type="protein sequence ID" value="XP_038077495.1"/>
        <property type="gene ID" value="LOC119745299"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221577.1">
        <property type="protein sequence ID" value="XP_038077505.1"/>
        <property type="gene ID" value="LOC119745299"/>
    </dbReference>
    <dbReference type="GeneID" id="119745299"/>
    <dbReference type="CTD" id="164"/>
    <dbReference type="OMA" id="XYAPSKR"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="763"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="621"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="881" mass="97653" checksum="4BE012C1D2C2D66F" modified="2023-02-22" version="1">MSVLQALEEKLSKMPAPMRLKDLIRNIRAARTAADERAVIQKELAIIRNSFREEDNTYRCRNVAKLLYINMLGYPAHFGQLECLKLIASPRFTDKRIGYLGATLLLDERHDVHLLITNSMKNDMEHNTQYIVGLSLSCFGSICSPEMSRDLAGEVEKLLKSSNAYVKKKAALCGVRIIRKVPELMEMFIPAVRSLLNDKNHGVQLTAVVLITEMCSRSPETLLHFRKVKEIVPNLVRILKNLIMSGYSPEHDVSGVSDPFLQVKILRLLRLLGKSDMDCSEAMNDILAQVATNTETSKNVGNAILYETVLCIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALNTLLRVVQSDMNAVQRHRSTIVDCLKDPDVSIKRRAVELCFALINGNNVRSMVKELIFFLDKADPEFKAYTSSNIISTCERHAPNKRWHIDTMMRVLTGAGNYVPEDSVASLIQNISESSSLHGYIVQQLYKGLKEDISQQPLAQVASWCMGEYGDLLVGGAIEEEEPVQVRTYYVPALDLDHLKQNAYDPGQTEPLQVSEDEALDLLESVIQSTSASQVTKEYVLQAILKISARFTHSAERIKKMAAPYTQSLDTELQQRSVEFTALVTSHDNMRPGLLERMPPMERKDEKQVNGDMNGESEDRKPMKPPSVQHESKGLLELLETPGAPMPNAGLSLSPTHNQKTEPSSSGGELLDLLDTLDLSGPAPAVPGFQPLAPMPSQPAPVNIMDALGTLEPMVAQPQADLLGGLVNNISGPSIPSVIAVENPTLKIEFAFERESPDKVAILLRATNPTLNPVTSFLFQAAVPKTFQLELMTPSGDLVPPNNSGAVTQTIKVTNPSRQAMRMRYKLAYTVLGNTSQEQGEVNNFPPAMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQE9</accession>
    <name>A0A914BQE9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038077712.1">
        <property type="nucleotide sequence ID" value="XM_038221784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221784.1">
        <property type="protein sequence ID" value="XP_038077712.1"/>
        <property type="gene ID" value="LOC119745439"/>
    </dbReference>
    <dbReference type="GeneID" id="119745439"/>
    <dbReference type="CTD" id="8731"/>
    <dbReference type="OMA" id="LITGDCF"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10 12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="14">
        <location>
            <begin position="58"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="12">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="44192" checksum="452826C9836774A0" modified="2023-02-22" version="1">MAEVLEVPTAVEPTKDIGSKTEETESQNTSQQDSISDSIVAKHYNERQDVGLTERTKSRIFFLRNFNNWIKSICIADTLQRLRDSDPTARLTVLDLCCGKGGDLLKWKKGQISRLVCSDIAEVSLQQCEERFKELGNRSNNPYDRGTFTAEFYSADLSKELLSEKYEDPSIQFDLASCQFSFHYSFESHAQAETMLRNACEQLRPGGYFIGTVPNGCELVRRLKTSEGTQFGNDVYTVNFHSKDEFPLFGCRYDFHLEGVVDCPEFLLYFPLLEEMAKKYQMEIVYCKTFHEFFDEHSKDPENNRLFGKMKSLEQYPPDRNTTASSTTEGDYSHAEERLNQLKERTDRFIKLGTLSKSEWEATSLYLVFAFRKETHSQPQTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQZ1</accession>
    <name>A0A914BQZ1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078713.1">
        <property type="nucleotide sequence ID" value="XM_038222785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222785.1">
        <property type="protein sequence ID" value="XP_038078713.1"/>
        <property type="gene ID" value="LOC119746028"/>
    </dbReference>
    <dbReference type="GeneID" id="119746028"/>
    <dbReference type="OMA" id="TEMTNDK"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="270" mass="30206" checksum="06974A0293E73A94" modified="2023-02-22" version="1">MADSKPKRLALWSTTRCLSTAMVMSFGNYGNVEVFNELYAGAATFGPESTIHLPVPFPVDDEMTYDDVKTLLEADYPTTDLVFVKDHAAAVTGRYDKLPTGYTHAFIIRNPEKTVSSNMRLSERTGITTDQFVQISTTGVQGSGFGDLVKLAEHLESWLGKPPVILDADDLQRDPEKMLRAFCKALDLPFRESLLKWEPITEIPWNNSKAMLTLHRANGAYENALNSSGWIVTDPKPVDLSGLPQVLRELVDEARPFYETLHGKRLKQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU64</accession>
    <name>A0A914BU64_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079407.1">
        <property type="nucleotide sequence ID" value="XM_038223479.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223479.1">
        <property type="protein sequence ID" value="XP_038079407.1"/>
        <property type="gene ID" value="LOC119746506"/>
    </dbReference>
    <dbReference type="GeneID" id="119746506"/>
    <dbReference type="OMA" id="RCEEMWA"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000163">
        <property type="entry name" value="Complement factor I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2005"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2037"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2128"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2179"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2225"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2259"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="189"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="350"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="21">
        <location>
            <begin position="518"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="757"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="907"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="1031"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="21">
        <location>
            <begin position="1179"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="22">
        <location>
            <begin position="2017"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2425"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1462"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1469"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1481"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1507"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1514"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1526"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1546"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1553"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1565"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1673"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1680"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1692"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1712"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1731"/>
            <end position="1746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2463" mass="276406" checksum="9219416EB7263E41" modified="2023-02-22" version="1">MLEMYPERKGSQHYDLFTRLDTVCDAYEENSYPASCPLPLGVASGDVTNAQLRASSYMDENHTAGHARIGNPTSWRPLPQDQDPWLEIDFLERMLITGLLVQGGGKEHSWVKSFTLRFSNDLSAFWPYDEYKRLEIKSIVIKANGEPGCVKPIYLNPPIKARYLEINPQESYGGVALRLEVLGCRDNDCDFAAGIARGDIHNAEITASSSVGDEKGIHGPANARLNPFGVPRTGWIPSMSDSEPWLQVYLPSVYLITGVVTQGCGNLDRWTARYTIRYSADRSLEDLVDYRRLGHVQVFVGNNDRNTLKRNNLDPPIRAEVFRIYPQTSPDVHVDSCLRFELLGCKYRACGSRLGMESELISSSQITESSEYVGQDGDVGRLHHIACWKPNGMGNNHWIQVDLLELYTITGLITQGGYNNAFLGDQEVFYWPDSYRVLYTSWKDDSEWRTYFNLEGDVMDFPSYPDPHTEMRQDFDRPFITRTIRLIPRSWRGYCLRMEILGCRLSEGQVCGEASLLHDGFCVGSVNTQSSGACDAIFAEASQPLTINSLATQQWLGLKRDDIKVNDRHYQYKVGLKTELEGEVFTWADGTPMTYNNFRWPTNITDNSTEWCVYIDMNDDLRWREFKCMNDAVPRATICQLDVDECTTSGHLCSHTCSNFPGGFQCLCPRGYRLNGMDDIACTTLCKDKPPGQVFQNTSTDCLSDPYGLGCLDLTIPDIDIGWPDFSDQQWPEESYDHVSGSALSTVPTFPLLESTCNRDVADVRCEEMWARNVNLEYVYSKHGYIHSLSFPPWYNQASTCQINIQLPPGNFIRLEIHEMVLRRKPRTARCIDVLNVTDHLTPHHSMSRGSFCGDLRDLVVTCRSNNVTLRLDIGAIGQDMPKKLGFMASYSMTDCTGSTAGCDPGCGKKDVLTSSKGNFSTTDFPSELPPFSICAWNISLPAGSYIALNFSEFLIAEDEDSSECVDFVQIFLSDDSGPYEDAPAGQPMCGSTPSFIVSNSSSIQVVFRTGLDSKSLGFIAEYESTDIPGCGIGFYSGEGIQRCDMPEAAIASVNYPRHYLPGTSSVWHITTQTGTYIELEFVTFDVPDPFGISSFVQINDGAPDDRGSMLLAKLTNRRPPRGPIRSSFNEMTVRFRGDGSVTGNGFYAEYRAAVFVPKVDLYPSSTNNNICQSDWRYYNGQCYAFREANHSIRWTDAQRLCAAEGANLVSINDFAEMNFIHRLMTSDWLTNNFNTYIGLRYHHQRQQHRWQDESPMSYADWYIPRRIEHGLMTTPSLMMNSAPQPDGGALERCSQIILRNLHSTSHWHDVPCASKNSNQFICEKSSYRGHLPLTSGESLEQLSNAALCDDKWTLVHGHYCVKLLLNRSTTFLNRCPANSRLATAVYPNIAEKLPYLIEYVWGQDPSADMRFLIGPRGEGADQAYDVITCVDGHWRKVHERVARGVDGAICATEATVEASGCPTNMFTCGSGECLHRVFVCDHRSDCLDNSDEDSCSNDVEIADSVCTNTSFRCGSGECISLSFYCDFYPHCQDTSDETNCSIVTCTDLEFRCSSGQCINKELHCNLVEDCVDGSDEENCAAVLGGFQCYDGAWLPDHTHCDGTKDCPGNNREDEPNTDCVFFQCNSDPDLIQCNNGACVDRRHICFYDFDQFGYQTGCRDVTHLRFCDDFECSNNTFKCPGSYCIPLHRRCDDTKDCPGGEDEIGCSNHTCAGHYRCHDSRVCVTKSHVCDGIKECPSGDDELFCETKCPAGCSCTGLSYACTGVSWSDVTANLIPRNVRKLELRGVLAVTRRRREVLLNNNVSVEYTLFLPLVELQQLAELDLSGNGIDVLTPGMFTKQNNLYKLVLADNNIRKLENGTFEGLRRLQFLNLTGNPLAEIASGAFLDVVMLPVLDLGQLKLRHLQPGVFKGLDTLEALNVRDNPLTAVDSGAFYGLKVTHTLDIRGTDIAKVDPEMFEGLDSLQTLYADKYLFCCLLRDIDTCEAPMDELSSCEDLMRNPILRVFIWILGFSALVGNAFVIVWRSRSKDREQSRKIQTFLILNLAVADLLMGLYMIVIASADLHYRSDYMIHAQEWQESIVCQMAGFISVLSSESSVFLLVLITTDRFLGVVFPFSRWRLHTKSSRYAVACLWFLAFFLSLLPVVLRPAFGDRFYGRSSVCLALPFTRTKLPGWEYSVVLFLGVNLLGFLVIFICYFSMYIAIKRASKQCTRKRENMEEIKMATKMGIIVGTDFFCWMPIIIMGLLSVSGTAIIPQEMYAWAAVFMLPVNSAANPYLYTISSLDRKRKKARTSTSSPTWKTECTRDVSVDFEMVKYAKGDGSSKDKDNPSLMATVYAEQLENRVLPFMGRRIHSFMLRQYIAQAKTPLAVSVVAAIENDLRRALEFLHKNGIAHGKIDEDFVAIEKEKKDGRVAFLVMRGEPLDADESSGSGNSSPVEEEVPLLRRDNRQLDELLARLRGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYU9</accession>
    <name>A0A913YYU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044572.1">
        <property type="nucleotide sequence ID" value="XM_038188644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188644.1">
        <property type="protein sequence ID" value="XP_038044572.1"/>
        <property type="gene ID" value="LOC119719263"/>
    </dbReference>
    <dbReference type="GeneID" id="119719263"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="37327" checksum="4E9D24E5F21F4473" modified="2023-02-22" version="1">MRAPYHYPCYPSFWHTSSTSRLCTQSKKWRLVLHSFPNDTRQTVGFHLFSRFSIGPTENKELHSQDSNQPATTMRAFYPLVLASQVAVVLVLILAGYWTGHYLGGFAWDGSAKEFNLHPLLMILGLVFFYGDAILMFRIFRKENKTVVKVIHMLMQSIAIICGIIALKAVFRFHNKAGIPNMYTLHSWVGLPVFVLFCLQYIGGFVSFFFPKLNETRRAAVLPYHKFFGVTLLGLVCVTALTGINNKLFFAMPGGEGKDKYSSLPSQAYVGNFLGLAIVIYAVFVGFLVTFDEYKREQEAPNPEKLPLTTAEMKQFQTMDPADPSAGEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0B4</accession>
    <name>A0A913Z0B4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045263.1">
        <property type="nucleotide sequence ID" value="XM_038189335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189335.1">
        <property type="protein sequence ID" value="XP_038045263.1"/>
        <property type="gene ID" value="LOC119719836"/>
    </dbReference>
    <dbReference type="GeneID" id="119719836"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037091298" evidence="2">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="115"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="269" mass="30450" checksum="C172E6991EA02141" modified="2023-02-22" version="1">MNFPIYHPRHCRLVWCLVLFVVCVVQSGAGSNLPTVKSSDFTAVSQFNSTVKYRVIRSSQRASYLRCAAACLKEEYCEYFSYTKDTRRCELSDDSIVSVNEEKLKYFKRNGDSPCSVEGPLGMEDGRIPDESITASSFYRNLPTHAPPRARLHTQGLAAAWCDDGSEDSPWIQVDFNGTVTITGLITQGRGDRYNQWVTEHQVSYSDDAQSWDQVTDAFGTQIKFAGNSDRNTMVTARFPLALRTRILHIHPTAWNKHCSMRFEVIGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3D5</accession>
    <name>A0A913Z3D5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045220.1">
        <property type="nucleotide sequence ID" value="XM_038189292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3D5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189292.1">
        <property type="protein sequence ID" value="XP_038045220.1"/>
        <property type="gene ID" value="LOC119719802"/>
    </dbReference>
    <dbReference type="GeneID" id="119719802"/>
    <dbReference type="OMA" id="HRSELPY"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="497" mass="56398" checksum="092B14DB6A038D3C" modified="2023-02-22" version="1">MVYSSILYSFLDLRTVLVAVTVFLVLSWWLRRPRNLPPGPWGWPLIGSLPTMALAPGEPHEVFLRMSKRYGPIFTLDILGQRLVLVHGYEAIREAFQHPSLSDRPELHSVKEMLNGSEGVAAASGEIWKEQRKLSLNVFKDFGVGKSSFEDQIATEAGHLMQEIHKFGGKAFNPGTLFMTAVSDIIAVVVFGKRFEYDDPEFQRVLASIRRNLDLIGAGAAMQFLPVTKYLGFLPSMREMRQNIILVVNFTKEIIKRHLEEFDPDDKRDFMDMYIGEMKEKERQNVDTILSLDNLVSVINDLFVAGTDTTATTLRWGLLYMVLNPDIQQRVQQEIDAVVGRNRLPRMSHRSELPYTEAVILEMQRIGNIVPLGVPHRASEDTSLMGYTIPKDTFVIANHWALNLDPKLFPEPHRFNPERFLNSAGEVVKPEELIPFSTGRRVCLGEQLAKMELFIFFTYLLHQFTFKKPEGSPPLSLKGILGITLAPAPYEVCAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4N0</accession>
    <name>A0A913Z4N0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046724.1">
        <property type="nucleotide sequence ID" value="XM_038190796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4N0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190796.1">
        <property type="protein sequence ID" value="XP_038046724.1"/>
        <property type="gene ID" value="LOC119720930"/>
    </dbReference>
    <dbReference type="GeneID" id="119720930"/>
    <dbReference type="OrthoDB" id="6123456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="742"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="794"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120773" checksum="0C2A884C81CFEC0B" modified="2023-02-22" version="1">MASSGNTNTPECLMCKSPVENTDNSWRRYSLRLSGPSLEQFEGQDGFLCSSCKSKHLQQTASQTQTGQAKKRPSFSFYSTQKGRKKPKYSVPHSKVNTQSKGFLSRCKLIQYLSKAIKANQYAQAIKAILNHSKRSRQAFCTVASTAVRQEIRRCALKTLESKPVTPGNIATFKWGKVVEEAASHMPILVNVLKGALHRHQKMISTRPAVCMPDQRLGFILSLILYSHRARKFSFIQSCVSVKLKRQGCTSTVFKCLHALGVCVHLSKVTTSLAIDTAGTDYTKRQKQWQLNLSQQLESSATVVADNETQGTSPCGEKQAAVLNETHSLVADIDDDAASDMSVSADNNSDSDSVAESASAAVNADNSPSTSSKHDSSSKDTSQERKDQAPEVKQMLPAMHDSRRFEYLDPGYIIVCDSVLMQLATRRSLNEYKLQTSTFAVRNRVGFDQSSDYTVKRAGEIPLSCFLPKPSDWRGLKKRMCQILEHILKDHLPFLKQVECSAPKRHQHSDALSKKSEIASLGVIDENPYSTSGSVRMLESLHQFVPSYGDENLYPIVCFGDGLSVEKMVDAKRAKASGASAVDRLEGLVQCPQDFHRRGVLLQDTMDRFFKEDSAKETGTLFQINEDFNHCSVKQKVFENFSDVENLLNFCTHALSTVLAFKLAKLDGTTDTPADFPTLGRVQKKMWLTKFTQKMVDFIWPRFPTDDSLDKVHRQKKTQFCVDKKDDTFGDILADMVKDTKSCKCGESSDEGMIRCLNRKCGAWFHYSCANVDGPVEGDWWCSAECQASKSFIYCTCHRRTGKEDSMVQCEMQSRCTANEWYHVECIRGAEDLPDEWYCSPACKRLASFKPKGDRVHEYSRALLYEGLCHLAFRDAVREGDGPAILSHWRINTLQFWNNKHLKYFILAHNMLAGVSGFYPARVAHDMTWNRVANLTGQADGNIGLDLVNEIPTDEYWKMVSRTEDGYPEKEREQKSKPRDEFLHELESIFLKSRTTQTAQELQQLKFDQDVDSFASAYMHEGLFDYVPGRHNKSFPFFKHTVEVNCPELMGQNLVRLSQCMDRWRGVAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4T4</accession>
    <name>A0A913Z4T4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046737.1">
        <property type="nucleotide sequence ID" value="XM_038190809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4T4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190809.1">
        <property type="protein sequence ID" value="XP_038046737.1"/>
        <property type="gene ID" value="LOC119720943"/>
    </dbReference>
    <dbReference type="GeneID" id="119720943"/>
    <dbReference type="OMA" id="IFYITIR"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="251" mass="27293" checksum="288CD0FFE05907B6" modified="2023-02-22" version="1">MAEQASQAFQAIVGIVGICGNGLACMVIAKVRFMHTLTNAFIFNQVLIDLMGSLIALLLNVVPIPDPIPPGATGVFSALCYGIYLRYYEAGECVLNQVAHPQILGVCVFFATYCLPVSIMLVVYIHITVVLKKGAGRIQPGPAAAGPSTEGQGESLMRARRNTFKTLPIVCAAFIICWTPNQIFFFLFNLDVKVDFSSPIFYITIRMVALNSCLNPCIYAIKYKQFQKGLKVVFGKRGDRASIATASTGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4W3</accession>
    <name>A0A913Z4W3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046767.1">
        <property type="nucleotide sequence ID" value="XM_038190839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4W3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190839.1">
        <property type="protein sequence ID" value="XP_038046767.1"/>
        <property type="gene ID" value="LOC119720974"/>
    </dbReference>
    <dbReference type="GeneID" id="119720974"/>
    <dbReference type="OMA" id="MAIFFHC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5 6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="57034" checksum="B84E9580A3A87769" modified="2023-02-22" version="1">MSPVKQTVVMHSCFIYLAYLVVISAIILSSEGIPTKREAKRSNRSVTACVADSAVRLVRCGYTDGCIWAEFRCDDVIDCDDGSDESEATCRGGSACDESQAPACPSHSTCRSISASEIRLAHHVCDCVTPFTGANCTEMRTTTVQQAVTEATKKQGEYSSILATESTSSTMTSESQAFTTQGTTSDTHSADSSTSATKSQNTTPSDFTTGFDTTHSPGVSTVAIEKTSSPIAEDMTVATQSTTATITDQEVNNPGSLTTRHQSDPTTDFVTPNDATNTGDANTSNTATVSTASGTSSEFPSTESTQRSTVDKVPPTGVGATDNPTEPVPRQSTVIPTPGTTAAIDGHGHATQTVDSSSTPHPKRPPNNGSNDSRNQNPGTTPILVVVFGLITLIPMAIFFHCRVKRKGFKMLTSKAKKEDDKVESGDTQENSKPNHQRNSSISSIKLKENSTLLGNELPLDVNMNRPAPIPPAIVVTPPPDVTTESSLETQRAKKKKRHRKQQQTLPDTQFWFPDDGETPYFVTDNDPLPVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6P9</accession>
    <name>A0A913Z6P9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046498.1">
        <property type="nucleotide sequence ID" value="XM_038190570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046499.1">
        <property type="nucleotide sequence ID" value="XM_038190571.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046500.1">
        <property type="nucleotide sequence ID" value="XM_038190572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190570.1">
        <property type="protein sequence ID" value="XP_038046498.1"/>
        <property type="gene ID" value="LOC119720743"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190571.1">
        <property type="protein sequence ID" value="XP_038046499.1"/>
        <property type="gene ID" value="LOC119720743"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190572.1">
        <property type="protein sequence ID" value="XP_038046500.1"/>
        <property type="gene ID" value="LOC119720743"/>
    </dbReference>
    <dbReference type="GeneID" id="119720743"/>
    <dbReference type="OMA" id="QSHAMIP"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="304" mass="34706" checksum="99F1CAF2564D2132" modified="2023-02-22" version="1">MATSEKAPSSENQVRLLIWTVPRSLSTVLSKCLSFVENTKVFFEMYESIFIAPGVKTEDEMANMSEEEQKFLLALREKAHGISAGVDASQCTFQGVKEQLEEAHTGKKFIFSKDFAYAVMDRLESIPKGFRHLFLIRHPLKVFPSWKRSLLPFVPYLSLADDYRLDDLTCFPKGFGYKEVYELFEHVKKELDPEAIIIDADDLLKDPKGILSAVFNDIGLPFDEKILNWEAGDAVIEQWIIPRLYVQVDQLVGFYKNALDSTCFLKPKPLPDRSSLSPDLLPFVDASMPYYQNMYSQRLSASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7J1</accession>
    <name>A0A913Z7J1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047654.1">
        <property type="nucleotide sequence ID" value="XM_038191726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7J1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191726.1">
        <property type="protein sequence ID" value="XP_038047654.1"/>
        <property type="gene ID" value="LOC119721763"/>
    </dbReference>
    <dbReference type="GeneID" id="119721763"/>
    <dbReference type="OMA" id="WDNLSSY"/>
    <dbReference type="OrthoDB" id="10624635at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113578" checksum="2C98B5D9E6C46051" modified="2023-02-22" version="1">MGKVDYSKAVSFSYNPSAGSTADDEEDEDLVKERERREESLRRAAIKAAEDRRKRAARGRGRGRGRGRGGSQGSRPPPPRQQQAQPLESIEELRETPAVSERMTSAASVVPSARGRGRGRGRGRGRGRIERPPTVQSTRPITSQSNRSVTSQSNRPVTSQSNRPETSQRPGTTKSVRPVTPQREERPPSVKPEKPKEEEKPKEKEPEKEKTEEEQKPAEPAEPKKQLKFTTAVKVRMFMKSFFKKKQEQAAPEPEPEKKEEEDNKEEEPKAEDKPAEEVDEQPAVAAKEEEKEDEKEEQKEEEPKVEETKEEENEDANKSPSPTKDEEVKQPEPEEKTPTPEPEPEPEPEPEPKASSPAQNKEEEEDGAAATARPESVKEEPKEEPKEEPKEEEKEEKPEPEKEPELTEEEKEKARNVLGTLFGRRAPAVQVPSESMRASRVSLRSNSTVDEEEKPKKGFFGKLFGKKKPNDDAAMRASRVSLMSNSSPREASSSMSKSVISVKQAEETGAAPPEKKETVTPPKAKSPTPSPPEETPRKEPQQAAKPDPDTGSNRPVIIINASANDGSLQRSIVQALTGKPLPETEEQHPQPPQQQQQQQQQQQQPAVPQPPAFPPNTAYTGLSPQMVPYPMFQPPPFYGPPNPYFYPQMPPAYGGYPPYTMPMSMPPVNNPVIPYQQNPTFQQPAPPHQQPAPPQQPVIQPTNQNAYPQNYNNQPIASQNVRAHAVQPQPVGQSSLGIVEKLDAALKEERRRPPVSENLFDDSDSDDNFYNTEQRKIRRRKRTGKEQKRLERERKLLEEEEREKEEEARRKAKPKTPVPEVDLAGLLSLIETGEEPPEPVENEPAGAGDESRPESRTSVSDRGTVTPNAGNGDDDELNRLLAQLGGAPSTSPKDNPRKSAKKRKKSAAKPEPDLARESTLLALLKDEQRQQQNNSAGKNRRRSIAGFASPTRLDTDKRNSVPNLGLQPMGRPGEVAGLPRPLGQPSDVNGNPVPVNTRSAERLLHEAQKQLMSLKQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9Q1</accession>
    <name>A0A913Z9Q1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047736.1">
        <property type="nucleotide sequence ID" value="XM_038191808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9Q1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191808.1">
        <property type="protein sequence ID" value="XP_038047736.1"/>
        <property type="gene ID" value="LOC119721874"/>
    </dbReference>
    <dbReference type="GeneID" id="119721874"/>
    <dbReference type="OMA" id="CEGCPGQ"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF21">
        <property type="entry name" value="NUCLEOTIDE BINDING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33449" checksum="E6A85138E46085B4" modified="2023-02-22" version="1">METQKESDAAVAVGCPSETSLAGRADVCKGCPGQSLCQQQGGSDPDQEMIDLRMNAIKHKILVLSGKGGVGKSSLACTLSMALAKLHPNRVGLVDVDICGPSCPQLMAVKAQTVVNTQWGWTPLKSPLGNVKVMSIGSLLQQTDSAVVWRGPRKTQLIKRFLKDTFWGRLDYLVFDTPPGTSDEHLTVVKALKNVNPEGAVIVTTSQLVAMATVRKEISFCRKMGLTILGVVENMSGFVCPCCQEETNLFPTGGVEALAEEFNLRYLGKIPLDPSLTSCCEAGQSILEEYPDSSATKALMGLAKTLEACLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAX6</accession>
    <name>A0A913ZAX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048181.1">
        <property type="nucleotide sequence ID" value="XM_038192253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192253.1">
        <property type="protein sequence ID" value="XP_038048181.1"/>
        <property type="gene ID" value="LOC119722208"/>
    </dbReference>
    <dbReference type="GeneID" id="119722208"/>
    <dbReference type="OMA" id="ASAYHIR"/>
    <dbReference type="OrthoDB" id="9902777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="42793" checksum="371F51E15C2A4056" modified="2023-02-22" version="1">MGAGITSVECSEQDTVNISQEAVSSWLYTPLDVSIKTIVLPIIWCLGIITNLTFLFVIVRVPKLRSDTNIYLAHLSLADLLYSSMASAYHIRSYTASVVAFHDPFVNSAQCVSFFTVMNTGYFASIALVTMVSFERFLALCHPIKHLKIRGRRRTRRMIAICWLVGFLFSASTSPDILVLNVRCLQWPDVDAFLDYPSSYLYCGPVSPRVNYFIPPLLNLPWIMAMVANVSMYVRILQMLNKRTSNQNITVNTDHDATRIRNHVAKMLVANGTVFFLCQAPYRIFSLSRWICLLAQIPDPFRAALGSEITWISLVPQYINAMVNPLIYGAVNPAYRSAIRVAFKCKGQARRQNASLSVMRAPKQNNTTALAIDENIETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAZ6</accession>
    <name>A0A913ZAZ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048953.1">
        <property type="nucleotide sequence ID" value="XM_038193025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193025.1">
        <property type="protein sequence ID" value="XP_038048953.1"/>
        <property type="gene ID" value="LOC119722718"/>
    </dbReference>
    <dbReference type="GeneID" id="119722718"/>
    <dbReference type="OrthoDB" id="10135721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="14334" checksum="18EAD8F9BA1C4D7A" modified="2023-02-22" version="1">MGQTEIPPDWSQSRQDESNEDWETSSRIDLQILPEHHQGSITCRAMFPDGGTVFREMTVKLIADDKHEVLLLAILIPTAVAVFIVGVIATVCKLRSNIKRERARSYRGKEAAIENYSGKKLPTISVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBN7</accession>
    <name>A0A913ZBN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049198.1">
        <property type="nucleotide sequence ID" value="XM_038193270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193270.1">
        <property type="protein sequence ID" value="XP_038049198.1"/>
        <property type="gene ID" value="LOC119722873"/>
    </dbReference>
    <dbReference type="GeneID" id="119722873"/>
    <dbReference type="OMA" id="NEMCSKR"/>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000316">
        <property type="entry name" value="Putative neuron navigator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="459"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="797" mass="89184" checksum="243654FB0783CAC2" modified="2023-02-22" version="1">MPASSGDMDLDFNDLNLDDGTMAHVVAAFEQSLSNMTNRLQQLTCDADQKDSELQELRTKIELLKYTQQAAVAGEHQRNGDPAALLRKQSFGKDSNVFPEVRISRQLSTDSMSSLASMTSMSSFGSAVTDSEVTDGKKNLKKKKHWLRSSFRAAFSRKKKNGTSTDTEDLESNSSFQSGGYPANQQLKTSASTSAIYDAEKSQETINDLKRKLREKESKLTDVKLEALSSQHQLDQMKESMSKMKNEMSTLKQENDRLQRQVVAHRSLDASSSQASLNSLGSSKRLSRDSLDRHRLSMNSDHGSLDILLDDNSGMTNNSQRIIVTVAVNSLPEAVKQAEHVLPKQQEVFIGTIGISSKTNWDTLDSVVKRIFKEYVLRIDPVTNVGLSAESVHSYIVGEIIRTKDSDPPELLPCGYLVGDNTSIQIHVKCVQQNSCDRLVFETLIPKPILQRYISLLLEHRRIILCGPSGTGKTFLAQRLADHIVQRGGKEPSESTIAVFNVDHKSSKELKQYLTNVADQCETNSVDLPSVIILDNLHHVGSLGDIFNGFLSYKYHKCPFIIGTMNQATCSSTNLQLHHNFRWVLCANHMEPVKGFLGRFLRRKLVETEIRENTRNNDLNKIIDWIPKVWQHLNKFLESHSSSDVTIGPRLFLSCPVDLAGSQVWFTDLWNYSIVPYLLEAVREGLQLYGRKAAWEDPAEWVIDSYPWQPTSSQDWPSLLRLRPEDVGFDGYTMHTGIKGQQSGQSDAEGDPLFNMLMRLQEAANLSGAQSCDSDTNSIDSVGLSTEDIQKTVEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD54</accession>
    <name>A0A913ZD54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038048865.1">
        <property type="nucleotide sequence ID" value="XM_038192937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192937.1">
        <property type="protein sequence ID" value="XP_038048865.1"/>
        <property type="gene ID" value="LOC119722689"/>
    </dbReference>
    <dbReference type="GeneID" id="119722689"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000152">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.830:FF:000002">
        <property type="entry name" value="Isoleucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000009">
        <property type="entry name" value="Isoleucyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="68"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="721"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="975" mass="110269" checksum="4EAEFB660A6EFF4E" modified="2023-02-22" version="1">MLRICWKTWGSPLKLKNCIMVRGKRYFSSKKYADTLNLPKTTFELWGAGKREEDIRRVCGFSELYSWQRKQETGKAFCLHDGPPYANGDPHIGHALNKILKDVINRYKLLRGYRVHYKPGWDCHGLPIELKALSEKEEDFRKLSPPEIRRKARNFAAKAIDRQMEAFKKWGIMAEWESGCYYTFDKEYEASQLRIFHQMYQKGFIYRDLKPVNWSPSSRTALAEAELEYNPNHVSPSIYVKFPVSKLPGKLAEYSTNLHAAIWTTTPWTIPANEAICYMPAKDYSVVRCAETGENLLLAAERVEEMAEILGKKFERIVSFGGSELEGGSCFHPTISGKTVPLLPAAHVKMSMGTGLVHTAPAHGPEDYGIAVQFNLPLHCTVDEDGIFSPEVGQDLAGKNVLTEANDIVIEMLRCNGSLLKQSNYVHSYPYDWRTKQPIIIRPSKQWFINTGAIKDRALECLENVEMLPSHALNSMRTYLDGRTFWCISRQRVWGVPIPVFYNKETDEPLLTSESVSHVTSLIEKHGSDCWWNLPVEELLPDSLIPKSGSKSKDFVKGEDILDIWFDSGSSWSHVLKDSDEQADLYLEGEDQYGAWFQTSLLTSVAVKDRAPYRSLLVHGFTLDGEGRKMSKSLGNVVDPDVVVSGGKNKKTDPVYGADVLRWRLAESSWLTRVQVGPELFAMTNQNILKIRNTIRYFLGNLYDFDPTSDLRPHADLLPIDKYMLHLLHDYGSKVATAYDSYEFGEITAKVTELIHGKISAFYLDTMKDRLYCEAYDSLERRSCQSVLHHLLEVIVRSIAPITPHLAEEAFMHRPDAVSVFKTGWFHCDSSWHQPELAAVLGALCSVRETFLAAIHAPRSREYDVTVCTNDIQLLGYLQALQEETTSSTSHLSELMMASFTTVAMEMERSPTEGSIQVAGSVGVPSTNGVTSSAEYSLLIQPASHHHCKRCRKRTAEMPNQPCSRCLLAMSGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEC2</accession>
    <name>A0A913ZEC2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050136.1">
        <property type="nucleotide sequence ID" value="XM_038194208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050137.1">
        <property type="nucleotide sequence ID" value="XM_038194209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEC2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194208.1">
        <property type="protein sequence ID" value="XP_038050136.1"/>
        <property type="gene ID" value="LOC119723512"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194209.1">
        <property type="protein sequence ID" value="XP_038050137.1"/>
        <property type="gene ID" value="LOC119723512"/>
    </dbReference>
    <dbReference type="GeneID" id="119723512"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="425" mass="49044" checksum="37AF2A9DEFE0DA82" modified="2023-02-22" version="1">MKTTTFQHHFISEDGELRSAAMGKYVYMYTSRPVITVKSKETTPNVGRISVLLGMVLVVTCTTLAFICSPFSPVNQMQVLQHAHVPRSHDSGEAEFGQIAPAYEPNPKNILYIFTGRWRYLRINFAYIYRSLRQNGGVLDRVYYVMIQYDDQTLSKLTELTDSANKYLGEKVFELKIRNPNEDTTRLPKDVFPQVAYEILAEIVKYPERKYFKMDDDIVYIHPGAFRQLIEQQNTSECFLHFANIGGANWRSSYIHQEMGVFDDKEINPNNLRFEFNPKGNPRCGFKSAECAQLALRGFLHHYENKSLDRFQFDGRYPTTERGRYNINLLLLDVNIINFNAMLDSTPIGNDYEFWLTQKYSSKVKNPNCIVGGAFVVHFAYSVNEKEIRKQNFAEKFETIAFNDLVKFLPGEFQNILALNATSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEK0</accession>
    <name>A0A913ZEK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049375.1">
        <property type="nucleotide sequence ID" value="XM_038193447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193447.1">
        <property type="protein sequence ID" value="XP_038049375.1"/>
        <property type="gene ID" value="LOC119722997"/>
    </dbReference>
    <dbReference type="GeneID" id="119722997"/>
    <dbReference type="OMA" id="NMSTIRC"/>
    <dbReference type="OrthoDB" id="10045021at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="492" mass="55503" checksum="6DD47E87FACFD22B" modified="2023-02-22" version="1">MTDFWTENYWVAILIGVGGLILLILILIAAIFCYRRCSRYDYTPLRDYMSLPAKLQKEKKMERDTVRETALLNCQFYLRAHAGKYTFSEHLPDMGSRVDKHWFLVRYASQNKDVLLSTCNKATNCTIPFTSNTHKVLRELLKCVKHPYLWPVLDIDLLEEQDMEVLIQSYNSRGSLKDYIYHEKPHQDWDNKYGVKGRGLALKEIQLFGRQVLEALLYLQDGGFPQHCHVQAGNIILQKGTCKLSGYENILLGHTSRLFPVLCKKLKEIPEVFDSLAFGHLLYEMGAGSALEDTVAIPERSHFNKLKHQQVVEILEFIFDANGAYPSLREIAEHDFFQNVRLKELEKKPPTEIHLTSAMKNLLKTVKKGRILKTQSIRRGTPSKHTRSKRRSSGSSLKSNEAETVLSQEPVNNGTLPSASDGYASSRVTPIPAAITPTPPQAAPLAPPPPAVAVVTPRAQPNLPSISEERSSLLSDIRKGLTLRPTGTSQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF06</accession>
    <name>A0A913ZF06_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049646.1">
        <property type="nucleotide sequence ID" value="XM_038193718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193718.1">
        <property type="protein sequence ID" value="XP_038049646.1"/>
        <property type="gene ID" value="LOC119723160"/>
    </dbReference>
    <dbReference type="GeneID" id="119723160"/>
    <dbReference type="OMA" id="VAGQCEL"/>
    <dbReference type="OrthoDB" id="10146923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="228" mass="25719" checksum="BC8194128B7471CC" modified="2023-02-22" version="1">MIEEQGVVIELNMESCILLPVISMYLLLLPGSAWSLCCPTCSLRSVDPLNAQQIEQIRSNQELIQQIKLNPLLLHNRYYQRSVVTLTKRQRGQILRNLPDLFLSEEDFRKSLMTRGRVTVEESPQGMYSRQKRQTTATRVCEPLAGVDALQLALNLDGQVVEIIQMPDQDLNQWILEESCDDLESSPPAPLACGLVDRVVPGVFVTLSEPFIFDHAYVVVQSCATVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGE6</accession>
    <name>A0A913ZGE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Multidrug resistance-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050083.1">
        <property type="nucleotide sequence ID" value="XM_038194155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050084.1">
        <property type="nucleotide sequence ID" value="XM_038194156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050085.1">
        <property type="nucleotide sequence ID" value="XM_038194157.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194155.1">
        <property type="protein sequence ID" value="XP_038050083.1"/>
        <property type="gene ID" value="LOC119723480"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194156.1">
        <property type="protein sequence ID" value="XP_038050084.1"/>
        <property type="gene ID" value="LOC119723480"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194157.1">
        <property type="protein sequence ID" value="XP_038050085.1"/>
        <property type="gene ID" value="LOC119723480"/>
    </dbReference>
    <dbReference type="GeneID" id="119723480"/>
    <dbReference type="OMA" id="IRCIRVI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000012">
        <property type="entry name" value="ATP binding cassette subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000015">
        <property type="entry name" value="multidrug resistance-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002835">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="166"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="580"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="890"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1229"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="809"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1475" mass="163227" checksum="FBAD5912620FD712" modified="2023-02-22" version="1">MGEDTPDVEFSDGHHGAAGNATDYMTAFPVDNAGLADIRTDEDIMLKPEDGTQVAYRRRKGIKKYKQSMKMLVPIRPKPKSGPFIPLDHSGLFAYLTLSWLTPMFKKAVKRQLEFSDFWKFSDNDSGYRNGERFQLLWEEELKKKGREKASLGKVCLRFVRTRHIFAVLCLLLSVACIFVITSVLVQRLLMYTEAEEQDLGYGLGIVFAILGLNILRVIFDVTFWLTIFRTATRLRNGLLSMTFKKIARLRSLQDKTVGEIVNICTNDSQRLFDAMSIGNLLISSCFLLVSCITAVSIIVGPAALIGVLGTFMVITPMQLVMGRVIAKLRQRGILITDERVQKMSEVLTYVKLIKMYAWEAPFAKKVAAIRATERTILERVAYIISFSLSLIPLVPNIATVLTIVIHIGFGNDITAAEAFTLIAVLNSMRSVLGPTPFAMRVLAESAIGLRRIKSVLDMTDIPPLPQLPPDDQCTVVIKNASFGWDKVKSVAGGKKEDEDNDKEDEQKNAANGAAVDGVTVLVEDGKPGNGIENGGPSIAPDSPSKDDSEAFEDVPLKKSPNTNNNANASSNGKESGGARQGSEVTGGDDPTDPDDLKVKTLFDIDLSLEKGRLTGVCGAVGSGKSSLISAILGQMHTMEGSCAVSGSFAYAAQEPWIFNATLQENILFGAEMDEGRYEKAIAACCLTQDLEILTDGDMTEIGERGINLSGGQKQRVSLARAVYADRDVYLLDDPLSAVDAHVGLHIFNECIKGALKGKTVLFVTHQLQYLKDCDSILTMVDGRIAERGTHTELMDDEGEYARLISKHHAKAESDENDKEEAELEVEEVGKLQRSHSQMSSKSVGSNASEKSDREEDGKLVQDEDRSANAVGWVTYKGYMKAAGGYHMILLAFLTYILVIGSLNFNNWWLSFWLNQGNGTQIQVNGTNPGDPPTMVTVGSIADHPDLNFYMMIYGVTLAATLVFGGLKSRVLMKILLQASSTMHDTVFVKVFRSPMSFFDTTPTGRVLNRFSKDLDEVDVQLPTNMEIFTQNSFLILFALITISIVFPYFLAVMVPIVFFFGLILYYYRRGVRAIKRIENVTRSPWFSHIMATVQGLSTIHAYGKTEEFINRFINLLDNNSQPYMIFRMASRWAGQRLEVLVIGASLVTNLFVVLTYGIVSPALAGLAVSYTIQITGLFQITILMASETEARFTSVERILSYTRILKSEAPPHIKETAPDKDWPQEGEIEFKNYKMRYRDNLPLVIKGINCRIKPKEKIGIVGRTGSGKSSLGVALFRLVEPSSGEIVIDKVSIATIGLNDLRSKLSIIPQDPVLFKGTVRYNLDPFEEYSDAKIWEALERTYMKDKISTLDNQLEAPVVEGGDNFSVGERQLMCMARALLRNSKILMLDEATAAIDTDTDSLIQTTIREAFSECTLLTIAHRLNTILDSDRVLVMDDGWIAEFDKPASLLANPDSKFFKMVEAAESQKHAVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHU8</accession>
    <name>A0A913ZHU8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 51</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051357.1">
        <property type="nucleotide sequence ID" value="XM_038195429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195429.1">
        <property type="protein sequence ID" value="XP_038051357.1"/>
        <property type="gene ID" value="LOC119724398"/>
    </dbReference>
    <dbReference type="GeneID" id="119724398"/>
    <dbReference type="OMA" id="GCAFNTG"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="55"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37721" checksum="698DCCF833C92D75" modified="2023-02-22" version="1">MGNDTAHRSECTQDSHPRAPFTNSSLHLPVSLAPPNTFITAGSQLLTEDVTCTDKPDWVEFTGGAGAAFINIIVTFPVNKIIFRQQLHSIRVHKALSQLKKEGARHLYRGVLPPLLQRMSGLSLMFGLYDQYSRILIRHCSDCPLIVAKVSAALLSGTTEAILVPFERVQTLLQDHRHMKNFDNTFQVFHRLRHYGLREYYRGLTPILLRNGPSNAIFFTMREKLQTFTPKDASRVQKISSDFVNGAILGASLSTIWFPVNVIKTKMQSQVGGEFVSAWRTLHIVYNERGRRWRAMFRGVHLNFSRALISWGIINASYGILTSTLHELRGSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ74</accession>
    <name>A0A913ZJ74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051105.1">
        <property type="nucleotide sequence ID" value="XM_038195177.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195177.1">
        <property type="protein sequence ID" value="XP_038051105.1"/>
        <property type="gene ID" value="LOC119724226"/>
    </dbReference>
    <dbReference type="GeneID" id="119724226"/>
    <dbReference type="OMA" id="MWRWGVV"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036941374" description="Collagen IV NC1 domain-containing protein" evidence="10">
        <location>
            <begin position="47"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1545"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="667"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1419"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1346"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1523"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1767" mass="176233" checksum="0944FEA9DA74F408" modified="2023-02-22" version="1">MRLDVFAALGRTLGGQNSAPRTLTSTMWRWGVVAVLLLAFVGSSIAQKADCGATCKACNCKGRQGQRGTPGQIGPEGDRGARGILGYQGVQGPKGDIGDPGAAGPRGQKGDRGMTGVPGFPGLNGYTGLPGPKGPYGNPGVAGCNGPKGEDGIPGIGGYGPRGPPGFNGPKGSKGEPAPYTPAIQGRRGDPGFDGPDGNPGQQGRNGYPGQQGDRGFKGFQGSRGFDGYQGPPGANSPGYKGPKGEPGAQGPKGRSASPFSNPPNIKGSPGTKGDRGETGAKGDVGMFGMQGPKGDPGPKGGKGFLGMKGEKGVLGIAGPRGPVGYTGLPGAPGFIGDRGFDGTRGQDGVPGYQGFRGDVGDDGPIGFKGDAGIPGEIGDGPVGPPGPDGDPGLQGHPGARGAVGDPGEEGLPGRLGEIGGPGPVGRPGLSRDGQQGDRGVGGIPGKQGFQGSPGEQGQKGQPGDKGAPGFPRAGPVGMDGAFGRVGERGRKGVVGAQGRPGPPGLTPLGEEIVGPIGETGPRGPKGVVGASGPQGPSGGKGFPGRPAGPCPRCPQGLKGQPGDIGFPGTDGRFGPDGERGPTGEKGANGEPGYLGRQGQPGFPGLRGPRGLKGDTGDRGTPGRSIPVRGYKGERGEQGLKGQIGEPGTQGIQSPFDLNQFRNMTQKGEMGEKGRKGGRGTDGAPGPAGEDGVDGERLDGPRGPKGVMGEDGRFGFLGPKGQKGEPAERVDIEEPIPGPRGEPGPQGAKGGRGPAGFQGQIGFPGPFGDMGIRGTKGGSGFPGVPSFPGPKGFPGPRGDKGLVGIQGEIGRQGRQGEPGNPGFPGRDGMRGDRGEDGQSGSVGPTGFPGDEGPQGIKGTNGFNGLPGQSGFPGFQGMNGERGDPGPFGPQGERGLKGATGIGFPGRQGSPGRDGPRGPQGPTGAEGPPGDRGVFGGIGSTGDNGEDGFPGERGQQGERGEKGFPGRAGRPGLFGARGEFGDPGLDGLPGNPGQKGNAGFPGFSGRPGEPGPQGLPGKDGLPGLIGETGDPGRTGQVGLFGDFGEPGDIGEPGEDGADGLIGPLGQDGRPGSPGFPGPIGNRGFSGITGMVGDKGGVGEQGRPGNLGLDGLTGEKGYRGLRGFRGVTGFEGDLGLIGRPGPRGPQGPAGQKGDSGVPGTPGLFGEVGPPGDPGSRGSKGIKGSSFNPNDIKEPGTGEKGAKGEKGDQGSRGLNGLRGTVGDRGPSGEPGNQGYDGYDGFDGIAGMRGDPGLPGLFGVEGLPGMPGEDGNPGIKGRQGLPGPQGPKGVIGFSGFSGFPGSAGTDGRPGERGPRGNKGFPGLPGVPGFPVFIAPAGEPGEDGPRGPDGPKGFVGQPGQPGFPGFSGLKGPKGEPGLTGLGSPPVLGPPGAKGIQGPTGVPGLKGRVGDIGFPGPVGELGPFGLKGYPGYPGRQGRPGLPGFNGPKGQPGDQPDAQKGVKGDSGDPGPFGIRGRPGRPGFAGVDGSVGLKGMKGDFGDPGEPGSIGPKGQFGPQGLRGDFGDPGPQGFKGGKGVGGEEGSPGPPPRPQGFIVVKHSQSRNIPRCDVGMTQLWTGYSLLYTEGNEKAQHQDLGLAGSCLPRFSTMPYVFCNFNEICNFAQRNDKSYWLATSEAIPMMPVEGNGIRPYISRCAVCETPTQVIAVHSQDTTLPDCPRNWRSLWIGFSFAMYTSAGADGGGSALASPGSCLEDFRATPFIECNGRGRCFFYRNTYSFWLTTVDADAMFRPQESQTLKAGSLRSRVSRCQVCQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKF5</accession>
    <name>A0A913ZKF5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052297.1">
        <property type="nucleotide sequence ID" value="XM_038196369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196369.1">
        <property type="protein sequence ID" value="XP_038052297.1"/>
        <property type="gene ID" value="LOC119725003"/>
    </dbReference>
    <dbReference type="GeneID" id="119725003"/>
    <dbReference type="OMA" id="NYPANAR"/>
    <dbReference type="OrthoDB" id="5804959at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036802178" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="150" mass="16889" checksum="420714166047D29A" modified="2023-02-22" version="1">MQTRRRHHQEWRIFFLIILANGALCDVPCGKSNITLSISTQTSETLTSPYYPNNYPANARCIWYITVDEGSTIAFRFSVFNTERKWDTLTIGNSHESSDGDSVIGLFSSSLTSLAVISNNHTAWMEFTSDSSVTKIGFEVKITQESYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL02</accession>
    <name>A0A913ZL02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052477.1">
        <property type="nucleotide sequence ID" value="XM_038196549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196549.1">
        <property type="protein sequence ID" value="XP_038052477.1"/>
        <property type="gene ID" value="LOC119725188"/>
    </dbReference>
    <dbReference type="GeneID" id="119725188"/>
    <dbReference type="CTD" id="114876"/>
    <dbReference type="OMA" id="HAESPHF"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000005">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF209">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="255"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113742" checksum="1FE3BEC5B16F395D" modified="2023-02-22" version="1">MDPDENALSDSSSEPTSPLLFSSNEERLLYASRHGDSQTVRQLLRQNNEGAIQLNIDCKGTTKANLGWSPLHLAAYFGHVEVATLLLSYNADFDIVNTNGDTPLHRAAFTGRLELVAALIQYGADVTIVNGEGHMARDIAHGDDIQKMLIATEQAQKLKLEQQLLASSAEGLLDHVQTLLFGPRPPNINCADVTGNTPLHCASYRDQHEVVMLLLQHGANPRLPNKKGHTPIDLAQSQHMKQLLNVKPVKVVQSVDKREGPLLKTRFTGSLKQYWVVLDRGILTYYRKRADAVAGIKRVGFRYLDHAEFKTSTTNSNAFAIQYSNNTVHTWLLDPECTKVSREDWLNALEDHRAYSDHYTMASTVDDDYDDVSEEFLPLGSIADSLKTAQARQRVLEQSAESFQKLVDRCLSKKAKDQASALEYMESLPEVRRQLAWLTDASKSLCSTLGQCLASMMQQEELRKVELSQALEKSRVLQDGLQALALEHHDLEQISRYSSFSGTFYDAKTEASCAGSPESLSDRASLELTGSLSDSDSFHSIMDGVTGSLDRLHVADPEGQRSDLKKDGPEEETKPMANGVTDIVIPGCSRTKLPAVMIRRDQFSLWTVLKQCIGKELSKITMPVVFNEPLSFLQRFCEYTEHCQLLYKAAMSDDPVERMKYVATFAMAAGASNLDRLSKPFNPLLGETYELVRDDMDMKIVLEQVSHHPPVSAFHCTSPYFEFHGSIYPKLKFWGKSLEVLPKGVVTVTIPKYNETYTWHNPSSCLHNLIVGKLWIEMYGLLEMTNHRTGHKCFLHFKPAGWFGKDLHKVEGYITNKNDEKIVMLFGKWTEYLYAMDPENYDGARKEEKKRHHRHGLGHGSGSPSDHVTYDMPLNPEGEEFNNAQLLWHNTARPDNSTQYYNFTLFAIRLNELTEQMKTHLPPTDARFRPDIRCMENGDIDSASDEKHRLEEKQRATRKHRSKSKETWSPLWFKLDINPNTGEQDWVLKGNYWDRKYTKCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMT4</accession>
    <name>A0A913ZMT4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052366.1">
        <property type="nucleotide sequence ID" value="XM_038196438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196438.1">
        <property type="protein sequence ID" value="XP_038052366.1"/>
        <property type="gene ID" value="LOC119725077"/>
    </dbReference>
    <dbReference type="GeneID" id="119725077"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="84"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="244" mass="27569" checksum="4CD504FCE7A16DA9" modified="2023-02-22" version="1">MGVVWAERVCYFGQEPDANQSGRLRWFMPGSKADRCACTSTRPGPVYMQPVHWSHPPFYTDTPMFTNDQEDIHDYFNCHDVLECSREGPFGMEDGRIPNESITASSVHPNRANFAPTRARLNLQVKGGAAAWCNVGHDETHPWIQLDLGSDATITGVITQGRGDHPDWVTEFKVAYSDDGQEWTDVIDNGSSTPMKFPGNSDQNTHVTTTFPKAFRAWFLRILPTQFHEYCCMRFEVLGCTINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPL7</accession>
    <name>A0A913ZPL7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053667.1">
        <property type="nucleotide sequence ID" value="XM_038197739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197739.1">
        <property type="protein sequence ID" value="XP_038053667.1"/>
        <property type="gene ID" value="LOC119726128"/>
    </dbReference>
    <dbReference type="GeneID" id="119726128"/>
    <dbReference type="OMA" id="NRIAIVY"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="739" mass="82399" checksum="FCFFD2E22A71510D" modified="2023-02-22" version="1">MGLTYLFLYGCIIAVCILVLSKICAGILSKVLSHLLKKDVSIDYIGFFSLKNVSVQLHKSSVVLDDIWISWRLFNPSQNYRMALHLGDVRVRAEMQNDQERTPQPERGEKSVKSGRKGSSFLNSSYFISGIRFLTKMMCLKVEALNIMLLNAMGTDSLLHVTIKNISLAGAALTEQVIATDLEVQQISLRMLRSANSDAGEQSHTAQASTSLKVSLQLDLILKKILGISVNVGSPRVSLLDGFMTQILPTFPRKTAPSDPQEHRELQQQKPFEEKLRAVIQKLPRDAKLQIDDIDCQVMIQSEQRRLTLTTKQLLVTADVDSDKLISCTKTKDLLLPGISCLLKLTDVQMNNMQSLKLLSLNDISVSLQLRETGVYSDLALRHCHVLYHDEEMMFWLTTIQEQIKQRKARQGIVIPTRPTIVSHPEPPKASGTSSLLQEFTLPFDLTLDLSDMSGHMTWPNAPDCAVTIATLKTGTRITSDSGSTPKKPLRYIRCNMQGDRIFCQVGDAVRTPNGVTMSSRHTWGTPLAINNIKMKVNFTPYSIDVDGAVNSLQLESCLELHSVVEHILKVTRGQEVKGQGSERQKVTVEAGLGPKHRTQRVNLRLSDFNAFVCSDLKERIMLRVDSVEVDSESEGNSTAVVMGTKLLVVTKDSKVIDCVAYMSLPEAILDVTLINLKYTAASKTLNAVIEETCCARWNTTNHMTMYHHIKEVALFGLKVKGLLPKRERVILSPDAQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ92</accession>
    <name>A0A913ZQ92_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053300.1">
        <property type="nucleotide sequence ID" value="XM_038197372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197372.1">
        <property type="protein sequence ID" value="XP_038053300.1"/>
        <property type="gene ID" value="LOC119725795"/>
    </dbReference>
    <dbReference type="GeneID" id="119725795"/>
    <dbReference type="OMA" id="WIHARSE"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF48">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="37085" checksum="563DF93AE4FDDD69" modified="2023-02-22" version="1">MLVLVCAAVAVFACLVVVLVLDRIYIDIEGKYVFITGCDSGFGNLLARNLDRRRGCHVIAACLTEEGAAKLKRVTSSRLTTLQLDVTSSESVRRARDAVQTIIPEGQGLWGLVNNAGIISPLGPYHWLNREDIVKVLQVNLVGAIEVTNTLYPLIRAARGRIVNVSSAVALFPSSGTIYTASKAAIEAFSDNIRCDMKQYGVSVHVIEPGAYQGTFSDTDAMKRRLNTAWERLPQEERDSFGGEIAREAMELLIIDALRMASPHLHEVTDAMEHALCSRFPWRRYLPGLDAKLFYKPMSLLPAFLADGVYNFLFGQALENKKKIVRKAKALEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRM6</accession>
    <name>A0A913ZRM6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054302.1">
        <property type="nucleotide sequence ID" value="XM_038198374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198374.1">
        <property type="protein sequence ID" value="XP_038054302.1"/>
        <property type="gene ID" value="LOC119726622"/>
    </dbReference>
    <dbReference type="GeneID" id="119726622"/>
    <dbReference type="OrthoDB" id="6506579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="575" mass="64409" checksum="CC128B4711FB9153" modified="2023-02-22" version="1">MYRSGRPQLRRPNTVRFNTRGIEDIVTPEEVYEAVKKELKSKDTMKCIAELNNKWYNVTLDNEADCERLANYGLVLNGLLVQCERASIANSVVAYVKAPYELSDQAVISALSAYGSVVNIKRQYHDFDSNVETGVRSCLIKNLMKPIPSYIRLGSFTLPIRHKGQLKTCKICEATDHFARDCPARGRCYVCGAYGHRASAHHDENSRKDRLEVESDEESRVNTPVLAIPGGSQDDRDSTTHYDTEDSIFDETQIEPLTLTKKYNLPTYRFKDGKKYCKKRKNQDTEEENVGESYRKITREEEEEMEQSNQQEPQTHGQTSRQDTQQTAPQIAQQTEQQTEQQTEQQTPPKTTSQTTLQTTPQSTPEIASQIAPQTALQTTSQIIQQTAPQTASQIAPQTIQQTATQTASQIVPQTTPQTAPRTAPQTAPETAPQTASQTAPQTEQQTALQIAPQIASQIATQITQQTVLHTIPETPLMTTTQAEPQTVSQNAPRLAPQTSQQTIKQIQSGQNASQDIIPSSQPTDNEDEDFVRYMRGGVERLRKKRTSWERKEKDQKASPSRGPRGRGKGKATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSE4</accession>
    <name>A0A913ZSE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sperm microtubule inner protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054095.1">
        <property type="nucleotide sequence ID" value="XM_038198167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198167.1">
        <property type="protein sequence ID" value="XP_038054095.1"/>
        <property type="gene ID" value="LOC119726464"/>
    </dbReference>
    <dbReference type="GeneID" id="119726464"/>
    <dbReference type="OMA" id="QYLKERM"/>
    <dbReference type="OrthoDB" id="410807at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054323">
        <property type="entry name" value="SPMIP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826:SF1">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22589">
        <property type="entry name" value="SPMIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sperm microtubule inner protein 1 C-terminal" evidence="1">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="20901" checksum="3B8DDD587801FBC9" modified="2023-02-22" version="1">MRELFDVQRQNFWTESIHKEAYTRLAWHEKYSKEFARESRQGIARKHRPNMVPKVAAAVKPPKPAEKSQSLAELAAKKEARKKDLAAIEDPDALLVEMRSVTPVVKDQLYKGFSKEGTGRYAYLQIRKLKKPESKYDFPITSSWEYGWRLDDVVKEFRAPAFGRSRIVKDSFYRTNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVY2</accession>
    <name>A0A913ZVY2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055674.1">
        <property type="nucleotide sequence ID" value="XM_038199746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199746.1">
        <property type="protein sequence ID" value="XP_038055674.1"/>
        <property type="gene ID" value="LOC119727716"/>
    </dbReference>
    <dbReference type="GeneID" id="119727716"/>
    <dbReference type="OMA" id="QQVMYCA"/>
    <dbReference type="OrthoDB" id="10384927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036848484" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="158" mass="17539" checksum="8363D48EC09B6590" modified="2023-02-22" version="1">MARFTMLAIVVLCLIVGNQGADDIYTDMEFYAKDLTCNDEQSYCQNCFTARARGKVFLHTFEYVTNPDKFELSQLEGDNEWKMAFVQEDQSETFHVCTTSNTDGAEGGVSQQLSVCMENNFPGVVAPEGCSKPVALASLSDKFANMKMSGQQVMYCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWB1</accession>
    <name>A0A913ZWB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055351.1">
        <property type="nucleotide sequence ID" value="XM_038199423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199423.1">
        <property type="protein sequence ID" value="XP_038055351.1"/>
        <property type="gene ID" value="LOC119727521"/>
    </dbReference>
    <dbReference type="GeneID" id="119727521"/>
    <dbReference type="OMA" id="IYDPDMF"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="81" mass="9260" checksum="24947088FAD90E74" modified="2023-02-22" version="1">MTVYHDEIEIEDFEYDEETETYHYPCPCGDRFEITKEELSQGEDVATCPSCSLIVKVIYDLEDFMEGEEVAAPSQKGLQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWJ4</accession>
    <name>A0A913ZWJ4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056023.1">
        <property type="nucleotide sequence ID" value="XM_038200095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWJ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200095.1">
        <property type="protein sequence ID" value="XP_038056023.1"/>
        <property type="gene ID" value="LOC119728015"/>
    </dbReference>
    <dbReference type="GeneID" id="119728015"/>
    <dbReference type="OMA" id="EATWRCI"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="71644" checksum="00BC99C6E9B6544F" modified="2023-02-22" version="1">MAEAAVKTVWKISQRHLECPICCCLFKDPKMLDCLHSFCLNCLEEMMSKQKPEAEKITCPICRRGTQVPDGGLQSLASSFFLGSLVDEVKQQEEVLGEASALTTTCDCGEGKEATWRCIECSDNFCQECRKAHGRFKHTKDHQIISLGDWQESKMPPAEHSKPITRMCTVHPDHPLCFFCDTCDTLICSMCVALDHRSAEHNFLKIDDLIRSFRSEVENILQKFEKCRQRFKSTENSIVHAQKRLQKKLAQARSDIDAKAEAEIIKIRNKAKLLTDKVNKIGQERDSEYEKALMHNREQMERADQTIAAVNELMSQADDFELLELKPKVMHNLEFQKELKCEPAYHGLSFIGVRCHDVVSDAELGEVCVSEKWQLKGEFSKEGTGDKEFKLATAVACFRNGDIVVTEIFLKRLSLFSSTGQYKTSITQGDARQQLEAPWGVAVSHDDLLFVTDKKKVKVFDNELQFVREFTPSGDDADGQSDSNLQSIVVDNQRVAVADRGRKVISVHNLDGSLISSISNNMVDNFLTISNFGCLVFTNYAGQSVQCVNLKGKEMFRVKTFIKGKAAKPTGVLCEDDETIYVAAHSGKTGGAEVQRYDSNGAFVATVAQGLYNPLEMAFTPAGDVVVADRRSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWP8</accession>
    <name>A0A913ZWP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055952.1">
        <property type="nucleotide sequence ID" value="XM_038200024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200024.1">
        <property type="protein sequence ID" value="XP_038055952.1"/>
        <property type="gene ID" value="LOC119727944"/>
    </dbReference>
    <dbReference type="GeneID" id="119727944"/>
    <dbReference type="OMA" id="TWDNDVI"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972880" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="274" mass="31563" checksum="F4B1C914664A66E4" modified="2023-02-22" version="1">MIPSAINLITFCLDLLAAVTVVSAGESGLKSCLPSQREHRVQGGELHRFYRGPLRDHALVGQAYRNHTARSHASCAGECLRDDACKSFNFCQDGGLCQLNLAVVSRNMSDLFPSNGCLYFDERPHGKCLEYETTEEYKYKFFVLPPPKEGEPYRLDFAVKGKEDAIFALSEETNENNLYDIDIAAWNNQRTIIRARKHSVHFHARVDIPGIMSEHEYRRLWLTYDSWTIKVGRGHEVAPFIEYHDDSHRVHVKYIGITSVWYDVNWIFYTYCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWX1</accession>
    <name>A0A913ZWX1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056042.1">
        <property type="nucleotide sequence ID" value="XM_038200114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200114.1">
        <property type="protein sequence ID" value="XP_038056042.1"/>
        <property type="gene ID" value="LOC119728034"/>
    </dbReference>
    <dbReference type="GeneID" id="119728034"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="396" mass="42757" checksum="5B29ECCF82515D81" modified="2023-02-22" version="1">MSDTEASQSESSDIQENTSPVRSPEPDAGHRGGWVSLLTMWTRGVTRMAILKGLGMMLPTLQDQFGTTTWVIGWMTSLMIGMGGLVAPLAGLLGRRFGSGNVIMVCGTMIGIAFIAASFASRATQLSFILILLAGSSLRVPVVLAKEAIGRCYDKNLAKATGIARTGTSIGLVVAAPLIQISLDKYGWRGTMLLIGGISMHLIPCGALMRKIRTTPSNSYRELPQNEPVSEDISSPSTCASFWMTVFKNFDLSLLRSFQYWSIAIVCVCFSFAYDVWLIYFVSQAQSKGFSLEDAAVFVTVAGVGNLLAKLLQGFIIDAGILPCWSLMVICSIVSSCAFFVTPWLAGYWTMMLTASLVVICDGLLSCLHDILTKQVLGVELMMSLVFFGYPVPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0P0</accession>
    <name>A0A914A0P0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057448.1">
        <property type="nucleotide sequence ID" value="XM_038201520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0P0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201520.1">
        <property type="protein sequence ID" value="XP_038057448.1"/>
        <property type="gene ID" value="LOC119729029"/>
    </dbReference>
    <dbReference type="GeneID" id="119729029"/>
    <dbReference type="OMA" id="MSSESKW"/>
    <dbReference type="OrthoDB" id="6107972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020440">
        <property type="entry name" value="IL-17_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01932">
        <property type="entry name" value="INTRLEUKIN17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="22318" checksum="DB0E39D6988AC42F" modified="2023-02-22" version="1">MAEHRHTSGFLTKIGFLLLGKSPVALSVSALLFLAVLSPMRAEPLPAVECSSPLTELIYTITDAGRFDPRKSFGVLPFNLTGSLPTQLPTMSSSGSTLSCPLMSSESKWTCPWTYDTNYDPDRYPSVIPFAMCSCQGCINRAGEEAPDMQCRPVMYKQQVLRRNGCVDGFFRYDFDFEEVPVACACMQLSTQPQNRPPGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0Q8</accession>
    <name>A0A914A0Q8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057180.1">
        <property type="nucleotide sequence ID" value="XM_038201252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0Q8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201252.1">
        <property type="protein sequence ID" value="XP_038057180.1"/>
        <property type="gene ID" value="LOC119728844"/>
    </dbReference>
    <dbReference type="GeneID" id="119728844"/>
    <dbReference type="CTD" id="6224"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="120" mass="13436" checksum="EA991A606156DF8B" modified="2023-02-22" version="1">MSHFKEPGKGGPAEESTAHRIRITLTSRNVKNLEKVCADLKRGAQDKNLEVKGPVRMPTKTLRITTRKTPCGEGSKTWDRYQMRIHKRLIDLQSPSEIVKQITSISIEPGVEVEVTIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A161</accession>
    <name>A0A914A161_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057567.1">
        <property type="nucleotide sequence ID" value="XM_038201639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A161"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201639.1">
        <property type="protein sequence ID" value="XP_038057567.1"/>
        <property type="gene ID" value="LOC119729122"/>
    </dbReference>
    <dbReference type="GeneID" id="119729122"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="71204" checksum="4A715F0905F41FAF" modified="2023-02-22" version="1">MAEAAAKTVWKISQGHLECPICCCLFKDPKMLDCLHSFCLNCLEEMMSKQKPEAEKITCPICRRETQVPDGGLQSLASSFFLSSLVDEVKQQEEVLGEASAPTVTCDCGEGKEATSRCLDCSDNLCQECRKAHGRVKSTKNHQIISLGDWKKSKMPPAEHSKSITRMCTIHTDHPLCFFCDTCDTLICSMCVALDHRSAEHNFLKIDDLIRSFRSEVENILQKFKKSRQRFKSTEKSIEHARNRLQKKLAQARSDIDAKVEAEISKIRNKAKLLTDKVNKIGQERDSEYEKALMHNRKQMERADQTIAAVKDLMSQADDFELLELKPKVMHNLEFQKELKCEPAYHGPSFIGVRCHDVVSDAELGEVCVSEKWQLKGEFSKEGTGDKEFKLATAVACFRNGDIVVTEVFLKRLSLFSSTGQYKTSIAQGDARHQLEAPWGVAVSHDDLLFVTDKKKVKVFDNELQFVREFTPSGDDADGQSDSNLQSIVVDNQRVAVADRGRKVISVHNLDGSLISSISNNMVDNFLTISNFGCLVFTNYAGQSVQCVNLKGKEMFSVKTFINGKAAKPTGVLCDDETIYVAVHYGSTGSSEVQRYDSNGALVATVAHGLYNPLEMAFTPAGDVVVANRHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1T1</accession>
    <name>A0A914A1T1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057808.1">
        <property type="nucleotide sequence ID" value="XM_038201880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1T1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201880.1">
        <property type="protein sequence ID" value="XP_038057808.1"/>
        <property type="gene ID" value="LOC119729275"/>
    </dbReference>
    <dbReference type="GeneID" id="119729275"/>
    <dbReference type="OMA" id="RVHNTME"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="287" mass="31901" checksum="D906CC420D78506B" modified="2023-02-22" version="1">MAAQRGKGEFGYGSLDSTSDSRYQDGQFGSGQSNEFADLSQQVSSAIFKISNNVTTLEKAVRQLGTPSDSTLLRNRIQASIQTTNKIVSETTTCLKDLTLMSRNLGKSSRLQVDRLTNEYHESVQRYSGVQKKVASKMRSCPNVPPKAPPTSGSMDVVQYDESKKALLEETRRQGIESQLQVQDQQIDYDMNLLQEREEQIRQIEAAMLDVNEIFRDLSAMVSEQGEVVDSIEANIEKASSNVEGANTQLQTASRYQQKARRKMCCIFVCVVVLLAILGIILGVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2M3</accession>
    <name>A0A914A2M3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058087.1">
        <property type="nucleotide sequence ID" value="XM_038202159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202159.1">
        <property type="protein sequence ID" value="XP_038058087.1"/>
        <property type="gene ID" value="LOC119729552"/>
    </dbReference>
    <dbReference type="GeneID" id="119729552"/>
    <dbReference type="OMA" id="HRENHAM"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040133">
        <property type="entry name" value="SNCAIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882:SF3">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="568"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1316" mass="145747" checksum="6271AEBB8EE8211F" modified="2023-02-22" version="1">MEEAEVIDIDDLLGSSTPVEQQDAEEYDFENFPNEGGTPLDPDPTKLASRSQSHNSTSVQGGHKQRNATSGSNQSKQGPRKSSLEEDFKKLLLSSKSSKNKSQELEPSRGRNNNNVTWEKDPRETEGFSDAKVAQNEALLDAFVQGESSDAVLSDEELCIDVNSEELMQFILAFEANGEGNGDKPNDISTCATAKQSIAVNHVQCPSEDQESLNSSISTTESRDGSLTSSLASSDLSPIRTKQKVPRGKSVRFLMSNLLRNNKAQHHLTSRASGSDEDNKDAKRTLTRLKDRNKKRDKEDRDRERIAKQQAKILKTQMSSASSSSKTVAETSLQQQRDRVPDNNAQPRGQMSSVAVATPLSPGARDNTLHKQLIQAAARGDRQVLEFLLAANEGLSEVRDNRGNTLLHAVARRGHVDCLAWLAAGPCAGMLSVENDDCFTAAALAVKHGQVDCVKCLAELPGSASELHTQDHRWSLLHLAARFGQETCLRWLLEHMQMQDITLDQTDHSNNSPAHLAAKYGHLSCLQTLVEFNSDVTLLNKKKQSPCTLATRYHHHPCAQYLVVVETCIKLSNELTVTQRKLRESQQEKDVLAKKLREAMSCTDALVHTQKTDLTQRIEQIQGEYVDLTNLLVRQLDQMHRHQTDAGNQSGSTTSRDDLLVSKQKADQLEQACSELLELDQRQELEANRDQLQEIERRLSRLQPLPTSPIWPAPPTELRTGLALDSMRARLSEVNQQISTLHHPSPSLASDNLDTLSLSSSYTSSLSSSSSSLQTGVVQSSPGHSAKKCKTSWNEELSPRGMSANEGKMETAQPVTQNSLLGSKPSDPLRDTQDQRFSLPHSLDFQTKDNPSVQYMTGGITGSRNDGKNPKLPQSKANVHHVQASIEYSEPLQQGLSVKSTVEKTLHEQFRSSGDSARIVTSPPSYEQFCSKHSKSSLRVESSIGAEDKAKKPDTVLRNQDEEPHCMDKTDPNTSQDRTVPLGWEQQGSPMPYLLPTFEKLPQISDNLHQISAKLYSQNPKHCQQALPGFMRKVQPTNEFGEPESGKVIVKISNREELELLPSPATSKTQELSAHQRVGSNSSVSSLSSDIPWSESDADESPRPVRQPPRGGILSKKSQTKKSQEKHITFALDNKEAKSDPVAPSTNAKPPLNKRRDLSPIYEAPDLVKSTKDDSKSQKKDTQKSDKREASSREADAKKSKDSMSPDDKSPLGGRNFRLFSYSSDEGDHEGSDSHKMRKAIPQHEEENSSFPKDLTDIVSMEFNGIDSNGETSSRCKDDSQEKLWYESSDDEDDPNDNLPFHAESSSGFERHICYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4J8</accession>
    <name>A0A914A4J8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058748.1">
        <property type="nucleotide sequence ID" value="XM_038202820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4J8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202820.1">
        <property type="protein sequence ID" value="XP_038058748.1"/>
        <property type="gene ID" value="LOC119730031"/>
    </dbReference>
    <dbReference type="GeneID" id="119730031"/>
    <dbReference type="OMA" id="PWEPTIS"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="25404" checksum="E6CF854AA541AC26" modified="2023-02-22" version="1">MSYFIVNKLIDLIVDVPRYAGCQESYSGGGISYGVVNIYPKQYPNGLAVTCKQSFIVIQNRKDGSVNFTRSWAEYRDGFGDLTGEFWLGNEIVRQLTSEGTWELRFSLKGDKSSGTSRFRQVQILGDDYILNTDYRSLSGQPFSTYDRDNDADGNANCAAQLKGGWWFKTCTGGDGNVDLVPTNLNGEYSYPVNYTGQDYRGMRWPSSWLSVGQIVSSSIWLYRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4X3</accession>
    <name>A0A914A4X3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058775.1">
        <property type="nucleotide sequence ID" value="XM_038202847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4X3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202847.1">
        <property type="protein sequence ID" value="XP_038058775.1"/>
        <property type="gene ID" value="LOC119730060"/>
    </dbReference>
    <dbReference type="GeneID" id="119730060"/>
    <dbReference type="OMA" id="IASCACH"/>
    <dbReference type="OrthoDB" id="6155932at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="591" mass="65398" checksum="B95A21153169810D" modified="2023-02-22" version="1">MDAVVDGQLSSASSSSGPPSSLSENVEQLPLPDKERYVNKLGNIGTCDPYLIPASCCTPLLKSNLLPKLEFPDIYMYLINFPSSYTGEAMKAYKSLDGYKYFIAGKVNHLLVWHQPMKRDPTTSVFVILSKVHHSQRLNDPPVKVWVAFQEDGVVITAHCTCMAGVTEVCSHVAATLFAVSKGVEMSTTTCTSKPCTWIKPAKSRSSGEDMYAEASNINFSKPKRRMTETPTTLPKSSCKSRSVPPPSKDETDNFFQQLKGTGVPSAILSLVPAYAADFIPKALQLKLPEPLTKLYCAENLKVSYPQLLTKCEAVFNNMTMDVDMCNAIEELTRQQAKSKMWHIYRAGRITASKFKSVVCTDLAMPSAYLIKSICYPAAYSFSTAATRWGCQHEKDAVESYTKCQSSNHDNLHVRDVGLYICPDLPFLGASPDAHITCTCCGDGLLEVKCPFCVKDCNISEGLARKDFPLESSSDGKLYLKHSHPYYFQVQAQLFVSNKPYCDFVLWSQTKPDAPHIERIFPNDVFLKENVEKAKLFFKVGILPELLGKWYTTSNVGEGNTIAECSSQTQVNVCCFCREANTGHGIVVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5S4</accession>
    <name>A0A914A5S4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059212.1">
        <property type="nucleotide sequence ID" value="XM_038203284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5S4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203284.1">
        <property type="protein sequence ID" value="XP_038059212.1"/>
        <property type="gene ID" value="LOC119730407"/>
    </dbReference>
    <dbReference type="GeneID" id="119730407"/>
    <dbReference type="OMA" id="YGYLYLC"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42406" checksum="1D1436DD5735EFA4" modified="2023-02-22" version="1">MDERAEEPLINVQHVFQLSSYGVKQEQVTFPRVTMSSHRWICCRHTSRKRKKVDCITAINLTRKTPRSLTWPCVADSAMMNPRKPWLALKVGRHFQVFNIVAEKQLHRCTTKDDVQYWTWISDDIIGMVGAKAVYHWDLSPPADLGPQKVFIRHGRLSFCQIIGYKADPTQRWLALVGLFREFDNESDNLSCVSGLTQVYSVDHKYSQPIDAQAIAFATYRRSENILPSSFLCLANRSPAQQGKLHIIELGPHKPGNTALISCTEQLFFDESDNCDFPVSVQICSNYGLVYVLTKLGHVKVCDIETGTHLSSASVSPLTLFTGAPDSEGKRALTVDRAGKFSAVGVHERAFIEYTRTQLKRPAIARRLEKCMFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6F8</accession>
    <name>A0A914A6F8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038058996.1">
        <property type="nucleotide sequence ID" value="XM_038203068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6F8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203068.1">
        <property type="protein sequence ID" value="XP_038058996.1"/>
        <property type="gene ID" value="LOC119730263"/>
    </dbReference>
    <dbReference type="GeneID" id="119730263"/>
    <dbReference type="OMA" id="CACHFED"/>
    <dbReference type="OrthoDB" id="6500017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="489" mass="54467" checksum="E9B3500A8820C655" modified="2023-02-22" version="1">MAYREKKTTQRSARARKHCSMVGCSHNRENCPSDGFFCFPKKSEKRLQLWITLSGRSDKRRNDGSLWKPNRYSRLCACHFEDGKKHNEPTLKTAADYSELIAEHKRDASAPCPLASADHNYSRSCQQIKKAAAKTHVHLGTQVTFPEEDSCTCVGAHAQVYVHTMFCCRDGVDVGIQTSFHRDPCSDHTETRDQCVGPDARPGKPECTGFRGWDGTEGAKDSLQDMTGVPPSVFDLLLSLLPPRSKGMCLENCLILFLMKLRFGLPFSLLAVMFSVSRTTASRTFQVVLESLSKATHDWILWPSSATIRSMLPSCFSAYPNARCIIDCFEFKTERPPTVKSQFLMYSSDKGTYTCKVLVGISPHGLISFLSQTYSGRTTDSQVIIQSGFLDVLEPGDVIVADEGFPEIQTEIAGKQAIVVMPPFAVPHKDLKSAYSISSVRVHVERVIQRLRSYSILNGTFPNELLPHVNNIVHMCAVLANLQSPVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6Q3</accession>
    <name>A0A914A6Q3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sigma intracellular receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 97</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059435.1">
        <property type="nucleotide sequence ID" value="XM_038203507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6Q3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203507.1">
        <property type="protein sequence ID" value="XP_038059435.1"/>
        <property type="gene ID" value="LOC119730535"/>
    </dbReference>
    <dbReference type="GeneID" id="119730535"/>
    <dbReference type="OMA" id="EFKDPMV"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="189" mass="21980" checksum="A940B67E162C1D38" modified="2023-02-22" version="1">MAKGLTRVLEWVIVVYFASHIIITIFFDSQAIMPSWLYPKVFLDLVRDYCIFMKDEMMADPSAYPWFMSFVYGECLLQFPFFFVATYAFYKGSCKWIRIPAIIYSVHTATTLQAIFAHMFFQDFTNSPHPGPVTLEERLKLAAIYCPYFFLPVLILLLMLFSDDYKPAKSPEKPAVSTGTSRSRKHKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7B8</accession>
    <name>A0A914A7B8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059311.1">
        <property type="nucleotide sequence ID" value="XM_038203383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7B8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203383.1">
        <property type="protein sequence ID" value="XP_038059311.1"/>
        <property type="gene ID" value="LOC119730467"/>
    </dbReference>
    <dbReference type="GeneID" id="119730467"/>
    <dbReference type="CTD" id="339665"/>
    <dbReference type="OMA" id="MAGLNKW"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="13"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="324" mass="35844" checksum="1FB4F7D74166126C" modified="2023-02-22" version="1">MSPPHIQTMAYLAMAGWIMASIGLSNINKWLFDEEHFRYPVFLTMLHMFSACLFGSVVLRYTPLGAAFGEGNARLQIPPRLTVRILVLSIVFTLAVTLGNIALRHLYISFLKMVFALSPLVTVMLSRIFFHRPVDNYIYMSMVPLCFGSMMCVTGEVNFNIYGFLAAVGATVLRALKSILQGVLLKEQRIDSIRLLYHMSIPSSAMLLAAAVILEPSAFSPATLWPGALRLLSLLLLSCLCAVGYNLMNFLVTFYTSPVALQVLGNVAIVLDVAVSLVVFQNQISWLSLGGIACIMVGTVMYQEAGSVKWYVENRVSRSLNAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7G5</accession>
    <name>A0A914A7G5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059730.1">
        <property type="nucleotide sequence ID" value="XM_038203802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7G5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203802.1">
        <property type="protein sequence ID" value="XP_038059730.1"/>
        <property type="gene ID" value="LOC119730774"/>
    </dbReference>
    <dbReference type="GeneID" id="119730774"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037227678" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="306" mass="33948" checksum="5E4089CC32311D33" modified="2023-02-22" version="1">MNLPVALRTLATVVLVQLVVAESQLRTCSYFGLVPDPLPGEHWMQAASRELHQRCTGTRHSTEVSDGAEATAEVEISSTPSAPRYADCSDIVDSGMFKRGVYTICPPQYPNGLTVYCRGKWIVIQNRKRGSVNFIRSWAEYRDGFGDLTGEFWLGNEVVRQLTSEGTWELQIIVEEAGYYKKIVLTQFKITGDNYTLHVDPPQPWKLDYVAGKSLTDVSLGQPFSTYDRDNDADGNANCAAQLKGGWWFKTCTGGVGNVDLVPTNLNGEYSCPVNYTGQDYRGMRWAGALEFGNQILSCRIAICTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8D8</accession>
    <name>A0A914A8D8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor coactivator 4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060127.1">
        <property type="nucleotide sequence ID" value="XM_038204199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8D8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204199.1">
        <property type="protein sequence ID" value="XP_038060127.1"/>
        <property type="gene ID" value="LOC119731153"/>
    </dbReference>
    <dbReference type="GeneID" id="119731153"/>
    <dbReference type="OMA" id="EQGPQFY"/>
    <dbReference type="OrthoDB" id="6334544at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039947">
        <property type="entry name" value="NCoA-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022174">
        <property type="entry name" value="NCOA4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17085">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17085:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12489">
        <property type="entry name" value="ARA70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor coactivator 4 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="798" mass="90669" checksum="9CDD33BDA8AEC8AE" modified="2023-02-22" version="1">MAEGCEDVLVEVQRKVVCIQDAIASISDKQQQLNNGALGAKSDIHAALSRQLEALRNREVWLLDQVDVILRIQDQLLQQHLVSLMQELGSLQRLLELAQRQDNDGESLNEELALALSRLDLLNLQPLEDTSLSFKADMASLRRAIHDFGEIDAKRPRWTHDLDVGMVKREHEFSTYQLSYDPADWLAKNTPSVSTNYDDEDDFEMLDDDDDQSETDIDVISDAPENTQHEAWPSTGPQPKFDFVHEILNSPLSDWLFDRDHVQRQFKMDMSYYKEVSQDIKSWLTDYEQKMEEEEAQGYSEEDVLSYNKPACACVASEQEPQFYEIENLASLLCCQEASPSNPSPKTTAFNTQTWLASSQEDSQEKGKWLKRPLPKVEEVCRANEPCQDFSECVCDTNCCLDYTDQSSWLSQGGSSKNRGEPVGVSWLSHQEQSDWLAKGNETVASNNMPSPFDNFLNQQSKNTADWLAQGKETSRVSNEMPSPIDNFLKQQSQKIRDWLIGGVKEVGPCSMASGYFEHLSNEPSDWLVQNRPCLTTSQASPLDAYLRQRSERLCDWLKPRDDPPQDPVFSSQIYAKATSNTSDWLSPENSDHGNTVQSVPAFDIFVESQSHQTTDWLSKKKETSTHLVANQHCPLTAYFAQRSEKTSDWLIKADEKNKQCQLAENNQWLSVHIQDNKSHDTSPSPLMELAQRPSNFYKYSDWLQKSDQTYSESKDGSKSVSDISEKWGFVSMSHDNKECVEEVSEWLTHCSLSATEVESHTKENAKLLSSSSPGEKDPASLFPCFTEKTDVEKWLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8I6</accession>
    <name>A0A914A8I6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038060078.1">
        <property type="nucleotide sequence ID" value="XM_038204150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204150.1">
        <property type="protein sequence ID" value="XP_038060078.1"/>
        <property type="gene ID" value="LOC119731131"/>
    </dbReference>
    <dbReference type="GeneID" id="119731131"/>
    <dbReference type="OMA" id="GLKFWLH"/>
    <dbReference type="OrthoDB" id="8958249at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="23">
        <location>
            <begin position="112"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="22">
        <location>
            <begin position="334"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="21">
        <location>
            <begin position="629"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="857"/>
            <end position="861"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="905" mass="104478" checksum="D37178B679C85AB0" modified="2023-02-22" version="1">MFVESYDGSCPSQVCVLWLPSAGIMMNLIRYSSMTSIKKIMFGLVLLSLLSIWFLSYNMMTPLRGDHDRDLHLKLPPSQALGGSEGHPARRRQGKHSPAADQDDLHLIPAALIITERSDSVFAYNLTSALEANHIDFTSVQIKERHWPRLEHKRTGKFSIIIFQSIHSYVSLDPYLLNTIHEYCRKYNVGILAFAVVREDDNGYTRQVGEFPVYMDQRLSLKDLTINPSASDVLHITKAGQFINGTIPYNDWTVFRTDHESYKPLVQAKTLSQDSLQLRSPSEVLHTTVLMDQGHFDGIQRIFIGNNFRFWLHYILFLDSVSFLSQGLLQKSLDRYIQVDIDDIFVGMKGVRMTVQDVEALLLEQQVLADKIPGFTFKLGFSGKFFKRGNEEEKAGDEALVMHADKFAWFPHMWNHAQPHMFSNQSQLVADMRKNFRFAKSHKIPVEDSYAVAPHHSGVYPAYPMLYNAWKQVWGIKVTSTEEYPALRPARKRQGFIYKDIMVLPRQTCGLFTHTIIMKQYPGGRERLDSSIYGGELFQTIVNNPINVYMTHMTNYGSDRLALYTFDNVVNFVQKWTNLKLKAESPLDLAIKYFDMFPEEQDPVWTNPCYDKRHLEILPEKHNCNRLPSFLVIGPQKTGTTALYTFLSLHPNIMSNLPSQETFEEVQFFSNSKNYYKGLEWYLNFFPQVDNTSTDLLFEKSATYFDNVYAPRRMHWLLPKAKLIAILIDPAKRAHSWYQHERAHGNPASLNHTFYEILTSGPEAPRPVTLLRSRCLDPGKYIQHLQRWLQYYPPNQLMVLDGDLLRADPVVAMVKIQTFLPINAFIDFTDKIVYDDKKGFYCLALRKGRTRCLGKSKGRSYPPMDAQMEIYLRHFYQGFNVQLLAYLSSIDQPIPAWLNEALTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACP1</accession>
    <name>A0A914ACP1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protein COX18</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061231.1">
        <property type="nucleotide sequence ID" value="XM_038205303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACP1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205303.1">
        <property type="protein sequence ID" value="XP_038061231.1"/>
        <property type="gene ID" value="LOC119731965"/>
    </dbReference>
    <dbReference type="GeneID" id="119731965"/>
    <dbReference type="OMA" id="PFAVWQQ"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44794" checksum="DB07C213D7433323" modified="2023-02-22" version="1">MALTRLIRSSLTDGRILYHCQLSSLQRCISAAEPTLVFSCLNHWRIRSHKQLHHRTFSHLTRSHDCLTNSNLPSCRTALTYLYHPATLPTVPSLVIQRRCINVANTSSSSYMPTPVECSYEFLEHIHETLTLPWWLTILVTTFLLRGALVLPFSILQQRVLAKIENVQPQINTHAEHMKQQVALKAKELNWSQKEMANVYSQQVKFMVTRLHFDNKCQSRKIFYVGLVQMGVWSSLTMAIGQMTGKYPELFSTEMDVDFLPELATQGALWFSDLTQFDLAIPIMLGVVNLALVEMWSLRRGPLTLLQHRLVNWFRLLSLGMVPIATMMPAALSFFWLSSSLVGLGQFALLRWPAFRRLVDIPPSPSEMKHPLQEMKQAFRVRYFSKKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADM3</accession>
    <name>A0A914ADM3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA damage-inducible transcript 4-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061449.1">
        <property type="nucleotide sequence ID" value="XM_038205521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205521.1">
        <property type="protein sequence ID" value="XP_038061449.1"/>
        <property type="gene ID" value="LOC119732126"/>
    </dbReference>
    <dbReference type="GeneID" id="119732126"/>
    <dbReference type="OrthoDB" id="10018535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24778" checksum="2884A1686A4937D1" modified="2023-02-22" version="1">MALPVNSNCHQQGVSTILQKVLLKFGEKIESRDHERWPEPNYIIETVRGSSDCHSDFNMMDHDAYGENEIDDIREVKMSQYVSSLILDGLKTREKQQTGRLLFPNDLPQRVADDVMRMSLDEPCGVRGCTLSLIFEDGEICQRVGRFAIDPSTVTTFEINLVLTKETPRWLVSKLQTYLRNSYDRPTVIKSSYKLIKRKLYRRESHMYVREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEI7</accession>
    <name>A0A914AEI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038061774.1">
        <property type="nucleotide sequence ID" value="XM_038205846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205846.1">
        <property type="protein sequence ID" value="XP_038061774.1"/>
        <property type="gene ID" value="LOC119732381"/>
    </dbReference>
    <dbReference type="GeneID" id="119732381"/>
    <dbReference type="OMA" id="ACEWNIN"/>
    <dbReference type="OrthoDB" id="639466at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="505" mass="56844" checksum="4921BF32FC2E10AC" modified="2023-02-22" version="1">MAMLGDLYVNATTVLVALTTLAAFALYKSSKRPANFPPGPFAVPLLGNVTSFLSKTALEVMCDLHKQYGDVFSLRFGAFNMIVLSNIQIVREALVTKAVEFAGRPMSYSGEIITEGYKDIAFSNYGPQWRYQRKLGHTAIRHFAQKEQLQKLVFSVTPQIAKVLDDLGDKPFAPKYTIGQIVYNILASLCFNKQYEFNQPELLQWIQLNVDAQTAFGNGLIADFFPALSFIPTPGERKVRKIIAEMLAFFKKELKIHREQFDPENVLDFVDSLLLTQKQALEAGEEEAEHITDTHICQTVFDIFSAGTETTTITLHWAVGLLAENPDIQEKVAKEIDDVLGRDTLPSLDDRGSLPYTEATILEVHRYGSVAPLGVPHSVMTDTTLAGYDIPKGTMVMINHLALHNDPTQWSEPEKFKPEHFLDDNGQLLKKLPESFLPFSTGRRVCLGEDFAKKEIFLLFTWLFGRYTFYKVPGKESESLLTLNKVAALTHQPVDEMEVCVKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEL9</accession>
    <name>A0A914AEL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Unconventional myosin-XVIIIa-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062216.1">
        <property type="nucleotide sequence ID" value="XM_038206288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062217.1">
        <property type="nucleotide sequence ID" value="XM_038206289.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206288.1">
        <property type="protein sequence ID" value="XP_038062216.1"/>
        <property type="gene ID" value="LOC119732660"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206289.1">
        <property type="protein sequence ID" value="XP_038062217.1"/>
        <property type="gene ID" value="LOC119732660"/>
    </dbReference>
    <dbReference type="GeneID" id="119732660"/>
    <dbReference type="OMA" id="HHFFLGH"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01386">
        <property type="entry name" value="MYSc_Myo18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06747">
        <property type="entry name" value="PDZ_MYO18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036064">
        <property type="entry name" value="MYSc_Myo18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057772">
        <property type="entry name" value="SH3_Myo18a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24556">
        <property type="entry name" value="SH3_Myosin-XVIIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="238"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="443"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1862"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1392"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1985"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2040"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2051"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="540"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2096" mass="237208" checksum="49EAB590FF21918A" modified="2023-02-22" version="1">MFHFKKKDRDSKKESKKEKKQEKHSIKQKERHKDKSMTEEELSRLDEIKRGLFPGRKISLTRRQPQVDRTDGYHAPGVEIRNSESNYSMEFTSGSDEQSASSVRSSMEFPVNQQVDEDGDKAVDVNGKTETTITVSETPPLVKKGSGSKKSILKGKSSYGLPDVSSGTVSSKLDDTGVLADNTAYNELIAEKALQAESQFGEFVFEPGASSPGPGEKTFDMDLPLPDLVVPKPPRKRDVMLHRQPNGGFGFTLRRCIIEERSGPGGGITRRTVHFAEPSSTQKDNSSGLLPGDRLVEVNNENVESTPRDDIIGKIRGSADSVSLKVQPIPELIELSHRHGVDGSEMYLEDQILKTGSLAQSSSIRIERGRAKSDAQLDSEKAWLGAERVWLLHKGGFTAAQLLNAEGIVPLSEGRIRVKLAHSDDALEVDEEDVEKANPPQYDRAEDLASLLHLNESGVLHTLRQRYGASLIHTYAGRSLVVINPMHQLSVYSDKHATAVIQLFKGCKQEDMPPHIYATAQTAYRNMLATRLDQSVVFMGRSGGGKSWNARHTLQYLTQVAGTINNMVTVDKIQAVATLVDAFGSARTVQNTSATRCSQILSLDFDHMGQIAAGSLQILVLEKYRVVRRPASERSFNIFYSLMGGADEATAKELFLNHLAPDNVYITPLQRSEDKQPTSTAWSKVLHACNVLGFSSDHCKALWCVLAAIIHLGAAGATKGSGSSKAQFRKPTEAQKAAHLLGTTIEELAKNTFSPRLASGASRSSLRPVVNEPMTEQGATPRDALEGMMVGLYGELVNAVVSLINKSLSSSYRTMSSILVVDVPGFQNPTAFGQQGGASFHDLCMNYAQERLQLLFHDSMFTTQQDKYAQENIDCHFEQAESSPEPMVNLIDKQQGLMRSSNMDLRDVDQKGLLWLLDEESIFPGASDDTFMERIYIHYGHQASKKDSLLRGCKEKNHFILNHFQNTTPIQYNATGWLKVCREHPVVRMAIVVLQESQKTNISGLFVSLAGSLPSTMVGSVAGIEGSSSLRRASSIRRAWSSGTAAIKRKSVCLQVKFQVDGIMESLRRTRLHFVHCLLPQVNAGLCELKNLGAKSPTSPTPTSDGLIDVPYLRNQIRGLEILELAKLHKYGFPESMLFNEFRRRFELLAPANAKVSEPVLDERKAIEELVKHCDLDSSMYRLGLSQIFFKPGALVKVEDQRDERLSKTITEFQAYCRGYVARQQFKQLKIKHLAITAVQRNVRKFLAVRTWPWWRLVTKVMPLLDVHRTEEELKMKDHELTELRIRGEKLEKERNLLKHNHDKMEARLAEMSADLAEEHTTANHASEMLERETAERLRLEKELKDLKVAHGNLQRKAEKLDMEVMESRMMRSSYMDGDMGSSDEEEDSIYRTKYEQARREIELTKKRLKQEHEEEIESMKAAKKAQDRRMAEAMEEVEEERKQVGGLKRKVQKLIGEAQDTRLHLESQQARNSELEKKQRKFDTELHKVQQDLHTDHLAKDKLQREKEALESENYVLRQQMEDMRSDVSIKESRMEELRCEMNDLSSHGSKEVMEVAAIKRQKRELEAKIDDQEEELDDQAGKILQLEQTKLRLEMQLEKQKQASQKDLEVKDEEVESARSTFQNRLKQLENQIEEDYKERQSLMRQKRDLEHKLADLQEHPRTADKDVERRLKKDLKKTKALLNDAQIMLERQKASAPSSSKIKQLKNELEDSQYATMAAVKARQSMENELSELQSQLDDVSRGKAEAEEKISQLNREMNDVQTRHEDQEEDFNDLLKKHKALVLQSSNDQAKVVDHVSQISDLMQAKHELDEKVSELQGKMEFMTSTTVDRTQLTRLEGKARDLESRLALEKTTRQKFENQAEKLKENIDKMSTEHDNRSYKDQKMQETNRRLQRELRELKDEQTDLQRKETEGTKKKLELEETVDSLEESNEKLQSDLKLAFKRIADLQHALQDNDDSGSDLGSSDSDSDDEPEYSRRYSRYSSRSYRDSTSSLESTPRLARRRVLSSASEDATTSRKDKYTVNPLSSDEEEFEPRSTSRPSSMYSEDSKGSKDSGDLLASSPPPGEERDATLTSTGGGTKKKGFVVNPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEU8</accession>
    <name>A0A914AEU8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062485.1">
        <property type="nucleotide sequence ID" value="XM_038206557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206557.1">
        <property type="protein sequence ID" value="XP_038062485.1"/>
        <property type="gene ID" value="LOC119732975"/>
    </dbReference>
    <dbReference type="GeneID" id="119732975"/>
    <dbReference type="OMA" id="RIRCCSI"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="200"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="852" mass="96349" checksum="D42699C5E9BAD40F" modified="2023-02-22" version="1">MGSPKLQCSAIFTVTANAGITDRVLCKISERLDSEWRKLATHLGLSAAEIEHIVMDVPGQTENQIFNMLVKWRRQQSTSTDQRDVLCTALMEIGRMDIVEDLIEITELQGPHTFADLRQQIIDNYKLTAMTIPAHPTLQSCNVGIEQFFIPLHLGKNIPGKTKSERSVTLPERILFLDETQHIILKVVDDLFNQEIVKEIKILLCGGAGTGKSTLLVKVANSCITLGSKPLYGRFELVLWIKLRHMQQSSCVLDYIFDQILARNTKLTKHTVKRFIADHESGIALLLDGFDEIPSHVLESEKGVYRVQDILHNRVLTKSFVLVTTLPHRKQYILRGHPNYAHIQTFGFKPHDRDQYIRLNFPDDADMGEALISHLKVNANIREMAVVPIISQMLCLVWKNQKSLPERITELYEEFVVALFKRRNKDMSDEQVMSNMMSIIDGLGPVALQGLLDSRGERLMFKESEFQSDIEEGRTVGFVQGETFQCGPGEEVLISFPHKTIQEYFAACYLVKLLDDDENNFRHQLEQIGDGNVLAMEYLLRFCCGRSEKAAGLILDHIQGMQGDKKKLQRLALLLLLESGSERLATKLVRPNEVSCKSNKDLKSLSYYLQHVTPPLDGTAFCMNVRKQELTLLRGILLNDSMKSAGLISVNYNLSEQEGEELSLLEETLGVVDKQRRAQLHIVVQFEAKSWFDVERVSHSFFCMQEQIGRLCLNMYQRSPDEVIDLLKALEGCRLGWLTLYHTDLHAQMGDVSRISSSLIYLQLPACRLVDDDVKDLISILPAGHGLGWLNLDGNAFSLDAVRALTRHLQGLPKLRVLSLCNIGLDAKLVRQVVSQDLPHLKETAAKGDFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF53</accession>
    <name>A0A914AF53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038061998.1">
        <property type="nucleotide sequence ID" value="XM_038206070.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061999.1">
        <property type="nucleotide sequence ID" value="XM_038206071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206070.1">
        <property type="protein sequence ID" value="XP_038061998.1"/>
        <property type="gene ID" value="LOC119732515"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206071.1">
        <property type="protein sequence ID" value="XP_038061999.1"/>
        <property type="gene ID" value="LOC119732515"/>
    </dbReference>
    <dbReference type="GeneID" id="119732515"/>
    <dbReference type="OMA" id="MYTGQKY"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="389" mass="45425" checksum="9EF968BBDDDA61D0" modified="2023-02-22" version="1">MALKQLQSSVSYRRCFKRTAFIFVLAAVCLIVSGASYHHAKVKTAISAALTSLSTKPDMPSNSPFTEETRNVSYSNELQLLAGNHSDSVQQILKKLFTAGQKRKPDKHFMEEQAFVQFQRKKTLRQACRRHPYVMQREQSSGQFFVMEKSQILYCSVPKTGCTNWKRVFMVLEGDRPNTENISGNDAHFSNNFKQLSHRRLLRDIRKYDAYTKFLQVRHPFVRLISAYRNKISGETPLVNQGEEFGQMAEYIVRKYRRGAGIEDYNLSTLHVTWAEWIRYLTDPTERRDFNAHWREVYKLCLPCRINYDFIGNLETVGSDSGFMLDHLGLADLHFPSSRAAYLHDSEKRGEALFDQYFGNVSREDIQRLYDIYKVDFELFGFEKPWQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFV9</accession>
    <name>A0A914AFV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD and RING finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062808.1">
        <property type="nucleotide sequence ID" value="XM_038206880.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062855.1">
        <property type="nucleotide sequence ID" value="XM_038206927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206880.1">
        <property type="protein sequence ID" value="XP_038062808.1"/>
        <property type="gene ID" value="LOC119733256"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206927.1">
        <property type="protein sequence ID" value="XP_038062855.1"/>
        <property type="gene ID" value="LOC119733256"/>
    </dbReference>
    <dbReference type="GeneID" id="119733256"/>
    <dbReference type="CTD" id="57661"/>
    <dbReference type="OMA" id="PFQVHQE"/>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16635">
        <property type="entry name" value="mRING-HC-C3HC3D_PHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15536">
        <property type="entry name" value="PHD_PHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057031">
        <property type="entry name" value="SFR19-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23030">
        <property type="entry name" value="SCAF11-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2120"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1438"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1491"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1503"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1646"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1657"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1758"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1784"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1822"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1889"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1912"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1964"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1995"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2040"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2062"/>
            <end position="2099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2287" mass="261319" checksum="B925C57995558BF2" modified="2023-02-22" version="1">MEQEENSDNQLQAGEEPTENEEEGAESAGVEEGLFEAPEDTETFDEEGGNEETLDEEEGEEFEESGEEDDDDDDEEEDEDEGDDVDEDGQEGDDDEEDVDDDGEDVDDDGEDDENEDVDDDDDNDDEWENIDEAQKCPVCLDVFWEKEVGTPESCDHIFCLDCILEWSRNINTCPVDRSLFRSILVRHSLHGEVVRRIEVDERKPDEQDDDDATYCEVCGRCDREDRLLLCDGCDAGYHCECLDPPLEHIPIEEWYCPECVAQNRHQEDSSEEEPETIAHHASWSAEHQDDRSATRRRRHMTREHPPARAIARTHVSERVRARITQARAAERQVEQRMSGTSGTARKKPVKRKTTKKRKTTKKRRTTKKRKVSSKTGTTKTPGKKRKFKRRKKRRSKTNKRVTKAAGPKTIRGRIAGKLMLVKPRTGSMMPDMKVKGQQTLGFRRSEIGAAALTITGSDNLLDPSETASTSSYEAPTTSTRTSQFVSSSSTTDLLGSIISSQDMLHMQSKDVTIHRDGSLTKISLGDTESKPRKPYQLPYQSKGQNPEEKTNPRRSSTSPSDGKRRDNPSPRRHSQSDTEKRTRFHSAKDRKDLEKCSSPQKAKKDIGSRRSGQETEQGGAHGDGHLESGEDDDVGNEDDEGEDGKMEEVEEEGEEMEDNDPISDAEKVSRKHDGSITCQVSSSSFEESQSEEEEGAINENKSPRRPKGRAGLDEEEEGIIRDSEQSKHRDRRSLKARGEDSRNGSGRSRRKSSLEEGLIEEDGDEMPPPSKRSGSFSEEEGLIEDEQDLKMRSVKQHMKSHSDEEGLIADDEDQGSKLKQVLELSKETRKQGSSEGHTGHSSAEEGEVKTDEEEGSSSNRKKRKRERDRERRRQRNRKDTRTVVIDSEMSLAIPKRPMVEIQREQKMNEARKAEQALLREREFDHPGEHGVFGDLRHVIQVKRDVPHKRPSRYENYWAELERHRAIESQLAEKPVTWERVGIYERPYPYEEDWNRMMLERKPLEPQWENFTIHRERSPMDWRKERDVIEGRVEAERRIEMVQQIDHDRRFETKRREGTEQKVAPERRLAERKADAKKDQEREKKSDSSRVGVKRVEINKGRGDHKKVSESKREGKQKGDVESKNAQKGDANRRQKPNPGSENSRRKPEDGKRESHPKADTGRSEKDLLPRKQDRDRQEKGKHKSSTDEKKRREVNKSDPQPRNPESSKSSSNRDKDGQKDKHRTEKQKSERDISKDRRERESTKGRGQQHSNEHSRDKDRVQQQERSEKDRSERKNSTEKQKHHSGSRSKERSTSRGHSDRSSKHSQDRHVHEHYEDPKKISERVDSDKRGSGKYRDHASAPKEKEKNHSKDGSKITDSGRSEQSDVQQATSTSDQQIPTHTKSTKRSIRRARSLSSSQTGETGDEFETSKQQSSKQLPITVPATEMVSDKPIVEKVKKKKKDKTKKLKNKSNEKDGVKGKKVKKTKGGKAKKQKVAGVEIAKAKVTEEAKEDEPQEEQSEEQPKEHHERSEEASQELPDITCPAMSPVILEPSEKAGTEDAAEQTTENLKNQVDKEHTEKAKDEDSSSDVEMVMGPVKNIFDVIIDLSQISSDEEESFPQTLTSAAKQGKDNSLYDPFEPTASPETISSPDISHKHVSQRQSQKSRDRSPTPDRRTKRSPLARRSSPKRRSSRQRSISPKRRSPPRKRASSKDHGHSSRKRSITPPRKSLPKRRSPSPRRNVSVRKRTHSPRRSPSRSQRRPSPKRQLSPRKRSLSPREHSSSKRRREEPSRQRSISPKKNVSPRKRKTSPKKSISPRRRHVSPKRHNRSPRKRSESPRHRAPPQKRSISPRKRSVPPRRRSHSPRRRSPSPRRRSPSPKRRRVSPPRHDPSPRHRNVSPRRHTESSGRQNRSPQRRSISQHRREHSSSKRPISTRRSISPRSSSTSSRSSRSPSSSSSWSSSSNSWSSSSYSRSRSDSRSRSYTRSPSYSRSLSPSQSPSPRSRRYSRDRSSSSFRSESSIFSDRSTTPDKTPAGRSPSPKRLPAVLRQSPTQTSPEYRHRIPSESEKPFPVQPRQELPDSTQGSYRLAPQSPTSPDQTMAPATSTTDSHLASKASSQISHILGQLASNPAIQSAINSANLKSQRETDDSSDGSISGFLKSSEASFNSPSGRPLQINEGTDDKDLQSLGDVSEDNIESSAVDLYNKNSRERYLKKLQHQERVVEEVKLALKPYYQKREVTKEDYKEILRKSVNQVCHSKSGEINPVKIKRLIEGYIKKFHGKKKVEEKKEPGRPDLAFRLLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGA4</accession>
    <name>A0A914AGA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063005.1">
        <property type="nucleotide sequence ID" value="XM_038207077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207077.1">
        <property type="protein sequence ID" value="XP_038063005.1"/>
        <property type="gene ID" value="LOC119733688"/>
    </dbReference>
    <dbReference type="GeneID" id="119733688"/>
    <dbReference type="OMA" id="HANDHPT"/>
    <dbReference type="OrthoDB" id="5988675at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="237"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="840" mass="93860" checksum="D852ADF46B4E1A83" modified="2023-02-22" version="1">MSMGLKRPCHRWVAELADFNFKIKYRPGKSNTDADVLSRMPLDFETYRAQCTSEVSTTHLGATIAAVRADSSGCFPWIDALSASTSNPDDSVMSSHHISKRELKAAQRDDNTIGRAIQFLESGHRPTRQDRMTEPPNTVALLREWDKLELDVEGILHRRSGGKKQLVLPLKYHRSVYKELHEEMGHLGAERVIHLARDRFFWPHMQRDIEHYVSNVCRCLQQRKPNLPTRDPLCSIATTSPFEMVSIDFLHLERSVGGYEYILVVMDHFTRFAQAYPTTNKSGRTVAEKIFNDFVLRFGFPHKLHHDQGREFENQLFWRLQQLSGITPSRTTPYHPQGNGQVERFNRTLLGMLRTLPEREKSRWKESLNKVVHAYNCTRSDATGFSPFYLLYGRPPRLPIDLTFGLSQAKEPPKNHQEYSQRWRRQMEEAYEVARRNADKSAARGKRQYDRKMQSTVLQPGDRVLVRNLRETGGPGKLRAHWESEVHTVVKRLSDDSPVYKLRPERGQGRNRTLHRNLLLPCNDLLLEAPTVSIKTRPTTAPFARPAPEASVQQDPSDTDSEAEYVIQLPTPSSNTNCPAVNTSGLNHDAEVFLPMGDIRNEEVADDPVAAAPEPAAVAHDEPVPVLVPAAVVPAPVPEPEPVPVPVPAAVCPAPVPEPVPVPVPAAVGPAPVLEPEPVPAPAVVGPTPVPEPVAEPIAVPDPVVPDPAAVLEHGVSSEEVPGLEPVVPAPEAEVDPGLHGDAGPYPARQRQPPQRLTYEQLGQPLHTPGGVNGVMAAGLFAGPHPSVLWPQVPMMPQPFHMPWAPQPMQWSTPMMSWPNQQVPMLPWQQWYQQPTCQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGW7</accession>
    <name>A0A914AGW7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063230.1">
        <property type="nucleotide sequence ID" value="XM_038207302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGW7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207302.1">
        <property type="protein sequence ID" value="XP_038063230.1"/>
        <property type="gene ID" value="LOC119733942"/>
    </dbReference>
    <dbReference type="GeneID" id="119733942"/>
    <dbReference type="OMA" id="AVISCCK"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="27"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="466" mass="50214" checksum="47CD6FAEE7B09CB8" modified="2023-02-22" version="1">MYISCPCPPGTPSKTFEQESQPPRTLLLHQNSPGTMMSGAVSYSLGAGRRKARLGRGPRALDQKLHGDRHYQRSRDNAADFANPTDLPNVDYRLDSVTDDRNKWITPFGGLVSRRFGAGYVMMTCGVMMSAAAIAGSFVENSLQLALLYTLLAGTAIGISNVVAKEAVGRCFTKNYATANGIARTGSSVGLIVFAPLVQLFLDTYGWRGTMLLVGAITMHSVASGAVMVATRQPELDQSNAYQTLPQTEHTNSSSAHESTLRSHCGSLWKFVSKNFEVGLLLNSRYWLVAVISCCKIYAYLMWIVYFVSQAQSNGFTLEEAGSFVTIAGIANLFGTISQGPITDRGVMSSWTLVAVCLVMSSVSYLASSLLTSFWPMMTSAVLILFSDGVLSCQMDVLVKQVLGVELLAGALGWIGLKVTLLLVALGFLPGLVYDLTGSYTAAFLLIGSVQAVPLVPLLILRYSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH02</accession>
    <name>A0A914AH02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038062997.1">
        <property type="nucleotide sequence ID" value="XM_038207069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207069.1">
        <property type="protein sequence ID" value="XP_038062997.1"/>
        <property type="gene ID" value="LOC119733678"/>
    </dbReference>
    <dbReference type="GeneID" id="119733678"/>
    <dbReference type="OMA" id="MARCANQ"/>
    <dbReference type="OrthoDB" id="10055277at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="419"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127801" checksum="E1A6E0D81FB5BE6F" modified="2023-02-22" version="1">MVGFDITDDTRKKALLLHYGGEELQDIYDTLKSDSNDYAAAKKALTDYFAPKKNVVYETIIFRRTKQNTTENIDQYCTRLRQQAVKCDFSDIDRELKTQIIEGCTSKHLRRKSLEKDRNLTELLELARSLSLSESRAHDVEADGSQTAVNKVAKPKRNFKKPTRHDTKPPKRTCFYCGGSYPHKNQCPAKGHECSKCGKQDHFEKVCRSDKQRKNTPTRERPRQYKPVANVEDSSSEDEYLFGIHKASSNKQPRVDVRICGSRINALIDTGASVDVMSQRTFDTLKITPPLTKPTHTRVYAYNSDKPLQITGTFEALVTHKENTSSATFFVVAGNCDTLLNFNTALALKIVHISYAVQHDGDILSNYADRFEGIGKLKDTKCKLHIDETVRSVTQPHRRIPFHVRKQTEKELQRLLDLDIIERVGDEPTPWVSPIQVVPKPKSPDQIRICVDMRAANKAVQRERHITPTIDDISKVNGAKVFSKLDLNAGYHQIELAEESRYITVFSTHIGLFRYKRLNFGVTSAAEVFQNLIQSSLHGLDGVINISDDILIFARSQDEMNTRLDACLQRLRDRNLTLTKAKCEFNRDSIAFFGHIFSAEGISPDPQKVKAILSASDPQTVSEVRSLLGLATYCSRFIPDLATISAPLRDLTRESTEWKWTKKHHNAIREIKQRLATSCSTSYYDPAKATQLIVDASPVGLGAILAQTDKTGNQSIVGLASRSLTLVEQRYSQIEREALSVTWGTLHYHLYLYGNNFEVVTDHKPLVTLFNNPNSKPPMRIERWILKLQEYRFQVAYQPGKLNPADYLSRHPLPTTKPASHEEKMAEQHVSFVTSNAVPKTLTLSELKSATETDHALQLCIEALRTNNWKALMKQAVDPDTKSTLQSMYKIRDELTVIPTNDLILRRNCIVIPASAQDHVIELAHEGHQGIVKTKQLLREKIWFPGIDRLVEGKISQCIPCQATSSSTLREPLQMSTLPAGPWLEVSVDFADLPSGEHLLVVTDDYSRYPVVEIVTSTSVKAVIPKLDAIFSQFGIPQIVRSDNGPPFNSGDFKKFAAYLGFKHRRITPLWPRANKNSTNFYAITAPHHTQLQALHPPSSCSDALFAHASLRQTSQQTTLTAKFANATSARNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIS4</accession>
    <name>A0A914AIS4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disabled homolog 2-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063628.1">
        <property type="nucleotide sequence ID" value="XM_038207700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063629.1">
        <property type="nucleotide sequence ID" value="XM_038207701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063630.1">
        <property type="nucleotide sequence ID" value="XM_038207702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063631.1">
        <property type="nucleotide sequence ID" value="XM_038207703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063632.1">
        <property type="nucleotide sequence ID" value="XM_038207704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIS4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207700.1">
        <property type="protein sequence ID" value="XP_038063628.1"/>
        <property type="gene ID" value="LOC119734288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207701.1">
        <property type="protein sequence ID" value="XP_038063629.1"/>
        <property type="gene ID" value="LOC119734288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207702.1">
        <property type="protein sequence ID" value="XP_038063630.1"/>
        <property type="gene ID" value="LOC119734288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207703.1">
        <property type="protein sequence ID" value="XP_038063631.1"/>
        <property type="gene ID" value="LOC119734288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207704.1">
        <property type="protein sequence ID" value="XP_038063632.1"/>
        <property type="gene ID" value="LOC119734288"/>
    </dbReference>
    <dbReference type="GeneID" id="119734288"/>
    <dbReference type="OMA" id="IAGWKIR"/>
    <dbReference type="OrthoDB" id="6158299at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021887">
        <property type="entry name" value="DAB2P_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12004">
        <property type="entry name" value="DAB2P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disabled homolog 2-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="295" mass="34281" checksum="F33A7F1DDC7CC697" modified="2023-02-22" version="1">MLLEKMNGVEVHTSSVDREPKSNEKLEKEISVLKRRLRDANDIIDDMGRQMELQKTRTRQVIAGWKLRLQEGDEKVIQVAREKDEQFTELVSELMFIEGCLKKERREIVEKLNKRDLKIKQLEQTVKKQQKQIHALNKANEKLIGSLHDIRLETPDSSPSPSPVPDSGPEEEPCMENGEGLHSPHLGQFLRPGGMVPRQRASTVELLPSRRDRDRRRGIPNGSILAPNNNNKPQLDSDPHQQPHQHRVRFQDEVFEEDSPRKDFLDVEPMDMRIRKISLPAYRLPTDEEDSIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJH1</accession>
    <name>A0A914AJH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063706.1">
        <property type="nucleotide sequence ID" value="XM_038207778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207778.1">
        <property type="protein sequence ID" value="XP_038063706.1"/>
        <property type="gene ID" value="LOC119734334"/>
    </dbReference>
    <dbReference type="GeneID" id="119734334"/>
    <dbReference type="OMA" id="FTFTWRM"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF46">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="589" mass="66823" checksum="113BBBBBA2F28F75" modified="2023-02-22" version="1">MTEGPTLPSSSSPPDGRVQKEAASFATLVRKAKQQWSHRGIIEIDQQHRLYNVSRCIQMGMRGCIEPHPTSEVESVTHQEEDYLEVTTQKHFEKDIKKQFEFCCYAPKVFTSLRALVGITDTEYLESLAPSGSPVPCLEFITSSKSGMMFFLCNNKAFIMKTEKSQDIAFLRSQFLRRLVGHFHDFPHSLLVKIMGCYYIKMSGSKGLYFTVMQSVFYPDERITERYDLKGCSASRYVRPLEEGSKEVIVLKDNNFDGRKINIGAQASWFRRQVDIDSRFLEEQGIMDYSLLLGIQKLHADEKKTSDKLADVVSRARRSIKSVSDSPSRVCPDCGGRFPTWNRRSNIQNQQPASQPTKLPQAQETDKTGDNTERMVQEILDINVSSDSQQHASGSAGHHRTASGEVRTGTRHLGSAGDEIGNDTTEQTHGKEMEGVTTTGGENERNSLPGMVEDNRNQPELDVQGTRTSQLQHSLNLDPKALQNLSTNYCQCTSRFQLDKCNERNQRLLPDTANPLHIIDGDEDRYFVGIIDVLTQYGIKKKMEYLYKCLRYPTETFSTVKPEHYAKRFRELCNEKTEQKTSPEKGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AME1</accession>
    <name>A0A914AME1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-acetylglucosamine-1-phosphotransferase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064599.1">
        <property type="nucleotide sequence ID" value="XM_038208671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AME1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208671.1">
        <property type="protein sequence ID" value="XP_038064599.1"/>
        <property type="gene ID" value="LOC119735000"/>
    </dbReference>
    <dbReference type="GeneID" id="119735000"/>
    <dbReference type="OMA" id="PSTCNYH"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036811107" description="N-acetylglucosamine-1-phosphotransferase subunit gamma" evidence="4">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="6">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="5">
        <location>
            <begin position="175"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32529" checksum="32836EB133DBE1D0" modified="2023-02-22" version="1">MLVKIVAVITVLLIQDVSVASARQVKMRMVNEPINTGQNWGTNEQESLKPKVKPANFSGPPHLKRLVGRCFSKTINSYKYELCPFQNVTQHEQSLRWNPYSGILGIWQEWEIEGNVFKSMLMKEGDACMSKNRKVTVSLRCGALNSIANVSEPSTCEYSMVFITPLVCHQHSLLVYPTLSESLRSRWDEIEGELFNEEITLQGYQKKLTQIFQDAGYVLNASKKEQLMNAVKGDSLNAPQGDFQTLELCSAAYAVLEEEIRRLKAQLERQAQDPDGNPLFNMDNLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQD7</accession>
    <name>A0A914AQD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 25">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="7 25">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 25">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 25">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="7 25"/>
    <dbReference type="RefSeq" id="XP_038065852.1">
        <property type="nucleotide sequence ID" value="XM_038209924.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065853.1">
        <property type="nucleotide sequence ID" value="XM_038209925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209924.1">
        <property type="protein sequence ID" value="XP_038065852.1"/>
        <property type="gene ID" value="LOC119735949"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209925.1">
        <property type="protein sequence ID" value="XP_038065853.1"/>
        <property type="gene ID" value="LOC119735949"/>
    </dbReference>
    <dbReference type="GeneID" id="119735949"/>
    <dbReference type="OMA" id="TANSPCE"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000014">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 25" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 24 25" id="KW-0129">CBS domain</keyword>
    <keyword evidence="18 25" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 25" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 25" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CBS" evidence="26">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="523" mass="57512" checksum="A61EE68837BB4062" modified="2023-02-22" version="1">MASTQSGWVAPNQPSKCTWHLGVDPKTSPHHHESNAQLLEDRKTILPDILKVIGHTPLVRLNKIGKSAGLKCELLAKCEYFNAGGSVKDRIGTRMVEEAERKGVLKQGMTLIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSNEKVYVLRALGAEIVRTPTSARFDSPESHISVAQRLNREIPNSVILDQYRNEGNPLAHYDTTGQEIWDQCEGKIDMVVLGAGTGGTLTGVGRKLKEKNSNVKIVSFDPHGSVMEAPSFDKETDQTVCFEVEGIGYDFVPTVLDHDVADVWDKCDDKESFLMARRLIREEGLLCGGSSGAAVSVALRAAKTLTDDQRCVVILPDSVRNYMTKFLSDDWMSEKGFLEKVYELGHNPEKGWWWNLSVSALKFHPPMTVLPTVSCQDAIKIMKREGFHQLPVVGEAGEVLGVVTLGSLMSSMVAGRINSATLVQEVLYKTFKKVTLDLTLGQLSRILDLDHFVLVTQKQKVCSQDARVTTKEVIVGISTRIDLLHYISSNQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQE2</accession>
    <name>A0A914AQE2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065858.1">
        <property type="nucleotide sequence ID" value="XM_038209930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209930.1">
        <property type="protein sequence ID" value="XP_038065858.1"/>
        <property type="gene ID" value="LOC119735954"/>
    </dbReference>
    <dbReference type="GeneID" id="119735954"/>
    <dbReference type="OMA" id="HKEDTWM"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479003" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="18596" checksum="5A1B8D621AE85628" modified="2023-02-22" version="1">MAFMRVLWCVVLVSFAPVCQQAECPKCPPMWTFYNGYCYRLFGNAKTFSEAENHCQDFTNVGQGHLTSIANAQENNLLFTVWKSTRGTAEGGLWIGFTDEVEEGNFIWTDKSVVNFTEWSDGQPDNYGGGEKCTHMWYGKYGEWNDIGCDNLFSYMCKMTAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT62</accession>
    <name>A0A914AT62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066848.1">
        <property type="nucleotide sequence ID" value="XM_038210920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210920.1">
        <property type="protein sequence ID" value="XP_038066848.1"/>
        <property type="gene ID" value="LOC119736897"/>
    </dbReference>
    <dbReference type="GeneID" id="119736897"/>
    <dbReference type="CTD" id="55388"/>
    <dbReference type="OMA" id="TFNRIPN"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="659"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="986" mass="109581" checksum="0269B2A9B4C8AB4E" modified="2023-02-22" version="1">MSDDEYAYDDLDSLTALLDEDQDSNPYNEDASMCSGSSTVRKFTVTKQSSSQSRLGQSSLQGQGSSARDPEPTQDVGASEGQSEDEETDKTKTKEELIDELKRMKEKMKLLESQQSSGGVSQTKQPRETFSDAISVHVEVKRVTKKRKPSADRKSPGEKRPYSAEEIGSMADFMETPTLTNPEDWGDSDEEEMTQEEPKSALFGKNSKRVAHTPKNVTRKPDKVSPYKCELCKELLDTKEALDVHMFKHRKESPQDCRVCGMSFNSKLKLEAHARIHRNTAKPGVSSTVPSAKKAFSGKPTGSFQDRRKDDVAGRGPTTTAGKKEKPEHVETNKHSHIRILNPLVSSSKLESMMEGRKMLRLSVLQKYLDTGPISGDWVTMGVIVSKLPPKTSSKGKAFSIWKLSDLSICDQPVTLFLFGKSHDDHWKTVQGSVVGLLNASVMPPKDNAQDDGVSLSIDHPDKLLLLGTSKDFGHCRGRRKDGKACSMVVNMAVSEFCQYHVQSEYKKHSAKRSDLQSSYGGVHPKAFKKKLGTNIIYGGQTYNPVSASVVGSGSTSGAKSKKKETKVALQSLGVKGAKEIEQEARDSVLTLHGRQNNEDTMIKVSGANQQFKEMLSTPCLGSQNLIRHMVKVEEVSKPISTISAKALLKQHQVDMRARQASRLAGNKRWSSTSSSTSAKSCLGESNKGASINNSSSKPRPEQRGMPSQSDVENRTPVLGRGFGEDDDIIFEDAESPQKPTVPWRSVPPKKRSSGRNPSKDEAKRQAIAHVRTKGQIMKADPNQVGGKIKGVVSPRKRDAVKRRVEEDLNRSLEEDNDSESVGQPAKKQKRSFLGQDMDMSQEELKAIVNAKSKHSGLLAEVQAEMEEQYFQQLEKKERLENQMDSIKEKKCRVVSCKTCDYTWFAPSKFCASENHHLARHEATLRYFKCKDCSSRSITFNRIPNKSCRVCGGTSYERASMLKERKGPVLDSERLLIRGEERKWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATK4</accession>
    <name>A0A914ATK4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067380.1">
        <property type="nucleotide sequence ID" value="XM_038211452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211452.1">
        <property type="protein sequence ID" value="XP_038067380.1"/>
        <property type="gene ID" value="LOC119737254"/>
    </dbReference>
    <dbReference type="GeneID" id="119737254"/>
    <dbReference type="CTD" id="28976"/>
    <dbReference type="OMA" id="CDLANDW"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="20">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="19">
        <location>
            <begin position="192"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="18">
        <location>
            <begin position="305"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="21">
        <location>
            <begin position="510"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="70680" checksum="0842E9346B5854CF" modified="2023-02-22" version="1">MLSRNVSHFSRFQRCLDTRLLPRSPHATVVVARGKEIRSSDRHLHTSRPVNVAFIKNLFLGQFNKEDVFPYPEISLEKYNDLTQMCEPIEKFFKEDVDSKKQDLEAKIPDETLQTLKDLGLFGMQVPQTYGGLELSNTEFARIAEITALDGAIAVTLAAHQSIGLKGILIVGNDEQKAKYLPKLATGEHVAAFALTEPSSGSDAASIRTSATLSKDGKHYLLNGSKIWISNGGIADMMTVFARTEITDDQGVKQDKITAFIVERAFGGVTSGKPEDKLGIRGSNTTEVYFENTPVPIENVLGEVGGGFKVAMNILNSGRFSMGSSGAGMLKVAVGMVTEHANTRKQFNTKLRDFGLIQEKIAQMTITAYVMESMAYLTAGMLDRPGPQDCSLEAAIVKIFSSEGSWTHVSEALQILGGLGYMKDYPYERYLRDARILLIFEGTNEILRMYVALTGMQMAGKELSETVKRLQSPLKNPGFVYKAFMDRLLYKMGMKTGVKLDHDSGGVHPAFNDVGKNLEKHVTRFGYTVESLLAKYKKGIVNEQLVLKRISDILIDVYAMTAVLSRASRSKTIGLRNCDHEMLIAKTFCQQAEERIQKNFYDIGQAPDHNGDSSLERIASEVCDNRGYVAAHPLTREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATL9</accession>
    <name>A0A914ATL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066681.1">
        <property type="nucleotide sequence ID" value="XM_038210753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210753.1">
        <property type="protein sequence ID" value="XP_038066681.1"/>
        <property type="gene ID" value="LOC119736741"/>
    </dbReference>
    <dbReference type="GeneID" id="119736741"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="227"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="322"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="419"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="749"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1044" mass="114113" checksum="2AF7C5084F37ADFD" modified="2023-02-22" version="1">MFLWACAILQRGLAVDLDLQDKTATQSSDYYAKDLSIDLVADRAIDGDTTTFSHTGGRLNGAVVQAGLDPSDFSQNTRIGTVTSFQATNGATIPFTSDPAISARYVSVELSGNCLHLAEVRISTNDIITSITPTNVDATSMTVSWSTVPCAIYYYMEYALTNRDNCESINQPTYISPCNMCQGNTVTINGLVPFSQYTVRVKAYVYGAYGPIKTVIFTTTSSAPTGPPTNVAPGSQAQRSLAFSWSLPACGSRGGVTGYDYRLSTSGAAPLTGQTTAGLSVTIDGLTPHTSYSFQVAARTNDGTGPYSVAVTSTTQEAAPTVPRNVRILSTDDMSVSLGWSEPVPANGLILHYNVRYWRKGDMQTMETDPIVIGLMHSVTGLEVDVPYMVVVRAVTSAGPGPWSEPIEAPTTIGVPGPVGNLNFTERTETSITLVWDPPLQPRRPIIGYVVDYRTLERPYRPDFTAEDTYETNEAQNSPFTKTNLEPGTKYEFRVLAKNEMFTGTEHRMLEVYTKPVTDPPAPPKPTTIQEKTTDMTVTISLAAPKSAVYIESYVIEVKKAGTLSVIKRDVLVTRRSEDQVDGYIAAKFPKTSLPAEFVVGDSMMYGGYRNAPLQRDAVYNIRVGSVTKGNEAVTTVTYSEPLTVIVQKPEDVTPSASGNGSTIVAVVASVIVFVLVIIIVIGSVVWRRRTRQHASNSSLVPRTMELVAKPTTYENDQPRAVNPDGDINEDVGLPTWARKLEIKSENLIIDDEILGRGNFGEVRAGGVRIGGQVTKAAIKTLKDSTSDAATDFKVELQTMVGIKPHPNIVRLLGACFHEGILYVALEFLPNGNLRDYLRSIRPMQKGAGHSTDGASPVTSSNLLKFGTDVAKGMDHLSKTGIIHRDLAARNILLAEDLTAKVSDFGLSRGENIYVQKSSTRIPVRWLAIESLTRRVYKSKSDVWSFGILLWEIATYGSTPYPGIESKSLAERLLDGYRMPKPDNCADEIYNLMLKCWHEVPSKRPTFKVLYQALEKMNSKSYENVVLSPTVYENFIIKHEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU03</accession>
    <name>A0A914AU03_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066974.1">
        <property type="nucleotide sequence ID" value="XM_038211046.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066975.1">
        <property type="nucleotide sequence ID" value="XM_038211047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211046.1">
        <property type="protein sequence ID" value="XP_038066974.1"/>
        <property type="gene ID" value="LOC119737000"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211047.1">
        <property type="protein sequence ID" value="XP_038066975.1"/>
        <property type="gene ID" value="LOC119737000"/>
    </dbReference>
    <dbReference type="GeneID" id="119737000"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275717" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="242" mass="26783" checksum="3FD6AFCBB5C97A8D" modified="2023-02-22" version="1">MKAYICLVVLVCLGSVFAAETNKADEVAVKQYEGAPCGYDYPPCDPGLTCMPWGVCEYAHKRMANVEADEVAVKQYEGAPCGYDYPPCDPGLTCMPWGVCEYAHKRMANVEADEVAVKQYEGAPCGYDYPPCDPGLTCMPWGVCVYAHKRMANVEADEVAVKQYEGAPCGYDYPPCDPGLTCMPWGVCVYAHKRMANVEADEVAVKQDEGPPCFYVYPSCERGLTCMPWGDCEYPYKRMAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXP8</accession>
    <name>A0A914AXP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Differentially expressed in FDCP 8 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068463.1">
        <property type="nucleotide sequence ID" value="XM_038212535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212535.1">
        <property type="protein sequence ID" value="XP_038068463.1"/>
        <property type="gene ID" value="LOC119737890"/>
    </dbReference>
    <dbReference type="GeneID" id="119737890"/>
    <dbReference type="OMA" id="PRHENQS"/>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
        <property type="entry name" value="C1_DEF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="621"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="77316" checksum="EDEDBEFE7AFFA526" modified="2023-02-22" version="1">MEAETKDQEDTPSPAQITQTFESSTAVIKFSGTCLGSDSDSFSSENDEEEEDDEPINEESFPDGSQPDTSKSNASRTDLESTPTANWTEESWKSDSGFNSDSQTAQSLRREENHGVSETGQESTDIRPDNERSPNQVVLNKTSVLESTIGNDCIPETSAETVSGNSLSSSPKENVSSQAEGSPRSTGSDRGTHRERFNPFNRVPYIHDDHFDNMSSFPSVSGTSFSGDRDDFGTPRHENQSTSSDTDTEVSLPSKDLDLALITNEDLGITEDHFSQPEGCFGFSRVEELEVAIELCKESVKETREHSEQRRELISRLVQLRMKLLEIKEGPEDDPDIKQVLGHKFVKRKGKSSNHQCETCNSIIWGMLQSWHRCIECGFSCHSKCLNFVKRQCASTKVTHPVLTTHARPVPSVTMDNKNTLAKAQISKRGYIVDICPESGLAAQNYRCAECRTQLSFKGDVSEPRQCDYDGHYYCSLCHWNDTEVIPARVIHNWDFDTRKVCRQSKQYLKLMQRRAVLCVQDLNPMLFNYVEELSQIKKLREEILIMKMYFLSCRKAMEDKLLLQLQNRPHFVDNPDTYSLQDLIDAKDGTLLGTLSGIHGNYAVHIKIECPLCQARGFICELCNSNEVLYPFDMIATVCSHCSAVFHRDCFYKCSGECPKCERLLKERRLRGDKSKMRQDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ41</accession>
    <name>A0A914AZ41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068938.1">
        <property type="nucleotide sequence ID" value="XM_038213010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213010.1">
        <property type="protein sequence ID" value="XP_038068938.1"/>
        <property type="gene ID" value="LOC119738225"/>
    </dbReference>
    <dbReference type="GeneID" id="119738225"/>
    <dbReference type="OMA" id="EWFALYE"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF9">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="176"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="409" mass="44819" checksum="A1A87B09C8DF6E24" modified="2023-02-22" version="1">MEVYFENAKQSIDDQEKQLWDLGHEIWRNPELGRQEFHAHRLLTSFLRERGFEVEEQYIAPTGFRASFGAVDRESTGKLHVCLLCEYDALPELGHASGRNLIAEATVAAALGIKAVIEKNSNGKRLGKVTVLGCPDQEGNGTKIDAINQDFFKDIDLAMTVTPYSANISKPTMLTIMRVTLSYHGKTAHASAQPWEGRNALDAAVLCYNNISVMRQQLKPHMQIHGVITSGGVKPNIIPENTEMKFYLRARDHIDMAFLQQRANAAFVAAAKATHCEIEFNFTDHPYSNLLSNDALAKSYQKHAESMGVEFTTKCDLLTTPVGSSDAGNVSHVVPCIVPAFDVEGGVVNHTSEFTAAAGEEAAHSSSIRVAKALAMTAIEAMNDIAVINKVREDFTAVHGDSTALTSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZY4</accession>
    <name>A0A914AZY4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069089.1">
        <property type="nucleotide sequence ID" value="XM_038213161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213161.1">
        <property type="protein sequence ID" value="XP_038069089.1"/>
        <property type="gene ID" value="LOC119738315"/>
    </dbReference>
    <dbReference type="GeneID" id="119738315"/>
    <dbReference type="OMA" id="YAYEDCL"/>
    <dbReference type="OrthoDB" id="20889at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="194"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57321" checksum="F5F085AFFB184349" modified="2023-02-22" version="1">MLLDVYIKLTSGRVFHMPVSAYETVRAVCEKVATEEGVSASCLRLKYTGKVLNKDHTMDYLGVRPETILKADIIQTKSLTILIKCPAGETIPLTIQNITTLSEIIARIKDKQDKQGPTDSKIYKMKLKGKFLSGDRTLAEDLGIEDEGVLELVEQAAAATYNEEEVVEEELDQATLDELLANFADGLDKNRKVEVVFSFDTTGSMYGSLSEVRNKLDTTVSRLLRDIPSIRIGIMSHGDYCDQNIYVIRSIDLTSNTDDLLGYINNVPRTGGEGPYACYEWVLHKAQELSWSEDAAKALVIIGDVKPHAVSHTDQRINWHEELDKLCKMDIKIYGVQVTNYGSDKYFYKEMAARSNGAYIKFQHFNYLTDMFLAVCYREAGEEQLQQYAEEVKQEGRMTEELTDMFTQLEENPTKSTTEKSEDDTEENKEDDGPRYVQEPWWDPELDHGQPVYTYSLEEDCWTRFGTSFSTPAVGSSQLNNQTGSRIRRSMRWKGKKGSKRCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B039</accession>
    <name>A0A914B039_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068876.1">
        <property type="nucleotide sequence ID" value="XM_038212948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B039"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212948.1">
        <property type="protein sequence ID" value="XP_038068876.1"/>
        <property type="gene ID" value="LOC119738193"/>
    </dbReference>
    <dbReference type="GeneID" id="119738193"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673063" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="18425" checksum="781EE5D81A10ABBF" modified="2023-02-22" version="1">MSNSPISNLMVLAATLAIISAPLQLCSAHPVVQDVTSQDQASSSIISGPSCTSSPLGMASGAIPDSSLTASDSHGSYPPRKARLSGTGWWVCPIGKLEGQWIQVDLGRYTAITGVIVQGYPRTNHILTFAVNYSNTGESNDWQKLTDRGQTVQNVDTALETVAGGTCCGRMLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B168</accession>
    <name>A0A914B168_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070120.1">
        <property type="nucleotide sequence ID" value="XM_038214192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B168"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214192.1">
        <property type="protein sequence ID" value="XP_038070120.1"/>
        <property type="gene ID" value="LOC119739309"/>
    </dbReference>
    <dbReference type="GeneID" id="119739309"/>
    <dbReference type="OMA" id="MQASEYI"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="18585" checksum="584E99F265487ED1" modified="2023-02-22" version="1">MAELNQHDVESSKAQPSGAGRKSACCGMDMDYVRSINGILKGNQIGWTCLAFIMSWFCGLAALSILFAIAMCFGLVLTIVIFVAFAFSLKSKKIDFYLADFLVSIVATVVYFALSLPMLILSGGAPLFILAGIFGFLALAGFFVNILFSFKRWRSSGTRAASDNQPYDTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1I5</accession>
    <name>A0A914B1I5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069773.1">
        <property type="nucleotide sequence ID" value="XM_038213845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1I5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213845.1">
        <property type="protein sequence ID" value="XP_038069773.1"/>
        <property type="gene ID" value="LOC119738870"/>
    </dbReference>
    <dbReference type="GeneID" id="119738870"/>
    <dbReference type="OMA" id="TAFTKCM"/>
    <dbReference type="OrthoDB" id="10047557at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34336" checksum="C40057D4973E99F2" modified="2023-02-22" version="1">MANLDKPPSSEQQVRLMIWTVPRSTSTVLAKCLSCVDNSKVFFENYVAASLLDPTRQLGKYQNAELEEAMGAAFKNASEVAGISAGFEASECNYQWVKEQLEKAHVEKKFIFCKDMAYAISDQMEFLPKGYRHLFLIRHPLKVFPSWKKMLQRMAKLPPDEFSLTDFPTRIFTKGHGFREIHELFEYVTKELGQEAIIIDADDLLQDPKGILSALFKLIGLPFEEKILHWEAGNAVTERWTIPRLLLRGDQLGGFYKNALDSTCFLKPGALPDRSSVSPDILRVVDASMPLYEKMYAQRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1U6</accession>
    <name>A0A914B1U6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069977.1">
        <property type="nucleotide sequence ID" value="XM_038214049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1U6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214049.1">
        <property type="protein sequence ID" value="XP_038069977.1"/>
        <property type="gene ID" value="LOC119739204"/>
    </dbReference>
    <dbReference type="GeneID" id="119739204"/>
    <dbReference type="OMA" id="KQHYQQV"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055303">
        <property type="entry name" value="ATMIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056545">
        <property type="entry name" value="C2H2_ASCIZ_1st_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664:SF1">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24757">
        <property type="entry name" value="C2H2_ASCIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="767" mass="84999" checksum="29F724A88589E73E" modified="2023-02-22" version="1">MVADRTKNRMTVAMTTVEIICPSAEELMEQPRRNVPCTVEGCDKLLPTTTALKMHVIKTHGIYKNKSERVLFTKCRQSKDPAVQKQYFCPVVGCSRHKEGNNPFSNMWPLKQHYQQVHGVRNYLCRKCQFPFAFELQRRKHEKICGKNFTCSCGVPYTTRQALCLHARRKNHELPPDYAEEASNVEQPPQQQVNRRTSPVTKSHNTNENPPSVAVNRILTIPVPVSRVGNIPRLIATPQPLQILEAGTPTNTPQSKNKQKTERFLLPKPTILSIGKAAALHPEITQIVTINKGIVQSFPVTVAPSQPATRYKRTLATQTPQRFGSRGARLAKRQLEGVRKGSVFNPSVLPGGDGSSNSLRVFRDSGMNTHLNSSSNCQTQTIIKRNSAHTQTPGDVIMQEALMSAQINTPSRRQQQLHMRVPEQQVLQQQYPQQDMSALNRNTQTSQTYYQGPSGSLPNNVSSVSSLPGQQTHFTVQMEPRFSSNTTSSCDVQTDDWLSSLAQVSDQGTLTDIAGVPTQTDLNVFDFLNLSSSETQTTISQSAFEDSTATESISTQTTRYPADTTQTSIHTATSDLQSQYVDRLAPQSTMETQTNFYSAYLDAFLLNESQSQTSPGGGLDENNIASCCQQTQTLSSPAPKTDHQQTQTALPDLTLSSSDFLSLDMYTQTIQQGQGGNQNSSLQTQTDSFLEYSLSSMQTQTMADFDLGAFDYQSASVQTDAHFLNSSVRQLTNRTQVQTQTSSSWQLEGGDTSARHVQTDETYRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1V0</accession>
    <name>A0A914B1V0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069888.1">
        <property type="nucleotide sequence ID" value="XM_038213960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1V0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213960.1">
        <property type="protein sequence ID" value="XP_038069888.1"/>
        <property type="gene ID" value="LOC119739131"/>
    </dbReference>
    <dbReference type="GeneID" id="119739131"/>
    <dbReference type="OMA" id="HEDMSER"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000017">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2760:FF:000002">
        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="18">
        <location>
            <begin position="159"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="613" mass="70877" checksum="BE2C73F75D39B57E" modified="2023-02-22" version="1">MSSQPTKRRKVDGSLPLTSLANNHFDFANLENWTPDDICNYLTAKGFADEAPLFKEQEISGKFLDKLTEDLLRKMGVSTSKTRLLKMLKEVHNLKNLCDVARTKVPVDSLKVFNDPIHGQIELHPLCVQIIDTPQFQRLRYIKQLGCAYLVFPGAAHNRFEHSLGVCHLAGKLCRTLQKKQQDLNITEKDVLCVEIAGLCHDLGHGPFSHMFDQLFIPVTLPDSEWRHEDASIAMLDHLIKANHLDSVFADYGLHDQDISFIMDLIDKPKKQNNKRLPYKGCAKDKSFLYEIVANKRNGIDVDKWDYIMRDCHNLGISSSFDCNRLMTFFRVNEVEGEKQICARDKGNLSDMFHARYNLHRRAYQHKVTKIIEIMLVEALVKANDHFLVKGEEGKMLKMSEAIHDMVAYTNMTDDIILQIMRSDNPALAESRRILEMVQRRQLYKFIGQTQRLPPKSVYKEEEEIMKEEIIQAQELENMDGEQLTADQLIIHIVDLNFGKGGKNPIKEVRFYSKANPQEAVLLRKDQVSQLLPEHFAEQQIRVYCKRREDKYINKAHECFQSWCDKKNYTVQKAENDVLDSSEATMEVSTTDVSWLQDTQTPEKQRIPDTEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1V3</accession>
    <name>A0A914B1V3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038070329.1">
        <property type="nucleotide sequence ID" value="XM_038214401.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070330.1">
        <property type="nucleotide sequence ID" value="XM_038214402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070331.1">
        <property type="nucleotide sequence ID" value="XM_038214403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1V3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214401.1">
        <property type="protein sequence ID" value="XP_038070329.1"/>
        <property type="gene ID" value="LOC119739445"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214402.1">
        <property type="protein sequence ID" value="XP_038070330.1"/>
        <property type="gene ID" value="LOC119739445"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214403.1">
        <property type="protein sequence ID" value="XP_038070331.1"/>
        <property type="gene ID" value="LOC119739445"/>
    </dbReference>
    <dbReference type="GeneID" id="119739445"/>
    <dbReference type="OMA" id="MQWNHHK"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275730" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="519" mass="59577" checksum="E6068CDD3E16E9B6" modified="2023-02-22" version="1">MKLLTMFMLPLSIFGHSLVESESTDNKFIFDTFQDPKRDTFLWETFPDDFLWGAATASYQIEGAWDADGKGPSIWDTFSHEGGRVYQNQTGDEACSSYNKLKRDIEMLQELGVKSYRFSLSWPRILPDGTAKSFNKAGVNYYKRLLDALVRAGIEPMVTLYHWDLPQDLQDIGGWENEMMVSYFSDYADICFREFGNRVKLWITFNEQIIFTTHGYEIGSHAPGLKHSGYGAYRAGHTTIKAHAQAWHIYDQKYRNKQHGKVSAVFQSSWFEPKTNSLGDKLAAKRAPEVVLGWFAHPILVDGDYPAVMKEYVANASRLQGLTTSRLPEFTESEKKMIAGTYDFLGLNHYTTTYVSHKARAQPRVASFDLDFDMELSQDEAWPKAASSWLKVVPWGLRRLLGWIKENYGDVPIYITENGMSQSGMDTNDELRIKYYQSYINEMLKAHLIDGVNVKGYFAWSLMDNFEWAEGYSEKFGLYEVDFDDPKRPRTPRDSARAYAEIIQNNGFIHPGSKEKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1Z0</accession>
    <name>A0A914B1Z0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069809.1">
        <property type="nucleotide sequence ID" value="XM_038213881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213881.1">
        <property type="protein sequence ID" value="XP_038069809.1"/>
        <property type="gene ID" value="LOC119739048"/>
    </dbReference>
    <dbReference type="GeneID" id="119739048"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="19590" checksum="506C63934DC61877" modified="2023-02-22" version="1">MKETRVILNDLNNQKRDLLASIEDQHSILARYHLDTEKEERTLQDVRASIDKSRTDLKHTLEMIQLEKTELEALRLQHESKMGDLEKTQLAALQEKAELETLQVSCKEKHAQVERIQKQLNLQRPEKERLTTELSAMEARAVVLHREEEGLEEKCREWDSKVVQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B271</accession>
    <name>A0A914B271_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038069889.1">
        <property type="nucleotide sequence ID" value="XM_038213961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B271"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213961.1">
        <property type="protein sequence ID" value="XP_038069889.1"/>
        <property type="gene ID" value="LOC119739132"/>
    </dbReference>
    <dbReference type="GeneID" id="119739132"/>
    <dbReference type="OMA" id="PLLHIDC"/>
    <dbReference type="OrthoDB" id="10009406at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="518" mass="58559" checksum="E5F154C5E4C7D4CB" modified="2023-02-22" version="1">MAKETTKKNNEGSGKHCVVVGCKNTSKKLRKWKLATCELHASETHEYCVCLQPYKMHRFPNCSNANSAANRKQWVRNINRKDFRPSKYSTVCSVHFEEGKPTSAHPYPTVAMGYIPYKQLSRGRPPPRRRVSTATKAVTVQEKAGGVANMSPHGVERTSTCVQTQGLETKDASVQWYDARVADHTYAHVNPITKSKAKGTQTVKAPEVSAVNLQESDMKFYTGLSVRSFWALVNALVVTLTTTPKFQLPVPDQLLLVLMRLRIALMIWDLGVRFKVSCSTVCDIISFWVPRLATFMRENVIFWPSRDTLARIRPKCFESCHPKATCIIDCTEIFVQRPKNLRKRAQTYSNYKHHNTYKALYCIAPNGFVTYVSKLFGGRASDTFISQNSGFLDHLLPGDEVLADRAFTIEDILPHGVKLSIPAFTRGLKDRRLPEESVTETRRIANVRIHVERAIRRLKCFKILANIIPMRVKNVDDILITCAGLCNLQPCLINEDRAQETSDSDSNDEEGNVFSVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2Q6</accession>
    <name>A0A914B2Q6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystic fibrosis transmembrane conductance regulator</fullName>
            <ecNumber evidence="7">5.6.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">ATP-binding cassette sub-family C member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Channel conductance-controlling ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">cAMP-dependent chloride channel</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.</text>
            <dbReference type="EC" id="5.6.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hydrogencarbonate(in) = hydrogencarbonate(out)</text>
            <dbReference type="Rhea" id="RHEA:28695"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.6" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038070620.1">
        <property type="nucleotide sequence ID" value="XM_038214692.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214692.1">
        <property type="protein sequence ID" value="XP_038070620.1"/>
        <property type="gene ID" value="LOC119739678"/>
    </dbReference>
    <dbReference type="GeneID" id="119739678"/>
    <dbReference type="OMA" id="TRSFCFN"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005260">
        <property type="term" value="F:intracellularly ATP-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18593">
        <property type="entry name" value="ABC_6TM_MRP4_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030240">
        <property type="entry name" value="ABCC4_TMD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009147">
        <property type="entry name" value="CFTR/ABCC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01851">
        <property type="entry name" value="CYSFIBREGLTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0868">Chloride</keyword>
    <keyword evidence="19" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="22" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="34">
        <location>
            <begin position="78"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="33">
        <location>
            <begin position="492"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="34">
        <location>
            <begin position="848"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="33">
        <location>
            <begin position="1123"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="398"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00033163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1412" mass="158131" checksum="D95F1AD8D4C2D591" modified="2023-02-22" version="1">MYGFFRVGYKRPLVEDDLYDILPEDSTNVLVEKLQSEWDKQIDKSKKTGKPPSLRRALLRTFGWGYMLLGIPAFLEESVFKVVQPLMLSQLVLYFSTDLVSIRDAYLYAAGITVCSLLTVMCHHVTFFGVARYGMRVRVACSGLIYRKALRLSNLALGETTVGQLVNILSNDVNRFDLAFMFLHYLWIAPIQLILVTALIWREIGVSCLAGMPILILLAPLQGYMGKLFSRFRSKTALLSDARIRIMNEVISGMRVIKIYAWEKSFAKLVSEARRKEIRKIMHAAYLRSFTLAFFFVAPLLITFCTFVVYAALGNPVIPSKVYAVIPLFYTARLCSALFVPYAIMNGTEGLVSIRRIKNFLLMDELNVEASQPSDAAAPSVAYRGTNAVYLNEVQVTTADETSSPSSDADQQQDSDAPHQHDSDDHQQQNSYDHQQQNSDDHQQQNSDDHRKQNSIVSDAVESPTHSMALLNHTDETRTLSNAAEKAHRPGIRVDKLTGSWTKDLSNAVLDGISIHVEPGELLAVIGPVGCGKSSLLMALLGELPTVSGVNVVSGRVGYTAQQPWILSGTLKDNILFGLPHEPAKYQRVIRQCALSRDIALLPDGDLTLVGERGVTLSGGQRARVSLARAVYSDADVYLLDDPLSAVDPAVGRHLFDRCILSYLSEKPRILVTHQLQFLDKADKILVLKQGKVADYGTYHQLQKHGVDFAALLKKKSKKGDYDGEGGEPPTLERQLSMMSRTSVCSTAVSVPEFEFEAPVNIVPEETAVGTVGIGVYLRYFRAGASLLLLLFWLLMVFGAQAVFSLSDWWLSQWAYSEEQDLAAQNLTSQDGEYFVQYDKRTYFIQPYAIMCCVTIVACFVRSFLFFHIFVTAARNLHNQMFSAIIRAPMKFFDDNPVGRVLNRFAKDIGFMDELLPSTFTDFLQIMVLTLATVIVITVFNPLCLTFTLPIVIVFIFTRRYFLASSRDVKRLEANARSPVFSHLSATLTGLSTVRAFKAQQRFIEEFDEFQDKHTRAWFLFLATTRWFGVQLDSFSVLFVGGVSFTSVLAVNFLELNSGIVGLSLTYAINLMGAFQWGVRQSAEVENQMTSVERVGQYVDIKSEAALETDYKPPPDWPKYGLITFEGMSLSYTDDGPLVLKKINCCFRPKEKVGIVGRTGAGKSSLMTVLMRLAEPTGTIMIDGIDTALIGLHDLRKKVSFIPQDPVLFSGTLRRNLDPFENHEDPDIWRALEEVELKPVVEELPDKLEAILTEGGTNFSVGQRQLLCLARAILRKNKILIVDEATANVDIRTDRLIQATIRQRFKHCTVLTIAHRLNTIMDSDRVLVLDAGRLIEFDEPYILLQKEDGIFMNMVQETGKAETAKLLEVARDKYLENNPTDPYGFLGPKKNHSDLTCISPRSRKAISIETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4L4</accession>
    <name>A0A914B4L4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071216.1">
        <property type="nucleotide sequence ID" value="XM_038215288.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215288.1">
        <property type="protein sequence ID" value="XP_038071216.1"/>
        <property type="gene ID" value="LOC119740085"/>
    </dbReference>
    <dbReference type="GeneID" id="119740085"/>
    <dbReference type="OMA" id="THCEKIT"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037574510" evidence="3">
        <location>
            <begin position="24"/>
            <end position="3306"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1860"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="3217"/>
            <end position="3306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2174"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3306" mass="359255" checksum="8403632F7D939B37" modified="2023-02-22" version="1">MAVLSSVILVIATCLMRSWMAEAVTCFGMSTCENGGTCDAPDYCLCPRGYYSPRCEECRPIDHCLQVFCNSYYDAQCDQCDGDFGSVFGSAYKKTGDQRRCIKQCSWRADSNACFPGSCTDAQCTCSSGFSGPDCRTMDEAQAPVLSELRATLLMGTTTLELEGVGNDTATLYTGVRNSTDIRIHWKSSYQPTGLPNPSAVDGTGQPVYPYIADVNLGIVSARVTALVHFAQGGTYALGSEDCPAAGSQDNPATTLVICEYTFNIDYSLWTPANGDTLRYEVDTTNGGNMQLYDRDNANTILTRYYLGRTVSASANFTFDLDSPYHCLNVSAGCRTTMLYAGEDVTTEADITITWQGWADDLSGIGEYDLQVRQLSGHHGDEMTETFDSPAVYTGTAVSGHTVTLPHTGVYSIVLSVFDKAGNAQLTRRFVFFDDDPDDVTIQSHAVLRVLSANADTDYVWITNLGPARGSTSVVLDWRNRFANTRHHSQGLLKPIGLYASGDIESDYDQNFGRRGRAAVPNALGVTEFRVLHAIDHSGGQTIVNASSDGSHNWSNESTNTQATFDLTLVDGDSIRFWVEATDIAGHSVKDGVLTHVDSSPPVIDDGDGNLAVPSSADLDNVGIAFKTYDIHSGIRTIEWRIFTNESGTEVELARQTLPPVKIDPATEDCDPTSCMCIPIGDCYAVYYGFNPAVHIGPHASDYFVGLTVTNHARLLATTTIKVTVDSSPPEAGLVHDGIRGSNEVDYQEFNELSAHWDGFSDKESGVAFYRYLFDELCWDDPAMMDLVLDNMTQTTATHASWTAPSPGRYYVTVVAYNTAQESSDPVCSDGVVIDTSPPELTQIAISSARMWPGLAKDAEGRVWFINEHRRKMELFNASSDCSLIATPVNDLSVYPDVTASKARPQHINCQKFQGIEEKIFLPTHKHLTISWTGVDPESSIYDYEIGLSSDPSNPTPDLVTFRSTSGHDHFVMYHPHISQGNVFYLVLKAVNKAQASTVKVVGPVIVDTTPPVFVGRVSVHVEDAYLIAEWGDSGFIDDEDTSLRYQVAIGHGPGGTETFPYQAEDDLKVGPCQLRTSCAAFSLDDVGWRLHGDHEYYVSVRAQNGAGLATVGTSSVYRHIVQLPSVGVVLDVAPPGEAADVTLGVAKDIDVQTDTTSISARWFGFEHPHLAINYEIAVGSEGGASDVSNGFIDVGNATFYRLEGLALTPLTTYYVTVRASSDTGSVNVTSDGVKIIQEGQALEGAVIKDGLGCDQDASKGLSHHSSAADQPCQDDITYQSSTSDISVRWTIPEMLQPYVTNILWAVEQELDTFSGNGASKLDWVPMLDYQDLGMAVQHVEAGVGMNDGALIRSKVQFCHDGVCFRPIASDGFWVLSRPPEVGEVTISDIATVDSSTELSVVFQPFIHEYIQHEDQLALMDHYEWNIAVEGGAVLSDWKLAENLLISGERAHFTASYNGLLDPRLCHRLSVRGFNKAGLSSIASTNLPDCIALSTPHDVIDADHEVHLELNAAWHEPDKDYISSTTSLSAVWPQLRHRAYVWAAIEDIGTTEFGNLDNGLQFPCDHPMQKACGQTDKEFVNVPGLSLQHGSCYRICIHANRVVLQHETWNQTLPSVSSCSDGVVVDTTPPTPGSVWIGGGQHQAFQRSSSELVLHWDSFTDGEEHGLSSHHAGIQYYEYAIGSFRGGSDVTDFTRLGLTDSVIVNSLRLQHGHSYYGTVRAYDFVGLFAEVTSDPIIIDAMPPAVNDSFTLNIGGSFIRSTTSLSASWENVFSDKQSGMAYYEWAVGSHPGHADIMPFTRETSESGTSDPSQPLRLQEGHSYFITVKAVDHVQLIRSKSFGAYVVDASPPLAGHVFDGDPSTNHRDRDFQEDRTAIEASWEGFHDPHSALVGYSWFSGTCPGCSDVVPWQHVGLETSVTAENLNLVPGLTYYVTVTACNAADLCTSVTSDGVTVDDSPPVVGRVYDGGPGGGDISFQSSRLQLRAHWWGFHDPHSGLSHYEWRAGTTPGAEDILPSTRIELSEDALIFLSDSDQMPIGTDIYVTVRAYNRLGSWSQATSSGFRVDSSPPDVVNAPAVDETFGTAVQNTQVLCDLIRISWLFQDPESGIKEQYLSVSTHRNGDINIPPVKVAGSETDHTFTNLTLSDGSRYFITVSACNYNGLCMESKAEPLLVDASPPSQGRFASGTESASNPEPTSPGPELATPTTPSPYHSGWMTWVEDPRTSLGSLALAWLGFADVHSGISHYLVSVGRTYDGSELTSRGPVRIDHRNNDSMSTDKETLQTAVIPLEGSITDLEPPYLYISIWAVNGVGIPSARLHATFEASPTSPIEGALVPLQNCVASTCEGHCGCAQSNRGCSVGSEICNDVSNSNPNSEIEVLDVLDIMFDGVDYGIDVDDTATQYMMAAVWRVNDPKGLDIKWYECSIGDDSSTPSQPAGVFDPAMEKIWFDVGQDNHTVITLNKDQKLTKGVQYYFFVRAWYDANTYAVFRSDGITPDVTPPKVSTASSFKVKDLARSESRKDVDYLTDPNTVFISWEGVFRDDAMSHYQVSLSTYPGGEDIGPFSNCTLPASEFTTGLANLGLHGGQRYYANVRAFNKAGLHTLRSSDGFVVDTERPHPGVVYDGIGLHDVEYQNSSTVISASWHGFVDLESFIDHYEWCVGQTPSPEDDGILPCTDVGLHLSASRTLVVRITEGIRYYSKVSAVDAAGLQSVIVTSDGFVVDTSAPEPLEHIRLGENLLTNPSFEGREGQDPVPHWEVEPGSDVSVEASESKVAQDGRSFLSLHGAVSQTFNTVQGSHYQVVVFASHAVQSHNPLLNQEGRIEAPGLNRVFRLYDRPAHGHSDQSLMSVRWHQHRFYFTASDAASTLKMSSVGHSNGILLDNIQVRLVTTGPSTGNGSVEVHTQFIHSWSSIQAKWHFVDPESPIVDYSWAIGTTRGGTQLQSFTSVGTQTDATNTRLSMKHGSHVHVTVIARNAADLVAVATSGPIIIDFTAPVIEYVIDGGEESDIDFTSNDTDITFSWSASDPESGIEHCEWAVGLEPGLADVIPTSQMPAAVSPVTASLPQASLEGQRLYTTITCHNHAGQSSWKSSDGVTIVTEPPSAVAAFVRVKTVSETQYHTRDRHQSQKDSLKASWEGFADPFGIQFYECHLNGPDAVTSWKFCGSTSETNLDWSGLSLVDDATYTLSVRAINHAGLTSQAIGQSFSVESSWPTVHALSLLRSSWLGNTTVDLAWDGLFSSPSSSLVYEVSLGTIPGGSDIMQWVETMETGMRVSPLAPFTDYHLTLTVINASGLSETVNKIINNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4Z2</accession>
    <name>A0A914B4Z2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071321.1">
        <property type="nucleotide sequence ID" value="XM_038215393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071322.1">
        <property type="nucleotide sequence ID" value="XM_038215394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4Z2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215393.1">
        <property type="protein sequence ID" value="XP_038071321.1"/>
        <property type="gene ID" value="LOC119740176"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215394.1">
        <property type="protein sequence ID" value="XP_038071322.1"/>
        <property type="gene ID" value="LOC119740176"/>
    </dbReference>
    <dbReference type="GeneID" id="119740176"/>
    <dbReference type="OrthoDB" id="6093123at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324141" description="C1q domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="168"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="33328" checksum="ACE6A9754EB03967" modified="2023-02-22" version="1">MTNLTSRLFLGLPLLLLLSTTGTLALSTFHQDVAFSYIDTEDITQFPRNTYDEPPLLDRLGTGPVFVAPFPGTYVFSFHAPGTGKNFSGPPSRINYQFSWSPGGVNPQSVLRLTGDGPVAGHALLDLESDDRVMIEILSGSATPIVNTTTPVIFNGFLLYHRCLCSPLVLRQSAFSASRKSTGLGPGTLFIDYFEMDLGREDEFDTANGIFTASLPGIYVFMYSFPNQGVGRPGSVTVSLTVNDAVKSSVTSVSSAAAIVEYAGTTVVLDLVVGDRVRLEKRGGQLDIPEVYVGGTLEYVSPILFSGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5Y6</accession>
    <name>A0A914B5Y6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071646.1">
        <property type="nucleotide sequence ID" value="XM_038215718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5Y6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215718.1">
        <property type="protein sequence ID" value="XP_038071646.1"/>
        <property type="gene ID" value="LOC119740418"/>
    </dbReference>
    <dbReference type="GeneID" id="119740418"/>
    <dbReference type="OMA" id="RCNVIPC"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000094">
        <property type="entry name" value="cytochrome P450 2J6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57336" checksum="D583AA351C7D55E8" modified="2023-02-22" version="1">MRMAVLHSSVILRCLARLLQGSFVSLVLVALAWALLQYNSRGMKRLPHGPTGLPLLGYIPFLGRKPYLTFTRLARRYGSVFSVQLGAKLLVVLNGRKAIREAFVTKSRAFSGRPRWVLNRVNQGKGIANQQANPTWREHRRFVLSVMRSIGEGRTQMENKVAEEVSHLIAEFSSHHGKAMDMTYPVQLAFSNVICSVCFGQRYQPNDPDFKRLLHMADVFFSHLTSASAANFIPLLWYLPLPGHRAVQETYAGILDFVSARVEEHKANLDPDSPRDLIDIYLIEIAKRRAESPDLPTENGFTEDYVQHVVADLFFGGTETVNAGVLWGFVCMVMYPDIQTRVQEELDEVVGQNRAPTMADRAHLPYTQATLQEINRRCNVIPCAIPHVTTEDVEMNGFILPKGTTVTANLYSAHMDPVYWREPERFDPTRFLDETGTLIKGNDSYMPFSLGPRACLGEQLAKCEMFLTFTGILQKFRLELPEGGAPPTLDGLPGITHAPRATKIRPVPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9Y9</accession>
    <name>A0A914B9Y9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073008.1">
        <property type="nucleotide sequence ID" value="XM_038217080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9Y9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217080.1">
        <property type="protein sequence ID" value="XP_038073008.1"/>
        <property type="gene ID" value="LOC119741329"/>
    </dbReference>
    <dbReference type="GeneID" id="119741329"/>
    <dbReference type="OMA" id="ITHISQW"/>
    <dbReference type="OrthoDB" id="6343311at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRNT" evidence="4">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="217" mass="23938" checksum="7F96F8162B355091" modified="2023-02-22" version="1">MALRYFPQDACDTETGTECDNKPMNVCVANSSVHTEHRSTNMARFVASFMRQRRTCSGSLGIFWLGIALLCSLSGCLAAKGDEDACKICYCYKTKVDCNGKNLSSVPSGIPHGTTSLKLKDNLLTNIQKDDFKNLTELRYLHLDGNQISYIQGGSFRHLNSLQVLLLAKNRLESLDSNTTEGLRVEASKSYISLADNRLTHLSPYTFSGADGLDGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCW4</accession>
    <name>A0A914BCW4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038073276.1">
        <property type="nucleotide sequence ID" value="XM_038217348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073277.1">
        <property type="nucleotide sequence ID" value="XM_038217349.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073278.1">
        <property type="nucleotide sequence ID" value="XM_038217350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCW4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217348.1">
        <property type="protein sequence ID" value="XP_038073276.1"/>
        <property type="gene ID" value="LOC119741551"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217349.1">
        <property type="protein sequence ID" value="XP_038073277.1"/>
        <property type="gene ID" value="LOC119741551"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217350.1">
        <property type="protein sequence ID" value="XP_038073278.1"/>
        <property type="gene ID" value="LOC119741551"/>
    </dbReference>
    <dbReference type="GeneID" id="119741551"/>
    <dbReference type="CTD" id="23770"/>
    <dbReference type="OMA" id="ICVASMK"/>
    <dbReference type="OrthoDB" id="532682at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="422" mass="46425" checksum="C80C0D835DBD7ED1" modified="2023-02-22" version="1">MDAEDIKPIVEAGDHGYAANEARKGAVNDVQQDAHTNACNGSVDHNMETEDKDDDSDTCMPELIDSHPSMTTPDSPPITNGDTTRKEEGATTESKDNDEPPEWMDVIGNGQLMKKILNEGQGAATRPQRGELVTLKSKGLLEDGTEVDCHEEVSFVLGEGDVVSAWDLCLSLMDLGEVSIIKTSPRFAYGILGRLPDVPPNAEITYELELLNVQPAPDPGEMTIDELCLAGDKKRERGNELYSRKDYSGAINSYTKALKLFEKAKVSDDDSAKLAVMELKVKCYNNLAAAQLKIDAYDPALKSCSNALDIEPENVKALFRKGKVLASQGEYEQAIGTMKEALSREPSNKVIHNELSRLTNRESKERQSERQLYQRMVGDMASVTQINPRQKMNKWLFLALTIGVVILAIAAALSTQRFKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDE6</accession>
    <name>A0A914BDE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette sub-family B member 10, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ABC-mitochondrial erythroid protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette transporter 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>biliverdin IXalpha(in) + ATP + H2O = biliverdin IXalpha(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:82359"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:82360"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073870.1">
        <property type="nucleotide sequence ID" value="XM_038217942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217942.1">
        <property type="protein sequence ID" value="XP_038073870.1"/>
        <property type="gene ID" value="LOC119741970"/>
    </dbReference>
    <dbReference type="GeneID" id="119741970"/>
    <dbReference type="CTD" id="23456"/>
    <dbReference type="OMA" id="MYTGHTL"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000048">
        <property type="entry name" value="ATP-binding cassette sub-family B member 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="23">
        <location>
            <begin position="125"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="449"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="694" mass="75231" checksum="716469E2EDDCA4D1" modified="2023-02-22" version="1">MYAWPLLQSAHCKRGIMRFLKIRMLVPSGSRCQAATRQLHSSILFSKPQSVTKQLPKCLSLPYTKRLPLATCLGSWRTYSSSDEKSDLDSSVATKEETAKAVVPKLSEMTRLMSLAKPEASRLGVAIALLAFSSGVTMLVPFALGKVIDVIYSGSYDSLGSGVMMTNLTYLCGVLSAVFLLGAGANFGRVYLMYTSGERVIKRLRESIFNSIMKQEIAFFDKTRTGELVNRLSTDTTVIGNAVTTNISDGLRALAQAIGGVGMMFYTSVKLATIVISIVPPVAVIAVVYGRFLRSISKQVQDALAKSTEVAEEKISSVRTVRAFAQENREKRAYSSSVQHVLDLATKESLLWGAFYAAMGLSSNLIILAVLYNGGAMMTDAQITVGSLSAFLLYAAYVGISVGGISSFYSEMMKGLGASTRLWEILDRTPTIPLTDGLVPNTSALQGHIDFKNLHFAYPLRIDQPIFKELSLTVPAGSVTAVVGSSGSGKSTLGSLLLRYYDADQGQILLDGTDVRTLSPEWLRCQIGTVSQEPILFSTTIGENIAYGANNPESVTSEELVAAARTANALGFIQAFPDKFDTLVGERGLMLSGGQKQRIALARAILKNPKILILDEATSALDAESEYLVQEALQRLMVGRTVITIAHRLSTIKRADNIAVLDKGSVVELGSYEELMRVEDGVFRKLVERQTVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDL4</accession>
    <name>A0A914BDL4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074149.1">
        <property type="nucleotide sequence ID" value="XM_038218221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDL4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218221.1">
        <property type="protein sequence ID" value="XP_038074149.1"/>
        <property type="gene ID" value="LOC119742181"/>
    </dbReference>
    <dbReference type="GeneID" id="119742181"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="104" mass="11898" checksum="894EDDD15641A842" modified="2023-02-22" version="1">MPHMAQFVYDFYQDKIQRPQASRGHQRQMQAELAKPPVSREPRPAKPADCEQPKPPGMPADVQAVGEASKPKEEETMEEGKSDEATKEKTEERPGEGRIRRWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEP3</accession>
    <name>A0A914BEP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Proteasome activator complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074340.1">
        <property type="nucleotide sequence ID" value="XM_038218412.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218412.1">
        <property type="protein sequence ID" value="XP_038074340.1"/>
        <property type="gene ID" value="LOC119742473"/>
    </dbReference>
    <dbReference type="GeneID" id="119742473"/>
    <dbReference type="CTD" id="23198"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990111">
        <property type="term" value="C:spermatoproteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="10">
        <location>
            <begin position="315"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="9">
        <location>
            <begin position="1735"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1821" mass="208496" checksum="3765B4ECCF6E16F0" modified="2023-02-22" version="1">MESISDRELRLGFKPQHEVVYNKLLPYADDIDDESNKLLAEIKGNLARTVLLRELRPGALYWVARLNTYMTLYGHKFSKEDHIFLIKLLYELIIIPDLELALIDKFSANFCRLLRKRKLLSRDDLVLQWRPLYELVERVLCSQYEDLGLAWFPRTIEANVKNVVRVARQYFPVESTQEMLDEWRPLLCPFDESMNKGIAYLELFLPTLLPPEQHQFGFKLWLDELLGIWDSPHNGMTWEEKLVELFSRVANNNIGYIDWEPYMAKIFTRFMRGLNLPVGAKKLPATCPIKGFEVGVTATWIVAMMGNTKLCQEHLSNFFNAVESYFHPSNIGKYTLKLQPILSHLPSAFIKRLRRERYKKPTWVHPIPDSHKLSDDDITAFVECLKPSVFLAMYSKIGSMEAASALQHMARVRPELVIPQLLEKTYTALDTLTEPHQLIATVSCVVSVSRSLLRSSKWYSEGRSHVLPLLNAMLPGIDPNDFAKCMITFQTISTFISLVPLVDCSEAPLVRDDLTEQERELCSATAGFEDFILTFMDRCFSLIDNSTMEHIRSQDSNPNRANQQENLFDMGLTSTFSTIMTQCSPQLYKVALDRLFSFVANKVLETKVAGKMVAHMCRSATKANAKMALRKFIPHCSGIILNLTASEEVQLEEHLDGELLFNLQILSEIVQCPSHDLLEYQSTLVSVLQSTLHLTCKEGYGFACTLLKHTLKACCMIYPLEYCSVPGGLDRPLNEYLPIRDWGTSTDIDNLDIKWHLPTEKSIKAIKDLMKMFFDPEISKIQDFIKGEELSRERLLQSLTVIHEFLTGAGFVIPRWNKPVVTNLIETVNQERVPHPMQVGISEFSSAFSRIREEITLVMHDLMNHMLATGEDDTKALQLVCRIQHALLWFTGTQKQRSETRMKSWKMIKKAIGDKLHGKNRMIRALQIDRVQIQHDQRLMNQLRYVIYSEVDQMVLHDLTMLSMSRYSEVRKVAQNILFESIDHLTYSRYDIIPRVLENLREDESISHHTFKGALHILQAGGMGTLACVHDWELMQKCWTALVKAGHSEKLSIMKVIDGITVKIHKVYDTLAIKNQVSQECVDVAGQLSQSGSPSTVVKAPTPEEMEQAVVRLKNNNDKNLSIYTNMVTSLVELVERGNLRWKFSQMATGMLKLMVRPDTPLPTAMVRLFTNFLVDDTLAVRKVAIAVVGAILKVLKRPHKETPLDPYAVSGASPPARLAPGVRPDNQWHFYDSSKMPRTETEWEACVFVEKTHWGYYTWPKNMVQYAPYSEQPKLDRSRDELSENEKVIYDCFSNEDFVEKLVRFLSLEDRKGKDKFSAKRFILFKGLFRNFGDTFLPVFKPHLSRLAQSKQESEQRCLAEIVAGLSRGSKHWGFTKTAQLWEFLVPVLRTAISLVTIETRSDWTTCISTMCESRDPRKLQWLLEAFMEFPTFVEGGSFLEASWLLILQGSLAQQEWRIPELLDRLLDHLEKNLAHSYKNVRNQIGSSLSNVFLYDCALPNGSPSSPRSEAFLDRVLPQLAPLQDLDPFQSLESVNHAVTSLNDQDTREKEEAIRTCKTVMKCTLSRLFAPTAPGVYKLLPLVAPLESYESDEELSQLSRFWMAAMAKTLLKPEVVPIVLHSLQQISQGTSWRAKVSLLAYLQVMVYYNLFTVSSQSESVATIHQLVLDLLKDDRLEVREMAGTTLSGLLHCGVFSIEPKLQSHFEILCKTRLPTKKVRLQSDFNNDEFSASVVQRHAGIIGLSACVQAYPYDVPEWMPGVLMDLTDHLHDPQPIEMTVRKTLSDFRRTHHDNWHEHKQQFTDDQLVVLTNLLVSPCYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEW6</accession>
    <name>A0A914BEW6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein moonraker</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074786.1">
        <property type="nucleotide sequence ID" value="XM_038218858.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074788.1">
        <property type="nucleotide sequence ID" value="XM_038218860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218858.1">
        <property type="protein sequence ID" value="XP_038074786.1"/>
        <property type="gene ID" value="LOC119742696"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218860.1">
        <property type="protein sequence ID" value="XP_038074788.1"/>
        <property type="gene ID" value="LOC119742696"/>
    </dbReference>
    <dbReference type="GeneID" id="119742696"/>
    <dbReference type="OMA" id="LERPWNG"/>
    <dbReference type="OrthoDB" id="10072648at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031447">
        <property type="entry name" value="MNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15732">
        <property type="entry name" value="PROTEIN MOONRAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15732:SF4">
        <property type="entry name" value="PROTEIN MOONRAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15718">
        <property type="entry name" value="MNR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120453" checksum="0ED4C185A2F88397" modified="2023-02-22" version="1">MFHQNQLQFNLDVPSLPGNLAARYRHPGPLVIEKLGGGTTNAESAPEKPKDPPVKFTTISEDRLSTAVRLARLDLKNIASKSQTPDINKLSRQEPRAGKKSKPKQSPSGKNHQRLHNTNVRFSERFTDPNESQRSVETQTRKSKKRTKDTIVLWPVNSYGLVLNAQQHQQGDAGNRGGVSPPSRELALSPNSRQAQEIRRLRSELKTYMKKVEELSIKASQQRQEAAKKDWEDAEEDPRRAARAAEHASRSARLLYSLQQQVREIQEELDKLGPGKVRHTKKSRALNRLAAAHRGAVRALQSFLHHLPSEIDHRSGLPPHYQELALLIRQLSLCCSQLDVEESGIPEGVLNILEQAKDFQDALSQQISSPPRPKANPVPQPHASPRRRLAFETNTVRVPHGKPAPRATVSKNLRVDQRYASPMALNPHHYRVRETPERDTDPPRATTRGTSHTTPHATPGPATVERLRQTVVNNKATPGSPERNAALRAGLEALLRAGGHAQGPAHSTQPATKMLQQQPAGRARKQPAVNGFKAPSKSLILPAKLKAARERLQRARTIPRDAHFIQETLASKLKHRDPAGQTGTADPAARPQDDGAAKPAWTPPGSPRSFHKVSPRARRVSVSSENEDGSVIDWEHSPRRRKVNFNLEEESQDKKDPRREGERRLDPDLMEREIARQAWLDREAVKQLKHLDRGVEADGHPPVPPHWLEEVEQALTDRLRPLIDKAEATAKEQERIQNSTTQSLHHQLSQRAAQATSNNAELLSDLLLDDILADTALEFHRIERDEQLDQQARQLVEAPTVEGMLQSLEKMELMEDEIRRRWKRVEYIEQEELGGKSIPHREAKWMMGTPLDGEFLESFPGDIPTSHTSMQFTKSRPRDTNRSHPSVSTARPLYDMNIPARTNASIHPTLGGDDGDNGVRPPAGNDVQIIEMDSRENATEPIGDTPGTTVDQTHHMNILHTLLDNKSNVAAAVRPGTVLGSKESGTRPVLNRPRFPLFIPLDTMSRIRDHRVRFQHHLKRTSHWAYGTFDPWRLVEEVSDEIVSEIIKDVSSEVGDIMGHCVDDLYKAEFDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEY0</accession>
    <name>A0A914BEY0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060217.1">
        <property type="nucleotide sequence ID" value="XM_038204289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074803.1">
        <property type="nucleotide sequence ID" value="XM_038218875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEY0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204289.1">
        <property type="protein sequence ID" value="XP_038060217.1"/>
        <property type="gene ID" value="LOC119731207"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218875.1">
        <property type="protein sequence ID" value="XP_038074803.1"/>
        <property type="gene ID" value="LOC119742707"/>
    </dbReference>
    <dbReference type="GeneID" id="119731207"/>
    <dbReference type="GeneID" id="119742707"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324142" description="F5/8 type C domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="217" mass="23824" checksum="233BEA08D9F17103" modified="2023-02-22" version="1">MDEAAALVLMLSVMAVLLVGVESQQRVCYSGPPPEPDSDNPDDWMKQVMPEIRKRCPGRRQPTPAAECSSPQPLGMVNGTIRDDRITASSSYSCCPASDGRLNNNNGWVAYTFEDANPWIEVDLVEPTVVTGVTTQGLYGYYVTAYKVAYKKQPSSEREHVTDGNGKVKVFVGNIDGNNPVTNLFDESVAATVVRIEPTDWQHEASLRLELLGCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFK0</accession>
    <name>A0A914BFK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074706.1">
        <property type="nucleotide sequence ID" value="XM_038218778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218778.1">
        <property type="protein sequence ID" value="XP_038074706.1"/>
        <property type="gene ID" value="LOC119742641"/>
    </dbReference>
    <dbReference type="GeneID" id="119742641"/>
    <dbReference type="CTD" id="6749"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21994">
        <property type="entry name" value="HMG-box_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000119">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="562"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="562"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="629"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="742" mass="83949" checksum="7CB3AE0B18CB51E8" modified="2023-02-22" version="1">MTDILEFSDIWQEVRGAMNGGRLKLNRQGVYFKSNKTGKVEQVQVEDLAETNWLRVARGHELKLRLQNGTIFKYDGFQESDQEKLAEFITNNYNLSLDEVELAVKGRNWGSAKFNGTELAFEVDKKPAFHIPLGNVSHSTTAKNEVILEFHQNDDTEVSLMEMRFYVPPTESDTKAAEAFHEKILAKADIIQATGESIASLEQIPCLTPRGRYDIKIFPTFLQLHGKTFDYKIPFTTVLRLFLLPHKDNRQMYFVISLDPPIVQGQTRYHFLILSFNKEEDMSLDLNLTEEEIEEKYKGKLQKHMTGPSFEIVSRLMKSLSARKITIPGSFTGRSGTQTVSCSYRSNSGFLYPLERGFIYVHKPPIHIRFEEIACVNFARGTGSSRYFDFEIETRNGNVFVFSSIEKDEYSPLFDFVSNKKLRVKNRGGNIKDGKSVNYEDMVDSDDDEDTHDAYLEQMKAEGRERVVEEPDEDYVVDMDSDASDSDFNPGESGSDVAEEYDSNPSTSDSDSSSGSDSSEVEEGELKRKKHRDSKPKKKVKTVSERPRKKRKEKKEKDPNMPKRPSSAYMIWLTEHREQIKERYPGISVTEVSKKAGEMWNKLEDKTEWQEKAVIAKEAYTKQMAAYKETLKEDGPPVQKKTATKQPKTKTKTKSKSKSSDSASSPSKKPSSAGSGGNYKSKEYISDSSSSGGEEDDEEDEEDAKSGAKSDASEEVASDPASSEEEKEASGGSDEEEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGK3</accession>
    <name>A0A914BGK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075026.1">
        <property type="nucleotide sequence ID" value="XM_038219098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219098.1">
        <property type="protein sequence ID" value="XP_038075026.1"/>
        <property type="gene ID" value="LOC119742870"/>
    </dbReference>
    <dbReference type="GeneID" id="119742870"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="56324" checksum="40B5F6788E2D6140" modified="2023-02-22" version="1">MTMATAFSPDGSEVIQRSIEVNIAKASSETDLYSVYEIPRCVEFIRKNVFIKVALQFPDELLLDSTSIVKFLQQETDALVFILADTSYGSCCVDEIAAQHANADSIIHFGRACLSPTSRLPVLYIFGQRPIDEDHCCQIFQEFFADGSQPVIVMYDVVYAHCIDSLTKRLTETLLSVVLSRILDPGVDFERNNLTDSRTSNGNDDDGTDIDLALLTNSNTYFQFGRRFTIGRQHALEDYAVFYVGAPTSTLTNLMMTYNRCPFFTYDPEHRQGLRETLNVNRQLMKRYYLIERARDANVVGIVAGTLGVKDYLAVIDRLKTLLKKAGKKTYTFVVGKLNVAKLANFMEVDIYVLVSCPENSLIDSQEFYKPVVTPFEMEIACNRAREWTGEYITDFRQILPGAAKHVELPADDTTEQDSTTDVSLVTGKLRSLGKTQESSETTASKVLVRRDETTTVGTVHANASEFLAGRSWQGLEQQLGQTPVSKVVEGRTGIAASYSEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH01</accession>
    <name>A0A914BH01_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075364.1">
        <property type="nucleotide sequence ID" value="XM_038219436.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075365.1">
        <property type="nucleotide sequence ID" value="XM_038219437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219436.1">
        <property type="protein sequence ID" value="XP_038075364.1"/>
        <property type="gene ID" value="LOC119743088"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219437.1">
        <property type="protein sequence ID" value="XP_038075365.1"/>
        <property type="gene ID" value="LOC119743088"/>
    </dbReference>
    <dbReference type="GeneID" id="119743088"/>
    <dbReference type="OMA" id="CGMEETE"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="13"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="498" mass="53318" checksum="33CA7F872163275A" modified="2023-02-22" version="1">MGCLPQARCRWWRYVVPFLFFVNFFLCPGLLFNYSILFVSLQDEFQSGSTLTGWLGSLSIALLCLLSPVSNLLHPKLSRRAVALVGMTVYCAGLFLTSLVPALGYAFVTYGVLTGVGGNLVVSASIGMTLDWFVTGNYSRAAAIGFTGSTCGMLSFSPLLTAAITRYGWRGALRLFSGGILAVGTLTGLLFAEPPTAEAEGQNDSVVKDTSQDHKNSADTEVAMQQIRAGGMEESGYSEVQGTESTDPDPLDLHDDDKDQGEVDKTEATEADDTSAPREEPVYVDTAISYGYLAMMKDPEQWLWSIGNLLAFLGVTFFNINFASFLDGLHFDDNQIASSIVIFASGELGGKVLISVVGDWLPFSYLYVLAGSTLLCTVTLGLLSIAKTYTAIAVLAVVSGFLRAGVYSTSLVVATELFHKTYGTSGSLTLFMFPVGVGTLASGLLSGILYDISGDYVLSLIVIAAIFLCGSTALLAIPLRRRIRSRGLCTHETHSIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHZ4</accession>
    <name>A0A914BHZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mucin-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075520.1">
        <property type="nucleotide sequence ID" value="XM_038219592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219592.1">
        <property type="protein sequence ID" value="XP_038075520.1"/>
        <property type="gene ID" value="LOC119743209"/>
    </dbReference>
    <dbReference type="GeneID" id="119743209"/>
    <dbReference type="OMA" id="WPTVTNT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037965543" description="Mucin-2-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="67540" checksum="6A67E2E9287C62D5" modified="2023-02-22" version="1">MAPACTSPWTYAPCATVLLCTLLATSWIASITADDVFLFGYDMGDMVCGTIYCNGTEYGSSCSQNASVPNFTDVILPNSLFTKCEDTITTMEPTSLEPTTTMEPTTTIEPTTTLDPTTTMEPTTTMEPTTTMEPTTTMEPTTTMEPTTTFDPTTTMEPTTTMEPTTTIDPTTTMEPTTTMEPTTTIDPTTTMEPTTTLEPTTTMEPTTTLEPTTTMEPTTTLEPTTTMELTTTLEPTTTLEPTTTMELTTTLEPTTTLEPTTTMEPTTTLEPTTTLEPTTTMEPTTTLEPTTTMEPSTTLEPTTTMELTTTMEPTTTSNPTTHLTTTLELTTLHATTTIDLTTTNDPTTTREPTTTQNPTTTIEPTTTDDPTTTRMHTTLEPTNTVTELKTLDPTTTIQATTPYPTTLTPTTLKSTTQEATTTQIPTTQDPTTTLDPTTTTLQQTTLKSTTQQPTTLKPTTADPTTLEPTTLDPTTVKPTTRNPTTYKPTTWDPTTPVGPTTLKPTSPATTTQMPTTKDPTTTQNPATTANPVTTDSPIMPLTDAEIGSISFAAVAVFACVVVYAGLAMMMMMSKSGPPPQVANANTQPAARLPDVNFMRGHGDGQNMLWRTNLSPSASPNTPFGDFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ66</accession>
    <name>A0A914BJ66_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076318.1">
        <property type="nucleotide sequence ID" value="XM_038220390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220390.1">
        <property type="protein sequence ID" value="XP_038076318.1"/>
        <property type="gene ID" value="LOC119744458"/>
    </dbReference>
    <dbReference type="GeneID" id="119744458"/>
    <dbReference type="OMA" id="RWYAREC"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036838902" evidence="5">
        <location>
            <begin position="29"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="822" mass="91249" checksum="A0B6D46351A77030" modified="2023-02-22" version="1">MAGFVSDLNSGTLLWCVVSLVFLTSVATDTCPDSCRCHGNSLKCTPDVNGGTRLLKVPPDLLRYNMFHIKYANLSRNELQQIEPGDFYGLPRVIRLDLRHNRLRALLRNGFSGLEDLTKLELSYNIIRYIDRFAFEGLPNVHKIDLSNNEIAFLEDDSFNTKNGLGSLLSLDLSFNKIHDLDGRTFLGLESLRELYLNHNAMRYIRTDVFTPFENLELIYLGGNFINCTCDWLKVFDNLQSRDIEIMDTSDALRTCTDNALTCDTELEPGDYSDEDTDIQRVATNLTLEDLRPPETDRHGNIVSADGNSFPPWSVEGERVLSTHDAEMRRRIGEVEDRDRRRVFTVVFQERMRGFLKRMMDRGNWLTTTARATTGGNSEEYTVVQITNITKHSENNVTNTTLHPSDAKMDKVVADARIVIKDVLQLLFPPGGFFNASEISRKAPIGPSGIPDPVRVILGQVAEARRAVAELKQRRAALSTPKPSALAPTTSSKSGHTTTRSVHPLTMGTRLPQSALSRPEIEIPFFAVIGIFVFVCIAAGAIAMFSGLCRDKAQCCQCSCLSAISEKLTMRKQQIERQSRKTTAAKSDFIKMHCLAKHTTDSSVKSTSPDKMPTQLAADEHGVVSVTPLVLTDEFPDESGTTPPKSQPGQRKTSTGLLGYIKNRLSSTNKDAALKEAPETSPRDEITLFDISVHGSTSEPLKSTTGTRDARDERDGLPVRSTDARAEKPKLPANQTAESKTPVGASFLACDTTKENVDEKPLASAIESDDKIDVKETSSDLRWYARECLSNQRMMTQARTQSMTSSNGQTVKKGDSEEDGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ97</accession>
    <name>A0A914BJ97_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075517.1">
        <property type="nucleotide sequence ID" value="XM_038219589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219589.1">
        <property type="protein sequence ID" value="XP_038075517.1"/>
        <property type="gene ID" value="LOC119743206"/>
    </dbReference>
    <dbReference type="GeneID" id="119743206"/>
    <dbReference type="OMA" id="DNECCAS"/>
    <dbReference type="OrthoDB" id="6359792at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF6">
        <property type="entry name" value="DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="8">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="28532" checksum="2CA2089D5B7039DE" modified="2023-02-22" version="1">MIFQRGNCTTHPPSRKIGDVTLVVNTTIDSARGEDGVMITFQTEVKPPPNAKVCKTDKNCDKQQFCHREIFLGFDLSYCMACSKNGDRCHADSHCCDKSLCRWGRCREGATSGQIGTICVKDSGCGENECCALVEGIDEAICRPLATEGQHCCSKDEAENLKKGNKKNKSSLSLFEKFIQERSIPYQGLPFECLCIKGLKCVNYGQTFVSVFDLPEAQYGGVCVPGWAQPDRPVAPTLDEISRLQAEKIEDVIGGKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL20</accession>
    <name>A0A914BL20_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076167.1">
        <property type="nucleotide sequence ID" value="XM_038220239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220239.1">
        <property type="protein sequence ID" value="XP_038076167.1"/>
        <property type="gene ID" value="LOC119744357"/>
    </dbReference>
    <dbReference type="GeneID" id="119744357"/>
    <dbReference type="OMA" id="RIINITW"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008336">
        <property type="term" value="F:gamma-butyrobetaine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="114"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45401" checksum="D7AC5592E08EF125" modified="2023-02-22" version="1">MEPNPRLTKITKDDCARWYRVCTDNGFEGTIPYVWLRDNCRCSECFYPSASQRLMKMTDLDPDVIPSSETIVDDGRVLRVIWPDQHRSDFQAAWLSRRHFSDRPRDVVTDPELQSWGAELNGNIPTFDFQKLLEDGAELYNWLDVLNTKGLGLVKGAPTKKGTLRQLAERVAYFKKTLWGEEFQVVSQPNASDLAYTGKTLGFHVDQPYLSYYPGIQMLHCLRRTVDVEGGENQFVDGLHVAQQIQREFPEAYKTLTTQDVDVACATFEDHRQLRLKRRSPTINFDKNGRFRSINYHDGSRAPYQTQVAVEQVTGLYRALKLFSNVMYRPENVVRHQLAEGEIATFNNTRVLHARSAFTITGDGGRHLEGGYMDWDEARSRMRGLRENLFGDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLY7</accession>
    <name>A0A914BLY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076945.1">
        <property type="nucleotide sequence ID" value="XM_038221017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221017.1">
        <property type="protein sequence ID" value="XP_038076945.1"/>
        <property type="gene ID" value="LOC119744844"/>
    </dbReference>
    <dbReference type="GeneID" id="119744844"/>
    <dbReference type="OMA" id="ELIQCIW"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="275"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="51730" checksum="8BA3886C2D8F6F1A" modified="2023-02-22" version="1">MHCTLHLQLNHSIRDRTSQTLLFMSNKQPKPVLTGQRIRTRKRDEKEKYHPNGFSEILVNGLNDVNVNDLEEVAKYLDGAGSKLDYKRYWETLFDILLAGGILAPGGNLLQDDDKKETAISKFCLFSAEETTEAIKGVATVFQRLTRRYRYLGKKLEDDEMKKILSFLKSFSPSERNKLAMFTGLFLSTGESPANCLESLMNETLVKEGISLEFFKVMFRTWLGEKDMSSIAKVLRKASMDRRLLEVIPSTKRTEAYFEKYFAEAGLDQLVTFQRNLQHDDNKNVFMTELKELLEKESPPTPKELIAICTEMQAKTLLTEPEVANLIWNCIMDIVEWNKREELITEQALRHIKPYTPILAGFTSQASTELSLLYEIQEYCYTNINFMKTFQKIVFLLYRTDVLSEETILKWNKEFQVGKGKSVFLTHMKQFVEWLENAEEESDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM20</accession>
    <name>A0A914BM20_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076517.1">
        <property type="nucleotide sequence ID" value="XM_038220589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220589.1">
        <property type="protein sequence ID" value="XP_038076517.1"/>
        <property type="gene ID" value="LOC119744586"/>
    </dbReference>
    <dbReference type="GeneID" id="119744586"/>
    <dbReference type="OMA" id="YYHDRTI"/>
    <dbReference type="OrthoDB" id="10051937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="498" mass="55185" checksum="8F616C8BF90395BA" modified="2023-02-22" version="1">MLSSSPATDSTPDPKTPPTLGETAYRTLPNFYRTTIQLSTLLDVEQPLGHDYRAVLEELGFQPEEVRFWGCKCKRPTLEALVEWDGTVQELADALRVCERYDALSVLVQSLVQIVQQAHKQTDRTGTNILTRDVFPSNSFPELQPSTLRWADPGTCAETFLPEYKQRPDVLNDATSRTSSLSDKLSPDSVFGGVTTELNPSPESLNPARGLSTHRVCTSESPSIASKTRGPADVDALLAAHFEIPVQVVATCLSSSKGRKTTEFVCNLVASAASRCRCISNSGDLTWISNTTVYVNNFARLLLLLVAFLNAVTCVFGPTHTPAYVMELIIAAVPVAQSLYVDQNLPVYRDLIRKIKEVEAGMRLITNCLERAPGKSLTSESNRLTELDARKRKFEHLKSQVLPVYSDIRLCIISTLVVEVSLIFLLLFVGLMCYTGQEILAKFGDGFTLMALALMCIDCAYNFAIVAVYYHDRTIETVLHKDRFRVNADLLRQESDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM22</accession>
    <name>A0A914BM22_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077169.1">
        <property type="nucleotide sequence ID" value="XM_038221241.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077176.1">
        <property type="nucleotide sequence ID" value="XM_038221248.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221241.1">
        <property type="protein sequence ID" value="XP_038077169.1"/>
        <property type="gene ID" value="LOC119745014"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221248.1">
        <property type="protein sequence ID" value="XP_038077176.1"/>
        <property type="gene ID" value="LOC119745014"/>
    </dbReference>
    <dbReference type="GeneID" id="119745014"/>
    <dbReference type="OMA" id="PYHTSQK"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000032">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056370">
        <property type="entry name" value="Shg-like_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF432">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24811">
        <property type="entry name" value="Ig_Shg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="2738"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="226"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="346"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="445"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="543"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="657"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="760"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="849"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="954"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1055"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1165"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1279"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1379"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1488"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1599"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1710"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="22">
        <location>
            <begin position="1822"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="2193"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="2230"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="2425"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="2466"/>
            <end position="2646"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="2648"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="2687"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2812"/>
            <end position="2917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2874"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2220"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2434"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2453"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2713"/>
            <end position="2722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2917" mass="317355" checksum="C6B1C7289E15E456" modified="2023-02-22" version="1">MAAAVRLFATLLNISIILVLILILVSGFALPSINVHFNTRPGTILTELQNQGQSFELDPTSSKYFGVTDSGKLVTNRPLVDLLGSSLTVGIRHRIGDHSWNEQINVRIVNTGRDSKLHFADSRYQGVITENNPLGEKVRGLSDLRVVVPIYAQGMPVQYELLGQGSDKFHLEVSEDDSTVGVYADAPLQVAEKEFYKLTLEAVVNDEVAMTEVQIWVLGLHPPVFAFSSFIYSIAENSPVGTIAGTVFATDEDMGENGHVTYHLLKPNRYFTVGQESGLVTVTETTPIGEYKMQVVARDAGTPFQESAPVPLQISVISSSSNMIPYGNDMMFAPDYKPSKRFRREVLPEERVPVNEDTAIDTVIFTVSSLNDTDRFAYVGTPNPLFGLNETTGEVTLLGQLNFEQATVHEFEVEITNVENTDKRDTQRIIIEVQNVNEPPQWEIVVYPYIAVVPVDASTGASIYRLRASDPEGSDVRFYLNSGGSGLFTVDEESGSIRTSLLEGQTYEQGRKYILSVYAQDENGSSIPAEVNIFGGSHPPQFTQEVYNVAVEEEKIGEQNVIDIDAFSFSNVAVTFALLNSETNQPIPRHSIDPSSGLIKLLENVDREVLDSYFLEVQATEDVQDGLSTTVRVNVEVTDINDCVPKFERETYSFRNVIETIDTTTPIGTVAATDCDADPNNILTYSLIGAQADKFRLDSQGVLYAATGLDYDVGDGSYELEAQVQDQAGGADTAKVWVYLTDVNDEPPVFLNTDGSVYYIDEDAPAGYIIGTVYASDADKTDTITFGIQGSSTFQIDPQTGVISRIGTGNLPEASYRFNVTATDGKYTSDAEVEIQVNDINDNTPVFPDCSTYTPSISESAGIGTFLIKVQATDADKGVNAEIAYDIAGSNNPFTIDAVTGDISTQDPLDRETTPTIDIVVTAQDNPGSIFSNQGFCFITVTITDVNDNRPTFPLEDYVVIISNTVQPFTTILTVQVEDADLPTPAGFTYGLTGQNPVLFEIDQDGEISPVADLSGYDDNTFNFKVEAEDGPNKAKSNVQVKVLATGVDQPPVWVSTFPDITVMENISINDVIGTLEARSQSGNGVGYRVVQGQIPQTNSEGQFAVQNVGDSMIANLYISAPLDYETTKFYKLQMEAYDDGNRLSILGTQTVNVQDVNDETPQFPVTNFFVAYPEDVDPPFLVTQVQAEDADTEPAFKTITYSLDPSFSDAPYFSINPTTGALTSLIKFDRESEDSYSVQVVATDGAPSSLPSAGGPNKGYLRVVINVVDKNDNPPVFDAPMYIRTIREDEPVGSEVIQVTATDVDPDSIPRYLITANNTGGAFEVDPATGAISIASPLDYETQREYWLMYTANDGLNVASTVIRIQLENVNDEKPEFEAPVYTAEVSENDPNVPRQLLQVKAVDGDADANQADIRYSLEGTGAGTTFTIDAVTGQITLTEMLDRESVSIWKLLVKATDGGSTGTSLTGYADLEVTVLDENDNSPFFPELEYRGSVPENSPGGTRVMQVTAIDYDDPNGFGRITYSTISSSEIPNDGSGLFQIDGSTGWVTVKSGAVLDREKNDTYTLRIRASDVPNSEALTDAIIQILDVNDNAPEFVGGPYATSVEETQPVGATVWEVSVTDADVDFNEEVQFNIIGGNVGGSFEIVADPLTLIGIIRIARQLDYESPNKLYTLTLTVDDNSGPDSQSQTTITIDVLDVNDIAPTFNPAEYVSANVLESVAVGTYIGTVSASDPEAGLFGQFTFSIDPASDPDGLFSIEEILPVGAVKRADVQTAKPLDREKVETHVLTLRATDLGVPPLTGYATLNLTLDDVNDTPPTFATDYRPTIKENLAVVQFVGYISAKDEDPTGGPPFTLVVEPNTDTNSFTWFDVDGLTGNNLSISSKAISFDREAQATYSIPIRITDKAPNGNSGVQNLIVEIEDENDNQHYGTTKEMLVYSFEGDIPETRIGNIPDSPIGFVGVSDKDTLEDKTYFPDLSDVYKQYFRVDEDTGQVTILAGTPAGTYNFDVRVADDGKYDDQTSTVIVDVRDIPEEAVRSSGSFRFEGVTAEELITVPSGGGETKLDILKNILAEIIPAKPENVDIFSVINVPNQPNTVDVRYSAHGSPYYPPEQMDGAALANRDGIAQALGVTIGMIKIDMCLLESACESACTNVLEIDPQPTLINTPSASFTAVTTSTVAKCVCGANTQQPGLCDFDACLNGGTCTETQGGGHTCQCPTGYDGPDCQQTTREFKDGFAHFGTLQQCEETHTSLEFITTAAEGVLLYNGPMIPVTGDMPEDFMLIQLLGGQPKLEINLGSGTLSLSLPATTNLGDGKWHRLDVYRNGKDVEFMLDRCKDAAVAEASTSSSRQTDQCKITGQAPGDNKFLNVNTPLQLGGIDESPGFTYPVDITFAASYDGCMKNLEQDSTLYDLETPGKAAGSEAGCSKLVCGECNNGTCEGDFSTYTCLCDPGYTGEKCDQTTPAYDFATESYVRYQLKPTIVIDSREGNYQVSFRTREDEGLLWTITNLNGLEFTTLELINGYIRSRWNLGDGEHSMYLDQYAVNDGDWHMVHLERFDFYITVRIDGGGGVRQMESRESTFSTLEVDPNSLLLGAFVVHVVDISQDFQGCMNDPRINNFYLGFETESDYAIPQPTASVTEGCPSYDPCASNPCPVPFICKDVWRKYICICKPGFEELGNTCVAIDDCDPNPCLNGGICTDRESGFDCECPDGYRGDICDVKVVPRVGEPLNLSIGAILAMILCILIIILMLLAFVFYKRNQDRKQALAFAIDPDDDIRENFINYDEEGGGEEDQDAYDVSTLRKPVQPVQPMDDYIKPPTTVVPLSHAPRPTGDDPNVGDFINDRLKDANDDPDAYPNDSLKEFDYEGEGSSAGSLSSLNSSSTDGDQNYDYLNDWGPPFKKLADMYGGGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM52</accession>
    <name>A0A914BM52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077199.1">
        <property type="nucleotide sequence ID" value="XM_038221271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221271.1">
        <property type="protein sequence ID" value="XP_038077199.1"/>
        <property type="gene ID" value="LOC119745047"/>
    </dbReference>
    <dbReference type="GeneID" id="119745047"/>
    <dbReference type="OMA" id="WPRITED"/>
    <dbReference type="OrthoDB" id="10053647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="108"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="229" mass="26129" checksum="800C63EEE1D176CB" modified="2023-02-22" version="1">MVITRWPSNKQEVPLCIREYWPYRDELATQNGIIFRGTRVVIPTNMRRDLIVRAHASHLGTQSTINKAREIMFWPHMSQELTEAIQKCPSCQEAQPANCKEPLMTHPLPTVPWQVVATDCFELDGQSYCVFVDLYSDFIEVVELENMTTETLVKKTKPVFATHGILATLISDNGPNLASREFSQFAREWDFRHITISPHLSRANGKAESAVKIAKGLIKRSKRDGGDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNP2</accession>
    <name>A0A914BNP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077107.1">
        <property type="nucleotide sequence ID" value="XM_038221179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221179.1">
        <property type="protein sequence ID" value="XP_038077107.1"/>
        <property type="gene ID" value="LOC119744955"/>
    </dbReference>
    <dbReference type="GeneID" id="119744955"/>
    <dbReference type="OMA" id="PAYEVYV"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051887">
        <property type="entry name" value="GH18_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290:SF1">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961937" description="GH18 domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="240" mass="26670" checksum="0B9A03915857CE39" modified="2023-02-22" version="1">MVSGRRLRVLSGILPALWLLCLCLRHGTTAPVKVDCPCADPSQCELITAPPRKELFAFIVEDSNWQKYDWSKITTVGLYTKYDPKLMCHAHSKGARIVLAVIYPVDNLTNPAARTAWIQQQVAQAKSWHMDGVNFDIEYPVSIEDAHYVVDLVKETAQAFKAYNPNAQITFDVGGVPPCLVLGWCYDYTALAEACDFLFLMDYDLLAAGPVAFPNSPLSVIKFAANGSVYIPEGIYRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTB9</accession>
    <name>A0A914BTB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079235.1">
        <property type="nucleotide sequence ID" value="XM_038223307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223307.1">
        <property type="protein sequence ID" value="XP_038079235.1"/>
        <property type="gene ID" value="LOC119746393"/>
    </dbReference>
    <dbReference type="GeneID" id="119746393"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037471772" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="106"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="237" mass="24997" checksum="30B17A5C39DA2CEE" modified="2023-02-22" version="1">MKICLATILSIALLLGNSVKLRASVTRPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPVGPIGPYGQPGSKGDAGPRGMPGIVGRIGETGVKGQKGEPGETPDDSNQRVAFTVVRTSSSDESTSQDSRLPFHQTETLLPGTSFDLETGTFTCRVPGTYVFTFSVLKNSNSGNLHVNLVKNNYKVISTYGETSQRGQLSGSAVLILQRADTLYLTMYGRAHSHPTYHWTSFSGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTM6</accession>
    <name>A0A914BTM6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079408.1">
        <property type="nucleotide sequence ID" value="XM_038223480.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079409.1">
        <property type="nucleotide sequence ID" value="XM_038223481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079410.1">
        <property type="nucleotide sequence ID" value="XM_038223482.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079411.1">
        <property type="nucleotide sequence ID" value="XM_038223483.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079412.1">
        <property type="nucleotide sequence ID" value="XM_038223484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223480.1">
        <property type="protein sequence ID" value="XP_038079408.1"/>
        <property type="gene ID" value="LOC119746507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223481.1">
        <property type="protein sequence ID" value="XP_038079409.1"/>
        <property type="gene ID" value="LOC119746507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223482.1">
        <property type="protein sequence ID" value="XP_038079410.1"/>
        <property type="gene ID" value="LOC119746507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223483.1">
        <property type="protein sequence ID" value="XP_038079411.1"/>
        <property type="gene ID" value="LOC119746507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223484.1">
        <property type="protein sequence ID" value="XP_038079412.1"/>
        <property type="gene ID" value="LOC119746507"/>
    </dbReference>
    <dbReference type="GeneID" id="119746507"/>
    <dbReference type="OMA" id="EMEIVHA"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="335"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1043" mass="119843" checksum="8D368494DEF0A1B6" modified="2023-02-22" version="1">MGCGASRSLDYSSEISQQWDSVNKTIEVKQQSKKLVIKRVGWKTVRIFVSSTFRDFHAEREVLIKEVFPDLRAWCEKRRLYLVDVDLRWGVPKDTTSEDTLRMCLGEIDRCYADNIMPFFLNMTSERCGWIPGLGEVPENLQQEYRWISGLSVTEMEIMHGAYRKDNYNSIFAMRDATFLGTLPEKYHNDFVDSNPVASQKLKMLKDMLTDRFPMNGCSSSPHPSSLFSSDSSSLTSMDNRVFKYHCKFGGIDVDTGKVQMEGLDDFKKKIFEFFKMRVEEQYPLDENAKLDPYEQQREAHDAFMKSRSAIVIGRNDILQKMEDFVTDISTGVPLLLLGGPGSGKSSIMARVADVAVNKAGSGEIPGGGDKGWHIFYHFVGAIPGSTDIEKMLKRLLRELKMCNDSNMPKDYETAAQLVGSVLSNPNSKPVIIIIDALNQLNEDKTASILSWLPRKLAPQVRCIFSMIDDTPPHRLLKDRNVKPDEVAVTPLDIDSRKEIVREILGRYNKRLDAEQMASLLGKDSSQNPLWLAIACEELRVYGDFRTITKKINSLSDGLLNLLGQVLTRFEQENGGHLVVATLSLLECSSNGLLETELLSILGDEENMSILTKKFFKTKDRGKEKTRGEPLPAVKWSAVYRALRPFLRPFGDSGEGRLDFYHRSLSKAVRQKYFGLKPGEEAGSDKLSKWWHQKLAEFFEHEQNMDRKVEEYPYQLVKTHDQERLARCLTEWPMLDRLFDEEYSSQLLAYWREIDKDGKYTKMEESYRASLKELEAREGISQEEISLRNETIAKVFIQAGLYNHAKDLIDKAVSLEQEHLGSRPERMVELYAIMALLYDELCKLHDFITREQLKELRPAIDFGRRSIKIRETLEGERHKYKMADSVMRLSFNLNNWSECNGDSTLSAEEAQDESVVQADEAIRLFKEIGDLGKEAEASMTKAIVFPRGEPEQIEWYELSREQCQQAYGENCKLMTRIMSNIGIYYEDRREFDTAYDYFAQWYEISREVFGEQHPKTISANSCINEPRYRQIRARKEAAAQGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXP0</accession>
    <name>A0A913YXP0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044137.1">
        <property type="nucleotide sequence ID" value="XM_038188209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044138.1">
        <property type="nucleotide sequence ID" value="XM_038188210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXP0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188209.1">
        <property type="protein sequence ID" value="XP_038044137.1"/>
        <property type="gene ID" value="LOC119718787"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188210.1">
        <property type="protein sequence ID" value="XP_038044138.1"/>
        <property type="gene ID" value="LOC119718787"/>
    </dbReference>
    <dbReference type="GeneID" id="119718787"/>
    <dbReference type="CTD" id="11169"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21993">
        <property type="entry name" value="HMG-box_WDHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055339">
        <property type="entry name" value="HMG-box_WDHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1128" mass="124800" checksum="C55E5E997A212D69" modified="2023-02-22" version="1">MPLNKQEMRMGHSEGQTDVCYEETGNHILTCGSDGDVRIWKSMDDDDPESINVGDAAYAIAMKNNRLYTASEANTIQAHTFPEGSADGIVTRFTAPVTHFCLSEDGEKLLAGASDFTLKYVDIEGSNQKSFHGHNAPVLSVAIDPKHEYIASSSCDGTLKIWSIADQSWEKSVSLIPKCSDVSLSKTLCRLSWKPQVGKFLAVPVEKEIHIYERDSWDLAFTLTPQDVTGFISVTAWSPCGHFMASANTDGHICIWDVNTRECIDRTKHNKGLAICGMAWHPANGNEIAYTDVMGQVGVLDNVIPPDRKTTTQVQVFKQSADLFDDDAVDEDFLDAVTQAEVENAAGKPTNEGEDGDDVMPATQHKRIMQIQDDDNSMDGSSRAGDDGASVMSGTMDTMVPQPTTYEGPKPTPLQKPFIPAATPVHLASRFMKWNSIGIIRCYDTEDESSIDVEFHDTSVHHAMHFDNQLNRTMADLSAEAVLLGSETNGDVPSQLVCYHFASWDNQKEWTTSLPKGENIKCLTLGRGWLAVATDKRLVRLFSIGGMQREILAIPGPVVCLAGHGNQLIIVYHAGTGVPGEQCLGVQLLHIGGKRKRCVVSGDRLPVSPKATLAWLGFSAEGTPCTVDSEGVVRLLNRSLLSWIQISNTKNHSKSRSDHFWVVGLNESPQQLRCIQCKGAAFPPTLPRPSIMVLPFQVPLCDLDTEKGIMEEAYWRADALSKHIEYGASQGYEIDEMSQAQTDREKQENIMKLFALACRTDREYRASEICQLMTSQHAVTLAIKYASRSRRMALAERLNQLAQQMMEEEMAAMETEQEEEEHDGYYSNATTTKRSSSSTEWSTLSRSKAPTHQASRQDDEDDNEEAQEEEVAMEDDECDDDDDGMPEMKSRKVPTILIKPKKDGVITSALPSSQTRKNPFKRSSSESQVASKGSSVFDSMKKLTKLKAKSPPEKPSEPKQKKGKTQSTLFGNMKSPRQKEKDESNKEGTEQTMPVNKPPSAFSYWLTENQASLAEETPELSESDLIKLATQKWRSLPAEEKKDWGAKAKRSVQSLEADTDPKENAAQETTELTEGKKRKLPHDGEVTQGSEKRVKGQIKVKGQDSSIVKRPLLSSTNSKLAGFAFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY80</accession>
    <name>A0A913YY80_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transformation/transcription domain-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044321.1">
        <property type="nucleotide sequence ID" value="XM_038188393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044322.1">
        <property type="nucleotide sequence ID" value="XM_038188394.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188393.1">
        <property type="protein sequence ID" value="XP_038044321.1"/>
        <property type="gene ID" value="LOC119719084"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188394.1">
        <property type="protein sequence ID" value="XP_038044322.1"/>
        <property type="gene ID" value="LOC119719084"/>
    </dbReference>
    <dbReference type="GeneID" id="119719084"/>
    <dbReference type="CTD" id="8295"/>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2706"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3601"/>
            <end position="3922"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3926"/>
            <end position="3958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2050"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3323"/>
            <end position="3390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2086"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3334"/>
            <end position="3387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3958" mass="446305" checksum="656711F09FF97903" modified="2023-02-22" version="1">MLQSKPAVVTMPIASGSSPIDPATIINKYRTNVSILADTRTVDDNRLKAAQEISENFEVILSSSQNGAFLEFAIPLFLRVLKEEKPYFIAEKAQQHLRKLLLELLHRVPTNETLRPYVPAILELMFSLLERENEENVLVALRIIIELHKHYRPALQPEIHNFLQFVKNKYKEIPTNLKSLDPGSSVSPPDPLNILPFVDRPGFACQTIITVSQPDGTKSQQTILPKGINSLKVLAEYPFIVLLMYQLYKQSVHTVVADFIPLIMNTITIQPNAQARLSPTFNKEMYVDFIAAQIKTLSFLAYILRIYQEIVNSYAPQLVKGMLGLFTNCPSEVAHLRKELLIAARHILATDLRNKFVPTIDKLFDEAILVGSGTTSKESLRPLAYSTLADSVHHLRQHLPLQHLSMAVHLFSKNVHDDSLPCNIQTVSCKLLLNLVECIRQKSEQDGANAREILMHMLQVFVLKFKTISENQLPLIFQKCRQPQDTSQDKSSSSQSHPISSFGSKPPPLTLIIPAAPPTPSTPAPSTPGLLPPPPTPSVPPTPTVPSTPAIPSTPGPGMLPLSSLFPDKDKDDSKAKTYVPSSFSQYSNYSVTDCRNLVKTVVCGVKTITWGVSACKISTDVQTFGQNKQFQPKETAVFVDLVKYAMKALDIYQIQVASNGQTTIRPPAMQGVRIKDEKEVLEHFAGVFTMMHQLTFREIFQTTIDFFVDRIYHNYALQIIANSFLANPATSATFATILVEYLLQRMHEMGTNMDRSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNRSMELATTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPDLLQGLNQLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYEHIQPVRAELMQALWRTLRNRNDNIAHVAFRVLGKFGGGNRKMLKEPQRLTYKDEDSEGPCVTVYFPDHKTHLQLPVCKVVETALNKLKSPSTEPYYRRQAFEVVRHFIISMMNLDDNKQAVHQLLTHSSMTTGDIPRTSSGQVYKCPNTLARTAFQHALTAMIVSAAIKDLRSDSLSFMLSIVRHFTLIAVVQQAGPLPVSNQKNQTAMDPLVLMDAIASCMAYEEKELCKTGHLAMSFVVETAAVVMGSKYRACQLPLFEHMAERMCGCCYERAWYAKLGGCIAIKFMMERMDLCWIQGHLYQFLKALFFVMMDLTGEVSSGALDMAKTNLETLLKLCASPLEGENAENAKLSVAQQKAFHDVTRQLVIEVTSPNETVRHQAMDSLRSLAEITGKKVTDIMEPHREVLADMIPPKKHLLRHQPANAQRGLMESNTFCTTLEPRLFTMDLNIAEHKVFYMELVNLCEVEDAMLTKLPCYKNVPSLVPLRISALNALAACHYIPHVRDKIFKLLYIFLTSKVPELLKAGAECMKKFIAGHAVDMELVHTTIRPLLLKLGDHRSLNLNAIQRLHNLTQLFPNAFNEKLCEQMLTHLKKWMEVSIAAQRSNTSVQTKATESIKICSAIINIFHAIPAASAKLLDALVTLTIKAENALCIEVGSPFREPLMLYLLRYPSQTIDFFLTETNLRNSQFSSLLAYLLKQDEAKPLRDVLQTNTIKLINLAFNKPQPTARPTSPNSQAKLELQYQTILICSILVKHDPAWLPQKSVLFGHLRRIWISDAFQDQHHTDNVGVAHWNEPKMIVECLLNYAEHHPSNVELLFQLLRVFTNRYLPNFQFLRDYLEETVAQGYSVEQKRHVFFKFVELFHEKTFPQELKAKALQFVIIPMFAASFDKGEGEKLIGGPPNPGQDSPDNLVSVFISKVIDPENPYRTSDSVRILLLQFAALLVEKAAPHIHDAADKKQGTKLRRLMTFAWPCLIQKNCVDPTTKYHGHLLLSHNIAKFAIHKRIVLQVFHSLLKAHAVEARVVVRQALDILTPVLPHRMEDGYAMLTHWTKKIIVEEGYTVFQLVHMLTLLVRHHKVYYPVRHHLIQTMVYSIQRLGSTPNTTLEHRKLVVDLVEVIIKWEVQRIKEDDTNSEYPAAPLDETAVTTPGGIKRPASGEHVPDAKRVRHSSGTSVRSISSEASKPIDKIYSDAVVNFLLRVACQVNDLGTTSAGSPGELLSRRCIALLKIALRPDVWPSSELRLNFMDKLFLSVDQPAQANYGNICAGLDMLNFLLGVMTKQVILTSLKPLQRGIAACLTCANTKVIRSVHALLVKLMNTFPTESSTSNVASKYEELECLYASVGKVIYEGLTAYEKAASGTPTTSLFGTLMILKAACTNNIAYIDRLISVFMRALQKMTREHLTPSSSESTSLASELLIISLDLVKNRIGVMSTDMRRNFIQVVLTQLIEKSPDAKVMKTVVKMVEEWVKAKTPLMMNQSPSPREKSVLLVKLMQYVEKRFPDDADLNGHFLELVNWVYRDESLMGSELTSKLEPAFLAGLRCQQPQIHQKFFEVFNGSIKRRLFDRLLYITASQNWEAMSTHYWLKQCIQLIMAVSVNGMSMSCTNTPQLPSISSVIGLADSQDKKTFSLAVTIKEEPMDIDMESHKEEDIEIDIELSHPEGVSTSGGAASVSSKKSSDLKQQLQMLISKDIKFIESLRDAKTFNFLTALSQLCHSDTEMTHQLWVDLFRRLWKILNEKQQTLLAQELSPFLCSGSHLYQKDGTPSVINTFVEAISLCVPPVMLRPCILKYLGRNHNLWHRSALMLEQSAIESGFSTQHRPPRTLNVYDFYEPDNASTTQQETLDSLSEIYERLQEEDMWAGLWQKRCKFPETATAIAYEQQGFYEQAQSAYEGVMSKARAEHNAGPAAPAVFSEYQLWEQHWVRCSRELSQWDLLMDYGNAKGQTNPHLVLESAWRVPNWSAMKEALAQVEQSCPREMNWKVNLYRGFIAICHPDEKNLSMIERLVESSSSQAIKEWRRLPHYVTQAHSPLLQAAQRIIELHEASQIHQGLLPANLGRNQSLHDMKAIVKTWRNRLPMVSDDLTHWSDIFMWRQHHYQAIVSAYDNLNTQDMKSRAGLESNQTSRSALAKEQQQHAMLGVHASAQSIINYGKVARKHHLIGPALDSLSRIHTIPSVPIVDCFQKIRQQVKCYLQMASTMGKQELQEGLEVIESTNLKFFTREMTAEFYALKGMFLAQVGSRSDEANKAFSAAVQMHDTLVKAWALWGDYLEQIYCKDRQTQVGVSAIVCFLHACRHQNETKSRKYLAKVLWLLTYDDDKNSHPLAEAVDKYSVGVPPIQWLPWIPQLLTCLVGSEGDLIINVLMNVGRVYPQALYFPIRTLYLTLKIEHRERFKSGEYIGGLRRNSSVGKAGEGSTQTPAVSTTAQSTSTTSISTITSTATTSTDTNGSSTSTTGHSSSSQLGASSASNPGPIRASVPMVRCSRIMQVQRDLHPILLSSLEGIVDQMVWFRETWNEEVLRQLRLALAKCQAVAFENRGAVVEAKVTPHTLSFIKKLVTTFGVGIENVSSVATTFSSAASESLAKRVQATTQDPVFQKLKPQFTTDFDFSLPGAMKLHNLIFKLKKWIKVMETRSKLLPKFFLIEEYCRFLSNFSSSTADVELPGEYLTPRHSHYSVKIARFMPRVEIVHKHNTAARRLYIRGSNGKIYPYLVVNDASMGESRREERVLQLLRMLNIFLAKRKETAKRQLQFTVPKVVAVSPQMRLIEDTPSSLSLLDIYKQRCAKHQVEYDAPINRYYERLATVQSRGSQASHQVLRDVLKEVQTNTVPKGMLKEWVVQTFPDATDYFAFRKMFTTQLALLGLVEFVMHLTRLNPEIIQVERNSGLLSIFYFRFDMDDATGELDANRPVPFRLTPNIAEFLTTVGVNGVLTACMIASARCFVQPSLQTPSLLRAILRDEMIAWDKKQKQDDASGPGSQPSNMDSEVLISTVNKAASAIMTRLQNLAQFEGGESKVSTLVAAANSPDNLCRMDPAWHPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYW7</accession>
    <name>A0A913YYW7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044758.1">
        <property type="nucleotide sequence ID" value="XM_038188830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYW7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188830.1">
        <property type="protein sequence ID" value="XP_038044758.1"/>
        <property type="gene ID" value="LOC119719391"/>
    </dbReference>
    <dbReference type="GeneID" id="119719391"/>
    <dbReference type="OMA" id="IWTKVPV"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000026">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000030">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF54">
        <property type="entry name" value="PMS1 PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="688"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="688"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117868" checksum="5A0E5AEDFAF09782" modified="2023-02-22" version="1">MACMRKLSSDTIRLVTSSQVITSVVSVIKELIENSLDAGSDNIEIKLENYGFDKIEVRDNGSGIKPIDAPFMARRHFTSKISQHADLEYLATYGFRGEALGSLCAMSSVTIVTKTQDDEFGRHYVLDHEGEIVTSKPSHLGNGTTVTAMHLFKNVPVRKQYYTNAKRRRDELKKVEELVMSYGVIRPAVRFALSHNKSSLWQKCKVANHKAALINTWGSSVMSHMQYIQRLDDETEVRIEGFVPSLSADSQSASRAVSDRCWIAINGRPIIFKDIEKMVKQSYCQAVKHDMVSVRYLVMFISISLPQHHVDVNLEPNKTKVMLQNKEVVFSVLSDLLDEVYGRKADDHIADVVIPNSTHQQANNIQPVDNLPTQLGFNDRTLCNTNTAFEDNHVPTCTSDGGVKNENTWSIEKLDCERESAVYQSINLGKPSHQDHNHDVPVCKATEEPKGIAETPCSAQNVPTTTKNLPSASNDQTVGDSIQQNIFQLNFSIFDDVDFELEKVDETAATIALDEAKCPESDLMNQNVLHQADNTTMCDYLIEETAGNVQSVTSSVNLTDWSKGRGLTNKDGRPLEPATLHIPRKAVEERLVTNHIEPGQLSTNQRTSNSESPFQVPADCTNTNQNKLARIPHTVTLGNSMTSSSSTNQEADDLTPTNGKRTSPKRRPSLEKKIGKGTMYDLICGSPIRRPQSSYEFFCKEMRPLVLGENPRASFNDITKVVAEKWRQLEEMEKAKYEEKSRRDTERHRNQLEAAQKKLGFKRGTGLEAPPSKKRKITLASNQGLIDKMLLSQQQRESANQLLPTKAPDIPTVNITFNLIGLRREFETHQQKRKTDPDQRLNLIGQLASHDVWLAHHGNQVVVFNQYRVEETLLFHRLLAHHMLPCQPVEVPVVLSPSMVGGHDNWATLLEMSKRVNPPDPAMYYTDTRLTANGFTIKQTVDSETVEVKVQVIAMATTVSCYGIQDLQELLELITTKQSCTLSQCRPLKVANYLKGEAVRMARNLPSTMLEEDVQNVIERMKQLPNQCKTCLHNQPFTYPLFVISESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z184</accession>
    <name>A0A913Z184_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044435.1">
        <property type="nucleotide sequence ID" value="XM_038188507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z184"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188507.1">
        <property type="protein sequence ID" value="XP_038044435.1"/>
        <property type="gene ID" value="LOC119719166"/>
    </dbReference>
    <dbReference type="GeneID" id="119719166"/>
    <dbReference type="OMA" id="NILPREC"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="369" mass="41208" checksum="CB6B719751C78FE4" modified="2023-02-22" version="1">MHNGSTTTEGTWFDNCTVESDAGMGIFQSFTQRQILAAILITVAILGTVGNSFVIVAVAWTKKLRTVTNVFVVNLAVADVLTCVFMPWQVVAILGGNAWPIPEAPWLCAMGGFVIVVTFGCSINSLALIAVNRWVGITKSRLTIRRIYTARKLALMVIFSWAIPLGCALTPVLTDLGELGYEKLYSTCTWVIEKSVYYSMFISAMYYPIQLILITVCYTSIFCYVRKTSRRMTRADAPTNSDEVCGQGANRAMRRMLWKRQVDVTKNLLYIVLVFVFCLTPYFVTIIFTSDWSRQLVPWAGAILFCNSCVNPFIYATSHPVFKEAFGYMVRCKKIPISGASYQIRCAATASTDVPDIHTSHTEKYTTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1Q6</accession>
    <name>A0A913Z1Q6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045609.1">
        <property type="nucleotide sequence ID" value="XM_038189681.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045610.1">
        <property type="nucleotide sequence ID" value="XM_038189682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045611.1">
        <property type="nucleotide sequence ID" value="XM_038189683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045612.1">
        <property type="nucleotide sequence ID" value="XM_038189684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1Q6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189681.1">
        <property type="protein sequence ID" value="XP_038045609.1"/>
        <property type="gene ID" value="LOC119720128"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189682.1">
        <property type="protein sequence ID" value="XP_038045610.1"/>
        <property type="gene ID" value="LOC119720128"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189683.1">
        <property type="protein sequence ID" value="XP_038045611.1"/>
        <property type="gene ID" value="LOC119720128"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189684.1">
        <property type="protein sequence ID" value="XP_038045612.1"/>
        <property type="gene ID" value="LOC119720128"/>
    </dbReference>
    <dbReference type="GeneID" id="119720128"/>
    <dbReference type="OMA" id="QKIRRDC"/>
    <dbReference type="OrthoDB" id="2581252at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="113" mass="12803" checksum="88667B06F50CBA33" modified="2023-02-22" version="1">MEAVITLIMKYCGTELDLYGQCVNDHPKDWQTACAELKEKASNCSDHHPVVRQINRDCAVEFSNYDTCLKKNPEDVTVCVDQLHKFLKCADTSAHRIQNAIFEQSKQDGSHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2T9</accession>
    <name>A0A913Z2T9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exocyst complex component Sec10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046148.1">
        <property type="nucleotide sequence ID" value="XM_038190220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2T9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190220.1">
        <property type="protein sequence ID" value="XP_038046148.1"/>
        <property type="gene ID" value="LOC119720519"/>
    </dbReference>
    <dbReference type="GeneID" id="119720519"/>
    <dbReference type="CTD" id="10640"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="158"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="723" mass="83364" checksum="EB60AFD52EBD5EFF" modified="2023-02-22" version="1">MSLKEFESATFDPEQYIEQLAWRTQGGDSKEGPQDFDAKTMLRAFENTIEELKLLSMRMEERTGKLDASIRAETKNHAKRVAQLQENNKMAFLHFQELDEHINKVATNVVHLGDQLEGVNTPRARAEEAKKLIEYFSEFLDDFGPKAEVFNDPFQLQEAADIIQKLQLISQELPQEQFEKPKRRIQDKYNQIEEDLITEFRSAFHEGAVDRMKELAGILTHFKGFHRCIDAFIEESQANTYIFYDVYEDLIPLCKKVNNIVHQVFSSPESVMGKFVLNLYEVKLQEHVKQKLANHEDMEHYLKDLHELYARTGRLTTALSDYRLGSDAHLLSRLTKHIFGSYLQSYIAREEMHLRDRMSENLDNYYKGMNHQKKQIQHTGGLQDLQHKLRTKTTLNIGSSGPQVDFKGETFLSQEIALNLLNESKQAFNRCQLLSNQSDLSPHAIIIFDILIEYLCIDHIDYALEIGLQGIPSSEPKNLPQTYFFNIAGEANAIFHLLEKQFSDVLVPLIRGHTPESVGMCFVSSSPAHSDCVQKKKQTMEQMESKIETGLDRTLATVCGWMKYLLDKEQKKTDFRPESEEGPMRMYSNACAKVIPFIEKQVETIKRCLDGKNITAVLMEFGIRFHRVIYDHLQQFTYNSLGAMLVICDVNEYRRLVKSFKVPMVNSLFEKLHALCNLLVVVPENIKSVITGEQLSGLEKNTMMSFVQLRADFKTAKIAQQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2U4</accession>
    <name>A0A913Z2U4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045311.1">
        <property type="nucleotide sequence ID" value="XM_038189383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2U4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189383.1">
        <property type="protein sequence ID" value="XP_038045311.1"/>
        <property type="gene ID" value="LOC119719912"/>
    </dbReference>
    <dbReference type="GeneID" id="119719912"/>
    <dbReference type="OMA" id="TGNCHKW"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF4">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="104"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="48906" checksum="6DE9B422AD65F468" modified="2023-02-22" version="1">MKPVEVASSVAVGIFSAAGLVWGLQYYSRKRQAAKKAFGRELRQAEYCFAEDFCLCNNGSFAAVPRPILQLQQRLIAERERKPALWYRRQYDPKWFPSEGGHNRYAQAVMAVAEFVGAKSENLVLVENTTTGINCVLQNLPLTKGDKILLTTHGYGSFIKTVQYVCEKTGSEAVVLEIPVPIESEDDIVKLYADALEQHSNIKVAVIDHITCPSAILMPMERLAALCQQKDVLVLVDGAHAPGQVPLNLEQLPVDFYVGNLHKWLFSPRGCALLWVHPSHHDSIRHVITSHSTYAPTLMERFCFIGTRDNIPYYCATAAIKFHHDLGGLEAITAYNASLCGWAADMLAKAWSTEQLAIPAHMRAPFMAIVAVPETDAYPACPESCGKLMGAVFSHSGVIAAFSHFNERLWCRLSSHVYNCQDDYYKLRDAVLQVMQIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2U8</accession>
    <name>A0A913Z2U8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046158.1">
        <property type="nucleotide sequence ID" value="XM_038190230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2U8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190230.1">
        <property type="protein sequence ID" value="XP_038046158.1"/>
        <property type="gene ID" value="LOC119720529"/>
    </dbReference>
    <dbReference type="GeneID" id="119720529"/>
    <dbReference type="OMA" id="FYECHYP"/>
    <dbReference type="OrthoDB" id="2951111at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032978">
        <property type="entry name" value="ZMYND19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="232" mass="26796" checksum="1CBE0C2030233C49" modified="2023-02-22" version="1">MSAFKLGIVRLGRAAGKMKYSLLDEQDISLVERYAFEARVDVCKDGNGASVFAYTYDVQKGRNSGCYLHDLLWERHHGPIPAGLRVKHKNGVSVDNRLDNLQLTVINPSSNSSTEERHRVLRGAELQEHSLYWIAIQQLPTDSFEEVPSVLHHYFNANGEIIEGEDESTTYFECHYPPCTKIESELREFSICGRCQEVRYCGTTCQQRDWTLHKKRCRERKKSKPYERPPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z398</accession>
    <name>A0A913Z398_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 180-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046308.1">
        <property type="nucleotide sequence ID" value="XM_038190380.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190380.1">
        <property type="protein sequence ID" value="XP_038046308.1"/>
        <property type="gene ID" value="LOC119720631"/>
    </dbReference>
    <dbReference type="GeneID" id="119720631"/>
    <dbReference type="CTD" id="100499483"/>
    <dbReference type="OMA" id="FQEEQNM"/>
    <dbReference type="OrthoDB" id="431588at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028089">
        <property type="entry name" value="DUF4455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14643">
        <property type="entry name" value="DUF4455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4455" evidence="3">
        <location>
            <begin position="132"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4456" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="832"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1581" mass="180912" checksum="A620BF82D7595A7F" modified="2023-02-22" version="1">MAETQARPLRVVPSGKIYRQIFDAEVQLVNTLEKTKQNVKPVELKTALIPLVHEGRTSMGESLLTNRQIEWIESMPNDYKTENPVLYKKAKEEQIAAATEPVSVVAAREVRGLADYVEAEKTGSDIIERIAESRRLRHEAAVEDLHQDMTVIANDLEPKIADAGSELINKLQENDKEIDKMLARIAQDDDLRDYSLHELNELWNLIGSQSVSRRQWIVELDDTLDGFETQRLQRIQDVLKSYAKNMEKIAFLMPPDVQRLISKEAQVINQTILNNRRAYADLNTRLMKTDVERDKNHHRVWETRVADWKQLNTDVAVDKFTLFMQSEDVKNPCRIGFLLDELKAEQKIFNSKRLDLLQALREMKPPGSTKTAVYEWNKQLATANQQLEQLHIKYLGKLHKEYERVCQDCLDQVDKYREELLEAGVCTEEKVQEVIEEHCLPQVGNQQRIFENTLETIDKSLEQLADKHSEQLRSLFKFSQGAAHLWDVHEIGLAKKERDLQERLEDCRHEHDNQNQDMEANLDIIMDRLRQESSEETLKDRLQKALLMLDKIKTSYEQFHKDQMRIVKDYPDMVKEELRGYDVAVCTFFEVDRLHPTERQQLIEQELNEEAKSRGKKHLKKKTHRSATPAGELTAPPDSRVSSSRSVTGSISQAKMKWKKAFPKRSYPGDSAISQSPVPMAVKEVLSTNAGTTFYVLTVAGEHGISEEDSGKDQDGGGATFLTESDAAEREAVAAYTENVLIPEELFKELRKIMRLEFLNHLEMWSVEAVERANSVVAAKNEELNSELDLRLHLHGPRSKRAELDIHHVRAAELVLHQERVSRHSKGINGALNDVKSRFAEMQHEHNRLAEKFRDEIDALEEVFVNASKSATLVALSHQVSTKVETHMDVIRVSLRQFRQYLDDTLQMLRESNARFIKSFKLFSDGGNFSPEEIDSYKKKLEKLAIKIDSAEGFVMADLEGMEARRLEQALDIANKFEDRFKHHLFDLTFIEKLTRWLTNTQVKIKSEVAESNAQAQALMHHLNVLERRVDACEKPNLDKEQITPTQLLDSLKLVFQAFDDRSKYINCLRHPTFLIDSPAKKSGLPSQSAKVAFTGEEKPPTQQTGQGSTALTTTVTLTTLKAAKPQIEDSAVSLIKNILTSQKMKVKLSGEGDTLADAPHTPGVIRPPGTQSTIQTEEAKARGLGRGGLQVKSLADKDRMKPARKGMGQGVESGNPRRSASGVQRNKHSHLKFDPKYYVFGDRPERETHFLAQIRRILQDALEGLLMTADLYYRQKGLRPPTRPQAIHETFELCADVVVAKLQSYFIQAEEYHNQCLQEFREQLERLEIYNGRVPPLVIREILDKHLKISETSLYKVSEGFKKNMGRWDKERSEHKILLRPTLGHPHNRNQLESLCENEDTRRKDYINGVEANTQNLKDSAKSLGSDFVQELASTSERLLLMFDSLLTVDEVEVGRVDPKRLKTSALIRRKKAGLPLEDNEYVPLIKRGSRQWAGIPTDQLNEEKQRPVKPQLTAAVTTGKTTLAHQALVDARDDVFKDYLTAFDKNLADIDCQQEEQLTAEKRWSESWQRSVKKVKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z547</accession>
    <name>A0A913Z547_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045875.1">
        <property type="nucleotide sequence ID" value="XM_038189947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z547"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189947.1">
        <property type="protein sequence ID" value="XP_038045875.1"/>
        <property type="gene ID" value="LOC119720307"/>
    </dbReference>
    <dbReference type="GeneID" id="119720307"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="752"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="879" mass="100593" checksum="BF146F06FF2AF170" modified="2023-02-22" version="1">MSSADEFGHFRLPLTLNKGNIDMKAAERLFTKTNGKLGRFTESRPEHYASWNLLGMLAFRLGQFEEALQYLDKVLSPNEDPDNLNALANRKYICEKLYRLTEARDCEQKIARLLGEGVTEEGKRRLRKLRARSFFEQAFALTNEIYGFMATDRYRKAFALNQAAIELAGKDVAQSERAAWIFESGLACKSIYGRIKWNKSKKVEVKKFYQGAVNNFITIIQFNEDEDRKIKAWRRLGDLFYHSRDLLPPIQETYREFVDEPDKCFEKALSLSPNNPKVLTRRATHFIKKDQTKALSLLDRAIELGDSEFNLQVRYDRANIYLSQYKQQLKYSQKSRDPMAQRPDDTLLTRAKEDLSFAIKDVSKPWFTELMAEVLYYLATDCYGRLRYGSERLLQQALTYCAKAVEIADGSKRGTVHKVRGMCLCVMGEHQAALSSYKRAVECEIAASYHGGSVDALVLEYKHILPNNHLALREDLPLLADMVYWLQKVAEVSLSTNWDLWQLNKLKQMRDHWKIFVKYCKDNDYEKELEVIESAAIDKRRSSQLQHPISSPHDSDVPPTSEQGQNQSFPSASNVGDAASSFCDASSLSHDIQYKRQTRAKRQLSLPVSVEDGSLPPSVTRRQHSLPASSRYVQPTSRAQGEELSDRTGDNINAEYLRESQGASAAPARPIPDKIDRDIQTLSESLSQVDLDGNEEHHIPPDTIHITYSVNLKTGKTQHVATMPSPEEPPTEVVSKKNVREALERPQNNLGRKYDFFVIYSSSASEWVQHRMLEELEESGFKGCIKDRDFELGKPRNDNYTDSIKDSVCVIIVLTRDFETNNYDVRGMLMALDIDRLVIPVLYEDRVMPLVLKTLEHLDATGAVDWPRLARCIEQQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z696</accession>
    <name>A0A913Z696_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047239.1">
        <property type="nucleotide sequence ID" value="XM_038191311.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047240.1">
        <property type="nucleotide sequence ID" value="XM_038191312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z696"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191311.1">
        <property type="protein sequence ID" value="XP_038047239.1"/>
        <property type="gene ID" value="LOC119721301"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191312.1">
        <property type="protein sequence ID" value="XP_038047240.1"/>
        <property type="gene ID" value="LOC119721301"/>
    </dbReference>
    <dbReference type="GeneID" id="119721301"/>
    <dbReference type="OMA" id="VLVIMQN"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="159" mass="17794" checksum="E49E10C34C61C59D" modified="2023-02-22" version="1">MAFRLRVLMRPLVSASQSQMRASIHVPVSARVVHKAVSIQSRHLSSADSPPYEEFNVQSTEDFNERVINSKIPTVVDFHASWCKPCHALAPRLHEVLSERPGLVQLAKVDVDKHTDLAMDYDVSSIPKVVMVKEGKVAGQFVGLMDKDKIESFIDRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6S4</accession>
    <name>A0A913Z6S4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047513.1">
        <property type="nucleotide sequence ID" value="XM_038191585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6S4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191585.1">
        <property type="protein sequence ID" value="XP_038047513.1"/>
        <property type="gene ID" value="LOC119721509"/>
    </dbReference>
    <dbReference type="GeneID" id="119721509"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="37206" checksum="39530344397FBCCA" modified="2023-02-22" version="1">MEEILWLRIFKTIVGIVGILGNGLVCLVIGNVSSMQTRTNAFIFHQAAVDLLGSLMILLQSGVPLPDQMPDGVLGLIVCNVWYSNFSLFLLFVISTLNLLSLTLERYFAIVHPFRYQAAFAKRPKLKVGVVIAVCWILGTVIKSYSLTIFKVQDGKCVSNAANRSKVIGSLTTVLQYIVPVAVMLFAYIRISVELKRGAARVGPAPSVISSAAGASNGDGNAQPAGLMESLLRARRNTFKMLWIVFITFLVCWTPNQTIFLMFNLGWKLNYDGWYYLLSVAMVAANCCVNPVIYAFKYRQFRKGLRELFCSRRINREEAVNSATSCRHSLHGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA94</accession>
    <name>A0A913ZA94_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048549.1">
        <property type="nucleotide sequence ID" value="XM_038192621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192621.1">
        <property type="protein sequence ID" value="XP_038048549.1"/>
        <property type="gene ID" value="LOC119722481"/>
    </dbReference>
    <dbReference type="GeneID" id="119722481"/>
    <dbReference type="OMA" id="VENEQFF"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="181" mass="20014" checksum="AF762F8FB3B6A394" modified="2023-02-22" version="1">MDKINDALKDMDVTTKIRVYKKFKALDTDASGNLDLAEFTKGFESVGLSDAEMKAAFDSLDKDKNRTLKKSEFMDILLPSMSDARKAKLKEVFQSADKTGDGVISTADLSKAFAANDPGVKAGSKTLEDVQNEFLNTFEPEGAGKDGKVTFEEFEKYYTPVSQRFASDDEFINMVKASWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEN9</accession>
    <name>A0A913ZEN9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038049519.1">
        <property type="nucleotide sequence ID" value="XM_038193591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049520.1">
        <property type="nucleotide sequence ID" value="XM_038193592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049521.1">
        <property type="nucleotide sequence ID" value="XM_038193593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193591.1">
        <property type="protein sequence ID" value="XP_038049519.1"/>
        <property type="gene ID" value="LOC119723084"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193592.1">
        <property type="protein sequence ID" value="XP_038049520.1"/>
        <property type="gene ID" value="LOC119723084"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193593.1">
        <property type="protein sequence ID" value="XP_038049521.1"/>
        <property type="gene ID" value="LOC119723084"/>
    </dbReference>
    <dbReference type="GeneID" id="119723084"/>
    <dbReference type="CTD" id="3052"/>
    <dbReference type="OMA" id="NEESWKH"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34564" checksum="81F3D55A7DEEB981" modified="2023-02-22" version="1">MGGASSTTVQASTTLATTIIPSPTSTEDNPATTRVTSSTSPPKECPMHSSRKDEQLDIRKMAKTGQIPSGCPMHKKEGAEVMTTGAAVSECPMTGASSPALMTDSRTDDIDPLNMMPPPNQRPAPDQPFSLSTDRQVSNIPKGNKDGEHWVYPSEQMFWNAMLRKGWRWQPDDISQGDMHNIIKIHNANNEQAWQEVLKWEALHAKECGDPKLQSFGGKYTALSPRAKYRMWLGYERPFDRHDWIVDRCGKKVRYIIDYYDSGVVDTDTYKFALLDVRPALDSPGAVWDRMKVAYWRWMYDAKDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFZ8</accession>
    <name>A0A913ZFZ8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050713.1">
        <property type="nucleotide sequence ID" value="XM_038194785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194785.1">
        <property type="protein sequence ID" value="XP_038050713.1"/>
        <property type="gene ID" value="LOC119723889"/>
    </dbReference>
    <dbReference type="GeneID" id="119723889"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="125" mass="13490" checksum="C8851CE29A853FFB" modified="2023-02-22" version="1">MAEQEQLMPTQDAERQGQVADGDCAETQEQALALRRPDNQDQTTDMIPVAAVNQLQQSVQQISGSGHVPIFNPKDCTINIYQSKDDAHASHHSGHPSVDISENPPSTSQQPTTSHVASGAQGNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG23</accession>
    <name>A0A913ZG23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAM69 protein-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049996.1">
        <property type="nucleotide sequence ID" value="XM_038194068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194068.1">
        <property type="protein sequence ID" value="XP_038049996.1"/>
        <property type="gene ID" value="LOC119723428"/>
    </dbReference>
    <dbReference type="GeneID" id="119723428"/>
    <dbReference type="CTD" id="205428"/>
    <dbReference type="OMA" id="LWAACYI"/>
    <dbReference type="OrthoDB" id="10035316at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073:SF7">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="48240" checksum="D265C2ABDCEBBEC3" modified="2023-02-22" version="1">MAYCRRLCTRLCLACSSQKCLRFLLILLVVIGASIYYNLFFFLTTNYLEDRDFVGVDKCPACYGTSMCHEFNHGHLSLSSYSRMRFLDIVNVKNVYFGWHNEKNIDVILKRLGHDTELASFDANLCKNAGAGQDCDVAKSIFQTKFSRVLETTSLEVAHVEGLSDVVRCPSERLLERILMMYRDHVPGQSLSKDHKLMLMTMLSVNPEPIIYTIFPHSEGWPFPQYYGACGRLIVEEYVGKTLGSYFHSDWSTRLDLAYQVMKIAEQLTNNDLEYALYMTDVSFDNFAVNKDGRVLVIDAENIIVVDKRKIKTDAKPSWNERHQSFHDECKSHPGCLSFSSELLCKRHSSDHNYYATCHGLLAKNSEWAGTKGGLLHDPPADLPEREQLNTLIAECEKPSQRNGRYDAMQQLLQLLSELTDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH08</accession>
    <name>A0A913ZH08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050304.1">
        <property type="nucleotide sequence ID" value="XM_038194376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050305.1">
        <property type="nucleotide sequence ID" value="XM_038194377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194376.1">
        <property type="protein sequence ID" value="XP_038050304.1"/>
        <property type="gene ID" value="LOC119723632"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194377.1">
        <property type="protein sequence ID" value="XP_038050305.1"/>
        <property type="gene ID" value="LOC119723632"/>
    </dbReference>
    <dbReference type="GeneID" id="119723632"/>
    <dbReference type="CTD" id="55135"/>
    <dbReference type="OMA" id="IRTWILP"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="544" mass="60357" checksum="E16FEC8546753756" modified="2023-02-22" version="1">MATTDASGARNESGVKMMTVDETSETPSILGTTTHLEEIHDSSIEACDTSEQINVETVAKDVPEVKGHRDDESNVEQEETVGCIKEQISPAQNQGVVEIPDHKNGSDDHADPSQTLEMESECVAMETRLEDDEMKQNENETGKTTTDEFPEQTVATDEAYSSYSPDYRQVPYQLTGAWQDFQHTPENFLKGCKWSPDGLCVLTNSDDSRLRLFNLPQEVYSSHWQDEPIPEMTSVLNIHEGELIYDYAWFPPMRSDQPETCCFASTCRDHPIHLWDAFTGELRCTFKPHNHLDELATAHSLAFSADGSKLYCGFNKMIRVFDTERPGNTCQDRPTKDKKSGQSGIISCFAVNSEGLYAAGSYSKSIGLYTEPSGSMVCMVQGQVGGVTHLMFSPDGNRLYSGGRKDPEIVCWDMRNPGRVLFSLIRDVSTNQRMYFDLDSTGQYLVSGNQDGTVSVWDTTQPPVIQGSNGESIIDPILRFKAHSDAVNGVSLNPTMPIMATASGQRKFPVPMATGDSDEEEEAAMVEELGEENSLRLWYLMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHS1</accession>
    <name>A0A913ZHS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050944.1">
        <property type="nucleotide sequence ID" value="XM_038195016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195016.1">
        <property type="protein sequence ID" value="XP_038050944.1"/>
        <property type="gene ID" value="LOC119724106"/>
    </dbReference>
    <dbReference type="GeneID" id="119724106"/>
    <dbReference type="OrthoDB" id="5950607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037332342" description="ADF-H domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="4">
        <location>
            <begin position="62"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="23498" checksum="7AFA950F7E5B9E64" modified="2023-02-22" version="1">MFGLRTALLLLVAINVLVNGYQDDGYLDGELEVLLKRLLEGLEEEERGYELKNLFERESMSGMEVDEEVSTIYNDMKLRKTLKWITFKLENKKKIIKDQSAEPNDNYGDKTQFDEMKAKLTSEPRYILYDFKFDSKEGRKINKIAFIFWCDDDNAKIGDKMIYASSKDTIKKAFTGLGLEFQANTMAQLDYETFRAEVEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIP4</accession>
    <name>A0A913ZIP4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048701.1">
        <property type="nucleotide sequence ID" value="XM_038192773.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049661.1">
        <property type="nucleotide sequence ID" value="XM_038193733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050915.1">
        <property type="nucleotide sequence ID" value="XM_038194987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192773.1">
        <property type="protein sequence ID" value="XP_038048701.1"/>
        <property type="gene ID" value="LOC119722591"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193733.1">
        <property type="protein sequence ID" value="XP_038049661.1"/>
        <property type="gene ID" value="LOC119723171"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194987.1">
        <property type="protein sequence ID" value="XP_038050915.1"/>
        <property type="gene ID" value="LOC119724068"/>
    </dbReference>
    <dbReference type="GeneID" id="119722591"/>
    <dbReference type="GeneID" id="119723171"/>
    <dbReference type="GeneID" id="119724068"/>
    <dbReference type="OrthoDB" id="10119857at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275626" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="18969" checksum="7AAF5B3118C03735" modified="2023-02-22" version="1">MLQILLACLMLVVSRVESNWNAEESDSSKAKMGFSRINMTCNDAEDVCQHCVIIPLFGQEFLTVVEYTKDPYQLEVSVQEGRQSRDWTFSQDDLAGKYRWCESAYSEASWDYDHSWRYTICYENIFDDISVPEDCAKPLAVVTHESHYYDDEVRGQQMLFCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ06</accession>
    <name>A0A913ZJ06_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051030.1">
        <property type="nucleotide sequence ID" value="XM_038195102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051031.1">
        <property type="nucleotide sequence ID" value="XM_038195103.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195102.1">
        <property type="protein sequence ID" value="XP_038051030.1"/>
        <property type="gene ID" value="LOC119724169"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195103.1">
        <property type="protein sequence ID" value="XP_038051031.1"/>
        <property type="gene ID" value="LOC119724169"/>
    </dbReference>
    <dbReference type="GeneID" id="119724169"/>
    <dbReference type="OMA" id="YSHGRAN"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="529"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="638"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="734"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="827"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1304"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1453" mass="158147" checksum="4634BD03A81D1F9A" modified="2023-02-22" version="1">MSASEPVIGTYPTMTNHLSMHDLPQTQLSSETSSTSSELESALGNAVKTPPGPAAENGPDGYPSDGSSSVENQGSGTGNNNPVTVPVPYLNGPLQIPQTAPAGYTEYVDGHADGNGLDYTAQGSEYDAQQQTVADYSPEYAPAEPMYPSGQDYTTNAVGVPAPVQDYPGMGVGVGDEVPPQGQVHDTGQNAGQVNKKYVFYLQIKQGEAFPIGNGDQVQYIHGPTLIQFVSDSPVPPPLHTVQTGHGPVSMPTVASVPVVSAPMAVPTGMALQQPVQDAVVNDMQQQQQQQQQQQQQGMYTPCPPALSPQQPIYPALYSPNGGGGRAGGMGGVYPHLMGYPNPGMHHHVQPHVASSVPAHSAVPPNSGVPVPPHHHVNIHRYSHVPPHGQHNSQQQQQQQQQQQCNMPDHSHIQDPQRPSMRSRSRDDRTDKQREKLQKKLRDRQHQDKAPSYIPSPQTSPRGGGGGGGGGLYGGGGGGGGSYNPSVLKMENGANSRQGNGRKKRLSGPRIDENEEDPHSKKLRDLLSNIQPPDVYNRLARSVSVRWSLPQVHSGNGDCCPDDDIDLSSARFELVLSERNRSGSSKTFYCHGTENEYQVPDLKPATEYQLSVCAILDNVKGALSQPAIFESRGCPPDAPLIPRLSGRTKNMLSLRWNPPLPNGAKIHSYLLQCDKGTGSGSFVDVYEGPDKTFKVTKLQPSTLYRFRLQAINDYGASDFSPEVSYYSSGSAPNQPEPATLREATAHSLHLEWEKSTGEIHGYILEMEDEMKRYGFQIVYRGEETNHQCKNLARNSEFKFRLCAFNEEGNSRLSGVVAFRTLPDTPRAPCKLSLKGKVHSTGFKVSWDPPKDAGGSDVTSYCLEMSSGTNEPFVSVYEGLEREFNQDSLEPGHTYRLRVQCSSRGGDSPFSDICSVTTLPVCPGQCLPPRLHGKPRATSVNLRWSSPEYHGGTTLQEYALEMSAAADDTPKEVHRAGTSITECTVNALLPGRPYNFRLRAFNRIGGGPLSEPLHVMTAAGPPDSPTDLAVSSRSTSSVAYVSWCKPCCNGAEVHEYRLERASENGSFSTVYNGFAPSCELKFLQPATFYYLRVQAINSAGPGPFSDVATYESPPSSPEAVASLRLLSSTSESLLIRWTEPNCCGSEILSYNIDIGEKPVISVQGNVTEHCLEMLQPNTKYRIRIQAVNSIGVGPYSASLKVTTKALPPDPPRLECVLYSHQSLKLKWGDSVKSPVDVRIQNYTLEMEDRKGRYCVVYCGANVSHKVSKLSEQTSYRFRIFASNDAGDGPYSESYTFTTTKAPPPCLKTPKVSLISEDCCVVEWQALGNIQNDVVIYQCQCQRVRDSEIKLVYRGPGSSVIVPDLSPGTEYRVRTCAVRLPEDGGPELVGTYSPWESFQTASLVPVAPVIAEDPQKEEPLSAEPKALEDQKLVAIFLAVFFFIAVIFAWIVAFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ33</accession>
    <name>A0A913ZJ33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051071.1">
        <property type="nucleotide sequence ID" value="XM_038195143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195143.1">
        <property type="protein sequence ID" value="XP_038051071.1"/>
        <property type="gene ID" value="LOC119724198"/>
    </dbReference>
    <dbReference type="GeneID" id="119724198"/>
    <dbReference type="OMA" id="QRMQVEM"/>
    <dbReference type="OrthoDB" id="5962185at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF2">
        <property type="entry name" value="FI05246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="235" mass="26379" checksum="81DD7BB588B71F2E" modified="2023-02-22" version="1">MALSMFKRKPKSSVAAAAAASPKEKTFTIQYLGSLRTFKGKGSDCLDEPLQEIWVKSNKGTRSAKAQLTIAADGVNLERMDIKDLPTSVQFFHLNRISHCGLHPKYPRVVTWIHRNELQRMQVEMRAHAVICNRSDKARMIADLLNERLRSAFADFKQEMKVRDKISIRRSSEGTLDVAGLQKLQNHRSTFMPPVAKRGSVPALGIILEKGKLVGVAETIEADEEEEEDEDGDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ86</accession>
    <name>A0A913ZJ86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051121.1">
        <property type="nucleotide sequence ID" value="XM_038195193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195193.1">
        <property type="protein sequence ID" value="XP_038051121.1"/>
        <property type="gene ID" value="LOC119724233"/>
    </dbReference>
    <dbReference type="GeneID" id="119724233"/>
    <dbReference type="CTD" id="54840"/>
    <dbReference type="OMA" id="CLKTKYH"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000004">
        <property type="entry name" value="aprataxin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="11">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="9">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="203" mass="22935" checksum="127641021AD1B0A2" modified="2023-02-22" version="1">MATAKPGQKRPLGSSGGGPPAKKGFWSLGLLDSMKDPNLQVEKDDKVVVIKDKYPKARYHYLVLPKENISKLKALQPDHLELLKHMHEVGERIIKEAIGEEGLSYRLGYHAVPSMSHLHLHAISQDFDSPSLKTKKHWNSFTSAYFVDSKEVMDQLEKEGKVDTSAKNPEAQLKLPLRCHVCKKELTNMPKLKEHIVTHIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJY4</accession>
    <name>A0A913ZJY4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052132.1">
        <property type="nucleotide sequence ID" value="XM_038196204.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196204.1">
        <property type="protein sequence ID" value="XP_038052132.1"/>
        <property type="gene ID" value="LOC119724900"/>
    </dbReference>
    <dbReference type="GeneID" id="119724900"/>
    <dbReference type="OMA" id="CGITACF"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000011">
        <property type="entry name" value="cytosolic carboxypeptidase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF45">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE NNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="355"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="912"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1430"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1531"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1470"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1535"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1604" mass="179360" checksum="B588B31C4A2EFB6D" modified="2023-02-22" version="1">MRQSSRPQRRAFTDEPKMYGGGKQDYVFDFDLDPYQSFMRNHLKHYGYYTGRNESYRSSAHTFDEWDCTHGYAISDQGSDTEYENQALKDDKANVQEEKRTTQLTFKYQAGKMVPRLREPRHLYAQSKDGGSQQAPRWPADVEVLSNRVCHVPYVPKEREAFYQPTGYEKMPQPSAEGEGRVVYFSPPTKEAYFLRSRVGGSRSGCPLRAVKIKTPEDTTLVIEARFESGNLMKATQVSENEYELQLRYDLYTNKHTQWFYFRIQNMRRGFKYRFTITNFMKPGSLYNNGMRPLLYSEIDAQKRNIGWHRAGEDIKYYKNYLKRSDGKGDRNFYSLTWTCVFPHDNDVCYFAHCYPYTYSDLQDYLLNVSNDPVRSKFCKQRILCRSLAGNIVHILTITSPAKNPEDAKMKKAVVLTARVHPGETNASWMMKGFLDFLTGSSGDAKLLRDTFVFKIIPMLNPDGVIVGNYRCSLAGRDLNRNYKSVLKDSFPSVAHTKLMIKKLMEEREVAIYCDLHGHSRKQNVFIYGCENKDNPKRRLRERIFPVIMGRNAADKFSYDICKFKVQKSKEGTGRVVVWQMGIMNSYTMEATFCGSTLDDKKTGHFRTADYEAMGHHFCDTILDYFDPNESKCEQILSDLEEKLRQQILRHLERTGSPLPANGIIDLSEDYSSALESSTTGSDSSVDDGLPVHLLALAPKLTKKKKLKTRKERDKKRNSLEKSKEKEEEKKPPTPKKDNQKMKYRHTDRSTLHSAGKTRPVVNKTGDGMPVFAQERCEEKNIKKTEYLEALTNAYLMSGVLKPSQDVPSFRYSAGNASLSASGVPLAHMDGLCPHHEKALAQQYVANQLAGLSFTDNWNRCADEPPTTVEAIPQPTLSPFQHRNFNNHMVTMNALQQQQRPLNEYIRQAAHHIKTRPQTGKKARAGSASPIKTHPSPFDEQSEGSTGQQSNSSKRGASSRSGRSPSATSFAVYDGHSYGSLLGHDRPSSKHSAQAGSHYSSFVTKKKLNHEDDKPGSSGSVIDPTHPPVASSSASSLLSETARGSSANSAQVNSESHRSNQGTATPNAMETQNLTRGSKGESEVRRYRVPTPVSSSKSPHTVSKIHRCSTEATPITDTSAFTLQQRNTKSSHHFQKAQNFYSGSVVTAKSDQGKRNGTSPSRNDKKGPEGGNGGSSGIRSKQTGSPAENLTGYRMSVASLKKAGLVGQNYANTNNNGEQTSADGNDNAEDKSGRKVEGMEEVNDVAQQRQVLVSPVGAENGDTISLHYKNEIGGKSSDTETDSEAWKEIRKPKTFRDNLNGSNATENEAHHRTRHQSHEQQHRQRFENRVKSAGQRSVMSSRSEPSNPDGRLLESNLRNSVQTSGIVGRPVAGRPVTRPLSCSSSVRYTPTSSVKNVNGARPVVDGMQKYKPVTGTEEAIYATMSVKPFPNRPQTPVGRSVVTGNQAMKGQQPIRRNNLKQGRSRSPRSQSRDRYDDDLYADRVISPQSTSKFVHVQQLALQMRGFGIAPSSDQGGPCDGGSSYHIVMEGAESAGPRDEKSGRRTSEPPRSGRRSAKGVRSPMMHESKFSPEDATAEPSVVVEFQGGFQGNQKSAAMMRYARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKZ8</accession>
    <name>A0A913ZKZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051721.1">
        <property type="nucleotide sequence ID" value="XM_038195793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051722.1">
        <property type="nucleotide sequence ID" value="XM_038195794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195793.1">
        <property type="protein sequence ID" value="XP_038051721.1"/>
        <property type="gene ID" value="LOC119724647"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195794.1">
        <property type="protein sequence ID" value="XP_038051722.1"/>
        <property type="gene ID" value="LOC119724647"/>
    </dbReference>
    <dbReference type="GeneID" id="119724647"/>
    <dbReference type="OMA" id="SYNYVER"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF501">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="569" mass="64255" checksum="6E9ABFD36E9A706C" modified="2023-02-22" version="1">MHLKMIQSRTYTITLHTHSAFTVMNELRQRQELCDVVLRLEDQAFRAHKVVLAGCSPYLRAMFTNGMKETAKNHVEIHGVDPVAMEIILTFMYTGFIEINVENVQIVLAGASMLSMSSLRNVCCTFLQSQLDASNCLGIHSFADMYSCTDLENTSRRFIYQHFREVIRSEEFFVLAEQDVVALLKSDQLQVDGEEEVYEAAVSWLSYDLQNRSRCCCTVLQHIRLALLDKDYLLQRVHQSELINRCSKCRDRLANALRIRNDNQALALIGSRSQPQSIYVVGGRNSVDCQLSSCERYDVSRDRWVPQESMSISRTAVGAATVNGLLYAVGGECAFSGSRDDQTMYLGQVECYDPLLKRWNPRSNLNVPRSFMALASLGGHLYALGGENASSSYNVVERYSPITDDWNFMPNMKQKRSGCGVAVCDGKVYVAGGYDKSYHTDRASVECFDPETEEWTFVAEMEKARSGLALVAMDHYIYAFGGRLRHTDQYFNIAERYNTQTHQWSSIRSLQTPRAWPAVAIFDNKIYVMGGFDGTNRLRGVEIYDPYTDTWTVASNMNVARAGCGAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLK7</accession>
    <name>A0A913ZLK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052662.1">
        <property type="nucleotide sequence ID" value="XM_038196734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196734.1">
        <property type="protein sequence ID" value="XP_038052662.1"/>
        <property type="gene ID" value="LOC119725338"/>
    </dbReference>
    <dbReference type="GeneID" id="119725338"/>
    <dbReference type="CTD" id="84336"/>
    <dbReference type="OMA" id="HVEFWNQ"/>
    <dbReference type="OrthoDB" id="6082754at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029371">
        <property type="entry name" value="TMEM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15111">
        <property type="entry name" value="TMEM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28468" checksum="F75829A8688C1781" modified="2023-02-22" version="1">MAAPSGRGNISLGLKKLGAFILTRLPFASAVVFALLCHERESNERPLGYPHIVIYIHVALLMLEGSMMSFATQRSLFALMCAVQIAVMMLVTHTSPSLRYKPWLMIRMLSRDLGVIGSYLILASRTHEELSRRYRLAKLYPLGRSLLASYFIVLAFQLNREAVEQDAFVHHIPGGIVAVSAFCGACMVCSLMFLSQYKVKPAVRVLIVLGLLFTVMVDLDFKYWKRRHVEYWNQVTILVNDLGMVAMLLLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNS8</accession>
    <name>A0A913ZNS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052765.1">
        <property type="nucleotide sequence ID" value="XM_038196837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196837.1">
        <property type="protein sequence ID" value="XP_038052765.1"/>
        <property type="gene ID" value="LOC119725432"/>
    </dbReference>
    <dbReference type="GeneID" id="119725432"/>
    <dbReference type="OMA" id="SATWTIW"/>
    <dbReference type="OrthoDB" id="5987060at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587300" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53869" checksum="A3CA2224E2513B9D" modified="2023-02-22" version="1">MAIWVMLAVVLIADLVDFAQAACLPCNFQWTENNGTCYRYFTNSLSYTEAKAFCQRLNYHGRSGSLATVTSPDDILFISKFADDMFKYATGFDVPSFIWLDTHALNTTVSDLEPILDLPLGQMSNVTPCENNQVVDNEAYQVVGTAQMVPGPELVEQPCAVHASLGSYLDLGDFAGSCVSDPGLCESETVTWSIWLKIDTPVSVNKNDWYYLSSGGQTSQSRGIAFMYKKDSQKFWIIAKSGHFLFNRKYNKSKIPLDEWFHLAFTADLSGTRGTDLKVFVNGDMVNADVMKNLTATTQSDGCTHLYFGMSNTCARTYSVDTYGGSAAYSNLVVFDGLLSSQQIANLYKCGYIDWRPRIINFTMTNYGTTDGEIRFNCTADGDVITWSLLHENNPNNVSWENLATIAGAGYTIQAVNASRCVIHSTLVIYRNHGLPLEGALVACSAHSYHLRDKASMFIYQGKQVNIGTSHHGSIGKCDSVFLLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNZ2</accession>
    <name>A0A913ZNZ2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052761.1">
        <property type="nucleotide sequence ID" value="XM_038196833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNZ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196833.1">
        <property type="protein sequence ID" value="XP_038052761.1"/>
        <property type="gene ID" value="LOC119725427"/>
    </dbReference>
    <dbReference type="GeneID" id="119725427"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="190"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="363"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="537"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1230" mass="133526" checksum="AB74C69E62D42463" modified="2023-02-22" version="1">MARNGIHGDRLNDTIKATSDLNNFITEKQGKAITNNLLRMTSRELRGTIVKEFLDGPVDIFDIASANCDFEGQDTCDWTNAGLEVYPVSPSTGLDMFSAPKIDHTTLGDLNVYMYPVTDGDDLSLKQPVYQLTGPQTGLRVWLQVNIDYIAQENFEIALEFVEGNTGRYATAVDDLTVVPSHCPVPDLSFNCTFEEGSCGWIQSEFDDFNWLLEQGRTPSTDLGPVIDHTRGDGNGRYYFFQATGLFTSQYAVLLSPLVNSSDSQDGSLCFSFWYNMFGINIEELEVVVTTNLTEPLGTFIYRIYKEQTSQDVWLQAMVDIVNQTEDFHVGLVGRVGGISSSEIGIDDVSIIPGLCPQGNQAFNCTFEDGYCGWTQREGDGDNWIMDRASTKITSTGPDFDHTLGDNTGRYMYFSPSQFMYTPIFESPVVEVNGENGLDLCFSFWYNMNGRYIGTLEVYSYNATGSSSNTSGSVKVFSASGPQTGRRGWLHGLVDIRDVNSNIRFYFRGVPLGTRNGDIAFDDVSLQRGLCEKDTNFNCTFEEGSLCGWVRSDEDDKHWQLQRGATDTANTGPDFDHTTGTIEGSYLYLEATVATTAILLSPVVTPPVTDALKFVFWYNMYGDATGTLNVLKVPEIGNLSSSQMVYSMAGQQTADSTWLKAEVFLLDLTSSFQIVLQANRGVGISGRSDIAIDDLEITSNIGEIPIVTTDVQTTTAVDELSTSEQTTGVATSSNDETSTSEAPIQLSTTDHGTEIATTDETYVTDATPELTTVEGITIVLPTDASIDQTSTAADGGDGGVATTGSMIDQTSVTDATLELTTVERVTGVLSTDASIDQTSIAADRGDGGVATTGAMIDQTSVTDATPELTTVERVTGVLPTDASIDQTSTAADGGDGEIATTGAMIDQTSTSDGGNGGIATTSTADGGESSTVTEGTMEFSCQLRILELNGALAVFNDRLTDSNSQEFRDVANIIRPAVIAALRRSPRTSNVVDYEVISVRDGSLLVNGVARFPLNSVIESAAIREVLHSEAMSNNGLIDNSLTIDLSGTVVTAPTEVCPAYVCQNGGVCTQSGSFPDYVYTCGCSDGYTGTYCEETVPGNGGIIAIATTVGALLLCSIVVMICVCAIMANRSEGPLQRRRRFAQQEEDHARERYRYGVRNWTRPAIMPRTVLEVDDGSMDDARAFYRTYDYSTNYRREDGFSRSYSPYMIPGPALMRKMDQERMTDDYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPT0</accession>
    <name>A0A913ZPT0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053139.1">
        <property type="nucleotide sequence ID" value="XM_038197211.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053140.1">
        <property type="nucleotide sequence ID" value="XM_038197212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPT0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197211.1">
        <property type="protein sequence ID" value="XP_038053139.1"/>
        <property type="gene ID" value="LOC119725688"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197212.1">
        <property type="protein sequence ID" value="XP_038053140.1"/>
        <property type="gene ID" value="LOC119725688"/>
    </dbReference>
    <dbReference type="GeneID" id="119725688"/>
    <dbReference type="CTD" id="3516"/>
    <dbReference type="OMA" id="QRQDMPH"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01176">
        <property type="entry name" value="IPT_RBP-Jkappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000001">
        <property type="entry name" value="Recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000003">
        <property type="entry name" value="recombining binding protein suppressor of hairless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000074">
        <property type="entry name" value="Recombining binding protein suppressor of hairless, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
            <begin position="216"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="13">
        <location>
            <begin position="348"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="631" mass="69450" checksum="BE0903241C5B9AB2" modified="2023-02-22" version="1">MTQYMLQRFLAQETEAIHNNAYDAALSFSQATDLQITNGELVPVQGQPGEDVSGRGGAPPMLNGHDHRRMSASLKRSHDLMAGGGNGGGASAVKGSVVGPGLGYATVMLTEESREPKVKTQNTHVTSHGLPTTQGPADKLSSSDLVTMVTSASPLSISTMATTVHTPPSPAPSPSPSAVANTAAHPDESIIPIARNEKKLTKEAMGQYLRDRCHQTVVIQHAKVAQKSYGTEKRFFCPPPCIYLLDPGWRRKREQMQHDGETEAGSQVCAFMGIGNSDQDMQQLNLEGKDYCAAKTLYISDSDKRKHFLLSVKMFYGSGEDIGVFNSKRIKVISKPSKKKQSLKNADLCIHSGSTVALFNRLRSQTVSTRYLHVENNNFHASSQQWGAFTIHLLDDEESESEEFTVRDGYIHYGSTVKLVDIVTGMALPRLIIRKVDKQTSLLDADDPVSQLHKCAFYMKDTERMYLCLSQERIIQFQATPCPKETDKEIINDGASWTIISTDKAEYSFYEGMGPVKAPVTPVPVVIDLQLNGGGDVAMLELTGENFTPNLKVWFGDVEAETMYRCAEYMLCVVPDISAFRGEWRWVRRPTQVPVTLVRNDGIIYPTGLTFTYTPEPGPRPINGALDGILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTY7</accession>
    <name>A0A913ZTY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055057.1">
        <property type="nucleotide sequence ID" value="XM_038199129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199129.1">
        <property type="protein sequence ID" value="XP_038055057.1"/>
        <property type="gene ID" value="LOC119727272"/>
    </dbReference>
    <dbReference type="GeneID" id="119727272"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="24719" checksum="CD674F580EEF6C9C" modified="2023-02-22" version="1">MEIHQVNSFGSNVAVNIWWNHQAYVVPSSESCGRPNPGLDISLVDVRFPYHDQPDTGIGFLRDLHPEVDFVRDPSASLRAFMDEEETESLTEQQFLEFMDMMLSGPEGEIWTEEALHVAHQMFQMLDTDGNGEITSHDMDKFPLKINKFDSFFINLGQKMMILSDIADGQISKQVQEILNKFEEDKVRDVGDTPSHEHGSKYRWTSGHTPMRKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU39</accession>
    <name>A0A913ZU39_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054591.1">
        <property type="nucleotide sequence ID" value="XM_038198663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU39"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198663.1">
        <property type="protein sequence ID" value="XP_038054591.1"/>
        <property type="gene ID" value="LOC119726801"/>
    </dbReference>
    <dbReference type="GeneID" id="119726801"/>
    <dbReference type="OMA" id="GMTCIFT"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="145"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="349" mass="37186" checksum="3315B5D25B015AEA" modified="2023-02-22" version="1">MHFKSQFKTAYAVAYAGGGVGGIAIPPLLQLLLEAYGWRGAMLVISAIAANLIGLSALCRPPRSKRCLHAENTLEVQMQSSFDEGKPDGSNVRNEDLSVSDADHLEVGNIAGGRLANSTTDDITEIVSLETGSKSTRLTHHLRHFASAVGSDLFVKSYRFTLVCLLKIELGFASYSCSQFIIPRAEGTGVSPSSAALLLSVFGIGLLLGRLGNGLLIISRLSVETVSGLCLSTAGVSLLLMNVDSYVSMAVASFIQGLTSGAIYTIFIVLTRHYVGLERFSVALGMTCIFTGIGALCGPLISGLLYDVTSSYKTIFYLLAGVYFAGALLTLFFPLLKRLEPGVENTKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU87</accession>
    <name>A0A913ZU87_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054794.1">
        <property type="nucleotide sequence ID" value="XM_038198866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054795.1">
        <property type="nucleotide sequence ID" value="XM_038198867.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054796.1">
        <property type="nucleotide sequence ID" value="XM_038198868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198866.1">
        <property type="protein sequence ID" value="XP_038054794.1"/>
        <property type="gene ID" value="LOC119727001"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198867.1">
        <property type="protein sequence ID" value="XP_038054795.1"/>
        <property type="gene ID" value="LOC119727001"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198868.1">
        <property type="protein sequence ID" value="XP_038054796.1"/>
        <property type="gene ID" value="LOC119727001"/>
    </dbReference>
    <dbReference type="GeneID" id="119727001"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="434" mass="48413" checksum="913554E48D4979CB" modified="2023-02-22" version="1">MGNYIHLNKCVQFGEYSLKYLVITNSCKQGVLTTITRMSTCAFIRDKKKKWVSYHLLDVKKMSYKSDQIKSLCHIPESRKKESSNINEHIRSGLDSKRKTCSNERLDESRTLETAEHVSDDNDFGCSGDLLQSSDISPVVGNGNRVTKHAGKRNQSRRFEDIVPPPGTDMLYGISPCLLALEVNRRQVNNVYVTSSFKKSARPAVQKIMQRVQDKHLGNFIHEVHRKDLDKLSKGRPHQGICLETSRIHFKPLPEDATVDEQELQEPLVYLAMDQILDPMNMGAIIRSAYYLGVDRIIASKHSCCSLTPVVSKASSGAMEIMPVYSTSSLLTFIMKQRDIGWEIVGSTCAFNNWTHTLNVSSAASFKLSKPTVVVIGGEGSGLPDSIQNACCQLLTIPAGRELHTSIDSLNVSVATGILLQSILQQKQLPHRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVK6</accession>
    <name>A0A913ZVK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBCC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055561.1">
        <property type="nucleotide sequence ID" value="XM_038199633.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055569.1">
        <property type="nucleotide sequence ID" value="XM_038199641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055577.1">
        <property type="nucleotide sequence ID" value="XM_038199649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199633.1">
        <property type="protein sequence ID" value="XP_038055561.1"/>
        <property type="gene ID" value="LOC119727645"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199641.1">
        <property type="protein sequence ID" value="XP_038055569.1"/>
        <property type="gene ID" value="LOC119727645"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199649.1">
        <property type="protein sequence ID" value="XP_038055577.1"/>
        <property type="gene ID" value="LOC119727645"/>
    </dbReference>
    <dbReference type="GeneID" id="119727645"/>
    <dbReference type="CTD" id="55171"/>
    <dbReference type="OMA" id="VPNAWDQ"/>
    <dbReference type="OrthoDB" id="427777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="300"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="551" mass="61221" checksum="83D984FF33DC1E0D" modified="2023-02-22" version="1">MAVNASLWLKFDPFHIGALQVSPHPKLSVHYLRKIAVYAKTKGKAGFPNLSYPVWKHIALNKLNICEDLAWMFFEGYDLLCECPAETRLKLAEKLQGCKTPQEKEFIKNQASVDTLEFLIYLFIQQVHKISLRSSLVSGEEWPTRPRSPDVDSRGGTINSKSLDENTHMTFLQTHLSDMLSLLVEADPYAGSATDVLMSLQSVQAMSFILEGSADGNKTVKPIHDLAKTQGLQLRSGYSKITLAFTCRTFESWIRTSLVANPYGVAACISAGHRLSWPTAGADGDAAKRGRMATNAQKAPSKSKLVILSQICKQTLAKSSATLVNARVKVHRCHHAFIYLLSPLKFVSIEKCRHSTIVLGAVETTVHLSGCEDTKVITATRRCSVSGSTLCTLHLLTPTRPLLLGGNDAITLAPYHTHYPTMQQDMAQVGVGEHPNVWDQPLCIGPDHQEDNPVYELMKPKDFFTFVIPFEMQGETTEIPGGLPARFERALTERNRQIQSWQQMVKEAGLSSAKRKQFQALVESRFQAWLEESGHKRELDSLVPAHASLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWN6</accession>
    <name>A0A913ZWN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056063.1">
        <property type="nucleotide sequence ID" value="XM_038200135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200135.1">
        <property type="protein sequence ID" value="XP_038056063.1"/>
        <property type="gene ID" value="LOC119728056"/>
    </dbReference>
    <dbReference type="GeneID" id="119728056"/>
    <dbReference type="OMA" id="IKNSHAF"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF4">
        <property type="entry name" value="DYNAMIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="429" mass="48519" checksum="8CF419C0570032EE" modified="2023-02-22" version="1">MIRLLSLSHCCFLFIVSAGLISIADKLGLRLLAPRKKINILLIGNHSAGKSSFINWYIEEHVQKTGVAIETQGFTFVTSGRKRESLTGNATLHLYPHFKELAQLEGVVEYLTTEISTSKQKRFSLVTFVDTPGLVDGDMKYPFDVDKAIIWLGNLADLIFVFFDPIGQALCKRTLNLVERLNETHADRMKFYLSKADEAGHESDRQRVLMQIVQELCKRPGLNRTGFDMPTIYVPQSSSKSRCVNQIETVCVHIEKTINQTIQNTLNALEKDCENIAFLIGEKLELDRVSNSYNLRARGKGFIFFLLGLLLPAVLLVNFLASNVSKDILVSTLGEGGAETLNLYLRPVGSMWESIPRDYHLYALIGLIVFSLLLLVLAKWSTRLKPTLNRKQKRVLNEQKDFVQNHVRATKEKLYSEYLQQSVAAHDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWS3</accession>
    <name>A0A913ZWS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056098.1">
        <property type="nucleotide sequence ID" value="XM_038200170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200170.1">
        <property type="protein sequence ID" value="XP_038056098.1"/>
        <property type="gene ID" value="LOC119728098"/>
    </dbReference>
    <dbReference type="GeneID" id="119728098"/>
    <dbReference type="OMA" id="CAWLIVS"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF418">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="35668" checksum="34425DED082C4238" modified="2023-02-22" version="1">MECTHNETDTMLPDDDDDRLSPVVIALRTAYIALNSLAIILANALTLAVMWRARGEFPPGSTKLVMSSLALSDLAVGVLSISCVPLSAMDRWPFGDTVCTLMCSVLVLFGGISIGNLLSLTLDRFVAITRPFSYPTLMSRNRVLCMTWFQWIILTVLTVIIMVTVRPRVRYNRAAAMCLIQQGQEALALDINYLCLSFILPIAAMLGIYIKLIHTTRQQAKKINTVNTASSTGGSSRAKAGSGKAVRLFCVVVIVYTICYLPFSAVRVYADLHPLARLPPAVDFVCAWLIVSNSFWNFVIYVVMNGTFRQLSKQILLEIFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXE0</accession>
    <name>A0A913ZXE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055965.1">
        <property type="nucleotide sequence ID" value="XM_038200037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200037.1">
        <property type="protein sequence ID" value="XP_038055965.1"/>
        <property type="gene ID" value="LOC119727955"/>
    </dbReference>
    <dbReference type="GeneID" id="119727955"/>
    <dbReference type="OMA" id="YRYRTCD"/>
    <dbReference type="OrthoDB" id="10068185at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000080">
        <property type="entry name" value="SCO-spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="851"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="791"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1148" mass="121940" checksum="8D07890C04FA755A" modified="2023-02-22" version="1">SAVDGQWSDWGAWLPCSQTCAGGIRGRFRKCNNPPPSGDGLNCTGYAFQQGACNTHACPVDGGWTDFGSWEPCSVSCGGGITYRRKTCTDPAPAHGGANCTGIGVENSTCGNITCPIHGGWGSWGDWTLCNTDCYKYRYRTCDNPPPEHGGDDCPGEGRKTGACSLVDCPVDGNWGAWTEHSCDSTCRGRKTRRCDDPPPLRGGKPCEGISDDSYGPCRGFDCVRNGEWTEWSPWSPCSQTCARGNMTRSRTCTNPAPRNGGKPCPTEDDSEQITSCFKQTCPVPLGYVRKVTRQGMDINFGLILGVIFGSMGGFILILLIVLGIRKHQLIKKRNKLIEEREKSKLYKEAADMSIIPEGKKSADAKLRRQQLKAKLKKNGRFGETVPLLDYGLDTEDRAFSSMSSRPGSAVSRPGSAVSRPGSAVSRPGSAVSRPGTATSRPGTASSRPGSARRRASTPSRPGTASSKPPHTESNRRSSDTAVPRTPDIAVSISETGVVTNQLPTTAGKDAASAKLKPAEPTQPATTQRVSMLRTPRPESTRPDTSLRVDTPMMMAGLKQLDAQLQEMAGCQVEHSKAAGADGGFGGIGQLMGDAGGAVAAGNTEAALAALAREALVTQHNTGKSSGGGLANLDQAMQGKKPTNQPPTTVAAAGAKSLNEAMTGTKGARVKQFAQPQAAAGGMTMTQATAGKGAQQPPTKPQRGPAAGVTVQQAMSGKTGAQGGHAQQVSPRGGVTMEQALTGGKAAGNSPRGASGITVEQAMAGKQGAQPPTGAKPKSPRGAITMEQATAGKGPQAAGGGGGYKTLEQAASGKGKGATAPRSQNKPALQREKSEVDEINENFWEVPKESIQLVSTVAMGTYGPVWRGKAWDIHGRDGMTLVTIKELKQPVSGVVKAAFMKELEVMKSLQKHPYVVNLLGCCTFYDPVTMVFEYAPHGSLLDHLRKNRPHSPGGKTPSSGEIVTFAMQVAKGMAYLSRQKVVHGDLTTRNILLGQRMVCKVSNATRVRNVVENVAEGRLGIRWMSPESICASVYTTMSDIWSFGVLTWEIVTYGSTPYPGMSAREVSNRLKVGHRMERPAHCSLELYSVMQACWDDNPKKRPSFRTLSLDLEKLLANGKTDHIDASKYDKTKYKDLDDLRPHTPGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1G7</accession>
    <name>A0A914A1G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057703.1">
        <property type="nucleotide sequence ID" value="XM_038201775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1G7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201775.1">
        <property type="protein sequence ID" value="XP_038057703.1"/>
        <property type="gene ID" value="LOC119729209"/>
    </dbReference>
    <dbReference type="GeneID" id="119729209"/>
    <dbReference type="OMA" id="CIVWPEY"/>
    <dbReference type="OrthoDB" id="5952950at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036802508" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="85"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="45477" checksum="0392E491F449BCFA" modified="2023-02-22" version="1">MQSPSWIILITQMMFLGPNTANAVFQNYFANRSDGRMETPMCDDGNTLNFSAGEDGQPNALIYNTFDRVVIVCVLPVIVALGLFTNVSFLFVVARVPRMRTVTNLYLVQLAASDLLFLVLTEIQKLVYYSASPLTMDMSVAGYAGSVALYFVVQLVHTETMILVSVVALEKYFAIFKPLHFRAHWSQGNRSRAIKMSIGTWVLSAVVVITVGPWVSDFRLTCIVWPEYSEFDGIPDRMYTLKVISEVVTTYELVTVHQRDSLWYTITFVIIASANSVLFVRIVRALNMRVMPIGPQNAVLEARITRTRNQVAWMLVVNGVIFFVLMAPRKFYDLARTISMNTGHDLLGYRPRSYILNAFSILTYLNSAVNPMVYSVVSLRYRRAFRRAFTFQQRKTTFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1J4</accession>
    <name>A0A914A1J4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057728.1">
        <property type="nucleotide sequence ID" value="XM_038201800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1J4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201800.1">
        <property type="protein sequence ID" value="XP_038057728.1"/>
        <property type="gene ID" value="LOC119729223"/>
    </dbReference>
    <dbReference type="GeneID" id="119729223"/>
    <dbReference type="OMA" id="RFSMARC"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="337" mass="37537" checksum="0AF4D25B5E81F97A" modified="2023-02-22" version="1">MGNVTEDEPLSPYLVAVRTCFVAVVVIMIITGNALSIAVTRSMPGLADSTKILMISLAAYDLLTGVMSIPNVIASAFDRWPFGEFYCSINGTIDATCCCMSITLIVLMNAERYIAVTLPFRFPILCAKRRVIAVVLIASVVSLVLQICLSYFKEDNNQFKAVLICDVVFNGTVLEISVLFFLVILPLVVLTYIYLRLIKLSQNHAVMLNKCNNAANDTSFLDNKALRAFLVVTILFAVCWTPLRVVRVVAAITDKMQPIWLSFTAKGFAVSNSFFNVFIYCFFNRSFRQAAKRLMMRYFPCFKSSTVAPMTTPILKDDTPQPAVRRKGRAAFISVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A234</accession>
    <name>A0A914A234_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3517 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057908.1">
        <property type="nucleotide sequence ID" value="XM_038201980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A234"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201980.1">
        <property type="protein sequence ID" value="XP_038057908.1"/>
        <property type="gene ID" value="LOC119729355"/>
    </dbReference>
    <dbReference type="GeneID" id="119729355"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3517" evidence="2">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="34086" checksum="35A2678E517FCA42" modified="2023-02-22" version="1">MLAVMILYCDVSKFRTIDQGDYPPRQRTLIIPTSKPLAMPSDMQQILFATEGIKYIREVILMFREVPNATTALLDMLLHCCYCNDTFTLSVMMMIHGQVSSAPTNELKHILILLLELLMMEDPLQGKRLKLAVEGNNNNGLLEIIRKCTSTDSRRSYQCIKFLVHLSNKCSMAKEYLMTISVRWQWAVNWLKKKMSEHYWTPQNVSNESSTGRSFQRTMSAQDTLAEATALLDELNTRDDDGEHIENDEEEEEYVEGDSNTKMEVNGSSEGSEVNGNEDSSESSKTLVQDDVGDLDDIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2C6</accession>
    <name>A0A914A2C6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057516.1">
        <property type="nucleotide sequence ID" value="XM_038201588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2C6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201588.1">
        <property type="protein sequence ID" value="XP_038057516.1"/>
        <property type="gene ID" value="LOC119729051"/>
    </dbReference>
    <dbReference type="GeneID" id="119729051"/>
    <dbReference type="OrthoDB" id="10135721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="118"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="41796" checksum="24A815E601310B54" modified="2023-02-22" version="1">MQYQQARNVRLPTYLSPNEVIIHRGQTQHIRCPSYIKGERVSMVFWFKGEQLLARYTHPNVGSSYASSDRYRMSHSHDLIISHVDMRDHGKYICSVVPIATTLQRRQPISVTVLTDVPSFKEAMYRKAGDACVQRNQNHHIQCPSYREGESVSLVFWFKGGQLIARFANPAFGTNFISSRHYWMSSSHGLVINHVQATDCGEYVCGLVPRATGVQRKGSVRVTVLDPEFPIVGDSEVVNKTSLILERGQGHVKLTCPALRMDQQAATVYWSLGNEETMDTSIIGVQFSDGEAMVSDDYRGDYNITDGGSLVLNTLDMPTSRFWCHVFTDQPGLFCAYYDITKTDPGSTTESATSGKVGRSDEINPQESDIFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2N2</accession>
    <name>A0A914A2N2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057859.1">
        <property type="nucleotide sequence ID" value="XM_038201931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2N2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201931.1">
        <property type="protein sequence ID" value="XP_038057859.1"/>
        <property type="gene ID" value="LOC119729310"/>
    </dbReference>
    <dbReference type="GeneID" id="119729310"/>
    <dbReference type="OMA" id="PPLDQQM"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11864">
        <property type="entry name" value="SH3_PEX13_eumet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="302"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="50584" checksum="D3D0BD82038426FD" modified="2023-02-22" version="1">MAAPPKPWERGAGQHNQGSFSSVGDFGPTLVSQHSSTSGLPIPGSSSAGPAVSRAPPPLPTRPSQQGSAFSSPVNRYGGLGYGNSYGSGYGGFGNSMGGYGGMYGGSGLYGGGSYGGGMFGGGGHFGQGQFGRGGDPAGYNQFLRQAEENSRPAFQSIESIVQAFGSISMMMESTLQTVYNSFRAVIGVADHFSRLKVHLAHIFTALALFRTLRYIYRRLLAFLGLRSREFAEELWEKAEGTTEELVGKMEKLNGKKKKGAPSWPIFMFFAVVVGGPYIIWKLLCSTEDDTQDQPAWASGEEDHVVARAEFDFEAEGSNELSFKAGSMINLAPKEMQPKVRGWVLASVDGQSTGLVPANYIKILGKRRGQKSLAGLEVQPGESTQQPETIPEKPVVVSSTGQPGSTGQPALPTTQSELNLAAFDKAFTEAPSSSQAAEGAVQSSMDTEWSAWESNQIGDTTDKTTEEVDSLENTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A378</accession>
    <name>A0A914A378_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058049.1">
        <property type="nucleotide sequence ID" value="XM_038202121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A378"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202121.1">
        <property type="protein sequence ID" value="XP_038058049.1"/>
        <property type="gene ID" value="LOC119729501"/>
    </dbReference>
    <dbReference type="GeneID" id="119729501"/>
    <dbReference type="OrthoDB" id="10135721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862865" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="148"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="406"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="589" mass="65080" checksum="C7361688DF5CBD1B" modified="2023-02-22" version="1">MADIRLAGIIVVILVSLNVSLAQTVSTSDPFTASPAGNVKLPTYLSPNEVILHRGQTQHIRCPSYNNNERLRHVIWFKGEQLLTRYTDRKVDSSYASSDRYRMSHSHDLIISHVDMRDQGEYVCSVVSSATALERRQTISVTVLTDVPSFKEAMDLTAGEVYVHRNQTHHIQCPSYREEESVSLVFWFKGSQLIARYANPEVGTNFISSRHYWMSSSYGLVINQVQAADEGDYVCGVVPSATGVQRKGSVRVTVSGPTFPIVDNAQVVNILEKGQGHVKLTCPVLRMHKQAATVYWSLGSGDTMRTSIIGVKFSGGGIMVADDYRGDYNITVGGSLVLNTLDMPTSRVWCHVFLHHQEMSSAYYDVIETDESEANQSIMPREPASVATKWTEEGGVVTVTVLQDPPSAVTLHVNTTHSCESDTECSADVTIGSRYRFACNASGSNPASNITWLINTKARSGMGQTEIPPDWSQSRQDESNEDWETSSRIDLQILPEHHQGSITCRAMFPDGGTVFREMTVKLIADDKHEVLLLAILIPTAVAVFIVGVIATVCKLRSNIKRERARSYRGKEAAIENYSGKKLPTISVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4D3</accession>
    <name>A0A914A4D3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058550.1">
        <property type="nucleotide sequence ID" value="XM_038202622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202622.1">
        <property type="protein sequence ID" value="XP_038058550.1"/>
        <property type="gene ID" value="LOC119729827"/>
    </dbReference>
    <dbReference type="GeneID" id="119729827"/>
    <dbReference type="OMA" id="MENTIQP"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15470">
        <property type="entry name" value="Myo5_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="1">
        <location>
            <begin position="149"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="453" mass="52676" checksum="A2982F7C3697F38F" modified="2023-02-22" version="1">MKRRWGSLEIYQAVVKRKERLEIPAECPDTSLAELMAWCWDADHRQRPDMKEVHQFLVEFDATDASNYPNVTKQNNRCITPLSTGQHQQQDADSAGHREHEKREILGMLELSSQECGESSTGLTGLHHLHVHTSRGRYQRRSKVKVLLTGVINGIKKTVKNHFEDFEYVSFWLTNTIRLMHTLKQYSGEDKFASQNTHRQNEHCLRNFDLSEYRQVMNDLGVHIYQMLVHIIENKLQPMIVPAMLTPLGLMRGHITIESLIKQLTTFLTVMNNHGTDPEVVKQAIKQSFYLVTASTINIILLRKDMCHWSKGVQIRYNMSELEEWLRSSRLYDRNMEETLEPLVQIAQLLQVKKRTEDDVRLICETCTKLTTTQVVKILNLYTPDKYEEKTEVSFIRKVQGKLAGRMTPKKDAQLLLDTKYMFPVTFPFNPSSVLLNEITIPDTFKLDCVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7M2</accession>
    <name>A0A914A7M2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059425.1">
        <property type="nucleotide sequence ID" value="XM_038203497.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059426.1">
        <property type="nucleotide sequence ID" value="XM_038203498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059427.1">
        <property type="nucleotide sequence ID" value="XM_038203499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059428.1">
        <property type="nucleotide sequence ID" value="XM_038203500.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203497.1">
        <property type="protein sequence ID" value="XP_038059425.1"/>
        <property type="gene ID" value="LOC119730530"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203498.1">
        <property type="protein sequence ID" value="XP_038059426.1"/>
        <property type="gene ID" value="LOC119730530"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203499.1">
        <property type="protein sequence ID" value="XP_038059427.1"/>
        <property type="gene ID" value="LOC119730530"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203500.1">
        <property type="protein sequence ID" value="XP_038059428.1"/>
        <property type="gene ID" value="LOC119730530"/>
    </dbReference>
    <dbReference type="GeneID" id="119730530"/>
    <dbReference type="OMA" id="FFWIGHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="311"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="722"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1345"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1580" mass="174749" checksum="A0524B8B8CF4F477" modified="2023-02-22" version="1">MGEMAMLDPQWEWFCGRNSSDLSRSSGDWLGNTCFVDGLSVLPHAAFLVLSSLLLLVLGCCSGYRKIHTRYLIMHPGHELRWLLGAVTILVFGASIGEGILTDETYRAFGQATQPHLYIYGSTAFLASILALIYYHHMELWQSPAMSLLLLVYWLAAAGGEGIRMASLEYQKQIDFNVVRFDITVLLLVCFGLLFLIEVYGIIVKLFKCFGSASDEDLHEDLKNSNMRYMNYNVNLASYLSYWWVNWLLAVGYKKPIQIEDLGDIPTRHRARLNHQIFRRAFLEEKAKAQRKGKSPSLLKVYVKVYGWRILGAAVLKFIADVLALIGPLCVGGITSYVISIVYPTGEPQPQPHSVTITEYFANGFVLVAVLFLTSVSRLTCLQTNFHWTILESVNVRTALQTMVYEKALRLSTYATTGGKMTMGQITNHMSTDAMAVLYMFQTFHYLWAIPIQITMTLVLLYFQMGFAALLGFAVFILVVPIQLKVTQVLTQRQKDILGCSDKRLKQSNELLQGIKLLKLYAWEHIYGRAIEVVRKQELGFLRKINFALIVTMLLTSATPILVTLVAFGTYTALTGLPLTPDVTFSSLALFNQLGIPLFLLPISLAMTVNAVVSTNRLRKFLLAPEVEGNESALIDGEKLPVIKSANGQEANVEFRQPGEVTNGGKLSTHNTIGIQTGDDIELVSYGNNATDSNGNPGKEGVVNGAFIAPKDGDGLKPDIAVKITNGNFIWDPEGSTPVMSDINIEVPAGKLTMIIGQVGCGKSSLLSAILGEMTTLSGKVEINREKGSIAFAAQKPWLLNASLQDNVLFSKEMNRRRYKDVISACALKPDIDILPAGDQTEIGEKGINLSGGQKQRVSVARTMYSGRDIIILDDPLSALDVHVGRHLFDEGIVNWLLSNNQTVILVTHQLQYLSRADLIIEIKDGRVAAMGSLDDVIKADPETYSSWQQEVEEAEGAGSDSEQVVEAEEERQVLKRQLSKRESFVKQISKDEEKSGGKLIEKEEQARGSVSIKVYFYYLRSAGWGLVAFVLCMTGVTSALSIGNSFWLSAWSEAGLSNESATTTAEYLGGYAGLSISIIVGQIVSYSLLVIAALVAAKSLHQNMLRNIIQVPLRFFDTTPIGRVLNRFSTDTQLIDSRLSQTLNSLLQCFMQCLAAILVNTIVMPFFIVFIVPIAIGYYFLQKYFITTSRELQRIDSTSKSPIFAYFSESLGGLSTIRAYGDGKRFYDTLISRIDRNLGPYLYLQAANRWLGFRLDFIGSLIVLLAGLSTLVGALTFGVDPSLVGLGITYSLQVSGYLNWLVRNVAEAELQMNSVERVKFYTDVENEPYEGKEPASDWPLEGEIKFEDVSVRYAKDLDAVLKKVSLCFKKGEKVGICGRTGSGKSTLTLALLRVIDIFEGRVLIDDVDIMTVPLTTLRSKLSIIPQDPVLFTGSVRINLDPEMKKSDDDLWQALEIAQLKEVVSQLEGGLDAKVTEGGENFSVGQRQLFCLARAFLRKSRILIMDEATASIDLETDKILQSVVATAFADRTVLTIAHRIATIMDSDSILVLDDGHLAEYGSPSELLANENGMFTSLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7Y9</accession>
    <name>A0A914A7Y9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038059898.1">
        <property type="nucleotide sequence ID" value="XM_038203970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7Y9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203970.1">
        <property type="protein sequence ID" value="XP_038059898.1"/>
        <property type="gene ID" value="LOC119730906"/>
    </dbReference>
    <dbReference type="GeneID" id="119730906"/>
    <dbReference type="OMA" id="LSMIVWN"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="308" mass="35907" checksum="76820E71C6702224" modified="2023-02-22" version="1">MLDHIDPVFQQAVFSFEEDFDHRPWVKIMETHWVDSIYASMIYVVVIFGLQWFMRDRAKLDLRRPLVLWSLGLAIFSNLCAFRLWQELFLYKNLYGWKSTMCEADIGYSGVNGFWSLLFVLSKLPELGDTLFIVLRKQKLIFLHWYHHITVMVFSWYSYPLLVAPGRYFILVNCSVHAIMYTYYALRASRLVRIPRFINVSITLIQMSQMIVGVVVNTLAYYYRSHGDFCSTTDRNLHVALLMYSSYFFLFAHYFYQAYFVRAPAKPSPKPALEKESNGVAYSNGVHANGAKHSNGVHANGVNTFKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8V9</accession>
    <name>A0A914A8V9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059860.1">
        <property type="nucleotide sequence ID" value="XM_038203932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059861.1">
        <property type="nucleotide sequence ID" value="XM_038203933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8V9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203932.1">
        <property type="protein sequence ID" value="XP_038059860.1"/>
        <property type="gene ID" value="LOC119730869"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203933.1">
        <property type="protein sequence ID" value="XP_038059861.1"/>
        <property type="gene ID" value="LOC119730870"/>
    </dbReference>
    <dbReference type="GeneID" id="119730869"/>
    <dbReference type="GeneID" id="119730870"/>
    <dbReference type="OMA" id="QGNSCME"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324116" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="214" mass="23394" checksum="ED9AB686B5D77A68" modified="2023-02-22" version="1">MSIKSVVFLLLVVVATSYAQTKCCCPDQFEMNEGVEVGMSQAGKGSAVFESVRLAFDYTNKRIGEIGTVIIDGEASQVQVILDYNKGVGYSIDLKTKQCQKMPVPGPMLHCVPDNATYQETVYLGDHKLTVDSFGISFKTGTASLSVSKTDCIPNSFNVIGQFGETALLAVTGFYNYSQGIKNPSKYFTVPDYCPKSFTEEPVFGNRPSYKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9R1</accession>
    <name>A0A914A9R1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase-like 2</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038060149.1">
        <property type="nucleotide sequence ID" value="XM_038204221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9R1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204221.1">
        <property type="protein sequence ID" value="XP_038060149.1"/>
        <property type="gene ID" value="LOC119731167"/>
    </dbReference>
    <dbReference type="GeneID" id="119731167"/>
    <dbReference type="CTD" id="8999"/>
    <dbReference type="OMA" id="NINHYNA"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07846">
        <property type="entry name" value="STKc_CDKL2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000261">
        <property type="entry name" value="cyclin-dependent kinase-like 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="318"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="613" mass="68927" checksum="C07E6CD9BF79BACB" modified="2023-02-22" version="1">MRTLTAMEKYENLGLVGEGSYGMVMKCRHKETNQTVAIKKFIESEDDKMVKKIALREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFVDHTILDELERYPNGLEDNVVRRCMWQVLKGIDFCHNHNIIHRDIKPENILVSKSGIVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAVDIWALGCLQAEMCTGEPLFPGDSDIDQLYHIIKCFGNLIQRHKEVFMKNPLFVGMRLPEVRNVEPLEKRFPSLTGLSVTVMKSCLHLDPDERPTCSQLLRHDFFKKDGFDEKFPSELRVKIAKEFDCNPLLRPSGEEKEGGGEEKKKSKKSKKDQSHSHSDKEREREKYKKRHSDADRHKISSTPPDVSDKHPKVSSEGHRKYSDASDPHKKTSSKTGSGSPIPTITPTSKMLPSTVTASHNSSSNPPLQSQGGSSSQAPISTINVGTIGASKGSHTSNNTSGPPHLRASDKVKKGTTNTYYKKPAQPPPAHHSTSMTTPVQSEKTMLHERTLQFDVLMASQRKSKGTSSPKLEREITHLPNLAGLDVDSNKRSDKKPKIKKSQHTPMPHIGLHNDPGHSGANGSHLNQSSSADDFREHNLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD64</accession>
    <name>A0A914AD64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061416.1">
        <property type="nucleotide sequence ID" value="XM_038205488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD64"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205488.1">
        <property type="protein sequence ID" value="XP_038061416.1"/>
        <property type="gene ID" value="LOC119732100"/>
    </dbReference>
    <dbReference type="GeneID" id="119732100"/>
    <dbReference type="OMA" id="ETWKENM"/>
    <dbReference type="OrthoDB" id="6220511at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34201" checksum="323CCAD52E9CAA4C" modified="2023-02-22" version="1">MAAPTENPVAGVCERKTQSNLQISENMTDEGRSVRVEKNESHLANTFQMCTDFIDEHIRLFRTSISVTAAIGLLVIARSIRVYQRFRRVSDIPEEFISKNMKLYGRFVALRKEPVHVIVQHTPIVNFEWRQKRESDSGSGLPVHLAGLELQEGSLEYLQDRLGTQPSLRFHMLCVNEANGLDCIVDLVKWKLPFRRTSLNEELLRQGLAKVSPLGGLRDHKLQTRLTQRLLAAELRAEKKSRGVWTREREPTKLDVARAGLVKVRDGLTSGVAVLVKVVTLPWRGLSNLRDFLRRKSDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD80</accession>
    <name>A0A914AD80_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061698.1">
        <property type="nucleotide sequence ID" value="XM_038205770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD80"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205770.1">
        <property type="protein sequence ID" value="XP_038061698.1"/>
        <property type="gene ID" value="LOC119732313"/>
    </dbReference>
    <dbReference type="GeneID" id="119732313"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41449" checksum="9A8713A318DF669C" modified="2023-02-22" version="1">MAQSILNRLELFRIIFIMCQGAALFVSGFETSYAGKHTFYASENCALKELAYSNKIVRSRVICGRECSMDERCKSFNFNDCNKMCELNLATRREHPEDFNATQGSVYFDTDEDTPLYSLTDSSFDRYRSCKMLLDAGYRSSGVYTIHTEGFGHCSLLVYCDMETYGGGWIVFQRRQDGSVDFYRNWAEYQSGFGKLSGEFWLGNDNLATVTSDDSRGTWELRVDLEDWENNTAWAKYSDFQISPGEYNLNIGQYDVNSTADDSLRYQSGHYWYRRGHALQYHRGRPFTTKDRDNDASDHNCAEKFAGAWWFNRCFFSHLNGRYYPDTNAGSNQGVQWSAWKRRYSLKACSMKMREIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADY5</accession>
    <name>A0A914ADY5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061564.1">
        <property type="nucleotide sequence ID" value="XM_038205636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205636.1">
        <property type="protein sequence ID" value="XP_038061564.1"/>
        <property type="gene ID" value="LOC119732203"/>
    </dbReference>
    <dbReference type="GeneID" id="119732203"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="315"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="394"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="56119" checksum="00F2459CBA3584D3" modified="2023-02-22" version="1">MITSTTRFDDSSVERRDAMLHLLDPASAAVLDDPKYGPVCVQSSSTRRFECRIQDARPGVWNFTWMLGNQAIATKSEAWTGAGLVNVSSWRIVTNPGNETRERNLTCLAASSDQSLSTRVLITPCADALVKGSKGVLIAIVTVVSVLSALVVMAIVMFVKFRRNRRAQRSVQIKRDAQSSVEMDVALDQDALEQPCPSEVGSSPDVKYEDRIAPKGPHKYKDRIAPQGSHKYEDNIAPQGPHTYEIKISPQDPHNYEYNISQQVAHQYEDTSSPQVEYDDTIPPQEETPMLPDGDDDNNLPPWAEGWKVPRCDLIMDERVLGRGNFGEVRSGAVMKDGELTRAAIKMLKGHASTSEKDDFIDELRTMTSFGHHPNVVSLLGACQHRQVLYVALEYLPRGDLRSYLRTARSQSDSDEDALSSDQLVKFALDVAKGMEHLAKAGVIHRDLAARNILLSEGLTAKVSDFGLSRGEDIYVQTSKRRVPVRWLAVESTRYKRYTTKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF67</accession>
    <name>A0A914AF67_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-conjugating enzyme E2 J2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038062013.1">
        <property type="nucleotide sequence ID" value="XM_038206085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062014.1">
        <property type="nucleotide sequence ID" value="XM_038206086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF67"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206085.1">
        <property type="protein sequence ID" value="XP_038062013.1"/>
        <property type="gene ID" value="LOC119732529"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206086.1">
        <property type="protein sequence ID" value="XP_038062014.1"/>
        <property type="gene ID" value="LOC119732529"/>
    </dbReference>
    <dbReference type="GeneID" id="119732529"/>
    <dbReference type="OMA" id="GWSVATI"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="241" mass="26994" checksum="E81A8EB23A709E5D" modified="2023-02-22" version="1">MSKRVSTTATARLKQDYTRIKKDPVPYVTASPLPSNILEWHYLVRGPEGTPYEGGLYHGKLVFPREFPFKPPSIYMITPNGRFKCNTRLCLSISDFHPDTWNPAWSVSTILTGLLSFMVEKNPTLGSIETSDYTKRQLAVQSGPFNVKNQTFCELFPDVALEVRETIRRREEEIRQSTESASLRGQSSRQANTQDGQLPLPHQGPQGIVGSTLANVLVIVGFAAFAYTVKYVLKSIAHTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFA5</accession>
    <name>A0A914AFA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038062054.1">
        <property type="nucleotide sequence ID" value="XM_038206126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206126.1">
        <property type="protein sequence ID" value="XP_038062054.1"/>
        <property type="gene ID" value="LOC119732557"/>
    </dbReference>
    <dbReference type="GeneID" id="119732557"/>
    <dbReference type="OMA" id="TDINAFF"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="12">
        <location>
            <begin position="445"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="655" mass="74043" checksum="DB0AE37D5B6DF888" modified="2023-02-22" version="1">MALERGLSDDSLVDTRTNNLASSLGSMSQVDESIREAIQDTKSTLCSATPLTPVGKRKQMIKMLTLTLMPIVVLTALAISDLIATLTKSIDAIEIRRNVRFSRQVGTLVHSLQLERDMTALYISSLMQQRTTGPQRKIFLINTYPITDEVLENLDDWPVAGTVAYQQFQNKEAFMSFLFEYRLTLDIHNTTIYEVIHFYTDAIQLFIDWLYESVGKSGGQGLWETLVAYQLLIVGMEQTGIERTLGAVFYTQGGFDKPTDYRWYMEKMQVGKSNIWASQKYSELVREILEGKVQEFEYDYEEIINTMREEISYNNASREPSWQEGTWWFDNMTIYIDTLKDIQRRMAEVILTKLNSAVTTDNADLAVSICIMVIVVIMCVIIIKAVESLTANMQVNARTLADQTRALNKERKRTDTLLYQMLPKSVVVSLKHNQNVRAENFAEATILFSDIVAFTRICSESNPLQVVEMLNNVYTNFDSRIDKYDVYKVETIGDAYMVVSGLPQRNGNKHASEIACMALDLQKCIEELVIPHKPGTKMTLRIGMHTGPVVAGIVGSKMPRYCLFGETVNIAAKMESNGLPNRIQVSEDCARILTIINSFCMAKRGEMLIKGRGTMTTYWLLGCVKDADSSNFDANRQGLNLHVPELPNPAIVDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFF9</accession>
    <name>A0A914AFF9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hypoxia up-regulated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062458.1">
        <property type="nucleotide sequence ID" value="XM_038206530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFF9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206530.1">
        <property type="protein sequence ID" value="XP_038062458.1"/>
        <property type="gene ID" value="LOC119732946"/>
    </dbReference>
    <dbReference type="GeneID" id="119732946"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903298">
        <property type="term" value="P:negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000012">
        <property type="entry name" value="Hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="659"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="798"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1199"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1223" mass="137776" checksum="24CFA8C37A27A2CB" modified="2023-02-22" version="1">MFSTQLVEKPQASIMNARASLLSLAVAILVTANHIPGSASLAVMSVDLSSEWLKIALVKPGVPMEIILNKESRRKTPVMVSIRNGEVQFGDDALAVGTKYPQNAYFYMQHILAKRLDSPAVRNYIHRFPYVELGEDEERGTVYFKSGEDRYYPEELLSIVLNKSRALAEEFAEQKVKDVVITVPPFFNQVERQTVMYAAELADLKVLQLINDNAAVALNYGVFRRSDFNASKHNVMFFDMGAGSTTATIVTYQVVKTKEKGFSESNPHLFVKGVGFDRTLGGLEIDLRLRDHFARKFNKLGKTKKDVFESPRAMAKLFKEANRVKKVLSANVDHMAQVEGVLDDVDLRLKVTREELETMCADLFERIAGPVEMALKTSEMTMGEIDSIILVGGGTRVPKVQEKLLQVTKKSELAKNINADEAAALGAVYQAAHLSKGFKVKKFVVKDANLYPVQVEFERQITDDDGTEVTRVVKRTLFGRNNPFPQKKVMTFNRHMTDFSFVVGYKDLEDILPPGDLKSFGSTNLTTYTLKGVDAALKKRSDAEPKGIKAHFRLDDSGLLHLDSVESVFEKTETVMEEVNDTEEEQSTLQKLSSTISRFFSGSSDEGTSEVPPQEGDKAAENGATEEETDEKDTSDKDISEKDATESKETEEPKPAEDEKVEEQTADDTQETTDEQKEEDDGEMKEEDATEPTPEDEGVKDEKTAEETEEETKDETEENGEEETEKTDEDKADEETADGEKADEEKADEEKANEETADEEKTDQETADKEKSDEEKADEEKADEKTDEEKTDEDDEKSSDADSKDSDAKPESPEKDEPEEKKTEESKKKTKKDKKKDKKKDKKKDKKKDKKGKKDKDSTEDKVKKEKKKVAKPKQVTMKENLTVESQVHGIPKPSREARKASRSKLNELRKKEEERLARETSLNALESFIYDMQDKLDQEDYEKCSTEEHREKLLAKLREASDWLYEVEEDAPHTVFQDKMKELKKATKNLSFRVKELRERPQLISELKQLQNVSQIFLSAAKNASAEIQIFTDVEMGLLEKAYNDSMEWYTEKSLAQRNTPDTEKPVLLTDDLKTKIVSLDRELRYLVNKAKAGPPKKKDKPKDKPKKKKNKKSGNETETIGDEDINGEKKINDTESSVPTEKPAVTKAEGEPEVPETISPDADQAQDETVEEPLQLPAPDDEGTDNVESEQPKTEGEAPTETTTTTTEETNTDTSRNTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFH7</accession>
    <name>A0A914AFH7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062492.1">
        <property type="nucleotide sequence ID" value="XM_038206564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206564.1">
        <property type="protein sequence ID" value="XP_038062492.1"/>
        <property type="gene ID" value="LOC119732981"/>
    </dbReference>
    <dbReference type="GeneID" id="119732981"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="343"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="996" mass="112322" checksum="454762F34D9C6890" modified="2023-02-22" version="1">MKALEADANKPAEKRKAEATALKDQGNQAFKKSNYTRAVELYTQGLERLKDFVVLYTNRAQAYNKLGKFTEAMEDCRTALQLEPNNVKALVHLGKAQQGLKDYEVAVTTYKEITKIDEKYESKVAGYIAEVNLAESTAKSDMEAERLLSEGDVKATGVHEIGLGDVTDSQAALTQQLPDDQQTTQSGSGQPSQQEPTQQPPPQLQPRPDYPQRSEAIIGSISGSQNPVIVGSNEVNIIYNKLSEGPETTGLQESGTFEDLQQEIIDNYEQTATTIPAHPTLQSRNVGIEEFFIPLNLRKNISGKTKSERLVTLLKQNIFLDEAQKIILKSVDDLFNQKIVKEIKILLYGGAGTGKTTLLVKVVNSCITLSSEPLLGRFDLVLWIKLRQMQSNSVLDAIFDQILPIDTKLDKTTVQRIIDGKQSRIALLLDGLDEIPSHVLQSKEGVYRVQDILHSRVLTKSFVLVTTRPHMMEYVLEGSNPYAVVETCGFRPQDRDQYIRLNLSDDSDMGEALISHLEDNANLKEMAVIPIISQMLCLVWKNEKSLPERITKLYEKFAVVLFKRCNKDMNDDQVMLNLMPIIDDLGRVALQGLLDSRGERLMFNETEFQDCPSCLAEGCRVGFVLRETFTSGLDVKVLVTFPHKSIQEYFAACHLVKLLQQDDENNFRHQLEQIGEGNVFAMEYLLRFCCGRSMQAAGLILDHIQEMQGDEMKLQRLARLILCESGSKELATKLVRPTRVECESNADLKSLSYYLKRVTPPLKNTGFYMHVRKQDLNLFREILLMSDSMESAKMIFVHYMLSEEEKEDFSPLEKTIGVRKEERRAQLHIMFYIGEKSLFDMGPASHSFLRMQEKIMPSLSMIKVRPEEVVDVLQVLEECRFNYLYLHSINLHGQLRDVHILPAIGTLHLEKCRLVDDDVKDLISILPAGRGLIGLTLDDSAFSLDAVRALIGHLQGFPKLCRLGLHNIGLDAQLIRQVVSQGLPHLKETAEGDFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFL2</accession>
    <name>A0A914AFL2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038062291.1">
        <property type="nucleotide sequence ID" value="XM_038206363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFL2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206363.1">
        <property type="protein sequence ID" value="XP_038062291.1"/>
        <property type="gene ID" value="LOC119732718"/>
    </dbReference>
    <dbReference type="GeneID" id="119732718"/>
    <dbReference type="CTD" id="201973"/>
    <dbReference type="OMA" id="HYEVIQD"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="65511" checksum="BCA4C2E594CBBD56" modified="2023-02-22" version="1">MALIDQKKRKEKQWEERLKKLQAVEAWYQTYPIIPAYRPCLIDPSPFWHTVYRQKHAFDVAAAHPEDVHVFAFEADNIKPDTASKGQRKYVITTYLQLWHTIYHLAAHGKYPTFYEVIPEGSACKLYFDLEFSRSLNPECNGAAMVQTLIKFVCAELMDVYQKQCGVHHVINLDATTDNKFSRHLIFNLPQTVFKDNVQAGNFVQHVCQKITRISQTTESDGEPEAKRQKHEDKTEGNRVPDSQRQHEVSLYQNLFVQNKDGQSSLFVDQGVYTRNRNFRLYKCIKFGKANPLLIAEDNKYKPRITSKSGTSQAARDSAMERHFFLDSLITNVSYCPGTHVLTMERNEGSTPKGSRPSNNKTTLAQEDPSDLLEGFNHSPYPDLDAFIYTVITNGGIQGEIRRWVYFTQGQLLVYDIIKNRWCGNIQRQHKSNNIMILVDLRRGVYYQKCHDQDCKSAGYKSPDTPLPTELLPTLGDDLDDDELLAAVTAVEGRESAPHDMTGLDNTVTELSDEELLAATLQVEGNMSSRTDQCDDNNERVVTSSDGIGNDRGNCGDVTESDEELLAAMADAEHSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFP2</accession>
    <name>A0A914AFP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062321.1">
        <property type="nucleotide sequence ID" value="XM_038206393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206393.1">
        <property type="protein sequence ID" value="XP_038062321.1"/>
        <property type="gene ID" value="LOC119732788"/>
    </dbReference>
    <dbReference type="GeneID" id="119732788"/>
    <dbReference type="OMA" id="HARPEHE"/>
    <dbReference type="OrthoDB" id="2441813at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="93"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="253"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60531" checksum="FC7EFE9C0AD9A0CF" modified="2023-02-22" version="1">MKKILGLSSPARLLWEQQKESALKGKQMRWHPAIIRWCIALQSKSSAGYGLLRDSGFLKLPHPSTLHSYSHFASLTTGLYASMLARIYQDWHLETVPEFERNVSLLFDEMKVKAGLAFSVRSGKIMGFTDLGSVANEIAAFERRCRGDEEPTIATHVMVLMVRGIFSSLRAPVAYFPTTGITGDQLYPCMWEAVLWLETAGLQVRGLVSDGASPNRKFYRLHGESSETSVPTYCTPNPFDPNRKIFFLCDVPHLLKTTRNNFENSGYNRQTRTLCYHKQDIKWTQLLQLYEWDVGLDRHSPGLRRLHKITYEHLHLTPSLRMRVYMAAQVMSSTVANTLDAQTKAGKVGLESTIKFIRYIDDFFDCLNVSNAYDYARLRKPNLEPYISAEDKRFDWLMHDFLGFLDEWEAEVESHPALDKTAKAKMILSKETLKGMRITVHSFVELGRLLLKLPGVTFLLSEKFNQDPLEQYFSKQRGTGGCSDSPTVEQFGHNMQALYVASSCVKASKRGNCKVQGADEVAALDSTPLPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ84</accession>
    <name>A0A914AJ84_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063781.1">
        <property type="nucleotide sequence ID" value="XM_038207853.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063782.1">
        <property type="nucleotide sequence ID" value="XM_038207854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207853.1">
        <property type="protein sequence ID" value="XP_038063781.1"/>
        <property type="gene ID" value="LOC119734364"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207854.1">
        <property type="protein sequence ID" value="XP_038063782.1"/>
        <property type="gene ID" value="LOC119734364"/>
    </dbReference>
    <dbReference type="GeneID" id="119734364"/>
    <dbReference type="OMA" id="HRTVMPY"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MADS-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="602" mass="66704" checksum="85A20FD52AB80D56" modified="2023-02-22" version="1">MRFIENPDLREWVKNSLRRAVFQKAHELAVQTGCEVMVKLQDSTSYSSQYYATQTLHLQYQGKGLCKQPWDIKVSGLTGLPEAVLVERGCQIGGKENVKADLRVKEEIDVAESSMQDQEPKQAGSFERASGILSADSDSQMDCEKRVDSCPPDYRADKHDTSQAASRSFIQPDRDSKSNVPYERNEPIPGGSGPGESYASYEAQPNAGLGFEDKDGAVPTSTDLFRTAATYSIGFPINKFQAQTKSVNARTIFPGQVLDDLEAQNAAPAVMQNAGGADDADKPALKPYQCGICRKTFGSIQFLSRHGQVNHGLDKRMSFSCDVCGQSYKIAKHLQRHMRMHHSVMPYICPICNKGFFNGTSLTKHVKVHEQLNEGNQFLAAQGSRTSSQDFSPPEMSTSENQQPEGHVTEDTTDKIPGEAVELGDYPANIPSLPGPSRTIPIFPQNAQNHGEDQCDTKHPSSSEEQNQDGEGRSHQMSWQDASLASDDSNRNTSDSSAAVTQGGIQQITYIRNLGLFSTGHLCHLCGKSYKYSSTFKEHLLTHSSVPRFTCKICGEPFTRQRQFRDHMIHHTGTYPYHCVVCGKGFIRPSIMKKHQCVEQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJV9</accession>
    <name>A0A914AJV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Notch</fullName>
        </recommendedName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063704.1">
        <property type="nucleotide sequence ID" value="XM_038207776.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207776.1">
        <property type="protein sequence ID" value="XP_038063704.1"/>
        <property type="gene ID" value="LOC119734333"/>
    </dbReference>
    <dbReference type="GeneID" id="119734333"/>
    <dbReference type="OMA" id="TCHEQRD"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000142">
        <property type="entry name" value="Crumbs cell polarity complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000080">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000125">
        <property type="entry name" value="Neurogenic locus notch protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008297">
        <property type="entry name" value="Notch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024600">
        <property type="entry name" value="Notch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010660">
        <property type="entry name" value="Notch_NOD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011656">
        <property type="entry name" value="Notch_NODP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF23">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06816">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07684">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002279">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01452">
        <property type="entry name" value="LNOTCHREPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01334">
        <property type="entry name" value="DUF3454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01338">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01339">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0010">Activator</keyword>
    <keyword evidence="15 25" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17 24 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 26" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 28" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037550127" description="Notch" evidence="28">
        <location>
            <begin position="29"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="696"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="734"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="772"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="810"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="848"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="888"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="927"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="965"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1003"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1041"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1079"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1130"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1167"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1205"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1243"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1281"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1321"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1359"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1399"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="30">
        <location>
            <begin position="1532"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="1919"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="1963"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="1996"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="2030"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="2064"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
            <begin position="2097"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1800"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1861"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="2160"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="2338"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="2427"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="1878"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1895"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="2160"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="2235"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="2342"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="2360"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="2427"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="2449"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="2477"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="2526"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24 26">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24 26">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24 26">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24 26">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="857"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1269"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR002279-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR002279-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="33">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2581" mass="277408" checksum="64C4CD2954DADCF6" modified="2023-02-22" version="1">MGRKLGPDFKMPRLDLILVVVLINTVLQCTTVVRASCGPDTCLNGGACVANPGSVSQCQCPDTHFGASCEYDNPCRHNRCLNGGTCQIVEPTDGDSQPTFSCLCDVGWTNSLCELELPNVCRDEQPCQNGGRCNLRGSVDDYTCACSEGFTGRNCTMTDHCVGNPCKNGATCNSHATGYNCSCTIYYRGTHCDIDINECTAEVTACHNGGTCGNLVGSFICTCSQGYTGRRCESIYTPCRPNPCRNGGECNPLGMYSHECICPAGYTGTQCETNIDDCIMHQCTNGGLCIDGIDSYTCSCAPEYTGELCTDDVDECTLQPNLCRNGATCRNNAPGYRCTCVYGFEGDHCEHDVDACETNLCENGATCEDAVASFRCICAAGYTGLYCHLEDACISSPCAASSTCDTNPGTGDAVCHCPGGLTGSDCSIDIDECEYDPCESGHGSECVNTVGAFYCNCAPGYSGLRCEVDIDECASTPCVNGGTCLNLAGMFNCVCVRGYTGVYCETDIDECASNPCLNDGFCLNKVGRYQCNCLEGYTGARCEANINECLSDPCQNGGTCLDGANQYTCSCLPGYTGVDCETDYDDCQHDSCFNGRCQDALNGFTCICNLGYEGRLCENQIDECLDEPCQNGGTCIGLVGAYQCVCAPGTTGATCSINTYECSSNPCQNGGLCNDLINGYECECLAGYEGLLCEVNIDECASNPCANGGTCHDDINKFICTCPSGYHDALCFSSINECESSPCLNGGTCQDGVNEYACECVRGYGGPRCNADIDECASNPCQHGGRCASGLDYYVCECPEGYAGTNCESNVDDCVGYPCRNNGTCIDAVNSFECVCIPPYTGEVCEDLLQPCENHRCENGATCEPFPSYNGYSCRCPNGYTGEFCNRDIDECGEYPPCHNGAICNNTFGSYECICPPGFGGQDCITNIDECESDPCQNGAACFDKTNDYTCACLPGFTGKNCETDTDECESNPCRNGATCHDYVSSFTCACTLGYSGVYCQTNDMDCTESSCLYGGTCIDGVNEYTCHCTPGHVGPNCQYQVDECSSNLCQNGATCVDHTGYYTCNCVLGYLGENCQDLVDWCSAEINPCSNGATCTQTDNRYTCTCEGAWAGSLCDVHQVSCDVAASEKGVTVENLCLNGGTCQTHGNSHICQCQPGFRGSYCETNIRECASAPCQNGGTCRDGVNEYSCSCVAGFEGLNCENNVDECASSPCMHGGVCHDLVNSYSCSCKSGTEGINCQINNNDCFSGACFHDGTCRDLIGSFTCDCPAGYVGQRCEGDINECLSMPCHPAGTSSCIQKVNDFECVCNLGYEGRLCDTQVRYCDSNPCQNEGTCTITRSGFHCQCTQDFKGNICGEPVTMCDANPCQNSGTCRVDPDNQVGYICDCPADIFGDNCETRDPCRAGPCAHGGDCLLQWESYVCRCPATWSGRRCQVFDPDFPGGIGSDPVLPTTPALLVPTTAQRPLIPTTAVVVTRTTRKETPTPPMNNDFCSASCVQRKGNGVCDADCNNHVCNWDGTDCTYGVNPWINCTVSTVKCWELYSNGECDEICNNRDCIYDGFDCERKLPDCNPVYDAYCHENYANDACDGGCNTAECVHDGLDCDDRPPMFAKGILIVIVLIPVEEMRAGNVSKTFLREIGHVLRTVVVFLKDDNGDNRIEPWQSSQGGEGIGIFFRFKREAYLTLTGNGEAVLSRHRRAGTLSGSKTYLRIDNRGCVDDSHTCIQDASEAAKMLGAAASKGEIDFPIYGVGSEEDQPGAGNWQQIIPAVVVIVVFVLVAMLVIVRKRLRSGGTWFPDDFKWRKTSTGSRGSAQRHGPQGREETPGGMVDGQIMLTISGATTTESSEGDAHEALDWERSQARCQPLNDRPRIQAVRRLSPSSTATTTLPDYPELHSSSHLMLTPPQNSRETEVDDPGQDGMTPLMFAVISCNDRDSDGEECSANAIEELIAHGAKVNAQSDSQGETALHLAARWAQPSAAKKLLEHGANANAEDQSGRTPLHTAVGADAIDVFRILIMHRATNVDAKDNHGITPMMMAARLQVKIDMIEELIEANADVNAADNEGKSALHWASQVNYVDMVKLLLERKANKDMQDNKEQTPLFLACKEGHVETVRVLLDHYANREITDHLDQSPRDKVKENRHRDVLKLLDTYKVVLSPSATSPTVSSPASLANGEMGMVNGYGHPGSKPSAKKKASRSKSAGHQQHAANGDIASHAGEKADKKSSRSRKKRNSTDAPTTASLSPAGSLESPRSFERTSPPFPVYANQASAMVDYQRMPNGMHNGIHQVPRYVEGAAAMNGNAHLSHSLQSINLKTVVPNGEIGSDIGASAIAVSCPPEHQWGNTASHPHSQQNHRLREQQQGMVSQQQQQQQGACASPPSLPPLLQHSMAHDMAAAAVSVSSSPTAQYTLSPTKGYSNQHPHVAHLRHHNHHMPRHPSQYSNGDVHMNRHPKSPVHRSHERSQPLCKQPQPHHNHIIQTQLPNPSVVSIMSDKYPTPPSQHSQGGSPCADNSPHLGVFPEQYLTPSPESPGQWSSSSPHSSAHSDWSGSEGISSPPGPTMNGHIPDSIPIQYSRSAQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK16</accession>
    <name>A0A914AK16_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7</fullName>
            <ecNumber evidence="26">1.1.1.210</ecNumber>
            <ecNumber evidence="15">1.1.1.270</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">17-beta-hydroxysteroid dehydrogenase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">3-keto-steroid reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Dihydrotestosterone oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Estradiol 17-beta-dehydrogenase 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="32 33">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>17beta-estradiol + NADP(+) = estrone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:24618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-dehydro-4alpha-methylzymosterol + NADPH + H(+) = 4alpha-methylzymosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:36379"/>
            <dbReference type="ChEBI" id="CHEBI:1949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136486"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:36380"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16495"/>
            <dbReference type="ChEBI" id="CHEBI:18378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:18411"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>4alpha-methyl-5alpha-cholest-8-en-3-one + NADPH + H(+) = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46832"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87050"/>
            <dbReference type="ChEBI" id="CHEBI:87051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16297"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:18329"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.210"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:16299"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>5alpha-cholest-8-en-3-one + NADPH + H(+) = 5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46852"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87056"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:46853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36836"/>
            <dbReference type="ChEBI" id="CHEBI:47788"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:34789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>zymosterone + NADPH + H(+) = zymosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18252"/>
            <dbReference type="ChEBI" id="CHEBI:52386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:33460"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Binds to the short form of prolactin receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.210" evidence="26"/>
    <dbReference type="EC" id="1.1.1.270" evidence="15"/>
    <dbReference type="RefSeq" id="XP_038063963.1">
        <property type="nucleotide sequence ID" value="XM_038208035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208035.1">
        <property type="protein sequence ID" value="XP_038063963.1"/>
        <property type="gene ID" value="LOC119734503"/>
    </dbReference>
    <dbReference type="GeneID" id="119734503"/>
    <dbReference type="CTD" id="51478"/>
    <dbReference type="OMA" id="WHNIDGY"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047024">
        <property type="term" value="F:5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006703">
        <property type="term" value="P:estrogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000289">
        <property type="entry name" value="Hydroxysteroid 17-beta dehydrogenase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052834">
        <property type="entry name" value="3KSR/17beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44442">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44442:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE_17-BETA-HYDROXYSTEROID DEHYDROGENASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00066807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00071031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00077091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00081545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00083156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00083257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="39265" checksum="E081969D04EB4346" modified="2023-02-22" version="1">MSISFGAKMAEKEEKVVIITGANSGIGLSFADRLLTIDPTVVLCLACRNPSRADTAKKTLLATHPTARIDLVRLDTSDIKGIFETAKNIKRKYSRIDFLYLNAGIMPVTHLNWKHMFKSILTPLQLIDMLTTGEGLLNLQDDTTKDGLKSIFCTNLFGHFVLIQELEDLLCQSQSRIIWTSSSNADKMHFSLQDIQHKHGTQGYSSSKYAMDILNIALNEKYNNRGVFSHLISPGVVATNITSTFFPSWMWSVLYPVFLLVRVFAPRFVIEPSIGAESMVWVYGEDRISVRSDRKYTSYSSAIGNSYIVPEEIEYEPKEPMMLYNQLDKLHKMFQDKYNTSSNTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKU6</accession>
    <name>A0A914AKU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related C3 botulinum toxin substrate 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064347.1">
        <property type="nucleotide sequence ID" value="XM_038208419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208419.1">
        <property type="protein sequence ID" value="XP_038064347.1"/>
        <property type="gene ID" value="LOC119734839"/>
    </dbReference>
    <dbReference type="GeneID" id="119734839"/>
    <dbReference type="OMA" id="CECRAVA"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21456" checksum="75A23668471DCA84" modified="2023-02-22" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLMSPASFENVRAKWNPEVNHHCPNTPIILVGTKLDLRDDKEATEKLKEKRLSPITYTQGLQMCKEINAVKFLECSALTQKGLKTVFDEAIRAVLCPPKQPKKKGPKCSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKY8</accession>
    <name>A0A914AKY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase 36</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Deubiquitinating enzyme 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein scrawny</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin thioesterase 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-specific-processing protease 36</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038064231.1">
        <property type="nucleotide sequence ID" value="XM_038208303.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208303.1">
        <property type="protein sequence ID" value="XP_038064231.1"/>
        <property type="gene ID" value="LOC119734755"/>
    </dbReference>
    <dbReference type="GeneID" id="119734755"/>
    <dbReference type="OMA" id="AEDSGYC"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="133"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="842"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1400"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="878"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1085"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1192"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1231"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1297"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1416"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168346" checksum="2E5FA4AD74E1141E" modified="2023-02-22" version="1">MMTIDQTLKRDLLKTKTPGASTDPIPVEAGVQSGADLDQHLVASSKQVLHKTIDFRPAEKDISFQLQNLRVKYVALNPSQPEAVESGAASSSKHSQMNGQVEVKNDGIPAPKKILYPFEKIALSWQRCQRVGPGLINLGNTCFLNATLQCLTYTPPLTNYLLTHQHKSECREPGFCIMCELCNHVHRTFNHQQNGQAIRPMVILHRLKHFAKHMHVGRQEDAHEFLRLLIEAMQKACIHGLDKLDKYSKETSLVYQIFSGYYRSRVICSVCQNKSDTFDPFLDIGLDIKQAPTVTKALERLIRPEMLDGENLYQCKKCSRKVQAQKRFTIQRSPAVLTLCLKRFDFNRFSMGKINKDLAYSENLNLRPYMSDPKGPPIMYELYAVLKHEGASCNSGHYYCYVKAANQSWYCMNDAFVSQVSLQRVLNQNAYLLFYIRKSNFKSPMNGGESKRDVMHTNNPKPATTISKPQSLFNGPVGVPVPRPSTSTHPQQNAGFKPTVITDDKQKRPLQEQKQEQPQQEARHHLPKMIPLPVQREKLSFQFRPKGSGLGSPNSHGQQPVLVTKKQSPTTAPIKSPVVTGSGDAARQVQSEKSSTTTTTTTTVFSPLRPNPTSPPALGSPKHPLQGLVKPKSRTPQDASNMNGICKKQTGSGLVPYTAEDSNSSSDSDTNYDQVAEALSRNPAGDAGTQTPKITDKSTTKSQDEQKDVSRIENQPDTTPMRPPAAAKTLPSEGLQLSPTHLKKAGLANSINLTTIRKPDSPLKLTITTNGQAQRLKSTTHWRTADSDSQISPSPASDCSLHSNVSTNSTSEWNILEKKDAPQTPEEVKKEAAVFGWNITPSKSVNSEKSASDTDERRTTIKGPKTALKFDNIQDQTPGEKDLKKKLSHSKEETKGSTVTSHTVVESSSVPKESGDKVTDNEDLQVQGTSVDLKPQIDSELLGTSLKSENSPERGTSEECGEVATAKKKKKKKKQHLSPTDESFAELDKSELLLSESNTDKEPAEGTSLQMSSRETGNASDCLLETPKKHKKKKKKKKKKEKLEEEEEVELVEEWVERVVEPQIHDDRVPLLSDSKTHTDKHKKEHDSHDKHKSTRNLDSHSDEDEASHKHSTSYKKHKEKHSLIRRTIEKNIKLHRNRHSSSDDSRETSSRHNGHRRDSHSDSHHKRTFSHKRTHGNHESSLEHSKHYKESRKTHSSDDHSGSDYPAKIRLLEDDSPVDSHREKKKRKHSDSYRHRHSSDSKHSKSHKEHRIRDSDKDGKYSEKSPRLNGDDDSNSHRKEKKKKRKHRDEDEVEEALLHRGREDEDYKPEKKKKKKKKDRPLDEEEESTRDVEDAVTKHKHEDKVPVQQWDHHIQDGHRKHSDDGNKSKTHATWDGSHSASGVMEELGKASLKSYGPAIKSWDGGRSVLDNEVEQDSRKDRQRDPYEEDFDRGKVKKVKKHHDDSRRKMFSGRHNMFQSVQNMRNKVSKEHHGYSRFSHQSHEERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL41</accession>
    <name>A0A914AL41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Folate receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064149.1">
        <property type="nucleotide sequence ID" value="XM_038208221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208221.1">
        <property type="protein sequence ID" value="XP_038064149.1"/>
        <property type="gene ID" value="LOC119734691"/>
    </dbReference>
    <dbReference type="GeneID" id="119734691"/>
    <dbReference type="OMA" id="NSCCMQE"/>
    <dbReference type="OrthoDB" id="5982417at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF28">
        <property type="entry name" value="COILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037976442" description="Folate receptor-like domain-containing protein" evidence="5">
        <location>
            <begin position="36"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="6">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="220" mass="24643" checksum="87697B470514009C" modified="2023-02-22" version="1">MAARHLNGIHTASLLPCLVACVAGFLSIALAPATSQEITDIKVPSTELIVPEDTEKPYCTFFNNRKPEFQPNLKNCTWYQDNCCCRQVEIEVAFGKVKPLQGATLPCQKYINYLICYICAPTQYKFYLWQRLTVCEEFCDLIFDRCKDAILKGSAIGELYKNGTNFCKSRRFEVAPYSSGKCFYFNETMDTSSTGSIVVSPAVSSLVWAGLMVLTVLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMI7</accession>
    <name>A0A914AMI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064731.1">
        <property type="nucleotide sequence ID" value="XM_038208803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208803.1">
        <property type="protein sequence ID" value="XP_038064731.1"/>
        <property type="gene ID" value="LOC119735102"/>
    </dbReference>
    <dbReference type="GeneID" id="119735102"/>
    <dbReference type="OrthoDB" id="10417290at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="201" mass="22257" checksum="D58C8979F2E41199" modified="2023-02-22" version="1">MCSAMIKAAPGDDLTALRDKAFAAFRTECRGKQGNLDDTKSCSFFLESSNPAAATFILQPLRAPFRLDFEVKTLRSANIVLAEDETEVSVFAWITIGGWSAQMSVIRACFVHDSPECQQLLGGRSQHIEGDIVNGTESRPFWIEFKHGVVTVGKGGQEEAFLEWDAAAYHRRNISTPVYLGISAWSYVGLSADWVFYQFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMQ8</accession>
    <name>A0A914AMQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064716.1">
        <property type="nucleotide sequence ID" value="XM_038208788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064717.1">
        <property type="nucleotide sequence ID" value="XM_038208789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064718.1">
        <property type="nucleotide sequence ID" value="XM_038208790.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064719.1">
        <property type="nucleotide sequence ID" value="XM_038208791.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208788.1">
        <property type="protein sequence ID" value="XP_038064716.1"/>
        <property type="gene ID" value="LOC119735091"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208789.1">
        <property type="protein sequence ID" value="XP_038064717.1"/>
        <property type="gene ID" value="LOC119735091"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208790.1">
        <property type="protein sequence ID" value="XP_038064718.1"/>
        <property type="gene ID" value="LOC119735091"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208791.1">
        <property type="protein sequence ID" value="XP_038064719.1"/>
        <property type="gene ID" value="LOC119735091"/>
    </dbReference>
    <dbReference type="GeneID" id="119735091"/>
    <dbReference type="OMA" id="TGHWNAP"/>
    <dbReference type="OrthoDB" id="10072637at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12435">
        <property type="entry name" value="RRM_GW182_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052068">
        <property type="entry name" value="GW182_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033503">
        <property type="entry name" value="GW182_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020:SF25">
        <property type="entry name" value="PROTEIN GAWKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13020">
        <property type="entry name" value="TRINUCLEOTIDE REPEAT-CONTAINING GENE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="868"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1573" mass="164025" checksum="F99B25CC5057F811" modified="2023-02-22" version="1">MDQTSAKQRIVVDEHDMEAWPAITRGENSRPAAPSENELKVASSAGTINTIAAPTNMPASGHTQAPPSEPGHASMAATTASGAKSIWNTGWGSITTTAGNSVWGTSTPSLAGSGSAEVENSKDPRSGWTGGNGSKSVEESNGMDTQPPAPQQGQVSDRMQTESPRPSSTVPASTSGWGPAKEQIIGANNSATSANGSSWAAGSSTTSSNNQLDLTNTAPWSSSNTSAGGPSGWNTAPPKTPTSGWGDMPNTAGSAAPAAGWGAVPTQSSNSGWGGKPNSSQQTNSSEAAAVPGWGDSTTPGSQWRRPGQTPTSAGPSGWGTLPSPSPATGPATGHVGPATGHAGPATTGWGSNSAAIPNDGPDSRPNRQPPTPSGWGGGDNRRNGGNSSGWGPPSGNSWEPGNRSDPKFSSMETNAEGWGKKPINQDTQWEGGAQQVPKTLDNGTAAWGGNQGTPAAPGWGPNPPPPSAWGKPRMPSEAPQVVTPPAPPPAQSAWGGDRKPAWGATPGRNDGNVGIPGPGIRGGSGIDGNMGMRGMVGNNAVGGSSGIGMSGSSVMGSGSSQWRQPPGPMERRESTGQSRPSGWGNPMGMPPGSNTHGQSDSSSWGTWSNEEANPPMEGPPPPRMPEKLSGWSDISDIPTTIIPTGWGGPSTQPNRKMPVDDGTFVWGNSGEHNARIEAQNRRNIVRLASLVEEEEHSTMQTPPPGTPGEAEDGTAVPPSPVTTNAPEGSTIQAPKPEGGTTTQAGWGEASQDQKAQGWGSAPKTSEEGQGTGWNRNGGAKPASSGGKWDEPWGGSSTTGGSTQDKDSMQAGWNEGPGGNGNAAGHWGEDDWETKSQSSESSVSSSNWMKGRNNKQVRGTNGMGSIGQKESNHWISKLKRLMDQGYRQEEAEMALRKHNMNFDSALMELRQMSDGKSGDLDAHLRQVNRDMGSLMLGGDNHLPDGPKPFGMGEGPPPPPSPMSNPGMMNNPMGPKPGFSNVRGGFPPNQQQRFGNMQQQQPQGFAPPFAPPNQPLRGPFNPQMMQQQQQQQQQAQNFLQMAVQAGLINQSLLQQPLSNQQVMQVLQSIPQQLQQLLQAQQQQNASGKMPNIRQQEVMQRLIASQRGMPRPPFPPRGKLHSDSEVFPNNEGSGPGNNADFGVKEPQQSRLSQFFAQRQSLSSAVGKPTSDLFPSSGRNDSMASISDVSSRSDGWSRSNSPTQSDSLPHSADSTFSDSGWSFPHSNSEIDLLEFKPGVPWKPRTKDVANDPHATPGSVNNDLLNSSSLTVGGNTRSNRNDRSSRDDISGILIKPMKPPPPNSNWTGGNSGNPNFKKSSWNYQDQGSAFSQPTSAPNWNVPSTNQRPPRPPPGLDQPRNAGWPVSSSQNAPGGRTWDRSHSTSGAWPGSEGATNWLVLRNLTPQIDGSTLRLLCHQHGPLEHFHMNLSQGTAIIAYKTRDEAVKAQRSLNTCVLSNTTIIADFATSADIARSRDRSQSQSGGSGKFSSTGSSSGSNPGSSLSGIPSFGIKEEAPSGGSSGSSGGQWNGAGTQSLWSTNTSATSTPWSGGETETTAGAGVPSSLSFLPGDLLGEGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN17</accession>
    <name>A0A914AN17_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064819.1">
        <property type="nucleotide sequence ID" value="XM_038208891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208891.1">
        <property type="protein sequence ID" value="XP_038064819.1"/>
        <property type="gene ID" value="LOC119735185"/>
    </dbReference>
    <dbReference type="GeneID" id="119735185"/>
    <dbReference type="OMA" id="HDIANIT"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037240792" evidence="7">
        <location>
            <begin position="24"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="299"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="409"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="520"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="622"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="807" mass="87581" checksum="49B8136AA560407A" modified="2023-02-22" version="1">MASKTVVLLIAFAVAWFPHEALGRLCTFESGICDWTQSTADNYDWSRHRGSTSTSYTGPYYDKTYRNSNGYYLYLESSSGWQGSNAVLLSPIFLHKNGRQTVCVHFWYNMYGSYMGTLKVKRIPTSGNLGQETVLRSWTGQQTDSRTWLEMELCTSDSTSNFRLAFEAVRGNGGRSDMAIDDVEIIVLPATITLSDPTGSLPSTDAVSYLVQGVESQFTCRVTDIDPGASFTWSLGGRELTFARSENGTVSGGLITSTSSLTLSPTWSNHGELLQCSASNKHNHPGLNITATLDIKVPPTVITLYESTDNITATNGTSFLIEGVEREFICEVPGARPAASITWILGSRNITANESTDVVGADGLTTSMSTVRLSPTWNHHGELLQCSASNIDDWPAVNASVTLDVKVLPTSSAMSLYDGTGTRLGQTLDVDQGASSNIRCEVQGTRPAVTFRWILNGTLQQTTHPHPVEADVGLVNSSDTWTFTPSRANHRQEVICAAITAETQEPIPEKAVTLDVIGPPDKPVVTGDKTMEEGLATALTCRADNGFPDDWSLHWSYGHVHDIANITTEPLPSGNRFMFTGVINITPKRNDNGKTMTCTARIKSCTQHHTGAFGPLNVQFCPRRVHITDCALTAVPGINASFSCFSESSNPESDLMWLRNDEEQVNPAESEITSGDYGGRVTTLNFTTGVMTEEDDGAVYRCCAKGNALCPRVCDACLMNVAYVKSNDPGLSAGVGITTIVSVVSIVVIVAGVVYYRRSTTKRRQECKPAKHTGRETGNSDEERYAAVQDEKNTGICMQMVTSAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APK1</accession>
    <name>A0A914APK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 45B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065369.1">
        <property type="nucleotide sequence ID" value="XM_038209441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209441.1">
        <property type="protein sequence ID" value="XP_038065369.1"/>
        <property type="gene ID" value="LOC119735645"/>
    </dbReference>
    <dbReference type="GeneID" id="119735645"/>
    <dbReference type="OMA" id="WYQYLEL"/>
    <dbReference type="OrthoDB" id="551896at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33469" checksum="FFCB3E7830521B4A" modified="2023-02-22" version="1">MGTFAGHALPGSFFILFSIWWMIQYAYEQIALDNGRQQPRGRIMRTLHRLPIEGITVVLAGFIGFIAENMYPSPKWGIFDKDGNFAYTHVWQHCEMYTFFALYGLADILSKTCMPKAEKYTKILGSLAFFVEGLLFHFHTVGRTTIDTHLHNLLVYAIAACVVLTLAEAFYPKEGRFRALRCVAVLLQGTWFFQVGTVLYWPPSGKPWDDEDMANLMFLTEAFAWHLLVDILLMLMVYGISCLVLKKTGLTAVHYRKMNGIADGEDIEFGTRVLLDNGAPNNLDSDNELFDSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASE7</accession>
    <name>A0A914ASE7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066692.1">
        <property type="nucleotide sequence ID" value="XM_038210764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASE7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210764.1">
        <property type="protein sequence ID" value="XP_038066692.1"/>
        <property type="gene ID" value="LOC119736752"/>
    </dbReference>
    <dbReference type="GeneID" id="119736752"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="26526" checksum="A5F9DD732295EC68" modified="2023-02-22" version="1">MYWYFGSTSDASLLISNFFGRVAPQNGIPEGVYDIDNDFSLVIENVTASNEGTYYFQVKPRSKEVESGSVEVCDKVSPSRPYPTVIGCNQDHDADTCEVRVRHDSTVHYLTCVMEQVKPAVQLRWIHLFLGGQTELSAYRTVRPVVLPAYTGSSLRNNTSSTSASVHLTRVDDEEVYECEAVGVAVGNSTRTRVYLTKTHPTTATHPTTATHPTTATHPTTVTHDTTYNEVQFSNNPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AST5</accession>
    <name>A0A914AST5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066534.1">
        <property type="nucleotide sequence ID" value="XM_038210606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AST5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210606.1">
        <property type="protein sequence ID" value="XP_038066534.1"/>
        <property type="gene ID" value="LOC119736590"/>
    </dbReference>
    <dbReference type="GeneID" id="119736590"/>
    <dbReference type="OMA" id="WICHIIT"/>
    <dbReference type="OrthoDB" id="6085995at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="39641" checksum="EBC4F5F5CB67D323" modified="2023-02-22" version="1">MSSMNETRLSTNDSEHPGNEYKWICHIITTEGVIGVLGNLLVCFVILRVKFLHNMTNYLLVNLAVADMLLCLQAFLLYFFAFSKCAIVHYVPAGSVERQIFCRLLASDFLSWALSYVSAYSLCLVTLERYVAIVHPLKYQRKVTASRIARLVALIWVVPFLYSLPFVFTIKPSDDPDQACSEIQYPHQAFPIVIGVLSFLMDYLLPITLMSLAYYKIQVTLKRQAKALNLQHARAAAYDLVIARQRLVSMLTIVLGALIILWTPAYLAITICLQASRGRSHMTFCDSVTFQHIRGVCSSLFYINSIVNPVIYEFKYKKFRQGFKVAFCGCFQKKLSNRVENLTPLQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASW0</accession>
    <name>A0A914ASW0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066748.1">
        <property type="nucleotide sequence ID" value="XM_038210820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210820.1">
        <property type="protein sequence ID" value="XP_038066748.1"/>
        <property type="gene ID" value="LOC119736776"/>
    </dbReference>
    <dbReference type="GeneID" id="119736776"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="235" mass="26244" checksum="78204DD27A172DEB" modified="2023-02-22" version="1">MTILSIVGLFVTGFFNAQDDDGNGLTSGLSNLPTKQNSVLKVFFRLWSLIIAYSVGYFVSVTMYLCLVGVVALTWFSYRVAGQPFTDARTVVMQDIKATLELQSALHNVKRKTPLTWQGRLRSAKHGAKRRFVDTTVLKTVVEEKSLQLSGKRASGISVLESVVSTSKKKSNFLFSIIQLPEDILKSISFAIRIHKIPNSQVGKFVEDVANNLECLNEKEMKIQIDRLREKVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUV8</accession>
    <name>A0A914AUV8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067870.1">
        <property type="nucleotide sequence ID" value="XM_038211942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067871.1">
        <property type="nucleotide sequence ID" value="XM_038211943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211942.1">
        <property type="protein sequence ID" value="XP_038067870.1"/>
        <property type="gene ID" value="LOC119737519"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211943.1">
        <property type="protein sequence ID" value="XP_038067871.1"/>
        <property type="gene ID" value="LOC119737519"/>
    </dbReference>
    <dbReference type="GeneID" id="119737519"/>
    <dbReference type="OMA" id="VPEYAYI"/>
    <dbReference type="OrthoDB" id="5988333at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="367" mass="40315" checksum="0A63349CE7BD291A" modified="2023-02-22" version="1">MDSTQETDFLELMAGPSDTVDDLNTQQVTGGNQHVSSVKPKEKTRKTKTVSRQEFVDVTEKLAVMAEAIENIQTAILSPPAAKRPRLASESDSDNTSASKAIDELLKESVLDSENTGQDDQLLNNFEQLYTEDAPTAAAVNEKLAKVIDKMVRNKLPEDKAAEKLKALQRPTNVKNLECTRVNPEVWSSLKPKTRSQDIKLQKVQQALMKGVVPIVGVINSLMTRLNGSAAGTDNLDVKGEITKLLDAIAVIGHANHELNMRRRELIKPDLNKQFSGLCSSHVPVTGLLFGDNLPQQCKDIQQTNKIGQKVGFSTGSRGTDNKGSLHRGNLASAGRRRGSYLNYQRYSKHQGSRWNHKPQPSAGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWP1</accession>
    <name>A0A914AWP1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068530.1">
        <property type="nucleotide sequence ID" value="XM_038212602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068531.1">
        <property type="nucleotide sequence ID" value="XM_038212603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWP1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212602.1">
        <property type="protein sequence ID" value="XP_038068530.1"/>
        <property type="gene ID" value="LOC119737930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212603.1">
        <property type="protein sequence ID" value="XP_038068531.1"/>
        <property type="gene ID" value="LOC119737930"/>
    </dbReference>
    <dbReference type="GeneID" id="119737930"/>
    <dbReference type="OMA" id="HIRRCCA"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF1">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="391"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="507" mass="57289" checksum="2E335EA0C526D793" modified="2023-02-22" version="1">MDQGTVIHLQGDMGAAVEIIVQEHPVGGAFVEEGSTGGATDVERQVQDGNSDAIPVFLSQNAEAEGGQEDGHGDLDQIQIPISNTDHKSALVSDTLFDVAMSERFGYVYSLDRAEKVRRNFEVRTNTSYVAVSNVRPNFGQTELSRENHRIYWEEPQQDTPIKSTSRIKFDGVPFILLAKRVLDCQHGRAWNRRRDKEKPERKRRKKQCTPATRKLGCLANITMRELMCFPEFKIVENSEYKRKFASKQLRMALKKGGVRGEKRIYIDLPDVSSHNHPIDQNTQVTHQALDERVMKKLQELVAAGVLDIEEMRMHLQNYVQNEICFGQPSIPLSNRRFFPSKFTIRTQVHRCCTPQTHTHEETSEFKIRGQSHQSVNMAELPVNAELAKNIGTEFCEQYYNTFDTNRAGLAPLYTDVSVMSFEGDLKIGANSIIAKLMALPFKAVKHVATAVDCQPTVDNSILISVLGQVKTDDDPPKSFHQSFLLKSGGGNYYVLNDIFRLSLHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYE9</accession>
    <name>A0A914AYE9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069175.1">
        <property type="nucleotide sequence ID" value="XM_038213247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213247.1">
        <property type="protein sequence ID" value="XP_038069175.1"/>
        <property type="gene ID" value="LOC119738373"/>
    </dbReference>
    <dbReference type="GeneID" id="119738373"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF421">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="176" mass="19578" checksum="C742CE415091B571" modified="2023-02-22" version="1">MNSTGTNEDLSTFNASTTPVTQDRIEYNFIRCILLIITTTLLLTLNPLCLVVLRHVRSIQETTKIFLRSMTVADLGIGLFRALPMTVLAISETEHIGEAFCKVLSFAEGILFYSPQMSLLMLTVDRYISVVHALRYPSLFVDVQSRMNCTDVMLACIADVLYVADVLYVAHAGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B177</accession>
    <name>A0A914B177_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069663.1">
        <property type="nucleotide sequence ID" value="XM_038213735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B177"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213735.1">
        <property type="protein sequence ID" value="XP_038069663.1"/>
        <property type="gene ID" value="LOC119738776"/>
    </dbReference>
    <dbReference type="GeneID" id="119738776"/>
    <dbReference type="OMA" id="HYAYARS"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000024">
        <property type="entry name" value="Putative phosphoribosyl pyrophosphate synthase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000036">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="39345" checksum="789F369C69CC286F" modified="2023-02-22" version="1">MNTMSRGGLLVISGNSHPELSRLVAARLGVELGNVDVYLQDNKETNVDINESVRGKDVFVIQTGAKDVNNAIMEMLIMTYACKTSSANSIVGVIPYLPYSKQSQMRKRGSIVAKLLATMLCKSGMDHIITMDLHHKEIQGFFDVPVDNLRASPFLLQYIQEHIPDWRNAVIVARNPSSAQRATSFAERLRLGLAVIHGEQKVPEQDKIDGRHSPPTVRTFSGHSLDMLPLFTPKEKPPIDVVGDVGGRIAIIVDDMIDEAESFVAAADVLKERGAYKIYVMATHGLLSADAPKKIEESCIDEVVVTNTLQHELQKLQTKKIRTVDISPALSEAVRRIFHRESMSYLFRNISKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1W6</accession>
    <name>A0A914B1W6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069491.1">
        <property type="nucleotide sequence ID" value="XM_038213563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213563.1">
        <property type="protein sequence ID" value="XP_038069491.1"/>
        <property type="gene ID" value="LOC119738647"/>
    </dbReference>
    <dbReference type="GeneID" id="119738647"/>
    <dbReference type="OrthoDB" id="8066719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="139"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="273" mass="27990" checksum="354F91A4601A2834" modified="2023-02-22" version="1">PVASDGDGPASQAGQTCCQETAAIVGILQGSKGDAGQKGEPGDDGRGLPGKMGPRGFVGPTGETGVKGQKGDIGPRGQRGARGVKGQLGLQGRTGFAGEPGLIGPIGPQGDTGPKGSVGQTGQTGVKGQKGEPGEAPDDSNQRVAFTVVRTSNSDTSTSHDNRLPFQATETLLPGTSFDLETGAFTCGVPGTYVFMFSVCKSSSSSHLYVYLRKNGVVVVGGNSNDSSHYEQVSGSAVVVLQRGDTMYLTMHGRANSYSDHRTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2M2</accession>
    <name>A0A914B2M2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069751.1">
        <property type="nucleotide sequence ID" value="XM_038213823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2M2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213823.1">
        <property type="protein sequence ID" value="XP_038069751.1"/>
        <property type="gene ID" value="LOC119738853"/>
    </dbReference>
    <dbReference type="GeneID" id="119738853"/>
    <dbReference type="OMA" id="MFYYKTD"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34923" checksum="774939ACB93C631F" modified="2023-02-22" version="1">MAAPMVRQILTQSARNSLVFTSFRNRFSTAQCHLQQNETEELDKNKYFDKYADKIKEIRSSDPEKFQSKLQDLKESKKEMKWRDEQESLRPAKSDTSQPRLLKTSQHTSSQKSLDSILKIDLIQDLPKEEIQKIWTQYHAKKDCISAVIPGITYDKICQTARENPLFLYPLPKENGYEFFFAQFDNNHSCYFTSLINYQAFQENSPILLSMKHYTELQKEKGIVLMRGEMDTNVMSVQNAQFLANQLQLYYATDNPDRLKLLRIFNHRQDEFRHMDVIAQLEKSTFELPTTSTDGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B380</accession>
    <name>A0A914B380_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">F-box and leucine-rich repeat protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069955.1">
        <property type="nucleotide sequence ID" value="XM_038214027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069956.1">
        <property type="nucleotide sequence ID" value="XM_038214028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B380"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214027.1">
        <property type="protein sequence ID" value="XP_038069955.1"/>
        <property type="gene ID" value="LOC119739192"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214028.1">
        <property type="protein sequence ID" value="XP_038069956.1"/>
        <property type="gene ID" value="LOC119739192"/>
    </dbReference>
    <dbReference type="GeneID" id="119739192"/>
    <dbReference type="OMA" id="FHFRFYG"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22104">
        <property type="entry name" value="F-box_FBXO33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000005">
        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000260">
        <property type="entry name" value="F-box/LRR-repeat protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00070268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00077971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="408" mass="47397" checksum="7B94F61C30F7C6EF" modified="2023-02-22" version="1">MDSEKRWSDLPDHIVINILSYLPLTDRCSASLTCKNWYECFDDPTLWRRFTFHFKNDQDTGQLQCLARHGRQLRVVKIYLNQQELVNRQNACEVLTGLARCSDRRLEELSVTFTTENPLFFQGLEFLSSLAELFGPPDPGTKMVSTLTKVDLSGLSVTYRDNLLYLLADNHPNLQVLNLQNTSLMCFINPECMHIVVKKCPKINSLSMHYRSASEELFAELSDQTRTPLNYLSLACNREEKYHKVIPADSWKSLVRRHKHLRVCMKFDHTIERHRILTILDPQIPLVELHMRTMTELHDEVSIVALYYHKTLEYLAIVTKGSDELKRVLLHLVEQSPRLHTLHCYCALDEVTIDRIRALRPQLKKYTLKTAEEFDLLVPTLTDLKECVESLSSKWLASGRARYRAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3U9</accession>
    <name>A0A914B3U9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070479.1">
        <property type="nucleotide sequence ID" value="XM_038214551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3U9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214551.1">
        <property type="protein sequence ID" value="XP_038070479.1"/>
        <property type="gene ID" value="LOC119739559"/>
    </dbReference>
    <dbReference type="GeneID" id="119739559"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="277" mass="31329" checksum="62FAD9BC70E6FF1A" modified="2023-02-22" version="1">KVRGQNKGGTKPQQPIGFLGEVMLKNGRELGEDSTFGTAMVEMGESLRQQVKGAFDLIVRQNFLDPLDHLKNKDLTEINHHRKKLQGRRLDFDYKKKKQAKGSTIPEEEIQFAEEKFHESQELAENGMRNLLESDVEQVLQLQALAEAQLEYHKQSAEVLESLLSTLNERVEEAGSRPKSERKPRSTFNSYSTKRDSSDGDDTDAYPSTVDYNAPVPVTATKERCKALYDFEAENEGELGFQEGDIISIVSKIDENWIDGELNGHTGYFPANYVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6V9</accession>
    <name>A0A914B6V9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071941.1">
        <property type="nucleotide sequence ID" value="XM_038216013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6V9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216013.1">
        <property type="protein sequence ID" value="XP_038071941.1"/>
        <property type="gene ID" value="LOC119740649"/>
    </dbReference>
    <dbReference type="GeneID" id="119740649"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="42182" checksum="C13FC00EE8782CD3" modified="2023-02-22" version="1">MDVTTSTVVTEGVTLDPTESSTFEFSDYTQRVIVATMFLVISLLGIFGNTLVILAVLLSNKVRTATNAFVVNLSVADFLTSLVIPWNAVALLGREGLPVGVWVCSITAAVQYASVGCSIFSLVAIALNRFLLITRPATTYHKVYTPKKIIILLIAIWLVPLSISIVPSFIIIEFTYNDKLHMCMPISKASTGPATFTYNIIIGGILYPILLINIIVCYVLIWRHLKRHSRRMAMVHKVASDLTPSSIPTTTTVTIPLTHMTSNDRIHSPATLSSVPAINSQVRRRQNEITKNMFYVVCAFMLCITPFAVVGTTKHGPTLPYFFALFFANSCVNPMIYATKHRDFKTIFGCILRRQWAAIPEPSGVLKFVQRNKRCGATVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B700</accession>
    <name>A0A914B700_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071734.1">
        <property type="nucleotide sequence ID" value="XM_038215806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B700"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215806.1">
        <property type="protein sequence ID" value="XP_038071734.1"/>
        <property type="gene ID" value="LOC119740482"/>
    </dbReference>
    <dbReference type="GeneID" id="119740482"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036927193" description="Sugar phosphate transporter domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="8">
        <location>
            <begin position="627"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="131021" checksum="21EF907C6F7392D3" modified="2023-02-22" version="1">MASVVLFVAVWWIANMVATIASKKAVSGIKPDATDSLTTWTGTAALKDLRWIELTMLQHLFGALLANTWLLVVRRKSVFPKESLNPKHMLLAVTGNLVGNLATNASFAAVSSSLTQVIKSCEPIFTFVFALLFYKNSGNLTRNVLFSIIPMVVGTCLFISGEVSFNIWGLGAAVISNIAFPIRNIYLKKLGQSWDDPLQKIAVVSNLNVLILLPFAIMSMSSLGKLPRLESCTSATFHFIYNAASIMVLQAFSPVEHAMLNLSKRMFVILANMIVFSTPFTFWTVTGLLIIFIGHYNNQGGRIFKQIMKMRRCFSPAIIVFGISSFCWFVGFFRSDALMNQLQMQLTQYQPREVITTAWVYERPIPYNVVENIEAFLDRNPGMTVKVFCGTSQCMKAVQGTHNPEITGEFLVLPDIFKNTPLELWLARHPIHKILTGVDFEDHVYEAVRLALLWHHGGIHFDPSIKHGEFTIPGHQEAWVSIGTNLTQTKTHGVLSVSRFPVHSAFIANLTKAFCREYSRNITNGNPRSLQKFDFQGAVSDMFNQSCMSGDHCPTHIETDLERISVVDARRRHFGTLSYASRASRSKRANLGDEVQGFPGIQFLPFVDRFVDRDNFNKAKRDNHIRMFFNAWYGDKGMTWPPPRNIDPIMLSVHISPRIRPMFTKYIKYLQSKEPIGCRDSDTLKFLRQKDVDAFLSGCLTLLIQTPNIENKRSGQIVLADVHKAFAALLPPDIERIAIRVTHIGVGGGKSTIKERFQAAYDLIQNYSEARVVITQRIHCALPCVAMGTPVIFINSKHMPGGGAERGLKVSSRVTGLTPLFHTVDTFKMSQESIAQWLRDFNWRNPPPNPDVSMRMRLRATEWNVIRQDPVLYDSARKFGLLPLSPPATNTPNQLVFHLILNRTRNLTSLDWPKWRTIESIFYHYPHARIIIHSDSLQTGQFDVLIESGYTIEVHSLSASIGNNIMKNKIDIKHFRRFGSRLNEKDFAKLAVLFQWGGVYIDADVVLLRQLNLSLINTLVWGSKEQNSFDLSFMRFERGHPFLETILKASEWQASPKDRHLSAFEALLFHTWSNYFKNSVKVLAQRDFFKQFSAQNARDCLQSTSGPIFESNMKQIRREVVFAKMKGSLTNLSKLQNGTICKYLFNSFCVLCNNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8B7</accession>
    <name>A0A914B8B7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072229.1">
        <property type="nucleotide sequence ID" value="XM_038216301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8B7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216301.1">
        <property type="protein sequence ID" value="XP_038072229.1"/>
        <property type="gene ID" value="LOC119740852"/>
    </dbReference>
    <dbReference type="GeneID" id="119740852"/>
    <dbReference type="OMA" id="DWAPPKD"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000003">
        <property type="entry name" value="39S ribosomal protein L45, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="9">
        <location>
            <begin position="153"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="37836" checksum="518E3F9668F5CB82" modified="2023-02-22" version="1">MRSCASRHAKISARTTYVNTHEHDGCVRRIGNARLVQQVACLSSCWLIPVRHRTRINPPKATKKGRLLLKDQERLKLKEEYKQDPQKMLIETLKKSGIKPCPSFTERAVTITCTGEIFEPYVPPEGDGKAMSLTPEGAKQRLERVKNIGVTQLNQRKIRQFEPEFTASEFAWKAQKIFIDAHNALQDFDKNILHQLATEKAYPEMTKGFRFKTIRWKFLESIEKPRVVHIRTTDMINKGNLYGQVTVRFHSKQTLAIYDRFGRIMLGSEDIPKDVLDYVVFEKHLSGLYGSWRIHGKIIPDWASSLEPVIQTMIMQGQGGETDIAVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9E8</accession>
    <name>A0A914B9E8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072624.1">
        <property type="nucleotide sequence ID" value="XM_038216696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9E8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216696.1">
        <property type="protein sequence ID" value="XP_038072624.1"/>
        <property type="gene ID" value="LOC119741058"/>
    </dbReference>
    <dbReference type="GeneID" id="119741058"/>
    <dbReference type="OMA" id="DCNEGDY"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869617" description="VPS10 domain-containing protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="9">
        <location>
            <begin position="155"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="867" mass="97208" checksum="62B95DE18E05D6CD" modified="2023-02-22" version="1">MANRSSILSYVSFSVFMLLFANLTYSESAKEMNLHVRRNHINMNMKKSTFTTSIDGMYSQNDFSSTRNMTNVKHKRHVRNRLQVKSKRRQVRDVASNPVDVATQDSECRIPDQQMAALSNSKHTSFYMFNDSNFNLAMIWTGTDGKELMALSTMEYTFFSEQSQLWISKDFGRSFVNINHRIRGAVIKAKDGVFKSSIDPQRVILVSYMEDQDMSQTRVYVTLNGGETFDESILPFYLDGAIVFHSTATNMLLAHSPYQQFKLWVSDDFGIHWRDVQSNVMSYSWGTKEMEPGALFVLVSSGTDKDKTGSGTRKLLRSTDYGKTFLAIKMNVYSFGVQGKFVFAAVDGGKGDNGRILYVSKDDGKTWSPTQLPVVTSDRFFSVLDMNEGMLFMHVDDEGDTGSGTLYTSDADGIVFSVSLKKHLFAEGSATTDFYRVASMRGVYMASQVGDDLSIHTNITFDRGGIWHPVKAPKGSKCKNSATSCSLQIHNRYSQIKGVNAPSSPLSQSSAVGLILAHGNVADALETHPPDVFISNDGGYNWTKALSGPHHYTVTNHGGLLLAISAEQDVTNTIKFSYDEGHCWNEYKFCDEPFSITGLLPEPSTNSLNVSIWGFGSEDRRWRIVTIDFSAVLKDECTEKDFDEWVPHLSNERRGCLLGLNETFERVKPDSLCRLNYAHEPKAKQSNPCSCTKDDYECDFGFSRKGESKECKVSADVDPSHLDICINGNEEKINTWGYRKIPGDMCVNGFQPVRSMDTLQQQCTSGLESNLSVEQLDGHQVKTWTIVMILLAVAFFSGILVFLLYRHNKLPCTRPSLASYRYSQLSDGDNLDKMIDLESHPTYHDSSDEVSTAYSIVQNIVGVFKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9M2</accession>
    <name>A0A914B9M2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072699.1">
        <property type="nucleotide sequence ID" value="XM_038216771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9M2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216771.1">
        <property type="protein sequence ID" value="XP_038072699.1"/>
        <property type="gene ID" value="LOC119741100"/>
    </dbReference>
    <dbReference type="GeneID" id="119741100"/>
    <dbReference type="OMA" id="RWVEETH"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF4">
        <property type="entry name" value="ZINC TRANSPORTER ZIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054161" evidence="8">
        <location>
            <begin position="18"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="617" mass="67236" checksum="74BFDEB19A9C270C" modified="2023-02-22" version="1">MASFVSLACCLKACVLCLMCTAMVSECTKLLGKELQNSRPGFKVITEGKSVGADAAIVTSQQLDTKDISPEDHLSCRQFFKREICDECFIENNSVSSNAQLGGTASRRDGPVAPATINELARVGSVLVSKLQQGTCALGRSTVGRVRRSVVVGDIDASLFVEAIYEKYGTSGVINEDQFDSLLQDLGVGKLMATTTAQSPTNHSDSDDDHTAIKQCFLADDLVAIFNASKGIPEERFASICPSLIQQITQGCVAPVTPPTELDLKMYAWATIAVASITILSMLAMIAVPTHGSRFYAAVMQLFVALAVSSLSGDALLHLLPEALGIHGMPKTEGQPNHILITLTVILAVYFFFVFERLMSLCLKGKPHGHGHVHSRPRRETFIEDDECGTHLDAMKEVGEKYHHESTKTDENHDGKQDDQDTISNKEVEETTTKDMKLDKDKEAASELPKSQQTIFGLNMLSVMVLIGDVVHNITDGITIGVSFVNGPFAGISTTIAVFFHEVPHEIGDFAVLLRSGVSFRKAMLCSLISNMIGFAGLYAGLLLGSENVIQRWIFAATAGMFLYIALVSLVPEMNQQAEEAERNPWRVFLRHNIGLLLGWTVMLALGVYEQYTEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAF3</accession>
    <name>A0A914BAF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072933.1">
        <property type="nucleotide sequence ID" value="XM_038217005.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073066.1">
        <property type="nucleotide sequence ID" value="XM_038217138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217005.1">
        <property type="protein sequence ID" value="XP_038072933.1"/>
        <property type="gene ID" value="LOC119741251"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217138.1">
        <property type="protein sequence ID" value="XP_038073066.1"/>
        <property type="gene ID" value="LOC119741386"/>
    </dbReference>
    <dbReference type="GeneID" id="119741251"/>
    <dbReference type="GeneID" id="119741386"/>
    <dbReference type="OMA" id="NDIFACL"/>
    <dbReference type="OrthoDB" id="10253415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF157">
        <property type="entry name" value="DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="140" mass="16031" checksum="9FAB2A232A0C4547" modified="2023-02-22" version="1">MEEAINNVMTECGVPYNLKPEQIQIIRSVLERRKNVFGLLPTGFGKSDCYGWLSSIMDKIEPDVEHITLVISPLRSLMLDQVERWSSRGVTCAAIMRADEIDDATKEEITEGKFQLEFACACLLQQHSRRDEHTCIRPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBE3</accession>
    <name>A0A914BBE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="15">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="15"/>
    <dbReference type="RefSeq" id="XP_038073160.1">
        <property type="nucleotide sequence ID" value="XM_038217232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217232.1">
        <property type="protein sequence ID" value="XP_038073160.1"/>
        <property type="gene ID" value="LOC119741474"/>
    </dbReference>
    <dbReference type="GeneID" id="119741474"/>
    <dbReference type="CTD" id="54901"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000005">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="18">
        <location>
            <begin position="81"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="217"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="17">
        <location>
            <begin position="448"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="576" mass="65083" checksum="593C45A1931ABF4C" modified="2023-02-22" version="1">MPACEQQRVDDIEDIIGSNDVTPVERYGNKSEVVPKVRLRKKSKRDVDRRTQPASATTNSLSTQDLQDEVNCNKSIIPGTQKIYVKTWGCSHNNSDGEYMAGQLAAYGYKITGNQEEADLWLLNSCTVKNPAEDHFRNDVKHAQRLGKHLVVAGCVPQGQPKLGYIGGISVVGVQQIDRVVEVVEETLKGHTVRLLKQKKHEGKKIGGAPLDLPKIRKNPLIEILAINTGCLNQCTYCKTKHARGELGSYQPEELVERARQSFQEGVCEIWLTSEDTGAYGRDIGVTITELLWQLVEVIPEGCRMRIGMTNPPYILEHLEEMAKILQHPRVYSFLHVPVQAGSDNVLLDMKREYSIDDFRHVVDFLRERVPGITIATDIICGFPTETEEDFEETMSLVEHYKFPSLFINQFFPRPGTPAAKMPQVPAQAKKARTKKISTLFQSYRPYDHKLGQRQQVLVTEVSHDKQYYVAHNKYYDQVLVPKKEEYMGKMMEVIIVETGKHFLKGQLVGDEADVITPSIAQPLAHGQISGIPHILQTPEPPESWSWLTITMAIVVGTFLLDLARILVYHLLYTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCN7</accession>
    <name>A0A914BCN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073993.1">
        <property type="nucleotide sequence ID" value="XM_038218065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218065.1">
        <property type="protein sequence ID" value="XP_038073993.1"/>
        <property type="gene ID" value="LOC119742048"/>
    </dbReference>
    <dbReference type="GeneID" id="119742048"/>
    <dbReference type="OMA" id="NIEGRTW"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="542" mass="59736" checksum="7514534B9C730144" modified="2023-02-22" version="1">MGPGTRSEAARTVMESLHVVTVEPIMFVLSMTNYMRTPASQLLVLHKVCIQSYNDTVCGDVDEKSAAVENDVQANAAHWNFLLKMALFIPGAIVSSLYGPLSDRLGRRMFLIIPSLGSILGAVSFLFQTYFPMMPLDYLIASEIAVGLSGNVVTAYIIAKSYLCDVTDGTNRTKRLGVMKAMSHIGGPIGAFLSGVLIDMKGFAPVYFILAGIHVLVVLYVVFWLEETVDYESDQELSSGGDEDDTSEDEERAEDEEIETKGKEEPQAGQEKVEKEGEADDGKRERFWGETRDSIRQSFREVWKSLRSMLLVCFRERLGCRRKYLLLAMLIGIIHNICSTAEMDLIVLYTKHSPLNWTATTIGVFISVRTALKAATLVLGLPAIFKIVKNHSMQLDLGLTSIGIISTSAALTMIAFAKSTTVMMIAAAVGMLVSFPSVTITSIKSKLVEPQEYGSLFAVTALIQTLTSVASSGLFNNLYAALLPIWPGLPFLVTVGFYALSLLLVLYIWYDVKVQSKEEELMTDRPGPKYKELKNIEDGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDD3</accession>
    <name>A0A914BDD3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073855.1">
        <property type="nucleotide sequence ID" value="XM_038217927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217927.1">
        <property type="protein sequence ID" value="XP_038073855.1"/>
        <property type="gene ID" value="LOC119741956"/>
    </dbReference>
    <dbReference type="GeneID" id="119741956"/>
    <dbReference type="OMA" id="ERYCAVM"/>
    <dbReference type="OrthoDB" id="6159456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="75"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="436" mass="49000" checksum="036382A51256DF5E" modified="2023-02-22" version="1">MEHWNVSINSSTAATETTSGTYMMMNVTDVGNYSSTAPTPTQVLLTPLDELVFQDGVTVAFIIAYAVVMVPAVIGNLFIIFAVAFHPDLRSQHSNTYNINLAVCDLMVVAAECPLMILQFLIRGETAESFFTDSVCRLTFLLNGFFGTVSILTMLAIGVERYCAVMHPLQMIGENTATRARSVIFFFWSFSILTHLGQLAIYGEVKTWHYINSDGERFDVTICMSSRPEQEQVFAHIYATTVFILVYGSTFLTTLVLYIRILQHLIKRKSVSPDQILEAGNAPSTRRRGKKKHVAPKTCTEAVQKTFRMLSCSVLSYLICYSLYFYINLYYIYYGLSEWNGMALILIGNWFGALNSLINPIVYAVFVGQFCTVFKAILTGSWRRRRSSSSTIQIRMASGGRSENRRVRRPKPKPGSTRRESRVASIDGQSSITDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFG3</accession>
    <name>A0A914BFG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Presequence protease, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074671.1">
        <property type="nucleotide sequence ID" value="XM_038218743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218743.1">
        <property type="protein sequence ID" value="XP_038074671.1"/>
        <property type="gene ID" value="LOC119742620"/>
    </dbReference>
    <dbReference type="GeneID" id="119742620"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="12">
        <location>
            <begin position="507"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114719" checksum="D5F372448F5F3950" modified="2023-02-22" version="1">MQRVRGISPGLICSTRYMWQIFGRHKSHRLYSSASALKAAESYQPGQRIHGFTVEEVIPVPELYLTAVTLSHDVTRAKHLHVARQDSNNVFSVGFRTTPMDSTGVPHILEHTTLCGSQRFPCRDPFFKMLNRSLATFMNAWTASDYTMYPFSSQNPKDFSNLLSVYLDAAFFPRLRELDFRQEGWRLENEDNQDPDSPIIFKGVVFNEMKGAMTSPEQIFALHCQRNLLPSHTYSHNSGGDPLHIPRLTWQQLKDFHATHYHPSNSRFFTYGDLPLEGHLEVIQQQALASFSPITPETEVPNEVRWTQPREKHVHCAPDAMAADPEKQTTVSVSFLLNNLTDSFEGFTMSILSHLLVSGPTSPFYQALLQANIGSDYSPVLGYDGSTKDASFSVGLQGINEKDIKQVKNIIEETFKKVVETGFEKERIDAVLHKIEISQKHQSTTFGLQLIASLMQSWNHDADLANILRVNENVQRFQTCLAENPRFLQDKTEEYFLRNNHRLSLVMTPKEDYNEELDQEEKRLLEGMVSGLSQEDRKDIYVKGQELAEEQDKEDDIAVLPTLKVSDIEPELKRTTLEFKQTDGIHVQCCEQPTNGMTYFRAVSTLRSIPEDLMPYIPLFCAVITKMGAADMTFNEFAQKEELKTGGLNISHHVCQDPNDMSSIEQGVSLTSFSLDRNFEDMFNLWSDIFNSPNLNDMDRLTTLVRMRASELAMSIPDMGHAYAMKHAGSTLSPVGRIQEICGGMAQVSFMKRIAESSDLTETMEKLRQAAGLILNKDNMRCALNSGPEFMNEALGHLQRFLGTLPGASQEKGLPLLTKIDGFNSESQWTHFELPFPVNYVSRGTQAVPYTHTDFAKLRILARLMSAKFLHREIREKGGAYGSGATLGTEGSFKFFSYRDPNSLQTLETFDKAVEWAIEASYSQQDIDEAKLSVFSAVDAPVAPSDKGMSLFTSHISEDMKQEQRRRMFAVSKEDLQFVAQRYLALGAQVDSVTLLGPQNTATKSSKWNILQDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGG2</accession>
    <name>A0A914BGG2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="RefSeq" id="XP_038075348.1">
        <property type="nucleotide sequence ID" value="XM_038219420.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219420.1">
        <property type="protein sequence ID" value="XP_038075348.1"/>
        <property type="gene ID" value="LOC119743078"/>
    </dbReference>
    <dbReference type="GeneID" id="119743078"/>
    <dbReference type="OMA" id="MISQGFE"/>
    <dbReference type="OrthoDB" id="5974730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="491" mass="55052" checksum="9F4E10F480BE707F" modified="2023-02-22" version="1">MSSETVETASNSGLLAGVAGLVGLDAPSFLYLMTLLLCYPLCYISRTYLHGQSQFIKHVYFILCGLTLASLNFGYDIVYSMISVLVNYVLLVTVGGSQLSVALSFAFNMGYLLTAYIVLSTDGYDVMWTTPHCILTLRMIGTAFDLFDGHKDESQLSAEQKQLSIKTVPSLLEMCGYTYFXGGFFAGPQFSIRRYLDFTAEKLLDNDQGHPPACVMPALSRLGVAAVYAILECVLAPMFSNALLQSEEFANSSLLYQIIVVGIWHKIVFFKYCTVFLIVDGSCIMSGLPYNGKDEKGNALWDACTSVIPWKLETATVTAEYIRSFNITTNVWVSRYVFKRLKFLNNRYISQTAAVMFLAVWHGMYIGYYICFGLEIFVTATETFVQDAVKRYPPLTKLVSNPALKFPIFALLKITVSLSVGYPLVGFVLLRWRRIRLVYGAMYHIPTLVLIIFPFLYQMVILPRLIKMERATKKAAEAAQDTKNSENEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHE9</accession>
    <name>A0A914BHE9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 47</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075698.1">
        <property type="nucleotide sequence ID" value="XM_038219770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219770.1">
        <property type="protein sequence ID" value="XP_038075698.1"/>
        <property type="gene ID" value="LOC119743382"/>
    </dbReference>
    <dbReference type="GeneID" id="119743382"/>
    <dbReference type="OMA" id="FVETATM"/>
    <dbReference type="OrthoDB" id="8655982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22331" checksum="72715F9CCDA95A50" modified="2023-02-22" version="1">MDMDDSTVTTTTRVVRPFKIIAVILIVLCGVVMIAVLANNTWIRAAGFYQGLWNECYNGTRIVPTLPSGLPSAQPPTDIVCHAAPATGWLIACKALSIVALLLTIFSLVFALVALIKGKRFANMYKIAGVLLFVSAVFMLVTLALFPAMSIQEDVFLLRSNWELAWGYGLGWGAFLLQVVAGILLLFAPDKQEIYYSEKTYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIR0</accession>
    <name>A0A914BIR0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076173.1">
        <property type="nucleotide sequence ID" value="XM_038220245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220245.1">
        <property type="protein sequence ID" value="XP_038076173.1"/>
        <property type="gene ID" value="LOC119744364"/>
    </dbReference>
    <dbReference type="GeneID" id="119744364"/>
    <dbReference type="OMA" id="HCFAIGF"/>
    <dbReference type="OrthoDB" id="6343173at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824170" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="280" mass="29021" checksum="FF6FD0F517246405" modified="2023-02-22" version="1">MKICVITALSIALLLGNSVKLRASVTGPVPSDGDGPVSQVCQQCCQGPAAIPGIPGLPGPAGQMGPYGQPGSKGVAGQQGQKGEIGPIGPMGERGAPGNIGSKGDDGIGLPGKIGPRGPPGLVGAAGQAGVKGQKGEPGETPDESNQRVAFTVVRTSNSDKSTSHDTRLPFQQTETLLQGTSFNLETGTFTCTVPGTYVFMFSVCKDYDTSITAYIHLRKNNDWVASGQSYDTSSHEQMSGSAVLVLQRADTVYLTFRGSALSDSTYHYTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJR4</accession>
    <name>A0A914BJR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076339.1">
        <property type="nucleotide sequence ID" value="XM_038220411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220411.1">
        <property type="protein sequence ID" value="XP_038076339.1"/>
        <property type="gene ID" value="LOC119744476"/>
    </dbReference>
    <dbReference type="GeneID" id="119744476"/>
    <dbReference type="OMA" id="FIMHISC"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="497" mass="54130" checksum="77B7A170FDC46514" modified="2023-02-22" version="1">MTDSETEVTPNSPSKSMSSLERAQRRWVTVEPIISLAVVGSITISLIRPFYLKGRLGESMFNITEQEEIAKCQANNSDGGVIEDEIQAQASLWLLYLSTAAKIPVVVSSIILGTLSDRLGRKLCLVIPIFGFICQEIVYILSVYYKLPLPVLLVGDVIQGLSGGYMSLFAGCLSYITDVTSEKQRTMRIAVAEMLMLLIGGIVQVSSGYMLRDLGPIPPLAMALGLNVLCLMYVAIPGILIDTVDRKTISEHRKGFKEAGMSVVKLLKFNENGRRWQMLLLDFFLFFVLLNVNGAMSIYILYGSAEPFCWSAATAGLVAAFGLIAGSIGMVAGTKLFSCCLDEYWIMQISCLSSLAFDVVMGVSQSTALVFVGNALGALRGMGTPVARSVLSTIVDPSEIGAAFSIVACMDTISSFSATLMIPSIYAATVSYMPPLIFYVLSGLSFIPNVIVLILQIHWPRRRGYEPIKGSSTYDDCSAEEDWKQNHTTSMSILETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK48</accession>
    <name>A0A914BK48_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076295.1">
        <property type="nucleotide sequence ID" value="XM_038220367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK48"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220367.1">
        <property type="protein sequence ID" value="XP_038076295.1"/>
        <property type="gene ID" value="LOC119744438"/>
    </dbReference>
    <dbReference type="GeneID" id="119744438"/>
    <dbReference type="OrthoDB" id="6343173at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037317917" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="138"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="28022" checksum="9F4506BC0D64F0C4" modified="2023-02-22" version="1">MKICVATILSIALLLGNSVKLRASVTGPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPVGPMGPYGLPGSKGDAGQKGYIGPMGERGAPGNTGSKGDDGIGLPGKIGPRGLPGFVGGTGETGVKGQKGEPGETPDESKQRVAFTVLRTSHSDTSTSQDTRLPFQQAETLLPGTSFDLETGTFTCSVPGTYVFTFSVLKYTNSGSLTINLVKDNYKAITTHGEPNQRGQLSGSAVLVLQQGDTVYLTMHGRAYSGTTYHYTSFSGFLLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKK0</accession>
    <name>A0A914BKK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075992.1">
        <property type="nucleotide sequence ID" value="XM_038220064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220064.1">
        <property type="protein sequence ID" value="XP_038075992.1"/>
        <property type="gene ID" value="LOC119743893"/>
    </dbReference>
    <dbReference type="GeneID" id="119743893"/>
    <dbReference type="OMA" id="AFYYNNF"/>
    <dbReference type="OrthoDB" id="5967704at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="39861" checksum="CC2075D720810106" modified="2023-02-22" version="1">MAEGMDVQTTMASGMTTGTPYTITVVSVVKACLLAVTTTLILLGNSLCLIVLRYTHDGVSPVTKLFLISLTISDLLVGVLVGVPVVGSTALQSWPYGDAYCTVVAMCHALYFNAGMSVLAINIERYIAVIWPLRYPSIVTMTRAAIAEVCIICILVVWTLLYVLIPNRSAFYYNNFNLCFIDADAGDDVMGQLGMTLFIALPMLITVMLHIRLFFLATRHASKVGNITLGDINSTSGASQNSEGDVEQRAQSSPPTQRREGRQRVNSDRPSPETKAARTFFIMALVAAISWTPYYTTISWENFREEEVPEALAFVAQILLLLNSLWNVVIYYARNDAFRKTANRLLGCCFRVHSTNGEVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLM0</accession>
    <name>A0A914BLM0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077009.1">
        <property type="nucleotide sequence ID" value="XM_038221081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221081.1">
        <property type="protein sequence ID" value="XP_038077009.1"/>
        <property type="gene ID" value="LOC119744888"/>
    </dbReference>
    <dbReference type="GeneID" id="119744888"/>
    <dbReference type="OMA" id="RNHAPAN"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36423" checksum="C2C5DD9D68288D3E" modified="2023-02-22" version="1">MEAANRTDDFDNTHVLPLTISLGVIGILGNGLVCVTIYRARFMHNPTNYLIIHLAFADLLVCSTQVAFQDSFFPDTKSMFLCIFFSREILVWFSILLSSMGIMSVTIERYLAIVHPLHYPRYSTPRRLWLAVAGMWFSATVFSALHVVLPSQDLAQTDCLFPGKLGLHSPVIRAGVAINSFMYLCPMSCLFYCYFKIILNLRRGAHRQRRDRNHAPANELLGAQRRVAVVLAIVATAYIILWLPVLLGNVFITLDVGSANEFLFKMFRWTTILPVINSIINPVIYAFKYKEFQRGVKEAVLPWCFNRRHRVATANDVIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM43</accession>
    <name>A0A914BM43_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038077189.1">
        <property type="nucleotide sequence ID" value="XM_038221261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221261.1">
        <property type="protein sequence ID" value="XP_038077189.1"/>
        <property type="gene ID" value="LOC119745037"/>
    </dbReference>
    <dbReference type="GeneID" id="119745037"/>
    <dbReference type="OMA" id="PPRQGCM"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="624"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="832" mass="93552" checksum="5CF8F113CA06C1E3" modified="2023-02-22" version="1">MEAIYMSSTNTEERDSPRALLTTGDGTETRVPRKLPKIILLIVCAVIFGGVVAVFGSSASQNWGLPPTPTSPPTPTKPPTQTTPPKPTKPPTPTTPPKPTKPPPPTTPPTPSKPPTPTTPPTPTKPPTPTTPPTPASIILSSMDKTQDPCHNFFEYACGGWNNRQVIPNDKLKVTRFTELDDDLQEKLKELIGRDPQPSEPESFSKVRTFYSACLDLDTINGLGARPLTDTLQSLGGWPVLGSNPGGSWSQISYNFERLWATLSSQYNIDVVILTEVRINLENTGRYILQIDFPEFTVPLQFRADRQKRLASLIPESFSKDFGRHLLLLDELEEKRAAYLQYMVDIAVALGGDQSEASRDMNDVLEFEKRLARDAVAAISDVFDLPDTLTLRNLQTTYNEVNWASLYRYLLPSSVQPSVSDSESIVVISPSYLRSVARLLRWSRHRVVANYMIWRLVSKMVPYLGEEYVVIHQKYLKAIRGISAAEDRWKLCTEQVNTVLPFATGRMYVDEYFATDTKTKTEEMVGQLRRALRAMFGSVRWLSYSDRAKARQKLDAMGVSVGYPDWLKVNATLDAKSVDLVVTSNSYFTNVVNYGRRVAQTQLRRLRLPVDKSLWDDSGPAVINAYYSPFDNGIVIPAGILQPPFYHADMPWYSNFGGMGVVLGHEITHGFDNKGRLFDQHGNIENWWSYTSIYGFTRAAECLVNQYSGFVMPENGKRVDGQLTEAENIADNGGLREAYKAYKTNTPSVQRQLPGLKDLTNDQLFFLSYSQVWCSVMTREGADLMVKYGKHSPGRFRVIGPLQNNENFQRAFGCQSGNYMYKSQYSRCKVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMF1</accession>
    <name>A0A914BMF1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077294.1">
        <property type="nucleotide sequence ID" value="XM_038221366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221366.1">
        <property type="protein sequence ID" value="XP_038077294.1"/>
        <property type="gene ID" value="LOC119745138"/>
    </dbReference>
    <dbReference type="GeneID" id="119745138"/>
    <dbReference type="OMA" id="SHVEQVF"/>
    <dbReference type="OrthoDB" id="6605214at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029159">
        <property type="entry name" value="CA109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16234:SF5">
        <property type="entry name" value="AFG2-INTERACTING RIBOSOME MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16234">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN FLJ20508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15011">
        <property type="entry name" value="CA109-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="23962" checksum="7A46C0EE475FEE94" modified="2023-02-22" version="1">MSPVRKTTSAGGEETIHKQLRRSFKMVGQQVTVWQEASERSVSVVQSLVNHAEQLQCCRRAAKDGCSDVLQRFPDLKDRLEFKLLGSMEVILARLKSQLLTMEGVCKKHTQHSAYSLNAYHIHYREVGVAKGLVRSATWPSIADMLQWLADVDLLYRRLYAEKQWLYDTISYDNLDEFPSLVSRWKRNDGELTAVKNVLAHVAFFMEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN99</accession>
    <name>A0A914BN99_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038077763.1">
        <property type="nucleotide sequence ID" value="XM_038221835.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077766.1">
        <property type="nucleotide sequence ID" value="XM_038221838.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221835.1">
        <property type="protein sequence ID" value="XP_038077763.1"/>
        <property type="gene ID" value="LOC119745473"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221838.1">
        <property type="protein sequence ID" value="XP_038077766.1"/>
        <property type="gene ID" value="LOC119745473"/>
    </dbReference>
    <dbReference type="GeneID" id="119745473"/>
    <dbReference type="OMA" id="GIEPMIM"/>
    <dbReference type="OrthoDB" id="6019201at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09820">
        <property type="entry name" value="dual_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000008">
        <property type="entry name" value="Dual oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000006">
        <property type="entry name" value="Dual oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000059">
        <property type="entry name" value="dual oxidase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034821">
        <property type="entry name" value="DUOX_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF208">
        <property type="entry name" value="DUAL OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="20" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1216"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1276"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1308"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1339"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="961"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="24">
        <location>
            <begin position="1361"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1641" mass="187462" checksum="5A13C5B56F71026A" modified="2023-02-22" version="1">MPTTVAPTDMPTTAATAAPTAAPTTAPTMAATTAPDATAAPTAAATMPAGPTPGGDGTTSSNGGQQTPATDTLTAEERIELEKNLGVFEYEHREYEGYDGWYNNMAHPDWGGAELPLTRRLPVAYADGVYRMAGQDRPNPMKISDATMKGQTGRPSYLNRTAFMTFFGQQVVEEILDAQGAGCPPEYENIEIPEGHEYKTMTENNPHGPVDFIPFLRTRYSFNTGFSPNVPREQLNEITPWIDGGLVYGTTKAWADALRSFEGGRLADNSGNVAGEGGFPEQNTLGLPMANVPPPAEAINHKLRDAKRFFKLGNPRGNENPFLLTFGILWFRWHNYWADKIYNQTMDHRDEWNDERIFNEARKWVIATYQKMVFYDWLPAFLNLTPEEISANVYTGYKSYVHPGITHEFQSAAMRFGHTLVPPGVYRRDSKCNFLNTSMESSNIPDNLFRSVHGVRTCNSFWNPQLPIREYDIENFLMGMASQITEREDHIVTIDLQRRVFGPLDFSRRDLMAQNIQRGRDHGLPDYNTARVSLGLPAVKNFTDINKLQHANDESGIPDEIFQNLKDVYKGDLSKIDIWPGGLLETTANGPGPLFRKIILDQFVRTRDGDRFWFESEQNGLFTKAQIEYIKNNITIYDVLILATKIKEGEIQKDPYHYYESDPCWDMHPNENRSLNENDMEECTQLYTFDYFEGSEISYALSYLAIGLFCLGVIGMLFICAKRRARAIEEVRKATRTKTRKGKGPETLLKFTAAEWCGYKSGTRPVQVALGPGKAIKVMNERGNKLYRTIDLTHHQKITLCVGPDGKQRFLLLHMEREYDLVLKFDGSESRGEFISEVESFLGSGEIGVGQERREIREKELLKMAITKEHRQKTLERFFRVAFAQAFDESVEAADLSELEHTDAHDVLNNELTKTEFAEMLSMAPDSLFVEQMFELVDKDQSGSLSFREFLDVIVIFAKGKPEDKLALMFNMYDIDRSGHLSREEFKIMLKSMMETVSASLEQQQLEDVISSMFKAVGFENKEELSLEDFIILMGDHKEDLSQAALQLQGADLPEAAQPAAVDRGATVIRRENAPSRARKTIVKAYADKDSVRPKTARSRYQSQVVKVETKKQTYTENKTQQKLNRFLRYIENNRLQIFYLALYNLVLAGIFIERAYYYSVEREHAGLRRIAGYGVTVTRGAASAMMFTYSTLLVTMCRNTITFLRGTFLHRYVPFDSALFFHKFVAIMALLYSILHTIGHAINFYHISTQTANDLSCLFRDFFHRSNELPKFHFWAYRTITGFTGVLLVMVCAIMYTFAFQYARRKVFNLFWLTHNMYAFYFFLMIMHGSGNLVQPPFFYYFFLGPVILFTLDKMVSISRKKAEITVVKAELLPSNVTMLEFKRPTTFEYKSGQWVRIACKTLNSSEYHPFTLSSAPHEENLSLHIRAVGPWTMNLRHTFDPNVVREHPYPKLFLDGPYGEGHQDWYQFEVSVLVGGGIGVTPFASILKDLVARSAQGQKFTCKKVYFIWVTRTQKQFEWLTDIIRDVEDKDVNDLVSVHIFITQFFQKFDLRTTMLYICERHFQKISERSLFTGLRSITHFGRPQFETFLQSLQDEHPSVNKIGVFSCGPPGMTNNVEKACTELNKYDGAAFIHHFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNM7</accession>
    <name>A0A914BNM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077311.1">
        <property type="nucleotide sequence ID" value="XM_038221383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221383.1">
        <property type="protein sequence ID" value="XP_038077311.1"/>
        <property type="gene ID" value="LOC119745158"/>
    </dbReference>
    <dbReference type="GeneID" id="119745158"/>
    <dbReference type="OMA" id="PIPNYLV"/>
    <dbReference type="OrthoDB" id="10397716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF418">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="36403" checksum="033B283E8B134CB7" modified="2023-02-22" version="1">METNVTGGAAEEVDALYNFISAVSWCVATPLSLVANIFSLLVVHRSPVRNDITQAYVASVSTIVMGLTLCLGPTAALSSITGGEWILGNGICTVQGLLLAAILSVLSVIMFIFSIERYVYLAHPLRYPVLVTFSRTRVIIAGMAPIGLLAVIFCGILSDWRGLYMSSWHACVPHFKDDIARSVYFCAYLLVKLIPAVIGYALHCSLLLIARRHLRRIIADMPSPHTVRADPTLSRAAVLIFRRLKLNIARWVLLSFFALFFLAMDLIPDLACLYPIPNYLVLPGNIAFLFVSCALPIAHLYSNRSLKRTANQTLGCCSCRCENKNLHSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPT7</accession>
    <name>A0A914BPT7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTHRC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077507.1">
        <property type="nucleotide sequence ID" value="XM_038221579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPT7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221579.1">
        <property type="protein sequence ID" value="XP_038077507.1"/>
        <property type="gene ID" value="LOC119745305"/>
    </dbReference>
    <dbReference type="GeneID" id="119745305"/>
    <dbReference type="OMA" id="PCQGAER"/>
    <dbReference type="OrthoDB" id="5985978at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057873">
        <property type="entry name" value="CTHRC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25815">
        <property type="entry name" value="CTHRC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037838632" description="CTHRC1 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CTHRC1 C-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="21724" checksum="9C39673A6DFF16F7" modified="2023-02-22" version="1">MTSTATLGLLLFFGAITLLNFSLVDTWGSTCDQGSPGPPGPPGPPGPSGDSGAPEFLDYNNWRQCAWYSSNGNDYDTNINSCTIQKRYSDSALYVAFGGNLRLYGCDGCCKRWYFTFNNNECSPVPIDGTVYQTNTYYMNLHRHRNIEGYCHTVGAGEVIVRFAVGDCPGYGNYDAYTGWNSASRIIVKEIPASPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQB4</accession>
    <name>A0A914BQB4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078488.1">
        <property type="nucleotide sequence ID" value="XM_038222560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222560.1">
        <property type="protein sequence ID" value="XP_038078488.1"/>
        <property type="gene ID" value="LOC119745894"/>
    </dbReference>
    <dbReference type="GeneID" id="119745894"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="618" mass="67080" checksum="B4637766EC1E7CF5" modified="2023-02-22" version="1">MYQISKHPRNLYTRLQTQEISKSVRKRYIVIACVVVVVILAAVGLAVGLTLGLGDKDDTSPQTGVYRKAAVATDHGPCSEMARDILLDGGSAVDSAVTAALCLGVASPQSSGLGGGLLMVIYSRDGSTETIIAVEEAPAASDFDMFVNDTDQANYGAKAVSVPGELAGLWAAHQKYGVLPWKRLVTPVIDMAEHGFPLAWHTAYCLKILEKDFDRWPILRQLYTKPDGSLMEEGDIITAPTGLVQTLRAIANEGGAAFHGGEMGRKLVQDIRDQGGIITFEDLTSYNVTWEHPVAFSMREGQHRVMSTPVTSSGNLVQFTVRVMDECNLASVNLDTYEGKLKMYHYFIEASTFAIGLRLHIGDYGKAENAKSVAALSSKEYARTICSKINETHVTYPSGQDYDTFNGLPDTFRAAPALEQADEGEALDTINGDTSHLSVYSEHGDAVSMTTSVGQYFGSRTFSNQTGIFLNGHMGSFYYNGRSPPWEANRLAPGVRAMSTMSPSIIADEDGVYGVIGSSGSMRIISTNAWVLLRSLWGSESLSDMIDSPRVYPYRSASLNRTYYEKDFPEDLVEGLKAMGHNMVSTSSFPAAQGILRGPGSTIQAHSDRRKHGYPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU54</accession>
    <name>A0A914BU54_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079451.1">
        <property type="nucleotide sequence ID" value="XM_038223523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BU54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223523.1">
        <property type="protein sequence ID" value="XP_038079451.1"/>
        <property type="gene ID" value="LOC119746544"/>
    </dbReference>
    <dbReference type="GeneID" id="119746544"/>
    <dbReference type="OMA" id="IAKSMHE"/>
    <dbReference type="OrthoDB" id="10426732at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="263" mass="29046" checksum="BB828913531828A9" modified="2023-02-22" version="1">MENFDAPALAPEISYPSSPEPSDDLEDMYQGLTVESIHCAMEEQEEHGRSPPLVRSASSPDRIFANHNLSGNHHQQERGSDSFDEASTSTLTPPPSISPDPPPPPPSPPGSPPPAHHARPTGITQAEMRAPSPDKMYLDMVGDLEVMMEIAKSMHELARHTKSLLHVAYERVDLSDPRVRNLGMSGVLKDLRQESAHSVVDGQRAQLRYEKVLSDVRRLRRCLRNLGFWRLGGASGAPPLDPLVPDTPTWGLPPHSYFTHDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0S0</accession>
    <name>A0A913Z0S0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044601.1">
        <property type="nucleotide sequence ID" value="XM_038188673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0S0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188673.1">
        <property type="protein sequence ID" value="XP_038044601.1"/>
        <property type="gene ID" value="LOC119719280"/>
    </dbReference>
    <dbReference type="GeneID" id="119719280"/>
    <dbReference type="OMA" id="DKVSCDR"/>
    <dbReference type="OrthoDB" id="10625278at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="17752" checksum="85C78B1C176E886D" modified="2023-02-22" version="1">MDRDRKSPDKDKVSCDRGDPDVDGQSWAGSPGSSPAPDLKTTVSLEGEESYLCDDKLKKQLDTLVIRENSVDARLQEVETRLASAETKLRSCNDILALIGLLKDRIRLVDEDEILPSNAESSSSFSGHQAEGYASRSPLRSPNSPMRSAKSPIRSPKSPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0T0</accession>
    <name>A0A913Z0T0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045433.1">
        <property type="nucleotide sequence ID" value="XM_038189505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0T0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189505.1">
        <property type="protein sequence ID" value="XP_038045433.1"/>
        <property type="gene ID" value="LOC119720009"/>
    </dbReference>
    <dbReference type="GeneID" id="119720009"/>
    <dbReference type="OMA" id="WWRQLIA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16415">
        <property type="entry name" value="HAD_dREG-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27774" checksum="A97B539073FB5160" modified="2023-02-22" version="1">MIGKQCSAMLRYKVITLDIHNTLMRVNQSTGQQYSRVALQHGVTLDPHILDKAFHSALGEQRAKHPNYGIHAGMSSSAWWTDVVRKTFTTSGYSNSEVVSKIASTLYEDFKKPMTWDIFPEVKSTLTSLNRLGVCLGVISNCDERLMEVLQATNLASHFAFILLSVYTEHEKPKPEMFRLALDRLRVQPEECLHVGDNIRQDYEGARAIGMDAVVVDRNQSLAKTHPDISSDHFIPDLTKLEMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z164</accession>
    <name>A0A913Z164_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045407.1">
        <property type="nucleotide sequence ID" value="XM_038189479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z164"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189479.1">
        <property type="protein sequence ID" value="XP_038045407.1"/>
        <property type="gene ID" value="LOC119719989"/>
    </dbReference>
    <dbReference type="GeneID" id="119719989"/>
    <dbReference type="OMA" id="TNSETWT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037023497" evidence="2">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="22486" checksum="220A50A1ADEB719E" modified="2023-02-22" version="1">MRCASGASYAIAFKMVLLSLVWLPQVPARVPATDLDISSSPPPPTRTTSSSSSSLSSPPAKPTQHYTLSSSSLFSKSMQSSDTASSHRDTSGHTESDNAKSPPSQNPLQRTAITTPPGPPSVFTSEGDAVLDRSTTSSGAEGALVYYGSSGSPGLRGTDLQSVSSTTASTNYVCDLKCGDVMARKQGICGCNAKLTGRPFLKSGIKRSALHRPMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1N6</accession>
    <name>A0A913Z1N6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisomal leader peptide-processing protease</fullName>
            <ecNumber evidence="1">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038045733.1">
        <property type="nucleotide sequence ID" value="XM_038189805.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045734.1">
        <property type="nucleotide sequence ID" value="XM_038189806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1N6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189805.1">
        <property type="protein sequence ID" value="XP_038045733.1"/>
        <property type="gene ID" value="LOC119720213"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189806.1">
        <property type="protein sequence ID" value="XP_038045734.1"/>
        <property type="gene ID" value="LOC119720213"/>
    </dbReference>
    <dbReference type="GeneID" id="119720213"/>
    <dbReference type="OMA" id="CWKSTEW"/>
    <dbReference type="OrthoDB" id="17845at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031998">
        <property type="term" value="P:regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039245">
        <property type="entry name" value="TYSND1/DEG15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004:SF0">
        <property type="entry name" value="PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="621" mass="66329" checksum="3BE31D50560E80E0" modified="2023-02-22" version="1">MDSRQIGLADSCVVRVHSHKSFRPGNTTSQSEYSCSGVVIDPQNGLVLTSGQVFSEVVNQGSRGPILSSRRRGSYVYFTAKELKKNVCIDVILSQPVQPHLALLPASSSTKRIPSSSHNHSNLGTRTKRAELVLMWKCQEFDNVLQTIVPEKDGWKFTDSGESDGARTNQSGDSNLRSDPETDSAVGQCVEPCGLSSVSKNLPGENFISWFALLKVGNDCNDSGRLGHALNAIRPSTLQDSFLQQGDPICLQTTPFGATCPAVFLNSISKGIVSNLAGPRHQLVMTDARCIPGSEGGGMYATRRGKNNRQESVLAGVIVAPLCWKNNEWIGLTLVCSIQAILESLRSITDSPPTKKISPAPALPEGSKSSRASPPSTVQQCMRSVVLIKVAGVWGSGVVIDAERGIILTCRHVVQKATNHHVRVRIDWPYICWEDATVVHTTSPTSPFDLAVLKLEGDLGALKEAHGRAGIGTARSYSPGQSVIIVGHALLSPELDLLPSVSSGVMSKVITANGAPVMLQSTCAVHAGASGGAIFCNGTGQLLGIVTSNARDMDTGASFPHINFSVPWTFIGPILNEYQQTEDVSGLYRLDADDDQLTALWNLDSQGIAQGKTAPQTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2D0</accession>
    <name>A0A913Z2D0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045857.1">
        <property type="nucleotide sequence ID" value="XM_038189929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2D0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189929.1">
        <property type="protein sequence ID" value="XP_038045857.1"/>
        <property type="gene ID" value="LOC119720284"/>
    </dbReference>
    <dbReference type="GeneID" id="119720284"/>
    <dbReference type="OMA" id="CCSSEIW"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52072" checksum="096C565F3464D91E" modified="2023-02-22" version="1">MSQTAHHAEAGLPARLLSAVHIIPLRRPRSTVASVVSFVKAFTARLFFAIHGIVTVWRVASVRGSSVYYLMVMPVALMPGEMIFTLQTTDAGEWKWLCPSALLYLASVVPGLWMLQMDLYQKRMDYRDHMHWKECAIKINYNHTSFTQIQGLTIPVGLADDEWALALEQFLLCLLILGRWLLPKGSLTREQLSQLLMVYIGMAADILEFSLENLREGAVVCNKLIIMVILALWSWSLIQFAMVLTSVAGPKIRVFNHRGRDNSSSSISSTRRVRATVAELQHPDVQHHRRHNGCCSSEIWALCISLIMQDGPYLAMRLYLIIRFHIINQMMLFFTLKNMMIFLLTVYRIYVLRMTNNRKRKRLHQQAIKVRVDPEDGLMKSGLGLPLDLGLGTPPEVVPTAEDKEITRPAGRETLQQNGFTERDSDVELTQIVPHVEERMRGKPRLREDSLEEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z363</accession>
    <name>A0A913Z363_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046273.1">
        <property type="nucleotide sequence ID" value="XM_038190345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z363"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190345.1">
        <property type="protein sequence ID" value="XP_038046273.1"/>
        <property type="gene ID" value="LOC119720609"/>
    </dbReference>
    <dbReference type="GeneID" id="119720609"/>
    <dbReference type="OMA" id="INVHFTI"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000012">
        <property type="entry name" value="AP-3 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="176"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="416" mass="46781" checksum="9481459EA906DA5D" modified="2023-02-22" version="1">MIHSLFMINPSGDIFMEKHWKSVIGRSVCDYFFEAQNKVSCHDDVPSVISTPHHYLISIYRNQLFFVAVVQNEVPPLFVIEFLHRIFDTFSEYFGDCTETTIKEHYVVVYELLEEMLDSGFPLATESNVLKELIKPPNILRAVVNTVTGSSNVADTLPSGQLSNVPWRRSGVKYTNNEAYFDVIEEVDCIIDKSGSVVFAEIQGHIECSVKLSGMPDLTMSFVNHRLLDDVSFHPCVRFKRWESERVLSFVPPDGNFQLLTYHIGASSLTAIPVYIKPNISFRDNSGRFELSIGPKQTMGKNVENVVITSDMPKQVLNMNLTPTQGTYSFDPVGKTLTWEVGKINPQRLPSIKGSVSLQSGAPPPEANPTINVQFSISTLAISGVKVNRLDMYGEKYKPFKGVKYITKAGKFQVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3A5</accession>
    <name>A0A913Z3A5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038046192.1">
        <property type="nucleotide sequence ID" value="XM_038190264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3A5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190264.1">
        <property type="protein sequence ID" value="XP_038046192.1"/>
        <property type="gene ID" value="LOC119720554"/>
    </dbReference>
    <dbReference type="GeneID" id="119720554"/>
    <dbReference type="OMA" id="ECHHTHG"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="290"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="664"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="22">
        <location>
            <begin position="853"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113000" checksum="79B42E3CB302F9FF" modified="2023-02-22" version="1">MAQADCFADEYGDIKLKIITDVFRPFVVENLNLTSEFLSLLYSKNGLNHETMGHTEQLLREASPVNVLLDRLARLNRKGTYTAFIECLRSKGSAFIADAIEDRADVDSEALDLLKHLIQAFHEQLNQIDPASMLPYLRCLNTEEKESIRQTTHNFGDTRGAVFLLGIICKKGKVVVGQLMKGLRETGHGNLAQKLSKLFCCSTFADGEMDDNCCGASSTCTGAIVDDPNMFQSGTPAENTSGFDEPSASGACALKPGELIRSSDRDTPEDDSLDGEPKLLRLRGYQEELVAASLQGTNSLVVAPTNSGKTYVAARLVQAFLDRESGVGPRFGNPPQVIKDGSNKVVFLVNNVLLVDQHLQVIQLFMSDNSIMGLSGETSNPGSLVDLLDEHDVLVMTAQILVNALQGVKDDNERLELSKIGLLVFDECHHCQKGAPYNKIMSQYCDIKLSSPQTHRPQVLGLTASMGVGKASNLSEAESHIMKMCANLDVEKICTVQDQQNKEELRQIRDKPEEDIFEVPGRKNNGFAKAIVEIMEKIEARISQIPEGETWLKQPKPRYGTQGYEQWLVEMGKHFIEHVANDENGTRLATCKDHLKEYNACLYINRDARTQDALDHIKNFLESLELKTTSGFSPYEQQLVDFFQSKQKCLKALAESSLRDLQNPLLDRLTKILTETLLGRADSRGILFCKTRATTKALHAWLQATPSLQCLQAGILIGSGGTEGMTTNKQGEFLDKFREGKHRLMVATSVAEEGLDIQQCNVVICCNYISNEIGRVQAQGRSRARGGKYFLVVSEELTLTSREIQNRIREKMMYKATDSLQEKFDMNPKAFLEKIVEIQEMNRNERQARERALARLQHNKELMDVSLICRKCRRHACTLDDLRCIKKNHHVVLNAAFLKQCRLVPHNKPCQLSDIEKLKRIMCGKPTCPQKWGSQMKFNDCVVFALSPTNFIFQPLHKNKRGFKEWKLVPYKIAKMDMEELREVSFTMEVEEDNINEDDGDIWAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z470</accession>
    <name>A0A913Z470_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038046512.1">
        <property type="nucleotide sequence ID" value="XM_038190584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z470"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190584.1">
        <property type="protein sequence ID" value="XP_038046512.1"/>
        <property type="gene ID" value="LOC119720752"/>
    </dbReference>
    <dbReference type="GeneID" id="119720752"/>
    <dbReference type="CTD" id="9942"/>
    <dbReference type="OMA" id="NSCALGG"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="295"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="530" mass="57790" checksum="A5525FF96F8CAB6E" modified="2023-02-22" version="1">MAGSLENLFLGFDFSTQQIKAIAINDALRVVQEFLVQFDNDLPEFRTQGGVHIQADRLTITSPTIMWVKALDLLLDRMKAAGFNFSRVIALSGTGQQHGSVYWKAGASSTLGNLQPNQLLHEQLKDSFAVNDSPVWMDSSTTAQCRHLEGVMGGPQRVADITGSRAYERLTGNQIAKIHQQNQAAYSSSERISLVSSFAASLFLGSYAPIDYSDGSGMNLLDIRSKCWCPQALDACAPGLANLLGPPVPSSTNLGAISPYFVDRYGFSAECQVIAFTGDNPASLAGMALKEGDIAVSLGTSDTLFLWLKTPRPALEGHIFVNPVDVQAYMALLCFKNGSLTRERIRNEFSMGSWDTFNRLLESTPPGNNGNIGVYFDVQEITPSAVGVYRYNSNNDQVESFQPAVEVRALLEAQFLAKRLHAENLGYLVEQGSRVLATGGASSNRAILQVLSDVFNAPVYVLDVANSACLGCAYRAKHGFHGDNVVSFRDVVNASPAEYKLAAMPNQDTKEVYNSLLARYKLLEEMITQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z531</accession>
    <name>A0A913Z531_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046121.1">
        <property type="nucleotide sequence ID" value="XM_038190193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z531"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190193.1">
        <property type="protein sequence ID" value="XP_038046121.1"/>
        <property type="gene ID" value="LOC119720508"/>
    </dbReference>
    <dbReference type="GeneID" id="119720508"/>
    <dbReference type="CTD" id="51433"/>
    <dbReference type="OMA" id="DANMGMA"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048968">
        <property type="entry name" value="Apc5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21371">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5 N-terminal" evidence="19">
        <location>
            <begin position="91"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="18">
        <location>
            <begin position="306"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="815" mass="90137" checksum="814814E494249059" modified="2023-02-22" version="1">MNFGSGNLPRPMEWVTPHKVSLAVLVTVYAEKELPEKCQPASPILVTGITGDEEKGSVTPTVAWPAIGGEGPAGPGRNPGTGGLDVTVGWSVAVKRNFARSMLKWIQSSDMEFQDLMIKVKEIDEELSKDLVETLSSINTSGLSALADFVLSLHKLLDSNNGQSPVHRHSILGIFIRRMVLSYDKLSFDQVSSLYKNLKVYLSGLDGHLTEGERSQAMMDVSTVDDGGTMTKDELDGSKPENGQVQRAGTLHLPSQRVFNRQQAESFIAQQARLLQNDDARALDPSTLQEQIAALRDSNPDLAETHFLSYLNGLRLSDFCGATDSLHSYFDHLLPRVNESNNNRDEGTSKSFRYAALNLAAMHCTFGHRDEALLALKEAIRIAHERNDNVCLQHALGWLYRLEKMNGEDVSYLLDRSITRSDALNLPYLTSLGIQNFAQHKALSSTDPASVFEYLAKSDMLNCKHNQPQLVQTSLAQQSALWQMYGHRTMSSLCDQVLLHSGSLDLPGGSANTSLITMDSEVLCLAICNQARLHGDQGMYAAAKDLIQLARDRFPAPSKHAKIWMECEQELSFSRAILQGKWQQAEQAVLNLASINESGALYRKVILLKKRGETTAAFGAVNKIVSSCKENLQGFTTELLVRALLELSELHSVSSNHTSAIPHLLEALALCQTHHLSSLYTEATARLAQTQLMLKMPHHALSLVDRIMPQVLANGSLYEQCCVKFLYAKCKVACSGQLDSDGRKAVLLSVVQLLQETADGFHKMEAEYRVKDVIYLQAHLYDKLGYTSERNKCALQFRHLDHQYPTAVAMPTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z624</accession>
    <name>A0A913Z624_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046461.1">
        <property type="nucleotide sequence ID" value="XM_038190533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z624"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190533.1">
        <property type="protein sequence ID" value="XP_038046461.1"/>
        <property type="gene ID" value="LOC119720718"/>
    </dbReference>
    <dbReference type="GeneID" id="119720718"/>
    <dbReference type="OMA" id="SAIHWIS"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="356" mass="39804" checksum="4F6EA4E4E4BEF8EE" modified="2023-02-22" version="1">MEESDDDEEMPALESIFVDLDLELVKLHPPTNTGQTQAADEETPGPCQPLTVEQSLDHGYTDSEPFTTPKGNRHEQVSILDKWPAKQLPEPPCVNKPHLGSQPLPSASEQLRFTHQQTGSARHHKTAKELAAEALAADEGGWLIFDPNLKQEANLKYQVEEFLARYPPSRVREVNGSPVNWICGKAPRGDSTTENGSDKVGLFRTWEDLLQSGRPTVTFQEIKRIAVAHRCLSGKWLVWKETGVHVDLTWERIFRATVAGQLGTSTKVSSALNDGGDNSRSHLTCVYSKDFTDKSGVLKLESRLRQLGIRCRLAYKPDVFSYLGVYRGNEWGLKPTIYTSEFDVRKNASVVISVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z664</accession>
    <name>A0A913Z664_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047203.1">
        <property type="nucleotide sequence ID" value="XM_038191275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047212.1">
        <property type="nucleotide sequence ID" value="XM_038191284.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047220.1">
        <property type="nucleotide sequence ID" value="XM_038191292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z664"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191275.1">
        <property type="protein sequence ID" value="XP_038047203.1"/>
        <property type="gene ID" value="LOC119721276"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191284.1">
        <property type="protein sequence ID" value="XP_038047212.1"/>
        <property type="gene ID" value="LOC119721276"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191292.1">
        <property type="protein sequence ID" value="XP_038047220.1"/>
        <property type="gene ID" value="LOC119721276"/>
    </dbReference>
    <dbReference type="GeneID" id="119721276"/>
    <dbReference type="CTD" id="4800"/>
    <dbReference type="OMA" id="VAHMIRV"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="41528" checksum="F5C8F0CDC4E49A1D" modified="2023-02-22" version="1">MESSVSVGLTLANTEQMTSAQNITTQAQPMQIQVAQTSQQQQTQVVQVGGSGQIMASGQPITIQLAGNQGGTVQLQQVGQMLQVTGQNGQVQQIQLVQQPQQVQLQQPQQQATATTQQQPQQQQQQQAQQITVQQQPQSQPIILQSGQQQVAGQGGGQLQLQQFVTPDGQTILYQPVTNADTSTGTSVGLPQTNQATTQNANSLMATMPVNSDGGIVMMVPGSGGVPTMQRIPLPGAELLEEEPLYVNAKQYHRILKRRQARAKLEAEGRIPKERRKYLHESRHAHAMNRVRGDGGRFNHGRSDNETSFEESPTMVPRSKFPQGENASQQQQFSVTNQAGNSDSDSSLNINLDMLSGSPQIVANNQSLLEPTPNVTTNGTTNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6G1</accession>
    <name>A0A913Z6G1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047306.1">
        <property type="nucleotide sequence ID" value="XM_038191378.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047307.1">
        <property type="nucleotide sequence ID" value="XM_038191379.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191378.1">
        <property type="protein sequence ID" value="XP_038047306.1"/>
        <property type="gene ID" value="LOC119721344"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191379.1">
        <property type="protein sequence ID" value="XP_038047307.1"/>
        <property type="gene ID" value="LOC119721344"/>
    </dbReference>
    <dbReference type="GeneID" id="119721344"/>
    <dbReference type="OMA" id="HVAMDVT"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="392"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2197" mass="241062" checksum="886771F3773640E0" modified="2023-02-22" version="1">MQENSPGRRGKARILTEEYNHSLGKLIGTKRRVKPSRKAAFMAAFPVKASPRLHSDEEGASVQSRRDASVNHSEHGETSTTEETISKAGVKSPVDVRQKLQVFVRGLLLPKTLCLQVDPETPVSDLKALVERESGIQPENQHLYIGRNFQLCDLLSIRDHGIQQDQNIKLRAGGLLGGGLLEEEPSRNIYFLNLSRELGPHWEKLAIHLRFSVSELDTFIKNYPQNSEQQSFRMLDTWWKKQDNPADAPEKLRGALKAIDRADLALQTPDIRANRKDVAETSFEVKLCARELAAHYRETMKVTTHPTERHLSREMEDIYVKPLLLHETNIPTPVSTSQTKMQLETGSQSMHSKASKRGTSDPLRSQAYMDKGIPVQKIPLDSYEDMLKLKGNRLLVIAEAGLGKTTLLKKIAYDWADLKTGDQTEKQQQPERTSVLGRYELVFVVEVNQMGETFDIIDAIFSQIITDRKLRERFEGLEKYIIENPERVLILLDGADEISFQRLKVAQCKSGISLNDVVSFKTLKSCKVIVTSRQKTANEQLLSMHEHFTKINIVGFDEEYRAKYARKYLTNFKTDDQNRFLARVNGSETLRSLAEIPLFLWLMCHTWAHEDKLPDQITSLFQDNMHLLYQHKTSKETEKQVSDTQTDVSKLGMIALEGLLDPNGEMLHFSEDKIDSKDLHIFKKGSDVGLLSKRKIFRRLETVSYFSFLHKTFQEYCAAAFLVDLSRTDESTFDQYLSRILHGDVETLEYVLIFCCGLDKIVAEKILRRIEELLRGNKMNKSLHKILMLLLFEAQSESLVKCFVETGKVDFPYELRGEVLVATHYFFEVGSKHKTLHNVDIEIVSAACLGLADFILLENIMTHIQCKPSLILELTRISLDSFVDNSTETLRYLKTLHIRYCDWNLVKLFEVLSKNNTQIMLLGTSGTISLDTVSKQNIEILPCLQQLVVFDSGLTKSDIEPLFILLSAAGSINTVVLTETDLHGLQPIEVTAVPSLSSLHLYECGLTHNDIEPLFSLLSAAGSIETLVLRGNNLHNLQPINVAVVPSLSVLHLGQCGLTKTDINALFSLLSAVGSVKKCILMANNLHGLQPAKFTAVSSLTELHLHECNLTKSDIESLFFLLSAAGSIKGLFLKGNNLHGLKSDNITNVPSLSALQLDQCGLAKSDIESLFSLLSASGSIKTLFLNGDNLQGLRPVNAKAVPSLTTIRLHQCGLTNTDIEALFSLLSAAGSIKTLFLSENGIHGLRPMNVSAVSSLSEIHFEKCGLTNTDIDPILSLLKAAGSIKKCILTANNLHGLQTEKNTAVPSLTELHLHECNLTESDIAPLFVLLSAAGSIRTVALTENNLHGLQPTKVTAVPSLSSLHLYECGLTHTDIEPLFSLLSAAGSIKKLVLIGNKLHGLRPMHVTAVLSLSVLQVEHCGLTNTDIDPFFSLLTEVGSIKKCILVANNLHGLQPAEITAVPSLTALQLNECNLTKSDIEPLFILLSAAGSIKSVTLTENNLHGLQPIGVTAVPSLSSLHLYESGLTHSDIEPLFSLLSSAGSVNTLFLRGNNLQGLRPMHVTAIPSLSVLQVEQCGLTSTDIDPFFSLLTAVGSIKECILLANNLHGLQVAKIAAVPSLRIIQLYECNLTKSDIDPLFILLSAAGSIKTVTLSGNNIHGLQPIEVTAVPSLSSLHLYECGLTHKDIKSLFSLVAAAGSIKTLFLRGNNLHRLRLMNVTAVPSLSVLQVEQCGLTNTDIDQFFSLLSAVGSVKKCILIANNLHGLQPSKVTAVPSLTELQLHECYLTKSDIEPLCILISSAGSIKTIALTGSNLQGLQSIKVTAVPSLSVLQLDQCGLANSDIDPFFSVLTSAGSIKKCVLLANNLHGLKPSKITAVSSLTELQLHECYLTKSDIDPLFILLSAAGSIKSVTLTGNNLHGLQPIKVTAVPSLSSLHIYECCLTQSDIESLFSLVSSAGSIKKLFLRGNNLHGLQPIHVTAVLSLSYLQLQQCGLTNTDIDPLFSLLSAVGSVKKCILIANNLHGLQPSKITAVPSLTELQLQECNLTASDIEPLFVLLSAAGNIMKVALTGNNLHGLQPIEVNAVPFLSELYLYKCGLTNADIEPLFSLLSSAGNTKRVVLKGNNFHGLSQVSIHPLPSLRTLDLSECGLQNSDIGEVFRLLSSLGHVVEFHLNDNSFQSNAFEALAFVPSLELVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAN4</accession>
    <name>A0A913ZAN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048679.1">
        <property type="nucleotide sequence ID" value="XM_038192751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192751.1">
        <property type="protein sequence ID" value="XP_038048679.1"/>
        <property type="gene ID" value="LOC119722565"/>
    </dbReference>
    <dbReference type="GeneID" id="119722565"/>
    <dbReference type="OMA" id="ITTHEQC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="50845" checksum="2E75EA3FFE7D6EE1" modified="2023-02-22" version="1">MWLYPANVTVYAQATASLAQLDILVCTFFTCVFQNNSDNCSVAYSLPQMDHPLIWDETGPSPWAAMNESFDAPSNERYKLLNHSLRILAFEYPAEADPFVYSNAETVMYGFVLPVLELLGILSILSFFFTICRVPSMRNITNFYLTNLAVADLMVLISITTHEQCLVFTTQHISDVSYLGNSAQAVLTLLSFTCNVGVISSIAFATLLSYDRYFAICYPFQHRNLNLKRRAIRAAVCIWVLSFFMYLIVFFYRFLAFNVPLIKCVVWPTEEKYEHLSGNVRVFGNNDVTLLTLNLVLRYVSFCVFMLSLILTVTFNILLIKGLHAPNPTGDQISGPSKHLRRVTLILGINTAVVFVCFLPQAICALIAIIMYSREEVDVTDDVAWKLDLMTACLLIMNSSINSVIFNAGSGRYRKAFKQAFCCRKRQQVPTNNIPLQTLPRADPADRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAP9</accession>
    <name>A0A913ZAP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047967.1">
        <property type="nucleotide sequence ID" value="XM_038192039.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047985.1">
        <property type="nucleotide sequence ID" value="XM_038192057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAP9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192039.1">
        <property type="protein sequence ID" value="XP_038047967.1"/>
        <property type="gene ID" value="LOC119722052"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192057.1">
        <property type="protein sequence ID" value="XP_038047985.1"/>
        <property type="gene ID" value="LOC119722065"/>
    </dbReference>
    <dbReference type="GeneID" id="119722052"/>
    <dbReference type="GeneID" id="119722065"/>
    <dbReference type="OMA" id="HSEFESG"/>
    <dbReference type="OrthoDB" id="6051114at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF227">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="30894" checksum="A68F3A76206A4210" modified="2023-02-22" version="1">MQLLTALRFFATGSFYTMHGDLHDMSAPSVSRIIHRVCRAINREANRVIKFPVRQHDVNRAQRDFFAIAGFPEVVGAVDGSHIRLYGAPLMDDEHLYVNRKGWHSINIQVICDANYLITNVVARWPGSTHDSAIIHGSVIGDMFSDGRLQGMLIGDSAYALRPWLMTPIENPITDAERNYNRCHRRTRVKVEQTFGQLKRKFPCLALGLRVSPSRTCQIIKACCVLHNLAKIMGEPDFEEEVEVEEVGALPYVGVLHDGQAHRERIIRQYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZC45</accession>
    <name>A0A913ZC45_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048625.1">
        <property type="nucleotide sequence ID" value="XM_038192697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048626.1">
        <property type="nucleotide sequence ID" value="XM_038192698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZC45"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192697.1">
        <property type="protein sequence ID" value="XP_038048625.1"/>
        <property type="gene ID" value="LOC119722527"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192698.1">
        <property type="protein sequence ID" value="XP_038048626.1"/>
        <property type="gene ID" value="LOC119722527"/>
    </dbReference>
    <dbReference type="GeneID" id="119722527"/>
    <dbReference type="OMA" id="AFRVFLH"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="14621" checksum="726066B78D3EBA2B" modified="2023-02-22" version="1">MAEGGEVRLEATTTKESAADKHRSEKRKSDTDATMTSSENLAFRIFLRENELSNALKHFPADFTLGNFRAVTEDDLADDYGIDDDNVRAQLMRAVNRAREEYDEREEAQTRRRVHSVVVNRRQSEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD53</accession>
    <name>A0A913ZD53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049712.1">
        <property type="nucleotide sequence ID" value="XM_038193784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193784.1">
        <property type="protein sequence ID" value="XP_038049712.1"/>
        <property type="gene ID" value="LOC119723221"/>
    </dbReference>
    <dbReference type="GeneID" id="119723221"/>
    <dbReference type="OMA" id="HWTIASS"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="438" mass="48529" checksum="D0E7548A0ADE4C4D" modified="2023-02-22" version="1">MENIFASNATATNGSVAEEHPFNVRYTIRLIANILVFLLGVPGNCLILRVYWIKTRKTSTDILIRALAWADLAVCFLRIAEIIYISLNLAAEYSMYSFPPGPGLSILYAVIIALADAAIVSSFSITAVIAVDRYDCVCRPQKRIFNPRRSQIVVLVTVLFAFAINVGQIAHTICLRTSCTEHASVHVYWDIGVKAEPVLFVIALVTIGVCYGKVYATIRKHVKVGPAQAPTARDAERISSDLRVGRQVNCSTRPTPPQQDIDLPTSESFVDEAVTRFVHPPSTSSSMHATSHQAKPNDVCTAAHVVSFAHQDSSGPSQPNVIPEPKAAPQDNTPSQRQSRPEPGHAPQRVGAAKLQRKTTRMLFITSVVFLLTWLPYLIYHVRFYGTSYDDVEEIIGDISIILLINSVVNPLIYGIANRRFRNDCKEVIRKIKCVKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD56</accession>
    <name>A0A913ZD56_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CUEDC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048981.1">
        <property type="nucleotide sequence ID" value="XM_038193053.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048982.1">
        <property type="nucleotide sequence ID" value="XM_038193054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048983.1">
        <property type="nucleotide sequence ID" value="XM_038193055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193053.1">
        <property type="protein sequence ID" value="XP_038048981.1"/>
        <property type="gene ID" value="LOC119722755"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193054.1">
        <property type="protein sequence ID" value="XP_038048982.1"/>
        <property type="gene ID" value="LOC119722755"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193055.1">
        <property type="protein sequence ID" value="XP_038048983.1"/>
        <property type="gene ID" value="LOC119722755"/>
    </dbReference>
    <dbReference type="GeneID" id="119722755"/>
    <dbReference type="OMA" id="CLKPQTE"/>
    <dbReference type="OrthoDB" id="10060331at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14367">
        <property type="entry name" value="CUE_CUED2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039805">
        <property type="entry name" value="CUE_CUED2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493">
        <property type="entry name" value="CUE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12493:SF0">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="246"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="41313" checksum="B27DF405E154BA97" modified="2023-02-22" version="1">MHVINPSMPRLHRKDIVTSALDSFLTMHLPQSSIGAIDDIVLNYVVGVLEDVGNDDEFDVGDFVEMMEAYIPGFKDITSATVCEWIFQLSEEVLSATYSLGTPPSSPPSVKENTTTKESVALPACPEDIELPYSPSESVNRRQENISSCSSVKKGKKTEFRFQKTVSNGPSSRNMDDKIKLLAEMFPDSCKVDVKRCLSDSNGDVEQAVQAMLQGDGYSQTCGGSLKATDKIAQGVPEASSSSLSVTDDNIQLLLEMFPGSSELQARQCLSIARGDLEQASQVLLNLQESGKLEDQSSSISLRIEKSSVRNETHVKESLLEKYGYIDTDEDRKNHRPMEPKKEKKKMVRYINSQKVTTKGRGSSRPRNQNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE76</accession>
    <name>A0A913ZE76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiamine transporter SLC35F3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049255.1">
        <property type="nucleotide sequence ID" value="XM_038193327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193327.1">
        <property type="protein sequence ID" value="XP_038049255.1"/>
        <property type="gene ID" value="LOC119722918"/>
    </dbReference>
    <dbReference type="GeneID" id="119722918"/>
    <dbReference type="OMA" id="CPWERRR"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52016" checksum="D28872BCA3B6D2DA" modified="2023-02-22" version="1">MVEVKRSNESSELHTDSGVKSADSVNNGATVVELETTFSGQANDKTDMTKGDEDDLISKQNLLDVAATSGETEAEEPTGDDGVSQSDVSPRGTSLSENVRKTIFGLLIVIGIAVSWVGATQFSQSTYTTEFSSASVNVWFSTSWMLVCYPVYILGALVFLPRSRSVEGFKNLYRDAETVFGGRGLCLRTFATLTVPFAACWAVTNYLYVYALGKIAAADVTAIFSSNTAFIYVFSWLWLHERLVLLPVRSVSVLMSIGGMVLVSYADGFKGTTALGVSFSIGAAIGSAIYKVLFKRFIGDASSGQVSLFLSVLGIFNILCLWPFIIIFYYTDVETWSFDNIPWDYLCGSAALSVAFNFLINFGIALTYPLFIALGTVVGIPLNAVVDLLFRGKNFSNFKIGGSVLVVVGFLIMLMPETLQAKAACWTEGSCPWERRRREREEMGDDTGEVNTGIDTNTIDTNETKYPETDEVKVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEX6</accession>
    <name>A0A913ZEX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050337.1">
        <property type="nucleotide sequence ID" value="XM_038194409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194409.1">
        <property type="protein sequence ID" value="XP_038050337.1"/>
        <property type="gene ID" value="LOC119723642"/>
    </dbReference>
    <dbReference type="GeneID" id="119723642"/>
    <dbReference type="OMA" id="ASAQNFM"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="446"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="681" mass="77404" checksum="7618E2E7F0B8011B" modified="2023-02-22" version="1">MASPGGNLYREVVEDGQVRVDNSQSSFGSLSQVDDTVRDLLLHPNEIGRCRENPLTEKGKRIQLAKMLLLILVPILSLAVLAGIDLHNIALNNRLNVEVRNVIRFSRDIGVLLSCLQRERDMVALFVSAISPEQDSFVTATFPQTDEALDELQDWPVKTYVLTELPYFRKKEDFKEYLADHRRNLHRSNTTVYNEIDFYTDILQIFIDWLYDSIGNSNGHGLWQTLVSYQLLIVSNVDIGIARTLGSIFFARGRFYSFDDYVWYLSKNDVGTWNFEASKRYSPLINSFYAELVTTMDENFVTTITNLRQEILNNAVDGLQPNFEAATRWFDSMTVYINILESMQSKMADEILLRLESDLDNDTSSIAVSICLVIIVIVTCPLILRAFWSLTTDIQNYALNLASQTKALNKQRKKSNWLLYSLLPKSLAADLMLKRPAAPSHYDDVTVLFCDLEGLGYICSQSSPNEVVEMMNGLYLVFDSCIDRYDVHNVETLSGTFMLASGVPNRNGTKHVTEIGGLALDIVHHINLLEVPHKPLCGFKVRIGFHTGPVVAGVVGLDIPRFCLFGDTVITASRLQTGGCAGRIHVSQASYMALLKEGGFYLMKRKDTKIGKDTKGSSIDTYWLVSRDDFKTHSTSPPYMCQYQEHKYTYEHMYVKTYTGRIQYRHGINDRLWKHPNFTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF08</accession>
    <name>A0A913ZF08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049550.1">
        <property type="nucleotide sequence ID" value="XM_038193622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193622.1">
        <property type="protein sequence ID" value="XP_038049550.1"/>
        <property type="gene ID" value="LOC119723099"/>
    </dbReference>
    <dbReference type="GeneID" id="119723099"/>
    <dbReference type="OMA" id="PEMAIDD"/>
    <dbReference type="OrthoDB" id="6063244at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558">
        <property type="entry name" value="SGNH_HYDRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="378" mass="40488" checksum="B31DAD2E8A82A8E5" modified="2023-02-22" version="1">MPKSKSKGRAASGPVDGVKRRRGRPRSSARQVPVPVPDGSASSSGVTRDTVSVASTSVPLDSVGLDSGISIDSQLATPSPIGLPGGGASPTLGLGKSVHVEFTPEPVVKSSSGPSLSVTSAPVTATIASSSFATDTTLTSVCDDLGSGVPHILQEKIWKGEFVEFGALLKSLRGSGCDDSLAKAVNFTIGSNESPAWQIRPHKQAPRITSIEQWTSAFLVFASVYLLRHPTHARQLLKYADTIRSAAFRHVGFGWRDYDIQFRLRQARLPSRSWASIDAELWLTLLGAPLVQQPNFRPYQQRDRPYASFGSPFGPGRRQVTGGQPTCHDFNRGQCIRPTCRFAHRCSACLAFGHSATRCRRNQPSRGPAVSANAGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ75</accession>
    <name>A0A913ZJ75_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Deleted in malignant brain tumors 1 protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051847.1">
        <property type="nucleotide sequence ID" value="XM_038195919.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195919.1">
        <property type="protein sequence ID" value="XP_038051847.1"/>
        <property type="gene ID" value="LOC119724730"/>
    </dbReference>
    <dbReference type="GeneID" id="119724730"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="296"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="410"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="524"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="639"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="755"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="140765" checksum="CF20D01C5EC4CAF4" modified="2023-02-22" version="1">MAGASMADTQRIRLAGAFLIILGLGVGPFVTSQTTGGIQTRLSGGDSALGGRVEVYYNGAWGTVCDDSWDIQDAHVVCRSLGYHSALSATVKYGTGSGDILLDEVSCSGDEADLSECSHNGWGVNDCEHSEDVGVYCTETGITGDIDIRLVNGNSDSSGRVEVFYGGVWGTVCDDNWDISDAKVVCQFLGFPFAVSATRRFGRGSGLILLDDVDCTGLETRLEDCGHAGWGQTDCTHREDAGVVCSTENSDESQPSEPSSASSSSYSSEGSSSEDDTEEELPPEEPDMHKQFFDDIRLSDGRAPSSGRVEVFYDGQWGTVCNTGWDLQDATVVCRYLGYPAAISADPQVTPGSGPIHLIWVGCQGNEHFLHDCYYDDGIDTSCDHTRDAGVVCSTEGLQISYPSVNETMFRLVGGASPNEGVLQIRTFNDSTWSTLCSSRSAILPGVGADICRRLGYPVFCHSQNDVAVPDSVGDSPFVRVADDECFFSSVGVLQCGLVPDVGYAQPCAANETLWISCGSDLDFRLSYGVLEGTGLLQVRCNGSQQAWNAVCGDDWLTSAHAHRAACRYLGFPESDVVAPYSLAESTLSSLIPSLVHEVVCSGEEDELNDCEITQPTLEHCTNYAGLKCSNYTETKLELKLIDSQYPASGIVVGRVRETDEWGALCGHPYDYRDSQVLCRHFGFQESVQVSRGFLNGTVPPSSTLVSTIGCFGTETELSQCEMVSDVDKSCDAYQYLECQDETTRFEAPAYLCGELHYCGYDCNQGSRDTLRHFKQNTCKCDDSCAFFDDCCYDYHSSCRTPPDGSEITINGVDLHYYACVPLTSRILSERFADFGFALVSVCPDGWVDSVVRRSCEMAAAEDDLLGSLPVYIEEGAVYKNLFCAICHGVNTRVLNTWSIDTERWDPNKLWIDPPLDGEFGSARSCPITSDRSCVGEFLNTSLEAACNDYFAPFFKSRIFYRNPHCAMCKGLHLHPSDSCGKQCTLFCSSTENWKECRSDCARAHAPPTIARLFDFEWGSDENSACEPGELYDPFLGKCRVVICASGVRDEDGACIELQAEDAELPPFPIPYQERSSFIVDDGCDALVNLDMGPDVLYWQVVQSDTQTARPTSASWFEVSIIVRRVDANVTSSEGFFAKYGNLSKALELCNVDTVTLYSTEGALLLAQFDSCVNATVEASDVFNFNISNHTERNFKIFNSLSWAKGVSTYLKNTTTPQECLDVIKLSCFQVLTLYPEEYEFQGASSIVHLSTRKEFVSREYVFSKTGKLQCAVPSTGLIPFHLPCGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLJ3</accession>
    <name>A0A913ZLJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051926.1">
        <property type="nucleotide sequence ID" value="XM_038195998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195998.1">
        <property type="protein sequence ID" value="XP_038051926.1"/>
        <property type="gene ID" value="LOC119724785"/>
    </dbReference>
    <dbReference type="GeneID" id="119724785"/>
    <dbReference type="OMA" id="ARYAYVT"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF107">
        <property type="entry name" value="E2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="417" mass="46506" checksum="C6BA7536357595F3" modified="2023-02-22" version="1">MPRGTARPTSSTTHHYKPRILITSSSNKQQQQHFSSLPCPSFDSEIPSNSYLDEVVPNWAEGFEDLLDVVDCTPDLATKGTRPTLGRPLAKRKLDLDVPTSPEVGLVNSFKTPSPRVTKKRVLKPSPKSMPRVVKSPLEKSRYDTSLGLLTKRFVGLLRGAQDGVLDLNVAAEVLKVQKRRIYDITNVLEGIKLITKKSKNNIQWKGTTNSVAAQHQQFPYHDQTAPITAASVNLHSDLADLDLRERKLDDLVHNATVQLKMLTEDPDNARYAYVTYHDIRSIESFEDQTVIAIKAPPETRLEVPDPRESIQIWLKSTRGQIEVYLCPEECSKEDSSSDTSGSPASSKGDPALKSSTVDEDDISPLNKSFLMETEDQNSTDDFDDFVPLSPPAVDDYLFALEDNEGISDLFDAYDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLS7</accession>
    <name>A0A913ZLS7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2</fullName>
            <ecNumber evidence="18">2.4.3.2</ecNumber>
            <ecNumber evidence="19">2.4.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Gal-NAc6S</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Monosialoganglioside sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">ST3Gal II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">ST3GalA.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Sialyltransferase 4B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:139596"/>
            <dbReference type="EC" id="2.4.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27938"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:88069"/>
            <dbReference type="ChEBI" id="CHEBI:90151"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:77709"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="EC" id="2.4.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:18022"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate = a globoside MSGG + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:140623"/>
            <dbReference type="ChEBI" id="CHEBI:140691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:65373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73110"/>
            <dbReference type="ChEBI" id="CHEBI:90153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48249"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="28">Homodimer; disulfide-linked. Homodimer formation occurs in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus</location>
            <location evidence="17">Golgi stack membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.2" evidence="18"/>
    <dbReference type="EC" id="2.4.3.4" evidence="19"/>
    <dbReference type="RefSeq" id="XP_038052055.1">
        <property type="nucleotide sequence ID" value="XM_038196127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLS7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196127.1">
        <property type="protein sequence ID" value="XP_038052055.1"/>
        <property type="gene ID" value="LOC119724854"/>
    </dbReference>
    <dbReference type="GeneID" id="119724854"/>
    <dbReference type="OMA" id="FAIHICD"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047288">
        <property type="term" value="F:beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23966">
        <property type="entry name" value="GT29_ST3GAL1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000002">
        <property type="entry name" value="CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051757">
        <property type="entry name" value="Beta-gal_alpha2-3_sialyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032">
        <property type="entry name" value="ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032:SF2">
        <property type="entry name" value="GAL BETA 1,3-GALNAC ALPHA-2,3-SIALYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 34" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="33">
        <location>
            <begin position="158"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00062545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00072809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00081228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="360" mass="42131" checksum="996E6D096D9E2672" modified="2023-02-22" version="1">MSFRRTFFRARYYRPLATFALAILVLVVYMNRRKIGIILSNTFEDRPHPNRDNVQEELRRLQPLKVVEEEGDLLGGAKTCKRAWQRGASPWFDKRYNETIPPLWTGRNRELTKEVRDWWLSIHEDGNRDIPALLKSLFKLIPEADPYPRRNLERCVRCAVVGNSGNLRNSKYGKLIDSHHRIIRVNYAPIKGYEEDVGTRETHRLAYPVTYTEVQKGAHFVLVPFGAKDIDWLISALTNGTIKWTYSPVPRFIEAERSKIQIYNPALMFQGKFSWIGSEERWPSTGFLMILFAFHICDEVNIFGFGASSYGAWDHYWEPDAGPWNLIYKFFLSPHKHSVEETILEKWNEEGKVKIHRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNC5</accession>
    <name>A0A913ZNC5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053236.1">
        <property type="nucleotide sequence ID" value="XM_038197308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053237.1">
        <property type="nucleotide sequence ID" value="XM_038197309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197308.1">
        <property type="protein sequence ID" value="XP_038053236.1"/>
        <property type="gene ID" value="LOC119725746"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197309.1">
        <property type="protein sequence ID" value="XP_038053237.1"/>
        <property type="gene ID" value="LOC119725746"/>
    </dbReference>
    <dbReference type="GeneID" id="119725746"/>
    <dbReference type="OMA" id="QRVFEQE"/>
    <dbReference type="OrthoDB" id="10067479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052852">
        <property type="entry name" value="SSU_Processome_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366:SF1">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="32247" checksum="D5816E96C4BBE9C1" modified="2023-02-22" version="1">MKAIKKTRLQSYNKCNDHITTASDHTSTVLSKSKRKKKNMMRKAAKLKLQGDEDLQRTKQNKQVVDFEEELRLFKEEELEKERLKMDAEQRQKGEKMKRPDPEVVVFEDPSRRRKKQVVDQDSSKSNKEEFNLKKARYEVRQFGLSGFSFEDREKCEMDRAIRLGAWAPKRENINYKEFIAIQKKKKEEDRQQREIDRKMGYSVTKKPAAEKTRVRNQGFWRDPTQDKKFFLDGQVGRYKQGVQVVSRDDISRVKTKSKKGSRRGSGKNIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRL0</accession>
    <name>A0A913ZRL0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053721.1">
        <property type="nucleotide sequence ID" value="XM_038197793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRL0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197793.1">
        <property type="protein sequence ID" value="XP_038053721.1"/>
        <property type="gene ID" value="LOC119726192"/>
    </dbReference>
    <dbReference type="GeneID" id="119726192"/>
    <dbReference type="OMA" id="WLTHTIT"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="661" mass="74149" checksum="81C438892FF89852" modified="2023-02-22" version="1">MASNVTVQSVLEKISVDHLECSICTNRFRKPKLLDCLHSFCLQCLQGLRQSQDPSGTKLTCPLCRRETMLKGSGVADLPNNFAFSALMEEVAMQEKLLEGQGSDIKCQNCDEDNRAISRCMDCDNFLCPECQKAHERMTFMKSHKIYTLTQLRSGEIVYKSKLRDEVLKCGKHPDQNLNVYCNSCEQVICTTCSVLDHTKHSLTGLPEAVKKCKKKVAEMVQKSETRTTELSTTTKAMCQSQKELDIMFANTQKKISKKAQQKITKLKQEIAKIQKEIAKIQKEEQKLLQETDMIYKDKLKAFEAVQATNRKEVTQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDKLTFMDFEEGERSLGKIILEEEPQAAAKQSPRPGRSCVKVKWELKTEFKNFELGNTQIRHVSALSDNNIVLTTWINALFTVSLTNSQHTPSPIPQRLHINGLTNDVRCIAVSKDDKLLALDCPVVKVFNKQHQLLHQFTPGRGSDSQPTCLAVDDSNLIAVGYQGKKEISLHNPDGSLIRRLPAPMIGGYLTMYNHRLIYTNYGNQRLVCVDYYGTSVFSVDMTSNMQGGWGPTGVCCDSDGSIYVAVDGYQTGDVLHYSPDGKYIGCVIKGCGHPYGMTFTSGGDLVVAAGQSVKVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUU7</accession>
    <name>A0A913ZUU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038055478.1">
        <property type="nucleotide sequence ID" value="XM_038199550.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199550.1">
        <property type="protein sequence ID" value="XP_038055478.1"/>
        <property type="gene ID" value="LOC119727597"/>
    </dbReference>
    <dbReference type="GeneID" id="119727597"/>
    <dbReference type="OMA" id="KMGNIMN"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000010">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000178">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="1812"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="1935"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="203"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="398"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="557"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="786"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1156"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1446"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1517"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="606"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1211"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1246"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1284"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1324"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1347"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1553"/>
            <end position="1565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1951" mass="215933" checksum="EE170E479338DD40" modified="2023-02-22" version="1">MDEFPSQRGKQIMSTNFNGVTDAHNPGPGGSGERKWKSYKLLIDPILKKGQQKLYRYDGVAPGPSGADFSVKIVRDPRSRLSRFWKGREKYDLPVPKFKSDKYYVGELPPKQCTITNLNDNVREAFLRNMCEKFGTVEDINICCHPKTRKHLGLASVTFSTTRAAKQAVLELNRTSVMGKIIIVQIDAGGTECERIFDCLVNSSTPSSSSSTPRDPRHGLATPDTPTPRSAGAGDPRRLSLESKTPLTSEGTPLSLPDHPFAFPEPPPVGYPMGSDQGFPVPPRPSTTPGLSGNFAGMNMQDYGGNPPGPFPQDFNRGGMEQYPPHSGNFMPPEHHGMFPRPPLEQRGLPPGFQDPNTNMPYPPQMPPLHSMPMQPGFHPGHPNTNYNMYHDSQAWDHQNYGQQGTGDGYGYSNQQQDAQLGYGNQGQPGQWEHQFNRSSSHQDFQAHKRQDSDSSYSHGSYAERDQPRDDFSDRRSKTKSRNHQRDLPASADEDSNTADSKLATERAAATAVQDKEVKPPATEEEEDEAASDTGELNMSLDSRIEALLQRQSGMGFGFELDSSLNSGQDSTSNNVGGEFSPCPSPMAGDSPLLDEGSQTTTLQESSREHSPAPHPRYDSVVSKHWETQDTSKSHKSRVDKLHLERQLGHASYKRLQHSREGSTTDGFAADDSCSRDSITSTPEIRDMDKASTIPSGASTPTVNENTSNLSIGSLINRGLSNLRNITDQVPSPAISASPFVEHQGSIDDSLGSTPVESEPQTSRLLSDTQTEKQVQIEIADALASRNLPGGSLSDMDVDDDRMSMSSISSGEDTKLEVNVPIPQPNESRTYGPPMPPPPAPPGLSSQSSARYQWPGVSLPGYSGPFSSTGPSNFSPNVGFPGFQSHHPGTNPYAIPPSVSNVPGFPAASVAPSASLPNQFINQWANMGMTPAQFGQIPTNPQHNPLEMFARLGGFPMPSFNLNQGFPAGQNPFQDQARMPGPGQTNQANQLNPPWPGALPPTPQFQQFLQQFPQQFQSPPMPNAQSEQNWYSSPPKSDPREDLISQLLKTTFIELKKTMKKDLGRKMVESSAFKSLETWWDDCERKSKEPLKVVTDNEKPSPKVQPSPLMSLSFGSRTWNIGSRPWNQGLSQGKNLGLESIGLGLGVRATMPRMPSFKLKRKVPEEEDQEKKPRAQTPQLLDEDVSDTEQEKDGKPSEKQPVRKHRKSVVSDEDEDDEEEEDDEEDDEEDEDEEEDADVKVSKEVDVEEEDEDLEEDEDEEDEDEESDSDFEDEISSLKSGSESSEDEEEEEEEEASDMSDSDESSSGSEISSSEESDSDDEAKDTSRKELKEKLAKIPEEVEEEQEAKKETEEVKEASVPKKADKKAVNGDVSQKEAVKDKAEEKKSKTKISKDLSDKTRKDAGQAESETKPSEKDQEAVQDSKPGRTTRLDSFEMLVELATKARSELLEDVPNVSGETDTSSEKNKGLPSAQEAIKKGTVEGSQDAKLPELLESIEEEVVMESVEDMEMQIGAKKATKAALPKEAADDQQPLPFLDHSYCQRPPPSPPKESPPKESPPKESPPKDIANQVLSHQPMLKLVKLDLSDQELPATPKAAAATTESEEIIDVVSDANVDVTPKKQKSGKRKHKVEPSLEEEVAVPVPSKPEFMPRNYYEEWGLLYQILAAGIDQEDSYYLRKSYESMMQEGRIPWLSYTHWVLHPLTAIPDPPKKKRKVDDVRIHGTGSGRTEGFYKITTQEKKKYLARLRTLPQDKGENNEDSSVAIKASGGKHMQLSREARSDQRRAMATLTRQDGAVSDLLKFNQLKFRKKDLKFLKSGIHGWGLYAMQPISADEMVIEYVGESIRQSVADERETRYEKIGIGSSYLFRIDADAIIDATLTGNLARFINHSCTPNCYAKIISMESQKKIVIYSKQNISTGEEITYDYKFPIEDEKIPCLCGTTQCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVI9</accession>
    <name>A0A913ZVI9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055290.1">
        <property type="nucleotide sequence ID" value="XM_038199362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVI9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199362.1">
        <property type="protein sequence ID" value="XP_038055290.1"/>
        <property type="gene ID" value="LOC119727472"/>
    </dbReference>
    <dbReference type="GeneID" id="119727472"/>
    <dbReference type="OMA" id="FIQSRNC"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="258"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50339" checksum="C1222CFE98D5B6E5" modified="2023-02-22" version="1">MSMASLFSFTSPVVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEDLEKALSRPGEASKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALDVCEYAFGKKQKEVCINPYHYKRVESPVLPPVLVPRHSESVPSHSLLPYRSLPDPPYPHNATYPQSFQQQGNQGLSPHHPGSPGGPQLSPASSSPSSPYGVPADTPPPAYMSSDDGNTNDGTPMDTSSAQPTKTNINLQDVQPVTYTEPQCWCSVAYYELNNRVGEPFHASSTSVIVDGFTDPSNKTDRFCLGLLSNVNRNSTIENTRRHISKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYRHGFHPTTVCKIPPGCSLKIFNNQEFAALLSQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLNGPLQWLDKVLTQMGSPHNAISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXT6</accession>
    <name>A0A913ZXT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056362.1">
        <property type="nucleotide sequence ID" value="XM_038200434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200434.1">
        <property type="protein sequence ID" value="XP_038056362.1"/>
        <property type="gene ID" value="LOC119728267"/>
    </dbReference>
    <dbReference type="GeneID" id="119728267"/>
    <dbReference type="OMA" id="IVFANCF"/>
    <dbReference type="OrthoDB" id="5967416at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037043581" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28342" checksum="E3CA93CC3347CB59" modified="2023-02-22" version="1">MDSGHKMWIPFTIIVFANCFVGTSGTECVVNRCPGDETCFQRNVPGQPDYVCECTRPYFHGYDCTETFNNRVLQTCYGEACATGSYTTPNYETTGYENREKILVLLYIPRATEIRFSFDPGFQIERNADELFVGRGLTVPYNDFAEGTHSALIPNLYFFDGVGAPQPFSVYNDTAFIFFESDRQSTYAGFRIFWNATVADPPQTTEAPPTEAPPTEAPPTAEDMGTTESAASAIVLQTGLLTTLLINIAVATLVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZX0</accession>
    <name>A0A913ZZX0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056999.1">
        <property type="nucleotide sequence ID" value="XM_038201071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201071.1">
        <property type="protein sequence ID" value="XP_038056999.1"/>
        <property type="gene ID" value="LOC119728725"/>
    </dbReference>
    <dbReference type="GeneID" id="119728725"/>
    <dbReference type="OMA" id="GYQRDKE"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295067" evidence="7">
        <location>
            <begin position="25"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="450"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="746" mass="78686" checksum="7C6FE1A5E3FA3D4C" modified="2023-02-22" version="1">MTAHSGTYFLTLFLLMSTSPEVLSSPVEGDVRLEGADNTALQGRVEIYHDGAWLSVCDASWDTRKGDVVCRQLGFSGGAMSTDRSALFGQGRAGSWLTDVTCTGSEDSLLECTGLTYGVGTCSHVNDAGVRCAYPMYQGCYSSSATGPLTSFSTESDAIDIALCLDICRNGGHTFAGMAKGRRCSCGNSLSGGGRQGNSGCNMACAGDMDEICGGSATASIYRTENSYSDGVNGGYETSPNFPKPYTSGDSFDNTIAIPAAFNYAVVSFSYFKLATGDSVRLQAAGATVGTYGSSDAVRDTWISMSASTSFDVSFAVGGSSPGDTGFALLYRFGKLCFPADLPSNVPYGSYNSQAQRYYYGEEVDVTCQAGYQRDKEAFVCQLDGTWSQAPACLPIPTTLPPTAPSNSTQSTTVVPGTTASETPSGDSATTAPGPVVPPISTALTTTDAQPCTVPEVANGQVDSLNRVRVLEGDMITLTCDDSYVPENDYNATCLASGEFDVALSCTPTGALPPWLIAIIVVAAVLALIVVVLIILLMLVSNEPKRNTRPGQRRTQPRDGYSAHAQRESPVEDRLVAIAPSVQQNASAASSIISGSDDGGTVNQGAQTDADPALGDIGDPMVGDSDVYHPTRDYPGAGAGRRPPSLVPMRQAPMSPPPLSATSQLPRQRSMDFRPNQADFSMLENDEMLAVRALDNVVSDFERDQAAYYLGPSGPSPYGIDRGSRYGSRQVQFSQRSRLSSFWGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A195</accession>
    <name>A0A914A195_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057602.1">
        <property type="nucleotide sequence ID" value="XM_038201674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A195"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201674.1">
        <property type="protein sequence ID" value="XP_038057602.1"/>
        <property type="gene ID" value="LOC119729147"/>
    </dbReference>
    <dbReference type="GeneID" id="119729147"/>
    <dbReference type="CTD" id="4953"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="8">
        <location>
            <begin position="283"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53797" checksum="4E42CBD26BB270E2" modified="2023-02-22" version="1">MEQIAVQDIQVEVYGRDTRIRDIVNDKVINCQDREDSDDAFFIGDLGDVVAKHRKWISSLPRVDPFYAVKCNPDRNVIKLLAGLNTSFDCASKSEIEMVLSLGVPPSRIIFANPCKQRSHLKYAAKEGVDLMTFDNEEELHKIKRVFPEARLVLRILTDDSTAQCQLGLKYGCHPKRAPYLLQVAKELQLDVVGISFHVGSGCRDVTAFADAIQSARDIFDYGERLGITMDLLDIGGGFPGQTSAAIPFEEFAHVINAALQEHFPTSSGVRVIAEPGRFYVASAFTVCVNITAKRMVARDIQTFSVPESKDLVANSVAPSQSDEPGFMYYVNDGVYGSFNCLLYDHATVEPKLLQERSKTELQYSTSIWGPSCDGLDRIVEHCLMPELQVGEWMLFEDMGAYTMCAGSEFNGFKRPVGYYVLPDNLVTLLQRLFPDNATPCYQKASLRDSATPLTGAHCAPLPAKLISLQGGAEPYLALPNEGPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1C0</accession>
    <name>A0A914A1C0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057420.1">
        <property type="nucleotide sequence ID" value="XM_038201492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1C0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201492.1">
        <property type="protein sequence ID" value="XP_038057420.1"/>
        <property type="gene ID" value="LOC119729011"/>
    </dbReference>
    <dbReference type="GeneID" id="119729011"/>
    <dbReference type="OMA" id="PAETHET"/>
    <dbReference type="OrthoDB" id="10029846at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="723" mass="80762" checksum="6CF1D320BCA97A19" modified="2023-02-22" version="1">MQARSVDSSLLAALQNIQKASGAGSSVCDEGVRYKFVPTQRNKRKLIDINAGHTYTVRKVYKNTTLWQCTMRNKNIYCRATLQQSGNKFKKGNNDHIHPGQLGVAEFTASGKVRKRRAHKKKSTRDEAISQAVTTISESFGQQRQENILEMPQFSGISTGPSGLGSEVSISQAAAEDSDDSSDDDDDTDQVQRFRPIQVQSEHLQPEMSTGSQPVHFEGTIQDGTREHVVASADGSVGPGVVSDADVIETIAEEFKEQRAPDAEYTIVDGSSQRRNAKLTDSAGYTYCLKSRNSYTSYWRCSIRNKSVMCRASVVQTGEEFRRGQFDHIHPSNPNGAVAAKLVAQVKAKASLDPDAPMSNIVGEALVETVGYYQPGLGIPKPSNLVRAAKRLRQRLSRGSDSIHDSSIPADFLQKVIERGDKSHIFLASPQQLQLLSQMTRWYIDINPKVVKSPLKELVSIHAFVADDNEPKLRPMAFLLMSRKKRKDYKAVFSALKERLPGDLAVAECILDYEPTLWRAINDVFPGVQCSGSASHWSQAIWKKIQEFGIQGSQAYVHEPTRAYKLLRKLMALCYLPADLIPRMLNKLQEKANTGTLHQLLNYVEATWIEGPTCMWSPSVWSVYAQPQRINNDVEAWNKQLNSRIKKGKLPLSVLIMHLLSESKPVTAQAKPASKRHLKRYHSTVGKNHQIVKFWEEFKQGDRKLKQLLNACVTFCLPGSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2B7</accession>
    <name>A0A914A2B7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057977.1">
        <property type="nucleotide sequence ID" value="XM_038202049.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202049.1">
        <property type="protein sequence ID" value="XP_038057977.1"/>
        <property type="gene ID" value="LOC119729482"/>
    </dbReference>
    <dbReference type="GeneID" id="119729482"/>
    <dbReference type="OMA" id="DACCTTL"/>
    <dbReference type="OrthoDB" id="263617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000004">
        <property type="entry name" value="selenocysteine insertion sequence-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="969"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1400"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1410" mass="153138" checksum="D36E702408C3092D" modified="2023-02-22" version="1">MSETDMAEGKSPQGTLLSAEVEPFIPGQSNLAKPGGRPPPTNPQPGHAPQAHGVGAGQAFTGHAHPGSFNPKMAGPAAHQNMGNPNGSGYTLTELPRYLTNCYPFVQDSVTGTGPKPEVRWPNYPSHQHPPSSLNSALPYPSPSNDVYSSQQYPVQAPNFMTQSYPQSYYPPQQSQGAIPGPVPVHQGSYHMPQHYAGYYPNYPGEGNQFPMGSYQGAGYGSYMQREAPPRQSRHSSSRDRQYPGAHSSSRDRSSSSSSLESRRYPKTLVCMDAGCQTDFPDEIANKTLAEKPSMLRRHKSKPRRRSQGNQTGQETSTSTDSETEAGTVDSDSGYYSPKHAKTNHTSVGMATHDAGTGPTAKPQGYQQYSGAVVSAVPRHITQPQPSGSPSVVYSTQNSVHAVMPQMMPPVTNFAQTQHLHHAVPPRLPQQQQQHQQQQQQHIPQHQQQLVQQPPPLGQHLPQPISYARILSQPPLPRHPVPIPNQPLNHPHVGPGLMHQQPQFPTAIENMRKNHNAATPGNRTGQPRPGTKYIPAQDGADNSPAQNAKRKKKKDRKRAGKAREGAEEPGNELPAQPPPPPPALTDMGDFPELPLGAPAGPAGGNSQGSQPRSYSAILQQQRSAPVRQQVSPEDSEPVEAVDANSADIIKPEDLLNPEAAASGIRDGKNARKRRKKAILAAQAAAKEYSEITEEQRQLQENLKKPSKKTKMPIEYDLGDMLAALEKQQQETKAKTLQQGIAGKGRPAAVPFAATPSKAQPHIEAKQPTTAAATAMVAAPKPAAPTHKEPALGHNPLDASAPAKRGKERENPVKKKPSALKRVILKEREENKRLRTLQETCLSDAEDGLSQGDDKTIDAMSGDAGLGLSQDASERGSNISPFMTSQSDLSPLSQMSPMSMSPLSPGSPLSSGLSSPATGFKSTSPAQANPSIHSRRFREYCNQVLDKDIDACCTTLLQALVRFQDRQYHKDPTKAKAKRRIVMGLREVTKHLKLKKIKCIMVSPNLERIQSKGGLDDALNRIMALSAEQNVPVVFALGRKALGRAVNKLVPVSVVGIFNYDGAEEFYKNLLDLTKNARESYTSMIRKYQQELEAAATAVPFSKHRHHLGHYRNLSGCSGISFSSVISEPISEDYPDPEPEVDSRGNEIVREVRFDDAVTTTQYTAGAPVSMLTAPEFVETGGDNTTGGYESDKGFSQEGAYSEDSGTVEQGASKTSSETLEAAELDDIEDDDVDNEDASNLSDEDQDEEDLDGIDTDFHRRNSEDEDEDEDDDEDDDNEMEDGGLAILKRKTDLPLDKGRIADWVAETQTTIQSLTLHDNDDKEDASNPIPEAKVSKPLKNSLSDRDQMPHSEHCPQSLNSCECTNKDCVQSGKSVCKSNTGNKNVDGNPSSSLDSQPSENHLDCVSKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2S1</accession>
    <name>A0A914A2S1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057899.1">
        <property type="nucleotide sequence ID" value="XM_038201971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2S1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201971.1">
        <property type="protein sequence ID" value="XP_038057899.1"/>
        <property type="gene ID" value="LOC119729346"/>
    </dbReference>
    <dbReference type="GeneID" id="119729346"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="218" mass="24843" checksum="A48067AE2EE9728A" modified="2023-02-22" version="1">MPVLYATVARGTTVLVNYAACQGNFTEVTDQILPKVPPENTKLTYSHDNYLFHYTSEDKIVYLCITDDEFERSRAFMFLREIKRKFQTTYGARAYTALPFAMNSEFSPILANEMRHYSEETPIDRLGSVQADVDDLNRIMVRNIESLSNRGERLELLIDKTENLETTSLTFRKSSKTLARSMCIKNCKLTVILVVVITLIIYFIVSAACGGLAWPHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2Y3</accession>
    <name>A0A914A2Y3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057959.1">
        <property type="nucleotide sequence ID" value="XM_038202031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2Y3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202031.1">
        <property type="protein sequence ID" value="XP_038057959.1"/>
        <property type="gene ID" value="LOC119729465"/>
    </dbReference>
    <dbReference type="GeneID" id="119729465"/>
    <dbReference type="OMA" id="VKKLHNP"/>
    <dbReference type="OrthoDB" id="10056927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036677489" description="Corticotropin-releasing factor-binding protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="12">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="13">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="342" mass="37216" checksum="945756832DAD6662" modified="2023-02-22" version="1">MTRSGVHCFSLAVLCLLKIALAAPAPERYFGFDQSAMRVFRRGEAPVKTTSSSSATEMECPYDVISQPGEYFVQSSEAMMCTWLFLTGPSAVVELEITELDYPCAEDSFVEFFDGVALQLGVFPTEAGHDLPVQERVNMVCNTGSRVLLSSQNVAMLTYQSPANGGAFRLIFKHKTIQAPCNIFSPDSSGAFTLSNFNKQKNCSFATIYPGYINVLHMAVGRETNEARLKCKGMTDMVQFAEGNSLELSKMNIEQRMCGRTGGKSPTGPEGAVPSPADALHGRDGTAASLVYKKRAQCTSGITIPLMCQMSVVRLVSSGQHDNSITFTFTRETGEKNECVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A337</accession>
    <name>A0A914A337_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING finger protein 113A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058248.1">
        <property type="nucleotide sequence ID" value="XM_038202320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A337"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202320.1">
        <property type="protein sequence ID" value="XP_038058248.1"/>
        <property type="gene ID" value="LOC119729657"/>
    </dbReference>
    <dbReference type="GeneID" id="119729657"/>
    <dbReference type="OMA" id="WQLEADH"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38667" checksum="F3BF4B405BCD5AC7" modified="2023-02-22" version="1">MADISTPAEEKEKPAFGFKKRGRLAQSRKRKTSDSDEAGSGEDNASAVIKKDRRRELSNPLKQKTKRLQERQQVDYSSDSDDATTKADKDFRVSYQSTRTAKPEGPDDRGATATVEIDTDNTVDAQTIFEKKQQINEELKGKEDDKIYRGINNYHTYIEKRDNAMGNASSGHVRKGPMRAPANLRATTRWDYAPDICKDYKETGFCGFGDSCKFMHDRSDYKFGWQLEREWDEGKFSKEEDFSKYEIDSDEDDGLPFKCFICRQSFDKPVVTKCKHYYCEKCALKHYKKSKRCFVCGTQTNGIFNVARVLIAKLEKTKQQGHDGGPSQETEEDSDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A359</accession>
    <name>A0A914A359_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="18">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="7 18">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="7 18"/>
    <dbReference type="RefSeq" id="XP_038058277.1">
        <property type="nucleotide sequence ID" value="XM_038202349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A359"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202349.1">
        <property type="protein sequence ID" value="XP_038058277.1"/>
        <property type="gene ID" value="LOC119729676"/>
    </dbReference>
    <dbReference type="GeneID" id="119729676"/>
    <dbReference type="CTD" id="8540"/>
    <dbReference type="OMA" id="GTISHQH"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000003">
        <property type="entry name" value="Alkylglycerone-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="9 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="195"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="227"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="361"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="17">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="651" mass="72520" checksum="FF4587496821908C" modified="2023-02-22" version="1">MASTERTKVILGHLKPAIGGDGVSSTGDFVCREFCSTSGVGEGIGTVKCGEETNTKSSICLQECAAVSAQTDKTPRVPKIRQEALKWNGWGYKDSRFVIGDNNEFSFSGSRYNIAGELPHFKAWIDSIEGFSPDNRSQSQDEIRSEKLPSVTRNEGFLEDVQKEGISFSFDPQDRLFRAHGHTLDEMFTLREGTFERIPDIVLWPTSHDVVCKIIELACKHDVCIIPFGGGTSVTKSLQCPVEEKRMIISLDMSQMNRILWVDEKNLTAHIEAGIMGLDLERELGNYGLCTGHEPDSMEFSSLGGWVATRASGMKKNVYGNIEDLLVHVKMVTPRGVLEKNCQVPRMSTGPDIHHVILGSEGTLGVVTEVTLRVRPLPPVRRYGSVVFPAFHQGVDFMREVAKQRCAPASIRLMDNEQFKFGQALKGPASSMWTSLMDSLKKVYVTKLKRFDPNLMVVATLLFEGNKEDVAAQEKKVYTIASDFGGLAGGEDNGQRGYNLTFAIAYLRDLGLDCYIIAESFETTVPWDRVIDLCRNVKERLYSECKRHGIQYRPLATCRVTQTYDSGACVYFYFAYMYRGLTNPIEVYEDIEAAARDEILGIGGSLSHHHGVGKLRKQWMTKAISAPGVETLRAIKKHLDPQNIFGNNCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3J1</accession>
    <name>A0A914A3J1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058403.1">
        <property type="nucleotide sequence ID" value="XM_038202475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3J1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202475.1">
        <property type="protein sequence ID" value="XP_038058403.1"/>
        <property type="gene ID" value="LOC119729749"/>
    </dbReference>
    <dbReference type="GeneID" id="119729749"/>
    <dbReference type="OMA" id="ERIVGYN"/>
    <dbReference type="OrthoDB" id="6021257at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49865" checksum="3B9E83D38E7C013D" modified="2023-02-22" version="1">MELPTTVIKRNCDGKLTNFGTLGEVSSSSNTNKAVHHWGEFVHMQCPTKSMHMVDMDLGTLTPKSLELEGPHLHQPTAHHDTLPHKSLPAELCRPDAISIHTIQLMKHNRRIRTIIAASQQLQTESNVHKGEDRGARPRLQSLPATPLMLVPTKRTWASSSDNMGQLEQHDEICKPTILNTSVQNEMFTSRKLSRRAVATICAHAGYEMSQESATETLTDVLHEYLTKVCKLLRGAVDKEALTSCTGFQDVLSQVLQEIGIGDTETLFKFWKAGIKDYHAFIQKRNSQLREQYDKLRNPGDAIVSSDSKSPRFKEEPFIDIQFPDNEQDSEIISDVPEQPNQPLNLHSLNAMELEDQSRATSGMTEEGNHWYPSAYIKTEPGTEAGSREGDGQAKELQEHSNDEAEEVIGPSHSSTSPVVDVDVTSPQAHTGHEMTLMNPRKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3Z9</accession>
    <name>A0A914A3Z9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058568.1">
        <property type="nucleotide sequence ID" value="XM_038202640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3Z9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202640.1">
        <property type="protein sequence ID" value="XP_038058568.1"/>
        <property type="gene ID" value="LOC119729847"/>
    </dbReference>
    <dbReference type="GeneID" id="119729847"/>
    <dbReference type="OrthoDB" id="10630885at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="715" mass="75827" checksum="972B6184D76D7FCB" modified="2023-02-22" version="1">MEGGNHSTDPPNDPVVTCSQLSDAMCQLEFQVNVTVRTDKNIIKVAVHAYKEESGTNMCIPPPSGIPSTCNSICWSLYGEWTTTAVTPTPVQMTVAGGSPTATTKPKVILPILIGVLVVGIGIFLAICAIFAVLCRRRRQEQSLHQGVNWDDEGYMGVSERGSPVHRSKAKGQATRVVQFTNRTYDDEIAVGVLGLSHDNRSFVPVVPPQPAMIRKTSDGYVEYNPKTDGVPAQLQEPAGNRGHGQRDRPLPNPVEEDDYVRPYEEVSEIVGAGVEVRANADNNVPRGISDRSRIRAKQQPIPPASSCGQSSGGYVDVDSLGSALQPSSTPQIPQLSSRGQSSDGYVDVDSPGAMQPVSTPEFDQSSSRGQILPASSCGPSSVGYVDVDSPGAMQPVSTPEFAQSSNRGQIHPVSSRGPSFDGYVDVDSPGSPLQPSPVIATTQILSTSSRGQFSDCYVDVDFPESPLQPSPVDANLQSDGTVDGVDVDPSDTSILSRSLHSDPCFLGRSPSSSRDDSDGFEGTDNQVDTSQLNPVSCTPSFPPQDKPSTTDYVDVDFPDSSLQPGEVSLPVAVDSGGPSLNPPDGFTDVDNLDIDKAHQSSSDGSPTAPSHAGPSQADTKPDQAIYFTLEPPTAEHTAEPDEARSSTDNNGNGSFPATSENPATRLPQAGADNPRWLTHDKDNKGGNYSQLDRGPLWKKVSARSGSAERETSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4S5</accession>
    <name>A0A914A4S5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-spanning 4-domains subfamily A member 4A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058852.1">
        <property type="nucleotide sequence ID" value="XM_038202924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4S5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202924.1">
        <property type="protein sequence ID" value="XP_038058852.1"/>
        <property type="gene ID" value="LOC119730151"/>
    </dbReference>
    <dbReference type="GeneID" id="119730151"/>
    <dbReference type="OMA" id="VAFAQII"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26263" checksum="CAB7FF7077EA3829" modified="2023-02-22" version="1">MTTYVAVTQPVGQQQLVSMQPAPVTFSTVNPQPRSGAWKGILWTGIIQVVLGSLTTILGIVTLTVFGPVFMYLDVGSPAWCGILFYVVAGILGTLSGCKKSSVVAIGYMVMSILACLAACCVIGFGAYMMAFVNSFCRPRGTFLTDLCDLKAAVNGVYGTLIILALAEFVVAIVGASMTCGPLCNGGSTTQTVIQYQAVPHVVAAPQPQGPVLYNIPTGQPQVAYPAQQVQYPQAQASPTGEQQCQDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A525</accession>
    <name>A0A914A525_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058908.1">
        <property type="nucleotide sequence ID" value="XM_038202980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A525"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202980.1">
        <property type="protein sequence ID" value="XP_038058908.1"/>
        <property type="gene ID" value="LOC119730191"/>
    </dbReference>
    <dbReference type="GeneID" id="119730191"/>
    <dbReference type="OMA" id="NARHEPH"/>
    <dbReference type="OrthoDB" id="447743at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42625" checksum="73BF03A4FBF775D4" modified="2023-02-22" version="1">MFHTKTLNLPYLPQLEQKCKINLSLSIFKNGGDPMITQNLTDSLYSRTTSDEWVGAVPKIFRSAVDKVRDLVSSDPATNPHPPSRWIKQHVRTDHDDQWESQLQDLQVQSKLLDIIVLEDESEAWKCVRYSLPSGQLAFLIRAGCDTLPSPVNLARWKVQHDTRCGLCHQPRCTLAHILSACQKALTLGHYTWRHDCVLKCIARHLAINTEKSEQELLLRVDLPGMLTEQSTIPASVCTTNLRPDIFLQCGESRGIVGELTIPNNSTTNLENAKIRKSTKYLGLVADLSEHFEDVDLVTLEVGALGHYHPHDLMAAMSILMPGTSKRTIKSLLTDIVRTVVNASYTVFSNRRVEDDWAHKPFIYYHHDKRVYEIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7G1</accession>
    <name>A0A914A7G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059725.1">
        <property type="nucleotide sequence ID" value="XM_038203797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059726.1">
        <property type="nucleotide sequence ID" value="XM_038203798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203797.1">
        <property type="protein sequence ID" value="XP_038059725.1"/>
        <property type="gene ID" value="LOC119730770"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203798.1">
        <property type="protein sequence ID" value="XP_038059726.1"/>
        <property type="gene ID" value="LOC119730770"/>
    </dbReference>
    <dbReference type="GeneID" id="119730770"/>
    <dbReference type="CTD" id="55530"/>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="108"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="560" mass="61182" checksum="25C2B04E59874329" modified="2023-02-22" version="1">MESSFCDHTEIRHDGREPVVKFRRGASNASDGGADRESYEDVDLGTGGTDGGSTGRLRRNTAELASGFGSIVGGVGEVDADALGLCEDEFTVEQAVEAIGFGWFQIKISALVGFCWMADAIEMMLLSIISPELRCLWNLERWQEALITTVVFIGMFTSSTLWGKMCDKYGRRTGLIACTTWLFYHGLLSSFAPTYVWILILRGLVGFGIGGVPQSITLYTEFLPSKTRGMCVVFTAVFWAFGTVVEVLLALIVMPTLGWHYLLLFSAFPVLIFVLSCKWLPESARYYVACGNQQKAHEILKAVALANNKPMPLGKLKIEEVPVKRGSYADLFKTKEMGITTVLLLFIWFANAFAYYGIVLMSTELFATGNTCSSEGQSQKQLECFDACKSLTTNDYVLLLWTTLAEFPGIILTFVIIEKLGRKKTMAVEFLFFAIFVFLLFICSSMTLMTVFLFAARGFISGAFQAAYVYTPEVYPTATRALGVGSCSAMARIGALLTPFVAQVMLGVSPHLAISIYGGVALVAVIACLALPVETKGREMQTVATKSKPKSATSEAGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7V6</accession>
    <name>A0A914A7V6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059868.1">
        <property type="nucleotide sequence ID" value="XM_038203940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7V6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203940.1">
        <property type="protein sequence ID" value="XP_038059868.1"/>
        <property type="gene ID" value="LOC119730876"/>
    </dbReference>
    <dbReference type="GeneID" id="119730876"/>
    <dbReference type="OMA" id="AFCCADT"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="84"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="417" mass="45902" checksum="ACB25852B6D02BBB" modified="2023-02-22" version="1">MDNGTAVNDTGDWAPVDGSMSTAINTTLDAISDVDLEQCGDFPTEDIFDLRDDEETAADYVLNEGLKNTMLPVLYTVLVVGVFANLAFFYVIARVPHMRNNTNLFLANLAVADIAFIVISVGMYVTYFSEPVRSHYGTAQHFGCIGAFVGQYITYYASIGLVTLVTAERYASVCRPLRHRSVNTRCRAIKLIIFSWIVSFLLSGVAMLRYTDLNLKCIIWPDTDTFRDLPVIAGYCLPVAPWGLLLANLTESIPFLAAFVANICMYVGIIRRLSNRSVLRTSTKEGQAASLPMKALQVRRQVSKMLIANGVVFFLCNTPLVGISLAFIVSHLRGVPLLKIYESMAGMVVISHGMLFLNSAINPFIYNVTSKHYREAFVDAFCCADTSGRPRLDSSSVAVVSGSKKPTVAERQMSNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7X9</accession>
    <name>A0A914A7X9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059909.1">
        <property type="nucleotide sequence ID" value="XM_038203981.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059910.1">
        <property type="nucleotide sequence ID" value="XM_038203982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7X9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203981.1">
        <property type="protein sequence ID" value="XP_038059909.1"/>
        <property type="gene ID" value="LOC119730918"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203982.1">
        <property type="protein sequence ID" value="XP_038059910.1"/>
        <property type="gene ID" value="LOC119730918"/>
    </dbReference>
    <dbReference type="GeneID" id="119730918"/>
    <dbReference type="OMA" id="ICSASFC"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="48331" checksum="727692C12B8E1D92" modified="2023-02-22" version="1">MAGSDASGSDARAGWFAVLAMWTRAFIWSAVIKVISMTLPLLQDQFDTTTWILGWVTSFIGTATGLFDQPVSTNKLISSSTTITSRLMGRWFRPGYVIMTCGAMIGGSVIMASFANSPAHLACVFILLLGTGFGISSVLIKEAIARCFATNYATATGIARTGDSIGLFVCAPIIQVFIDTYGWRGAMLLVGAISMHLVVCGALMMRAGAPSASRYQKLSANDGISEHPSQLPSRCTSFYKNLLEIFDIRLLSDFRYWSVAIIACCSKFAFHMWLIYFVSQAKSNGFSLQEAATFVTVGGVGGLIAKLVQGFFLDRGVMSSFHLTAIAVAICSASYCATPWLTSYWPMMTSSLLIVTSSGALCCLQDVLSKQVLGVDLLVGAFGWTAFAGAILQFSLGYLPGWLFDTTGSYTTAFVFIGSMQFLPMFPLLILRYYRCLERDARGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8J3</accession>
    <name>A0A914A8J3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059729.1">
        <property type="nucleotide sequence ID" value="XM_038203801.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203801.1">
        <property type="protein sequence ID" value="XP_038059729.1"/>
        <property type="gene ID" value="LOC119730773"/>
    </dbReference>
    <dbReference type="GeneID" id="119730773"/>
    <dbReference type="OMA" id="FVQDQFV"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037656015" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="8">
        <location>
            <begin position="43"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1562"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1609"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1643"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1670"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1785" mass="195866" checksum="985560F2EB702C49" modified="2023-02-22" version="1">MGKGQHLTASGRRFSSIITKMAPRHLISILLVSMVTVMPISSQQCPVIQGYTPIVTKPGADLTLGLMLSLHKASQDTTGGALCNFNAETGYGSLSMKAAVAATDNWPDSIQLPGLSVGLEIYDMCDTFQLAEFSAVRFANERYNDIFANGMLCANKTLHMGVVGYGFSSWSETLSTLLQPLDIPLIAYTATSDSLSDAQEYPNFFRTVAPDSGAVKALVAIMKSYNWTYSAIVHSDDSYGMSGLKAATESIREAGFCLTEPISVGIGETRDSVYDAIVDQLIQRNITVVILWVVPANLQRLFLAVERIQGAAYDISWLSGDVPLYNDFTSNPGIAKAARGLFALSPFVDVNDTYKSWFAQWYPNTDFNHPPVVNMIYAIHAYMSAFSLAHQEKCGSQQGMCEALANIQGSEFIDFIRQVNFTGIGGRAISFNENDDPANQFYDVMQFKSTGTPNAYSLQKVGEWTTDQGLTLNKDQVEFYGQGDTPVGPPTSVCMEGSCFDPSCQELTDFVIETLFSHHVAGCQSQLKLTRFKQLEAVFYAVHLINKDPNLLPDVRLSLMVNDICYSDTFAANNVGLTLVKNWDFDVGFPTQNNKYHLLGTLHSSSSSRAKGISKDLQVASIPVIDNTASSPALSDKEEFGNFLRTVSSDVKQAEAIVDLLGNLDFKYVQTINSKGAYGDDAIKAVKESAKNAGVCIANSFRVDINSDFAELVRELMAKPEAKTVVVFLFTSHARRLFQELVFMNVSAGQFQFIGSDNWGTRMDYIPGLENPAKGALTVTFKSERVPEFEEYFLDQTPNDTAYNPFFKEYWMQKFECDLPGEQPKYNQNCTGSEMLSSSDVNSLEMEYFINSVYVYAIALSNLINDTCPNGKVCDAVFDIAREEWLERLKAVDFVSQVGLMRRVSFDENGDGPARYSVYQFIEMNSVYRYDQIGSWDDVDGLSNLVDNIIDPMFLSVCTGLCLECNPPTPPDANTTSHQDYFRIPGDLDFPVVMQLSKSGDGVKCGDPKPEESLALESLLYALDKVNADPSVLPGVKLGVTVVDSCGNPAIATRKLVGLLGGFVSLESSGKPFAVLGPANPDVAEEISNIVTAPSKLPMISYSALSPNVNDDPLVLATSAPYTKEVAAIIGILEEFDWKYVGVVHSMTPYGIANSQEFQTAAQVAGICLGAQHYLNDTTDFQEIMNDFSSDDSLNVIVAFVNEEDARSLLYADHFKLSKRFVWVGTDSWDSPNLVSGLESSAKGMLLVTKERPDLPEIQDYFADSDLLDAASARNPYLRDYLQDICPSSSNCQFGNQIQESLQKLSGEISPLVNALYVAAHGANLLHDSKCGFSNDELCESFLDSSPEERADAIRRVTVESGAGGNPFSFDERSGPATYSIKNYQYDGQHGQFLIVGKWQNNDLALQIVAELAAQRGPSGCSCGPIVVAEGGDPVQVYMYVWKWIDYGIWSTVILAVSGLCGVLALLIGILFLSKRHSYVVQSASFSLSMWLLFGIILMYLLNVAFMFEANPAICGIRRFGVSFVYCVVYAALLVKSIRANRFARKQPGVDLNFAGSWSQSLLFLAFLLPEAFLVVEWLVLIPPDAIGGPLDACGTVSLPTCGITNIDLTIFMMYAYLLVLVTFLSSFGALDSSHAHHEGKSILVSSLFSILILITWACVLNLLDPEFGIPAIPIGLTADATIILVFMFMGKVDALTKKKEDMDTGLKRVKDVEMEDNLYGKDDVKKVLAMEVEDTVYENDSGKKYQDVEVEYPVFANAGATLVDEAVDEEADGDVFVEEEHTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAH7</accession>
    <name>A0A914AAH7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060389.1">
        <property type="nucleotide sequence ID" value="XM_038204461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204461.1">
        <property type="protein sequence ID" value="XP_038060389.1"/>
        <property type="gene ID" value="LOC119731314"/>
    </dbReference>
    <dbReference type="GeneID" id="119731314"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000031">
        <property type="entry name" value="Homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42924" checksum="8DB186E40320CD80" modified="2023-02-22" version="1">MFRIVDYEPKTSGAASSVMSLPFSFYGMKSLSPTQKQAGTVPSPGPVRSSENSGASSRVTAGSCTDVRPPTDPAWGSTRGEFNPATSPDSGVPRTSSNTRDALGEKPHGFDMGVSKEAELLRSGGQVDIKPQQADSMTNIQTQMQDSASAEDQAVGPADEGSGDGDAGKKRRQRRQRTHFTSQQLQELEAHFARNRYPDMSTREEISAWTNLTEARVRIWFKNRRAKWRKRERNHMNELKNGFGTQFNGLMQPFDDGLYSGYSYNNWAAKSAAAAANPLGAKSFPWSLNSVSPLAGVSNQPMCFNSQTTMSTTFPTSPVNGVMSHQNLNNSAGAAAAACPYASVPASPYVYREPCSSSIASLRLKAKQHSTSMGGFSYPVRQSPTLSACQYAGLNGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABJ7</accession>
    <name>A0A914ABJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060826.1">
        <property type="nucleotide sequence ID" value="XM_038204898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABJ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204898.1">
        <property type="protein sequence ID" value="XP_038060826.1"/>
        <property type="gene ID" value="LOC119731688"/>
    </dbReference>
    <dbReference type="GeneID" id="119731688"/>
    <dbReference type="OMA" id="KAGWYCA"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="52"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="509" mass="57640" checksum="250C0C12E916F024" modified="2023-02-22" version="1">MENISTTVEAFVATTDADNSSAVDTYFIEFSPYFVVLNTVYYVVLGPVAIIGNILSVTVSHRILRFRKSIPDMLTGCLAAVDLLCVISTHTPAVISLAEGRWVGGSPVCSYQYFMAWSCLKTSFFTIILLTVDRFLALTKPFYYRAKVTPRKMKIALACLTIFSFASTSVTIIWFSSEITLLPNWYLCMNTWGKGNQYYSYILAFYGLTFIVGVIIFNVCNTGIVCSLMRHNRRSQQMRLRVLSAAQDRRERRVAKVIETLSALFMLFWMPYLVFIVLHQTNLLYSEFAEDLAIRILFANTLLNPVIYGLFNRTYRKAYIYFVRKLLYFALCGKIKKPKVWTGRESTLSRGSAKRVKPSHERKIFFLRRSYLQHRYARKTHSHRPRGQAAGGASAEADPPMNGNPPQIIGATPLDAELDLSLGELRDFALDNIGFTLDSEEDLVGASEDDEGIFSISKREDTERRMNGWVTEPNGHLNNGTEVDAEKLTSSEGHVYSAFTNTISESTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABJ8</accession>
    <name>A0A914ABJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TASOR pseudo-PARP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061285.1">
        <property type="nucleotide sequence ID" value="XM_038205357.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205357.1">
        <property type="protein sequence ID" value="XP_038061285.1"/>
        <property type="gene ID" value="LOC119732007"/>
    </dbReference>
    <dbReference type="GeneID" id="119732007"/>
    <dbReference type="OMA" id="DIEMTPP"/>
    <dbReference type="OrthoDB" id="5960959at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022188">
        <property type="entry name" value="TASOR_DUF3715"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF11">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12509">
        <property type="entry name" value="DUF3715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR pseudo-PARP" evidence="2">
        <location>
            <begin position="419"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1888"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2098"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2625"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2833"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2989"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3075"/>
            <end position="3201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3213"/>
            <end position="3273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3377"/>
            <end position="3557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3960"/>
            <end position="3985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1966"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2002"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2015"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2066"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2107"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2125"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2164"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2208"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2232"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2258"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2359"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2446"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2561"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2629"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2848"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2998"/>
            <end position="3009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3096"/>
            <end position="3109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3119"/>
            <end position="3137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3170"/>
            <end position="3201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3222"/>
            <end position="3233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3234"/>
            <end position="3259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3260"/>
            <end position="3273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3380"/>
            <end position="3394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3395"/>
            <end position="3421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3439"/>
            <end position="3456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3479"/>
            <end position="3497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3520"/>
            <end position="3536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3537"/>
            <end position="3552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3972"/>
            <end position="3985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3999" mass="433995" checksum="597C19263C18A8D1" modified="2023-02-22" version="1">MANLFEKLNFAAAPEKVECKEEETSKSETDVVEKEKKPMHAQDQALGRSSLHDDTEDEREHVAQSVKPETAPCLSKIYLEGASGHNGSNGSNPVMPVQPEKQNGCFGRPMPDLKQLAETESRLGRNRPVSSTTKETTPSLASASSVDSKAPETLGMASSSFIPVTQKPNLAHQFVLKTSKSFVDEENVTRVPESPTSKLKATSTRDKLGDISGGEMQSSCPIDTNTTKDSVTHTTEANKSVDIEKSAEERLSVQPSATNNGLKRQFKHEIDEKPPTTAAEPVSKTGKILKKSKSVSKGDKTAAKRDHVKMKQELHSEGGHRKISKAAKRERNSGSADARAAYLPLSKPFVIPRKKAKQGLFQEVSLQSREFLKDILPIVTKQYRGKDAGNRFSFTKAQLIHNDELTKTFLEWRKEMKENEGRTEKELTESYAFINTDSKTAAEKMCQDGLFASGGHVSPLGKSNMGVYLSRYSDIIKRDGLESGYQGILLILKILKGRVKALPVNYANALEPTPNYDSHVAKSNVLDMTKLTSLQTPLAFDATQIYLFEFGDLEMSQRPRQICPYAMVNYTYQEPVKPSPAPAPAANPPTQSVPQQETRDSSVQGIPSVHHHHLHQPSMPLLSLPVSTHAKPDAPLKDQGAQDSVDKPQSAPPLTQIEALRESHYIVWEGTLTAKTEPLCSAKMVSYTSPVLPQNLPAIINFKTKISFAKMHTYFPSGIFASGIPLTSNIREVCRRNKYVVYCELQRNKESTKRYTNLLQFTMLNQVVLKCRLEGNVTMFVLPTSTLSHELGVTRGDYPETLHVLFTSHSPMIGHITEKGVYMPPGNLIQSPVPDNQLLEHSNNKQLMLRIGLLSMFTRQSHDLKRQAEIKSPESVSQETLVQGASDPQTPLAVDRTNTVDSKSKVIDYQHGLLSKDRPTPPGALERSPLPSEVLNIHPMYKSPASTVDIQKDTVPEASLHPMYNIAETLPQAAVTPKEGMSKKHPHPVCSPQAQLQSPYASDASQEENVHPMYSQHLEPNREDQKSPRAALLDPRLAKKQPLGPNRSPGTSNSEIQREPPKVSRSKLPLGSILDQQSEITRLQEEMRVLRRLKDTSAGDQALEERYNAKLTKLQDFLQALRKERNRLNQQQEVKQDQTQTKEGAMRGQAAGDLQAGEDKVQGKPDVFSTPEAKAFKPYTIQSSPLASEMSKDLQESSVSPALSSKVMDVVQQIAKLPVKPAQTNPEVSIETLKAVIEKVLVTPSTGKTGGEGTPRSVSTFPVSIPLNMLSLSKPSGDQRSIKESGDAEAVERACGEVSQNTESEGGSNSLEEGKVKPPPNPFGEALSSMDHYSQTERASKKLKRSHSKESVEMGELERKMESGDMPTQKADGKPLSFTDKYNKESLSLDIDLAKKALPNLESKAGDMSSPIRGASEMKAFLNGGVAVAKDRITSATDMKSYLNKKLQEAKNEKPDRARKGGAGSAAPKRGKVSGSSKERTIAEIDNEIRRLNKEKERLKTQYARKRNSSGGSNPDKPKKLPFIQSVDLKGLGRIPKKKTPSPETVEGTSSTFSDLSETSAEKTRPSVGSASTDVHSHGTSEGRSSQPVGVGLGAPESIPGIPNCPIDKSTFKVCAKEMQLSGGKEKELFVSGQDGYGRTLYMIALTRKFLQGGMKEEEWSGTGLQHCVNDILHRGSRCDSAVETEEERFFSQNALAAARTVFTKQLAVDQTIRQVTEDYQQTVTFNSDKEFTTKPESLSDAKGDSRPALDHMTDYEASKGLAESSEEILYDEDMDLVAPEETVIELPNQEFVMDKQVSPTEKPRGTDEVDVPQEGPEAISGSLSTNLPGATTIPGLDIDQKPQESRELDRTDKPSSKDALVINDGACFFGDLESEEGVCVNFGLEEGSLADEKSPPDPTPDLHPPIDDSPMSPEQKDSEGINVKLASTAEENIESSDRLLNEKAFPLASPTSPEPEMSKTDLLEQSKTLPETVLSNDSTDTTQTVEAVDRDKSLVKDASHSTDLMSEAITSNTKPDEQSKADDCPVVEVSTCDSTTDEQSLKPSLKSDSSMKDSRSSHRHHPYERRRDQDEEEGRKYSKHLAVPELHRLMQNYTLAAYKNRRRNRHTAEAKPDFYDSPRSSPARFRDVSREFSRGKAEKSKEGKQDVKTLAEKQQKKKTQLQELEKEFVKEPGKPTGRGDMTEESYQVEKCYYEDQVEAGRHERSTQGRVPSSNRQASTSSTHHAPVQGEVSQPSSVTSPTTRTCQITTGGGATIASIDTQASFLPSRSNSSTYSSSGSSTSSRSNRCSSSANSCSLGSSSNSQINSSSGSSNSSNGRCSYSSNSNSSSDNRSCNSSNSGSSSAGTSSRLVGVGGGSPKNQFTEGGGNQSQHIPSAANQDLQSQPPLPDHTKTTMDNRTGLPAGLVPISHFYPVQTQPVVTKKESCLVSFSINAARDPRIRRQHNQQPLTTPQTEPIKTSEQTIVNSSANNTTPLTQKESKNNAPVVTQNSPGASVSSIKPPNLSNRPAKSILKGGAQRPPSPVTVDRETRSSSPSCEQVSDASSDASKKVKISLSQYKGKADPREKTASDEVEGCRQEEQPKSSVMHEAQPDAQSRQVVLLPAHENIKVTVTGDSERSLVLEETQTNEDKPGSNKVDFDDTHWNRRDAHETGETSVDYALLSEEPFLKSKISNDTDLRVVVDHAGSDETPQSLSLSSALSSNASNILASQPNLVITVPRDDTREVIPSGPTEDGVSHDRQLTVDEGDARAAEPPEMSLETLITIAQLELEDSIFNIAADAVENTTSEQTNIKEHLNKLSPNSVYRRLQSVKYELDAFWSELRKLNLPDPLRIDEAAPTDPRRNRKQLQNGELNGKDLTTQTTNDVLSDITSKLTACLRSPRLPNEEQIKVSSCVSKHLPKLAKLAKMTGPQINGKSPKKPLKKCSPVDEMISGLQEDFHRRVEDVCLSAVEHSRPKQKEAKAESESLVFSSNTDLLSRIQQMLTTARAQACKAKGNSREPNSRRPDESGASDRTCKNPTPPEPETNHNQNNNLSEMSSEDKLKREIEIAELVQERLPSPLPSKMEPDIMPKVVEKENEVQHIPKKKKLTETARSPSSPEMKSASSSPHATPDSGKWGKFKMKLWGKRPTKQRKTMKATWVKVEKPKASPEEASAEMSSTQADLETTSDDAKDVDIKEDTSDVKTDESKEHKLSSSEERAVEELCAKLLGDDKASRKKETSGTGTIPTLLNRTTSHASSISKGSSTSITSSKTASGSTWQKSQLKQGFASQPAQYQHPYNQQGHMQHGMNTMNAQSQGFQVTAPYNSNGAAYQGYFQQHPSNPSMQQQQQNSAGYMQQHVPTSFPTGSQQNPNSVQQQYAGYGYGIASVQGPVNMGPASSSSGPWSNSVTSVSANTGPGLSNTGPGTTNIGPSQTNNGPGSTIIGPGSNNPGPGPVITGSNNSGLGQYSMGNGPNTMGPRPNAMMPGPNTMIRVPGHNTMGPTPNTVGPGPNTMGPSPNTVGPGPNTMIPGPNTVGPTPNIVGPGPNIVGPGPNNMASGPNNMGTVPNNMDNGPANMMPGPTNMGPGQNNMGAGANYYGAGLYSSGPNNMGYGPNNMAPGSNNMGPGVNCMGVGPNMGTGPNMGPGPNMGPGPNMGPGPNGMAPGAYTMGPGACNMGPRLNLQIRQQPPVPGLDSEGRHSYSTLNTNAASYTYSLSNFHVYHSQVYFSTQLMSTYPVDLTSVSAPAVDVTDKTNREIPNKTDIAPTANSVAKSKTSIAEDLITEDSVFAGVKVRLTGIDKDLMTDTIQGKSFEADVSQGDSKLTKQPESVDSMAVLNLDGLQEAEQDIPSGVLTPVPSSPLKPGMFEATNGCRRESPGNLFEPAEGAMVGTQINPLDNLKLSESQACIPQLSESCVTDQANSNSVWFSELKDIKKGFLPNVSETDKGKQTYLDNVSMLEQQQDDVSSETVSKTLDGVLDGRGTFSVSQNGRRNEEQGENDKLPKESKSFLLGVLNMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABN8</accession>
    <name>A0A914ABN8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038060769.1">
        <property type="nucleotide sequence ID" value="XM_038204841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABN8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204841.1">
        <property type="protein sequence ID" value="XP_038060769.1"/>
        <property type="gene ID" value="LOC119731641"/>
    </dbReference>
    <dbReference type="GeneID" id="119731641"/>
    <dbReference type="OMA" id="ISEPYGF"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="43576" checksum="F853C2187E1256C6" modified="2023-02-22" version="1">MGVCGLYNSKLSLLICIFCLIVFCVLTWTKMEDPTSFKPRQINDQHRVDFGVRVTPSQSGTPLDGGPTQQQNDFQKRRESQNAGQKEQGNGEISEPYGFMEQQAVVQSERRRHLREVCSNHPELSQGSINAITLRNLFVQHKSKIIFCAVPKNGCSNWKRVAMVLGGVYNQTEDIPLREAHMDTGLKRLIQLSPAERNRTLQTYTKFMYARQPFLRLLSAYLDKFEGKAASRQGQYLRDIAKGIMRRYRKNATTRDLQTGENITWYEWMTYLTNQTERADFDPHWLEIHKLCSPCQINYDYMGKLETVDDDARYMLTSLEVQDKVNFPTGDEHQTNSSQAYSTYFGRVTMASLQRLWEVYKLDFELFGYDNPSPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADC7</accession>
    <name>A0A914ADC7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061743.1">
        <property type="nucleotide sequence ID" value="XM_038205815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205815.1">
        <property type="protein sequence ID" value="XP_038061743.1"/>
        <property type="gene ID" value="LOC119732357"/>
    </dbReference>
    <dbReference type="GeneID" id="119732357"/>
    <dbReference type="OMA" id="FTTVTHI"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="229" mass="23095" checksum="842770ACA92087AC" modified="2023-02-22" version="1">MQTQPQTKPRIRQGPSPSHSLSSPSPSSPSSCSRSHRHSPSHSHSHKPSCRRILGPCLSPAKTPTPAPATDRDQATDPAPAPAPAPAPAPAPAPALAQSETQPQPPVPVRDPAPTLDRATDQATNPATNPARTQAPALVPTTDPAPDTAIDQVPVPAPAPAVQVPATAPEAPAPAATVPVSATDLAADPDSAPASAPAQTPTPAPAPATDRDQATDPAPAPVYSFMKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEC8</accession>
    <name>A0A914AEC8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061714.1">
        <property type="nucleotide sequence ID" value="XM_038205786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205786.1">
        <property type="protein sequence ID" value="XP_038061714.1"/>
        <property type="gene ID" value="LOC119732327"/>
    </dbReference>
    <dbReference type="GeneID" id="119732327"/>
    <dbReference type="OMA" id="WLETERN"/>
    <dbReference type="OrthoDB" id="2371919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="470" mass="53502" checksum="4F9BFDB19D5C9F8D" modified="2023-02-22" version="1">MSEDCKDNFNLTTTADLLQRLGFIIKHDKSQFVPSHQLTYLGFLINSSTMTLSLLTEKVHKIMTHCRDVLQAKDLTVRDLAKLIGRLSSSIQAVFPAPLFYRSLQQDKGIARHRENSYETEVILSPASRTELETWISCIRLWNSQTLLNPTPDLMIQTDASLWGWGACLGKVQCGGRWSLQEQSLHINNLELHVLAVFYALKSLVSQQRNIHIRVQVDNMTALSYINHKDGTHSHVLSSLAVQRWTWCLAKHLTLSAEYLPGVQNTVADNLSRVFSDRTEWQLLPGVFQEVTQMMGFCPSVDLFASRLNTHLPRFVSWLPDLLAWRVDAFTINWKNLEGYLFPSFALLAKCLQKIFVEKALVLLIAPVWKTQPWYPRLLELAVETPVLFPRQLDRFRPCHNGQYHAMRKTLQLAAWKLSGDPCQQEVFRSKCPPSSYHHGAVAPTPSLIQLGTDGTTGVFDGNLILFEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF89</accession>
    <name>A0A914AF89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038062383.1">
        <property type="nucleotide sequence ID" value="XM_038206455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206455.1">
        <property type="protein sequence ID" value="XP_038062383.1"/>
        <property type="gene ID" value="LOC119732852"/>
    </dbReference>
    <dbReference type="GeneID" id="119732852"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="241"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="547" mass="61497" checksum="ED4C928D3698DCDD" modified="2023-02-22" version="1">MKPLALASTLTTSKKRIADRLDDHIPVSQAPYQHGRGTTEQVFALMISAEKAITADSYELHPLLLDMSKAFDSPKKVTNKELYRRTNEIPWSTAITRRRLSWTGHLLRKSEETPAEQALLEAIRKNKLPRGGQRTTLLKRVNKDLTTTGVNIKDRHTWHVASDREQNDVVSQGADSELPPLPVTDQSSPGLDPDHPDDIPLEPIASAVVCESISNEDSVEASNDVAYGNVGPKLSFSRDLVVIKNELGRGEFGRVLLGKALGIVEAGKETKVAVKTVKEGADRHAKNELLAELQVMKTVGSHPNVVKLLGFCAEKDPIYVIVEYLAKGDLKSVLMEYRDKDPGTGYANVPGLSKSLSRTLIKFARDVANGMAYISSQKFVHRDLAARNVLVGEDMVCKVSDFGLARDVMNTRIYHRKSQCPLPIRWMALECIVHDVYTTKSDVWSFGILLWEIVTLGARPYPLMTPTTMINVLQRGYRMPRPRQCKKKLYKMMRSCWQEIPKDRPSFQSLYWQFADMASKDEDYLTMKNLDERIYKVKGADGMNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG86</accession>
    <name>A0A914AG86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062732.1">
        <property type="nucleotide sequence ID" value="XM_038206804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206804.1">
        <property type="protein sequence ID" value="XP_038062732.1"/>
        <property type="gene ID" value="LOC119733216"/>
    </dbReference>
    <dbReference type="GeneID" id="119733216"/>
    <dbReference type="OMA" id="ASKEVMY"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="37678" checksum="4F8A55E6CA923DC1" modified="2023-02-22" version="1">MIDQNLKMADHTGENVGEVVQTSPQKSNVDSETVKRTKEEDETNAELDDLLDSALKDFEKPKAVAADQELPDGKTEAVAGSSKTQAASQEAPPLPPGQEALFNQLFAGGDGATDFESVMSSVMSELGKDLGQDPGMNDDLLAKLLQGGGAEAFPGFGSAPPTEGATTSGNETLESTLGDTINRLVQSAQDLKDGNVPEEEVLRQMENMHLGDGSEGEMMPMMQHMMQSLLSKDILYPSLKEVVEKYPVWLDENQSTVKPEDFERYTQQFELMKRLCTEYESEQSTDSTDVKQQRMTRIMDLIQEMEGLGQPPTDIVGEGGTGLGLQFDGQGMPKIPGMPQGDQCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH07</accession>
    <name>A0A914AH07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063002.1">
        <property type="nucleotide sequence ID" value="XM_038207074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207074.1">
        <property type="protein sequence ID" value="XP_038063002.1"/>
        <property type="gene ID" value="LOC119733684"/>
    </dbReference>
    <dbReference type="GeneID" id="119733684"/>
    <dbReference type="OMA" id="HILRRIM"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF27">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="344" mass="37722" checksum="CFEAFB3262EA7C25" modified="2023-02-22" version="1">MQMEELKLADQNGNYTTTWKIIHTLSGKNSKLKVKVKKRDGSAPASDQELLEEWKDYFSSLLNNPGLSTPQLPPPAAEDLPIFIDPPPPTREETAEAIAAMKVNKAAALDCAITAEALQGGGVIPSMPSVLKSTQPYLHHIKPRLRSNQAGFRSGCSCAQQIHILRRIMEGFKEYQLPLTVTFIDFKKAFDSINRTVMFAVLRHYGIPEPLVNAFQVLYNSSSAVMVDGSISDLFQVSTGVLQGDVLAPFLFIIIVDYLLKAASSTEDSGVVTHPHRSRRHQAKMLNDLDFADIIALLESSTSRAQSQLSRTATAAADLGLTISVTKTEYMSQNLKFTAVPSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH27</accession>
    <name>A0A914AH27_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062821.1">
        <property type="nucleotide sequence ID" value="XM_038206893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062822.1">
        <property type="nucleotide sequence ID" value="XM_038206894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206893.1">
        <property type="protein sequence ID" value="XP_038062821.1"/>
        <property type="gene ID" value="LOC119733295"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206894.1">
        <property type="protein sequence ID" value="XP_038062822.1"/>
        <property type="gene ID" value="LOC119733295"/>
    </dbReference>
    <dbReference type="GeneID" id="119733295"/>
    <dbReference type="OMA" id="NCHHIND"/>
    <dbReference type="OrthoDB" id="10055694at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043407">
        <property type="entry name" value="Nkap_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940:SF1">
        <property type="entry name" value="NKAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940">
        <property type="entry name" value="NKAP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15692">
        <property type="entry name" value="NKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="378" mass="45720" checksum="070177E9F5EC8BCB" modified="2023-02-22" version="1">MATVRYLDRKLLRNIIRHTETHNRLQEEDEMWRGKAQEAFGWRDRPFSSRRRRGRKLNRERFDGQMDRLQRMNPDTRSPQDRWNWNGERNRDIYRTELGNHERWGHTGFMELYPEEFINKDSMDEMSNEEDKEDKRRKKMKRKHKRKRESQWELSSNKRHKGTESWSSSSESDISSASSDEQQVKTSAARKRTHRSQHREQSEHRRKHRRVPSIDGSASRINQHPKVKDDTSYHKRAPFRSPEKSNQRLRHSDKMEGGKKRASVDRKRERRHKDEKVNGHRSKDRIHTSPDSQKTRGVDNGQHRKRTVDGEMEHKQDQDETREKRRRKELTKASSSSRAERRDRSEEQDHSSSHRHKSSRKAKKRHQGEKDTKHARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHK7</accession>
    <name>A0A914AHK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062864.1">
        <property type="nucleotide sequence ID" value="XM_038206936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206936.1">
        <property type="protein sequence ID" value="XP_038062864.1"/>
        <property type="gene ID" value="LOC119733352"/>
    </dbReference>
    <dbReference type="GeneID" id="119733352"/>
    <dbReference type="OMA" id="SCLCTEI"/>
    <dbReference type="OrthoDB" id="545063at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF6">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="4">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="330" mass="37563" checksum="94234EC659EB9F69" modified="2023-02-22" version="1">MATGVQNDLMKQAQHFWSMLDELAETDEDAYKKFMATNLQRGQQELTPAKPWKCVKTQILKPDKSTLYINICSWSRIDKPKTSTEPIKVTAGPVEDRNDETGDFKVIRVAFNPDVLEECAKRSVEQDMLIGNAIDYLKDEKKLHLSSNYRICHDIQFKGDPKDLKDFFNSRAKSKQKVEPDRSTENLSKLTPDSLLSQLRVSNDQSETTVSSTDTTLELNGKTSELKTALIQEISSNDVRLKCPEYDVSLKEADEKRPRRLMVRIMLPDVHSVADCQLDIAKEELTLLVTDKYELRLPLPEIIQDDDSTAKFNRKTSSLTISMPTRTVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHN1</accession>
    <name>A0A914AHN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063188.1">
        <property type="nucleotide sequence ID" value="XM_038207260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207260.1">
        <property type="protein sequence ID" value="XP_038063188.1"/>
        <property type="gene ID" value="LOC119733896"/>
    </dbReference>
    <dbReference type="GeneID" id="119733896"/>
    <dbReference type="OrthoDB" id="6619140at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="235" mass="26643" checksum="F4A2EF4335CF166A" modified="2023-02-22" version="1">MRKSPPKKTPRDLDEAATVECPTCHDVFLHKRSLERHIKVEHGPQEYYWCGQCEHRNNRRDNLRAHYRDCHPSAQGEVSQIRAETYESRERARRSKIEESGHRSHENHPTTAERDNEARRGAETKSGSSGRGSDHPEAGNNERKRSRATDAGDKPSKKRLRGESAPATVSRAPNERQVEEERPATRARRVKAPSTISRAPDDEAMELSSSEKAKEKAESPTQVVVSVAAEKNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI31</accession>
    <name>A0A914AI31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063049.1">
        <property type="nucleotide sequence ID" value="XM_038207121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207121.1">
        <property type="protein sequence ID" value="XP_038063049.1"/>
        <property type="gene ID" value="LOC119733742"/>
    </dbReference>
    <dbReference type="GeneID" id="119733742"/>
    <dbReference type="OMA" id="PRMIRPK"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="7">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19192" checksum="8200975110413FE5" modified="2023-02-22" version="1">MISNSGLQSFQIIIVIISVIASPSRPEYLIPRPQEKYVEVYCQFSNGFIASCVYNLLLILVCCYYAFKTRKVPSNYNESKFIAVSVYSTLVLCLAAVPVYTTAVAVLQKVATLCMVLLLNAYLTLVCVYLPKLYAARFVKDIRVMDWSSSVQDSRIKPASTMSTGAEQPATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ83</accession>
    <name>A0A914AJ83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063698.1">
        <property type="nucleotide sequence ID" value="XM_038207770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207770.1">
        <property type="protein sequence ID" value="XP_038063698.1"/>
        <property type="gene ID" value="LOC119734330"/>
    </dbReference>
    <dbReference type="GeneID" id="119734330"/>
    <dbReference type="OrthoDB" id="5693at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001497">
        <property type="entry name" value="Zinc finger protein 275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="524" mass="60247" checksum="62911BE8F1CD67C2" modified="2023-02-22" version="1">MSAIKETTTKTDDEPEVEPYCHDTRGKAICEKKLEYRRRSSAEEDGFVCDICGEGFSERGHLQVHQIPVICDICGKSFSRRCLLQEHETVHKSEKLFLCGICGEAFSERSLLHEHERVYSHQELFLCDNCGEGFSKRSLLGEHQMPVICDICGTGFSKRCLLQEHEMVHKSEQLFLCGICGEGFSERGHLQVHQIPVTCGICGKSFSRRCLLQEHQTVHENRELFLCGICGEAFSERSLLHEHERVYSHQELFLCDNCGEGFSKRSLLGEHQMPVICDICGTGFSKRCLLQEHETVHKSEKLFLCGICGEASSERSLLHEHERGHNNEEMFLCDICGRGFSKRSLLQEHQKVHNDEESFLCETCGRGFARRCHLQQHQKAHTNEKSFVCDICGRSFAEGFNLRQHYQRVHPKEKPFVCDICSRGFSDGYDYLRHQRIHTNEKPFLCDICGTGFQRKSHLELHRVLHTKEKPFLCDICGRAFSRQCSLQRHRGLHTNAKPFACDICGKGFSRSCYLQRHQSVHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJZ1</accession>
    <name>A0A914AJZ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064300.1">
        <property type="nucleotide sequence ID" value="XM_038208372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208372.1">
        <property type="protein sequence ID" value="XP_038064300.1"/>
        <property type="gene ID" value="LOC119734805"/>
    </dbReference>
    <dbReference type="GeneID" id="119734805"/>
    <dbReference type="CTD" id="51061"/>
    <dbReference type="OMA" id="VIYLYHQ"/>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052792">
        <property type="entry name" value="Thioredoxin_dom-contain_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46497:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="671"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="801" mass="89766" checksum="4F86BB81D60D3F3B" modified="2023-02-22" version="1">MLADVPSEATNYDYEERLSSAIAAARATDPGRPASGAPAPTYPSLQHVNVAAVLLRAMAKALRKNPEFLSLLFVAFLFVVVSKYAQNSGASQSPAVPPPIFPKDSPVFEFNNGDMQSAMSRIQREENEFSFVMYYAHWDGNSRDIAVEFDKAARQFSRWVTFVAVNCWWLHGSCRSRVKTTMYPALLATAPSIPSGLQYTGILQAPEMVSFLHQLCRPFTYVTDMEALYKLHALQGTVVVGYFDWSNFPLPPGLASFQKAAWLALEKDVIEPVAFAVVTNIRLAKRLGLQQPKSVAIIRALNSTLLYPRDARFQAKMITEWAYKHRESVVQWLAPAGVKSTIMASQLNNSPAVVLFTRHHPRQGLLNDFYMFKKIALDYYNCNNSRLVGKIISAIDDARNPNLNPEDCHDADHPSDDVPNACECCQTLADTPITTTATHGRNVCQVCEQSTAHRPSFSCNPVLPRSQATWMNMIFQGKASLAPNSCLRMNYNYSPYSQLQLCCRQCDATPCHLNEQSERCAFRDSYFGRPSTDSACYGAPGRTDCSSRCQEPFQRTRASSTKTKQKNPCQRTPESLKGVFHPFLGQFTGLGCRTNRTVNFFAMRSEYFWLFAKQLGVSDTSGFQTQQRRTAVVLLDIEAEQQHALLQEVSETAIINFVFNYTTSNLTRHLRSANHTTPSRCSQTSSVCVQEVVSSTFEELVLDSNKDVLLLYYAPWCGFCARMHHIYLSLARVFQNSSNLLIARIDGDANDLPWHLTPSSYPTLLLFPAGHKEQSLQFPQSAKLNLPNIIKFVLQHATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKV8</accession>
    <name>A0A914AKV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064362.1">
        <property type="nucleotide sequence ID" value="XM_038208434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208434.1">
        <property type="protein sequence ID" value="XP_038064362.1"/>
        <property type="gene ID" value="LOC119734850"/>
    </dbReference>
    <dbReference type="GeneID" id="119734850"/>
    <dbReference type="OMA" id="MNTHISY"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="324" mass="37191" checksum="B83C1B2255D2BE3C" modified="2023-02-22" version="1">MTSTLLTFGCLVTISSEEIERYCSKLKPVDLGTWEVHDYEGVALFLDNLPSTLHDLKTLEIRQDDVFVVTYPKAGTTWTQEMLSCILHDGDLETVNKTHTMRRVPFLEMSFGGTVHTDSPRPHKIIGNHPRSSPRLIKSHLPGQLLPPQVWEKKVKIVYVIRNPKDIATSYFHHMQLTNPHLDIQWDDFFERFSSGMIAYGKWWEHFLYFWERRNEEHICFLRFEDIKKDPRGTVKKLSEFLGKSFPDDVIDAITDHCSFANMKKNPMTNPDSLFVMVLGKQEGRSFMRKGAVGDSKTHLSESEAAAIDAVCKEKLAPAGLTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMS2</accession>
    <name>A0A914AMS2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064734.1">
        <property type="nucleotide sequence ID" value="XM_038208806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208806.1">
        <property type="protein sequence ID" value="XP_038064734.1"/>
        <property type="gene ID" value="LOC119735105"/>
    </dbReference>
    <dbReference type="GeneID" id="119735105"/>
    <dbReference type="OrthoDB" id="6141723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22755">
        <property type="entry name" value="OTU_CeDUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="4">
        <location>
            <begin position="197"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="79010" checksum="C1367A12F4C8C49D" modified="2023-02-22" version="1">MECHSCHKTYKGAKTLQNHKCTWCSDCNRIYSSYQRLQHHKCNPHTSSKTPHVSYAAAVKSQGSNPRKLPTTAVDSFSSQSTHPDDQSQLSQQISTHPDDQSQLSQQISTHPDDQSQLSQQITTGTKHVSSPLAKHTINHDSQTQLESVSFQGRSQRSFAFHRIDVGLQMRLCQQLSLPLVSILPECNLAHSAGKPASIAPIIGDGNCFFRTLSYLVTGSERFHGELRSLVVSHMNVIRMPVEKFCFDERTSLPVYLARSNMSQDGSWATDVEIFTAAHLLGTDIYIYSAGNNNTANPRWHKFTGKMLDRNAQVSDRSFYIHHKNGNHYEAVLSVHQSGETSLMEMRTENNTTEFTWLVREFNQQQQFASKKKQVSVKCQSSTQIAKHRFSQTPTTTETLKTTEKQSTNQDRLPSESSQTVQMEKSKMELKREKDRLRKQLRRKDPEFRKKEAVWESNCKKKRRDVSEIRDGEKAKELESVHRRRSNPDYRSKEKEKELESIQRRRSNPDYRSKEKEKELESVHRRRSNPDYRSKEKEKELESIQRRRSNPDYRSKEKEKELESIQRRRSNPDYRTALPRSFQDTETIQLKLMRRLKYKTPYHYETVRPKKIFDAAEWLVKNSPIYQDENIQLDMAWKNQEWNDTTTVNFIAKHDDLDMNVDTQVGNIEASLDDDDDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN83</accession>
    <name>A0A914AN83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065212.1">
        <property type="nucleotide sequence ID" value="XM_038209284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209284.1">
        <property type="protein sequence ID" value="XP_038065212.1"/>
        <property type="gene ID" value="LOC119735549"/>
    </dbReference>
    <dbReference type="GeneID" id="119735549"/>
    <dbReference type="OMA" id="ESCMFNA"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000004">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="306"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="516"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="702" mass="78934" checksum="AD6EAA723C2BAFCD" modified="2023-02-22" version="1">MSYSFSDKAGSSLPRDDDEDDDNTLKIMVATDCHVGYAEKDGIRHSDSLNTFEEILQQAKKNKVDMILLGGDLFHENKPSRKALHGVMALIRKYCMGDRPVQIQFLSDQSLNFAANPFPVVNYEDPNINVEIPVFSIHGNHDDPAGLGNLCALDILSVSGLVNYFGKCNSLESIDVTPLLIQKGSTRLSLYGIGSIRDERMHRIFVSRKIRFYQPKDEDNPWFHLLVLHQNRTKHGETNYIPEQFLPDFLDLVLWGHEHECKIDPAWNDRQHFFVSQPGSSIATSLCQGESVQKHICLLKVRGKALKCTKIRLETVRPFYMRDICLQDTDLNPGHAGIKDKVEAYCSERVEGLISLAEDEHTGNPKQPLLPLIRLRVDYSGGFETFNVNRFGQKFVNRVANTKDIILFHRRKLQPEKRDVKPSQDMANYLRPDALDAGRVEDLVKQYFSDADEHKQLNLLSEKGLGQAIQEYVDKEERDAIAELVKFQLEGTQGHLKNRKTSDTFILEELKHFKEQRKKMSEADQSKEVKAAMEKAKEKRLQRGGDYSDDDRDISTIDSDDSDHSTAPSGRGRGRGRGRGRGRGQGSTARGSRARGGRAGSQAAGNRSKQSVLTSSFVQASKPASRNSRTFGDSDDSGDESVSSRATASSTSSRKNSNQRNAKRSAVQFLDSGDSEEGDEFDDFPPSSRRNKPSTSKRGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APJ7</accession>
    <name>A0A914APJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065396.1">
        <property type="nucleotide sequence ID" value="XM_038209468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065397.1">
        <property type="nucleotide sequence ID" value="XM_038209469.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065398.1">
        <property type="nucleotide sequence ID" value="XM_038209470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APJ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209468.1">
        <property type="protein sequence ID" value="XP_038065396.1"/>
        <property type="gene ID" value="LOC119735664"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209469.1">
        <property type="protein sequence ID" value="XP_038065397.1"/>
        <property type="gene ID" value="LOC119735664"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209470.1">
        <property type="protein sequence ID" value="XP_038065398.1"/>
        <property type="gene ID" value="LOC119735664"/>
    </dbReference>
    <dbReference type="GeneID" id="119735664"/>
    <dbReference type="OMA" id="RKDVHTQ"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09519">
        <property type="entry name" value="SAM_ANKS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047238">
        <property type="entry name" value="ANKS3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF6">
        <property type="entry name" value="ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="539"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="838" mass="90616" checksum="0A8204CEC55B0492" modified="2023-02-22" version="1">MDYPYEASDEASESELLDKSLSMWRGWGTLGEDPAFQPTPLDLHTAASIGLYDCVSAYIASGEVNINHRNRGGWTPLMYASYIGHDNIVNLLLDAGAEVDLRNEKGATALMLTASCGNESVAYFLVQQGAELENRDNKGWTTLFYATYAGHQKVVQFLLDNGANVNAREPRLGITPFMMAAAEGHEIIVNLLLEHGVDVNFKNAKGETARSLALLNGHMKIIGLIDSQGMAPSGLRSEPAQLPAVDLSSSDESYQRPNRPHARSGRSKTKGPSIRDGPETLAKLLSERKGGRLGAVLPSAGHALPGDYVAYQIEAEQSIGHQLSRADVPALVNPEETASSRVSENTCNNVWLNPFPPHYPAANNDDDDPAFCISGALTIKSSTSSNSSGGGGGFAAALGIGSSSHSSADEQSSETSSFSLPPTPSSNSSENAGFAGALSDQLSQMISADLTRRGFGLVDPLFTEPLVTSGLRREEHGVPGSLPNMPLLAGPHPHQSQSTNPTMDAYATNGVGYHSSVLPLSSDITQDAPYDKPADNKQYPYQDLASLLESLGLRTKYFHIFEEQDVDLRVFLTLTDSDLKEVGIKLMGPRRKMTNAIARWHSQARPFSDNLEQVYADRVETAMQEMAIQLQEAMVKKGEMEAQVMQERELRSVVEGCLMEDRKTYQQLLSLVSDARKLCHNMRQLYDSVRSCQTELIRRLQAFPSFIPKDVRFDSLSQQFVSQLQIDRPPRRGGDNPSPPPTPDKNPLVSAITSSLITGDSSMGASQSIPATSTGAPLSTSQEGEELAKLTMKDLLSMLSQGSHQLGRAVAMATNNMDQLIDGQTVNFSPNSSGNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQU3</accession>
    <name>A0A914AQU3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066425.1">
        <property type="nucleotide sequence ID" value="XM_038210497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210497.1">
        <property type="protein sequence ID" value="XP_038066425.1"/>
        <property type="gene ID" value="LOC119736480"/>
    </dbReference>
    <dbReference type="GeneID" id="119736480"/>
    <dbReference type="OMA" id="FDIRCER"/>
    <dbReference type="OrthoDB" id="1099686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF530">
        <property type="entry name" value="MSTPROX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="10">
        <location>
            <begin position="428"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="600" mass="66490" checksum="E127D336481768AD" modified="2023-02-22" version="1">MYPYEIDREQPACNNLPDCSCPSYGDTYGLELGLTLSCRVGPNGFNFSQFHGLNLTMNLWWSLEFYSNFNPDGHSSSPLVIPRNAIPASASVTPFRLLINNVELVSVERGAFAGRTLTVLWFRGTQMTSLPLDSFRDQSANLKLVVIQGVSQKNGEPIGFPSFHSFQALRTLAIEHTPIKYLPDQFFIYNLLSLEEFILDSAQTTQGVSPRAFQDLPVLSSMTILKCMLQQVPIDALSSLANLTNLDLSLNDIQTLSAVDIEALKRLPSLFQVTLGDNPFSCTCDLLPFIKLLQGGSPFDIRCERYGLNSNNDCRCASPEQLRGKLLADLSHVNWSVCTAESTVKPENLTTRDYVDSSTVTRRARDYVDSSTVTRLSISIISAVVVLGIAVVVVVVIVHRKMKLRWVGLFRRYDRPNSNVYEGDGEGYAYDAYICHHSEMEVFVSEQMIQRLEGEPNNFRLCVSFRDFLVGADKLDNVATAMTSSRLIIVLLDANFIASGQCMLELNMASTRMLDATVGAAPVAPAAAGNAAIMDGAAGLLLVLLDALPVDALPATLTVLRDKITCLEWRQEDEERCWRQLVASIQATRPRQPQQMDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR54</accession>
    <name>A0A914AR54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
            <ecNumber evidence="5 13">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_038066138.1">
        <property type="nucleotide sequence ID" value="XM_038210210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210210.1">
        <property type="protein sequence ID" value="XP_038066138.1"/>
        <property type="gene ID" value="LOC119736184"/>
    </dbReference>
    <dbReference type="GeneID" id="119736184"/>
    <dbReference type="OMA" id="SIANECE"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037010263" description="Alpha-amylase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="415"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="58214" checksum="4122A04A569CAECE" modified="2023-02-22" version="1">MKMFCLIMVLLCSCSAQWDPHTVDNRQVIVHLFEWKWTDIADECERYLGPFGFGGVQISPPSEHRVIRSPWRPWWERYQPVSYELTSRSGTEIQLRDMIRRCHQAGVRIYVDAVINHMARGDSGYGIAGNWYDVNTLNYPGVPYNITDFGRTNNKCKSDSGNVEDNDDVNQVRNCRLLGLPDLDTSRDDVRAKISDYMNHLIDMGVTGFRVDAAKYIWPEDLGNILRRLNNLSTEYFPSGRRPFVYQEVIDKNGAGIRRNMTEAEYVPFGRVTEFKYGPQLGEAVRGLRNLSNINNWMKSEGMLDDSSALVFVDNHDNQRGHGGGKGIITFKEPEKYKISNVFMLAYPYGFTRVMSSFVFDNTEAGPPADANGYTLTVTVYEDGTCGGGWVCEHRWRPIRNMVAFRNIAAGQPLRNWWSNGSQQIAFGRGDRAFVVINNDDYRLSQALNTGLPTGEYCNIIVGDFDPLTATCSGPTIRVDQSGNANFSIDTSADPMVAIHVGARVDQSIFGRPSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARK1</accession>
    <name>A0A914ARK1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048276.1">
        <property type="nucleotide sequence ID" value="XM_038192348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066074.1">
        <property type="nucleotide sequence ID" value="XM_038210146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192348.1">
        <property type="protein sequence ID" value="XP_038048276.1"/>
        <property type="gene ID" value="LOC119722303"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210146.1">
        <property type="protein sequence ID" value="XP_038066074.1"/>
        <property type="gene ID" value="LOC119736132"/>
    </dbReference>
    <dbReference type="GeneID" id="119722303"/>
    <dbReference type="GeneID" id="119736132"/>
    <dbReference type="OMA" id="FEDESHN"/>
    <dbReference type="OrthoDB" id="10070456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275705" evidence="2">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="261" mass="29078" checksum="6DB1308BA24E02E5" modified="2023-02-22" version="1">MEWAVVWMAAILLSGLDQVEAQGSNGGISGLAIGLIVAGAVIFFVIVIVAGLCCFNYKRKHLGRLEFEHPEFERSGEPYFRTTSLTRDPVPEPVQYDATIDETAIDGPAGADSDGDAVSADVVFSPSKSEKKEKFEQQLVELQPHAVTFQEMLKDVQERIKNAKHGNPRVQGYKAVSRDLSRVQHLLSKRNSTALKMPPDGLELLAWAAETRQKYLELQRYKSERDRGTSSEPPEMASIMWIQSKDDSVFEDKSYDESAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUV4</accession>
    <name>A0A914AUV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067865.1">
        <property type="nucleotide sequence ID" value="XM_038211937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211937.1">
        <property type="protein sequence ID" value="XP_038067865.1"/>
        <property type="gene ID" value="LOC119737513"/>
    </dbReference>
    <dbReference type="GeneID" id="119737513"/>
    <dbReference type="OMA" id="CDDHIYR"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF70">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="355" mass="39765" checksum="537C4D6EAAFC79CD" modified="2023-02-22" version="1">MGNNQSETLVNHYTNYSNGQVVEYVPSNQEPCKSWLLLPAENLWSVPLRGILYITAMLYIFVGIAIVSDIFMCSIEMITSKKRKILRWDSESKKHVEKEVLIWNETVANLTLMALGSSAPEILLNILETCQHVQDYDPNNPQDSLGTFTIIGSAAFNLLIITAICISSVPSPDAKKVKEFGVFMVTSVWSIFAYIWILIVVVWNSPGEVEIWEAWVTLLYFPLLVMNAYCQDNGWWIKRPKVGGTEPQSGSQMNIRVVNGNVKKHHVFHGPSPQLAALEAERSQSQMNLKATTDERTNDMLVLKDLEAAPEDGRVERSDEEKKQLARASFACTFTPSLGGFRHAAVRSILGVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWE5</accession>
    <name>A0A914AWE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067824.1">
        <property type="nucleotide sequence ID" value="XM_038211896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211896.1">
        <property type="protein sequence ID" value="XP_038067824.1"/>
        <property type="gene ID" value="LOC119737494"/>
    </dbReference>
    <dbReference type="GeneID" id="119737494"/>
    <dbReference type="OMA" id="IERYEEC"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000024">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000270">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="179"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="604" mass="66550" checksum="3F432847A479F673" modified="2023-02-22" version="1">MDPDRNEGAALDSWEEQADPGPGNHGDTVDIGSEFSALNVNAKPFVPNVNAPAFVPNFGNFTPKTEPCNNEDTEDKPSGQASPAQDSGIAETEDETTPQHPVPDASETPPPDQDGEAEPEEDEEEEELNSSPSSEEELGARAVTETVAQSSGKSSPSVAVKKPKKYEEEEEDKERKTEMEHVNVIFIGHVDAGKSTIGGHIMYLTGQVDKRTLEKYEREAKEKNRESWYLSWALDTNLEEREKGKTVEVGRANFETEKKHFTILDAPGHRSFVPNMICGAAQADLAVLVISARKGEFETGFERGGQTREHAMLAKTAGVKHLVVLINKMDDPTVEWSEERYELCKTKLVPFLKKNGFNPKKDVFFIPVSGITGANLKEKAGGVCPWYTGPAFIPYIDSLPSLGRKQDGPLRMPITDRFKDMGTILLGKIEGGKIKKGDSVLMMPNKTNVEILQILSDEDDTTEAKAGENVKLKVRGIEEDDVSPGFVLCEINSPCHTCKVFDAQILIAEHKSIICAGYGAVLHIHTAVEEVQITTLIALVDKKTGKTIKQRPRFIKQEQIAIARFECAGVLCMETFSDFQQMGRFTLRDEGKTIGFGKVLKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWK0</accession>
    <name>A0A914AWK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068083.1">
        <property type="nucleotide sequence ID" value="XM_038212155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212155.1">
        <property type="protein sequence ID" value="XP_038068083.1"/>
        <property type="gene ID" value="LOC119737661"/>
    </dbReference>
    <dbReference type="GeneID" id="119737661"/>
    <dbReference type="OMA" id="PSWIWEY"/>
    <dbReference type="OrthoDB" id="9997229at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100121" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="20">
        <location>
            <begin position="23"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="426"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="867"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="751"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="910" mass="104158" checksum="9D3B0C4E767EB4A4" modified="2023-02-22" version="1">MRTWRVSLLLQMMTVMLVTVSAFEFSFEAFYGNTSDIDDEYKRIIDDAKEDVNKEYPQDSLRVTHFQPRRAANSAEKLFSTNSFQALKLDVCPGIFSAGAQGLIVPNDVCYECRSVGAMVGNAVNPTIALDQAEGSKAIKMLPTTSEMVDLFVHLINYTKWYDFIVLYDQYSGLDVAVSMMGYADIYGWNVKMQNVNDHDMLTKTLKASRVRNLLLYCEYQENAMDVVRLAIEEGMMEDSYHWMLGNLNMPLTWDHVSAIRRSGAYITRLQVETKNNVASDFQTQKPEPLDEWPYRLRLAYDAVLLFSNALQRYKQRTGRFPTERVFCQTTEEYTYSPLDPEIKSVSFEGLSGEVAFNEHGDRVNYTIRIYMGKGTTVYVHNDVEEIQPLGTWTQNIKHWELKYGRQWQSKERLNMGPFRNAQVDTIKIVSLEEPPYLLDDSRVGIQGFIKEFLIHLKRVMEEELGQNFEYELELVSEGDYGRYDIVTNSWSGLMGRLVNGYADIAAAPMAITPQRDRYVDFTVPFIKSELGVLIKHPSWIWEYPFAPVFPFRWDVWMVNLLAFVVVTVAMTLIGRYNPQEWSRAAERGEASQEQSQSFNVWNTFWFNVSTLFLQSFDSSPRSVTGRVLAAFWFFYCIVMVFLFLFNLTPFLTSSKSIGIVRDVGDLLDETTVDVGFIKDSPAYDFFKYSDIEDFTRFWEYIHAANSMYGDETTIEFRVEEAVQRVRLSNGRYALIHDKEVLKKEAARWPCDLYITGGHFALVEYGLAVQSGSPLRDQLTYAVRRLQEKGIIDEIWKNNTDNPLWVELNKEGSCQENATIWEIQGLYSLTTVDMKGIYFLLLLGMGLAVIIFLIEVLAFQLGFGSSSPGHTGSRQEMQNLRGSDRRTGGGGGMGGPMGGADVGGNEKMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY20</accession>
    <name>A0A914AY20_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069040.1">
        <property type="nucleotide sequence ID" value="XM_038213112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213112.1">
        <property type="protein sequence ID" value="XP_038069040.1"/>
        <property type="gene ID" value="LOC119738275"/>
    </dbReference>
    <dbReference type="GeneID" id="119738275"/>
    <dbReference type="OMA" id="PCGEFKY"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037367237" evidence="1">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34350" checksum="CB8DB819D31C84C6" modified="2023-02-22" version="1">MLRLDVTLLCLVSFSAAYVQGLEHIPLTLNVESGLQEIPCGEFKYYAVEVTDPCRDLRVRVNKIEGEPDLYVSRGYNKFPTDSSLAWTSYEWGSEKLVISSWDPEFEVGMFYIGVHAYCGIDVETGNTPSKVTVLAESIPTTHPHSEITVDTPFTGEKVSAEGYNYYRFCLPSQCTDVEVKLVNCLSSQDCPYSYGYPELLVSRSIVQPTIKDHSWKLASLDRRSIVMKHDNPDVSPGHHYVAVYGWCTPDEFCSDKSTCGPCDYYANMTYDVSVVMTDVGDCSGAANFMPSSLVVCLAVFLMKFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYA2</accession>
    <name>A0A914AYA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plasminogen receptor (KT)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068499.1">
        <property type="nucleotide sequence ID" value="XM_038212571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212571.1">
        <property type="protein sequence ID" value="XP_038068499.1"/>
        <property type="gene ID" value="LOC119737917"/>
    </dbReference>
    <dbReference type="GeneID" id="119737917"/>
    <dbReference type="OMA" id="MGYYTDW"/>
    <dbReference type="OrthoDB" id="10256697at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019319">
        <property type="entry name" value="Plg-R(KT)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13411:SF6">
        <property type="entry name" value="PLASMINOGEN RECEPTOR (KT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10166">
        <property type="entry name" value="DUF2368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16276" checksum="F629362035FBF503" modified="2023-02-22" version="1">MGSFMAKAMDESFKKNKVFMEESQAVMLERQIQMQNQMRERAVAMQLSGAREMFTWFSSFYGVTAFFCLAGFLKRKNPAVLGPLLPLTFILGYQYDYTYGTKVLRIREGAESILKEERNLLPVPLGLPNLASIDAARNASESSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ54</accession>
    <name>A0A914AZ54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068953.1">
        <property type="nucleotide sequence ID" value="XM_038213025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213025.1">
        <property type="protein sequence ID" value="XP_038068953.1"/>
        <property type="gene ID" value="LOC119738235"/>
    </dbReference>
    <dbReference type="GeneID" id="119738235"/>
    <dbReference type="OMA" id="MLISIMF"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="38991" checksum="ADD6F2D718033E40" modified="2023-02-22" version="1">MSTVDVGHRTEPLTMKAVDVGNKTDDLWIQTTHSPLLDGVNSIIACLGVLGNGMVITVMLLRRRVFSSFTNRLILHQSVIDCVTCVVFFLWRVVFQNVYKNVSLEGNIYDQLICRFIYVDYFLWCLDVTSTCNLVMISLERFMATCHPVKHRNTWTPAKLKFAVATAWAIGFIYGSHFVFMFEARQGRCRFVELKIGWKIFEASAVITVEYLVPIIILIYTYSRIFIVIKKSANLLNGPRNFINKAKKNILVTTMLISIMFVVCWTPIEVFYVCAYISGIWGGWLYATFTGLLACNMFVNPIIYCFKYEHFRSELKSLVIRRCRTSRVGDGEAIPIPAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZW4</accession>
    <name>A0A914AZW4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069252.1">
        <property type="nucleotide sequence ID" value="XM_038213324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZW4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213324.1">
        <property type="protein sequence ID" value="XP_038069252.1"/>
        <property type="gene ID" value="LOC119738427"/>
    </dbReference>
    <dbReference type="GeneID" id="119738427"/>
    <dbReference type="OMA" id="ALSKYMW"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038163413" description="Phosphatidylinositol-glycan biosynthesis class X protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="32738" checksum="6147B26BFD56BBA1" modified="2023-02-22" version="1">MHSKSSYCVVCSRFVVCLWVVAASQTDARVAVRDHFDGKGLPAGIVEQLRSIDNEDFGEDSCKIVPKDVQLTRHSSRSGFHRDIHTSVSVLLDQSHHCTSCHLLLIERLPGGLYVDLYQSAAAVDFGGPQILAFEEIDLEKPAYLSAGHTILVYPSSSPQIIPQGREVVVNFTTEMPIHLRYHRPSAEPDAHSAHVSLPSPYALIRCTGASHIGTQTTADDDADGLPVYKAPCSGTSNTNCLWRLLPQSPRENHELHFQVPVGQQSHTLLVTVVTILATIAGTLAVLVTMFRSSTKAKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B366</accession>
    <name>A0A914B366_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-D1-binding protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069941.1">
        <property type="nucleotide sequence ID" value="XM_038214013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B366"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214013.1">
        <property type="protein sequence ID" value="XP_038069941.1"/>
        <property type="gene ID" value="LOC119739182"/>
    </dbReference>
    <dbReference type="GeneID" id="119739182"/>
    <dbReference type="CTD" id="23582"/>
    <dbReference type="OMA" id="HEATKFC"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="9">
        <location>
            <begin position="209"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38322" checksum="B04284E0878D65EB" modified="2023-02-22" version="1">MASSQLDNIFDTFIENLDMVINKLKEEDSPRPTSPSYNLEDFWKKLGTAFESVSTEATKLAVWFSKPPLPKPDECQSLIASVEMSAIALVSAFYGLPKEKGVILRKGTRHAVTEVVEGMKALTKQIKDDHYHSSESQLRRTGNVWECCDAIKMLPRNNRDALLGVLRDAGGLVKDAVEELTELQETGGQSQGWEDLDPVISGTPSSDSNLQEEGWSEHDRTLLPPSMGLLKAAKSCVKKVSGAVRANGQWEEESLAAQLDDLGEIAERISPAADDMVMCLYPQIRHQDVRQNANKLAEVLLSLLDRTKTSHVAKEADNAWLTFLSKAVDHNLEKITHLTAPAPNDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3P5</accession>
    <name>A0A914B3P5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070121.1">
        <property type="nucleotide sequence ID" value="XM_038214193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3P5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214193.1">
        <property type="protein sequence ID" value="XP_038070121.1"/>
        <property type="gene ID" value="LOC119739311"/>
    </dbReference>
    <dbReference type="GeneID" id="119739311"/>
    <dbReference type="CTD" id="23315"/>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036724149" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="25"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="132"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="642" mass="70561" checksum="16E1BDFACCFE4C52" modified="2023-02-22" version="1">MNVSVLRGLLVALILIDWSGCVASDPFGSVLSKEVKRVRRSGDNDKNDKETKPPAPPEEQPSEMSTTEQINGTGLGNESDTTPASVLQTLTEAGPVKTTTEDSQLPAQDSAEEEHSSSLALFFILLILALSIILVHLLIKFKFHLLPESVAVVCLGVLIGLISLLTKNAKNAEYKLTDYEMMDPTMFFLILLPPIIFESGYSLHKGNFFQNIGSILVFAVFGTVISASVVGGGLYLLGQAQVAYKLDLVESFAFGSLISAVDPVATLAIFSAIDVHPLLNMLVFGESILNDAVSIVMSATVINLNSQEMANVTSSEAFGYAVGSFCLMFSASAAIGILIGIISALLLKHIDLRKTPSLEFAFILIFSYLPYVLSEGLKLSGIMSILFCGITMSHYTHHNLSPITQINVQQTFRTLAFLAETCVFVYLGLAVPTFNHDFQPAFIIWTLVLILVGRALNIFPLSFLCNKFREHKITLKMQLVMWFSGLRGAIAYALSLHLMFGNQTRHVLVTTTLVVVLFTVVVIGGLTMPVLKLIGPESGKPKKEVTLSKTEDLGSAVDAEHLSELTEEEYEVNYIKPHLTGFVKWDTKYFLPFFTRRLTNKDLTDGRIQMRHLANQWYSEVRGTKSDTEEELETSLITAEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3R4</accession>
    <name>A0A914B3R4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070563.1">
        <property type="nucleotide sequence ID" value="XM_038214635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214635.1">
        <property type="protein sequence ID" value="XP_038070563.1"/>
        <property type="gene ID" value="LOC119739612"/>
    </dbReference>
    <dbReference type="GeneID" id="119739612"/>
    <dbReference type="OMA" id="TEVSERW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="261" mass="29358" checksum="9A53231E0809AB29" modified="2023-02-22" version="1">MWTIEGAIYNSSKWQPPLVQLREPYYIIMEYIRNGTLQDYITQKRLAWGKAKTSGTESASKEALSAVHILMFAFEVANGMEYLSSVHLIHRDLATRNVLLGEGLVCKLCDFGLARDVTGSEQYEMLSGSAVPVRWLAVECLLSNTYTNKSDVWSFGILLWELVTLGALPYPDMSPDAIVDSVRQGFRLPRPAHCGLALYNLMASCWKASPKARPSFTELQTKLDHFLKFDSEALDMPNFVANYYAYPEASKKGYTQVAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4B2</accession>
    <name>A0A914B4B2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-1,2-N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">GlcNAc-T II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannoside acetylglucosaminyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12941"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="EC" id="2.4.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 16 (GT16) protein family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.143" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038070644.1">
        <property type="nucleotide sequence ID" value="XM_038214716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4B2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214716.1">
        <property type="protein sequence ID" value="XP_038070644.1"/>
        <property type="gene ID" value="LOC119739694"/>
    </dbReference>
    <dbReference type="GeneID" id="119739694"/>
    <dbReference type="CTD" id="4247"/>
    <dbReference type="OMA" id="FWSAEIN"/>
    <dbReference type="OrthoDB" id="6019616at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008455">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007754">
        <property type="entry name" value="GlcNAc_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871:SF0">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871">
        <property type="entry name" value="BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05060">
        <property type="entry name" value="MGAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16 26" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="28" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517376" description="Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" evidence="28">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="26">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="362"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="401"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="54766" checksum="1E0829E65C7C9645" modified="2023-02-22" version="1">MRLRRLHKLAIAITCLLMYTMYRVTNDDNDGNQDGGVAGGANAGADHSLNVAKPVQPVKPNKGQSEEHPRVKKQDAVVIGVNHNVKEVKQSGPEVLPANPVKVRTNRTGEAERIRQAILDVNSKEEVRNLARFPTRSNASVVILVMVHKRLEYLRYLINSLRQVRDIGDALLIFSHDYYSEEINALIRTVDFCQTMQIFYPYLLQIYEKEFPGEDPGDCPRDMKRDRAKEIKCNNWEHPDKYGHYREVRFVMTKHHWFWKLQHVFGGLSATKNHKGLVLLIEEDHYMTPDAYYMLQKMYELKGSKCSECDIFTLGTYEKSRRYKDRGNTVDVLQFYSSRHNMGMALDRSTWDRLQPCVKEFCNYDDYNWDWTLQHVSLTCLKPSLSVIVPKAPRIFHIGECGIHHKGKCNAAELVKQLDSVVASSSDYLFPESLTMTPLTRALYRKMPKPNGGWGDVRDHSLCMAYGQTDATKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4H3</accession>
    <name>A0A914B4H3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070704.1">
        <property type="nucleotide sequence ID" value="XM_038214776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4H3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214776.1">
        <property type="protein sequence ID" value="XP_038070704.1"/>
        <property type="gene ID" value="LOC119739737"/>
    </dbReference>
    <dbReference type="GeneID" id="119739737"/>
    <dbReference type="OMA" id="PADAFCC"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000008">
        <property type="entry name" value="Putative TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="640"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="918" mass="101610" checksum="45C4D252E7C9C051" modified="2023-02-22" version="1">MNAEVYVTDEANFEASTFPAMDSQAGTLAGNICNNPPHLPQSVRVTAGNSGSEFREVFISSSEITNQSAGMGVAAEPPQFTTVARSQEQQNDGQRVNGVGEGPISRTAVRCSGNESVAASNETPGLSDGQRITTRMEDVSLDSPTTVENLLTSASSDTTTNKSDTTSSSSSNPLQGPVKLCNRTSSSLGNLVITENNGNQAIHSSCDAIGSDLATASPQDAIRLEPDLLRQCGERMPGDGQEHPSDSNPNQSCGTTSIASAQSGESSLEQPAVLDVTSSEELILSDIELSGESPASPATIDVINLGSQSPIGSKLRRPRSLEGCLDLDDRPSKWTTPNKSQSLRTTPSTSTPRFLEELNEAGTAVIELQEPTLEPLQDGQSDSRNPRLSGILQHELRSRASFTSVSSLSTDYSSSLATDDLSENRDSLEPGFVEVNLHSQLSGGDHWAYTTQGAKPKKKGLAGFLARNLFPWKTSAKSSVDQVDGPPASSGWKLFNRSPAKHAAQHPAQHPAQHPDPYDSNYPPKGKTHPPTLSLNWKKKQAGMRPATSTTALILENRPQHLPAKNPDEEQKHKEQYEEMVKGAKQKEIKVYKQQMKKLAKQLKYEEGIKTLLHVWQTDLLKNWDHSKTNKKTREMWWQGIPPSIRGRVWMLAIGNELNITPELFEIFLARAKDLIKVFNEPDTEDSEEVHEASREDSVDVIRLDVSRTFPHLCIYQKGGPYFDRLHSVLGAYACYRPDIGYVQGMSFIAAVFLLYLEPADAFCCFANVLNKSCQLAFFRLDQPVMQSYFDTYEEYFEDNLPDLYNHFKSQCLTPDLYIIDWMYTLYTKSLPLDVACRFLDIFFRDGEEFIFRTALGILHLYEDILISLEFIQLAQFLTKLPEDIQCDQLFKSIEVVDMHQKKFSQVLAVHLANNSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B708</accession>
    <name>A0A914B708_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071991.1">
        <property type="nucleotide sequence ID" value="XM_038216063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B708"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216063.1">
        <property type="protein sequence ID" value="XP_038071991.1"/>
        <property type="gene ID" value="LOC119740685"/>
    </dbReference>
    <dbReference type="GeneID" id="119740685"/>
    <dbReference type="OMA" id="CAYTVHL"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="37328" checksum="EA9FA2FFE3BA9B3A" modified="2023-02-22" version="1">MYRVYPPWLSVLLVLFALVGLLSNIVVIVTIFKSRFLHDVTHYLILNLAVSDGLCCFMFGLEMFMDLLNYPNNRTGPIAEILYCRLVHGNYLFQSFAYVSAYNLVTISLERYVGIVKPLRYVKVCHKSNIRCAVCLAWMLGFCAYTVHLFGLIYDPSEATFAKRCRLFHDWQWHFVPFVGGFVIPLLTMMWAYSRIVKALKESALRQQVSHQARATQEATKRVVHMMLLVTVAYVILYIPTQPAYMIIVSIKLGHFELTPLGILLTDLISKLPVLLNSFINPFIYAFKYKKFRKGLREILCGRQRNGLVHAGGKKSEQSIHTVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B817</accession>
    <name>A0A914B817_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072306.1">
        <property type="nucleotide sequence ID" value="XM_038216378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B817"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216378.1">
        <property type="protein sequence ID" value="XP_038072306.1"/>
        <property type="gene ID" value="LOC119740903"/>
    </dbReference>
    <dbReference type="GeneID" id="119740903"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000744">
        <property type="entry name" value="Smt3 activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="39149" checksum="0EAEF0541F40F878" modified="2023-02-22" version="1">MADITEKESAVITEAEAALYDRQIRLWGLEAQKRLRGTRFLLAGLGGLGAEVCKNVVLAGVKSITLLDHSCVSELDACSQFLVSREDVGKNRALASVANTQELNPNVRVTADESNITSKSEEYFRQFDIVCLTCCSYKTLDRVNRICHDIGVKFFAGDTYGFYGYMFADLNEHDFVEEKIHFKKDPVSDKDDEPQPKKQSFHKETSYVKRTLNFCRLNNALQKDWTQLSPKQLKYMPKVYFVVQALWKFQQEFGRNPSPDKLENDKTELLRLRDEVLDEAGIKADFVSDDFASHCAAELSPVCAVVGGVLGQEVIKAASCRDIPHNNFFFFDGLESTGMVACISDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8L5</accession>
    <name>A0A914B8L5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038072170.1">
        <property type="nucleotide sequence ID" value="XM_038216242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8L5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216242.1">
        <property type="protein sequence ID" value="XP_038072170.1"/>
        <property type="gene ID" value="LOC119740807"/>
    </dbReference>
    <dbReference type="GeneID" id="119740807"/>
    <dbReference type="OMA" id="PRDKKVW"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037714163" description="acid phosphatase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="432" mass="48865" checksum="A55E5E598B048DBC" modified="2023-02-22" version="1">MHRFFLIFIVLLCRGGFHSFAGLVNGQRTLQLVNLLYRHGDRTPVNIYPTDPHQADTWPEGLGQLTTLGMNMHYNLGQWLRKRYIDSGFMNATYNRLSLHVRSTDKDRTLMSAESDLAGLYPPQGNQKWKAGFDWMPIPVHTVPLDEDYLLEANGPPCPVYDELKEQIKDEAEYKELEAQYKDFMANLTINTGFKTPVTVNNIYKIEDPLFVERQHNLSWPAWTNVPGFYTTLKFLSDKGMYFLFNSKEKSRLKGGPLVGQIIDNMVNKSTTTDPDDLRRRVYMYSAHDTTVAAFQSALGVYNGLQPPLASCVGIEMWKEVSGEYTVNMWYHNDTTKDVPYPLLLDNCNRSSCPLDDFIKVTKDIVPDDIKQECGVAAPVGLNSTLIIILVSIVIGLLAIIIIALAGLVVCRCRSNRTKDGHIRLPTDDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B942</accession>
    <name>A0A914B942_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072519.1">
        <property type="nucleotide sequence ID" value="XM_038216591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B942"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216591.1">
        <property type="protein sequence ID" value="XP_038072519.1"/>
        <property type="gene ID" value="LOC119741020"/>
    </dbReference>
    <dbReference type="GeneID" id="119741020"/>
    <dbReference type="OMA" id="WFIENET"/>
    <dbReference type="OrthoDB" id="6148851at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="320" mass="36122" checksum="000B613CDB65E3B9" modified="2023-02-22" version="1">MIFMYLDDWLVVGRSRGETEAALQLTWHLASDLGFLINTKKSHPVPSQVPTFLGAFLNLRRGLARPSEDRLLNLRQCVSLFLPTVVAPARAWLRLLGLMASLVDLVDFCRLRMRPIQLHLLSFYRPRWHPIDHPVPTTSLLVPHLRWWLVEANITQGRVFRPPRPSVLITTDASGYGWGATLHPRQVAGVWGPAHQSSHINVLEMLAVTYALKHFQSDVRGQAVLVRCDNATVVPYINHQDGTRSGHLCALIDRPHVDLFASRMNNQLPIYCARGPDPNAWQTDALSVRWDGLLAYAFPPISLVSRVLTKIEQEDAEFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B945</accession>
    <name>A0A914B945_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071952.1">
        <property type="nucleotide sequence ID" value="XM_038216024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B945"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216024.1">
        <property type="protein sequence ID" value="XP_038071952.1"/>
        <property type="gene ID" value="LOC119740657"/>
    </dbReference>
    <dbReference type="GeneID" id="119740657"/>
    <dbReference type="OMA" id="CGWWMHE"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="437" mass="51679" checksum="E536E16975CB3614" modified="2023-02-22" version="1">MGKGQQGQVVTRVGRDAAYSWDEIKKHNSRYDKWLVIENGVYDVTRWMTKHPGGFKVLSHYGGEDATEAFVAFHPDKSLVRKYMKPLCIGTLEDNSPKSELVTDMEALRVKAEGMGLFKANMWFYAAYFGHILAAEVLAWLLLWYFGVGWVPYLLATVLLTIEQAQSSWFLHDLGHLSVFRKSRWNHLLQYFTTGALKGASSHWWNYRHYQHHAKPNIIRKDPDIKMPYLFVLGDKQPVTWGTNKRKYFLPFNYQQIYFFFTLPPLLMPLYFHLEYFAHVIRKRLWKDLAWMCVFFIKHALLFGPLLGGFGLFFNYMFVKFLESNWFVWTSQMNHIPMQIDHDQHKEWLPAQLQATCDVESSFFNDWFTGHLNFQIEHHLFPTMPRHNLYKIVPDVKALCKKHNIRHQTKSLSQAFADIIRSLKHSGELWYDAYYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B949</accession>
    <name>A0A914B949_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072651.1">
        <property type="nucleotide sequence ID" value="XM_038216723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B949"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216723.1">
        <property type="protein sequence ID" value="XP_038072651.1"/>
        <property type="gene ID" value="LOC119741069"/>
    </dbReference>
    <dbReference type="GeneID" id="119741069"/>
    <dbReference type="OMA" id="HYNSGTH"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="120" mass="12352" checksum="47416189CD769D6D" modified="2023-02-22" version="1">MPQLNYGNGPNYGNGPYYGNGPNYGNGPNDGNGPNDGNGPNDGNGPNYGNGPNYGNGPNYGNGPNYGNGPNYGNVPNYGNGPNYGKAGDKLADVSCAGRATFRSRSQYDSAALSLWQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B979</accession>
    <name>A0A914B979_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071987.1">
        <property type="nucleotide sequence ID" value="XM_038216059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B979"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216059.1">
        <property type="protein sequence ID" value="XP_038071987.1"/>
        <property type="gene ID" value="LOC119740684"/>
    </dbReference>
    <dbReference type="GeneID" id="119740684"/>
    <dbReference type="OrthoDB" id="6340082at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="18745" checksum="C4DA9E4F470D252A" modified="2023-02-22" version="1">MTLLLSGSLSLSPSCNRRHGLCTAPWKKWGGSCYLITQKSLTYDDAREACRRLGAKMAAPHSDQENDFLASLAQGSKIWVACTDRRQEGEWECDGSQVGQGIYTNWWVARGQPDNIGGNEHCATIWSPDKKWNDYRCNGEQLAVCKQQPLTHCFITNSDGRLEADSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9A3</accession>
    <name>A0A914B9A3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072012.1">
        <property type="nucleotide sequence ID" value="XM_038216084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9A3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216084.1">
        <property type="protein sequence ID" value="XP_038072012.1"/>
        <property type="gene ID" value="LOC119740703"/>
    </dbReference>
    <dbReference type="GeneID" id="119740703"/>
    <dbReference type="OMA" id="RCAKNTI"/>
    <dbReference type="OrthoDB" id="9944627at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="324" mass="37079" checksum="1F3D27A96A261061" modified="2023-02-22" version="1">MQAYPSWLSVLLLLIAVVGFLSNVLVIVNIFKSRFLHDVTHYLILNLAVSDGLCCFIFGLEMFMDLLNYPNNRTGGIAEILYCRLINGNYVFQSFAFISAYNLVIISLERYIGIVKPLRYVQICNKAHTWLAIFLSWVLGSCVYLLHLIGVQYLESETEFNIRCRNKHPWQWHFLSFTVGFVAPLLIMIWAYSRIIKALKQSALNQAVSAQAAETREATKRVVHLMLIVTITYAVLYVPTQPVYIIIVSVNQQDFEQLPLGILLTDILTKLPVLLNSIANPFIYAFKYKKFRKGMRDLMCRCAKNTISPNEDVMMQVDTANSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9P3</accession>
    <name>A0A914B9P3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 171</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072560.1">
        <property type="nucleotide sequence ID" value="XM_038216632.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216632.1">
        <property type="protein sequence ID" value="XP_038072560.1"/>
        <property type="gene ID" value="LOC119741036"/>
    </dbReference>
    <dbReference type="GeneID" id="119741036"/>
    <dbReference type="CTD" id="203238"/>
    <dbReference type="OMA" id="CRRFECD"/>
    <dbReference type="OrthoDB" id="287623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37476">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37476:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="694"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1336" mass="153136" checksum="EE0A9EF5C4FEF840" modified="2023-02-22" version="1">MATNSSPDTANNSDFHRKSSSPFLKDLEVTEELRQLRLKIARLQDEHQSEIESNTELRKRVTQLENEKLNFTASSNEEVNQLQAQIAKFRAQFEKSEAARQQLEYEIVVAKRGISQEKNLAAEREDSLNTIIETHRGKISELTSQVQDLQSSLVSQRRFADDTDVKLRVSLEEKDREVQAVKAERDVIRSEKEQLEQVFHEQENIYAETQEKVNELKTERDTQTNTVRQQLRELQYAAEREDRLKKEVEVAAGRIKTLEGTIEAERAAHLESKFNSELVQLQARDLKGALEVEKSAHSEVGHNNEIMTKQLRDLEVVLNDERSAASSMKQQAESFSRENELLKQQLNAETSSKKTIITNMSAQLEIHQKNFDELKQELSRAKKRQVYLEQTYGGSMRELELLLHNFQLNGDKTTSSRRGKTKKGDSKTNENLSPMLVLETLRHTLTDYQKRLDMTSQELAKMKTRSDMMATECEKYKEVTWTRSQTMQDLQKKFSSGCKELEQLRRQLSESESQVTSLKMQLQQTTHHGEMEGSKAAEMMEEYGRRVKEYQDEEEKRRIYLHSLYQRIMAGRIVLDPKEPILSSFTWDELSIAVQDQIVGLMTGLNRANEKVSHLETVIHNKDELLREVQHSHEESLERLSVKGKEQEKKWQHQRSQLEEQFSQQLADLHIKSQKTQTLADQAWEKARLTGTVKQGLEAECTELRDQLTLATRERSRLLIGCCLMAGALMPMFSRVSQLAAQRASLEEQVHGLETMRRQAQELANTLSMEVNDLKKDYQDNKRPARNLVMLFRKAVIVVLAANRLHHFGLRSCGIFTAVDNPSGIHSVPVCSGDVKQPQRPFTGLRSSPDKRSHRSHVQSNVSGWLTSSVLLTAVVDSCSELHELLSDKDESKSQPQTISNTAKSCFIKLMSKLTPIFEASCLHPSRRSYGTRDKGMLVRLLGYGLSRGITHSNIDGTRNMTSSQEIMACLQRNIINFTQRLHTAEVERRSLRLETAKLRQENDELKMETERAKGMENEITQLRDVRQNMVMREKFDSVCQELSKALSREQQAQDLLNEQSRQLEELGMRLNMYTTEELEKDATITEAVKGLSEAKMELRRKDQSIHQLSKKLSALEEEKKSLQCSVQDVQSVLRSSNKDKDKLAGYLQAVQAAVEDTKRQLIGRADNRSIDAALRQVLIHPEERGLDGISAEVIAIKSLVAAFVDTVQTALSRLVALETEIASHKQHIATMKEELNAACRRAYPDEEQEQLRDGFLRHDASRIPERSFGRSRPLYETDRSYKEQFIPLREEPDFSMMTQEGASGMKPSPYTAQTTPLATSTQRKSTNRGRHFNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAV9</accession>
    <name>A0A914BAV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038072582.1">
        <property type="nucleotide sequence ID" value="XM_038216654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216654.1">
        <property type="protein sequence ID" value="XP_038072582.1"/>
        <property type="gene ID" value="LOC119741047"/>
    </dbReference>
    <dbReference type="GeneID" id="119741047"/>
    <dbReference type="OMA" id="KHQQENP"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000046">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="297" mass="33795" checksum="B45CBDF7CBBB6D38" modified="2023-02-22" version="1">MMAESASGSAVPVHNIMEMTIWDPTTSKDWDQQKATHQCILRIKRDIMNIYAEPPPGMCVVPEEDITKVHALITGPFDTPYEGGFFHFLIRFPPDYPIRPPRVKLVTTGEGKVRFNPNLYRNGKVCLSILGTWTGPAWSPAQSLSSVLISIQSLMNENPYHNEPGFEQERQPGDCERYNDCIRHETIRVAVCDMLESENPSMPKTLREVMKKSFPEFYEYYMSTVTDKSHLTGQCMQDPYGERRGKFQYNALKMSLEKIKQKLDEEESLNKTSEADSSSTSDNEMDTSSPCPSEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBS9</accession>
    <name>A0A914BBS9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 61</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073489.1">
        <property type="nucleotide sequence ID" value="XM_038217561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217561.1">
        <property type="protein sequence ID" value="XP_038073489.1"/>
        <property type="gene ID" value="LOC119741702"/>
    </dbReference>
    <dbReference type="GeneID" id="119741702"/>
    <dbReference type="CTD" id="65999"/>
    <dbReference type="OMA" id="YWESWPT"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27982" checksum="7107E1FC0557AF52" modified="2023-02-22" version="1">MDQESREKTELFGTRITKQILKTRSGEFDLESIHCLILREMDIDHLGCIGDCTYLERLDLSRNDLANLRPLTPLKHLSYLNISANRITSIDPLKELANLQTLNASGNLISSVDSLQCLANLDSFSSLTLSDPLTGLNNPVCHGSSYKSSVMMILPRLKVVDGERVSGSGSELFELCRKLDEMLEGSTESTTKTNLPQPWVSKDFWEAKGAVDADQQRWSAEQQFQDLLKSCKDLEFDASRSLMESTENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBV1</accession>
    <name>A0A914BBV1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073698.1">
        <property type="nucleotide sequence ID" value="XM_038217770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073708.1">
        <property type="nucleotide sequence ID" value="XM_038217780.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217770.1">
        <property type="protein sequence ID" value="XP_038073698.1"/>
        <property type="gene ID" value="LOC119741854"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217780.1">
        <property type="protein sequence ID" value="XP_038073708.1"/>
        <property type="gene ID" value="LOC119741854"/>
    </dbReference>
    <dbReference type="GeneID" id="119741854"/>
    <dbReference type="OMA" id="FPYDERA"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF72">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1489"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2161"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2003"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="3778"/>
            <end position="3815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3031"/>
            <end position="3079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2004"/>
            <end position="2017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="4467" mass="508991" checksum="9002E05A1D492B29" modified="2023-02-22" version="1">[encoded data, 4467 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCI7</accession>
    <name>A0A914BCI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073943.1">
        <property type="nucleotide sequence ID" value="XM_038218015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218015.1">
        <property type="protein sequence ID" value="XP_038073943.1"/>
        <property type="gene ID" value="LOC119742008"/>
    </dbReference>
    <dbReference type="GeneID" id="119742008"/>
    <dbReference type="OMA" id="QQFQSWH"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="484"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="598" mass="67301" checksum="446A85ED14A13453" modified="2023-02-22" version="1">MAGWVSGGQYVLSSSAHSCPDKTALLLKLTDSSLKTIERYQKSKGYTKETPSILFKGRKGIITFPVRDGGDSDGFQDFKFTVQPLSVPTGSSYECIQQFKNSKGEPHLDSISQIKTKVIVSATDDVYQTTQEKMKLADEEMKKISTKEVSQKEVKATRKVNRITKRPSLTTQTKSTHVQRSSQPSHSKPSHTSSAISRSNGTLAPSSRTPQVTAKGAPTSKPATPNRSYRDRVIHLLALRPYKKPELILRLQKDGIAMKDKNQLSNILSQVATLSRENAYILNKHLYSEVQEDWPLYSDVDRQLLRKNLRSLNQKEHSSSVNSTPSVSLSSSLSSSSSSSSLKQAFVRTVTRMPSKDVPQTRPVAKPDPVRTAADKFKARISHKRPLLPDVVDYKQPKKTRIAHNTKKLSPTPDATSLSCSPPSKYDVSSTTKQSPDYNAPSRTSKPQEEKDTKCRVPVTESKAKPVVGKQSPPSDVSSTSSGPDYLNKFTTITSHEQKQRYREIFNKEYIEYKKMHAYVESVTLKFTKLKEELHRAAEDSEEYRQIKQKVLDEYTKIQEDSVYQKKESRWRELHDKLGHIKGVIAAYDNTRQRVTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCT2</accession>
    <name>A0A914BCT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073655.1">
        <property type="nucleotide sequence ID" value="XM_038217727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217727.1">
        <property type="protein sequence ID" value="XP_038073655.1"/>
        <property type="gene ID" value="LOC119741821"/>
    </dbReference>
    <dbReference type="GeneID" id="119741821"/>
    <dbReference type="OMA" id="IWQSESW"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47156" checksum="07A88335F3DB16DC" modified="2023-02-22" version="1">MPSLTNSLGIWQSESWDRAAVRHSYSQLLDNMAPNHKLSEVSVDGEYLTGKNYLAKNGRFWLWFLVGTLLNVCLIAASVGLTVMYVHTELQSLKDQMQIHEERLAWLEDASSKQDAGKEGVPTWKYAQLRTRRDQEPQVSSGNSGQQNATLLPGYGPGNAGVVFCRDGRDGRDGKDGHDGAQGPAGPAGQSGIKGEKGDPGIDGDQGSSGVMMHRRAKRALGDGDSSLTAENRESGAHDVYPTLKPSGGETYIRWGRTTCLNDTSTELVYAGFATGAHYTHKGGSVDFFCLPSDPEWSASHNDGINSNSFLYGMEYEVSGFDPFSHENAEFLHNRDVPCAVCRLVDRGTQLLFPAKLGCPENWTEEYRGFLMSGHHGHEQRSKAVCVDVAPEAIPGSKTSQDGALLYIIEGKCGSLLCPPYVEGREIACTVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCX3</accession>
    <name>A0A914BCX3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073694.1">
        <property type="nucleotide sequence ID" value="XM_038217766.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073695.1">
        <property type="nucleotide sequence ID" value="XM_038217767.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073696.1">
        <property type="nucleotide sequence ID" value="XM_038217768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCX3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217766.1">
        <property type="protein sequence ID" value="XP_038073694.1"/>
        <property type="gene ID" value="LOC119741853"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217767.1">
        <property type="protein sequence ID" value="XP_038073695.1"/>
        <property type="gene ID" value="LOC119741853"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217768.1">
        <property type="protein sequence ID" value="XP_038073696.1"/>
        <property type="gene ID" value="LOC119741853"/>
    </dbReference>
    <dbReference type="GeneID" id="119741853"/>
    <dbReference type="OMA" id="FIIHEFR"/>
    <dbReference type="OrthoDB" id="10056560at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029201">
        <property type="entry name" value="Jiraiya"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39947">
        <property type="entry name" value="IP19862P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39947:SF1">
        <property type="entry name" value="IP19862P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15038">
        <property type="entry name" value="Jiraiya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="27448" checksum="E7ED117C67E28AFB" modified="2023-02-22" version="1">MSEAPGSPLSLKQSGPWNSMSLSRLTFAGKDQGITKSLAALGILSLLSMLLGGLSVLLIIQLSIRQDNPPTTEAASKRIGGVIWTERFLESSVVLACLCAMLCFGSLVSCTAQCYFAAKMLKLPQGEERAHRFLGDTSGTRFLAVSSFFTAIPVFIAALTLYVIHEFSLVPAALSTSFLGLGLIFMFTTFGRSVWLWRREHDLIIRGVGVFEYNGTSAISSLDGRAPFTFTNNVSTEAEATRNQSTDNNLSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDU7</accession>
    <name>A0A914BDU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073607.1">
        <property type="nucleotide sequence ID" value="XM_038217679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217679.1">
        <property type="protein sequence ID" value="XP_038073607.1"/>
        <property type="gene ID" value="LOC119741784"/>
    </dbReference>
    <dbReference type="GeneID" id="119741784"/>
    <dbReference type="OMA" id="HGGINWL"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55890" checksum="04C7715480CE3C1E" modified="2023-02-22" version="1">MGSGSSKKAKQLEAEEREFKKRNMQKGKAIDDEEEEEEVGEDGKKRKKKQKDDEFLLGTCKGHKGGINCMGINEDGNMIITGGEDKTARLWNLATFECTKVLKGHKGYLTCAQILDEFCYTGAADRTVRKWTAKTGVCELVIEGHAAPINRLICTGDFLFTSSYDRTAMCWDPDDGELLHIFRGHRRGVTPLMYIPAEDALKDDVVDIESNRDILVTGSADGTARSWNMDSGDSLVTFKGHKGGVLCLAADSTGSILFTGSADCTVRSWNINNGEVFKVFEGHQSAVVCLQVMNKLMYTGSSDQTAKCWVTEFGDCTRTYQGHKHTVSTVRFRDGLVYTGCGDNCGRVYDAKSGALKRTFKGHEYCINAILVMPQKMLTASHDGTAKLWDCSGIKDEITSFGDEEEEKERKKAEKEEKKRQKELKKKEKKEKERLEKEKKKKPSNQTEDRESLPEKNNFEKSEKEPEEKQDTGKEDGDGLDEDISREIDMINKDMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG92</accession>
    <name>A0A914BG92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074895.1">
        <property type="nucleotide sequence ID" value="XM_038218967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218967.1">
        <property type="protein sequence ID" value="XP_038074895.1"/>
        <property type="gene ID" value="LOC119742795"/>
    </dbReference>
    <dbReference type="GeneID" id="119742795"/>
    <dbReference type="OMA" id="ILWICAM"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="38735" checksum="22D78B482BE62CBC" modified="2023-02-22" version="1">MSMKNATSLISLEEAQTDVWVCQIIAAEGVFGFLGNLLVCFVILRVRFLHTMTNYLLVNLAVADMLLCLCTFFHYLFASSRCTLINMVPSSSLGRELYCRLVASQSLIWVFFNASAYNLCVVTLERYIAIVHPLKYARKVTATRMKTLVTLLWMLSVLLALPFLFTIKASDDLDKACSDIEYLNQAFPILLSVVLVSFTYIMPVIMMSWAYYKMQVTLKRQAQALNLQRARAAAVDLVIARQRVISMLTIVLGALIILWTPDNVSVILCLYPTSDSILNFCGSESFKYISGITSFLIYLNSVVNPIIYELKYKKFRKGLRVVFCTCLDEHGGSNSVDAEMARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI97</accession>
    <name>A0A914BI97_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075625.1">
        <property type="nucleotide sequence ID" value="XM_038219697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219697.1">
        <property type="protein sequence ID" value="XP_038075625.1"/>
        <property type="gene ID" value="LOC119743294"/>
    </dbReference>
    <dbReference type="GeneID" id="119743294"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="87" mass="9596" checksum="9891DF61F049F02F" modified="2023-02-22" version="1">MSDTALPAEIMKLIEQSQEAKTHAHTRGKFRVGASLLTKDGKVFKGCNIHNASHSLSVCAERCAIFKAMSEGHREFKAIAVSRRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLU6</accession>
    <name>A0A914BLU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077089.1">
        <property type="nucleotide sequence ID" value="XM_038221161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221161.1">
        <property type="protein sequence ID" value="XP_038077089.1"/>
        <property type="gene ID" value="LOC119744688"/>
    </dbReference>
    <dbReference type="GeneID" id="119744688"/>
    <dbReference type="OMA" id="WEPKRSA"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037402146" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="298" mass="31942" checksum="FBB3011617A784BF" modified="2023-02-22" version="1">MGGAVAWILMVSVLTVLSGGVEGKQRVCYFGHPPEPDTDNPDDWMKQVMQEIRERCPGRREPTQAGHTTVGEEPTPAGHTTMGKEPTTAGHTTMAKEPTPADHTTMAKEPTPAGHTTTEKEPTPAGDTTTGKTPTPAGQNIGTNTSVDSACMSPEPLGLEDGTIPSDRIRASGSSNCCPAEDGRLNLENGGWEPKRSADSWIEVDLVNSTVVLGVTTQGFNQWYVTQYKVAYQKLSSSNYEHVTDGNGDIKIFNGNTDGVTLVTNLFNESVVATVVRIEPTAWNSDVNLRFEVLGCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP57</accession>
    <name>A0A914BP57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077486.1">
        <property type="nucleotide sequence ID" value="XM_038221558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221558.1">
        <property type="protein sequence ID" value="XP_038077486.1"/>
        <property type="gene ID" value="LOC119745298"/>
    </dbReference>
    <dbReference type="GeneID" id="119745298"/>
    <dbReference type="OrthoDB" id="6431448at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="39178" checksum="2562D59BC92A15FA" modified="2023-02-22" version="1">MSSPQADLKNALPAEDMEDNNTFSTPIKMSEERKHWNMWGLMKRLATKESTVEFCKEQGLIATDPICKWCRRLLRWSPTEHRGDGFSWRCNNRRCKKRARSRSVRHRSWFADSSLSIEKVLVLTYCWAVGMTNKVAVRESSISGTISSPKTVVEWFNYCREVCLHAVQQSSSKAIGGPELVVEIGESKFGKQKLNRSRNMEGKWVLGGICRKTRDVFFIEIDNREPATVISLIKEYVAPGSTLVITDCWQSYDCFSADNFKDLNVYHTVKFMSPPTGALTRNAESQWTQTKRKLLGSTTSSCGGFGLYLAEYIWRRKNRDKDSFQQILDDILLLYKPPKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS66</accession>
    <name>A0A914BS66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078461.1">
        <property type="nucleotide sequence ID" value="XM_038222533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222533.1">
        <property type="protein sequence ID" value="XP_038078461.1"/>
        <property type="gene ID" value="LOC119745879"/>
    </dbReference>
    <dbReference type="GeneID" id="119745879"/>
    <dbReference type="OMA" id="LICAFMD"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="279" mass="31443" checksum="7AD28A79CD3F9F11" modified="2023-02-22" version="1">MYVHTYIHVRGVCGRDSRGLGPPPGRAACVPDFKLHQHQILLRNLFFCKQIYHMEARKVPQQVAETTGQLIHKIHLLTPEQMLEYYENWADSYDKDLKSSDYEAPGICAEALGKVLSDKSAPIVDCAAGTGIVGEELRTVGFKNVDAVDYSQQSLDISASKGVYRRLICNKFDENKIEEIKDDSYSGLICVGALGMNHITQSAFPEWNRIVQKGGFMVFTLSRVEYDDDVPDHRLVIGNGIQELLNKGTWELIEKTAIPYHSGYLADMFTIRLKNKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BST9</accession>
    <name>A0A914BST9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079353.1">
        <property type="nucleotide sequence ID" value="XM_038223425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BST9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223425.1">
        <property type="protein sequence ID" value="XP_038079353.1"/>
        <property type="gene ID" value="LOC119746463"/>
    </dbReference>
    <dbReference type="GeneID" id="119746463"/>
    <dbReference type="OMA" id="KREDYQV"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="19302" checksum="ACBB520238D855F2" modified="2023-02-22" version="1">MPRKTKASKKTQKAAAAPIDVIDIDDDCEGGDAGASKTFPIQCSALRKSGHVMMKGQPCKIVEMSTSQPGKHGHAKVHIVGIDIFTGKKYEDFCPSTHTMSVPHVKREDYQVIGVWDECVNLLDNKGISRGDIRLPEGELGTQIKTRFEAEEELMVTLMTSMDRDMICGLKKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXR3</accession>
    <name>A0A913YXR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044157.1">
        <property type="nucleotide sequence ID" value="XM_038188229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188229.1">
        <property type="protein sequence ID" value="XP_038044157.1"/>
        <property type="gene ID" value="LOC119718810"/>
    </dbReference>
    <dbReference type="GeneID" id="119718810"/>
    <dbReference type="OrthoDB" id="9408020at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037241767" description="TNFR-Cys domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="255" mass="28286" checksum="CBC5F1EADE1759DE" modified="2023-02-22" version="1">MPRFQYSLFCLVLLGFILHANALKLAERAADDEPHPYCILGPDQEGVSKFQLGPGGTEYRICRRGHFFNFNPGPLGPIGCTTCPRNTHYMDSRNYCPQCKQCTVCGDNEKEIVSCTPYRNRICEPTIIIPSNVTVENQYDFTTMDSTTALADATLTSTTPPTCPPCVSRAPTNNSSSTTSVTRKEDELTQQNQCIDQNIVIVSTFCGVFGLIAVIEFVLILYCKRRKKQEGNNPNNGPADAYRRVPPGDICLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z087</accession>
    <name>A0A913Z087_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045238.1">
        <property type="nucleotide sequence ID" value="XM_038189310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045239.1">
        <property type="nucleotide sequence ID" value="XM_038189311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z087"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189310.1">
        <property type="protein sequence ID" value="XP_038045238.1"/>
        <property type="gene ID" value="LOC119719818"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189311.1">
        <property type="protein sequence ID" value="XP_038045239.1"/>
        <property type="gene ID" value="LOC119719818"/>
    </dbReference>
    <dbReference type="GeneID" id="119719818"/>
    <dbReference type="OMA" id="MGNNFRT"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008103">
        <property type="entry name" value="KiSS_1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01728">
        <property type="entry name" value="KISS1RECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="48"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="377" mass="43389" checksum="4090FCCB114AE724" modified="2023-02-22" version="1">MTSLEPATTDPLNSSSSSYDYYYTSEPGPETIFVPVLWSLIIGVGVITNCLVVYVVLFQMKMSTVTNYYIVNLALTDITFLLFCVPFTTLTFTLYGFLTEGICRFMVYVQQASVHATCMTLTVMSADRYFAIVYPIKSMRYRTRRLSLVLNLGVWILSYIMAAPAAIFVGVRSHWYYVDYKYSCVETFDTHATKSVYYTYVFVTTYILPLVIICACYSLLLHAMWTKQLTANTSFRARKNLQQKKRTTRMLLVVVFLFFLFWLPTHVFNCWDRYVPGGVPYHINAVYYLRIIAYSLAYSNSCVNPFVYAFMGNNFRASFRKAFPCCFRRQIGARNSTRRLQRRGTEDGGTRVTVLAPRMDVQMNVNNNMAPIDQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2W3</accession>
    <name>A0A913Z2W3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046173.1">
        <property type="nucleotide sequence ID" value="XM_038190245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2W3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190245.1">
        <property type="protein sequence ID" value="XP_038046173.1"/>
        <property type="gene ID" value="LOC119720542"/>
    </dbReference>
    <dbReference type="GeneID" id="119720542"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="223" mass="25755" checksum="9C5FB09D126C9396" modified="2023-02-22" version="1">MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTNLNEQVPHYRQALDMILDLEPDDELEENPNQSDLIEQAAEMLYGLIHARFIMTNRGIALMLEKYQQGDFGHCPRVYCENQLVLPIGLSDVPGEAMVKLYCPKCQDVYTPKSSRHHHTDGAYFGTGFPHMFFMVHPEYRPKRPPNQFVPRLYGFKIHPTAYEIQLQAAAARSRSASSRPRSAKPPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3N8</accession>
    <name>A0A913Z3N8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046448.1">
        <property type="nucleotide sequence ID" value="XM_038190520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3N8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190520.1">
        <property type="protein sequence ID" value="XP_038046448.1"/>
        <property type="gene ID" value="LOC119720709"/>
    </dbReference>
    <dbReference type="GeneID" id="119720709"/>
    <dbReference type="CTD" id="8443"/>
    <dbReference type="OMA" id="RFNLEWY"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="665" mass="74622" checksum="7CD56FB4A4370C98" modified="2023-02-22" version="1">MAQSSDEYLDLLEPRRNQYDLSFALKHTASLLPEYQYVTHMTKAEIRTMVLKSRRLKHTVEEIVASNGRQEKDIYAEAEAILDEMAHEYSLNNIRFLAYIFAKTFKKLYGHIYVSKTGLEKLRKSYRDSPVVLLPTHRSYVDFLLISYMMFEYNLPLPYIAAGADFNNMKFVNTLLRKAGAFYIRRSFGADKLYWAIFTEYVQILVINGEAPLEFFPEGTRSRTGKFLPPKRGLLQVVVEPFMKGRVPDISLIPISISYDRILEETLHSREMLGIPKPKESTSGLFKASSIFQENFGNITVHIGDPVSLKQMSLISGVDRSVHSLAPRFIFSMNAQEQQFVQELCLSIQLMQQRHMVVSPWVLTAALLVMSPGYQTSLQGMYSDMEWLKGAATGLGTKVRWPVGKTVKSVLEDVLAVHHAMAVVDRDSIKLNVPQNVATAEEVMEVATVYIMLGAYRNQLLPSLAQPALVSLAFCGLNAATKGELFAQYQFLVTLFNRELTFHPKTTVDDFQSTLRKLQNSSFISVTGLQYSITSSGERLTSFLCNLLHPFLLGYWVVCRYLLSCPASLASVTEQSLAKTIQKEVAELIATGDLKSYDILSLNLLGNAISSLLQLGGIKRSKSGLTLIESEITKTAEKISEYIELPASLLTKPFAKKLAGPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3R0</accession>
    <name>A0A913Z3R0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="10">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038045345.1">
        <property type="nucleotide sequence ID" value="XM_038189417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3R0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189417.1">
        <property type="protein sequence ID" value="XP_038045345.1"/>
        <property type="gene ID" value="LOC119719935"/>
    </dbReference>
    <dbReference type="GeneID" id="119719935"/>
    <dbReference type="OMA" id="YGELWNE"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1960:FF:000001">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000001">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000073">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040986">
        <property type="entry name" value="QSOX_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041269">
        <property type="entry name" value="QSOX_Trx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18371">
        <property type="entry name" value="FAD_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18108">
        <property type="entry name" value="QSOX_Trx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036941780" description="Sulfhydryl oxidase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="13">
        <location>
            <begin position="439"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="660" mass="74630" checksum="0A9822FD42F1136E" modified="2023-02-22" version="1">MKMEAQHCIWIVFYLLAIENWPCNSVNMGSTSLYDPSDDVSVLNNSTLKGAIFGSKQAWFVQFYSSWCGHCVHFAPTWKEFAGDIKGWQSIAKVAALNCADQNNNKICSQYIDTGFPTLRLFNALQKNGTGDVYKGSRDVTSLRHALIEHISKQISSQNAPPHWPMLSPVSVQWLLTFYSRNVKPKMKIVAIVFEDADSYTGRELILDMSNTKEVLVVRVLQEELLRNPLPPEWNVGELPSLLILKRNGHPSVLWRSGNRESFFKALQEYIQKTLPASDITGGSLSKTGQRPETLKVQKETSYITNGSHIDGTKAGQHQGKTQAKPIANDTSGKTAARSVVYMEDLESTLIYSLKYEVGLQKEIGADAMGALQAYIAVLNKYFPGRPDVMNTLKQLQRLLQPYTQLTSDDWSNVMNRLQTSQDPGYFLQNEVTWVGCQGSTQVYRGYPCGLWVLFHTLTVSHARLDSHYRKSDSKEVLHAMKGYIHYFFGCRACSENFAKESVHLESSVSTLDDSVLWLWQVHNSVNKRLAGDLSEDPQHPKIAFPSYSDCPTCHNVNSPRRWKNTRILQFLKELYGVNNIDFAVSGVRSKAHELITAETLKRLNVGATVSYGYARLGIDTRDVSMCVLLYALCSVLLVVIFIYVKRRRRRKLFQNKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z413</accession>
    <name>A0A913Z413_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038046573.1">
        <property type="nucleotide sequence ID" value="XM_038190645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z413"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190645.1">
        <property type="protein sequence ID" value="XP_038046573.1"/>
        <property type="gene ID" value="LOC119720800"/>
    </dbReference>
    <dbReference type="GeneID" id="119720800"/>
    <dbReference type="OMA" id="PQDHIKY"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22978">
        <property type="entry name" value="DD_AK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006267">
        <property type="entry name" value="AK1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01360">
        <property type="entry name" value="aden_kin_iso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119049" checksum="2A1ADB36D78518F6" modified="2023-02-22" version="1">MTSKDDTKTYLSKREIPQLFESLMTGLMYHKPGNHVDYMLECLGKIKDNKSEAVRWNTFVDGAKGQAPLPPIQSQDAPVLDREPTFTTEVPLEMKRSSALPPIATSPGAATASKQGIPPPHTRFIFVIGGPGSSKSEHCKRLTDRYNGYVHISVGHMLRRKIKKYTEDKWKMLADAVLNGQQVPHETAFELVQAKISSKVQKLSDIQGFIIEGFPRGMEHVQAFEKQFGAVDLVLYLMCDETRLRFRLEKRKDTSGRSDDTDVGITNRLANFSSSVPVIMDYFQQKGVLHQVNCDRDVEEVFYDVANLFDSRFFTQDASDNSEQVGKDTMSKPLPPIQTGEKTETDKKDKPEAAEEEEAVVSETSGIMSAVNHLAGDDERKEDSAEKSIVDKMAEEKAALGAEGVAMMDMFNKIEEVSTGTPEDKDKPESQPSDQPIVTEEPITSEEAYITGDKGRVPDEDAVTEEPITSEEANITGDKGRVPDEDAAEKLKKCKIIFVIGGPGSGKGTQCEKLVDTYGFTHLSSGDLLRAEVKSGSERGQRLTAIMEAGDLVPQETVLELLKEHMLAKADTSTGYLIDGYPREVQQGIEFEKQFAECTCALYFEVSDETMTTRLLKRAETSGRVDDNEETIKKRLTTFHNATTPVVDHYQQKNKIIKVSAETDPDSVFSCVKDALKERGIESQNSAEKLKKCKIIFVIGGPGSGKGTQCEKLVDTYGFTHLSSGDLLRAEVKSGSERGQRLTAIMEAGDLVPQETVLELLKEHMMAKADTSTGYLIDGYPREVQQGIEFEKQIAECTCALYFEVSDETMTTRLLKRAETSGRVDDNEETIKKRLTTFHNATTPVVDHYQQKNKIITVSAETDPDSVFSVVKDALKERGIEAASSAKQQRFIFVIGGPGSGKKEVAKKMAAQYKLVHLSAGELLRAFSELDTPESKEAAQVIQAGSLVPQEVLFKVMQEEVKTNASADGFVIDGFPRTVAQAELFVSEFGYIEGALFLEGVREELLNNVSSRAESSGRSDDSADVAGAKLDVFEAELPAVLGYLEKQNKAVKKELSFKDAADDVDMLLDVLNAFSASDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z502</accession>
    <name>A0A913Z502_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045820.1">
        <property type="nucleotide sequence ID" value="XM_038189892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z502"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189892.1">
        <property type="protein sequence ID" value="XP_038045820.1"/>
        <property type="gene ID" value="LOC119720267"/>
    </dbReference>
    <dbReference type="GeneID" id="119720267"/>
    <dbReference type="CTD" id="51690"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000025">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="101" mass="11256" checksum="72365D2CBBE48EF4" modified="2023-02-22" version="1">MAQEKKKKESILDLSKYIDKPTRVKFQGGREVTGILKGFDPLLNLVLDGTSEFQRDPDDPYKITEDTRDLGLVVCRGTSVVLICPADGMEQIANPFVQQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6Z4</accession>
    <name>A0A913Z6Z4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047578.1">
        <property type="nucleotide sequence ID" value="XM_038191650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6Z4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191650.1">
        <property type="protein sequence ID" value="XP_038047578.1"/>
        <property type="gene ID" value="LOC119721571"/>
    </dbReference>
    <dbReference type="GeneID" id="119721571"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="137" mass="15492" checksum="B5E6FC7A0131B37A" modified="2023-02-22" version="1">MNWFPHLLLALHYWLVPGLIFLTLLRLPVANGYFGLTSNTQLTSIHGSDQCPHYLTKRQRKMCGRDSGMPAALADALELSISQCQERFQNERWNCSIHNTSQRANLLKRGVEVRAPGSLDAVEVRAPGSLDASYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8H4</accession>
    <name>A0A913Z8H4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048098.1">
        <property type="nucleotide sequence ID" value="XM_038192170.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192170.1">
        <property type="protein sequence ID" value="XP_038048098.1"/>
        <property type="gene ID" value="LOC119722129"/>
    </dbReference>
    <dbReference type="GeneID" id="119722129"/>
    <dbReference type="CTD" id="286464"/>
    <dbReference type="OMA" id="PMTNEAK"/>
    <dbReference type="OrthoDB" id="10060824at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21218">
        <property type="entry name" value="CH_PLS_FIM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058952">
        <property type="entry name" value="Ig_CFAP47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26579">
        <property type="entry name" value="Ig_CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="1787"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1457"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1601"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2061"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2576"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1457"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1484"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1513"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1615"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2063"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2084"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2102"/>
            <end position="2112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3275" mass="359306" checksum="8447F203372B59C9" modified="2023-02-22" version="1">MAGDISGVRIIPPVIEFMDAEANAVHVQTVTVQNISKCSKQIKFHGPNTNKFKLIVKNPDKPIAPGLEVTATIEFFTEEPQDCQDGLILLVDEDVVEIPLCVYSPQPLLDLEGPANFGTVVRNSKVLSTQVSLYNHGSLPGNFKINYTGLQPITIFPCSGTLQPKTAQVIKVEFVTKNAGVLNEEVPVQLEAQQPAILHIRANVVERCLELYAPDSDEQIDCIKFGSTYYGTDKTQMAMLYNNGPDPVSFVTVLEENAEGMEAGTDLTKSTVATLATKDMDRVRSSTNELTSLVTAIPSQGKLAPYQRAPVFFRFSPRYNTAQQGWKGTATPPPRQDFALFMQIVVIGSSKGFGAENDAGKQNGNEGTKVEVALTGTALPVLLSLSPTNHFDFGECPVGEHVDTLCTLRNDATHLPVSFVCRQVAQFCVYPSFGKLTPGESQDLIFSFKPNQYGSFKLSQVMDVLGSVADEGEEANPLATHLEAIYGLHISLHGVSNAESKKREPKFNPGITPRVVGEVGQFVDVTMDEAKPYEPRAAMLGAPKTKGLHATRSAGHIPDARALVAYPNDRARSIRPSYRRVQYKTIFTKTERHTYVDPDYAYDDNELATIQKHKNVYNDYLKNSRERRIGKTKAKEFLELDNDKDIGLKPASGLKPGKLKVDEIKPPTKTPSPRDKSRRMLSSKQLAEKELNSTSRPFSRGLNAVPMTPQEKADCKKILTPQQLHQVVIGPPTIDFGQVCLKSTSVQKLSIINNLDQFIHVEVDIDCRELRQTSPLSQVVPPNCKAALPLIFESNTKGRFQRNVTYTVNKLNKEHVIVYADVVAVALELSTERLELKPTPGLPAEAGLRDIITLRNSRNYPAEFTWQPILGERGTAFSIRPASGTVDPLKDLECEVVFHPSYHAPEDGEFALKVHGGDTLKLKCFADLGSTQVMFMERRVLFGQVPLHLTTSRSAVLQNTSQNHAYFQVVDPSPVPGLTVTPVQGVVPVGGTTELGIYFTPGAVMKFDTRLEVAIRGWKTIELRMGGTVEPPMVDIDVPTFQLGGVYCASNLTVPFKLINKARTRAKVVFDLSRFRDFSLKFDADVMEESEDTMNPGVYKVTVGGMQTIKCQLNFQPTEVASYDFIMPVSINQTEAPTPESTPFPPTPAPSTKSINHIITPRPVLVTVATPRRRIVATALRQPLQLSHSNLDFSLPSGYLDFGVAGSPSQTQGTLLVNNSSKSLKWSLDLSSCGKAMEEGIFRFLMPNGMPFLSFKEGGGTVKDTLAPGETYPLGVMFCPDEPGEFHAKVPIILNHDESRPYLHIHLYGVLKSPQLTFDPLAIVLTPVPLATKVSADFTIQAAGFRKETVIDVELPDVELDDGSKMSVLSVTFPDDQTIQPCCGDEGDEEPFILKCKVTFCSPRPVSFTQPVKFVDTQGNSFSIPVTATADNCLLTAYPFVAQHRTDFQIVTEQGQTLRGRRSSANSKESLGNVGEAVMIPVESPSRPSTQRSSASTSSRFGATTSTYEESTDSITESTYRSTPRDGAVNRAVADRSIIDPESRLGLASRSLGSAAFPNEDTEEGVFHQEVLMAIQRWITLHGWSGGPYPVSVPEGLRSGVAKNSAPEQARDKASQGSPATNNSKTSRSKTIYDLMAHMSGRLVPGIPINQALPADPTERVLQLHWQHSTLLTFLRSQGASVANVKPEYLFEPQDYQRWVKLQEQIRDRKKAQQQGKSTVAIRIQEAPLDEILFESVSKRAWTDLLLQTLKALVLARITPRQFKALSSGSSSLPAINPDPLCSNIYSVGERILLAWLNHHYEQQRHKIWKDCDKGGVPPSRWVVNFDYDLLDGLVLAAVLAAHVPFLIKSHLQSMYTQPATAEQCLHNALQVVNAFRYIGLDYDIQAIDVTDPNPISLLLLCVHLYQRLPQYTPRTTVEFVGSLHACVARQVRLTNPSTKPLIYHAMIAGRDARDFTLPRGNTVSIAPKGKHDLPVEFTSRFLRPAEGVLVLVGRRAGAACGTTLVFNLRTSIDNITPSTTVKCESPCYELHKVELEVTNPFDQAGEFRIVLVEAKSPFPGTDATTQKNGLLNQKQGPPKKVRSKTDHGQKKERTPSPPKADNQSPRSELFEQDSSNQLSAFHCARQSLQLDSHSSAVIAIDFLPFHTGKRQCSILFINESIGEFLYSIEAVAGLPMPSALPYMPTKHSVRISSAAAAGNGRGVYGGDDRIIYWRCDSNTVLHEELTIPITNAAREKALVIAAQQRMTETEIRRRQTTGTLASGSVTAAIAALGLTDETVLTGKTSANPNSKSDKPDGCRFTVEVNSKYFESPSSVFVPSPLTLKPKSAAEIVTNGHMVDRSSAGLVGNAGVILDDGTVRLPVKFTPKSAGHYPCRVVLRSSNDIRVYLIECTVNPEGTAAQIEFTAPVHQSVSQEIPLVNQTSVDWPLTASIDGQGFYGPPFIMAKAMQTTQYPLMFRPAFETLVSGKLVLTNSEDGTEHHFRLKGEGQKPLALDHVILECQARQSVKRVIRVPNVTQHKLTYRAVSDLSIVNGTVPSVTVLPGKEADYVITVSPWKRGTFRGILSFIAGGTDNLKDEASPEDSDAPSRPDSGKRPISGKSTSSSTSVHIHQSKPGYRVWYSIEVRCSPPPPERNIEIVCAAQSAVVMEVEIFNPTINDLTFSTVIEGEGLRGEGEVTLTPGQKRMYQLVYAPAIVGKSEGSLIFQNETVGEFWYTLSLTAEPPAPTVLPHMECELGKWSRQFITLSNPTEETLELTPSCSNTNNFTLEVEGEIKIILAPHSTQEIPLQFMPSSLGQGNHLARVAFSCEQLGDWVFMASGTGLTPTPLDPVSVSSILGSNTSLIIPFRNPLNEAVLIDVVLSDNTDLLDRARNKLERNRIQTDSAFCLLLKHTMGIPIGPKSTLDIPLTFAPDNMRLHEALCVVSVKREDGSSWEYEPCRDPDHPYACRDYDRRDTQGGLRDIRWLYPIHGIPESQPIIDRGAVVSCQARSRIEERLEVSLTGAVPSSASGYHRSVMTRAVTPKGLEKAHSTDGVVVGEGNTVASEFSFELFYSTEEAQAHLEHAVSLNLVRKQRDKLSGIVTLVFNVVFAPFKVMNHDVQLCVTAATGGVWRYPVRFTSTEPTVDDVITIESVGLSKEASVGFRLTSQARHPVAFNAYFVAGSDQEFTVSPQSGELKPIGTNGTLITVGFRPKIYGKSYQAKLVVQTADMQWTYSLIGVTPDYVPPTGQSQRPIAGPHTSGMRHNKPRNYVLENLKLTTTAVSSPIKGAPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8S5</accession>
    <name>A0A913Z8S5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048048.1">
        <property type="nucleotide sequence ID" value="XM_038192120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048049.1">
        <property type="nucleotide sequence ID" value="XM_038192121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048147.1">
        <property type="nucleotide sequence ID" value="XM_038192219.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048148.1">
        <property type="nucleotide sequence ID" value="XM_038192220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8S5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192120.1">
        <property type="protein sequence ID" value="XP_038048048.1"/>
        <property type="gene ID" value="LOC119722098"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192121.1">
        <property type="protein sequence ID" value="XP_038048049.1"/>
        <property type="gene ID" value="LOC119722098"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192219.1">
        <property type="protein sequence ID" value="XP_038048147.1"/>
        <property type="gene ID" value="LOC119722173"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192220.1">
        <property type="protein sequence ID" value="XP_038048148.1"/>
        <property type="gene ID" value="LOC119722173"/>
    </dbReference>
    <dbReference type="GeneID" id="119722098"/>
    <dbReference type="GeneID" id="119722173"/>
    <dbReference type="OMA" id="VADKLIC"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="614" mass="70765" checksum="7279CFC99BAB41BD" modified="2023-02-22" version="1">MDVQRGHCWRCEKVLPQLTVPCSRCNVAVYCSTPCLDNDTARHSSVECRMFGPRRCGNCGKTPPNMKECASCSNEWYCSKECQLTDWKSHKPSCKEAKDSMKTLAEKLYQQRSATDKTSKDFPYYIGNIFAEDFLQLEGNELTSGVKEDSLARDYHILSVGCGNLRNTVLTAASLPDEYQGKLHITLNDYDPFVMARNVLFLFMFVRFADTDYIASSLTTIWYSLHISKRDYDLIKTTLEELIQMSAQQLHDVTKGLVTVLDEDLSSLCGIWGKWRSLECQRHKSTSINLRQQRMEQFQKANMAQNLSSYFKELSGTEKKKVQEWFDHALFFSTERKEKNMPFDNPTLTGREPLHTFKAPEESKFVYSVNADAFPYQEWDCLRVREHTPGSHSSPMVMYHKYVTNLLQKVKSLILQGRLLIQVSLANCLDFPNHHQTMNMSNYDRIFTSNIADYVGIPRLLHTFKPLLNPTNSFSVIVTEYMNWLRYIPKADTKLAFMLQQMSLKFLECGAAFSEDTQKNYPIGPSNLREYDDNTSYFLQYLRADIMAGGRGIPALQAVPTFMSVKKYHGMEMRNFRTGLNKLVPFMYRKNARDLTMLNGSDRAVEWCLPKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z914</accession>
    <name>A0A913Z914_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048237.1">
        <property type="nucleotide sequence ID" value="XM_038192309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z914"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192309.1">
        <property type="protein sequence ID" value="XP_038048237.1"/>
        <property type="gene ID" value="LOC119722267"/>
    </dbReference>
    <dbReference type="GeneID" id="119722267"/>
    <dbReference type="OMA" id="TIWKERC"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF24">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35839" checksum="077FC82EA063ECE0" modified="2023-02-22" version="1">MNDLLKPNCMYRLLFYYSVVVYYFEAYGCESGGVSFGDVKLTDLDYADDVAILAELMDIIHLALEAMNEETTPLGLSINWDKTKIQSLSDYIPAPTPPNMDNYQVVEKFCFLGNIVSSDCRSKADIQRRLGLATSALARLNTIWKERCLSRKTKLSLYNSLVLSILLYGSETWTLSAELERKLDAFDTKALRHIEGIYWQDFMNNKDLRLFTNQPPVSHLIRASRLRLFGHIARADPPMEPVLLLKGPAPNLPCPRGRPRLRWTDNLEEDLMALGLNLSSGWRLAQNRLDWKLRCGDAMSSRACEIDDDDDDDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z952</accession>
    <name>A0A913Z952_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038048174.1">
        <property type="nucleotide sequence ID" value="XM_038192246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z952"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192246.1">
        <property type="protein sequence ID" value="XP_038048174.1"/>
        <property type="gene ID" value="LOC119722199"/>
    </dbReference>
    <dbReference type="GeneID" id="119722199"/>
    <dbReference type="OMA" id="EMAFTII"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="337" mass="38212" checksum="252AB7D1F892C6B7" modified="2023-02-22" version="1">MERYETPDLRVTLYENGTSIRDIANEKVKDNEPKREDVDDPFYLYDLGDVVTKDKLWAKLLPNVEVFFAVKSNPDPVIIRLLIGLGKSFDCASKKEIKMVLDLGASADRIIFAHPYKQESHLRFAKEKGVRLMTFDTAEELQKVKRVHPKAQLVLRIRYDDSTATFNYGAKFGCRGEEVRPLLEIAKKLGLDVVGISFHVGSEASNPQIFSDAIRFTRPLFDIGTSLGFNMKLLDLGGGFPGRLYPKATFDKFADVITRALDEHFPASSGVRIIAEPGTFYTRSAGYLVANVIAKRVNKVDINERRERVSVLHTPKRYFSITHTSHQFYNMVLATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z979</accession>
    <name>A0A913Z979_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048199.1">
        <property type="nucleotide sequence ID" value="XM_038192271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z979"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192271.1">
        <property type="protein sequence ID" value="XP_038048199.1"/>
        <property type="gene ID" value="LOC119722225"/>
    </dbReference>
    <dbReference type="GeneID" id="119722225"/>
    <dbReference type="OMA" id="QDGGYGW"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="14"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="424" mass="45166" checksum="CAD1C53B292BD353" modified="2023-02-22" version="1">MWNSSRQDGGYGWVMTAIAFAANLILLGTFKSFGVFLLPVQESLQCSITTLGTVVAATHTTGFIFIPLMNRIAKTYGARRLAIAAGLLTFVCFVGTSTANNLPQFSVFVILWGVGVAMGYGPPIVEMLLYFPTNPALPIGIVGTGAGVGMMLCPPLAEFLIDIYGWRGAMLLFAALNANICVLGALIKPASSTYTALDGGSRESTRQSDGCTLWRCCTFILKRICEVLALDVLWFEPKFAMQALVSFLVGVMYSAWMIFLVPHAIARGINSQMASFLSTAGGVGTIVGRVLQGLLLHTGWVTALQFYTFLAFIDLVAFVLDPIISANYPGLVCVAFANGLGIPTMAVLFLQVAQQVLSKDLSVQGWGTLLVFFAFGELAGGALAGVTYEATGSYDTSFWMLGGVSGVAVVILVTERILHKCSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAG2</accession>
    <name>A0A913ZAG2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038047885.1">
        <property type="nucleotide sequence ID" value="XM_038191957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191957.1">
        <property type="protein sequence ID" value="XP_038047885.1"/>
        <property type="gene ID" value="LOC119721979"/>
    </dbReference>
    <dbReference type="GeneID" id="119721979"/>
    <dbReference type="CTD" id="7327"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="217" mass="23947" checksum="DF31028CACB2213F" modified="2023-02-22" version="1">MLMRRSGLPPCDQCVYVLICVICAASSVVEEVTRSCQISPHFYTTITMAGAALKRLMTEYKQLTLNPPEGIVAGPLNEDNFFEWEATISGPEGTCFEGGVFEAQILFPPDYPLNPPKMKFKSEMFHPNIYADGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDEREKFNQIAEGIVRKSLGLPPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBV6</accession>
    <name>A0A913ZBV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomerase RNA component interacting RNase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048531.1">
        <property type="nucleotide sequence ID" value="XM_038192603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192603.1">
        <property type="protein sequence ID" value="XP_038048531.1"/>
        <property type="gene ID" value="LOC119722470"/>
    </dbReference>
    <dbReference type="GeneID" id="119722470"/>
    <dbReference type="OMA" id="DCHEEQA"/>
    <dbReference type="OrthoDB" id="5983145at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753:SF1">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22140" checksum="31A0C7EC766E3ACD" modified="2023-02-22" version="1">MEEKGRVNAFANDGSFMEMFKRKMEQEKLRCGSAEEGSRNRPSATGEERDGKSRTLKSSAENARTNDPAGRETGQTETSTVTESRDDVVHRLSAQSVENEGAKESNEEQAVTVPDEQSTREGDKPAVASAPAQKKYSLLSHVGKRRDGKVSLKTGAVKKQRNTEAQESKDQDAWSKYMAEVQKYKAHVCGDEDKSRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDC6</accession>
    <name>A0A913ZDC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049514.1">
        <property type="nucleotide sequence ID" value="XM_038193586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193586.1">
        <property type="protein sequence ID" value="XP_038049514.1"/>
        <property type="gene ID" value="LOC119723080"/>
    </dbReference>
    <dbReference type="GeneID" id="119723080"/>
    <dbReference type="OrthoDB" id="10032694at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="995" mass="112787" checksum="C8C662F8F94221DA" modified="2023-02-22" version="1">MDQHIQFLGRLCRLCGKRCMSSVRCTKRCSDHAQKLLKTFQVNVHEDEANIHPPHMCHRCYCFLFHSKTRTAVHWPKHRRTGSCFVCTQFMQQSKPGRKKKCQTRTGRPRAPPAYSDHFNNLRPGPTIDKGNIHQFTALSNTADVKCRLCNQLLDNAVETPCMHLFCCECLIVHFKDAGQSIPCPTCQAPVHYRNVTSPREYFASLYSSLAMQCTVCNILVTLGDVKLHICRGVPRPSLRHVDQPVSMHDHRYASQLPNDAISTVDQSILTHDHGYATTAKPPSDVVRILHRPLTAPVTPQMEELGTHILKTKLAQTEDRFLVKYKTGGLPLTLVCIPQARKSSKDAASLSVRNRSKILDKIRGLLSMDAKELQQQDELKLSSMKDELESILKDLKLNSIRIPAMKLLAVKTHLGISWTRIRELKKWLKGYNILTEGENVLRRQQNEVIADNLITDSLPLSFRDEIDGGVVIQQAPYVGVKCLVAKIKQQLDQYQKYQELTWHEGTIPHDEIWVKIGGDKGGGTFKQMIQIGNVKHPNSLRHTIIMSVFAGEDTRDNLKTGLQRFRLQVPELQSSSWQGCKFRLFMFGDYEYICRVYGITGANGRHCCLYCDITKDGMRLPLAERPALQQRSLETLTYDLQRFRVHGAHLTKAKEFNNVIDEPMFAIPLTQVCPPGLHISLGLYLKHFNSFEGACHDLDMEVAAVLAEKDHEEWDSQVLGSRYQTLISVLKQARCLEQQARALDEELKLMEEQLTDTILTSEEESTDMQDYISATTKLVKRQKKLFEEANALRDQAALKPGQGPLAGQLDITLQEFRVKRQAFDGKSFVGNHVHKCCKKENIKLLTDALVIKTQQVCASLVPAAASIAAKYAQLFHLFGTCHRMYNSASLLDDSAIDALDQAIKDYMNFFRGEFPSESIPPKMHLLEDHVMPWIRRWGFGLGFHGEQGGESVHSHFNCLRRDVRGISAEVDILKSVVKSQWIMTSPAHAPPITFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDJ0</accession>
    <name>A0A913ZDJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049843.1">
        <property type="nucleotide sequence ID" value="XM_038193915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193915.1">
        <property type="protein sequence ID" value="XP_038049843.1"/>
        <property type="gene ID" value="LOC119723340"/>
    </dbReference>
    <dbReference type="GeneID" id="119723340"/>
    <dbReference type="OMA" id="MIMDIAH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="379" mass="41419" checksum="8BA7BD5CC8BD4109" modified="2023-02-22" version="1">MAAFVKPDDFSSPASIKIPATNRILSGIRNSSFTSPAARSSCSSLDSPLSGRVTAAIPPSPFMERIGYGTGVSVYLFQRGSKSDGSGLSPWAIKKTRARTCNNGNADNKQDKVEKMLAKEAQILKELKHDNIVGFRAFSRNVDGSLCLSMENGEQSLCDLIERRDEEDLGPFPASNIYHVALALARALNYLHNEKHILHGDLKSGNVLIGADFQSVKLCDFGVALKLEKDLTCTQDADNHYIGTEPWSAPEVIQEEGAVTDKADIFSYGLVLWEMMAVTLPHVHLLSNSIDDSAEDESFDESLYEARYQAALGTRPPLPDYPLSPAYNFAISLFLACTEDLPAKRPSASFIVELLESIPVPSDHSAADFIEDKENVPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEA7</accession>
    <name>A0A913ZEA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050122.1">
        <property type="nucleotide sequence ID" value="XM_038194194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050123.1">
        <property type="nucleotide sequence ID" value="XM_038194195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050124.1">
        <property type="nucleotide sequence ID" value="XM_038194196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050125.1">
        <property type="nucleotide sequence ID" value="XM_038194197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194194.1">
        <property type="protein sequence ID" value="XP_038050122.1"/>
        <property type="gene ID" value="LOC119723506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194195.1">
        <property type="protein sequence ID" value="XP_038050123.1"/>
        <property type="gene ID" value="LOC119723506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194196.1">
        <property type="protein sequence ID" value="XP_038050124.1"/>
        <property type="gene ID" value="LOC119723506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194197.1">
        <property type="protein sequence ID" value="XP_038050125.1"/>
        <property type="gene ID" value="LOC119723506"/>
    </dbReference>
    <dbReference type="GeneID" id="119723506"/>
    <dbReference type="OMA" id="TIMTYAV"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324090" description="Sodium/hydrogen exchanger" evidence="12">
        <location>
            <begin position="38"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="105"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="756" mass="84250" checksum="EA3A877EA6DA195A" modified="2023-02-22" version="1">MRVTMATSRQHPFRVTSLFLPVLAILLVSQLVLTATANENTTSPVITHEAVDDTHGDNSSDEHEGGDAEPHRGHGGVHVASWNLKYVQLPLTVTFFALFVGVAKIGFHHADFLSAIFPESVLLIVLGVVFGGIAYATKQTGSFDSQTFFLYLLPPIILEAAYSLHDRTFADNLASILIYAVVGTLLNTFLIGLTLYGISLTGAYGNSFTVGLIECLIFSSLISAVDPVAVLAIFQEIHVNQVLYFLVFGESLLNDAVTVVLYNMMNSFLSLETIPASQIVLGFVSFFTVSLGGAVIGFLVGILTAFLTKFTKHVRVVEPLAILGMAYLSYLLAELFHFSGIISIICCGLAQAEYAFDNISRKSSTTVTYFTKMLSTTTESIIFLLLGQTLWAEKHQWNTGFVLCTLLFIFVYRVFGVVVITFVVNKFRIGKINKEEQFIMSYGGLRGAVAFSLVATLLPEDVPARNVFVTTTLVVILVTVFVQGTTIKPLVKLFRIKRSGQEDPTVALAIHQTVIDYVMAGIEEVIGHKGHNYVRMWIEKMNTHYIKKYLQRNPTSWEDEVMKTFEKVTNHDHHNHIFKLSRGEECRKNSETEIEKFKPMLTRGDSYFDSIRRRHTFKKTPGGEYMAISDKATPADVAGIMKKNPRNALHEKYDKNLLNDDCQDLPLLMRQRSTEHVLAQERITAMRAANKWRRAVRSSKSGGNVPATIAEENERKGDREQGEEDIVFLEDEGKSKEPIVKIEPEIIGNDDADTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFK7</accession>
    <name>A0A913ZFK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050234.1">
        <property type="nucleotide sequence ID" value="XM_038194306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194306.1">
        <property type="protein sequence ID" value="XP_038050234.1"/>
        <property type="gene ID" value="LOC119723583"/>
    </dbReference>
    <dbReference type="GeneID" id="119723583"/>
    <dbReference type="OMA" id="DERMAIG"/>
    <dbReference type="OrthoDB" id="6134084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="36167" checksum="A1121B0BAE171B63" modified="2023-02-22" version="1">MATLLSAFGGSSVFKCATNLLVSIVACVAATVACASSWQWREATYAAQEHRALVGHSIGSHTGVTRSNCAVLCLREGDIQCRSFNYDKTGRTCQLNGARVEEFPESLVEDVDFSYYGAQLEEANTDFQELQTTPAPEWQLVFKGVAGNGVKMYDMWTAATWNEATLGVGGSWRDDSLYGSWNSGDLDIGRVKLSLYDSSNVSRVELIFNGTGSDVSSWFSKNRLISSPWQDLISTATNYFSIEGDVNEERRFYINHNYGGCPGDKGWLVVTDSQMLTDCQYERPSAEYPYPIILYSNTAGKVVWQDVLTTGADTVGRAAYLTIHINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFZ0</accession>
    <name>A0A913ZFZ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049910.1">
        <property type="nucleotide sequence ID" value="XM_038193982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFZ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193982.1">
        <property type="protein sequence ID" value="XP_038049910.1"/>
        <property type="gene ID" value="LOC119723375"/>
    </dbReference>
    <dbReference type="GeneID" id="119723375"/>
    <dbReference type="OMA" id="YGVMYIA"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663823" description="Membrane magnesium transporter" evidence="9">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="117" mass="12903" checksum="0A26573D406C0A47" modified="2023-02-22" version="1">MATFSGFILAVGFLGLAHAGYSAAQHRTYLRLTEQEFTRLPIDIVCQGLVSLLITIYGVLNIAGQFRGIKAMADMEKKSFDTVGNRPSFFMFRHRGQAMFGLNPTGNKNVETLEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIX8</accession>
    <name>A0A913ZIX8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051005.1">
        <property type="nucleotide sequence ID" value="XM_038195077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195077.1">
        <property type="protein sequence ID" value="XP_038051005.1"/>
        <property type="gene ID" value="LOC119724151"/>
    </dbReference>
    <dbReference type="GeneID" id="119724151"/>
    <dbReference type="OMA" id="FHINGHR"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="433" mass="47678" checksum="3582159BBCA49574" modified="2023-02-22" version="1">MEEESVKKTQGMEEAEMTKPTNKRRKRGSVQDEARKETKGDDVTNSDTGDNPPAKKKKVWPAKYNKGPFICAYCSKKFRGLLDLTRHERTHTNEKPLLCPECGMGFAGDSSLRVHLMIHRDDRPFACPTCKAAFRSKPALREHMVVHTDLRPHVCKICGTGLRQRSSLKKHMRIHTGERPHKCEICDRAFSKLETCRLHQQRHADPNSRVNRIPKEPRRNRNRVRGGRKFLPQRVRWEITRDLCRQVDNSQTPAAPLTNLPTNMVSVTTPLNISPLTEGTSMTSGSNTNHVTSNTPASTGSTVPTGDTRNGSLTPSVVQAAAKSTNGTNVALNGPTLSNVPTAPIQGTQVYVAPPFTTHATSSLPGSIITSDNVTPVDFHKTGGRMPIQTLTSDSPVLVNARQVVTFQFTPFMVIKTPFGDLGSNTASSETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJL8</accession>
    <name>A0A913ZJL8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052012.1">
        <property type="nucleotide sequence ID" value="XM_038196084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052013.1">
        <property type="nucleotide sequence ID" value="XM_038196085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196084.1">
        <property type="protein sequence ID" value="XP_038052012.1"/>
        <property type="gene ID" value="LOC119724835"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196085.1">
        <property type="protein sequence ID" value="XP_038052013.1"/>
        <property type="gene ID" value="LOC119724835"/>
    </dbReference>
    <dbReference type="GeneID" id="119724835"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="215" mass="24369" checksum="DD7D0427C8A3C722" modified="2023-02-22" version="1">MLATIFSSFPQIYILVLLIQKTLETYAGMFFIPMATRLVNDESAKCRKITALAIRSLLQKLWVEKRDELFTMATHWLHDNNPAHQCLSSQLCGIFVDAEEAGIQRRLDDILPQIQEHIKPDGLQKDGMSAMETDDTSMEERHTDHMLFNLLSALAKMIKHCSIIGNKAYTDTLNAIWDPSNLIFSIRTPGCVWFRPSSLETCLLLNNQTSLPGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLA2</accession>
    <name>A0A913ZLA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052109.1">
        <property type="nucleotide sequence ID" value="XM_038196181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196181.1">
        <property type="protein sequence ID" value="XP_038052109.1"/>
        <property type="gene ID" value="LOC119724884"/>
    </dbReference>
    <dbReference type="GeneID" id="119724884"/>
    <dbReference type="OMA" id="AYVWAEL"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37224" checksum="493BCBC7654F01E2" modified="2023-02-22" version="1">MLRALGSRMREAASVASLAELQYHPSLAKLYSTTPTSAKAPPITKISSSLTLQKAPAITDGQESKQRPLVLILSWLLAKQRHLDNFVSFYTSRGCDVLTVRIRPLQIMLPTRGSKVIAKDVVEYLQREEIRDRKILVHSFSVGGYQYSEVLQQMLAVQSESKEITSRIIGQIYDSPVDFNEVPIGMSKALLKNPLLQKTLHMSLDSYLRVMYRPVTQHYLRSSDVFFHNPVPAPSLFFYSHTDLVATADASQRAIASLQNKMGYKNVYSKSFEDSPHVSHMYKHRDEYMEALMKFLEGIEYFNEALEEHKDKPDLVSEDMKGKVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLC3</accession>
    <name>A0A913ZLC3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051895.1">
        <property type="nucleotide sequence ID" value="XM_038195967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195967.1">
        <property type="protein sequence ID" value="XP_038051895.1"/>
        <property type="gene ID" value="LOC119724759"/>
    </dbReference>
    <dbReference type="GeneID" id="119724759"/>
    <dbReference type="CTD" id="81567"/>
    <dbReference type="OMA" id="TKHQTLC"/>
    <dbReference type="OrthoDB" id="71336at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765320" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="144"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="256"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="47134" checksum="3B0137B9AACF90C8" modified="2023-02-22" version="1">MEFRTTSVMSLLLPVFLSVVLMSCVSADNDDHGEVKNEYNELMFNHAIGKSAHFIMFFAPWCGHCKKLAPVWDQLAERFNTDESVPATYAKVDCIKETKVCHENDVKGYPTLKFFNPGKQPAKYTGKRDFENLERFMLEQLDKKKESVPQPPEAKHGLYELTEDNFKGHITEGDHFVEFYAPWCGHCKRLAEPWQQLAEGFSHNEAITIAKIDCTAHRQVCREHNVNNFPTLKYFRDGKEIDTYKGGRDHKSLKEYVTSKMAPPSTEAPPTQDIKKEEKKVEEKKIMDGPAGQTEPRESKVVILTEDSFPEGISKGLTFVKFFAPWCGHCKKLAPTFEDLARKVEDKPGLTAAKVDCTVHKTTCSKHEVKGYPTLMLFKNGNFVEKYSGSRSLDDMYSYMLRKLKESQKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLK4</accession>
    <name>A0A913ZLK4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051936.1">
        <property type="nucleotide sequence ID" value="XM_038196008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196008.1">
        <property type="protein sequence ID" value="XP_038051936.1"/>
        <property type="gene ID" value="LOC119724792"/>
    </dbReference>
    <dbReference type="GeneID" id="119724792"/>
    <dbReference type="OMA" id="TWHEWIS"/>
    <dbReference type="OrthoDB" id="6094239at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="142" mass="15993" checksum="BA613CDA485EEDDA" modified="2023-02-22" version="1">MENGTIQDNRITASNIRSCCPASQARLNNYIGWQAYYFTNAWIEVNLDEPTVVSGVITQGHPSHDYYVKKYKVSYKKQSSSDYEHVTDGNGNNKVFIGNTDGDTPVTNLFDESVVATVVRIEPTGWYGYVALRLELLGCRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLU5</accession>
    <name>A0A913ZLU5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin receptor substrate 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein chico</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Bindings to phosphatidylinositol 3-kinase and SHP2.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052031.1">
        <property type="nucleotide sequence ID" value="XM_038196103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLU5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196103.1">
        <property type="protein sequence ID" value="XP_038052031.1"/>
        <property type="gene ID" value="LOC119724842"/>
    </dbReference>
    <dbReference type="GeneID" id="119724842"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF13">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="12">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="668"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115024" checksum="BCC4C2433BFB9902" modified="2023-02-22" version="1">MSSQKENIPGPGDGTDIVKCGYLKKFKTMRKKFFVLRCESSSGPARLEYYDTEKKFRAGALCKRTIDLKTCFNINKKTDSKQKHALSLYTRDDCFVVVAEDENSLNEWLQELLLQQQAENDGMPMPAFEHVWQVTVKPKGLGSSKGLSGNYRLCLTTTTVNLVKMNCENEDLEFSLSAIRRCGHSDCFFFMEVGRQSVTGTGEIWMQVEDTVIAQNIHEASLNAMRSISQQEEEMRPRSQSSGNTSETKPNSTRRQVATLGPSWRTRCESMPAQNRPRVARSRIGSESEESLQEEPSPTSASLGTTGTSSLLSSVIRPRTQSEGEGNHTARIGGSSLLKYGLKTRPRTASEGESHFRSGRTPESPTKARGRFAMPQRTGSGSLRPSSMHRVVQPISNSPPIPNSPLSESPLGVSEDRFLSYPQPLHASDPNLSDEFPGYGTSPSDHLLARFSGSGRSRTPDSPTRTPIREESVEFTDEYMNMAPSGASKAVLTVPVPTRQPLHHRTMNTQGRSPSPEHVYALLQPIHLTISPPSPQSPPSPPSGVHCSPPSPLHFPPPAPPDEDQSYMSMTPMSRSGSRGSSGYAPPTQAPPQLTQRSASVSGRLMTVPPSQDEGYMMMAPRKAAQKRGSTGSREALKRGNTTEGRDGLKPPTADIDQAYTMMQPIPKHHGNSTVHDGTATKASGIAGNVPKAPTANSHREGKSRGSFSSPSSTKPLSFEAKMKPSEILVRSMSDSKEPILDTYMTMAFQPKNSKPKSPEIAKPGNVSPSLDNIDENDNPKSSYVNVSLPEASPKPKQPDSDYTFMVPSSRPANTRKDSDKGQSQSAVESLLKGSRKAEASRGSEYMNVDFSKGGVPGGELPVRPVPPIPARVPAGKREDGEYMNVEPGLGVRPHSPRSPTSPPVLPQRVVLPPRNPSTPPSLSPSLSGNGAGRRAADLKTGMEDLNLNEGSSPTSIGSAGSLTSGNKSCEPSPGPPSRHSSCRSSQTSLADRELNYIDVDIGQPDANSAPITLERRARSPFTRRAAEEDKSDKPTNYATIDFTKSEGLRSATTTRENRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM28</accession>
    <name>A0A913ZM28_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052121.1">
        <property type="nucleotide sequence ID" value="XM_038196193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196193.1">
        <property type="protein sequence ID" value="XP_038052121.1"/>
        <property type="gene ID" value="LOC119724890"/>
    </dbReference>
    <dbReference type="GeneID" id="119724890"/>
    <dbReference type="OMA" id="YLEYHMK"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="324" mass="36600" checksum="DBE320FD04E7EAED" modified="2023-02-22" version="1">MLRAAGLGVHRSSLASLAEFPWQPNIVRCYGTPASNKPKTPIIKINNNLSLQKAATSSSSDSPKERPLVLLLSWLAAKQRHLDNFAAFYLSRGCDVLTVKLRPMQLLLPTVGTQVIARDVVNFLQSKEQRGRKILVHGFSVGGYLYGEILQRMLASQTESREITSRIIGQIYDSPVDLQNIPVGISKALTQNRLAQRSMQGSLQVYLRVMHSAATKHYYKSSHMFHHNPVSAPSLFFYSHTDPVGTAEANERVITSLKTVMGYDNIYSKAFEDSPHVSHMYKHRDEYMGTLKAFLTKIDYFKEALEEYRELEDFVGEDESKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMP4</accession>
    <name>A0A913ZMP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_038052326.1">
        <property type="nucleotide sequence ID" value="XM_038196398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196398.1">
        <property type="protein sequence ID" value="XP_038052326.1"/>
        <property type="gene ID" value="LOC119725032"/>
    </dbReference>
    <dbReference type="GeneID" id="119725032"/>
    <dbReference type="OMA" id="YHTDENA"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="231" mass="26208" checksum="3ADCE4BF227F48DC" modified="2023-02-22" version="1">MDHGVPHLHLISIVQINFNQDFVISGGGLPGTQYKVAQLHYHFGSTYGQGSEHALDGRHYEAEMHLVTYDTQYPSFAEAVKHKDGLAVFGGMIEVGLFDNALYEDFLSDVEDIEYKGDSSDFSLPCCLVDLLPKDFGDFYRYRGSLTTPHCNEVVIWTVWRTPVRLSAGQLGVFRSLYHTDENAVTEEPLANNYRPLQPVNGRDIQYNGEHNYRWVLDFEHSLLPPPPIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP32</accession>
    <name>A0A913ZP32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053497.1">
        <property type="nucleotide sequence ID" value="XM_038197569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053498.1">
        <property type="nucleotide sequence ID" value="XM_038197570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197569.1">
        <property type="protein sequence ID" value="XP_038053497.1"/>
        <property type="gene ID" value="LOC119725949"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197570.1">
        <property type="protein sequence ID" value="XP_038053498.1"/>
        <property type="gene ID" value="LOC119725949"/>
    </dbReference>
    <dbReference type="GeneID" id="119725949"/>
    <dbReference type="OMA" id="FMEARCA"/>
    <dbReference type="OrthoDB" id="5989976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF4">
        <property type="entry name" value="CASPASE-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="672" mass="73497" checksum="C20A0328D9316EDC" modified="2023-02-22" version="1">MANPAITNYRSLLRDVASGLSKKDVEEMAYTLGFDAAADITSGTHLLREMERQDKLDEDNLDDLKRLLEDHKRNRLAKKVQEFQAAQKSAMEEPLSKTWPTSTFNQQKAPAADKPRTQSITTEPAMNAQAVPPFPAGMQHYYPTPQGVASLSYQSPMSMQQQVSVDQYAVYPQPLLQSHPGEGHPMQDRNPTHQPVQMANHYYQASQTGNPYQQGLSTPGYAPCVNGGSVQQMPNDQDLQNTIQQLQEKLRLQTLLQNSGNQAPTAVQYTGTPGSQPNIGTPQAEPRSRIQSYPQASGVPQVQGYMPNNAPPGHAKVSAIKSAPCAMSAAGQNLQNFSPNVTEPEASLKGPHQSHPKIENQTWNIPVENVAGEGMPKVNGQQMEKGNVMTGTSSIGGQSPSSEIKRYNAANTAATDGTYQTGRVRADSVENNRNSTTIAAHPISTNSIGNAERQLLSEYGTGKQLYDHRRIDLFENGPYQVKIQEGVHVLTTEGGHVILRYGTNYTIKLFNNDQRLRCSAVVCYNGRFAGDWTVDPRGSIVIERPATEERKFCFIDPCSAAAGSGVTDGDPNNGLVRVVFTPEKSKTGPWNDISRGFGNFGSEPEVDYFGTDDAVPSVNDVPRSLVGPSHSDWQPGATILQGTSSQQFTASEHFQLDESRKKVIEFKLVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPG6</accession>
    <name>A0A913ZPG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RFX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Regulatory factor X 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053264.1">
        <property type="nucleotide sequence ID" value="XM_038197336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197336.1">
        <property type="protein sequence ID" value="XP_038053264.1"/>
        <property type="gene ID" value="LOC119725769"/>
    </dbReference>
    <dbReference type="GeneID" id="119725769"/>
    <dbReference type="OMA" id="TCFVANR"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000211">
        <property type="entry name" value="Regulatory factor X, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF28">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="11">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="871"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="964" mass="107556" checksum="021AEB21179AEEBB" modified="2023-02-22" version="1">MMKLNGRAASPARTVDSHAGAPLKRTVSVISRNHAEPAKKSARTEEECKLTKLELTPILTEDEGETFPSDESEEEEDEEEEEETRDKKHERESTSSSQPKRSVAQMMKDKKKQTSLTLHWLEENYCMCEGVCLPRCILYAHYLDFCRKESLEPACAATFGKTIRQKFPHLTTRRLGTRGHSKYHYYGIGIKETSAYYHSVYSGKGLTRFSGARLNNEGGFTRKYSLASKTGTLLPEFPSAASLVLPYSIPKEKVETLLMMYKTHCQCILDTIINSNFEEIQNFLLHFWQGMPDHLLPLLDSSVIIDMICICDSILYKTTVEILIPATMQEMPEGLLADIRNFAKHWEQWLCSSLEHLPEAVSQSKLPVARRFVQSLRRQTSFLHLAQTSRPVLFDQQLIDQMISDLDKVDLHSIGSQALLTASTDESDMELNAEFLKEFKELLKKQATVEAFTEWLDQVVESKVIKPGKQNGRSMKKRAQDFLLKWSFFGARVMHNLTLNNAQSFASFHLIRMLLDEYILLAVEQQFNTEKDNDLQNRLEKHMKVAGKNDPNNPQRPLSNQPGTCFLANRNNIMSRPNQGFSDQSPVKREDYVERYPGGTYTGHTVIAEKDSYTIPGHYGTQPSMPSPGSAARSNAMLTPPISPIVVNPMRNSVINQGHVGVNARNPTNPSSLVPPAMHHGAYPYLGHVGQNQDPYSSGRAQGYLGPYQGGGCYPPAMFHSNYSPAAYHSKNDADAAPTYPYADPQYRDDGYYNSCAMGTGHHVEGGVIQATGAVHGSSAFNVVGNIPSTYAFTNGYQNAGYYSQGAYNHEHPGHKDVEHVSVISSTHAQRVRPERGHAQFNEINDPLNILDRPAVTRGNKEDLIYGVTSQASCHDPTGNQASQSPSCNGVRRHPENLIGQSDYIPVPGVSMYHDTTGEIRPIVSNQHSTSHASHHPQPNGTPIENNEQGSSLPPINTVFNIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPJ3</accession>
    <name>A0A913ZPJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053294.1">
        <property type="nucleotide sequence ID" value="XM_038197366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053295.1">
        <property type="nucleotide sequence ID" value="XM_038197367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053296.1">
        <property type="nucleotide sequence ID" value="XM_038197368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197366.1">
        <property type="protein sequence ID" value="XP_038053294.1"/>
        <property type="gene ID" value="LOC119725791"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197367.1">
        <property type="protein sequence ID" value="XP_038053295.1"/>
        <property type="gene ID" value="LOC119725791"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197368.1">
        <property type="protein sequence ID" value="XP_038053296.1"/>
        <property type="gene ID" value="LOC119725791"/>
    </dbReference>
    <dbReference type="GeneID" id="119725791"/>
    <dbReference type="OMA" id="QHEPHEM"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000608">
        <property type="entry name" value="zinc finger protein 286A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000564">
        <property type="entry name" value="zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="802" mass="90350" checksum="BAA08AE54C020FB8" modified="2023-02-22" version="1">MEEADQSASESQALEKTTVESEVTDENRIDLSVAVETLAGEENPVDGIASQGAVVEGLPLQSEDDLPHLTAQYQGVDGYTGGESVEGLPSHDESVDNLPTESQVIEGLAPQDQSVDGLPLQNESVESLPTNENTVETYIVQEHSIDGIPGQQHVVTLAGPDHSVGSLPTQTQAILTQQVSHHMDPNHQIDGNDQVNIDSSNVVISTVEVPLGVSHYHDASHMDAQQVMHHIDPNIVEVSLAEAGIDSTISVHHEQHEMDNNLAGVQLNVDGYHVNQPVVITQDGQAMGQDGNPMNVEILSGADSTMAIQQVSQSYDPNDDSQPRYVHIITAPDGTMNIQQDSQEIPLAVEILTGLADFMNSQQMQEQPQLMDQQMVDAIIKHKKHKQKKDKGKDKDKPKKNKKHKKSKRYRLTEDAQWMCEVCKKKFGSKANLKVHMICHSSERPYECHLCHKKFKRNRYLIDHRRTHIGDRPYFCSYCHKAFAKKSSLNCHERVHTNPFMCSICNKGFSEKRGLIIHVRSHTNEKPFVCPICNKAFTSKNPLLRHERSHSGLKPYICNVCNKAFTRKTSLHDHERVHTDEKAFSCESCMKTFAARSSLRSHLNKYHPGERPKVPKLVKTLNIQPPDTSQEARTRNYYNRKPAKGYDNLERPYVCKICNRGYTRQRTLTVHERVHTNPLLFACKVCGNVFAEKRSLVIHERVHTREKPYNCELCDRAFSSRTACKRHEKSHTGLKPYTCKTCGKAFTRGTSLREHARIHSDDKAFSCLKCGKVFGAKSTLRSHDKKHHANEKPFEILKIIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPV9</accession>
    <name>A0A913ZPV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038053752.1">
        <property type="nucleotide sequence ID" value="XM_038197824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197824.1">
        <property type="protein sequence ID" value="XP_038053752.1"/>
        <property type="gene ID" value="LOC119726216"/>
    </dbReference>
    <dbReference type="GeneID" id="119726216"/>
    <dbReference type="CTD" id="11056"/>
    <dbReference type="OMA" id="EMAHSIM"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000906">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="228"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="417"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="72589" checksum="9AC7BFF992F74881" modified="2023-02-22" version="1">MKRHCWWRPTVLHKNKKRGFKMATSMDLFKKLGAGLKFDLQRFRSDAEKFQVIKPTSKKITKQEVERALDIFGSAKSLPKSPQDGHNVNAHAATQSHNKTNVEAKKRKPEEEHSASTKRKKEKIGGKGTEKAETTEDGGGLQLMSSLQLKIKKDENKKQSADKLEQKRREEVNAFRKQHKIHVWGTDIPDPVGTFHALQNEYSLHSDTIENIHRAGFVQPTQIQMQAIPVMLHRRELLACAPTGSGKTAAFILPILAHLKEPKKKGFRAVVVSPTRELANQTYREFQRLAEGRGLRVHLIESTAKAVKKFGPESSQKFDILVTTPNRLVFLLNQEPPGIKLNNVEWLIIDESDKLFEEGRAGFRDQLATIYRACDSTHVRRAMFSATFTHDVEQWCKLNLDNVVTVTVGQRNTATELIQQELVFVGGEHGKLLAVREIFRKGFHPPVLVFVQSKDRAKELFQELIYDGYNVDVIHADKTQMQRDNIVKSFRSGKIWVLIATELMGRGIDFKGINLVINYDFPTSAISYIHRIGRTGRAGRPGKAVTFFTEDDSVHLRSIANVMRNAGCPVPDYMLQLKKLTKGKRKKLERQPVKRDTIRTLPKQDLDKAKKKREIIKKGLKKKQKKSLNRKGSTVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQT5</accession>
    <name>A0A913ZQT5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053739.1">
        <property type="nucleotide sequence ID" value="XM_038197811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQT5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197811.1">
        <property type="protein sequence ID" value="XP_038053739.1"/>
        <property type="gene ID" value="LOC119726211"/>
    </dbReference>
    <dbReference type="GeneID" id="119726211"/>
    <dbReference type="OMA" id="KGICFAT"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF13">
        <property type="entry name" value="SI:CH1073-145M9.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24549" checksum="01807D723F17BAC5" modified="2023-02-22" version="1">MSNLNIYFYVPNIIGYVRLLLLLLAWFCLRYPPWFITFYLSSFFLDFVDGAVARRLHQTSAFGAWLDVAIDNLGRGMLWCWLFRWGYFVSALEWCTFVCTHTAGWQWKSNYGQAPWLIKNVMADNFRSPIGMYAILSLNLLPLWFYFCHYGFYGSSIFLPMTVQYIGVAIFSAGRAVCSVVEGYCIWAHIQQMVSSEVSQKSTGLGEVQTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQZ4</accession>
    <name>A0A913ZQZ4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054198.1">
        <property type="nucleotide sequence ID" value="XM_038198270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198270.1">
        <property type="protein sequence ID" value="XP_038054198.1"/>
        <property type="gene ID" value="LOC119726542"/>
    </dbReference>
    <dbReference type="GeneID" id="119726542"/>
    <dbReference type="OMA" id="QCLCCNS"/>
    <dbReference type="OrthoDB" id="10043348at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="820" mass="89708" checksum="AE5583C929A052C9" modified="2023-02-22" version="1">MSVQSPRTGPCKSDTDPGVAPGPGPGSDDSTLTQTPTTGGDTTSGAAADCSMATDSGGGEDSPSDYNKRKYHASKMDLNLKILRDQMANLTSSGSSLSRQLASVQRNIQEIKDDDDDGEEADSEYESEDEQKIGSTRDALDTEDDVNKMSDLEKDYSEPKIKRSVSTSSRSKKSKTAARDPNPNEVGHDGSQARHGRSNSRQESVESYQDSDSECSQCLCCNSMASYSSTPWRYISRGEGSTMDEDSDSSEYFTDDSEYSTTTSNMPAVDIHKRLSPFYCPSDHGESGSHGANEEGRFDDADQEQVVDHRMSPLGCESPRKCSSQPELSSMAGKSDKMAVETDKPQSEEKAGETVETQEGEEKAPKASSLIGIFKAQESKAKQEEMASVAKAKRVEELRRKNSDIRLKNEQKRRAEMEEKLKNKPNVDTDSPKSSPLVSEIEDGEKVNIKDRISCFEGQKKTKDEEDTDKDGLKNSKKSPNVEKGTNTEQDSMQQMPDVIPGVTDEKLSQEEPTKTQGDHDQHKSHKSKHKIAKTTIEIPVSCLPEEIIHPEPGMPSDHPTMMTFQVQPGDVEAMSGPILVSRSPKPKRRMSKTIVRLSSTDASPSSMSESTLVADTDKVRMGAKKPSGHSHSVCPHCQKKNKPGESKRVVKVLQLQPVPESPQLSPVSTMVGDSAHVFQQPGGRIIKMIPSKTPNVVQRQESSKDGVVFRFNMGMPENAPLQVGDYIRIPIQPQQQYPPTQVRHVQQGSSGGLVIRTEGQPRRQREVITFRQSSSRPSAGNIRVQQRQSPTSGVTVHTSQPGVRVMPSEGGGVKLVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRA8</accession>
    <name>A0A913ZRA8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053924.1">
        <property type="nucleotide sequence ID" value="XM_038197996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197996.1">
        <property type="protein sequence ID" value="XP_038053924.1"/>
        <property type="gene ID" value="LOC119726340"/>
    </dbReference>
    <dbReference type="GeneID" id="119726340"/>
    <dbReference type="OMA" id="SHYISIC"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037571926" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62809" checksum="C418B5966BE19ACA" modified="2023-02-22" version="1">MSPSLSTVLLVALLSQLFVLPALTSSKGDDTPDSKKYKFLYFASIMGGSHYVALARSGRALVQQGHRVVSLVGSSNSNRSWQRDADVFSFVVFNSTYTKQNRTDVMDNISKVIVKGHHNHFFGPFLNSANLTGKLNFMDMWLQECDDLLGDSTAMERLRKEKFDMLVVDDMIPCGPLLAQTLDIPFVHSSVFFVIPSKHGHWTGLPTYPSYIPERNMGLTNKMTFLQRVQNVLVHYLYGLIHFRTRMGICNFDGYDQLKVKYNIKPEISTLESYKQALLYFLHGSFALEFARPMQPNTILILHHPGVNGNQTLEEDVAQFLDTAPSGVVMFSMGSFVTMMEREQAQMFADAFAMLPHRVLWQSGADLSGLRLGNNTLVAKWLPMTQVMEHPNVRLYVSQGGALTLNEALWAGLPIVGLPLAEDQMDNLVRVEAKGVGLKVDIASMTPRTLSQTIGRVMTEPKYRENARRISEIMRDLETSASPVDTMARWILHVTLFGGDHLRPAVQDLNFVQRNLLDVYLFLAVVLALVTWINVTVSSFCLRCMCCKGRNKNHLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRH6</accession>
    <name>A0A913ZRH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053755.1">
        <property type="nucleotide sequence ID" value="XM_038197827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197827.1">
        <property type="protein sequence ID" value="XP_038053755.1"/>
        <property type="gene ID" value="LOC119726219"/>
    </dbReference>
    <dbReference type="GeneID" id="119726219"/>
    <dbReference type="OMA" id="QYAQSFA"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27182" checksum="267569A4CA188C1C" modified="2023-02-22" version="1">MRSVLVTGANRGIGLEFVRQLLQLEEPPLYVFACCRAPEDAEALQSLTKDKQQLKIIKLDVTDEATFPEAVATVDRAVGEEGLGVLINNAGVLQRGGTETTSMADMEESYRVNVMGPLAVSQAFLPALKRAANRACTDSPKQLSTDRAAIVNITSALGSFQLCTSSRYIPYRTTKAALHMLTKCMNFDLRPQGILVVALHTGWVQTDMGGKNASLTPKKSIQGMLRVLARLREKDAGKAFTWEGKLLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTF4</accession>
    <name>A0A913ZTF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054882.1">
        <property type="nucleotide sequence ID" value="XM_038198954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198954.1">
        <property type="protein sequence ID" value="XP_038054882.1"/>
        <property type="gene ID" value="LOC119727089"/>
    </dbReference>
    <dbReference type="GeneID" id="119727089"/>
    <dbReference type="OMA" id="RRFWRIS"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="18">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="16">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="16">
        <location>
            <begin position="402"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="16">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="15">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="495" mass="57584" checksum="9E2FE63388FE75A7" modified="2023-02-22" version="1">MSAKLGATRVGQVIVLIFLVGVIFTDWELCQAAPTQEKAVVSVTGLHQELTPWSDLPSSQDGQASAPRKFQEDDTTLESSKNLPRDDRTNHVSTRQARGKPRCGVPDPIRLEDDDHSVNRRQRRYSVDWTRWKKKHLTYRILNYPYYYRMTEDQVDDSIDRAFKQWDDATPLTFRRITYGYADIHIKFATWHHDHCPYEFDGVNGTIAHAFVPNGLHGDLDGDVHFDDSEVYTYYGDEGYNLFQVALHELGHSLGLQHSWTEGAIMAPEYSGYMPDLKLQEDDIRAAQLLYGTLEPSNYGDPDSHCNKGYDAATMIDGVLYVFKDRRFWRISRPGKLIAPSAGLPIRKRFFKLPRMIDAVYQRPQDGHVVFFKGPHYWLYKGRRPLPGYPRPISELGLPDDIDAVVMLHRYNTTYFFKDHQVWRFDEEYQSVEYGYPYHVLDVWEGIPPFIDASFDYTDGYTYFIQGKTYYRYNNDYRNADPGFPRYFGTDFMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTK4</accession>
    <name>A0A913ZTK4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054530.1">
        <property type="nucleotide sequence ID" value="XM_038198602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198602.1">
        <property type="protein sequence ID" value="XP_038054530.1"/>
        <property type="gene ID" value="LOC119726760"/>
    </dbReference>
    <dbReference type="GeneID" id="119726760"/>
    <dbReference type="OMA" id="NRQCTST"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038123092" evidence="4">
        <location>
            <begin position="22"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="460" mass="50515" checksum="3098DC12A8E32846" modified="2023-02-22" version="1">MTRFVATVVACLIVCGKLADTAQDGYCFRYRDPLGSRGKCQQLVERLPGPDGAPVDTREACCLLGAEGWSNKISGKRCAAACEVPGPVEVQAPQVVQQVAEYEEDQNSVEGVWRRWSDWQPCSVTCGAGFEERRRVCRPSPDNPDDNFQCSGDRVEHRDCNAGIICPVHGQWGEWSLWSECSATCGDTMARFRECDSPSPQFEGNPCVGESREVQWCNDKRHCPIHGGWREWLDWSPCSVTCGRDGERRRIRKCTAPRPRYGGRDCVGDQTDIRSCKANALNCPVDGGVSEWGQWRCQGECTGEGFALRSRSCTNPVPRHGGRQCQERLNDIRDCSKVICPVDGMWSTWSPWNDCSSTCGKASFKTRTRQCDNPPPQNEGLKCQGEKFDNENCKLAPCLGDGDSSYSASADSSVEGGTTPPCDDEDYPSPTGEGGSGCRDPTDGSGNDVDNGEISSLEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVP6</accession>
    <name>A0A913ZVP6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055612.1">
        <property type="nucleotide sequence ID" value="XM_038199684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055613.1">
        <property type="nucleotide sequence ID" value="XM_038199685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199684.1">
        <property type="protein sequence ID" value="XP_038055612.1"/>
        <property type="gene ID" value="LOC119727684"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199685.1">
        <property type="protein sequence ID" value="XP_038055613.1"/>
        <property type="gene ID" value="LOC119727684"/>
    </dbReference>
    <dbReference type="GeneID" id="119727684"/>
    <dbReference type="OMA" id="DFHHFAF"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="196"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="360" mass="41474" checksum="1E7E5A11686CCC73" modified="2023-02-22" version="1">MAQMELEIRDKDNPENQDKGCPKNVVIQQQEKKQCSHDYQWTETLSILLFVIGGIILSLATIWNSLTWHLHWFWGASGNFWDEQWFKLHTLFGGNTFMLGVVCTQVITFVMYLVVNCVFVYVDVTGGPAFIVKYKIQQDQNVPVDWERLKKDFRSVLFNITVVNFVFLVCMYPMGLWCGVNADPNLPSFHRVLAEFVVYLIFEEIGFYYFHRLLHHPRLYKHFHKQHHEWTAPIGILTLYAHPVEHVLANLLPTVIGPFLMASHVAVVWVWLVIAQTSAVISHCGYHLPLLPSPEAHDFHHLKFVNCFGALGVLDRLHGTDAIFRQAKQYSRHCVLLGTTPLSQTYPDGTKGQKVIKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWC7</accession>
    <name>A0A913ZWC7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055958.1">
        <property type="nucleotide sequence ID" value="XM_038200030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200030.1">
        <property type="protein sequence ID" value="XP_038055958.1"/>
        <property type="gene ID" value="LOC119727674"/>
    </dbReference>
    <dbReference type="GeneID" id="119727674"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="712" mass="82358" checksum="1A905ADCC7B547DC" modified="2023-02-22" version="1">MNTSREHEKESFHPHRIVIIGSGPTALGAAKRLYDLGQGKNNSVITILEELGKPGGLASSVRDDKGFLWDVGVHVVFSHYTYFDRVLNMAVPEWNYRRRASFAFMKGSDDTRRFIPYPVQNNIHVMDKIYQQKSLKGLEEITKNPSTRKPKNFDEWLLQKFGEGLANVFMRKYNRKIWTVDTKEMNSAWVGERVAVPDIKEIKTKIAEVDNGTDAKDSEWGPNRFFRFPKYNGTGGIWESVARMLPSHWFRFYEKVTAIDIDRKIITVETGTGVKASHYSLAYDTLISTAPLDVFTSLLRSHDVSLWQMQELASQLVYTHTHIVGVGLTGQLPRILADKSWVYFPDSDSPFYRVTMFSNYSDDHVPNPGAYWSLMCEIAEPQKSSNPAYWSKENLIKESIQALVLYGFITADMVVSKHYRRLDHGYPVPSLKRDTILDTIQPWLKTKDIYSRGRFGGWKYEVANQDHSFMQGVEAVDKFLSNVPELTYPDPNRANSKKNTDRTIPLDYEFAIAHYNENLDWIKPHANHTLIYHQGNDLGPPFQFYGWERLENLGREAHAYLVHITTYYDQLANVTVFAQGDNMQGRCYKNIMQFIDSAKKGVPCILYPKVYKLWGNIPFSRRYLARFKTHKLDIANGTLGQMYQDLYGQPPPKAMWVCFNGCFAATKQQILRHPLEFYQKALAYVSKSPNQEESNYLERLWYHFFEEVNKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWC8</accession>
    <name>A0A913ZWC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055369.1">
        <property type="nucleotide sequence ID" value="XM_038199441.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055371.1">
        <property type="nucleotide sequence ID" value="XM_038199443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199441.1">
        <property type="protein sequence ID" value="XP_038055369.1"/>
        <property type="gene ID" value="LOC119727535"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199443.1">
        <property type="protein sequence ID" value="XP_038055371.1"/>
        <property type="gene ID" value="LOC119727535"/>
    </dbReference>
    <dbReference type="GeneID" id="119727535"/>
    <dbReference type="OMA" id="WRVEYGV"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="73"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="231" mass="26670" checksum="B6DF6D16A7A3E0C3" modified="2023-02-22" version="1">MGNPIEYDPNELVKLKERCEIIFNADPSQYLTEPSIIRFLKAFKNVDDSFAAILKCNQWRKDYGVETISPTSCPEVNAELNTGKVELLRHRDRHGRPMIMLRVRHHKVAERNKEVLTKCMVYILESACKKCNEDVIDNVCVLFDMRKFSLASMDYEFVKTLIWLLSTRYPERLGVCLIINAPMVFQGCWAIIRPMLSDITAQKVVFINDDMALANYLCPDALPENPFEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWQ7</accession>
    <name>A0A913ZWQ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055962.1">
        <property type="nucleotide sequence ID" value="XM_038200034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200034.1">
        <property type="protein sequence ID" value="XP_038055962.1"/>
        <property type="gene ID" value="LOC119727952"/>
    </dbReference>
    <dbReference type="GeneID" id="119727952"/>
    <dbReference type="OMA" id="AYKNTHI"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="47"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="46323" checksum="1179AB465DC0A5BF" modified="2023-02-22" version="1">MGDSKHEGTGPPTPLQNNSGSAELEWTPQTILAMVSVSLLTILTIFGNVLVIIAVVKYKRLQIPSNYILVNLAVADVSVAVFAPLVFVVELLGYLVTNVYLCILPYCLVTLGCGVSLLSLGIVAYDRYAALVKPLKYYQHVTMRRVLCFSLVIWMFVFIIAFMPLCWQFLVESQTDDQPACSFYLLSKYLLLFQVLVIFVPAFLVMIGCYCRVMLVARHHSRAISAIQLSLFPNTFSKNLHMFKGTKYTRTLLIILGFFFLTWVTFTLMLLIERFCDICSRTIPLHHYSVFLIFANSALNPWIYAHRNQDFKSAFRRLFRCGKKSQRSSARGPEGRRNSRVSDALSRTNSMVGGLQHLHVLYNNADIVPPAVDAETGQLDSKTSFRAAPKLIQHNISKPVVETVAEEVSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWX4</accession>
    <name>A0A913ZWX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055790.1">
        <property type="nucleotide sequence ID" value="XM_038199862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199862.1">
        <property type="protein sequence ID" value="XP_038055790.1"/>
        <property type="gene ID" value="LOC119727797"/>
    </dbReference>
    <dbReference type="GeneID" id="119727797"/>
    <dbReference type="OrthoDB" id="3268608at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="311" mass="33374" checksum="E5A03DAE353D0CD6" modified="2023-02-22" version="1">MDPAPIHCPHCDQTFGRRRNLKRHLNTACVALHPERPYPCQRGCGVRFFRADVRARHHRFCQGDSVAVVMAEADVLEVHASDDDMRQAPSPPHLSRQGTPDPPPFGRCGPAGRSPSPPPLRRRVSPESSGGRGAATTRSGPPGLPALNRTGHLVGGAGTGPSDPASHHPGGVPTGGSPGAVPRAGVLASAGQRKQALVTPSRHGRRAERRRNPRCPLRFGRDLAATGDGRRPPPGQHHQGGRHAHAGTPTYQGQQYGQHFVDPSVSAQPSLGGMLPPGAPPPPRYPDGVPREFWEQLFRHTEFQRRPPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXD2</accession>
    <name>A0A913ZXD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038055955.1">
        <property type="nucleotide sequence ID" value="XM_038200027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200027.1">
        <property type="protein sequence ID" value="XP_038055955.1"/>
        <property type="gene ID" value="LOC119727947"/>
    </dbReference>
    <dbReference type="GeneID" id="119727947"/>
    <dbReference type="OMA" id="ANNISCL"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="122"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="365"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="508"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="629" mass="68288" checksum="9A32910E4EC99870" modified="2023-02-22" version="1">MVSDSPLPETVEYGKSRYGKNQGFFESRNTELLRLYRSLSPWISRHRSHVLGANLSEESTMMASLGKVLQELHGTGSVRPEPAEEIDDTVGAFQSDMLLTPKQMQEVMELIEEGKTGVEKRKAVAYLNYRWPQNTVPYEFDSSSEADRDAIMAGMSLWSEESCVQFVPYSAQVASSLGHENRIQFYKGSGCSSYVGMIGAGAQQVSIGNGCTGAGTIAHEIGHALGWHHEQSRPDRDEAVTVNYDNVQPGREINFAKYSTAQISTHDVPYDISSIMHYGSGYFSANGEPTIVALDPVDQFLMGNRADFSFYDMKLANIMFGCSDHCNTNLQCQNEGYIGKDCTCVCKPGYSGTHCESFNPDSLGCIRKMTALTGTLESSGYPAQYQNNAVCAWQIMGGAGSTISLSFEAFSLETDATCRYDKLTVRAGTDISTGGQVFCGTTIPPEIESVGNQMLVIFSSDNIITAPGFQANYVIHGNTVATNAPPPPFPAITTNQPAVATTRAPTNCEVIPGTCGGTYGNAGCIASPNYGEGTYNSDEECIYNIEVPSDQRVELNLMDLDIEEQSSCAWDRLEIDLGSDFIGTLKLCGSNRPTGSIVSMTNKMQIRLISDSYVNKKGFAAAYKAVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXY8</accession>
    <name>A0A913ZXY8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056185.1">
        <property type="nucleotide sequence ID" value="XM_038200257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200257.1">
        <property type="protein sequence ID" value="XP_038056185.1"/>
        <property type="gene ID" value="LOC119728171"/>
    </dbReference>
    <dbReference type="GeneID" id="119728171"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="839" mass="92727" checksum="58F87E28EFAA114B" modified="2023-02-22" version="1">MNALHRAILAGRPTEVLYLLERRKHDPNARDQNLRTPLITCSLTDKEDEAVTCAAILLSKGAKISHSDRRGKDAFCWACQNSRAKLVKMFLEDYPNQFQFDLRKRDRDGNTALHLASRTDNPDIVGLLLRAYAANNLFAEMTERNSRGETPLQVAAKRGNSSAVLTLLPVSSDALFTRRGGVDFRSAPKWANAAVKVSRSTGDWRVKHGRPYSEQLSVGSSANINAPGPTTGKRRPKTVSVTADSSNLIGHSGSVIRSKPGWNLSVLPRRTNISDIFRISEVQLSASSAYRRPAKAPPPPTPFVGEDDKNNRQRSSTLKLPCKGRRGSVLTNRSRSSSSRRASVSDADLADKTPNKGGRAVPTLVIDKPLEQVKSVPAVILDTDGNEARGSRRLLTLEGKEDVNLGRQAKRSSSFNHSMSDIPESPVQGGTYLAPFNGPGMTHDFIGSANSLHSLASDLPGLFAHALAFDRSETDPTIKHDGSHASLIRRTKSEPSLNTLDQAIESLLVSGKSNGPRPDQKRSSRSKGPISNRRRGHAKMRTADKDKHESTVSGKRQTKLTPLKVETPNHGVPHVHQLGHLPTPSVSQSPAQSSRSGRRFFRSSREAESAMRRRRTDLEKRIKSVQEDIERLDSRRRGRKYRSLIPDWVTLDEETTLEELVSAILNDKTNRETTGKSVRKQHRPQDAMSGETNSATTNYPRDMRAYNSASTESSRDFDPEQEPTHSCSSSLDLDAEIQDVGRPQRPRLLKNSLRGEPLRVPRPAQAPVYKQSRTIFSSHPPIHVLPRQQHAAYHLTAENSPDPSIQARVGKLANQVSGHRYRAIKPGQASTKKNHKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZB9</accession>
    <name>A0A913ZZB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056667.1">
        <property type="nucleotide sequence ID" value="XM_038200739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056669.1">
        <property type="nucleotide sequence ID" value="XM_038200741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056670.1">
        <property type="nucleotide sequence ID" value="XM_038200742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200739.1">
        <property type="protein sequence ID" value="XP_038056667.1"/>
        <property type="gene ID" value="LOC119728483"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200741.1">
        <property type="protein sequence ID" value="XP_038056669.1"/>
        <property type="gene ID" value="LOC119728483"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200742.1">
        <property type="protein sequence ID" value="XP_038056670.1"/>
        <property type="gene ID" value="LOC119728483"/>
    </dbReference>
    <dbReference type="GeneID" id="119728483"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="453" mass="48886" checksum="6B75AA53B4CA5303" modified="2023-02-22" version="1">MSSPENGPVNNYDHDKYGWVMVAVTFLNWAVIMGNTKALGVLLIPITHDLDSELWLIGWLVVLYGLMLNCLGPIVGALCRLLGVRPMMVFGAVLLTLGIILTAISPNVFAMAIFIVGLAGVGSALILFVSFAVMASYFKKKYALAVGLSTMGIPVGVMAYGPVTQMLLDTYGWRGTMLLLGGFSFHLVACSMLVRRNASSSAATEQYQEVTQSDEEENSPSEDGRVRGTNRTNISSETRQTVSGGWARVCCQSIHKAFDFAVLTDMQFILVVSSRCAPAFAYSGVVVYMVSHGQLQGLSEMQASFLPTSFGSGNIIGKLVMPLLQQMGIKVSMTFWACFASCVVCVSLLLDAFVTPFMGQMVVTGLLGVGYGISIQAMDVIVRFIFTDDRLVNVLGWQGLCTGIAAGLGGLVAGWINEWTGSFNIAFYLYGGVTLLSIPLVLFQDLYAKRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0R8</accession>
    <name>A0A914A0R8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">R-spondin Fu-CRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057190.1">
        <property type="nucleotide sequence ID" value="XM_038201262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0R8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201262.1">
        <property type="protein sequence ID" value="XP_038057190.1"/>
        <property type="gene ID" value="LOC119728854"/>
    </dbReference>
    <dbReference type="GeneID" id="119728854"/>
    <dbReference type="OMA" id="KCGSECE"/>
    <dbReference type="OrthoDB" id="10257656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF7">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872791" description="R-spondin Fu-CRD domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="12">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="13">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39222" checksum="EB91241B9F7AB70B" modified="2023-02-22" version="1">MVLIDLEMVLVLCLSVLLAVVDTGETWRVKTRACPQGCNSCSLFNGCITCKPRYLLLLHRSGMKQVGYCRRTCPLGYYASRGGDINRCSKCQVENCEDCFARNFCVRCQSPYYAHEGKCFTVCPEGTWGDRKSGDCLETVHCEVSEWGSWSTCRKNGADCGYKWGEETRMRGIMTQATPGGKACPELTETRKCRILQRNCPVDCGVSEWSSWSPCSKDSADCGYKWGEETRVRHVSTPPSNDGKMCPDLTETRECRMLQRHCSDDEADTETGKKKGRKNRRNNRRRKNRRRDRPRKSRTHSSTQTQGEGEDVITTERTRLRSRTEDPGVQSREISRDLPTDLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A119</accession>
    <name>A0A914A119_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057046.1">
        <property type="nucleotide sequence ID" value="XM_038201118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A119"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201118.1">
        <property type="protein sequence ID" value="XP_038057046.1"/>
        <property type="gene ID" value="LOC119728748"/>
    </dbReference>
    <dbReference type="GeneID" id="119728748"/>
    <dbReference type="OMA" id="IHFVSFA"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="67751" checksum="264E860D556F2A56" modified="2023-02-22" version="1">MDARCGCSWQVAGEAVNDADAKMAVPPRRLARCLRPGPLAVIASFFIFFLSLGNVSSFVILYVYLQKDFHASAIETGWVGSAAWAVMNFLAPLPSVLYVRFGCQRVILVGFLLSFAGLLASSFANHLWILYITYGLAFGAGSNFILTATINLVTSHYPGDNNIRATSLASAGQPVGLLVISGFLERACYYLGWRNGLRIMSGLTLAIGMVCTALSRQPSPIIAEDEDVDCKPVSAERGAGCSNADPLANGSAARPVQITGLARGLRSKKAYQPIPSQEGDVADNSDQAVHECAIHHSKSFSELDQRESNPHSGSKIEMGLRLTSSSDNLRMNSSVANHRLTETGNPIEDVGAETSFTDAHGARSATTVSDTESDLTELETMPANGNNATTRLKRAESSFWVRYVRLLRLPGHWLFFSGVIASSLGALFNVIHFVSFAETVGIPEPTASVLLLVMSGMEIASRVLVCICGNQAPIGRIIILAVVCVMAAVATYALVVLPTFAVVTIYVIILGFARGMIYAIALGATIDTFGVDRALESYTSLLLSYGIAGALASTIGISKDLTGSFTISLHIIAVLFLVAAILFVSAHVWRKRNPLNGQRKLIESDVNANICDDGGKGVEHQGNGVLPTEQVSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3J5</accession>
    <name>A0A914A3J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058417.1">
        <property type="nucleotide sequence ID" value="XM_038202489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202489.1">
        <property type="protein sequence ID" value="XP_038058417.1"/>
        <property type="gene ID" value="LOC119729733"/>
    </dbReference>
    <dbReference type="GeneID" id="119729733"/>
    <dbReference type="OMA" id="EGSCTCC"/>
    <dbReference type="OrthoDB" id="10021193at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036769378" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="141"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="424"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="711"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="845" mass="86525" checksum="5F88C7E6AD0C8322" modified="2023-02-22" version="1">MASRINCKYFAIVGVFLVGAYGSFVPTNVPEGSSPEWSCTCCQGQAGHPGIPGVPGVNGPPGPIGPKGDPGFGLPGPKGGFGDQGQKGDQGKSGIRGAPGKLGPAGPKGDQGLTGVRGQSGSPGLRGSTGRKGEQGETGSTSASVVAFSASLGSTFIGTTGRDTIVFGVVEANVGAGYNAQTGVFTCSIPGVYYFTVSLMSLSYSTRPRVKLQKNGNSSLLGVYDNHPGYHHQPSNSVVTVLAAGDTVWLETSSASASIDGVVVVTVLVKQKRPSGLISVMLLLWLSNCHCIAQEEPKGLSGCCSACFQGQAGTPGVPGIPGNPGGIGVQGPLGPKGDPGFGLTGPKGETGDQGQKGETGDQGQNGDQGEPGLQGTPGKQGPAGPKGGIGKGQKGDQGEHGVQGLPGEQGIKGQPGDATIVTPTPPSAVAFSAYRTARVTGDAGDVIIFDNIETNLGDGYDSGTGVFTCSITGAYFFTTSVHRIYSSTHPHLILRKNDEKIFAIYDSDSNSYQQSSNSAILSLTSGDRVWLEFGSSGRGIYSESGNKYSYFSGFLIYANMEISDPFRTSDRRRTPTGDVADLCRRRIDVCLLSGKGSSCCGACFQGPAGTPGVPGIPGNPGGFGVQGPLGPKGDPGFGLTGPKGETGDQGRKGDRGDPGTRGPLGKQGPAGRKGDIGEGQKGDQGEQGVQGLPGERGQKGQPGDATLVTKTPPSAVAFSVYRTSSISSSSSGDNIIFDNIETNLGDGYDSQSGVFTCSVSGAYFFTASFLRYSSTPYVKLKKNSQLVFSIYDGQSNVHHQSSNSAIVVLATGDRVWLEFAGSNSGIHCESSNRYCCFSGFLISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A709</accession>
    <name>A0A914A709_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038059652.1">
        <property type="nucleotide sequence ID" value="XM_038203724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A709"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203724.1">
        <property type="protein sequence ID" value="XP_038059652.1"/>
        <property type="gene ID" value="LOC119730716"/>
    </dbReference>
    <dbReference type="GeneID" id="119730716"/>
    <dbReference type="CTD" id="548593"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000008">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="13">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="294" mass="33834" checksum="19A2C54B59305780" modified="2023-02-22" version="1">MVVEIEKFFGCYLLLNLNPDFKGRTYIGFTVDPRRRINQHNKGSKYGGAKRTSGKGPWEMVLIVYGFPNKVSALMFEWAWQHPRLCKRLKHVPGKRKTEKRFLFDLRVLSNMLKVGPWCRLPLTIQWLKQEHMREFEDGLQPPVHMPIAFGPVTSIKMHSKTKKKLSKKSNKNAESNLEETEEDRCSEDMVEMTQRANKRCDVCSKRLQPDSTSTLSCVHPTCSMKAHMLCLAGQFLRHSAGDFLLPVDGSCPLCKKNVLWGDLIRKKEGCYSTLAVCDDDDTDDHWAEELRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A766</accession>
    <name>A0A914A766_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxalase domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059615.1">
        <property type="nucleotide sequence ID" value="XM_038203687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A766"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203687.1">
        <property type="protein sequence ID" value="XP_038059615.1"/>
        <property type="gene ID" value="LOC119730692"/>
    </dbReference>
    <dbReference type="GeneID" id="119730692"/>
    <dbReference type="CTD" id="392465"/>
    <dbReference type="OMA" id="FGTHKIN"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="135" mass="14848" checksum="522D414FC7ACDF28" modified="2023-02-22" version="1">MASASRIVIKRLDHLVLTVQNIGATVSFYNKVLGMELVSFKGDRKALRFGQQKINLHEAGKEFEPKAQHPTPGSADICLISETSSEDVVRHLEVCGVPVVEGPVTRTGALGPIRSVYFRDPDRNLIEVSNYEDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A902</accession>
    <name>A0A914A902_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059916.1">
        <property type="nucleotide sequence ID" value="XM_038203988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A902"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203988.1">
        <property type="protein sequence ID" value="XP_038059916.1"/>
        <property type="gene ID" value="LOC119730922"/>
    </dbReference>
    <dbReference type="GeneID" id="119730922"/>
    <dbReference type="OMA" id="IVHVFAG"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="498" mass="53649" checksum="3CAA4D57D61BF981" modified="2023-02-22" version="1">MTADAMNEKKGSGEPRNRGSLESSNTCDENENMDSTVKLKREIGLVRAVSLIIGAMIGSGIFISPKGVLLATNSVGMSLVVWFICAVVSSLGAMCFAELGAVVPLAGGPYQYALHAYGNLPGFMVAWSLVVIMMPAGVAMTAITLGTYTSDYVIPGDCAPPREAIQLFAILSVMLIVFINCVSVRVASGLSVVFSGAKVIALMVIIIAGLVKVFQGHTEYLDPSVSFEGSTTQFLGYGLAFYNGLWAYAGWEILNSVTEELKNPGRNIPLAIGIAIPAVTIIYLLTNIAYFTTLSPTELLASSAVAVTFAERTLGPMAWVIPVGVCISTFGNLLGNILASPRIAFAAGREGHMLKVLSMINVKRLTPLPAIVLQAIIAIILILLGDFNSILKFASFVSYIFHGAAFMAVLILRRKYPDKPRPFRVNVLIPIFATAVCVFMILAPLIAAPTLEYLYALVLLAIGLVVYLVFVWGKRQLPFMNQMTLFYQKLFLVSPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9S0</accession>
    <name>A0A914A9S0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060513.1">
        <property type="nucleotide sequence ID" value="XM_038204585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9S0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204585.1">
        <property type="protein sequence ID" value="XP_038060513.1"/>
        <property type="gene ID" value="LOC119731414"/>
    </dbReference>
    <dbReference type="GeneID" id="119731414"/>
    <dbReference type="OMA" id="FIWMESI"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="40636" checksum="205699684350FC9D" modified="2023-02-22" version="1">MAFSTNSTPELNSTFEVLYTYPELVFLAVGFSILIVLAISGNCLVLVAVARTKKLQNITNVFVVNLSVTDFLSSFAILWTVPGLLSKTPGYPLQPDIMCVASASLVYITISTSLFTLANIALNRCILVIRPMETYQWLYTPKKTALMVFGSWLIPVCTTIIPPLSGIGGLGFDPETRSCKDVETHPRADEYDNLQFAVFCPLPFLVIITSYLLIWRHVRRHFKKRGQHEHGLQSSSGRRSGPSSSSKQESDDAHTSSSQQSARAIKSTLSSRRLSRRMRNEQLAITKNLFLIVLVFMVCVIPHAIIDVTSNHRYELYGALILFISCCINPLIYAVKHPHFGPVMRALIRSRYTSESKSSSQKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA07</accession>
    <name>A0A914AA07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060598.1">
        <property type="nucleotide sequence ID" value="XM_038204670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204670.1">
        <property type="protein sequence ID" value="XP_038060598.1"/>
        <property type="gene ID" value="LOC119731483"/>
    </dbReference>
    <dbReference type="GeneID" id="119731483"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433633" description="F5/8 type C domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23307" checksum="717389908D33CCC1" modified="2023-02-22" version="1">MDGAAALVLMLSAMAVLLVGVESQQRVCYSGPPPEPDPDNPDDWMKQVMREIRKRCPGRRQPTPAECLQPLGMADGTIQDNRITASSSRHCCPASDGRLYSNNKWLTSISNDPWIEVDLVQSTVVTGVTTQGSGSSSYVMRYKVAYRQQPSSQRKHVTDGNGDIKVFIGNTDIDTPVTNLFDECVVATVVRIEPTESHGGAALRLELLGCRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABG1</accession>
    <name>A0A914ABG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061083.1">
        <property type="nucleotide sequence ID" value="XM_038205155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205155.1">
        <property type="protein sequence ID" value="XP_038061083.1"/>
        <property type="gene ID" value="LOC119731872"/>
    </dbReference>
    <dbReference type="GeneID" id="119731872"/>
    <dbReference type="OMA" id="NDCFHSH"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37514" checksum="F332053904DE4D9A" modified="2023-02-22" version="1">MSGAISSASGVETSSYTREHTFYAAENRALRGFAFAFKTVRSRVICGRECSMDERCKSFNFNDCNKMCELNLATRREHPEDFNATQGSVYFDADENTPLYSLTDSSLNRYRSCKMLLDAGYRSSGIYTIYPEGFGHCSLCVFCDMETDGGGWIVFQRRQDGSVDFYRNWAEYQSGFGNLSGEFWLGNDNLVTLTSDDSRGTWELRVDLEDWENNTAWAKYADFQISSGEYNLKYDRKVGGTAGDSLRWHKSRPFSTNDRDNDAVSYNCAWSWKGAWWFNDCFHSHLNGPYFPFAHVEYARGVQWKAWKGYYYSLKSCSMKMRELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABG8</accession>
    <name>A0A914ABG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FIST C-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060699.1">
        <property type="nucleotide sequence ID" value="XM_038204771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204771.1">
        <property type="protein sequence ID" value="XP_038060699.1"/>
        <property type="gene ID" value="LOC119731577"/>
    </dbReference>
    <dbReference type="GeneID" id="119731577"/>
    <dbReference type="OrthoDB" id="509497at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14939:SF5">
        <property type="entry name" value="F-BOX ONLY PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST C-domain" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19070" checksum="049482ED2A886DAF" modified="2023-02-22" version="1">MARDNHVAVLPEMNVQGPGYFLIENMNTGTNSKKLPSCLTVRFSGPNVRAAFVVLGNSVTTRDKARSKFQELKKLGLPAKHSLAFLFSCVGRGRHFYQAEDVESGAFHEVFPDTPLVGFFGGGEYGCDNFTLGRSVQESADRDSADLRRRNALKKLQNLEKSFTCVVCLLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABP7</accession>
    <name>A0A914ABP7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061163.1">
        <property type="nucleotide sequence ID" value="XM_038205235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205235.1">
        <property type="protein sequence ID" value="XP_038061163.1"/>
        <property type="gene ID" value="LOC119731934"/>
    </dbReference>
    <dbReference type="GeneID" id="119731934"/>
    <dbReference type="OMA" id="HFIPDMT"/>
    <dbReference type="OrthoDB" id="10039245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="109" mass="12292" checksum="EBD35093F1B37FDE" modified="2023-02-22" version="1">MLLQDMEIPGFTAHIELAETVPHFIPDMTSRLLDCASGTGLLGQELKKRGFLRIDALDTSKESLDYSRKKQVYTNYFYTYDGICMCAAMGKAHVRPDCFPELVRITKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC50</accession>
    <name>A0A914AC50_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061495.1">
        <property type="nucleotide sequence ID" value="XM_038205567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC50"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205567.1">
        <property type="protein sequence ID" value="XP_038061495.1"/>
        <property type="gene ID" value="LOC119732158"/>
    </dbReference>
    <dbReference type="GeneID" id="119732158"/>
    <dbReference type="OrthoDB" id="10464397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036974371" evidence="2">
        <location>
            <begin position="28"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="615" mass="65850" checksum="21AF895D8C7F2E49" modified="2023-02-22" version="1">MAFIIASKCGCVPVLVFFTCWLWIAHAHNANGVLSSDYSDSMHSSSSDDYDGIIVEPSDVYDVIMTSSDLSSTSSDTSSSVDEPTDPVDTSYVPSDSAGESSAASSLLSADVIICPSATIDELSSDVSSSSASSSLSSGIDLSDNEEPSVDNEDPPYVPPTDYESSRTSSSDVYPQSLEKKTAKSGSEAAGKPKRGPASLDDSSPDSNGKGKPGRPPAVFNGPRREDGTTRREGHGKRIVPAGVEDGTDAAGRKPARGGKPAQENGKGPSSKRPGRQWGGPPSIQRRKELREADTKYLDMYLCGQFFTETAADFAVVSFNYAGRTQPFSPCSELGSTSDTINYIYRAASGDRSALQQVLDDLPATWERYIAEKGAAPRIVHVFTVNMPASRADVSSLIGLRHSDMTGPARFVLGYLNQPTSSETHSAREFLDMLGELTDARIDPLRVCGRCAKVAGYPAGGRRRRDMLFGMSVVSGASTEVQCLPLQEHSIPGADLTTNTCDGFQKSIVRCTLRSIERRCRGTGSGTDSPRIDSDDETDLIDSTVIRLTQECAVDSDCWRRVGESIRLPAAPKSQNRCNMPEIALSKILGRCAAAAASLPFNVDTELLDRQSRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG36</accession>
    <name>A0A914AG36_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062687.1">
        <property type="nucleotide sequence ID" value="XM_038206759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206759.1">
        <property type="protein sequence ID" value="XP_038062687.1"/>
        <property type="gene ID" value="LOC119733180"/>
    </dbReference>
    <dbReference type="GeneID" id="119733180"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="401"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="617"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="872"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1754" mass="195854" checksum="39D66553DEF50182" modified="2023-02-22" version="1">MAEPPGEGAQRRNETQTNPGPSTAPASQAAATQQLPAGNKQPSQQEPTQQPPPQLQPRPGETQTNPGPSTAATQQLPADGVRDDQQTIQSGSGHPSQQEPTPQPPPQLQPRPGETQTNPGPSTAATQQLPADGVRDDQQTTQSGSGHPSQQEPTPRPPPQLQPRPGETQTNPGPSTAPASQAAATQQLPAGKKQPSQQEPTQQPQPQLQPRPVELEVEFTPTTYPHITELVLRKISERLGAEWRKLATYLGLSAAEIDRIVLDDSAGQTESQIFNMLVSWSRQQSTSTDQREVLYTALIEIGRRDIAEDLLGINDTILRVISEKLSSECKWQNLATHLGLSAAEIEHIVMDCPHQTQNQIFNMLVKWRRQQTASADQRKVLRRALIEIDRKDIAEDLLGITDTILRKISEKLSSEWQKLATHLGLSAAEIKHIVMDDPGQTENQIFNMLVKWRRQQTTSADQRKVLRTALMEISKGDIAEDLLDCPKVSIETSVARRGFNDSDLSNRLWTRIKLILDSVHQLVSAYLNPCDGELVELRRGSVTFVVRFKSREGLNKLRSLYDTGELAKKLTEILITDELTTEDKSDLAIQATIPESDYDQACRFFDELEKDQQKGISDPVLHKISERLCSEWRKLATHLGLSAAEIKHIVMDDPGQTENQIYNMLAEWRGQQSTSTDQRDVLCTALMEIGRRDIVENLLDYVMRAQEADANEHAEKRKAEATVLKDQGNQAFKKSDYTRAVELYTQGLERLKDFVVLYTNRAQAHNKLGKFSEAMEDCRTALQLEPNNVKALVHLGKAQQGLKDYEAAVTTYQEILKIDEKYEKMVAGYIAAVNLAESTAKSDMEAERLFNEGNVKASGVHEIGLSEVGDSPAALTQQSDPDDQQNSQSSNERPSHQEPTPQPPPQLQPRPGETQTNPGPSTAPTQQLPADGVRDDQRTTQSGSRQPSQQEPTQQPPQPRPDYPQQSGASIGSIGTISGSQNPVIVGSNVNITYNLPLQGPETTGHQGPGTFEDLQQEIIDNYKRTTTTIPAHPVVQSRKVDIDKFFIPLFLRKNIQGKRESKRSVRLPEGKRLLDINQTTRLNSLDDLLNPEVVKEIKILLCGGAGTGKSTLLVKVANSCITLSSKPLLGRFDLVLWIKLRQMQQSSCVLDAIFDQILARNTKLTKHIVKGFIDDHESGIALLLDGVDEIPSHVLESEEGVYRVQDILQSRVLSKSFVLVTTRPHLTEYVLSCDHQYAVVETIGFTPQDRDQYIRLNLPDDADMGDKLISNLKDNANLQEMAVVPIISQMLCIVWENQQSLPERITELYADFALALFKRRNKDMSDEQVMSNMMSIIDSLGRVALQGLLDFRGERLMFDKTEFQDCQSCLDDGCLVGFVQLENYTSGLHVNVLVTFPHKSIQEYFAACHLVKLLQDDENNFRHQLKQIGEGNVLAMEYLLRFCCGRSMQAAGFILDHIQEMQGDEEELQGLARLLMFEAGSEELATKLVRPTRVACKSNEDLKSLSYYLQHVTPPLQGAGFHMCVRKQELTILRGILLSDSMKSAGLIAVRYYLSEQEEEELILLEETLGVVDEQHPAELHVVVCIEAKSWFDVGRVSHRFFHMQEQIGDLGLVMFQRSPDEVVDLLKALEGCRLDWLTLYGTNLHARVRHVSHILSSLKFLQLNACRLVDDDVKDLISILPAGHGVEGLTLDDNAFSLDAVRALTHHLQGLPGLSYLRLRNIGLDAELVRQVVSQDLPHLKETEEGEFEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGF0</accession>
    <name>A0A914AGF0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062792.1">
        <property type="nucleotide sequence ID" value="XM_038206864.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206864.1">
        <property type="protein sequence ID" value="XP_038062792.1"/>
        <property type="gene ID" value="LOC119733277"/>
    </dbReference>
    <dbReference type="GeneID" id="119733277"/>
    <dbReference type="OMA" id="CIDACED"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20832">
        <property type="entry name" value="C1_ARHGEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="17">
        <location>
            <begin position="449"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="15">
        <location>
            <begin position="662"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="14">
        <location>
            <begin position="969"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1200"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="717"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="808"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1496"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1748"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="907"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1556"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1748"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1841"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1856"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1919"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1931"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1970"/>
            <end position="1991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1991" mass="221514" checksum="BF4ABD5FCFD31DA1" modified="2023-02-22" version="1">METFQDQYGPQLIQRCVIVQKDERGYGLTVSGDNPVFIQSVKDDGAAFRAGVQKGDRIIKVNGTLVTSCNHLEVVKLIRSASYAALTLLGLPPGMKNQSPLSPPHQGNATAKPNQRREVTRPVAVTPEKDAELKNERMQTLKEMLEQEKELYQRMKSVYDVNPTEKLFRELSGITTRIKVMESQLTRAASMQAKVQTTDPREVQSSADQEVENKNRNAQQNNHKEKRKSETRSWLPHGIIHARQRSSPETLGVMSEIQPGTNLKRNNSDAQSKETAARKKHVRGMGAAESEIRRKRSDNIEQLGRSQSLPAEPGGADSDMADSSPNSTPPAKRRTDTDSSLENQEGGSVVSMTTKPHRDGTVVPPSQPFKIATVGTVEPLTSEVLTNMQAPQVQIMSMEDDDFQSDNETHKRDSACSVSQPKFETLQESMSDHPHGNIQSFEDHGPFIKLEQLEKKPAHMSIFLHYLISNSDPSSLFFYLVTDNYRTGSLKEMKKWVYEIFSTFLAPLAPLRIQVNDGIVQSIETTMSTQLQNEEAMKSIFLAARQSATAEIRELLADFRAKRALGLGSIFGDQQLHNEDMDRTQELKIVEQTLMPHLDRLTTLEAEREDKNVAMAFAITTFMKQVGVRVTSNSPLERCPSFTARDKRTKWGGKNKKQHIKGHQFVEMHYQSTVFCNHCNGLLWGIGFQGYQCQNCEFNVHKTGLCLDQLEDPCQGKEGKKSKNWRRMIPGGQRRTSDRMSQYLPPVFFAGDRKDDSEKTATSPSAAISPLPIPPIRPGLGEDEEITQLKKEVNVDSLVKQFEVKTDDPLVGSHSSQTDSGISESYDRLQDVTEGETTATKRSFLNRSASLKTKGEEKRERRPPGDRRSRSVLVSSSNDRTSSQSTDDVDMDGHSVVTALTNTAHDSSSSSLSTRSQDSQSASNDSLSCRPNEEDQAEDSDMEAEAEPSNWQDFVDKDIVKRLKPKEVKRQEVINELFHTERSHVRNLKVLDRVFYRPMLREQVLSKELIHAIFPNLNEMLELHGPLNEYMKKERKTSHVIQQVGHVLLKTFDGEAGETAKRICATFCQNQKAALEMLKHRQKKDSRLAQFLTDAEANSLCRRLPLQAIISTGMQRLTKYPLLIENLLKYTPAKSKEYEVLGKCSQCTKKLLAHVNQAVKECENHQRLVDINRHLDKGPFERSNHPIAAEYKSLDLTSRKLLHDGALTWKLSKTKTLDIYALLFSDILVVLQKQDDRYVMKCHSTTVPTQLEEKKNTHSPIIKINSVLCREVATNKRAFFLVSTSNAGPQIYELTTISTSERQAWMDMILRTQEMIRKNGKTGEPGAASSTVSNSYFKIIEEDSEDIAGKPDSGEGAAKHMEAGPSSIEINHPPQVSQPEVVIQGSMVTDEPRQESPLEASSTMAKLLQEDMSSDARATDKAYMISALSTHLSVLQKANYEKRDSKREELIDKATTQIQTLSKSLQGDFTRIESELQQKTQELTRAQQALLEQSQNQLEEQRQLEQRQQEQRQSGPESFYIRSPNALRTETSDEIAARKKANRISSSADSGGSTTDSEESGAVESSEPEEAYTPKERPSSLVMESEEGDQLMNVGAQYQRAEPQEAVAIVNEGLVNLQRAQVRKVTDVDSAEVDHIMERLHIKRASVNGIKDRTGPGENLRSVTDSEDMEEMTESAQELSIGNVALAEENWGTPPKELEALENQAVEVGMATRLDDLLNEDSDSDQETVVASGSFKTEQLEHDADLINTSPEITQSQDAFSSSESDPNAISTPSAEKSRNENGGTDSTSNQIPSTNQDCVIDSSQSETNFANLSQTSKAQSPKLPNEADTTTLPSLGEPSGVNSQPTSLIATTDSETEKTRQEEGHVSLQGDDAKNSGAEVGEQDVATAETNQVVDVSEAGGENEKHSDEDVEEISQEGGEKDEHVSGDGESGESDNDDEDDGNDSDEEDNGEDDDRGNEGESRGVGEIPEVDGGDYDDDDDDSGDYETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH73</accession>
    <name>A0A914AH73_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063043.1">
        <property type="nucleotide sequence ID" value="XM_038207115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207115.1">
        <property type="protein sequence ID" value="XP_038063043.1"/>
        <property type="gene ID" value="LOC119733737"/>
    </dbReference>
    <dbReference type="GeneID" id="119733737"/>
    <dbReference type="OrthoDB" id="16287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043516">
        <property type="term" value="P:regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="130" mass="14924" checksum="CC4C4757CD12AAD5" modified="2023-02-22" version="1">HFDAGEFLMEYDGKLISAAEGERREETTDSFFRYFFTSRGTCTLIFFFFDCIHCGIDATSEPTEGKQLGRLVNHGDLKEANSKMKVIMDGDKPTLCLFSIKPIQKAKEVLYDYGINKPEMVSQHLKMHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ77</accession>
    <name>A0A914AJ77_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063459.1">
        <property type="nucleotide sequence ID" value="XM_038207531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063460.1">
        <property type="nucleotide sequence ID" value="XM_038207532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ77"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207531.1">
        <property type="protein sequence ID" value="XP_038063459.1"/>
        <property type="gene ID" value="LOC119734181"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207532.1">
        <property type="protein sequence ID" value="XP_038063460.1"/>
        <property type="gene ID" value="LOC119734181"/>
    </dbReference>
    <dbReference type="GeneID" id="119734181"/>
    <dbReference type="CTD" id="6193"/>
    <dbReference type="OMA" id="QAEDAVW"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="48"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="206" mass="23249" checksum="95EC018D3ABAD510" modified="2023-02-22" version="1">MTENWDEVAVIAEAEVPEVHLFGRWSCDEVSVSDISLTDYIAVKEKYAKYLPHSAQRYQVKRFRKAQCPVVERLTSSMMMHGRNNGKKLLTMRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK52</accession>
    <name>A0A914AK52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063946.1">
        <property type="nucleotide sequence ID" value="XM_038208018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208018.1">
        <property type="protein sequence ID" value="XP_038063946.1"/>
        <property type="gene ID" value="LOC119734488"/>
    </dbReference>
    <dbReference type="GeneID" id="119734488"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000028">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000003">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="311"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="407"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="496" mass="56125" checksum="897207E1EDCCC2B9" modified="2023-02-22" version="1">MPGVDSNTASDVSLAHPHLTPEDEAHYAKLFGQLDVNKDGRIDVEDLQEGLERLGVHTVPGHAQKFMSKSDRNKDGHLDFAEFVQYVTEHEKQLKLVFKHIDHNQDGHLDVHEILESLRKLGVSVSEEEADRLMKRLKGCKGCEVPTHLEDDVECVCYMDKDGSLKVDWNEWRNYLLLHPSADLKDIYTYWKHATFIDIGETLSVPDEFTEDERQTGRWWRILLAGGAAGAVSRTVTAPLDRLKVIFQVIGSKKQNLSIISGFQHMYREGGLMSMWRGNGINVVKIAPETALKFVAYEHLKKLIKSEGRELRIHHRFMAGSLAGVFSQTMIYPMEVLKTRLAIRKTGQYKGILDCAVKVYKNEGLRCFYKGYIPNVLGIIPYAGIDLAVYETVKNRWLKNHRESSAPPTLVLLACGTFSSTCGQIASYPLALVRTRLQAQLTRDNSMVSLFRDIYRQEGVRGLYRGIAPNFMKVAPAVSIGYVVYENVRQILGVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKY5</accession>
    <name>A0A914AKY5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064248.1">
        <property type="nucleotide sequence ID" value="XM_038208320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208320.1">
        <property type="protein sequence ID" value="XP_038064248.1"/>
        <property type="gene ID" value="LOC119734768"/>
    </dbReference>
    <dbReference type="GeneID" id="119734768"/>
    <dbReference type="OMA" id="NCRPSYA"/>
    <dbReference type="OrthoDB" id="1874403at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287:SF1">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="333" mass="37303" checksum="7FD2D646BE7BDFFB" modified="2023-02-22" version="1">MSVFHLTSRLVQAQQASAPTNHPEEESIKAGRTAETDLINALRQQGVPSSHIFRGLRVPDGFQTRKYEIDIVVLTDYGLFTIEVKYWSGKVSLASDGKSWIHRKCTYSDKNSSVTYDEKSDDLIAELKLKTQLLRNHLLRKDVCLAEKYFHPRVVFMNKKIEIQDELVSKLEVVSSLRYQAFLQSFEKGLGWSVASAIIPSFLTGQLSYGAMEMARQALSSIGTWDVICLHGDRQLYGDFKGSAHFSPNREETGTLEFSHQRNASVSSLWAVLGYSPQVVVTMHKRCGGSWLWGTSCGSVTIPYNAEITFRVAGDQEDSKIPANDIQSINLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANX2</accession>
    <name>A0A914ANX2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065725.1">
        <property type="nucleotide sequence ID" value="XM_038209797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANX2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209797.1">
        <property type="protein sequence ID" value="XP_038065725.1"/>
        <property type="gene ID" value="LOC119735860"/>
    </dbReference>
    <dbReference type="GeneID" id="119735860"/>
    <dbReference type="OrthoDB" id="6153342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14314" checksum="A22295481B1BA16C" modified="2023-02-22" version="1">MGRKSSHILNVLQPCKTYHNASIKMPRMLKSCISFNIKDVRFVIFLTQVCCLQRVSCDLQALSVIGKPASQSMGYYPAGNAVDNDINTFSHGADGGDPHPWWRVDLLNEHCLGEITVTTRQGCCGKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APH2</accession>
    <name>A0A914APH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065930.1">
        <property type="nucleotide sequence ID" value="XM_038210002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210002.1">
        <property type="protein sequence ID" value="XP_038065930.1"/>
        <property type="gene ID" value="LOC119736019"/>
    </dbReference>
    <dbReference type="GeneID" id="119736019"/>
    <dbReference type="OMA" id="SWARENN"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037985024" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="219"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="360" mass="38933" checksum="6C61DB562173A689" modified="2023-02-22" version="1">MMDLRGIQFILCLSVLSSCVVAQISIQPLTDLTVNEGNTVLLDCALRNIPGNPDDILLILYHDGKAIVVNKQLAVNNPNYLLDTSVVGHWKLTIQEAQIEDQGTWSCQVQLPNEVSQQMRLVVLAAPVITSVTPDMAPMPGSMVTLWCNATGSPEPSVTWTRQRPAGNLPSGVEFVTGNPLVISDITNDWRGLYQCFVTNGIGQGAVTAPVFLQMEYSPIVRALNELVAAPIGDSAQLQCIGESFPAVKIVDNVQWFKDDRLVGASDGYQMSVSLDMDMDPYRETSIATLIVTAVSNQNVGKYTCRLQNLLGSAQADVRLEVGKQIDPETGASRSKASNVMAAMATIMAAIFMATVLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APH3</accession>
    <name>A0A914APH3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038065518.1">
        <property type="nucleotide sequence ID" value="XM_038209590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209590.1">
        <property type="protein sequence ID" value="XP_038065518.1"/>
        <property type="gene ID" value="LOC119735708"/>
    </dbReference>
    <dbReference type="GeneID" id="119735708"/>
    <dbReference type="OMA" id="NECKLTP"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="813"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="86"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120561" checksum="30C47B5EBF54B75B" modified="2023-02-22" version="1">MNGALIIGSRGFVFKRRVCDIFVRLQTHLSQYRSTRFAVQSQWPCSCRRRSLTEIEASSFVFRNAPILTFNMAQRSIMSFFSPKRQIGTTDKAASTGKTKDDRSPLKVKNGTSLESPVQQTHKKSRRILDSDEEDSSENVGGTSPTKTPPRKTTPAKTTPAKSTPMEDAPVEDTPKRKQATTAEQMTSDPVPPSPVTPSQPIPTASPMSTPGSIPLRKTARKHMRKRKAEEQKEEEGKDIATPIKGESESKKIKTEKSLTPVKASSKAAESSTEIDSPVSKVKDEMMDGVEEADDVTEAKASEEVKVEAKQAKKKEKSLKVKKSPEAKDKKAETKKTKTPPKKGSKREVLKPSTNNDEKTKTKPENSEDKTETAKSPKVKKELASPTSSKAASKKEEKGDKDEKTPVKKESKTPAKNVFGMFSKAATSDNMEYNPGASRYHPVNDACWKQGERVPYIALAKTFDIIEATSGRLKTIEILTDFLTSVMVLSPKDLEMCVYLCLNKIAPAYEGIELGIGETLLMKAIAQGTGRTMEKVKADAAQQGDLGLVAQSSRSNQRTMFTPARLTVLKVFNTLKEIATMSGNASMSRKIDKIKGLLVACRDCESKYIFRSLGGKLRIGLAEQSVLVAIGHAAVITPPGIASDSVSSKSKISDAMKKKMDDAALTVKTTYCELPNYGAIIPAMLEHGYEALPKHCKLTPGIPLKPMLAHPTKGVSEVLNRFQNMAFTCEYKYDGERAQIHLLGNGEIHIYSRNQENNTSKYPDIIKRLPNAYDSEKVKTCVLDAEAVAWDRENQQILPFQVLSTRKRKDAAEAEIKVQVCLFVFDLLFLNDEPLVTKTLRERRGLLHSHFNAVEGEFMFAKSMVSTDTEDIAAFLDESIKGNCEGLMVKTLDQDATYEIARRSHNWLKLKKDYLEGVGDTLDLVVIGGYHGRGKRAGTYGGFLLACYDDENEEFQTICKIGTGLKDEELDTHSKFFKAHVIDKPRPYYRHDTSHIPDHWFDAVQVWEVKAADLSISPTHRAAIGIVDPEKGISLRFPRFLRVRDDKKAEEATNSSQVATLYNNQDQIKNQKATGVLKPKASEDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR30</accession>
    <name>A0A914AR30_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065894.1">
        <property type="nucleotide sequence ID" value="XM_038209966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR30"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209966.1">
        <property type="protein sequence ID" value="XP_038065894.1"/>
        <property type="gene ID" value="LOC119735985"/>
    </dbReference>
    <dbReference type="GeneID" id="119735985"/>
    <dbReference type="OMA" id="TPELNEM"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="388" mass="45453" checksum="F5D8E78F7F3819F5" modified="2023-02-22" version="1">MDNALSIWNHNGSYTGHALHWAVRLHMWLWGYSEPCNIHLRMRGLYVHVLFSTYWGNICTCTWTFYVGLILAPWIVMEKYVTLEEFREVLSRRFSDEFPRVLSDYEGVPLFPEVDEVVKELKTYDVREDDCWVVTYPKAGTTWVQEIVSCVMHDGNLEAVNGRHTIFRVPYIDQTIPARARQWKSMPPIPKIVAEMPSPRVIKSHLPGQLLPPQLWQKHSKLVYVIRDPKDVIVSFFHFEKMFDPEKAEKSFADLYERAMTGKVMYGAWWDHYLYFWKRRHEPNVLLLRFEDLKKDLRGNIERVSLFLGKNLSAEILDAITEHCTFSNMKKNPIINMDTLYPHSIKTGGTFMRKGNVGGWKDWFTVAQNEAMDALIKDKLHGTGLTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS06</accession>
    <name>A0A914AS06_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066433.1">
        <property type="nucleotide sequence ID" value="XM_038210505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210505.1">
        <property type="protein sequence ID" value="XP_038066433.1"/>
        <property type="gene ID" value="LOC119736489"/>
    </dbReference>
    <dbReference type="GeneID" id="119736489"/>
    <dbReference type="OMA" id="DSNTIHY"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="224"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="489" mass="54894" checksum="A98739EBF70296CC" modified="2023-02-22" version="1">MAGVASLLRWSENQAPPGFQFDFVPDPVFDLFIGEGNILELDGTKITIRGSDLNNAQTSTEVRVFIGTQKCSVEVFDSSILTCEAPELEPEPLDYQGNRTSVELPAVYVLHSRHYFFIGYVRYITSVEIALYIGIAAAAVALALVALALFLYRKLRGKQKEIGAILIKMEKVEQAEDLRMENTTSESDGQQLELPTSAGTSAANVHHLHPGIGAEDAQIKFSQLQMGDKLGQGAFGTVYRAVLNNWSSGEQRIVAVKTVEDPDPPKVVQFLKEGLSMKSFNHPNVLKLLGLTFDRSGQPLIVIPFMANGDLKSFLVKQKQNLSHTHLTMFAYHVALGMEYLAEQQFVHRDLAARNCLVDDKLVAKIADFGLSRDLDESDYYTSGDKHAKLPIKWMAPESMERKVYDTKTDVWSYGVLLWELFSRGRTPYPDIHNRDVHSYLKQGQRMNPPRFCPTKISAIMRHCWLDSAKKRWSFGQIVQELEPLVTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASJ1</accession>
    <name>A0A914ASJ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Thromboxane-A synthase</fullName>
            <ecNumber evidence="8">4.2.1.152</ecNumber>
            <ecNumber evidence="30">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="38 39">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="33">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="34">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 35">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="8"/>
    <dbReference type="EC" id="5.3.99.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_038067030.1">
        <property type="nucleotide sequence ID" value="XM_038211102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASJ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211102.1">
        <property type="protein sequence ID" value="XP_038067030.1"/>
        <property type="gene ID" value="LOC119737035"/>
    </dbReference>
    <dbReference type="GeneID" id="119737035"/>
    <dbReference type="OMA" id="GIWQYAL"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="23" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 34 35" id="KW-0349">Heme</keyword>
    <keyword evidence="20 34 35" id="KW-0408">Iron</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="25" id="KW-0456">Lyase</keyword>
    <keyword evidence="22 37" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 34 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0492">Microsome</keyword>
    <keyword evidence="35" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="19 35" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 37" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 37" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="37">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="37">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="36">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="34">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="514" mass="58689" checksum="70EED49D07E7F4DD" modified="2023-02-22" version="1">MELLGFDLSVTWLLVIGFVLIAVWYDWWCHQYFQRCGIPVADYIPFFGNILQWRHGIQTTFTEYVKKHGRVVGMYDFRRPVLIITDPDILKNVLVKNFSSFYNRRKLPLGQKPLNRGLNQLLNEEWKEIRNVITPSFSASKMRLMSETINECCDTLVASLSKAQEGGKAADCRVLFGGFTIDAIAKCGFGLKVDSQQNKDDPFVKNAKKAFDFNLFNPAFMIVSAFPTLAPIFAYLKFDLFDPEVVKFFLNVTEAACNMRKQEGQDASKHIDLLQLMLNAHEDEEHEEEDTPTAESGQKKGAAHRKPLSTVDVMAQAITFFLAGYETTNTLLSFTAYLLATNQDAQEKLHAEIDNLAPTRDNLGYDVIAKMEYLDMVINESLRMYPPAVIFDRMCNETITYEGLTIEKGINVFVSLWTLHYDEEFWPNPTKFDPERFSPENKDSIKPCTYMPFGFGPRNCIGMRFALLEAKMALVRVLQQYRFDVCSETEIPPKLGKIGFLAPKSMKLSAVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT19</accession>
    <name>A0A914AT19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066496.1">
        <property type="nucleotide sequence ID" value="XM_038210568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210568.1">
        <property type="protein sequence ID" value="XP_038066496.1"/>
        <property type="gene ID" value="LOC119736554"/>
    </dbReference>
    <dbReference type="GeneID" id="119736554"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="125"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="488"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="754" mass="82077" checksum="A36A8FCEA9D97363" modified="2023-02-22" version="1">MAEPVCFILLVDKEVQGSASDSLLNQRHALSSKRILKGSLLQGYEVPPVGGQSYGDVVKGSNRADTKQFVVKPLSGDMQFQCSSWEIGRITVPERDLLRTIATNSDRFNIYQDMNLLPYALGLKEGSLVKVRHRNHSTSPYEEVAALVQYIGPLSETEMGTQFGLELMDDAYRGQGTSDGVLGKCRYFQTDPDCAVFVPISKLVPPSTSQGASYLYKNVSLSKQELPNQPSELTSVGDIKKGTTVYLQVGNGMRRGRVVYMIVPHKETEPHAVVEMPKQDGDRMWNGMHKGYHVYTPRNGVITTFVPVSDVTTHAPEASQAHKTDTSRVARSTTAASAAAPSRSESATGKGAAGTIPGASTLAEPTCFILLVDKEVQVSASDSLLDWRHTPFSKRILKGSLLQGHEVHVGMVGGLSYGDVVKGSKRADAKRFVVEPLSGDMQFQCSSLEIGRITGLERDLLRAISVNSDRFNIYQDSDLLPYAQGLKEGSLVKVRHRNDSVSPYEEVAALVRYIGPLSETKMGTQFGLELMDDAYRGQGTSDGIYGKCRYFQTDPDCAVFVPISKLVPPSTSQGASYLYENVPRSKQELPNQPSELTSVGDIKKGTTVYLQVGNSMRRGRVVYMIVPHKETEPYATVEMPKQDGDRMWNGMHKGYHVYTPRNGVITTFVPVSDVTTHAPEASQAHKTDTSRVARSTTAASAAAPSRSESATGKGAAGTIPGASTLAEPTCFILLVDKEVQVSTKNSQRLLASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATN1</accession>
    <name>A0A914ATN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066691.1">
        <property type="nucleotide sequence ID" value="XM_038210763.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210763.1">
        <property type="protein sequence ID" value="XP_038066691.1"/>
        <property type="gene ID" value="LOC119736751"/>
    </dbReference>
    <dbReference type="GeneID" id="119736751"/>
    <dbReference type="OMA" id="TATHIKM"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000185">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="512"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="613"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="712"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="807"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="903"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1270"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1446"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1556"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1783"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1892" mass="208056" checksum="AE8D03946C50CD2E" modified="2023-02-22" version="1">MAMGVFPEGLKTGLALNLRNKPTSQSTTFAADVPAENAVDGDRGTTSHTKEDPNQWWRVDLEAIYCLKKITILNRVDGWGGRLAGAVVRAGLDPSDFSQNTQIGDAVTSSQATNGAVIDFIADPIVSARYVSVKKNANGFVCLAEVMVEEIQDTEETSTVEGKTNENYEIGVDFTLVANPARLGQTGDDNAVIQAYKGSTYASAGIIFGRQLTTGGSNVELPAGSMVMDDPQTICNVTLSSTLPESAGIDRTGVFYAEAVKKENVTRIQTIILNKDDSTVHTRPTQRTQIANIGESVTLQMEDVNSPANSNYRWRHNGGDVIAAWNNQLNANIDNVAVDDGGIYSFSVADQESQQLHGFMRLIVRGCPAGMWGPPSCQNTCRRCYNGGICDDKTGTCICAPGFSGEYCQQVHGRHVFGQNASHTCSDSTDPHNDACRGRMFCLPDPYGCSCAAGYMGLDCMQECAEGKYGADCKQTCHCPSGDSCEKDTGECNGNCIPPYFGSNCQCSTDNGVLGLTVIADDPKQLQVSWQPDACVSGYILEYALTNRGQCEEIESPQWVSLPGLLDGQTTSHVITGLISSSTYMVYIRPQYSGTPGPNSTTSGTTLKDDNPSVSPVVVTSYDSTSVTLSWREVYCANYSVEYALQNKDGCETIDQLNFIQHCMCSGSNSTVIPNLLVNSVYEIRVRAFVDGSGGLLIQRSVTTGTKEPSAPPQQVTVTSTAKRSLNFSWRKPACGSRGGNITGYSYKLSGPGSQLISNVSTAEQVEIDGLIPFTNYSFQVAANNSVGVGPYSEVVVQRTDEAEPTVPLNVAIQNVDDVSITLQWSEPDPPQGIIIHYNVRYWRSEQPGNQTLINDVVQLMHEITGLETNVAYFLQVQAETSVGVGPWSANVTATTQIGVPGPVRNLRWTNTNESSITLDWDEPLKPRGSISHYIVRYRIFSPSEDYNMDEVENSPFTKNGLDPATAYEFNITAQNEKFEGFPHILVVYTKPQSNPAAPPKPPSYDSEATDTTVTIGLTKPTTGGQFVESYVVRVKRVGSVVKRDILVPNQFEDSPNDYIAAELLAQIAPEKFVIGDTQMYGGYYNAPLMTGESYEILTGSVSKGNESDGYVSYSEPLTVTAKKTTTEPPPPVGVIVAVVLVVVILALGLVVGFVVYKRRRASRAKQLSDESDIPLNAKASPSGKSSSFLEDFYLSSVHNYVNDGAAASDTPNKQKPKPTPKPRQKQGEPEPHAEEEGGEQVEFVPPPPVRRDELAEYIRQKEAQGDNGFLADYKSLPDFPLHPWTVAAKPENRAKNRYVNVIAYDHSRVVLDLLEGDPHSDYINACYIDGYKTENKYIASQGPNKASIKDIWRMVWQLGIDKIVMLTNPMENGKMKCLQYWADTGSTILSGIVVTTDKEEVFLDYTIRNFSIHPVGSEVAGRAVKQFHYTTWPDMKPPEYPAPLLNFLRLVNGHHNPGRTMVHCSAGVGRTGTFIALDAMQEQMAQEGQVDVLGFIYQMRQNRIKMVQTPEQYKFLYDALLSASLTGDTTYSVADFRQKLTTLKKKDKGAKETGLQKQFATLIQLSNRRVKVEKKSGQLPENKDKNRYRHIIPGDRSRPFLSTRVHEDETNYINATFLPGYRKKNMYIGTQMPMPNTVTDFWRLMYDHKATSIVMLNTFDVKDKTMCRYWPEKGTINFGKLSVELIQTKRSDSVTRCTFTLKNTTNAVLGKFNCPATILRENCLITQNTSQGILAGILLLPGRTSLSTANFVLSETVSINLLQSEEARTITQFQYHDWPSDQEILNSVPGMLTLMDLTRKWNGDKGPIVVHCMDGLGSTSVYCTLMALLEQFNVEKAVDVFQAAHRLRMVNQNMMNSLDKYALCYDVIQAMLDSTSIYENVTPSAGPESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU97</accession>
    <name>A0A914AU97_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mdm2-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067327.1">
        <property type="nucleotide sequence ID" value="XM_038211399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211399.1">
        <property type="protein sequence ID" value="XP_038067327.1"/>
        <property type="gene ID" value="LOC119737213"/>
    </dbReference>
    <dbReference type="GeneID" id="119737213"/>
    <dbReference type="OMA" id="MQQRYIR"/>
    <dbReference type="OrthoDB" id="8633268at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031396">
        <property type="term" value="P:regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039061">
        <property type="entry name" value="MTBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029418">
        <property type="entry name" value="MTBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029420">
        <property type="entry name" value="MTBP_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029421">
        <property type="entry name" value="MTBP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14382">
        <property type="entry name" value="MDM2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14382:SF1">
        <property type="entry name" value="MDM2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14920">
        <property type="entry name" value="MTBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14919">
        <property type="entry name" value="MTBP_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14918">
        <property type="entry name" value="MTBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="3">
        <location>
            <begin position="295"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="MDN2-binding protein C-terminal" evidence="4">
        <location>
            <begin position="633"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="103274" checksum="97E15191CAE39859" modified="2023-02-22" version="1">MPSKKCHLRPSFGDLCANSERYVILLTFEDVCGATRESSSSFLQEVFTNLSQINHKSDKLSIPQRRHRFAIVDPASCQNTDADWLTVDDLHTGSASTNGRRASGRVDGLPEGQDNSDKRETDEINTGGLDVAFSEAIHALADKLPLTGHYLDIIWLTTTSTDVPITSHISLYGALQRLCSWHAGLLTVVCEDATPDKPLNDTLNEWVNHLQGRVVRGGDWFAEAVGQGMAWRGEVTLADGKGQKSLCIPGLVLSSRPNDDSAIQVSTSADTSTCLSPQGKPSKSHAAKKIVTFSRQLEVVCSVRRADVPSIFVSPLQFSLHCLPSSRLPRSEHFLHWLREISQSHDSTVIMRLPCRTLTPNTRSNRNARPISTKAWKEHVKTCAGDLKVPDLHLHETQEFFYLLVHCDGKHSQDLVAQVMYSPRDLSGDVHAQLAEYQQSLTFDDLLGAGTTLKTVPSLEGHQVQTLLETIKLAQAEAIKAFLEERKSEGREPAMTIGELQQLMGTVYSIAMAEMGELSKTNKVDDDNDVEEDLRNENVISELDCSPSGWLQKLALQNHEALERKIKRFKSGEMMLAGMAVPAPADNTITLTAEEFLKHFLASGLPSTEDLSPISMALTSRADGVNTQNDCPGLSWDDLKKATFEQAQKYTHAGIQYFSDSGQSQKMDTRFSKMQQRYIRYETASTCSSDQAASPATLTLPQPSTSTTDPASDTVHPTSDTSETKGNPQRNRQNARGQRSAEKTQRSAEKGQRAADKGQRLMRLQRSAEKRRRMVLERNHKISPGRPLVRGLKRKGEVTVSPAKKRLVPTRTSPRKKVTPSVAQQEKPLSAKTNKESSQSSSTSSSKSRTMSRSEKTRMKLREVVKESLAGRGITKESKCYKACMERLYRMAEMYVKDLKSSKGLDEQMKSIAEANADFVVQFEQNRIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUC5</accession>
    <name>A0A914AUC5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067362.1">
        <property type="nucleotide sequence ID" value="XM_038211434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211434.1">
        <property type="protein sequence ID" value="XP_038067362.1"/>
        <property type="gene ID" value="LOC119737236"/>
    </dbReference>
    <dbReference type="GeneID" id="119737236"/>
    <dbReference type="OMA" id="PFESVHY"/>
    <dbReference type="OrthoDB" id="1099686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036873188" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="476"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="706" mass="78929" checksum="3805A6444C14BDA1" modified="2023-02-22" version="1">MDSSVMALILFFIGVHNGTCQSSTCHAQCDYDHVTARTDCSFRNLTCIPVNYPDSLIMDLSHNNISVLDDFSAGIFTRLVELYLDYNDIRRFSISVHETPFPSLISSQFNRIRNVRLHYHYSTRSSEPLDLKLDNNEIDSVDTEVYFNGDIKNVFKLSLSHNRLRYFRSTAVWEEVNMSSNGLRVWERISYFIEGRARIDLMQKLDISNNSFDSLIQPGWAEGLQILYADDNILANLSSTTLQGFTNLTELHLANNRLVFISSTALSQLTKLRSLYLDGNALTSLFGGIFLNQADLVEISIINNHLCDLHPDYFLGLDSLERLHLAGNRLVYVKSEMFRQMPGLVTMDFSKNTINVFDITNCSLLINLQNVLLAHNSIHDISYILGHCDNFEVLDLSFNQIRVVPGDSLTVGGRSRALSRLELEGNPLQCDCRLTGLRDWLLNNPPSVLPRCQGPPQNSGAVVTDLDIPDFICDPPKAVSKVNHLNVIVGQAATLSCTATGIPIPNITWLNPNSTVIPDKWQDRYFFSRGMTLHIISVELSDRGMYTCLVQNILGEFDRAVVNLTVSAELKSTHASVSLAAAVLPTMFITLIVTLAFVALVISLRRRYKKKDHCTSAVEGVRGGSRLSVGFRKTVSTRSDEGYVNEPIEGEYMTPTCKEDTGEEYEVPSTAAGHPSGRYQRHLWVIPSAGMDDADVYEPVNIGGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUK4</accession>
    <name>A0A914AUK4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066991.1">
        <property type="nucleotide sequence ID" value="XM_038211063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211063.1">
        <property type="protein sequence ID" value="XP_038066991.1"/>
        <property type="gene ID" value="LOC119737007"/>
    </dbReference>
    <dbReference type="GeneID" id="119737007"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32929" checksum="2F95BCC7CA7E65C5" modified="2023-02-22" version="1">MALSTHKYHEAHSVYRRLTNREKTLIEWFHGNTQSLLDNAFAVSMSQDTDVKVLSVGAGDGHVERPIFSCLRDSLGYSKMNATIVEPEASSIQRFQDLVAKEPLHGVNFDWRCQTFQKYDKSEEAMGDKFHIIACMGSLYYLGDLNEVLKNLYSRLEDGGILLLGVAQGGIGFGKLVQYLQTKLDNGACAERYSSWEVQDACKNLNMAVSQTYIIEAYLDISMCLDKPPDQLSQDALAMLDFITYREDFVRRAPPDLLGEVLRFLGSECTERGPAGEFLLDESTALLVIRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUX5</accession>
    <name>A0A914AUX5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067562.1">
        <property type="nucleotide sequence ID" value="XM_038211634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211634.1">
        <property type="protein sequence ID" value="XP_038067562.1"/>
        <property type="gene ID" value="LOC119737343"/>
    </dbReference>
    <dbReference type="GeneID" id="119737343"/>
    <dbReference type="OMA" id="MCISFVE"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="123" mass="13433" checksum="D25163FA084F51BF" modified="2023-02-22" version="1">MDKFRTGVHNNVAAATPSSGTYISGSASTPTPTATTPSGAPAGVTPLSSAWKTTLAATTTVSTMSRRRNTYNKKKQHSGTSLRPPRALFCLTLDNPVRRMCISIVEWKYPFEILYVMMEFTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUZ3</accession>
    <name>A0A914AUZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067111.1">
        <property type="nucleotide sequence ID" value="XM_038211183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211183.1">
        <property type="protein sequence ID" value="XP_038067111.1"/>
        <property type="gene ID" value="LOC119737093"/>
    </dbReference>
    <dbReference type="GeneID" id="119737093"/>
    <dbReference type="OMA" id="WEINAES"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="94" mass="10965" checksum="D64E6005AF597E1B" modified="2023-02-22" version="1">MHESDYYTSGDVQAKLPIRWLAPESMERRVYNARTDVWSYGVLLWEIFSKGAKPYPGIPNQDVYDFLKRGQRMDAPKNCPPEMYVQTAVTITFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX85</accession>
    <name>A0A914AX85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein FAN</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068745.1">
        <property type="nucleotide sequence ID" value="XM_038212817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212817.1">
        <property type="protein sequence ID" value="XP_038068745.1"/>
        <property type="gene ID" value="LOC119738083"/>
    </dbReference>
    <dbReference type="GeneID" id="119738083"/>
    <dbReference type="OMA" id="QVYKRRY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="181"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="283"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="785"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="827"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="908"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="106669" checksum="FCE6F34774421C40" modified="2023-02-22" version="1">MAFLSEVSLQKERFSLLLLEPGEIYFEDFSVFFYPSDLPEEEAIRRRTRGRLKVCSKSIVFDPQDVSQPVVKFPLRECIQIDKWTGPLLSRLGNRGDVIVIQCKQKIEMKANNIIGSYEFKKETTKHLFSLNYVTPDDVLQMMCQLHRASTLPLADEAGMIAAIVYSCYNRTKFNTSWLETLYEQIVMETVGDHITPLVVNPGRIMLTSSRLYFQPFNNVESVPVIKIKLSDIKRLTKRRFLLREVGLEIFCTEGSFKSDMFLAFSKPEDRNKLYKNILAQEGVSLKESAQENMTLLWQNGVISNFDYLLYLNSQADRSFNDLTQYPVFPWVIADYISEELDLTNPETFRDLSKPIGALNPQRLERFKERKVDMPEPKFLYGSHYSTPGYVLYYLLRVAPEYALCLQNGRFDQPDRLFKSVAETWSNVLSLPSDVKELIPEFYQPEMADFLINRSGLNLGVQQDGSKVNRVELPPWADDEVDFCRKCRKALESDHVSNHLHHWIDLIFGYKQRGPEADEADNVFYYLTYEGAVDLDSIKDPNEQASVKVQIMEFGQTPKQLFTKPHPSRFSPAVPVSRHSNNSSPVPVPQPVEEESANERLRSDSDAFTDTHTDTQDLEEDTASAIQRKGSLLSHQWDRMDQLQPACQHKLHKDTVKDVQVSDDGKTVFSVSQDTSLKLYSLEDQRQRRSISISSMPLSSLSAMPDGKTVLVGSWDDSLYLYSIEYGRIVDKLMAHDDAVSALHLQGEVLVTASWDSTVKVWTVEDLCGQSNGTVRLNSVQMTAEFDHETGVSCLDVNGDNSLVLSGTKDGAVYIWDVGSQSVLRSSMSHTGMVHDVKFSPDGKMILSAGEDRFMRVVDVGTGTEVFAKETEHEIRCVCWRENTVLAGSSSGELLVWDMVKAQLTATIPGHDDAISCIQATSDGHTVVTGGTDKKVIVWKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXA1</accession>
    <name>A0A914AXA1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068313.1">
        <property type="nucleotide sequence ID" value="XM_038212385.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068322.1">
        <property type="nucleotide sequence ID" value="XM_038212394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212385.1">
        <property type="protein sequence ID" value="XP_038068313.1"/>
        <property type="gene ID" value="LOC119737782"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212394.1">
        <property type="protein sequence ID" value="XP_038068322.1"/>
        <property type="gene ID" value="LOC119737782"/>
    </dbReference>
    <dbReference type="GeneID" id="119737782"/>
    <dbReference type="OMA" id="ADEISFX"/>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1440:FF:000001">
        <property type="entry name" value="phosphorylated adapter RNA export protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="45216" checksum="32647DE5C8B3F1D5" modified="2023-02-22" version="1">MASYRDVRPVSTNSSDDSSGDSNSDSEEDQPWKRRKATSQSQGIRSQKQHPIGSDLKQDAPKVAPGNSSQAGVKRPRRNNVWGEVVQQQNEALVAREMDEFGMDLNRSRDVESYNYKLDTEENASRVYLGAPSVSKPESNQGRNLKRGIGEADDDSWLVNPQRNQTESGERKPVHDRLGERVPSHRPIAKARLGSRVESSDVTPMKLITIDPALSKKEITGKLAYSLQEPKRELIVRVVDTLGVEKSLELWNLTADIEKDGGMMILNGSRRRSPGGVFLQLMKTDPQVTKEQVNKIFAEERKNENEQKHKRERRRKRKKTVKFKEEVEEAVPRGDEEATEVKEERRISEEDEGPSVREAEEVQLKREGQGLEMEDGEIDDEEEKQEEKTLIQEEQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B164</accession>
    <name>A0A914B164_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine and histidine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZFTRAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069648.1">
        <property type="nucleotide sequence ID" value="XM_038213720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B164"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213720.1">
        <property type="protein sequence ID" value="XP_038069648.1"/>
        <property type="gene ID" value="LOC119738766"/>
    </dbReference>
    <dbReference type="GeneID" id="119738766"/>
    <dbReference type="CTD" id="609854"/>
    <dbReference type="OMA" id="HERPEHE"/>
    <dbReference type="OrthoDB" id="10062218at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16505">
        <property type="entry name" value="RING-HC_CYHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039338">
        <property type="entry name" value="ZFTRAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059:SF4">
        <property type="entry name" value="ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40340" checksum="962999EE127287C3" modified="2023-02-22" version="1">MTEPEMSVPGAVNLIENPGVSSQDVVDCSEPPLKKSKTEVVVETEEDPQEEDLEQRLNDILCCSVCLDLPINLVYQCVNGHLMCAGCFTHVLADARLKDEQSTCPNCRCEIGKTLCSRNLAVEKTVSELPALCPHCSCKLPRNVLEHHQRSECPQRVSKCGYALIGCDWKGPNCEVKGHEKDCEYPGKTGADVMAYVEESNQSLQSEIRSYQNIVNLLSFEKLAFNDLQLRPYRTDDFITKLYYETSRFSALNQQWVIKARINDRERNPLHTADRHLTYQLVLKSRVNNPIAFHFMLLSGPFTDIKVEPAVYRFEFTGDRTESPHQLMPLTNPANGNKLLSAKTINVRLIMFQVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1I0</accession>
    <name>A0A914B1I0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069351.1">
        <property type="nucleotide sequence ID" value="XM_038213423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1I0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213423.1">
        <property type="protein sequence ID" value="XP_038069351.1"/>
        <property type="gene ID" value="LOC119738521"/>
    </dbReference>
    <dbReference type="GeneID" id="119738521"/>
    <dbReference type="OrthoDB" id="538816at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037734681" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="241" mass="27590" checksum="95E742847ACCC2B0" modified="2023-02-22" version="1">MSWFLENLILILFLLLLVSNRSFLQASCPPGWLKWRQSCYIRLPNRMNWFEASEACNRPGGSMIVPNSKEENLFIWESLVTGTGGLWIGCTDAAQEGVWLCDGQPAQYTNWHPSYPSRSNKRNCARISTYEGWRGVDKTLCNRQRFAACEMTPSSVPAYHTFTGPDGRVPQRCLLHHDIKNLTAEGLLACGWACRADPRCRSFNLWQSNKKEKMCQLNDVTRLVADDNDFKATDNCYFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2I3</accession>
    <name>A0A914B2I3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069711.1">
        <property type="nucleotide sequence ID" value="XM_038213783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2I3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213783.1">
        <property type="protein sequence ID" value="XP_038069711.1"/>
        <property type="gene ID" value="LOC119738817"/>
    </dbReference>
    <dbReference type="GeneID" id="119738817"/>
    <dbReference type="OMA" id="HYTHAFL"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037826251" description="DOMON domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="267" mass="28316" checksum="7523639661198581" modified="2023-02-22" version="1">MSTAYIPNALLHYTHAFLTLALLIRLGAPQIAVDECGVSKGCFRSPVDCDSLTSCDVIVTWQETPDGGSLIFELAGMSPGYVAVGFSGNQLMSSTDVLACVDNNGATLKHFYNPVSHVNEPRTQIGVTDEAASSANGIIQCKFTRVKFLDGQPEFADLREDTYVLLARGRQSGGFLTYHTLGYSISGSKQDFSIYRAPDALPTVHPPGEGNSTASTQVPAGPTDLDATDGSHGLTSPISNGAGRQYGFTTTIIMVTLISISCLLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3E9</accession>
    <name>A0A914B3E9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070031.1">
        <property type="nucleotide sequence ID" value="XM_038214103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214103.1">
        <property type="protein sequence ID" value="XP_038070031.1"/>
        <property type="gene ID" value="LOC119739246"/>
    </dbReference>
    <dbReference type="GeneID" id="119739246"/>
    <dbReference type="OMA" id="NYICESF"/>
    <dbReference type="OrthoDB" id="6051114at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF227">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="30869" checksum="8BD75DDEDB711FE0" modified="2023-02-22" version="1">MQLLTALRFFATGSFYTMHGDLHDMSAPSVSRIIHRVCRAINREANRVIKFPVRQQDVNRAQRDFFAIAGFPQVVGAVDGSHIRLYGAPLMDDEHLYVNRKGWHSINIQVICDANYLITNVVARWPGSTHDSAIIHGSVIGDMFSDGRLQGMLIGDSAYALRPWLMTPIENPITDAERNYNRCHRRTRVKVEQTFGQLKRKFPCLALGLRVSPSRACQIIKACCILHNLAKIMGEPDFEEEVEVEEVGALPYVGVLHDGQAHRERIIRQYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6R4</accession>
    <name>A0A914B6R4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071896.1">
        <property type="nucleotide sequence ID" value="XM_038215968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215968.1">
        <property type="protein sequence ID" value="XP_038071896.1"/>
        <property type="gene ID" value="LOC119740607"/>
    </dbReference>
    <dbReference type="GeneID" id="119740607"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="419" mass="48168" checksum="59C932BCB2F1AC37" modified="2023-02-22" version="1">MAEEGTRPAVLERITDDHLKCSICRELYKELKTLSCLHRFCMQCLVTYRQSHWDSDHLMCPLCRQQTSVPGGDIRNLATDFAPASLEEVVQKEYGPTIQTCSIHEQGKCELFCETCTKLICLTCLTESHKRHEFKEVRRMNIADKRKRIKDKIPQYQKSVADLTQALQSVDKEKRDFAVAMVRLKEEVEGEARVMKDKVDDSKRSILRQLDQIQTEREKELKDFSHDLNFMRKTTQKLLDESNLVLETNHQYVFLQKYTSTGMGSLGKNRRRIPSMKNNPVVTFTPCEKDIPVGKVLKHSTIFKIKGLMIDLVWFLKMVMIAVVMFIGLVTCVEAMVGITTKMAVLSLVVMLCILKNLIKIGAVHKMKSKMKAVVKFLSMVMMRVVMLMMLVTLVVMMIGKTTIIAMMCWVITSMFCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7W3</accession>
    <name>A0A914B7W3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072261.1">
        <property type="nucleotide sequence ID" value="XM_038216333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7W3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216333.1">
        <property type="protein sequence ID" value="XP_038072261.1"/>
        <property type="gene ID" value="LOC119740875"/>
    </dbReference>
    <dbReference type="GeneID" id="119740875"/>
    <dbReference type="CTD" id="51073"/>
    <dbReference type="OMA" id="WIENTDA"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="332" mass="38145" checksum="F3E018546928E531" modified="2023-02-22" version="1">MLSRFTRISRLCNNCSVFRNFSDPPRIRKSLFTTARHLQQSDQGTNQGENLIQVVNTEFESPERWQNLPLMTGRPVDAPACLEKPQAWLETISTLENIKLGMVDLHPDVFATMPRIDVLYRNVLWQRDYKRISLAKTKTRAEVRGGGRKPWRQKGTGRARHGSIRSPIWKGGGRAKGPRGPRSYWYELPVKVRAHGLRVALTVKLAQDNLHIVDSLDLPSPEPQFLEDVAMQRHWGGSVLFVDNKPIQEMPENFLQAVSGIKTYNVLSTEGMNVYSMLKHHTLVLTLDAAEFLEERLLFYMRCYRKKDIVDTHKILFGQLKILPSKKITTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA16</accession>
    <name>A0A914BA16_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072839.1">
        <property type="nucleotide sequence ID" value="XM_038216911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216911.1">
        <property type="protein sequence ID" value="XP_038072839.1"/>
        <property type="gene ID" value="LOC119741191"/>
    </dbReference>
    <dbReference type="GeneID" id="119741191"/>
    <dbReference type="OMA" id="GINDYKW"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037480291" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18695" checksum="97D4FEBFB420A21F" modified="2023-02-22" version="1">MGRYLLALVCFLAVGLSSVQAAVTPYCCPHYWTLRGNRCYRFIGKAMDWHSAQGHCKGLDHKANLVSLNTAGEEDFILHMWAEKGSRYDRLWVGFNDLDWEGHYKWVGINKPLDYTNWLREQPNNYGHSQDCGAIHTISGYWNDETCTRKYAFICERPRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAU3</accession>
    <name>A0A914BAU3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073139.1">
        <property type="nucleotide sequence ID" value="XM_038217211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217211.1">
        <property type="protein sequence ID" value="XP_038073139.1"/>
        <property type="gene ID" value="LOC119741456"/>
    </dbReference>
    <dbReference type="GeneID" id="119741456"/>
    <dbReference type="OMA" id="FDMQINP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="132"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="260"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="998" mass="112697" checksum="2CFC1FE4DAE9E93B" modified="2023-02-22" version="1">MAISAQRLRELPGNDRCADCQDCDCPECGFPDPVWANEELGILVCEECMDLHYMLNKASFKSILCQDWTEDSYKKMASKNNRASNEYYEKHLCPAYKKPTRCFNVEFRRQWIMSKYPHKEFVSADDQPKYMQGQKSGYLWKLGRDSQVFQRRWFVLDPSEKGTLRYYTDANEQSLRGEISLFKMNLVLASSEKIGHPNGLQIVYPDKKGQNNTRMIYLYAELAKDMVEWFQAVRCLKYFIQKRKSVETDENIISRILKYDILKEGYLFKTGSKGKEAFRKRWIVLDKLCLMYFKDPLDANPKGTIPMKGGYSLILSGQLDPEHQGFHFYLKTPGRIYHFIAESDHERKAWFNAIHAACNRASGVISHKGGPKLVNEKWVTKSSPAQPTASTSKPKVCPPTEATVSSSTPGDSISNISKSVKTSPIAAGATGGTSGEDSPELDGSFEILSAPFAGIRPSTKPRPQHTLPAHHKRGGGRGAGGQGRYNQAELKHQPAVEIPEDNYIEFTTEEGEPLDEEDTEESSDEDEESPYVELDGEKVVMMQKVDMIGMTTKQLSTHLKVPRKALPQSSSCTMCVSLVWDTLPNLPESEACVLVSPIVSCCSMPRNVTLLQPFQLEIQHSAILKDVDNCTPNIWHLNKEPGKFFKWEKVDQTSFSVACRASHRHFVIETAKTGCFAVMVPTDSVSGKIIRCMTYISSEQSDDHLVARVYFFGDNGSDDVLHEIQRRENTYRGRLCDISGSFFLSNTSDNVLMNMTNLEGMERYLGGNEPMPITTEELYHKQLVCYMVEIIKKEPVGQCTINVWQENTALEQRPVHMNLQFSNEAKYPVIAPVPFLHTHMPPPTTIPVRCHQAVSRVSSAPLTQKASPSLVADRPRDAPHARSVPSRSRAADALLLKASDGSLQHNMLPFAIKRDLFLLLDPKLPSGNDWRMLASQLGLDAMIYYFDMQINPTMEVLKAFEIMNRPLSELEEQLRLLGRDDAADVVKMHLEKTGKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC53</accession>
    <name>A0A914BC53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073606.1">
        <property type="nucleotide sequence ID" value="XM_038217678.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217678.1">
        <property type="protein sequence ID" value="XP_038073606.1"/>
        <property type="gene ID" value="LOC119741782"/>
    </dbReference>
    <dbReference type="GeneID" id="119741782"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038056356" description="ZP domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1272"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1387" mass="153963" checksum="9B3193BB4D5FB1D3" modified="2023-02-22" version="1">MRRVLLLVVCLASSFIEPAVSRNVGHYKGGSITWKADEDNPSNVVVFYRLNFRHHYENGYLHTQCTDQAVQDRSVLNTEGSFRVDGRWISWAKYICTDYDDEMDWSAGYFIMPYTLEPGQTRVDVNFEECCWPTTVGNNGNDQGNGRGWNMVSTVDISRRPDTGLPNSPPVAGSFPVYRLYRGCKYTRYIRAWDADGDDLRCRWTDPNRNECNANNGDICGELFVNSERTKKGAILEEDTCKITFNRRNPAGTYAVAVMVEDYAPSDPTTPLSRIPVQFLIEVHNRDGKCRKPELLGEDGTCTTIPAGRETRIPLRARSSSLDYAITSFETIKPSGVHVSPLRRVHGSNDEYTVTLSWIPTRDQIGRHVICYEAEEDHKFSSDMFCIYVNVVDAADFGPQLAVDPYESTPAPGARLRGETVTIAYSREIRKSPRHAFISILDASNNPIYQIDSSSSEITVSGKTMSFSLPYDLPLQRGVAYKVRVDEGAVKSAMDCEAAPQGDEWMFVFESFCDGDNSPLVVSPVDSVPAPGTEMFGNVVSVTYNKKIQKPSTSAYITIVDRRNTPIFRIDTSTADASVSGRTLSFSVPLTLPLEYQGWYRIRIDEGAVVSARACEQGLPPMAEWDFVFVTFCSDEEVYEPLTVLPSQSVPSPGENFAGQTMMIRYNKEIQKPVDSAYITILDAFYLPILQVDTSTQDVTVSGNTLSFVLSMDLPLQFGGGYTIRVDEGAARSAQDCDLIPPPSAEWEFGFVTFCADGGDYEPLSVLPMESSPFPGEKFAGRLMKIGYNKQIKKPFRPAYISLFDSADSLLFQIDATSPAVSIVDGTSLGFTLPLDLPLAFQGVYKLRVDGWAAVSVLGCDVSRPDSAEWRFTFLTFCEDGGDSFEPLAVLPMESLPRPGGNITGYELKIQYNKPIQKPTSPAHVRILNSEDSAVYEVDTTSDEVTIEGSALKFSLPAAAAVFFGSDYRVMVDQGAARSALECDTTLSDTADWRFKWTGRRLPGEIIDKPVVSTSPHGNADCRENFMQTFVSKRLVGEIDPASMYLNDKSCTGRHYNKTHYVIGTSYDACQTEPEVTANGRKMAFRNVVFIPPQPYTPGSEITRDHFIEIHLTCHVPTDRVSYLSFDPNVTTIVYYEEGYGNFNFSLKMYEDESYRRAYRPREFPVGVQLNQAMHFEGRVTCNGDCDLMIDTCWATPTSNPFDLTRFPFITNGCPIDDTVALLDSPSSQKERFAINSFAFLGDNIHGTVYVHCDMRICDVNDPNSRCTMGCDSEDQSPTEAQSEDNNELRPEAPSRGDVPHSELVFGRGKRDVSRVGSSSAAYPSTGGQLRLGGEQIDVKSNQSLAVNPDVVEIAMLGAIMLLLLVLVAMQCRRTTRATGKASMSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDU6</accession>
    <name>A0A914BDU6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074234.1">
        <property type="nucleotide sequence ID" value="XM_038218306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218306.1">
        <property type="protein sequence ID" value="XP_038074234.1"/>
        <property type="gene ID" value="LOC119742401"/>
    </dbReference>
    <dbReference type="GeneID" id="119742401"/>
    <dbReference type="OMA" id="MRKRNRT"/>
    <dbReference type="OrthoDB" id="10354602at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="153" mass="16680" checksum="72F19645B9298CE4" modified="2023-02-22" version="1">MAPGYETGTESLPPSTNLMTEDAPYQLLPHSTAGVGWDDNAGLTKQSPAENTIPRAGDDVFTPSQYTWNLIIGITASVVFVLVTIAALFGLIAFKRYMRKRNRTLSADTGVFSPRRGSKAGLDMIDNAVVLTSHSSLQRSGSLRKQFQKFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF64</accession>
    <name>A0A914BF64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074576.1">
        <property type="nucleotide sequence ID" value="XM_038218648.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218648.1">
        <property type="protein sequence ID" value="XP_038074576.1"/>
        <property type="gene ID" value="LOC119742566"/>
    </dbReference>
    <dbReference type="GeneID" id="119742566"/>
    <dbReference type="OMA" id="NPCAEGV"/>
    <dbReference type="OrthoDB" id="406708at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008297">
        <property type="entry name" value="Notch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002279">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="40"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037723656" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="459"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="606"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="685"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="764"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="803"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="843"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="882"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="922"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1236"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1313"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1353"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1392"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1431"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1470"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1548"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1593"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6 7">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6 7">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6 7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1459"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1536"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1621"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002279-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1691" mass="175010" checksum="35E2741BD65F78B1" modified="2023-02-22" version="1">MDMTNPLVVVLLGLLMYGCHAQDHPCDDGSNPCMNGGFCFSLDGVAPMCGCVGDYVGNDCSYVNPCSDRINPCLNGALCSPSMVDLVAVCTCTADFIGIHCETENPCKAGANPCLNGATCSVSNTEAVCECADGFVGAFCENVAQCPDSNNTCANGATCILVDSTAVCLCPRGFVGDNCQRAHPCAEVMNPCLNDGNCYSTDDVTVLCSCVMGFTGAHCELAPLCHASINPCMNGATCLEEDSAAICICAEGFIGDYCERVHPCALGFIACMNGGSCFVADDGLEARCTCVNGYTGTLCQEVPPCHDTINPCTNGAMCVEEESAAVCICAEGFIGHNCNTVHPCELEENQCLNGGNCFSTNNVTAKCVCMDGFTGLRCEIAPPCHDTVNPCLNGAMCLEEDLAAVCICAEGFVGDNCERVHPCTASVNPCRNFAECFSPDGITTKCVCAYGLTGDYCQIVPPCYPSINPCLNGATCLEEDSATVCICAEGFVGDYCDTVDPCSAELNPCLNGGSCYSPDEITAKCACPSGISGTICEIVPPCHESINPCVNKSLCIEMNSTAVCVCAQDSSGSDCQEAQPCQFLLLQDVTSKCVCTNSTSATTCKKVPPCHDSINPCMNGATCAEEDSAAVCICAEGFIGDYCERVHPCAPTADSCLNGGKCFSKDGATARCSCLKGISGQFCEIASPCHVSINPCLNGAMCVEQDSAAVCICAEGFTGVNCERVHPCAAGVDPCLNNGICISTDQLTAKCMCINDFTGLNCETVPPCHDSVNPCLNGATCIEDNVEVFCVCTEGFAGNNCERVHPCAAGANPCMNDGECYSTDDVTAKCACPDGLMGMRCERATPCYHSINPCRNGATCVEENSSAVCFCAEGFVGNHCQRPHPCAAGVNPCVNGGTCFSIDDLTAKCACMDAFIGTHCEYVAPCSVFVNICANGATCVPDVPTPRCICADGYVGDICDRVHPCLAEVNPCLNGASCFSMDDITAVCSCVDGYTGEHCEMVPPCHESVNPCVNGALCVERDSAAVCICAEGFVGDNCETVHPCADGVNPCTNGSNCFSVDGVTAICACVNSSTRQECENVAPCHESINPCRNGATCLQHNSKVAACLCPEEYIGAYCERVNPCAEGVNPCLNSGNCLPNIQAACVCVDGFMGVHCEIAPPCHPSVDPCLNGATCTVVDSAAVCHCADGFVGANCENVTPCHASVNPCLNGATCTEINSTAVCQCAFGFHGANCQDVSTCDESRDPCMNGATCLVMDSRIVCQCAEGFIGINCARVNPCAEGVNPCLNGGNCFPNIQAVCACVNGFTGTYCEIAPSCHASINPCLNGASCVDVDGTAVCMCTDDYEGVHCENRTPPCHPSVDPCLNGATCTVVDSAAVCHCADGFVGANCENVSLCHASINPCLNGATCTEINSTAVCQCAFGFHGANCQDVSACDESRDPCMNGATCLVMDSRIVCQCAEGFIGINCSRVNPCAEGVNPCLNGGNCFPNIQAVCACVNGFTGTYCEIAPSCHASVNPCLNGASCTDVDGTAVCMCTDDYEGVHCENRMDPCHESIDPCQNGALCTVVNSQAVCNCSSLFSGPTCGNAVLSLDVSSCSGSINPCLNGGTCVEMESGVICVCPGGFSGLNCNLADPQELVLEEPVAVDSHRRGVSSGQEDSDDSLSNAASSHGWQAATLLVLATVSIMLCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG13</accession>
    <name>A0A914BG13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Thromboxane-A synthase</fullName>
            <ecNumber evidence="7">4.2.1.152</ecNumber>
            <ecNumber evidence="29">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 33">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 34">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="7"/>
    <dbReference type="EC" id="5.3.99.5" evidence="29"/>
    <dbReference type="RefSeq" id="XP_038074810.1">
        <property type="nucleotide sequence ID" value="XM_038218882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218882.1">
        <property type="protein sequence ID" value="XP_038074810.1"/>
        <property type="gene ID" value="LOC119742715"/>
    </dbReference>
    <dbReference type="GeneID" id="119742715"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 33 34" id="KW-0349">Heme</keyword>
    <keyword evidence="18 33 34" id="KW-0408">Iron</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0456">Lyase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 33 34" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="33">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="51311" checksum="282751E79DD8681D" modified="2023-02-22" version="1">MELKQDGMGFQIYKFQYPILFVSDIDIAKRVLVTDFNKFPNHWDIPAAGFPLNGTLLYMKGRRWKDVRAIITPAFTASKLRQMVEIFSDCCGPLLDNMGKSHAENKPLNTKKNYLGFFIQTIMAIIYGLDVQCQANLDHPFVTKVEKAFQPSMITLIPIIFPILGPLFEMMGSNIIPKDAVNFFKKIIEDSFQGGVQIRQRREGAAGYVTMNEMYQKNTEFPGDVPTEEELAKEAAGKPKKLTYNEFLCANVILLSGGNEATSTFLVCATYQLALSPEVQDKMIEEIDRLAPTPEDITYETMSKMTYLEMVIQECFRMYPPTLLADRVCAETVTYGKYTLKKGLLVNIPFYPIQHDGDIWADPEKFDPERFSPQNKDSVNPLGWIVFGAGPRICIAVKFVMLLAKVFMTRVFQKYRFEACPETPIPLTFGKMTMLEPQNVFVRVMPRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH23</accession>
    <name>A0A914BH23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FGFR1 oncogene partner 2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075189.1">
        <property type="nucleotide sequence ID" value="XM_038219261.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075190.1">
        <property type="nucleotide sequence ID" value="XM_038219262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219261.1">
        <property type="protein sequence ID" value="XP_038075189.1"/>
        <property type="gene ID" value="LOC119742972"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219262.1">
        <property type="protein sequence ID" value="XP_038075190.1"/>
        <property type="gene ID" value="LOC119742972"/>
    </dbReference>
    <dbReference type="GeneID" id="119742972"/>
    <dbReference type="CTD" id="26127"/>
    <dbReference type="OMA" id="VCRMLMA"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186:SF2">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12186">
        <property type="entry name" value="SIKE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36478" checksum="A9A7FC44CA61B8B6" modified="2023-02-22" version="1">MSLTIEQVLDDAKRLVDRLRDHDNAADSLIEQSTTLNKRIEAMKQYQEEVEEMNNVARHRPRSALILGIQQENRQIRELQRENRELRVALEEHQSALDLIMSSYREQVCKMLMANRFDRDCLEKHAEYHENSIASTAKIIEMAAVMKQAIELEEKSSFDTEQQLTRLQVENRGLRELLEISRAVHFRHSPIHHEEKTDKEKDPTPLIVNNEGANNLPDSKSQTPENDQLPKTNSGTGSEKLVDEAKDTNEKKELIEVEDTSAHGGLKSTENATDEKERDESGDVSAQGEGAVDLEVEDVLNDFADMTASLDMGDDEDESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH96</accession>
    <name>A0A914BH96_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075638.1">
        <property type="nucleotide sequence ID" value="XM_038219710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH96"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219710.1">
        <property type="protein sequence ID" value="XP_038075638.1"/>
        <property type="gene ID" value="LOC119743306"/>
    </dbReference>
    <dbReference type="GeneID" id="119743306"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="133" mass="14286" checksum="C615DF588B338FD7" modified="2023-02-22" version="1">MMEPSTSLNGLPEPESPRHQQESLQLQLQQQQQDTLPFGVQPTDQLQASVAGVEQSTTAQEESQSNNRTTNPLTWKQQQGWLDQSQPSDVPLKPLTSMSDAQPAEIAPAPLAPSSSSNTGGLPGNAALQTQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BID7</accession>
    <name>A0A914BID7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075665.1">
        <property type="nucleotide sequence ID" value="XM_038219737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BID7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219737.1">
        <property type="protein sequence ID" value="XP_038075665.1"/>
        <property type="gene ID" value="LOC119743334"/>
    </dbReference>
    <dbReference type="GeneID" id="119743334"/>
    <dbReference type="OMA" id="MACAHSS"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="246" mass="26339" checksum="2D774579CACEC749" modified="2023-02-22" version="1">MMTTTNAPPTYVAAPQPFGQQQTVTVQPAPQPRSGNWKGILWTGVIQGVLGSLTAICGVVSLVVFRPALYINDFGPPIWCGILFYVVAGILGMVSGSKKNSGVAIGYMVMSILACLATCCVIGFAVVWMLALNSICSPRYYPYGSYYYHDVDVRPYNGVYGTLILLAIVEFIVAIVGASMTCGPLCSGESATQTVIHYQARPQMVVTTQPQGPAFYNISAGQHRVAQQGQYLQAQAPQPASKATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ44</accession>
    <name>A0A914BJ44_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076129.1">
        <property type="nucleotide sequence ID" value="XM_038220201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220201.1">
        <property type="protein sequence ID" value="XP_038076129.1"/>
        <property type="gene ID" value="LOC119744329"/>
    </dbReference>
    <dbReference type="GeneID" id="119744329"/>
    <dbReference type="OMA" id="CSESINH"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972893" description="Cathepsin L" evidence="5">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="109"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36466" checksum="7D96994D37A32AF8" modified="2023-02-22" version="1">MKFLILALCVAAALATSPDLDQEWQMWKDNNQRKYEVEEEDYRRFVWEYNYKIVTEHNQRYALGHTTYTMAMNQFADMTNVEFRKRMNGFVSAIAPLETTQSRIDVSPLPDFVDWNSKGWVTPVKNQGQCGSAWAFSATGALEGQTFNKTGKLPEISEQNLVDCATAPKYDCAGCNGGTMLGAFQYVIDNMGIDSESSYPYQAQDMKCRFNAANVVATEKTYVVLPSGDEKALQRAVATVGPISAAIAASHVTFQLYQSGIYDEPQCSQTALAHNVLIIGYAIENGNPYWLVKNSWGADWGMNGFVRMSRSKDNQCGIATRACYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJG4</accession>
    <name>A0A914BJG4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075582.1">
        <property type="nucleotide sequence ID" value="XM_038219654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219654.1">
        <property type="protein sequence ID" value="XP_038075582.1"/>
        <property type="gene ID" value="LOC119743251"/>
    </dbReference>
    <dbReference type="GeneID" id="119743251"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="253" mass="28193" checksum="77E3542C766801F6" modified="2023-02-22" version="1">MADTKTVFSTSSACRQNSKFTASIISPTTVVLTIHKSRSTSALSELQQEVRQYELATTTASSTRDGNDDSLHRSQSLPSRLRALTHHATQEAFVGSCEDGLLPGEHEGGEDTAERAESTAVASNSRVSQLEAEIQNTRMTVSTLEKTIHHMKVYIDTLERQLKDEAQNNELLKEELEASKKLCCELHEACSRGDMPSSELSSMHLVNDVASVHRSVQTLQQVEQETEPARLPDQSHGKKTQNWYSNILRQYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLH4</accession>
    <name>A0A914BLH4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stonustoxin-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077143.1">
        <property type="nucleotide sequence ID" value="XM_038221215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLH4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221215.1">
        <property type="protein sequence ID" value="XP_038077143.1"/>
        <property type="gene ID" value="LOC119744990"/>
    </dbReference>
    <dbReference type="GeneID" id="119744990"/>
    <dbReference type="OMA" id="CKEREVY"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052090">
        <property type="entry name" value="Cytolytic_pore-forming_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048997">
        <property type="entry name" value="Stonustoxin-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594:SF14">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21109">
        <property type="entry name" value="Stonustoxin_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stonustoxin-like helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="371" mass="41439" checksum="AFAFF730A4F06775" modified="2023-02-22" version="1">MEGTLELPALGRRMCLGTQYDCRSQKIISPGATLWDQETISKQKKVSEKKSHEVTLVKSHTFNDKFKALEVDESLKASILADLVQPAGSAKFLTDQPPPEGTCRLSVYSKATSVIEELPHNQLGSCKILNLEVITEGKATHVVVGILYGSNTFFVFDKTCGESTEDDCLKSLNALVTNFRSCPEEGEESFAFDPKSASDVECKVHCDLDVEGHHSDYAASELLIEIPDMIKKKAVPVKFFLYPLHKIDSRAARVYRVMSDGLLSRVQEFLEGLERCSTRVSEMAADPLCVDFPQFADKFSFFKRMLGDFKTRFQRDFAHEFPLIQGGSKGESDLKEMLQNAATGTPFKLAELDAWLKSKRKELSAGKRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMJ3</accession>
    <name>A0A914BMJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Golgi apparatus protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076966.1">
        <property type="nucleotide sequence ID" value="XM_038221038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221038.1">
        <property type="protein sequence ID" value="XP_038076966.1"/>
        <property type="gene ID" value="LOC119744858"/>
    </dbReference>
    <dbReference type="GeneID" id="119744858"/>
    <dbReference type="OMA" id="MMECLIE"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036884642" description="Golgi apparatus protein 1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="480"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="544"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="732"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="861"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1249" mass="140681" checksum="7F47004AD97EDFF1" modified="2023-02-22" version="1">MASDLRVLLVTYTTLCLFSSICAVFGQQDGVRNDPGAGQIPAAAGWQQTKRDVAPVAGGQGQGPLGGIAAGVGNGAQPQYQQQQKLRINPGQGLGAGQRAFQKPAPGQFDPNQKFDQGNQRPNVGLPGQGPGAGPGGMGGQGQWAPKPVGQQPQGQWQGGQQPQGKPKLGPNRPMRISESPACHDDVANLCGKNALRNNFSILECLQNAGEKNTRAGKKDGGELSDVCNQFLWSYKYNLTRDVRFDSAAFEVCKPDLKKLPECAAIEKGQGLLLPCLYEVAENITTVQCRQYINRMKAITFSDYRLIKDFYTQCQSDVDKLGCGIVYKKGEETALPHKQGATINCLEKKIEELGETCKKQILRVAELTAEDYHTDRALFFACRDDRERFCEAETAGQGAIYNCLLKHKFKEDMSENCRNKLTTRQKVASVDYKANYRLIRKCKEDMKKTKCAKLRDSQGREFRLSKLLICLEEAKHNDVKLSGDCVAELEETRKSLMEDFMVNPEVITQCKKEMANQCSGLQRGGKTLHCLMKLTQGNPKDPKKLSDNCETALMQLVKTADAGANYRIDKALHKACKPVRDKICKEVEAGDAKVLSCLMEHIYDPEMTKECETELLLLQYFVSRDFKLDPLLYKNCKRDVQDLCFTEDFENSNLPEGVVFACLHRHLHPDDREMTLQPGCQAQVHRLLRQRAVSVHLNPQIEANCRSDIGQYCADKTGKGEELSCLQEHHKELSDDCKSKIGGFTEEEAEDIKMNRKLMAACAPMIKQFCKDFLSKKVDEGAALQCLIDHKNDDEMNEKCQAGIEHFQLIQLQDYRFNFKFKESCRKDVIAFCKTSKDKSSIVNCLSSKVRDDTLKDNPQNISEECRKQLKAELLQRSEDIKLDPELFQGCEDDVKKLCSNLKAGKARILECLRDHRKELGEKCHLKLFNRVKEQAQNVKTDFAFMHSCQRMIKQFCPGTAPDSLFKCLKAHKNEPSFDPNCKAVLTKRSIQKKEDFRLNPRMQKACRRDMPKFCNDILDKSKTKEYQEKSMEGEMLLCLKTKFVVKQLSPDCENYVKDTIQEASLDIRMDPILYRVCKDTARKLCGEQMESPGQGQVEECLKSKLHEGKVHDIKCRMQVIRLLQEGRADIHVDTLLYKACALDIKHFCVGIPQGEGRQMSCILEALEDTTIKLHPDCRRMLAERKETWSYAVKESPPGSLSDLAAMVNASEARGYFLTVLLVIIGVLFFGGLCCGRATKRIRAELKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQC9</accession>
    <name>A0A914BQC9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078165.1">
        <property type="nucleotide sequence ID" value="XM_038222237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222237.1">
        <property type="protein sequence ID" value="XP_038078165.1"/>
        <property type="gene ID" value="LOC119745698"/>
    </dbReference>
    <dbReference type="GeneID" id="119745698"/>
    <dbReference type="CTD" id="54934"/>
    <dbReference type="OMA" id="DKRESLC"/>
    <dbReference type="OrthoDB" id="677315at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="448" mass="50761" checksum="C7C571848EAF4CD6" modified="2023-02-22" version="1">MHKSKTGHSRRHRSDGLFCNYAHRICMQDRLDGYEYCLNHILEDKNAPYKHCTFVSNKGGRRCMQPAHKADKRDGYCREHAQKVAVLRHKASLKPFPRNSPREILESLDRYQQDTDKMAPEAQVEAQPSIAAKILDCASESESDEDPMQVDQAWRGTTDSDAESVDSEQEDLLKHAGVYTPEEVALITREKLIRLQSLYINQFKRLQHLMKEKRRQFLVASKQEKETIGSGLGSFTTPKEKRKILRLQAMRSYHHRHGREALLHKRSKHRRIKATPNYMGPQRVSLPAQCKHSSGEKQCGNPALPITGFCMEHVLEDTHQVLYIPCTRGREACAYAADPLSLESTCPLHTPVAPECYRLANQQLEEEYEQEKNATAAMADHDYLQKPTEATEVTEDDIDVLGLSGDQMHLLGTESVAQDAQETCAPPQTSTAQTQQVPEETPVSYAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTE9</accession>
    <name>A0A914BTE9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078827.1">
        <property type="nucleotide sequence ID" value="XM_038222899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222899.1">
        <property type="protein sequence ID" value="XP_038078827.1"/>
        <property type="gene ID" value="LOC119746106"/>
    </dbReference>
    <dbReference type="GeneID" id="119746106"/>
    <dbReference type="OMA" id="GEMPSIM"/>
    <dbReference type="OrthoDB" id="2101380at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="448" mass="51225" checksum="F7FB9C10CF8F54AD" modified="2023-02-22" version="1">MRRNPDAGFVLHGRRTPIGIDKPKEYLTNSQRTISTRNLSQNTLYQPDSRSSSRFSERSFSSASERLQKRDKSPRRYQRLQDSASESVFDAESLFGSMNGGTAARLERREQSRKPRDSEFSLDFTGLGNSLSKSLNKSVSFSKQLEEYKTNGSKAKAYDDDLEDTFEEELQKLIDDDIKENERFEQDLAGKPKSKHESEWFTEPVHLTKTADYPVFQSLGVDTKTTSPVNRTAGMLGTELAQQKVAHQMLLDDVARQYFPVTLGEMPSIMRTVTPQPPNSVAKKYAQARSMESASRSTSNGTGRVSSAPASKTQPPRTHSSHSSTSSYSNPKVDALCDYNYLRASKPFVEETVTASPYQYELAQLKMERLRLEEQRLLESKRQEELERIRGPTPKWYELKSPQFTYELHKNNKLLQSKKDWQNLMDYREQLTRSSQDFAKTDLGGYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YX95</accession>
    <name>A0A913YX95_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine/serine-rich protein PNISR</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044158.1">
        <property type="nucleotide sequence ID" value="XM_038188230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YX95"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188230.1">
        <property type="protein sequence ID" value="XP_038044158.1"/>
        <property type="gene ID" value="LOC119718811"/>
    </dbReference>
    <dbReference type="GeneID" id="119718811"/>
    <dbReference type="OMA" id="QFNGKRP"/>
    <dbReference type="OrthoDB" id="10065820at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031937">
        <property type="entry name" value="PNISR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31518">
        <property type="entry name" value="ARGININE/SERINE-RICH PROTEIN PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15996">
        <property type="entry name" value="PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="109490" checksum="D46F0FBA97A44D3D" modified="2023-02-22" version="1">MWPAHGGQWGAQAQQHYLANEGTDWAALAQEWIRQRLAVDALAQEAREQEQHHHHHHPPPPLPQDVPPPLPDQPPPPLPGNHQEMPHPPHKDNRDPHGVKQWHQDDLPMPPQHGGFFNPNVWEPINTNMPPPGHPHHPDTQLMHAPPPMQVRPHLPPPPHPLPPHPPPPLHPSMPPQHKPPPQLQPPPLDDKPQVQTFDYDHGNQGNQGSHGNGQVAPQTFEHNHGLGVHGIKSELSHSDSPHRHYEFDEFDNQHPPREKMKDEHEQDEQRYHDYHPPPTMQHHEGMYPQDEHAFAPNQDFYYQQQPPSDWSHQGLHPDPHQPRPDMGVGVPPHVDQMLRMDRHGNIIQDRHSHRSFHRHAAEEPEALAGTAELDAIKRKLLPAWIREGLDSMEREKQKKIEKERQEKEKKERLAARRKAEQEVENEIRLAQGLPPKSKYDDSDEESEHSSKKSEESDDEAKPKEGSSSQTGEDEEEGEAEPEPPKTEEEKRAEMMIKVKQLMVETLLSVTNEEMRSVAEEVYKRAKFKAKQAQSKILSVSSSSALASISKLGGLTSYGTDSDDSGSEEEEDKEEVDSDEELHICIREKTRAWSMRKREEEEKSEEEEGDEEDKKSDVKQEVASPVREDAKQGKESKLSPAADSKPSVTAKTSDTVKEKKRKRRRSSSSSGSDSGSSSSSSDSSSYSSSTSSTSRSRSRSRSKERHRHRNRSRSRSKSRERKRSRSRERQRKERSPTPERKRHRSRERERRRSRDRDRSRSRSSGREKSRRRSEHYESESKRRESHRSSHRSPTPKSSKKHKSSSSRRKREDSEDDMRDRDSSSSQSTSKSSSKRKKRSKTSGQDKIKREKSDHSRLHENSKSRDSEKRSRDKKERRKRSRSRSPEHKSSRSRREKSRSRSSERKSDRRKRKRERSERSESREGSLERSHKSSSGKRSGREHRNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY52</accession>
    <name>A0A913YY52_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044297.1">
        <property type="nucleotide sequence ID" value="XM_038188369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YY52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188369.1">
        <property type="protein sequence ID" value="XP_038044297.1"/>
        <property type="gene ID" value="LOC119719012"/>
    </dbReference>
    <dbReference type="GeneID" id="119719012"/>
    <dbReference type="OMA" id="WFLLECK"/>
    <dbReference type="OrthoDB" id="8958829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="342" mass="38532" checksum="EFF28B21A4FB7BC4" modified="2023-02-22" version="1">MTQTPNQHRTAHLISDTPPQLTPQTTYAVTPGLGQSPNMEGAHRQYPHLVPPSEGVSPLRLAGLDPLHTAAEQRGQGAPRMLTTHQVKSVPTFSGKERHGPRLEDWIRDMRFLLGCKGTAPGILQFHEAVRHTGGKARDVLLNLESRTPEGLDAEKAFVELLEEYGEDKSALSPVAKFYARVQRGNETPMEFAIGLESTLREVEETRRRRGQKSEEESRDKMLATQFMVGLKNLHYKQRLAPMQPRFMAFRDVRRELHIIEEEERQAADLRRQQTSFSMSEVAQSLPQVKALGKDVKGPAQPVKEVVPVPLGPNDPNTPIIQQLMTQQLEEMKGCIVVRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZU8</accession>
    <name>A0A913YZU8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045098.1">
        <property type="nucleotide sequence ID" value="XM_038189170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189170.1">
        <property type="protein sequence ID" value="XP_038045098.1"/>
        <property type="gene ID" value="LOC119719672"/>
    </dbReference>
    <dbReference type="GeneID" id="119719672"/>
    <dbReference type="OMA" id="LAYVICI"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="38259" checksum="87FADAA5236516E0" modified="2023-02-22" version="1">MENSSKDIGDAPFATEEPFKVYRCYYERQIFASVLILTSIFGFVGNVMVLITVSLSRKLRTVTNVFVVTLSISDLISCVFLPWQVVAVLSEDGWPLPQAYWICQLTSVMLTIGNNCTINMLALIAVNRWIGVTKSRATTCRVYTCRNIACMVAFSVIIPIFVSVILPLIGIGEMGYEPLYSSCSWVKDNPYSFVQNIVIGVLHFPIQFTVICACYVSIFRYVLKSSRRVAGHDIPSVSGVISGAERAMRKRFWKRQIAVTKNLVYIVLAYIICLLPFSVSVIPLGYDWSIRMTPYAAAIMNFNTFLNPIIYATSHPDFKETFGCMVRCKCKDIPRQACPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z068</accession>
    <name>A0A913Z068_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045218.1">
        <property type="nucleotide sequence ID" value="XM_038189290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z068"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189290.1">
        <property type="protein sequence ID" value="XP_038045218.1"/>
        <property type="gene ID" value="LOC119719798"/>
    </dbReference>
    <dbReference type="GeneID" id="119719798"/>
    <dbReference type="OMA" id="GSINAHP"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="38256" checksum="8FEBA781EADEFD13" modified="2023-02-22" version="1">MENSTDIPPFEFSDMIQRTIVASLILIISLVGIIGNSLVILAVLLSKKLRTTTNAFVVNLSIADLLTCLVIPWDAVALLGKDGLPVGEWICSIVAAVIFTTVGCSICTLASIATNRLLLITRPTATYRRIYTPKKIAVWLVVIWLVPLLTTTIPPLLNVGALGFNQQFHFCGSIHTHPNYNAFNLIISAVLYPIPCFVIVVSYSLIWIHLHRQAKKLTKRPVSSSPISVSAIANNQDAIPMDQLPVPAATSNANRSPGTSRQTEVTKNMLYVVCGFGLCTTPYSVNLFADDNSPLIPYTTVIVLLNSCINPLIYATKHRDFKTVFGCILRRRWVLIPNPSNFLKALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1D5</accession>
    <name>A0A913Z1D5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045703.1">
        <property type="nucleotide sequence ID" value="XM_038189775.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045704.1">
        <property type="nucleotide sequence ID" value="XM_038189776.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045705.1">
        <property type="nucleotide sequence ID" value="XM_038189777.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045706.1">
        <property type="nucleotide sequence ID" value="XM_038189778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1D5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189775.1">
        <property type="protein sequence ID" value="XP_038045703.1"/>
        <property type="gene ID" value="LOC119720195"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189776.1">
        <property type="protein sequence ID" value="XP_038045704.1"/>
        <property type="gene ID" value="LOC119720195"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189777.1">
        <property type="protein sequence ID" value="XP_038045705.1"/>
        <property type="gene ID" value="LOC119720195"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189778.1">
        <property type="protein sequence ID" value="XP_038045706.1"/>
        <property type="gene ID" value="LOC119720195"/>
    </dbReference>
    <dbReference type="GeneID" id="119720195"/>
    <dbReference type="OMA" id="TARWYYW"/>
    <dbReference type="OrthoDB" id="9986409at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="59687" checksum="98AF582C2A38B1B9" modified="2023-02-22" version="1">MSSTDSFVEEEPKMEKIDTRPFLQRRHDVVAWCLGVLFIIAVVGGMFGFGALRGWDANSGWTHNESLTSEERFLPEPFEPEPGVPGRYGDDAAARWYYWKLPPNQVTEWSRTAVWLCYSCHQMLMWGCIFYGQKQKLVWQSNTAPRYSGKLETFNYVALIINAVFHLLHLGQTHWTYDATAQDVSVASSQSSVIMLIVLVLVLEYRDRGLAFGWPTVRNTDRVSRFLLLPKGTVNLLRKYHGYAFAWAAIYTFWYHPMENTWGHAMGFAHTFMIMLQGSLIYTKMHLNRYWRLALESWVILHASVVASQTGGPDLNGTLLWPMFCFGFLWLFTMTQVYGLPFWKKLPSWVRPTPFVIYLAATIGVYSTLPDRQGRYWIRLNEIIRIPGIEYLAVLFSWVLIEFLLFIERKAQANTRPEPLSPAWEALYLMFILLIYVLMITLSSLVQILDLQMSLILLMVILVFVFIVGVSVSSMLLKQCFRRPAGKPAVAPAKGQNDVGETKYGTNEKESGIENVGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z238</accession>
    <name>A0A913Z238_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PLAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045888.1">
        <property type="nucleotide sequence ID" value="XM_038189960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z238"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189960.1">
        <property type="protein sequence ID" value="XP_038045888.1"/>
        <property type="gene ID" value="LOC119720319"/>
    </dbReference>
    <dbReference type="GeneID" id="119720319"/>
    <dbReference type="OMA" id="KPCEPRW"/>
    <dbReference type="OrthoDB" id="10062690at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLAC" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1158" mass="126288" checksum="80C41C20323EBA86" modified="2023-02-22" version="1">MSSAGFERKQEMSPAASGGAKEDAECAGCSRESTDREMTGSATLCRRSPAVGRGLPRLILQWIVLLSHMYSTEALSELRHQLTDTSVNTTSEGSGSQWTEYGSWTACSSSCGYGIQYQNRTCSNLRNGFIDARFCVGSDRRYRICKTDVAQPCQSYMGFRAQMCSEYTEFGVQWKPYLSPSVGPCQVSCYATDETRPVFRILDQWLPNGTPCASYSGCDWWNRAGRSQGICLQGQCSDVGCDGIVNSTKVLDACGVCGGDRAGCRVVSGKFSEIQQDVYTEVVEIPAGAFNIRVYEMEKTRNHLAIKDETGTPVLNSIFEISSPGRYEVAGTTAIYKRCGISRYSPGHYEEISIPGTTSAKIIILMVYTRKYSQANIAYRYSLSLPSPKTLSTSATLTTATTSEIPDVITDLGTTLRHDGEDSTGSPRVGTGNQDMHNVVAVKTLSYRDDEVQGTDEVQGSDEQLPSFPQEDSTVANSGRSATPTAQQNTSAEFKEPTIVGKTESYLEIQNVSQEFQQTVDRTVSGESHVNFLPWSQNSSLHQGKPSVLDNPVGVFSETQERVLWELDGDPEREEDILPVLETSGYLDDNQGETTLEPTSGYPSSNSRLPENSSQVISDTAESHFPLESEEQASSTVASTSPSSSPTSGQMRSFENDLFGDDDLLYITQQDSRTSEPPSVATSIPPTQTGRTVTAEEPEDSQDFPWKYVPGIPDSSELLFGEVPQIMELINPSMESQEPALQPSAAASTAAIVSRGDIPEEERTVKQRYLWARTGVAPCSATCTRGMSRTYAYCTLNGEQVPDNLCDPASKPEVVERECGGKTCETRWAVGSWSQCTVSCGTGAVYRTVHCWLMIAPGLDTSISNSYCSQSNVPESVRPCTLSPCGPQWQTSDWSECSVQCGEGAQTREVRCSVEGATCNPSIKPAATKRCLLQACPSQWTTSQWTQCQGPCTVQNRRVDCVNPRGIIVTDKNCAADSKPLSHRLCGEACPAQWVAQGYGPCLGECGSTTRQRRVVCAATSAVSGHMQVLVDSVCSASPKPSSEMSCELVSCQQQRRVTRRRRQTPQWLTTPWSVCSVTCGTGQRTREITCNRRRNQPRMECNESKKPIGTESCAMGECPAVNPTCSDSPAADCNLIRRANLCRYDSYKRSCCLSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3J7</accession>
    <name>A0A913Z3J7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease</fullName>
            <ecNumber evidence="14">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038045586.1">
        <property type="nucleotide sequence ID" value="XM_038189658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3J7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189658.1">
        <property type="protein sequence ID" value="XP_038045586.1"/>
        <property type="gene ID" value="LOC119720111"/>
    </dbReference>
    <dbReference type="GeneID" id="119720111"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000002">
        <property type="entry name" value="Endonuclease G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="17">
        <location>
            <begin position="86"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="16">
        <location>
            <begin position="87"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="306" mass="34582" checksum="64CB48A6863AFF95" modified="2023-02-22" version="1">MMAPSIWPVVSAISLGVGGVFGSLYERSKQHAANNLTLNPGKSNSGWTPFTQAAAAKQQYPSQPPSPNRSGEIMKFGFPDYGQIQMHDNYVISYDRRMRNAKWVFECLTRDEVKYNDAIDRTNCQFEVDQSVHPFFRSTNEDYRGSGYDRGHLAAAGNHRRSDGVMQQTFLLSNVSPQVGDGFNRGIWNNLEKYVRGLTKVYTRVYVCTGPLYLPHWESNRRQYVKYEVIGTNSVAVPTHFFKVVLGETKNQSYDLRAFVVPNKATSDDTPLKNFLVPIDVIERAAGILLFERLPKSLLRSVNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3K1</accession>
    <name>A0A913Z3K1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038045285.1">
        <property type="nucleotide sequence ID" value="XM_038189357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3K1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189357.1">
        <property type="protein sequence ID" value="XP_038045285.1"/>
        <property type="gene ID" value="LOC119719890"/>
    </dbReference>
    <dbReference type="GeneID" id="119719890"/>
    <dbReference type="OMA" id="RSKNWQQ"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="79"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="282"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="435" mass="50146" checksum="374E80EA6A4832CE" modified="2023-02-22" version="1">MAENDVEQELLDYEEEEHDATQEAGGDATTQVVAKKDVKGTYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVSGQIGVLVMCHTRELAYQIKKEYDRFSKYMKDMQDKVAVFFGGLSIQKDMQRLKTDPPHIVVGTPGRLLALVRNKSLNLKNVKHFILDECDKMLEQLDMRKDVQEIFRSTPHEKQVMMFSATLSKEIRPVCKKFMQDPMEVYVDDETKLTLHGLMQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFIKSVQRCMALCLLLVEQNFPAISIHRAMQQETRLQNYKLFKDFEKRILVSTNLFGRGMDIERVNIVFNYDMPENSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNITELPEEIDMASYIEPDRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4P5</accession>
    <name>A0A913Z4P5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045976.1">
        <property type="nucleotide sequence ID" value="XM_038190048.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190048.1">
        <property type="protein sequence ID" value="XP_038045976.1"/>
        <property type="gene ID" value="LOC119720385"/>
    </dbReference>
    <dbReference type="GeneID" id="119720385"/>
    <dbReference type="OMA" id="VRTIILF"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF958">
        <property type="entry name" value="COLLAGEN ALPHA-1(I) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="6">
        <location>
            <begin position="1499"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1380"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1432"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1442"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1478"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1491"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1719" mass="175020" checksum="A6C88877B20DBDDB" modified="2023-02-22" version="1">MLTSNSGDVKSVLPSLLRFTMRAEALALFVLCLVSSGDVLHGILDAALGVLVTENDGGREVVIGRCRVELGTGRCGLGTGDNKSLTGRSFRRGLLVADAAELPQSLPPDTVDLLRELREGGKIPGVKETEDYDAACLVYWFRKPTEVTAPAVDYFGPRFPKGFSIMFKIRFATERTENLLTVVDDSGNIQLQVRLGPNMCEIQLRTNTLVSYRFFSEKFGDNQWHNIGLAVGNKQKKITGYMDCNEISSFPLRKKFDLKSNGRMIIAGTILPTETPYLGKIQTMYYSAGFQAASDCTTYFQCENQIEVPAATTPAPSTVSLEPTWPDWLIPSIKPTTEAPEPPIPEPTTREPTTPESIPPAPVTPAPQPEPMTVAPVTTQPPKIVPPTTKPFLVPATIRTTSQTFMVGTKHPILDTGVPGLPPGFIDYLLRHDDEQTVVILLEELEFLMPTTYGDPGRPGEPGPEGVPGPPGERGPRGEKGIKGLPPVPLIKSPYVLSTIATDGSRPSGLPWSKRPPGPPGRKGDEGPPGPPGALGPKGAIGPRGPQGPRGSRGKRGGRGRQGPRGEMGDPGEKGYGGFKGTAAQPGSPGVIGQPGFMGPMGAMGEPGLRGNPGLPGVPGFPGYMGLQGEDGEPGEVGEDGDPGPPGPLGDKGEPGLPGPPGLPGPNATGIGPPGLNGSVGLPGEPGAPGMVGMPGPQGMQGFRGQKGRNGTQGVRGLRGSPGPEGIEGDRGDRGFKGMKGRQGIEGLLGEPGFEGYQGDRGEKGGIGRVGPPGQRGEPGLDGDPGIHGEVGQKGDTGPDGFPGYPGFRGDRGQPGIDGIPGEMGEEGEPGPLGPPGNNGTEVKGPQGQPGPIGAPGPPGHPGYDGSPGPRGPPGLPGEPGFDGYSGRNGTKGRTGRAGTPGYPGGAGMPGGEGQKGEPGNPGLAGAPGTSGERGSQGIKGEPGEPGLPGDNALDGYAGDDGLIGIEGPKGLQGEPGMPGPNGPAGVAGDPGKRGIPGDRGPKGDKGEQGKRGLRGEVGRPGASGARGPKGPKGDFGGGGGLGILGRGGRRGRYGGRGTYGPRGEQGEKGEQGPKGEESPMGERGIAGAPGPQGEIGIPGARGPVGRKGIPGPQGPQYGGLGEKGRKGIEGVVGVPGPQGAPGEMGPPGVKGSKGDPGIDGDIGPPGEPGPDGPTGPLGLSGRNGSAGLDGLPGEKGPKGVDGVYGTAGADGIVGLRGIPGEKGEMGALGPPAPPGFPGYFGIMGPKGRVGLRGRQNRRGFKGAKGDRGVKGPKGSKGKKGSRGPEGREGYKGALGEPGYIDDGEDGIDGIKGPVGMKGEKGDRGLQGPRGPLGRAGYSVTGASGPYGPPGERGPKGPKGELGAPGIPAQPGEELVQGPLGPPGPRGPPGPPGKPGKIKGEKGDMGPKGEAPQGPKGQKGQKGPPNDPPVRGPKGPKGNPTPGHPGNPGPPGSPGPGPGSIGPQGHKGVQGPKGIRGPPGPPGPPGPPAGTAPLPTTIPRITPSTLTPTPSVPDIRKRTGTESDPAVNCKDLKSDFPDYPDGQYWLDPNEGSAGDKFQAYCDLTGGGRTCVSPITQTLETKAWDISEAGWFSTWPEGFTITYQASTVQLRFLHLRSKKATQEITYTCQRGVAYFHQKGNHYDKAAQFKAYNDETITHESPTLQVSQDDCQSAPKKQKTTVMELSTKVVEQLPITDINPQGYNKNKGQAFGLEIGAVCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5B0</accession>
    <name>A0A913Z5B0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046939.1">
        <property type="nucleotide sequence ID" value="XM_038191011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5B0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191011.1">
        <property type="protein sequence ID" value="XP_038046939.1"/>
        <property type="gene ID" value="LOC119721120"/>
    </dbReference>
    <dbReference type="GeneID" id="119721120"/>
    <dbReference type="OMA" id="MHKDCIP"/>
    <dbReference type="OrthoDB" id="10043687at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="8">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="637"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="700" mass="78983" checksum="9B023D3F39FE79F3" modified="2023-02-22" version="1">MVKKKVPPTVFSSATQHKKRKKKYSKGFLKSPNRAARVQKAVHQVVHENIPIKRAARQNSLSYGFLHRRISGDVDVESRNGPPTMFSVEEERSLSRWLSEMAKRGMGLSPGEFLDFVEEIIKKEKSCRNFKSSRPSYTWYYSFMARNSDVVERRKEASLESSRIKVTQSKLDRWFDSYYQFVSSLNLLDKPHRIWNADETGFQMGSKSGHVIGPTTSEYTGSLPHLTGGSTKQRLTVMYCGNAEGELMPPFFVFPKPRPTAYDPLVGSTRGSAVTYTKKGWMNGDTFSKFLDHFDRNAGPERPVILLIDSASCHIDVNTFDYAVAHGIEIYRIVPNATHLMQPMDVGIFGPLKRQWNLTVKKNTREQPGDPINKATFPAKLHETVLAFYKPLTVMNSFKSSGIYPINREAISNEKLKPSLTFKSKTPQDEPSTSVPSQRADDAFQVFRSVLDEATVTEYEKRMSLAGGDDDAESLPLSPRFRTYKQLKMKTGIPRELPKVSAVQQATEYNIPCGLSMLVAAVDHVTSEECATPENTVTSSQPCSQATISNTLEDALTFPQAVPTVSRSRRLLDSLPDNLTSPDCLRRMALHQLEKVRHKAKMEHKAKQRYLQKKKKENKSTSTGLGEYPQDHGQGAETLCPVCNVSYEANVRKGDNLMWIQCDECLEWMHQKCIPSSLAYDQETVVEDTNAKFVCHKCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5E0</accession>
    <name>A0A913Z5E0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045985.1">
        <property type="nucleotide sequence ID" value="XM_038190057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5E0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190057.1">
        <property type="protein sequence ID" value="XP_038045985.1"/>
        <property type="gene ID" value="LOC119720392"/>
    </dbReference>
    <dbReference type="GeneID" id="119720392"/>
    <dbReference type="OMA" id="HNCTHAS"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="76"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="183"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="209"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="289" mass="31272" checksum="C4441940B4DF3140" modified="2023-02-22" version="1">ISESEIARLFTTGTRVVRGPDWGYGNQDGNPPGEGSVDSELSSGWITVQWDAGHRAGYRVGAGGKYDLKLVEDAPIRLVDGDDKLNGRVEINHDGIWGTVCDVNWDIQDARVVCRQLGNFLEAVEIKTGSFYGESERPIVMNRVACRGTESRLADCPFVCTSSRPCNTSQVAGVICRPKLNTVRLVGDGSNAASGRVEIYRDATWGTVCDNDWDTDDVQVVCRQLGFSGAVEAKSGAHFGQGEGPIHMERVTCDGSESQLADCPSHCWETPACSHAQDAGAICRQDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8P9</accession>
    <name>A0A913Z8P9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038048029.1">
        <property type="nucleotide sequence ID" value="XM_038192101.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048030.1">
        <property type="nucleotide sequence ID" value="XM_038192102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192101.1">
        <property type="protein sequence ID" value="XP_038048029.1"/>
        <property type="gene ID" value="LOC119722083"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192102.1">
        <property type="protein sequence ID" value="XP_038048030.1"/>
        <property type="gene ID" value="LOC119722083"/>
    </dbReference>
    <dbReference type="GeneID" id="119722083"/>
    <dbReference type="OMA" id="VKSAMCP"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="795"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125246" checksum="66C1A0F5F4673CA1" modified="2023-02-22" version="1">MSTSPRHILSPGVPDYQGKRASLPYAPNKEELVELRFTRQLSTSHPKLPSNSSNSVDNLVPVERPRSNSLIRIADIKRNLSASNLAALSDSNLSIKKALPLRSYDAPNTSGSAAKRHFVQLVKQYYYQLTEGCGNEECQNRFCRSCKESKRVYCDVAAIISIRLASSQRRYLCQVDNYADRPLPQEVFQPPNGEAKPFLHTLFSTTPFKSLFTTQPPQAEPKRKLSPAVANSHPPNHSTKFPAPAQTGSLINAKPPTGKKGPSPLRKVSSRKGKSKSETGIRGKDGRLNGISDQAGLDDFGSSDSNFSEDHQRLSTAAARDDLRLSHQHSAPNLASGESDATHLLSDDFGSDENFLIHHGRSRSTPVGSYGNLSISSAMSFGSGPPGSLPSMNSSPARLLSSQEALDETDDLRQFERSVSLEMSWDGVGEFSLTHLTLPMLEGAIETYKSSEDPSFLINTIRTVFTSSEALNASFRYEDGNLASIDLSAVRQAYALLWTLTPLDVFLSTMTNALEILLMSLDTTVIQADQINQILILLENPLLETRELLRIFCHVITKLPANTHQALVRALSSYDRKHFQRLLQLIKTYLGSVLRPNHRVHENIICIAKVLSVLHEASTLAESEGKTRHNPEQLATMKDFYSDQLSRNMDYMGEFHKWKLRAQRKEKATASVSHSSTSDSGFSSTSSSSGLSEEQGAHSRAVSGSEMESLLDFPFLLDPSSKVHILHLDAVMQMRQEYQAAILHQARVYQAQKYLLNPNKNALKDSIKAAMCPFLVLEVRRFSLIRDTLAQMRLKRRDLKKPLKIKYVGGGEQGLDMGGLQKEFFQLITEAVFDPKYAMFTVLEESRTLWINGGSLESGDEFELVGSLLGLAIYNGIILDVHFPTAIYKKLHGEVMDIEDLMEIQPSLGRGLKELLAYQEEEEDVENVFCQTFQISYTMMGELVTVDLLPNGSQIAVTNENREEYVRLYIQHILVDSVATQFEAFAHGFHTVCGGSALRLFQAAETEMLVCGSPELDFMALEASATYEDGYSRQHVTIKAFWTIVHSLREEQKRKLLHFITGSDKVPLKGLSSLPIVIQRNGPESDRLPTAMTCFNRLLLPAYNTLEILSQKLLVAIENSKGFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9H5</accession>
    <name>A0A913Z9H5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048289.1">
        <property type="nucleotide sequence ID" value="XM_038192361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9H5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192361.1">
        <property type="protein sequence ID" value="XP_038048289.1"/>
        <property type="gene ID" value="LOC119722312"/>
    </dbReference>
    <dbReference type="GeneID" id="119722312"/>
    <dbReference type="OMA" id="EMADCNM"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001083">
        <property type="entry name" value="Chromosome transmission fidelity factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="418"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="908"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115678" checksum="51192D1AAB687DC8" modified="2023-02-22" version="1">MEEDFEDRYADELEAMREMEMDFEASQRSQSQNRTALSQTGKQSHAPLTNGSQNLSITKSTATTSGLSQPKSQSDPIAALNTNGKSSSAFSGLPNGFSREPEVDGLERKAKKRDIEEMFGPLSDSEDELVIDAALPTIAPTAKRPRKLFPDASKTTDRATTSPPPSPTPEEKALAKIMLHRQQSASLAQQPAEPTRALSANSGQDTAWPAGYRRLQILHREPLGLSARITGQDGRRVYLRMKDVVGVEGKMKNKSIFKQTPGHPLRLLAVPVEMMQDDLESERHMRLVKQAQTISASINGGLSKKLGTSAGDEADDEMEDDDDTGKEAATKEKSSALWVDQYAPRRYTDLLSDDGINRNLLFWLKLWDHLVFGKEKKQRKKPKLEQQQKQAEAKNLKFKNKFQQEEQQEELDENNRPVHKIALLCGPPGLGKTTLAHIIAGHAGYNVVEMNASDDRSVEVFRNKLESSTQMQSVLVMDKRPNCLVIDEIDGAPTPAINCLLAFIKGASDNKTPTEAGTATAKKTKSKNLLRPIICICNDPYVPALRLLRQQAFVTHFPPTLSTRLAARLNEIARNNALRTDMTALMALCGKADNDIRSCLNTLQFIHGQGRVLSLALVQSLSVGQKDRHKGFFSIWQDIFKLPQPKRKQYANPHDVAAGKAKIATAADGTLGLDTSNPTSTTARFYNVVQLAQGAGDYDKLMQGIFENYLEMKFKDPRLEALNLASDWLIFHDRLGSVVARSQNYTFYRYLPYVPVVFHLLFASSSQPRLKYPNTAYENSVKQTRTQNLLSTVLSEVSPSTACFLDPRMAVTQILPLLLIILQPTFRPVNTQLFNAQEKRHMKELINTMIAYNLTYNQERSAEGQYNYVLDPNLDSVVRFSSTPPTKQMTYAAKQLIAREITLEKMRRSEAAVGGKNRDMKKGTKPSAPVKKAGPAAQSKVPRHLEKLQPKKVQDEPEKPTRDFFGRIIKKKSPGPKLADTATSTDGVDANNDPGSSQSSKAEARREQQEQLAGKLWYKFNQGFTNAVRKTVRIQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCH8</accession>
    <name>A0A913ZCH8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049244.1">
        <property type="nucleotide sequence ID" value="XM_038193316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193316.1">
        <property type="protein sequence ID" value="XP_038049244.1"/>
        <property type="gene ID" value="LOC119722911"/>
    </dbReference>
    <dbReference type="GeneID" id="119722911"/>
    <dbReference type="OMA" id="HPFHVIA"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="129"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="35092" checksum="DB13A06A9338BEAF" modified="2023-02-22" version="1">MAHDQQSKDPWVQLALNVGLTAVAHPMGYVKTLIQIGYEPLPPRPGRNVFFRKTLLLPGVAAYSRHIYKVDGFLGLYRGFVPRLCSTITGSAVATKVAEKLDELFPVTDQKDLEAQKGKAKGTAQVSNATFVLETCKMTVSHSCAVIVTHPFHVIAVRSMVQFIGRESKYSGWLQPYGEVYSDSGIKGFFVGLVPRLLQDVMTLWLARTLFQIFNNLLLSDKMVNINELRSYAYAITGFLAGIVTYPLGLVSNMMAVNDSGLVAGSPPFMPKYSRWTDCWRDLSHKGLLKRGSSILFRRYEPGKMVVEPIPATPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCN0</accession>
    <name>A0A913ZCN0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin-13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049528.1">
        <property type="nucleotide sequence ID" value="XM_038193600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCN0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193600.1">
        <property type="protein sequence ID" value="XP_038049528.1"/>
        <property type="gene ID" value="LOC119723088"/>
    </dbReference>
    <dbReference type="GeneID" id="119723088"/>
    <dbReference type="CTD" id="9670"/>
    <dbReference type="OMA" id="KYPAEMA"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112774" checksum="E32293DF1848F75B" modified="2023-02-22" version="1">MVKYLTAQGKICDGRPSSSEVYKGFVTEFPDSGTTALIRQRMASSTQTRSDTSLDVNVENIEKAIHQLYYDPHPGVKNSAQRWLLVAQRSQHAWQFSWTLLSPDKATEVQYFGASALHTKISRYWAEVHPEQYDILRTQLFRQIFAFGTGARIVLTRLCVALSSFALNTMPEVWPDAVKGIIDTFQQTDIPQLDATHRCTALLELLTVLPEEFHTSPLPQARRGTVRHELENGLQHVLPLIKTLLEQQDSPDAVRLQALKCFSSWVQLNVPLPDIDPITEMLFQLLLNHDLFDLCIDSLISVVCQPVAYKYPLSVRKVIKQVLQLQDHLSTAVQDKDMDVVQGICRLAVSLGENNSKILLESEGEDRQHAVEFTNLIIGFTALPGHYPVDETISNIPFGFWYILQDDIVSSDQEEFQEYVRVFAPVYMHLVEVMLTKVQYPPDEEYSSWNAEEKEHFRCYRQDIGDTLMYCYTLLREPLLNHLYAILSRIQEQQLPWQQVEACLFAFRSIAEGGDYGDDQCVSDLLRLLSQVNMSHTTLASTALYMLGAYSEWLADTPEALRTVIPVLLTGLNDPELAAPATMSLKDICFECRKEMKPYAETILNASQEVLRRNTIKARESVRLMSIVGFVLSTLSLQEILSYLQLILAPQLQILESAINEQPTPITKSTILLKINMLSNLCSTLDLKRPDRTEQEEESIAAKRAAPAQDEPQPVFLILQQTLPILQNLLSVWISDVGVVEAVCELLRRASRTLLDDLQPMIPQLAELVATIYNALPQSAILDLARQIIILFGDSKDVCSAVGAMFVELCSKTVSLFPARAREQTDVVETFMAVCSILLKKQSRVFVREGCNPAAIFQCGLMAITLPENPTVKSTCNFFMSFIAQSDNLPALGEALTQHGRSLLELVLKAIGGAAPRTVIESLADVLFMLNKHCFSQLTSWLPEMVLSPDLNLPRVTKDQREQFAKTILRNRAHKRQIRDVVSEFSLMCRGLHGTEYAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCY1</accession>
    <name>A0A913ZCY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048901.1">
        <property type="nucleotide sequence ID" value="XM_038192973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192973.1">
        <property type="protein sequence ID" value="XP_038048901.1"/>
        <property type="gene ID" value="LOC119722717"/>
    </dbReference>
    <dbReference type="GeneID" id="119722717"/>
    <dbReference type="OrthoDB" id="2121618at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538">
        <property type="entry name" value="LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="967" mass="107804" checksum="93D9D10C963862E6" modified="2023-02-22" version="1">MTEFPTLCVLNYDRDGAEQQRSTAVGLRLPRPRKPRPRSRTHPPRELERDGAAAEARDREGLEFLARGVQGSGEYGAKTQLNTTPYRYGSSKSSSLQASRDDNQLNPKHSHSSYTTPELPQCIHNGHHRSLSEPPPRASERAHTAPTSAFSLPVLRQGGAGDTSLTVNAELLQDPKWNEYLSAWVSGAQVGSHAFVSFVGAMSLKDRGRYHYMRQFEELPALPCPRFFEHMHRIPAPKSLWKDKKKDLKKPEFWTWKGRTSPKIPKPRPVRKRVQVCNSLQAVQITPPSTVQCLTVDIPTCSQDSEGSLATTPTSDLCTLSDPTSSVGAPSPVRTPEEEKTVRWQVEKPPEQLALPEIEEYSEPSDYGSIRSGMSSPVSVGSQHTVTSGIESLDTEPAFGQSHRRFPLKLHKLENPPRPPTAVDWDKHSYLAGFDDNDSESEEEGDDADRNHGNENAEGAPNVNQKDVTMGPLETSKVDQSSYMYNDHIAALEPVVYESYLPLDDPLEMMRSLTVPGCQQSVVEPYPLEEPLQPDVAGLDRNVIQRSSILTRPELPSPPPPPPPKEPTPPPTPPPPPKEPTPPPKTPTPPPIEKPKKKPSKPKRPPKKEKVKVVKAVKAPVKQPTPTPKPQPMIAPPTSPTPPPPPEPEPVKIPTPEPPKPQKVIELPPLPPVADPEPEVASEVNESVNSNSPEPDDLADEPSEASPATSPTPGTPPPPPLPSSPAERDMSFAQELERQRLAEERHRKAMLMYDKLRAKQPIPTARMEEADNMKEYGWLAQFCILKPEKLRMYHMAFDTVDENHKGWLSCFDTLIALKGITGTQNLTEKEEEYICRILEIADYNILEGSDFRIFSVMAGLSQKLASIDAWVRNLIQKIDLQTLDWKMYRGKELFEWCMDESTNRLSVSRLLIELRAGGVSDLHLDEVRDKFGEDGTLDLIDFLTYLPLFIMTHKSVVCNPLCDVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZES2</accession>
    <name>A0A913ZES2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049556.1">
        <property type="nucleotide sequence ID" value="XM_038193628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZES2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193628.1">
        <property type="protein sequence ID" value="XP_038049556.1"/>
        <property type="gene ID" value="LOC119723103"/>
    </dbReference>
    <dbReference type="GeneID" id="119723103"/>
    <dbReference type="OMA" id="ECTYKME"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="16828" checksum="C143FE850C83BB46" modified="2023-02-22" version="1">MAQVSVSKLSASTQRSSEARGGGPLGGTRPQARYECTYKMEPDKKFMSHRAGNIIEDVLEAELREAKYEPERSQNLCRYLADTIKNRVKELDFDRYKIVAVVTIGSLDQNASSLASQCVWNEKYDTYSEFTFKNGSLYALGVVYGIYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJY9</accession>
    <name>A0A913ZJY9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052103.1">
        <property type="nucleotide sequence ID" value="XM_038196175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196175.1">
        <property type="protein sequence ID" value="XP_038052103.1"/>
        <property type="gene ID" value="LOC119724882"/>
    </dbReference>
    <dbReference type="GeneID" id="119724882"/>
    <dbReference type="OMA" id="HRIINAV"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="4"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="13">
        <location>
            <begin position="891"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1250" mass="142056" checksum="450F6A8D3892CD38" modified="2023-02-22" version="1">MALKPVDDLATLESLDEKAILEELKRRYANDIIYTYIGDILIAINPYKPLSIYSYQTSCSYTNLQYRQALPPHIFAIADKAYSSMKRLGMRQCCVISGESGAGKTESAKYLIGHVISHCSSNKKNLQEKILQVNPLLEAFGNARTVMNDNSSRFGKFLELKFSHDGRIVGATIDQYLLEKSRVVSQGKGERNFHIFYYMFAGLTEQQLLNLLLSPPEKHRIINAVSGQGVYESEEEFLFNQKMYDELQDIMELVGFTQEDIWMIFTILSAIIQIADIDFDLDDETGGSYIVDEYILKVVCNLLGLDVVEMATALVSNVSYTRGEQILTLKTVAQANDGRDALAKALYSKLFTWIVRQVNTLIAPDPHLQGGTEGYEIGILDIYGFESFETNSFEQLCINVTNEQLQFYFNQRIFAWELAEYASEGISHAKIKFQDNQPVLDLFLARPLGLFSILDEESRFPQATDVTFVSKLISNHGKNSNFLKEKKSRGQTKFGINHYAGELWYDASGFLEKNRDTFSANLTESMLHSQNGLLRYLFSASEAELSESKQSGPFAVSQSQKDILLCKPPPKIIHDGTVSLSRAATKKLKKQMKDGKAQSDKGKRRPTLPSIGLHFKRSLTDLMAKILGAEPQFVRCIKPNSQSRNDFYEDRLVQRQLQYTGVLETIKIRRMGFPSRLNFADFIRRYKFIGFPLSASIKANAAACKKILQAGGLSGFEIGKTKVFLKYWHSEKLDTRLDQLVSSVVTCQRYVRGRLGRKFTRSVREKGWKQRGAVAGFLEDVELYNEKILRLMVKMDKHDKERFEAKKRQMLLGELRVKTDERQRLIVEQNERKKVPPPTAPKRYSYGVPVVAATNGVPTERTQIPTRKSKIEEELLEELGYQLPRIDPDAWAKVYFLEKRCRLVDFNIKSAAVIVDGSKFQYPGRLGFGALHNPLRDKQTEKVRGHIGKGVQVEVDKEGNVWATRLGKNEVFVKGCFDPENHCISADVIERMGHLETNVPMKVFDIKEYKIQLALEAKKSDQSEIDKKRLKQLCNVSLSFVKDAVEDVNTPCWISIVVLPALRLDNPKILQDATKILSVYRTAKQIESSEMGRSASRKWAKSNMRRSNFEKENTKKDGRKARLNEMEKAKKMGMEAMYSWENPKDDKGNQPAVTKEMDRLSIVSNDSDTGSSLYQGDEGGYQSSSVRRAVLRSLSVRNAAAFRQRSLKRFQETGAQDIEVPEDPYSVNGGRRVWAKAKQKQREALADEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK12</accession>
    <name>A0A913ZK12_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MKRN2 opposite strand protein-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051376.1">
        <property type="nucleotide sequence ID" value="XM_038195448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK12"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195448.1">
        <property type="protein sequence ID" value="XP_038051376.1"/>
        <property type="gene ID" value="LOC119724406"/>
    </dbReference>
    <dbReference type="GeneID" id="119724406"/>
    <dbReference type="CTD" id="100129480"/>
    <dbReference type="OMA" id="PNMYGMM"/>
    <dbReference type="OrthoDB" id="10065749at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032016">
        <property type="entry name" value="MKRN2OS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053921">
        <property type="entry name" value="MKRN2OS-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963:SF2">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16044">
        <property type="entry name" value="DUF4796_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MKRN2 opposite strand protein-like C-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="227" mass="25229" checksum="B3745F49A829B87C" modified="2023-02-22" version="1">MHCACCAADMATRPPSIKSFAHQCHPVTRLLVFTLPANCPLCGQKVDASSVTSPVAQYPSPFVSSCGVPFSVVIKPTVGDFLQSYGQDDNLHTGITTSKGTVYSYDETGVHRECLGWSQCLTVSLLEEYDEDLRSGWDRRLAGMDTEPEWQKEWYKDDGHNCFDFVVGFLNAIGYRHPHHNQNGPITREDFCRDLIMPVTCRAAGYIGIHRSIARYGFLVEQASKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMM2</accession>
    <name>A0A913ZMM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052340.1">
        <property type="nucleotide sequence ID" value="XM_038196412.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196412.1">
        <property type="protein sequence ID" value="XP_038052340.1"/>
        <property type="gene ID" value="LOC119725047"/>
    </dbReference>
    <dbReference type="GeneID" id="119725047"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036861233" description="HYR domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="4605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="4504"/>
            <end position="4533"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="220"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="396"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="558"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="759"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="931"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1128"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1702"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1899"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2082"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2279"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2465"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2560"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2640"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2724"/>
            <end position="2801"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2802"/>
            <end position="2888"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="2971"/>
            <end position="3052"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3053"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3137"/>
            <end position="3217"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3218"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3302"/>
            <end position="3381"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3382"/>
            <end position="3466"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3467"/>
            <end position="3547"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3548"/>
            <end position="3628"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3706"/>
            <end position="3789"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3790"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="3875"/>
            <end position="3956"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="4035"/>
            <end position="4117"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="4119"/>
            <end position="4200"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="4201"/>
            <end position="4281"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="4442"/>
            <end position="4480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="4451"/>
            <end position="4468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="4470"/>
            <end position="4479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4605" mass="492102" checksum="21ACA6CEEE841C3B" modified="2023-02-22" version="1">[encoded data, 4605 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN58</accession>
    <name>A0A913ZN58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Splicing factor 3A subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Interacts with HTATSF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053172.1">
        <property type="nucleotide sequence ID" value="XM_038197244.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053173.1">
        <property type="nucleotide sequence ID" value="XM_038197245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197244.1">
        <property type="protein sequence ID" value="XP_038053172.1"/>
        <property type="gene ID" value="LOC119725710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197245.1">
        <property type="protein sequence ID" value="XP_038053173.1"/>
        <property type="gene ID" value="LOC119725710"/>
    </dbReference>
    <dbReference type="GeneID" id="119725710"/>
    <dbReference type="CTD" id="8175"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001216">
        <property type="entry name" value="Splicing factor 3A subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="17">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="215"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="296"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="53879" checksum="03A60E00155BDDD6" modified="2023-02-22" version="1">MDFQNRAGGKTGGGGVASESESNRDRRERLRQLALETIDLNKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQSNLARRAAKEAKDAPAQPALLEKAKVDIRKFVKIGRPGYKVTKQRDPNMGQQSLLFQIDYPEIAEGIGPRHRFMSAYEQRVEPPDKKWQYLLFAAEPYETIAFKVPSREVDKSEAKFWTSWNKETKQFFLQFHFKMEPKPMPGPGDGPGPRVRFPPPDDNRLNQGPPRPEMRGPHPRGPPPPEGFRGGPPPRGPPPGGFHGPRGFPPNRPFMRGPDQGPPMRGPDQGPPMRGPDPGPPMEGPPMRGPPPPFSGPPFGGPPMGGPPMGGPPMGGPPMGGPPPPMGGPPMGGPPMGGPPMGGPPEPPTSEGAPTGPPMPPPGMGPPGPPGPPGSERPPMPPIPPPPPPAMFSTPGGNIPPPPVPPPGMPQLPSLMGMKPPPMPPNFPPPPNAMPGGLPLPVPPPPPPAVLLQPQGMEEEDEAEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNS6</accession>
    <name>A0A913ZNS6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052701.1">
        <property type="nucleotide sequence ID" value="XM_038196773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196773.1">
        <property type="protein sequence ID" value="XP_038052701.1"/>
        <property type="gene ID" value="LOC119725365"/>
    </dbReference>
    <dbReference type="GeneID" id="119725365"/>
    <dbReference type="OMA" id="CHTAILN"/>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="27409" checksum="ED8156B30ED462EB" modified="2023-02-22" version="1">MCCSCDAGTAVFCCKYILVVTTCITNFLCGCALLGVGLWLCFEPNVQQYAQASGDLQEYYIAVYVLIGIGGLMMLVGFLGCCGACMENTVLLGMFFTFLLLICVAEVGGGIWCYLNREKLKSIVEEGMLSTVQQAYAEDNSVIMTAVDNMQRQLKCCGATGPSDWQQSAYGTVPDSCCKEEAEGCAQGIAFQAITSLLTINQDGCATALFNMLEDNAVLVAGLAIGIGAVQLLGMLFSLCLCCAIRRADREKSYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNV8</accession>
    <name>A0A913ZNV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053422.1">
        <property type="nucleotide sequence ID" value="XM_038197494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197494.1">
        <property type="protein sequence ID" value="XP_038053422.1"/>
        <property type="gene ID" value="LOC119725900"/>
    </dbReference>
    <dbReference type="GeneID" id="119725900"/>
    <dbReference type="CTD" id="146923"/>
    <dbReference type="OMA" id="THKGNHW"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="395"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="588" mass="65951" checksum="9A142D7F789426B5" modified="2023-02-22" version="1">MAQANDAPVLRLIPDVIQHQPRAIMSLDSRPLQACRLYLASGISTHGISRDVHVNMVDQLQHLEEEQEQLNSSLLALTTHFAQVQFRLKQIVNAPIDDKENLLKDLEEFAFKGCPDVRGSRSQDAQMLEDASEKEHESRITEQREKQMELISQLKSQLDDLEQFAYEEGSGELPQNMILEKQNVIIEELKQKLGLNIEDMDKLTTDDLRQLVDSAIGRIVNPAKVKETVIHQLKNQIGDLERFISFLQGEASTPGLVTPNSCSCPVDAKDDTISEADSEAPDCCVHPKAGKLGSKQSTAERIKKMRESHISSMKKALALLQYMAITQLGCGTDKLKEKKTAKPDASDDYREMLKVLDAAVNHVIMLARQQQESPAEDSDYTSDSSDSPVNRPLDDVTVAVRRELAPALRDLFEHGQFKHSSSSDALITPITACLATHRNTSSQKVHAWDLFVKYYDIKKGKAFAMSPARKLSQAFDIDIVGGTAITAKQTLLAAIDYVSGSHEPLKRSKEAQFKAFVSEALNGQKLAIWCRLISRTTSLIDYHYYPWSYMMKNSFDGALQLLDKLSEIKFRLNVDIAVQQFYNIKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNX9</accession>
    <name>A0A913ZNX9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038053447.1">
        <property type="nucleotide sequence ID" value="XM_038197519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197519.1">
        <property type="protein sequence ID" value="XP_038053447.1"/>
        <property type="gene ID" value="LOC119725908"/>
    </dbReference>
    <dbReference type="GeneID" id="119725908"/>
    <dbReference type="CTD" id="2632"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000014">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="222"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="707" mass="81031" checksum="70150D28E638CE43" modified="2023-02-22" version="1">MPACSKVRGPVRPHHTPFLAMSFETDIPPDLESLCRLDPYLKPHEHEIKRRYGCLQKLLRGIEADQGGLDSFTSGYKYFGLNKTPDGGIVCRQWAPAAKAVYLRGEFNEWRSGEHAFRNIGYGKWELSLPPKDDGSCPIAHNSIVKLQIQSQSGDLLERICPWTSYAVQCQDTMLFDSVWWDPPQPYQFKHPAPKIAGGLMIYEAHVGIASWKGEISSYDNFTDNVLPRIQKQGYNAVQLMAVMEHAYYASFGYQVTSFYAAASRCGNPDGLKRLVDEAHQRGLVVFLDVVHSHAAKNVLDGLNQFDGSNSCFFHDGHRGEHMLWDSRLFNYTSWEVLRFLLSNLRWWVEEYHFDGFRFDGVTSMIYHHHGIGTGFSGGYHEYFGLSTDTDGLTYLTLANHMLHSFYPDIITIAEDVSGMPALCRPVSEGGNGFDYRLAMALPDKWIKLLKEQKDEDWNVSDIVWTLINRRHGEKAVAYAESHDQALVGDKTLAFWLMDKEMYTNMSKLTPLTMVIDRGLALHKMIRLITHALGGEAWLNFIGNEFGHPEWLDFPRPGNNNSFHYARRQWNTVDDPNLRYQHLNNFDRAMNELQQKKQWLKSPQAYISCKHEGDKLIVFERAGLVFIFNFHFTKSFTDYRIGTNVPGEYKILLDSDAEEFGGHCRLDHKTQYFTSPSPWHDRQHSLQVYIPSRVALVLGLVYDTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTM8</accession>
    <name>A0A913ZTM8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054957.1">
        <property type="nucleotide sequence ID" value="XM_038199029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199029.1">
        <property type="protein sequence ID" value="XP_038054957.1"/>
        <property type="gene ID" value="LOC119727165"/>
    </dbReference>
    <dbReference type="GeneID" id="119727165"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="724" mass="84067" checksum="8A1E2D223DB1C909" modified="2023-02-22" version="1">MDIASSPSFEKQDETTGKWQVTKKAEYKKKRAYEELKKEYTAHPEDLPLDKKLELCYLKFQNLEFKEVQDMLGEMEEDNFKIPHLLAETNWKLGLEKEKEMEAETQKCEPTKATPYFEEARKNMYLAIQKGLTNMGGRKILADIALSIARNQFHLVDSQQPEPTRAPVPLESPCIKSYREAVRCGSVVASLELLRLVSPQLKTTTSRSHFLMILAEIDLCCSQDPSVHLHQDVKPLPLEDDQLKDLSTVDCEEMRNHIDNLIQEGSYFTPAWEEYFNMERRFLEERLTNNDKKVELDGREEEADSTQLASKKTRSAGIKCCSQIRPLLDHIIVEFREKQLGIEDQRMKLYFPLICESRDYQNDNERREETTKSLRKVLQDYFEIDMANHYPKLFKNVLEVQPSYDSQNDFLRSLFDVVNNYKHETFNQDKLLKDIDDPVKFFRQCMDKVEEIWIFFSDAMRETRDLKEKVKQLEDDIRRGKYEKADELLEVLSNNEDFVVRIGSTWELLKKMALIRRSIQQQTVDDAESKLVDGEFGFSHDLRRCHLTVELLKTDPGASSTELHEKCRDTCREATNMLALVLSKKKPHGGQSATQQPMPAVTFPFCDLHPGVDRVDQWKGKVKKHLNKELNKMGIPGSVKDNKELLETIMQAQPCTDEENYQFMAVEQFLKQCDEGGAIPDTVSIKPNNQEEKTFQVLDLTRWITDNAEKIAINIDTLKKVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUB1</accession>
    <name>A0A913ZUB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038055167.1">
        <property type="nucleotide sequence ID" value="XM_038199239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199239.1">
        <property type="protein sequence ID" value="XP_038055167.1"/>
        <property type="gene ID" value="LOC119727371"/>
    </dbReference>
    <dbReference type="GeneID" id="119727371"/>
    <dbReference type="OMA" id="YKMQCEE"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="106"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="445" mass="49535" checksum="DFFB05B7459F1DBF" modified="2023-02-22" version="1">MDYKRFLNYYGLHLQPPVIRQIVSATPSGVNKSASAGFPNPTAFPIGSATFDLKDGTQIRFTEEEMNVALQYGKSKGQDDFLDLLYKMQCEEHHPPTASVEAGPSKMSILMSPGAQMALFTFAMVCVSDGIPIIFSTPCFAVMSAPLVDFIHNALCVEVDADGTVPSSLRSVLSKWTPQDANNPQSGIPRILWLNPTCNNPAGVTTSAERRKEIYAIAQEYNLFIVEDDPYYYLQENRPRIPSYLSIDVDGRVLRFDSFSKVISPGLRCAYVTGPAEIVKGMEYVFMQSSQHVSVLSQMIIHKLLKKWGPAGFEDHVQRIVAFNREKRLHALAMADHWLKGFAEWNIPPGGMYIFLKVYDTGLTSVELNKKLMETHKVTVIPATGFYPKDAKMNDVAVLRVSIVMAEADEMAMVMKGLAQVIKEAQTAYVKKNDQVKIQTAVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV59</accession>
    <name>A0A913ZV59_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054961.1">
        <property type="nucleotide sequence ID" value="XM_038199033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199033.1">
        <property type="protein sequence ID" value="XP_038054961.1"/>
        <property type="gene ID" value="LOC119727168"/>
    </dbReference>
    <dbReference type="GeneID" id="119727168"/>
    <dbReference type="OrthoDB" id="10066368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000050">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000032">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="99"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="492"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="559"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="629"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="795"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="859"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="922"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="1215"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="1298"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="1364"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="1436"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="1522"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="1603"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2071"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2109"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2147"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2185"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2223"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2261"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2299"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2340"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2378"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2416"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2455"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2493"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2531"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2568"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2606"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2644"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2682"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2720"/>
            <end position="2756"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2758"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2797"/>
            <end position="2833"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2835"/>
            <end position="2871"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="18">
        <location>
            <begin position="2876"/>
            <end position="3077"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="3079"/>
            <end position="3115"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="3117"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2097"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2135"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2173"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2211"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2249"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2287"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2328"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2366"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2404"/>
            <end position="2413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2443"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2481"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2519"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2535"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2556"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2594"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2632"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2670"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2708"/>
            <end position="2717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2746"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2785"/>
            <end position="2794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2823"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2861"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3105"/>
            <end position="3114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3145"/>
            <end position="3154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3515" mass="378559" checksum="BBC77414C5279875" modified="2023-02-22" version="1">MFPLICCSGSGIYCANTSQVVICICICSSTYKHHLLVVAYVGRVVCNRLWDERVRRTGPSSGSYFSESGSPYSIRYSAKDGKGNKLDNLCTFKVIVKVRRCGTYLQLTQGEVSCSHQNLYGSQCTFRCTSGYTISGLSRRTCGSNGRWSGTAPRCRPIQCPSLPSTTCTDSNNYRSACTRSCSQPGFSIGQGQSGTRVCSADRAWTGSTPTCVDVQDPTITCPAIIRAFAAASQTSANVTWDLPEVSDNAKLDIVPELTTGLPPGSLFGRGSHAISYRAQDDARNTAACSFSIIVQVIQCADLSYLTGQRRTCSSQFNYGSVCQFECQSGFVLTGGQASIECQRQGDAGVWSAQQPTCQAITCPALSAPVNGGYLGNTNCSTAYGSWCRFTCNDGYQLTGSGVRRCLSQAGATEGFWDGYNALCKEQTCPRAYIPANAYISNSQDCPATDQIPAGTTCRYACQPGHVLTGSTEVTCGNDGNWNSTFPYCQVVTCDSSELPSPQNGFKNGCPHAEEIYSTTCTLGCNLGYMPTQPTYVMCTDDGNGTATWDANTIMCEAVQCDPLEMPGTPGYLPLSCTLNGVAVTDTDQRQSYGTICMASCDLGFTSSGSASRTCQLTSQWDGVPLQCTDITPPTLMCPPDITLFAGQRANFAVVGYEWEPIVVVDASGGIATLDSINGQPAPVNRSSIFQEGTHRLVYTAVDSSGNKGDCSVAVNIIVTRCPPLYGPQNSETSLVSGQGECDNAAVFGSVCNISCEEGYTLSDGSQQVTAECVKNIASSTVGYWQSPSVQCVPNTCQVPAVPNGYISGCNDQVVDYQSSCAFVCNPGYRSNHTSQSRTMRTCLADGTWTGVQPVCEAVVCNSLLNLTHGTVQPSDCSSQAELPYNTLCTFTCDDGFSLSGPYSKVCTDRGVWSDARPVSCTDHQPPVFTDNCPVYVNQIAPANMRQAIVNFLTPQATDNSDDVSVSSQDRSLGSGSSFTEGTTRLIYTATDAAMNSRRCDVYVTVQVLRCRPLQAPASGSLVQCPSNIYGASCSFACNAGYDLDGPSNRTCERVIDSDQMNGVNQLSGKDLQVKWSGKSPRCSPVTCPALADRLPAIRSGCFQYPPATEVLGTTCSWYCPYGYGGVGSQQSMCLANRTWDVVDFSCEERSCPALVPSAGMEISPAICLTSPTFNDNCFLRCSQSGYRVDPPAYDFIRCLGNGDWSGDSTAFTCIDYEVPHFTSCPLDILTYAPRGASDATVTWNVTATDNSGETPSIACNVQQPATLPVGEHSLRCTATDGAGNQANCDFEVQVKVHRCRQLNPPFYGDFVAACDNSHGSTCQVGCQNGYTLQGSDTATCSRNASTGLMYWAWNGQRPSCRIASCPPLSDQLIPLGGGVYPSFCRGPIHPYYGSVCQFYCRNGFDLVGPADHQRLTCLSNGTWDQNPSTLNVQCRDKVPPTLRVCPGSLSGSMSGQMLGVVLPFDIPMAADNSGAQLTVIKTPSDITSPYNFTRDTDVSYIFTDAGGNSVACNFSVNIQDNLSPVLQSCPKDQDLTTDQVKTLITWPEPVFCELTGDAMDISCNQQNGSSMQWGTHIIQCSATNLDNGKTTMCQFTVTITPHACIDLPAPRNGAKACDSWAYGRYCSMLCNANYDVTPRDSSRTFLTCGLNGMWSPPPGVFPNCARRVRPGQLKVLTDLHYFSGDCSSPDAQAKIKQQFIAILSSESGFDAICTQNVAECDVSNVEVSCAPARGAPSRGRIYRRDVGIWHESSLDFGFEFDQLNASSPELGWDELTEHAQKWLADMRAKGKLPSNRWVDRRRKPKPIPFKRSRRSTMSHTFTVSFGMNYQLPEDPTMSDYEFEDESWIGYDALYDIVDNVQVMADSGDLGLSVPGMEISSQPQLDYTEPGPACLHGYLPTPNLICVSCAVGEFFDNATLSCVDCPIGQYQDEDEEPHYTCKMCPTGTSTILAGSTNLTDCLRFCPSGQYSNTGLEPCFQCEKGSYQSEAGSVSCQQCPVGQSTARIGSTSLLDCADMCPAGSFSTFGIQPCVLCPLHSYQPQQGQSSCHSCPTRHITQVKGATDLSMCSLKTFCTAASCTNGGTCVEQLESFRCECPAGLTGSHCETDVMDCQQDSCFNGATCVDELNGFSCTCAAGYQGDDCSLLIDFCMNDPCENDGTCSSQTSGFTCACDVGFTGVRCEKDIDECLMHPCQHDGTCVNVDGDYLCLCVAGFIGDNCETNVDECKSNPCQRNGTCVDADNGYHCQCITGYSGNHCEIDIDMCANNPCSNGATCQDLDDRYQCACPHGYGGSHCELVLTPCDYHPCENDGTCTETLTEETGYKCECLPGFTGPECKINVNECASGPCSNGGTCIDGVNRYDCVCTDGFEGPLCEGRPDLCNPNPCHHNASCEDEGEDYYCTCPAGLSGRDCEIQVDACHDGETCFNGGVCASPSMDQLCLCPPGFVGEHCEININDCANSPCANEAPCVDGIQSFTCLCLEGFTGTLCEIDIDECASNPCHNGGACVDQISGYRCDCTDGFYGTDCENNKDDCVAGACGNGRCVDGINSFKCVCNVGFTGRRCNKEINECQSHPCANGGACWDLVNGFICDCVDGWIGEQCEINEDDCANTPCLNSGHCIDGLQSYTCQCLPGFTGQNCETNINECLSNPCHNQATCIDGINMFTCDCKKGKKGTLCQIDLGNCQPNPCKHGGSCTPTTTGFLCQCQAGFEGAECQTNIDDCANHQCLNGASCIDQANRYSCRCTPGYTGQFCQTVLDICSAEPCLNNAVCLPSADSTSHCICQAGFTGMRCEVAIDNCTPNPCLHDGTCINGFNSYSCDCPPGYSGTECDQDIDECIGNHCQNGAECINGINQYDCKCRPGFQGEYCSHHESSDFDVSLRGGRHSQYITIHRAIDKPLRAFTIMMWIRSGTSDGVILTYTTQSTGQTLQNAQIALSHPGSLDVYIQGYEFSSHTSFDDNRWHHLAITWDEHGGILKMYRDGYLVLIHSGMRSDTSINSGGELTLGELRSDGTQQESFTGSLSNVNMWDTALIPTIILKHALTCGYVVPGNLIPAAYFIDRGSLGEIQIQTPSLCDMVDECASNPCAAGSTCIDDVHRYICRCPPGFTGQRCQTNIDDCGTGPSPCDNGGTCVDGVDSFSCECPHGFTGQVCELEKVDGGWSEWSEWEECSQSCEGGTQSHRRSCTNPRPAYGGSTCAGPITETKQCNTAPCPSCRSVTRPFRGNLNCQVAGEEQNCTISCWQGYAFSRAILPSYQCGPSTDYKWSHETEDNPGLALPKCTKYKPPCKVAMEMQMAYSDDLTCDGVNVTSDNLVHQKVNDALTSNLQMVSCVQKKSCAVKQAQVIGCSPQMPGADARRRRRRSVKAVNFAIRLERDLDIPDQQNMTNEQVFNQNSTIEATFMLRNSAGHLINQSRTGQFAINIDSRVYDVNSKKTKSYGMPVCPPGTVRMEAEDVRCVPCESGWYNYLEDCYPCPRGMYQSLEGSTYCRACPRGRTTTGPSATEEGDCQVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWF6</accession>
    <name>A0A913ZWF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Progesterone-induced-blocking factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055854.1">
        <property type="nucleotide sequence ID" value="XM_038199926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199926.1">
        <property type="protein sequence ID" value="XP_038055854.1"/>
        <property type="gene ID" value="LOC119727851"/>
    </dbReference>
    <dbReference type="GeneID" id="119727851"/>
    <dbReference type="CTD" id="10464"/>
    <dbReference type="OMA" id="KCERDTF"/>
    <dbReference type="OrthoDB" id="299638at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="92237" checksum="9D09E1A8B314303F" modified="2023-02-22" version="1">MEPRDISSTMSELETGDISTSLATDLSISAEDESETDRRRDRKSFHQKQSKITKQLIERKQMIHDLQLLKIELSQKALIIDNLKAEQVSKVEELEERLADSQHQKQILQAKLEAQLNIHKQDSRQRQQRLQSELDIIVKRQQQLERTNAELQRRAGDVRSVLRDLELTETDYVELRAHSEEELSLRDYVALKLYDKVRPLQIELSDLRGWNNTLEQQVNTYKEDLARLQQTLTTEHNARSELETKCQRLTLELADTKASIQQGDYKRENYDRVKSERDHLEHDYMELKKQHTYLDVMYKNTLSEKEDITKQLSTVNQELSLLRQDKDYLHRQLNDLTGKHDHSESRLRDTTADLENAKRAREELYEKYVESRDRYKAEYESRLREELEAIRLRTDTEVDKLKTTTREMFERENRNLRENRDTALSEKDRAVAAEKECSAKYDQLLADLRQLQMTSDSKTSEMLGEVRMHKFEAERAHMLQEETLRNLDKTQVELDKHRQKIQVLTKEYYSMQTSSDRKATELEAQISELRAKLDIYEKLEKELDDVVMQAAENDNDETAERVLFSYGYGANVPSTAKRRLQHSVHLARRVLQLERINTSMKKELDNNKTQMHQLGEELSSATSLLDQAQQPYNYLIESIRGRDGQISKHKDHISTLEKDIGRLKQEREELIQARNQMSADLERLLNQREEMAVMKQVVLNMSQRYQPRVSGSHPGPVHIEKVPSPAKTHTSTSKRAASSPTKHHSSDSYKPAPTIFTSKDPPRWYSRLKEQNTSERSRYSTVYATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWG2</accession>
    <name>A0A913ZWG2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055406.1">
        <property type="nucleotide sequence ID" value="XM_038199478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199478.1">
        <property type="protein sequence ID" value="XP_038055406.1"/>
        <property type="gene ID" value="LOC119727554"/>
    </dbReference>
    <dbReference type="GeneID" id="119727554"/>
    <dbReference type="OMA" id="CTGSDKF"/>
    <dbReference type="OrthoDB" id="9993736at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="37671" checksum="4BAE39AB687E3798" modified="2023-02-22" version="1">MFLAHRYFTAGNLSLNPCPSLGQSRDARESDDSLDVYEAAKTEEKRQQKRKEKYEKRRDLQAQRPPKKQEGGCCDCALCRCLKRVPYGTLFAILLLAGGLALLTYEILYIQVVADMMFRFDADFSKTSILFEGTGTLFWVLIGAVAVMGLYGILLLVFACLTTGPSGQNTCGSEHVRCIGPCSTNILIMVTYVVCGVWIALTVVLAMPFTFMLMVRSYCKNITPSSCIDLSHYGLTGNVKTAAAQNTTMEPVCGNSLQSFCDNNGSIWLSSFLAMAACIMIVIALIHFLMALSANHTYQKMLSGDHPTRSKYGNDYRRAYGDADIPLQEPLNIHDESTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX02</accession>
    <name>A0A913ZX02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056049.1">
        <property type="nucleotide sequence ID" value="XM_038200121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200121.1">
        <property type="protein sequence ID" value="XP_038056049.1"/>
        <property type="gene ID" value="LOC119728043"/>
    </dbReference>
    <dbReference type="GeneID" id="119728043"/>
    <dbReference type="OMA" id="QMQDSWL"/>
    <dbReference type="OrthoDB" id="10063195at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF84">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="489" mass="55353" checksum="24761F42586F2D71" modified="2023-02-22" version="1">MECPDPTRQQQSGRTALVTRELACYKVDIAALSETRLSDKGQLTETGGGYTFFWCGRSSEERREAGVGFAIKTEHVKKLASIPEGINDRLMKMQLPLWRGRTATLISAYAPTMTNPEEIKDRFYEELDTLISAVPQTEKLIVLGDFNARVGTDSTTWDRVLGRHGVGKCNCYGLLLLGTCASHDLSITNTMFCLPTRNKTSWMYPRSRHWHLIDFVTVRERDRRDVRRQPQGQKVTKRLDVAKLKHLETVQDFQETLDTKLSQAQSSQDSVEEQWARLRDVTYSTALKVIGPKSRNYHDCFDENDVEIKPLLEEKHCLFRAHQSDPTCAAKKAAFANIHSKVQTRLRSMQDSWLSAKAEEIRGHADRHETKKFYAALKAIYGPQPSGSSPLLSADGSTLLTDKKQLLDRWAEHFNAVLNRPASINDEAIDRLPQVPINDELDLPPSDDEVSKATKKHDLLPDSQCGFRAGRGTTDMIFAARQLQEKCME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYA8</accession>
    <name>A0A913ZYA8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038056469.1">
        <property type="nucleotide sequence ID" value="XM_038200541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200541.1">
        <property type="protein sequence ID" value="XP_038056469.1"/>
        <property type="gene ID" value="LOC119728339"/>
    </dbReference>
    <dbReference type="GeneID" id="119728339"/>
    <dbReference type="OMA" id="MYPINAY"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="48209" checksum="B5245EEE5B29F937" modified="2023-02-22" version="1">MALNKLAMRQMWRPLASISQRFQGTTATAASTQTRNPEAKAEKVQFDWKDALNLERHLTEEEVIVRDQMNAYCQDKLMPRVLMGNRNEVFHREIFNEMGELGVLGPTIKGYGCAGVSSVAYGLIAREVERVDSAYRSAMSVQSSLVMHPIHEYGTEAQRQKYLPKLATGELVGAFGLTEPNHGSDPAGMETRARYNPAGKSYTLNGAKSWITNSPIADVFVVWGKNEAEGGRIRGFILEKGMKGLSAPVIEGKFSLRASTTGQIVMEDVEIPEENMLPNAQGLGGPFGCLNSARYGISWGALGAAEFCLEAARQYTLDRIQFGSPLAKNQLIQKKLADMLTEISLGLQACVQVGRLKDENKIAPEMISMIKRNSCGKALDIARMARDMLGGNGISDEYHIIRHVMNLEAVNTYEGTHDIHALILGRSITGLQAFVPAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0P1</accession>
    <name>A0A914A0P1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromodomain-helicase-DNA-binding protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057160.1">
        <property type="nucleotide sequence ID" value="XM_038201232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0P1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201232.1">
        <property type="protein sequence ID" value="XP_038057160.1"/>
        <property type="gene ID" value="LOC119728834"/>
    </dbReference>
    <dbReference type="GeneID" id="119728834"/>
    <dbReference type="OMA" id="WQNELFR"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03331">
        <property type="entry name" value="Macro_Poa1p-like_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000037">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="49"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="345"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="709"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="935"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="885"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116736" checksum="4BCAD377121B925A" modified="2023-02-22" version="1">MDRIRRKITDLSELKNADRIFVDGNAMAKFGLTGITYRPYQMDGLNWLIQRYHRNHGCILGDEMGLGKTCQTIGLLTYLFGSGKSQGPFLILSPLSVMGNWKDELERFSPKLKFFNYMGDKNTREELQSDIRHSKNWQVLLTTYELCLKDASFLRKFSWEVLIVDEGHRLKNQNSLLHQTLKEFTISRHILLTGTPVQNNLTELYSLLSFVAPSIFRVSLKERFLEEYEDMTDDTVKNDLHSILLPFLLRRTKNEVVLDIPKKTEVILYHGLSALQKKLYKAVLTKDYEAFQEQDPISQRPKTRLMNVLMQLRKVVDHPYLFDGVEPEPFQLGEHLVDSSGKLHLLDQLLTFLKQRDHKVLLFSQMTRMLDILQDYLGYRGYSYERLDGSVRSEERFLAIRNFNEQEETFAFLLSTKAGGQGLNLVAADTVIFVDSDFNPQNDLQAAARAHRIGQTRPVKIIRLVGKDSVEEIIIKRADAKLKLTNQVIEGGQFSLGGVGPAESATQLSEMLKFGLDQLLQSEDSSIDDVDLRGMLGSSVNGEWVEEEVTSTQHALEEEEMEEAPEGAMYMFEGKDYSKEPNASGKDREAFETLIVAEITEQEDNAELPRALRKHRSIKNIPELPLPQRKKKEYTPEELEERKRKREEAAAKREEAAAKKAKLMEEAEVRRAQERRQKLEQLWEANDYESANIAMETDEEESEDEENDDFELLHDGNEARAIQYVSGDVTQPINTGDKDAIVVHCVDDSGSWGKGGLFTALKRRSDQPETQYELAGKMRDLALGDAHLIGIDDKMSRSKGKDMVSLIVAQHRDKRNNLSGIKLYALNQGLQRVYRAAKKHNASVHLPRIGYATPGFNWYGTEKLIHKLLASKGIPTHVYYFPRHRAKRRSSSPPASGRHKPHSSAKSHDASAPSTSAASSSTHDAPEHEKGDGAGLPNIFRGVTVSFCDITEGDMKKLTRYVVAYDGDVSEVVSDKTTHIIADEETTEVQTLMDMKVENPDAVIVSTKWLQDCIAKQKRVNEENYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0W8</accession>
    <name>A0A914A0W8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057467.1">
        <property type="nucleotide sequence ID" value="XM_038201539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057468.1">
        <property type="nucleotide sequence ID" value="XM_038201540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057469.1">
        <property type="nucleotide sequence ID" value="XM_038201541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201539.1">
        <property type="protein sequence ID" value="XP_038057467.1"/>
        <property type="gene ID" value="LOC119729044"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201540.1">
        <property type="protein sequence ID" value="XP_038057468.1"/>
        <property type="gene ID" value="LOC119729044"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201541.1">
        <property type="protein sequence ID" value="XP_038057469.1"/>
        <property type="gene ID" value="LOC119729044"/>
    </dbReference>
    <dbReference type="GeneID" id="119729044"/>
    <dbReference type="OMA" id="ATEFIFA"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="304"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="971" mass="108394" checksum="52854B5D69846C7F" modified="2023-02-22" version="1">MAKWDCFNQLISRLFYRYGRLIARRPGIFLIVPLIIAGCLSSGMIFLTIETDAAYLFTPDNSRARDEVAEMSRLFPVNYEKFLPNRVLTTQEYGGSVVVTARDNSNILREEVMAEIIHLDHVLRSLELQAWGANTSITYADICCHFTHDECLEDPVLKLLNYSSKSVTTKNLTYPFSYLDLTDLSFSPSDISFEFPDFFDGSSNIFPFDLESVPDFSLLIPTGPQNISVNIGASLGGVVLHENSDIIKSAKALNIMYFLRSGTEEERVLAEEWERAFLSAFQTLYGQYLYIEVAVFASTTLSDELIAMATRVMPRFCLTFSLLICFAVFSCMMSDWVFSKPWLGQFGVISAMLAIASSMGLLSYCGLPFNEVSASMPFLAIGIGIDDMFIMLAAWRKTSIKLPVEERLGQTYAEAAVSITITSITDALAFGIGSITTLPAIRVFCLYSGVAIIFDYLYQISFFGACMVYTGRREAKRKHCTTLKPVLPRDEAPSKIYRLMCAGGVSKQSPTGEPKDHAVMRFFKDYYGPLITTPIAKIATIVLYCVYVGGAVFGCLHMTEGMQYKDIFSDDSYAHHYMIERAEYFTAFAAPISVVITEPVAYWEKDTQEQIENVTRNFEDLDNIYDSRFTDSWLRKYLEYLKTENTQSDSDNTTGLDEQTFLTTLQQDFLTNPLFEPFVLDVKFENISGRNVISASRLIFMPGNVSTTTEESKLMLDVRATADSAQLPLIVSSPPFEFFEQYLVVLPNTMQNLIIATVCMCIISLVFIPHPVSAVMITVCVISIELGVIGFMSMWDVSMDGVSMINIILCIGFSVDFSAHITYSFVTAPCDTGNEAAIFALHSLGMPILQGASSTILGIAAIATSPAYIFRSFFKTMFLVMTLGLLHGILFLPVLLTLLRPCMRLGKSKPKPPADLTTKTQEDKATKADDVQISLDQMPRTPPEKDQQTIDSNKDESSIDEEPKEIEVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A126</accession>
    <name>A0A914A126_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057354.1">
        <property type="nucleotide sequence ID" value="XM_038201426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A126"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201426.1">
        <property type="protein sequence ID" value="XP_038057354.1"/>
        <property type="gene ID" value="LOC119728959"/>
    </dbReference>
    <dbReference type="GeneID" id="119728959"/>
    <dbReference type="OMA" id="GEHEATY"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF46">
        <property type="entry name" value="GAG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="483" mass="54388" checksum="2B96BF48E526CF11" modified="2023-02-22" version="1">MEESLKKIALDWCKKEETRPSHSILLSMKLVATPTQTIALALTDCLPNIVGISRREDVGQDLTLVLCDFDKPVSFLKFGSEITLNFQPLPTSCRVIRLDDSPSHFPSKSSRVRISDLTKNGALDEWRNRPRPNSTESVPAIPSTSAGTSVSQPLPSDFSNSFSRCTLAANYRKLRCFSGLAVPSKDEDGYTAWIDHVEGQMDEWQDLDDAERRKRVREALRAPALSIINDLRRENPLATSRDYLKALDMAFGDTETNDELFVKFHSMTQRREEKPSQFLTRLQGTLRKALRRGIIPQDQSNRVRLTQFIRGITFDEMLLVNLHLRDKVDLPPTFLTLLSLVRKQEDEAKTKLAHRSQPAEHQGVHHLQHLSPHVPSFFPSAPHFFQHSAPLVPAPRHSMAHPRPQGERRGSGQRSYNAGAEDRGTLVNFCFGCGEQGHIRRRCPNPPNTEVVNQKLIKFILGERQSGNGSGRLPSGNQASNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1Q7</accession>
    <name>A0A914A1Q7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057762.1">
        <property type="nucleotide sequence ID" value="XM_038201834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1Q7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201834.1">
        <property type="protein sequence ID" value="XP_038057762.1"/>
        <property type="gene ID" value="LOC119729246"/>
    </dbReference>
    <dbReference type="GeneID" id="119729246"/>
    <dbReference type="OMA" id="GMCERPP"/>
    <dbReference type="OrthoDB" id="10506340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037506503" description="Sushi domain-containing protein" evidence="5">
        <location>
            <begin position="41"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23761" checksum="B6470BCE6A0A69CC" modified="2023-02-22" version="1">MPTARTGAGRAFAPWNPAGFVTLLWFHLGLLLQESVLVIAQSQCSSGMCERPPSTLSTQSTSPDTCYDSGRAVLLLCNPGFRLSGDNYTAKCSDGVWTPDSGCRIDLFTVFVAASASMVAILIFFLCFLCFYNWRCTPRKRKQHNVSKVKKEKKKRARAKADPEAANGRRGEPNGHVEDPDQFEDDFTDDEEEGVVPNRDTRYDDNIYQNQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A373</accession>
    <name>A0A914A373_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058044.1">
        <property type="nucleotide sequence ID" value="XM_038202116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A373"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202116.1">
        <property type="protein sequence ID" value="XP_038058044.1"/>
        <property type="gene ID" value="LOC119729522"/>
    </dbReference>
    <dbReference type="GeneID" id="119729522"/>
    <dbReference type="OMA" id="VCNRRED"/>
    <dbReference type="OrthoDB" id="6131158at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MADS-box" evidence="10">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="206" mass="23903" checksum="61B5115EA5191779" modified="2023-02-22" version="1">MTSNSQEDDIYKVLEESLEREKENSKVVYKKKVKYIDNSVTRRSTYHRRAQSLVRAAKELVISTRCEVDVHVKPTWGRGKTWRYSTQAERNDTAPAQTDPELVQQPSSSSLTITPRKHQNTVEPVHTIEPNKKLSCRVCGSDANKSSWLGCDHRNARTKRLDCQYWVHQNCIGLYFERDGDLEKVPFYCPKHGPSQKAHKRKRTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3K7</accession>
    <name>A0A914A3K7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanidinoacetate N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038058255.1">
        <property type="nucleotide sequence ID" value="XM_038202327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3K7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202327.1">
        <property type="protein sequence ID" value="XP_038058255.1"/>
        <property type="gene ID" value="LOC119729663"/>
    </dbReference>
    <dbReference type="GeneID" id="119729663"/>
    <dbReference type="OMA" id="HKMITPT"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030731">
        <property type="term" value="F:guanidinoacetate N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000096">
        <property type="entry name" value="Guanidinoacetate N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="232" mass="26455" checksum="7A73BB09E97431F4" modified="2023-02-22" version="1">MSSDRIFAANEDCAPSWKKADADFNANDTHLEIMGKPVMERWETPYMHKLATIAASKGGRVLEIGFGLAIAASKIEQQNITEHVIIECNDGVFERLEEWAKQQPHKVTPLKGMWEEVVPTLKDEQFDGILYDTFPLSDDTWHTHQFPFLKGHAYRLLKPGGVLTYCNLTSWGEWMKSKYEDIEVMFKETQVHHIVEAGFKADNISTELLPITPEPGCKYYSHNVMIAPTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5T6</accession>
    <name>A0A914A5T6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058771.1">
        <property type="nucleotide sequence ID" value="XM_038202843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5T6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202843.1">
        <property type="protein sequence ID" value="XP_038058771.1"/>
        <property type="gene ID" value="LOC119730057"/>
    </dbReference>
    <dbReference type="GeneID" id="119730057"/>
    <dbReference type="OMA" id="CVATERY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="16"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="46955" checksum="6E1FF95724C518AF" modified="2023-02-22" version="1">MASSACGSDGRAGWFAVLAMWTRLFIWSAVFKTIGMMLPLLQDQFDTTTWILGWITSTIGTTTGLFAITSRLMGRWFSPGYVIMTCGAMIGVSVIMASFATSPVHLACVFILLTGTGFGISGVLIKEAIARRFTANYATATGIARTGDSIGLFVCAPIVQVFIDTYGWRGAMLLVGAISMHLLVCGALMQRAGAPSASRYQKLPADDGISKHPSQLPSRCTSFYKNLFEIFDIRLLSDFRYWSVAIIACCSKIAFHMWLIYFVSQAKSNGFSLQEAATFVTVGGVGGLIAKLVQGFFLDRGVISSFHLTATAVAVCSVSYCATPWLTSYWPMMTSSLLILTSSGALSCLHDVLSKQVLGVDLLVGTFGWIYFTAAILEFSLGFLPGLLFDTTGSYTTAFVFIGSLQFLPMFPLLILRYYRCFERDAQEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7Z9</accession>
    <name>A0A914A7Z9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059908.1">
        <property type="nucleotide sequence ID" value="XM_038203980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7Z9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203980.1">
        <property type="protein sequence ID" value="XP_038059908.1"/>
        <property type="gene ID" value="LOC119730917"/>
    </dbReference>
    <dbReference type="GeneID" id="119730917"/>
    <dbReference type="OMA" id="PYACINF"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="359" mass="39601" checksum="210A0294BC12E125" modified="2023-02-22" version="1">MVVDTSDLNCSDLYQLDLSDDIKRASTYLINPGSRAIALGVQILALIIGVPGNVSFLVAVARVAYMKTITNIFLVNLAIADIIFLFFTIVSYLLYLPAPVRSHIHSLLNLSCSVSFAIPFLTYFTSVATVCLVSAERYHAICRPLKHLAVNTKRRAVKLVLGTWCVGLAFTCLAVLQYADPVRICVTWPSGGNDTEKFADLPDIIGFCLPLAPWALVVGNLASSVPFMIALVGNAFMYIQIIRTLGNRHITNTDEQDESVSRARLVRNQVARMLVINGTVFFICQFPYACINFVYISGLAKGMSFLQVNDLQNSLRVFSHSLLFLNSAINPIIYCAVCPSYRRAVRTAFTSSTHSTNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9Z8</accession>
    <name>A0A914A9Z8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060588.1">
        <property type="nucleotide sequence ID" value="XM_038204660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9Z8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204660.1">
        <property type="protein sequence ID" value="XP_038060588.1"/>
        <property type="gene ID" value="LOC119731474"/>
    </dbReference>
    <dbReference type="GeneID" id="119731474"/>
    <dbReference type="OMA" id="EWRDYIC"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="21965" checksum="64B2333C06D21B79" modified="2023-02-22" version="1">MWYGETHPAGTEKPIQAVTENSTQGGSEKPTPSCTEKPTAGGTENPTPAAECSSPQPLGMEDGTIQDDRITASSSNNGYPATDGRLNNHNRWLTGRADGNPWIEVDLVRSTVVTGVTTQGSPGGSWYVMRYKVAYQQQPSSQRKHVTDGNRDIKVFIGNTDSDTPVTNLFDESVEATVVRIEPTEWNKGVALRLELLGCRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA34</accession>
    <name>A0A914AA34_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060715.1">
        <property type="nucleotide sequence ID" value="XM_038204787.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204787.1">
        <property type="protein sequence ID" value="XP_038060715.1"/>
        <property type="gene ID" value="LOC119731594"/>
    </dbReference>
    <dbReference type="GeneID" id="119731594"/>
    <dbReference type="OMA" id="VYACPLM"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="9">
        <location>
            <begin position="657"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="10">
        <location>
            <begin position="857"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1557"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1793"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1848"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2029"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2134"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1314"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1359"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1428"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1557"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1600"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1641"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1886"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1899"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2029"/>
            <end position="2040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2164" mass="242148" checksum="7724860BCE9CD2F9" modified="2023-02-22" version="1">MGVPKFYRWISERYPCLSEVVKENQIPEFDNLYLDMNGIIHPCSHPNDEDVHFRITEEQIFEAIFHYIEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAREAEEREKEAMSKGEVLPSEKRFDSNCITPGTPFMVRLHEQLKYFVRQKLTKDPTWQGLTVYLSGHETPGEGEHKIMDFIRSERARKDYDPNTRHCLYGLDADLIMLGLISHDPHFSLLREEVRFGKIANQKRPTTPEETTFHLLHLSLMREYLEIEFSALKRHIDWFDMERIIDDWVLMGYLVGNDFIPHLPNMHISHNALPMLYKAYIEILPSLGGYLNEHGTLNLPRFEKYLIHLSKFDKEKFEETFSDLSFFSGKTDIRAWKSNRAQAKKEQEKERRAAKANSNKFSVLDSLDDVMGLKPGAGSKVTGLSSDSSQGDSLDEEDGDTFEEEFIAHKRAYYDDKFEMENITDEQLSVIVYNYILAIQWILDYYYNGIQSWGWYYPYHYAPYMSDLRGFSNFKLKYEKGQPFLPFQQLLGVLPAASKELLPEPYQKLMTMDSSPIIDYYPLDFASDLNGKLQQWEAVVLIPFIDEKRLLAAMDDVSKYLTEEERSRNRHGPHLMHMYEETMNYKYPSSLPGHFPDINACRVRCQELDKGIFHLDPRQLRQGLCAGTKTGVYFPGFPTLHHLKFTTQLRKDDIKIFQQNSRGESIILSIQTDNADVEAGDVANEVFGKNCFAEWPHLKEVKVVAVADDTTRYELVESKQKSPEEAEKPSVKKRDMSDFDAAVWVKDIKAIQERYHKRKGVMIGPSYVLIYACPLMGRRYVSGHSGVVTLEKQWSSTPVTYAYQMMVKDIAVHDSTFKQFKTLEEVFPKDSHCFMLGAPNYGCQGSVVDIEAGRIRVLLSCPVEPNLNQLRNSQSHYEVQYLPSYILAQRLSLPSLIISRLTGSIFVGRGSKHSSSVAPSNNFNIGLNLKFNKSNQEIQGYSKKDETGTWLYSIKVLEVIKDYMEKFPEVFRHIGQNPRTDTYFEDNLFEGKAGRMKQLQDFIKALPCAKVSKVDVGLKNLDEPIIKLIEAEVQKVAGLKVKKQKLSVRPHLLYKPLHYLGNLIPDPQVEHELFDRVVNVREGYTVPLGLHGVIIGIQPGETILDFMYEVVFDEEFPGGLVIRCTGTRGYRLPTTAIINISYGLRKEQGQQQSNKPMAVVKPQAFQQPNAQTQSRGWYSDTIGRLGASQQQSSQRQQQQQQQQQQQQQQLQQQQQRQPQAQVPSKSTSAINYKAALSQKNNSKQQKEQGSVGQPAPAMKILTRSGPKMIARSPIKEPSTGKGTSPQNTPPRRQSKEEIESKRNASKERRKDSGSKPELVSSTRVVSDKPLKESQSRDEIKATKSPLIKTTKRTPENEADEFAIMWRNLQKNSNSGTSSPVTDKESSRSDELTSPLASGGQTPLSEEEVVQPSIQMQLALSALPKVEAPVSKVMEDNTNLEEGDEKECEGEEFEVDTEARMTPRTYVKSGTEELCRMLNITSMSDDNDPPKDVAVPHSIVIEPSTGKKQYGVRLTVDQLFAGASVKSSSPSISPVPVTPTNPASATMVPHGVRQPTAYQPHPLAQQPGPVSGPHPGVVKAPVPLHPNGTSDQPRYQRQGLPPGSSDPLPIPRSGPLPQPPGQVGIPASAGVMMLPQGQLHRMSPGSVPQGAASPGRFPAGMYPAQPVGSPGQHMPLHVLQGPPLVAVGPGHQGMPHPSSFIVQPVQKPVQQQQQQQQQLLQATAPQQQLGVQQLVQQPIGIHGPGNQSPASMVKPVPTQMDPQPAVHLQQKPASVAPNVNASNTNQYPASAAQQQGVVVAQVNAPGFNVVKPGPFQAPFDLRSQQQQQQHHVGVPFASPGRPHSGPHAMSSPSQPPNLRPRPAFPGPQQGHPLPQGYPMRPQTPSHALLMWCQQRGLPSPKYQFQKNNTTGQLRGVVQLADGKQFYGQDCPTDAMAVDAAAHVAMTNLTSQSPRGPAMQQMRPTTRPSFGPMGPVHGPMIHTSGPNPFVPLQVTKQLNSPQRSTSTETDAESPGRTLPEQQMEYPTHVPSSQIAPPFARVDFAQARDQSGNMDESKLSSRRELYFGKTIVEIGSPIIEVAESVGPRKSSIDEISGAVHSEMRDSTAAAAKRRRSSSKAKLAINFGGKPGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABI7</accession>
    <name>A0A914ABI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038060816.1">
        <property type="nucleotide sequence ID" value="XM_038204888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204888.1">
        <property type="protein sequence ID" value="XP_038060816.1"/>
        <property type="gene ID" value="LOC119731681"/>
    </dbReference>
    <dbReference type="GeneID" id="119731681"/>
    <dbReference type="OMA" id="KQMADHV"/>
    <dbReference type="OrthoDB" id="5962960at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="11">
        <location>
            <begin position="146"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="875"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="959" mass="111304" checksum="69FDFE1C6C000213" modified="2023-02-22" version="1">MEVSEAQNQQALGVVKKLYSVVCQKLSNSELDKVKTFIRKNNLWTHTGITEDELHRAKTVQKFLSLMNRKASPATLHVFQNLAAFMQHLSRRDILEDIKSANKEMSNIVGPRVKIDWASQTVFVHVPEELRGQQEQEAYRKALKEGHKQVHRTRLMIVGQERVGKTSLKRSLTHQRFNNDEPPTEGIESSVCKIDIKHATSWCLHQEGDESTSFRREYENTLRSEASFNFHNFFMQNYPVDIEVPLGMPVMPTYPVDQATLPAAASPPQTAIPQQDGKDRNSPENEQAQKPQISVRKRHVSGVEEPIVFSVWDFAGQELYYTLHKTFLSSRAIYLVVFNLCQDLDKPVPVPASARSDDASSSYTDRMTPIQYLDFWMRSIFTYTKENSSEKRLEQKSPPIFIVGTHRNSVGGVDLPDYERKQMIDKIFTRIRTEICNKPYVRFVVQNFYAIENSLETNNSKIARLREHIQSTARKEPYMGQLIPLRWLQFDDKKLKEVAKKDRTPVLTLKQVKDDFGVKDETELLTMLKFYHDLGHIIYFGGDGDKKSQALKDVVILDPQWLIDALKKVITITPPRKQMADHVRSWKRLKEVGILEDMLIDYMWREILPHKKALLDLMDKFDLLCERVDQTQEEDCSSPSAAVTSPPTFQRQHSKTSPKDEVSYYVPSMLQRQTSTSNQSQQPKNASVFYVDFYGFLPDALFHRLVVRALRWSQNKGGNNPGLQYDAANFFVDAQHEFVLQMVRKKDLAYVKVSVMRAPVVHTRRRHSKIEKTNMRKTPSPDVTSKVHGFVEENLHNLQDMWIKRIHYCISVLCPNKHKVPHFLPLDECLKKTEVPCRFENPQALIRTDKYQAMFKQESSEEENSPHEDRPPIMSDIYFRELAKDIGGEWEQLASYLKFKKEDVDKIKIDHRGVNEQIFQMLVQWSEKSGNKVDKMRKELIGALRQVDKPKLADKVWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACD0</accession>
    <name>A0A914ACD0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038061126.1">
        <property type="nucleotide sequence ID" value="XM_038205198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205198.1">
        <property type="protein sequence ID" value="XP_038061126.1"/>
        <property type="gene ID" value="LOC119731881"/>
    </dbReference>
    <dbReference type="GeneID" id="119731881"/>
    <dbReference type="OMA" id="WITFTRI"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="31447" checksum="C69F51A2AECDCDE7" modified="2023-02-22" version="1">MIVSRLNVDPGSEIGDEVHARNQGLLTDLKGMWSMLMDIGSVKLFYVITRIILSKLWRTLWYWNTTEDRLLAYVKKTAVEGDPASVLAAIRKYNDYEWTMALHPEKKLKTDEVVRKATPEICFEMGCYVGLSAITVASQIPPGGRLITVEYVPKIADVARELVHFAGLDQVITVITGTAEDAIKVLRSEYHVDKLDFVFVDHCKWQYLPDLKLLEKERLLRKGTIIMADDMLWPGAPDYLEYVENDPKYQTERFNCKAILLNVPVAMAISVYQGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACW0</accession>
    <name>A0A914ACW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061755.1">
        <property type="nucleotide sequence ID" value="XM_038205827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205827.1">
        <property type="protein sequence ID" value="XP_038061755.1"/>
        <property type="gene ID" value="LOC119732368"/>
    </dbReference>
    <dbReference type="GeneID" id="119732368"/>
    <dbReference type="OMA" id="AFTRKFG"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001266">
        <property type="entry name" value="Zinc finger protein 662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001134">
        <property type="entry name" value="Zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001450">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="674"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="819" mass="94230" checksum="DDDF76B9E19AFDC2" modified="2023-02-22" version="1">MDTKEHELICQQRVDEGDKPFVCATCGKAFRQQSKLRRHDRVHTGEKPFVCATCGKAFALLNSLKQHDRIHTGEKPFACKTCGKAFTTQSYLRQHDKIHTGEKPFVCATCGKAFTEQSNLRRHGRVHTGEKPFVCATCGKAFSLRFELRAHDDRMHIGEKPYICATCGKAFFQRSELHTHMLVRNHSQSTGDNTHSRALSDLKRFGSMKGRRRFSEVYSASTYWYLRGPVERPFLRNVLRYHKMVHAGQQPFVCEKCGRAFTRRRDVRRHDRVHTGGTPFYCDWCGKAFTYQSNLRTHERIHTGELGSFICSLCGKTFNRQTDLKGHYRVHTGEKPFVCVTCGKAYAHQKSLNSHRRIHTGQNLRVRITCGKTFTSQLGLNRHDRIHTGDEKPFVCEICGKAFTRKFGLRQHERVHTNEKPYVCQTCSKAFTNQKGLDYHERIHTGKRQFVCETCGKAFNRQSCLNIHNRIHTMEKPFFCATCGKAFTRKSNLQQHQKIHTGEKPFVCETCNKAFVREKDLCRHGVVHTGEKPCVCVTCGKAYAHRQSLNRHGWVHTGQKLFVCVTCGKTFASQNGLNRHDRIHTGEKPFVCEICGKAFTRKFGLRQHKRVHTNEKPYVCQTCGKAFSQRGNLDQHNRVHTREKPFVCEICSKAFTYQKSLDYHEGIHTGERRFLCETCGGKAFNRQCRLHQHVKVHTGEKPFRCETCGKGFTQKTYLKTHNRIHTGEKPFVCATCGKAFTHQSYLQPHQRIHEKPFVCETCSKAFAEQKELRRHVVVHTGEKPFVCSTCGKAYFRQGSLKRHAKVHAGGKSFIFKTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADC6</accession>
    <name>A0A914ADC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBZ2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061935.1">
        <property type="nucleotide sequence ID" value="XM_038206007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206007.1">
        <property type="protein sequence ID" value="XP_038061935.1"/>
        <property type="gene ID" value="LOC119732479"/>
    </dbReference>
    <dbReference type="GeneID" id="119732479"/>
    <dbReference type="OMA" id="TSSHIRT"/>
    <dbReference type="OrthoDB" id="10063431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031490">
        <property type="entry name" value="UBZ2_FAAP20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51906">
        <property type="entry name" value="ZF_UBZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBZ2-type" evidence="2">
        <location>
            <begin position="927"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="963" mass="105113" checksum="828AD67D42AA76D4" modified="2023-02-22" version="1">MASASATGTDRRGKLSLKRKRNAENCVEDDDFVADSNQTKRRPDGGGRKTDRPRFSKGQSADEKSKSSLKVKARLPRYDSDSATPSCPSVRLVRNQASLGSSQLTSSLGQSTLPDLPGWYGLKVKEEELQVTGTEVIKVGGVSVKWRPLPAYCRMCLVRSKQKRAAESRDRLRAFAGASPNIKRESCARNAELVPDQLIPGDIKSEPLQRSTDPRNGAMSEDSNREIDVKSEILKQKSARTVNSEAGNLSKPQLNHAIKIERKLHQNVPVKPQNGSSCHSKQSTNPLDDRKPQSLHRKALSLSATKRKGQKLRLSGELKVPSLKNENGLPRLAQTESGLHAKVGKLEPRQMAFSNTRTFPKDAQHSSPSTQAIGLGGLPKVVPISSEESVEVLAKIRSNLQHRISVKKVLSASRRDGTCGALARSDPSNRQSVNPDALSKSSLTPTHTNSVAALPTRFAQENLDSSEVIVLDSDDEVETTSSSPLTGFKRKLSRSSSDTDKRFCKKPKLIKVSGTGASGSLATRLISRPKSPVPKHCDGQVKPGFSKTAQTRLDGMLVRTSPGHTKVQPSTPSRNSQESSLGKPITAYLSSSEHPKQASSNNHVCKQGSLTQTKHLSAASSNSSAKKSAWNTSTNVKPLFKKQRSGQLNSVQVQNTEQVLTKVQADSFTGSSSYTNNESQKKLNFATAKGMDNSRKTLHKGAAGTLNESPQGKMTGFTLPATNTNPGQNPLSKQPRNQSVFRSNQVVGPLGKPEEKPSTSTGSAKNANIRLHPEFQTARNIRTDRDINLKRDKQPNTLGDNQTTQGLHGRSHPKQDTNHRNMPKGVNRDIYVSPHMDQHTNQSVFRSNQVVGPLGKPEEKPSTSTGSPKKANTRLYSGFQTARDIRTNWNITPKRDSQPNTLWDNQIAKGLYGRSYPYQGTSDSGAILSCPLCGLQFPKRLTPEERDEHIALCLSVSSEDVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADD5</accession>
    <name>A0A914ADD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061496.1">
        <property type="nucleotide sequence ID" value="XM_038205568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205568.1">
        <property type="protein sequence ID" value="XP_038061496.1"/>
        <property type="gene ID" value="LOC119732159"/>
    </dbReference>
    <dbReference type="GeneID" id="119732159"/>
    <dbReference type="OMA" id="WEDAVNY"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="230"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="104885" checksum="291A185D6925B8B8" modified="2023-02-22" version="1">MANAAQTVDSLLASLVGMGFELDRCQAAVNCGKLTVNDAVEWLLQGHGAEDTIPSRSAPTLSLNQPSQAGPATQSSDASYLPFSLPPVSAPSSDPPGDSHQGLTHPAVPPTSDESRFQQQDVVSRFSLSEKKRQDKERWEKEQREKAAVEARQARLQAKQARSNILKNIEADKEARHQHGKLPTSLQPETSVGTTPPTQPAATAAEPPGGAKMEASQRATASQESKPMPSAPTMCMLQVRLPSGQSMREKFPSTATLQTVVDFIKSQHSDLIHINLIQPFPHRSFTSRELDSTLEELKLTPTGNLVVKLGTAEPAALQQEAQSLPAASPDRESQPQPTNQQQPPPSLSQLLPHHPPPPAPPHHRSQSSHHSWGHGQALSPGDDSSPANEEQEEEPMEVGGARVDFDDLGGAMDDEEMMGVDEAGVGGAEEAMLWGGPAPHPHPMGAAGRAHHDWGDGNRLIDGRRPLNFNYGFGQQGEQGDVEEAPSPQRAAAAALSRLAAAALSQAQSPTSPTDKPITALQDLCLRCVSKRIEGRTRQPVTMLEALPPHLASRLVEELKKAGVLRPKTLNLFLPCHLQYLTLDCYKYTTNELLQAARLHVHISRLSLSACPLLTDQAFLSINSLKKLQYLNVSNNKQLTDGILYSIKDLSNLVTLALEETSVSDEGVKVLASSPSMSQLTHLSLNRTNVSDSMLPFLTVFTNLRSLGLEQTKVSQLDGIEALVSLRSLNIARNRITLQALDRLSRLPELTALNVMLIEGMTGDDVLHHLQGLELKQLQMPDRHTTTNMGLCCIAGMPLVALDLTDYIHITDQGIHHIADMTSLTKLSLNNTKITDVALEYIKGLVELKELHLDRTAVTDHGAMAIGSFRKLEVLSMAATQIKNRFLRSETLNKCEHLTRLNLSKTDVSNRGIEAVQLPHLSLLNLDSTCVTVEGANRMHGCPSLKLVRTNNLRVNRGEDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADM8</accession>
    <name>A0A914ADM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dehydrogenase/reductase SDR family member 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061838.1">
        <property type="nucleotide sequence ID" value="XM_038205910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205910.1">
        <property type="protein sequence ID" value="XP_038061838.1"/>
        <property type="gene ID" value="LOC119732412"/>
    </dbReference>
    <dbReference type="GeneID" id="119732412"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28822" checksum="DF58F2D139113C22" modified="2023-02-22" version="1">MTSKEESMRRWAGRVALVTGASSGIGKAIARTLVQHGMKVVGCARNVIAIEEESSLLKESSSPGLLHPIQCDLSQEKEILAMFDQIWRKFGGVDVCINNAGISHAASLLDGDTQKWKNMLDVNILAVAICTREAVKQMAQKGADDGQVININSISGHKVTQSKDSHFHTATKFAMTAMTEGVRQELREVGSMIRIASISPGIVETEFVSRMYPDNPSKPAAMYKSMQCMQPEQISSTVQYIMELPPHVQVHDVQIRPTEQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADX6</accession>
    <name>A0A914ADX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062007.1">
        <property type="nucleotide sequence ID" value="XM_038206079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206079.1">
        <property type="protein sequence ID" value="XP_038062007.1"/>
        <property type="gene ID" value="LOC119732521"/>
    </dbReference>
    <dbReference type="GeneID" id="119732521"/>
    <dbReference type="OMA" id="DFWHYPL"/>
    <dbReference type="OrthoDB" id="6102451at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="29"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36502" checksum="423B5D6F6D2F353C" modified="2023-02-22" version="1">MSDEDPSPVWFNVLRCILLTITTILIICGNSFCLIVLRRVNGIHEVTRLFMASLAVSDLITGLFVASPMIVSTAMDRWPYGDVFCGIYGVGKYVCYYTGLISLIAVTVERYIVVVSPLRYNTIVTLFRARVAVACIWLFAFAITMFFGVSVHFIGDVDDDEDNCSLDTSKGDFWHYPLKYMAVAFIILPVVTVLVLYSHILLIARRQIRQIAAITPLGPMSDEERASMKTRKANRRAAGTFLIVTMTFAMAWMPSAVRKLNKLATGNGDTMYTEFLARFCMLSNSWLNVFVYYVRNDSFKYTARRYIAALIGRRGSDDIEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AET5</accession>
    <name>A0A914AET5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062021.1">
        <property type="nucleotide sequence ID" value="XM_038206093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AET5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206093.1">
        <property type="protein sequence ID" value="XP_038062021.1"/>
        <property type="gene ID" value="LOC119732535"/>
    </dbReference>
    <dbReference type="GeneID" id="119732535"/>
    <dbReference type="OMA" id="CTHTLAV"/>
    <dbReference type="OrthoDB" id="430300at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="490" mass="52380" checksum="33010BB40037163B" modified="2023-02-22" version="1">MAEGGKNLGQLLPLKLVLTIYAFLSGLVFGAIFTASLQALRFLVSNELGYGEGDDKMASMGHNSPCSALNDTYANNASAAANVEVQERTALLATVTSIVGNIPSAAVTILASARMDSDSANEKSIQLLPCVGVTLHMAIYIIIMQFTLSPWFALIPIFILGISGSFFLQFATMLKYLGKITDEQDRSSNLLLLAMFNFGAQGIAQIGIGYLIEGAGFTMTFTILFLICALTTVFVFLFLPNTESNASPTDGTDNDVGTTSRLPSLCTHTLAVFKDPDTGKWNSGLIVSALAMFLYSQISFYFLAILQIVALGEPFCWSPSLIGYFSAAKLIGVAIGMTLGTKILRTWFDDNGLIQIGFISMVISTVIPIYARTDAGLFLVVVFGAFRMIPGPILTANVSKMVKKNSMGSVFGVTMAIECLASLMGPTVFGTVYEATVEDNPHLVFRLMAGMTAIPSALILCLQCWECTSGAANYREGGDDTLLPSSSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFV6</accession>
    <name>A0A914AFV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062613.1">
        <property type="nucleotide sequence ID" value="XM_038206685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206685.1">
        <property type="protein sequence ID" value="XP_038062613.1"/>
        <property type="gene ID" value="LOC119733106"/>
    </dbReference>
    <dbReference type="GeneID" id="119733106"/>
    <dbReference type="OMA" id="CATCQER"/>
    <dbReference type="OrthoDB" id="444601at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="25546" checksum="159C7D1910152E5E" modified="2023-02-22" version="1">MQQLAATIREGWPDLKSQVSANLAPYWNFCEQLTLEEDLIFKNDKVIIPASLTKLMLTKVHQSHQGIEKTKRLARGIMFWPNMSAQITDMVSRCPICSANQHKNRKEPMVPHEFPLRPWQKVGSDLFEIGTEQYMVLVDYYSNFIEVNKLASTKSSAVITCCKQQFSQYGIPDELITDNGPQFTSAEFRQFTKDYGIKHTCVQRHHRCTPSPMAEQKKQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGP6</accession>
    <name>A0A914AGP6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063160.1">
        <property type="nucleotide sequence ID" value="XM_038207232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207232.1">
        <property type="protein sequence ID" value="XP_038063160.1"/>
        <property type="gene ID" value="LOC119733866"/>
    </dbReference>
    <dbReference type="GeneID" id="119733866"/>
    <dbReference type="OMA" id="STVECGF"/>
    <dbReference type="OrthoDB" id="10064351at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="488"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="796" mass="88617" checksum="DB85BBE4BE8AC6D9" modified="2023-02-22" version="1">MAVDGLPLSTFKTLVRVQKANGVKLIEGTESSNKAREFVHEIANAIRAKLSSILCSSTAFSVLSDGSQARKTSSEKELVMVQVVKAGHSVFYVAALENIDSYGDANAENLHKSLDNALENKLKIPHDKYTKALVSATADGASVNTGIYNGLLVRFQKAERPWLVSIHCVSHRLELAVKDTLMKEGPFKQVSEMMTTLYYLMKQSGKFKRHFEVTASALHCQVYRFPKVHGTRFVGHQRKGLKILLHNWIPLAQAIENSIASKKHTNMDAKLNGILKKLRSLQFLAMCSLLYELLDIVSSLSLKFERGDVQTFEVLPAIDVTKVRLQDLLEDEDPVKKAGYSIEGNSVLCNLPKGGHMRKSAEKRETVSVELDGMSHAQRRSDTSTSSTTDESDMSRKLKQKVVPALMKKLDERFQSFSNTLFKNMFWVNPANWRSDAPETEIESLQACSNHFSTTLVASGFDSSKIKLEWQTLKIVHKSFYQGMEAGEMWAKVLQYRRKEFPNLCLLVELIMAIGVSNSTVECGFSMLTAMLSDRRLSLSHTTMEDLLVIKANHQVWSESERDDIIEASLKNFMSSKRRKRQVQNSTPNFATVEHGHSMPKKMKCSNVANSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTLDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTQDSDTDSSTSDSDLSGQTDLDNQSGTEHVSDDEPDHGGGPSRSVEQEDRGDKDFDDTDSDSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI90</accession>
    <name>A0A914AI90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063109.1">
        <property type="nucleotide sequence ID" value="XM_038207181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207181.1">
        <property type="protein sequence ID" value="XP_038063109.1"/>
        <property type="gene ID" value="LOC119733809"/>
    </dbReference>
    <dbReference type="GeneID" id="119733809"/>
    <dbReference type="OMA" id="SWHRTSF"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="123"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="26399" checksum="42B065A9A11BA040" modified="2023-02-22" version="1">SIALLLGNSVKLRASVTGPVPSDGDGLASQACPMCCQGPAAIPGIPGLPGSLGQPGSKGEPGQKGDIGQIGPMGERGAAGSKGDEGIGQPGKIGPRGVPGVAGPTGKTGVKGQKGEPGETPDDSNQRVAFTVVRTSHSDSSSGNDYRLPFQETETLLPGTSFDLETGTFTCGVPGTYVFMFSVCNYYSSGLYVQLRKNGFVVVSGYSTDSSHNEQVSGNAVVVLQRGDTMYLTMQGRAVSDSWHRTSFSAFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKT6</accession>
    <name>A0A914AKT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meteorin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064181.1">
        <property type="nucleotide sequence ID" value="XM_038208253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208253.1">
        <property type="protein sequence ID" value="XP_038064181.1"/>
        <property type="gene ID" value="LOC119734715"/>
    </dbReference>
    <dbReference type="GeneID" id="119734715"/>
    <dbReference type="OMA" id="RISDECD"/>
    <dbReference type="OrthoDB" id="6092325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF3">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36737" checksum="3ADFDF462E933561" modified="2023-02-22" version="1">MSLHGRYKGPGPYPPVVMYCLIVGLITSFLLDVVVGSYSNSLCDWSGSGLTEDPADRLIHQLYFQCSRGHVTWSFPTSAIRITFKKGNSDEDFLACFKTSATSSGVNIYKETHNTLKLLVVLNSLESQRDFYEDGHEHRTVSSNSGASEVHCFSSENGRATLFLEASPDNLGIVKQVVDIHYILEPLPSSQPQDNLEDCRPCNDSEIVRSFCSSDFAVKSSMRDVMHDSISQTAYIDLSISHVFRQRDHIFSPASHSRYSGVVVKPLRCGVRWGEGHFLMMGSLVLGQPRLGCSPRYSQARRIAKEFTAKGLNECDLGEIIQLHHDNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALA5</accession>
    <name>A0A914ALA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related C3 botulinum toxin substrate 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064346.1">
        <property type="nucleotide sequence ID" value="XM_038208418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208418.1">
        <property type="protein sequence ID" value="XP_038064346.1"/>
        <property type="gene ID" value="LOC119734838"/>
    </dbReference>
    <dbReference type="GeneID" id="119734838"/>
    <dbReference type="OMA" id="NVRAKWA"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21861" checksum="397C16A884537E9F" modified="2023-02-22" version="1">MMQSIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDIFLICFSVVSPVSYENVRAKWAPEVRHHCPQAPIILVGTKLDLRDNQETIDKLKERNLHPIKFQDGIQMNKEIGGVKYLECSALTQKGLKMVFEEAIRVVLYPPKMPKKKKPKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALB8</accession>
    <name>A0A914ALB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family. LRRC14 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064224.1">
        <property type="nucleotide sequence ID" value="XM_038208296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208296.1">
        <property type="protein sequence ID" value="XP_038064224.1"/>
        <property type="gene ID" value="LOC119734751"/>
    </dbReference>
    <dbReference type="GeneID" id="119734751"/>
    <dbReference type="OMA" id="MVYEPVI"/>
    <dbReference type="OrthoDB" id="6479713at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="503" mass="56823" checksum="BC9BB2C5A77BDCAE" modified="2023-02-22" version="1">MFNFDILYGASTAATRMFGPRDGVPSLLDRCASFIVTSWHVTRASLNVLPHDLYEVLLGEACQALLSYRSGTPGLFLTYIVQRWPSVVLKPGSLIWRYRLDVKNNKKTSELVMHIVNGICQPESQCKLTMVDLSDIPMNGSTCLILLQKVFASLNGRSLTVVLDLALDAENYHPIRRLLRDVRHCKNGSLKVQCRRLTVNSLGKDKLLKVTGLVEPDIIVALNLDWNNLEEQGLSAVLPSMVKFLNLQALSLSYNLISTIKDQTVVPMAAEAFSNLKHLRRLSLSHNALTGSLRTLLESLHQPLQALYLCECKLSSPDLSYLANSRHAKTLQELDLGFNSLKHEALSLEKLLNEAGHTLQYLSLDNTRLNLTGCPVKLWKRLSHRLPTLIALSMRGNDFSPENQVTILKDLAENAHSMVYIGVCMVYEPVIEDDFFMDEWDDVSNDRVTQFFDLYNECKEQEEPEEPTTSNNKTRSVIVHDLDVINKRDALIFIHNLYEEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMX0</accession>
    <name>A0A914AMX0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038064948.1">
        <property type="nucleotide sequence ID" value="XM_038209020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209020.1">
        <property type="protein sequence ID" value="XP_038064948.1"/>
        <property type="gene ID" value="LOC119735322"/>
    </dbReference>
    <dbReference type="GeneID" id="119735322"/>
    <dbReference type="OMA" id="YIIVVEL"/>
    <dbReference type="OrthoDB" id="538607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 24" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037150545" description="receptor protein-tyrosine kinase" evidence="24">
        <location>
            <begin position="25"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="136"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="230"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="340"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="433"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="547"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="830"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="837"/>
            <end position="844"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 22">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="978"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="991"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124051" checksum="07466E7DB2BB9C83" modified="2023-02-22" version="1">MASIVYTCMYIIVVELSCFHGAQGQIVVSGPDWTDTGQDAVFTCISTETVRLVQWSKANFNESANSAILLIGLTVSNGIVVNSNNSKYGFDKDALGYPLTVKAVTSDDQGAYWCLINTLETGYFRNSVEMRVRGPPDAPVITLSSPMIEDAPTTLTCTADMGYPDSLNLVWSNGGSPITGTNTSSSASGDRYSFTSTLDYTPMRQDNGNIITCVAQRDSGMRSSEGRLGPIDVQFCAEAVSVSCPSSTASGSIVQLSCNSGSSNPATSLVWSKNDVDQSNPSQPVFTDGDYGGRETTLRLTTGALTKTDNRAVYKCCVMTSSLCTMYICDSCSLNVEYRPEFSLPTLMPTGPIVKGGSIVLSCSAEANPQPPDFITWEKVGSPDSLTSVYTDGTSTLTLSSISRDQAGSYRCRGNNGVPPVVFSGSVDVIVHYEVSILNKVDTSVGAKDGYDATLVCEGKGNPLPRMTWLRPDGVELTNETDPGRIFQVDTTPEGDDVFGFTIRSTLHINEVTGTGDYGSYTCNSGNGIGMVDTLTIVLNDKVTPLPPEDVSVDQGTVTARSVAITWRPGIDVGEPQWFYVNIREVDTTTGFDPNTRVRITDGVVMHVIESLSPYTKYEIEVYAENANGVSQNVRRTVTTLPDTPEKLDISVTTNQETGIISVDGIPQDGDTLSCLRLEARLTNQDDWFDYGECLESNTDLALREARSRYCYGDLCSQATTAITVAGQSSNAGLIAGIAILAIILLISVALNAVVIMYIKRRGPQPETKKRISIPKFKPEHKGGVTNEAVEYQDLDVPLQILAVGGSPNPAASTYASISETLAEFSREKLTIVRELGQGAFGKVLLGNANGIVQQGTVTQVAIKTLRDDADITERGDLLRELDFMKKLPSHSNVVKLLGFCIDRDPIYIIMEYMSKGQLKELLTSSRGKGKLQVYSNLHGRSKSLTSKDLIKFATDVADGMAFLASQQCIHRDLAARNVLVGENMICKVSDFGLARDVKNMRVYQRKSEARLPVRWMALESVVDDVYTTESDVWSYGILLWEIVTLGARPYPTMSFKTMISKLQEGYRMPRPEHCQDELHQLMLACWEEEPTARPSFTEIGRKLEKLLEGAHDYITLSDYQEFDYEVTIPDSPDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN68</accession>
    <name>A0A914AN68_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064874.1">
        <property type="nucleotide sequence ID" value="XM_038208946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN68"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208946.1">
        <property type="protein sequence ID" value="XP_038064874.1"/>
        <property type="gene ID" value="LOC119735241"/>
    </dbReference>
    <dbReference type="GeneID" id="119735241"/>
    <dbReference type="OMA" id="VTTKHED"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="17041" checksum="6BABE02665373FDF" modified="2023-02-22" version="1">MTTVRILAADRIENSATFSSSQPIPHAVHDMPTPETTKESTPMQRLVKRMTRVFTKLSPDETIKKLTAVLEKMGYSWKTTTARQVTITSLDRRKNPLIFKAHLHEMDDKVLVDFRLSKGDGIEFKRHFLRIKGKLAHITTKVPLLSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANY1</accession>
    <name>A0A914ANY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065318.1">
        <property type="nucleotide sequence ID" value="XM_038209390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209390.1">
        <property type="protein sequence ID" value="XP_038065318.1"/>
        <property type="gene ID" value="LOC119735616"/>
    </dbReference>
    <dbReference type="GeneID" id="119735616"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617297" evidence="14">
        <location>
            <begin position="18"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="270"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="616"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="654"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="715"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="753"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="922" mass="98135" checksum="5A0B5D5C7FA2FC08" modified="2023-02-22" version="1">MVRLFLLVLMLGQAVLSLPYEDRAHSLQEGRDNVRLMELLERALDDLATGENTRDIEGTELSLIGLPAYQSSTLDGSRGSAYAKKVVDGRFDDTKLLGEKGELYGGSCTITNAQENPNWIIRLDKRRCISRVSVLNRGDGDSERLTGAVVRVGNTGVFQMNKNSLCGSPVTAEQAAVPGGTVDFVCDQLPALSDSVIVGIPSPDATLQLCEVRVWELPFERCQRDASLGCTPNPCISAECVPKPDGQAFCECYDGQNGEFCEESSIRIECEPSSDEDRYIYDQYEGYIQSPGYPEPHGIEQRCPYIIGFPGAEKIEIRFEDVDMDFSKSNYLVYQPGDTMDFQSDEKVVLQGLPKESIVVNDDKVSVFFQTSSFNPDNQKGFRMHFKIHIDECASDPCHNAAECVDGVNEFSCTCAPGFTGPLCETDIDECSSSPCQNGVCHDEVNGFSCDCSPGYEGTLCETNMNECGSDPCQNGAECVDGDNEFSCSCAAGFAGPMCETGVDECGSDPCQNGAECVDGINEFSCTCAAGFAGPMCETGVDECGSDPCQNGAECVDGINEFSCTCAAGFTGPMCETGVDECGSDPCQNGAECVDGVNEFACTCAAGFTGPLCETDIDECERDPCQNGAECVDGISEVSCTCAAGFTGTLCETDIDECVSDPCQNGAECADGVNEVSCKCATGFIGPLCETALQEPAKPVQPVTPVEPVEPVIEESNGCTTNPCKNGVCINYGVDGFKCVCSPGYAGTVCEIDIDECSSDPCQNGAECVDGVAKVSCKCAAGYTGRLCEIEQLQGASDARPQLHSTSTGVEVETQTSFMQVNLVTEYCIKKVVVHKRGDCTGARLTGAVVRAGTSSTGLNNGICGSALTAQQAEVRRSTVDFVCDPPLTAKFVTVDIPLLRVTKQQICEVTVEQGTPGPCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP34</accession>
    <name>A0A914AP34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAM234A/B beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065375.1">
        <property type="nucleotide sequence ID" value="XM_038209447.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065376.1">
        <property type="nucleotide sequence ID" value="XM_038209448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065377.1">
        <property type="nucleotide sequence ID" value="XM_038209449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065378.1">
        <property type="nucleotide sequence ID" value="XM_038209450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209447.1">
        <property type="protein sequence ID" value="XP_038065375.1"/>
        <property type="gene ID" value="LOC119735653"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209448.1">
        <property type="protein sequence ID" value="XP_038065376.1"/>
        <property type="gene ID" value="LOC119735653"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209449.1">
        <property type="protein sequence ID" value="XP_038065377.1"/>
        <property type="gene ID" value="LOC119735653"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209450.1">
        <property type="protein sequence ID" value="XP_038065378.1"/>
        <property type="gene ID" value="LOC119735653"/>
    </dbReference>
    <dbReference type="GeneID" id="119735653"/>
    <dbReference type="OMA" id="IKDCIIC"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF36">
        <property type="entry name" value="PROTEIN FAM234A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="7">
        <location>
            <begin position="154"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="795"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="964"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="856"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141283" checksum="D475EDFE26274B95" modified="2023-02-22" version="1">MSRGHRCADADPKMSAEVKWPGFVSFGSMPYDDVYLEDGSSEEDEDEHVLSDSRKPLMSPQKQAKVALRQPPPTVGVHPLIKKRFLRWFYFLLTFMFLGLTVFVLIRIANDAMQQTVGGPTADPKPPTTSEHASEAAREKVILPCSRFDVQDVWVQNFPKLITETAFRLVDVNKDGVLDVIMGFSTGVTSQFADQYLVCDIYFNGSSPCFGGLMALDGQTGRQLWRHYSMYEIFAVNCNVDIDRDGVKDCLGGGRAGIFELVSGATGHLIWTFQNKELLVSISNFYTPQFIRDVDGDGVQDILNIHGGDPLRKRGHKVSHIGIVLIVSGASGHVITWIEVPDQQESYFSPQVYFQHGGREMVLFGSGGETKGGSLWVIAMADLLQGDNSKVTQIYSDSFKGVMTPPALVDITGDGVVDIVMAMFNSTVVAFDGQNYRQLWNYSIPDSETYSSPGVAYYNDDDVADFMVVYNHGPGYPVYYYSQVTILDGRTGQPLLTSPVQTAGSSHVSPLAVSMEGLGNDAFVYFVLDCLGHEAETSSYKFAKDDEEVGIGQLSRSNFCKQRFNTRDFSRLLLLNSHMTPPGEEIYNSLDRVADEYQYKLNSSLLAKAYLDEHPKVLDKVKELALDINHDHEQTGSPHSEERGDQHADGTVHSASRGGTDSVDSDGMQDLDEDDGLDQQDKPTTNKFAPRLGFDDEGEMPFFDPVQPIDDQPNPLPELVDSYERDPQQKYPQQVNSQDVDPLDFDLPDPYLQNPRQPFAESPLGSAPVPGEADVSDSGLSDQLLGDLLNKLLQEEQFGNLEDPPTKNWRGDSGSKGDLPQSFPRAGNSNWQYQSPQRNDQRKKPYFADVYDKDDDTDRREQYDRYDDKRGYADDRGPYSRYDNADREEAKELLDSLYGSSRGDFRSKRYFRMRRDADETPKQGHKPLSLPVEYLNKELFMKYESRDAEAKLLNKLLQERQFGSPGDARRNVYDKDDDTDRREQYDRYDDKRGYADGGGPYSRYDDMRRDADETLKRRRKSPSLPVEYLNNELFLKYESRETEPKELPDGEQSRSQQTANRVGPHRRSANHGQRNARHAGPHDAGGVQRLISTGTLAPVLLGREEIDDHSIDLIFATYWFYPSDTEIILPEQQKCIEEWMAKEAQRMNPKNVFYGLDHDAYEHMATDKCTEGSTRKQKEEYLSRLGPLDIYPFNIHTGEMTVYRLRLTCRCEATSEHQRCAKVLPYSDQRWAGYMGTYGNSHFRPFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR17</accession>
    <name>A0A914AR17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065836.1">
        <property type="nucleotide sequence ID" value="XM_038209908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209908.1">
        <property type="protein sequence ID" value="XP_038065836.1"/>
        <property type="gene ID" value="LOC119735944"/>
    </dbReference>
    <dbReference type="GeneID" id="119735944"/>
    <dbReference type="OMA" id="TIAKECM"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="496" mass="56404" checksum="DBA4427184DB784C" modified="2023-02-22" version="1">MAAYGPQDFVFGDFNFDDFSDFSDLSEGEYDVNIMPDDVDDMDEDDGREFCVCKRVPTKEMIACDGESCSVEWYHYECVGLTAATIPNGEWLCDNCKPCSSSSSTLNNSVEASSSTSEAVSAKAKGKGGKAKSKSKKKETKKTATKTPAATKRPEALYTRDDAVQNATSYFSQSLTSMQNHPMFNLGNSTTVQALLLITQLLMCINEQHVQEYFTSAVSALWLILDTKDGNLLKEEVYMNTWVQYHKLRGTLCTKWEELLQSQGIDSKGKHVYTVFQYLLLSVFQRVIEARNKKDAPEIHEPLTQNSLDKEEEKVLRYVGGYIPFALLKKFRKQKNQTAEVFCKFLASWEVAGSGYAKNFLEYTREWIDTQNRGGLFKISDNVYLYFRAMELVSRVFLTHTNLAKLQGVDIKAVLGNKIFSNHLVQDYWSNVIHEKLSADYSKKLFDVVVNFYVKIRCKAFIKVYLDLKKRNSKAVSKKAEKALRKKLEAEKKPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR71</accession>
    <name>A0A914AR71_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066267.1">
        <property type="nucleotide sequence ID" value="XM_038210339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210339.1">
        <property type="protein sequence ID" value="XP_038066267.1"/>
        <property type="gene ID" value="LOC119736296"/>
    </dbReference>
    <dbReference type="GeneID" id="119736296"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="495" mass="55869" checksum="A2547386DA492035" modified="2023-02-22" version="1">MAVSGIPGNGMYESTTAASSGSLIYAVPDDLIQTVLQHLSATDLCHVASCCRWLRDATNQDSLWLPLCQSKGWKHYGTTTDLAKIPSYGPSEQAGDDSATFQNDRIVTDDNTAGLTSTCRWKGVYMRAHHLDRNWATNCSHFKECHFDLQDKPRTDLRTHSVDGDLLAMYNFNQTIHVYDIRNQTLQCVINSACNLYAIKFTDGVIVVPCDNGRVDAFDARTGQTLQTIEGNWGHNTVSLFFDGELVLTCVHTSDTERTMSTDICVWCVEDGLLQRIITVDHTDDVCVYYTGKLDYRDKMLAAVCNDDHIHVWDARSGECLHQLECPRKQTKVQLGDNVIFGFSTKGDVCVTSIWSQETGDCQKVIDLHVGLPTPYIGEYYTEIINNLILLEIKINVLDVRSSVKTYNLLGEFVNDAQLEYNDGDVKGNGSKRLFNLFVETRMGREDWKGVVFNATPTGLVRLFDAGPFEIIWLDEIRMILFDHKENKLSIHHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATN8</accession>
    <name>A0A914ATN8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067420.1">
        <property type="nucleotide sequence ID" value="XM_038211492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATN8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211492.1">
        <property type="protein sequence ID" value="XP_038067420.1"/>
        <property type="gene ID" value="LOC119737278"/>
    </dbReference>
    <dbReference type="GeneID" id="119737278"/>
    <dbReference type="OMA" id="IHMTIAG"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="30798" checksum="911F7E93DDDDDFDC" modified="2023-02-22" version="1">MASSKPTKVNVTRQKSPARKTPGELVRKPSSSALRNSQADRKTSVAASRKVSVASSSSSGRKVSVSSKTRGPGTLSRKTSSVSDRFSGYTGQPPSVLYRPPAASSSVVGFRQLLVTKRLARNLKLRTTQRMAERRGRSFITYSDRPRRRHLSPHQDVLLEPSYQVYPQQKFGEFRGTISGILEQMIPETLARMPYDARVCSRQAKALAGDIQERVKDLGIERYKLITVVHIGEIQQQSIRVCSRGIWDVEVDSSVTYQYQNASLYCVATVFGIYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVB7</accession>
    <name>A0A914AVB7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067434.1">
        <property type="nucleotide sequence ID" value="XM_038211506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211506.1">
        <property type="protein sequence ID" value="XP_038067434.1"/>
        <property type="gene ID" value="LOC119737286"/>
    </dbReference>
    <dbReference type="GeneID" id="119737286"/>
    <dbReference type="OMA" id="THHNHER"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="143"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="402"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="573" mass="62809" checksum="A029F40CF33D9B84" modified="2023-02-22" version="1">MAHVAAGFLTVSKHRFSIVESAGPLFPDMSRFHRYRVWRAASVVHLYFSLSCLALVAALALLALGIEDLDYRLHGDIPDHRVSRRDTDGENAAASPLDLAAIHDKNVSPALDVNCTPPSIDNFPPNLMSWEVLRHGGFLINLAAVFYMFGILALVCDNYFMSSLEILCADLHLSEDVAGASFMAIGGSAPELFTSIFGVFIAKGNIGVGTVIGSAVFNILCVIGLCGVLAGQIVYLSRWPLARDFLWYVLTVIGLVLVIWDNVVHWWESMIFIIVYIAYLIFLYFDPPIKRYMESYSGCQTDHDREGDDVTSSDLTSSGAETTPIVVDQKLQTSSFGADDNDNSGKTAPDEKLQETEVNPLSPFLIPDGCCKRFLWFVGFPPSFLFYLTIPNCSLKRWRKWYPVTFVVALAWIGAVTYLLVWMVTILGYAFHVPDSVMGLTLVAAGSSTPDTILSVIAARNGYGDMAICHSIGSNIFDILLGLGLPWFLHSAAVQQGQPVPTYSDGLTIIAAMLLATVVVSLIIIKLSSFKLNKKIGVVLIVFYVAFLIPAILLEMNVLVKGLTLPQCPRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXB7</accession>
    <name>A0A914AXB7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068780.1">
        <property type="nucleotide sequence ID" value="XM_038212852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212852.1">
        <property type="protein sequence ID" value="XP_038068780.1"/>
        <property type="gene ID" value="LOC119738111"/>
    </dbReference>
    <dbReference type="GeneID" id="119738111"/>
    <dbReference type="OMA" id="WRLRWIE"/>
    <dbReference type="OrthoDB" id="191769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02522">
        <property type="entry name" value="GT_2_like_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/seldom-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="SLL1095 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="259"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="502" mass="56040" checksum="31CECB959A7F2FBD" modified="2023-02-22" version="1">MWLILLLICFLVIFATLWYLRVVSKTSSKERIVILCKFPRPGGVKTRLIPGLGEAGAARAQLYMSDHMLDVLSEFQRQRVGITVEVKAFGGSADQFKYWLGRKLFPRQCFSWSFQCDGHLGIKMADALNSAFNEGSEFAVLIGSDTPAVNADILETALSKLRSPDCEMILGRAQDGGYYLVGFRRQVKERLGVLNDIFEGIEWSTSTVCHRQAEIATGLGVKVQLMPQILQDVDTPDDLPEFEKSVGVSVTALKAPVLSIVIPTLNEEENIERALRSIKENSSWIDYIEVIISDGGSTDSTLGKVDEFAQNNPELRIKTVRGGRGRGKQLNAGASEATGVNLLFLHADGSLPLAFDRHILLTLAEPGNIAGAFNLGWDVLQGDKRNDCSRLISAQLQLGQLLHLACYKFTETAYGDQGMFMSRKIFEKVGHFPPYRLMEDYEMALKLQRYGHLKILQEVFIIASARRLIKKGVWKARFINCLMVMGYHMGIHPDTLANFYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXH6</accession>
    <name>A0A914AXH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068393.1">
        <property type="nucleotide sequence ID" value="XM_038212465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212465.1">
        <property type="protein sequence ID" value="XP_038068393.1"/>
        <property type="gene ID" value="LOC119737842"/>
    </dbReference>
    <dbReference type="GeneID" id="119737842"/>
    <dbReference type="OMA" id="PPDAHFW"/>
    <dbReference type="OrthoDB" id="10041077at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="38052" checksum="67EE5F9D036A5B18" modified="2023-02-22" version="1">MGCCFRKRQVEGAAELTERDTAKTGGTSGQVKKSGLQFQEIVDGEVYLPHQHKPDEAVHFGVRLDDVDGQHVLSETVENSLARDAGIHDGDVLVDINGTNIEGRQVQYLLDLLREEVKHRLLLTVKRQLDEDKHVFVWTYFKVVVKENQPEVNILYLTQTDEDVMPWINVDPSQPAEYEWVGPPIGSYDIYIDETTSHYLSLSNNNNRGTVEFVSKHNPLTCTFYKYIFVGPGEPENGIVVVYSLQKYEQSVTVDALTTPEAKANSDADPTIGVTDFPLPKTGTTIPVDPRFWYQKENADNGLFSLQSVEQNGWYVSKSTSGDDATLSKTAQYFKIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYL9</accession>
    <name>A0A914AYL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038068797.1">
        <property type="nucleotide sequence ID" value="XM_038212869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212869.1">
        <property type="protein sequence ID" value="XP_038068797.1"/>
        <property type="gene ID" value="LOC119738127"/>
    </dbReference>
    <dbReference type="GeneID" id="119738127"/>
    <dbReference type="OMA" id="HETCERW"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161128" description="Metalloendopeptidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="16">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="807"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="878" mass="100054" checksum="93FAB1209D863813" modified="2023-02-22" version="1">MKMMEAHHFVWLLLPALCAASTASESGVIVGPPAPQTMDAGPDAMETIIEQNEPLFEDMAEGTKSHFIVDSDIYDPTANQTRKRRNAITDRRRLWPGGIVPYMIDGYFTNDQRLYILSAMQRFHEKTCIQFRPRTIERDYIVITEGEGCWSMIGRRGGRQTVSIGGTCKNSRGTIIHELMHALGFRHEHNRPDRDNYVVMYWQNIDKKMWDNFAKYSRRDVTLLDTGYDYLSLMHYPTYAFSKNGGQTIGTIYPTYEEPGTRNDFSYVDVYRITALYRCGACYDTDKDNCPTWAIMDECRRSSVWMQKYCPFSCESCNKADYAGGDCRDYSNSCEKWSSQDECDRNPDFMGYNCKLSCGYCKAPNDIHSRRECYDDSTLCTEWAQMGECYNNPEYMKKTCRKSCAVCIETDRDHNVGDGDCRDLHPLCHIWARHGVCQSYEEWMLVNCALSCWRCANKTGVTVEIWGDTTADGSGTPKPPPRRRQICQNKHKRCDQWAENGRCTREPDFMYKRCLKSCGMCIDERVTGVKAPTTKRRQCTDRFTTCKLWAGNGECGIANEWMQKNCQKSCDACPEEAELHPDCSDSYLRCSAWAAKGDCQNNPGWMNVYCRKSCQRCHEPKVVPGCMDQQRHCKRLADGGGCQGENSRWMRSNCPLSCGFCGVYDRAPLPPPPTVNASASPAHYNTTGGECRDFHPHCQRWFENGNCHVNVRYMKNHCRKSCGYCPTCFDKDASCRTWAKRGDCLFNPKGLAKACAMSCGNCGDGPAECSDIHKQCAKWAKRGYCEENPTFMHKFCKVSCNTCDPNDQTASQEPATEEVEGVGRPQKKPKKKASTKNKRRPTTSATNRPRKIATRHRKKNKKQRKTNAQGRVADVPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZF1</accession>
    <name>A0A914AZF1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Solute-binding protein family 3/N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069048.1">
        <property type="nucleotide sequence ID" value="XM_038213120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213120.1">
        <property type="protein sequence ID" value="XP_038069048.1"/>
        <property type="gene ID" value="LOC119738282"/>
    </dbReference>
    <dbReference type="GeneID" id="119738282"/>
    <dbReference type="OMA" id="DACTGWS"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936:SF19">
        <property type="entry name" value="AMINO-ACID-BINDING PROTEIN YXEM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="37248" checksum="C572881C7513ABD2" modified="2023-02-22" version="1">MTQSDEADLTSQKAGKGVIRDNMSTGREMLCLTVAVLIVAVLAILAVILAAISLGRPNTPVNTTVQIPNGGGAVSGAYLGVAPVPEDQDPNKIWVFAIGHDGTNLEYIDDLTGTVRGFHVDIIEAVCNFGNKNCRLMWDVYENCYTQMPNQRPRVGVGLVSRWYDACTGWFATYERIASVSFSKPFRQPLSAVFFVKRGNPQAFSSTDLTGKKIAFIDGHASNIFCVRRAGITGVDRTAMIVHYSTREEIIAGVNGGEVDAVFANDQIFNLRTDLDVAAGNPITTCMQAGAGMMVRKDSRLPNWWDPAFDQLKQTSQYRQICDEITTNHDQSDHEVECVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0I8</accession>
    <name>A0A914B0I8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069910.1">
        <property type="nucleotide sequence ID" value="XM_038213982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213982.1">
        <property type="protein sequence ID" value="XP_038069910.1"/>
        <property type="gene ID" value="LOC119739151"/>
    </dbReference>
    <dbReference type="GeneID" id="119739151"/>
    <dbReference type="OMA" id="QNPFYEP"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="138" mass="15916" checksum="BEF225C1D8FDF747" modified="2023-02-22" version="1">MAVCVAVIAKENYPLYITTXPTENELKFHYTVHTCLDVIEXKVSAVGKSVNDPRELYLGLLYPTEDYKVYGYVTNTKVKFVIVVESSNMQLRDNEIRNMFKTLHNAYVDMLCNPFYTPGENIKSKTFDNTVMQMMVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0Y5</accession>
    <name>A0A914B0Y5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069439.1">
        <property type="nucleotide sequence ID" value="XM_038213511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0Y5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213511.1">
        <property type="protein sequence ID" value="XP_038069439.1"/>
        <property type="gene ID" value="LOC119738605"/>
    </dbReference>
    <dbReference type="GeneID" id="119738605"/>
    <dbReference type="OMA" id="AKTRIYK"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="755"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="843"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="911"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126108" checksum="8B0AED73915A48F7" modified="2023-02-22" version="1">MDRATRRKLLESKKEELSEAIDAEKVARELLARDGISEDIRDLILKQRSNKDKTSKLVDVMKIAKNSKYEMFCEVLREHGHDKLAQQLMKQEERSTAKRKTKTGAGEAKRKSSSTKADSYADVFKSCRNCFISDVAADPNRLVQQLETGAGKGVALSSATKRQVELEAEAEAKAEILFEAILPQINEYGPFFEMVQILREPYQHLSNQLWEQLKNIVVPPPKSGANVNRNKQSAGSSHSSLPASPGSLRSAPQSAGKGPSNDIMKSLTNLQSDLTESQSDSLKQSLQLERCIQTTAEANNSIKKLKVQLRLSEEERDAAASQADAARQQAAEARQLLETGLAEADAERKKLEDQHRKWEGQIRRRMSILEQKETYLASKEVELRRREEEQKQRNQLQRRQHESLEKKGLDMSNRGERQDMRSAEYHVRQDRMKERENNLEMNESQLSEREEEVARKESILKKKDIDLRRKEIETIRLEEQIKMMQASQRKMATQLKQKEQSVAQAEEDVKIIGDNLQQREESLREKERRLNMKMLQVKETEEDLEQLKSRVEKKERQVQEAEAEMREWEAELENKSQELSNMTSGAEIKEEELRQKEEEVNFKKKELDSLQDVLDCRLQAQERMERALRMIEVEQIRRDKEILNREAEYFHFNFPSQKKLEEMAGRMEELDKKDGELKKREELLSWIEVEQQRREVELKKQQLLAERARREAEAVDDEEAVGDNDDQRTEVDSVPLSDAISLPLEADPEPEMFGYEVMLKGARYAKRGSKSSFEMKVAGIQTVAAFKNILETEEGVPATWQSVYLNGQHLDDSMTLPSSGTPGGLQKIELKLNTPQLKERDIIKLKVRSCNGPTHTIEFSQDDTVALAKARIYKYTAIPPHQQLLSYKEVLLENHAPLQLYSIRKNATMDLRLRFSVIAEMSSSQQMTITADEINTIANIKANIFEKTKLPLDNLKISYRGKQLEDHRTLAHYNIEEGAVLHVSCALNVKMHATNTDINLDVEPGATVQQLKQILSRRKNINADRMYIVTGDQILNDDQDVTEVVRHGKDLGMHVGNVLVMSSSGQIMRNGGDNEGQQTGNQTDRSLDLSVSGSLNLSQIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B260</accession>
    <name>A0A914B260_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphatidylinositol-4,5-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.78</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25674"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Late endosome membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 11">Lysosome membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.78" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_038070435.1">
        <property type="nucleotide sequence ID" value="XM_038214507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B260"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214507.1">
        <property type="protein sequence ID" value="XP_038070435.1"/>
        <property type="gene ID" value="LOC119739532"/>
    </dbReference>
    <dbReference type="GeneID" id="119739532"/>
    <dbReference type="OMA" id="ASNHGGM"/>
    <dbReference type="OrthoDB" id="9939933at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034597">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019178">
        <property type="entry name" value="PtdIns-P2-Ptase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014:SF6">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09788">
        <property type="entry name" value="Tmemb_55A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="270" mass="29000" checksum="D306D3C1A58A804B" modified="2023-02-22" version="1">MADSRRGESEPLLSNSESSENEGIAPSAPNLPPINSTEIPPVLGSDVPPPIQPGEMPPPYSPPVQGGPGGGVPMINCRVCQAMINLEGRMHQHVVKCSICHEATPIKEAPAGKKYVRCPCNCLLICKLSSKRIACPRANCKRIINLAPMTTVATPSTTNTLTTTSGYRVVCGHCNERFRFPHSSTLARCPYCRRVSSVGQAYAKNRCIIYTVIGLIFLGAGIGVTIGTYSLAENQGGIYFVWIGAFVVGILNLMRAVYYGVMKVSTLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2S2</accession>
    <name>A0A914B2S2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069801.1">
        <property type="nucleotide sequence ID" value="XM_038213873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2S2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213873.1">
        <property type="protein sequence ID" value="XP_038069801.1"/>
        <property type="gene ID" value="LOC119739038"/>
    </dbReference>
    <dbReference type="GeneID" id="119739038"/>
    <dbReference type="OMA" id="GQTMELY"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF14">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22208" checksum="4F3CC162184FCB70" modified="2023-02-22" version="1">MKSMTGEKGTTSAKLASFLLAYRNAPHSTTGQSPATLFMGRNLRSRLDILKPNIRNHVSSKQVDQATSHKSASVTREFHIGQTVSVRDYRGKQKWIPGVIHARSGPLSYQVCVGPNMIWCRHVDQLIDSDTGKPPDLNTPHDAVPEILQPDPVIPASLTATPEQAVPSETLTPAEPPLPASPKVVERRYPSRNRKPPDKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2W6</accession>
    <name>A0A914B2W6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069841.1">
        <property type="nucleotide sequence ID" value="XM_038213913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213913.1">
        <property type="protein sequence ID" value="XP_038069841.1"/>
        <property type="gene ID" value="LOC119739078"/>
    </dbReference>
    <dbReference type="GeneID" id="119739078"/>
    <dbReference type="OrthoDB" id="6102375at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="269" mass="29799" checksum="ADC656983B174329" modified="2023-02-22" version="1">MLKEVNRLHWRLGSVGDMCLLFLATQLCCFQYVHCGFRAISLSGKPTSQSSTTSSLYPSFKAIDGTASSFSHTAGGDPHPWWKIDLQNERCLGQITVQIRSGCCGQNRFFGTVVRAGLSTNYTENRPCGSPATAAQSSPGTVTEFPCDTPRRARYVSLDIDPSRPGVTTPILQIAELTVEEHTTRPCYPHIKSTKFERLHKKGLIDNPNPLSTKTARSLTTCADFCTKETDCFSFDFGKSLKQCRLYNLNSTDIVMTPNDEFAVYTVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3D2</accession>
    <name>A0A914B3D2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type I cytokine receptor family. Type 3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070428.1">
        <property type="nucleotide sequence ID" value="XM_038214500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3D2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214500.1">
        <property type="protein sequence ID" value="XP_038070428.1"/>
        <property type="gene ID" value="LOC119739523"/>
    </dbReference>
    <dbReference type="GeneID" id="119739523"/>
    <dbReference type="OMA" id="PEHITGR"/>
    <dbReference type="OrthoDB" id="10005435at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF151">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037435119" evidence="7">
        <location>
            <begin position="29"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="227"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="339"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="445"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="578" mass="64891" checksum="6833A81A0278C521" modified="2023-02-22" version="1">MSLLLPTLAVAQLVALVIILCRTNEVAAIPASIKPMDPTVVVGSNVTFRCVLNTSATTQTATDIVWYYKSYRSLIPRERYEVEDNISRLTVRNVTFTDSGSYFCALESDGRRIWNYQGSMLRVGVPPSPPTGLRCHSPNMQDFWCEWSEGAKTNLRTHYKFSYRERYGSGDWKDCPKLEGRGQNTCVVSRVHNDGYNQMIRVTATNNLGSATSEMHFNPGTAAIPNPPTAVEVEALGPEELRVSWGFPSEWDDQVFAFFLEYRLEVTTDRGSHTRMIPDLSHSEPYVKPRLYTINNLLPHTSYSVRVSCRALGSYSDDKWSAWSEPVSRKTSEAAPNAAISGIQGQEYDNINDPAYRRDVFLQWKELSHANRRGKILGYEVELRQMLPNGSSSVVRTVRANGTMVLIENLEKFKEFYVDLAAFNSAGRGPTGSYFLADKTSEPGPPENVRVQNISETSALVTWQRPTRPNGYIEGYHLEWNKGAVAETTSNFIELNGTQTSYTIKGLEANRLYQFRVKAKNSRGYSGWSNAPIQHMGSGSRMELLRTLITVLHNLLMDMGDEGEAGNQIKLDTLSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3K3</accession>
    <name>A0A914B3K3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070081.1">
        <property type="nucleotide sequence ID" value="XM_038214153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3K3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214153.1">
        <property type="protein sequence ID" value="XP_038070081.1"/>
        <property type="gene ID" value="LOC119739278"/>
    </dbReference>
    <dbReference type="GeneID" id="119739278"/>
    <dbReference type="OMA" id="YRGRATY"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12550">
        <property type="entry name" value="RRM_II_PABPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000311">
        <property type="entry name" value="polyadenylate-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="25322" checksum="679ACB3F3A686EAB" modified="2023-02-22" version="1">MADYLDDQTEDALLAGPDEETSPGMPGFQSPGGDETGVEDAELEAIKARVREMEEEAEKLKEMQSEVEKQMNMSSPPPAGPAAPLSLEDKQEVDNRSVYVGNVDYSTTAEELEEHFHGCGSINRVTILCDKFTGHPKGFAYVEFSDKDMVEPALALNESLFKGRQIKVSAKRTNRPGISTTDRPGRARFRATGRSAYRGYSPYANVYGGYRPRRYRPRRYTRYSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4M8</accession>
    <name>A0A914B4M8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071226.1">
        <property type="nucleotide sequence ID" value="XM_038215298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4M8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215298.1">
        <property type="protein sequence ID" value="XP_038071226.1"/>
        <property type="gene ID" value="LOC119740096"/>
    </dbReference>
    <dbReference type="GeneID" id="119740096"/>
    <dbReference type="OMA" id="EVLICAY"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="425"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="684" mass="78802" checksum="DEBEDB8ACC6150E5" modified="2023-02-22" version="1">MDVSSQIKALLPEVINGKTLKELEEETTANDKKYAHFVKGVKLPYVVPLSTIEALKTFEVRDDDVCVVTYPRSGTHWIAEIVSFILNEGRDDFDRTFMKCNLEVTYTPDPSKVESTIPGYKKFEEVNSPRCINSHLPYSLLLPDVVKKSKVVYLARNPKDTLVSYFKLTKPSMPPTFQDFSVFLWLYYAGEMIFGSWFDHVLGYWRQKDHPNILFMKYEDLHKDLKGSIRTVAKHVGKDLSDDVIDHITERVTFGGMKSTYDKFTDVYGEAEALQMTNMFGEDTVFLRKGKVGNWKNTFTEEQSALFDKIYALRMDGTELEFDFDLQYRTAIFNGCVSTLGYCGEVVYLWLYPSVHSVRSVAMNVAEQIQALMPDLINGKTHQQLEEELAAGDKQMGCHVVNGIKFSFTLQQSNLEALKTFEVRDDDVYIFTYPRSGTHWVGEIVQYILHDGKADFDRTFMTNGLELTIANGPTEVESVTPGYKTYAAMASPRCILSHCLESFRPPQILTKQAKMVYVARNPKDMIVSWFNIFKIASHWTFNEVFWAFCLEKMNYGSWFDHVLGYWNQRNDENLLFIKYEDLHKDLRGSICKLAKHLGKDLPDDVIDDILERVTFGGMQKSYQQLEEERGEEGRRMTRRRGIPHLRKGQVGDWKNTFTVAQSALFDKIYALKMKGTGLDFDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4R3</accession>
    <name>A0A914B4R3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071256.1">
        <property type="nucleotide sequence ID" value="XM_038215328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4R3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215328.1">
        <property type="protein sequence ID" value="XP_038071256.1"/>
        <property type="gene ID" value="LOC119740122"/>
    </dbReference>
    <dbReference type="GeneID" id="119740122"/>
    <dbReference type="OMA" id="AEMIWIN"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="393"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="517" mass="57767" checksum="370F4D84BCC55957" modified="2023-02-22" version="1">MISHYATSDELSDKARFPNFLRTIPPDKLQARAMVDILEKFGWTCIGVLYTSDAYGIRGSQELLKLADEKEMCVVFSKSVTGSKPTQSEIAELLSKIDEFEIVHVIIIFGGEEMYDILEELECRKPGYRVTLICSDGIHGRKLSEVYLGNMTKGSLRLEQHRSYVPEFQDYFKSLEAASQVSPWYNELKDFIMKSNECVNLTLCSLPQYAMIESTIYHAVYAFAYALDDLIRQRCSSRTTDCSHRLHNISGQDLLPYLFNVQFEGVGGPFEFDANGNAEGAYTIKGLLEENNKIEWQDVGLWDSHRTQKLSMVDAAILWPDGTPQSHCKQECLPGQIAVPLQEKCSWGCQTCYKDAIVVDNACEQCKRTHWPSTNRSACEPIVPASVATYEVIIVVILVLCSTGIALAGLSFAGLCYYRHHSLIKASSRELGTVSIVGTISACLVPLPLLLPPSDHTCAAAEALVSLCFTMTYAPTLLKVNRIHRVFQAGRRSTKCPRLARPKEQIFIASIIVLIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4Z4</accession>
    <name>A0A914B4Z4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071143.1">
        <property type="nucleotide sequence ID" value="XM_038215215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4Z4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215215.1">
        <property type="protein sequence ID" value="XP_038071143.1"/>
        <property type="gene ID" value="LOC119740023"/>
    </dbReference>
    <dbReference type="GeneID" id="119740023"/>
    <dbReference type="OMA" id="WIMEITF"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="320" mass="37101" checksum="A465FB42B28BA628" modified="2023-02-22" version="1">MSITEQIQALMPDLVNGKTLQQLEEELAATDKQMGCHVVNGRKFPGFIPQSNLEALRTFEVRDDDVYVFTYPRSGTHWMSEILHYILHDGKGDFNRSFMTNVLEMTMAEDPSQLESVTPGYKMYAAMASPRCILSHCLESFRPPQILTKQAKVVYVARNPKDMLVSLFNMASHWHFDEVFWAFCHGKMVMGCWFEHVLSYWNQRDKENFLFVKYEDLHKDLRGSICKLAQHVGKDLPDDVIDDILERVTFGGMQKTYQQIEEERGEKGKRMTRYRGVVPYLRQGQVGNWKNTFTVAQSALFDKIYALKMEGTGLDFDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5Y1</accession>
    <name>A0A914B5Y1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071513.1">
        <property type="nucleotide sequence ID" value="XM_038215585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5Y1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215585.1">
        <property type="protein sequence ID" value="XP_038071513.1"/>
        <property type="gene ID" value="LOC119740315"/>
    </dbReference>
    <dbReference type="GeneID" id="119740315"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00182">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF207">
        <property type="entry name" value="OVER COMPENSATING MALES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="223"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="728" mass="79164" checksum="70D7937A2DF434C1" modified="2023-02-22" version="1">MELSQNAKAFSIQSLIATSSEIDKDDRDRRQTAEIYSHSSGLKPLGTGSVDTESYNGGPAGPSESTLSDSTDKSLVHRTASLLRGISMHDDVEGGLAGAHPPSSPPVARQGFPLTNLNIVGQRSVRPKVRCTGDLYPDEGISGSGSKQKAGIGWYPDESHGRPLERRFLLGADYMLTDPPCPVQHPSIKDVDPTPGKDGMESVDMETADQPISKCVDGIQVTLENSKLWKMFNKCGTEMIVNRIGRRMFPCVVITMLGMDPTTLYRVQMELDASDRRRYKFINGKWVPVGKADAEPPNKLFEHPDSPSLGAFWMQDRVSFAKLKITNNKETGGTNTVLHSMHRYTPRIIITQLRCSSANVRGIAAPCSDPNLPTEGGVPHYRQLPAAVGGSRPSCFEFEETAFIAVTAYHSEQITQLKIQNNPFAKAFRDADIASILQNSYVHSEPNESTIPPTCRGVSMRMAVLSQGMKPVGPNVAEYYPPVERRPLLARRTIRVPKFPAAPWSFDTRALARRLRPSGTYAHAADRNADAMRQSRGPSQEASSQHGGASGRLPAGQRRPKIVSSGDKSGASFHVQADATNRSATTSKFSEFRQAVSDNLHPLRRVSSTAVTRAVKRHSLPYFSSKKVVYIPRYGSADNATFEKSHDQHELVPRRHSIVEGLPKFFRASTGNLRSKMEAEQPAICGPPVVLSPTSKMAGLAASSGDCMSASTSTVASADTTACASSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7F6</accession>
    <name>A0A914B7F6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072098.1">
        <property type="nucleotide sequence ID" value="XM_038216170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7F6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216170.1">
        <property type="protein sequence ID" value="XP_038072098.1"/>
        <property type="gene ID" value="LOC119740760"/>
    </dbReference>
    <dbReference type="GeneID" id="119740760"/>
    <dbReference type="OMA" id="KFVRGWN"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043556">
        <property type="entry name" value="StARD5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374">
        <property type="entry name" value="PROTEIN CBG07384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="266" mass="29360" checksum="BDD940A2D4959985" modified="2023-02-22" version="1">MLRYLAPVTLGVCAVSAGILSGKPAASRISVSSAVRRLLVAANCHAGGTGISSFGSMDYKEEAERMSQRVFELYSDSDWKVAKTSKDIRVLYKKSAEFDGYVYRAECTLDSSPERILEYILPSPKGLRGKWDKNVKESEVIEHINKDLIVARSATHSAAMGLISSRDFLDLIYVKRYPTNNMVCTHSKSIKRKDCASRDGFIRGTNYHGGTFCIPVEGESTRTRVINMVQSDLGGMLPKTLVDSALPSNLIDFFVDLDNALKSNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B895</accession>
    <name>A0A914B895_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072393.1">
        <property type="nucleotide sequence ID" value="XM_038216465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B895"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216465.1">
        <property type="protein sequence ID" value="XP_038072393.1"/>
        <property type="gene ID" value="LOC119740932"/>
    </dbReference>
    <dbReference type="GeneID" id="119740932"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000010">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="509" mass="53640" checksum="4AD3D9A9461921AD" modified="2023-02-22" version="1">MEFQNTTEAGPAQPSTGGDDALAGIQSSLNSLQVNADTFFLIVMACLIFFMQCGFAFLEAGSVRSKNTTNILIKNVLDVCIGACAYWAVGYAFAFGPGNAFLGHRYFFFESMPPSLYSHWFFHFVFAATATTIVSGAMAERTEFGAYLIYSCFITGVVYPIVSHWAWSGEGWLAAGPGIEGVAYQDFAGSGVVHMVGGMAALMGAAIVGPRLGRFDKKGNPTTIPGHTVPFAALGGFILFFGFFAFNGGSQASISQPGDGEVVAISIVNTIISGGHAALVAMVIKKLGFNGQWSLLITINGALTGMVAICAGCNALAPWGAAIVGIVSGAVYVFWSWLVCKLKIDDPLDAVAVHLGGGLWGVFSVPLLSFETGVVFTWSQVAFTSFGWNILGAVAIMFWTGILTAVLFGLMRLFGILRVSPEIEEKGLDIAKHGEPAYPLSSYGHGWSSEANLIEVKVDGDGSTAESLNSSFVKDGCHGVLPAQVIHASLSEQESVENGVATVAEEANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B904</accession>
    <name>A0A914B904_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072658.1">
        <property type="nucleotide sequence ID" value="XM_038216730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B904"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216730.1">
        <property type="protein sequence ID" value="XP_038072658.1"/>
        <property type="gene ID" value="LOC119741076"/>
    </dbReference>
    <dbReference type="GeneID" id="119741076"/>
    <dbReference type="OMA" id="MIEDTDM"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="90" mass="10291" checksum="06ED679A5480D581" modified="2023-02-22" version="1">MADSSKAVIKNADMSEDMQQDATNCAVQALEKFNVEKDIAAYVKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQTAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9N1</accession>
    <name>A0A914B9N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear pore complex protein Nup133</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072152.1">
        <property type="nucleotide sequence ID" value="XM_038216224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216224.1">
        <property type="protein sequence ID" value="XP_038072152.1"/>
        <property type="gene ID" value="LOC119740797"/>
    </dbReference>
    <dbReference type="GeneID" id="119740797"/>
    <dbReference type="CTD" id="55746"/>
    <dbReference type="OMA" id="TRKYEEY"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="830"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127380" checksum="F01205C8C7C2B6D5" modified="2023-02-22" version="1">MYTPRTGGSKGKYTPFSTGRIGSSASSRRSSAGIFGSSSGARRSPFPAYSGAGTRSPAVGNRSFLQTSVIAETAQYTVENYGPSVPVLISEALAMADRSVSMSVRIDPSGWACVVCGRRLFVWRYKNTFARATFCKELALPPSELSHKAELVCLIPASPDNQTVAVMAASPEGIIRYWPSIASEGAYSESSAELNGEECFSLTQFEPYGCILATTTNQLLLLNLADSNTQNTVSCHPLKPSQGVLARVSSLFFGSQRPQSSSTLQRVLSAGQEDGQGVVYVLQEDILQKWLVAEPGAEKVVFEVQLGNMIKKGFARQSACSSIDSLRVWMLDLQIVSESALLLLVAATDTSRPSPVVHYALVLIPLVSASGAGPDQISAFKMLSLTAPYQVSEEESLLDYRLLVASPSNMACHVYSRNMVICCSGITESSCSFDNVDFSQPGNSILGAGSCDGTTLFFSTNYGLVTVTATQQEPSFLQDVSLAEQSLRLDQSSIISSPAPPQDISSLGEDKTKGLKAAFLHACRQNLSQAEAIVEELFPTSAPSPMETGSPMDAAVAKLSQEVIDDFPASDPRWAESIPQDTASSTTSLILLHQLEDKMKAHDHLLSFLKNVGIWDRLHSVVVRESPLSTHLLLCEHAEKLAAAMALRSHHTMYPNLADGAISKVLQKRGQTHTPAGLTPQDVFYREVSGIHEIIENLVEQEKDILSTELTSSDTVSVINNVNTIIQGMLKEAWHLRQSKALVYQSLSRNVSKPTLQYIPWTASTGPKGIRSLLVQQHRVTIEQGIPNGEDIQSRGALYQQIMELTDLILEGYVTQLESIGLGSGEDSSQYEELEQKYQQERHVLIMPLLEQGQYERAASLAEKYCDFGILVSLCEVTDNEERLQRYMNQFATKGFSDFVFKYYMDEGKRGKLLSQPFSQHAELSEFLQAHDHLSWLHDVQVKDYIKAQGTLKRLSAKETLSLAKKKTLLSLSKLTALACDEVPEAELEDINSELDVILHQEQLPKELVQKMELFNSEGDLPVIDPEQLIWLYISEKNTDANEFDFKKALDLLQYLPKDDDAKIDHLRLNVWCKAILKDDWSADRGTGVDPLEHYEDTVFFRTARLILESGADLEYYLPDVDALLTSDELKPLQGNANFQFILRAGYEQMERIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9Q4</accession>
    <name>A0A914B9Q4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072831.1">
        <property type="nucleotide sequence ID" value="XM_038216903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9Q4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216903.1">
        <property type="protein sequence ID" value="XP_038072831.1"/>
        <property type="gene ID" value="LOC119741187"/>
    </dbReference>
    <dbReference type="GeneID" id="119741187"/>
    <dbReference type="CTD" id="51542"/>
    <dbReference type="OMA" id="FSFVQSY"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118468" checksum="A9FD45000E9EDF81" modified="2023-02-22" version="1">MSGWESRSQSLQSKPTKLNQVHHAQQHGSRASTSTAGNRHVTRSHHQNRHERTGSNSEFGFPKTRTNPNSTSGQVPNWKSCRFCALTFKNPADFCLHLREYHCTKEGGSFVCRYGLNGVCTTLPLEGVSDGDYESHVAKDHSLVSVNDAIKKSPNGSSSDEPASSVPSVVNDQHKWTIYCSQVSLPAVLNDPRKAKRELDFLTKTWGETFVERNDILPSPHLPHITRAHFEKYLRWTGTRLKEHKKLDLAISTATVDPSDNHQSPVVRLKERGSTEVEQIPKMFFRNDFALENPDTFEAVLPWSQFRGQRLSDPASGHQSSKLLQEKLSHYLDIVEVQIAQQISIRSNAFFSAMASHDKLQENLASTCRAIRELRDKINNIDAILAQGNLRLLKLQISRANYVKVFNKLKLMATVHQTQPTIQILLTTSEFVGALDLISTTQEVLTQELSGLQSFRHLGSQLVELEKLIDKMMTQDFARFTAADLNRPLDGQGHVDEDKLTAIILGMLRQHRFSFLETYREEAAESIKALIKQTVVQAVSTADNMDNDANIGSLADQMRLLNFPQWLQLFRAVFENLGLLMNRVKETTTVIKRLVDLAAGVDPDSHTEPVVTGPDQNGLVECADEATALDEGEQDDEPQPRPSKVEEMMPTTAAKLDVDVLIAPIEHNRLTQSLQDLLLFVCDYAHDRCLKLLIARGKDGFLERLSSGEFVSLSRAIEKFVGKCESVCERRSTSLRGGLQNQANKFISRFHEERKTKLSLILDSERWKQAEVPAEFQDLLSAMAKGEISLTLLVNADKGSGERKPLELVEIANQRYSVVGTVLLLLKMVAEYCQCAIDIPSVTSDILTRLVEILQMFNSRSCQLILGAGALQVVGLKTITTKNLALTSRCLQLVILFIPVVKDFFSQKLPSKMQGLLKNLDKILKDYNDHVQEISNKLVNIMDDSFRHLLSTWEVKAPVPSACFREVCKRVRKLHEAIAELLPPEQIKVLFMRLNVSFKTHLRDALIRVKVRNDGGPKHGLVTSDLAFYTEFIQSLDGLDSVVDNMDDVWDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB62</accession>
    <name>A0A914BB62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073080.1">
        <property type="nucleotide sequence ID" value="XM_038217152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217152.1">
        <property type="protein sequence ID" value="XP_038073080.1"/>
        <property type="gene ID" value="LOC119741407"/>
    </dbReference>
    <dbReference type="GeneID" id="119741407"/>
    <dbReference type="OMA" id="SPIGRDW"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="3">
        <location>
            <begin position="173"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="700" mass="78852" checksum="CCDBFB053E4C84FA" modified="2023-02-22" version="1">MDTKDQRSRSAQGNAPNSKIHGDGSPTPEENNYIRKNQDQTEPFDEVENTERRHPHAVRLFRGFFRWLCFCNHTPKADTSKELYLTNSILWSFHDSFHSVPHGTDLAQTSSPQPSTDPVFSDEESSPDQSAAMDELKNVTLDKQDLLDLFDSMCQEAKGMGHDVVGRVVQVLNFAAAVLDSRGGILSVDALGVHLYIPPGAIPAEESPQIVYMYVQGRNHLTPYVQCGPSKFEFRKDVILILPHCAKDAVDTKFNCVKSSSSGNQTIEGGKDGNVIVKSKSILMTMRHFCGLTAYGNPKAKYMVARVFIKDINDTNVMVRVRLFDDTKANLQEIQTAETRNGFVQVDMPGTLEVKRTDPEKDVRINLMCSDTDCWVITEPQSGWQTIQHSILWRECGPDNVPSFPSKIFKASMRRSTERAPFDGYLKVFQEGREEQSVDFALTYSLNVAKATSPRQITEEQVKEICRQQIREQLRGPVAESRLLDEETIRKLCSRLDEPSPIGRDWRILPENLTGLKGHGHGWVESIKTRAASGFLTPQSPTELVLDAFFATSRESDMGNRRTLQELKRGLHSLNRPDVRFAIKVIDDQICPDPQETNINVKTTYTLKFEKDGEVPEIKSEQDQPQMYRSQSLEQPPQRNFTAMNGTREDLGRDRASSTSDLLSSSISASDPEGQINKLDSKQRTDSAYESYNGLDTDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC57</accession>
    <name>A0A914BC57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073629.1">
        <property type="nucleotide sequence ID" value="XM_038217701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BC57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217701.1">
        <property type="protein sequence ID" value="XP_038073629.1"/>
        <property type="gene ID" value="LOC119741803"/>
    </dbReference>
    <dbReference type="GeneID" id="119741803"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037493800" description="Sugar phosphate transporter domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="8">
        <location>
            <begin position="646"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="131831" checksum="7C703952E0F53F32" modified="2023-02-22" version="1">MATVVLFVAVWWIANMVATISSKKAASGIKPDATDSLATWTGTAALKDLRWIELTMLQHLFGALLANTWLLVFRRKSVFPKESINPKHMLLAVTGNLVGNLATNASFAAVSSSLTQVIKSCEPIFTFVFALLFYKNSGNLTRNVLFSIIVMVVGTCLFISGEVSFNIWGLGAAVISNIAFPIRNIYLKKLGQSWDDPLQKIAVVSNLNVLILLPFAIMSMSSLDKLPRLESFTSATFHFIYNAASIMVLQAFSPVEHAMLNLSKRMFVILANMIVFSTPFTFWTVTGLLVIFSGHYNNQGGRIFMQIMKMRRCFSPAIIIFGISSFCWFVGFFRSDALMNQLQMQLTQYQPREVITTAWVYERPIPYNVVENIEAFLDRNPGMTVKVFCGTSQCMKAVQDTHNPEITGEFLVLPEIFKKTPLELWLARHPIHKILTGVDFEDHVYEAVRLALLWHHGGIHFDPSIKHGEFTIPGHQEAWVSIGTNLTQTKTHGVLSVSRFPVHSAFIANLTKAFCREYSRNITNGKPRSLQKFDFQRLVGNMLHRYCMSGDCCPTHIETELERISVVDARRRHFGTLSYASRARRFKRANVGDEVQSFPGIQFLPFVDRFVDRDNFNKAKRDTHIRMFFNAWYGDAGMTWPPPRNIDPITLSVHIHNRVRPMFTKYIKYLQSKEPIGCRDSDTLEFLKQNNVEAFLSGCLTLLIQTPNIEDKRSGQIFLVDVEKAFAALLPPDIKRRAIRVMHYKGKGGGKSTNKGRFQAAYNLIQKYSKARVVITQRVHCALPCVAMGTPVIFINFNRMPGGGAERGLKVSPRVTGLTTLFHTIDAFNMSQESIAQWLRDFNWRKPPPNPDVSMRMRLRATDWNVIRQDLVLYDSARKFGLLPLSPPATNTPNQLVFHLILNRTRNLTSLDWPKWRTIESIFYHYPHARIIIHSDNLQTGQFDVLTESGYTIEVHGLSANIVNNIMKNKIDIKHFRRFGSGLNEEDFAKLAVLFQWGGVYIDADVILLRQLDLSLINTLVWGSEKQNSFDLSFMRFERRHPFLETAILKASEWQASPKDGNVSAFEALLFHTWFNNFKNSVKVLPQGDFFKQFSAPNERDCLQSTFGPVFESSMKQVRLEVRFAKVKGLLTNLSKLKNGTICKYLFNSFCVLCNNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCQ8</accession>
    <name>A0A914BCQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073630.1">
        <property type="nucleotide sequence ID" value="XM_038217702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217702.1">
        <property type="protein sequence ID" value="XP_038073630.1"/>
        <property type="gene ID" value="LOC119741804"/>
    </dbReference>
    <dbReference type="GeneID" id="119741804"/>
    <dbReference type="OMA" id="WARYQAG"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036699324" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="38846" checksum="3B3AAE1F26F92384" modified="2023-02-22" version="1">MHILTSLLFVWMTGCLVKPGFTEEVCYGDIGCFTDEAPFDVFFRFPPMSPEYINTEFLLYTRLNPSLYMKVDRTDPASVEYSTFSPRRRTVFIIHGFTEKGSRAEWMKEMKDTLLEAENLNVFLVDWASGSRNLYTQSVQNTRVVGRVIAKFIQFLNTETGASFDQIHLIGHSLGAHISGYAGAYQPGIARITGLDPAGPNFRDNDPACRLDPTDAIFVDNIHSDGETLLELGMGLQQPLGDVDFYPNGGKEQPGCPKTVSDKLDDTESELKCSHFRAVYYFTESIQTTQCQFASYPCSSWDEFLNGQCSDCGALGCPSMGYRADSTLARGKFYLQTASQEPYCQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDS7</accession>
    <name>A0A914BDS7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074005.1">
        <property type="nucleotide sequence ID" value="XM_038218077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDS7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218077.1">
        <property type="protein sequence ID" value="XP_038074005.1"/>
        <property type="gene ID" value="LOC119742062"/>
    </dbReference>
    <dbReference type="GeneID" id="119742062"/>
    <dbReference type="OMA" id="MFRTIML"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="355" mass="39999" checksum="EA8A623233051E1E" modified="2023-02-22" version="1">MEANNTTVSNVTMVTDEVEMFVEMHPAWIATMCVFYIVVGFLGVFGNCIALVALATTPKLRNTCTALIGNLCVTDLITSFQLLFMMTPTQLLKGFPENLLLCAVVVYLPTTTYSVSLTTLMFIAFNRYLLITRPRTCYRACCGSKQVVLIIVLIWLINFMIFILPAITGTREVIYDREEQGCKTETNWLVGTIMFSFYVVVPAFVVVPLLYGLTICAVKASHQRVHARGTTGAVCEQPSALPPGHDGDASVVSTVSNSVKNNNQDDNPARHPRFISKRDINLTRLPILIFIVFAVCWTPQLINHICSRFMKVSVYYRKVATLFIWANSAINPYLYAWSNRNFRQAYQRILKNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEI0</accession>
    <name>A0A914BEI0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074376.1">
        <property type="nucleotide sequence ID" value="XM_038218448.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218448.1">
        <property type="protein sequence ID" value="XP_038074376.1"/>
        <property type="gene ID" value="LOC119742504"/>
    </dbReference>
    <dbReference type="GeneID" id="119742504"/>
    <dbReference type="OMA" id="EPHHIPS"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000157">
        <property type="entry name" value="Nesprin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000126">
        <property type="entry name" value="Spectrin repeat containing, nuclear envelope 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514:SF7">
        <property type="entry name" value="KASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14514">
        <property type="entry name" value="PKA ANCHORING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="8890"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="9">
        <location>
            <begin position="8912"/>
            <end position="8941"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="12">
        <location>
            <begin position="8882"/>
            <end position="8941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1818"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1885"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1998"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2241"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2891"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2924"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3210"/>
            <end position="3259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3417"/>
            <end position="3450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3584"/>
            <end position="3616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3826"/>
            <end position="3865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4181"/>
            <end position="4201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4471"/>
            <end position="4514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4789"/>
            <end position="4848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4875"/>
            <end position="4897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4983"/>
            <end position="5032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5047"/>
            <end position="5092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5310"/>
            <end position="5375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5396"/>
            <end position="5415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5505"/>
            <end position="5609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5673"/>
            <end position="5707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="5737"/>
            <end position="6059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="6378"/>
            <end position="6409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="8363"/>
            <end position="8449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="97"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="555"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="778"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1650"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="6059"/>
            <end position="6150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="6174"/>
            <end position="6204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="6575"/>
            <end position="6616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="6650"/>
            <end position="6677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="7944"/>
            <end position="7978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1847"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1890"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2893"/>
            <end position="2903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3426"/>
            <end position="3444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3584"/>
            <end position="3614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="4476"/>
            <end position="4489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4494"/>
            <end position="4512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="4808"/>
            <end position="4824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4825"/>
            <end position="4843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="5329"/>
            <end position="5347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="5348"/>
            <end position="5361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="5515"/>
            <end position="5529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="5695"/>
            <end position="5707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="5781"/>
            <end position="5795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="5858"/>
            <end position="5869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="5943"/>
            <end position="5961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="6010"/>
            <end position="6026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="6380"/>
            <end position="6389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="6396"/>
            <end position="6409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8383"/>
            <end position="8395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8396"/>
            <end position="8416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8426"/>
            <end position="8438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="8941" mass="992666" checksum="88D05B087FD53734" modified="2023-02-22" version="1">[encoded data, 8941 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFF8</accession>
    <name>A0A914BFF8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074666.1">
        <property type="nucleotide sequence ID" value="XM_038218738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFF8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218738.1">
        <property type="protein sequence ID" value="XP_038074666.1"/>
        <property type="gene ID" value="LOC119742616"/>
    </dbReference>
    <dbReference type="GeneID" id="119742616"/>
    <dbReference type="OMA" id="QCGLTKQ"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22563" checksum="D0EA504A37051483" modified="2023-02-22" version="1">MAAPMSSLTCQKRVRFLCSVYAVFISTFPILAFADYHFYSFSANDPRGIQVSLNAFRGKPALIVNVASECGYTKSHYQDLVWLSQQPEIDEKLHILAFPCNQFGQQEPASDREILAHVQETYGVAFPVFGKIDVLGKYAHPAYTYLINASGKQPNWNFWKYLVDRQGRVIDAWGPSTSVREIYGFLVAATKTGSGRRDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGB5</accession>
    <name>A0A914BGB5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074477.1">
        <property type="nucleotide sequence ID" value="XM_038218549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGB5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218549.1">
        <property type="protein sequence ID" value="XP_038074477.1"/>
        <property type="gene ID" value="LOC119742536"/>
    </dbReference>
    <dbReference type="GeneID" id="119742536"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964109" description="Sugar phosphate transporter domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="8">
        <location>
            <begin position="627"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="131082" checksum="F17DE995087DFCC9" modified="2023-02-22" version="1">MATVVLFVAVWWIANMVATIASKKAVSGIKPDATDSLTTWTGTVALKDLRWIELTMLQHLLGALLANTWLLVVRRKSVFPKESLNPKHMLLAVTGNLVGNLGTNASFAAVSSSLTQVIKSCEPIFTFVFALLFYKNSGNLNRNVLFSIIAMVVGTCLFISGEVSFNIWGLGAAVISNIAFPIRNIYLKKLGQSWDDPLQKIAVVSNLNVLILLPFAIMSMSSLAKLPPMESCTSATFHFIYNAASIMVLQAFSPVEHAMLNLSKRMFVILANMIVFSTPFTFWTVTGLLVIFIGHYNNQGGRIFMQIMKMRRCFSPAIIVFGITSFCWFVGFFRSGALMNQLQMQLTRYQPREVITTAWVYERPIPYNVVENIEAFLDRNPGMTVKVFCGTSQCMKAVQDTHNPEITGEFLVLPEIFKNTPLELWLARHPMHKILTGVDFEDHVYEAVRLALLWRHGGIHFDPSIKHGEFTIPGHQEAWVSIGTNLTQTKTHGVLSVSRFPVHSAFIANLTKAFCREYSRNITHGNPHSLQKFDFQGAVSDMFNESCMSGDHCPTHIETDLERISVVDARRRHFGTLSYARRAGRSTRANLGDEVQSFPGIQFLPFVDRFVDRDNFDKAKRDNHIRMFFNAWYGDQGMTWPPPRNIDPIMLSVHISPRIRPMFTKYIKYLRSKEPIGCRDSDTLKFLKQNNVDVFLSGCLTLLIKTPNIENKRSGQIVLADVDKAFAALLPPDIERIAIRVTHLGVGGGKSTIRERFQAAYDLIQNYSEAHVVITQRIHCALPCVAMGTPLIFINSKHMPGGGAERGLKVSSRVTGLTPLFHTVDAFNMSQESIARWLRDFNWRNPPPNPDVSMRMRLRATDWNVIRQDQVLYDSARKFGLLPLSPPATNTPNQLVFHLILNRTRNPTSLDWPKWRTIESIFYHYPHAKIIIHSDSLQTGQFDVLTESGYTIEVHSLSASIGNNIMKNKIDIKHFRRFGSRLNEEDFAKLAVLFQWGGVYIDADVILLRQLDLSLINTLVWGSKEQNSFDLSFMRFERGHPFLETILKASEWQASPKDRHFSAFEALLFHTWSNYFKNSVKVLAQRDFFKQFSAQNARDCLQSTSGPIFESNMKQIRREVVFAKVKGSLTNLSKLQNGTICKYLFNSFCVLCNNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGM6</accession>
    <name>A0A914BGM6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075249.1">
        <property type="nucleotide sequence ID" value="XM_038219321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219321.1">
        <property type="protein sequence ID" value="XP_038075249.1"/>
        <property type="gene ID" value="LOC119743014"/>
    </dbReference>
    <dbReference type="GeneID" id="119743014"/>
    <dbReference type="OMA" id="HEISTAN"/>
    <dbReference type="OrthoDB" id="2126785at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="39460" checksum="02FD11A8CBB06A29" modified="2023-02-22" version="1">MSFTGSKSQAEAANSFRSLLSNILPDLLREVDGSSKVEKVKAALRDVSQNYRTGLSTASLRYRTDWKEAANRCAYVFVYLIQHCNLVFYSLMQASERGTVSDYWSDLSTLNVCSVGGGPGSDLVGLTTFLEQSHVYPRMLNCLVLDLYPTWKRAWDAIAYYLPRQHWVSYKRCDLVGDAGLSADVLQFVRDADLVTLVKSFSAAAAFLRADRSRGSALRAILREIKPGCHVLYIDNDHDGDSQFRNDFADPAGLDLMFEERDFQSVPSGSYSEIVNKYCSALDFNPMKGCDVNIQLYRKKFPVKKYVSSGYTYHTPQNEIEACCCGIFGGLLCIAVCGLIGYGVYRLIRYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIY7</accession>
    <name>A0A914BIY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076248.1">
        <property type="nucleotide sequence ID" value="XM_038220320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220320.1">
        <property type="protein sequence ID" value="XP_038076248.1"/>
        <property type="gene ID" value="LOC119744402"/>
    </dbReference>
    <dbReference type="GeneID" id="119744402"/>
    <dbReference type="OrthoDB" id="9889709at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036766898" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="141"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="275" mass="28121" checksum="40C5291F67DF707E" modified="2023-02-22" version="1">MKICGATILSIALLLGNSVKLRASITGPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPVGPMGPYGQPGSKGDKGQQGVIGPIGPMGERGAPGNTGSKGDDGIGLPGKMGPRGPPGLVGAAGQAGVKGQKGEPGQTPDDSSQQVAFTVVRTSTSDESTSHDTRLPFQQTVTLLPGTSFDLETGTFTCSVPGTYVFTFSVLKNGNSGVLYIHLVKNDYKVISTYGHSNQLGQLSGSAVVVLQRGDTVYLTVYGRVQSSSTYHYISFSGFLLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJW6</accession>
    <name>A0A914BJW6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076210.1">
        <property type="nucleotide sequence ID" value="XM_038220282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220282.1">
        <property type="protein sequence ID" value="XP_038076210.1"/>
        <property type="gene ID" value="LOC119744380"/>
    </dbReference>
    <dbReference type="GeneID" id="119744380"/>
    <dbReference type="OMA" id="WSTRNHT"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038010611" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="22512" checksum="A3B7D671534325B6" modified="2023-02-22" version="1">MSTRRVLLLALLILGPVNARLTETQKREILQYHNDFRNNVYPKAANMVKLSWDDDLARKAQDWADSCVDGHNNVKSNSRWDWIGENMAYSTATDLRGMVKGWEMEGKIYDYGSDYCRTVPGDPMKSSCGHYTQMVWANTKFLGCGFKTGCPGYFSNRLVCNYGEGGNWIGEKPYESGGKCSRCPKGYKRCNRRLCVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM03</accession>
    <name>A0A914BM03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Laminin G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077313.1">
        <property type="nucleotide sequence ID" value="XM_038221385.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221385.1">
        <property type="protein sequence ID" value="XP_038077313.1"/>
        <property type="gene ID" value="LOC119745161"/>
    </dbReference>
    <dbReference type="GeneID" id="119745161"/>
    <dbReference type="CTD" id="1464"/>
    <dbReference type="OMA" id="QCKVIPL"/>
    <dbReference type="OrthoDB" id="9026019at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2321"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="75"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="8">
        <location>
            <begin position="257"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="505"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="633"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="743"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="859"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1555"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1662"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1806"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1928"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="2038"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2351"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2367"/>
            <end position="2379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2485" mass="274082" checksum="DD9AB982F4487D43" modified="2023-02-22" version="1">MRPEYHRGGERRYRGGDAMAGVVMWVVALQLMLAASGVSAVTRVLSKKSVWFEHASSLAFDFPFCKPEFHSCFFTASFYGTSHVYLPLSQASTETSIHLVIKTSRSKGLLLLAAGDTDYCIIQIRSGVIEARVNLGGGELAVRSLPKEKLNDLTWHSIRVELARGWLELYIDGVLHREERVVGQADTLNVQDGIYVGGTGMQKASYLKSADRFFRGCIENITYNDILVFNATAADKRSTVNDITWDCSEEFEAPADSPISFVKETAFVLYPRWQMDTHGSFACWLKTSSPLGLLMFSSGFRTQFVSAEVADGRIRVLMDRGNGVVDFTSQVPINDGNWHWIKIDIAPGNLRISIDYEPENVKLSDTSSAQALSGMLHVGGVIHKARSQAFRSDLKSITHASSGGSFQGCMRDVEVNNELFTLGDSRVTHGIEIGCVYQFPCSTDPCLWTETCTDTGPENFVCQCLTDECLESKQPSTDEPLLETSIPSRAETEPVIPINIQTELPEGTFSLVPISVEEGGRSVISSSNIHLNLKLRSYGLRESQLVLLIVKPPLHGRIESRVLRHDDDSSRFTLLDLMGSKIFYIHDGSENFYDELTIKVEILGRNVEIPEVLQGVVNFTLGINISPVNDVPSIALADDATLRMIKGSVQPIHSSFLGAIDPDNDPSDLLFTIVNQQANVGYFQKVSNAGESIVSFTQEDINNEQISYVHTGPSTKSRIVIRLFDGLEKSPLYSFRIEVIPLELSILNATELRLNPGSSVEITPAELNVATNDPEGHFEVSYRLTDSLRFGRLQQLELLSWWADVTEFTQADVDDGIIRYVATVSDKQRSIWNDRISLSASSEDVSIDVVLPVKIVVTSVEVTNNTGLILNVVRQGVITSENLAAEVRLPITFSSPRTFTVIRPPSRGQLVKQTTGLIPIGGSFTQEDIAAGMVSYFLDPSEEEALNDTFLFQVSVVNAQSSVTSFIITFIPDVRNLVVTNKGLNVTEGGTVVITTDKFFVTADNITDFAYTITKPPEHGRLLLTDPSTFEVSTSDVITFLNYDLMNDFLRYMHDDSETQADSFEFTASASYTDLSGRKRSLHHEGTFDINILLQNDHEPEVVVNRLFKVVKGGKTPLTDQNLLSADRDENLNDDNLEYQRENTDVGDLIYAANESSVYRFTQRQLKDGLIAFRQRGDILAGRMLFYVFDDDRSRFASDFLDIEASEPFVGILNNSGLKISRGSSVVLTSCNLSAETNLGIKDNRIEFLITSQPSHGQLLYRGNPAIMFNQEGLEAGRVVYHHDNSTAMMDSFNFTIRARSMVKEAVFNIRIYVASHQELPEVEQLKPLVVEQGQAVIIDRSHLRITHPNHLPIEIVFTVTVQPKFGILQLSDESLSPTRRGRRQAEEQLKTFTQLDVNRNRLRYVQTEPGVGVDRFSFEVDNGFVKVSNLTFAVEIAPTVVPLAVADFFLPEGGSKAITNEIIQVANPYYQKWYFDFTIQQEPIHGFLETTRNAGERLTSFSTRDLTNELIYYVHDGSDTLNDSFTIAAISSETGKTSLSYTINITVTPVNDQKPEVTVNNGLTLFIGTQAQVTTDVLSTMDLDTDDQSLTYILTAPTNGYLVKLPDKTTQVMSFTQSDLNNGDIVFIQSGLNTGGFRFSVSDGVHSTVQQIFSITARPLLVSLESHAMLYVEPNSIEPITAQHLKAVTNEEPKTNLSQPIRFLITEAPKHGIIVEILDRDEIDEEILSFAQISTFTQAQIDRNVVAYKQILDSPVTEDQFTFSVVLPLSQNLTDQIFEISIGLREETTTAATTVIPTTILPTTEPSLILNLGIEVQEGGTASITDKQLNIATLAEDLGEVESVFEYNIVSLPSHGVLKKSNQEITAFSTFMQEDLVDDGIQYIHDHSDERQDSFNFTVTATAVGSTEQLVAYTGQFVITIDPVNDQPFRVLTRTLSMTITQGSNKTLTMDDLNTVDADNPPDEISYVLLSSPSNGKIVLTSDQSTVIQEFTQKQINDGEVTFVHDGGVVSGGFLFRLTDGARMKLKQFSIIVEPVTLDVAITGNLTLTQGDSLAVIPSTIFNVTTNDDGERIRYNISTAPEYGEILVDSVATSSFSQAQLNQGSVQYSQTDFSSEMDLVKFTVFDDYNILEDLNLTVTIKPAITLKLMNITTGKSLALTTEYLNASELSSSIGGGLAIEITRSPQRGLILNSTSNLAISEFPYSDVVNARVLYVADFLNLGVNDTLDDSFVFVLSGERVQPATLTFQVRIVPPILVSTTSIAPLSTTVQPVTRRINTINFGINRAGEIPLPTEEVTTSTATSGNTPIAKSFEPSGFNPVFVIIPIIVIIVIIILVLFVLIWRSRSKEKKHVSGRESPYPEPDVGPYPGAQAGPGQTGLMPTVQVSGACPDHHSTGSLNGTPPVTMVRPVPIQGPYVPQVTVTQLGRPPSPNYPSSFASVNSNGTVQSGGSSHSSFTKWDSYKPEVIDYCPAKKPTLKKSQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMI0</accession>
    <name>A0A914BMI0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077150.1">
        <property type="nucleotide sequence ID" value="XM_038221222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMI0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221222.1">
        <property type="protein sequence ID" value="XP_038077150.1"/>
        <property type="gene ID" value="LOC119744998"/>
    </dbReference>
    <dbReference type="GeneID" id="119744998"/>
    <dbReference type="OMA" id="WAMYILN"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="311" mass="34284" checksum="B815180C7E7FAD91" modified="2023-02-22" version="1">MAEQAALAFQAVVGIVGICGNGLVCGVIAKVRFMHTLTNAFIFNQALVDLIGSLVILLQRFVPIPDPIPPGAIGVLLCALWATKFLQWGPFTVSTFNLIALTLERYLAIVFPFRYQTLASRKKATAVLVGMWVAGFLFSVYSIYFRYYEDGECVPNQVAHPRVIGVCVFFVKFFLPVSVMLVVYGHIMVVLKKGTGRIQPGPAAAGPSTEGQGESLMRARRNTFKTLLIVCVAFIICWSPDQIFFFLFNIGVEVDFNSPVSYLFVGMVSLNCCLNPFIYAIKYKQFQKALKVVFGKRGDRASVATLSTGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNP4</accession>
    <name>A0A914BNP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">E2K</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038077754.1">
        <property type="nucleotide sequence ID" value="XM_038221826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221826.1">
        <property type="protein sequence ID" value="XP_038077754.1"/>
        <property type="gene ID" value="LOC119745467"/>
    </dbReference>
    <dbReference type="GeneID" id="119745467"/>
    <dbReference type="CTD" id="1743"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="93"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="52261" checksum="2B2A1B455A38DE06" modified="2023-02-22" version="1">MTSGTFRSHRMLSSIKVAGRFPRILPSFRHVQAHRQPVQVARSFSCSGLEIQGLLGRHASQQFNRLRTLSKNTPCIWPSSRGLQTSSIYYDEIHTVQTPPFAESVSEGDVRWEKAVGDYVKEDDVVGEIETDKTSIPVPSPVSGVIVEFLAGDGDTVVAGQELFRVQLSGEAPPKAASPDTPKADTPKEAPSAPPPPPPPSPPPPPPPTAVAGSIPTTPPPVPPMPTAPMTSKPAASVTPIVAPASGAMPGVSARTEQRVKMSRMRQRIAQRLKEAQNTAAMLTTFNEIDMSNIIAMRKQHREDFLKKHNIKLGFMSAFIKASAHALGTMPAVNAVIDDAEIVYRDYIDISVAVATPKGLVVPVLRDVGGLNYADIEKALNEIGEKARTGSLAVEDMDGGTFTISNGGVFGSMFGTPIINPPQSAILGMHATADRPVAIDGKVEIRPMMYVALTYDHRLIDGREAVTFLKKIKAAVEDPRVLLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPW4</accession>
    <name>A0A914BPW4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077537.1">
        <property type="nucleotide sequence ID" value="XM_038221609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPW4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221609.1">
        <property type="protein sequence ID" value="XP_038077537.1"/>
        <property type="gene ID" value="LOC119745322"/>
    </dbReference>
    <dbReference type="GeneID" id="119745322"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="13418" checksum="ED5CAC464F49812B" modified="2023-02-22" version="1">MLVSQSRTSSMLTGIVAVGQVYRQSSIGLGHGDVGLSWMYFIFCIASPPASPLSTIPSTGHFAQSFPAAFSSGTSRTSPGFAAPRGRSCESSLVGMPPRRPRSLPTSRRGSWRGTAAGKLEEWGTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRN4</accession>
    <name>A0A914BRN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078625.1">
        <property type="nucleotide sequence ID" value="XM_038222697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222697.1">
        <property type="protein sequence ID" value="XP_038078625.1"/>
        <property type="gene ID" value="LOC119745970"/>
    </dbReference>
    <dbReference type="GeneID" id="119745970"/>
    <dbReference type="CTD" id="361"/>
    <dbReference type="OMA" id="TECLAVF"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35986" checksum="6E34E2DC9E470701" modified="2023-02-22" version="1">MDVIRKRLRGINAATIFLSYHKLLNESPPGRRRHEVVYETVVGDLILWRAVFTECLAVFLFVFLAAGSSVAWPGGNAPSNLHVSLSFGLVIASLVHCFGDVSGAHLNPAVTLPLMFYRELSLVRGLLYIVAQCLGGFLGAALLRVATPTDPRYDTTLGCTLLGENVSAGQGFIVELVASLQLVFTVFTTTDPRRKDNRIPPALAIGVSVALGLLFAIPFTGASMNPARSFGPALSAGNWSNHWLYWIAPLLAGLIASTVYRRLFAPGTLIAGSKPATTARRRHRQRVEEEAETGSIHGNTLEEDVSERVALTPPHHADEITNNVTGSHIITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRW9</accession>
    <name>A0A914BRW9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078710.1">
        <property type="nucleotide sequence ID" value="XM_038222782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222782.1">
        <property type="protein sequence ID" value="XP_038078710.1"/>
        <property type="gene ID" value="LOC119746025"/>
    </dbReference>
    <dbReference type="GeneID" id="119746025"/>
    <dbReference type="OMA" id="CWASPRR"/>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037687483" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="233"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="556" mass="61218" checksum="3B3BE6C9E6CA6068" modified="2023-02-22" version="1">MDMASWWKTAVGLIVVLVPLVSSQVFLTEPRDAEVLMNAPMTMPCSISSTTQATVYWEVPGSVNRLYVEPNQQLPAGTPARFSIGGQDGTGNYNLNISRVQIEDEGMYTCNVIVDDGRGDIQPETLTSQSAILTVIRVPPIGDPVCWIREGRLVEVGDDLSLMCASSDPTVELKWYLGDVPLSSSNFETYSPGPGIRYSILAESSVNQRTFTCQPNKGQYEACQVTVVVRHSPIVTIEADAMMETGIDATFTCTAIGNPPDFAYTWHYNEYQISFAQHPRFNRARLEKSGSVLILPDLTDSDNNATLRCEAVNDVGEATASHVIRALPGKTLAQIIGPILLGIILGLVLIVLLLYAIWWRRQRRKVKQINKKKSVKRSFSLRNRAQEDVPTVDSGIVYTQTRGGFGSRYGKTATSNGDLARSGLDLESAGYGPDVTSIPAYRATAEEEREDDGALRPIPRKTSMSSLASGARGQSTTADDASLISPNEEKSFTYYVNPHFDEYRNSMVKIETEENNLDPEMEEEKHAPPPYNIGEDSPELKPSNDVKDENIISTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTR6</accession>
    <name>A0A914BTR6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079027.1">
        <property type="nucleotide sequence ID" value="XM_038223099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223099.1">
        <property type="protein sequence ID" value="XP_038079027.1"/>
        <property type="gene ID" value="LOC119746261"/>
    </dbReference>
    <dbReference type="GeneID" id="119746261"/>
    <dbReference type="OMA" id="EPYLCAF"/>
    <dbReference type="OrthoDB" id="10014804at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33647" checksum="48A07EFF076B2743" modified="2023-02-22" version="1">MASQPGLNKVFLWSTPRCVSTAFAKCMSYVDGMQVVHEPYLCAFLLDVERDKPKDPNEDERRIEERTYEVLDPSVDVGEGFDEKTCTYSWIKDELLSGKQYPDKKIIFCKDVAHHLAGKYHMLPEGFKYSFAIRHPAKVYLSLKVLLTRFYGEEIDLLKLPLFPPGYGYKELYDLVEYVKQNLDPNPTIVDTDDLLDDPSGILTVYCQKMGIPYSDSLLSWPAGDDIVKQWKIAKYLLKGDRLLGFYKAAFESTEFVKPKPPPLLEALPEDVKKCVHATMGYYEKLRKDRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXU3</accession>
    <name>A0A913YXU3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044358.1">
        <property type="nucleotide sequence ID" value="XM_038188430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188430.1">
        <property type="protein sequence ID" value="XP_038044358.1"/>
        <property type="gene ID" value="LOC119719110"/>
    </dbReference>
    <dbReference type="GeneID" id="119719110"/>
    <dbReference type="OMA" id="ICAFYIC"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="377" mass="42039" checksum="F837BFF14AA7B8D5" modified="2023-02-22" version="1">MRITRSWTEILLNFIMAFSSNISENYTNFSNSIKPHNISATESIYGTYAERQILSGVGFVATFVGLLGNLAVIFAILTVKKLQTKTNVFVLNLAVADVLTCTVAPLQAVTILSDELVIPSWLCKLVAFCIITCIGCSINTLALIAVNRLVGITTTAMYHKVYTPIRLFLMIVMSWAVPIAVATIPLFSNYAKYGFNPIYKSCTWSSNMSYIITYAKLISVMYFPLQFTILFVSYLKIYLYVTRTTQSMLRLDKYGGTTGLGSQTLQIQLWKRQVTVTKNLFTVVCVFFLCMCPYFATLGLPSNVGKSLLSYASLVLMSNSAVNPIIYGTKHPDFRTAFAHILRCKRKKYKPQTPRTKSGQNSTTIATISANLQLQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYR3</accession>
    <name>A0A913YYR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044868.1">
        <property type="nucleotide sequence ID" value="XM_038188940.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044869.1">
        <property type="nucleotide sequence ID" value="XM_038188941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188940.1">
        <property type="protein sequence ID" value="XP_038044868.1"/>
        <property type="gene ID" value="LOC119719467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188941.1">
        <property type="protein sequence ID" value="XP_038044869.1"/>
        <property type="gene ID" value="LOC119719467"/>
    </dbReference>
    <dbReference type="GeneID" id="119719467"/>
    <dbReference type="OMA" id="VMTFANI"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="233"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="541" mass="60016" checksum="D1064105EA26CD89" modified="2023-02-22" version="1">MASTNPAKDPNESSEMATPTSESIVQAFTVYASSKDAEIKELKAQLAAAESENLDLKSQKATWFLEKKSLSDRVERLERELKMLQDLQRRQAAGVSSMGVSTDGRGDAAPGPLLSRVESLEKGMASVRIGGEHPESCPSPVCSEHLVETDGQITDLPNTHLKSALLAGSDVPQTETTAAGEGKVPAGRAAVPAETKAAAMASQQGAFDKLESRSYSFVQVSSKEKVTECPVSTEMMEWLSENLTLADWKPLMRKLGLTDVEIGNASFGHPHVVEQRYQCLLHWRKTHSRSATVPTLLTAIRAKSLHQLARDFCKEFPAESSPVETKRESTPELTRNFLSNLERFLDPFVADFDALKQDLHNGPRISQGQCLKIGYRSQEGNGRLDTVMEDWSSTYYKKNNSDSELDKRWALRKFLQNCGKEVRAIFKKHVNQGGVIGPAAGDDAKIGNLPYSTIQDIEEMLSYTDGVRNWKDLADWLRKQHPSVFQPVTKNKIRLWENDPDPRKGAKSVLQVWETTTQAKVGALYSWLVENGRLDIAKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZI2</accession>
    <name>A0A913YZI2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small VCP/p97-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044983.1">
        <property type="nucleotide sequence ID" value="XM_038189055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZI2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189055.1">
        <property type="protein sequence ID" value="XP_038044983.1"/>
        <property type="gene ID" value="LOC119719578"/>
    </dbReference>
    <dbReference type="GeneID" id="119719578"/>
    <dbReference type="OMA" id="GMCLPCF"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904240">
        <property type="term" value="P:negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055366">
        <property type="entry name" value="SVIP_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269">
        <property type="entry name" value="SMALL VCP/P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269:SF1">
        <property type="entry name" value="SMALL VCP_P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9341" checksum="2D300858EAB4E45D" modified="2023-02-22" version="1">MGACMPCLFGSADDYDQDQPDEETRRQQQAEAAQKRMKQEESRGLADPEGAKRRQQQKEEAEKKAEALEQQGGGENKLSWQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0H1</accession>
    <name>A0A913Z0H1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045409.1">
        <property type="nucleotide sequence ID" value="XM_038189481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0H1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189481.1">
        <property type="protein sequence ID" value="XP_038045409.1"/>
        <property type="gene ID" value="LOC119719991"/>
    </dbReference>
    <dbReference type="GeneID" id="119719991"/>
    <dbReference type="OMA" id="KFPRICA"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037286502" description="Protein NATD1" evidence="4">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="161" mass="17918" checksum="668F23F2B615F23B" modified="2023-02-22" version="1">MMSFSRLANVLFIKFPRICAVTTSSNSYKYQPASKFLPRLLISHCPVRLVAKGRLASTMAETSSDLTVDHDVENKMFVINLAGEPEKAVLVYKVIGPDAVNLYHTGVPVSQRGKGIAKVLAKAALDHFASHGTNMKLTCTYLQKYFRENPLPQYKSRVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z609</accession>
    <name>A0A913Z609_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047149.1">
        <property type="nucleotide sequence ID" value="XM_038191221.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047150.1">
        <property type="nucleotide sequence ID" value="XM_038191222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047151.1">
        <property type="nucleotide sequence ID" value="XM_038191223.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047152.1">
        <property type="nucleotide sequence ID" value="XM_038191224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z609"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191221.1">
        <property type="protein sequence ID" value="XP_038047149.1"/>
        <property type="gene ID" value="LOC119721243"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191222.1">
        <property type="protein sequence ID" value="XP_038047150.1"/>
        <property type="gene ID" value="LOC119721243"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191223.1">
        <property type="protein sequence ID" value="XP_038047151.1"/>
        <property type="gene ID" value="LOC119721243"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191224.1">
        <property type="protein sequence ID" value="XP_038047152.1"/>
        <property type="gene ID" value="LOC119721243"/>
    </dbReference>
    <dbReference type="GeneID" id="119721243"/>
    <dbReference type="OMA" id="VWEGTSH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000038">
        <property type="entry name" value="Si:dkey-10o6.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="36469" checksum="D2B1AF082E893A9F" modified="2023-02-22" version="1">MGDSTDNIPVIDFSAFKLSLDKPDYDSEAFKKLVQSVHHALTTIGFFYIVNADFPPEKLERMWKVSKDFFHLPAEIKNKYPRNPKENHGYVHMEREKLNPDRPHGDLKELFNYHPMTAEDSLWPTETECPNFKSVLSDFWDPCLALHQRVLEVMGHGLQLEDPLLFVKHHVKSYENSGTTLRTLYYPAFKDVTVKEEQARCGEHSDYGGITLLFQERPGLEVRTRKGDFMQAQMVEGGILVNIGDLMQRWTADKYLAVKHRVLLDTTSEESVKPRQSIAFFGHPDYDALIECIDGSNKYAPVNSLDYINMRFGLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8T5</accession>
    <name>A0A913Z8T5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048154.1">
        <property type="nucleotide sequence ID" value="XM_038192226.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048155.1">
        <property type="nucleotide sequence ID" value="XM_038192227.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048157.1">
        <property type="nucleotide sequence ID" value="XM_038192229.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048158.1">
        <property type="nucleotide sequence ID" value="XM_038192230.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048167.1">
        <property type="nucleotide sequence ID" value="XM_038192239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8T5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192226.1">
        <property type="protein sequence ID" value="XP_038048154.1"/>
        <property type="gene ID" value="LOC119722179"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192227.1">
        <property type="protein sequence ID" value="XP_038048155.1"/>
        <property type="gene ID" value="LOC119722180"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192229.1">
        <property type="protein sequence ID" value="XP_038048157.1"/>
        <property type="gene ID" value="LOC119722182"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192230.1">
        <property type="protein sequence ID" value="XP_038048158.1"/>
        <property type="gene ID" value="LOC119722183"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192239.1">
        <property type="protein sequence ID" value="XP_038048167.1"/>
        <property type="gene ID" value="LOC119722192"/>
    </dbReference>
    <dbReference type="GeneID" id="119722179"/>
    <dbReference type="GeneID" id="119722180"/>
    <dbReference type="GeneID" id="119722182"/>
    <dbReference type="GeneID" id="119722183"/>
    <dbReference type="GeneID" id="119722192"/>
    <dbReference type="OrthoDB" id="191169at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="15344" checksum="710DA4A734D544DF" modified="2023-02-22" version="1">MDENIETKERFFEKHKLEWELRQREEEIAELQKALSDMQVYLFQERDHVLRLFAENDRLKIQELEDRKRIQHLLSLSSPSGPEVTYFHKEPSTRAIVTQKHPQKRHPHAEGEILGFKSQSAKQTTEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9X6</accession>
    <name>A0A913Z9X6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047690.1">
        <property type="nucleotide sequence ID" value="XM_038191762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9X6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191762.1">
        <property type="protein sequence ID" value="XP_038047690.1"/>
        <property type="gene ID" value="LOC119721803"/>
    </dbReference>
    <dbReference type="GeneID" id="119721803"/>
    <dbReference type="OMA" id="HEQENCT"/>
    <dbReference type="OrthoDB" id="10057631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120160">
        <property type="term" value="F:intraciliary transport particle A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040028">
        <property type="entry name" value="IFTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543">
        <property type="entry name" value="PROTEIN C11ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17722">
        <property type="entry name" value="IFTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="34048" checksum="8CF36C80A392DF54" modified="2023-02-22" version="1">MNQTRRYTIAQNMAAGNQEQDNRTNTLTEEHMRSAIETVLGKTEQSYEDFMSCFTSLRKEDVVEHQAQQLQKMLRQQNDMAEGQRSHGVMNPIGDLKLIEHGSKKDDIETEELDEGHYAPTRQSADLPAGPRFVQMDNFVDDAELLEDDLDNDEEFASCRYESSFGIVDSSPASSALKLTRQLVERIEEDEGNDNKDEISQAHPEFGGGCEMRTLPGEAEEEEDGQGVLSLSDDAVHRTELEMSTRCPEAVATEDDPQSETRLEDSSDEVQPFSLDADFDYDNVALTPKWDSNHGPPGWKPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAM6</accession>
    <name>A0A913ZAM6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin polyglutamylase complex subunit 1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048813.1">
        <property type="nucleotide sequence ID" value="XM_038192885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192885.1">
        <property type="protein sequence ID" value="XP_038048813.1"/>
        <property type="gene ID" value="LOC119722654"/>
    </dbReference>
    <dbReference type="GeneID" id="119722654"/>
    <dbReference type="CTD" id="91978"/>
    <dbReference type="OMA" id="HFQMECE"/>
    <dbReference type="OrthoDB" id="64214at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22960">
        <property type="entry name" value="DD_TPGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047502">
        <property type="entry name" value="DD_TPGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039235">
        <property type="entry name" value="TPGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057632">
        <property type="entry name" value="TPGS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31932">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31932:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24480">
        <property type="entry name" value="TPGS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin polyglutamylase complex subunit 1-like C-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="258" mass="28962" checksum="64BBB5BDA870BE6B" modified="2023-02-22" version="1">MSDNKKKADDRIVSGNNESKREFLEKSGVGNWIRDALSKILSNRPDDAVGFLAQYFSTLGEKSNRLNRAYHYLTLSDHYQPAFANNVSTAYEILSSSSGSRTPAGLMGSAYRDVLNLICRNIPATFCEHLLNKIGPRDEEVIYPDIFHSGVVAAFVLIDYLKQTEELFQLLTTHQSKGVVDHELATTMLQELQDALSVKTTDPISILTAGSKLTNEVITDSLLEMLLASQNERRRTMTKDEFVHIAFNIYLKEVKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBT6</accession>
    <name>A0A913ZBT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048350.1">
        <property type="nucleotide sequence ID" value="XM_038192422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192422.1">
        <property type="protein sequence ID" value="XP_038048350.1"/>
        <property type="gene ID" value="LOC119722354"/>
    </dbReference>
    <dbReference type="GeneID" id="119722354"/>
    <dbReference type="CTD" id="55631"/>
    <dbReference type="OMA" id="CMLHKLT"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000116">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000193">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="96"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="606" mass="66878" checksum="11BF1F2FB4A06BF9" modified="2023-02-22" version="1">MSRNRGGGVGGRAPLKPRAGFQKPAQQDSNAVSSALLKQAMRSGQLNLSNRELAKVPDSVWRINIDIPEEAKTVSLDKTEDGWWEQTDLVKLILACNKLQEISNDIQQLPALTVLDVHDNVLTSLPPAIGELLNLQKLNISHNKITSLPSEMFQLRHLLSFHVEHNDLTELPEGIGEFIHLEELNLSHNKLTTLPYTAGHLGKLKTLNVSDNQLTSLPTSMGMLKAVRILEASNNKLPEIPTEVGDMKSLEQLYLQHNVLSGLPLLRACISLKELFAGNNRITVLSPDHLEHLATVNVLSMRDNKLYQIPEEIVNLRSLHRLDLTNNNISSLPNKLGTLTSLKSLVLDGNPMRGIRRDIISRGTQGILKFLRSRIEEEPSSKDATDSVSASDPSSAMGVVAAVTSKTLDYSNKKVAEVPVTLWEPAREAGVANVNLSKNVFTEVPTNVILLAKTVTELNLSFNKLTTLPAELQMMVNLTHLDLRNNAISTLPSEWSTLVKLREISLSCNRLKEVPAVVYQWAELENLLLADNQIGLIDVVNLLRLPKLSTLDLQNNDVMQVPPELGNVQSLRSLQLGGNPFRNPRPAVLAKGTPALLAFLRDRIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZED5</accession>
    <name>A0A913ZED5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050153.1">
        <property type="nucleotide sequence ID" value="XM_038194225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZED5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194225.1">
        <property type="protein sequence ID" value="XP_038050153.1"/>
        <property type="gene ID" value="LOC119723520"/>
    </dbReference>
    <dbReference type="GeneID" id="119723520"/>
    <dbReference type="OMA" id="GCLQFSH"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000004">
        <property type="entry name" value="collagen alpha-6(VI) chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036788625" description="VWFA domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="560" mass="60602" checksum="1643EECBDA9EDEB0" modified="2023-02-22" version="1">MLSMALWRAVTAAFLLLCVTRVGSVDLTITPGAVGPEVVEATVQRILLSDIFSDDFSLLRRLAAVETADGTDSAAFAGGLAGGIWRVSEEAFQRTKELTDVGWESYYNGILDGSFGVNWRDVTYSDLQVPLISALAARIYVLMTSPPVDKVAYEAEEQAAWWMRYYNTEGQEFEFLIKVAELEQQAVCKIGMDVVFALDASLSVGSEGFFRSKNFVKQVVDAFNIGSRDDQTRVGCLQFSHEVTVAFDLGDHDNRDDIMRAVDEINYNGGGTAMGTAIDYIRQNSFSVDRGARPVDYAVPRIAIILTDGKTNKEFPILFPSALAHRDGIIMYCIGIGDSDDSELSLIATRPIASHVLHVLNYESVSYLKNIMATRTCRETTAVAVGQPIRTDLEEGEARFISYEIDATEGATIKFMAPSGLVTVYLSSEVPNPNEAVHDYKVEPDGRVDLFIDPTQLASMSRTKRAADGASDPSHVKVYTAIYSRSNGTQLYVESSAGNTADHSFIPEAPSGTVAPVDPGAGPQPAPQLGSNAPPGPSTSVLIGVASLVMIAVVHAQLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEI7</accession>
    <name>A0A913ZEI7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049889.1">
        <property type="nucleotide sequence ID" value="XM_038193961.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049897.1">
        <property type="nucleotide sequence ID" value="XM_038193969.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049905.1">
        <property type="nucleotide sequence ID" value="XM_038193977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193961.1">
        <property type="protein sequence ID" value="XP_038049889.1"/>
        <property type="gene ID" value="LOC119723357"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193969.1">
        <property type="protein sequence ID" value="XP_038049897.1"/>
        <property type="gene ID" value="LOC119723357"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193977.1">
        <property type="protein sequence ID" value="XP_038049905.1"/>
        <property type="gene ID" value="LOC119723357"/>
    </dbReference>
    <dbReference type="GeneID" id="119723357"/>
    <dbReference type="OMA" id="HINDHIR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="267"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="525" mass="60252" checksum="77F757AC1B2CEE46" modified="2023-02-22" version="1">MEENQPLARATYRPLSNRKKKLNHSISWRERLSKSKETFKGDLEHLFRDKFTGNHAVKMARKRERIICEIFATERKYQSHLAIIVQHFLTPLESLGLIPADDHRIIFENITAIQAVNRELLAHMEEQGIAQAFIQLAPFMKVYCAYVNNFEKASQKLQDWERKRAAFVQFLREQEGKPECANLTLHALLITPIQRIPRYKLLLEELLSSTDENHEEYEQLQEAAARMTEVTYGINEYIREHENFQKMLLIQTSLTGGAPRIIAPGRKFIREGTLMKVSKKGSSAHERMFFLFNDMLIYAKPNLLDPLVSTRSYCCRGVIPLERCEVQCVLGELKTSGTGALFKVVHGDQSLLLYSTNHNIALSWIDALQGAIQQLQQRQQSSRYTQHSVSGTKTRGPTRNVPLGKRVRHIGLRTSNRLKNMRNYPEPEDGDHSKDSLHPLRVQLHAKKLHGPGNTPLRKGRPRRLQRGPLQVRNNKQEESQDTSLSMVDVTGYPDNTEDPHGCIQSPYTTLLDQETGQQAFCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF71</accession>
    <name>A0A913ZF71_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050104.1">
        <property type="nucleotide sequence ID" value="XM_038194176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063278.1">
        <property type="nucleotide sequence ID" value="XM_038207350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194176.1">
        <property type="protein sequence ID" value="XP_038050104.1"/>
        <property type="gene ID" value="LOC119723494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207350.1">
        <property type="protein sequence ID" value="XP_038063278.1"/>
        <property type="gene ID" value="LOC119733971"/>
    </dbReference>
    <dbReference type="GeneID" id="119723494"/>
    <dbReference type="GeneID" id="119733971"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="299" mass="34161" checksum="9FE8BEF46CD53D44" modified="2023-02-22" version="1">MMVDVRTPLQLCGFDPVPAETCNLEVPDVQPQSEMLRLLQHQSSMQEVILQQFRQINALKEMMRQVMGEQMRQRCYIHSLECALSDVKVNQRPPNQPVPEVPIPHRPVPKTPNPQPVHEVPKPIPQPAPETHASTPDEATQASSQGGMSSERISLREAQLKDPAIRRVVELKTASPLMTRRQMSQETRVVQKLLGVWRRLEVKGGLLMYKKGGGKATCRYLAVLPRQQREEVFHSLHGSMDKFGYGRILKLVKDRYYWPSLHNEAMAYMRCHRRGVQRNGREASGEISPPPEFRDDRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFL5</accession>
    <name>A0A913ZFL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050587.1">
        <property type="nucleotide sequence ID" value="XM_038194659.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194659.1">
        <property type="protein sequence ID" value="XP_038050587.1"/>
        <property type="gene ID" value="LOC119723795"/>
    </dbReference>
    <dbReference type="GeneID" id="119723795"/>
    <dbReference type="OMA" id="DWITHKF"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1351"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1299"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1407" mass="162892" checksum="8EC967D1F7671F74" modified="2023-02-22" version="1">MGLGQSKKASLESHSDFKAVRASRQSSEQSIKSERFVSPPTSPIPGFHSFAPVDGTQRATKTKPLGFKETSVDTQSTTVNQKISFANATELEKRLNQLQHERSLCNSNEVSTSKAQQLRQGKQQQKCLEPTQKQEHEQFAQQQQQQKFQQLQQLPQNRLQQKQQQQLYVHQQQQQKLPLRQHQQSQNRPLQQKQQQHQYVQQQQQNVCQLQLPTQHTPQQKQQQHHSVQPQLQRFQLQQQLQQPKQQSQKLQQKQQQQQSAQNQKSAQQHQFEQLQQQQQLQQYQEEQSQKQPSQQNRLKEEKSAKQEQPQQQLELMYQKQFQRKPNLQKQEKQQPVQPPQLQQFQKQTSQKRLQHHQQQHFQQQFQQQQPVQAAKQQSKQQQLQQIQRQDLQQDSSTQDNKEQLPESEHQKEQNQPRSQQDKELQKLSTQSSKQRLNQQKKAHIPQNKNEPQPKQPQQHQKENEVQEQCSKENRDIMEQQEPISDYLDTPQNQQQNHKVQQRQQENQPIQQRQQENQPIQERQQENQPIQQQHMQQQQKEINNQSQMETQSQPKKHQQLSQVVQEQQQKQQQQQHNQVQNHQSKKTKKQLKREQRLRMLQEQQFGKNTTQHHEKQQTQQQQNQEQTEHLSNQAPRPQPQLNQQIKLQSKELKDQETLKVKVQPENQKQMLMEQHTKQQQPTQQKQVHQDQHQLQQTLTEETTKKHDQHGQTKQKGDFAANNGQGKPSKEEAVKLDLASTYKAKPGRKLTVQNDCVLHVKTQHGKPVPLMTIDFSNPGPLNPNHPLQPPRELATTADPSKQKSQKRSLCATSSNADARPQTLLSTHPSIQAPRSTISSQLNVQGNQGSALNEVSQEITNCKQTTFVPLKKTFRTATKLNCRHIPSQLESQQIPDHLEKEQIKIQDQKEPDELQQQLQQEQQQQKQKLQKLKQNPHKKQQHLQKQLQQRRQQEEEQQQQQLAVESTSPGREKLKAVHKQQPHPPAFAASAAALQAQLALHPTQPTHTARKHKSVTGDATMEIFKTLQAQDSTAAPQTNTNSSGAQMQQSVASWAVVCDRMPDQDFLNKPSADGTGKKERREGQGFFSRIFGRKPKAESTTIKHQKAKEISSSLEELSADMQALKIDSASSIHEMEAPVDIDADQTRSDTKSQSSSSDDEEGSSSAESDESSDPQPPSCMETWEIADDVVEKALCLLPIQVGTVHSRRFTLPDCPFEPELVQRLVLDALEAKRGLKRIKEDQTLLMTFRDCLLKFFEGKEVTDVLPPCNHPPGSNQCNMQPVIQPLVGIIRHVLREKKTVAEPPRKAALRPTQNRRGQAEHGELRPRRYIKIKRKLTTAKALRTPTKLLVRFCNTCGDSKQPNGQPLFSCGRCQDVVYCSRECQNVDWITHKFTCPGGDRHSYCKHHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG45</accession>
    <name>A0A913ZG45_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="19">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18 19">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_038050021.1">
        <property type="nucleotide sequence ID" value="XM_038194093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG45"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194093.1">
        <property type="protein sequence ID" value="XP_038050021.1"/>
        <property type="gene ID" value="LOC119723439"/>
    </dbReference>
    <dbReference type="GeneID" id="119723439"/>
    <dbReference type="OMA" id="NGYVDPP"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 18" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="521" mass="57750" checksum="D779B5F2D2A50B2E" modified="2023-02-22" version="1">MVPTVRTDACVIGAGISGLAAAKCLQDAGFAVVVLEQSDRVGGLWAFRERGYGVMRFTHINVSKYNYCFSDYPFPDETPDFPHHSHMARYVDDYTTHFGLDKIIRFQMKVVSLTRQDEEWIIRAARVDADKHGEEKLGEQETFIVKYVAIASGHHAAPNQPKFPGQESFKEEIIHSVSYKDAITSGIVGKRVLVVGIGNSAVDVAVDLAATGRSKAVYISTRSGAWIVPNYIFGLPTDLYASRLLLWFPWQLTSRLFEPIMSLLLGHPEKYNLNPKMHLLQSQPTVSPTLIHHIQRGHIKVKSNIARIDGRTVHFADGSSAEVDNIVLCTGYHINLPYLSEELRSKVLDDSSNMIKLFKNVFSPAVGPSLAFIGFVQPASGGILSMSETQARWFAEICRGQVKLPGQEVMTSSIQEDTDAVKKRYTASARHTIQRDPIPYNDDLAARFGAKPQLWRHPRLMWRLLIGSGGAAQWRLNGPGKWDGAPDTVRSVPVTGLMHYGVLTIIGLVLGLLACIVLAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH69</accession>
    <name>A0A913ZH69_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleiotrophin/Midkine C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051132.1">
        <property type="nucleotide sequence ID" value="XM_038195204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH69"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195204.1">
        <property type="protein sequence ID" value="XP_038051132.1"/>
        <property type="gene ID" value="LOC119724238"/>
    </dbReference>
    <dbReference type="GeneID" id="119724238"/>
    <dbReference type="OMA" id="RTKPCYG"/>
    <dbReference type="OrthoDB" id="10024128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.90.10">
        <property type="entry name" value="Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.60.10">
        <property type="entry name" value="Pleiotrophin/Midkine, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000762">
        <property type="entry name" value="Midkine_heparin-bd_GF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020090">
        <property type="entry name" value="PTN/MK_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038130">
        <property type="entry name" value="PTN/MK_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020091">
        <property type="entry name" value="PTN/MK_diS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037122">
        <property type="entry name" value="PTN/MK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13850">
        <property type="entry name" value="PLEIOTROPHIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13850:SF5">
        <property type="entry name" value="PLEIOTROPHIN_MIDKINE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01091">
        <property type="entry name" value="PTN_MK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57288">
        <property type="entry name" value="Midkine"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037043139" description="Pleiotrophin/Midkine C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine C-terminal" evidence="3">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine C-terminal" evidence="3">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="388" mass="43754" checksum="6909EF9A1F447C05" modified="2023-02-22" version="1">MRKLLLLLMVLAICVAMVTAGKKDRERKDRRREGKKARPQADAAQPENPPTEDSRAPKHEQTPTQQPSNQPQASADSQRPSPADDRPNPRCSEWRWSACEVRHGRPCGKGVERATRDGENCKKKEQVRPCRVPCEAQDQGTARTEGEGRRKGGNNGEGRDRGASSQEGEERQRVPPKRQREETPPAPEENTEKCKYNKKDWTACDEQTSLQTRLYILKKGDPATCPAKKVITKPCDKYQRRLENKNNCEYVLGPWSLCNVTSDMRERHDTLIDQTKESVGCRLVRDIHQRCAVACVYGWGEWSDCDEEAGKRSITGTLVRENITPADCQETIARTKPCYGKNGTEKCFFGPWSGYGTCVNGFKLRTRKLLVGGRRCELRASHAIPCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK90</accession>
    <name>A0A913ZK90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="RefSeq" id="XP_038051744.1">
        <property type="nucleotide sequence ID" value="XM_038195816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195816.1">
        <property type="protein sequence ID" value="XP_038051744.1"/>
        <property type="gene ID" value="LOC119724662"/>
    </dbReference>
    <dbReference type="GeneID" id="119724662"/>
    <dbReference type="OMA" id="ATWMRRF"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000001">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="643" mass="73192" checksum="A6691031C4EAE907" modified="2023-02-22" version="1">MGLLSLGTPLSWEEIKANGYDEHIRRHGLIQFVNLYNKLKDRPCDMLKWGDEVEYMLVKLDHENKSAKLLLKAEEILPRLQEKEENNPGGDSNTLWHPEYAAYMVESTPGKPYGGLMAHLNTVEANMKLRRQELEKLLDTAKGETALTLTAFPRLGCPSFSTPWYKPNPSNDDGIYKSLFIPDETIYLGHPRYSSFTKNIRKRRGEKVAINIPIFKDKNTLTPFVEEFVNDHDGEGARAAKPDHVYMDCTGFGFGNSCLQMTFQACNITEARHLYDQLTPLCPIILALSAASPIYKGYLTDHDVRWNVIAESVDDRTPEERNLEPLKNNKFVIPKSRYGSTDSYLSPNGERYSDIDLVLDERDCQELMDKGIDRQLARHIAHLFIRDTISVFAEMIGLDDNKDSDHFENIQSTNWQTLRFKPPPVNSNIGWRVECRPIEVQLTDFENAAYVVFVVLLTRTILTFKLNLLMQLSKVDLNMQQAQKRNAILNSKFYFRKDLQSCACDCPIENEQCLMSINTIINGGPLGDGQGDFPGLIPLINLYVATVETDLDTRCTIMRYLKLISDRASGKLQTMAAWMRNFVTSHSEYKHDSVVTDRINYDLVTACDQITKGQMTAPELFHCTESKSSNDIPNSVKVAQEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKN4</accession>
    <name>A0A913ZKN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052367.1">
        <property type="nucleotide sequence ID" value="XM_038196439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196439.1">
        <property type="protein sequence ID" value="XP_038052367.1"/>
        <property type="gene ID" value="LOC119725078"/>
    </dbReference>
    <dbReference type="GeneID" id="119725078"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="227" mass="26239" checksum="96EA7D689DCB4ACB" modified="2023-02-22" version="1">MIPVRAYKRDAQNMTPMAHTEGIDASEKMVTVAVKPNSAPHVTYSQWDARAVGDIPDWRKRFDKAVRFFVLHWIPEETQALRSISACLKPGGQALFIIRFENRDDSFFLPRATSFLKSHEKWGAFVEDYKSSLHFWDLSVPETQKVFKACGWAEAKCEVWRHEQVLSEIQLKLFLDTCLGETPLIPAAALEDYLQDLWQWALDRYGDKTQPGHVLITLEFMVVHAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM86</accession>
    <name>A0A913ZM86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052176.1">
        <property type="nucleotide sequence ID" value="XM_038196248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196248.1">
        <property type="protein sequence ID" value="XP_038052176.1"/>
        <property type="gene ID" value="LOC119724927"/>
    </dbReference>
    <dbReference type="GeneID" id="119724927"/>
    <dbReference type="CTD" id="54859"/>
    <dbReference type="OMA" id="MFTELNS"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="268" mass="29317" checksum="84CE5DF264766773" modified="2023-02-22" version="1">MFLELNSYIGLDANDPPKGHLILATDSLTDGSFLVHHFLSAFLKGGHHVYFLALAQSFSHYNAVAQKLGVNLTSARDSGQLTFINGLDFSLQLMHAGINGSQEDELIAFQCLRDKTATIQPLYNVIRDALSPKQSEQGKSATRLLIIDDLSVLISLGLSVQQVMQFVHYCQASQPETTVVCLVHHDADVDDECNAALITQLRHRAHCLLQVQGLGSGYSKDVHGQLKIVKRDPSGTSANRNQPDKTLQYKILDKSVTFFAVGTSSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN64</accession>
    <name>A0A913ZN64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052809.1">
        <property type="nucleotide sequence ID" value="XM_038196881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN64"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196881.1">
        <property type="protein sequence ID" value="XP_038052809.1"/>
        <property type="gene ID" value="LOC119725474"/>
    </dbReference>
    <dbReference type="GeneID" id="119725474"/>
    <dbReference type="OMA" id="FITQWEF"/>
    <dbReference type="OrthoDB" id="5972388at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="296" mass="33016" checksum="80B90D801016D83B" modified="2023-02-22" version="1">MVDTLRAISTAWMVVCGAAIVSNVLAVILFAATKKLRVKYYGFAFNLVLGDIVAPASILLSFNANFPSALLPSLIGTSLCAVELSILAIAVNRFLALTITPPARYDAMVTRGRMLAACLLIWIISAAIFVPTGLHSQVTARMLHSSIVLCILLITAVFYCAVFRKISRYTPPLASTEGAWADDAVARTRLRQTRHLMITFTISLVTCFACWIPYCIVNFIGYFSIKGYSVLPINLMILSRLVITILTFNSLINPFIYWWRIREFRVSMYRLICRGRGNDDPENDVVTLQTMQEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQF8</accession>
    <name>A0A913ZQF8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proline-rich transmembrane protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053614.1">
        <property type="nucleotide sequence ID" value="XM_038197686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQF8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197686.1">
        <property type="protein sequence ID" value="XP_038053614.1"/>
        <property type="gene ID" value="LOC119726068"/>
    </dbReference>
    <dbReference type="GeneID" id="119726068"/>
    <dbReference type="OMA" id="VHANMET"/>
    <dbReference type="OrthoDB" id="6098146at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF44">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17329" checksum="F6971840F9DE4DA3" modified="2023-02-22" version="1">MSTEYKEFQNEADADDGANCPPTQPQPAQGDAPPQPEQGYDAPPPYNDPNHGAPGLNYPPEHAAPTMVQVVAPRPQTIISTTAVCQPNDYFGLALFVTFCCCLPLGIVGLIKSSAVRNRFMVGDIAGAEQASREAQTYSQYGLGIGIGFLSLNVVVGVVYAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQH1</accession>
    <name>A0A913ZQH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053629.1">
        <property type="nucleotide sequence ID" value="XM_038197701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197701.1">
        <property type="protein sequence ID" value="XP_038053629.1"/>
        <property type="gene ID" value="LOC119726085"/>
    </dbReference>
    <dbReference type="GeneID" id="119726085"/>
    <dbReference type="OMA" id="NCWMQAM"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036928349" description="Thyroglobulin type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="5">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="296" mass="33352" checksum="F41D1BD11FDC9BDA" modified="2023-02-22" version="1">MASLASMILPLLFSTILINVVIVKTEDTKTESPTEHGLGVKSGGEEPQITPGKSAPNTAGGLDPMAVWDKLMKDISTEQTRPRRQAGGGYNPIQKGRSSAAESPKRKYLHHLQRQGEQLKQKLGRHHFPKANSAKQGSLRARQWQKQKQDILKYQRNQQRLKHSKKSDLYGAGKGAVTGRRLPKSRVHFTPLGVAAPVGPIQEEKRMRRLYGKYFNDKDDEIKFSLPKRLLGNCWMQAMVGRLFKPSCNEDGTYSPKQCHRKRCWCSDKYGKPIKRSGGHHNEGFYQGIKALTLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR08</accession>
    <name>A0A913ZR08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054213.1">
        <property type="nucleotide sequence ID" value="XM_038198285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198285.1">
        <property type="protein sequence ID" value="XP_038054213.1"/>
        <property type="gene ID" value="LOC119726553"/>
    </dbReference>
    <dbReference type="GeneID" id="119726553"/>
    <dbReference type="OMA" id="EHASHRD"/>
    <dbReference type="OrthoDB" id="10060767at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="459" mass="49548" checksum="D51C92CEB975A259" modified="2023-02-22" version="1">MSVMTSQRHTTGHSATRPTNAPGRGRCTTIAVASFFVMFLISTMMRCTGILFLSWQNAFDASAVQTGGISSIVTSTVFLGSALSGVVCNRFGYRFTCILGGFLTSFAMFMTPWASNLIHMYTLAFFTGLGISLCYMAATVAVADYFRKYYAQVSGICMAGSSTFMVVSPPLFHLLLDAYGWRGTMLVAAAMCANLCVAGALYRSLHGSKVDDCNPNRDERLSEGQNTHQQVQVRSDVHKLKRLSLVGFLKGVFSAFKLELMLKSYRFSLLCLTCVELQMIYSCSVIFLVPRAQISGIDELKASFLLSMFGFGSLGARLSSGFFVTRKTPVEALCTCSFVLCCVGLLCSQAETYESFAASACIVGMCVGATTAWNNILLRKLVGLRHLASGQAIMLLFSGVGNLIGPIVAGLAYDSTGAFSTVFYVLAGLGAAAALQMLLMPLLRRIESGIDEERETPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR91</accession>
    <name>A0A913ZR91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine aminopeptidase 2</fullName>
            <shortName evidence="12">MAP 2</shortName>
            <shortName evidence="12">MetAP 2</shortName>
            <ecNumber evidence="12">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="12"/>
    <dbReference type="RefSeq" id="XP_038054288.1">
        <property type="nucleotide sequence ID" value="XM_038198360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198360.1">
        <property type="protein sequence ID" value="XP_038054288.1"/>
        <property type="gene ID" value="LOC119726614"/>
    </dbReference>
    <dbReference type="GeneID" id="119726614"/>
    <dbReference type="CTD" id="10988"/>
    <dbReference type="OMA" id="GNGWVYD"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000003">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="15">
        <location>
            <begin position="183"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="493" mass="54211" checksum="523532916FE6967E" modified="2023-02-22" version="1">MATTMAEKDSDIKADLEEEVVDNAEAGTEKKKKRRKKKKTGGSAVEAEGHLPVTNGEVDKLTDEVKKQSLGNDEEKDAEGEGDGDTESNKKKKKRKKKKGGAGGNQGGEGEKSSENGVGGKSGGAARQTDPPTIPVSQLFPDGVFPEGQIMEHPEVDGRTAAWRMTSEEKKALNMAHNDVHNELRQAAEAHRQVRKYVQSYIKPGLTMIDICERLETASRKLIDENGLAAGLAFPTGCSLNHCAAHYTPNAGDSTVLQYDDVCKIDFGTHINGRIIDCAFTVAFNPRYDQLLAAVKDATNTGIKEAGIDVRLCDVGERIQEVMESYEVELNGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEENEFYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPLRMPRAKLLLHKINANFGTLAFCRRWLDRIGETKYLMALKNLCDTGLVDAYPPLCDTKGCYTAQFEHTILLRPTCKEVVSRGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS79</accession>
    <name>A0A913ZS79_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-sugar pyrophosphatase</fullName>
            <ecNumber evidence="8">2.7.7.96</ecNumber>
            <ecNumber evidence="1">3.6.1.13</ecNumber>
            <ecNumber evidence="7">3.6.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">8-oxo-dGDP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nuclear ATP-synthesis protein NUDIX5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nucleoside diphosphate-linked moiety X motif 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32063"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:63715"/>
            <dbReference type="EC" id="3.6.1.58"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:50248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="2.7.7.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Interacts with PARG.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.96" evidence="8"/>
    <dbReference type="EC" id="3.6.1.13" evidence="1"/>
    <dbReference type="EC" id="3.6.1.58" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038054254.1">
        <property type="nucleotide sequence ID" value="XM_038198326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054257.1">
        <property type="nucleotide sequence ID" value="XM_038198329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS79"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198326.1">
        <property type="protein sequence ID" value="XP_038054254.1"/>
        <property type="gene ID" value="LOC119726592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198329.1">
        <property type="protein sequence ID" value="XP_038054257.1"/>
        <property type="gene ID" value="LOC119726592"/>
    </dbReference>
    <dbReference type="GeneID" id="119726592"/>
    <dbReference type="CTD" id="11164"/>
    <dbReference type="OMA" id="NDPGLCN"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="14">
        <location>
            <begin position="63"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="230" mass="25834" checksum="9909B9D330D22EED" modified="2023-02-22" version="1">MSSEGTSSSPTNNAHKPKSEFIKQETIHREKWLSLEKITYKDPRGKIRTWETVERTTKPQRPGVADAVAMATIVKRLLHYDSILLVRQFRPPVKCYTIEFPAGLVDSEETVAEAAIRELKEETGYVGTITSISPVTVMDSGMSASTLNLVFVQVDGDDTVNQRPVPNLDEGEFIEVIHAPLHELKQKLDAYSEAGDLVDSRVYTYAATLHQCQHKGEDMDLEQQKGLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTN7</accession>
    <name>A0A913ZTN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054431.1">
        <property type="nucleotide sequence ID" value="XM_038198503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198503.1">
        <property type="protein sequence ID" value="XP_038054431.1"/>
        <property type="gene ID" value="LOC119726703"/>
    </dbReference>
    <dbReference type="GeneID" id="119726703"/>
    <dbReference type="CTD" id="51384"/>
    <dbReference type="OMA" id="NCTIHDQ"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19344">
        <property type="entry name" value="Wnt_Wnt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF70">
        <property type="entry name" value="PROTEIN WNT-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037184647" description="Protein Wnt" evidence="10">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42639" checksum="997FC1709B3A5D5F" modified="2023-02-22" version="1">MDVTTLRCCEFSCLILLCVLPATSRASWMWLGIASLGTVNQPNDLGLPASSSSNPVLPRPTSPGESVCSLVPGLATEQRAVCERRPEAIPVIGAGARLGIAECQRQFREERWNCTIHDQEQNAFGKVLKTGSRETAFVYAITSAGVVHAVTKTCSLGNLTDCSCDDSRNGLVNSEGWQWGGCSDNLDYGITVGRQFVDAAEVRKGEEEEGKANRVRSAMNLHNNEVGRQALRQFMSRQCRCHGVSGSCTIKSCWNTMPDFLAVGDYLKNRYLQSIEILNRPTKRRLRRKDRGMRKVPIAQDEMVHLERSPNYCVRDASRGIMGTTGRECNRTSSAADSCDLLCCGRGYNTQEVRIVERCDCKFIWCCEVKCRVCETITDLYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU73</accession>
    <name>A0A913ZU73_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054775.1">
        <property type="nucleotide sequence ID" value="XM_038198847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198847.1">
        <property type="protein sequence ID" value="XP_038054775.1"/>
        <property type="gene ID" value="LOC119726986"/>
    </dbReference>
    <dbReference type="GeneID" id="119726986"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="101" mass="11861" checksum="D2A2540353081C3A" modified="2023-02-22" version="1">MKMFHPVSIGLQFHHVFENEKAIACNLLKAPKLEWLPNPEEDMVMELELQEEEEQDEEIEEEDLKSDVDYVPSSDSDDSPWEMDSTVETTDVVDERKFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUF3</accession>
    <name>A0A913ZUF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054706.1">
        <property type="nucleotide sequence ID" value="XM_038198778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198778.1">
        <property type="protein sequence ID" value="XP_038054706.1"/>
        <property type="gene ID" value="LOC119726934"/>
    </dbReference>
    <dbReference type="GeneID" id="119726934"/>
    <dbReference type="OMA" id="KERCELF"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="537" mass="60450" checksum="4594DE2E1EF33E5F" modified="2023-02-22" version="1">MDCDHFLCQECQKAHGRMTLMKSHKIYTLAQLQSGQIVYKSKLRDEVPKCCKHPDQNLNVYCNSCERVICTTCSVLDHAKHSLTGLPEAAEKCKKKVTDMVRKSENRKTEMSSTIEETCKSRKELDTMFANAQKKLSKKAKEEITKIKLEVARIELGIPKIQKEEQKLKQEMDRIYQHRVRTFEAAQATNRKEVTQTEHKLEEVKQLMNQASCCEILELQQKLLHNLGELTGKQPQQVPDKLTFMDFEEGERSLGRLILEEEPQAAARSCVKEKWELKTEVKNFELRNAFIAHVASLSSNKIFVLSKNYTGNSGALFTASIPTSYQEPSPIPQRLHINGLTDDVRCIAVSKDGKLFVLDGPEVKVFNKQHQLLHQFTPGRGSDSQPTCLAVDDSNLMAVGYKGQNEISLHNPDGSLIRRMSVPMIGNYLTVYNHCLIYTSWKNKMLVCVDYYGASVFSVDISIQGGWYPNGVCCGSDGNIYIAVGGYSTGFILHYSPDGKYIGCVIKGCGRPRGTTFTSDGDLVVAAEQLVKVYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVE2</accession>
    <name>A0A913ZVE2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein cramped-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055517.1">
        <property type="nucleotide sequence ID" value="XM_038199589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199589.1">
        <property type="protein sequence ID" value="XP_038055517.1"/>
        <property type="gene ID" value="LOC119727627"/>
    </dbReference>
    <dbReference type="GeneID" id="119727627"/>
    <dbReference type="OMA" id="YLMMGCP"/>
    <dbReference type="OrthoDB" id="515799at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124149" checksum="9327ED5EF55AEC86" modified="2023-02-22" version="1">MVKRRKEPRGDEAPASAAKKGVQVQSSTSEEVNSGEKSPDLEEPAEMKGSHIEGVSAPENGPAQQPDMSADEIKQEQPAPAAKPPLNHPFLRSSVKRKKKEPTPPPSPPKPDETEKAEAKPDRKRCWEAWSDGETTLFFEAVNEYGKDFDAIQKYIEQRHKKLGLAAHQIKNKNQVRHLYYRTCHKLFSFVDPKPDQGKTFSELLALVNFGELRKKLSLKGGITRKIGQKLNLLVTNGQTLIRVKGQNRRVKTPLCKALRKLKGDENKSEPYKLPAHVLMELQPKNNKAWASVQGTAHNPRVRLVISLKKNLSSIISYLNDKWTPYNSKLLNTLKPTDDVKNSLRLRLLLSEGVEVTPHNQVTGRYMHSDSRAVFSLDTEARVTKAVAASKAAKIQRAAAAPSTRTPSGCSLDCTKDVPGLDKTADKGNCDSNTLAGKPRKYKPRKKAKLAKIDECSNEAGDQEVQPVPIITSNHRRKSEDSEPMEVTKSDSSKSPIKEEANETEKMETEELPEVKSEMETIPLEEMQWTVAPEKEITKDEQLMGELSAENSKNLTMTDIYLMLNMPTRLKFEYEFVKEESGSTDDKPRNESKLLHKLLALASTEFTDIRKPRRSISVGTVTSPPRFNMMPGNNTTPPSKASFISQLSKSPGTPRGGRNATSNGLMRVNSRPVGKPTGTGNAKDKDNGVFLKPAVPSSQQQHSASMESSTTAAEKLFMAQIESLQKQPFLKPNNRRGRKPLVVQRTLLPRPLCEHKGPTRHMMSMSKTGQFTPVQLGIPDSVSQKTIVRPVPIAPGPASRGLPSSSASSKASMPSSSDRTNSPILAYAASPIGSPGQSMVASPLNASSPVSSLAMATPTSLLPGGVAPMNEIEAASAAAGIDTTLRPSPPEHTHPPTASPLPMDTTSCIAHAGPAKTPMLNPSPQIIDDTMEIVSVTPSTSFDTSETGGALDTVGTVGQTFSIPAPNLSSLLDISLPSSAAAGAGDSLMDIPIGSASFTGFNQQLSPNTSNPSVMLPSMSPVRESGTTTPPLHLTSPSSSPFKLNSLSLDNQWLNGENADISYSSILATLESPEKKDRHGSGSLTIPQPSLISESSRDSTISKDVDAHLQFMMNENSVDYVAKFADLAAHITAQQEAQKETTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW28</accession>
    <name>A0A913ZW28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055724.1">
        <property type="nucleotide sequence ID" value="XM_038199796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199796.1">
        <property type="protein sequence ID" value="XP_038055724.1"/>
        <property type="gene ID" value="LOC119727750"/>
    </dbReference>
    <dbReference type="GeneID" id="119727750"/>
    <dbReference type="OMA" id="YCRAAQH"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032447">
        <property type="entry name" value="Cyclin-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16500">
        <property type="entry name" value="Cyclin_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="9">
        <location>
            <begin position="322"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="326"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49533" checksum="028A2D15D5C95BCC" modified="2023-02-22" version="1">MSFAFSENPLTYDVENSQNAGPQTRKTKREDAGRGNGPQACKRAALGTLSTNVTRKQPSRAAKQSGFADGFYNYQDENAFARPAAGKSTGSCGFALPPTASQPSFSIHIDPVEPAPPRARFLKEQKPTELPLDPIVTSLPEVERQPLRTVFTLDESASPMVLDTSLSEENTAPATIEDIDNSDGVFGVPEYAEDIYEYLREAELRNRPKPGYMRKQPDITSGMRSILVDWLIEVGEEYRLHNETLYLAVSYIDRFLSQMSVLRSKLQLVGAASMFLAAKFEEIYPPEVNEFVYITDDTYTVKQVLRMEHLILKVLSFDVAVPTANAFLSRYLKAAKADSRMEHLARYLAELTLPDCEYIKYIPSTIAAAAVCLANYTLSGTAWTPMLAKHSGYNLEDIAPCVRDLLKTFTNAPSQSQQAAQEKYKSQRYNSVSMIVAPTTLPSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWK6</accession>
    <name>A0A913ZWK6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055907.1">
        <property type="nucleotide sequence ID" value="XM_038199979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199979.1">
        <property type="protein sequence ID" value="XP_038055907.1"/>
        <property type="gene ID" value="LOC119727901"/>
    </dbReference>
    <dbReference type="GeneID" id="119727901"/>
    <dbReference type="OMA" id="NFDERCA"/>
    <dbReference type="OrthoDB" id="2126785at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="492" mass="57123" checksum="EA3456541693F972" modified="2023-02-22" version="1">MESPADFYRHVLTEVLDDLMDQVGGLTKIEKVKKALRKISQMYKGGLSNASSQCRSDWSDPANRCAYVFLYLMQHCHLVFSSLQYTSKILNSWQNKSNLKICSIGGGPGSDLVGLTTFLRKKGIFPPLLECLVLDLYPNWKDTWDMIYKRIPERFGVQYKRCDIVRDTALTSISTRRFIRDADMLTMVKFFSTVSAFFRDEPGCGDLLRSFLHELKPGCFVLFIDNQHNSDTQFEQDFASPIGLGKVFEFRGKSTLPFGQYSSTVKRYCRDLNYKPMSSCEVLIQLYKKLAVQPASRSCVISQDRNNRIPLQHSGSSVDRIQPGAHHRNNVDDRLSSSSQPRYSSLPAASSRSLVLHDFANRRHVPTSPVDGDSDSSYDNSDDDNSYEYDSDDRDYDYDDYDSNDCYDGYGDYDCDDDYDSDDNRNDCYDGHDDYDNDDYDSYRYDCYEEYDYMYDKYYGFDDKKDRYDGCHEYDCDDSYNDYDDYDRNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWY1</accession>
    <name>A0A913ZWY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056029.1">
        <property type="nucleotide sequence ID" value="XM_038200101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200101.1">
        <property type="protein sequence ID" value="XP_038056029.1"/>
        <property type="gene ID" value="LOC119728019"/>
    </dbReference>
    <dbReference type="GeneID" id="119728019"/>
    <dbReference type="OMA" id="LAFHRVC"/>
    <dbReference type="OrthoDB" id="1917888at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033333">
        <property type="entry name" value="FANCB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28450">
        <property type="entry name" value="FANCONI ANEMIA GROUP B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28450:SF1">
        <property type="entry name" value="FANCONI ANEMIA GROUP B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="928" mass="100894" checksum="140C3EC9EEF0D9CD" modified="2023-02-22" version="1">MSVPAVYTSVHGKLVKISSFPGSQMQIDTPLLQNGTSDAMAMETMDSEATLLAESFQFSPRSGKFEPRGDRVTHTLGNGTDIRLLALAKVTDSRTGLKIPCLVVEQRVWEKYNVPVSAAGDGAGISKISKYRSRVSVVFLLLRKKTFLLRGFFTLGYSLKSTKLFLGNGPTLCWEHQRSVYFTRAFGSSNQTKVSVDDVKLDEDLSKPSKSLKWFGVVSGDAVAMGTEQSSNHEHSAGKMLLNLGHRWTVVKLPVHKTEERNVPIAEEIAPMPHEYSNIVNCLHFCQGSVSQLGSSFFRNSDRSVDKGSSLVLAATNQSQLVEACGGMVRRVCSITFNDACKIAIATVTGGEELILVQSAGGRVCAVWRKTFEVAREWTGFYTVLVDDFLFSGSEQLLLLGDGADAPQKRFHLTDLGMCNWSSEENGNTITDGPPVCAGNLQSAVQALESQVQTGMAALRSLESQCALKAQLIKQSQDALFKMAERTPPLPSHDTSLTCLCDLSGEDNTDVVGEETPSTDEDTTLECLSTWQRVADDRWIIGAEVANTTDRAISDVCISLIPASTPQTSLHSSTSTCNFKSVVSSAVASDHGEPMAKRIKLDQDSRTAVLESRAKTTVVGVTGVPEFVSEPVVTCTVVLNWREPFVRNHNDVVTAEENKARPGVDKDGFVDRRRACGTASLQACDVASGKLLINPLDRKKSDSERRHDIQALDALQLATPLLLTSNHSNLQCVKCTLKGPMGFQDVTMHDGMISAAGALGTTRVKIVSRDGPNKMAINVWSRNQSDLLLFCQHLYQQLPDDVIIKPLPPANQIWSAMGTTMATIDKELKHTSSKMQQLLATSSLSIVQGHDAKATTSNGANAGPSGEDKLKQVRGDFEGERRKWCNSDARLEVCASDKAHVLRQELLDLRINTDTDASNLASVFSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXU6</accession>
    <name>A0A913ZXU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056140.1">
        <property type="nucleotide sequence ID" value="XM_038200212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200212.1">
        <property type="protein sequence ID" value="XP_038056140.1"/>
        <property type="gene ID" value="LOC119728138"/>
    </dbReference>
    <dbReference type="GeneID" id="119728138"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="140"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41832" checksum="8EDCB2B203D38A9A" modified="2023-02-22" version="1">MTNVVYTFRDPTGNSAGCAFVVNVIADTRVPVITGCPTAVSGVAPSGSTTGTATWDEPTAADDDNLPVQLARSHFPGSLFPIGGTTVRYVFMDSAGNQAICSFVVTITSAFGATNLPRTTPLQGEDDMNPTTTTGDVVPYNITSAIVISVLSTLLTILVAAIVIYAVRRRVKLLKRSRRHQADNSDRANFLAEFHAMTIVGSHPNVVSLLGACRYQDVLYVALEYAPNGDLLSYLRSVRSAPDGGVMSSDQLVKFAFDVAKGMEHLSKTGLIHRDLAARNILLGEDLVAKISDFGLSREGDIYVQTSKRPVPVRWLAIESLVNQSYTTQSDVYALMTQCWYEDPNRRPSFSDLTQILGRMTDNMSPFVEGQAYYVNAITPELDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXV0</accession>
    <name>A0A913ZXV0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056473.1">
        <property type="nucleotide sequence ID" value="XM_038200545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200545.1">
        <property type="protein sequence ID" value="XP_038056473.1"/>
        <property type="gene ID" value="LOC119728342"/>
    </dbReference>
    <dbReference type="GeneID" id="119728342"/>
    <dbReference type="OMA" id="CIRECVS"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031985">
        <property type="entry name" value="DUF4787"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35455:SF1">
        <property type="entry name" value="AGAP005842-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35455">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16029">
        <property type="entry name" value="DUF4787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037181368" evidence="1">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="119" mass="14100" checksum="1D2A065F75857AEB" modified="2023-02-22" version="1">MGFCSSESRYKIVVLILFLLLFGECFIVCVEGQRVPYVFARYPFKKKPKNERQFKISIRQCEQNPDCSQMQGLDMTRCARKCIAPDCYQELYAHDELELGEIDVRATSFRGCWVQRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ53</accession>
    <name>A0A913ZZ53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056605.1">
        <property type="nucleotide sequence ID" value="XM_038200677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200677.1">
        <property type="protein sequence ID" value="XP_038056605.1"/>
        <property type="gene ID" value="LOC119728437"/>
    </dbReference>
    <dbReference type="GeneID" id="119728437"/>
    <dbReference type="OMA" id="YCTPLEH"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="182"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37562" checksum="238389517CA6EFB5" modified="2023-02-22" version="1">MATHKTADAYPATGMEVNKAPERGSMAGSIRMLVVITTSILVVVIAAKNSLTWLLDQFLLASGCFWTRQYEVIYNLFGGNEFLILSLGTLLVSTVVYWTLASGCLFVDATGKPSWIHKYKIQQDKNIPVDPALLRQAVTGTLFNQFAVGLPFLLVCAWLSRMRGCSASTRLPEFHSVLLEMLVFLAVEEIGFYYLHRLFHHSFFYKRFHKRHHEYTAPFAVSNFDVHWLEHAVANLAPMAAGPLIAGSHVATTWFWLTIGTFSSLLAHSGYHLPFLPSTEAHDFHHLKFVNNFGALGILDRLHGTDAIFRQSQNFQRDVLLTGFTPASELGTAKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0L7</accession>
    <name>A0A914A0L7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057375.1">
        <property type="nucleotide sequence ID" value="XM_038201447.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057376.1">
        <property type="nucleotide sequence ID" value="XM_038201448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057377.1">
        <property type="nucleotide sequence ID" value="XM_038201449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057378.1">
        <property type="nucleotide sequence ID" value="XM_038201450.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057379.1">
        <property type="nucleotide sequence ID" value="XM_038201451.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057380.1">
        <property type="nucleotide sequence ID" value="XM_038201452.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201447.1">
        <property type="protein sequence ID" value="XP_038057375.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201448.1">
        <property type="protein sequence ID" value="XP_038057376.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201449.1">
        <property type="protein sequence ID" value="XP_038057377.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201450.1">
        <property type="protein sequence ID" value="XP_038057378.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201451.1">
        <property type="protein sequence ID" value="XP_038057379.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201452.1">
        <property type="protein sequence ID" value="XP_038057380.1"/>
        <property type="gene ID" value="LOC119728977"/>
    </dbReference>
    <dbReference type="GeneID" id="119728977"/>
    <dbReference type="OMA" id="NADNIWF"/>
    <dbReference type="OrthoDB" id="2162143at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028928">
        <property type="entry name" value="CC2D2AN-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041510">
        <property type="entry name" value="DUF5523"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15625">
        <property type="entry name" value="CC2D2AN-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17661">
        <property type="entry name" value="DUF5523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1696" mass="194232" checksum="5BC74F5CDC0DE2F2" modified="2023-02-22" version="1">MSTSTLQQRIMKRRKDLRESMTPTMDLEMTQSTSRNGTVAMEHDGVEEMETIVDPMEEIREAENLVEKLTSNREKKLKELSSALEPIDDSKQTPSKAPRRKVKRLAPEREIETIPEQLGSREDDVGQQEEGEMGDEGKGKKRKGKARKDSKEPMSMEEAVIAAQTGVVMPESSKNLNASIRERIKMRVMKAKEKAEEKEREEVEKDPEKDLPSRLLRGLRARDMATRFDDPSFLTKEEEEEDKILQQSLAAKSKWKAAFKAIKAQQSILPSEDEIYDFFTRNFDPEPEEPPKPTEEDDVPPEDQPGPSTAPQATEGQAEPPAGKTTAGSKGKKEGEEKPLLSEFFLDRENWKDFPTEMKGPEFIALRDREDLEKGYYFIPSVAAIPAEEKIVGDAEPRFLEDEGFYVGVRPEISTRNQNVMEHRLLNRPDKGKEWFGDDGRIKVLPDPLKETPTRPKILSNEEREPFLQVVYKKAVTTEFDHRYIDGLGDNLRAQYQLDIDVNMLVFTHHSLFSKEHVLASKLQQMYNQFLKSKQKNTAQYLSEKLQALKLAVHNLQSQLQDLKSRKMDPEASIVDQSSQRMMDYKNEIRDVRRLRDNQLLHDRQLLRNILKVWKDVKALREEQGCTNTPVKLSIHKEESNKVLDQAEWKAALEEDVEEMRLEYEEDHQGEMERYRTQLAAWKEQNKLKKAKKKKKRQGSQENLAEQDEAEEDANEAAQIPKPVKPDYEFNEEEASAKVTEKMYKCRRRPGEPIITPELNNTAVITPTHECPKTEQSRRSDVQRCKCFVKVLFNHKEVSRTATKSLTAEFTIHFGEIFNIQIVQWPESVILQVYETGVLSNTLLAEIYSAVPETQVTADKIHLEEFEFSSDQHIAYDHSAVGSGVSFQLGGGDSAQELTLLTSGVLMSSVAWGLGDDETPLVPPANQNTNALSAVKHLDAVAAIGATGMIDPERLAKWVAEARLDPNDPANANLLYLMKDARAEDGQGYRVPDFFRLEQLQEEFNFMTDAELAALKRLRLIELRQKEAPEFRNYKMIPVLEKEIPDTLITEYEKRKKKEEEGIVEEDMDPHRVAVAKFLGKVRERVIARFRAAQHQYSLQDVVNEEQVPDISMLGGTLVKLFEPRRPLRPQRKERKTVTAQNLSGLDVRLLVNIERAVDIPIRRGTARQAGTGQTQSAPQVRPFVEITFQQTVQRTSVTEGPNPNWNEELKLPFIAPNDDYSSANLQTVKDTIYIHLFDEVVTDLLEDDRDRGTNIHQRMERRWLGSISMPFTTVYFQGRVSGTFRMEAPMVLLGYDRSSENVNPGSANATYLTLFITIEPPLTSPEKLKEKFDSNEDDKLLAYAESYQTESLAKFPKRELVTTVMDINGKAVFITRYFRPIKPPDEVLGDNVGVKAAERVARFVSLIPFVSDSVVYPGLCDIWSTCDQFLQMLQGDEEEHAVLLCNYFLHLNKKAWLISGAAIPEGPTTYVLTREDGVSGSGGYWVWNPSTGEHYSQFDSFCPLKSVGCLVNHENIWFNIQLHEEPIRIDLDVTKAKMWKPFFGRSYPNPGLSSVQPTELNYYQTDREYVADLQDKIEKKLRDCIMAWRPRHITRWNRYCTTVFRKILRKLEFSHAGTDEHQGELQQILDSYNLCGFPLQMSYTEMRTVVEKVRSTNVHANESSDVEFGLAVHIHAYPNSVLSVWVYLASMTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1B1</accession>
    <name>A0A914A1B1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057429.1">
        <property type="nucleotide sequence ID" value="XM_038201501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1B1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201501.1">
        <property type="protein sequence ID" value="XP_038057429.1"/>
        <property type="gene ID" value="LOC119729017"/>
    </dbReference>
    <dbReference type="GeneID" id="119729017"/>
    <dbReference type="CTD" id="8667"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="38752" checksum="432A8DED5130581A" modified="2023-02-22" version="1">MIIVHSVINFTKMATASTLDAPVARVQIDGLVVLKIIKHCEEEGGSAGELVQGVLLGLVQDDTLEITNCFPFPKHADEENFDDVLYQMEMMRNLRHVNIDHLHVGWYQSTLYGTFLNKALLDSQFNYQHSIEESVVLIYDPLKTSKSTLSLKAYRLTRNAMESYKDYDFSTDALKKTGLCYENIFEEIPIVVHNSYLINTLICELKEVTPPTGDNFLTLSSGNMLEKNLELLMEHVDDLAQETNKYMNYQRAMTKLQQNKQQHTYKRQQENAARQQRGEPPLPEEDLSKLFKAPQPPLRLESMLMAGQMKNYAAEINRMAASSFGKLFMADALQTPGPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1T5</accession>
    <name>A0A914A1T5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEK-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057605.1">
        <property type="nucleotide sequence ID" value="XM_038201677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1T5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201677.1">
        <property type="protein sequence ID" value="XP_038057605.1"/>
        <property type="gene ID" value="LOC119729149"/>
    </dbReference>
    <dbReference type="GeneID" id="119729149"/>
    <dbReference type="OMA" id="MIKKAPT"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="6">
        <location>
            <begin position="421"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="477" mass="54182" checksum="35781508E5F54830" modified="2023-02-22" version="1">MSDTENNEVEQDVGGDMEEENPVEEDKPQDEDRTDADQSIESTSSPASSSTKSPAKSTSSPKKTPQKRKADQNGEGETKDEEESDDEDESSDEELVGLLDGPVQLMTGKRERKKTERLTFDTKKEAVDTKFEVEEGRGTRLGDIPNVEYYISRTNSENFRAIYRFLLGRTGKAHEIKKNIRKFSGFNFDKDSPEYTKKEATLVRYTMEGLKEVCMWLDLDKSGNKEKILERIMDFCLKPEPSGRPHPQKKRKPKVVKKKGKKRKRKEDGSGDAKKAKKAKKSKKSSEDVDADEENEEDVEEEEEEEEEEGAESAEGEDGDDEDETQEPKKKKAKLDKPSPQKKVEKKKQEKKKQAPKSPKKSPKKTPAKKTTPKKTTPKKASPKKKASIQITPKSKSKAKPLTIEDSDDSSDDEPLMRKAEPSEDQIEQTIKTFLEKADLELVTMKMVCRKVYETYPDFNLAHKKDFIKATVRSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3Q1</accession>
    <name>A0A914A3Q1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038058204.1">
        <property type="nucleotide sequence ID" value="XM_038202276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3Q1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202276.1">
        <property type="protein sequence ID" value="XP_038058204.1"/>
        <property type="gene ID" value="LOC119729630"/>
    </dbReference>
    <dbReference type="GeneID" id="119729630"/>
    <dbReference type="OMA" id="QYEFQMW"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.430.10:FF:000002">
        <property type="entry name" value="Dihydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="21818" checksum="11C372653E618783" modified="2023-02-22" version="1">MAGQKQYNLIVAACKCKDSLGIGINGTIPWKLRTDMKFFSTQTSTTAEKDKKNAVIMGRKTWLSIPDKFRPLPNRVNIVLSKTLSECPAGADHLCRSLDHAVKLLSDPPVADGIDVVWIIGGSSVYKEAMESSLCHRIYLTRIHSQFECDTFMPEIDTSKFKVVSDPAVSGERQKENDIEFNFEIHQNIQHTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4B8</accession>
    <name>A0A914A4B8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058535.1">
        <property type="nucleotide sequence ID" value="XM_038202607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4B8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202607.1">
        <property type="protein sequence ID" value="XP_038058535.1"/>
        <property type="gene ID" value="LOC119729818"/>
    </dbReference>
    <dbReference type="GeneID" id="119729818"/>
    <dbReference type="OMA" id="IECIAST"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="622" mass="70663" checksum="6265C647CF1EEA30" modified="2023-02-22" version="1">MATGVTVESVLGSIQSHLECSICHTRYQEPKMLDCSHSFCLRCLQELKQSQTPDDGKITCPLCQRQTILPEGGVTKLNKNYTLVSLVDEVSKQEQILKGGETEGPAVVVCQACDEEHEATVQCIDCEQFLCRECHQAHLRFKSMKTHKITVLLNQRDDVLQTETKKNASNCDIHPSQKLCLYCTTCEKLICKECMVSGHKDPMHMRVDVNVAFDRCLKEVHKTYGKVGRFDTHVSQDWEYSRTRLSRMLVETKRDISSEAVSKVAEIRRQEMQLLQEADAVFMRKDRRLAELIFAQHAMKKTDGEITDRDRLEILKLRQDLLSEYKDVKEKTWEEVNSHLSFIPCKEKCHEIELGTLKLEEKWKLMKAFEATGSSVATFSTGNIAMAYGKRITILGLNDQEEYYIHESKETHLLNNPSGMAVTMDDVLFVANNDGTINKFNKEYQLLQQFKPSQEADIKATPTCIAVDNSNLIAVGYGSKDKISLHNPDGSLIRTLPAPMIGDYLTISNKQLIYTNKDKKKLMCLDYHGNNIFTVDSFENSAPHGLCCDKAGDIYVAAYCQCIGGVKESEYQIHRYSAEGIYIDTSVKHSLSRSWPIRIAYTPNGRIVVIGCYNLTKIYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4E0</accession>
    <name>A0A914A4E0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058717.1">
        <property type="nucleotide sequence ID" value="XM_038202789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4E0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202789.1">
        <property type="protein sequence ID" value="XP_038058717.1"/>
        <property type="gene ID" value="LOC119729998"/>
    </dbReference>
    <dbReference type="GeneID" id="119729998"/>
    <dbReference type="OMA" id="IEMAEWH"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770783" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38497" checksum="BC0DA23F752D5809" modified="2023-02-22" version="1">MEKPCRSCLNGPSNKILMIVMIFTFLVHVDAFQRDRCGNVKQTFFSADNRALQTSTLREEQFKSAVRCVSYCHADNNCRSVNYHRPDQLCQMNNLTRLQNPNDFITHYGSVYIDNDADTSLFSVPQFRGCDEVLQAGHNVSGIYTIFPAGFNDGLQVYCDMETDGGGWIVIQRRQDGSVDFNRNWADYQVGFGGLSGEFWLGNDNLRSLTETEGKWQLRIDLEDRENNTAWAEYDDFQIHGDNYTLRVNSCNIYSTAGDSLTYHNGMMFSTKDKDNDTNRMKFCAKLREGAWWYKNCYESNLNGRFRPGTTRDVPEHCPAKPVYRCLGYLSLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4E9</accession>
    <name>A0A914A4E9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058570.1">
        <property type="nucleotide sequence ID" value="XM_038202642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202642.1">
        <property type="protein sequence ID" value="XP_038058570.1"/>
        <property type="gene ID" value="LOC119729849"/>
    </dbReference>
    <dbReference type="GeneID" id="119729849"/>
    <dbReference type="OMA" id="YEQNISG"/>
    <dbReference type="OrthoDB" id="10132686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="536" mass="57662" checksum="D5C92EA2E50C7E12" modified="2023-02-22" version="1">MVLFGRNYTFGSGIVTIVLWMVISLVSTTQPVDTSQANKRKRRGSDEWVPPVVQNFCPCFFKRISGVVKLVTAYQSLHVEDIFRSPSLNHVFSDGQQVYFTQSPCPTTIAPTSTTLPPTTTSTTAHPTPTSPTTREQATTFAPYTTTDEATEGGTEMQMTASPGPMPLFIQYWLPALLGLLLVILLVALFRRRRRSRQTSAELKLRSETRSAGVYYSPCSDSGPLDVNPTGEVTIGDAPTLLNPSYERNIAGTELERSGDFFCPPMSDTPNQLKAKGRVRSPGHPGEVHGNPPALLGNFNVAFSEGNYSDVSPEQASSEHSPIPDAGYDNPGGFVGPNGGQTEPLKHPRKNPKSQPGHGYEEPMCEGQRSPFEGAHNPVAYEVASISPRGSLSTSPNPDTSYEVASINPAGQLEAAPRYTKVDKSSGVLGPVSGEKSPGADSGYEVASISPGNSPASASAKLRYDYAYAYTSPAGYPPGKPSQVNQYNVVQPQCKEGDGEYSMLSRNKGEGYPTSPTVPIIMSVNEYNTIHIPSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6H3</accession>
    <name>A0A914A6H3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059084.1">
        <property type="nucleotide sequence ID" value="XM_038203156.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203156.1">
        <property type="protein sequence ID" value="XP_038059084.1"/>
        <property type="gene ID" value="LOC119730318"/>
    </dbReference>
    <dbReference type="GeneID" id="119730318"/>
    <dbReference type="OMA" id="APWHKLE"/>
    <dbReference type="OrthoDB" id="70142at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1379" mass="154778" checksum="E20B844E2393D9D1" modified="2023-02-22" version="1">MGSKAGPIQPLEGMLSEQSRYRPFNLYWLDSALHETLLPGSPWEQVHAHICAELARSLRSDLGNLEEERKQMILHLLGPEFVKRYMPGVQHRPDVLDPSVLGVELKKQLQRTTQLLLRDKLDSIVRELGYAPASSNASTPVTDRQHSEDGHGDQGVSDIQAVIDHARGIFETGLERNLVIQEVIEKQEPQDVEDLPRSGVNLSGRTSDHLGRSLITILQRDPSRLDSICQRLSGKQLPATLRSYLWAEILLQLVEDGGSGREKPTEKSIRKRFAKAVSKGKVDMKITKATECPIGGLIETAVKEKFDATPCMQAQRLDKFHTQAREALNILYTYNRSYEPFLISWLFPLQLAFQEHQRKEEHPYELALYLDLLLTYAFPKWPEIFAVAEQAMARLKMADTELYDHLQECAITNVKVNPQDFLVHLIRAEKKKAAALSWSTSTDDPTNSSTGSMPKELLANPLIFLRKWVGEGFVGVLNSPAVMYIWDQCFIERWDRQVLEDACLALLLLLKEKFMKAIDYHQMRQVFLNEPSKILTLDMVRSYQHIREGQPPSAVPNFNRKNVLRPEKPETASPQATPEPAAVVTPSPVPTSMVQQTPEPVDTAPSTPKELEPQLERVQLCRAGLRNVRLKLMWNLTKSQLADFQMEKLLITVFLSIGDETLQVKQIKDSVIISSFAKENGSQDMETTSEQSSKENFGSKHQLSVPDIMFSAKEIELFKYDKELVPQVVLRIQYKTTTEEAADEGEQDANTSVGWALIPVYEKKTTPSTPNGNQDETADEVSTWSPDAGDRTVPLYFGDVPEDVTAEGAMKEFAEEDLLREGSKVGLTVFDPGNSPWVEHDPNLLVTADREVPVEEGFDLYVDGVRFLPDNATICKVTGRITLPSSQHRADMVTTALLDSPVRCPTFKYRYTMSVAEATQLAVLRMYTVDKVTRSVVVVGAAVLQLYVGESTKKLNAGGFQLRLHAGMPPMEELSIESMSQLPIIPACSLLVRLLPRSEEFIPAPDYASGYYSSDTCKPTTSEQRMMGHYMKSSAWADTVHMVLQRLRQVEAATEELNDEELTAWSLDRLDFKKQSDPDADKKPDRLDLLRCVDYDEEEGLYVSVMSAKAVRGEGKYSNISVHVLPGSDVTSEGELGPSDTEHFLVQDAKSSSLQTAPVFKDPPKKLHPSYSPRSLLLLRVIGLSITYKPDPANQGPGQMFGKDGTEPVSLESDSRLGWSLLPLFDKGCVTQGSYLLPIFQDDGKFSFLKELSDAPDLYGWMVSALQKGTIALDTSYASLTLTLWDGHFDKGETVQLLMEDRFLNVDDFQKFAAAADGVKGQPMSDLILQSLPPEVREEGVLSEMYWREEERFQEVMKTTFKDVIDKMKLTEDEEPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7Y0</accession>
    <name>A0A914A7Y0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059539.1">
        <property type="nucleotide sequence ID" value="XM_038203611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203611.1">
        <property type="protein sequence ID" value="XP_038059539.1"/>
        <property type="gene ID" value="LOC119730624"/>
    </dbReference>
    <dbReference type="GeneID" id="119730624"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="371" mass="42436" checksum="98D00730B1A6DE0F" modified="2023-02-22" version="1">MGSNSRGKDKKTASKRRVSSSDSSSSDSSSANSSSSESESEAPIQIKKQKVDSATKKQRRREKKREERRKKKKELNKISRDDFYHKSTEFRLWLVEEKGKYFDQLSGSKAKSYFKRFVKKWNSGKLSKKFYRGIDHEDARTSLTKYKWKFAELHTPPKKLDIAKYSDRHNTARGGEHMTPVADGLMKPKTFSTFGKSSSSGSQEDDCGTSIGPSRPVQGPARPVQGPTRPIQGPMLPGSTLSQAEHEDRQEQSAQQLRKERKDFRKHNQMVMEELVPKATGHEARIEKRLARADKRRQRGNSPETRESFLFGGKTDIQSQLDAHRQKKEQRRERLEDKAATKLEVYRAKEKAKMTALLEQARASKSANALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADD1</accession>
    <name>A0A914ADD1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xyloside xylosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061940.1">
        <property type="nucleotide sequence ID" value="XM_038206012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADD1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206012.1">
        <property type="protein sequence ID" value="XP_038061940.1"/>
        <property type="gene ID" value="LOC119732484"/>
    </dbReference>
    <dbReference type="GeneID" id="119732484"/>
    <dbReference type="OMA" id="LTNTHKM"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140560">
        <property type="term" value="F:xylosyl alpha-1,3-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042465">
        <property type="entry name" value="XXLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46612:SF1">
        <property type="entry name" value="XYLOSIDE XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="63911" checksum="5EFE69E9AD423BAC" modified="2023-02-22" version="1">MVRQRKHDGKNLKQSGRLQSAKQESRPQPLEEASTPPTTTAADGNNMQYVSNSRSKARLQQFGPQPGFLRWLLRLRLTRAFFMVMVVGVSGFLLGRMVHRGHRVFIADPQGGFQAHKNLRTQQNLNHPNTLNQGDAQHRHANAKNGAQLDAPIQQPFVHHEAKHEAKEGEIPMSPEEQRHFQEVYDKHAAMRKKAKEMRESLQKAGQQNAAQPQAIVPQQQPPHVGQQPDVQNQNGQQPAANLPSAVETAKANQPKIADAPSDFETYPYHVIQTLTNTHKMPHLKTRFIECTKSILDKASINLHFFFVVDEPSKKFIIEALQDITNQHIARNKFQFHFIEVDELARQLAPLVSMLQEKVTGGHPYYQDAIFFLSVAIHRGILPSYVRRIVMLDSDLKFMTDIKKLFDRFDLFTSNNIMGLAREMQPVYRHLLSLYRNMNQGTKVGDPPPDGLTGFNSGVVLLDLEKMRNSAAYRGFVNAEKIHQLTEKYHFKGHLGDQDFFTLISLDMPDLFHILPCSWNRQLCTWWRDKGYANVFDQYYRCDMEINVYHGNCNTPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADF7</accession>
    <name>A0A914ADF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061847.1">
        <property type="nucleotide sequence ID" value="XM_038205919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205919.1">
        <property type="protein sequence ID" value="XP_038061847.1"/>
        <property type="gene ID" value="LOC119732416"/>
    </dbReference>
    <dbReference type="GeneID" id="119732416"/>
    <dbReference type="OMA" id="MSRNCER"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="20611" checksum="163FB2310D0402E7" modified="2023-02-22" version="1">MAKKNNFGIVGDWHLPSFPDITALEDELCPGDRLEFDFGIYAHWGIYVGRYQDMRHAVIHFGMFEKRATFSKKKISGSAFAAGQKPEIRADTIGMILGGSGKVRINNSRDLKVEHLDPDVIIETATTMHRDKTPIDYNLIENNCEHFVNLCRYDKPHSQQAEDLVIGALGLFVGGAIAGEYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGR3</accession>
    <name>A0A914AGR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062711.1">
        <property type="nucleotide sequence ID" value="XM_038206783.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206783.1">
        <property type="protein sequence ID" value="XP_038062711.1"/>
        <property type="gene ID" value="LOC119733193"/>
    </dbReference>
    <dbReference type="GeneID" id="119733193"/>
    <dbReference type="OMA" id="WAMEERA"/>
    <dbReference type="OrthoDB" id="5983081at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1765"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1879"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2100"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2225"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2238"/>
            <end position="2248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2667" mass="292531" checksum="C0C1A93FB92FEAE4" modified="2023-02-22" version="1">YRSVTCYRCCTGWTGSTSSGCTTPICFGHTDSCPNGGDCTRPDYCSNCNRGFYSPRCNRCTAIANCLEVFCSTSSNQKCYRCDGDYGSARGSAYKKSDDMRQCIKQCSWRSNSNACFPGSCTNGQCRCSSGFLGTDCRTLGSSQAPVLSEHRATLVNGTTTRESPSVQGSTDTVYTNVRDFTSIRANWKSSYQPTGLPAYSGGGHPYIQSIRFGVVWARVTAAVNRGNRVIYSVGSQACTTSTTGNSFNRNNPATYLVSCQVTFNLNYNSWTPATGDVLRYDVYSTSGGYMKLYDRDHSNSIITRHYNGRTTSGYSTFTFDFDDPYHCVDVGSGCRTTMLYAGNDVTSQAEIIVTWQGWADSLAGIKEYELQVRQLSGSHGNQMTEVFDSPAVYSGVTDSSQNITLHHVGVYSIVLSVFDNTGNVGLSRRFVFFDDDPQDVTLQDDSSLRVVSATAETNYEWMTSLDSSGGMTSVQLDWTNRFMNAPHHNQGLLKPIGSYVAGTIDSDYDQSFGRRGRAAIPNTLGVTEFRVLHDIDHSGGRTTVIVSDDNSDHWSSEGTNTQATYDLTLVDGDSIRFWVEARDLAGHFVRDSVLVHADSSPPVIENFWLVRDGEVNLAVHNSKDLDKMSVEFRTYDIHSGIQTIEWRLFDNHTGTEMAHGSRNLAAMKINNTDTEKCDPVSCMCVPLGDCYVVDYGFHPTMHIGTHDYDYYITLTVTNQASLATTQTIKITVDASAPQAGVVHDGIPGSNEIDYQEGSDLSAHWEGFFDKESGVKFYQYLFDDSCRTGYTTVGSAMNDMTKTTATHASWTAPSPGQYYITVIAYNRALEPSAAVCSDGVVIDTSPPELTQIAISYARMWPGLAKDAEGRVWFINEHRRKMELMNASSDCSSMAALVDDLSVYPEIAGTNDSSAILQGDLDCVWISPIEQKFFLPIDKHLTISWTGGIDTESSIYDYEIGLSSDPSNPTPDLVTFMSTSGHDHFVMYHPHISQGAVFFLVLKAINKAQLSTFKVVGPIVVDTTPPMFVGRVSVHVEDDYLIAAWGDDGFIDDEDTSLRYQVAIGGSPGGTETLDFQKEKAYRIGPCLSQTSCAAFSLADLDWHLHGDRDYYVSVRAQNGAGFATVGTSSVYRHIVQLPSLGVVLDVAPPGEKVHVDLGVAKDIDVQMSTASISARWFGFEHPHLDINYEIAIGSEGGASDVSVGFIDVGNATFYQLDGLDLIPLMTYYVTIRANSEAGSVNVTSDGVKVIQEGQVLEEAGIKDGLGCDQDETSTPPGLSHHSSAAQQPCQDDITYQSSTSDISARWTIPEVLQPFVTGVFWAVEQEIEIYLDDENTMMEWIPVIDDQDLGMSFQHVGAGVGLHGGGHYRSKVQFCHVNVCFKPVVTDGFWVLSQPPEVGQVTVSDVEATPGRTEIRVVFQPFAHDYVRHDDPRELMDFYEWSIAEDGSDGALLSQWTRIQDLVVTGDVAHFTASHSGSLDLDVCLQLSVRGYNKAGLSSIASTEIVDCDNVKLIVPHTVIDADHEVSMEQNAMWPEPDKNYISSTSSLSAVWPTLRHRDYVWAAIEDTGSFGNLDDGLQYPCDHPRSITCGSTNKEFVNVPGLVLHHGKRYRICIHADEVTLEHELWNELLPAVSSCSDGVVIDTTPPTPGSVWIGWNQHQTYQSSSSELVLQWESFTDIEEHGLASHHSGVKYYEYAIGSMRGGSDVVEFTHVGITNSVIVHNLRLQNGHTYYATVRATDFVGLSSHAMSDSITIDMSPPVFSADHSLDIGGSFIRSTTSISASWKNVFSDKESGVAYYEWAVGSHPGHADVMPFTRENTEIGVSDPSRPLHLHEGHSYFISVKAINTADLITLKSYGAFTVDASPPLAGHVFDGNPADAPANHRDRDFQEDRRVIRAFWEGIHDPHSAIVGYSWRAGMCPGCSNVVTEQHVGLDTDVLAENLNLVPGLTYYVTVTACNAADLCTSVTSDGVTVDDSPPLQGRVNDGGPGGGDISFQSSRRQLRAHWWGFHDPHSGLSHYEWRAGTTPGAADILPCTRIELSEDALIFLSAADQMPAGTDIYITVRAFNRLGMWSRATSNGFRVDSSPPDVVDAPAVDVTQGMAVRNTQVLRDLIHFSWKFSDPESGIKDQYVSVSTHHNGDVNIPSIKIAGSELDYTFTNLTLHEGSRYIVTVVACNFAGLCTQANTESFLVDGSPPSVVTFAIGTESAANLQRHHIIWIDPTEPAETPDGTDYATDSISSTTESPPTTPSPPRYHSGWMTWLEDPRTSLGSLALAWLGFADVHSGISHYLVSAGRTYSGTELTPNGPVRVNHSNDGMSLDEGIAQTAIIPLEGSITDPSHLYLYISIWAVNGVGIPSSRHHSTFEASPTRPDEGSLVLLRRCLPTTCKGHCACAPIDRTCNPDQSCTDVTHSNPNTEIEVLDVLDLMNDDINNVIDIDDTATQSMAAAVWRVTEQKGLDIKWFEWSIGDDSSSDPVGIFDPVQDRLWYDIGQNNQTIITLDEDHKMEKGVTYHVFIRAWYNPTTYAVFRSDGITPDITPPKISTVRGAKIKDLARSYARKDTDYLMDPNVLFISWKRVFLDDAMSHYQVSLSTYPGGEDIRQFADHTFPASVSSTQFTNLNLKSGLRYYSNVRAFNKAGLHTLKSSDGFVVDTRRPDAGLVFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGX6</accession>
    <name>A0A914AGX6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062644.1">
        <property type="nucleotide sequence ID" value="XM_038206716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206716.1">
        <property type="protein sequence ID" value="XP_038062644.1"/>
        <property type="gene ID" value="LOC119733143"/>
    </dbReference>
    <dbReference type="GeneID" id="119733143"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="17546" checksum="1C18B4BB02882DA5" modified="2023-02-22" version="1">MKIGGRPDLFVPFMLTAMFMFFHGTLADLHLWIGAIYHAFALEWRELIIIATAMSSILKFFNQAAFVWGRGHRVTIAGTSLFGPSLHIATAFLLTIVTKVMTNLYERQPCVFLIIFGLIEAKMSNQFMTAYMYKSKVKLLDSTLLGPLILCVNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHF5</accession>
    <name>A0A914AHF5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063425.1">
        <property type="nucleotide sequence ID" value="XM_038207497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207497.1">
        <property type="protein sequence ID" value="XP_038063425.1"/>
        <property type="gene ID" value="LOC119734152"/>
    </dbReference>
    <dbReference type="GeneID" id="119734152"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111002" description="Insulin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="134" mass="14808" checksum="0F34EBFC8D803E63" modified="2023-02-22" version="1">MNLFMVLMLGACAAVALAGPHANAAPPANDGIEVLTGGKIEEDDFEGDDFDVKNKNQYYSRSGPRFRVCGTTTHSWSSFVCHPSGLIHHKRDNDEFLSAGEANTFLMSEGVGKRGMHEECCHEGCWWEEMLEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIH6</accession>
    <name>A0A914AIH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063458.1">
        <property type="nucleotide sequence ID" value="XM_038207530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207530.1">
        <property type="protein sequence ID" value="XP_038063458.1"/>
        <property type="gene ID" value="LOC119734180"/>
    </dbReference>
    <dbReference type="GeneID" id="119734180"/>
    <dbReference type="CTD" id="57147"/>
    <dbReference type="OMA" id="HLCKFED"/>
    <dbReference type="OrthoDB" id="9942861at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF15">
        <property type="entry name" value="PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="823" mass="92050" checksum="DDF1FBC0DE4A98B3" modified="2023-02-22" version="1">MGAESSVLQGCKLEEPLETSSQNEWQLHPAKRKDGSRVSVFVHKKSEQEDRRLENAAKQLKILRHPTILKFFASCDNVEGTYLITEQVRPLEIVLDSLTPEEICAGLYNIAEALSFLHDRGGASHNNVCVSSIYVSVQDGGWRLGGMEHLCKFEDATAQFLKQSQPLRNTEAIPPEEQEESVSSTAPQYGHARDAYAFGILAQNMLEYLTDLGSMTANFEQRINDEFLNEDPTLRPRLTSLLNDRLFKNDFLEITNFLVHLTVKSEAAKNAFFEGLARRLHRLPRELVANRLAPLLLSSFVMAEPMAVSMVLPHFMTPLRETNSKHQEFLSDQVNPLFPEDLYKKFVVPVILKIFPSREMHVRLCLLQYFAFYVDLFDVNVLKKGILPQLLIGLKDNHDELVSASLRGLADTVPILGAHLVVGGERIKYFVEGRPKFLSKNDSPLKNMDNVTNLTAVSGVITIPPLEKTPPARSSPAPVPDSGRASENEEEEGCQATTVARRQEERERRREEMRMKNEQRRKEREAKKTQQSGKVTLLSMANINKDSVESADDIHSEELSPRFEETNPSEEFEERLKDVAISQEDSDEVDPHKDKDDWSDWDDMDQSDQSAGPISPDSELNQSGSLLLKSRQTQEPVLAKPIETDSAETGDTVVNFDWPRVDDDRSKPDSDWTESNSGHASSKKPLKSLQLKKPPVAKVSPEPKTETNKPKTQPSGVKIAPKRPTKVTKIPKSSELGSEFAIPDIILSPKQRSQEPDFFADMEPSVSFTTDAKKGSKSGKASPRSESAQSTSKAFHANTVSTNPDDNGDGWGSDGDFDWDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ91</accession>
    <name>A0A914AJ91_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063474.1">
        <property type="nucleotide sequence ID" value="XM_038207546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207546.1">
        <property type="protein sequence ID" value="XP_038063474.1"/>
        <property type="gene ID" value="LOC119734193"/>
    </dbReference>
    <dbReference type="GeneID" id="119734193"/>
    <dbReference type="OrthoDB" id="10467504at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="797" mass="88924" checksum="1A374C2CE3856EC7" modified="2023-02-22" version="1">MLTPWYPATPVSSRASSPRPTHRSSFNIIPENADNINDTAPDEGRQQRANSRSFLGRLIHRKSRTGTSSSYGSTSTIDQAVDTEICIEVPQDRTPPKILENGAELDSSNTNQDKGLQDEADKSYQDNKDDGDDNVFLDVEPRPRLASAESSCSEYEAPADGDNQLPKKERSTTLVYKPPVEDKEVQTEHVDYMYADSRSMPCEYCRHRCLCYRIDPYDSNSSTQSLKLNAEEKSKRRRKRWSPLIRKRQLLMKQAIANQPPTRVGHYEHGYQSTPIRPRPSGMLAQITDTTSQSQPPSPKRWHMQYRQNRRRRRTFSEDRVDEMNSAAGPHCGNTNSDPSLCPQKSTFALADENRQSDPLRHARLYNLCLQKAKMPLVKSSSYSPTVPLRRQTWSEKSRPNGPSCEGPKKTKGFLYMLRNLRSSCSETDISMEHRPSVDSNGYVDPFYITRHFNRLNLKRLSLSHPNLNTGFKGSTTPPSSLKGKVTAAVGRLERALTGRASFGRTYSLESQQSTSNGWNSDLPGSPTDSDAAAYSYGKHYRRDSNTENGYMTFDPELNPPMRRPRPLLSSSCSSAPSSPGFQEGLSMGFDDVTSNTGNEEECIYESLDNYSPKRRASTLKSLPSSDGEAPPEVPPRPPAHRLRHRQRMLRRQMPLPPIPNAHSTTDLGERSQVPITTTSSAGNIHTAMHSLYKTTGSRHNFISGQSSSCSTLPSFRMDSSEEDSVFEAQVENASLSKTLKGRTIGDTGLGKLKGEEYTDANCNHDNLTDTCVSGKNCNSHRANDLEIGASSTINGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJW0</accession>
    <name>A0A914AJW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063836.1">
        <property type="nucleotide sequence ID" value="XM_038207908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207908.1">
        <property type="protein sequence ID" value="XP_038063836.1"/>
        <property type="gene ID" value="LOC119734411"/>
    </dbReference>
    <dbReference type="GeneID" id="119734411"/>
    <dbReference type="OrthoDB" id="1910009at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051084">
        <property type="term" value="P:'de novo' post-translational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF6">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="158" mass="17720" checksum="88812E2EBD6C5FE4" modified="2026-01-28" version="3">MADPLGLFALFLCLIQVARSSGQFESPSPPLRQDCFALGLSSNLLCSSCSVLPNHGLESLVPDCQTCCHKDNDAEDQKLYPKAILEVCSCKLGRFPQIQAFVKGERAQNFPNLEIKFKRGADPALKFLNEKNQVQETLSIERWNTDTVEEFLQERLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKB4</accession>
    <name>A0A914AKB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063849.1">
        <property type="nucleotide sequence ID" value="XM_038207921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207921.1">
        <property type="protein sequence ID" value="XP_038063849.1"/>
        <property type="gene ID" value="LOC119734421"/>
    </dbReference>
    <dbReference type="GeneID" id="119734421"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="623" mass="71525" checksum="7C1EAE3AA99AB67E" modified="2023-02-22" version="1">MDVKPGNCWRCMKPLPEGPVTCGRCPQAKYCSDQCQRQDRVRHGAVECQMFGPKSCSYCKKTGEMKPCAGCNNAWYCNGTCQRKGRAAHKEVCQDIQAIITDLSNKMTKDYADLSRQDGYSKRDIYLDPPYYFGTTMAYDFLQLKQNEWADGISEETMRDFYIFSAGCGDLRHTVLTAASLPAEYQGKVHIVLNDSDPYVMARNVLFLYTLIQHEDREGIATSLATLWYSLHISKSDYDLTKTSLKKLIQADARGISETTKGCVSITDEDVAKLRYVWKGWYSLECQRIRSSSVNLTKRRQFVLTQVPSFQHELKIYFERLSPKEAESLKTWFQHGLFLAQDTPIGSLPFDNPTLTARIRQNIDGHLLVTENFVYCIHNSNTPFKAWDSLQVQECSAGETTSATVMYHKYVAQQLQKTSTLLSQGRLHIHMLVSCCFEIPHDHQALKMAKFDRIFTANLADFFEFRKLLQTLGPLLNPNNKNATLVTEITSWIIWMPEASGWDRRTGRDINNSIKTTMQLCKDDTGKELSCPEAIRYRIEYFNNTHWFCAYLRANMMAGGFHIPELDHIPSLKEAMKCEGLQMRDFREELNKLVPFKKRVNARSLTSPSGQERALEWYLPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKQ6</accession>
    <name>A0A914AKQ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064151.1">
        <property type="nucleotide sequence ID" value="XM_038208223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208223.1">
        <property type="protein sequence ID" value="XP_038064151.1"/>
        <property type="gene ID" value="LOC119734690"/>
    </dbReference>
    <dbReference type="GeneID" id="119734690"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="265" mass="29332" checksum="B73CE3C10F1C4B13" modified="2023-02-22" version="1">MATSNKLCYTSEQILPVAPLLTAKQLLELPGRRSLTMSKKLMALWKSKAVPNVSAKSIVSYQTVRRDKETSSATESLSSQVQGSNQEIMPGSPERPRDVSVDSATGSRMEETPPIFSDLSQLSESRDSTQPSFQIEHTTGRQKRHLTGQSIEEETTTPLDKTGMEIPVPTLQLEGIPEKHKSPENSSSEEDQPIKIHHQKVVRDIAELTAVDETITFKDLVPLSTSCARASKVFSICVEFAASNLIVIWQTIAYGDIYIKRGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKV7</accession>
    <name>A0A914AKV7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038064064.1">
        <property type="nucleotide sequence ID" value="XM_038208136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208136.1">
        <property type="protein sequence ID" value="XP_038064064.1"/>
        <property type="gene ID" value="LOC119734602"/>
    </dbReference>
    <dbReference type="GeneID" id="119734602"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="257"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="399" mass="44763" checksum="0091384428D53CD0" modified="2023-02-22" version="1">MAAPMTKMPSALSLEILAECSTTKARTCKLELPHQTVDTPVFMPVGTQGTMKGLTTSQLEQLNCQLILGNTYHLGMRPGPELLEKAGGLHKFMNWKRALLTDSGGFQMVSLLELAEITEEGVKFQSPYTKEEMLLTPEKSVEIQANIGADIIMQLDDVVHSLTTGPRVEEAMYRSIRWLDRCIAAQKRPREQNLFAIIQGGLDTRLRTICAKEMVKRDTPGYAIGGLSGGEEKDYFWKMVTLSTDILPREKPRYCMGVGYAVDLVVCCALGVDMYDCVFPTRTARFGSALVKTGQLHLNQKQYAKDFRPIDENCDCSTCKQHTRAYLNTIAGRESVACQLISVHNLKFQMDLMRDIRQAIIDDRYPAFIKDYMKTVYPAGDYPTWLRDSLASVNVDLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALZ4</accession>
    <name>A0A914ALZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064546.1">
        <property type="nucleotide sequence ID" value="XM_038208618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208618.1">
        <property type="protein sequence ID" value="XP_038064546.1"/>
        <property type="gene ID" value="LOC119734960"/>
    </dbReference>
    <dbReference type="GeneID" id="119734960"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037320056" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="236"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="329"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="575" mass="63685" checksum="3B026722C4D3C78F" modified="2023-02-22" version="1">MAPSSYTALHTLVAFIFVLTSVQLAKSLTLDVEDEDRFPVPNSEVRLTCSGHHDGILTFSGNPQTEGRVVWTKDRQRVAEWPKPAGTETPSKYELSADTPDYTMFFADLVIRSMDITDNGVYKCRLERGETVLGTSNGERLTVEQRPANQYPVCSIRTLENKRTFICESERGSPPVTLQWWKDGQPLGPSSEPDDDLEDFVQARLLMADDESSRGRFECALTFRGELTRSCILDRPNVTIPTTTRGLSIGQELVVVCITSGNPPVSTVDWNFTPNLHSSVRKEGHVLSIFNISSRDNGTEITCEGHNAVGSNQASTVITLRPPEPIVQPMTVRLEQSEIPTSVDEQAQFKCITTPLRSPPPPSVWHYNGHYVDPLNTTDRFLMEDRTEHVLSVSGVSTLDVGASVTCRIMVSYQPNAEVFLEVSFPQTTKAMTVEPTTKITYLKLGPPSSDTWSLSTLMGFIIGGLMCLVLVGVCCWVSLKAKTLTCATQDSNNVRENGTGTRASCNHLNDDFVVDLGIPPELTARLNMATKVVDEEESPYQDLEDVSRQRQSDEYQRLVSNDLAHALTPESSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN92</accession>
    <name>A0A914AN92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065073.1">
        <property type="nucleotide sequence ID" value="XM_038209145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209145.1">
        <property type="protein sequence ID" value="XP_038065073.1"/>
        <property type="gene ID" value="LOC119735447"/>
    </dbReference>
    <dbReference type="GeneID" id="119735447"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="19493" checksum="6392314F03A77E01" modified="2023-02-22" version="1">MGNVPRFVKAADNSSEGDTKGQCAADASTGSPIYAVPNDLIPTILQHLSAADLCHVASCCRWLRILANQDSLWRHLCQSRGWEHYGTTTDLAKIASYGPSKQATGATRSGHYSVTFQEDRIVTDDNTAGLTSTCRWKGVYMRAYHLDRNWSTNHSHECKIKFKLYSSPNFFCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APU9</accession>
    <name>A0A914APU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038065464.1">
        <property type="nucleotide sequence ID" value="XM_038209536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209536.1">
        <property type="protein sequence ID" value="XP_038065464.1"/>
        <property type="gene ID" value="LOC119735684"/>
    </dbReference>
    <dbReference type="GeneID" id="119735684"/>
    <dbReference type="OMA" id="TEFVKGW"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000301">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase Chk1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF107">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="474" mass="53991" checksum="5D0F9C48C8AEF09E" modified="2023-02-22" version="1">MLAAGFMYFVNHNMNHVDDELIFLVKLAVNRSTQEAVAVKILSLDKAKGAIENVRKEVCVHRMMNDDRIVRFYGQRKEGNIQYLFLEYMSGGELFDRIEPDIGMPGKQAHRYFVQLMAGVEYLHKKGVTHRDLKPENLLLDDNDNLKISDFGLATVFRHQGKERLMAKCCGTPPYVAPEVMKKEEFPAEPADVWSCGIILVAMLGGELPWDEPTYECKEFRDWLDKKMHLSPWKKIDPLPLALLRKILTESPTKRCTIATLRKDRWYNGKTWPHRPPSSSPTSSGSFKRVCSGNDLSPTSSIRRENSAMFSSSQPIPHAVHDMPTPETTKESVEKLILGVSFSQPVHIDSLLLSSQIQSTPGSSQTPMQRLVKRMTRVFTKLSPDETIKKLTAVLEKMGYSWKTTTARQVTITSLDRRKNPLIFKAHLHEMDDKVLVDFRLSKGDGIEFKRHFLKIKGKLAHITTKVPLLSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQZ9</accession>
    <name>A0A914AQZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Brain protein I3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066083.1">
        <property type="nucleotide sequence ID" value="XM_038210155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210155.1">
        <property type="protein sequence ID" value="XP_038066083.1"/>
        <property type="gene ID" value="LOC119736143"/>
    </dbReference>
    <dbReference type="GeneID" id="119736143"/>
    <dbReference type="OMA" id="KVTQPQY"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40089" checksum="5FAA3AB81C7F2A1B" modified="2023-02-22" version="1">MQRPAAVYIARSAGRAESMDGLGTDDERSPLTAPEPYSDDPAQGEGTTTGDNQPEEDQEPAGQPLPGPPSEGLTAQQDGLSELDPGAKQETSGVTLGEPSPGPQINTPGVVPQQPPTVHPQEQGPGSHGSLDRPPVFQSTPQGAQMPGGNAPPPGTQAVRPGQGPEGVPPDPSSQWRPGQAAPVMNQPQPVLPAANSQQQQQQQPYQQMQQQQQHYPPQQQHQAQLHQPQQHYQPQAQPATDPAYQQQQEPGQRHQHASQQQQYQQQQEQYREQQHYPQQQQQQHQQQHPGQQELHFPAETPQRTVKVTQPQYQPLVSNCPQCHSGVLSQQFSLLGILLAIFCFPCGVIFCLLMRERRCSNCGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU37</accession>
    <name>A0A914AU37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067272.1">
        <property type="nucleotide sequence ID" value="XM_038211344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211344.1">
        <property type="protein sequence ID" value="XP_038067272.1"/>
        <property type="gene ID" value="LOC119737172"/>
    </dbReference>
    <dbReference type="GeneID" id="119737172"/>
    <dbReference type="OMA" id="ECAAKWA"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF31">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="309" mass="36016" checksum="F2B79C862391581B" modified="2023-02-22" version="1">MDMMHQHQQLMVAPAKRGRKPKEGKQKRKRRPKPTDHIKKPKTGYFYYLEAFRKNFGKNGEQIPRASEITKACGAKWTSMNEAEKKPYADLALTDRERYLAQREMFTKKRDPDKPKKPATAYFLFLEDFRKKMKGVPLEPGKRLTVICGEEWNKLTDQQKKPYQDQVAIKYQLYEEAMKEWRLKKGIPEPHKAPTQPSQSSMSHMQAASMQQQAQHQQVQQQAAAVQQHRQQQQQQYGQVGLGMANSYNGSAQAAAAHQQLQLQRMHMQQQQQQQQHHHPTAAPTHPDDDDDDEYDDEDDDDLEYGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUP8</accession>
    <name>A0A914AUP8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067805.1">
        <property type="nucleotide sequence ID" value="XM_038211877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211877.1">
        <property type="protein sequence ID" value="XP_038067805.1"/>
        <property type="gene ID" value="LOC119737481"/>
    </dbReference>
    <dbReference type="GeneID" id="119737481"/>
    <dbReference type="OrthoDB" id="10093692at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972616" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="158" mass="17447" checksum="10D77C59A6157B78" modified="2023-02-22" version="1">MNAHSVTALAVIIMTIGIDADLKHCFCDLRWSTTQLESGDSVISVPVLRDLTNPYYRHFIHVLEHCPHDCLANAHAWMGGATMTNLSGPDACISAATNAPPGSPIYVYASYDPSVCGDRSWQYIGPLCCWEISFPGYESFFLYNHECNDSCPPNNPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV92</accession>
    <name>A0A914AV92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068015.1">
        <property type="nucleotide sequence ID" value="XM_038212087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212087.1">
        <property type="protein sequence ID" value="XP_038068015.1"/>
        <property type="gene ID" value="LOC119737623"/>
    </dbReference>
    <dbReference type="GeneID" id="119737623"/>
    <dbReference type="CTD" id="81533"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="479"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="634" mass="70894" checksum="BAC48E00044A922E" modified="2023-02-22" version="1">MINVENDVKLKMSPFQCCVFLFFTLFSIAFSDDLFAENTADFSDTTNQVFGGVPGDGIVAAYGDFDSDKRTDVFVIRENGHVMDIYFQQMKEIVTLSKTVHSISITRNNDTITSVVPGDFDGNSQMDVLITTKPNGRVFDPLAPTSAFVYWGQNAKYKLGPVTTVTKVLKDQPLMMDYNADMVPDLFGVDMDGVRQFWTFNDTDNHDFVSIPLDGPSAPLQIPNSNAFLDLTGNYAADLFVTSLDENDITKSQFEIWQLLAGEPDAWKMQQPYSPPELQGKAVQLGQSSFADMNADGKIDHVLPVCLDSECRKSLIYMRDGASDEWILLLDMSATTKEKWGFVPPKEMSKWAYMPITARLGDTNMDSYPDILCILRSGSNETRRVVLLENKDGKSLEPVWDSKALNEIEKPILATFMDLTHTGILDILVVNQSQSDVEPQIHVIKNNFAVDAYFFKTHILSGLCFSDCDGISTKYFFQPYGVNQPGPFIHYTTTSSTGVLQHGAAPQLYQSAYFSLQLPYVVLGLGQNPNYVDYLTVSAPSPTRPREENARQHTFTSIIPNSEVIVIPFPLDTPEEWKSVLIITPGRSVLVTGGVLVGTCVFMALVVGILQLLEKREDDREKRQESHRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVJ3</accession>
    <name>A0A914AVJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067780.1">
        <property type="nucleotide sequence ID" value="XM_038211852.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067781.1">
        <property type="nucleotide sequence ID" value="XM_038211853.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067782.1">
        <property type="nucleotide sequence ID" value="XM_038211854.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067783.1">
        <property type="nucleotide sequence ID" value="XM_038211855.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067784.1">
        <property type="nucleotide sequence ID" value="XM_038211856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211852.1">
        <property type="protein sequence ID" value="XP_038067780.1"/>
        <property type="gene ID" value="LOC119737467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211853.1">
        <property type="protein sequence ID" value="XP_038067781.1"/>
        <property type="gene ID" value="LOC119737467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211854.1">
        <property type="protein sequence ID" value="XP_038067782.1"/>
        <property type="gene ID" value="LOC119737467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211855.1">
        <property type="protein sequence ID" value="XP_038067783.1"/>
        <property type="gene ID" value="LOC119737467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211856.1">
        <property type="protein sequence ID" value="XP_038067784.1"/>
        <property type="gene ID" value="LOC119737467"/>
    </dbReference>
    <dbReference type="GeneID" id="119737467"/>
    <dbReference type="OMA" id="HFNRCQH"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="5">
        <location>
            <begin position="221"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="739" mass="81876" checksum="5F741D6488374940" modified="2023-02-22" version="1">MAVSFLSRAARLYSRRCCAIKGSHPYQYSISKDGLKKRFSSDRFGERNNIILIGSPGCGKTTVGRILGQRLGRPVVDFDNDYLESYWGMTVAEKLSAVGQESFLAAESEALLNLDLKDSVLSLSGSSPMNRPAMQHAAQSGVVVFLDVDSRDIAQRLNRMKVDRIVGQRPGVSTLDLLAYRQQFYEGAYDVRILCERFQNADDIGEKVLTALCDHQKRPGYVSTRSDSEIQESAQPYKAPDFLDVVLQGLADDAGLYVPNKEPPHLTREEWTRLLGCTYQQRALRILEKWIHPRDFHPSSLATAVERAYSVENFQSESVVPVAHLQDNQYIMEVFHGPTASFKDAALQLMPQFFTQAVQMKGEKVRYMILVATSGDTGSAVLDGFSKFAGESGTLVMVLYPENGISEVQKLLMTAAAGDNVHVVGVDSDFDFCQTAIKGIFNDSALNAELLSNHGLRLSAANSINWGRLVPQVVYHASAYLDLVKQGVISMGDECDICIPTGNFGNILGAIYAKTMGIPFRKFICASNENNVLTEFIQTGCYDLRHRHLHVTMAPAIDILKSSNLERFLFLVTDGDGAEIRRCYEQLATEKYFQVSPKVLHRIQNEFCLAGDYCKEEEYAASIKKTLTQTGYLMDPHTAVAKVVADRLRPRDRPLLLCSTAHYSKFPTDVAKSLGSLSSPSDHPAESLRGLEALASRPVSHRLLREALERPRVHCGIVGASRDDVVNEMVAFAARATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVR4</accession>
    <name>A0A914AVR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068190.1">
        <property type="nucleotide sequence ID" value="XM_038212262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212262.1">
        <property type="protein sequence ID" value="XP_038068190.1"/>
        <property type="gene ID" value="LOC119737713"/>
    </dbReference>
    <dbReference type="GeneID" id="119737713"/>
    <dbReference type="OrthoDB" id="5971311at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF14">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="490" mass="54802" checksum="26801C630BAECE82" modified="2023-02-22" version="1">MTDVLADYEEAKKKVKMYESTWWNIALRGEQLGKTLDEEMVDRRSVQNLLDNLKMLGQQRTFCCGGWIELSHPDAHTRLKVKEDATNPRGWRITGLPVDGLLEFCAPSPYGDLKKGETVYNPSVRLASECEAAKFQFGRKSHQKSKPGDKRKTEASPQGLVDYTPQFLSVIREKVSKSLANGKDVVLQCYKLNVYGKGGFFNAHVDTPVDAAQMIGTVVVCLPCKHTGGALTVEHKGTKEEFLFANLSDDQSKIQWAAFYSDCVHEILPVEEGSRITITYNIIKQDRASFVRGSGLCQSESFSSGPMLEADNEPTLNGIASAVRMVVSDGEVFDSAFFGYFGIFLQHKYTMAALAAGNLKGCDQVLHDGLAARGLTCRPLTVLVHEVERYDTDDFFDGEPGERDVFAFSQEVVDYMNNKGPKPERVYPSWVMFVKEWSKERLLISENTREGEYCGNWTEGDEVETLYLQSALVIGFPKKSKRPGVPKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW31</accession>
    <name>A0A914AW31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067962.1">
        <property type="nucleotide sequence ID" value="XM_038212034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212034.1">
        <property type="protein sequence ID" value="XP_038067962.1"/>
        <property type="gene ID" value="LOC119737580"/>
    </dbReference>
    <dbReference type="GeneID" id="119737580"/>
    <dbReference type="CTD" id="81620"/>
    <dbReference type="OMA" id="LTAMMTR"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071163">
        <property type="term" value="P:DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08767">
        <property type="entry name" value="Cdt1_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08674">
        <property type="entry name" value="Cdt1_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1420:FF:000005">
        <property type="entry name" value="DNA replication factor Cdt1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045173">
        <property type="entry name" value="Cdt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637:SF1">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="4">
        <location>
            <begin position="450"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="834" mass="92281" checksum="427F0C95BDDD61B9" modified="2023-02-22" version="1">MAQVKVTSYYTRRKRIDDAQPTKRRKLQPSASGQETDLGPEQSGLKLKAGLDAFTKQLLPQVDRAVLLEDTISQCSKTSASTTRPKSAKKSRASATRTAKKATKGPLDKHLEKVTQSESPKLKLGLSLELKTDFGDSVKIPEFVTHRSPPSTPTKRPKQTDEAPSRKKRSRIGSEDVVVETDGSSCQMTKEAESSRASRRKVQAAGRQASKRTNGGRSAKKSLEASLGEFANSNELDTRDRILPKVETPHHCVNDDSHGITTDRQESSQPSTPVNPEKSTAASSSRSSSVSQKMPDSSQSSRDSGKLQAFMERTSRSVASVNSKGSKVKAGFSDRVQEAVSNAQSSPSEKVVDSGSASEEKKKTKLTPAEMKERLSKSCKLSDLQARLARVRQCADQAKSSQKPATAVNSDIATSTREPTASKIKSEEPAMPAYQKYHALVNSAPTTLNLPFKYKLLEEMFRSTDTVVSMLHNRSETCSFPKLKQAVQEMCRRTFEQQHLGQIKTVYPTAYFLRQQKVGRSGVKEKTNYELVLEANTGSGVGTSAGQESSEPTKTKSQTNAVSKLISKFTPSMLIARRSIFHNNLVDIIKEHHNEFLSKLERPLSVPSDKLTRWHPKFPLDQIPDVEPAALPQPPTVTTYNTAKDVLDKARVMMNPRVAKALEVVAKNSALLKAEKGKPTAEQETSIVKQEPKVVKNVKSVSGVNQSLLDRIRAKEAQNVTAMMTRSPADQERITMLERLPELCRILRVFFIAEKKAAIPIEAVIQKLADSYPSILSKAQVEKHVSLMVEVLPQWLSRVVVRKDHYLKMNRTKDMSLINDRINQLLKESKQVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY13</accession>
    <name>A0A914AY13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038068578.1">
        <property type="nucleotide sequence ID" value="XM_038212650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212650.1">
        <property type="protein sequence ID" value="XP_038068578.1"/>
        <property type="gene ID" value="LOC119737970"/>
    </dbReference>
    <dbReference type="GeneID" id="119737970"/>
    <dbReference type="OMA" id="ARCASEC"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="125"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="420"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="596"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="705"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="882"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="977"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112243" checksum="5CA5E03B831D267E" modified="2023-02-22" version="1">MAGSQTVDVNVITNAPMIPQRSCTVPITITAFEITCVTNDPVVDTPGSDVSVPISLPTIPAGVTDVTFNFRDPENNSLKPLTSSTQYQATIPMSGSTTVNIPVFAYRPSSQQLACTIPITLRGLPYLSQKPSVTVSSTSATISWQAWGSNAMDRGDGPVIAYKVYYSLASSVSWTVAETVSVTNSSQALYSSTVQPLNRNTEYMFSVAAVLQEQGGEGPMSPVTINVTSNEPEPTTLSPTTTASTIAESGSPVEPSRSTRASSTVAPNPTPASDSIVTIVVVAVLAILVIVVLILVVLLVRHYRRRRSREVSVDGLKGKFGSSDHLSSLEAIDNPVSIPLEDVNSNGDVSPEPTATTTTPTTIDKARPKSGTSLISMLDSSSAFAGLPLYPPPERELKKDPIPLKEFVAYMRRAMQGPQLGEEWSSFPGIEAICSCDVSQLPDNKLKNRYRNIPAYDHCRVILDHDEDDENLGYINACYIKGYKNDKAYIATQGPNQATSHDFWKMAWQENVRIIVNGTNLVEDGKNKCAKYWPDVGKAETLGGILISAVSEETRGEYTVRKMTISKVGDKESSPRKITQFHYTNWPDKDVPKDVTPVLKFVKEFSEATPKDAGPYLIHCSAGVGRTGVIIGIHASLQRARAEKTLDVYNFVADMRDHRVSIVQTPVQYTFIHLALLEALFSDDTAVPAALLGKRVTELKKKKKLAEEFEQLNTITPIPSREKCRKSMAHTNQSKNRFPHTLTLEGCRPFLMTPREDGMEYNYINASSVDGFKQSDFAVVTQAPLPNTVLDLWRLVYDYQISSIIMLNAPDPDDTSCPQYWPDKGSDEYGPFTVTTTNTADLEGYRIKQMKLEHRRQKRSHYFKHYQVTDWPLGQEVPKSPSALLRLIQTVDKHKPKDKRSASLVHCIDGLNRSGVFCVLKNSLDRLHEEDVVDILQTTKVLRLNRPNLLNSLDMYRFCYEAMLAYVNNPEEFKAEAIPEPVYENTPRDMEKDKPKESIYQNLEPKSSETPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYH1</accession>
    <name>A0A914AYH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068747.1">
        <property type="nucleotide sequence ID" value="XM_038212819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212819.1">
        <property type="protein sequence ID" value="XP_038068747.1"/>
        <property type="gene ID" value="LOC119738084"/>
    </dbReference>
    <dbReference type="GeneID" id="119738084"/>
    <dbReference type="OMA" id="CLRNEYI"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="76" mass="9148" checksum="2953B2D73FCCA802" modified="2023-02-22" version="1">MHPDLSSHLHTEECNILIRKLLQCHKDNPFKKFTGVCNQEDTDLRSCLNREYHQRLEANKMKTNERRRRMGLVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYZ8</accession>
    <name>A0A914AYZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MGAT4 conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068892.1">
        <property type="nucleotide sequence ID" value="XM_038212964.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068893.1">
        <property type="nucleotide sequence ID" value="XM_038212965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212964.1">
        <property type="protein sequence ID" value="XP_038068892.1"/>
        <property type="gene ID" value="LOC119738202"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212965.1">
        <property type="protein sequence ID" value="XP_038068893.1"/>
        <property type="gene ID" value="LOC119738202"/>
    </dbReference>
    <dbReference type="GeneID" id="119738202"/>
    <dbReference type="OMA" id="IRETCTH"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="39497" checksum="03ECE98A9EA22C13" modified="2023-02-22" version="1">MGIKAWLCLQKRWLWLTVACVIVVVIAARNGLELGDTRGIVAQGYSNLPWMPEVLVRYTTEQTRTALDGTWSIDTGIDPTKVPGLTSDMGCMNLPNLDRDKALVLGHRRKERGFLTIGITTVERINASYLYQTLNSLIVNTNATERSQMSIVVFACDFKESARQEARDIVFRFPKHLESGFLQLIEAPRSFYPPLKNLKRTFDNPDERVYWRSKENIDNVFLFAYSVSMSDYYLQLDDDFTTVPGYVSTIRRFIALNRAEHWILLDISDKGTGKLFRDWDLLHVARYLVQFYQEQPVDFLFSALMQLHLQRRHFVVKPHIFKHLGNVSSLELKNKGRHVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B063</accession>
    <name>A0A914B063_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069357.1">
        <property type="nucleotide sequence ID" value="XM_038213429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B063"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213429.1">
        <property type="protein sequence ID" value="XP_038069357.1"/>
        <property type="gene ID" value="LOC119738526"/>
    </dbReference>
    <dbReference type="GeneID" id="119738526"/>
    <dbReference type="OMA" id="FRFEAIN"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="295" mass="31406" checksum="AF1111630B1EBC1E" modified="2023-02-22" version="1">MPANVMDSTVIPRQCPAVRSGKPAGHLIADILGYSQASEPSTVRGDSSPAETSVRGPAGNRRRRPRTIFTAEQRHQLETVFAVNQYPDITNREVLADAIGMTEARVQVWFQNRRARGRRHGRQTGGETPELQSPPTTPSPPSLTPQPQTAAPVKTEPLSPSVVVKPVQQPPSSSPNITPAAPVDFPSVIYCSPPQMYPASYSEYVLPTYGLYPPQPLGLCTGSRSPPPGYTVATLPGRYAGVYSSGYQGALVGTLATPAIFDASMVPQSTPISSHVDSTGPWGYGQGGLLAIARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0R3</accession>
    <name>A0A914B0R3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069364.1">
        <property type="nucleotide sequence ID" value="XM_038213436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0R3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213436.1">
        <property type="protein sequence ID" value="XP_038069364.1"/>
        <property type="gene ID" value="LOC119738532"/>
    </dbReference>
    <dbReference type="GeneID" id="119738532"/>
    <dbReference type="OMA" id="DATGCER"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100068" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="160"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="42277" checksum="91BF277010A745F3" modified="2023-02-22" version="1">MEPPLLKMVLFVAVIIASVITMGRGTLNECEGTECVPVLEYQLQKSAGVQHTNLHQELGTVRELGVKTDREPIVYDPKVTINEPSDPTTPSCNLSEVQGFINSELERTAEMYSRDEEEIRLQVFQLQEAFADFAANIRRRRAPLPLISEPTTAHQPISEPTAAPLPMDCTEAATRGVAESGVYMVQPRDGGAAIEVYCDMDTDGGGWTVFQRRQDGSVDFYRDFEGYRQGFGDLEGEFWLGNDNLHRLTAQDDYVLRVDLTDFEGNSTYASYASFNIADPSDFYRLTIEGYSGTAGDSLANHNDKQFTTYDVDNDDWTRNCAEQFVGAWWYAGCYKSHLNGRYVGEPYQGVAWFTWKSNYDSLKASEMKFRKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1C1</accession>
    <name>A0A914B1C1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069708.1">
        <property type="nucleotide sequence ID" value="XM_038213780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1C1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213780.1">
        <property type="protein sequence ID" value="XP_038069708.1"/>
        <property type="gene ID" value="LOC119738813"/>
    </dbReference>
    <dbReference type="GeneID" id="119738813"/>
    <dbReference type="CTD" id="56897"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="652" mass="70796" checksum="B17B29DCC65EB1E7" modified="2023-02-22" version="1">MMSAQLAHCPICNREFPMQSINKHIDSCLLEEHGTENDLKSDSEAETFLSPSRKRARLSSEDREKGEQGENRDSKKSEEVENDKESKKRKKINQWGSLLRPGGKSSKADTDGLTPNKKKTKVATEIPRHDDSRRLPSDATTPSLSSRSHSSPPLMNPSTQGSKPSPLGPFAKKSVSTKTEFRPLAERVRPLSFAEFVGQETAVGHQSLLRQLLESDVVPSLIFWGPPGCGKTTLANIIAQRAKASGKTRFVSMSATLATVATVKEAVAAAANEQRMTKRKTILFIDEIHRFNKLQQDTFLPHVEKGTITLIGATTENPSFKVNSALLSRCRVIVLNKLNTDELVLILRRAAADLGVAVLEEGAGSEMNGVGCSSDGDQPEDGISDGRPSIYMEKTALTYIANLCDGDARSALNTLQMVVESQLTVAQHSTSQSQGTSHQGTNGTSCPPVNGPGVAKGAETKRVITTSHVKDVLQRTHVMYDREGEEHYNCISALHKSMRGSDANAALYWLARMLIGGEDPLYIARRLVAFASEDVGLADPLALSQAVSTHQACHFLGVPACEVILAQCVIYLSKAPKSSMVECALMSVKKHIQEYEGSLPGVPLHLRPGSTKLVRDLGYGKGYVHSAAAGDQGFLPECIKHVDFFDNADLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1J6</accession>
    <name>A0A914B1J6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069366.1">
        <property type="nucleotide sequence ID" value="XM_038213438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213438.1">
        <property type="protein sequence ID" value="XP_038069366.1"/>
        <property type="gene ID" value="LOC119738534"/>
    </dbReference>
    <dbReference type="GeneID" id="119738534"/>
    <dbReference type="OMA" id="CEYIESS"/>
    <dbReference type="OrthoDB" id="10011386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="132"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="701" mass="78615" checksum="17AFDD126F796DA1" modified="2023-02-22" version="1">MSKKKKLDVIDFLTDLRHKDSIISTYLTARNPLLSNVANFAKAKTLSVSDKLSLLVAKFSFEEVQRVKDCVVESRVEDPVLLSEGLSADLDLCSALLNILHPIPAQQDSSSCSTSSSSSTNVSNSNIISTLFAPPVSYCIHCDKHLTRHHPITRVKYFTLRGLQWAKKVTLRCRSCKTVYNWNEYGSDATYWQLYEGKRRPSIEANDSVFFSRELFDFQCCLANHSWVSFSGFTESFNDAFDLSKKSGTGLTAKQVSSAFLIGEVENELRDLCQLDMFKLKKRDADIDKVLEAIENQRLLNTYEHPNCHKNCHAKGCGRVFVADGIWKLSFPHCMFKLQNEVCGIPVPSLPNVCTKSPAYGKAFCPEHCALAEKESIPTVLRAFLQYCVEKKVDAVTAVAATSQVPAAPSFIQEGPVSAPSDDVIGVPCAATEVGTPAPDLVVNEDAPDAPVDNETLGRVEDVLVNLPSSTSSVGSVIEAQGVSTFLRQHSSNISSIMAACIEEKPSSCKKDTGCKKRLQKWARGHLFIVRAGGHIEFWRSLYKSESPSQVFLILLSWLDVHLKSIPATEWSNLAVVYDNMCHLDNMIVARSPLPLPAPWSHMWYDLKKCVDRLHIRNHTDAHCKVKYHPKDHLEDTDNTMICEQTFVWLSRYKKIVCAMPKHRHLFYIHRMVKRRNKYTAKCYEQGDDPILPVVKSVNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1N8</accession>
    <name>A0A914B1N8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069411.1">
        <property type="nucleotide sequence ID" value="XM_038213483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1N8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213483.1">
        <property type="protein sequence ID" value="XP_038069411.1"/>
        <property type="gene ID" value="LOC119738577"/>
    </dbReference>
    <dbReference type="GeneID" id="119738577"/>
    <dbReference type="OMA" id="CENTECL"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037160688" description="Sema domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="49225" checksum="0EB5FAE24DAA2E8C" modified="2023-02-22" version="1">MESCRRHFTLLWAIALSWSIICVNMFTTSAEQLGDLSDYELASFDNPDILDEPQRRASKFNHFTLSDHGDVYVGAVNWLYRLNSSLEEIQNVSTCDDSRPDSGMSCYRTNNYNKILAVDSTRPNSLITCGGVYDGICQLRQLWDINNVIMESVLNVAAGFEDASTVWMLTQGRGGEAMLFVAVTNSRENVRPITRRNLDTNSFLSAREDDDSIFFSVSPISVVHPKYVAAFDLSGFTYFLVSQKEDLNSFVSKISRVCQGGPNLAAYTEITLQCSGSDGSVYSLVQAAHFGPAGPDLATSLGLHADEQVLYAVFAKNQGAPGTSDVPIDHSALCMYRMTDILAAFREAVRGCIQDGNIGNGPNKIDYLEGSFCNGYGISILDRYFCTPVTNDQNQTPLFKYAKGIAPVPSTAILELPGTLTSSVITTIEVNHTIALIGTSSGDLLKVNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3V9</accession>
    <name>A0A914B3V9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peripheral plasma membrane protein CASK</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070608.1">
        <property type="nucleotide sequence ID" value="XM_038214680.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214680.1">
        <property type="protein sequence ID" value="XP_038070608.1"/>
        <property type="gene ID" value="LOC119739668"/>
    </dbReference>
    <dbReference type="GeneID" id="119739668"/>
    <dbReference type="OMA" id="STKWASF"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14094">
        <property type="entry name" value="STKc_CASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000062">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="22">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="22">
        <location>
            <begin position="401"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="21">
        <location>
            <begin position="492"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="579"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="20">
        <location>
            <begin position="707"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="895" mass="102292" checksum="1336778C7E3C2B63" modified="2023-02-22" version="1">MTDEDLLFDDVYELCEIIGKGPFSEVRRCIHRETNQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGLLYMVFEYMEGADLCFEIVKRANSGFIYSEAVASHYLRQILEALRYCHDNDIIHRDIKPHCVLLATKENSXPVKLGGFGIAIQLPESHLIAGGRIGTPHFMAPEVVKREPYGKPIDIWGCGVMTFILLSGSLPFFGTKEHLFDMIVKGRYYMKPRQWDHISEPAKDLIRRMLRVDPKDRITVEQALSHPWLIDRDRVTPKVHLQESVEELKRFNSRRKLKGAVLAAVASAKFTSFYSDPNTKHITDFADEDPTSSGAVAQVLDSLEEIQCLTDCDEKDLDFLHGIFEDNQLHSLLNLYDKINTKSSEQMPNKKDIPSDSVQRSKDILELLQRSPQDSQESYELQAILAEPHFRALLQAHDVVAHEVYSDAAIRVTPPPTSPFLNGREEMQSPNGDVEPMDSVTRVRLVQFQKNSDEPLGITLKMNDDRRCIVARIMHGGMIHRQATLHVGDEIREINNVSVANQTVENLQRMLRELRGSITFKIVPSYRNAPQPCEIYVRAQFEYDPGQDDLIPCQQAGMSFRCGDILQIISKDDHNWWQARKEGEPLNGTAGLIPSPELQEWRVACLAIERAKKEQQASCTWFGRRKKQYRDKYLAKHNAVFDQLDLVTYEEVVRLPAFMRKTLVLLGAHGVGRRHIKNTLITSHPDKYAYPIPHTTRPCKKDEENGKNYYFVSHEEMMTDIATNKYLEYGTHEDAMYGTKLDTIRKIHTQGLIAILDVEPQALKVLRCAEFAPFVVFIAAPTITGMNDMHDNGLERLGKESELLRQAYGHFFDLTIVNNDIEETIRTLEQAMEEICTTPQWVPVSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B424</accession>
    <name>A0A914B424_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038071051.1">
        <property type="nucleotide sequence ID" value="XM_038215123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B424"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215123.1">
        <property type="protein sequence ID" value="XP_038071051.1"/>
        <property type="gene ID" value="LOC119739964"/>
    </dbReference>
    <dbReference type="GeneID" id="119739964"/>
    <dbReference type="OMA" id="RDACECD"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF100">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037691565" description="Phospholipase A2" evidence="9">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="10">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="160" mass="17658" checksum="3AA4F2D0C33CEB20" modified="2023-02-22" version="1">MKLLLLFVAVASVSGREIGKRSVLQFNNMNSCSVGISFDQAVTDYLGYGCYCGFGGSGVPRDETDQCCVAHDNCYKAATSNGCTMAQRYYIVYDYESPIGSDGKCKLTCKALSDYPADDIDAQCKAFMCNCDREGAECFAKARPTFDSKYINWSNLFCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4L2</accession>
    <name>A0A914B4L2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070744.1">
        <property type="nucleotide sequence ID" value="XM_038214816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4L2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214816.1">
        <property type="protein sequence ID" value="XP_038070744.1"/>
        <property type="gene ID" value="LOC119739763"/>
    </dbReference>
    <dbReference type="GeneID" id="119739763"/>
    <dbReference type="OMA" id="DWNTHEP"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134964" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="19522" checksum="2A1A4739DD5E6830" modified="2023-02-22" version="1">MVVSKRFIFGLISLHLMMGCTGGNEMCKASIGHGWACPPTWYQWGRKCYKAITEHLTWSEAKDECIKMGSVLVMPQSQEETEFLVQLQQSNFWINCNDLQEEGTWKCENDEVEFRDWSTGPQWLQPDNLYDEEHCAEMWVDQEGKWNDVPCDAQRPAICIQPAPQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4S2</accession>
    <name>A0A914B4S2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071067.1">
        <property type="nucleotide sequence ID" value="XM_038215139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071068.1">
        <property type="nucleotide sequence ID" value="XM_038215140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4S2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215139.1">
        <property type="protein sequence ID" value="XP_038071067.1"/>
        <property type="gene ID" value="LOC119739973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215140.1">
        <property type="protein sequence ID" value="XP_038071068.1"/>
        <property type="gene ID" value="LOC119739973"/>
    </dbReference>
    <dbReference type="GeneID" id="119739973"/>
    <dbReference type="OMA" id="MIFAIYK"/>
    <dbReference type="OrthoDB" id="10193813at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="135" mass="14286" checksum="18F5D54534E041AC" modified="2023-02-22" version="1">MIDQAGLWAGTGILCAMLVLLIIFAMYKQYSGTLALPPRKPEAKPDGKTDGKTEDKTEQGKDQVADGNSAKPPPPYPSVDDGPAAYTYDQPVDDGLDGVDVAVEVHGTEAACAGREPEASVPYVYDQAIQLETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5U1</accession>
    <name>A0A914B5U1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071185.1">
        <property type="nucleotide sequence ID" value="XM_038215257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5U1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215257.1">
        <property type="protein sequence ID" value="XP_038071185.1"/>
        <property type="gene ID" value="LOC119740056"/>
    </dbReference>
    <dbReference type="GeneID" id="119740056"/>
    <dbReference type="OMA" id="MITIPYS"/>
    <dbReference type="OrthoDB" id="111250at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="314" mass="35633" checksum="A911848C65C68ACB" modified="2023-02-22" version="1">MAKKGVHGSSLWNFAEEHLTCSICYELFDTPKTLACLHSFCENCLLQYHDGYSGELLCPVCRQADSTPLGGVESLTTDFKLVNMVEAVRQEDKQTAPFCSEHAGKPCRAYCQTCEELLCLNCLAESDDHSQHVLEEVREVVDGKRQAVKEHVPKYQAFIGEIVAAMDTTQKLEQDFNSALDITRKAVQEQAAKKIAKVNKAKNKLLDKIQQIQSKRKERFAENELQLMVMRNTFQEIIDHAVDAMQESNDYDFLKMYPRLNNDFKYLTNTSLPSIDTNASFLKFNPRTFGTMLGKLSTERTKTDSVFSVCSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7E2</accession>
    <name>A0A914B7E2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072083.1">
        <property type="nucleotide sequence ID" value="XM_038216155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7E2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216155.1">
        <property type="protein sequence ID" value="XP_038072083.1"/>
        <property type="gene ID" value="LOC119740750"/>
    </dbReference>
    <dbReference type="GeneID" id="119740750"/>
    <dbReference type="OMA" id="CINAMRR"/>
    <dbReference type="OrthoDB" id="10054042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="76"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="43688" checksum="DBFA24CC81134ADB" modified="2023-02-22" version="1">MPRDSPVSRLILQHIHKSVGHLGKNSILAELRRHYWIIGAPSIIKGIVSRCVTCRRYQAPAEQQKMASLPRERLALNEPPFSKVGMDYFGPFEVKRCRSMVKRYGVIFTCLTSRAVHLELAHSLDTDSCINAIRRFSARRGSLKSILSDNGTNLVGAEREMREQMRTWNQQKIHDNLLQKGISWQFNPPAGSHFGGIWERLIRSVRKILYSLMREQHVHLSDEALQTLLCEVEAIMNGRPLTECPNSPNDLDVLTPNHLLLQRSGESLPPGLFDKHDKYPVKQWRQVQYFADLFWNRWSKEYLPMLQERQKWTHPKRNVTVGDIVLVVDSSPRNSWALGRVLEVVKDKNGFVRSVKLKTKTSTLVRPVTKLCLLVEGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B896</accession>
    <name>A0A914B896_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038071652.1">
        <property type="nucleotide sequence ID" value="XM_038215724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B896"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215724.1">
        <property type="protein sequence ID" value="XP_038071652.1"/>
        <property type="gene ID" value="LOC119740424"/>
    </dbReference>
    <dbReference type="GeneID" id="119740424"/>
    <dbReference type="OMA" id="RNEHWME"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="44453" checksum="2D7AD9626FE726D7" modified="2023-02-22" version="1">MAVCMQPARRLGRMIGNKRIFVCCVFLTLAAVVYFVVKQPHGYPMYSGRILQMSGKGLDLQDTRQLFTLNPPDTNHSRSWEDEQVHRRKLISDTCRAAKKRSKDIYPRLEYDFSKVHSERWLKFLLVVDSLKMVYCYVPKVGTTSWKRLLLVLEGRVNSTEELGQKKTHNLTVSFMRNLNSYTPEEAKWVLTNYKKFLFVRNPFERILSAYQDKFQNDYPASKIFRTVWSEMIIRYSGGDLSEARQRRQDGTLNVTFPQFARFVADSNSLVSGGRVYNQRNEHWMEAYRVCHPCAIDYDWVGHYDSMHTDADRILRAVGVDTAVRFPNFTTNPTGSSSYDTLRRYYSQLSTEEIVAIYRNYILDFTMFGFDIPEPIKAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8X9</accession>
    <name>A0A914B8X9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038072449.1">
        <property type="nucleotide sequence ID" value="XM_038216521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8X9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216521.1">
        <property type="protein sequence ID" value="XP_038072449.1"/>
        <property type="gene ID" value="LOC119740982"/>
    </dbReference>
    <dbReference type="GeneID" id="119740982"/>
    <dbReference type="OMA" id="RIARVWT"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="110" mass="12483" checksum="BF181F96754BF2B5" modified="2023-02-22" version="1">MGPKNSVYEGGVFFLDINFSPDYPFKPPKVKFRTRIYHCNISSQGTICLDILKDNWSPALTISKVLLSICALLSDCNPADPLVGNIATQYLHSREDHDRFAKTWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD02</accession>
    <name>A0A914BD02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073312.1">
        <property type="nucleotide sequence ID" value="XM_038217384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217384.1">
        <property type="protein sequence ID" value="XP_038073312.1"/>
        <property type="gene ID" value="LOC119741576"/>
    </dbReference>
    <dbReference type="GeneID" id="119741576"/>
    <dbReference type="OMA" id="KRNERHA"/>
    <dbReference type="OrthoDB" id="10039923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="93"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="43793" checksum="CB0EB5D16264E2CC" modified="2023-02-22" version="1">MNMFTVTSEMATTMVPENMTFVSNMSSDFLSSDFTTSDALDATSVSVNSNMTTTAMMETTTQGDGRNFRFEDPVQRIIIGCVYSLVAVVGFAGNFMVILAVILSRKLQTRTNAFVVNLAVADLVTCSTAPFTALALFSMNGWPLPLIVCSVMAGLFYTSLACSIMNLALIAINRFVLITKSSKTYRSVYTPKKIAAMLVFTWGYPALVCSFPLFGIGKWGYSEKYKTCTQDTSHETSDLFSLLGSALMYPIPLIILFVCYFKIYRHITNHMKKLSGKGVELAETSNSSTASTKRLTRNRPASFSKRQVEITKNLFYVVCAFVACLAPFAIALMIPPSDPVIPWTGMIIIFNSAINPIIYGAKHPHFKEVFRHMLRCRYHMIPEPSGCLRKIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD30</accession>
    <name>A0A914BD30_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073906.1">
        <property type="nucleotide sequence ID" value="XM_038217978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD30"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217978.1">
        <property type="protein sequence ID" value="XP_038073906.1"/>
        <property type="gene ID" value="LOC119741989"/>
    </dbReference>
    <dbReference type="GeneID" id="119741989"/>
    <dbReference type="OMA" id="PAFIYNE"/>
    <dbReference type="OrthoDB" id="6116165at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052129">
        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908:SF8">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036781439" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="264"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="44302" checksum="D5D361C227551F3B" modified="2023-02-22" version="1">MEAKRWLLLLLFVGLASADHSSEEQDCHEECTNGCFGPGPEECCHEQCHEGCTDSTDVGCKECRTVRVDGTCQDSCGPAFIYNEVTLELEPNPEFKFQHGQDCVEKCPKFAFTEGFRCVDRCSPGYRPEGDQCLRCGWACPKQGEVNPLVSDQCDGVKQYEWGVINRKNSPTGNVTCTQVLIGPPGSTLKLKLTDVDIHNAIDEKLVLVADEYRQSFDRETYATTLDLQTSALIVQHRTVATGNGYILAYNFMPPEGEVTDHGCDQVLTTNSGSFKSPGYPNKYRAREHCTYHIIVDPGMRVEVVFERLYLQGDEPACLADKMEVIEPILNTHVTHCGRKKPPFTIISKTNCLVLKFTSDDSRNFKGYTATFKAVEVPEGEKEDFSVDTEEDLPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG32</accession>
    <name>A0A914BG32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">Exonuclease 1</fullName>
            <ecNumber evidence="18">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">5'-&gt;3' double-stranded DNA exonuclease which may also contain a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR).</text>
    </comment>
    <comment type="function">
        <text evidence="18">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="18">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_038075218.1">
        <property type="nucleotide sequence ID" value="XM_038219290.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075219.1">
        <property type="nucleotide sequence ID" value="XM_038219291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219290.1">
        <property type="protein sequence ID" value="XP_038075218.1"/>
        <property type="gene ID" value="LOC119742994"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219291.1">
        <property type="protein sequence ID" value="XP_038075219.1"/>
        <property type="gene ID" value="LOC119742994"/>
    </dbReference>
    <dbReference type="GeneID" id="119742994"/>
    <dbReference type="CTD" id="9156"/>
    <dbReference type="OMA" id="HERTTCA"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000096">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 18" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 18" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="21">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="20">
        <location>
            <begin position="138"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="337"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="614"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="747"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="813"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="747"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113782" checksum="2577B9C2FE9C8861" modified="2023-02-22" version="1">MGIQGLLPFLKDATHRVNVRKYSGYTVAVDTYCWIHRGAFGCAMQLAKGEETDMYVRYCLKFINMLRSMDIRPILVFDGSHLPAKKSVEESRRERRELYSKKGKQFLREGKVSEARDCFSKCINVTPRMALEVIKAARSLGVDCIVAPYEADAQLAYLAISGMAQAVITEDSDLVAFGCPRIIYKLDLNGNGLEIVSSRLNQAMKIGDRFSLDKFRYMCIASGCDYLASLPGIGLGKAKKLFQNATNPDITHVLKRLPIHLKMKVTVPPEYIEGFLRANNTFLYQLAFDPVKRRLVPVHPYSAELDKESLTYAGPYCSSELALQQALGNIDPNTKNKIFDFQPERNKPYDKSNPRHRLSIWHKDYRPGPDFSEGDPAEVQRPKTQGKEVTLMVNGLKLDGQQRKRPRPDADEDDPSNEDLTSLYGSPKSKRHLADPNLVVPETPEDEDKVPGKTGPRNRNPFSKEGRLRDSPPKSAVGFGSEERVVKTLSRRNIFAKGRTGGSSRLDLLKSSTVVTSRFFATEPNPVLHEMAQADESDPERDCKLLDSQAPSVTDTSENETNEDDGTSGAETMQNGNVQIEKGSKASTLNKLQRFQRATSAPVLPFTCSAPTLSSEETAKEPHLSGSQDFFTKSQELDVESHQVGSQESSQTSVKAFTKKGVFSWSRKTTSVTSLKEGGRARSFRSLKEFKRQTVTAKLERSDSKGQEGATDFDSSQEGWSQESCSVSLESQQSNLCSIDTDSLSLSQFSSQPHNNSKTCGMGETNSSQINSFQSQDQDDVVEETLGPRESEEPNNNCSPLRGIEEHLMRINNGQSHEEVLPNQTSDSDKDIDILDSVMDVDSDSQDPKVQHRGTVDPSKLSEPTSKIGAKRGKMASSLDEKEEFIDLTSESDENTPPLEKTKRNTSTGKMKKMKSNSDLEDTPTLPVFPKLPGSTKLNGQCKASGLSRRQKSKQTPKADENRGGGTRQQTLFAFMKKSSERRKDANPTAPLSPSKQNIICDETPEGDSSLCSKGIVRLQRNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGW8</accession>
    <name>A0A914BGW8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075329.1">
        <property type="nucleotide sequence ID" value="XM_038219401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219401.1">
        <property type="protein sequence ID" value="XP_038075329.1"/>
        <property type="gene ID" value="LOC119743060"/>
    </dbReference>
    <dbReference type="GeneID" id="119743060"/>
    <dbReference type="OrthoDB" id="5310573at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35841:SF1">
        <property type="entry name" value="PHOSPHONATES-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12974">
        <property type="entry name" value="Phosphonate-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="161" mass="18369" checksum="E41A4CB3E50B682F" modified="2023-02-22" version="1">MDVIGRRSRYQMFEDLRGSVWAYNYVHSLSGFGITHRGLEKIGENKAIFFGKIIQSGSHLKSIQMILNKTADGTGIDSNTLALQMKAHPELRDKLHVVTSWEPLPVYPGVVNSELPEDLKTSITRHLLNMHLDPKWQAQLNQYMVSKFVPVTLDQYKGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIH2</accession>
    <name>A0A914BIH2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076088.1">
        <property type="nucleotide sequence ID" value="XM_038220160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220160.1">
        <property type="protein sequence ID" value="XP_038076088.1"/>
        <property type="gene ID" value="LOC119744287"/>
    </dbReference>
    <dbReference type="GeneID" id="119744287"/>
    <dbReference type="OrthoDB" id="10212044at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036884639" evidence="3">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="19282" checksum="E0049B1B6540B4AD" modified="2023-02-22" version="1">MEIKLIWIIVLAAVSLGQISQCGPRSMKNIVHGHESGLGLPHNKVAIVSRSAFRGGDDTKQYPLQTTRSSYKPETSDKMSSLPKKRKRKMRMIRHKRWFGSKEAVNKAVENADEIADNLLRHGHKAMREHHTRERLETAAARRTTFAVCFGIMGCCFVCTVLTVKKLCSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJN5</accession>
    <name>A0A914BJN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2'-5'-oligoadenylate synthetase 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076125.1">
        <property type="nucleotide sequence ID" value="XM_038220197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076126.1">
        <property type="nucleotide sequence ID" value="XM_038220198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220197.1">
        <property type="protein sequence ID" value="XP_038076125.1"/>
        <property type="gene ID" value="LOC119744325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220198.1">
        <property type="protein sequence ID" value="XP_038076126.1"/>
        <property type="gene ID" value="LOC119744325"/>
    </dbReference>
    <dbReference type="GeneID" id="119744325"/>
    <dbReference type="OMA" id="RWYKQKL"/>
    <dbReference type="OrthoDB" id="415134at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF7">
        <property type="entry name" value="2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="2">
        <location>
            <begin position="169"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="344" mass="38437" checksum="B6E4643D7D3FA958" modified="2023-02-22" version="1">MGNWFSTGPEPWCLDPSSLERWYITNILEGTQKFNSDCSEAVDRLLGSLNIKCVTAGKNLLDTPDVIKGGSLGKGTMIGGLSEVDLVAYINPSHLAPICSSSTQDYRTQLKAVIDELKKALGRLKNVGIRRSDAYTISFVIEVTGRRFLEVDLLPTAENFHGYGLGPSDIYKEMLQLSGYDRGFYSASLVKFQWDFVKNQPGYVKELISLVKFWACTSLPRALQKSYPLELITIYRWENAGKPAYFSKAQGLKDILKAMTALQVLRHFWTDMYDADLAEQAITKLGHRNPILLDPANPTNNACWVYQKGDDIDVIAKAAESSLQTVLLRDVIVYANWSGRITSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK08</accession>
    <name>A0A914BK08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Triosephosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038076439.1">
        <property type="nucleotide sequence ID" value="XM_038220511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220511.1">
        <property type="protein sequence ID" value="XP_038076439.1"/>
        <property type="gene ID" value="LOC119744539"/>
    </dbReference>
    <dbReference type="GeneID" id="119744539"/>
    <dbReference type="OMA" id="IEKNGTM"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="27099" checksum="0D670FEC723ED509" modified="2023-02-22" version="1">MASGRDFFVGGNWKMNGSKSSINEILHFLKEAEVPENTDVVVSPPAVYLSYVQERLPAKISTAAQNCYKVDKGAFTGEISPAMLLDLGLSWVILGHSERRHVFGEKDQLIGEKVQHALSKGLKVIACIGETLEQRQQGQTQEIVFHQTKAIADNVTDWDQVVIAYEPVWAIGTGVTATPDQAQEVHLQLRGWLAENVSAAVAKKTRIIYGGSVNAGNCQELATKPDVDGFLVGGASLKPDFVKIINARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK92</accession>
    <name>A0A914BK92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075872.1">
        <property type="nucleotide sequence ID" value="XM_038219944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219944.1">
        <property type="protein sequence ID" value="XP_038075872.1"/>
        <property type="gene ID" value="LOC119743523"/>
    </dbReference>
    <dbReference type="GeneID" id="119743523"/>
    <dbReference type="OMA" id="DYSDHAS"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="283" mass="30951" checksum="CF9D13557995E358" modified="2023-02-22" version="1">MLTEGRLYVGSLNPGTSKQDIESEFGRYGSLRDVWLARNPPGFAFIEYDSVADAEKAMRDLDGANILGSRIKVEPSKGHQRGGRGGRGGGMRGGGGDRRGGGMRGGSRGGSFRGSRGSRDGDSRGGRGPPSSYSSYGDYPARGGAGAYRDEPKARYSSDPYGSRYDSAAYRSRSPIRRRSPPPTRGRDFGSREYSTMSREYGSGRDYGAGAADYGTSARDYASPRSYAPRDSTRDFDREYRSPVASSGAGARYDRSDFDRYSRYDRAPATYNDRTRRSPLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK94</accession>
    <name>A0A914BK94_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin polyglutamylase TTLL4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076529.1">
        <property type="nucleotide sequence ID" value="XM_038220601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220601.1">
        <property type="protein sequence ID" value="XP_038076529.1"/>
        <property type="gene ID" value="LOC119744595"/>
    </dbReference>
    <dbReference type="GeneID" id="119744595"/>
    <dbReference type="OMA" id="ANGRAYH"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="867"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="107319" checksum="E225638CA1E6FA63" modified="2023-02-22" version="1">MATPNQIKEIKATLQRGLETLALSGNIKPLPLRQQTSRPLLRSKLGEGPRVPVWGDLDNNNISNYGGVDQNGFCRTSEEFNKIRNDLNNVTVRSPQRTKTTDGLVRAKSELGARGSGGAASDSLRSKPPIPTSRTLIRPISGKKPLNEPRSKFALQGSQTKKQPKTNFKPKPPPDSPGKEPPSSPQRQTSRESSGSEGSVRRSLGSKINRRSRISSSEDAEEWSDIDEVENEDDDEYEPSGSERMPGDGASFDDFDEDDGMDGIDGDDLDEDDESDGYSIASNDSRYQLTNLPLPAASGKSPKPQDGERVSLSSRAGSRMFQYLTTGADDALPALSPSLFSHIPPTINFVGVEEKAVQFPWEIRKLLKWRMSPITPNVIKNCIARSGFRATRKANEWLGYWGKHMKANAFKVVREYQKVNHLPGSFQIGRKDRLWRNLYKMQVHFGKRDYGFFPQTFCLPYDLKLLKRAWEDGGTKQKWILKPPASARGIGIRVVHKWNQIPRRKPVIVQRYLAKPFLINDSKFDLRIYVYVKSYDPLKIYVFQDGLARFATMKYSASMKNLSNKFMHLTNYSINKKNADFTPNNDYTACEGHKWGLKALWGYLKPMGIDTVSVWETIKDVVVKTIISVDSTVNSMVKLNVKSRYCVHELFGFDVMLDENLKPWILEVNISPSLHSNSPLDVSIKGEMIKDLLNISSFHVPDKRDIYSILTPTSNSASKIRGSDIFMDKRLYQTPLSNDERAKHVFYTQKHIDEQCRMSILDTLTPDDLRILTEAEDEYSRCGGFERIFPSPTSHKYARFFENPRYYNILLDEWVRKYHRQHAKGLSLLEEYCQEGIHLSTGKDNSHVRQPWSPAFTPRFSPWTPISSIIQSHDPRTSSAPVTSAPSPTTGLKKSSSTNNLPKIRRRGLAKPRALSSTGSAASLTKSPAQPHPPRGLYAPQRRVVTGATTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKI5</accession>
    <name>A0A914BKI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076619.1">
        <property type="nucleotide sequence ID" value="XM_038220691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220691.1">
        <property type="protein sequence ID" value="XP_038076619.1"/>
        <property type="gene ID" value="LOC119744643"/>
    </dbReference>
    <dbReference type="GeneID" id="119744643"/>
    <dbReference type="OMA" id="WIEEKMW"/>
    <dbReference type="OrthoDB" id="19300at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09919">
        <property type="entry name" value="SH2_STAT_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16855">
        <property type="entry name" value="STAT5_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.532.10:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000029">
        <property type="entry name" value="Signal transducer and transcription activator 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.630:FF:000003">
        <property type="entry name" value="Signal transducer and transcription activator 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046994">
        <property type="entry name" value="STAT5_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0010">Activator</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="579"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="793" mass="90681" checksum="7673B747CE53ECCB" modified="2023-02-22" version="1">MSLILKLQQLQGPAIQQMQLLYQQNRFPMEVRYYCAPWIEAQQWGNIDTDSPSSEPAATILLQQMIQQINEKAEALTGEDKFFLRMKLSNFATELYETYVNDPLKFVRVVRHCLEKEQRLVDQDTNGVQESMEQVMPVPDSHNEIESTLQNLKYKTQSQEKQLSDMQQKQELFAVKVQETRCMLENALDQMQQQYPQQDDPNRRVEFTRFNQKKMEVNSVLQTEAQQLMGMRIQLADMHKETFMLLSQVQSKVLNDELKIWKRQQQLAGIGCSPEGSLDILQSWCESLAEITWQNRQQLKRIEQLKQQLPMNMPAQEMPDLSNSFTGLLSALVSSTFVIEKQPPQVLKKETRFSAAIRLLVGGKLNVHMNPPQVKATIISESQAKDMLHNENANFNDTSGDIINNSGVLEYHKDSGVLNVTFRNMSLKKIRRADRRGTEFVTEEKFTLLFRSHFSVASGELMFQVRSLSLPVVVVSHGNQECNALATILWDNAFGDCSSGRVPFAIPDKVPWPDMAQALNSKFMAINGRSLSNENLQYLAMKAFSGQSVQTDDFNSMYISWSTFNRDPLPGCTFTFWKWFHGVLELTRKYLRPPWNEGSILGFITKEHAQELLLTKQTGTFLLRFSDSKLGAISITWVNEDPTTGERQVLNLLPFSSEDFHIRSLADRIHDLPHLTNLFPDIPKDTAFGNFYTPVDEVLPQSGDGYVSSVLVSKIPQITAPQSYAMENPGSVEPASPQQQPQNREQDFVNFTGMDDFGEMLNDRDRDEPQLAPDISDLLKDFDTFDMMDPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKK9</accession>
    <name>A0A914BKK9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076644.1">
        <property type="nucleotide sequence ID" value="XM_038220716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220716.1">
        <property type="protein sequence ID" value="XP_038076644.1"/>
        <property type="gene ID" value="LOC119744658"/>
    </dbReference>
    <dbReference type="GeneID" id="119744658"/>
    <dbReference type="OMA" id="CIFACCC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="18211" checksum="50E867ECB335CACD" modified="2023-02-22" version="1">MMEDSGEGPEGDRPADNRGFSTPPPGGVSLEDVARELVDKETKTTDDGDDDDVAMATGDKASTDADHEKTEQTTMKDEVATEMKNPKNVRKCDDETAKTTSTGRGLVRIFVRRRNKQDKEAKNKESRKESRSEKKIKKQEERMKKHSKIVVCIFACCCVQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKS9</accession>
    <name>A0A914BKS9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076072.1">
        <property type="nucleotide sequence ID" value="XM_038220144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220144.1">
        <property type="protein sequence ID" value="XP_038076072.1"/>
        <property type="gene ID" value="LOC119744275"/>
    </dbReference>
    <dbReference type="GeneID" id="119744275"/>
    <dbReference type="OMA" id="LTLWANE"/>
    <dbReference type="OrthoDB" id="10638548at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="210" mass="22022" checksum="BE98A2B7731A99C7" modified="2023-02-22" version="1">MSIPAGVLDHDDLTQRGFGITTIVLVVGIFKSKKGLLVPFIVAQTVMIGVFVALVVILVVNLANGNNIYYFDILTLWANELGGDPIFIYRAVYWPLVALLACAVILELGCLLCVVSQYQELRDGRGTGPLPMTTTTTVVMVPQGSYVNQGGDTGGEPGTTPNTEEQATTSTGGGRKKPARAGKSSGDGPSGASPPKPDHSSSSESESDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL45</accession>
    <name>A0A914BL45_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="24">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 24">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="24">Golgi apparatus membrane</location>
            <topology evidence="24">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 24">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="24"/>
    <dbReference type="RefSeq" id="XP_038076506.1">
        <property type="nucleotide sequence ID" value="XM_038220578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL45"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220578.1">
        <property type="protein sequence ID" value="XP_038076506.1"/>
        <property type="gene ID" value="LOC119744582"/>
    </dbReference>
    <dbReference type="GeneID" id="119744582"/>
    <dbReference type="CTD" id="2590"/>
    <dbReference type="OMA" id="NVPMGSI"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000018">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000026">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 24" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16 24" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 24" id="KW-0430">Lectin</keyword>
    <keyword evidence="20 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="25" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037610459" description="Polypeptide N-acetylgalactosaminyltransferase" evidence="25">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="26">
        <location>
            <begin position="447"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="579" mass="66106" checksum="FCCFF3D8E688B58E" modified="2023-02-22" version="1">MGNMMRRKSRLILLMALAWVVGMFLYLHNSPDEDQEVPKEAAKRFKFIVEDPGKDKLVVGDAGKVVGSNGINQHGQPSELDKSWQNFDQKAYIAKTLVKKGEDAYARNKFNQKESDKLKMDRDIPDTRHAQCRNIDWHHVLPATTVIITYHNEARSTLLRTVVSVLKKSPPELIEEIILVDDYSDEPQDGKLLLGIEKVRLIRNERREGLIRSRIKGADAASSSVLTFLDSHCECNENWLQPLLKRIQENYKAVVSPIIDVINMDNFQYVAASADLKGGFDWNLVFKWDYMTPTERASRRSNPIAPIRTPMIAGGLFAISKQWFEESGKYDMMMDVWGGENLEISFRVWQCGGTLEIIPCSRVGHVFRKQHPYTFPGGSGNVFARNTKRAAEVWMDEYKQFYYAAVPSARNVPYGSIKSRVELREKLQCKPFSWYLDNVYPELRIPDKQDLAFGALQQGSMCMDTLGHTEDGVLGMYECHNSGGNQEFSFTKEKVIKHTDLCLTASDSTSGSTVLLRSCKGYHSYQKWEQAESNRIFKLQGTNLCLDSKDVKTIGLTIHTCERRVITQQWKFSMGNLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLB0</accession>
    <name>A0A914BLB0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076566.1">
        <property type="nucleotide sequence ID" value="XM_038220638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLB0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220638.1">
        <property type="protein sequence ID" value="XP_038076566.1"/>
        <property type="gene ID" value="LOC119744607"/>
    </dbReference>
    <dbReference type="GeneID" id="119744607"/>
    <dbReference type="OMA" id="NTAYEDY"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000023">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="364"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="426"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="529"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="655" mass="72216" checksum="CF9FCE55B4AD6B1C" modified="2023-02-22" version="1">MSSIHIKANMAEANGDPIPEEQKMDEEVQGEAQASDEPMETETYVKTDNYDKYLGMGFSDKVAEKLDQIVTELSGQGLLQDDLLDDRALEALKGLDDESSIGVLKQFSTSDLTHVNNKSAFICGVIKTFRQKSRRPGGAPAPADHKGPDDAKIKEMLERTGYSLDVTTGQRKYGGPPPNWEEDAPGPGCEVFIGKIPKDTFEDVLVPLIEKCGKIFDLRLMMDPMSGLNRGYAFTTFCDKAGAQECVKQLNGHKIKENWQINCNISIPKSRLFVGSVPKNKSKQEIKEEFEKATTGLLDVIIYHGEDKTKNRGFAFLEYDSHRSANTARRQLMSGKVRVWNTMVTVDWADPVSEPDEETMAKVKVVYVRNLAPEATEEIIKEHFKQYGEIEKVKKMKDYCFIHFTEREAAVKAIEEANGSSFQGQEIEASLAKPPTENKKKKERQMKQHQGYPGGRYYDDFYGPMRGGRGRGGPRGRGGFDRGERGFRDFGYGGGYDEGYYGGYPGGYDDPYDYQGGYYDRGYDGFGYGGRGQGVGPRGRGGPRGGRGGMGGPRGGPGNRGGPRGGRSRGGQQQQRGGRGGAGNRGGRGGNRGGNVSGKRKFEGQQPADTKRRNTQGGWGAQPIAQQPLGEYSQSYDYSQSYGDQSWSQDNYAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM24</accession>
    <name>A0A914BM24_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Thromboxane-A synthase</fullName>
            <ecNumber evidence="8">4.2.1.152</ecNumber>
            <ecNumber evidence="30">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="33">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="34">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 35">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="8"/>
    <dbReference type="EC" id="5.3.99.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_038077333.1">
        <property type="nucleotide sequence ID" value="XM_038221405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM24"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221405.1">
        <property type="protein sequence ID" value="XP_038077333.1"/>
        <property type="gene ID" value="LOC119745178"/>
    </dbReference>
    <dbReference type="GeneID" id="119745178"/>
    <dbReference type="OMA" id="EIFSMCM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="23" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 34 35" id="KW-0349">Heme</keyword>
    <keyword evidence="20 34 35" id="KW-0408">Iron</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="25" id="KW-0456">Lyase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 34 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0492">Microsome</keyword>
    <keyword evidence="35" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="19 35" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="34">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="507" mass="58147" checksum="C72D69F8EF1076D0" modified="2023-02-22" version="1">MIGTITIVLLSALLAYIGWRTYDQLTFFGKLGLKGPTPLPIFGNLFGFKIGVYKALQKWTKEYGKTFGISRGARKVIISSDVDFVREIMVKQFTNFADRQGFPLRPEETNFDLLNLKGDRWKAMRETVALVFTKHKMQKMLPMVTECADETVKNLKENEKKTEGVLDIHKYMCEYGIDVGSYCFFALRATSQEDMTVLMNQANAMWIRFKTFYLPWFVIMLFPQLEPIFKYLGCSIHPHESVDYFTQLIKGTMDSRRADPNSSKYMDFLQLMMNANEELNSSATTINGRQLQKRALTDKEIFAMSMSVFAGNTETSPGTLSFIFFMLAMHPEVQEKLIQEIDDVMGGGDDVTQEKVNKMTYMDMVIRESLRLYPTAASLDRVCSEDCVVKGIKIPKGTLVEIGVYAIQTDPDYWKDPFTFDPERFSAENKAKMDPMTWLAFGQGPRMCIGYRFAMVEMIVMLTRTFQKFRLEICAKTENPPTRGTRGLMTPEKGINLRLVPRQEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNV1</accession>
    <name>A0A914BNV1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Receptor-type tyrosine-protein phosphatase N2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077386.1">
        <property type="nucleotide sequence ID" value="XM_038221458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNV1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221458.1">
        <property type="protein sequence ID" value="XP_038077386.1"/>
        <property type="gene ID" value="LOC119745234"/>
    </dbReference>
    <dbReference type="GeneID" id="119745234"/>
    <dbReference type="OMA" id="HMSETDI"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="212"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="390"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53239" checksum="0CCD20FDDECD0766" modified="2023-02-22" version="1">MCTTLSVDHSLANHSPHRLVTVSVTTFDPRSQAIVLSLSRITPTTTHITVLDSPQDDNSTLIVVTVVLVACIVGILIAVITVYCYRQKARIRAKLKGLSSNGGAVEGEATADYQDEGQAQGAELQWGAVEGEATADYQDLCRQRMASKSSEKPEPLSRISSVAMSEGANPSPSSRSSTSSWSEEPVQSNMDISTGHIVLSYMEDHLRNKDRITKEWEALCRYEPDVSSTKVGALAINAPKNRYQNVLPYDHTRVLLNDSTNALSSDYINASTIADADPRNPAYIATQAPLSSTIADFWQMVWEQGAVVIVNLTPMTDADTVHTLYWPSEGGTRYHFYEVHLVSEHVWCDDYLVRSFYLKNTETQETRTVTQFHFLTWPENGIPPSPKALLEFRRKVNKSYRGKACPIVVHCSDGVGRTGTYCLVDMVLTRMTKGAKEIDIAATLEHIRDQRPGAVKLKEQFEFALTALAEEVNAILKALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNY9</accession>
    <name>A0A914BNY9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077207.1">
        <property type="nucleotide sequence ID" value="XM_038221279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221279.1">
        <property type="protein sequence ID" value="XP_038077207.1"/>
        <property type="gene ID" value="LOC119745056"/>
    </dbReference>
    <dbReference type="GeneID" id="119745056"/>
    <dbReference type="OMA" id="NIANYSW"/>
    <dbReference type="OrthoDB" id="5843397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036904675" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="142"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="231"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="49835" checksum="DB46CAB7970962B1" modified="2023-02-22" version="1">MSPTDRFVLSAALLCFVLSFACHLALAEPTIERGPQDAFVREGDTVEFTCDFTNVGNSTIYWYHQESYLSFDRQLYPMPTLPPQLEQRLSIIGDESKDEFTLRITNVQETDEGTYSCLYGSPGALPESAGTAKLILLVAPSPQSPWCSVEPASGAVGDNVDLSCNVQGGKPAPNITYYKENEQLVGPVTNSIRHRYQLKAQDNGVIFTCIMTTPALDEPRNCSAMLQGILPTATILPAVSRVEEGTSTSFQCNGEGLPNIANYSWKVIDTETGHTLPTERYIVSEDGQTLEIAVMENLELVCIVSVPSGLSGNTTARVEVNYREQTTTSVTSTWVQREETTGSSRSTELPKEKPFKQPPCTCPVTDNKMTSTCPVAVASTVMTSVLAVAVIVLIILIVWPRKHYRKYSSFPMGLRMMQAGQGYDIQDDEEQGQETQGFACAAVQEDSDSDGPINSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSJ7</accession>
    <name>A0A914BSJ7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078586.1">
        <property type="nucleotide sequence ID" value="XM_038222658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSJ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222658.1">
        <property type="protein sequence ID" value="XP_038078586.1"/>
        <property type="gene ID" value="LOC119745947"/>
    </dbReference>
    <dbReference type="GeneID" id="119745947"/>
    <dbReference type="OMA" id="WIFRACT"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="46541" checksum="3C57CE36B1F3BFD7" modified="2023-02-22" version="1">MAKWVGRAGSTGRYCGLSLWIFRACTCSRISRSRICGLAFLISVVSFAATIWVFLGGFHATETRQEHVYSQELRLATGRPTQPRVNTASSHRNTSRPFVEKYRHNYSNNATEFFRHLKGVIEQGRGRKPSAKKKREFSVELRRELGDAGNIGVFSLTKNNAQVGTTMRFSIVGANRSISQTLWNYLPEDANFKSGQFQSCSVVGSSGILRGSGCGKEIDRSQYVVRFNIAPVKGFETDVGSKTNFTTLNPSYVKYWLNGFKKQSDRSQFGAILKQFKGSKLWLPAFGNSRFFRVMQLTAAAAFDSKMVQPLIGHPEHHHSVINLWHKMAMKRALPTTGMYFILSLFDVCDQINVFGFWPYEKAINGSEVPYHYHNPSFGKTVHDFDTEFKTLVNLYEQGIIKMHLGSCLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT67</accession>
    <name>A0A914BT67_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038079170.1">
        <property type="nucleotide sequence ID" value="XM_038223242.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079171.1">
        <property type="nucleotide sequence ID" value="XM_038223243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT67"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223242.1">
        <property type="protein sequence ID" value="XP_038079170.1"/>
        <property type="gene ID" value="LOC119746350"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223243.1">
        <property type="protein sequence ID" value="XP_038079171.1"/>
        <property type="gene ID" value="LOC119746350"/>
    </dbReference>
    <dbReference type="GeneID" id="119746350"/>
    <dbReference type="OMA" id="NEECRTH"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16474">
        <property type="entry name" value="RING-H2_RNF111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="909"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137227" checksum="878F22A177A9A0EB" modified="2023-02-22" version="1">MEFYSSNPVMAVASCLPDSGGVEAQVLDRGSQSGPCSTSETREGAVMESEAGVLETDDSLDLCSPHNEDEGLDISPVMSEPLVHPPQSVPSHLIEGHLREIEQVAESAVACQIFSDPGSSRLRYREGQPKPSEVVCLGATAAAASDSPVVISDSGDYNMMSVGNSPVPPLESESYSDYSDEPIPGLVSMRHYKPFKPKILNSSGDGMLSSASGDSDLDRLSSHSISPSGAWLPQGTDAHPGPSEGQGFQPYRRQHPIVLSNKKPRLHSNSGPSSSSFSVSENSAFEARSHLFPNTKEDTEAHRRLSSDHHALPYDPAEPELVDIDLTVRDRDSLDLEDQEDPWASPGTSLSVAHGSATPTFSSTDTGPAPSCADYSDSDIDVVSVDEFDVSGHGNNPSISRDVAWDDPLLPLSGALDFIPPYDEPLPGPSGIMRPSNNETVDLVESSDSENSDESDDDLNLEESHDEADDDIEVVSVDMGSNNDRWGVQSNNACPRKMSGGLKHPLVKGQRKKRPLSPLIVDLTESDGEDPSSSIPELEPVPDTNQEALSDEASIQPPPPPSQAKPLPPCTSCRQLSPQPVISSPVTTTPPPPYHLPRHHHHHHQHLHPRRACMHEGAVPGAPLLHHVGCIYSGGRAACACHSPRTQLQRGSPSVGEHNHTGARERDQDVPAREQKSSAGTKKPVSLGKQLPRPKSKEKKETLPPSADVTPDPQRSSQVSDLHSYQGQLGRRGHSEECRAHNHHAHVHQSGCSVRVQQSGSRPSSFQLHVHHSHNHRRPPTSDSVQQGPTQTTPQVPTHGQAQPQPPPAHHHHPTQRQQPIAEIRLPQQGSSVPLRHQQLYQQQNRMRELQRLHMSRMRDSHFDAVTPYSAQMLRLYHHQQQQQQQQHQQHQQQQENPLEQLEHFYSAPHHHRQQQQQQQQQQQQQQQQQQQQQQQQQSESCQRIMHNAQPPQAHTTYPPGHPLLHHPSPYTQPHSHPLAHALPQAHLHPTLPALQPVQPQPQQMEVEHIEPVVGPAPNIDSSEPLTIPPPFLDSNFSPQHRHLHHHLHHYHHTAPPAPPQQRSTGGFHPAFYGNYPSMADLPPLTAHPFYRAYRVPLMRRMGRGPMYEELVQLSERMGQVNRGASRITIERNTFPHKYHKRKRPAEESSCAEAENSSENATEGASSETNCSKPKITDDDDDEEKCTICLSYFDENEDVRRLPCMHLFHVECVDQWLSTNKRCPICRVDIETKMPKDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTC7</accession>
    <name>A0A914BTC7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038079242.1">
        <property type="nucleotide sequence ID" value="XM_038223314.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079243.1">
        <property type="nucleotide sequence ID" value="XM_038223315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079244.1">
        <property type="nucleotide sequence ID" value="XM_038223316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079245.1">
        <property type="nucleotide sequence ID" value="XM_038223317.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079246.1">
        <property type="nucleotide sequence ID" value="XM_038223318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079247.1">
        <property type="nucleotide sequence ID" value="XM_038223319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223314.1">
        <property type="protein sequence ID" value="XP_038079242.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223315.1">
        <property type="protein sequence ID" value="XP_038079243.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223316.1">
        <property type="protein sequence ID" value="XP_038079244.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223317.1">
        <property type="protein sequence ID" value="XP_038079245.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223318.1">
        <property type="protein sequence ID" value="XP_038079246.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223319.1">
        <property type="protein sequence ID" value="XP_038079247.1"/>
        <property type="gene ID" value="LOC119746400"/>
    </dbReference>
    <dbReference type="GeneID" id="119746400"/>
    <dbReference type="CTD" id="728294"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="15">
        <location>
            <begin position="149"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="585" mass="64785" checksum="13824DD42FC9BCE9" modified="2023-02-22" version="1">MASIRATKMSFKNIHRSMAGHLRPSNSAVQCLPLHNNKTVSTYMYIGTLASNARQINHGSIQAVYTFCDYQKISHCQQLSWRHLATSSAAHQTAREVPLTSTSHPTLERGPFSRVTDDNVAFFQELLPQRVITDEDDLISSNTDWLGSLRGASQVLLRPKTTAEVSKIMAYCHAHNLAVVPQGGNTGLVGGSVPVFDEVILSTSLMNNIVEFDELSGVLVCQAGCILEKLDNYLAEYGYTMPLDLGAKGSCHIGGNVSTNAGGIRLLRYGSLRGTVLGIEAVLADGRVIDCLSSLRKDNTGYDLKQMFIGSEGTLGVVTGVSILCPPRPQSVNVAFFGCDSFSKVLATYKESKSHLVEILSAFEIMDQEALMYVTKYLELRNPLSKEYPFYILVETSGSDGNHDEEKLNRFLEHIMATELVLDGTVATDSAKIQMIWALRERVNESIQRTKVQYKYDLSIPHRVYYDIVPEIREHLRTHHSHLPVCDVVGYGHVGDGNIHINVVVEEFSEEIKQALEPFIFEKTSNLKGSVSSEHGLGFNKRNYIGYTKTNEAVLVMQQMKRLFDPKGILNPYKTIPSVPGVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0C8</accession>
    <name>A0A913Z0C8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nephronectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044120.1">
        <property type="nucleotide sequence ID" value="XM_038188192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0C8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188192.1">
        <property type="protein sequence ID" value="XP_038044120.1"/>
        <property type="gene ID" value="LOC119718776"/>
    </dbReference>
    <dbReference type="GeneID" id="119718776"/>
    <dbReference type="OMA" id="YYCEDSE"/>
    <dbReference type="OrthoDB" id="9946171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938663" evidence="6">
        <location>
            <begin position="23"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="90"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="263"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="641" mass="70181" checksum="D2EDE6533C0CB23A" modified="2023-02-22" version="1">MEKTRQISAGIVLILVLNAAVAANEMSRLFEDMLPYYCEDSEEASCREALRDPGTLLTNVLRRQAGLEALKSSESILQQSLQEGLSLVEVECNFDFASFPIPVPFLCDWTTESNDDINWEPGSVALNVVTKEPGPFSLTVYAISRLNSETSTATAGMLTPMINCSTDGNVYGALQFEYNLRGTEDDNKLKVKYVGKDGVRITIWSSEDDFKSNSWETANVYEFYPSGPFQLAFESTLSPGSETKPYAAVDNVGLQVGVLPSIFDCEGGTPHSVTCGLIDLEGRWQRWSGSEALDKGRGPTTDHTLGTSSGHFTINVKPSLFTPGTTARMQTPEFHRWTNETTCTFRFYYHAKTSGDMEVTVSADYGTEVFPVALNYSETWEEHDIDLTKVSGKYRVTIQVSTSTGNGNHIAIDDVQFLEEDCRGRLFCSSFPCLNNGACWQTLETDYGCNCTKEYEGSDCGINVDECSRDPTLCASDSNRICKDASPGYQCVCKPGTIEYKGKCIAACTDTMCTRKNEVCLQNDNAFSCQCQYGYVESNGECIRDKSEVESGIVPYTFNVLLGTYLGGSLVAVVVAALVVLCYFSCCDEKDDDWKQEAVEANHYNDADVAGGSGLNANGTGQRSPAANGGVELKNRGPEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0M5</accession>
    <name>A0A913Z0M5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045373.1">
        <property type="nucleotide sequence ID" value="XM_038189445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0M5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189445.1">
        <property type="protein sequence ID" value="XP_038045373.1"/>
        <property type="gene ID" value="LOC119719960"/>
    </dbReference>
    <dbReference type="GeneID" id="119719960"/>
    <dbReference type="OMA" id="CTPLIVI"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037157178" description="Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="286" mass="31761" checksum="C44F0B33303AC1F2" modified="2023-02-22" version="1">MAWRCVVNPSAVTMMVEILMRIALSAIFLVTEEMEPFHRVIQPEEMWLYRNPVTNSYTTTRTLFTIISVVPAVVITMFAIFKPDKKDTQQAILAVTLALALNGVVTNSIKLTVGRPRPDFFWRCFPDGKNTLDMKCTGKPDVITEGRKSFPSGHSSFAFAGLGFTALYLAGKLRCFESQGRGSSWRLCLAGTPMLAATLIALSRTADYHHHWQDVLIGSLLGFSVAFMCYRQHYPPIAHANCDRCYASLTPYAPLPPFADSPQSEYELNGVISTAPRNPDASVKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1R6</accession>
    <name>A0A913Z1R6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044630.1">
        <property type="nucleotide sequence ID" value="XM_038188702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044631.1">
        <property type="nucleotide sequence ID" value="XM_038188703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044632.1">
        <property type="nucleotide sequence ID" value="XM_038188704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1R6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188702.1">
        <property type="protein sequence ID" value="XP_038044630.1"/>
        <property type="gene ID" value="LOC119719296"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188703.1">
        <property type="protein sequence ID" value="XP_038044631.1"/>
        <property type="gene ID" value="LOC119719296"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188704.1">
        <property type="protein sequence ID" value="XP_038044632.1"/>
        <property type="gene ID" value="LOC119719296"/>
    </dbReference>
    <dbReference type="GeneID" id="119719296"/>
    <dbReference type="OMA" id="NAWKLIL"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="44421" checksum="06E5BED692FBEEE8" modified="2023-02-22" version="1">MRRIKLTNLLICGIATFLFGATYLAFKEPPKERTAPASERGLGGKVPDLSGNSAVKSRQPLGDDDDALLLPFADRALPRRLLQVPSYMRMLNASTEGIDIDIAWGDIDFHNLDLKTVIVTGLSGYTEEEGVGLVASAQIHMPFKKIIIYDLGVKQRTLDRLSPLCNVEIRKFDYTKYPAHVKILRNNAWKLVVITEALEEFGSVFYAHPHLRFRAPISILFPYVKQMHGFIPSMNDDTPLLEVTHPTTLRLMQVKPAQLNRTRGPGGSRGPGVISGHMLLFVMNSTLANRVLPGLRKCYLRSKCLSPPGAMWQLQRPGKKLHRHHFDQAVLSLMMYKLYGVSWQPREEVQRMMKRLFVVLDEGDPVHELSWSFRCNPPKEEFDPAKLLQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z270</accession>
    <name>A0A913Z270_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045797.1">
        <property type="nucleotide sequence ID" value="XM_038189869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z270"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189869.1">
        <property type="protein sequence ID" value="XP_038045797.1"/>
        <property type="gene ID" value="LOC119720248"/>
    </dbReference>
    <dbReference type="GeneID" id="119720248"/>
    <dbReference type="OMA" id="ENHSKGP"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000002">
        <property type="entry name" value="Carnitine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="646" mass="72690" checksum="9CD4300E04BB8560" modified="2023-02-22" version="1">MLSSVARHFMRQSANISPMAKAAEKTAAMLGRKQAQPGRMFAHQQSLSRLPVPPLQQTLYKYLLAVQPILSEEDYEATKKIVTEFGKPGGYGESLQMALIQRYQKMDNWLAEWWLHKAYLEFRSPVVLHVSPGVVFPREDFRGVDAQLEFSARFIAGVLDFKQLIDSNSLPDDYMGGQPLCMYRYHKILSSCRVPGVKKDSVVSFPPNEPDAPRHTVIGHNNHLFSLVVYDSQGKPLPISEIHSKLKEIVAASPFPAEPVNILTSEHRNTWGKIFKKMSKDKVNRASFEEIKRSIFMVCLDKSVYSELDGQMQVESFANYCAKMALYGGGSRANSCNRWFDKTIQFMIGADGEIALQYEHCTVEGPYIMAMIDHSLHYAHNTPVESSRSSAISTSVPKRLDFNLDCETLEAIEDAKCHIDSLGNDVQISCFSFEPFGKDFCKSQKLSPDAFIQLSIQLAFFKLYGHSTATYETASLRKFQFARTDTIRSATVDSDIFVRAMCESTKKLSEKAHLLRKAILAHREYTNAAINGDAIDRHLFGLKLIAIEQGKNVPEIFMDTSYTAAMHFRLSTSQVPAKHDLTMIFGPVVPNGYGVCYNPQDDHINFGVTAFNTVPETDSEKFSQKLAESLLDMQRVLNKVPPHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3V5</accession>
    <name>A0A913Z3V5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038045395.1">
        <property type="nucleotide sequence ID" value="XM_038189467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3V5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189467.1">
        <property type="protein sequence ID" value="XP_038045395.1"/>
        <property type="gene ID" value="LOC119719979"/>
    </dbReference>
    <dbReference type="GeneID" id="119719979"/>
    <dbReference type="OMA" id="AMMSPHQ"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000015">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF499">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="437"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="631" mass="71329" checksum="D3F23E460C1EF31A" modified="2023-02-22" version="1">MFQARIYPVSASPRCATPSTELETVAVKRNIGCRLGLCIGLQQDTVLKKQQRRQVWIMVVMTLIPIITLAILAVVLMTNSSVYTVRLQWLRNEVGGSVENAGQLIHRLQIERGMTAFYLSSGNREELDKLLGIYEQTDSAIDNISWVNDNPREVPDFFESKERYRAHLVLFRERFVSTGGSNTSIPDIMTFYTTDIDVIIGWLSEGIQLHDPAGGLWSKLISYQLLLLAKEHTGKERAIGSIFYSRGGFSQNDDFIWFMNESVAGKRFLDIALQFSSFLQQALKEAIDNNVTSQIENMRSEIHLNNHQLLEPSLAKGDRWFQNMTHFINDLLQLQTKLGNSIIEELNSDMKWSLSYVVAYAFLLFTVLITGPLIIRGIIRQTHHIQHVGDSLHRKTLELREEKRKSDSLLHEMLPKVVAEQLKLTGQTPAESYDEVTVFFSDVVNFTAMSAISSPMQVIVMLNTLYQSLDALIDRYDVYKVETIGDAYMVVSGAPNRNGRRHAPEMAKLALAIYREMATLHIPHLPDHTFQLRIGIHTGPCAAGVAGSTRPRYCLFGDTINTASRMESTGEPGRIHISQATREALLRVNNDEGEDEEFYVTLRGTLDIKGKGAMTTYWLLERPAVENQQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4A6</accession>
    <name>A0A913Z4A6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046552.1">
        <property type="nucleotide sequence ID" value="XM_038190624.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046554.1">
        <property type="nucleotide sequence ID" value="XM_038190626.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046555.1">
        <property type="nucleotide sequence ID" value="XM_038190627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4A6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190624.1">
        <property type="protein sequence ID" value="XP_038046552.1"/>
        <property type="gene ID" value="LOC119720784"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190626.1">
        <property type="protein sequence ID" value="XP_038046554.1"/>
        <property type="gene ID" value="LOC119720784"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190627.1">
        <property type="protein sequence ID" value="XP_038046555.1"/>
        <property type="gene ID" value="LOC119720784"/>
    </dbReference>
    <dbReference type="GeneID" id="119720784"/>
    <dbReference type="OMA" id="WKTKNTG"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59036" checksum="CAC8852369F8AFA6" modified="2023-02-22" version="1">MAINWGGVAGIIVFYLLILAVGLWASRKNKGSKDQEQVVLAGRNIGAVVGIFTMTATWVGGGYINGTAENVFKPKGNSGLVWTQAVWGYSTSLVLGGLFFAKIMRSKGYITMLDPFQLKYGSRMGGLLFIPALTGELFWTAAILNALGSTISVVLELDMTLSVIVSACIAVFYTFFGGLYSVVYTDIIQLICIFVGLWICVPFAMTNEAVEPIGSTSQEWLGTIESDQAGLWIDSALLLVCGGIPWQAYFQRVLSSKTPRTAQILSFVAGFGCILMGIPSVLIGAVGASTSWNDTTLDLGKIDPYSQTSLILPLVIQYLTPPVISFIGLGAVSAAVMSSADSSILSSSSMFTHNIYKQVFRPKAGKVELVWVMRASIVVAGVIATVLGLSINSVYKLFVFCSDFVYVVLFPQLLCVIYFSKCNTYGSLLAYIVALILRFGGGDSLLGIPALIKYPYYDEEEEVQLFPYKTLSMLSSLLTILVVSYPLDYLFKKGTIPKRYDFFRCVVNLPSAKDQVDFDDDEVKYKLKRRDSTDSPAEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5A7</accession>
    <name>A0A913Z5A7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HEAT repeat-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046902.1">
        <property type="nucleotide sequence ID" value="XM_038190974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5A7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190974.1">
        <property type="protein sequence ID" value="XP_038046902.1"/>
        <property type="gene ID" value="LOC119721083"/>
    </dbReference>
    <dbReference type="GeneID" id="119721083"/>
    <dbReference type="CTD" id="399671"/>
    <dbReference type="OMA" id="YATQSHN"/>
    <dbReference type="OrthoDB" id="5980716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF20">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136419" checksum="481066C2FB81CB67" modified="2023-02-22" version="1">MAMDRMPQHPELFPCGDRIKVPQVGADASNFKGKFSLADLRPTPYFSQRQNMLRRDYLQKISSDLLFSEDVVKTHAAHTLPYDRESIREAYDYSDIVQREKKRFVGPVGRYNPRTTNQHLPCHIKKRSHHRLEPIRKQKLKPIGAAANEEDKETVKTDSDSRLGPKSPAFLTEDPMIEASAEEANATQARTKYSQNWDEHLLMHLSKNTARWIVGEQTSEGPQKDKLHRLLVDMYGEPSGHLDTLIHDEVSVSDMSVSRETVLTGSKTGSKQSTGQQQQQEDATTAAGKDERGQVEDDVNSRSLAAFYRQPDAVRRQQKQLAKEVAGSLNSTAREIKVTRKKPKPPPTLKDVMNPAVGDTIHDTQNQFEQEWLSGAQQVLHHDTSRLLLDTGNLYQITRQEDFPQDPASWSGEGASEKTKQKGKAPGPTEAATQKGHRGYKKWSQLPQAIQGDVSLTIHEAGYDPEAHREPDPSEMRQHKQNPALVKLVDEWRTKWHLGNKWYDSSIDDLVRDMSDIHEHVRLQAIATIAKAATYRPPAEPGVPIKSSFAKKALAAINQRKNTSDSEGVLPDALLQCVEKVLGDTSRRVQVTAAIALYTLNKPNEEPSNVEARRILNDVMRAGSEPERWAAAQCLAHAGVCDSYVVSELIQQLLASEDAIKNERCVSLLARLSANSSVVHSMVGEQLNSTSWRHRIIACRVLPRLNGTINKDITHKLSNLMWNDWHHEVRKAAAQTMGRTGHGKEVHDDLRDRLLEGNERDRIDALNKIAHLGIMTARLLPAYLQCFSDAYIAVRIAATNTASLLSLEDPKVTQKLLFLTQFDNNWKVKAHAVKALGDIGKNSEPIQEAVLWAVRFESEPGVRAEALQTLVKLKIGGKHIAAMLQDKLLVEPDQLVRVQLAIALQSMGVSPTGDMEMVQQIKDEVRRLCTRYNIAAKITQNEMEEGLNEQRERFFNESPRTPDPKAKSRKNIPPRSSISTKQSQRSITTPSIFVDSEAEESKTSDDEDFSPTKPTPDIALPRTPSAGQDRGSLLSPLATSKTPGSASSRGRSPVEKLEKLIELYEGSCSVKEYKDYVRPEGEEEDADVEQGGSKDPAVKLETIAESIEEEIRILRQESANANRIPEEPTPERQEQAASRSSPIQQQPGMTPDPSPAGESPVQVPALDINSNPVVCEDEVHVAVADKAAGKVEALVTGDPTERMSVEISNQTESQDTLQGPDSPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5H6</accession>
    <name>A0A913Z5H6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Src kinase-associated phosphoprotein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046030.1">
        <property type="nucleotide sequence ID" value="XM_038190102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5H6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190102.1">
        <property type="protein sequence ID" value="XP_038046030.1"/>
        <property type="gene ID" value="LOC119720440"/>
    </dbReference>
    <dbReference type="GeneID" id="119720440"/>
    <dbReference type="OMA" id="SIPCEDE"/>
    <dbReference type="OrthoDB" id="243840at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000734">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="147"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="461"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58684" checksum="15AD6CC599D1FD6B" modified="2023-02-22" version="1">MPELEHVIEEVKRFLKDVETYLSITLKKEKLKRETNTKREELLKDVASIIVKLSPPEIEEEEQEEYADVDVPSSLSADKIQEEREDECDDIYEDTVPESTHSNDSSQNSDDQDDGEEQEDRSGMFDLDGDPYGDVKVDPIAASDLTASSKEGYMDKKRKEGQFGLQAWQKRYCVIKGNILYYYKKKTDKEQCNQIVLTGYQGREAPDFEKKNKRKDLLFEVVCPAKRSYQFIAQNKKDLQEWIKVIAVASKLGPSLVDPLAKSTPNNSGGSEDLSEELYDDTSAPAPSSEANDDDYGDTYEDLDAYQATKIGEQPGATETPAVALFTGDNEEDGEPIEEEIYEDVPNANEPPPAPLPERIPKPSAANKPLPPDPPRSGSPPPVPTTHRPMPAAPDTQTAKPYSPHTQIKSYQGKNVKNIKTGSGPAHAKPAITSTPGPPIPSRSAPEMITALPRKEPWEEDYANIYIGLWDCMADDQDELEFRRGEMVHIISKEYDPFSWWIGEKNNKVGLVPKDYLMKAYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5L3</accession>
    <name>A0A913Z5L3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046070.1">
        <property type="nucleotide sequence ID" value="XM_038190142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5L3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190142.1">
        <property type="protein sequence ID" value="XP_038046070.1"/>
        <property type="gene ID" value="LOC119720467"/>
    </dbReference>
    <dbReference type="GeneID" id="119720467"/>
    <dbReference type="CTD" id="9440"/>
    <dbReference type="OMA" id="HMSYEPQ"/>
    <dbReference type="OrthoDB" id="10058398at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74121" checksum="CED105F50DF0E8C0" modified="2023-02-22" version="1">MDSVTVSIESLQEFQVQEVSLDGQETYTKPLSMSESLAKLAHKIDFTKPEGEEIDGALADEDKDTKKADVKEESPAVQAVQWPWESVHSKLRCALTEISVLSDILHICRWAKDPRYMVLDPVSQEPTQSKQIIQLLDKKKSLGVAASVLKSGANRMMRQPLNATTASPQKSQHQNDFHADLLRLRQHWRLKKVGSNILGDLSFRTAGSRFWHNGTFEVTKITDVDCDATEKKNVTPLKVTIPSDIEGTSHIQVLIQEGEAEIATASLSQPSRSRVSADAHWQERLEAAQTVLFCKEVFAQIAREAVQLRSPVPHIVVGNQIFCTLFPGVRLCLALCHNTSMDSQVGTQSYRTGLKCRYHLGYQSTSSFDFRLGIEPLRQPNHSHALEHSLHQLLRELHRSNLSGTTPRPITASLTVSKKRRLAGPQAISRKELTDSQQGECLLEKVLKQAKHIVLRKRVADVINQLSSDLQDPVILVHWSAHTQPLVSTAKIHISTSGYEQMAMILLQLTVEVDQIRVLCKDGRVIHANYEQQQLKDLLRCQISQHQIACVFSLSKSMNMHVLHYNLHLGVGSASKLGNASSVLISTHHGQRTLAVRSDPLNGIRVQVKGCKNPHDTEQKSNVVTDPKWETIMTDYREVDMDRIPGRTFVNKMELLMAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5M3</accession>
    <name>A0A913Z5M3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BAR homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046080.1">
        <property type="nucleotide sequence ID" value="XM_038190152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5M3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190152.1">
        <property type="protein sequence ID" value="XP_038046080.1"/>
        <property type="gene ID" value="LOC119720479"/>
    </dbReference>
    <dbReference type="GeneID" id="119720479"/>
    <dbReference type="OMA" id="RMFAPPF"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000097">
        <property type="entry name" value="barH-like 2 homeobox protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="399" mass="44714" checksum="71215068F506BAD1" modified="2023-02-22" version="1">MEAVPLPSLRSPLTLASSSPRSDTSSSSLSSSSSMMSSPSSLLPTTIKANSPQDMDESVHTASGAAGTRSTGFQHHHHHHHHQHPHEASIVLSVPRAATAAVLDSKSTVEPSGSSPPHTLPNNNTIHPLKTYHMEPVRTSNAPSFLIRDILGDMKPREARRGVASEEEEADEEEIDEDRDSECDERTMYGEHREKLSVRGSDSESHRYHHHHHHNTENNLKRPHSEDISEEMKNGHCDMGTGKDNEISSSRDSHSPGKPKKPRKARTAFTDHQLNSLERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYTASMQRMFAPPFYYHPTQGIVSNLDGLYNLHAGQRPVFPRLFLHGLQQHVSHLPLAPRALHPHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5T8</accession>
    <name>A0A913Z5T8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 32">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038046160.1">
        <property type="nucleotide sequence ID" value="XM_038190232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5T8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190232.1">
        <property type="protein sequence ID" value="XP_038046160.1"/>
        <property type="gene ID" value="LOC119720531"/>
    </dbReference>
    <dbReference type="GeneID" id="119720531"/>
    <dbReference type="OMA" id="YVQILKX"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05053">
        <property type="entry name" value="PTKc_FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000007">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000011">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016248">
        <property type="entry name" value="FGF_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000628">
        <property type="entry name" value="FGFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 26" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037585797" description="receptor protein-tyrosine kinase" evidence="26">
        <location>
            <begin position="32"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="359"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="610"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="616"/>
            <end position="622"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 24">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="692"/>
            <end position="694"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="379"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000628-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="931" mass="105308" checksum="44DA2718CCC5B5BC" modified="2023-02-22" version="1">MDSRGRYSLRRSIHSLLILCLFSLRLTLAEAAVTSAQDIVPSRSSPRNLRLTPTKLTTVTLKWDAPLNGGVYNYDVNYWRGQDQSQVRTKNVSNSTSCDVGDLQIRVNYTFSVSISGSPELVTNEVTGSGISPRPPTINKDGRMITELKKVETENAKFRCSVDAYPKPNITWWRGNVRLETGDDREVKRATMTINDVVVEDSGVYSCYVTNDYGELRVNFTLEVDPDDSEVYFSSNSESSYGAIESTVSDLEPMAPEFNKDKYRFHDNMLKVAGERLTLKCPYRANPRPTVVWTKNDKLNWEQQSNFRDRVTINDFKLIIERLMPSVDQAKYTCIVTNELGSIEHTTIIDITERIATRPIISQIDDQEVVVGSNVSFECKIVSDATPHIVWLKMEKPGNVSQLQTMTDRLDLIVEKWTQELSKSCSEVMMEYLSNFTQHWQCISNDEHTSQNLKVQTQTLKIYNVSFKDSGLYTCLAGNYLGITRASATLSVIAVTTHPPPTSAPVVAIVRPGHWDQQKTVMVVAIVCSFIILILFFFIFIMCYKSNQRHTRSPMRVVNKTQLIRQLSTESGHSTAPLVIGRSRLSSSLTVVSEYEVPLDPEWEFPRDRLTLGKALGEGAFGKVVLAEAVGISNKEQTTMVAVKMLKGNATDRELSDLVSELEMMKMIGKHTNIINLLGCSTQDGPLFVIVEYAHHGNLRDFLRLRRPPDNNEMTVMLPDREQLTNKDLISMAYQVARGMEFLASKKAIHRDLAARNVLVTENYIMKIADFGLARDVHYIDFYKKTTDGRLPVKWMAPEALFDRVFTTQSDVWSFGILLWEIITLGGTPYPSVPVEKMFDYLKMGKRLEQPQNCSLEIYHIMRECWHTSPGLRPTFFDLVEDLARIISLASTQDYLDLEALGDAPVTTFVDVEFDSGNSSQHSRHSSESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5W1</accession>
    <name>A0A913Z5W1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046396.1">
        <property type="nucleotide sequence ID" value="XM_038190468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5W1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190468.1">
        <property type="protein sequence ID" value="XP_038046396.1"/>
        <property type="gene ID" value="LOC119720675"/>
    </dbReference>
    <dbReference type="GeneID" id="119720675"/>
    <dbReference type="OMA" id="GWHIHVL"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036895411" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="301"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="453"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="618"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1022" mass="109307" checksum="70DC2DF00C251518" modified="2023-02-22" version="1">MEYLVKSCIVWMGIVLVAVAAQDPTYVATFSMAGASGNATFTRGTGSNTIIRLSMSLPAGTYNWTVREKPTVYDQRPVCSEVFTGGVLANGGDLTTAHGKLTGGTSVTAEFDNDQLKLTGTDSISSRSLVLEETTSGTLICANILDYDVDVVTAVAKFVSPFAGTVTFRQRQGEPSALTTVLVDLYSVLDPQVATYSWGIHSIQDYNKDMNLQQRCSSTMSAIFNPIGDLSSKFGDVTINPASSSRTRYFIDTNLPLDQSANSVLGKNLVFKNSDGTFIACSPIQELLPKAVSAEISVSGVNGTLEFRQRSPYDPTHISVNLAKLRGLAAGYHVHVQPVTGRINTDDQPASNANVGGHYNPFGVIAGDSPAAGTGTHDQYEVGDISGKFGSLSSLDAFSGQFVDWNMQLFGKYSIVGRSIVIHKAEANARWAYGNIGYPTDVVTVKADFSSVVAGKMVFRQDPNDPYSDTTVYVEVTRADGSDPTVNHNFHVHEKPIGNDYLSSSSRCASAAGHFNPFVDFKNGYDLCDFTNPYRCEVGDLSQKLATIDISSSISSSSSKYFFTDPLLPLTGYYSVAGRSVVIHMPDRAAPRLACADLYDAPSISIQTDAWDGGPAIRGPIAISQASEFDRAKVSIELSQLDQLAGGWHIHVLPIDPDNVDAPCSAASVQGHYNPFGADGGQDAPATGTHDMYEVGDLSGKFGSFASLDSITAVYMDTNLDLTGPRSVGGRSLVIHRDDAAGSRMVCSDLDQSVADGDFSIMAQATFQGDAVTGTITLKQIRFASGYQGDTIVQVDLTANDDNIEYVLEIPKTTCDDDDIFNPYQISVPTDQCSVSRMRLCSVGDLRSKHGMVYSNQRVFMTDINLPLYGLNSVIGRNLRISTSTADGGKSCSTIIPDGASGRKINHVYPATTAFDAYGFQTTVANAIASGNRWQVVPSQEPGESTEFPGCSSVDFWVIGPNVENLVTAFSEAVKAGSLDSYNPTDQCSEGSGVSHVIPSGFMILLSTILGLFVIVPLQRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z654</accession>
    <name>A0A913Z654_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047202.1">
        <property type="nucleotide sequence ID" value="XM_038191274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z654"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191274.1">
        <property type="protein sequence ID" value="XP_038047202.1"/>
        <property type="gene ID" value="LOC119721250"/>
    </dbReference>
    <dbReference type="GeneID" id="119721250"/>
    <dbReference type="OMA" id="CETISIQ"/>
    <dbReference type="OrthoDB" id="6051775at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663820" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="185" mass="20431" checksum="3F585E3A2D3ED97D" modified="2023-02-22" version="1">MAKNVHLRILHAAVLILFVVGVSGLCPPDWFEHGTSCYKTDHVKRTWDDAAAQCDRLGGELLVIETIEENEFIHGLLKNQSKEWAWLGCSDRSTEGQWLCYKEAASGVTFRNWSPNEPNNRGGTDDCMAFHMVDGKWSDSKCDARIVYAVCETISIQGKGEGVTPSSSAAPVSCYTFGSNGRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6Y7</accession>
    <name>A0A913Z6Y7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047487.1">
        <property type="nucleotide sequence ID" value="XM_038191559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6Y7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191559.1">
        <property type="protein sequence ID" value="XP_038047487.1"/>
        <property type="gene ID" value="LOC119721478"/>
    </dbReference>
    <dbReference type="GeneID" id="119721478"/>
    <dbReference type="OrthoDB" id="6781885at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47878" checksum="FAFF3C12367A4F27" modified="2023-02-22" version="1">MQQDINLDILDEARKSLFQFAITKHTERIQHGDVQNSTQGSRVVPVPEKESSVREEIVSEQSSVNYSTQGLQYSYNELVEGSIPPIKTKGIKCGHLNIHSLVSKIDELRLLLKHRPFDVICLNETLCDSSISDEELLITSPTRVTSHSNTLIDLIFVNNPDVFTDNGVFCTSISDHFLTYSVRCFNFKSSTQQGHNYIEYRPFKKMIVQDFIHDLENVPWNAIVNITDIELAWQTWLNSFMEIVNLHAPLCKKKIRQNACPWITDDIVKLMKERDQIHKAAVKHNCQNLWNEYRCLRNKVTHMMQKQKTDHYCGLIRDNAGNSKKIWSCLKEVTPKQGRILPSSIEVNGSDCSDSDQIANAFNDYFVTCAQNVTKDLPVTTPTVFTDVSGGKILERAVCDQLYASDRDTNFVYRGVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7B0</accession>
    <name>A0A913Z7B0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047579.1">
        <property type="nucleotide sequence ID" value="XM_038191651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7B0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191651.1">
        <property type="protein sequence ID" value="XP_038047579.1"/>
        <property type="gene ID" value="LOC119721572"/>
    </dbReference>
    <dbReference type="GeneID" id="119721572"/>
    <dbReference type="OrthoDB" id="6112830at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="31231" checksum="403EC710BF19FD22" modified="2023-02-22" version="1">MNAISVDKSHVCHKCDKSFGRRYNLRRHIENVHAEEEVKVEDVDVENSEPDFKKRRFEDSEIENCRTESTQDEDEDFDEEYSESETEVKDDNSSDEEESFEDSEIENREAESSENEDEVFEEGYSESETEVEEDELSDEDESSSDLEDNAAYQDWLEDAKDATEEMWSEKYEKYVNGCMDEDQAKEKANRKTLWAVKRCFFNNYKDFLSSYLHLKDNDTHQEIVEELERKINKGTEVNTALNRIMPKHQAKFDGLFRDLEEDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7E1</accession>
    <name>A0A913Z7E1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cation exchanger C521.04c</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047642.1">
        <property type="nucleotide sequence ID" value="XM_038191714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191714.1">
        <property type="protein sequence ID" value="XP_038047642.1"/>
        <property type="gene ID" value="LOC119721745"/>
    </dbReference>
    <dbReference type="GeneID" id="119721745"/>
    <dbReference type="OMA" id="VHGINIF"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="13">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="416"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="641"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="88603" checksum="37C6812CBD251ADD" modified="2023-02-22" version="1">MKMTDSEAKEKKNVSQTGKLSLEEGESSFQNNEDGPSRGTSPHPLLVVDQLRDRERTLSASGAYSETSEGSGGVRHRKRAKPSEPAEEDFVFLDVVADNEIEAHKMEQNYMFGFKKWKSHVTKRPLDERSEIVKTLYEQPKKVKPFIHSTLSIGNVLYAILIGWWLALVYLLVALLMLITVIGRHHATFCLALAQYFLWPFGKFVKEKTCYELEESQEQVGEEKPLLGKEKPLLGNGISASQDSTASLSLSNSLPAYVKKHSNDYLDTDSSEGTVTLSIVNFRGVRSDSGYWRRPSTYVWLVLGCPILLLVHTIIIVVTGLLVVFIPISKLNIIAVRKVLLLPPEKLRINKTSDFKSDDRTYSLEVIMCSYQAVNVYYYKYTVDGMNVILVNMLIFVVFTIVLGYADTDNVVAHPIVKFVMGLVAIIPLAYYIGMGITSISAQSTNAVGAVLNATFGSIVELILYVSMLLKMKDAKTSSTCYNTLVKSALVGTLLVTMLFIPGISMVVGGIKHSVQHFNMKTASVSSTLLFISIAGMFSPTIYNTVYGVFSCRNCTSTIQNMTTEDGFKCSECSQTFNPESSFYMDKILPIVYICATLQLLAYVVGLIFTLKTHSHILQEQMHLPAGSQEHAMMHWGRIKSTVILLCAVVMMSLCAEVVVQNIEPVLKSTTLPDVFFGVTLLAIVPDIPELINGVQFALKNNVNLSIEIGSSVAVQVTLLQVPILILADAIYPLHFYMIFSDVHMWSVIISAIIMNYIFIDGKSNYFQGSMLCIVYFMLLSLYFFAIDNDYSGCIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7G0</accession>
    <name>A0A913Z7G0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047738.1">
        <property type="nucleotide sequence ID" value="XM_038191810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7G0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191810.1">
        <property type="protein sequence ID" value="XP_038047738.1"/>
        <property type="gene ID" value="LOC119721875"/>
    </dbReference>
    <dbReference type="GeneID" id="119721875"/>
    <dbReference type="OMA" id="FKMTELH"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="282"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="10">
        <location>
            <begin position="549"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="741"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="743"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="886" mass="97993" checksum="663B68BD16F4A9FB" modified="2023-02-22" version="1">MPGIDFLRLQDAKENSPQARSMLGLFEEDTSLFTGYVNGLLAACRRVVDCETALSVAIQTLSQKLQEYETLNFPLGRDDSILASTLKQFAQTMEEVSSVYTAHSTQLNDLMVQPLSSFTNGDLSEITNMKALQRMIEQEHDNAIVKYCRVSKKKENETKARIDANDELYSCRKKLLQNSLNYYNSLNLLQYKRTTNLLQPMLGFFQAQLMLFRLGKETLTRQTEEYLGNITESVQSVHSEMGQLSQRSSDKMQEITENSTYYYMPEPTPDMQMQSRPVNTGLSQIAGYLMIRSKSGLTHRWDRQYFFTQGGNLMSNAKGQIAGSLVLDLDGCTVNAAEVDDRRFIFQITRPEDTKKLVTLQCMSESDRAEWITTIRNISSGFYMPENKHQGNIPQAQGVGDARSRAFSAPPTAGTTHGGGGGGEGIITTPTGGTRPKQPMSLSNVPQKQRADSFQHSGKESSRSSDTSCSSSQDIPATPPPSPLDSVLSTTPIQFDMISPSEEQPPPMTRYAPPTREGSQRRINPFGDKEPRPIQIVGSTDPVGYVQMYSLRFLGSMEVRRDKGLDIVMDTIRKIMAARAIHNIFKMTELNLVVTSQSIRLLDSAKQVIKAHHDLTDVSFWAAHQENKRLFAFITRQQGARQQSQFICHVFEADVGAEEICQAISLAADIAFQALLQQRTTALAVGQDKGDSPNLGLASSSPPTSQFNQPPFHTKELNQTLSQQPGHQTLQPSEAHLQLGQAQMQPSPVQLQPSQTQLLPSQTHLQPSQTQLLPSQVQLQPSQTQFEPSQTQFQHNPQIHHSQPPAHPSQPSGFIPVHTMPSVDPHSNQHFAGPANNSNSNKNNSTYAGSAYVPQVPIASGLEGLNLGKGVEGGYDNSKALDESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB04</accession>
    <name>A0A913ZB04_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048962.1">
        <property type="nucleotide sequence ID" value="XM_038193034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZB04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193034.1">
        <property type="protein sequence ID" value="XP_038048962.1"/>
        <property type="gene ID" value="LOC119722735"/>
    </dbReference>
    <dbReference type="GeneID" id="119722735"/>
    <dbReference type="OrthoDB" id="10180059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037390526" evidence="1">
        <location>
            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="24160" checksum="3CEB8515A3107EEA" modified="2023-02-22" version="1">MGLCWTCLTFATIMYAICGSARSKMKTLHFGPVSPSAPGEEFDKRLWLKSAMPRGQDRCPKMDDHQSVSQDHMTTESIQAACAVITTDSSATPYPEQGQFSSSLERLEFTLQSAGNIRVDLYGANNQHLFSLELRRFSSTIYRRYGEWDSDYVGTGIEWANGRFWISSSTSKLQVGGDGSDDPMISFDHSSGSHDIRKIGLYSDEYADWTIFTPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBE6</accession>
    <name>A0A913ZBE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048894.1">
        <property type="nucleotide sequence ID" value="XM_038192966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192966.1">
        <property type="protein sequence ID" value="XP_038048894.1"/>
        <property type="gene ID" value="LOC119722711"/>
    </dbReference>
    <dbReference type="GeneID" id="119722711"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="50871" checksum="17636A26C8DB68EC" modified="2023-02-22" version="1">MWLYHENVTVYAQATASLAQLDILVCTFFTCVFQNNSDNCSVAYSFPQMDHPLIWDETGQSPWAPMNESFDVPSNERYKLFNHSLQILGFENLAEADKYVYSNAETVMYGFVLPVLELLGILSILSFFFTLCRVPSMWNVTNFYLSNLAVADLMVLISEATHQQCVALPTQSILDVSYLGNSAQAVLTLLAYTGSVGVISSIAFVTLLSYDRYFAICYPFQHRNLNLKRRSIRAAVCIWVLSFSMNLIVFFNRFLAFNVPPIKCLVWPTEEKYKHLSGNVWVYGNNDATLLTLNMVFTYLYFCVFLLSLILTVTLNILLIKGLHASNPTGDQIRGPSKHLRRVTLIIGINTAVVFVCFLPQAIYCLIAILVGSRKEVNVSDDVEWGLNLMTACLKLMNSSINSVLFNASSGRYRKAFKQAFCCRKRQQVPTNNIPLQTLPRTNPADRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDC1</accession>
    <name>A0A913ZDC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049509.1">
        <property type="nucleotide sequence ID" value="XM_038193581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193581.1">
        <property type="protein sequence ID" value="XP_038049509.1"/>
        <property type="gene ID" value="LOC119723060"/>
    </dbReference>
    <dbReference type="GeneID" id="119723060"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="464" mass="51735" checksum="A1156D8FA731DCB0" modified="2023-02-22" version="1">MLDAWWKKQDNPADAPEKLRDALQAVDRADLASQVPGTAGATFDVDQCARELAAHYRETMKVTTHPKEKHMAREMDDMYVNLQLLEETNIPSPVSSSETETQAETVSQSEHLKASKRAIDVNRMGKKFDIIDAIFSQILTDSKLKKRDLEQYIHDNPERVLILLDGADEISLQRVKDAQCKNGFDLNGVLSFKSLKSCKFFMDVYGWRGALMLIGSILLHLAVCGALLRTHPVTNQRDGDYAIVTNTSSDDKTIRDKFRILSVLTSMKNAVNIDLFALSGYWLVVLISIFTTVAATAWFVYFTAHTNQYKGFSLSEVVAFVSVFGVGKILGNLAVAFIGGYQFIGMNLLMGLAVTVSSACFLTDLLLESYWPIMAYVFVYGFFQSFIYTLLDVMTKETVGVERLGSALGWIGLKCGFVRALFLFLPGLIYDTLGSYTVAFILMAFLNALALPVLLVLMKLQRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDY5</accession>
    <name>A0A913ZDY5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Suppressor of cytokine signaling 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Substrate-recognition component of the ECS(SOCS7) complex, composed of SOCS7, CUL5, ELOB, ELOC and RNF7/RBX2. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6. Interacts with phosphorylated IRS4 and PIK3R1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049699.1">
        <property type="nucleotide sequence ID" value="XM_038193771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193771.1">
        <property type="protein sequence ID" value="XP_038049699.1"/>
        <property type="gene ID" value="LOC119723209"/>
    </dbReference>
    <dbReference type="GeneID" id="119723209"/>
    <dbReference type="OMA" id="ISEYGWY"/>
    <dbReference type="OrthoDB" id="5979828at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10388">
        <property type="entry name" value="SH2_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03741">
        <property type="entry name" value="SOCS_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000029">
        <property type="entry name" value="Suppressor of cytokine signaling 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035866">
        <property type="entry name" value="SOCS7_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037346">
        <property type="entry name" value="SOCS7_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF5">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="8" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="863"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="19">
        <location>
            <begin position="966"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="641"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111892" checksum="15A55AE970F1800B" modified="2023-02-22" version="1">MGKSALRLTMLSSKQTQKTQRDMAPDPVSIFTKMRKSLAGKHYHRNNGGFGNGTQTRSKSMTIPQMDRDTAIPYIRNSSVDKARRSSYSSSLAANEEHVKAGLAGVSNGSVHMNGQVMNGTYAAMDENANDAAKSDSHTEPKRPEVSVFEKQGARPKVRKTSTADDSTKAFDKSASGGKVGLEQGMCHSACSGSPKEPPCVEMAQPHFPAVEINCVSCSASRRVSSEASSGGGKAVMQVPLQEPTPAGDPSELAITPGSQSSVLSNSDPALSMSEAPEMENPGCRTEIPKPNPAAESQLKSDEEDEEIKPSFSEPEQINVEGQIPTNPAASCLSCPTCDEAKVSQTSGITALSASCVSPGEQSSTDLKYSRVPDVGQEELPMEHGTLLTSTEGSGQRSPSSNANQTESLLISESVSEVEKSVESINKLDPLDESKTGSSKILKGDLISESRSAVDQAMMDNIMDLVPAAVVESTSKPTGDTESCKTEGSRHCCTCTCNKPLVHPAPPSSKRDNAVKATLTLEDIPKDIPGSSGDSPKLPRTPHIAMLVNSDELFADADRKSKSLSEQDLRMLQTLNDFSIHQEATQKKRAFKKPSQANYSETSPVLGAVNASQESTSISQEYPPGLERHDDIFEDPAIVLGATGGSDDIPRRKAPRVDRSSKPKELCEAAKGATAEEPPPLPPRLPAAKKNDPFAAYPIFDDEDDDFPTHEFLHEINMDIYTDPNTTIKSRSLPRDTTPSQRASPPELRASPPELRAAKRGKTVNMRNRFSQIFKPGSKKKRHSTHGFPDRPLPDIPLNPRLPRSSGNARQTNSVLFGTSTGDIVSQQAVKEGLLRETPTKEEVDRAREQFAVSLRRISEYGWYWGPMSWDDAESRLENMPDGSFLVRDSSDDRHLLSLSFRAQGSTHHTRVEHHNGKFSFWSQPCSHGSASIVEFVEEAMRHSHSGRVLYFLRPRMPGYPPAAVQLLYPISRFQKSRSLQHMCRFVIRKHVRLDHIDNLPLPRRLKDYLKEAQYYTQEDILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZER0</accession>
    <name>A0A913ZER0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-box protein 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="16">2.3.2.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Sensitive to apoptosis gene protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes) composed of CUL5, Elongin BC (ELOB and ELOC), RNF7/RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B; additional evidence is however required to confirm this result in vivo. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2. May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="2.3.2.32" evidence="16"/>
    <dbReference type="RefSeq" id="XP_038049959.1">
        <property type="nucleotide sequence ID" value="XM_038194031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZER0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194031.1">
        <property type="protein sequence ID" value="XP_038049959.1"/>
        <property type="gene ID" value="LOC119723412"/>
    </dbReference>
    <dbReference type="GeneID" id="119723412"/>
    <dbReference type="CTD" id="9616"/>
    <dbReference type="OMA" id="RQNNRCP"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031466">
        <property type="term" value="C:Cul5-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061663">
        <property type="term" value="F:NEDD8 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16466">
        <property type="entry name" value="RING-H2_RBX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000156">
        <property type="entry name" value="RING-box protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="118" mass="13593" checksum="4C6BBA6A5780F3E3" modified="2023-02-22" version="1">MSDSQVIMKDETCSTANGKSGSMESTKQDAEVKPFTLKKWNIVAMWSWDVDCDTCAICRVQVMDACLRCQTENKQEECVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQEWMVQRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF96</accession>
    <name>A0A913ZF96_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049726.1">
        <property type="nucleotide sequence ID" value="XM_038193798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF96"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193798.1">
        <property type="protein sequence ID" value="XP_038049726.1"/>
        <property type="gene ID" value="LOC119723234"/>
    </dbReference>
    <dbReference type="GeneID" id="119723234"/>
    <dbReference type="OMA" id="GTSDWFH"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203027" evidence="4">
        <location>
            <begin position="37"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="205" mass="22194" checksum="12C090B6D8CAFD20" modified="2023-02-22" version="1">MTFPRRASRALQQKQQHRLVTVLVVLGALLNTRVHGQNTCPRTYYVQESTSALQRAICEPPCVHGQLCVSPNVCQCPAGYAGNNCAEPICSPSCRNGGQCVSPNVCECPHGYGGKSCSQGIVSAVYNKAGDQCLRGHVIKTVSGPSRMRCVAACMRNTRCKSVNYYSTEQLCELNGVTADEAGTSDWFHDADCAYYQSSQNPSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGH7</accession>
    <name>A0A913ZGH7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050897.1">
        <property type="nucleotide sequence ID" value="XM_038194969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194969.1">
        <property type="protein sequence ID" value="XP_038050897.1"/>
        <property type="gene ID" value="LOC119724047"/>
    </dbReference>
    <dbReference type="GeneID" id="119724047"/>
    <dbReference type="OrthoDB" id="10019607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7276"/>
            <end position="7298"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="10">
        <location>
            <begin position="42"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="6954"/>
            <end position="7046"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="7187"/>
            <end position="7232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="7234"/>
            <end position="7268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1227"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3597"/>
            <end position="3630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="5627"/>
            <end position="5650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="6595"/>
            <end position="6616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7100"/>
            <end position="7130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7333"/>
            <end position="7523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="5638"/>
            <end position="5650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7112"/>
            <end position="7123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7345"/>
            <end position="7356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7361"/>
            <end position="7370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7434"/>
            <end position="7446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7457"/>
            <end position="7470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7499"/>
            <end position="7509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7510"/>
            <end position="7523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="7222"/>
            <end position="7231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="7523" mass="830136" checksum="BC80D33ACAE1891D" modified="2023-02-22" version="1">[encoded data, 7523 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH00</accession>
    <name>A0A913ZH00_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MSL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Male-specific lethal-2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the MSL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038050295.1">
        <property type="nucleotide sequence ID" value="XM_038194367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194367.1">
        <property type="protein sequence ID" value="XP_038050295.1"/>
        <property type="gene ID" value="LOC119723622"/>
    </dbReference>
    <dbReference type="GeneID" id="119723622"/>
    <dbReference type="CTD" id="55167"/>
    <dbReference type="OMA" id="QEGMAIN"/>
    <dbReference type="OrthoDB" id="10012174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13122">
        <property type="entry name" value="MSL2_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16522">
        <property type="entry name" value="RING-HC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000174">
        <property type="entry name" value="E3 ubiquitin-protein ligase MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032049">
        <property type="entry name" value="Msl2-CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16682">
        <property type="entry name" value="MSL2-CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52051">
        <property type="entry name" value="CXC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 18" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXC MSL2-type" evidence="20">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="407" mass="44572" checksum="09EDF086537A80FA" modified="2023-02-22" version="1">MEFVLRWNREFVLAKKAVWRTDSGVDLVAGESKMNATTLYVSTCRYILQAEHNDPNTWSDLYRRLPYLRQSLSCCVCAGLLKDPMGPSNSTCQHFVCRGCLGGKMLLKPSCSWCKDYSMFAEVKQLQILLSCYKKLCEYIADTPIARNLVGANGGTSNHSSGLSILQEGMAINDSHYERSRSQDISGFNIVEYLAKASMNSSSGAGGKSVQNGHDGHASGAVTPHHGHPEVSRNAQGVLNHTEALNGSEAEPYVSIDGSVDEYSVTITPNSDNSASPKIKIKRNKRLELGHHSQPKSNLHGLSIAKVKRKYQRRSKNLLLASNGLVDLHSLSNTPRKLVISGHRAKLLKAGRKLEIKEGCRCGTGSKYPGLNTCQGHRCPCFVSEVPCTKCRCKGCRNPLKSSEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHE8</accession>
    <name>A0A913ZHE8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 126A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051213.1">
        <property type="nucleotide sequence ID" value="XM_038195285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195285.1">
        <property type="protein sequence ID" value="XP_038051213.1"/>
        <property type="gene ID" value="LOC119724297"/>
    </dbReference>
    <dbReference type="GeneID" id="119724297"/>
    <dbReference type="OMA" id="GDLHCET"/>
    <dbReference type="OrthoDB" id="6234762at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009801">
        <property type="entry name" value="TMEM126"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 126A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16296">
        <property type="entry name" value="UNCHARACTERIZED HYPOTHALAMUS PROTEIN HT007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07114">
        <property type="entry name" value="TMEM126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24788" checksum="A7FCE8A049E671FE" modified="2023-02-22" version="1">MAISRKDVVSVVTEQSSTQSKEQVGTGEYLSASEALEKQLQLVKKLPDSKSWPFGYGPLVLSINAGLVGVIGNSFFRRMLMVRRGLFLTSIPSTLMPALLIAPAYMKFVTHPILLNDLDCAVCAEIRGGLINFLLGAMYPVLLAAPLNAALARRYDTVKVPSMSFKNFDRSHFVKFWRSKIRYFKGQFVTIAIFQTIFGMFIAGSQMRVAKEDLGQKLVKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHK9</accession>
    <name>A0A913ZHK9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050879.1">
        <property type="nucleotide sequence ID" value="XM_038194951.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194951.1">
        <property type="protein sequence ID" value="XP_038050879.1"/>
        <property type="gene ID" value="LOC119724031"/>
    </dbReference>
    <dbReference type="GeneID" id="119724031"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="3258"/>
            <end position="3346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2191"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2760"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2196"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2777"/>
            <end position="2786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3346" mass="366685" checksum="2543403A262F98A6" modified="2023-02-22" version="1">MEVLVLGLSTAATVTEASTLRVVIVSCTSITHCLEVYCSTSSDQRCDRCDGDYGSSLGSAYKKSGDMRQCIKQCSWRSDSNACYPGSCTNWRCTCSSGFSEDDCRTMGISQAPVLSEHRATLVMGATTLESPTVLNSTDTVYTNGANFTNITIQWVSSYQPTGLPSLSSGGHPYIHSVRMGVVDAGVTAVVNRVQGETYSIGSWQCIPTSGPSFNQDQPKTDLVHCEYTFTLDLNVWTPTTGDILRCNVSSTSGGYMKLYNRDSDSRIITRYYSGSTSYGSPSFTFDFVQPYHCVDGSGCRDTMLDTENVVLQATIDVTWDGWSDSVAGIKDYRLEVRQLSGSHGDEMTEIFDSDPIFSGVTNSGQNVTLPHVGVYSVVLGVYDNAGNVKHSRRFVFFDDNESDVTFTQRNASVRVLSATAETDYVWLTHLDSLAGTTSVHLDWTNRFINVDHLNQGLLKPVGSYVPATIHPDYDQNFGLRGRAAIPNAFGVTEFRVLYDIDHSGGRTTVNVSDDNSDHWSSEGVTTQATYDVTLVDGDSIRFWVEARDLAGHFLRDSVLVHADASPPVIEDFWLVRDGEVNVAVHNSEDLHEMSIAFRAYDIHSGVRTIELRLFDNHTGGEMELDHQTVPARKINTNDEDCDPVSCMCVPTGDCYAVDYDFHPKQFSTTHDYDYFIKLTISNHAKLDTTQTIKVTIDTSAPQAGVVHDGLRGSNEVDFQEGNDLSAHWEGFFDKESGVKFYQYLFDKFCWMNETSIGSVSDYMMRTTSTYVSWTAPSPGPYYVTVIAFNRAMEPSEAVCSDGVVVDTSPPKLTQIAISFVRMWPRLAKDVEGRAWFINEHRMKMELINASSDCSSKAALVEDLSVYPEMSATNDTTENPQGDLDCKWIRDVQQQFFIPTDKHLSMSWTGEDAESSIYDYEIGLSTDPSNLTPDLVTFRSTAGRDHFIMYHPDISHGSVFYLVLKAVNKAQLSTFKKIGPIVVDTTPPVFVGRVSVHAEDEYLIAEWGESGFIDDEDTSLRYQVAIGSSPGGTETVAFETEKDYRIGPCLSRSHCAAFSLDDLNWHLHGDHEYYVTVQAQNGAGLTTAGTSSVYRHMVQLPSVGVVLDVAPPGEESDVNFGVAKDIDVQTDNTSISARWFGFEHPHLDINYEIAIGLEGGATEVSGGFIDVANATFYRLHGQDLAPLETYYVTVRANSEAGSVNVTSDGVKVIQEGQALEGAVIKDGLGCDQDATSAPSGYSHHSAAADQPCEDDITYQSSTSDIAARWTIPEMLQPFVTNVVWAVEQEIEIYQDDENTTKEWIRVLDDHDVGMAFQHVGAGIGLHGGAHYRSKVQFCHGSVCFRPIVTDGFWVLSQPPEVGQITVNSTETTQGRTNLHVVLQPFAHDYVRYDDPQELMDFYEWSIAEDGSDEALLSPWIKIQNLVFTGDAARFTASYPGLLDLDSCLQLSVRGYNKAGLFSIASTEIVDCDDATLIVPHMVIDADHEVRIEQNSLWPEPDKNYISSTSSLSAVWPTLRHRAYIWAVIEDIGSNALGNLDNGLHYPCDHPMKKDCGETDKEFVNVPDLVLVHGKRYRICIHADEVTLEHEFWNEPLPAVSSCSDGVVIDTTPPTPGSVWIGWDRHQTYQTSSSELVLHWDSFTDIEEHGMARHHSGIKYYECAIGSMPGGRDVMGFTRVGITNSVLIHNLRLQNGHQYYATVQATDFVGLSSQAMSDSIIIDTSPPIVSADYMLDIGGSFIRSTTSISASWENVFSDKDSGVSYYEWAVGSHPGHADIMPFTRESTENGVSDPSRPLFLLEGHSYFVSVKAINRVGLISMKSYGAFTVDASSPLAGQVLDGNPALVLANHRDRDFQEDRRMIGASWEGFHDPHGAIVGYFWRAGTCPGCSDVVPEQHVGMDTGVLAESLNLVPGLTYYVTVTACNAANLCTSVSSDGVIVDDSPPVPGRVYDGGPGGGDISYQSSRLQLRAHWWGFHDPHSGLSHYEWHAGTTPGAEDILPSTRIELSGDALIFLSDSDQLPIGADIYITVRAYNRLGLWSQATSNGFRVDSSPPDVVDTPAVGEMQEMDVKNTQIMRDVIHCSWKFVDPESGIKNQFISVCTHHNGDVNIPTLEIAGSESDHTFTNLTLHEGSRYIVTVVACNFAGLCIDSQTEPVLVDGSPPSVGTFAVGTESAANLDRHHITWIDPTEFGETTRPNELNTTVIGNTTDSVNSTTETPPTTPFLPPYLSGWMTWIEDPRTSLGSLALAWLGFADVHSGISHYLISVGRTYGGSEVTPNGPIRVNHSNEGMSMDEGIAQTAIVPLEGSIVDLPHPYLYISLWAVNGVGIPSGRHHSTFEVSHTSPDEGALVLLRRCSPTTCEGHCACAPMDRTCNPAQYCTDVTDRNPNTELEVLDVMNLMHDDIDTMIDIDETTTQYTAAAVWHVTEQKGLDIKWFEWSIGDDSSSDPVGVFDPVKERIWFDIGQDNVTIITLDEDHKMLRGIKYHVFIRAWYDANTYAVFRSDGITPSITPPKISTIKGTKIKDLATSDAQKDTDYLTDPNGIYISWDGVFLDEALSHYQVSLSTYPGGEDIRQFADHIFHATGSANTSFTNINFQSGLRYYSNVRAFNKAGLHTLKSSDGFVVDSRMPDPGLVFDGIGLHDVEYQNSSTVISASWHGFVDLESFIDHYEWCVGQTLSPEDDGILPCTDVGIHLSASKGLSVPLANGIRYFSKISAVDAAGLQSVTVSSDGFVVDTTAPEPLEHIHFGDNLIQNPSFENMQKPGNRDSDLTTEEIPSTSSEYFSSSRQDEQLLQWDVWSNSQIALVASGETIAQDGRSFLSLHGSISQTFNTTSGSHYQAVIFASHIVPSHNPLLNQEGRIEAPGLNRVFRLYDRPAHGHSDQSLRSVRWQQHRFYFTASDDVSTLKISSVGQSNGILLDDVQVKRITLGQSTGDGAVEVHTHISQGWSSVQAKWHFIDPESPIVDYSWAIGTTRGGTQLQTFTSVGTQTDAMNSNLRMAHGSRVYVTVIARNAADLITRATSDPVVIDLTPPIIHAVADGRDLNDVDFSADDSALTFSWSASDPESGIDHCTWAVGSGPGLDDILPMSSSPDATSSITASLSQIMVEGQRLYVTVTCHNHAEQSSWKSSDGVTIVTVPPGSTTAAVIVKTMSDTQYESRDGYQSQSHSLKASWVGFMDPFGIHSYECLLSGPNAFTSWTPCGSTSETHLDWSGLSLVNDATYSLSVRAINHAGLISQHITSNFTVESSEPVVGPPSLLRSSWPSNTTVDLAWGGLFSSPSSSLVYEVSLGTIPGGSDVMQWVETMESGMNVSRLVPYTDYHLTLTAINAAGLSQTVNKIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHX4</accession>
    <name>A0A913ZHX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038051383.1">
        <property type="nucleotide sequence ID" value="XM_038195455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195455.1">
        <property type="protein sequence ID" value="XP_038051383.1"/>
        <property type="gene ID" value="LOC119724411"/>
    </dbReference>
    <dbReference type="GeneID" id="119724411"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="252" mass="27829" checksum="665F00BA8501FC08" modified="2023-02-22" version="1">MAAIKGDVRDERSEEGEEEVAPPPEKKGMRVVLLGPPGAGKGVQGPKLAERFCVCHLATGDMLRAVIASGSDLGQEVKKVYDSGALVSDELVVKMIDSKLDTPECSNGFLLDGFPRNVVQAEMLDNLLETRKQQLDAVVEFSIDDSLLIKRICGRLIHRASGRSYHEEFNPPKVPMKDDVTGEPLMKRSDDNEATLVSRLATYHKQTAPLIDYYKKKNILEKVDASHEPNTVFATIQALFTKATSKDKVMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI76</accession>
    <name>A0A913ZI76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051493.1">
        <property type="nucleotide sequence ID" value="XM_038195565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195565.1">
        <property type="protein sequence ID" value="XP_038051493.1"/>
        <property type="gene ID" value="LOC119724485"/>
    </dbReference>
    <dbReference type="GeneID" id="119724485"/>
    <dbReference type="CTD" id="51256"/>
    <dbReference type="OMA" id="VMHTMWL"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000006">
        <property type="entry name" value="TBC1 domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="294" mass="33801" checksum="6CC580A8BBA7C54D" modified="2023-02-22" version="1">MTDGRNFRSHYYEKVGFRGVEEKKSLQILLKEDPLDVGKLSMFCLRFPLPAMFRPLVWKIILGIVPPHPTTHDFVMQQRREQFNDLRGALRIMGLVDESTPLSSEFLKMFLLEERRLPLEDDQLNIECLEEECFVSLAENVIDIFDDEVDAYWIAVKIRRNMIEKDSILQLSQRFVTQLQKDDPQLMQHLESTGTLSRMGPVYKAWFGGMYAGAIPSGPLGRVWDRLLGGAVYITAYVAHVFVVTYRRQLLGMTKFDAILKFLLKVPPDSAEVLVNDAIDRWESSGNQTKPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIK2</accession>
    <name>A0A913ZIK2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038051623.1">
        <property type="nucleotide sequence ID" value="XM_038195695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195695.1">
        <property type="protein sequence ID" value="XP_038051623.1"/>
        <property type="gene ID" value="LOC119724586"/>
    </dbReference>
    <dbReference type="GeneID" id="119724586"/>
    <dbReference type="OMA" id="IRVHIDG"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="42043" checksum="8777711AFF7DCCE7" modified="2023-02-22" version="1">MALSCRKRADPRLGKYRVVYNINMASEPVCVEDFEPYLKASVPDTVWQYFRSGADGEQTLRDNPLAFQRYRLRPRCLRDVSQRDTSTSILGHRLSFPVGVSPTACHASVHRDGEVATAKGVSNAGSAMILSMWSNRSLEDVAASVHPDTPLLLQINLIRNEGRLKAVIRRAEAAGFKALVVTVDQPVVGNKLHLKGGKRDLDPTYPQLLLPGEGTFTLEKALALVKETESLTWKDILRLRGITSLPLVLKGILTAEDAREAVKHGAAGILVSNHGGRQLDGVPATIDVLAEIVDAVRGSNVEVYLDSGVRKGTDVLKALALGARAVFVGRPAIWGLAYDGEKGVEKVLGILKEEFSRAMALCGCSSLSDIKPDLIARMPYNNSDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJK7</accession>
    <name>A0A913ZJK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051255.1">
        <property type="nucleotide sequence ID" value="XM_038195327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195327.1">
        <property type="protein sequence ID" value="XP_038051255.1"/>
        <property type="gene ID" value="LOC119724331"/>
    </dbReference>
    <dbReference type="GeneID" id="119724331"/>
    <dbReference type="OMA" id="NRNSGEF"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35018" checksum="5DCDE4C8684C0B34" modified="2023-02-22" version="1">MGEEHKPTFMENVATNWAAFRLFLWNSEKKEFLGRNGKSWAEIGLFYLIYYIFLAGFWGLMLFIFLQTVSPDHPSYNSYVGRPGLSVTPISEDSLIKYSAANDNDYAKYVDELQAIWDSLDPANQTEGYVDCTNETAPPEGSFCQFDRTTLGEFCIPPDFGYNQRKPCVFIALNRVVDWAPEDYEAGEIPEEVADSYKPGNIAIKCGSYKNKKPEQLGPDTRIYPYYGIPNHYFPFPGNTNVSKRAGYIKPYIAVRFDLAAREEEIKVQCKTYTGNIAPLTGMYDTKYESEIAFSFHLTKEPAHLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNF7</accession>
    <name>A0A913ZNF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052581.1">
        <property type="nucleotide sequence ID" value="XM_038196653.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196653.1">
        <property type="protein sequence ID" value="XP_038052581.1"/>
        <property type="gene ID" value="LOC119725287"/>
    </dbReference>
    <dbReference type="GeneID" id="119725287"/>
    <dbReference type="OMA" id="VECPARN"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000270">
        <property type="entry name" value="Zinc finger protein 512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="928"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1464" mass="163674" checksum="29C6BAB391660809" modified="2023-02-22" version="1">MSSPNYKDASPRKVLQRRVKKQAQCSQQAETAQLPDIETGTCSLHEDGHEISTRNSKTHGGVQQLEDNNDNSQSESSGTDAASASCGQNKKRCLPNEPKESAHKRARLASSQPNETSLAVDGVIESGGSSNGAERESDTCDGEILAEQQPEDVRHDKDMGRGARGSGWGRGRGRGRGRGRGRGRGRGRGRRQGPDIIQTGSDHEIQESNVAPQRRSRGRGRGRRGRTCRVRGGSRQSEHQESDVALQRRSRGRGRGRRGRTCRVRGGSRQSERQESDVAPQRRSRGRGRGRRGRTCRVRGGSRQSGRQKRNRETEEEAMSDDDDDLSKIDDSFEASCLDPADRKSHAIQIALWEKQLQEHRYAKCPLCYCRRRHVMSIFKHFQKCSANRPNSYPCRHCQKEFQSAAGLKYHLLAVHQDMNMEASSSENASDATELSHANISLILRKVGKITCQNEGCSKSFTTVTGYQFHRKICGKEAEEIKCTECDKIYYSKNGLTHHMRTIHRPPPSDEIITPEGVGRSKRRAAERALTSMQELTQDLEQSTAVGQRSKTNKDKDKDWQQTKKKKKDRKVQEDREDEDSSKSSDEEDSNDDNTVSDGDSDSDADRRQGNCTYSDVAADIPDLMKIAHTERMHRFDACKKHASAAEVFKVDWSSWTSLSQSESCQYLPERKRSFRFTSDAKKEPSSLELFQTSSSSPKGTSNRCLNLFVGGPIWSIAWCPHRDDVSTETEYAAISCHRSHNVYHYTTKTYHGPGAVQLWSFDGLHQVNQSQASCQLVCCMAHDYGCIWDMKWCPSGCWQTDSSNVTESASTSRLGLLALACSDGSVRILNVPHAECVQQLKEPGLNPTVLRMQSSVTLRPQHQDLLEECASSCGQCWCVDWAPDNGHTKIAAGFSNGAVALWDLLSQSPLLHVSGSCGVYTLPYCLYDAHHARVTGLSWCPYDADYIATVSSDRFMMLWDVRTPDVALTKVIHAPHTGCKWMNYCNVVAVTYDFKGDQSHRIICHCIRGRGPEIQSWSTSTQQTTDWHIDYSDWLHSLLACSDSGDVTIHILTKFAQFETLRKVDRRKLMKHVYSTQIHQLQPCKKTATPRQKGGTSSTLDIQTDHGHGRHEYSPTTDDQHVADSTNAPNHNHAINTHEDLAFRKQEQREVAHAAAVDSKSLEPEMERVINHDGNEKVACVESGKQEAHETGAESLQDTQSVGTVPNDKCSELDLKLSSLVSTCEEVEQVIQGDGQLVPNSTNLDKNVATQENRLSTGNVSHTMRSEGSRLSSGATQSRHSQVDVATDNEDNMLQSEQQEGLINAAGHKHQDSYQDLESIKNEASKLIRNRETEMIPQENIAVCNKRHSHDAESEFTLRKSTTDEELEDKVYISFTDSVLDEPRKSKWKRRYRPASPASFHKGPLSVAIHKVCFNPNLGTHTWILSGGQTGIVRAHNIKALQSERTIKALRNQTATRSIPTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ63</accession>
    <name>A0A913ZQ63_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053514.1">
        <property type="nucleotide sequence ID" value="XM_038197586.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197586.1">
        <property type="protein sequence ID" value="XP_038053514.1"/>
        <property type="gene ID" value="LOC119725958"/>
    </dbReference>
    <dbReference type="GeneID" id="119725958"/>
    <dbReference type="OMA" id="QLRCTNK"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="191"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1717" mass="190660" checksum="A588D13E47EC3B92" modified="2023-02-22" version="1">MPRKTAQQLDAYIKATAVVYDHSNTKLISRKTKVKPRRKQAFLSVLHYGKTSSDDCCAKRRSSKRRISRQLRCTNKSRSHAGKQKLQIFVRTPLLHTPKTLCFRLDPGTSISSLKERIQTKIGVEARYQRLYFRRNFQLCDLLTLEDNGIEKDENISLRLSFDGLLGGGPKERAQFDQFLWDIATKIESAWKEVAKNLEFEEADIGEIQAKNEDDSKEQGKAMLFTWWSKQKKSREASQKLREALEASGLADLALKVPDLGNRGSDNFATSAAAAADHKTSKQEEQEVTEMIAVEKTLSDRTRMEQETGKPDMSQPETRPVGEFKDPSSKPPSAASLDQLVLGERQIGAQHGQVEQQLVDVTVSTSSERMIDSAELQSCSEEKHMTRTRATPELEQGDDSHIHSPKHLATIPPGQRLHESVEYVRITQPLTTLAVEEMEQNNRHAMSSPEQERLRQETGGPTGHQSQKQQLAGGTNLVSPEQMKHSQVSSSNSESLASSAPQRSTSSVSAVQKYGSNGSKQVSVDLNVGGSYDPIFLAPVTNTTVNFIQNVNVTGKSPEFPKVSIETDVTRQGCKDSGMTDILWTAMTNLCKTHGSDYLLEQVSACLKPYGIELEQVKSGSVTFVVRILSREGLNKLWSMYTTGELARKLTEIILTDELITEDKSDLAIQATVLQSDYEQACRFFDNLERDQQKDEEDSSGMAEVHHTQLNESSTTTSAYSGDPAEHAADRCNEKLKTLFMTTEEEDSSEMTEVQLTQPGESSTATLSSSSDPAELAAVRCKEKMKTLYMTTGTYSQMVKWVDGDTKKILMPKLTLVEAGDETEKMVISYEDIFLQKTPEGDPIKLAVLTGPDDEQKSIILENIAYDWATGSSPTLQNFEIVIVLPTQTIDQESDLQIAVTEKELHLVDLIYAQLLGQDTYIDRGDLKSFIDTNPHKVLVLWDGFDILPYTYSIGNTTKVDTCLELLNRMATKGIRILVTTRPSNIQTFMSKSMDQEPVTHIVFDNPGQAEDLIDRIKSSDVLSDWAKSLNLMPLLCSLSRHSSLPDTMSHLYSRAMTYIFTRQTDMSQDELSRVLIALCKTALEGLVSLQQRFTFQEEEFEDEALEKALDAGLLIRQRVPIGQKFVNDCIQFSHKTMQAFCAAKYCQSLSDEEFQKLLDQIDDPCNIQYLLRFCCGDNKQCCRQILLMLHRKNTKGKEEKELALQCYFESQATHVISEDVIKSWLTGCGSLSISDHTLKSRMWLLQHVADQTQLTGYLAKIHDITFAGCDLSRVAKVVASRLTTMTNLSSLCLDKCRLAGYQFDDILLSLQRAGNLTHLTLSGTGLGGTAKHWAFKLQGLKSLQALSFTSCNLNAEDIPHIASSVGKMPNLANLNLSSNKVLGGNAGTWAASLQTKTHLFRVQPYDSGMQLIIGWLSLTSEDFASILESFSNRRDLVSLKLDGIHGAGGSAGIWTIPLQNLTGIRELGLRNCSLQSTDIKHLAAALGQMPNLAVLNLKGNYDLGGMMTSQTWAASLPLMIHLKKLDMTDCNMGDDHWGMSYNLKYIAKSVSVMGNLVHFDFSGELGEMRVQPCGNGIQLIIKGFSLTGKDMADILQSFSNRRDLVSLIVRDICGSANIWTPPLQNITHLKELRLTHCSLQSTDIEPLAAAVSRMPTVESLSLVGSCSLSGSAKTWAPSLKQIKHVSSLKFGGCALTEEDKKHISEAWGSGVDFRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR13</accession>
    <name>A0A913ZR13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053531.1">
        <property type="nucleotide sequence ID" value="XM_038197603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197603.1">
        <property type="protein sequence ID" value="XP_038053531.1"/>
        <property type="gene ID" value="LOC119725978"/>
    </dbReference>
    <dbReference type="GeneID" id="119725978"/>
    <dbReference type="OMA" id="QMDDVEC"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="207"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="311"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="416"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="520"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="245"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="349"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="441"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="454"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="545"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="88045" checksum="183CC88F08826F58" modified="2023-02-22" version="1">MSPSMDDHKQAGTTEYPRDDLTTDSPTQETPTTAALTSPSMDDHTQAVTTEYSRDDLTTTNSPTQESSTTAALMSPSTDEYTQAGTTEYPRDDLTTDSPSLVRLRDGGSIYEGRVEVYVNGEWGTVCDDLWDLNDANVICRELGFGVALRVASEAKYGPGQGPIQMDNVECTGPESSIFRCSHRGAEDHNCEHSEDAGVECSEPTSVRLRDGGSVYEGRVEVYTDGQWVTVCDHSWDLNEANVVCRQLRFGAAVTVASDATYGPGQGPIQMDDVECTGQESSIFLCSHAWVQRDNCGHSEDAGVECSVPRVRLRDGGSIYEGRVEVYVNGEWGTVCDDLWDLNDANVICRELGFGVALRVASEAKYGPGQGPIQMDNVECTGQESSIFRCSHRGAEDHNCEHSEDAGVECSEPTSVRLRDGGSVYEGRVEVYTDGQWVTVCDHSWDLNEANVVCRQLRFGAAVTAASDAKYGPGQGPIQMDDVECTGQESSIFLCSHAWVQRDNCGHSEDAGVECSVPRVRLRNGGSIYEGRVEIYVNGEWGTVCDDNWGLNDANVICRELGFGVAVTAVPRAAYGYGVGPIQMDDVECTGQESSIFHCSHLGVGNHNCRHSEDAGVECSEPTAIESAAPSTELTETTALVKSLAPVTTRPITRTEAIESAAPSTELTETTAPARSLAPVATLPITKTEAGTDSRTVLIPVLTVVIILIILAVIVAIFFLRHLKGRSQPAGELELVGVINHDYEKCLSIDSRMSYTTCILIFQFHTSILIHYPPQHSNNSFVMLKLAHSDLTLKVPGAPPPLPLGLFFLDSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR43</accession>
    <name>A0A913ZR43_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore membrane glycoprotein 210</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053561.1">
        <property type="nucleotide sequence ID" value="XM_038197633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197633.1">
        <property type="protein sequence ID" value="XP_038053561.1"/>
        <property type="gene ID" value="LOC119726013"/>
    </dbReference>
    <dbReference type="GeneID" id="119726013"/>
    <dbReference type="OMA" id="IVLICYH"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="6">
        <location>
            <begin position="146"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="4">
        <location>
            <begin position="346"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="5">
        <location>
            <begin position="453"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 C-terminal Ig-like" evidence="3">
        <location>
            <begin position="529"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="97126" checksum="AF3C38BA66631877" modified="2023-02-22" version="1">MALMTSDQYPDVSKVQDQFTAYYTVHGAALGFTNLAFTAASKTGLPVSSKVRDIQVFPPLQLSPRNITLMVGAEFQVRSTGGPQPQSQIEYSMGDWQIANIASSGLLRAQSLGHSRVVGKAVGYDPETGSTVVYSQDTIDVYVIRLNGIKIHAPLLRLETNTEMPVYAIGTNEYETPFTFGNVIPGLDFFWTVTNKDVVRVEPVFERQGVSSNAEHNVAMRVHTLNPGEASLKLQAIFNPNMASQARSTKLLIDEIQLQVFERLELISNCHTNLLMTPDTQAPIRTNRDGSARMSYSVLYPDYEPLISVSRQGLVSAGSRTGQTTVLVTAYENFGVNQTLSVLVTVKPVSYMAIHSTSNLLTSRGEKLAVFPVGIGLSFAVAFYDNVGERFQATNTVLEHRLSRFDLLRLQAGSDNGTFVARPAHIGSTIFKVWDKNSPWIEDYVNIPVGSVVQPSRTFVVGDVICFRSPLLTVEGQRGSWRSTSSSVLQLDSSSGIAMATRPGQTTLHHDISTSVATHSEISVVPINKITLEKEAVQFFTTVPREGGYEIPVTLNSELSLKGDNCSSVLPSLGQELPSPPIMCQLGFKDRGVRVQASELFHAFPGFNAQTGRYFCGVTQLQSKHTPSYLATLKADLTLLAIARSVPGQPEVRSEVATFAFHPPAHVHPLHLSLGLAQKDATIIVEGVEATLKALRVSVADTQLIKVSDPYSINANTLHYPVHLVESSQRQFGSVVTTTEVELYDSLTGQRQAIPVGVNLVPLVEQPSPEPQLTGWARVLQVIFSSYPYWILLLIVILAVAGIVLICYHLVLAPRYYTMPPNSGVFLRTPPPGAPPPYLSQSPAYQQSPYQSAFDTSLRHRSTQQQRSPTKLWSTAYSPQEGTSPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRD3</accession>
    <name>A0A913ZRD3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053954.1">
        <property type="nucleotide sequence ID" value="XM_038198026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198026.1">
        <property type="protein sequence ID" value="XP_038053954.1"/>
        <property type="gene ID" value="LOC119726371"/>
    </dbReference>
    <dbReference type="GeneID" id="119726371"/>
    <dbReference type="OMA" id="FRTECKS"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="382" mass="42318" checksum="635435AD6CA113FF" modified="2023-02-22" version="1">MEDHSKAIPTLPHKGVLPTAVSTAAGGDTFTLVVHVIVFLIGVPGNCLILRVYWTKAHKTSTHVFIMALAWADLAVCMQRWHRVSEEAILLAGGHETPRVILIAWAFTNSFIGVSVLMTAVIAADRYDCVCRARNRFFTKKRAQVTVIITFVFSFVINIPAFYLALSTDPSNAVVRMLVFAFQIVLFVTALVMIAVCYQLVYMAIRKHVKVGVHSKAGLSVGGHDGERCCSDVSGTARSGVSWSVEMDVKTSPLKMKGLSTIKGTDACSSSRAIPGTSSDRKAKGEQTRKVKAVNLQRKTTRMLFITSAVFVLTWLPYWTYIAVEYAFLGGAPIHPTFRRMLKSFSFACLFINNVVNPLIYGIANRRFRQDCKEVLKKLRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS77</accession>
    <name>A0A913ZS77_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053941.1">
        <property type="nucleotide sequence ID" value="XM_038198013.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198013.1">
        <property type="protein sequence ID" value="XP_038053941.1"/>
        <property type="gene ID" value="LOC119726357"/>
    </dbReference>
    <dbReference type="GeneID" id="119726357"/>
    <dbReference type="OMA" id="QHPEETI"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="498"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154729" checksum="073C8337EC114436" modified="2023-02-22" version="1">MATKFPEMQWDASDLAEEFKIFRQRIELCLADQDITDQAKQAVKIKIAVGKEGLRKINASSLTEDEQRDPSKLWDLFEKQLKVKLNFRIHRLELMRYRQKPKEHLDEFVNRCRAKAVECQFTVEELTERVVELVIASTPSESFQKDLLDRPIGYSIDEMLIEGRKYEAIVAGKQSLQSMETGGASVNAIWSKSRACRNCGLSHPPRRCPAYHDTCKACGAKGHWSKCCRKTRARSRQRRGSKSPRRRRSPSGERRRSPSRDRRPQQRKPKGRKKDESSTPNTTEQETDVHQLEYTDNAYEEVFHVVTVPDFHKKNDNTGNEAYRMLDVVCPDLEGKHRLKVKIDTGAGGNTLPLRTIRQMYGDTWRSQVKPVTTKLTAYNGTPIPCLGSIDLLCRYQDPTWSENRFYVVDVTGPVIAGLPMCRDMGVVTIHAARLTSVQSIEQLMEAYPDQFDTIGSFKRRATLYLKEDAVPHIDPPRKYSVHLKPKLKVEIDKMEALGVIRRVAHHTDWCSSITTSLKQDGSIRVCLDPKRLNQSLRRCPHKIPTLEELNPEFSQARVFSKLDAKAGYWAVHLDEKSQELTTFRTPFGRYCFQRLPFGLAISQDIFQQCMDEIVDQVPGCVCIADDIVVYGRTDEEHDANLRNLFEVAGREGLVFNSTKCRIKTKKISFFGSIYSDVGVQPDPGRVEDIHNLPTPQDKEDLQKFLGLITYVSAYIPNLADKAAILRDLLKKNIPFVWQEDHQAAFEALKLSITADACLQYYNPEMPTVLEVDASQKGLGACLTQHGKPIAFASKSLSPAQKNYSNIERETLALVFGIARFHNYLFGKEFVVYSDHKPLEMIWRKPLSSAPPRLQRLLIKVQGYNFTVHYKPGPTMILSDALSRLPNPKKNEDIHLDRLVGGIDVIEGPELKHIDLLHFGQTKQTQLQVQTARDPTLSSLTQVIYAGWPDEIKELPRDLRPYWPYRDELGISWGVIFKGKQVVIPDDLRQDILAQLHTGHMGIEKTRRLARETVYWPNISRDIDIAVRACEYCQENQPKQKKEPLHPHEIPSTPWTKIGTDLFEIGGDDFLLIIDYTSKFPVVHRLRDTKSATVAGVTSRTLGMFGAPAEIISDNGPQFVGAPYQDMCASWGISHITSSPRYPQSNGFVERAVRTVKTLIKRCQKSKQNVDKALLNLRATPIDSKLPSPAEILFGRPPCTSLPSRRPYTEARHEEMKDAHDKRRDRMKADYDRRYSANELPPLHVGQKVRILDQDSRAWLPGEVTTVCREPRSYKVATPNGSILRRTRSHLREMTDSRHSITPKRVRFADTEKTKDLSKQHKLPNHSNNAARATGDTPQTTRSGRVIRRPVRYIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSJ8</accession>
    <name>A0A913ZSJ8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054602.1">
        <property type="nucleotide sequence ID" value="XM_038198674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198674.1">
        <property type="protein sequence ID" value="XP_038054602.1"/>
        <property type="gene ID" value="LOC119726814"/>
    </dbReference>
    <dbReference type="GeneID" id="119726814"/>
    <dbReference type="OMA" id="RETCESH"/>
    <dbReference type="OrthoDB" id="6048873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="646" mass="72896" checksum="CB2086588091346D" modified="2023-02-22" version="1">MASNVTAQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLKCLQELRQSQDPSGTKLTCPLCRRETMLKGSGVADLPNNFAFSALVEEVTMQEKLLEGQGSDIKCQNCDEENQATSRCMDCDNFLCQECQKAHERMTFMKSHKIYTLAQLRSGEIVYKSKLREDIPKCGNHPDQNLNVYCNTCQQVICTTCSVLDHAKHSLIGLPVAFEKCQKKVKELVASVSKSKTKLNNSIEKTYKSRKKLNTMFANTNKKITEKADQEVAKIRQEEQKLLKETDRIYQKRVTTFDAAQANNSKEVTQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDKLTFMDFEEGERSLGRLILEEEPKAAAKQSPRPARSCVKKKWELKTEINNFELGNTRLRHVSALSDNNIVLPTWYKTLFTVSLTKCQHTPSPIPQRLQINGLAHVRCIAVSKDDKLLALNGPVVKVFNKQHQLLHQFTPGRGSYSLPTCLAVDDSNLIAVGYEGKDEISLHNPDGSLIRRLPAPMIRGYLTMHNHRLIYTNWPKQRLVCVDYYGPSVFSVDMTSNIHEDGHPAGVCCDSDGSIYVAVDEYPTGDILHYSPDGKYIGCVIKDCGRPYGITFTSGGDLVVAAEQSVKVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT16</accession>
    <name>A0A913ZT16_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTF3C1 extended winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054325.1">
        <property type="nucleotide sequence ID" value="XM_038198397.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198397.1">
        <property type="protein sequence ID" value="XP_038054325.1"/>
        <property type="gene ID" value="LOC119726641"/>
    </dbReference>
    <dbReference type="GeneID" id="119726641"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="2">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1849"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1909"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2072" mass="231828" checksum="34E9B7586105AE25" modified="2023-02-22" version="1">MNVLQVIHHSDKCSNGIESLKLLKKLSDDKEEAAEEDSSNNYDPSTSQMVAELPILTQAYNLIDRMQHTRQGITYSDFDRLLQKDGRFMRRLIDRNLLKHNLIKFTMSDKGRQRIRRFQTVDKVTKSTPKKDANSETQATASTSETKVPPHNTTERYRKRRQRVLELIQKNRVQEGCFNMIKEIRQEEAQEGRTTVCDRKSIFRILDQLNKEGLCQTFSTVVMSDDGTESRTCKIILDVGVERNDPRVLHIIQQVKLRMISYKLHHPPPNHTKGKKNKMKIARPVKGRKSRSKGADPLLRKRITQYATLAQPEGSETKTRPAGSRIATHEALLGKTGNSDGDEDVKKSESEDMLPVERQYVPKRNVYGLLPKMGKTMVLHRFVWYLLYGMPRQKSPKAPQSADNIPGSSGNETMIIKQEVDESQQSQVSGELEPLQATFTTGQLQDSNNLIGQSTNQSELTFSSAGQSENLSEVDNSMQCQTHAQRETPIGGQEQTAMSVCQVESAMHLADQSEELSDANSGNQNQSESAIGGLKRTAEGANGQTTSENGLKVSTSEGSSTQSELASAGDLLAIIESGYLPEKLTTSLPTDPVSSLEFTAPNMESGMPNFESTNPDLESAMPNLASTVANLERSVPNLESASPNLEFGASISNVNPASTFPVRQDARNLLLSRVKVYLDVMDWRRFVKPLPEYKDLPHGWCLLGDLFLSMPLVTFCEIISLRYMIEGLEDYLKDPLLKLLLIKDLPDRLRNSLLEERRYIYNMDSNVDLLCTLGLGVYTPHLNENKDVLSMYICRNVRIVDTTSSQPGFYYISDKSYPILKYNLRTLDDVEKYWFDLKVICLDTPLGFVKKNVKGKIIKTKLTGFARKADSYLDPVIEDGRIPGDGKGAGGFDSSLYCHLKRNWTSNVLEAGYMCKQRYHNRFSKGQRNTSERLSNPLKPRTVSLSTRKGVKEKVAVETKLVNVDEHKAGRVGGKGLKRKRSPKPKKESEASIAQKKRREEKKRAKEEKKQQQRQQRAVGIITRKVFSWTPQEDSVLLLCKVASEILNTDQSFKSCITWETIQRVFAKKVPDSVNMEGKDAKVISTRCYRHMKNPDFRTNFSVCLGEVKEDKEILDSIKPLSDRSSIEAASEEFEKLFNKLEAKFRFAEEFNTVLPDDITSLHSNYNVVPIVQTDPTNATFFKDENATDLKRLTLHTIVLSTLSSQNASDYDARLVFKLYEQYDNRLLHDVFLFCRSTGIVNRCSKPKRRIMPCVPMSYQLSMGYIRHFKARMPHELPDEAARCQEKLLESAPEEDVTFPQVSCGACSCQIFLLSTDQLNCKIVIPKKVIVLDSNLIDQEFLKQSGLLKKSGDFSDSDSDTDEDSEEDENDEEQSDQNEGRDTQIDGVGMEDSETQGIGVIDRVRNVTGVRFDEDNDDEKTTGQAEAMEDQQALDSSISVVEDDANDRSVMDQLNELAEGLVSIESQFSDAIECPSVQQSVIDMDHSYLASTSTVVDHDQPTVNGSGDRGETSLPKSEGTVTGYGDGSGDASQEVWTADPRFSLIDEVLYGVGSSKRQETASPSQAHLKPQPRNATMKCLSYDQVSFTKWLILRGHYAPGVCGKKISTLQENIAFNAFIIKLSLNESSPGVPCQSRPEFQPCASLLEYLLRPCKKFVYLEPVWKPTELGQEASYLEELCQGKVFEQQGDSTQELTQRFTGIGLDAATTTALIQIYEKIKEAGFLGVTVPEVKRIVGRVEAASTVKLSLEKYINLLLDQEMIVEVGSNDLRIVATKHASLWMIHSHRLVIPAKSADSDPLAKRPCLDRLSDTCLDLPSRNELVEGESSNTEIVDLTGEPLVPQLQSEYSVEKISMSEPGQRLSPLPGSGQVLEVTPEDDPLAEGSGGKGHQEVTVVGSPEDAAEEVLEIGEATDTMRESSDGGEASLADRSSSTDSDHGRAVKRKFATVIDGVYEPVDFVPRPWCKVNGKVNRPELCKMIRGIALKILAEPGIKESQIVHHLRIIFRKVDSLKLLQIMSDLGLITRHCVTLPKPSLFGRTKSRSQPTVYYYHPSINCLTIMGALFDEHQDTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTQ4</accession>
    <name>A0A913ZTQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054185.1">
        <property type="nucleotide sequence ID" value="XM_038198257.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054451.1">
        <property type="nucleotide sequence ID" value="XM_038198523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198257.1">
        <property type="protein sequence ID" value="XP_038054185.1"/>
        <property type="gene ID" value="LOC119726527"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198523.1">
        <property type="protein sequence ID" value="XP_038054451.1"/>
        <property type="gene ID" value="LOC119726716"/>
    </dbReference>
    <dbReference type="GeneID" id="119726527"/>
    <dbReference type="GeneID" id="119726716"/>
    <dbReference type="OrthoDB" id="5857313at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324097" description="SRCR domain-containing protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="379"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="54106" checksum="D6647B197B42696B" modified="2023-02-22" version="1">MFTGVMKTISLAWLLETLILGAFWQSAKSQSDGDFRLNVSIPGSNLKKLEVFFVEKWGPVCANNWQLRESMVLCNQLGFQFVGSWGPDAEDQGVQGNLGYVNCQGDESSILDCSHMKRTNTSGPYCLVSGVVAMTCVETRGQGAQVSFVDGDASTEGRVEVRFQNGDTTFVYSICDEGWDLADADIACTTEEPPNGPALEAVGGSYFGEHPSASGSNEQFDGYLASGLQCDASATYENLIGCPNSGWFPKNCNKNAGVKCQRKPDALPMNITLIDGTSNYEGFVKVTLSDTASGSICSQKVLTLREGDVVCRSLGYGYALSVSEGKSSLQPVVFDLHCDGNEQSLTECVFNAGGNCDRGNTLEAKVTCSGPLEANKYPVELTDQLGARDKKGLLRVFRDGRWGTVCKTGWTKEDAQVVCRQLGYSSVVSYVSEDESGSGPIYLSNVDCDGTEQSLDQCQHDGLGVHEGCSHMMDVYVECGSAMMVCNAILIAALASLAKFLSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUG2</accession>
    <name>A0A913ZUG2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055212.1">
        <property type="nucleotide sequence ID" value="XM_038199284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199284.1">
        <property type="protein sequence ID" value="XP_038055212.1"/>
        <property type="gene ID" value="LOC119727418"/>
    </dbReference>
    <dbReference type="GeneID" id="119727418"/>
    <dbReference type="OMA" id="IDAYMSF"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23829">
        <property type="entry name" value="RWD_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="313" mass="36422" checksum="7E3E7DA3906AFB42" modified="2023-02-22" version="1">MEKRELIELQLSEVEMLQSMFPNEEFCMDDLSVISEARNIVECDDHDDDHELEVEGLLAEFRQITFTIKIKIEEPQCDLQVICLLPERYPQDVPEVLVRSETPLFSRQQQKRLNDDVAEHILSLDRGELCIGEAIQWIRENTYKYVEPPSPSKDKSVSNKNMSKKTKEDDTFTRLWIHSHHIYSKFKRRDILDWGTELPVTGFCLPGKPGIICIEGEKSFAEEFWNRLRRMNWKKISCKHREDVPLCDGKGQSTSTSDLRRFSGFEEKEFAVSSGRDYHMDLGMFFKFLEEHNCGSVFKILLGVDGKVSSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV89</accession>
    <name>A0A913ZV89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055185.1">
        <property type="nucleotide sequence ID" value="XM_038199257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZV89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199257.1">
        <property type="protein sequence ID" value="XP_038055185.1"/>
        <property type="gene ID" value="LOC119727387"/>
    </dbReference>
    <dbReference type="GeneID" id="119727387"/>
    <dbReference type="OMA" id="HTQEIRF"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17615" checksum="6798F5E0989FC9A5" modified="2023-02-22" version="1">MPYTEATLMEVYRYGVSAPVGLPKSTTRDMTFRGFKIPKNTMVMVNQWAVHYNQDHWDEPFKIKPERFLDASGLQLIKPTESYMPFGLGRRSCLGENFAKGEIFILFCWLFGRYSFTKVPGREGESLIRKDESQGLTQYHPYPYEVIVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVA9</accession>
    <name>A0A913ZVA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-33B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055011.1">
        <property type="nucleotide sequence ID" value="XM_038199083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199083.1">
        <property type="protein sequence ID" value="XP_038055011.1"/>
        <property type="gene ID" value="LOC119727220"/>
    </dbReference>
    <dbReference type="GeneID" id="119727220"/>
    <dbReference type="OMA" id="PLWIEEC"/>
    <dbReference type="OrthoDB" id="10006973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04115">
        <property type="entry name" value="Rab33B_Rab33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041822">
        <property type="entry name" value="Rab33A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26704" checksum="BD1A65E852D4BC71" modified="2023-02-22" version="1">MDQNEKQPAEADDMDGFVAVEKQRRIFKIIVIGDSNVGKTCLTYRFCGGKFPEKTEATIGVDFREKNVTVEGETIKLQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDITKMSTFEGLPNWIDECDRHSLSPDIPRIMIGNKSDIEDRKVVATSIAQKFADANSMPLYETSAKMDEDAEKVEGIFMELAVQLKNYRPILPLPSHYQKEKEEGRSTVRLPTSPGSQKKDSCCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXE3</accession>
    <name>A0A913ZXE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056313.1">
        <property type="nucleotide sequence ID" value="XM_038200385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200385.1">
        <property type="protein sequence ID" value="XP_038056313.1"/>
        <property type="gene ID" value="LOC119728231"/>
    </dbReference>
    <dbReference type="GeneID" id="119728231"/>
    <dbReference type="CTD" id="4713"/>
    <dbReference type="OMA" id="FVYQCAH"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="126" mass="15240" checksum="23B9FF3B9479C920" modified="2023-02-22" version="1">MGHVWSAYVTSPDTAPDLHKLPTFNPLYGFPEGREERVMIATQEEMNKAQVPLDRRDYCAHLFIAWYKCRRDNFPNVFACKHSKHDYEHCEYGDFVMRMKEYEREKRLLARAKRKRLREEKEKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0J2</accession>
    <name>A0A914A0J2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057398.1">
        <property type="nucleotide sequence ID" value="XM_038201470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0J2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201470.1">
        <property type="protein sequence ID" value="XP_038057398.1"/>
        <property type="gene ID" value="LOC119728993"/>
    </dbReference>
    <dbReference type="GeneID" id="119728993"/>
    <dbReference type="OMA" id="VQNWATL"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000260">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000267">
        <property type="entry name" value="Voltage-dependent calcium channel subunit alpha-2/delta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF43">
        <property type="entry name" value="VWA N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22673">
        <property type="entry name" value="MCP-like_PDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037524988" description="VWFA domain-containing protein" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="262"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135503" checksum="372F197E51BE5F8E" modified="2023-02-22" version="1">MVAMGTAVFLCHCLVATVLMLPCTETLNYNEIDHDEGPGYSYASEDGGGRLVGHVQNWATLIQNYILQLASDGLKTEYTQSYYDNADYIYQKKNASNIVAHVKKLLDSYFARKEDVAKRIANAVKRLHDDNLGKIIYRSLPEMPKEIYKDSDIPGRLPKLEYNAYFRQAVSTESSTVKISDEVPRESQDTVNAVFYTKDLDDVFISNFNNDSSLRWQYFGSVEGVLRKFPGREWSRNFAGFYNDYDPRVRPWYITGTSDPKDVVIILDCSTSMEGKKFDIAISLVRIILDTLTKQDYVNVICARASHWDEVGDWYPFNTTVLSCKDDRLVPATTAHRKDLKEKTGELKPKGTSELKRGFEKAFELLSGKSRTGCQALIILVTDGKDTDGETVRCGPGYYTRSGYVPGPICKYDWSKVWNRVKELNAVAQPQARIFSYGTIDAGEIFPGHLACKNRGYFKKLTDGENLIGKMRDYFNFLSSNSQQTKDFEGKWTAPYIDAFGLKQMVTHAIPVISDRTEKLLGVVGVDCTLEEIENLIVNEQWGSVYAFLIDNYGGTIFHPLLKPSSDLVEDPILVPIRQLEQPEGQPEEFSAVIDAMLKGETGYREIKNAQRGVPKGSFSDGVKRQVMPATYFYTHLDKTDYSFAFSLAKTDEVFRQAEEPKDRSHLQPTSYFNLLKEYNSTLGRQELPGEFEKMQVFYNEPKYPDLRVSYLYSSFFLAPRCYCDPNVYLVDDDLATKTVAAHKFINGWDPDVECPKDDKKNKFRKGIRADVLITSQIEKIWRSRNKKMLQDVKWTYIGCRSGVFRTYPGHRSKRYYDPTKRPWYHRVITNSDKTSISTAYMDSAGVGKIISVSQAVFEGMPTIDEEQCDLVDGKKPGGCKCSTDADCVSARCYKSKAVNLTDTTRCASVKVEAVTSLDILYNDFHLNVFEIMRDIDMPLSCQFTYPCPDGEPGCSTRCYLFDNSANIVIDPQFISISDLDTAKYNRVSLGKKEGEIMRELIYKHRFFFRKETIDFQGSCSLSSSSPRVNLNGIAKTPGELDDYYKNKGPIPNFSNKFGCIQDVVGYQANSSVLEPSGMIIGNISGSCKSGFYYVKALPKTNLFLLVVENWRNYRESMYFNFNCRITNRVSATGAFRIINGTCAHEDDTASLASLNRCPVSTNYEITNCTYNTGTPTNTQLAWSLLLVGLGSIHLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A138</accession>
    <name>A0A914A138_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038057066.1">
        <property type="nucleotide sequence ID" value="XM_038201138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A138"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201138.1">
        <property type="protein sequence ID" value="XP_038057066.1"/>
        <property type="gene ID" value="LOC119728761"/>
    </dbReference>
    <dbReference type="GeneID" id="119728761"/>
    <dbReference type="OMA" id="ELFYTIH"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000112">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="41726" checksum="0C22CA6B8CE08A95" modified="2023-02-22" version="1">MGANASALEKEIGSDQFPTNEHYFGLVNFGNTCYCNSVLQALYFCKPFRDRVLGYRAQPKKKENLLTCLSDLFNNITTQKKKTGVIAPKKFIGRLRKENEVFDNYMQQDAHEFLIYLLNTIADILSAERAADKQVSKPNSKVSTPNGSLSNNNDHHHQKNEPTWIHEIFQGTLTNETRCLCCEGVSSKDEDFLDLSVDVEQNTSITHCLKGFSNTETLCHECKYYCETCCSKQEAQKRMQVKKLPQILALHLKRFKYMEQVHRYTKLSYRVVFPLELRLMNTSDDATSPDKLYDLVSVVIHCGSGPNRGHYITIVKSHGFWLLFDDDLVDKIDVSNIEEFYGLATEVQKTSDSGYILFYQARDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1I9</accession>
    <name>A0A914A1I9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057221.1">
        <property type="nucleotide sequence ID" value="XM_038201293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1I9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201293.1">
        <property type="protein sequence ID" value="XP_038057221.1"/>
        <property type="gene ID" value="LOC119728862"/>
    </dbReference>
    <dbReference type="GeneID" id="119728862"/>
    <dbReference type="OMA" id="DDHAPRN"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="52676" checksum="72C0CBDFCAEF4013" modified="2023-02-22" version="1">MALLDLRPFLKKYRGCFMVYIAFVELFIALGPPYGYTILFARLQDEFGAGAALTGWVGSLATTLVFCSPVSPLLLQRLGPRAVALLGTVVFSAGLVATSFVPALPYAFLTFGVLVGVGGNFLVQSVVLVVFKWFPGRNCSRATSIAWLGTPFGTLAFAPLLTRLITAYGWRNCLRIVAGGSFVLSVAHAAFIALPNEKTENRETPESKTIDEHETVVDDNAHSAAAKECQTAEIDDHAPRNLRHQIGKLLLQLDTWAWLFGFLMSNIGWTFVVINYASFMEYDLHLTPDQITVALVLAAGGEIVGKILFSIFGDRLPCLKLYVVAATGFLAALMSGLMTVLKTLSLVYIISFVVGMIRGVSYVSPCPATMELFGDYGSNVVTALFMIPMGAGILVGAPLTGGLYDLKGDYTLSLYVTVGVFVCAALSMLSIPIRRRLRSGTNTSDRVCRSETETQGVYRSTTTAQISLDNPVFEGSRTDDDRVLSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5Z3</accession>
    <name>A0A914A5Z3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058821.1">
        <property type="nucleotide sequence ID" value="XM_038202893.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202893.1">
        <property type="protein sequence ID" value="XP_038058821.1"/>
        <property type="gene ID" value="LOC119730107"/>
    </dbReference>
    <dbReference type="GeneID" id="119730107"/>
    <dbReference type="OMA" id="ISTGWPR"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF14">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="467"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1326" mass="148977" checksum="58ADF195DA976817" modified="2023-02-22" version="1">MAGSLIGRIDPFDRTEEDWPTYIERLDQYFAANAITDDRKVPAFISLIGPKTYGLLKNLIAPEKPSTKSYTELVDVLRKHLAPKPLVIAERFRFHKRDQREGESVTAYLAELRRLTEYCEFGSYLNDALRDRLVCGLRAGNITKRLLAEAKLTLKKAIEIATAMEAAAKDAVEFQQQLKPETSVHKFAAKPQPTSTSTCYRCGKSGHSPNQCHFKDATCHGCNKKGHIRPVCRSSTSPQQASRPRNSRKGRPQGGKVKAKPMKSVEEASSDDDITYVGRLRVNNLDHRKDSTIWLTPSINGTNIRMELDTGSAVSVISKADYQRHFANSKLESTPVKLQTYTGEKVSPVGCLQVDICYQEQRHTGLLYVVQRGGPALFGRDWLAHFKLDWPSIFAISSEHPPVNMEAKLQALLDSYPELFKDEIGELTDIRAKLTLKDNAHPVFLKARQVPYALRPQVEAELAKLQQQNIISPVETSEWATPIVPVPKKNGGVRICGDFKVTVNANLHVDHYPLPKIDDVFATLAGGQHFSKLDLKQAYLHMVMDEESSKLLTLNTHKGLFKMNRLAFGVASAPAIWQRTMEQIIQGIPGVQCILDDMLITGRDNTEHLRNLEKVLSVLRDRGLRLNKSKCEFFKSKVVFCGHEIDARGLHKTQDKINAVKNAPRPTNVGQVRSFLGLINYYHRFLPNLSTVLHPLHQLLEKNHKWAWSTECETAFEQAKTLITSEEVLTHYDPKLPVKLACDASPYGLGSVMSHVMPDNTERPIAYASRTLSSAERNYSQIDKEALALVWGVKKFNNYLCGRKFTLVTDHQPLTSIFHPAKSIPATTASRMVRYAVFLASYDYEIEYKSTTKHCKADGLSRMPLPEVRVEHTDPDDILHLSQFDTLPVTSAQIRKETARDVVLAKAYEYTMKGWPHSHDSELNPFHARRHELSVHNGCLMWGLRVVVPAKLRDKVLIELHEGHLGVVKMKTLARGYMWWPGIDSDIEKLAKGCSGCQLVQHNPKSAPLHTWEWPMSPWQRIHIDYAGPFLGQMFLIVVDAHSKWPEVVSTKSSDSSHTIDILRAIFARNGVPEQLVSDNAPQFTSDEFQMFLKRNGVKHITSAPYHPATNGLAERFVQTFKQAMKSMTGEKGTTSAKLASFLLAYRNAPHSTTGQSPATLFMGRNLRSRLDILKPNIRNHVSSKQVDQATSHKSASVTREFHIGQTVSVRDYRGKQKWIPGVIHARSGPLSYQVCVGPNMIWRRHVDQLIDSDTGKPPDLNTPHDAVPEILVPDPVIPASLTATPEQAVPSETLTPAEPPLPASPKVVERRYPSRNRKPPDKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7P0</accession>
    <name>A0A914A7P0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-dopachrome decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.84" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038059446.1">
        <property type="nucleotide sequence ID" value="XM_038203518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7P0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203518.1">
        <property type="protein sequence ID" value="XP_038059446.1"/>
        <property type="gene ID" value="LOC119730543"/>
    </dbReference>
    <dbReference type="GeneID" id="119730543"/>
    <dbReference type="OMA" id="CEHKNEN"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033981">
        <property type="term" value="F:D-dopachrome decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF22">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13472" checksum="0B3FEEA5A363EF0A" modified="2023-02-22" version="1">MPLCELNTNVPRAKVDESFVKELSQLVASIVDVPEKGVTLQVNPDQLMMRAGTLDPVVTVAITGFSTKYFTDAMREKWVTSLTTFLSEKLGITDHGRIIVAFHFIEATHVGFFGKLASSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A844</accession>
    <name>A0A914A844_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ependymin-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059990.1">
        <property type="nucleotide sequence ID" value="XM_038204062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A844"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204062.1">
        <property type="protein sequence ID" value="XP_038059990.1"/>
        <property type="gene ID" value="LOC119730982"/>
    </dbReference>
    <dbReference type="GeneID" id="119730982"/>
    <dbReference type="OMA" id="TIPLLCH"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037471217" description="Ependymin-related protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24444" checksum="4F0DDC01AC7EAB8D" modified="2023-02-22" version="1">MATKSVLILLLVVVATTFAQKKCCYPSQFEGSFGSLVATVTGGQGMTQSEGWQYAYDYTNGRMATINYRESQGQMIKYQDIYLYSKGVAYIVEIGPGFTICQQISINGTLPHCIPSSATYLGSSYYGDHKLNVDFFKFFESMSSSTYANITMTVSQGDCIPFSVVEEGMFDGVPKLRIRGYVNYTSGISDPSKYFTVPSGCPPSNRETLNMRKSPFDKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9H9</accession>
    <name>A0A914A9H9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038060091.1">
        <property type="nucleotide sequence ID" value="XM_038204163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9H9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204163.1">
        <property type="protein sequence ID" value="XP_038060091.1"/>
        <property type="gene ID" value="LOC119731138"/>
    </dbReference>
    <dbReference type="GeneID" id="119731138"/>
    <dbReference type="OMA" id="YIHASAM"/>
    <dbReference type="OrthoDB" id="6428779at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="135"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="459" mass="52223" checksum="EA53F6CB7EDCE46F" modified="2023-02-22" version="1">MAVSKAGVLSFILPVFLAGLVTRPLILEDYAKQLANHVQNANISVEVVSEKINQVAHSSDFKFVLVYGLAAVLIYLAVQLYKAVTEPLALYCDETKYTYLVDGPADGKSAEERVRDMKRCRKVGDVPPVYPNGWMSILMSSELKKKEHKFVSVAGKNLVVFRGESGRPYVVDAYCAHLGANLAIGGSVHGECIECPFHGWRYRGEDGKCVHIGYAEKVPDFVKIPTYQCCEVNHRIWLWHHAEGKEPDWQVPELEHLTNGKLQPVGFTVCELDSHNEDTPENGADVSHLDYLHGPRAFAGQAHFSDVSWEPHPTIKHVAELRMTNQHHELFFGLLKLPKNTFQIDQIGPCFAHFHMDSPMLGELQLVLTVTPIGPMRQRIVTTGYTRRGPISFYIGKRVLYEQFYQIWGDLPVWANKKYVRNPPFVKEDHLIAKHRRFFAQFYSENSPKYDPKEESMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA47</accession>
    <name>A0A914AA47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CIDE-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060727.1">
        <property type="nucleotide sequence ID" value="XM_038204799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204799.1">
        <property type="protein sequence ID" value="XP_038060727.1"/>
        <property type="gene ID" value="LOC119731603"/>
    </dbReference>
    <dbReference type="GeneID" id="119731603"/>
    <dbReference type="OMA" id="KAEHVEW"/>
    <dbReference type="OrthoDB" id="9943677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039729">
        <property type="entry name" value="DFF40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015311">
        <property type="entry name" value="DFF40_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067:SF2">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09230">
        <property type="entry name" value="DFF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="38687" checksum="CC1AC5C339479BC1" modified="2023-02-22" version="1">MSVPKALKVRGVSRPDKIGIVARTLREALLKGCDKLKIPYDGTQIHLEEDGTLITDDDYFQTLQTNTCLVLVEIGQSWLGGFDMFKRSLEDALAALSQGNLSSEIEAFLKEKLSTTRQALVEFVYSQQGNIAAERRDEDPEWFQGMDQRFKTKSHVMFVKAQERVRGYFSKTKEMLANESTNYTRAALDRRARVITALKDGLKEKEYHGVYFKRNADCEARLCDLLGWFSCQGAYDTTECCYHHSINPYLNKESMILFSTWNLDHVIEKSRSVIPGLEEAIRNCPAQKEVNVPYFYDLLFTRKNLKLVDIRCHKKGIHTGRVDKKRFYRRPTGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB72</accession>
    <name>A0A914AB72_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060998.1">
        <property type="nucleotide sequence ID" value="XM_038205070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AB72"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205070.1">
        <property type="protein sequence ID" value="XP_038060998.1"/>
        <property type="gene ID" value="LOC119731797"/>
    </dbReference>
    <dbReference type="GeneID" id="119731797"/>
    <dbReference type="OMA" id="HRSANRV"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="37331" checksum="1D231DF4C206C105" modified="2023-02-22" version="1">MAEQILLLRIIKTFVGIIGLFGNGLVCLVIYRVPALHTMTNAFIVNQAVADLMGSVFLLLLSNIDYPAILPEGTAGVLLCRLWISDFFLWACFITSTFNLVGLTFERYVAIVFPFRYPTFYTKRNSCFMLAAAWFLGTMFATYSIAIRAYEGRQCAEKLLPYLKDVGFVITIIQYFVPTFTMLFAYIHIIVVLHRSANRVGVATASTATSDGREASLLRARRNTFKTLLIVYIIYFCCWTPNLTVFAMFNLGWPLDFKGALYIISVALAASNSCVNPIIYALKYRQFQNGLKRLWMSIRGREHVENVSWMVEQSADRLTYAQAQHNHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADG4</accession>
    <name>A0A914ADG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Elbow/Noc family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061384.1">
        <property type="nucleotide sequence ID" value="XM_038205456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205456.1">
        <property type="protein sequence ID" value="XP_038061384.1"/>
        <property type="gene ID" value="LOC119732079"/>
    </dbReference>
    <dbReference type="GeneID" id="119732079"/>
    <dbReference type="OMA" id="SQAPHMD"/>
    <dbReference type="OrthoDB" id="10054079at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN ELBOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="471" mass="49312" checksum="78B494079447C537" modified="2023-02-22" version="1">MLASRPLMHTEYLQPLDPLPTTLDAKKSPLALLAQTCSSIGKPDPPPSSNDAKQAATPIGRHTPSGKHSPEKASTAAGLPESSSGFKPYKQAEKRDGDALVIKIGYGKDKREAKSPLGSNSPRSPLVKTKMEPATTPTSRPGSTDASTGHSGSEGNKDTTTVSKPTAPVQAAQVAPSHLHHSSYPGHYKHGLLAASHAGHCGCPSQVVGHVPYYPDPAVAARDPVSVHSLKHEVNPLLAATASPYTAYARVKTADGGTTLMPICRDPYCTNCQSAQHYQTGTPSGCTQCRHDTFALNAPLPIALPLPGSMSPYLSSSVSSSVHSTPYLYPHPITTTSQEHGHVCNWVSGATSCGKRFASSEELLQHLRTHTMTNSEVPTSSALSATLGAQLSAYYMQYPTAAAAAAAAASFGLPKPGFPTPLSPVGAIRYHPYSKSPSPIAALPGLPTGAYYSPYALHDIKSRFATAGLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADZ9</accession>
    <name>A0A914ADZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061579.1">
        <property type="nucleotide sequence ID" value="XM_038205651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205651.1">
        <property type="protein sequence ID" value="XP_038061579.1"/>
        <property type="gene ID" value="LOC119732216"/>
    </dbReference>
    <dbReference type="GeneID" id="119732216"/>
    <dbReference type="CTD" id="147015"/>
    <dbReference type="OMA" id="VADRCTC"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="37578" checksum="1D8ADDDFC112823A" modified="2023-02-22" version="1">MLELTSVTLGQWKLWDGPQYHGFCLGVCVSVALVMCVSVYYYFVKVADRCTCTTRLDGKTVIITGANTGIGKETAVDLAHRGARVILACRSESRGIQAEREIREQTGNSHVHFMRLDLASQESVKEFAQEFCNREDRLDILINNAGVINDGSAQTAEGYELSFGVNHLGHFLLTNLLLAKLQSSSPSRVINVSSDAYQLGRLGFQDGAGLLCGKEGRVKLYARSKLANLLFTHELAKTMEGTDVAIFALHPGSINTDIKRNWAWWLRTLSPLISFLFLKTTTEGAQTTIHCAVAEDLQKHSGKYFKGCRVQKVAPMARDDKLSRKLWRVSLQMTGLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFB3</accession>
    <name>A0A914AFB3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062432.1">
        <property type="nucleotide sequence ID" value="XM_038206504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206504.1">
        <property type="protein sequence ID" value="XP_038062432.1"/>
        <property type="gene ID" value="LOC119732925"/>
    </dbReference>
    <dbReference type="GeneID" id="119732925"/>
    <dbReference type="OrthoDB" id="10522964at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18681" checksum="340AFF4B28C12047" modified="2023-02-22" version="1">MALQCRAPKRKCAAKSPGFYKRLTTIDLKDSQGGKNQYRDKKTWREGELFDIEILKEADDKVFVTYPGWDSKYNEWLPRSQCADVINIQCLSTPSSLDDGQKLFCANLRLDIKRNLLGKRKADPHISITRDIQFDVYEHFFGTQNKIRYPTNSELNDVLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFE4</accession>
    <name>A0A914AFE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062221.1">
        <property type="nucleotide sequence ID" value="XM_038206293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206293.1">
        <property type="protein sequence ID" value="XP_038062221.1"/>
        <property type="gene ID" value="LOC119732661"/>
    </dbReference>
    <dbReference type="GeneID" id="119732661"/>
    <dbReference type="OMA" id="AFRFEAK"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039655">
        <property type="entry name" value="HBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499">
        <property type="entry name" value="HMG BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499:SF4">
        <property type="entry name" value="ROC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="4">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="841" mass="93231" checksum="108A0132B5BB3CE5" modified="2023-02-22" version="1">MCQEFPGSPPAIINKDADSTGDLQSLSPETSLAYRRRVLLLGGSGSGKTSLAKSLVSGSSQTSDGTTESLDVHVWCPFNGTTYENLLEKELTGYERSLVLDVWDLAGRKVWQKFHHLFLTPATLPVVVFNLADQDSCDEVSKIVELIWAKVPGSKLIIVGTHVDQLGQEERNADKCQDILGVMRNRHAHCIQKIQQEIHNLRNLSESARTPKCNQKIKHLQEILERFPSPPTSIIRSSSKTAKGLDDVRRDILQSILDSNRQSSVEHSMPIRPATADVYDDIVTMRKDAHVVVSAHEMHELFTKHEVGLSSEVEANEVAFLETSGVIQCIIDFSDSDDNLICINPPVLAKALCQVHMSDTKKAFRFEAKRFWPKSDSGHSKKPNPAVLVQALEEVATEGLVRESMFPLLWQDLNMNEKQTRLIIDLLARLGLLNRAADAHGDAEKRSLELPNYPGLQARVQHRLPLLGLTPDMGPTLNWTPKPFKGDAQIGWRYTFPLGTPPGLVPRLFVMCRTNTPGAMYRHHWKNGLLLKMGQVSVNIKQPEASQVEKVDLYVRVTVDEEGDKKATEVLWVVLARFLVVAQRFLASWPGVYYQVSILPSSMYYTSESTVDELEINLLDIMREASLEKKTMKVDVKSQNCEVNVDCLMPLPGDSDLSISHWLQWLANLDIQLSESTPSINEPDDQISDNDSQSSLRPSPSPPRGNSPRVLTSPPVKTNKKAEIKWKLDNGWRRVSVEDELKEIKKVAASFVAAVLAGAVAQLITEQSRADDHGHTLMEREAKHAAALASARAAQAAQSGNAEAAAMAVVAAAQAMDNAMLVRKKGNKGTAMIKSRMCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG00</accession>
    <name>A0A914AG00_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062895.1">
        <property type="nucleotide sequence ID" value="XM_038206967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206967.1">
        <property type="protein sequence ID" value="XP_038062895.1"/>
        <property type="gene ID" value="LOC119733386"/>
    </dbReference>
    <dbReference type="GeneID" id="119733386"/>
    <dbReference type="OrthoDB" id="413122at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="114" mass="13330" checksum="5FB199DF675BB890" modified="2023-02-22" version="1">MLIGLRCWQPFFFLMYNKKARLPCEVQENIKVTQEKKKKAYAKRKGKNVNAFQLEEGMFVPKRNYKKIGRKGSKMEPNWIGLCRISNISDNNVVTLKSGDGRLKLKNKVQNEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH32</accession>
    <name>A0A914AH32_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063003.1">
        <property type="nucleotide sequence ID" value="XM_038207075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207075.1">
        <property type="protein sequence ID" value="XP_038063003.1"/>
        <property type="gene ID" value="LOC119733685"/>
    </dbReference>
    <dbReference type="GeneID" id="119733685"/>
    <dbReference type="OrthoDB" id="10043139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="34748" checksum="344882ACCAA9808B" modified="2023-02-22" version="1">MILKVPAVTSFFTKCLSQRIRHIRWAEKKKTQPPKRQSDNPLLSSAKAPRVGHVHLLQKDVSSLTADDYENHLAEVRREWSKGNTKNKNHLMLLLSETFACNQQWIKSLPDSKMEPILQKIPCYQDGSLVIHDFLKIIGESSLDSILNKMEIFLTVVESLIGTSTKEPERIIPVIRHVEKATAFDKGKGVKSKSVITIKEDISDDEVEEVLKTGDRDPPHLLVLKKGGTIAGTFVVGDTVSIMCHSTSDKSITSAMLTLIAVYYVFDLDYPKIYSQLLGTLQSHVVGGITFDGKKSAKFRSFSNVLDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHP6</accession>
    <name>A0A914AHP6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCR-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063242.1">
        <property type="nucleotide sequence ID" value="XM_038207314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207314.1">
        <property type="protein sequence ID" value="XP_038063242.1"/>
        <property type="gene ID" value="LOC119733949"/>
    </dbReference>
    <dbReference type="GeneID" id="119733949"/>
    <dbReference type="OMA" id="FNPIAAE"/>
    <dbReference type="OrthoDB" id="6050183at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="924"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1218" mass="130214" checksum="A61195683E7A3E9F" modified="2023-02-22" version="1">MAVVFEQGGRVQEFLHGRESAGLVFHQLFAQQEEPKDKKPNQAKKNKKDGVEKAKTSDKTKKDVSPDSIRFQPPNIELQGNASAFSIYATVREYVLERDMMERELILIRANSAAGKREESGHEAEEVAKTEDALRLPKVVGIGLRSVFVLIRDTHSSYPLLCARALQALLDMLQGQTPEGLSKEPDDMIDSLFELLLDLTIDHRQEGPENLPGLPSISSLSCACLLSLIIASGNTGKMLAGIAAILMSTGSLSQQAFKVPSILSSLQRSVHAVLLGKTHFPDWLTSGIPSQSQLDSWEVQNIDIDACCDNNSAIASDGSYLYIHTDTGLYKIGSGFSSTIKGHIYAANREFHSHERGWLGLARGQLLYKNVSQDQHSGAGCEAVVVDTESLKEIGTFEIPIIGGTSASLLFSDGDNIGCVSAVNDDTFVVQSFNPQSSPVLKTGELPVKLARKSLLAYGPWPGSGDKELHLEKQEIETGMNSEGMYVAAGKEFSLIRTNSGKVLFMGKAQSLGIKQTGQPSTKWSELPITKSPKIVQCSVGHDGYHAALLGEDGNVYFAGTARKGEDGDQVKGRRQLKPSKPKKMLKMDGKTAVYVACNNGSTAVVTKEGELYLFGKDTHNADSSTGLYTELKNVKVTQVALGKAHTCILTSSGAVHTAGINNKGQCGRGPALGHGAGKDGKNANMAQKEAVSPEDVCGNGGGEGANVAAAQLMRTLIAEGEAAADILAPGAEEDPEEEERDDEQCEHEWKADQCMICSLCGLCTGYGDSCVNTFQPGRNPGMVCGCGSGDSGCTKCGCCKVCAGEAHERRVLAPAIPPRDVGPDGGGNFLGALVQHGNILQHKLLAQLRYGMNRQQDGKHRRVGFIMNQDKGKDEGSTSGDDRDVERDYGQHVIHPPGPVTLPLPATQVACGLHHTVVLLKNGEVYGFGLGNHGQLGQGDSGSRTAPVQLQVPETVVQVAAGSNHTVLLGVSGNVYTCGNFQKGQLCRAILEESNAPGAVSHSRPGPVPDMGPQYGRKATWVGASGDQTFIKVDEALINPRMLENSLVFANQSVIGVVPRNGAAGVRCLMLSRLDGTCNSYTEQDTSFNYEDTSVCLDPLYNVLWCFSPASATITCHSVFQPSVRPIPTLPSSASVLTPELALPSPTPSVQVSRSHCALHMLACLDTLTAAQEAQLTVVAAQTERQCITKVYSKEDFNSVNRFEGESCGDFFSLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIE3</accession>
    <name>A0A914AIE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for mitoribosome formation and stability, and mitochondrial translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063492.1">
        <property type="nucleotide sequence ID" value="XM_038207564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207564.1">
        <property type="protein sequence ID" value="XP_038063492.1"/>
        <property type="gene ID" value="LOC119734207"/>
    </dbReference>
    <dbReference type="GeneID" id="119734207"/>
    <dbReference type="CTD" id="51116"/>
    <dbReference type="OMA" id="PYIFMEK"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000026">
        <property type="entry name" value="28S ribosomal protein S2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="262" mass="29422" checksum="C73C82BF638D0493" modified="2023-02-22" version="1">MAASMRNLFSQCSRFQSAIARNNYWSKASLSTFYRSQQRIGTAEQDDATSQSSSEITDSLKDPDYFKVKDLVSLQDLFDARVHLGHKDGLINPHMKKYIFGIRQNQCIIDLDQTAGLLKEALNFTAHVAHRGGIILFINRMPQFTFQMEQLAKDCGEYAHTRLWQGGCFTNAPIQYGPGTRLPDLLVFFHTLTNTFTEHLAVTDAAKMNIPTVGVVDTNCNPNLITYPIPGNDDSPSAMELYCRLFKTAVLKGKAKRNDTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJU9</accession>
    <name>A0A914AJU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063694.1">
        <property type="nucleotide sequence ID" value="XM_038207766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207766.1">
        <property type="protein sequence ID" value="XP_038063694.1"/>
        <property type="gene ID" value="LOC119734328"/>
    </dbReference>
    <dbReference type="GeneID" id="119734328"/>
    <dbReference type="CTD" id="5514"/>
    <dbReference type="OMA" id="NGPPQIW"/>
    <dbReference type="OrthoDB" id="2138378at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="381"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="767"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="926" mass="99642" checksum="0EB087240CEE5B06" modified="2023-02-22" version="1">MSNAVDPYQLLKALGPLLTADGAIKNEAQVPRIAGLMNGARKLVSRCIYVNILRATDNEQLLGSFVSSGGWELLNTWLQEAKESNNIAFLTNLLKALRKLPVTIGILKKNNTAKLIKQMSKTETDESLKALAGDVVSEWMKVIKQTHENSDGKPTSTSNVVKKKKKKLVKTDASKGENEKDAETDSNANPTSKKLKTEKESSAKSELNHERTKKENSSKMDPDAKRRLSAEGKSPKSEKTLSNVAKEENNADDNEEKPRLGKIKRPAHTKFRSTGLEKASTLPPFKIKKKSAEAPPIINKGDKAAPIKREGPIFGKSLLPPEKKPKLDTPTSSAPSKTTSSTSSITTASTSATSASNNHGRTKLIPAKAKLVHESSNFMDALNAPAIPVRKVKLKKSQPKPTSPTTNKPASHPDTSKGSRAKEEESVGKVESPQETKPDPPKFRFYSSGQNDEDNSEKSESKDEVSNADKKNSGGTGNLKLIPTKSKKCVKWKDDDKLVDILYFEMDETERENVNRPKDFRNAAHLEMVMERETIKNAKLQGEGASPSLGGNDLLPWHALVRIQVVDVPPVDYGVNSLEKGIQKQREMIVLQEIYFDKNMIPDTPKEPDPEPFEPKEPTRIPLEDETKRKPEDEETADSSQGSTPLYSEPMLPGNHSAHPPPHPGTLIIPQGITLPPGLQLDNLPPAIASLVQQIPANLPGGLPPALQAGSQGQPMPGPGRPNDPPSTSATITNVQNLLNSIMGNQGGAQPTQEELTNKLRDMLEPFKNQLPGSLGPPQPNLPGGPNFNPEGWGPRGPPGPPGPPGPPGPGPGPVRGRGGMGPRFGGPGRGGFNPRFNGPPFPNGPARFPGPGGPPDMPPRGPPRPLMGGGGPWPRGGGGGGGRGRGAINFAARPICRHFMTPRGCERAQSCQFYHPGINGPPLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKI4</accession>
    <name>A0A914AKI4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064113.1">
        <property type="nucleotide sequence ID" value="XM_038208185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKI4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208185.1">
        <property type="protein sequence ID" value="XP_038064113.1"/>
        <property type="gene ID" value="LOC119734635"/>
    </dbReference>
    <dbReference type="GeneID" id="119734635"/>
    <dbReference type="OMA" id="AVANCLH"/>
    <dbReference type="OrthoDB" id="10025024at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="680"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1011" mass="115708" checksum="ED05FC637FFDFA8D" modified="2023-02-22" version="1">MNSLVGILCRFRLRPVAFMCDVEQMFHQFKVEARHRDYLRFVWWKDGNFNNESTEYRMGAHLFGAVSSPGCANFGLKQIAEDYEAKYGSDAADFVRHSFYVDDGLKSVSSTSEAVTLIRQTKEMCAQGGLRLHKFISNSREVMENVPQEDQASNVKILDLLHDALPIERALGVEWCVESDAFNFCIILRDKPLTRRGILSTICSIYDPLGFVAPVMLVGILILQDLCRVQVDWDTPLNDEMRSRWEKWRKDLPLLEKLKIPRCVCPEKFGKVIATEIHHFSDASAFAYGQCSYLRLIDDKENVHSTLIMGKSRVTPLKPITIPRLELTAAVVSVRVSTLLQKELDLDAVTEVFWTDSKVVLGYVKNESRRFHVFVANRVQQIRSRSDPNQWKHVGTKENPADEGSRGLRVEEILTSKWLKGPDFLLERKLPPQESTEYQTSPEDPEVKKTSVLLVQTVKSAVELEHFSKWRSLRRAIAGCQKFMSRLMEAVKDKRGELTESYKSEANLLPRYCPASVEDLQRSERTIIKLVQSESFPEEIRILTSLNVNDGDIDRHLARKRNKSMKRTSSLFRLDPFIDNEGILRVGGRIRKADMSFEFKHPAILPRRHHVTSLIIRHFHELAAHQGRGTTTNAIRSNGFWILGCSAAVATQISNCVRCRKLYGKVQEQRMANLPDERLQPAPPFTFSGVDYFGPWLIKEGRKELKRYGVLFTCLASRAIHIEVANSLTTDSIINALRRFTAIRGPMRVLRSDQGTNLVGARSELKRALEEMDHDRLRHFLIERGCDYPEFKMNAPTASHTGGAWERLIRSVRRVLQALMEHSGTQLDDESLRTFMCEAAAIVNSRPLSVTTLNESTALEPLTPNHLLTLKSSVVLPPPGEFQRVDVYSQKRWRRVQYLANEFWNRWKGEFVQNLQARQKWTRRVPDVQVGDVVLIVNNNLPRNQWQLGRISEAIPGTDGQVRRVKLVVADRSLDVKGKRTRPVTTLERPIQKLVVLLKSQEHWGFPIGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKR7</accession>
    <name>A0A914AKR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064317.1">
        <property type="nucleotide sequence ID" value="XM_038208389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208389.1">
        <property type="protein sequence ID" value="XP_038064317.1"/>
        <property type="gene ID" value="LOC119734814"/>
    </dbReference>
    <dbReference type="GeneID" id="119734814"/>
    <dbReference type="CTD" id="84986"/>
    <dbReference type="OMA" id="RNQHINK"/>
    <dbReference type="OrthoDB" id="10061772at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="80"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="597" mass="67705" checksum="78F96BA219E0A574" modified="2023-02-22" version="1">MSAEYLCNPLYYVEAMRHKHPQVLNDWCCTELSHVLDFSGSDGLGQVLAGVVDVRQGKTFVKKFSRNKQRANSQSGIFGAPLTEEGYRQARQLIDFLKDYITKEGIFRIPGNSERQRRLKDKINCGLLVDLENDIFTAHDVACVLKTLLGDLPEPLLTDRHYPAHVQAAGLTYEMDQVQSLTEEIGKRYQAKNTQDHITALRYLFLMLPPVNFKTLREILELLYCITEQENLNKMSAFNLGIMFAPHILWPRYLTTEDLRNQVLVNKLNCGVEFMITQYHKIFKVPAKMLKRCEQYIKHGRLIDEEEPAVLDQMQPQDECDSKSKTALVIGAPQTPNVEVKKEQNQTEAALAQLYASVQEMPPSSKKRKLMKQFAKNCNMPGTPTRVKEDILLRSQEGYSRPRKHVRSKSVGDAICKHTEAPMHVKRRRAAPNPPAEHDDKIVQQRMNMRDTRHELVDQLQRNRSHTCTAPSTSKTTTAILAHPATYSECSVSPAKSRQKRKAPLTPKQREGQQLAAATKSSGVMKPVPSERSSLQSWKQQSDRPIHNTSQSNGSAVNRPVPKPRKLKENSQGSSVRHGSSHPKPKIGQKHELNSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL68</accession>
    <name>A0A914AL68_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038064179.1">
        <property type="nucleotide sequence ID" value="XM_038208251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL68"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208251.1">
        <property type="protein sequence ID" value="XP_038064179.1"/>
        <property type="gene ID" value="LOC119734712"/>
    </dbReference>
    <dbReference type="GeneID" id="119734712"/>
    <dbReference type="OMA" id="ECLLTTM"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000019">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036744696" description="guanylate cyclase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="545"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="892"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1094"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141562" checksum="42E8913404E02291" modified="2023-02-22" version="1">MMTGSRWIASLAVLWIVTLETLSQDPTQSTDSPSDLEEIRVGLLTAAKPPTESEFVNREGLVVSGAASLAIEHINSRDDLLPDHRLVLSNMYDTKGTEVGSIQLLTSQWLEGVVAFFGPDQTCATEARIATAWNLPMISYLCAAEVVSNKEKYGTFARTFPTDKQFSKSVLTLLQHFDWHVVSIVAANQPVFQSMKASLEEVFLSHDITIMNTRDFESPYFGFVMDFMKDTTLADIIQETYQTTRIYIFLGENYELQAFMEELDAKGLIDSGEYLVVTVFKASLKPEQKETFLTAADIKIDSYRPRRVKYFQSVLMLFYTSAMNPDFGTFQERVVYYLQQPPFNVDITHLTEINLGPIIDENAANLYDAVMLYAHALNSTLAAGGDGIRNGSTLISHVVGRSYQSITGLGRTIDANGDANANVSVYTIQKDENSTYGHIIAPVAIFQDYNDTQVYAAHAKAKIDWVGGRPPLAEPKCGFFGKKCPPPEVNHTGKIVAGALSGVGLIIMIILAVWYRNWRYEQELASLIWKIDFDDINMRKNDPFGSRFSLITTDSRGSIFKSQLYTKVGVYKGSVVAIKTLDKKSVDLNRSVRLELKIMRDLCHANLCAFVGACADAPNICIITEYCSRGSLQDILENDDIKLDNMFIASLVSDIIKGMSHLHTSVLHSHGTLKSSNCVVDSRWVLKISDFGLHHFKAGHQNPDMGEHAFYQSFLWKAPELLRDTHAPSEGTQKGDIYSFAIILYELVHRNGPFGNCALTPKEIIDKVKYPLDPTMPFRPNVMEVEDCHECLLTTMQECWHEVPDQRPDFKTIRVKLKPLHSGMKSDILDNMMAIMEKYANNLEEIVEDRTHQLVEEKKKTDNLLHRMLPKPVANQLKRGMQVVPESFDSVTIFFSDIVGFTDLSSRSSPLQVVDLLNDLYTLFDAIISYYDVYKVETIGDAYMLVSGLPIRNGIRHAGEIASTALHLLTAVKEFHIRHKPDEILKLRIGIHSGPVVAAVVGLAMPRYCLFGDTVNTASRMESNGQPLKIHCSGQCRENLVSLEGYDLEERGLVAMKGKGELLTYWLVGQDPSYQRTAPLDAHSDSTENVGALQIQKSPGHGPNAVDLSCFPPSTPDKLNRLSRNNRQVSCPGSDTYGSSERVLGASDPGSDKDGYFLCDVSQNNNRRSPPMDSLQRTDQEGFITDGLEEESTPSDPLLPNITDNPKIMNDAAGRHVGFQKNSIIRSVKDSDGLELGEVNGDRVKKTSVADSGIGSHGTNSRDDALQLEVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALX1</accession>
    <name>A0A914ALX1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064429.1">
        <property type="nucleotide sequence ID" value="XM_038208501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208501.1">
        <property type="protein sequence ID" value="XP_038064429.1"/>
        <property type="gene ID" value="LOC119734883"/>
    </dbReference>
    <dbReference type="GeneID" id="119734883"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000028">
        <property type="entry name" value="caskin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF16">
        <property type="entry name" value="CASKIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="123" mass="14110" checksum="1D449456ECECEB8B" modified="2023-02-22" version="1">MLEYTNNFSKAGYDMPTIARMTPEDLTAIGVTKPGHRKRISAMISQLNEPDGIPNYKPPDVVMWLKLLDLYQYYNTFLSNSYGTMDAVSKITWEDLQEMGINQLGETVVLFSTIRFFIVANFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914API2</accession>
    <name>A0A914API2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein PTHB1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065528.1">
        <property type="nucleotide sequence ID" value="XM_038209600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914API2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209600.1">
        <property type="protein sequence ID" value="XP_038065528.1"/>
        <property type="gene ID" value="LOC119735712"/>
    </dbReference>
    <dbReference type="GeneID" id="119735712"/>
    <dbReference type="CTD" id="27241"/>
    <dbReference type="OMA" id="VPVEDWT"/>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="3">
        <location>
            <begin position="444"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="4">
        <location>
            <begin position="534"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="5">
        <location>
            <begin position="644"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="6">
        <location>
            <begin position="748"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110433" checksum="890E917A361A2B58" modified="2023-02-22" version="1">MSLFKARDWWSHTIGSDDGFDQGSLCVANIDNNSNHHDKVIVGGFNGVLRIYQPRGSQGEANKAEAVLLEMQLPQPILQAEAGRFVSVSEKLHLAVLHPRKLTVYSVSGTAGAVEHGSQYQMKMVYEHNLQRTAFNLVVGPFGSVKGKDFLCVQSMDGTVSFFEQESFSFSRFLPGFLLPGPLRYIPRTDSFVTVSSSWQVESYKYQVLAVATDVKTKEESQKITSGKRITMDWSYSLGEAALDIVVTVSAQGATSIVILGERSIVCLKDTGALKFMKKLEYNPSCFFPHGTSSESSITYMVATHTRQLMIYQDTTLKWAAKLEYVPVSIRVGQFQDLKGVITSIDDQGHLVCSYLGTDPSLFVTPSTDSREINYEEQDLEMKKLQRAIKESASKQDFAPKKTVDEDFQIEVTVPPNLDSTSVYKYFTEGARSATETEVEDDDPIPSITVKLVLKTSVSLPNVRLLIHCPYPISVNQSTFTFPFIGDSSAPTSVLVSFFLRGNSLPASLTASAMATYTTSKGAPRVVRSKIELPLKLVVKPCPPVKTATYKITIDSNKNAANLNDVFPDLLGPSAGGPGQALGFQIIGGPKVTILASKSSQRYRLQSDVFESMWLVIRSFLDRIQSFQRRGGAKDFQLSYGGIVPLTEYFELIDTHLELRINAERYKELLDQRARQFRAIQRRLLTRFKDKTPSPLANLDTLLDGTYRQILKLADGVEENHKALVRCSLGLSCATHMIVTIIKLANNMTDKESEILHSSLMPHVPCDGEQGWEEAVDASISNLLRTCLAKKALDQAVNPTPLIMPSDSTRLKKHISQLCERLSKGARLYMDGQAPEKRSGKSEGVVRPSSSTSRDFSVESTTPDKSKRLDFRKSSQLSGLGDAEPNPSPAPLSNSQPPVSFPPGIEDLPSPGAETNGTLSKEEVPSSPAGGTMLGDLPSLGGPGVRGTSLPPLGAPDGLESPAALPQLKPIKKKKKKKTKSPRNPEPELEPDDNFFGGTGSPEPLSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR08</accession>
    <name>A0A914AR08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066202.1">
        <property type="nucleotide sequence ID" value="XM_038210274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210274.1">
        <property type="protein sequence ID" value="XP_038066202.1"/>
        <property type="gene ID" value="LOC119736237"/>
    </dbReference>
    <dbReference type="GeneID" id="119736237"/>
    <dbReference type="OMA" id="GINNVCV"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="414"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="559"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="666"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110256" checksum="B2045E6854C9CED3" modified="2023-02-22" version="1">MAQRSLFGITREVLKDLLTCRICFEMYDGSTRFAKFLPCMHGFCVVCLAGLARDEPQFKCPECRRDTPVPENGVQGFPDNFIAGQLKDLEHLLDVNVTRPHGLHCGSCISDGGPAVSFCSHADCVTFLCHTCDQAHRTMRKFDDHAVCAIEDLQKQPEILLHRHKIQCELHKHDLTVFCNEEGCQRPLCLVCVPTAHQGHRVVDLDQKSSEVKEELQSLAQAVGEKTAPVKEISERIESEISETRDRKAKMSTKISKMFGELHTKLQNRNDEVISELEKRAEERIQHLRHLGSNARSLVSQFESASQFAERSCEIGNAVDLLGTRGQIISRLHELIAYDINASESFQPAGKAFLSLKSDHNQVLEEFEKLLPSLGCLDACTGGTVTKLMFTIDFPDDVGSTLPVKATHKVRISSVDPSSPSLESLSGCLGAYLQSPDGSTVECVNGEQCGEFYELQFRPLVAGPHQLNISVSGVPITGSPFPVVVVDTTSSPVDDGQAEQSQDEVCSDLTWTDAFVQCEHKITVKFQAPEHRLPRVNNLSAWYSMPWNQDQEDTGYAIPDKLTASNETEAQIVETNDSQTFRIVYTPPDAGKLIMSVFMNGQPIANSPFVINVNPLHPDSTIVSSHQLGKCQPNTAVLDMPFKLTLLTCDHHGERLTTGGYNITASVTISGSSESLQRHCFTDNRDGSHTVTITPRSVKLHFVSITICGNPVKSPLEISVVDSLPFEDPPTGFEKPTGLDVDTNSHTVYVVDMKKGGRVCMFESDDGSFMSEWAIGESLCKKSSQIAVNNARQLVLLVSDLKLVLTYNIQGSIVSKWKCATDNRKPANLALSREGHVIVGDSQSQELFIYQPKSEVMGRIQLPEGALARGINNVCVDHNQNLLVVTHSEPNRILRYTMTGALISILESPTESCQLAVASTPEGALIVSMLHGILVLEFSHDLMEVAKVKEFRTDYIYTKLAVVTDGCFVAFDPGAKHLAKYSYQPKPSARRREVDEGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS61</accession>
    <name>A0A914AS61_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066493.1">
        <property type="nucleotide sequence ID" value="XM_038210565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210565.1">
        <property type="protein sequence ID" value="XP_038066493.1"/>
        <property type="gene ID" value="LOC119736551"/>
    </dbReference>
    <dbReference type="GeneID" id="119736551"/>
    <dbReference type="OMA" id="DSSCHEK"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="150" mass="16550" checksum="ED8EC8A743F5DFDD" modified="2023-02-22" version="1">MEDGRISDASITASSVLFNSAKYLPTRARLETLAGAWCNNGSSDANPWIQVDLGSHVTITGVITQGHGEGYTQWVTEFKVAYSDDGQEWTDVTDDGSSTPKKFPRNSDGDTHVTTTFPGAFQARFLRILPTQWNVYCCMRFEVLGCTNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASG8</accession>
    <name>A0A914ASG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066712.1">
        <property type="nucleotide sequence ID" value="XM_038210784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066752.1">
        <property type="nucleotide sequence ID" value="XM_038210824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210784.1">
        <property type="protein sequence ID" value="XP_038066712.1"/>
        <property type="gene ID" value="LOC119736773"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210824.1">
        <property type="protein sequence ID" value="XP_038066752.1"/>
        <property type="gene ID" value="LOC119736814"/>
    </dbReference>
    <dbReference type="GeneID" id="119736773"/>
    <dbReference type="GeneID" id="119736814"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275708" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="51"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="181" mass="19895" checksum="469CC6F91B07F8C6" modified="2023-02-22" version="1">MAFWSEFIVIVAVISSIKAVFGSGLGPSRLSVKCHSRLIVECSCPPKWQLWGKACYLLSETPATWDDSQSDCQAMGGKMAAPRSQEEMTLMVELARNVDLKFYAWIACDDKVVEGSWDCDGQEGSEPFLAWHQGEPNNSESQQDCAQIGQGGMDDVSCDLSSRAFCARQAACIHGLTHIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASL9</accession>
    <name>A0A914ASL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067055.1">
        <property type="nucleotide sequence ID" value="XM_038211127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211127.1">
        <property type="protein sequence ID" value="XP_038067055.1"/>
        <property type="gene ID" value="LOC119737055"/>
    </dbReference>
    <dbReference type="GeneID" id="119737055"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000232">
        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000926">
        <property type="entry name" value="Kruppel like factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF174">
        <property type="entry name" value="CABUT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="31377" checksum="5843E31D558BCFE2" modified="2023-02-22" version="1">MDTTTILPNQQTSFDYGQTDMDVTSAAECLLAIAKSRPPWKSPVIAPTPLPAELGYTTPPYDDGMTQDSELAALPNPLFMVARILADLETYKNRDLAPSPISDCSSSLELSQDPFASIPPPGVKSKGGKKRRARKSSTCDDTLATGQRSKRGGSKRSDRGPDGQPVKKHKCHYIGCDKMYGKSSHLKAHLRTHTGERPFPCTWPDCNKRFARSDELARHYRTHTGEKRFCCPLCEKRFMRSDHLMKHARRHANFHPSLLKRPRSLADSLSDRSANSSPVNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASQ4</accession>
    <name>A0A914ASQ4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066499.1">
        <property type="nucleotide sequence ID" value="XM_038210571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210571.1">
        <property type="protein sequence ID" value="XP_038066499.1"/>
        <property type="gene ID" value="LOC119736558"/>
    </dbReference>
    <dbReference type="GeneID" id="119736558"/>
    <dbReference type="OMA" id="CRCETEP"/>
    <dbReference type="OrthoDB" id="6104570at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038068716" evidence="1">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="31388" checksum="3C3E1A6DDA7B5F0B" modified="2023-02-22" version="1">MEYKVYANIFVVVLFSLQFKEEVAALCGSPTSRTLVIIADGIHGQSCNLLGVSDEFVVESCKSFGAACSLERQDLPQVPSPELQVNKLKLDLSGFGNEYRFPDLSRAAFYLKIFGTFRHRYISLVCHKCDTHLVRQLRITPDTMIMRNIFQESFNSYRTKREPKISDSEAFNIQCNQRLGEVKLSYRRENVLYIQEENLVVTVEGDAVRSLNFNLGFEVNMGLRGLECMGTFINDIVTADSQSALVRAMSDKTRFSHQVNREVIHSRLYNTLGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXE3</accession>
    <name>A0A914AXE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068363.1">
        <property type="nucleotide sequence ID" value="XM_038212435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212435.1">
        <property type="protein sequence ID" value="XP_038068363.1"/>
        <property type="gene ID" value="LOC119737820"/>
    </dbReference>
    <dbReference type="GeneID" id="119737820"/>
    <dbReference type="OMA" id="KTWENPD"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63043" checksum="7DFC7E9626D70735" modified="2023-02-22" version="1">TGRSNSRRSLFGRLLLEFVSYESTRTCTCIDTYTSCKSAVPYVMDFLDVRTVLLGVFLLLVLRWLLGRPKNLPPGPWGFPLLGSVPAMVWCMLRGLEFHHQFEKYAAKYGPIFRIKIFNKTVVVLNDYALVKEAFQHPQLSNRPKSLFTEVLKLEGVAASNGEAWLELRRFCLTVLRSFGVGKSSFEEQIGTEAEELMKELAAFKGKPFNPKPFLGNAVSNVICSVIFGKRYKYDDKEFMHLLDLMSRNIKLVGGGGAITFIPSLRYLPFLPIPELLSNFEELLNFARNVIDTHRKTFDADNLKDFTDAYLMEIQQNLSRDKEGMLPNGKHLKASKFGHLGERNIVGTILDLFAAGSETTATTLQWAVLYMMVNPDVQKRVQAEIDDVVGRNRMPRMADIPELHFTRAVIWEIQRLANIVPLGVPHAAASDIYLRGFFIPKDALLVPNMWTIFRDPKHWPEPEQFKPERFLNEKGVAVKPEELIPFSTGRRSCIGEHLAKMELFLFFSFFMHQFTFKKPQNSPPLALKGKGGITHSPQPYDLCAISREDFGGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXF2</accession>
    <name>A0A914AXF2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068204.1">
        <property type="nucleotide sequence ID" value="XM_038212276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212276.1">
        <property type="protein sequence ID" value="XP_038068204.1"/>
        <property type="gene ID" value="LOC119737723"/>
    </dbReference>
    <dbReference type="GeneID" id="119737723"/>
    <dbReference type="CTD" id="91300"/>
    <dbReference type="OMA" id="CQYMSLL"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="31287" checksum="B9176D2DFA73AA5C" modified="2023-02-22" version="1">MGITKEEEDNVLPEQSELIVPESVETKPPVSPRRQRQRRSRHCCPTVSPKSAGHKTGGHKRTRRYENTCFLLSLVDEADFGEVSISDFVESSQSVFEQLLSDRDSLEIWNDFMNRPEDEQEIFLQQVATKEVPKKETGKQEKEAGTAVDKKDNKDDDKRTVHPAHTPEESFQRINSRLRTMLRRKHLPKGMLQNHEDDLVPWFTDDPGAVFISHINCSFDRLLMHAVCQYLDLQSISYDCDGRRQTKVENGQDYFSPPKLLLSQYLDSLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYB8</accession>
    <name>A0A914AYB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069140.1">
        <property type="nucleotide sequence ID" value="XM_038213212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213212.1">
        <property type="protein sequence ID" value="XP_038069140.1"/>
        <property type="gene ID" value="LOC119738350"/>
    </dbReference>
    <dbReference type="GeneID" id="119738350"/>
    <dbReference type="OMA" id="KRSHECE"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="43569" checksum="CDFE2978F842B55F" modified="2023-02-22" version="1">MEKKGQGGVNQLGGMFANGRPLPMYIRNRILELAHLGLRPCDISRQLLVSHGCVSKILSRFAETGSILPGAIGGSKPRVSTPSVVSSIARYKEINSSMFAWEIRERLLADGVCTEENLPSVSSINRILRNVCRDGPEGDPAPTGSEAGEAGDRWGRRLPSPGCTKKDTSVKTEVRDDPKSSPGQARHSTSFAMDDILGTRGKKRSHECENGTPVVRGEDSGVDRIRKDTKRQRKSKKVHTESQHHGCGYQPLSIRDEWQRVTMTSSTALNDKIEHSPEVPAMLPAFLPAFPAFPHPMDASSHLWNLALFRSFAFAQAQQASIQANPKALRAHQHHASLVLSGHGAPSAVVSNRLPFLPPHPIKRPVPPAMAGHHYDVTGGSIPGFSALRFKTAHIKNEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0C8</accession>
    <name>A0A914B0C8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069432.1">
        <property type="nucleotide sequence ID" value="XM_038213504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0C8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213504.1">
        <property type="protein sequence ID" value="XP_038069432.1"/>
        <property type="gene ID" value="LOC119738598"/>
    </dbReference>
    <dbReference type="GeneID" id="119738598"/>
    <dbReference type="OMA" id="RACINTE"/>
    <dbReference type="OrthoDB" id="6123456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="10">
        <location>
            <begin position="516"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="10">
        <location>
            <begin position="569"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="839" mass="95482" checksum="772BC5D4D63A9A95" modified="2023-02-22" version="1">MRASEKARIAFKKMCVQQVKEEGKKVRNEKEGDQGAEVAGVLDGDPTIPKLESFRWAGLIDEARAKMPLLVSAVEASLSPKLKQKQPDRKDSVRDKRLGIILAVIFYTRVPRKYNFVQGAIGVELWRQGCSKKLFQALNHLGISLGRQTSRQHVDQLATDQDNCLVKWKSAVQTTYGSRYWKTGRRRSSFKQDPGYGVCWDNVQINPHRKLQGKQKKAECLSWALAFACGNRIPTLHLKDPSTIPASQLISSILPRPADYDELRKLMVSLVMRILVKYLPFMQSMKKHLPRPKHQYSAEMTRKSEVVNLGVLEVNPATTAGVVRVMEHLHAYVPEPDGQLCPILCSGDGLSVDRMTRAKRASINKESKKQQLQGLVECPQESHKEKLLLQDTMNNLYKGSSVASRGSLAHLKEFYRHRCMANDAKQDIQHIWDTIEFCTEAYVTLFAMTAANMETVNDVPLNFPVNGNMADKTDFVWKIAGAAVDFCWSATKSEDIRKVYASTKSSASTPGEPYGFCCCGKETDEAMIQCFSHQCPHVWYHLSCVGLDEPPAVEWYCSKKCDGDGTYIYCMCHQRKGGEMVQCALKQDCRRHEWYHWSCLSDTTFPDLWFCCDDCALGSEGDDSVQNYTKALMWRGLNHLARRWAVRHGDGKTMTSHWKMDLIEFWAFGHDKYLTMAQQFLTGVSGFLPERLRHDITWNRVANVHGMEGENIGLDLLNKFLNNEFKDMLLRSRRKYTQQQAQRCSQMSGELGKQIDQLLTGGLGDLPSKNSSEKTVNKDVLDFVSEFKKDALFDYVPGRHHQGFEDYTYDTSIEAPDCLGQRLLVTSQEMDRWNEIMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B183</accession>
    <name>A0A914B183_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069549.1">
        <property type="nucleotide sequence ID" value="XM_038213621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B183"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213621.1">
        <property type="protein sequence ID" value="XP_038069549.1"/>
        <property type="gene ID" value="LOC119738693"/>
    </dbReference>
    <dbReference type="GeneID" id="119738693"/>
    <dbReference type="OMA" id="SCMEVTT"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="647" mass="72802" checksum="D13B171E4F1EB4A6" modified="2023-02-22" version="1">MAAAWLPFARAAAIGWVPIAPNAMPVAPERHTAATEGGRIVLNISGRRYETWRHMLEKYPDTLLGSNEKEFFFDEDSGEYFFDRDPDLFRHVLAFYRTGRMHLPREECINSFDEELAFFGVMPEIIGDCCYEEYRDRKRENAERLMDERSSEMGDCPDLHTMREKMWRAFENPHTGTWALVFYYVTGFFIAVSVFANVVETIPCPPFPGTVEHVACGDRYHDAFFCLDTACVLIFTVEYILRAYAAPDRCKFMRSVMCVIDVVAIMPYYIGLMFNSDSLSGMFTTLRVFRVVRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMFYAEKSVEKTKFFSIPAAFWYTIVTMTTLGYGDIVPNTVIGKIVGGVCALSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRLAKNASGNAFVTRKKEADRLAESGCSLEDLTSKYSAYESQHHHLLSCLEKTTTWYDGPSEADEPMVRTDQSADFTQRQYQETEYTYNGIPFTRPLDTGSPPLTPSHSHESALHNPGRNHAESSASTCCTRWARGNRYQATPTSPDDSDLNEVHVHDPNANPAITKEDLSLDPYPKMNCTTTVTEAIVTMMPPSVAGDGDSLNTTVSTRSSPGVVRVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5G8</accession>
    <name>A0A914B5G8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038071485.1">
        <property type="nucleotide sequence ID" value="XM_038215557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071486.1">
        <property type="nucleotide sequence ID" value="XM_038215558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5G8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215557.1">
        <property type="protein sequence ID" value="XP_038071485.1"/>
        <property type="gene ID" value="LOC119740293"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215558.1">
        <property type="protein sequence ID" value="XP_038071486.1"/>
        <property type="gene ID" value="LOC119740293"/>
    </dbReference>
    <dbReference type="GeneID" id="119740293"/>
    <dbReference type="CTD" id="9488"/>
    <dbReference type="OMA" id="HHMVFNN"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="598" mass="68775" checksum="6C2C19932A0864B2" modified="2023-02-22" version="1">MQTQSTNDVMAHNLRSRQVPAQPSDEPEADPPPTSVHDSAHRLQSLRKRVTFRSVNQDENNTDSTPMTDSPKPVLAKEKVPPEDLKPWPRSRMLIVLILFRWVNAVLTQTFFAPDEYWQSLEVAHNIVFGYGYLTWEWRTGLRGFTHPIIFAVLYKTLQVLNIDHPMLLVLLPKILQATFSAIGDYHLYKFSHCLWGESVARWTLFCHLSSWFVFYTAARTLTNTMEMILTVCAMYYYPWPSSMIKGVDPSQHRYSTGLYLLLAALACIMRPTAAIIWIPLCAWHLVRCRNLILALLVDFIPIGSAALSCSLLMDRICYGRWVFVHFNFLRVNTVYNISSFYGTQPWHWYLTQGLPVIIGTHVFPFILGIRLAGRAYRPLVLLMVWTQFVYSLLQHKEYRFLLPLVPIAMSFCGVSLCKLSKSGRATSMAMFILASNLPICLYTGLIHQRGTLDVMGYIQTIGHAPDVHIRVPSVLFLMPCHSTPFFSHVHANISMRFLECPPNLGRYRTEEATYQDEADVFFENPSDWLKTEFRPGSNLPRYLVFYDVLLPKIKRFLTSRGYSKTASFFHTHVPLESRIGRHVLVYSRPLKIPLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B670</accession>
    <name>A0A914B670_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071720.1">
        <property type="nucleotide sequence ID" value="XM_038215792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071721.1">
        <property type="nucleotide sequence ID" value="XM_038215793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071722.1">
        <property type="nucleotide sequence ID" value="XM_038215794.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215792.1">
        <property type="protein sequence ID" value="XP_038071720.1"/>
        <property type="gene ID" value="LOC119740468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215793.1">
        <property type="protein sequence ID" value="XP_038071721.1"/>
        <property type="gene ID" value="LOC119740468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215794.1">
        <property type="protein sequence ID" value="XP_038071722.1"/>
        <property type="gene ID" value="LOC119740468"/>
    </dbReference>
    <dbReference type="GeneID" id="119740468"/>
    <dbReference type="CTD" id="64800"/>
    <dbReference type="OMA" id="NLCEKRS"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000243">
        <property type="entry name" value="EF-hand calcium binding domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000121">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000179">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015070">
        <property type="entry name" value="EF_hand_DJBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08976">
        <property type="entry name" value="EF-hand_11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="921"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1364"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1479"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1546" mass="179241" checksum="61D035A4B9B096BB" modified="2023-02-22" version="1">MASPLVIGSGMGGLRPATSGVMFTPRDILKTSNGLRTPGSRASRGSFEYGRIEERVPSRASSAPLTNTVLTANPQLSVIEVEQLIREKVRQHYHDLKQACQNYDIDQSLTITKGELRRVLDMYCQPLTREQFDAVVAKVPVSANGTVNYCNFLDRFASSGEGSRESWKMTSGHRYSYTKSPQDMGIDVLERQLREKVAANLKNFLKGLQLFDYNRDGKVQKHELRKVIENYCFRMSDEQYDRLWSRYDFHHNGVVNYKEFLQRLGVNVKRHDVMFPESTKPLSFSEREQNRAKQVEQLAVFNGSDDSVRGMTFPQIEAELRKRLKENYVNLKKMFMAFDARQDGFVSLDDLKSILIQFTLPMSDQLFAQLMDRFGLKASHKIPWEHFLEKFQNPRIEGNGQTLPIKPNHKVNPIREGDSEMEVEDILELLHKHVTNMYPSIKEAFLAFDQNRDGKVTRKELRKILDKFTIRLNEQQFKGLVAKLDPNNANNINYHTFLDLFEVRETKEGHKWLDSEHRWNDRAPANLAWSTVEDILREKIEEYWKSVSSAYRLADPESTGAIGYKSLKKILNRHVLPVSDEHFDVLWSQCEESPDGKILFAEFLQKLGVDVSPGDLVGPSTRIQVLSDLSEQQRQADLDIRLTNVQLNALERTSQMPADEVMVKLKDRMAQKSGRIRENFLRYCKNRRGKLYKKEFKEVLKSFGMYMSDEQFSKLCEVIGFNRGPLTYSDFVEQFEDPRVGGPGEEITRVPNHRYTELPLYNMTAEEVEGQLMDKMRQAFGSLRTTFYKLDDNHDGLVEQDDFRRLMDALMFTISDEEFKRLMSKLAINKRTKLSYKDFLERFQVVDAPGSHKWLDSDHRFNKTIDPVQLAADQVHDILVTKAQRQYQDLAKAFMSIDKNGNGVITKKELRDLLYTFMLPMTKEEFEVLWKKYDVNSKGYIDHQHFLRMMGKSFAPGDDAGVSRRIVEDSYEALEDHHINQMDKQMSITVNQASNATFISASQLEQGLKDRFRDRYASFQTAFNQLDLSKTGYITVKELKRVLLDHNYLVDDDTFAEFLQRIGVQSERGKLSYIQFLDAFDEARESRYRQKNHPVVRPESFSLLGPDKAMKKLKRMMSTQLPVLRAAFGAFDKDKSGRITAPQLRRVLDNFCFKLTDKQFKHLMSKIRVNSDLTLSYMTFLEEFSTNENEIANNWFDSLNKVEEDTSQSPPLYTLEDLQRDLRETVSARFYRFAERFAEIDYAKIGVVCKEDFKMVMDEIGFRMNPDQFDSLWNTLPVNEFGNVEYRRFLKLYMVDNLDVSKFDSLSEMPRAGSVHPVRQIYTSPASRTPSKMSGRLTGQQSRLATPLVNAHGAEQRLKSQIGKQWKDVQRLCRQKDPDSTGQVNAEDFKAILEGLGFSLFGEEFDQLTTKYDLKGNGKFAYLDFLKHFVLKLQPVAEEGDRTLTSRQRIHPSKIPTKPGSSSTDMIEAMLRVRECILDNWKQMRRVFRGIDPTGTGIVTAAEFRSVLRQFNINLSEDEFFHLMTYYDRCLEGKISYNDFLRAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6N8</accession>
    <name>A0A914B6N8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071788.1">
        <property type="nucleotide sequence ID" value="XM_038215860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6N8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215860.1">
        <property type="protein sequence ID" value="XP_038071788.1"/>
        <property type="gene ID" value="LOC119740518"/>
    </dbReference>
    <dbReference type="GeneID" id="119740518"/>
    <dbReference type="OMA" id="FGGSWDC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037723653" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="154" mass="16956" checksum="E7A9736649EE0F67" modified="2023-02-22" version="1">MKRFAIAALLLSALATLTSPCLGFCIPPFGWHSKSLVERMELGEAEVVVLATVDATSPAHPYKYPYTADLIVDCVYKDTSGESERLPDYLKDVEGFGGSWDCAETRVEAGTQYIIFLNRRGPYAAEVAEVNSQSGAEQAIPTRLKKVEEKYQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA15</accession>
    <name>A0A914BA15_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072676.1">
        <property type="nucleotide sequence ID" value="XM_038216748.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072677.1">
        <property type="nucleotide sequence ID" value="XM_038216749.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072679.1">
        <property type="nucleotide sequence ID" value="XM_038216751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072680.1">
        <property type="nucleotide sequence ID" value="XM_038216752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216748.1">
        <property type="protein sequence ID" value="XP_038072676.1"/>
        <property type="gene ID" value="LOC119741083"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216749.1">
        <property type="protein sequence ID" value="XP_038072677.1"/>
        <property type="gene ID" value="LOC119741083"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216751.1">
        <property type="protein sequence ID" value="XP_038072679.1"/>
        <property type="gene ID" value="LOC119741083"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216752.1">
        <property type="protein sequence ID" value="XP_038072680.1"/>
        <property type="gene ID" value="LOC119741083"/>
    </dbReference>
    <dbReference type="GeneID" id="119741083"/>
    <dbReference type="OMA" id="VYRLEMH"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005428">
        <property type="entry name" value="CD36/SCARB1/SNMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01610">
        <property type="entry name" value="CD36ANTIGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="524" mass="59483" checksum="04D2BAD59A82C674" modified="2023-02-22" version="1">MTGYKGQLVCVVTGTLLVITGAVLIPVVWNAVKHSLMTKIMVLEPSSMIYSIWEEPPFIIYWRFYFFDVENAEEVVKGAKPSVVQRGPYVYRLEMERQNLTVNSNSTISNKPVYSYFFEPDMSVGLESDSFTAVNVPYATATHLLDWLPYDIKIALSLVLDEMHEHLFKELTVKELLWGYEDEVLKILSKFIKIPGMPNGEFGFLVDQNGSAHDDFTVFSGKDVRSRINLIERWNGNNKLSWWLTPEANMINGTDGVMFHSFVTEKDTLYLFQPNLCRSMPYVFDRAKTIRGVPVSSFYLPPNVYQNGSVYPPNAGFCDVKTEDCGPTGQMRVDKCRFGVPTSISNPHFLYGDRSLIDGVNGLAPDPNEHKNYLSVQPILGVTFELKFRLQLNLYLEKVAGFSDIEKIIPVYFPMLWFEQSFEANDWMVNTYNSKVGVPTLVCQIAEYALMGLGVAIMLLSLVVIVRKYRRKRSDETEPLLSDANPSTNYTAEEDTSNHSTNYMPEGEDAEILPTNHQELAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAD6</accession>
    <name>A0A914BAD6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072969.1">
        <property type="nucleotide sequence ID" value="XM_038217041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAD6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217041.1">
        <property type="protein sequence ID" value="XP_038072969.1"/>
        <property type="gene ID" value="LOC119741289"/>
    </dbReference>
    <dbReference type="GeneID" id="119741289"/>
    <dbReference type="OMA" id="DPNAYCV"/>
    <dbReference type="OrthoDB" id="10060424at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="606"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="679" mass="73943" checksum="CAA3C7864AA9D1B6" modified="2023-02-22" version="1">MAVFFSPDYKKDVDECTLGTANCPQDRQCKNTYSNYMRLCPVGYKFAYVNGKLDCVDENECGNNRCDPNAYCVNVVGGFQCRCNDGFQGDGNKCVPIDTTTCLDKPCFQDVECSDVPISAERELPAEGVTSIKQYQCGPCPPTFVGDDENECGNNRCDPNAYCVNVVGGFQCRCNDGFQGDGNKCVPIDTTTCLDKPCFQDVECTDMPVSAERELPREGVTSIKQYQCGPCPPTFVGDGETCNPSTISVMIVVVDKGEGDLPLSEVSVKAQVERSDGQTVIIAEATTDLNGLATLQVPSGITLQLVATKDRFVHSIKSYFVQPEGGNVVPIPMKSFDEYAAFRYNKDTSKYFEFGNIDEDKSGFRLSLPEGALRARDRTLVEVNYKGVDVSSPDALAALPDLGKVEGEPGQRLIPLGAAELSLLDEQGRRVNLRRPASMTFLLKDYMYMYMEQLGVGETLAAYYFDEEQGKWIKDGTGTIRDSVDGPAWTYDTDHFTWWIVAVMYTPTKCLKVRTCYDAGCTRPAAQIPIIIYGENFFLYEEYTTGASGSICANVLSDRMSQVGVLQNCTGESQLVTASTARDAQCGDGSNGCEVVTFIIPEGVSGVCPNPGEPLNGVRSGNSFGLGDQVSFFCDPAYRVNGNSQRVCQQCGRWSGFQPFCTLANEGSDSSFGSGDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDC1</accession>
    <name>A0A914BDC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073840.1">
        <property type="nucleotide sequence ID" value="XM_038217912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217912.1">
        <property type="protein sequence ID" value="XP_038073840.1"/>
        <property type="gene ID" value="LOC119741947"/>
    </dbReference>
    <dbReference type="GeneID" id="119741947"/>
    <dbReference type="CTD" id="65003"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000003">
        <property type="entry name" value="39S ribosomal protein L11, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="13">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="12">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="211" mass="23120" checksum="A7FC1BEE47C6F7E9" modified="2023-02-22" version="1">MDGGHLSSKTSTNQLAVTSDKMSKAARAIKSAKDAAKKVEHGNKIRSYIKAGRAAPGPPLGPVLGQRGIAIGQFCKDFNEKTKHIKDGVPLPCYIHINPDRSYDIEIRTPPVSYLVKQAAGMNRGVHEAGKQIFGKISLKHVYEIAKIKHEDAPLRDLSLQDVCKQIIGSCRSMGVQVVRTLDSEDYGEFLEEVAETRKALDAQRALDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEH3</accession>
    <name>A0A914BEH3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074270.1">
        <property type="nucleotide sequence ID" value="XM_038218342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218342.1">
        <property type="protein sequence ID" value="XP_038074270.1"/>
        <property type="gene ID" value="LOC119742425"/>
    </dbReference>
    <dbReference type="GeneID" id="119742425"/>
    <dbReference type="OMA" id="KARMQNV"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="68"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="297"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="519" mass="57300" checksum="CAF2B8CC0620CD23" modified="2023-02-22" version="1">MDIVRSRSPGITGHQHRRYAVEEADTFNTSVEEIFWPAMPAGSINTPLVANAYGENVPAPDEHDLGRRSSFGMSVFNLMNAILGSGILGLSFAMAKSGIVLFTFLLVTVAVLADFSIHLLLKMCVLTGVKSYEEVGLFAFKIPGKIMAASAILLQNIGAMSSYLFIVKDELPKILSTFLSDIEDKSIWYLNGTYLVLMVVVIIIVPLACLPKIGFLGYTSGLSILCMVFFTVVIVIKQFSFPCPIPDMIWTNMTSSDRINTTTAQYSSSDDTESPIGYKSQLDEDSANHSTSSECQPKYFSLTTETAYALPTMAFSFVCHTAVLPVYCELSKPSKSRMQNVANTSIFISFTLYMVSALFGYLTFYGNVSDELLDGYELFNPSDRIILIVRVAVCLAIIFTIPLIHYPARKSLLMIFSTWVPLRDASYPWLRHFVSTAVLITLVTCIAVFVPNIKQIFGIVGATASTSLVFILPSLFYLRLGTERLKSPQKIACMGLLFIGVTTLIISLTTIIYRIVTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGP3</accession>
    <name>A0A914BGP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bromodomain adjacent to zinc finger domain protein 1A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075264.1">
        <property type="nucleotide sequence ID" value="XM_038219336.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219336.1">
        <property type="protein sequence ID" value="XP_038075264.1"/>
        <property type="gene ID" value="LOC119743024"/>
    </dbReference>
    <dbReference type="GeneID" id="119743024"/>
    <dbReference type="CTD" id="11177"/>
    <dbReference type="OMA" id="FERQCEE"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15539">
        <property type="entry name" value="PHD1_AIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15627">
        <property type="entry name" value="PHD_BAZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000300">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="20">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="19">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="1263"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="1413"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="1475"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="1730"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="696"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1118"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1193"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1313"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1527"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1821"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1139"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1200"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1318"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1332"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1534"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1556"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1574"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1607"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1689"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1825"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1846" mass="211064" checksum="1CC8B592ECA815CB" modified="2023-02-22" version="1">MPLLRRREFKPIKPPPDLRPNEEVFVCRLTNELFRDYNEFFKRTILCNSLVWSCSLTGKPGLTYQEAVESEAKARRYLASFPVYLEAPILYLVTLTQRGRLADLCDDVFVFSRDRYFIGEIVDVSHKGTRETCRVVGVIPPVGSSELTNGEASDSDDVIIIEDDGQEKVLKMGEPKTSNRTGPPQTLEANEYRYKVMSLQGNGTYQVDYRNIGRKKGLYTREKNKLFLKQHCAIVNHVWCVKREYKTKYNLAQKHFHNFYGGPPPLFAFSPGKRTWKCSTELESSEDEDDDIPLCEVKKKAQANQIKENRPETKAKQKTSPPAEPKKPKMTLEEREAIREQMRQEKLLIKEQLLMERARAKELIRLQKLEEKEARKEQMRKLMEEDRLKKMREREVLREEKRLQDEHWREFNRTRDDLECDDLKELPWPSPVNMKLPQELFGDVVMVLEFMYHFKEYLGFSEEFPDGIILDQIEDALLTNKVDGMYYDLVNSLLSAIFRMQEEEEEDEKFDLKEEQRHAPSADLAEALCEDDPTYAAMTKAATSALVWPQIHQGTPLRQLPIDSTTISEVLRLHFLSSGARTTSENTKWRYQQRXGFIPHDDPGLEFRMQDPDILKTLTTGNMFDLPPSSKTKILTSLCGQLLTYVTMRDIIEESLETFQTSRKEWRELVRLEHRREREDGTAKWKRRLEERALEKEHERLKREQRDREREAQLRQDQQAGAGEEIINLDSSSETEDMDQTSESVQKNGPKTEDALELMDLEQRLENLKPLPTQEELDARQRREEEENAALKAEFNKRNREYRLEMAEAAMRYSITPLGEDRIYRRFWLFSAVPGLFVEHDLSHLVDVDLNPVPQRVDCKPQIPDVGLPQVKPENLEGDKDQDTSTSSNKENIDVEAVNGAMETETTAQQQERLVKEPLLVNGVIQEAEPKQEPDPCMMHKQHTRWSYYSTPQELESLMASLNRRGFREKSLKEAILYEKMRIEDSLQAVPTKALNSTNKEEGAEGEELEKDSKQGGVSRQVVVKMNSGKKGLVSDKANGDEALELLLREQILDIEERVWNGSLGIIKVEQRGEWITAIEQGSYIRQCQQISWGPLYARSFLDDKDFLNMSMPDLPKLEDEGASAQTRKHSRLAELQRSDATGSPSSTRCSTPMTPMDNVVRDLTCALLQVSQGIDAKYLKAPLGSEDTGRYAAIRKSKRMQEKLEGKKEESEDEDEDADKKPRKTCRECWEESLMAATSLPQIFLHLSTLERSIIWSKSILNARCRICRRKGDAEQMLLCDGCDRGLHMYCLKPRLKKVPQGEWYCKDCTPKERSPRKQRRTMMQKRKQEEEEEEEEEDSSEEEEEEEEGEEEEEQASSDEEDENEEDSDVEDEEEEDEEEEEEEEEDEEEVSEEEASDAEMESDEEDIDHLDTCEGCGHGGQMVLCHKCPCAYHIECLQPPLHKPPRAKWLCPICSVKRIPNGATGSDADAHEDTCATCGHGGELICCDTCPKAFHMECCKPALSRIPKGQWSCEVCKKAKRSGKNQRAGKSMESPASTSKSSSKESTPKGGASSKNSTPKSATPKDSASRGSSSKNPPKSASKGGKTQAKTTGSKSKAGSSASKKPEASKKREATKKPETSKADAKTSRSHEEGRGRSSRRQSTDSRSSTPDAEAGKLNMMKGVKVVLTAINGGSRRQQRSRSQSLDDSASEDSGPSSVYRRQSSSGRGSKEMRKIHHCEELLKELVKHPESVPFLSAVSKKAVPDYYKIIKRPMDFASMQTKVNAMEYRTATEFVADVQLIFTNCQQYNQPWSATYKSGTKLRAFFEKRLKALGISVPTSREAKGKDVPTEEQPPKKRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ49</accession>
    <name>A0A914BJ49_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075856.1">
        <property type="nucleotide sequence ID" value="XM_038219928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ49"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219928.1">
        <property type="protein sequence ID" value="XP_038075856.1"/>
        <property type="gene ID" value="LOC119743505"/>
    </dbReference>
    <dbReference type="GeneID" id="119743505"/>
    <dbReference type="OrthoDB" id="6081075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="106" mass="11934" checksum="7578091AA3602C1B" modified="2023-02-22" version="1">MPVKVDELDYRREKKMPRKPGPTPEHFTPSKMIKATSIANIQDHLKKVCEESHSGALFLTLANDPPVAQSPVLVPSVKDLYQQYQASSQDGSFVDYFAANTTWLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJI8</accession>
    <name>A0A914BJI8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076269.1">
        <property type="nucleotide sequence ID" value="XM_038220341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJI8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220341.1">
        <property type="protein sequence ID" value="XP_038076269.1"/>
        <property type="gene ID" value="LOC119744414"/>
    </dbReference>
    <dbReference type="GeneID" id="119744414"/>
    <dbReference type="CTD" id="55815"/>
    <dbReference type="OMA" id="EWGYNLH"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF0">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="771" mass="88901" checksum="829DBD99F67730AC" modified="2023-02-22" version="1">MTTKAVALAKLPPIGSTQQTAGVGISPRAVRQYEGLQGPSYQLNSVSDRTKHKLPQPQVLRPFVDTKAGTLDTWPAHATAQATAKPGIPSHRPRSSPDGRMSSELSEDPQRSVIPKPRFLEQLEMFLKKELRNLDGNKEGPGELRLQAYREVFEYLIEDFKTYKPLLSSIKTEYEMMLSNQREQIRELEPLKSMLVTVSEQCDQKVMALREEERQEMLDLKKDKKMLQEKIDAMKQHEVSLQMQIDKLQEDVAAEYYKYRNECDARKLLVSDINDLRYQQEDYQKSQGQVSQAGETKEDPVKLKIALRKAREDLTDATQRLTEMIANYGDVVPRRDYEGLKVQHEKLQEEIAQLKDDHEILMSEHDTLLEVNKQVVTQRDEFYSELEILKRSATPRPDWDRCADFMEGGEERWKTISKDKSSDNKVELLLKELAGDGEGLAFFEPRGFGENVPVYLQTDIKVRNREYTKGEALELIKEIWKAKNKRESEKENASTEPMDTFVARFLDERYRDKKMIAEKAYNLHDACERYRDMEGMCELFYQVLTDEVIEQVYNQEMEMLEQLMEALNKASETIEVPSTTPAPAETEPAAEAQEGEEPPTEEADKEEMPQLTTIQVISRENFEAALREVFTVKPDENIEALMTTLMEDLKPEEGAETLKYQDLFLEDEDGGARPFINLIRQQDKEERLKYVEQIKLELGDREEVPLPELRMAINVVDAEIDKNHMIEYLARSYDVPNDQLNTATPQAVETVIQRLLKAGVRRIGLLNSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJT9</accession>
    <name>A0A914BJT9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076081.1">
        <property type="nucleotide sequence ID" value="XM_038220153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJT9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220153.1">
        <property type="protein sequence ID" value="XP_038076081.1"/>
        <property type="gene ID" value="LOC119744283"/>
    </dbReference>
    <dbReference type="GeneID" id="119744283"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036895153" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="139" mass="14869" checksum="0F75B81A9DBC1781" modified="2023-02-22" version="1">MLLFLLIAGFASAIQSVSGIECYMCHGIIARAPICGTYCDDVVDVNKCGEALDLTQPQNTTTCDGVCQTKSTYHMDEKIYVDRSCVPKCEEDCFLTFGTGACFSCCDSNHCNAANGKAASVWLLGMAAIATTAALKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKH9</accession>
    <name>A0A914BKH9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076614.1">
        <property type="nucleotide sequence ID" value="XM_038220686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKH9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220686.1">
        <property type="protein sequence ID" value="XP_038076614.1"/>
        <property type="gene ID" value="LOC119744639"/>
    </dbReference>
    <dbReference type="GeneID" id="119744639"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="18920" checksum="A354387E04F5EACF" modified="2023-02-22" version="1">MSTRTLSGTTVDPESRAQLEAFIQTERPTAKNPTTWMLFDIGKKCQEDKDHCIKLKETGTDAEPFDKVVSKLVESSYGYAVMFFLPNEEEKALIETSKESVFLVFILWTDDNGPVKKKMLYAASGQALKTLVSEKIKVCMQCNDKSDLVRSNIFEEVKRKNPHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKS5</accession>
    <name>A0A914BKS5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho GTPase-activating protein 12-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076067.1">
        <property type="nucleotide sequence ID" value="XM_038220139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKS5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220139.1">
        <property type="protein sequence ID" value="XP_038076067.1"/>
        <property type="gene ID" value="LOC119744273"/>
    </dbReference>
    <dbReference type="GeneID" id="119744273"/>
    <dbReference type="OMA" id="SADDICH"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000003">
        <property type="entry name" value="Putative rho GTPase-activating protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="404"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="604"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90522" checksum="B0924DE450326D47" modified="2023-02-22" version="1">MSISMEPPVNTTMVQAKYEYEYMSGSGEPAKMFPGDLFMLLRKSNSDWWYVKRDGDKKPVYLPATYLEIQPDNAVLGQGNLTTKRGSLIPHAHVEGSSERLPSVPATNTAASQVRHNNMVSKMSGRLRNQVIIPKPDYENVAQEPASKQRPTQLSVRDSNGRQGFAKVVTPVGGAMSPMTDSEPSSHSEQSSVNSPEYFPPPPNAAELRSHFSNSNLPQLAVSAQPVPSSGEEWETHRDERGRKYYYNPSTNETSWDPPPTLTAKKRSPNISPKPHKKSEPTLQPLPPGWREEKTPNGGDVFINDQFKEKWYKSQNEQGETYYYSGDREETGWSLPTESPSIRRRKSEESAADVEVQRRPRRGLSERGSKTMSVFLPSESRFLMNVHRRHSEIESGDIHPETASSEKEGYLQRARPGEATRKVKWQTVYTVMTGSSLAFFKDHKVKSGTPVMMLELWGSHVVLHSEKQSKYIKKSYIEFKTPLDKEYWLMADTEDETHLWYTAINGAVRSMPAASHRPLRRQNSADNAFSPTNDGPSLRPTSPNPAARPTSPRPRPENLIEISSKSKQDKKKIKNKLKSFITKRPTIESLQKQGIMKEEDVFGRHIQTLCQQQGTVVPRFVTDCITLIEKSGLHVDGIYRVSGNLSLIQKLRFLVDQEKPVDFNSSPWKEDIHVIAGALKLYFRELPEPLVTFDGYGGFMEAMRKPDRKSRLRAFQDVLSTLPRVNQETMKVLFRHLNRVVDHKDKNRMLPQNLAIVFGPTLMWPRQESFNVALTMVYQNQCIEFILNEHLQLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL25</accession>
    <name>A0A914BL25_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076172.1">
        <property type="nucleotide sequence ID" value="XM_038220244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL25"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220244.1">
        <property type="protein sequence ID" value="XP_038076172.1"/>
        <property type="gene ID" value="LOC119744362"/>
    </dbReference>
    <dbReference type="GeneID" id="119744362"/>
    <dbReference type="OMA" id="KAATTYM"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="23">
        <location>
            <begin position="33"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="55399" checksum="298F40A1A222E143" modified="2023-02-22" version="1">MTISETEVTPISPSKTTSSRERARRRWVTVEPVVSLTVVGYITIGLLRPFYLKSRLGELMFNITEQEEIAKCQANKSDGGVTEDEIQSEASLWLLYLSAATNIPVVVSSIVIGTLSDRLGRKLSLVMAIIGYICQEIVYILTVYYKLPLPVLLVGDFLQGVGGGFMTLFAGCISYISDITLEKQRTIRIAVVEMMMFFMGGVVQVGAGYLLSAFGPIPPLAVALGLNVLCLMYVAIPGILIETVDRNTIPEHRKGFKDAGMSVVKLLKFNENGRRWQMLLLNFFIFFVMLNVNGVMTIFILYGTAEPFCWSAVTAGLAGAFGFITGSIGMVAGTKLFSFCLGEYWIMQISCLSLLAFNVVMSVSNTTLLVFIANAVGALRGMGVPIARSVLSTIVDPSEIGAAFSIVACIDNLSSFTSSLMIPSIYATTVSFMPQVIFYVLSGLSIIPSGIILILQIHWPRRKDYKALEDSGIYEDGPREEDLKEKAATTYMSIPKTVQIKESTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLZ0</accession>
    <name>A0A914BLZ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077134.1">
        <property type="nucleotide sequence ID" value="XM_038221206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLZ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221206.1">
        <property type="protein sequence ID" value="XP_038077134.1"/>
        <property type="gene ID" value="LOC119744982"/>
    </dbReference>
    <dbReference type="GeneID" id="119744982"/>
    <dbReference type="OMA" id="YPSANER"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000357">
        <property type="entry name" value="Motor neuron and pancreas homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="279" mass="31069" checksum="0A2857E093C0F02F" modified="2023-02-22" version="1">MARQGHVSPNEIQSANVGLLGASGAPQTSPLGPVKAAPLDISNDKRLSTLEEYSALKITSLHLHDYNLLTVNSIPYLCASSSTGHQHPTILGKTRRPRTAFTSQQLLELEQQFKKNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRGKKVKETPSVEGEKEAAANSDEGRPDHAPAPLEKTHEDGDHITKVEVHGGNESVDGLEIHDEEYYDEEDDDDMDDDMMAEGYIQDSSSDERANNNVEDSDNCNSGGGRNRYSSAAERSLDCHPVEPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM07</accession>
    <name>A0A914BM07_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077154.1">
        <property type="nucleotide sequence ID" value="XM_038221226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221226.1">
        <property type="protein sequence ID" value="XP_038077154.1"/>
        <property type="gene ID" value="LOC119745001"/>
    </dbReference>
    <dbReference type="GeneID" id="119745001"/>
    <dbReference type="OMA" id="SQTAHPC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="255" mass="27168" checksum="364D0790177EB7A9" modified="2023-02-22" version="1">MNSHQPPTPPPSLPHTPIYPTPLPPPYPTPLPNTPTPSLPKTPTPSLPNTPTPSLPKTPTPSLPNTPTLSTQHPYLPYTPTLSTQHPYPSLPTPLPPPYPTSLPSLPKTPTPSLPNTPTPSLPKTPTPSLPNTPTLSTQHPSLPNTPTLSTQHPYLPYTPTNCTHTPTPSLPNTPTPFLPKTLLPPYPTPLPSLPDTPTYPSPLPSVPNTPTPSLPNTPTPSAQHPYSPLYHSPHPYPLYPTPLPTLCDSPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM81</accession>
    <name>A0A914BM81_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="15">PPIase</shortName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="RefSeq" id="XP_038076582.1">
        <property type="nucleotide sequence ID" value="XM_038220654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220654.1">
        <property type="protein sequence ID" value="XP_038076582.1"/>
        <property type="gene ID" value="LOC119744620"/>
    </dbReference>
    <dbReference type="GeneID" id="119744620"/>
    <dbReference type="CTD" id="10465"/>
    <dbReference type="OMA" id="SVWGQVI"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000017">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="185" mass="20262" checksum="8381B8162E41220E" modified="2023-02-22" version="1">MAGNSLTGAVKRHPDNPVVFFDISIGGQDIGRMKMELFADVVPKTAENFRQFCTGEHRDEKSIPIGYKGATFHRVIKDFMIQGGDFVKGDGTGSKCIYHGNSFPDENFRLKHDASGLLSMANSGPNTNGCQFFITCAKCDFLDTKHVVFGKVIDGLLVMRKIENVPTGSNNKPKIPVVISQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMJ6</accession>
    <name>A0A914BMJ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076697.1">
        <property type="nucleotide sequence ID" value="XM_038220769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220769.1">
        <property type="protein sequence ID" value="XP_038076697.1"/>
        <property type="gene ID" value="LOC119744699"/>
    </dbReference>
    <dbReference type="GeneID" id="119744699"/>
    <dbReference type="OMA" id="RYNEYPY"/>
    <dbReference type="OrthoDB" id="10366543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="676" mass="74621" checksum="658DBF639F7805B0" modified="2023-02-22" version="1">MAGTWTRLPVSATLANDLETSTPTPPEQSDIQTVTTTSTLLSSTGGIHTLPPTSTAPSVDTDSQFDKGWTDTSTPFMTTDTFQDPSDFPASTPLYKPRADDNFTDQQEFGGSSIIASSVVTATVSEIITENGASTTTQASFSPYDKFKLGLIITLSIVIGCFAITAISLRIRSRIKKRRLELEIVKKKRKNAAGNGDSKPPVKRVTIKMCTDSNSSTRRTNKRPLRRSHSPSLQSRAKIPEIPIGKDMDRNRTLDALLDAGTYIPIAPPPLGMARDRTKSDVSSRTGLIMGGKSCDAEEHAYDNPVISSAEEMTTEVSMLSEETCPPLRMKIDAEVHRSNLDAMTHNASDSEDGSVEKGNFIESSETESLSDARRRFKLNHYFGMRSSQRNDSKDSGYVESFISQDSLRLRAMASLEEGRALADGMSVAAGHERMLPRLGSIEPTLFMASVDETSNLNLNRSGSVASDNDGLPHPKVCRNNIMNMRQSRYSVPSFPTQYPQCFPHHRQPNRNPYHDMYGAPYGMPYQAITPRYPSSECSAYDYASTQSDFGPAPRRNSYVNRILPKSLSCETTMYKSCDLISPQHKTGIQDYAHQKRVKRFVKHRSLGTQTGDSDNVKPMVRWDYDNAGSLVAKPRENAGIDFIGPIYMAEELEEMGPHKTQCVIDMETATSTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ35</accession>
    <name>A0A914BQ35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078398.1">
        <property type="nucleotide sequence ID" value="XM_038222470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ35"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222470.1">
        <property type="protein sequence ID" value="XP_038078398.1"/>
        <property type="gene ID" value="LOC119745835"/>
    </dbReference>
    <dbReference type="GeneID" id="119745835"/>
    <dbReference type="OMA" id="IMACGIM"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="46341" checksum="3E33D1343669E07B" modified="2023-02-22" version="1">MAKPGMGQPPVSDGGFQGWIAVLTLLVRNMIWIGITKGLGVMLPTLQDQLASDTWVLGWIAAMVITVSGIIAPFSGILNRRFGVGYVIMACGIMIGVAPIVGSFVETAAQLAVVYILAGVGLEVSCVVAKEAVGRRFTKNYATASGIGRTGYSIGLFVFAPLVQLLLDTYGWRGSMMLIGGICLHFAMCGALLVTSNQDKPQSTEYQRISDQESNSQTNQTNLAHRCSELRESLLWNFDLRLLVNARFWALALLMCCTIFADDMWIIYFVSQAQSNGFSTEDAGLFVAVGGVGSLVAKVCQGPLTDRGVISSWSLTGTFIIIGSATYCATPWLTSYWAMMVSASMVLFCGGLITCQTDVLIKLILGVELLSGAFAWMALLTSTLAFTMGFFPGLLYDLTGSYTVSFTMVGVVQALPIVPLALLRYFHDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQB0</accession>
    <name>A0A914BQB0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078334.1">
        <property type="nucleotide sequence ID" value="XM_038222406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQB0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222406.1">
        <property type="protein sequence ID" value="XP_038078334.1"/>
        <property type="gene ID" value="LOC119745799"/>
    </dbReference>
    <dbReference type="GeneID" id="119745799"/>
    <dbReference type="OMA" id="DCMVTED"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="85"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28727" checksum="43DA21D1029D8EEE" modified="2023-02-22" version="1">MQSEQLQQELPASSTVTMATENRMNSAQLPDEIFLYHVLPLLSIREVNSCKLVCKTWRHLVTTYIKRLKVIDLTPWDCMVTEDLLLGIVKHAANVRELRLDGCWRAVRDAAVLTVASVCHKLRVFAACKCGNLTDAGVISLAEKCPELEELDLSSCYGITDEALCGLADHAKNLKELHVSSVYGVTDFGVSQLAFKCHLLQNLDVSYCYVVSNLGLQAFLDKQGKLALTELRVKNCYKVTQPTIFKLMQAGVAVNNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQJ4</accession>
    <name>A0A914BQJ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual oxidase maturation factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077762.1">
        <property type="nucleotide sequence ID" value="XM_038221834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQJ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221834.1">
        <property type="protein sequence ID" value="XP_038077762.1"/>
        <property type="gene ID" value="LOC119745472"/>
    </dbReference>
    <dbReference type="GeneID" id="119745472"/>
    <dbReference type="OMA" id="FMVIRYC"/>
    <dbReference type="OrthoDB" id="10042652at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54276" checksum="E807A15CF3045718" modified="2023-02-22" version="1">MGTPYSALRNPGSPTAYGPNKTAVSADITYAGLVYAFFILAVSFLAILPGIRKRNRIYAAIRFFLGLFIGFTILLSTYGQDWEVASLKSVTTAYKAFTKDEIVADIGVNIGLTNVNVTLKSIPEYPETGELKGERINFNERFTFCCNQGRRGFGTFAGRINREFRDAQWKGLPYPILWIVEYFTLDGEDIRWGRSYRVAGFYTFMVMWTAFCLWVLALAFSFMVIRYCGIFLVLTGSCLLSSNIIYATVRYGSELVIPFSKDHVLEFSKGGSFYLCLVGGIVSTLVGIAIVILDDIYPFKMAVFFNVDPLQDFQDTFAVTTSSPAENVQGNTGPQTGKDGRPLSVLNEDLRVEALAAEALGNKESEAYKGNMYINVAQMKASFKSGRKSLFQKNKPRRKKKPEGAGSRNDGFDLGEVDTGNTSLLQSVTPAPISFKAKGMGESTTVEDTVATDRNAGLSTTSIRMSEIALRDDVDSEDVGEKKQDDPKEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BR22</accession>
    <name>A0A914BR22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078743.1">
        <property type="nucleotide sequence ID" value="XM_038222815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BR22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222815.1">
        <property type="protein sequence ID" value="XP_038078743.1"/>
        <property type="gene ID" value="LOC119746050"/>
    </dbReference>
    <dbReference type="GeneID" id="119746050"/>
    <dbReference type="OMA" id="LEKNEHC"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01504">
        <property type="entry name" value="PNCREATITSAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036929098" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18819" checksum="9E61F25791779C72" modified="2023-02-22" version="1">MRFIGFLVLLLVSVSLSSDGGVAALCSSPYCPPPWRAFQGHCYLWVDKPMSWMDAERYCQMLSHPGKMVHLASIHSEEEDEFIKMYVRKSSASPTPTPYWIGCSDIEQEGHFRWSDGSDVSYEGWWPGEPNNVGEEDCTENLFQFSGKWNDVRCMNENNFVCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSX5</accession>
    <name>A0A914BSX5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078706.1">
        <property type="nucleotide sequence ID" value="XM_038222778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222778.1">
        <property type="protein sequence ID" value="XP_038078706.1"/>
        <property type="gene ID" value="LOC119746022"/>
    </dbReference>
    <dbReference type="GeneID" id="119746022"/>
    <dbReference type="OMA" id="VYKRLIC"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="24547" checksum="2B53CCA3C682F569" modified="2023-02-22" version="1">MASTTSQIIHKTHMLNHDQMLDYYADWADSYDADVKSSGYEAPRVCAEALGKVLSDKSALIVDCAAGTGIVGEELKNIGFKTIDAVDYSQQSLDISASKGVYKRLICNKFDENKIEEIKDDSCSALICVGALSMNHITQTAFPEWNRIVKQGGFMVFTLSRVEYDDGLPDHRLVIGNGIQELLDKGTWELIDKTAIPYHSGYLADMFTIRLKNQKRSLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWF7</accession>
    <name>A0A913YWF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038044129.1">
        <property type="nucleotide sequence ID" value="XM_038188201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188201.1">
        <property type="protein sequence ID" value="XP_038044129.1"/>
        <property type="gene ID" value="LOC119718781"/>
    </dbReference>
    <dbReference type="GeneID" id="119718781"/>
    <dbReference type="CTD" id="6472"/>
    <dbReference type="OMA" id="CATTHKV"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="44"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="500" mass="55551" checksum="B0EFED73D2F842CE" modified="2023-02-22" version="1">MASRSLSRLLSLRPAIQNVSRATYGQQATLQSQQVPDWTGQEILSEVDPEILSLIREEKQRQVRGLELIASENFCPQASLNVLSSCLHNKYSEGLPGNRYYGGTEVIDKVERLCQKRALEAFDLDPEKWGVNVQPYSGSPANLAVYTGLLAPHDRIMGLDLPHGGHLTHGFMTDTTRISATSIFFESMPYRLDIKTGLVDYDKLEETSRLFRPRLIISGYSAYPRRLDYKRFREICDGVKAIMMSDMAHISGLVAAKILPSPFDHSDIVTTTTHKTLRGPRSGLIFFRRGKKGVSKKTGKDIMYDYEKRINHAVFPALQGGPHNNNIGGVAVALKQTMTPAFKEYQRQTVLNAKTMAQALLAKGYSLVSGGTENHLVLVDLHSKGVDGAQAEHILELCAISVNKNTCPGDKSALHPSGLRLGSPALTSRNFKEGDFLQVIDFIDRSIAIGQEAKKISGANNKVYYEVVETNKEFLKKIAKLRLEVEDFAAQFPMPGYDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXV9</accession>
    <name>A0A913YXV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038044202.1">
        <property type="nucleotide sequence ID" value="XM_038188274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188274.1">
        <property type="protein sequence ID" value="XP_038044202.1"/>
        <property type="gene ID" value="LOC119718854"/>
    </dbReference>
    <dbReference type="GeneID" id="119718854"/>
    <dbReference type="CTD" id="4329"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="56421" checksum="0331DF505781E5BD" modified="2023-02-22" version="1">MLRLTSRVPGVLGALRRYSSHAAPTTKMFINGEFVESKTTEWIDLHNPATNEVVTRVPKCTQDEMQSAVDAAVAAFPSWSETSIMTRQQIMFRYQHLIKENLSEIAKSITLEQGKTLVDAEGDVMRGLQVVEHTCNITSLQLGETLPSIAKDMDTYTMRVPLGVCAGITPFNFPAMIPLWMFPVAAVCGNTYVIKPSERDPGACMMLVEMAKQAGLPAGVVNVIHGQHDAVNFICDSPAIKAISFVGSDQAGIYIHERGSKNGKRVQANMGAKNHGVIMPDANKENTLNQLCGAAFGAAGQRCMALTTAVFVGESKEWIPDLVERAKNLKVNAGDQPGADLGPLISPASKTRVCDLVQSGVDEGATMLLDGRDIKVPGYEQGNFVGPTLLSDVKTDMKCYKEEIFGPVLLVITVDTMDEAINLINENMYGNGTAIFTTNGATARQYTERIDVGQIGVNVPIPVPLPMFSFTGSRGSFRGDTNFYGKQGIQFYTQLKTVTQLWKAEDVSHTKAAVAMPVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY54</accession>
    <name>A0A913YY54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">ATP-binding cassette sub-family B member 6</fullName>
            <ecNumber evidence="30">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">ABC-type heme transporter ABCB6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="45 46">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66768"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167478"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:66681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19262"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58687"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:61361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:61337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167480"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:66773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66776"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167479"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:66777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Melanosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_038044684.1">
        <property type="nucleotide sequence ID" value="XM_038188756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YY54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188756.1">
        <property type="protein sequence ID" value="XP_038044684.1"/>
        <property type="gene ID" value="LOC119719340"/>
    </dbReference>
    <dbReference type="GeneID" id="119719340"/>
    <dbReference type="CTD" id="10058"/>
    <dbReference type="OMA" id="YYGAEHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000022">
        <property type="entry name" value="ATP-binding cassette sub-family B member 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="27" id="KW-0458">Lysosome</keyword>
    <keyword evidence="25 42" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <keyword evidence="21" id="KW-1278">Translocase</keyword>
    <keyword evidence="15 42" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22 42" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="42">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="44">
        <location>
            <begin position="316"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="43">
        <location>
            <begin position="643"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="41">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00024320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00024385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00024439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00031413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="904" mass="101976" checksum="C1960EB0B340BD5D" modified="2023-02-22" version="1">MTCLQGKSSPILEIPLASCKQQRRGQYTSRICKIRGGLLDFCLRPSQVIDTMPNNTQFCPGSTSLVPVWVDNGLNRCFLDTVVTSVLLFLILVPGGVQILLFLRRAVLVEQRFRVRPLWFRLQVALSVLMVLQYGTRLAVLGVLGNEDDRVDLYGYMELSACFSMACYLISIVILTMERSRTMMSRRRQGHGFVLLLFWTLAFVNENLAFISWLSPHWWWGFDSEVQQAELSLWIVRYFCTLLLFAVGLRAPGLPRKSYTLLINEDGNEEQEVPLIATDDSTSRQKSTWADAWTKTKMVFPYVWPKGHYLLQLRIVLCIFILVAARVVNVYVPVLHGEIVDALTPIAKGDRVQFPWQLISIYVSLKFLQGSGSAGIGLLSNARAFIWIKVSQYTTKSIMVRLFGHLHSLSLKWHLNRKTGEVLRMMDRGTTSINSLLSYIIFQIVPTIADIVVAIVYFITAFNAWFGLIVLVTMTFYIAATIAVTEWRTKYRREMNLGDNKMKQKAVDSLLNFETVKYYGNEDFEVSVYDESITSYQRSEWKSIASLVLLNSAQNIIITSGLLVGSLLCAYYVSETKLTVGDYVLFASYIIQLYGPLNYFGTYYRMIQQAFIDMENMIDLLKEKQDVADFPDAKDLQVKKGVVEFDNVSFAYNVEKPILKGVSFAVQSGQTVALVGPSGAGKSTIIRLLFRFYDIQDGQIRIDGQDIKKVSQHSLRKVVGVVPQDTVLFNNDIRYNISYGKIGSSEEEVSTAAEAADIHTRILSFPDKYKTVVGERGLKLSGGEKQRVAIARTILKAPEFVLLDEATSALDTKTERNIQSSLANVCANRTTIVVAHRLSTVIGADQILVLQEGHIIERGRHEDLLQLNGVYADMWLQQQQAEEEDENKSGDEDDSTGSGPEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZC3</accession>
    <name>A0A913YZC3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044923.1">
        <property type="nucleotide sequence ID" value="XM_038188995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188995.1">
        <property type="protein sequence ID" value="XP_038044923.1"/>
        <property type="gene ID" value="LOC119719535"/>
    </dbReference>
    <dbReference type="GeneID" id="119719535"/>
    <dbReference type="OMA" id="QDDTFFP"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="252" mass="28066" checksum="596D705C96A91CF7" modified="2023-02-22" version="1">MIKLGAFCRCDIRAGVRSLVTDYLTAASARPTVRKPNKQGILCTSKNYCLPKVSTGNAHPGLPHFVHCTVFPATMPSNVEIKAHLREPDFVRKKAQELSGNNTSEVLHQEDTFFHCPNGRLKLREFKEDPTKLSQLVFYDRPDTTGPKLSKFSVTESHHPDQLKSTLSLALGVKGIVKKTRTLIMVGQTRVHIDEVDRLGSFMELEVMMQPDQTTADGTKIADDLMEELGIQPSDLISCAYMDLILQNVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2A7</accession>
    <name>A0A913Z2A7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">28S rRNA (uridine-N(3))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Centromere protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kinetochore-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">SPOUT domain-containing methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine in 28S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83635"/>
            <dbReference type="Rhea" id="RHEA-COMP:20178"/>
            <dbReference type="Rhea" id="RHEA-COMP:20181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:83636"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045984.1">
        <property type="nucleotide sequence ID" value="XM_038190056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2A7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190056.1">
        <property type="protein sequence ID" value="XP_038045984.1"/>
        <property type="gene ID" value="LOC119720391"/>
    </dbReference>
    <dbReference type="GeneID" id="119720391"/>
    <dbReference type="OMA" id="PIQPRLE"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000170">
        <property type="entry name" value="SPOUT domain containing methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="42026" checksum="B7A4DAF0E33858EA" modified="2023-02-22" version="1">MGKAAQHLLGLTDHLHRTWAIDGKGSSAPTWLDGPPAPNLGHRRGRQLSTYLQLHCFKFFSRNFTFLHVGRAWTVSVALPGSILENAQSPELRTYLAGQIARAMVVFCVDEIVIFDESGMPSENTDGNFDGIGKKGNPNVQLARILQFLECPQYLRKNFFPMHNDLKFAGLLNPLDCPHHLRIDEACPYREGVVLDRAVGQGKGSIVNVGLLKEVRIDRQLQPGLRVTVEMADTDHINSERKTLRGTVVSPAAPCTEAGLYWGYSVRLASGLGAVFSQSPYKDGYDVTLGTSERGTDVDQLQLSAFRHLLIVFGGLKGLEYSLDADERLKITDPKLLFDHYINTCPTQGSRTIRTEEAILISLSSLRSKVNQVASHTNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6T7</accession>
    <name>A0A913Z6T7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046721.1">
        <property type="nucleotide sequence ID" value="XM_038190793.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190793.1">
        <property type="protein sequence ID" value="XP_038046721.1"/>
        <property type="gene ID" value="LOC119720927"/>
    </dbReference>
    <dbReference type="GeneID" id="119720927"/>
    <dbReference type="OMA" id="WITFNPA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="252"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1831"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2071" mass="217218" checksum="AA0F98830E3ED72D" modified="2023-02-22" version="1">MWSKKFNCLPVHLVDKWFGFDCLVDDTVENPVCVHGQAPTVTCPSDVTSCTQSGSTIAIVSWSPMPSATDDVDVFASSDITCQDGGGNGVVSGGTYALGTTTVTCSVTDSSGNEGSCQFDITVLGQDPDADAWWKVDLGAAYCLREISVINVLLDHADQVLEGAVVRAGLNSNHLQNTAVGSPVTLAQAESGEAIHFVSNTVIITRYVSVAFTGKSEFLHIAEVMIEQFEGTTETTTAAETTTTDVTSSADSDTEAPTVTCPSDVTSCTQSGSTTAIVSWSPMPSATDDVDVFTSSDITCQNGGSNVVVSGGTYALGTTTVTCSVTDTAGNEGSCQFDITVFGQASDLDLTSKTASQSSTRGGLPASRAIDGQTSTYSHTDPDADAWWKVDLGAAYCLREISVLNVLLSHADQLLEGAVVRAGLNSNHLQNTAVGSPVTLAQAESGEAIHFVSNTVIITRYVSVAFTGKTEFLHIAEVMIEQFEGTTTAAPTTLRITTDVITEIPATTAAETTTTYVTTKVDPRTTETSTADTTTTKESTTVDATTFPKTSTADITSTKESTTVDKTTFPKTSTAIVTTTKEPATVTVTTFPEKSTADITTTNELTTVKTTTFPKTTTAETTTIKEATTVDITTFPATSTADITTPKESTTVDATIFPKTSTADINSTNETTTVDTTNFPATSTAGITTTKESATVDTTTFLETSTTDITTTKESTTVDATTSPTTSTADVTSTKESTNAYTTTFPKTSTADITTTKDSTTVDTTTYPERSTADITTTKESTTVQTTTIHDTSTTDTTTIKESTTANTTSFPATSTEYITTIKESKTADTTTFPATSTTDTTTIIESITVDTTSFPATRTTDIITIKESTTTDTTTFPATSTTDTTTIIESTTVDTTAFPATSTTDITTTKESTTVETTTFPEIGTTNITTTKESTTVDTTTFPKTSTRDITTTKESTTVDATTFLTTSIADMTTTRQSTTVDVTSFQMTTTANITSTKEPTTVKTTTFPDTSTTDTTTVKESVTAVTTSFPATSTADITTTKESTTVDATTFHTTSTADMTTTKKSTTDKTTTFPDTSTADATTFKESTTADTTTLLATSTADITTTKGSTTVDTTTFSETGTTDITTTKESTTVHTQTFPTTSTADMTTTKESKTVDAITFPTTCTADMTTTKQSTTVDVTSFQMTTTADITTTKESTTDKTTTIPDTITTDTTTIKESTTSDTTILLATSTADTTTPKQSTTVDTIAFPATSTTDITTTKESTTAGTTTFPATSTADITTTKESTTVYTTTFPKTSTRDTTTTKESTTVDATTFPTTSTADMTTTRQSTTLDVTSFQMTTTADITTTKEPTTVKTTTVPDTSTTDSTTSKESITAVTTSFPATSTADITTTKESTSVDATTFHTTSTADMTTTKESTADKTTTISDTSTTDTTTFKESTTADTTALLATSTADITTTKGSTTVDTTTFPETGTTVITTTKESTTVDTKTFPSTSTADITTTKESTTTAFPATSTTDITTTKGSTTVDTTTFPETGTTVITTTKESTTVDTKTFPSTSTADITTTKESTTVDATTFPSTSTADMTTTKQSTTVDVTSFQMTTTADITTKKESTTDKTTTIPDTVTTDTTTFKESTTADTTALLATSTADITTPKESTTVDTTAFRATSTTDITTTKGSTTVDTATFPETSTADITTTKESTTVDTKSFPETSTADITTTKESTTVDATTFPTSSTADMTTTKQPTTVDVTSFQMTTTADITTKKESTTDKTTTIPDTITTDTTTFKESTTSDTTAFLATSTADITTPKESTTVDTTAFPATSTTDITTTKGSTTADTTTFPETSTTDITTTNESTTVYTTTFPKTSTRDTTTTKESTTVDATTFPTTSTADMTTTRQSTTVDVTSFQMTTTAEITKTKEPTTVETTTVPDTITTDTTTSKESITAVTTSFPATSTADITTTKESTSVDATTFHTTSTVDMTTTKESTTDKTTTISDTSTTDTTTFKESTTADTTAFLATSTADITTPKESTTMDTTAFPATSTTDITTTKGSTTVDTTTFPEIGTTDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6Y0</accession>
    <name>A0A913Z6Y0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047459.1">
        <property type="nucleotide sequence ID" value="XM_038191531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191531.1">
        <property type="protein sequence ID" value="XP_038047459.1"/>
        <property type="gene ID" value="LOC119721451"/>
    </dbReference>
    <dbReference type="GeneID" id="119721451"/>
    <dbReference type="OrthoDB" id="10208719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036999495" evidence="2">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="236" mass="26202" checksum="8CC544ACFFA1B45E" modified="2023-02-22" version="1">MAACMSRHCLMLLAGAILALTFVHGLEAAVPSPDKRPCDKQDNDEPETLCRATIDCYCISGTYLDIPCDTFDQDNIDCSSYCKPCPYGKFSPFDNRCLACRPVTPCKPNEEVIIRATGRADQVCGCRRQDLTCPPCPEQTTPTFTSTQVETVVDPSVNPPQEKRATDNQWTFDGWSVVIGIILAMGLVLLVVWIVCILLKERGYHLRLPSSFTVPKLSCPFSASLLRNVKLSWYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBR2</accession>
    <name>A0A913ZBR2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysosomal acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049004.1">
        <property type="nucleotide sequence ID" value="XM_038193076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193076.1">
        <property type="protein sequence ID" value="XP_038049004.1"/>
        <property type="gene ID" value="LOC119722770"/>
    </dbReference>
    <dbReference type="GeneID" id="119722770"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036733288" description="Lysosomal acid phosphatase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51201" checksum="C4ECEDE5A756BC7A" modified="2023-02-22" version="1">MAAPAEFIWCFVIIFAAFCSTSSSNRTLKLTHVLFRHGNRSPIKAYPSDPYQEDTWPQGFGQLTQEGMRQHYELGKWLRQRYVTDSRLLNSSYVRTEIHVHSTAYDRTLMSAQSNLAGLYPPQGRQMWNEQLSWQPIPVFTKPTSENHLLVADNHLDCPRLEELGKENEKLHVHEDYISKNKDFFDTLAKHAGYDVSNVTYQNFTRIADSWYFEIRDGRSLPTWATQDIIDRVLPMLDFSYASEVQNEEYFRLRSGTLLNEVVTHFKAVTEGTETTKLYMYSGHDDNVAWLLRSLNVFNNLGPPPASCVMIELYLEDDKSYTVDVLFKNNTKAEPIKLPMPGTKGPCTLDHFFEITKDCVVTDAVTACKAQGTSGHNSGFLPKTWNTGWILAAGAMLLAVVIAVGMIVLLFIGTRRRKQLRKARQMQPISFRLLGHTATDSEDESVFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG35</accession>
    <name>A0A913ZG35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038050394.1">
        <property type="nucleotide sequence ID" value="XM_038194466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG35"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194466.1">
        <property type="protein sequence ID" value="XP_038050394.1"/>
        <property type="gene ID" value="LOC119723679"/>
    </dbReference>
    <dbReference type="GeneID" id="119723679"/>
    <dbReference type="OMA" id="DIAWIWV"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="11">
        <location>
            <begin position="284"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="648" mass="72105" checksum="072F342720FFED94" modified="2023-02-22" version="1">MSSILRGFIIRQAYNFSKTLASMPACSVSSQAAPVSTIVNGKLNDLQPHVREYVLEKAEVCQPDNIYICDGSEEENKALLAQMEKEGIIKRLTKYDNCWLARTDPKDVARVESKTVISTPYERDTVPIPKEGVEGTVGKWMAPGDLKKAIDERFPGCMKGRTMYVVPYSMGPYGSPLSKIGIELTDSPYVVASMRIMTRMGKKALDVLGDGDFVKCLHSVGQPLPMEKPPVNNWPCNPEKTLISHIPDNREIMSFGSGYGGNSLLGKKCFALRIASRIAKDEGWLAEHMLILGLTNPQGEKKYIAASFPSACGKTNLAMIMPSLPGWKAECVGDDIAWMKFDKEGRLRAINPEYGYFGVAPGTSDKTNPNALATCLSNTVFTNVAETSDGGFYWEGLEDQTPKDVSITTWLGKGNWNKSTGVPAAHPNSRFCAPASQCPTLDPAWEDPEGVPIDAIVFGGRRPKGVPLVYEAFNWQHGVFVAAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNVGQYFQHWLDFEHKPDLKLPKLFHVNWFRTSEQGKFLWPGFGENIRVLDWILKRCNDEDIARPSSIGYVPKEGSLNVEGLDKPVDMDALFDLPKDFWMEEVQQIRKYFDDQLNVDLPKGIASELDSLEERVKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG43</accession>
    <name>A0A913ZG43_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related GTP-binding protein A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049970.1">
        <property type="nucleotide sequence ID" value="XM_038194042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194042.1">
        <property type="protein sequence ID" value="XP_038049970.1"/>
        <property type="gene ID" value="LOC119723422"/>
    </dbReference>
    <dbReference type="GeneID" id="119723422"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000276">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37806" checksum="8967FB67F3EB9AFB" modified="2023-02-22" version="1">MSNLQDIMNGLPLRPTTFTNRRKRKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQEAFMENYFASQRDNIFRNVEVLIYVFDVESRELDKDMHYYQSCLEAILQNSPEAKIFCLIHKMDLVQEDERELIFHEREEDLKRLSKPLSCTCFRTSIWDETLYKAWSSIVYLLIPNVQQLESNLQQFAEIIDADEVLLFERATFLVISHCQRKSQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVKNSAFAAFIDVFTSNTYVMVIMSDPSIPSAATLINIKNARKHFEKLEKITDNPMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHM0</accession>
    <name>A0A913ZHM0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho guanine nucleotide exchange factor 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050532.1">
        <property type="nucleotide sequence ID" value="XM_038194604.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050533.1">
        <property type="nucleotide sequence ID" value="XM_038194605.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050534.1">
        <property type="nucleotide sequence ID" value="XM_038194606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050535.1">
        <property type="nucleotide sequence ID" value="XM_038194607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194604.1">
        <property type="protein sequence ID" value="XP_038050532.1"/>
        <property type="gene ID" value="LOC119723756"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194605.1">
        <property type="protein sequence ID" value="XP_038050533.1"/>
        <property type="gene ID" value="LOC119723756"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194606.1">
        <property type="protein sequence ID" value="XP_038050534.1"/>
        <property type="gene ID" value="LOC119723756"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194607.1">
        <property type="protein sequence ID" value="XP_038050535.1"/>
        <property type="gene ID" value="LOC119723756"/>
    </dbReference>
    <dbReference type="GeneID" id="119723756"/>
    <dbReference type="OMA" id="IMFFEVT"/>
    <dbReference type="OrthoDB" id="6019202at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000016">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032409">
        <property type="entry name" value="GEF6/7_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16523">
        <property type="entry name" value="betaPIX_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16614">
        <property type="entry name" value="RhoGEF67_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="93"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="72019" checksum="06EF0BEFE115A7CD" modified="2023-02-22" version="1">MTANTTMTDFMADWTIKRVKARYDFKGDGDDTLSFSKGEIIAVTQIVDGGWWEGMSNGQVGWFPSNFVKDIKPADGTPKTNEETLEEKEKLKYYEQVVQALLESERKHEQELRSLLTTYLRPLESANILSASDFTLLCGNIEELLTFQQSLLASLEETAKLESRQKRVGACFMRASTQYKSLYSSYCANHPKAVHVLQDHSEELGKFMESKGAASPGMMTLTVGLSNPFRRLDNFISSFQELERHILSSHSDRIEIQTSVSVYRDIKNHCLRVRKLKESELEIMTGTIQGWEGEGIDTYGTIIKFINAAIMVDGIKKERFLLLFPSCLVVLSATAHMNGYIFQYKIPLAAIKTSRQPDTNPNYVAFDLTGGSIEWQTIVCGSLMDREDLLDTIDEMQNKDRPPLTPSTPLTPVPPMSPAMLPQSPTMAASQAKSNSLTRKERNSSSTSPTRTKDSLTTVFTKMKLKTISCLRPGPPVSPITVWALKEGQAKSPKNKKKALHGSRKKAEKSKTLPMDSSAHKGVDTQALEEDNRILKVIEAYCTSVGSRNTINSVPVDPAPHVFLAEEEKIIHEETQGNETIVEEKSLIDTVYALRDQVKDLVDETKRLKRDLDDERRARKKLESTVRKSMKSIDIKLDDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHQ3</accession>
    <name>A0A913ZHQ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038050570.1">
        <property type="nucleotide sequence ID" value="XM_038194642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHQ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194642.1">
        <property type="protein sequence ID" value="XP_038050570.1"/>
        <property type="gene ID" value="LOC119723782"/>
    </dbReference>
    <dbReference type="GeneID" id="119723782"/>
    <dbReference type="OMA" id="SIDWCEL"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071602">
        <property type="term" value="P:phytosphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="274" mass="31227" checksum="6AC63579C36A8972" modified="2023-02-22" version="1">MAPMKDLDGVWGKPTSTLDWCEVNYVVTPYIAEFWNTVSSLVLVFIPVLDLVYTKLTAPKWVHMEWRNYMACLAFISVGLGSLLFHMSLLYESQLLDELPMIWGTCVLVYLFFENNSKPSSQSYALVLFLILYSSAVTAIYILVINPIFHQIAFMFLVTAAFGRGAYCFFYLKMDCSPVLFFLSVLLFFCGGVLWLLDNGLCTHLRHIRSVVPAPLGAGLQLHAWWHVLAGLGAHCQFMFSYQSRLRYLKHHTTEWVGWFPLVTIGGKENGHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKN1</accession>
    <name>A0A913ZKN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium-dependent transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051650.1">
        <property type="nucleotide sequence ID" value="XM_038195722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195722.1">
        <property type="protein sequence ID" value="XP_038051650.1"/>
        <property type="gene ID" value="LOC119724606"/>
    </dbReference>
    <dbReference type="GeneID" id="119724606"/>
    <dbReference type="OMA" id="LPKMAMN"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61788" checksum="8302296D9F1D3CAE" modified="2023-02-22" version="1">MAAIYDGDTAKLVEREKVPVKNGQEGTFRTKIGIALTCIGCMVGTGNIWRFPRILANNGGNSGCLQFLMVWLLFLFIWSIPMLIIEYAVGRYTKRSTIVSFQRMIGDNNMWGGAWIAMVTLGIAAYYSVIVGWCLYYLFHFMVNELPTTSVESNLIFYNFVEDSWWPVLCHFVAILFGAVSVAWGVKSIELANCIIVPIFLLLLLFTFIWTMTLEYAGRGLQFMFSPDWAQFKEPRMWVDAITQNAFDTGAGSGLFVSYAAFMTAQNGIVRYATLVPICNNVISLFCGMLTFSTVFATEVKNGSSTEEIVALLKENGPGNTGLTFVWMPILYNQINGGRVLTVIFFFSLLLAGFSSLVAQLELFVHNVKDFGVSRKKATLAVTVLVFLLGLGSALSLDFLVNQDFVWGFALLLSGMALQYLVIRFGAKRFRQELANNFSESDWPLPVIWEWIVKFIAPLEAVALIIWWIVTTIQESNPWYGFSNESFMITIVQWIGFFGLILLLNLLYVKFIKRFAPIPNDDIALPLPASDGTDKGSEGRYKTFNEETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLT4</accession>
    <name>A0A913ZLT4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052294.1">
        <property type="nucleotide sequence ID" value="XM_038196366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196366.1">
        <property type="protein sequence ID" value="XP_038052294.1"/>
        <property type="gene ID" value="LOC119725000"/>
    </dbReference>
    <dbReference type="GeneID" id="119725000"/>
    <dbReference type="OrthoDB" id="10064741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132002" checksum="4FFD99469994A81F" modified="2023-02-22" version="1">MSEHHADDVLAEENRDESVASKHSGSQRTNSSSSSRNSHLSGLSDKDAAKMRTLRRRIRLNELECQLQEDQTADEQLRKLDEQARSARLKAEEVERQALREREALISKLSRQCRVRIARQELLEAEAISAMLNNESSSSPSPSHPLMGTDDQSPPQSASSTPQPDMEQTSTSVSSSFCHGNPSAPLVTSHPDIQQAPPCVSSSVCHPTPSGAPSSTSPPNIQQTLPCVSTSACHGAPVSATFSASVVTSDVTPRQGIPTPGTCPPHLPYPMASVPSLTVSSAPTVMDLLVASSHGIPKPTLPKFSDGKEKEFALLKLALVNLIDVHPHLSEQYQFQILIDRLGGRALKLAKSFLYASQPYTQALQALTGKNGQPRQLVQSEIGAIMSTPSIKYGDTDAFDDFSLDVLSLVGMLQALEGAEGVELRCGSHVDRLLGKLAPSHRNSFIEHCLKKGILEPNCSKTYTLPQFAEWLRTKSQSQSFASRAVSSHNSAGSKPTHQQSQHRAPKKEVSTTVFMASPNTKDKPKFKPKPYCPYCDNKEHFLGGCPEIKKLSTDQIIQWIKDKGRCWKCGRTHKPEDCTLKKPCHTCKEIHLTVLHDAAKKATSHVYRLQTSNQAVFVDKPTRPHNVMLKILPVTLHGPGGSIDTYAILDDGSERTMLLQSAAARLKLHGNPETMLLRTVREDIVECQGQSCTFQMSARDKPEVMYTVTGAFSASNLCLFQYTYPVEDLQHRYSHLRHLQLPVINNASPQVLIGSDQADLIVARHPIKSGKRGAPVAINTKLGWTLQGPAGNQKQLKEQKVFKTSLFPQTTDIMQHVERLWQADVLPYLNDKQATRSKHDQQAVQMLEATTQRVQVNGIWHYATPLLRQGDEMKFHAPKEAVLPTLKGTEKRLDKYPQLAQKHNELIAKLVDAGHVRILPKDEADKSEESWFIPHHTVYHNGKYRLVFNCSFRYNNQILNEHLLPGPTLGASLIGVLLRFRQHTVAISGDIKAMFHQVRLLPEDRCLFRFLWRNLQVDKEPDVYEWQVLPFGSTCSPCCATYALRKHAFDHEKDYPEVAKAVDKSFYVDNCLQSLPVETDAKALVQKMRNLLSDGGSEIRQWASNVPAVVEDLPPDARSDGCELWLTFGETNSTEATLGMLWECSSDALLYRHRPISYDCLNMRNMYKILASQYDPIGYLTPFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMH8</accession>
    <name>A0A913ZMH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052554.1">
        <property type="nucleotide sequence ID" value="XM_038196626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196626.1">
        <property type="protein sequence ID" value="XP_038052554.1"/>
        <property type="gene ID" value="LOC119725272"/>
    </dbReference>
    <dbReference type="GeneID" id="119725272"/>
    <dbReference type="OMA" id="LLWCASH"/>
    <dbReference type="OrthoDB" id="6769862at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="107"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47765" checksum="8DCDF42FFB8649D1" modified="2023-02-22" version="1">MAARPHGLEGQCSSSKLEGCKRLRFSSVFTSSENPSKDPQRGSYSCSCRSSMEDSSLVPHAAGTSNRRATAPPTENRSPSASPQSVTSSSTDRPPPTGRMEVIRANLSSEGLSQTVSATILASWRPQSNAQYNSAWRRWASWCLQRKLDPVHTPVADFLEFLQQLFDEGLSYRTINGYRSAISSAHCLIDNLPMGQHRLVKRFFKGIFGLRPPRPKYNSTWDVGKVLGFIKSLPDNRRLSLRQLTLKLAMLLALVTASRRASLTAIDVDNMTRSSDGKYRFLLVKPSKCVSVSKPFHQIEISKFQPVRNLCPVRSLEEYLQRTQHHRGTGSSRMTQLFLSHSKPFHPVVPSTISRWLKDLMSQSGIDTSQFQAHSTRSASTSAAARAGVSTSEILKTADWSSASTFANFYHRHLPLSDFGGAVLSSATQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNN2</accession>
    <name>A0A913ZNN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053342.1">
        <property type="nucleotide sequence ID" value="XM_038197414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197414.1">
        <property type="protein sequence ID" value="XP_038053342.1"/>
        <property type="gene ID" value="LOC119725825"/>
    </dbReference>
    <dbReference type="GeneID" id="119725825"/>
    <dbReference type="CTD" id="10238"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="39068" checksum="1C2B7AB40837CE7E" modified="2023-02-22" version="1">MASLPPKRKEIYKYEAPWTLYSMNWSVRPDKRFRLAVGSFVEEYNNKVQIVSLNEETSEFEARSTFDHPYPTTKIMWIPDSKGVFQDLVATSGDYLRVWRVGETDTRLECLLNNNKNSDFCAPLTSFDWNEVDPNLLGTSSIDTTCTIWGLETGQMLGRVNMVTGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLAWNKQDPNYLSTMAMDSFEVIILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTADGEINHIQWASTQPDWIAICYNNCLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP39</accession>
    <name>A0A913ZP39_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052880.1">
        <property type="nucleotide sequence ID" value="XM_038196952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP39"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196952.1">
        <property type="protein sequence ID" value="XP_038052880.1"/>
        <property type="gene ID" value="LOC119725528"/>
    </dbReference>
    <dbReference type="GeneID" id="119725528"/>
    <dbReference type="OMA" id="VRIFPCM"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037989605" description="MD-2-related lipid-recognition domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="158" mass="16964" checksum="15721398BE64B809" modified="2023-02-22" version="1">MSSSTMFKLFLLSAVLSFYLSSGQKVNPLPCKGVTQDATVSEVDIMPCPKFPCQFKRGTNVSVAITFTLNAGATTASSATTVVHGIIGGVSVPYPTAYTDACKTTGIHCPLAPGVKNVYKAQLFVKPEYPTVNLYAKWELQDQTKADIFCFEIPAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ74</accession>
    <name>A0A913ZQ74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053933.1">
        <property type="nucleotide sequence ID" value="XM_038198005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198005.1">
        <property type="protein sequence ID" value="XP_038053933.1"/>
        <property type="gene ID" value="LOC119726349"/>
    </dbReference>
    <dbReference type="GeneID" id="119726349"/>
    <dbReference type="OMA" id="AVACHIT"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="41280" checksum="7CCF7D4D1AB58880" modified="2023-02-22" version="1">MDGDLTNSSFNKSTKNPPFEFNDYKQRVIVAIMFLIVILLGTVGNSLVILAVILSKKLRTTTNAFVVNLGIADLSTCLVLPWSFVAILSTNGFPVGEWVCSVTVVIQATSIGCSLYTLAFIGLQRLLLIKRPMTTYRDIYTPRKIAVWLAVTWSIPLLVTIIPPLADVGAVGYDKKYHICGYPSDHPRANAYDLIVVIGYYPIPLITIIVCYVLIWKQLHDHAKKMTAPKSSAPHMTVVSESVTTVNTGSNHASTSTEGTLSQSHLSRHQTEITKNMFYIVCAFMLCVSPLMICILYDAVDACSPFFPFTFAVLLFNSCVNPLIYATKHRDFKTVFRCILRRKWEDIPEPSDFLKTMISGERPFCGGGGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR49</accession>
    <name>A0A913ZR49_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053620.1">
        <property type="nucleotide sequence ID" value="XM_038197692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR49"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197692.1">
        <property type="protein sequence ID" value="XP_038053620.1"/>
        <property type="gene ID" value="LOC119726076"/>
    </dbReference>
    <dbReference type="GeneID" id="119726076"/>
    <dbReference type="OMA" id="LMTHSGX"/>
    <dbReference type="OrthoDB" id="8895262at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000882">
        <property type="entry name" value="Predicted gene, 21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001155">
        <property type="entry name" value="Zinc finger 30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="641" mass="74859" checksum="04665C825BFD5F5C" modified="2023-02-22" version="1">MTHTSDKQFRCDICQQSFKWKKHLKRHQMTHTNEKPYACYICGTSFALHDNLKRHKMTHTNEKPFTCDICGKSFTTSGSLKRHKMTHTNEKPYACNICGMSFTNSGNLKRHQMTHTDDKPFLCDICGQSYKYMKYLQQHQMTHSNEKPYTCDICSTVFAWRSNLERHRRFHTKKTLMDEKPYACDIFVGISFAQNGDLKQHKMTHTNNRERVFACDFCGKGFDAKRYLRRHEMIHTNEKPYECDICGKSFTQNGNLKQHKMIHKDDKPFTCDICGKSFKLRQNFTKHKMTHTNEKPHACDICGISFAQNGDLKRHKMIHTNEKPYACEICGKSFLLNSSLKQHKMTHTNEKPYACEICGKSFSQSGSLKQHKRTHTNEKPYACDNCGNSFTQNGHLKQHKMTHTNEKPYPCDICGKSFKRKDNIKMHQKIHTNNRERVFACDICGKRFDVKCNLRRHEMVHTNEKPYKCDICGKSFRQNGNLKLHKTIHTNDKPFTCDICGKSFKLRHHFKQHKMIHTNDKPYACDICGKSFTQRGSIKQHKMTHTNEKPYACTICGKSFTGSSDLLRHRRIHTNEKSYTCDICGRSFVRSSNLEWHRRIHIEENRVFQTCEKPQQRPEDAHHGGSICSTGISRIAIINVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS68</accession>
    <name>A0A913ZS68_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054613.1">
        <property type="nucleotide sequence ID" value="XM_038198685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS68"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198685.1">
        <property type="protein sequence ID" value="XP_038054613.1"/>
        <property type="gene ID" value="LOC119726827"/>
    </dbReference>
    <dbReference type="GeneID" id="119726827"/>
    <dbReference type="OMA" id="MEMSHTC"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="126" mass="14393" checksum="D33EB6BE5399B37B" modified="2023-02-22" version="1">MADSSVKNPPPENFKGWLYKWTNYIKGYQRRCNQAEMAHTCRGTINLSGAYIDTEDSCNFVISSGTQTFHLKASSEVERQRWVTSLELAKARAIQMMEEDSDDEEELPSDVDRTELQTTLHILTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSW7</accession>
    <name>A0A913ZSW7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054712.1">
        <property type="nucleotide sequence ID" value="XM_038198784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSW7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198784.1">
        <property type="protein sequence ID" value="XP_038054712.1"/>
        <property type="gene ID" value="LOC119726941"/>
    </dbReference>
    <dbReference type="GeneID" id="119726941"/>
    <dbReference type="OMA" id="MEHANIR"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037757011" description="UDP-glycosyltransferases domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="63156" checksum="1BD7D918AA4913A7" modified="2023-02-22" version="1">MTPSLSTVLLLALLSQLFVLPALTSSKRDDAPDSKKYKFLYFASIIGGSHYVVLARSGRALVHQGHRVVSLVGSSNSNRSWQRDADVFSFVVFNSTYTKQNRTDVMDNLSKVIVKGRHNNFFGPFLNSANLTGRLDLLSLFVQECDDLLGDSTAMERLRKEKFDMLVVDDMIPCGPLLAQALDIPFVHSSVFFVVPSKHGRWTGLPIDPSYIPERNMGLTNKMTFLQRVQNVLAHWFYGFFFFRMGVCNFDGYDKLKVKYNIKPEISTLESHKQALLYFLHGSFALEFARPMQPNTILVLHHPGVHSNQTVWQLEEDVAQFLDTAPSGVVMFSMGTFVTMMERAQAQMFADAFAMLPHRVLWQSGADLSGLRLGNNTLVAKWLPMTQVMEHQNVRLYVGHGAGLSINEALWAGLPIVGLPLVEDQMDILVRIETKGVGLKVDIASMTPKTLSQTIGRVMTEPKFRENARRISEIMRDLETSTSPVDTIVRWILHVTRFGGDHLRPAVQDLSYVQRNLLDVYLFLAVVLALVTWINVTVCCFCLRCICCRGRYKKHLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU00</accession>
    <name>A0A913ZU00_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055067.1">
        <property type="nucleotide sequence ID" value="XM_038199139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199139.1">
        <property type="protein sequence ID" value="XP_038055067.1"/>
        <property type="gene ID" value="LOC119727285"/>
    </dbReference>
    <dbReference type="GeneID" id="119727285"/>
    <dbReference type="OMA" id="TARKMQT"/>
    <dbReference type="OrthoDB" id="5967898at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="371" mass="41592" checksum="309C64E321344959" modified="2023-02-22" version="1">MGGFRSPGLICDPETSLNYTDDVESARKILYTAEDAVIVPILMSVIVGLGLLTNSIFLLVVIRVHHMRTATNHYLVQIALADIIYLIFGAGEKVVRFAVSPVNVDMKWMGTAGCLLVPLLRSLAYFAVLFFMAFVTREKYLAICKPLKYRAINGGQRVWTTLTAWGAALLIAASLAPCSSVFSPYCITWPSAWIPSDLPSLAAQCRPVSEWLNTYNDVMQTFPFFLVMFLTLSMHICIIKTLRVQVAAQTEDLQGPITARKMQTRRQVTRMLVLNGILFFSLLAPFECCSIASSTRMYTTHQLLTSDQFSLLLQIARTLAYLQAAINPLVYYLLHPRYRKACVETFSRGGSTNRQYVNTTDRSNVIAWPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU23</accession>
    <name>A0A913ZU23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Protein deacetylase HDAC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Tubulin-lysine deacetylase HDAC6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate</text>
            <dbReference type="Rhea" id="RHEA:21548"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:21549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
            <location evidence="5">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054576.1">
        <property type="nucleotide sequence ID" value="XM_038198648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054577.1">
        <property type="nucleotide sequence ID" value="XM_038198649.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054578.1">
        <property type="nucleotide sequence ID" value="XM_038198650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198648.1">
        <property type="protein sequence ID" value="XP_038054576.1"/>
        <property type="gene ID" value="LOC119726793"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198649.1">
        <property type="protein sequence ID" value="XP_038054577.1"/>
        <property type="gene ID" value="LOC119726793"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198650.1">
        <property type="protein sequence ID" value="XP_038054578.1"/>
        <property type="gene ID" value="LOC119726793"/>
    </dbReference>
    <dbReference type="GeneID" id="119726793"/>
    <dbReference type="CTD" id="10013"/>
    <dbReference type="OMA" id="HTRSHVN"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032886">
        <property type="term" value="P:regulation of microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0678">Repressor</keyword>
    <keyword evidence="24" id="KW-0804">Transcription</keyword>
    <keyword evidence="23" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="17 33" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="35">
        <location>
            <begin position="1111"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="491"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="989"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="34">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="34">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00050910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00068733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1216" mass="132650" checksum="39F4650F343E4990" modified="2023-02-22" version="1">MEDQPTDPLDHRGSGKDTLQQQPSDQAVQAAATPDDQHGNQGRVPQDASQGQPPKGKHESKQHGPGKKGGKKTNGRTNSALEAVKKKGRENVQQSQTGEDDLAVQMAGMTISETLQAVPSGTGLVYDECLTQHTCPFNSRHFIAEHYDRILMCHKRLQDYKLLERCTHVTVRLALDDEILSVHSADYLESFKTTQTMGDNELKSWAEQYDSVFVNNNTYECASLVLGGLLDLTEKVVKGELRNGIAIVRPPGHHAQRTIACGYSLFNNVALAAHMARHKWNCERVLIVDWDVHHGQGVQYIFEEDPSVLYFSIHRFEHLDFWPHLTDSDSNVFGKGRGLGFNVNVPWNKVGMGDSEYLAVFQQVLLPMAYEFNPDLVLVCCGFDSAIGDPKGEMAITPVGYTHLTHALMGLADGKVVLALEGGYNLKVMAECAAMCTQTLLGDPCPLLPPTTEPDESAVETILDVIKNIRPHWQCYEYQVAPEYVQSDLVSSTSSGKMPSQAIKTDQSPQRGTEQGAGPLDSTVQSAEGLETVDSNTQSEGAATKGVEPVVSTVQSEGTTDKGVEPVVGLTCQSEGTTEKGAEPVQSTIQSVERPTSKEVEPEEIDSLVNRLISEVVLTVPKHRTCLVYDAEMMQHRTAFNHPERPERISRIFSKHEKMGLVQRCLRVESRRATTEELHWCHSAEYIERLQAMQENTSRELYKMQDDFNSIYLHQSSFDCASLAVGSTLNVVDMILSNQARNGVAIVRPPGHHAEAHTAMGFCFFNTVALAARYAQRKFGLKRVLILDWDIHHGNGTQHAFESDPSVLYISLHRYENGMFFPSSPDGAPDVTGQGEGEGYNVNIAWNVDSMGDAEYIAAFTQIVMPIAYEYSPELVLVSAGFDAACGDPLGGYKVTPAGYAHMTHMLSSLANGRVVVSLEGGYNLNSISESMAMCTRTLLGDPCPSIHPGSPCPSAIQAILETLYEHQEYWKSLKYQVNLPTNSSVEDVKAKATSTQNKDAVCSQPRTSSSGGDMDKHGADDTASSSRPYLHDPDGAGECAPKSEATPADAAAAPVTGGNGDNKPSMEELGAAGGVDPANKSTVTSSAGEGKTIADVFGQQPELFAVVPLPWCPHLEGHVSPIPVSSPIDTRDPCSECGDTSENWVCLQCYQVLCGRYVNEHMLFHSISTSHLVVLSYADLSVWCYGCDSYVHHQIVFPAKRAGHISKFGCDDPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU56</accession>
    <name>A0A913ZU56_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055117.1">
        <property type="nucleotide sequence ID" value="XM_038199189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199189.1">
        <property type="protein sequence ID" value="XP_038055117.1"/>
        <property type="gene ID" value="LOC119727336"/>
    </dbReference>
    <dbReference type="GeneID" id="119727336"/>
    <dbReference type="OMA" id="VEKEMAW"/>
    <dbReference type="OrthoDB" id="6146826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF83">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="536" mass="60609" checksum="E6E499C154A5A523" modified="2023-02-22" version="1">MSRKSGEGMVRRGVDMCCVQESRWKGGSARWLGRRGERYKFFWMGTDDGSGGVGMLLAERWVYQVMAVQRVSERILLVKLLVGRRVVNVISAYAPQVGRSQEEKDSFWDQMVRVVSRLPQREGVIVGGDLNGHVGAAADGYDGVHGGMGYGDRNVAGERILKFGDAVGLVICNTFFRKTSNQLVTYSSSGSNSAIDFLMVRKGDHTMVKNVKVIAREECVSQHRLVVGDLALALVGARKVKKKQVPRLRVWRLTKEDVSERFRARVEELAEQAVMEESVDSRWSVPRNIWLQAAEEVCGWTKGEPRHKESWWWTEEVRNAVDEKRRRFNIWKSSGEKTDRLAYLEAKRISRRQVWMAQDAKRREFAADLRSGEGRRQFFKIAKQMAKERQDVTGASCVKDEDGNIVTDIEEWEVAQALKHTKSGKAAGPSGVVSEMMKASAGVSVQWMTALCNSILAEGRIPTDWQNSILVPLFKGKGDPLECGSLRAIKLLEQAMKVWERVLEVRLRMQVEIDEMQFGFMPGRGTTDAIFIVRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU66</accession>
    <name>A0A913ZU66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055127.1">
        <property type="nucleotide sequence ID" value="XM_038199199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199199.1">
        <property type="protein sequence ID" value="XP_038055127.1"/>
        <property type="gene ID" value="LOC119727346"/>
    </dbReference>
    <dbReference type="GeneID" id="119727346"/>
    <dbReference type="OMA" id="VGYHEIC"/>
    <dbReference type="OrthoDB" id="10011855at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18954">
        <property type="entry name" value="bHLH_TS_bHLHe22_bHLHb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000026">
        <property type="entry name" value="Basic helix-loop-helix family, member e23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF104">
        <property type="entry name" value="GH17679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="293" mass="32288" checksum="436603494DDABE62" modified="2023-02-22" version="1">MSWDDSYGRYVSQERSGVTGASDMVDTERQLNMASTLDKMIDTAVKMDDMRWGAGEDRQSHGLVGYHEICSDGNSSSTDSDEVHHHRLSSRDDARIREDGGSPEPNRVSDAEDEDHAMRQQPKKQTSGKLSNSKSSGKNSKHNRLSINSRERRRMHDLNDALDDLRSVIPYAHGPSVRKLSKIATLLLAKNYILMQANALEEMKRVVSYVNQSQLHISPPPPPPYFSGYPFPGYLSTSPTEKNPVVPASSSSGPPPAIVPAFPANRDSNLTAASPVLVHPIPVTKNSFTNPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUI5</accession>
    <name>A0A913ZUI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CASP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054736.1">
        <property type="nucleotide sequence ID" value="XM_038198808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198808.1">
        <property type="protein sequence ID" value="XP_038054736.1"/>
        <property type="gene ID" value="LOC119726959"/>
    </dbReference>
    <dbReference type="GeneID" id="119726959"/>
    <dbReference type="OMA" id="TSSICHF"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF17">
        <property type="entry name" value="PROTEIN CASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="253" mass="29228" checksum="7DC7FC6C244E28EE" modified="2023-02-22" version="1">MFSITEHYSELQAQHTEVVRTSDEQRQLISKLEKDLLSVNTLSTMYVRGEGEGQATPSSTEAGFAAEAVRETVPLGKSVSDNNQGAAESLLPIVSSQRERFRLRNQELEAENRQHQQQVNILKEETDKLRTDNIKLYEKIRFLQSYKKSKGSTGPDDTESRYSTQYEQRLDPFNSFSRKEKQRKYMNLSPFDKATLNMGRLVLSNKIARMIAFFYVIILHLLVFLVLYKMAYTSACKRDSAADCYHQFQEHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV06</accession>
    <name>A0A913ZV06_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055100.1">
        <property type="nucleotide sequence ID" value="XM_038199172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZV06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199172.1">
        <property type="protein sequence ID" value="XP_038055100.1"/>
        <property type="gene ID" value="LOC119727317"/>
    </dbReference>
    <dbReference type="GeneID" id="119727317"/>
    <dbReference type="OMA" id="QFHNADS"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036827188" evidence="3">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18051" checksum="288867F993D83D1B" modified="2023-02-22" version="1">MASCYARIVVGLLVLFLISNLQETSAARARGGSRFRSRSSGTTTRRTVYTYTSYSQGGLAYWKIILIVSGVLFAMALFFTCFRLWSAYSRRRERDLRSREAPRFENPIYRVHRPEGFEDETPPGGEDGVGDGLSDKNIAAAPPPPYDEAVKADEGAVDEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXV4</accession>
    <name>A0A913ZXV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056150.1">
        <property type="nucleotide sequence ID" value="XM_038200222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200222.1">
        <property type="protein sequence ID" value="XP_038056150.1"/>
        <property type="gene ID" value="LOC119728150"/>
    </dbReference>
    <dbReference type="GeneID" id="119728150"/>
    <dbReference type="OMA" id="PVICERP"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="96" mass="10989" checksum="673D7F2B53BF19B0" modified="2023-02-22" version="1">MGSVLVMPQSQEETEFLQKNVYHWFWINCSDLQVEGTWVCKDGTTDVEYRNWKMGEPNNHGGREDCAAADESGWNDVPCDDLSPVICQRPAPQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0H1</accession>
    <name>A0A914A0H1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056826.1">
        <property type="nucleotide sequence ID" value="XM_038200898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0H1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200898.1">
        <property type="protein sequence ID" value="XP_038056826.1"/>
        <property type="gene ID" value="LOC119728600"/>
    </dbReference>
    <dbReference type="GeneID" id="119728600"/>
    <dbReference type="OMA" id="IMITMYL"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="70279" checksum="741A455DA79B2C02" modified="2023-02-22" version="1">MAEVAERRRAVITTLFKEYDRDGAGELTPIQLQCMHANLRQGGVSLAQVQAAMSYCCLTDDACEPSELFATLQELDRRYFLLQDFRWEFALLDRLQQDLITEDQARFMFEAVHGQLFSKHHWEKFLKSRSVPGTGVSFAEIEVDLCNIPSREDMAYEEMEEQRQKGERARQIEEKKQAEEQARLKRLAKMEAQRLNKEDDVKKKKAVEKKKEEEMMQEREEEQRRKLEEARGKKEAEERDREDEDKRRRMKLDEEKERERQRELEIIEVQQALEAQKEVERKARELQEQEKKEQEKAKNAEEEAELAAAKEKEAEEEARKAKEAIKNASDAAAKKAAEEAERAAREKLKRERNERIRKDLKVAIKQKDRKLLDKSVAEFKKAKLADTDGDLHKAERILTQFKAKDDLVRAMEHRNLEELEQAINFVKKNSLEAHMPQEMVRANKMLLGLKRLKRLKDEILNLKQSTVAEIRSYNKPPRAVHMVMIGTYLLLGNKESTLKDWKGMQALVGKTGKEGLKRRVLQCDPTKVPVATAERAKHLLKEFDLEQVRDVSAGAAVFYAWTSATIEEVEDIVRQKEEGLEPTTHHGGPKTLKHELQSGTLTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2B6</accession>
    <name>A0A914A2B6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057993.1">
        <property type="nucleotide sequence ID" value="XM_038202065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057994.1">
        <property type="nucleotide sequence ID" value="XM_038202066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2B6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202065.1">
        <property type="protein sequence ID" value="XP_038057993.1"/>
        <property type="gene ID" value="LOC119729494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202066.1">
        <property type="protein sequence ID" value="XP_038057994.1"/>
        <property type="gene ID" value="LOC119729494"/>
    </dbReference>
    <dbReference type="GeneID" id="119729494"/>
    <dbReference type="OMA" id="GHCEARQ"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF69">
        <property type="entry name" value="FI18408P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="633" mass="70505" checksum="DE38D6060CEBFAE0" modified="2023-02-22" version="1">MEDKLINCEEEDIVPNGSENEANPSRHGNQNQPGTSYSSGDGQDSSTADVQEPHIRDSPLPEDHEPPTLSNRTKQHKHKACPLRSQFKLCKKRVLSSSTENLLGENGPRKSFKFCQGLMKRWFHISDKSGPEESSAASYEEDQNVFTDVISQVTGQEIRPLDTGECSTSGSQEENSSGRTGISGGLSGSCAEMLSEVTYMLNERSFEEEHQLLCTLDEAVPLTNRQDGSVCDLGHGEARTDDNLEDIDEYFSTSKLHLNRLPPQLLAHVFSFLTVPELLRTAAFVCKHWHRVSHFWTLWHQMRFRDHPNVTDGDLVELCSRHCSVGLLDLSDCLRITDEGLEKALVHCKMLRDLFLIRCSQLTDRAFLSIANHCANLTHIDVTGCSGLTDHALQSIAKGCPLLQKVRLKQCPLISDTSLQVIARSCPRLKVLMFMDSDKITDSTLEALASHSHYLEILCLQNCGIGPRGLAHVAKLHLLKKLDLSNLSTLTSDSVQEVARHCSLLDTLNLSLSRDVRDDCVLYVARLCKKLTTLFLISCTITDQALYGIGDNSALLEHLDVSWCSNVTDHGASYVSDRCPSLKYLGLIRCVKVSDTAVERMVEEHPGIHYSTFLLDSQRLIDKAREQGFVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A518</accession>
    <name>A0A914A518_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058947.1">
        <property type="nucleotide sequence ID" value="XM_038203019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A518"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203019.1">
        <property type="protein sequence ID" value="XP_038058947.1"/>
        <property type="gene ID" value="LOC119730224"/>
    </dbReference>
    <dbReference type="GeneID" id="119730224"/>
    <dbReference type="OMA" id="LKRIANW"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="138" mass="15570" checksum="D4ADAC1D1312A521" modified="2023-02-22" version="1">MAPIDMSGTWKNVKNENLENFFKALNLDIGVRTMAMAQKPVIEINQDGEVFRILTEGIKTVESNFTVGQEYTDINPLDDNEPSTYLAVWDGDKLRTENKSHPHAIHFDRELVDGQLVQTLTSGTGDKAVVCKRIFDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5A2</accession>
    <name>A0A914A5A2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059032.1">
        <property type="nucleotide sequence ID" value="XM_038203104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5A2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203104.1">
        <property type="protein sequence ID" value="XP_038059032.1"/>
        <property type="gene ID" value="LOC119730259"/>
    </dbReference>
    <dbReference type="GeneID" id="119730259"/>
    <dbReference type="OMA" id="PCYDRIV"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="602" mass="64449" checksum="A4575B130EC37EB9" modified="2023-02-22" version="1">MHLHSLQSLKISSVPCLSQLHLYECDLTNSDILPLFQLISAAGSVQKLILNGNNLQGLQPEEITAVPSLVELHLYDCGLTKIDIQPVFSLLSATGSVKTLVFEGNHLQGLQPEEITAVSSLTELRRNECGLNRHDIDSLFTILSSAGSIKTLTLKGNKLNGLQSATITTCPSLSELNLCECGLTSSDIKPLFRLLSAAGRLKKLVLKGDKLHDRKPSQITAVPSLSELHLDECGLTNSDIKPLFSLMSAAGSVKTLALKGNNLHGLQPKGITAVSSLTELHLDECGLTKSDIKPLFSLMSAAGSVKTLALKENKLQGLHPEGITAVSSLTELHLDECGLTKSDIRPLFSLLAAAGSIETLDLQGNNLHGLQPEGITAVSSLTELHLDDCGLTNSDIKPLFSLLAAAGSIKTLALKGINLHGLHPEEITVVPTLSKLHLHGCGLENIDIGPLFSIMSAAGSVETLVLEGRNLHSLQSGKISAVPCLSQLHLYECDLTNSDILPLFQLISAAGSVQKLILNGNNLQGLQPKEITAVPFLVELHLYDCGLTKIDIQPVFSLLSAAGSQQAAYGHLFFKETIYTVDIRRRSLLFPPYLNFISMSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAK7</accession>
    <name>A0A914AAK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038060471.1">
        <property type="nucleotide sequence ID" value="XM_038204543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204543.1">
        <property type="protein sequence ID" value="XP_038060471.1"/>
        <property type="gene ID" value="LOC119731366"/>
    </dbReference>
    <dbReference type="GeneID" id="119731366"/>
    <dbReference type="OMA" id="MHYASTY"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038154211" description="Metalloendopeptidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="83"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="324"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="491"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="605" mass="67654" checksum="6F96C9F807DAFAED" modified="2023-02-22" version="1">MSNTAMKWFLHVLIYFAITKLALSGPDTPILRPEVGDDEGPHPEPPEQLESPGTFQSDMLLTHQQAEDIVTSVKGMMALQKRRAVRTGYWPDAKIIYQIDENFGATMVTKINEAMEWWRQDTCVTFEEYVPSSTPDSDHRVVFKKGYNGCYSDVGMIDDFPQHIHLQEDTCDVTGTIAHEIGHTAGWWHEHARIDRELYVTIRYENIQDGKEKQFVMHESESYGVPYDTESIMHYASTYYSKNDFVTIEPHKPLEAFKMGNRKYFTFFDKKLANLMYNCSGVCTEDLQCENDGYVGQDCICHCKLGYSGENCELYTARDEDDPCYKEFEAKFDSDQQLNSPGTPLPYEPMLYCPWLITAPEGSTVILTFLFLDTEGGSCKSDYVKVRSGTDIFYGGDSYCGQTLPEPIESVGNQMIVIFKSDGSIQGRGFRAQYRANPAKTIPTTPEATTPEATTPKATTEATTPPEEPTTQLPATDKPIVPKCGDVEGSCGGVFNVDSGCIASPNFGNGEYNNNEECVYRITVDSGKRVELRLEKLDVEYQDECTWDRVVVIPGQTHGSVRVCGESVPEGSFVSLDNTMTVKMISDALKTQGGFSASFQGITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB11</accession>
    <name>A0A914AB11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Saposin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060559.1">
        <property type="nucleotide sequence ID" value="XM_038204631.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204631.1">
        <property type="protein sequence ID" value="XP_038060559.1"/>
        <property type="gene ID" value="LOC119731463"/>
    </dbReference>
    <dbReference type="GeneID" id="119731463"/>
    <dbReference type="OMA" id="ASIKQEC"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114268" description="Saposin" evidence="7">
        <location>
            <begin position="16"/>
            <end position="2435"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="247"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="349"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="445"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="629"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="727"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="824"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="923"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1394"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1487"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1580"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1673"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1768"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1861"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="1948"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="2039"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="2132"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="2224"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="2317"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="9">
        <location>
            <begin position="2399"/>
            <end position="2435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2435" mass="267215" checksum="B015F53856A9F14D" modified="2023-02-22" version="1">MKLVLLLSFLAAASAASIGSEKCTWGPAYWCDHPLKAKECGEGATSYCIANDWAQLKVDDDSACDDCKMFIAAVKDVLNNSTVQTEILSVVKELCNKLGSEATTCQLIVDLYGMKFLEALITDLDASQVCMLLELCKSATPNDVIQGPLLVTVLDPDVCAECKQIFSDLDDLLSNKSVQQYVFKEVIEVCEQAGAPADLCKMYVNQYGPEVFQYIIGLLNGDMLCSELGVCSSITRFNFLKKVSNLQAAPCTDCKQIFSDIDDLLSNSAEVSSFMQQEVLQYCLKLGLFPNDVCQELDKYTPVFMKYIATLLDGDMLCSELGVCSSTGHAGTFNPKQLFMKLIKVSKLTADPCTDCKQIFSDLDALLSNSSVQQYVQKEVLQVCNDVGLPGDICQDIAQYVPQVLNYLVGFLDGGMICSELGVCTSTPTLNLQQSLFLKLIKDSDETLCQACGDLLNGLTSFFGNATVQKYALMYAIEYCQVEGYSKDTCTQAVNQFGPTVISFIIQHSDKVCNIFMQCPSYNKPVPNGDLCSSCKQVFSGLATITGNSTFQKTVQTEASLFCRYEGHSTAECEQFVNQYVGKFVQFVTSQLKEPVWCEIIQVCTPSQDFSAVSKPQAMSRLMQDPPSNGDTCKECKAIFSDLQDILNNETVQTQLFSTLTKVCVALGIAPDTCTTDIGEFGPLVLQELIPLLDGSTICPQQGLCAAGSLYKLGRVVSSVQQVTKSNGDPCAECKEIVMDLLDILNNQTVQKDIFNKAIAVCVALGGSTATCTGVINNYGPVVLSILTNELTPSLCTMIQLCTSSVEHVQPKPAAKAVMVPPSDGNVCTECKQMIADIKDILSNTTVQNNLFSTLTKVCVALGIPSDTCSEDIMQYGPVVVQFITAELDGTVLCPELQLCAPGVMAKLIDAVSAFRKIVVSANGNTCTECKDVIMDLSDILGNQTVQGNLFKQLIAVCVALGIPSDTCSSDVNEFGPIVLQALIGYLSPSLCPGLSLCSSAIPEPFHLPKQMPALELVPAQPIFNPVGDDPTNCLICEFLMDVLGAVYPTGATSAQLETLMYTSCKSLPTEELVKQCNAFVTNWADRLIEELVALDFDYDKACTGLQICPGIVPEPKAQINDTTCIMCEFVMDFLTSFHPQDFTKVDIQSAMNKACSLQPPGSKTECDGFVSQYGAQIITLRMDKTPFEDVCMKMNVCPDLVSAQDRFDDIFDCLECQRVKAYLVQVIKPHVTQQQVGYALDAVCLLIGGNVKGCLEFMIQYRSDVAGYLLSGKPVDMLCKGIGVCTAAAKPVPENTQVGNALECEVCKLVMGEIEVLLKKNATEKDIEKFLDNICNVLPSSLKDACDAFVTKYTTAIIDLLKSIPANGICQYLGVCTSSSAPLVQTNLVHVGSSVQCDICEYVMDLLDVLIKENATKTDIEHFLENICAVLPSQLKTECDMFVKEYVPEILQLLATFPPDQICKELGLCTSSKASLAQSNHVQVGSSVECEICEETMALLEGFLKQNTTKADIENFLVHICDILPSQYKTECDMFVKQYVPEILQLLSTYPTDEICKLLGLCTSSKGPVAQSHPVLVGNAIECEICEYVTGLLDAFLKENRTKADVEHFLDNICDILPSQYKTECDMFVKEYVPEILQLLDTYPPDQICKLIKLCSSAKAPVAQSRPVLVENAIECEICEYVTGLLDAFLKKNRTKADVEHFLDNICDILPSQYKTECDMFVKEYVPEILQLLDTYPPDQICKLIKLCSSSSAKAPVAQSRPVLVGNAIECEICEYVTGLLDAFLKKNRTKADVEHFLDNICGVLPSKYKTECDMFVKEYVPEILQLLDTYPPDQICKLIQLCTSAKAAVAQTNHVQIGSSVECEICDEVMKLLDVFLKENRTTADIEKFLDNICAVLPPAFAKQCDAFMNEYVSQMLKLLAQYPPDQICKLLGLCTSSKDLEDVKESTECILCQLVMTEVDKLLDGKTSQAEIEKVLEDVCSLMPTTIRTECEEFVKEYAPQIIQLLLQFVTPTKVCDELKLCTPSQVEAKVPETVGGIACGPCEMVAEHVEIILKEGSTQKEIEDFLKTEVCPKLPGDAQKECVSVVDKYLPEILKLVTSMTPEELCGLLGLCSSGDAMDKMVDAAIHSTAECMICDLIVKEMRTGLSQNSTEAGIQKFLDTVCSKVPLSTVAKDCQEFVNDYTKPIIQYLLAEMDPDNICDFLKVCDQSKITSPFGKVNSDTFCLVCDVLFGILETQLATNKSFEEVTDLIEKVCPLLPESLNEQCKGFLDMYGPVLLKLIVDSELSPNEICKDLGLCTSFSLLQPKLMFTSGSVECDACKELVTVAEDLVKENEDKILETIAKICDLFPKNDQQQCQNYIEVYGDYILDLILEGYLTPDAVCKDLKLCSQSIKSLPPANKCMQGPVFWCASMDNAKLCNTVEHCRRHAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABT8</accession>
    <name>A0A914ABT8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061312.1">
        <property type="nucleotide sequence ID" value="XM_038205384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205384.1">
        <property type="protein sequence ID" value="XP_038061312.1"/>
        <property type="gene ID" value="LOC119732019"/>
    </dbReference>
    <dbReference type="GeneID" id="119732019"/>
    <dbReference type="OMA" id="HYLIESC"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042803">
        <property type="entry name" value="TCF19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="56276" checksum="8FBD97EA91D040CB" modified="2023-02-22" version="1">MAGSASAGEKCSFQLRRIGAPATCKGIKDSYRLQENKMLIGRHLSAVDIYLNSSVNKKLISRQHAELWIECHHDTQVVYLLDKSTNGTFINDIKIVGKVRLTEGDTLTFGHTQGIRIQPGMHKQQPKSEFRFVLEKASSENTPPHSASSFISDRQSPSACRHQHSPDFETNVSTSTSMELLTHQDHYQEGAVNGQECFQSLPCTTNVKLSPVVCQSSPKICTVDCNQLKCDFRDDTVAALSAEPFTTCHQQGPVHQKRTEEFSEDAEKTKLHNTETDNELLELTSIISAKAAKFDSSDSDRDLEELLPVFPKTQQHLPPSKCIYPRTYPDAIALENSRYEAFKLESIPRSSQVLSIAQSQLSSDDDTYSSSACHHVDATHANHLPTLSTSLVPQFTSKQTSPQNIDGAKCKNRGGHAVTNRKKKKRRQGYLRTSTKSNSGVDAIAAQDLEAEVCDSYECCKPTDKTVDWVQCDRCDKWFHVACVGCDYDTVKKDSAAFNCGCTHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACA2</accession>
    <name>A0A914ACA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061550.1">
        <property type="nucleotide sequence ID" value="XM_038205622.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205622.1">
        <property type="protein sequence ID" value="XP_038061550.1"/>
        <property type="gene ID" value="LOC119732196"/>
    </dbReference>
    <dbReference type="GeneID" id="119732196"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036995450" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1573" mass="175211" checksum="F9313E4FF6ED08DA" modified="2023-02-22" version="1">MAFTYITIILLTLGLCEATYKICPANSVNSTHSTFGAVNNVQRGVWHQLACRSFRPDEAISRVIWYKNDSSNTSPQLLITYGYEADLPESDRYAFGTSGFSLVIKGVEDSDEGGYLCQVVPRDTKDRLDQIVIRVIGDTFPGGSSQASSTAVLQRGLRQTLPCECASQTPDVVYWSTGEGVTTDTQIIGARFSDGATLQIQHGADYSFGGDASFTVNSLNDVQDTQIFWCHVFQSDGSLRNCLTDVQVSDEVESAGDALKASERSFYLRNDTQQILPCLSWTPGNTACAVEWSKLDNPDRQVLSYNLSTGVVDSSPEFDLASDFGLVIQSGDDDHAGVYRCAVGDENQIDVEVRVIGDRFPLDGGSAKEGDSVTIKPETRFSLQCPALSDISLTTKATLFWSFGANDAESTTVIGTLNLPDGLKKMYDLGKDCLGISMEGALLFNNCSQDDDVRYWCHVFPANDNLIRSYVDVLKESKFMPSMKSHLGSSTLIVIAICVPFFVIVLLGIVLFLICKWRRQSSHSREDKEKGDYKRLHKQESVPEFDLKTLAKKIKAFVISKMGRIPITLWVDGDDALSAPIDTVYKALEMFVIVSHGGITVKYRLDSESGIFDDGIPELASRHAIIQGRRGCGKTTFLYRLIYDWASGREGALWGSDQIVVLVPARLLIKAKTIGEAVVEFMLQKDAHISAESINAHFARDKSNLTILVDDCNYQHEIDAVMKVMTDNKFLGCQLALTTRNAKLAKGASRKQKMRHVTITGFTLSNAIEYINVVLDDAEDRKKSPPERKSVKSDAERESGSTVDTNIQQNLPKTGESPTVSAPPETHESPVTGTNREKTEALETTRPRKRRNLHRYLGQEILQPDILGLPAVLVALCQMSIWTKEDAFKHDITMANMFFRLVKCMFDRNEGLEVGVTEGNQLSLLTKEQQNVLAELGKVHYNYSRPVDNYDFLSSPEKTQNALKVAKQVGILLPFQVETKVKSTEHNTEAGLSEVEIRTGFLFCKRKQTQQNVAERVPIAQDTELTPLTSPKDKQVCFVLEIIEQLCVAVFITQTRGQVTGLEEILQRFSNVFQFAIQDNQCEREVLLNCCANIINKGPSQVRPLHEVLHLQKSIELCLQLNFEGQCEGALNKKLQSIIPDERVRLIGISSYKLRLVLYLFQHAQPDDKSKLNVKSVELLRIGQYDWSEKGSEKKTTVQTETEDSQTATTVIHEGTVRASQEETKKLPNHPLVNHLPESEDDNEAQEAVKSSKTEPQLDSGDQPNLLQPKLGASPTEDDGNEYKSIDSSVDEGIASSFDVIDSKKDLPVPKKLRERIESSNKDMPQFPPDQSDISVLHTVQSFGLQEILDSQAGECYSSGAASDLARYLPRLVKLESLVLVGTILSSDAICELAKSAHKLTNLKKLDLRLNKQFNDRAFVTVTDLLLCKCRKLTDLRLSLYRVTIKGFDKVQTEMKGRELFWKRLKTLYLLHGSPAEKFVGFLSNSVKYFHCVECFHLSATDKSEEIQDKIQGEFEQNVTNPRIMPHLEDLDIGNMETLKARLASLKLPKKEKGSVISNLFGTTVTDLGKKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACL1</accession>
    <name>A0A914ACL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061582.1">
        <property type="nucleotide sequence ID" value="XM_038205654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205654.1">
        <property type="protein sequence ID" value="XP_038061582.1"/>
        <property type="gene ID" value="LOC119732221"/>
    </dbReference>
    <dbReference type="GeneID" id="119732221"/>
    <dbReference type="OMA" id="FARIDHG"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002248">
        <property type="entry name" value="Cl_channel-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF158">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01117">
        <property type="entry name" value="CLCHANNEL6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="830"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="908" mass="100583" checksum="B77AA8F7BEE019DA" modified="2023-02-22" version="1">MDSLCGCCPNCRRRDRTSSTRSGGSDDVGLLTGDYSQHGGNNWLPVKDYESLDYDICHNAPYQEMVENDNTWMSRHLGLMRWVVTALIGVGTGLVAVFIDVFVKYLSDLKYSTVSDSILVCKKDGCLVLSLLILLGFGAGFVLIASILVAIEPIAAGSGIPEIKCYLNGIKVPHVVRLKTLLSKAIGVLFSVSGGLFVGKEGPMIHSGAIVGAGIPQFQSITFRKLNFNFPYFRTDRDKRDFVSGGAAAGVAAAFGAPIGGVLFSLEEGSSFWNQMLTWRTFFCAMCATFTLNFLLSGLDYQQWGALDQPGLIDFGIFDRCEKGKTTNCDPWTALDLLVFIVMGFVGGLLGALFNFLNTKLTIYRMKHLGSRRKFVRVLEAILIVMVTASIAFGAAMTLGQCKKLPSSNAQEADNRFVPWSSNVSSGNGTEVTFFCQDGYYNDMATLFFNSQEIAIKELFHEAGKFSLQSLGIFFGLFFLLACWTYGAMVPSGLFVPCLLCGAAYGRIVGNILNEYTGFANISNIYSGTFALIGAASFLGGVVRMTISLTVILIESTNEISYGLPIMVTLMVAKWSGDLFNKGLYDIHVELKGLPLLGWEPPRKMDRLRAHQIMETRLTYIYPHTRVRSLISILRTTQHHAYPVVTENLHTSAAAAAAPPNSADTAVASKNILYKRESTLSRSDEQRQRSSSVRSVEMLRVHRMSRLAADYNLARNRHDSAENTEDWDRVSLRTDPSGYPSWLADVMSLDDNEDTRDDCRPLTFHGVILRSHLVMLLKKKVCYAENTSSLCQEELSYGELTEDYPRFQDIHDIDINAINHNKIMDVTSFMNPCPYTVSPETPVSKVFNLFRTMGLRHLMVINSCGEVLGIITRHNLTEEFLEEKLEFYGDAPHHCRNSDADSTATPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACU1</accession>
    <name>A0A914ACU1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TASOR PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061286.1">
        <property type="nucleotide sequence ID" value="XM_038205358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACU1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205358.1">
        <property type="protein sequence ID" value="XP_038061286.1"/>
        <property type="gene ID" value="LOC119732009"/>
    </dbReference>
    <dbReference type="GeneID" id="119732009"/>
    <dbReference type="OrthoDB" id="10664397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056242">
        <property type="entry name" value="PIN_TASOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24630">
        <property type="entry name" value="PIN_TASOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR PIN" evidence="2">
        <location>
            <begin position="103"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="289" mass="31866" checksum="36ABFD71088207EE" modified="2023-02-22" version="1">MIPVVQGTAGGLDSNQNSQQLSTKVSCLSTDGSDTETTSAITGKPIQAEWDSSLTKEESGGFNCSGGQSESSSYKQPSGPSVDRLEVGPTKGQKKASSSSLKGIVIPDELLLMTCIPDELKALCKALQRRSSWGRQQHWRILLGSEIVVKMDQVRQQAHLNSQLCYQANAVLRILSRYRSLGLVHLLPGQQVDGSLSVKQQIDYIHKLRIAVPNSQQCRCIWLTDLPLSNSDLDQFKGRNINVYNIKTLLAKLLPDEPVQQAREPFVHDQSQDPPSATRGRAVDNFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACY6</accession>
    <name>A0A914ACY6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061209.1">
        <property type="nucleotide sequence ID" value="XM_038205281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061647.1">
        <property type="nucleotide sequence ID" value="XM_038205719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205281.1">
        <property type="protein sequence ID" value="XP_038061209.1"/>
        <property type="gene ID" value="LOC119731957"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205719.1">
        <property type="protein sequence ID" value="XP_038061647.1"/>
        <property type="gene ID" value="LOC119732267"/>
    </dbReference>
    <dbReference type="GeneID" id="119731957"/>
    <dbReference type="GeneID" id="119732267"/>
    <dbReference type="OMA" id="WIASRPV"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22879" checksum="6B11D9D7B947D3D2" modified="2023-02-22" version="1">MPSYKVIYFNGRGYAETTRMMLAHVGQEFEDVRYTQEEWLEHKPNVPLQQLPNLEVDGKIIPQSRAIHGFVAREFGLNGASNEETTKIDIILGTLEDISRHMQSGETDEEKKKEKLAEFYAQTAPKYLTGLEKMLADNNDGDGFFVGSKISRADIFFYVVTEYLAEDELKKYPKLVALKERVAKDANIAAWLAKRPQTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEK6</accession>
    <name>A0A914AEK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061794.1">
        <property type="nucleotide sequence ID" value="XM_038205866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205866.1">
        <property type="protein sequence ID" value="XP_038061794.1"/>
        <property type="gene ID" value="LOC119732389"/>
    </dbReference>
    <dbReference type="GeneID" id="119732389"/>
    <dbReference type="CTD" id="138050"/>
    <dbReference type="OMA" id="ITIYCGH"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038008650" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="4">
        <location>
            <begin position="253"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="645" mass="72658" checksum="90FBF1C035CBFC19" modified="2023-02-22" version="1">MSASWIMLLSKFLFFAVAFCTVHAVDAPTGNVDVESPHVSTGFSQSTRHLPKDSSLTSSRHDAFGYHSIKYDTAFLYVVNNVPDNIAVWGQSKECYKCKLIKLAEVSGNTTKLLYLDTWWELTLALTHSNLPVYNSSSICCKLLTKHFGENSNYSLFVNENKSATDNSDVCVYSKNREPDNANIPIYVAIGVYALIAVVYGILNFAYTNGVFNSVFNWCVTERVVNSDLGSPPSRQPVTNNASFSKDPTKPRRLKSLDTFRGISIVVMIFVNHGGGGYWFFKHARWNGLTVADLVFPWFVFIMGTSMSLSFSSMVRHNVSRWAIVKKIIRRTIILFGLGIMLDGKTDLSTFRVPGVLQRFAISYLVVASLHLTSAKPKIEDYRISNKYHLMFRDLVDYWHEWLVVIGLMVVYVCLVFFLPVPGCPTGYLGPGGPLVMHQPGNVENCTGGATGYIDRWILGEKHLYSHPTCMKVYHTTLNYDPEGILGSIPSIFITFLGLQAGKILLLHQYHGSRIKRLLIWTLITGGPALLLCEVSQEEGWIPISKNLWSLSFVLAMAGTSFLLLTFCYIMVDMKQWWSGVPFFFAGMNPITLYCGHEVLMDYFPFSWDPVYGTHAELLAMSLLCASIWSALAYYMYRINFFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFG3</accession>
    <name>A0A914AFG3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062241.1">
        <property type="nucleotide sequence ID" value="XM_038206313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206313.1">
        <property type="protein sequence ID" value="XP_038062241.1"/>
        <property type="gene ID" value="LOC119732678"/>
    </dbReference>
    <dbReference type="GeneID" id="119732678"/>
    <dbReference type="OMA" id="IHEMHHA"/>
    <dbReference type="OrthoDB" id="10533395at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="614" mass="65680" checksum="AF4D0F7A68F2EBD9" modified="2023-02-22" version="1">MNARRNSGPVYVDAYGGIAAVFSGDMDRYRAKDKNMEAPVRYKRGKRRKSITVTRKETMPAIRSQSPAPLPPRPRPMKRSDSSISRVSVASEFATIAEDAVCDDFRGEVRQSYPPTAGRRVSFSSASETPPALYNRRSSSSSLVGKSSYDEPPRRRVSIVSLQRSDSTVSSLMDFNPRRLSTVSDAVVIRKTPKPWRRNSADGYVGHIRRASADGNTSMSGRRSFPPQSTSRRYHQASGPAYQSYPPPDMGEKSRDVFEGSMADRDGLSYEATLRRASLASIHEMHHAITLLKNQKALAKLQKAQGRNFQDGSTGGYGSRRSSLRGSSPRQSVGSGSSRARGNSTASLDAHLRRLSISTSIQDMHQQMTLIKEKQLVKRLNSRVQFSVVEDAARPSESRRGSLASGRRRSSAGGSPISAASMSSMTGGRSRLGSQDSDSYSSNSDYSSSSGSSSDYSGSSSEYSESDSEDSQSSSDDATSSDSDSDTSSDSGSEVSGSGLSSQEAHGSSDDDRSVASSAGTSSTDTDSGNGTLSSSHGSKTEGQPKGIQDLAGPSGLGRMGRVSPKSPPHTDTRENHFDFSGTHHPMVQKGAGDNGAQQKVMKGQATSKACVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFG9</accession>
    <name>A0A914AFG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062124.1">
        <property type="nucleotide sequence ID" value="XM_038206196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206196.1">
        <property type="protein sequence ID" value="XP_038062124.1"/>
        <property type="gene ID" value="LOC119732611"/>
    </dbReference>
    <dbReference type="GeneID" id="119732611"/>
    <dbReference type="OMA" id="YTCYTSC"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="131" mass="14582" checksum="617DD06D56813969" modified="2023-02-22" version="1">MEDILTLPEDLLSALHFVFKAPLLQALDLVDNKSVTKITCPAGRIAFQVLGSSGIPYICLPSSNFCSCQYYSFTVLKRNDVDLCKHVLAVLLSCAMEVCQEQQVSNDRMTQTLTPGHSEPEDEQPHHSRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFR2</accession>
    <name>A0A914AFR2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062568.1">
        <property type="nucleotide sequence ID" value="XM_038206640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206640.1">
        <property type="protein sequence ID" value="XP_038062568.1"/>
        <property type="gene ID" value="LOC119733060"/>
    </dbReference>
    <dbReference type="GeneID" id="119733060"/>
    <dbReference type="OMA" id="NAARCET"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="232"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="35790" checksum="6A190981F78372FA" modified="2023-02-22" version="1">MLVNWKLAQATSVEQQMTTLRTALEKIGRADIAEFPQVISQTEETAGSGISHTKETAGSDPETTVSNVRQAPVNPQPPLQEYRMDRKPRGLCLIINNNTFDKPLKPRPGSEIDTGKLDKLFTKLHFKVEVKENLTGSVMCTLFQDVSQSHRHKNYACFACCIMTHGTLDEVWGTDGMPLKINWIQGLFTADSCNSLTGKPKLFFIQACRGSSHQIGVQEMETDDPGDIVAPTPNTIPNEADFLVSNSTVPGYVSYRHPRQGSWYVSALEDAISEHHNTTDMLSMLIIVNQILCDRNAKTNQGIGKQVSTLSCTFRRALYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFW0</accession>
    <name>A0A914AFW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062259.1">
        <property type="nucleotide sequence ID" value="XM_038206331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206331.1">
        <property type="protein sequence ID" value="XP_038062259.1"/>
        <property type="gene ID" value="LOC119732694"/>
    </dbReference>
    <dbReference type="GeneID" id="119732694"/>
    <dbReference type="CTD" id="56521"/>
    <dbReference type="OMA" id="LLCEYKV"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="172" mass="19876" checksum="BB3E382149E9E1BD" modified="2023-02-22" version="1">MDEILSGEIRDEDDFYKLLGCDELSSTEQINTEFKLKARTAHPDKNPDDPDAAQRFAKLQRARDILTDDQKRQEYDLWRRSGITIPYDSWISMKGAVHTSMHWAVKKKKDLMLEEDPENVPESPEFSDTNVPPPSRTVAPPSNYGHSRPFVPAGWTREPANDILQKFRNYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFW6</accession>
    <name>A0A914AFW6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062401.1">
        <property type="nucleotide sequence ID" value="XM_038206473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206473.1">
        <property type="protein sequence ID" value="XP_038062401.1"/>
        <property type="gene ID" value="LOC119732877"/>
    </dbReference>
    <dbReference type="GeneID" id="119732877"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037939281" evidence="2">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="234" mass="25872" checksum="0E229B959BDDDA3B" modified="2023-02-22" version="1">MSSAWKLILLRCGLFDVDAYTDKTICPAHRYKLGLSWTSSRKCCHLLHKVKGKPFRVGNKATSREMFDRWGILITVGTGICRGCISKHKQAVTHQTAEQLPPSDVLSKEQEEQQCTISDFTSPAGVPSLQPTDTECTSVHEHTSESSSTDGDITKDVHLTLLGLQPPRPKNVELQSLNTFLTQGGMSAVDGQLRLSLEEASDSTIRYYRRKAKEAFGLVLHCLAPGQEDGLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGH2</accession>
    <name>A0A914AGH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062806.1">
        <property type="nucleotide sequence ID" value="XM_038206878.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062807.1">
        <property type="nucleotide sequence ID" value="XM_038206879.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062809.1">
        <property type="nucleotide sequence ID" value="XM_038206881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062810.1">
        <property type="nucleotide sequence ID" value="XM_038206882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206878.1">
        <property type="protein sequence ID" value="XP_038062806.1"/>
        <property type="gene ID" value="LOC119733280"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206879.1">
        <property type="protein sequence ID" value="XP_038062807.1"/>
        <property type="gene ID" value="LOC119733280"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206881.1">
        <property type="protein sequence ID" value="XP_038062809.1"/>
        <property type="gene ID" value="LOC119733280"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206882.1">
        <property type="protein sequence ID" value="XP_038062810.1"/>
        <property type="gene ID" value="LOC119733280"/>
    </dbReference>
    <dbReference type="GeneID" id="119733280"/>
    <dbReference type="OrthoDB" id="6343950at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="207"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="864" mass="96772" checksum="6D19B204EF8BB06C" modified="2023-02-22" version="1">MAEPPAKRARRQNETQTNPGPSTAATQQLPADGVRDDQKTTQSGSGHPSQQEPTPQPTQQLQPRPLSSHDYPQQSGASIGSIGTVSGSQNPVIVGSSGVNITYNSPLEGPEITSLQGPGTFEDLQHEIIDNYKQTATTIPAHPILETRYVEIDKFFIPLHLQKNIPDKTKSVRSVRLPEGKIFLDEALYDILNSLDDLFNQEKVKEIKILLVGGAGTGKSTLLVKVANSCITLRSKPLLGRFDLVLWIKLRQMQQSSCVLDAIFDQILAQNTKLRRQEVKGFIDDHESGIALLLDGVDEIPSHVLQSKEGVYRVQDILHNRVLTKSFVLVTTRPHMVDYVLGGHPNYARVETSGFTPRDRDQYIRLNHPDDADMGEALVSYLEDNANLQEISVVPVISQMLCIVWKNQKSLPMRITELYKEFAVALFKRRNTEMSDKQLMSNMMSIIDGLGRVALQGLLDSRGERLMFDETEFQNCQSCLAEGCRVGFVQRETFTIGLDVKVLVTFPHKSIQEYFAACHLVRLLDGFFFGKTKFCRQLKRIGTHNVHEMEYLLRFCCGRSGKAAGLILSHIKKMQGDESKLQRLARLLLLESGSEELATKLVRPTEVDCESNEDLKSLSYYLQHVTPPLEGTFFHMYVRKQELTFLRGILLSDSMESAGLIVVHYYLSEQEEEELSLIAETLGGVDEQCRAQLNITVFILAKSWFDVGRVSHSFFCMHEQIDGLGLVMHQRSPDEVVDLLKALEGCRLDMFALYGTNLHAQVRHVSHILSSLTVLQLDACRLVDDDVKDLISILPAGHGLQGLNLDGNAFSLDAVRALTHHLQGLPKLYYLSLLNIGLDPELVRQVVSQDLPHLTETQEGKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGK8</accession>
    <name>A0A914AGK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063120.1">
        <property type="nucleotide sequence ID" value="XM_038207192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207192.1">
        <property type="protein sequence ID" value="XP_038063120.1"/>
        <property type="gene ID" value="LOC119733822"/>
    </dbReference>
    <dbReference type="GeneID" id="119733822"/>
    <dbReference type="OMA" id="WDITIHA"/>
    <dbReference type="OrthoDB" id="5976369at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6589" evidence="3">
        <location>
            <begin position="527"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="609" mass="69357" checksum="838F20803BB8B4F1" modified="2023-02-22" version="1">MGHVQLTKRVKTIGWDPVRIVSPNFIFVVNIIFYINIIFFNNIIFFINIIFFMSPISNSFISVIFFVIEIFLNYTSSNQRLLSVEEFNGLSSIVSSRDPDSIANVMWGIKPIQSAVKHLSLAEVKANCCSLQRCSILRKCDFSDHSNFNWRDILQEMDKQCPFLLDVLVTTASDDSHVFEDAKVPVICMVYGMLLYQRSCRIGRLQQLFTILLSRSAAKKEIYREFQRVGVCQSFTQKDVLLNKIGGHFNEEAMELVKKGSKFQIIGDNFDLRVLRHDMTKDAKNIDLHYFASTIVFDRISFEQLPDDKPTRPLQQCPISSFVPNEDEINTLKKSYKILVARDIVECCPALAFMKSVIPHHIKHKYSDITKEKSALFTQEILPCNENNYGEVVQILSRYEEWVHNIFRKESATPLVEKQTEVSVNKLDACFESKILLSHTNGIITGHGDGDADFCMLGADELTFHDHVHTKDLQDEGVGICSGTDNYVLQETGAKSDTPASCPNVQSRPDQPGSHMMQVDPADPLQHVHIPVGGDQLTRVRLAGAKDLRAGVHTARQRFDHLYPFICEIWHAKKAFLNVRFGLCIFLYFPKSTHDNKICSLPDLVLEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHR4</accession>
    <name>A0A914AHR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062924.1">
        <property type="nucleotide sequence ID" value="XM_038206996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206996.1">
        <property type="protein sequence ID" value="XP_038062924.1"/>
        <property type="gene ID" value="LOC119733420"/>
    </dbReference>
    <dbReference type="GeneID" id="119733420"/>
    <dbReference type="OMA" id="TICHEIQ"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038069774" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="7">
        <location>
            <begin position="33"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="9">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="591"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="100443" checksum="E7A44F32D7B56AB9" modified="2023-02-22" version="1">MMASRRGSRCFLLKRLLLVMMYSACGLQNVAGQHLCGESRTRCSVGCLDMGSTGRELCRCDPQCALYDDCCEDYWTNCVNESSSESRIRPILHSEYSEYFGCVSPIDIDSFYNRFVVVDRCPLDWPQGVTKSRCESTTLSRQEKLLTLFVNGPGDIVFKNVYCTICHEIQEQQLRPWTVELWRCQPAEGESRPVQIGGNPDYTTCSKFRMKPPSSMLYHPHRCYPSFVDSCPANTTAQADQVQLCEDYTSLLFHKYADVVYKNVHYLNCSSSGSLGIHDVFCKPRTGINDRFDPNRSFTLLFDFTSRTVHSVTNEGTTSRTHSTPALIRNCSRWQIYDPFLDICQDLTCRDGQPPESSSGMCLDAQPKKALGQSNLSEDCLENLIAMNSSEMSTSTDLWTSADIVDEGSDSPRHILNIYTSFALADRIQNALDLKLSNVTDAGSFASLLCSKASSVILVASDQSETHKEGICEGFSFGNISFSDLLVLDGVFSVNIGGFVYDQHEFMHETEYFFDINDASVIRRQSVTLCNPFVGSRRCSLLILYPDDFFQSTDGGALIHAETGVPFLVGEYWLLPDGTVRVCQIVWSHVLAYVSYVGTCCSVFGLILGLVTYGVFPSLRNTPGKIVMNLMGALLMAQVFLMFGTDPQSWFCVLRAVLLHFCWLSVFFWMSVWSCDLAYNLKCNVRPARPSRRGGSEGWKVLKLSAFAWGLPAVIVVSCFLASQFSNDRLGWFQYGGSSCWIVVPFHSAIVFGSPIALSIAVNVAMFAFTIHTVIANHRRLVAARMAKQTKTTVLMCFKIGMVTGVTWTFFIVANVVREPALWFISVLANSLQGALIAAIFLLRASVRKLWREKLARAYARARACRRSCCRRGAGDDQKRDSDICLSSCSGSLDKGGVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIE7</accession>
    <name>A0A914AIE7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063311.1">
        <property type="nucleotide sequence ID" value="XM_038207383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIE7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207383.1">
        <property type="protein sequence ID" value="XP_038063311.1"/>
        <property type="gene ID" value="LOC119734002"/>
    </dbReference>
    <dbReference type="GeneID" id="119734002"/>
    <dbReference type="OMA" id="NKGNHSH"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="822" mass="92466" checksum="5A911440DE0C6D1F" modified="2023-02-22" version="1">MHSNSSLGEPQQLHIVDGPQSLEKDVQSADQTPLKSSLDESQKSHIIVQRHAPSYPVEDNLDSPDEYSSDENDPDFIPDSNSSDEDIVPESSDEISLRSPSPVIPIPSRESSNHPVSSDETVSSTSEIEVMTTSNSEGKRHWDKPQYCPFCLQQQKKLPRHLTTPMHKDETQVKTWLATTDVKEKKKQLTLMRNYGNFLHNSTVLKKGKGTLIVVYRPGYDTDHNDYLPCQDCYGYYAKSDLWKHRCSQKPDVDCSGEPCVKKRRTMFCKPGRMLLPSTPGVSTRTNEILSSMNADNISRLVKSDELIKRFADKLVMKHGHSKDQAGYIRQRLREIARMVLEFRFLTGQTNVGLSTLICPTKFVAVTRATRVAAGFNDETHLYCTPSLALKIGHSMKTCAEILRGEALMSGDESTEKRCKGFLSLYSTQWEEKVSHHALRSLNEAQRNNPKLLPLTEDVVKLSQYLKDEVRVREQVLQSADGSREVQTAWSRLAEILLSQIILFNRKRPGEVSRMTIQDYSKCMNGEDTIIEGALTAWEKALCRVLWRVELIGKRSRTVVVLLTSDMKHALDLLLSKRAAAAINDGNDYLFSARYGEGHIRGTDTVREHANKCGAKQPANLRATRLRKHIATVSQIMNLKENELDVLANFLGHDIRTHRQYYRLPQSTIQVAKVSKVLLKMEKGDIRGLAGKTLQEVELNPNEDYNTDAESDAESGSDAESGSDAESDAEAEVNQVKPPAHGDRHGKGKQPTIKRAWSSKEKKAVARHLGGYLRGRTVPGKAAIIKLFQAETGTFSHRSWKNVKDFVRNQTRKQDPMSFLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIZ6</accession>
    <name>A0A914AIZ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063702.1">
        <property type="nucleotide sequence ID" value="XM_038207774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207774.1">
        <property type="protein sequence ID" value="XP_038063702.1"/>
        <property type="gene ID" value="LOC119734331"/>
    </dbReference>
    <dbReference type="GeneID" id="119734331"/>
    <dbReference type="OMA" id="GSIMMGS"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="230" mass="24337" checksum="C44867447281EEF4" modified="2023-02-22" version="1">MNPSIRGLGSVDGHLGLDGDGYVSQQSQRTKRMRTSFKHHQLRTMKTYFSLNHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKYRRSLLKKEQGDKSVGSPPGQADLIHGNSVSSPSTNGRSSPTSTTGGVPSLHGGCDTSSGSELGSIMMGSPVEDDGSCAGSYTSEGLSYSELKNASELSPAVADDVLTISAMPACSPNHTLAGDCLPSPNALNGSVLKTNLVDIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ90</accession>
    <name>A0A914AJ90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064055.1">
        <property type="nucleotide sequence ID" value="XM_038208127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208127.1">
        <property type="protein sequence ID" value="XP_038064055.1"/>
        <property type="gene ID" value="LOC119734592"/>
    </dbReference>
    <dbReference type="GeneID" id="119734592"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="98"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="39962" checksum="ECBF8DCCA7439DE0" modified="2023-02-22" version="1">MATTSDNGAFSMTTEMTEYMATKLSDWFIDNGPLNSTMDPDYQSMYHLPDINGSDYLLNTTFWFDLSTEEPTPIPLPGRASLIEIIIRVVSLIITLFGNALVLYTYATTKNLRTYTNYYIVGLAVADFFSGGVLQIIIFYHSFLGYWPFTEVACTCMTFISHVFLQATFLMTVVICYDRFRALNMPLKHLKDKTMRHACFLISLAYIIPVLLWTPIIVVFPYVGLATRIRPPLCTGPYALHPPLLIFTILVLSWIPMLVTSVLYAFVYSAVIRRGVNKKRGIGEEASSNNKTESRLASLRATRTLTYIMITMVVTALPWSIFALWAAIDPYTLPIRGHSFDVSGFNLGFVLTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALH5</accession>
    <name>A0A914ALH5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="7">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038064602.1">
        <property type="nucleotide sequence ID" value="XM_038208674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208674.1">
        <property type="protein sequence ID" value="XP_038064602.1"/>
        <property type="gene ID" value="LOC119735002"/>
    </dbReference>
    <dbReference type="GeneID" id="119735002"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="36088" checksum="9D37A05B9EE9745F" modified="2023-02-22" version="1">MGDDAIYATNDDAAMCKRFAVQQGYWKDPYIQFLVKAGERKAPEINRGYYARTEGLRSLMRQFLKLTHCACQIVNLGAGFDTNFWLLKDEGLLADVFVELDMRAVTSRKCHMIRTRSKLLEPVQASHGSEPVVIEDAELHSTHYHIMWADMRDLKQVEEKLGQVGLDKNKPTLFLSECVLVYMPLDKSNSLVKWAGTNFSSALFLNYEPVNMGDRFGHVMVENLRKRTCALAGVEACQSLETQKARFLSNGWEGAAAMDMMSVYRSLPADDLHRIERLEFMDEREPLQQLMDHYCIAWAWRDVNKIGLESIGFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM26</accession>
    <name>A0A914AM26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064484.1">
        <property type="nucleotide sequence ID" value="XM_038208556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AM26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208556.1">
        <property type="protein sequence ID" value="XP_038064484.1"/>
        <property type="gene ID" value="LOC119734920"/>
    </dbReference>
    <dbReference type="GeneID" id="119734920"/>
    <dbReference type="OMA" id="GEKPSYH"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="141"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="58956" checksum="CF4708AF0EB9A63C" modified="2023-02-22" version="1">MAALKPRSLSTKSKLMSSPSMVNQTADIRRGKSTTEPPTCPTRSQRQQRTATGRGGRRIASDVDVTDRVRQRRPNSLRQVADNHNEEELNANNEGQDVKFIDVPSESGAASGRPNSKCQTMSPQEILEMSQESKYEDVYDVNLHTCNIGTIPNLEKFTHLRLLDLSCNSIRQIANLHHNKELKELKLYGNEITSVSNLESLVELHTLQLQHNRIQTLGQCLSCLKKLKVLRLDSNRLRKLDSREIASCSQLTVLDISSNKIDTLHSLNCLSSLEELHATHNGLRAVTDLSRCKKLNEVNLSHNKLSDVSGLKGLPHITILQLSHNSLTTSCLKALGKLRSLQNLDVSYNQLTELSGIHEQFPSLEVLNVSDNRIHRWTSICSLAKCSSLSELYLSGNPFCAEQGEKPSYHHEIQELLPNLDILDGIHMKRNSAKSAPVMRPMSAASALSARQVENQLKHVEADLASFGASLAARFESVRSTMESLPLDPPSPRPGTALSIRSVSTSDGSRPGSRCNSRSRILEAQAFATKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMQ5</accession>
    <name>A0A914AMQ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064878.1">
        <property type="nucleotide sequence ID" value="XM_038208950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208950.1">
        <property type="protein sequence ID" value="XP_038064878.1"/>
        <property type="gene ID" value="LOC119735245"/>
    </dbReference>
    <dbReference type="GeneID" id="119735245"/>
    <dbReference type="OMA" id="CIEDGWK"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021978">
        <property type="entry name" value="PML-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12126">
        <property type="entry name" value="PML_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130680" checksum="3D6904AFF5453467" modified="2023-02-22" version="1">MATAASVGSAFEKIGIHLECSICTEKYKNPKETVLPQSGIQGLKTNFRLVGLIEEFELQEKVACSGDSKFLCETCDEDNEALHHCLDCGMNICTTCRKTHLRFPVSANHAVATLDDIRQGKDTIEAKKIAKSNIAKARKGVQGRAAEVIAEVKSEEKRLLDEITTSKEEQIRGLYPHKLWYLRFKKSQTAGVIDLGEVEHEGDKWQLHHEFGKRGSGEGEFKGARGIAAAAEPGEIAVTDGKNKRVVIYNNQGQAKNTILTVANDVVALSHQWVCAHPEKIMVYHRDTTHKCDFHTVPDDEVGKTDVLLVSVAVKPNGNIMVGDKKMKALIELNLRNGAILHTMPLKIRPDFLAVMSNGWIVVSDWEQGQVEIVDVSGGNPVTVATIKPTIGGKPVKSCRGVCSNSSGIYFAAITGKVNTGHIHHHGRAGQFISCVAQGLYDPYGITITADGQQMAVADLYSCPKIICSRGATVLHQGLHHRFVRAPTVHPPVGWFRDDDCASRQLWVSQAVPCQQSHPSSCYLVVQLREVTIELLVGYSLRPVDIEGHPEHPGVAAIKRLGHDSIGAHLECSICTDKYKQPKVLNCLHSFCEECLVKYRDGTHRGAPQIPCPVCCQETVLPQSGIQGLKTNFHLVGMIEEFELQEKVACSRDSKLLCETCDEENEALHHCLDCGMNICTTCRRTHLRFPVSANHAVETLNDIRQGKVNVTKKPDQSKCHKHKEGVTQFYCKTCDELICQVCTVLDHSKPDHDIIDIAKASKGFRQSLRKGFSAFEEDIKGLEVSLQGVASSKKLLNDNTVTARKRVQGRAADVIAKVKAEEKQLLDEITTQEKEQHKRLDEHKKTLSSLLHRKKHCLQTSQEVTKNASDSHFLSLHPVISTDMDKLRGQPTPTMAGLKLHPVFVKSKNLDIDLGKVMVEDTWEQLQCFGKQGSGEGEFESASGIAAAADPDEIAVADWKNKRVVICNSQGPTKKYLPINANDVVAVSNQWVCANPGKMMVYDRDTTHKFDFRTVPDDEVGKTAVRLASMAVMPNGNIIAGDKERKVLTVHNPRNGEILHTMPVKIKPDFLAVLSNGWIVISDSKQGLVEIVEVSNGNAVTVTRIQPTIDGKPVKNCQGVCSNSSGIYLAMDTGYVNTGHIHHYNCAGQFVSCVAQGLYNPCGITFTEDGQQLAVADLYSVKIYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMV2</accession>
    <name>A0A914AMV2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064928.1">
        <property type="nucleotide sequence ID" value="XM_038209000.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209000.1">
        <property type="protein sequence ID" value="XP_038064928.1"/>
        <property type="gene ID" value="LOC119735302"/>
    </dbReference>
    <dbReference type="GeneID" id="119735302"/>
    <dbReference type="OrthoDB" id="10039395at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1637"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="300"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="399"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="510"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="801"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="924"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1655" mass="185505" checksum="8FEA63E7C480CB35" modified="2023-02-22" version="1">MNKDRTWIGANDNCTTTLECIVRSDPRPAVTWYGPNGANINEDTDPDRLSLEEDLYYDSSFVYRLHSKLTINPVNSSTDYGMYRCRAANGIGTFVDHEIELKETGPPEAPKDLKISNDGALTEDTIVFNWEPGYDGGEELESYYMNIREIPGDFNASNWIQLGPRERYWAYTDLQPDTLYQIAGYARNILGPSPNTTLDVRTTPTSPSDLGITVSYTKSKGRIVVTGIPRADKDNRACLRLAGRDLENVFDVSLRPDLDCIQSDGDLEYFAAGPYFDNMRYYLCRDKLCGRHSYVAYVWELFVTKTPSGPVLEGDDVTLTCAFDIGLSGWIEWRHSLDREISTTLTEPMFTTDSNDLTFKGVFRNQSGWYRCAGNSIWSDDWNPNRLSDWTVNVVFYGPEISNKDRTWIGANDNYTATLECIIQGNPLPNVTWYGPNDTIITNDTIPDRISLEDTISGDGVLGYRVISQVVFAAVESSTDYGMYRCRAASSIGTFDEHEIQLKETGDPEPPKELQVEYVTDSFIWVIWESRYDGGEELENFFTNIRKIPDEFDPLDWISNRPDYNGLSYSDLQPDTLYQVAVYATNKHGSSPYATLTVRTNPGDPDEMGITVSYIQAQGKFVITGIPQDDDAGICVRLEVYDEAQGEWVSLRPDLDCIQHDGEFLYSSPYPTDHFHCLYCRDDVCGDWSHVTIVTPTPQPTRPTGDANSNQVVIIAVCVAGTIILLLVTIAMCYICKCCSGKPQDEVRRTAPQPNTTVEVYNPSYDPPPTYVQAVELEANAGKNNDDPPPAYDCVSSREAPQVTDENEEQVYVKLKSKDWSLSVTKIPRGDILEGSDVTFTCAIVSSNPDIFVWIEWQHLLSEGETTTVIEPTYVTGSHTLTLTGLSGNQAGSYRCVGSTSWSPAYWNPTTFSGWRGLSLIYRPVIMNKDRKWIGANNNYTTTLECIVRSDPRPAVTWYGPNGANINEDTDPDRVSLEEIDFYSPIGYSVHNKLTINPVNSSADYGMYRCRAANGIGTFVDHDIELKETGPPEAPKDLKISNDGALTEDTIVFNWEPGYDGGEELESYYMNIRKIPGDFNASNWIQLGPRERYWAYTDLQPDTLYQITGYARNILGPSPNTTLDVRTTPTSPSDLGITVSYTKSKGRIIVTGIPRADKDNRACLRLAGRDLENVFDVSLRPELDCIQSDGEFEYFADGPYFDNMRCYLCRDKLCGRHSYVAYVWELFVTKTPSGPVLKGDDVTLTCAFDIGLSGWIEWRHSLDREISTTITEPTYTTDNTDLTLKGVFRNQSGWYRCAGNSIWSDDRNPNKLSDWTVNVVFFGPDISNKDRTWIGANDNYTATLECIIQGNPLPNVTWYGPNDTIITNDTIPDRILLEDTISGDGAVGYRVISQVVFAAVDTSTDYGMYRCRAASSIGTFDEHEIQLKETGNPEPPKGLQVRVVTYSYIWVKWESGYDGGEKLENFFSNIRKIPDEFNPFAWISNGPDDLRAYYLFLQPDALYQVAVYATNKHGSSPYATLTVRTNPGDPDEMGITVSYIQAQCKFVITGIPQDDDAGICVRLEVYDEAQGEWVSLRPDLDCIQHDGEFLYSSPYPTDHFHCLYCRDDVCGYSSHVTIVTPTPQPTRPTGDANSNQVVIIAVCVAGTIILLVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQD5</accession>
    <name>A0A914AQD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038065649.1">
        <property type="nucleotide sequence ID" value="XM_038209721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209721.1">
        <property type="protein sequence ID" value="XP_038065649.1"/>
        <property type="gene ID" value="LOC119735789"/>
    </dbReference>
    <dbReference type="GeneID" id="119735789"/>
    <dbReference type="CTD" id="9354"/>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120812" checksum="C6B5595C24B29203" modified="2023-02-22" version="1">MEPDMVNPFALLQSATEETPEVMKGQSSEVVPAISAADESKEDKNPGSEVKDESAASEAQKVQAVDRMIQTVFLVTVDHENETSDRGMPPRCVYLVETADALKEENGGTWNWLGWDVIDRAIFERILLEDPAFHVINMSSASLSCTVEEQEAGEKEVMRYLLACYRRSVQQSKANKGDLHEYAECCRRVVISNAVTSLLTPELFNGQDLHAQTMTTLLQMFASGEIDHVFNFLLEVVDAVLLDEDLQLADAFVPLLDLLYKQMTENPSLSDARNAAFCAVLELFTRRTSLANILMDHVTPKDHKKAKSYEQTVLGIPLSLSCVPRHQQPTEFFTKPSRATQREHSATQEFLWQPMALLNDRMYEVFKGIFKSSTANKNRLLSWLGNCLHANAGRGKLWSREMQNFGQVYASDAFFMNLGAVMVRFCAPFTAPDSSKILSVDLSYSRLELSSTAGEEEMNDKGVHLRGLPKETCLIKLADDTEGGRNPTASPALPTNPPYKFTTEVFFLAQRCLNLGYHSVLERFNRLNRELHRIQEVYQEMQRLGAAGGSNPAVERLREQMDIAMALFLSLKTALLEPQLIQHSWNLHLATARLLIQLATTDDRTTLRTPSYPLPPGEDGGSAPPCLAYVPEFLAENLTNFLQFLRRFAEQKFEDGAESLGHLMTFIVTFMGSKGRMNNPHLRAKLAEVLEGLIPPKEQSKSIVTSFHREKVFQEHPLLPLVSRSLLSIYVDIEFSGDDHAFEQKFNYRRPMYHILKYLWSLEKHRQSMKEIAAEALLSMEAATAPLFLRFINLLINDAIFMLDEAMDNLKQIKEMQHQRDSGEWRSLRPQDLQQRESTLRTNGSIARFFNVMSNESMNILNFITSEIKTIFVHPVMVDRVAAMFNDFLLKLVGPKMGALKVKNFDEFEFKPGSLVKHICQVYLNLGDNAEFCAAVSRDGRSYSSSLFVRADRVLKKIIAPIEMIEEMTAFEDRVRAMAAKQEEEEETFADAPDEFIDPLTFTLMSDPVTLPSSRTVMDRAVIARHLLSDHTDPFNRSPLTMDEVVTNDELRKKIEAWKQENSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR34</accession>
    <name>A0A914AR34_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066118.1">
        <property type="nucleotide sequence ID" value="XM_038210190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210190.1">
        <property type="protein sequence ID" value="XP_038066118.1"/>
        <property type="gene ID" value="LOC119736167"/>
    </dbReference>
    <dbReference type="GeneID" id="119736167"/>
    <dbReference type="OMA" id="CTSEAHS"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="305" mass="33869" checksum="26FA9283350629C2" modified="2023-02-22" version="1">MATGASAFSVWGKVGEEHMQCPVCQDYFKQPKILNCQHSVCEACLEKEKVSAVSKVECPVCWQATTLPQDGGVSALRTNFKLVDMVEAAHKLHQRERGSVPVCRAHSWKESRLYCNTCRELICEVCTSEAHSGHEHQAVGAAASEARQAAEGSIAIIKALTKDLEDKLKVIQEVERDLKTAAEDSRQELDQRANEEVARVRAAKQRIKDEINSTEKARARTLADCKREYTVMGENMKSAVDGYRAAVESGNYAGDYEFVSLQPKIAELAELGGRKGPKVEPALSVLRFERFESEDNIRLGRLVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS34</accession>
    <name>A0A914AS34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066463.1">
        <property type="nucleotide sequence ID" value="XM_038210535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210535.1">
        <property type="protein sequence ID" value="XP_038066463.1"/>
        <property type="gene ID" value="LOC119736522"/>
    </dbReference>
    <dbReference type="GeneID" id="119736522"/>
    <dbReference type="OMA" id="RFASNIM"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="92"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="416" mass="46525" checksum="F9FD8CACD3A1FE08" modified="2023-02-22" version="1">MDGSRAQDCIHGSHYEACDVSFYIKDSNTHSDIQCTENNRPYYSAYNYTYTSTIMNATTVLPVTASPPLYSYQARIGLGCVWVTISILGLIGNSLVIWSVVLSKKLRTVTNAFVVNLSLVDFWTSLSYPWQAVAILSHGSWPLATEVPCYIAAVQFYTGLGGSLYSLAAIAFNRFMLVTQKTETYSRWYSPGKVSVMIAATWVIPSIVFFLPPILGIGDFGYDPQDNTCSDKDGHPRGPEYNLAQSLGLYPIPMLIIVSSYTALYIHLKRHFRKQKRRRAQQGSPAQDVDGGTVGESTVSFTVVSESSPVPANDMTQGIRREISRQQLAITKNLFMVFFIFFLLMSPYFISLAIPSSGTFALYGATISMLNSCVNPIIYTAKHPQFKLVLRNILRCRYSQIPEPSDWLKSILSRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS60</accession>
    <name>A0A914AS60_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066294.1">
        <property type="nucleotide sequence ID" value="XM_038210366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210366.1">
        <property type="protein sequence ID" value="XP_038066294.1"/>
        <property type="gene ID" value="LOC119736351"/>
    </dbReference>
    <dbReference type="GeneID" id="119736351"/>
    <dbReference type="OMA" id="RDIRYYC"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115728" checksum="4A8AEB12B8086091" modified="2023-02-22" version="1">MMADVNSSDLVSLQDGIKIIKVPDLVNETNHVVFAQYTSEPLSPEKPYFRVKVVQLAKEAVIAIGISKETDLDAEDVEDDEVDKSSKRKSDAVVYFSDDGSISSPANSSKEFVQTFGQGDVVGLYIDYHSKHKSLVCVSKNDQLVHRRWLALKEEFLLPTINVWWGTAELHVDWLSSSPPISSLDNLSDWNMPDTVTANDNLLSLRTSSKVAAIQAPYPLHKSSTQYVEMTIVSMGEEAAIGPVIGLTSALLDDNRLPGTMMEAVGYSGVDGTIYFETPENATQLGENCKCSAGDTMGCGLVFVDTVVANPRLPANVIVYFTKNGQVVNQRSLDQPMGGFYPTIGLACQGCTVKVNTECPTPSALDIDAWRAEAIKKTMTFGGFGPLGPQQSHGPKHIEGQKSGHYRFNELLGVPTNDVIRLKENTHKKQLIQLLKTMTPEQPYFTVTITEDDPDGRVVMGISRDGQSVGDMPGGLVDSVGYSCEGQICNGVDYFKTDKYTKGDVVGCYVEYFSESVKIVQFVKNGQLVGLTSLTGGSRDLYPSLGFVGEPCAVKVTWPESRPSPPATFSKDKLSSWMKCTGLCIRDSRLSVLKKMRRLRAMCLRSPQPLTRAWSYFEVVVHSKLLSTPTQKVSKAPVIGLTNDMGIKPFKKLTHDEATRDIRYYCNSNSIGFKDALSHNMLSQKQYLESGDRLGFGIVYPSVKNQPNDRAQQVVVVYCAINGIVIHHQAMQQPAGGFYPIISLYKYGSEVDIINSCSPPSMGDISNWLADAEHLGKAITQAKKDAAGDHKQTAEDRQARPASPAERTQNHLNKYKIYIYCDPVRYNEATHIQAKLETKGFATVLPQKDALNNSTLTSDLTASVKTCDSLVCCLGPEIGTSQRAVTVLDVCKASGRPILPCILAHVAWPPEGLTQEHFQMLTLDKIEMTQDFDWGVEQVAEKTLNLKGKGYNGKLIKVELGDAAKMLYTDAQKGDKTANKESDPDALKTAVADADRRKATSFGNTSPNGSPPQDKPLSRPQSVTPAGKANRASSGKPRAQSAGVGGQGSGSVQKSKMCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUA9</accession>
    <name>A0A914AUA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067342.1">
        <property type="nucleotide sequence ID" value="XM_038211414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211414.1">
        <property type="protein sequence ID" value="XP_038067342.1"/>
        <property type="gene ID" value="LOC119737224"/>
    </dbReference>
    <dbReference type="GeneID" id="119737224"/>
    <dbReference type="OMA" id="NEKCLNR"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="42240" checksum="1D3AF4A15AFFF9AD" modified="2023-02-22" version="1">MASSSLQENQTFRDRVHENKEVAKTTGDIYKKKYATLKRKCESIQLDNEKCLNRLYYVKKAVRKMSRERRFLMTKLNKYGDDFKNATLPLPIEDDSMLHLMSVSNPIAPKFPASRGLAGLVSKSKRKASTGRRPGRPRLISEMTSRDDMPRSSGRGGKRKRMASQSKQEKEKDPLAPKKPANAFLMFCQTKRQEESSSKDQDGAGSDVSHQELTRQLAKEWNYLGAGEKETYYTMYERDKDRYHKEMKEYIKSNNLEPLPTTNPMPQPPTVTVTVTRTEPVSNVQFVSSELPVVVKSEPNPDIQLPPSSASALSAVTTPVITTVSKPETLMPIKQEAKVETLMSLECRTPKLKSCLQPKSPVEGDDPYHFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUF0</accession>
    <name>A0A914AUF0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Survivin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067136.1">
        <property type="nucleotide sequence ID" value="XM_038211208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067137.1">
        <property type="nucleotide sequence ID" value="XM_038211209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067138.1">
        <property type="nucleotide sequence ID" value="XM_038211210.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067139.1">
        <property type="nucleotide sequence ID" value="XM_038211211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211208.1">
        <property type="protein sequence ID" value="XP_038067136.1"/>
        <property type="gene ID" value="LOC119737112"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211209.1">
        <property type="protein sequence ID" value="XP_038067137.1"/>
        <property type="gene ID" value="LOC119737112"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211210.1">
        <property type="protein sequence ID" value="XP_038067138.1"/>
        <property type="gene ID" value="LOC119737112"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211211.1">
        <property type="protein sequence ID" value="XP_038067139.1"/>
        <property type="gene ID" value="LOC119737112"/>
    </dbReference>
    <dbReference type="GeneID" id="119737112"/>
    <dbReference type="CTD" id="332"/>
    <dbReference type="OMA" id="EDCACTS"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000009">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17473" checksum="53DE869638F3DADD" modified="2023-02-22" version="1">MGKSDVSDASDEAKQRQNFLMNTEANRLASFQDWPFDEDCNCVPSKMAAAGFYHCPTQQEPDLVRCFMCSKELDGWEPTDDPLEEHKSHAPKCAFITKKKDEKDMTMAEFFKLESVRQHNRVMTHVENRIKEFTYEAEKTRQQIEGLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUF5</accession>
    <name>A0A914AUF5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 2U1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067144.1">
        <property type="nucleotide sequence ID" value="XM_038211216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211216.1">
        <property type="protein sequence ID" value="XP_038067144.1"/>
        <property type="gene ID" value="LOC119737118"/>
    </dbReference>
    <dbReference type="GeneID" id="119737118"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56168" checksum="75829C46B5F0C168" modified="2023-02-22" version="1">MDSFSGFGPLDARSILLGLVVFLVLYRFLRRAPLNLPPGPTGWPVLGYLPQLATARDDPHVVFSKLAARYGDIISVNLAGTLVVVLHGYHTIKEAFNLHQLSARPTLYVSERLRPGVGIIASSGEIWTEIRRFSLTVLRGFGVGKSSFEENIATEAKFLIEEWQKEDGSPFDPKHLISSAVSNVICSVVFGERFQYTDDNLQRLLQYSDDILDQVGAGGAIEFSSFLSKLTFLPSIRRYVATARRFNEQIDLMVRAHAVDYDADSLRDLIDTFLKQKEVKESTAGGESKVFTGNNLKKVVGDLFMAGSETTTTTLRWSLLYMMTYPEVQSRVQKELDDVTRRNRFPRMSDRPDLPYTEAVICELQRISTIVPLAVPHCSTEDITFQGYTIPKGAIVLSNLWHDHFDPAVWEEPEAFRPERFRDKDGKLISREELTVFGIGRRICLGEHLARMELFIFFTLLLHEFTFKNPPDAPPVSLQAINGGTWAPLSFKVCAVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWT0</accession>
    <name>A0A914AWT0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067974.1">
        <property type="nucleotide sequence ID" value="XM_038212046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWT0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212046.1">
        <property type="protein sequence ID" value="XP_038067974.1"/>
        <property type="gene ID" value="LOC119737590"/>
    </dbReference>
    <dbReference type="GeneID" id="119737590"/>
    <dbReference type="CTD" id="51647"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000005">
        <property type="entry name" value="Mitotic spindle-associated mmxd complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="157" mass="17705" checksum="AAC40AA5C8E45FD0" modified="2023-02-22" version="1">MEDGERLDNVNPTIHKRLPDREITADDDNDDVADKIDAREIFDLIRHINDPEHPYSLEDLNVVSHSQVEVNDEENRVKIMFTPTIPHCSMATLIGLSIRVKLIRSLPPRFKVDVKITPGSHASEEAVNKQLADKERVAAALENNHLLEVVNQCLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXR2</accession>
    <name>A0A914AXR2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068056.1">
        <property type="nucleotide sequence ID" value="XM_038212128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212128.1">
        <property type="protein sequence ID" value="XP_038068056.1"/>
        <property type="gene ID" value="LOC119737643"/>
    </dbReference>
    <dbReference type="GeneID" id="119737643"/>
    <dbReference type="OMA" id="DMEMAEM"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003851">
        <property type="term" value="F:N-acylsphingosine galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF54">
        <property type="entry name" value="2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036927190" evidence="5">
        <location>
            <begin position="21"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="604" mass="67600" checksum="8789478DA1BD342C" modified="2023-02-22" version="1">MGKQKVVFLLVAMWLLAANGQSTGGDSTEASGNNGPTSRVQGKLDRVIAARFESEVSGLRDRASFASDAPGLAGGGPSLSAANGTSKRILIVDCMMDGSHTHIQRITARELASRGHNVTWLTTKELLYWPTEEDKKLINFRLFNSPMAYFENKQKILDYWTRKSLSGEMSTFSWYAKMWLGRPDDEVKRIFEAVEGLMRIVFQETDYDELRAANFDLVLCEVMFPACSSVAHDILKVPFINTVNGGFLGTRYSRWAKQPSPLAYVPEFVTGYTDIMSFPQRVKNYLISAATLLIYDYVLFAGVDRARAEAGLDTRMGTREIVARSELFILNWDFHIEFPRPISPNTILIGGLTIGPPKPLPQVFEDFIQGSGEHGVVIFSVSTLLHVMDMDMAEMIAAALAKLPQRVIWKYLGEERPGALGNNTMIVPWISQKDLMAHEKTRLLIYHGGLNGGYEAMYYGVPILGIPLFTDQVDDLVRLKYHVGMADYFPKGVRGLTSEQLYQGIRRVLDDPSYQENATRASGKLRDSQSERGVTEGLPLARTARWIEYAMEHGTAHLQTKQDSLAWYQHILLDVTCIYVAAIGAVLWALNKLCCCCCRRQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXS4</accession>
    <name>A0A914AXS4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068945.1">
        <property type="nucleotide sequence ID" value="XM_038213017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXS4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213017.1">
        <property type="protein sequence ID" value="XP_038068945.1"/>
        <property type="gene ID" value="LOC119738230"/>
    </dbReference>
    <dbReference type="GeneID" id="119738230"/>
    <dbReference type="CTD" id="64432"/>
    <dbReference type="OMA" id="FCICEVP"/>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000103">
        <property type="entry name" value="28S ribosomal protein S25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="20660" checksum="11D0F4B1668B8000" modified="2023-02-22" version="1">MPMKGRFPLRRTLRYLEQGHVHLKDTVKIVTINYKTHGDFSEGTRDFVFYNLPQLQYKNPTVQMKTFQNITPSPYIRCFLDDGNDVLIDTDSKSNLEILEHLNKVLGKSEEVLERERKAQERQSNPAHFGSGHRRRCICEIPGQVPCPGKVSLPKELRGKYRDLKADSLKPPRGVRPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXV2</accession>
    <name>A0A914AXV2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">GPI inositol-deacylase</fullName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum. Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038068975.1">
        <property type="nucleotide sequence ID" value="XM_038213047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213047.1">
        <property type="protein sequence ID" value="XP_038068975.1"/>
        <property type="gene ID" value="LOC119738246"/>
    </dbReference>
    <dbReference type="GeneID" id="119738246"/>
    <dbReference type="CTD" id="80055"/>
    <dbReference type="OMA" id="YGLYYYY"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000026">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24660">
        <property type="entry name" value="PGAP1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036972408" description="GPI inositol-deacylase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="900"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="16">
        <location>
            <begin position="78"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="17">
        <location>
            <begin position="668"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="788"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="944" mass="105816" checksum="E0B057B09A0A7E81" modified="2023-02-22" version="1">MATKNKIICSILLALLGLGFYDIFRNFEENGCAMTYMFQWPSYIDIKMNDGIQQRYPQYSLSLYGEGDYLKQSRNLKLNGIPVLFIPGNAGSYKQVRSLGSAALRKAQAYSFHFNYFTIDFNEELTGVYGGTLKQQTEYVHECIRHILTLYKHKKNPPTSVVLVGHSMGGVIARALFTLPDFQQSLVHTVITQATPHVSPVIGADKYLVDFYSTVNKYWKEHIHGDGLKDVTLLSVSGGHRDTMVRSGLTSLHDIVPPNRGLSVNAMSVPRVWLSTDHQCVVWCKELVLASKRALFQMVDSQTKQISTDPDFRMKVLRHHFVEHNGKEKFSFAEAKPKTFEGATFELATNSQKHSVGRRAKKTTHYLFPVEQSNTQDAFVALAGIEPRDWLFVCQEGNSTSCSRGVDISATARLIPPLKADMKEVVVKLDDYPDAKHVVLKVPSGKAVPVTAELYDTNQRHVNFTLPGPFSGPSASIVLEFTDVGATFYNITMLDFNLFHLAYEARLEPLTCDTDLHSDANTTLRLHIPWAEGQDMFSVAKAGQINKLSLKLPSGWPSHYNQSAQLYTYLNPRCRYTIRGVWSIQEKMGQVVRFHANLLPNFLVVVLVFLISFQLKHIYTEKAIDDFIWMQSTYCKPNAIALVISIFRGVVKYESLDKTFDLRSFEDKNIFFPVLPLVFFLFGYALLTQLALLTSFKVALYARLAVFVKGTKADEHQFNPAGPTPWLMYGVVGGLVALSAMTCGTLGLIAALVLYFFKVVGMKAKVIRLSHCLNIHGAIADANVNATPSPKDEVASSVKENDSSSTSTEDVKPPKPDDPKPRDLSPLGLAKETYHFHFAIMLLLWCLCVLNAPALIVWFKNLGYSLHLAKDPSVYIAAVVCSTMAVFLDGRYTIPTCKGLCKLSSWLFLVFLWLMVLYTLESAYLVSYFICAVFVILSALQIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYJ9</accession>
    <name>A0A914AYJ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068777.1">
        <property type="nucleotide sequence ID" value="XM_038212849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212849.1">
        <property type="protein sequence ID" value="XP_038068777.1"/>
        <property type="gene ID" value="LOC119738109"/>
    </dbReference>
    <dbReference type="GeneID" id="119738109"/>
    <dbReference type="OMA" id="MAFRTHQ"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="496"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="586" mass="66035" checksum="ACB56E2488CE4842" modified="2023-02-22" version="1">MATFGNIGEFCEKKETWEMYTDRLGEYFAANNISDAARKRAILNSVVGSQTYKLISDLLAPKKPNEATYQELVDRLEKHFKPTKSSIIARFQFNSRCRRSGESIAEYLAALRALASDCKFGQNLDEMLRDRLVCGVQNERIQKSLLAQPEDKLDLKRTVELAQSMQLAGDQAKMLSASTSTMAESNTTVNAFRKKQAQRPNRPTWSNQRQTSARSSSTQQQKPRKPCGNCGTFHKRRECPAYGKTCHKCNKKNHYADYCRSSRHVYTVNPDSYSEEDEPAVDEQELFYVRAVDNTNLHLKHDIHATLVVNNTHVPVQLDTGARCNVLPMHVYNVIAPPKSIDNSKSTKLIAYGGTELHTVGLATLPCRIDSSQTDHNIDFHIVDTQVKAILGLTDCLRLGLLSVNNLVYHVSNDTTSPQVFKDYEDLFDSSLGSLPVIYTMTIDPNATPVVRPPRRIPAAMQDKVKSELQRMTTLGVITPVSEPTDWVSSMVATHKKNSEEIRLCIDPRDLNEALKRPHHPTRTVEEVAAKMDGATVFSVLDAKCSFWQIPLDYESSLLTTFSTPYGRYRYLRMPYGLCSASDVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYR9</accession>
    <name>A0A914AYR9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038068847.1">
        <property type="nucleotide sequence ID" value="XM_038212919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212919.1">
        <property type="protein sequence ID" value="XP_038068847.1"/>
        <property type="gene ID" value="LOC119738168"/>
    </dbReference>
    <dbReference type="GeneID" id="119738168"/>
    <dbReference type="CTD" id="83475"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="353" mass="39147" checksum="05CDF860A95336EB" modified="2023-02-22" version="1">MCVTLAALTHNFSLSNFCDIFSIFCSPPHITKQPASQFITMPEDTSKIERIGAILVDPTRPLPERFRALFTLRNLGGSTALACIGRCFADDSALLKHECAYCLGQMQDEGAISMLVEVLEDVKQEPIVRHEAGEALGAIGSPDILNILKKYEHDPITEIAETCQLAIQRIEWLQSEQRTQEESQISANPFKSVDPAPPAVPATLEELQARLLDEDASLFDRYRAMFALRNRNDEPAVRALAQGLQCKSALFRHEIAYVLGQMQHGACIPQLLETLAKSEENSMVRHECAEALGSIAQEGCLDKLRDYIGDGERVVRESCVIALDMGEHETSGEFHYCDGLVKLESESKHQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZU7</accession>
    <name>A0A914AZU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069675.1">
        <property type="nucleotide sequence ID" value="XM_038213747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213747.1">
        <property type="protein sequence ID" value="XP_038069675.1"/>
        <property type="gene ID" value="LOC119738787"/>
    </dbReference>
    <dbReference type="GeneID" id="119738787"/>
    <dbReference type="OMA" id="WEGCKWR"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002639">
        <property type="entry name" value="Kruppel-Like Factor (Zinc finger protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="390" mass="43309" checksum="A658D71B5618A04F" modified="2023-02-22" version="1">MVDVYRTRSSLERESWTLQRLNSAGDLEEESDANSSSSDEISCMSDSNSSLSPSEDDLFLEYLFSQGLADTEMSNTIRDALFSVRIDHNKLDFDAVADSVYPDGEPVYYTPQPTPIYPPDPLLHHSYNLVEPPKIACDDYFKPLPYIMSTDSMNGNYLHPPWQQCQGGVNLPTLDSPRQPGKPPIPRGVMASHSPPAVPLSRSVTKGLSVSETVIQVSTPVKNEPVSPQNLTSQRMALLPASGVRITHIPVTTPTGAVGNTSPAEPTTAVRKPSRSRGTGKVADELKIHKCTYPNCGKMYSKSSHLKAHLRRHTGEKPFVCTWEGCKWRFSRSDELARHKRSHSGVKPYQCTICEKRFSRSDHLSKHIKVHMNGVTRGVKTTNSNMMVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0W3</accession>
    <name>A0A914B0W3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069419.1">
        <property type="nucleotide sequence ID" value="XM_038213491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0W3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213491.1">
        <property type="protein sequence ID" value="XP_038069419.1"/>
        <property type="gene ID" value="LOC119738584"/>
    </dbReference>
    <dbReference type="GeneID" id="119738584"/>
    <dbReference type="OMA" id="SYFGVNC"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037955097" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="561"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="665"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="760"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="860"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="964"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1169" mass="125501" checksum="44E523D4EB462D97" modified="2023-02-22" version="1">MRFLTHMFLAIIAILLVCESSVAVYLAGRPSAQTSNYKEYTPAYKGVDDTPGSCAITKASVHPWWRVNMMEEYCVGTITVVNRADCCAERLIGATVRAGLSPSVTENTVCGSPVTAEQATPGAWLRFTCDPPVRARYLSVDIDLRGSGRLQFLAVCEVKVEESQAMECPGWAANATGFLDATCLTPTPLLDPNGDGGAFIGTYLGARDATASVSFGRMSNTGHNGAPSLPASAHQVPHPMGSTDADLLYLPATGGLVRIGAFFCLATKDETRTQITMIILNKNDVHVRPVVLTKTVSLMESVTLEMEAVNPPNSDWRWRHDGGPFIGRSQDRLTHFIPSVCPRDAGIYECHVNTFRPLQRHAIMQLIVRACPSGRWGPDVSCTNICPPCYNGGVCDALSGRCVCAPGFKGRYCEEVLGLNFFGQDGSHYCQGSDDGNGCQGKLFCLPDPYGCSCAAGFKGFDCMHECDEGTYGADCKQTCHCALNVTCEKDTGKCLGACAPSYFGVNCQQTDCANGFFGAKCDQTCHCQGVTCHRDTGECEGPCAAPYFGINCQETGFGGVPNLVSYPSESTPGHVILSWGKDSASVYTIGYELVNRGHCEPITSPDRKFLPDRFDKETSHAILTDLEPSSVYRVYVQSHYGIHSIVPTESFVEVSTSPANDSRSVKDFRALDITSNGFLLNWSPVQCADAYYLTSDLLQMGHCSRSDTQQERSTFLTQSTSVTINCREPFATYSVSIVASVEGVNGSASTLEVATTKAAPGTPDGLTVVSSATNSLHFAWDDLPCEEHHGQFEGYRYALRDVSTGDTVASGIESVSEVGFTDLTPCRQYEFRVAALASDLQGSYSNWLSAQTAVQGPGSVNNLIVRDTSSSATTVSWQPPLLNTCGISEYRLRYVLTIQDMCSMTALTASPLVPVSTTSTSTRLTGLVPASQYQAFIKAINAADEGQEASVLWTTNESVPTNPPEDVMILAISANRSTGFSWSQPSCGGRGGVITKYAYRLSHQDGELVIIDSADETSREWVVFAGLEQFREYGFRVAATTSAGVGPYSQIIRATVNPGKDANLYSTTAPGISSAERKATAKSPRKSTDGDPVRPLPPAKSLGSAADISGTVVAVVVMGLLLIAVVVVAYVKLKRGGGSFTMFRRRVGWSGFANDEAEMMTEMDSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1Q2</accession>
    <name>A0A914B1Q2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069426.1">
        <property type="nucleotide sequence ID" value="XM_038213498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1Q2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213498.1">
        <property type="protein sequence ID" value="XP_038069426.1"/>
        <property type="gene ID" value="LOC119738591"/>
    </dbReference>
    <dbReference type="GeneID" id="119738591"/>
    <dbReference type="OrthoDB" id="6619140at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50695" checksum="7A30CA529B82EA84" modified="2023-02-22" version="1">MGKDGVDKQARKEDPIKCRRCGETFLHQRSLIRHLAVEHGPKIYFRCRRCAHKNNRSDNLRYHYRDCHPDKVAEVADIKGETCEEIEKLERRCETGGNRRKRSPTQPKSSKEKQPKKDKPPKKETDACRKASEKPQGKKRGSSPGSSGKEDRCRSADARSQSGGEPSKKRGREEATEKRSTKKKPARPAACTVSRAPDSGSEEQVIEAPAQVEEPLQEADIPVTTQGVDQREREAHDKEVDDAAPEVQGPLPLAAEDLREMAEIELSPTPMSVCEPDDDFVDEVPRPTRGGKSIRLMQMKIGSNHGDGREEVDQQSASGARPLLRLSSILPGQAVKVREVRETYLYREESKVLRGETHREFDVVYLRPVPTEPAPPAPESRIRRIVQSTETGEERLGPSYNEEGLEQAMAGKVTRVTETSSRVVYQDDQKIMKDKTTRVYEVAFTAGVAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B283</accession>
    <name>A0A914B283_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tumor protein p53-inducible nuclear protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070023.1">
        <property type="nucleotide sequence ID" value="XM_038214095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B283"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214095.1">
        <property type="protein sequence ID" value="XP_038070023.1"/>
        <property type="gene ID" value="LOC119739239"/>
    </dbReference>
    <dbReference type="GeneID" id="119739239"/>
    <dbReference type="OMA" id="RHNKAYH"/>
    <dbReference type="OrthoDB" id="10041339at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF3">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25609" checksum="0692C4F3C412B8F8" modified="2023-02-22" version="1">MLSGLAEYIFGSAATGEAEPTSAEGAGTRPSASMQLTYAEDDWVLVDVTNSPKRAKESHPSHGTPPLGIPIPPQLEESWLVTPPPCFTAGGRSPQELATSPMENLLIEHPSMSVYGPRNGGNHTTVMRARRTNQHEANASQVAKRPKPRNLRVRNAEPPRRAAAVAARLGLENPPNLAAIQEAETMQREKRGSLSRSKVERHNKAYHQQSRSGKRHYRQNVSGRHSRVTYKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2W8</accession>
    <name>A0A914B2W8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038070149.1">
        <property type="nucleotide sequence ID" value="XM_038214221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214221.1">
        <property type="protein sequence ID" value="XP_038070149.1"/>
        <property type="gene ID" value="LOC119739331"/>
    </dbReference>
    <dbReference type="GeneID" id="119739331"/>
    <dbReference type="CTD" id="5184"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="482" mass="53500" checksum="C6C1C91735DEE9D6" modified="2023-02-22" version="1">MPPAPGYSQGGKTHTVPATLHADNRGRLLERLRANKDVPAGSVVLLEGGKDINQYCTDIELVFRQESYFMWTFGVELAGFYGAVAVDTGKAVLFAPKIPESYIVYMGELPSNDNIKERYAVDEVHYVEEITTVLEAMNPATLLTLKGVNSDSGLTSHEAEFDGIKKFKVNNSILHPEISECRVFKSPGELEVLRYVCALSCEAHKDVMRKARPGLMEYQLESTFQHYVYYHGGCRRVAYTCICASGHNSSVLHYGHAGAPNNSQIQDGDICTFDMGAEYYGYASDITVAFPANGKFNNDQRIIYETVLKANRAVFKAMKPGVLWTDMHLLAERTILVELKSHGLVKGDVDEMMKVYLGAVFMPHGLGHFMGCDTHDVGGYPEGVERVQRPGIRNLRTSRVLEAGMVITVEPGCYFIKATLEPALKDPKMMPFLCPDVLERFKNFGGVRIEDDVLVTKDGAENLSPYVPREIAEIEALMAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B397</accession>
    <name>A0A914B397_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070388.1">
        <property type="nucleotide sequence ID" value="XM_038214460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070389.1">
        <property type="nucleotide sequence ID" value="XM_038214461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070390.1">
        <property type="nucleotide sequence ID" value="XM_038214462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B397"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214460.1">
        <property type="protein sequence ID" value="XP_038070388.1"/>
        <property type="gene ID" value="LOC119739486"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214461.1">
        <property type="protein sequence ID" value="XP_038070389.1"/>
        <property type="gene ID" value="LOC119739486"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214462.1">
        <property type="protein sequence ID" value="XP_038070390.1"/>
        <property type="gene ID" value="LOC119739486"/>
    </dbReference>
    <dbReference type="GeneID" id="119739486"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="26689" checksum="BB0F628369BCFDE8" modified="2023-02-22" version="1">MNMFGGHNPSGFGYGQHGGFGSPPGANPQFAGSPHGAGAGAAVGHANQYAGLSPGISNVTNRNDMKSRASRIFIGNLNTGQVTTQEIVSRFSKYGRITGVSIHEGYGFVQYNNELNARQAIEGEYGAILSRQPIDVRIASEPNPNRPKGFKRVQGNVTSGYLDPATLPVIVPAGPPAAKKQKTFTGKKAQQFAGQGPDQWICAYCKDEADDEWELMKHVAFSHKTQIYIDNPEELKTVQEGTVGFNGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4J7</accession>
    <name>A0A914B4J7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070857.1">
        <property type="nucleotide sequence ID" value="XM_038214929.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070858.1">
        <property type="nucleotide sequence ID" value="XM_038214930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4J7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214929.1">
        <property type="protein sequence ID" value="XP_038070857.1"/>
        <property type="gene ID" value="LOC119739837"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214930.1">
        <property type="protein sequence ID" value="XP_038070858.1"/>
        <property type="gene ID" value="LOC119739837"/>
    </dbReference>
    <dbReference type="GeneID" id="119739837"/>
    <dbReference type="OMA" id="AKMAHER"/>
    <dbReference type="OrthoDB" id="10030037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="383"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="921" mass="105952" checksum="2A3455E66C49BC12" modified="2023-02-22" version="1">METCTPDVRHNAYFTKSNPGVQHYKSASDGDSPDASMPMGNLASPLVDSGYREGSVTYNHEESTNSYGSLTGEGPVGTGPPTITPVSGQLEKFKQHRMIRPVPLKAASPSRSLDSPCSTSSRHSLPSSPASMPDQTSDKPQQQQLQQNQQQQRQRHQPPDVVLTNQQKHGFAGNHFGGLPTKCLSLQDITPKQRNYHDNGPRGPSYGDSKAWGKQPTQPRRIQPAHSLNYLNRTVQNLQNHKLLPDYKRRNISQSSSQVDNRRNGNNNGSRSNPKKPVRITHSNPSYGHVMDYNSNRLDGKSSASSSSQVSSVQEETEMDEIAALRQKVLEKEAQLTTLRDTMDNNEAAILKVHEDKHREWNEETSWLRKELQEQEDTSRKIRHSLQAQIYKLEQEKKTLREKIDVSHHPPSKEVEDLKWQLRNLKEQLSIKTQEIANLRNKLTYQEQRLSQRAKTVASQEAELERLRQEMQRTGEATPEAHRRLLQEKEAELSETRIETNHLRELKENLAQEVKVQEEELTLLRTKIGTKDQELSQERCEVAYLREVQEKLNQQLQKKAKSGGLLSGKGNQSSNVNNLKERLAQREKEVTQLKEQLRRVQEDKDQELGKLRQNMKERNGDIEKLQKKLSEAEKDRSMLRNKLANGKGAGGTKMTPLQRQLESDFMDMQVKLTTREREAFQLKRELALLQEKNVSDISSLKSQLEEHEQEQQAVQDRMLQRETEIGFLMDKMKSQENKIAMLKEELEKPEPPKKARDSQDHQQRVEELEREVVALRNERTELHTQVVDLGEESAMYKEKLDKISKGVRTLSTSQSNLVNLAKGMSQGVANPGPPRVDEEENLRQEIRSLREKLAESRKRLQGQEGAMSRERRVWQEEKEKVIKYQKQLQLNYVQMCRRNRSLESDLQQLTVELEHKEISHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B553</accession>
    <name>A0A914B553_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071208.1">
        <property type="nucleotide sequence ID" value="XM_038215280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B553"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215280.1">
        <property type="protein sequence ID" value="XP_038071208.1"/>
        <property type="gene ID" value="LOC119740077"/>
    </dbReference>
    <dbReference type="GeneID" id="119740077"/>
    <dbReference type="OMA" id="ACNQENQ"/>
    <dbReference type="OrthoDB" id="10453040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="24200" checksum="CF5C2EDF825632B9" modified="2023-02-22" version="1">MRIASLGSSESKADQSDQVPRKRTRKRRHLRSSPPYRSSASTSSSSSSSSSNGSRQTVQDDVLVPLLDCTELHRVASSCPMRGAGCDTETAFTFSSLSSSSSSTTTRSSASSAVTGLNYCGSPTGVLSQQNSPVDRTHSPGYDFRETTARRRSYLESTESSVQPMQYHPLACNQENQPHERSGRKVGLREFFFFFYPALCGRGQNFHHMVKGNLVGGPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B585</accession>
    <name>A0A914B585_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 87</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071406.1">
        <property type="nucleotide sequence ID" value="XM_038215478.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071407.1">
        <property type="nucleotide sequence ID" value="XM_038215479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B585"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215478.1">
        <property type="protein sequence ID" value="XP_038071406.1"/>
        <property type="gene ID" value="LOC119740237"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215479.1">
        <property type="protein sequence ID" value="XP_038071407.1"/>
        <property type="gene ID" value="LOC119740237"/>
    </dbReference>
    <dbReference type="GeneID" id="119740237"/>
    <dbReference type="CTD" id="55231"/>
    <dbReference type="OMA" id="GEWDWNT"/>
    <dbReference type="OrthoDB" id="67750at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037383">
        <property type="entry name" value="CCDC87"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120048" checksum="4B70A0849A04BCCC" modified="2023-02-22" version="1">MATVEGDSKSWSNAQALQKKEELYTMGKLGFGTRDLQKRYEDILGPLTLFAPYFHEKAAEKVELDIERPVTPIDESIKTPPTTFSQLAKLIRRRIAAKPEVTHITMEDQHTLAGIIMGEVNCIWPDLRRQVDDPFLTANENKELQRRITVHIVTVCEQLFLHYVEKAKILDERGVFSKRANMSRLNAQLSLDANKFLNILAVRRHIVADIRGVLSDSEEEYPDDAPPEEEVAPLSYQKLIETSRPKRKKRYRQTVDREVRDLNRQMPAIQSHKVLDYLPDVDILQRGLLEQNSAQRRASIHAARMQGEKEAHRRRSIMDQERKPVFHRKMRRAKSLEVFPVETIFEDLGIEYNTVHKRRPSLEFDPKLPEKPKTTEEDVSKSKDSREYFQQDLKKLSRYRSARDEGKDEQLAEDEDLPPLLQAISLTDRADARREELRKQLKKIEEERAIQERNERIEISEPTHPQPATVTTRMPNKSVVRTSDVRVSERVSLSSITLKLNTTVFNELNDDVNGNTIKKLDSNLFRGQEINEVYREIMKTLSTDHLAYDQDKFMEQSSSYHALANHTILASSMLQKRGQDRVLNPVLTKTETPPWGDDREEWSKSPIFNATFAKKPTAQQGYTLATSTLLESLTPNINLGGGTPGQDLAGTSSGGLDLDATAMGKPVSQGLMDDRNARSYASWLAWWKNTISCDDYTKYLSTQETDFLGAVFHMYESDDDEGDANKSDKDVLSSSKMAKQRDRDERLKELKNQKTDFQSGMWNVNSVLMGGLGKDPEVEEEEEEPEESEGTDSRARSRRAHSRYLLRTTSRGSAKSTTSSVSKSATLKVPGSRGGDGGKRSVSRLSSRATMRDLTSRLSSTKSLQTSAVPEPLTSQDRLEAIWTSLQMPDNLKLDMAIKYSSDDHMDKLESAIDAWELATEVILQREAILTRLETFERLASDPDRFFQKGHRGSSVARLKEARQRSELYTRLHDLDVHVRDKVQLVHKKFADVPTFQGRPYLNKMKVDCTEMLYWLQQERRQYALDHSTLAQGVKLPVADLSSLSSVTASSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5S9</accession>
    <name>A0A914B5S9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071453.1">
        <property type="nucleotide sequence ID" value="XM_038215525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215525.1">
        <property type="protein sequence ID" value="XP_038071453.1"/>
        <property type="gene ID" value="LOC119740264"/>
    </dbReference>
    <dbReference type="GeneID" id="119740264"/>
    <dbReference type="OMA" id="LMHACTI"/>
    <dbReference type="OrthoDB" id="10070972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF0">
        <property type="entry name" value="DISCO-RELATED, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="936"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113382" checksum="4424BFC19D7F8581" modified="2023-02-22" version="1">MLVHGQRETHRRGIFTMATSIRCTLPNCSCECFAPGKTQLRTCEQCRHGWVAHAMDKLSSGHAFPSLLVEVVHSDIAFDIASLMLYGTQAAPIRLRILLDRLFSVLKSEEVDRILQGLGWAQEDYARGYILQDQDGKVLQHWSVATREEELVILNQFLRFGETKSIAEVMLQELQTGDSQSVQKKNESDIRAFIERIGGRRNANNTFDIPDVEILPSTPSSSRTLAKPRQDNEGLKPGKTQQSVTQRETSQSSTIPAHNIHLANLEQTVLKAGVVQPTSRSRTRTASLNSNLQTVKRSPTTQLNSTQAERSTSGSSAPTFLSSHVSMFPATTKRFSSFSFKGHRKMALSKRRNWTPFSSLANSKQVKCNTCNKWFYDKGTWKIHFGAVHLKVKYRCKVEGCNMAFSSLRSRNRHSSNPNPRIHRFVHNSRRGNKRRGGLQREDLQLQDRGQDEQGNGIGEEDVTMVTDDVTILSEEANKTATVDDGDNILVGEEGEANGEGEGEGNCATDVAFLSPNNSASQATSPDETTKHQNSSDDNLVMDLVKEEVEDSTVKSNLMETQPVPEPSQPSRGSPSFTVHHFKKRKSNAPRKVTILKQEEDEDCQVEGVIFKTEDTEAQNEDMQDAEEEETGIDLEEIAEYQTTSPQEDRDPPSNEYHYVPTGAFSQKGQTSSGGVSIIRSQNIENMHLEQDSIRNQVAEQLGIGIDTCYFINDEGLPSCYLCSKTFQSKQTVKVHYQNVHLKLMHACTIEGCNAMFPSRRSRDRHSTNFNLHRKLFEKGVPLKDSYDQTQPLNQTYCPPMGNAPDLAQSSNHSLSDSNSTNSSEGVRNRHKQLRLDTSLNVENIDNSILEPSPNEIDLQLTRQELPSSTKHRYTMQDSNPTSSSFSASTPQQRYIMQVDQNGLSPLAYNHTYNSPSAAPATSPKDLYPVKFVGNLICNICKKAYSTKDTLRTHYKNIHLREMHKCTVQGCNLMFSSVRSRNRHSQNPNLHRHCVGSDDNPGETDHVDLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6K9</accession>
    <name>A0A914B6K9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable oxidoreductase that may play a role as regulator of mitochondrial function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with COX5B; this interaction may contribute to localize PYROXD2 to the inner face of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071097.1">
        <property type="nucleotide sequence ID" value="XM_038215169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071098.1">
        <property type="nucleotide sequence ID" value="XM_038215170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6K9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215169.1">
        <property type="protein sequence ID" value="XP_038071097.1"/>
        <property type="gene ID" value="LOC119739993"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215170.1">
        <property type="protein sequence ID" value="XP_038071098.1"/>
        <property type="gene ID" value="LOC119739993"/>
    </dbReference>
    <dbReference type="GeneID" id="119739993"/>
    <dbReference type="OMA" id="GLYHCGS"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668">
        <property type="entry name" value="PHYTOENE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668:SF103">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="273"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="598" mass="65303" checksum="B06446198A21DEED" modified="2023-02-22" version="1">MINAVRAAFHQRGQVKPLIGCSYHVTSRCFSKSSQRCRSVGQDALTQEYDAVIIGAGHNGLTAAAYLQKAGLKTLVLERRHIIGGAAVTEEIVPGFKFSRCSYVLSLLRPDIYKDLELKKHGLKVHIRDSYAYTPLLEDPGPNGKPRSLLLSCDQKKTYEQIAQFSERDAKRYFEYEHQMTEIAQALGPLLDAPPVELSTLGDGTMSDRMDMWPGLKAMLQTGKALGKNLPQFYELLTAPMDKILDRWFESEPLKATLATDSVIGANVTPKTPGSGYVLIHHVMGEAEGIKGAWGYAEGGMGAVSRSIANAAEAHGATILTDKPVSTVLLDSDQRACGVVLEDGTEVRSKMVLSNATARITYLNLTPREALPKEFIEEVQAIDYTSPVTKINVAVDRLPDFKASPTGQTQQPGPHHTCTIHLNCESTELLNEAYQPCQTGHIADRPMIEMCIPSSLDRTIAPEGCHVLSLFTQYTPYHLADGKEWDEEAKNEYADKVFNCIEDYCPGFKSSVIGRDILPPPELEKIFGLTGGNIFHGAMSLDQLYFARPVMSASYRSPIAGLYLCGSGAHPGGGVMGAPGRNAAQVASKDLKRQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6U3</accession>
    <name>A0A914B6U3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071926.1">
        <property type="nucleotide sequence ID" value="XM_038215998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6U3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215998.1">
        <property type="protein sequence ID" value="XP_038071926.1"/>
        <property type="gene ID" value="LOC119740631"/>
    </dbReference>
    <dbReference type="GeneID" id="119740631"/>
    <dbReference type="OMA" id="QRVKGVW"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="399" mass="44087" checksum="70DD66CC3DD8D7C8" modified="2023-02-22" version="1">MGILRQIHIVFEDDVAEFSHGGVIKGAVVLDVDGDRDLGLQRVKGVWIQFKGVAKIEWTNTSYNRTSGTTESDFHTQREDYLKKTIVLFGTGRFDRDIDNLSIPPGRTSHPFALPVPSEPLLPQSFQGIYGYIRYTATATVSVKRMRVNTETKTTRPFIMTGPKVDLNIIPSIETPVKTRISQSDCCGCGTMVERVITIGLPKRGYVTNDVIYVVGKIDNRDGEEEIFFDATLVQRIIFTCGKHTRTKEYSLCRASKSVTCLRGWVTDFKVGPLHLATSGPPSGVPGCDLIDVEYYVKCSGCKFTKTFPVIVGTVPIRGATPARPTADSFVPVPADTVALHGTRAVHAPITTDGSSKESSDESEPDETKRLFRASPPDYDFDSLSPPNYHQVMKTFQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7K5</accession>
    <name>A0A914B7K5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071412.1">
        <property type="nucleotide sequence ID" value="XM_038215484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215484.1">
        <property type="protein sequence ID" value="XP_038071412.1"/>
        <property type="gene ID" value="LOC119740240"/>
    </dbReference>
    <dbReference type="GeneID" id="119740240"/>
    <dbReference type="OMA" id="PHFFNIG"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038115423" evidence="3">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="19186" checksum="5F595BB71F697F61" modified="2023-02-22" version="1">MFSIRTVLFLSCAALAMAHPTFFQFRTPEGGGEQAEAEQPLMAGPAGPYPMNQVAGQQVASPSYDYGGGDAGAGGTTETESNESNDGDTGAAGSIGGGEIDGDTADNEAGEMEGGNAAENAAADSPDVVQAGGASGAASPNSLDGGPGLAKREAKSSAGQQAGIAVGVIATVGLAAGIGYFVYRKRRAAAYGARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8G9</accession>
    <name>A0A914B8G9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Exhibits 3'-exonuclease activities and apurinic/apyrimidinic (AP) endonuclease (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072451.1">
        <property type="nucleotide sequence ID" value="XM_038216523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8G9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216523.1">
        <property type="protein sequence ID" value="XP_038072451.1"/>
        <property type="gene ID" value="LOC119740986"/>
    </dbReference>
    <dbReference type="GeneID" id="119740986"/>
    <dbReference type="CTD" id="128387"/>
    <dbReference type="OMA" id="HTHLDMQ"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317">
        <property type="entry name" value="HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46317:SF1">
        <property type="entry name" value="HYDROLASE, TATD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="31016" checksum="BB2B4B70B524F8BD" modified="2023-02-22" version="1">MDPDSNDYMYIDAHCHLSAGEFNEDIGDVIERAKQVGVRAALVVAEHQGEFSRILELSQQYAGFIMPCLGIHPVQGDPTKEQRGVRHSDLEGAVEFIEAHSDELVAIGEVGLDFTPRFVKTDQEKQEQREVLIRQIELAKRLHLPLNVHSRSAGRPTISLLKEHGAEHVLLHAFDGKPSNAMLGVECGYYFSIPPSIVRSEQKQKLVKHLPLDRILLETDSPALAAEKQTRNEPKNISISCEYIAKIKNVSSEEVMRITAENALRLFPKLSQLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAK3</accession>
    <name>A0A914BAK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073111.1">
        <property type="nucleotide sequence ID" value="XM_038217183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217183.1">
        <property type="protein sequence ID" value="XP_038073111.1"/>
        <property type="gene ID" value="LOC119741436"/>
    </dbReference>
    <dbReference type="GeneID" id="119741436"/>
    <dbReference type="OMA" id="PPASTIF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34647" checksum="DF7A0DA1DB2584D3" modified="2023-02-22" version="1">MDLKATLDDKSAFNRAISMCFRGLAVIMSSPMTQINPFPAARKFKNEVSESIRFLRETGRRCIEERLRAMEKQEEVPNDILTHILKEIDQFKGDGQFDMEGLVDEFLTFFIAGQETSANLLSFTLLELGHHPEIMHRLKTEVEAVLGDKEYLEYTDISQLTYMMQVFKEVLRLWPPAVGTSRELSCDVTVKGYKVPKGSIVVVNTYVMARMEEYFHDPLQFDPDRFKASDDKSQYAYFPFSLGRHNCIGQQFALIEARLLLARLLHKFNFDLVPGQAHEILDEVTLKPMGRCRNYLRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB82</accession>
    <name>A0A914BB82_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073100.1">
        <property type="nucleotide sequence ID" value="XM_038217172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB82"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217172.1">
        <property type="protein sequence ID" value="XP_038073100.1"/>
        <property type="gene ID" value="LOC119741427"/>
    </dbReference>
    <dbReference type="GeneID" id="119741427"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="498" mass="51914" checksum="108FDBE5C4C39FF3" modified="2023-02-22" version="1">MSPNNNEKEHRHLGTSSGNDLNVTTTTPKPTSISVAGSPTTGNASRQATGNEEATTSSSNLSSPESASEVSPKLSMKEKVTQHENFMRVPTAAPKPTSISLAGSPTTGNASRQATRNEKATTSSSDLSSPESPSEVSPKISVKEKVAQHESFVKVSTAASKPTSIPVAGGPTTGNASRQVTRNEETTNSSSNLSSPEFASKLSPKISVKERVAQHMQHENFVKVSTAAPTPTSIPLAGSPTTGNASRQATGNEEATTSSSDLSSPESASVVSPKTSVKEKVAQHESFVKVSTAASKPTSIPVAGGPTTGNASRQATGNEEATTSSSDLSLPESASEVSPKISVKEKVTQHENFVEVSTADPQEMSPNNNEKEHRHLETSSGNDLNVTTTTPKPTSISVAGSPTTGNASRQATGNDEATTSSSDLSSPESASEVSPKISVKEKVAQHESFVKVSTLVTVWNSAPHLEWIKPLVTGLATCVLTPMWSMWLTFHGDLARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBF4</accession>
    <name>A0A914BBF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073553.1">
        <property type="nucleotide sequence ID" value="XM_038217625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217625.1">
        <property type="protein sequence ID" value="XP_038073553.1"/>
        <property type="gene ID" value="LOC119741743"/>
    </dbReference>
    <dbReference type="GeneID" id="119741743"/>
    <dbReference type="OMA" id="HTIDLFF"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="567" mass="65696" checksum="7C2ADA931887848D" modified="2023-02-22" version="1">MPEDKSTEDQSAKTTGYSDRSYRLKRFCRRRFKIHGFARLLFRWKASVYKLLWREMIVFLGFYGVVSILYRFALKGTTKSNFEKLAFYAYDYTKVFPISFVLGFYVTVVFDRWWTQFKAIPWPDRCVYNIAAHVLGNDEEARIIRRTLVRYLNLSAIMIFRAGSKRVKKRFPTLTHIVEAGILTEEEKNILKDLPSTHPKYWVPCVWFVNLIRMTRKQGRIVSDPAMKTIVDELNNFRDKCDELYGFDWIIVPLVYTQVVTIATYSYFVACLLGRQYLDPEMKFEGHTIDLFFPGFTLLEFVFYVGWLKVAENLMNPFGEDDDDFDMNFIVDRNLQVSFLTVDDLYEMSLPIVRDQHFDITVPDIPYTNAAIKNKSKPWQGSASKVRLSRRDMAFTSMPHKVFTEEDEVMTCKLHTNSIKKKNNNGRSENTSDLNGSPNEDGNGRESSSNSFSHFKRPPPAYSTFVPSNLQQTGSRPPEELTVPPKKLSRSTGERRKDASHAHQSQVKRDRAESAAATEEPPSNSRSRQHEERDVRDCSSEDDDECSPLSNSSYPVDLNQIVNESVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCT5</accession>
    <name>A0A914BCT5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073859.1">
        <property type="nucleotide sequence ID" value="XM_038217931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCT5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217931.1">
        <property type="protein sequence ID" value="XP_038073859.1"/>
        <property type="gene ID" value="LOC119741960"/>
    </dbReference>
    <dbReference type="GeneID" id="119741960"/>
    <dbReference type="CTD" id="388021"/>
    <dbReference type="OMA" id="DEFRGHC"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24874" checksum="F1FC3CB8655CDAD6" modified="2023-02-22" version="1">MGIGNILMLFQVTTYLLCTIFSFFVFAPMAVNKNGDFLGNCLLFATGSIVQEQIVISSWGPAGGCNFAIAVGVFAMLVSIAQLVRLSFHVYYETDSSFLGAFVTLIINAVMTIMVFASAINVTRGYSVWCQLINQVSGCSVAGIIPEIWTLVVYNSGPNFKPDNYAVEIGMVMFGLWTELLLWIVICIYSVVKLVKYHQQEHIFRSLGRERERLIGRYTQPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCY1</accession>
    <name>A0A914BCY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073909.1">
        <property type="nucleotide sequence ID" value="XM_038217981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217981.1">
        <property type="protein sequence ID" value="XP_038073909.1"/>
        <property type="gene ID" value="LOC119741991"/>
    </dbReference>
    <dbReference type="GeneID" id="119741991"/>
    <dbReference type="OMA" id="PPYNDEY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="267" mass="29472" checksum="78C2A90F895A6E49" modified="2023-02-22" version="1">MQWNADTWSATTSVETGTTSQLFASRTPSLSSVYNKCSVVGESGAGPGGATHQPVPLTCRYPYYPNNLDPGSSSSALASISPYGDDFSVWNSFDFSSATGSQRYHSPFASPAAPTPLNPAAAAAAAAVSSHQHTRDSYLSGASGAGGYSSVSHRSTNYPLSVSGSSNHLSAWVSSVTSSPRRTKRRPYSKLQIIELEKEFQDNMYLTRDRRTRLAEVLNLTERQVKIWYQNRRMKMKKMTEREKQEQQQIEREKMALGSKYFATHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD19</accession>
    <name>A0A914BD19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073740.1">
        <property type="nucleotide sequence ID" value="XM_038217812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217812.1">
        <property type="protein sequence ID" value="XP_038073740.1"/>
        <property type="gene ID" value="LOC119741881"/>
    </dbReference>
    <dbReference type="GeneID" id="119741881"/>
    <dbReference type="OMA" id="MTDWNAQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000026">
        <property type="entry name" value="uncharacterized protein LOC100182860 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="652"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="751" mass="82337" checksum="93FF10C31BFFFD26" modified="2023-02-22" version="1">MSTACNVLLGGLFYIVLVQVIVLPGVVTTTFPFQDDSLPWDERLDDLMSRLALDEMTLQMARGGAFKNDPAPPIPRLGINPFIWDDECLHGDMVYNATSFPQSIGLAATFSTDLLYRVAEAIGSEVRARHNNLTQHGIYQTRGGLGCFSPVINIMRHPLWGRNQETYGEGPFLSGEMTRAYVTGLQGNDSRYVRANAGCKHYAAYDGPDNYPVSRFTFDAKVSDRDLFMTFLPQFHECVKAGSYSIMCSYNSINGVPACANTRFLRDILRDQFGFQGYVVSDAGALRAVYAAHKYTSTPLETAAVCVKAGVNLDLTTVVANVYTYITEAVLKKMVSYDDVVALVRPLFYTRMRLGEFDPPARNPYTKLRAEDVVESIAHRNLAIEAAVKSFVLLKNDGILPLKSILKLAIVGPFGNDSGQLFGDYAGTPLPKYVTTPLAGLQPLANETRFAAGCNNPLCAVYNQSSVVQAINGSDFVVVCLGSGVTVESEGRDRRDLALPGSQLQLLQDAVKAANGKPVVLLLFTAGPFDISWAINNTAVPVIVQCFFPAQATGVAIRNMFTNYLGTNNPAGRLPYTWPASMDQVPPMTNYSMVNRTYRYFSGTPLYQFGYGLSYTKFEYLKFVVERVSIFPCDDVFVNVTLRNVGAYTGEEVVQVYIQWLDATVPVPKIQLAAFKLITITTLQTATVILSIPARVRAAYTDRLVLQPGRFDVFAGGQQPGPSTGGRLNSNVLMGRFQVDGPETDLARCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDM0</accession>
    <name>A0A914BDM0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038073532.1">
        <property type="nucleotide sequence ID" value="XM_038217604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217604.1">
        <property type="protein sequence ID" value="XP_038073532.1"/>
        <property type="gene ID" value="LOC119741732"/>
    </dbReference>
    <dbReference type="GeneID" id="119741732"/>
    <dbReference type="CTD" id="2592"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="15">
        <location>
            <begin position="185"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="321"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="40877" checksum="4968A5CC065B85D4" modified="2023-02-22" version="1">MAEAFDPKEHQHTRYNPLKDEWVLVSPHRMKRPWKGQVEKIPDENIPRHDPKNPLCPGATRAHGDVNPEYTSTFVFENDFPAMLQAGAPEPGPSEHPLFQAKSAVGTCQVMCFHPWSDITLPLMSLVEIKAVVDKWADMISDLGSKFTWVQVFENKGAVMGCSNPHPHCQVWCSTFMPNEPRVKDKNQREYYKTHGIPMLVEYVKMEAEKKERTVVENDTWLAVVPYWAVWPFETMLLPRRHVLRLPDLTDKEREGLADIMKRLCTKYDNLFETSFPYSMGWHGAPTGEALTDDNSHWQLHATYFPPLLRSATVRKFMVGYEMMAQPQRDLTAEQAAERLRNLPDVHYKEKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BE63</accession>
    <name>A0A914BE63_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BCAS3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074359.1">
        <property type="nucleotide sequence ID" value="XM_038218431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BE63"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218431.1">
        <property type="protein sequence ID" value="XP_038074359.1"/>
        <property type="gene ID" value="LOC119742491"/>
    </dbReference>
    <dbReference type="GeneID" id="119742491"/>
    <dbReference type="CTD" id="54828"/>
    <dbReference type="OMA" id="ETHTAKR"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022175">
        <property type="entry name" value="BCAS3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12490">
        <property type="entry name" value="BCAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="4">
        <location>
            <begin position="52"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="BCAS3" evidence="3">
        <location>
            <begin position="619"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="109191" checksum="EB0BA87CFCDE4FAD" modified="2023-02-22" version="1">MAYQSPSKRAAASSRAAGVSVKAQPVSDKSYMATVVDFLQDAYSGNKAEDKDKILWVKFERACSPRGHLSNPHYVNQEGLEEPIFLVIGYANGVQIWSIPPSGDAQEVLSLRQGPVRILRILPTPYINSIRNHQQDKRPLVALCDGASSSQPFCSVSLLSLKTGEQVHNIAFKTPVCDVLCNRRLIVVALQEKVAAFDAVSFKSRFCITSCYPASSPNLNPLALGTRWLAYADRKLVPSHQSGGGVCRESSQSYKATVIHAAKAITKGISAFSESLGKLATSKLSTSPPRQESPTDKPSAAPLNAKHGTPGVVTVIDAASVEGEFNVTEDTSSDGIVAHFPAHINESISALTFDSSGSLLFTAGSQGHSFHLFRLMSHPCSSGLGAVHHLYTLYRGDTAAKVQDVSFTNDSRWVAVSTMRETTHVFPITPYGGLVSSRTHTPAKIVNKESRFHKSAGLDELVDTGRGSPVHGLSESPTSSGFHSPEPISSLSHSGALNNVAVSNPRLPPYPPPVTVTPLVQIKQPAILASVGGAVAGMTGNATRPRSASSQTAAVSDYVCISTCFASSRGHFVASSKGTREKNDGGKQTSVDSLFIMGCHGNLVEHLLEPKMLPGSAKKSEDGALELSVTEHAHWSLQRGMNWCEHRPPLSGLNHLLLTNDAKHTAANTAGSMLNSVPRSESSDSIRSAHSSPDSDFDEPWLSQVEMVTHAGPHRRLWMGPQFKFKTVPQPSSTTVLSSTSSALLSDGLETNRTAMEMTQDDVDLKSLRIQPLRSDPVPTPQLRSSERSAQPLASSQEASSLPTSIEYGSDAKKRSQAGKAMGPSDSEAAAKPPDAVTDPETDRQAQSKGRRKKKKRGKNSAKDMRQTAEGDVAEELAAGPECFPREIEDKIEILNPKAKQDLNRVEHKGAFDQAVNLLEVSCGSWPENSYQRGSEIVEERLRQTIADAMAESPMMSRTPPTRHKEREVLLDNPDLLSSSAGSADSAVHSYEARGSPAHSMDHILVFPPASGSPDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEK8</accession>
    <name>A0A914BEK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074305.1">
        <property type="nucleotide sequence ID" value="XM_038218377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218377.1">
        <property type="protein sequence ID" value="XP_038074305.1"/>
        <property type="gene ID" value="LOC119742448"/>
    </dbReference>
    <dbReference type="GeneID" id="119742448"/>
    <dbReference type="OrthoDB" id="6118651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31741" checksum="A3D5D3AFE0047457" modified="2023-02-22" version="1">MQEGSPGRRGRARITAEEYNHSLSKLVSAKRRVKPSRKAAFMAAFPVKASPRLHSDEDGASVLPLKEASVTHPEHSKTATTDDTTSKTEMKSPVEVRRKLQVFVRGLLLPKTVCLQLDPETSVSDLKALIQNENGIQSQDQHLYIGRNFQLCDLLSLCDHGIQQDQNIELRIGGLLGGAPLEEEQLRSIYFLNLSGRLGRQWKTLAIYLGFLDEELDAFEYGREELNQQSFKMLNTWWQKQDNPADAAEKLRDALKDTGRADLALQVNVQGVYCPLTGLVKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEM9</accession>
    <name>A0A914BEM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074325.1">
        <property type="nucleotide sequence ID" value="XM_038218397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218397.1">
        <property type="protein sequence ID" value="XP_038074325.1"/>
        <property type="gene ID" value="LOC119742464"/>
    </dbReference>
    <dbReference type="GeneID" id="119742464"/>
    <dbReference type="CTD" id="54475"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="52956" checksum="55773515F5752473" modified="2023-02-22" version="1">MEEEGERILTQFVSETGETTGDPFDLPVNVTTEKLQLICNAILQKEEAVPYSFFVNDAEVTTSLEETLKTQKQETEKVLNIIYQPQAVFRVRAVTRCTSSIEGHAEAVISVAFSPDGRYLASGSGDTTVRFWDVNTETPHFTCKGHKHWVLCIAWSPDGRVLASGCKNSQILLWNPDTGKQVGRPLTGHRQWITALAWEPLHSNANCRHLASSSKDGTIRIWDVVLGTCLRSLSSHLQSVTCVKWGGEGLLYTSSQDRTIKVWRAEDGVLCRTLQGHGHWVNTMALSTDYVMRTGAFDPTKASHVYRTVTETAEELSKLALERYNSVKGTEPERLVSGSDDFTLFLWHPAEDKKPVARMTGHQQLINEVAFSPDTRLIASASFDKSVKLWDGRSGKFITTLRGHVSKVYQVSWSADSRLICSGSSDSTLKVWNVKAGKISVDLPGHADEVYAVDWSPDGQRVASGGKDKILKIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJA3</accession>
    <name>A0A914BJA3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075911.1">
        <property type="nucleotide sequence ID" value="XM_038219983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219983.1">
        <property type="protein sequence ID" value="XP_038075911.1"/>
        <property type="gene ID" value="LOC119743561"/>
    </dbReference>
    <dbReference type="GeneID" id="119743561"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="573" mass="63960" checksum="C63EA493E20EF866" modified="2023-02-22" version="1">MQYEDILNHIGPFGKYQKLLVFALFLVIIPPPFHFIGQVFLAANTDHWCAVPASQMINCSQLQLAECQEEQKSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNMSFNSTDVISCDAGWKFDHSRYKSTINEDFSLVCDRQDLPAYAQSVWFAGLMVGSFVWGSVGDWIGRRKTFILTVILVTISSTVTSFVPNFTAYTAMRFFTAACAYGIYLMIYVLASEIVGPKNRVGATTVLFLAFAVGYMILSLLAFLLKEWRHLQLAISLPFVLTFLVIIVFPESPRWLITKGRYKEATKIIEKIAKVNGTEAPEDLLDKLSEDSKEDKKQPSRIPVTQLDLIRTPNLRKKTLILWVDWFVVNMVYYGLSLSTSALGVDDYLAAFVSGAIEIPSNLFCWYVMNRFGRRITLVAFYIFGGVFCLITIFIPLGAARAAVALLGKFAISAAFSHIYIYSLEIYPTIIRSIGIGTSSMVARVSGILCPIILILGKYWKPLPLCVFGGSAIIAGVLSLMLPETMGYSLPDTIQDGENFGKGRSFQLCVKGNDDGENESPTQAPIDYLPLSTMDQTPKQPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMS3</accession>
    <name>A0A914BMS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077245.1">
        <property type="nucleotide sequence ID" value="XM_038221317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221317.1">
        <property type="protein sequence ID" value="XP_038077245.1"/>
        <property type="gene ID" value="LOC119745095"/>
    </dbReference>
    <dbReference type="GeneID" id="119745095"/>
    <dbReference type="OMA" id="CNANETE"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF27">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="26608" checksum="CB89BD218C71F08A" modified="2023-02-22" version="1">MSRAAGPDDIPPEVLKNYDLDAIVLEMCCMALMDNQKPLQWSLYKIIPVPKAGNLSYPDNYGGISFSCIIAKIVMYANTLAKAVTPDGETDLFYTTAGVLKGNTLEPFIFNNVLDHALGRAINGRETDLRFTVTPRRSKRQPAVTETDLDFADDIALMSDQVEQAQVLLYLVEAECLKVGLRLNTKKTECSIYNTPEHIPLKTLKGRELNEVPDFKYLGAWINSSDQDINIRNVMEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNT4</accession>
    <name>A0A914BNT4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077152.1">
        <property type="nucleotide sequence ID" value="XM_038221224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221224.1">
        <property type="protein sequence ID" value="XP_038077152.1"/>
        <property type="gene ID" value="LOC119744999"/>
    </dbReference>
    <dbReference type="GeneID" id="119744999"/>
    <dbReference type="CTD" id="51046"/>
    <dbReference type="OMA" id="KWINGYW"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="460" mass="52283" checksum="850E168984ADEED4" modified="2023-02-22" version="1">MLLRRSTCKKCKKLLLLFMIGITVCLGFVLHTSPESIHFDQLQQTYEEFSLNGAGLTTQGPNESLSPPISQRVARSPPNRGITIRLAVSFKAKRVTVPAGPDQAGCEVPFCVHQSSKGIVRFIGIVKNNRSPSFYHECRSEGEDDEPESDSAKARLDAILNRKWSFNQEAAEEARKDMRQYFNPYDVITMTSDDVATGRLRRFYLSKKLSVNLVPPGLHRLLPKKLLFRNQHYKKCSLVGNSGVLRNSSCGSQIDSSDFVVRCNFATLKGYEKDVGTHTDVVTFNPSIIEKYNKLSTKADGARFAGDLKNYRERYVLWVPVFNRQYVTVALRTLLDFFDKHLGFIKNVQLAFPGNVLPDISDYWASKGVDEERISTGLLMYNMASALCDEIHMYGFYPFPEFNGKPIPYHYDHAPDRVGKKFDYGYKRFHELPDEFVYLKKLHRAGIVKLHVGECPNAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ69</accession>
    <name>A0A914BQ69_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein 27</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078105.1">
        <property type="nucleotide sequence ID" value="XM_038222177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ69"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222177.1">
        <property type="protein sequence ID" value="XP_038078105.1"/>
        <property type="gene ID" value="LOC119745656"/>
    </dbReference>
    <dbReference type="GeneID" id="119745656"/>
    <dbReference type="CTD" id="253769"/>
    <dbReference type="OMA" id="FAQFYYI"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042411">
        <property type="entry name" value="WDR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="617"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="102007" checksum="49219D195D6038E9" modified="2023-02-22" version="1">MAAVHQSTLTTPFAPSHLQLGCNGVYLALPVAKSVGVWSLQSLSSKPLVLEAHKKKLSCLCFGRQHNPTLLCSAAEDYIIVWNVEQARNTYDLGDQIRGQIIGQCLGHVQYCSFSYDDALVAVCIGCEVLILDSKVERLDTTLEGHMAPVTCAEFCPYHPATLVSVSEDRTFKIWDITRGCLVYQSCIISASPFLSLAMNTNSECFAVGSSDGQVRIFDLTEGNGYRCLHQLDIAKLLRTQRETKELDKNSSTASGPRTISSHPAWKRPENDQPIADGTPDDSDFSSEAGEAILGLHFTTKVASTDPSSGVAQSKPPSLLPDDSLIEELLDESPMLVVGTPGALLQINTHSFEMATFIDFQDPIPSGTDQHYIALSGSYAFAQMANSDSRTWCIIGSVFENAVDVIQLRTPPPSKLSPPPSKLSPASIPSLLDNLTLETSTSTSSPQDDDAEQLTVISSAPLSETSVLRSEMTSKPKELNFKTKPQGGKTGTKKPSGSSASGVQDQALTFKSKIKSSGYTGAPRAKMFSPKTNVVKTSSAKREKAGSAGAASRSVTKQYPIDADPPTTVKTKIDVGNQSVPINSIAFSGDGQNLACALANKSAQLFKMPLTGKGTSFTGHNAAVNTVHWSHDGQWLLTAADDKTARIWSKSASDPVLTLSHIDRSVGATDAEKLRTADKRTDCSPTQGSNRVFAKEVKAARFYYVDKFLLLASGGALYLHKFVLDTSVDDIKRYQSNSRYKLVKSFQLEQAQQITALSAVNGFHSYIVMCAGSDKSLEFFDMNVGRSIRTVPTAHSRPAHCICQNEGSAYVSHPPSAYDLFLTAAVTDSIKLWDLRTNRCVKRFEGHMNRAHRCGVAISPCAKYIATGSEDKSAYVFDIRTGTYIHKLSGHTDVVSDVAYHPLYPEVSKPPCRTCTQIWTESQKLQLSPKITCEAYEVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRZ3</accession>
    <name>A0A914BRZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methionyl-tRNA formyltransferase, mitochondrial</fullName>
            <ecNumber evidence="3">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-tRNA(fMet) + (6R)-10-formyltetrahydrofolate = N-formyl-L-methionyl-tRNA(fMet) + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:24381"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038078944.1">
        <property type="nucleotide sequence ID" value="XM_038223016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223016.1">
        <property type="protein sequence ID" value="XP_038078944.1"/>
        <property type="gene ID" value="LOC119746208"/>
    </dbReference>
    <dbReference type="GeneID" id="119746208"/>
    <dbReference type="OMA" id="QPQSNEG"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12230:FF:000003">
        <property type="entry name" value="methionyl-tRNA formyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="12">
        <location>
            <begin position="300"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="46175" checksum="0C9D4769D7C78B1D" modified="2023-02-22" version="1">MQLAPGDCNFKMTQRKVFPLQVMRSFIQQSTLPVRPFCRSWSSVTTSMKKIPPACKYRLPSLQATAHLHTGQSSGDCDQADYSTDDVRVGPPWRVMFFGSDNFSISSLRALHKNTYGENEGKLVDTLHVVCPETKYIKRRGRTRVISPIWQYCHDNDLTTIPWPIRGEVKGYDVGVLSSFGHLVPGHLIDSFPYGIANIHPSLLPRWRGASPITHAILEGDKTTGVSIMRIMPKRFDVGPILLQESLEIPERSTTESLQGILASKGADMILRVLADLPAFIENGRSQTEKGVTLCGKVVASMSIIDWSQTSSEIDRLQRAIGHQFPLETSWHGNQIRLSKMADPMDTAAWEIKVANPALGEVHYDKATQQLCVWCKDGWVGFGEVTLKKKMTAQDFYNGYLSGKDRGRQYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSC9</accession>
    <name>A0A914BSC9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cholesterol 24-hydroxylase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078422.1">
        <property type="nucleotide sequence ID" value="XM_038222494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222494.1">
        <property type="protein sequence ID" value="XP_038078422.1"/>
        <property type="gene ID" value="LOC119745860"/>
    </dbReference>
    <dbReference type="GeneID" id="119745860"/>
    <dbReference type="OMA" id="NMILLET"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20613">
        <property type="entry name" value="CYP46A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58066" checksum="2DB7A1930A680450" modified="2023-02-22" version="1">MVCLTGLLVSVAGFVLLLLGSLFLSYTLFLHYLHVKYSHIPGPKRSSFYWGNLAEMAQAIADKKLIDDLLFEWSKKYGNVFVFHILHNVSVQVYTPEAARDILVLENFPKWQRGYRALTQVFGQRFFGKSLVTEIDHETWKPMGALFSPAFHRNFLKTCIVQFNTSCDLLLESLSKKADGKTEVNMLDMFNSVSLDCITKVAFGLHVNRLDEENPQLIADIRCAAESAFENFLKPLLWCNPSKSAREYREKGRQAVNRIRKMARDCIMTTMESLNSGQTLDNNILAHILQTSTLSDKNGVITEVELEKMVDHFVTFLGAGQETTACLMASTLLEIVQLPEVVYKMKTEADAVIGDNGYVSFEDLSNLKYTQAVLKEGLRVHPPVSSVPRQLTKDVVYNGIKVPAGSPVAVSMINMARQEEYFEKPEEFIPSRFLNDESFKYVHIPFSLGPRKCIGQQFAMIEARVIMAKLMKYFHFELVPGQSLHFVKMVTCKPKDGCLVYIKPVVPLNHVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTC5</accession>
    <name>A0A914BTC5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078861.1">
        <property type="nucleotide sequence ID" value="XM_038222933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222933.1">
        <property type="protein sequence ID" value="XP_038078861.1"/>
        <property type="gene ID" value="LOC119746134"/>
    </dbReference>
    <dbReference type="GeneID" id="119746134"/>
    <dbReference type="OMA" id="IWSIQKN"/>
    <dbReference type="OrthoDB" id="6154260at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="211" mass="23077" checksum="6252C83B09734085" modified="2023-02-22" version="1">MRDQGDFKSGVKRFAYDGGKSNKSNAANDDWDSFVVTKPIKENKELDELNGIWSIQKNVSLSGLPPKPQGTTVQAAPTGTGFYSRHSQHNSTKTTEGTRHSPGMNAMGQPRNSFSMNPQRSGYSYSQPDSSSPTTTFPRLAPTSGATHYQSQSRYNDTTQPTGNQRHLQGGPVLNSRTQHGMQKPSQYSTGSQQTGGSNRSSRTGNQWPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTN5</accession>
    <name>A0A914BTN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079046.1">
        <property type="nucleotide sequence ID" value="XM_038223118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223118.1">
        <property type="protein sequence ID" value="XP_038079046.1"/>
        <property type="gene ID" value="LOC119746274"/>
    </dbReference>
    <dbReference type="GeneID" id="119746274"/>
    <dbReference type="OMA" id="SMMARIS"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="131"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="621" mass="68566" checksum="1AF0BD0D6F37967E" modified="2023-02-22" version="1">MKFDNILNHVGAFGTYQRRIYFVMTLVAIPSALHTFSPVFLSAKTDHWCTVPELAPYRGNCTALYPSGTPDQCSAFLKNISIPREVDDSGKVSYAQCRRFNLTGLDVVGNSSLLLAQPPIVVGDDDEVGEVVDEVGEGGPAYNQSQGVAQDSVQVIPCDAGWGYDTSQYSSTTNHQYELVCDKAGLTKYAQSAYFAGMLIGSFLIGLMADWVGRKPTFFICLITSFLAGIAQAFAPNMAVFIVVRFFVAIFKTGVYMMAFIIGTEFVGPNIRAFAGQFINIYYAMGYMLLAPFAYLIRDWQMLQVALTMTFAPFILLLPFLPESARWLMSRGRTADAEKILRKMAKVNKVELPAELFEEDKDQEEKLKDTTTRRYTYLDLFRSTNMRCKTINILFCWFVNNMVYYGISLSTSDLGVDHYIAAFVSGAVEIPAYTCAILSMQYLGRRLPLCVYLVASGAACIGATLFSAGAGRATVAMIGKFFITATFGMIYTYSAEIYPTPVRSQGMGLSSMMARISGILCPFILDLSSVWFSLPYFIFGAFAVSSGLLILLLPETRGKPLPESLEDAEKVGKGETCLCLRKCRHGADAGDINMDKEPYESLPKEEPQNQDGGRDMATEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2Y3</accession>
    <name>A0A913Z2Y3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046067.1">
        <property type="nucleotide sequence ID" value="XM_038190139.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190139.1">
        <property type="protein sequence ID" value="XP_038046067.1"/>
        <property type="gene ID" value="LOC119720468"/>
    </dbReference>
    <dbReference type="GeneID" id="119720468"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="126"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="439"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="602"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="16">
        <location>
            <begin position="906"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="957"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="14">
        <location>
            <begin position="999"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="17">
        <location>
            <begin position="1416"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="15">
        <location>
            <begin position="1570"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="18">
        <location>
            <begin position="1728"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="2092"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2127"/>
            <end position="2136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2374" mass="262005" checksum="8C69B5FC5389F121" modified="2023-02-22" version="1">MLQLHPSKFSFSAAKIQHVAIAGNASTRIISPNFPFPYPNYVNKTWIISTEENHKIAIKFFEFRVDTRYDGDFLQIGDGTDVTANQFFQENGFTLPPKLLSNGNEMWMRFITDYWRAAAGFVLAAASVPVTDEDRIVYIGANDTVELASTRYPDYYVNDIQITWIIQTEEARRIRISFTRFSTEYWYDVFQAGDGDSSAHNMFFQWSWYRNPPDLLSAGNTMWLRFTADESYQRQGFLLTASSVPASDNLTCSPNQFDCGHSVCIASSWQCDDVSDCFDGRDELSCGTHEIFLSANETAAISISSIHINSMWLIQTVEDRKVLITYPTGYFSLSGSFVLRAGDGDDSTNNTSVFFEWRRRSRYRSPDLLSDGNKLWITFERGKSFSSYNFDILATSVPLTEALTCSLGDVECGHSVCLINALQCDTIIDCVDGTDELDCDKERLLLIPANETAHITSTSYPSSYPSNLNITWIVQTEMGWKIRIKFSSFSTSTYTYYSGDDLHAGDGSIAANSQFFKWRGYRTPPDLLSTGSDMWLRFTSDEYYSGSGFSLEASSVPSSEILTSCSPSDFDCGHHSVCIPDIWKCDGFVDCLLVAEGDEHNCDKDRVVFLGALETAELGSTVYPNYPNNIEITWIIHTEEDRKIRVNFSDFQTEHLTDFVQAGDGNRSTDNAFFRWSWDRFPPDLLSSGPMMWLTFKSDSSINDRGFFLSVASVPATEELTCSPGEFDCGHSVCISNSSKCDSITDCLDGSDEFDCDNRTIFLDANEVARITSPFYLSRYPRNLETTWTIQTEANRRVLVTFHDFSVSSQRGIFKAGDSGANDTFYVSNWWRFPPNLLSNDRTMWLSLDSDKNWVGGFDLTASSVPSTYTLPCSWRNFDCGHSVCIDGSWRCDGRLDCFDDKDEQNCDSCVGRCFLDGPRTGDCWCDAACEMTGDCCSDYIEHCQGAQMPTTTVQPDVDECNPDAPLHNCDDNAICNDTFESFTCTCRSGYAGNGEYCTDVEPPSITCPADFTVYTDCRKSYSTVSLPDVQSASDNSGQYAISINIGGSIYEVGDTTTLSLGASPHMVRYTATDNSYAADCDTNVTVAEVSDGTFCEETGSPPNCICKSNEGLDCTCFYKNCGHDCSQSAEGVECTGPGVPYPNCTDVDRCDPGHSGPRCDSDSNTLQCPEVDNRCLADGLSSAQISWTLGPSGSSSNVTCTDSLDGATVGTTGGVFGVGTHHVVCSSATNAFPDCLTSFSISEFPSVIVPAVGDQCTDPGLNTSTVTWTEVHAVDAGEVTIDCTDSGDGVGVGVAGGVFGVGPHTITCRAVNDVGCAESKNFTFIVMEGNLVPFGEEIGDTLLSSEPQGPHSVKDLISRTFYPPNFFPFGSKLYEKIYFTDNGVIVLSNDQNLDKRAFPSPQGVTFPSNRMMIAPFWADVKANAFTATDNVFWQVHDQYDPNVNQNMLDVASLIVSANYSGFSANWALSITWRNVKAISPSEETNTFQALLVTDGVRAFVVFNYDPCGMNWDASLLLNNNVIQGFTSGLFGPTVYVDIPDGSRFRPGGIVGNTGKTGRWVYRLDSLPDGFVNPRLSCHDWYHRQEPYPLFAIHYPPFADTCPCSLWNARFDWRYTEVSRSVVLPADGNSGYPAVCYVRLFQVSWIPGPRCCYNLFSRNLVYDVQSARVASVFERYPLGPIFYRANSVNQWKNEEALPRYYCCEKSTLCDLYRTWRPLMTCSWYRPPVWVWGWGDPHIVTLDGLEYTFNGLGEYTLALIKDDDGQRVFELQGRTRQAVDTETGELSQATVYSGFAAVYTDEAKIEIKLSDNAMDLVTTVNGTVVTPTAEGLQFANLQVTRAENPIKVSVMYSDYITFSVGVNNSMADITVLFNEDFKGKTKGILGVWDDDPSNDVLTRNGTLQMGSGQNGTLVERDYFEFGETWRVVEEDSLFFYQSPAESYDSLNDPNFTPDFLQDLIDKAPPGKYNEAKAVCGSSKVCLYDSLALNDTSIGMATLAFNEMNMENMAIATNLPPNITLVDSIEVIVGKNFILQLEAVDPDGDDVTFDLLEIVAGAAITASGRFSWTPEDKTKVKIGFLATDGKANATLEPIVKLCDCQNDGTCLFDQYASGVNIVQDRFGVVLCQCEPGWSGEFCEENYDACADNPCFLNVDCVDEDPPSLNSTCGPCPAGLEGDGKSCQDIDECELYKDQPASGGGLGCDQNCHNILMNFTCSCNAGYLHEDGKRCIGTTTPSGSTDTPGICSCDETTDTVRFCITHIDGMSVTFDAAYLDRTTDEYKNLSSRVINAFSGENMMEICPTDEVLTNTVEFSNGSAITVSFDIRHSVCNEADLAESMACVFLEVGIYLYDVYINESVTSMKTIAVSNLMPSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3T3</accession>
    <name>A0A913Z3T3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046367.1">
        <property type="nucleotide sequence ID" value="XM_038190439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3T3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190439.1">
        <property type="protein sequence ID" value="XP_038046367.1"/>
        <property type="gene ID" value="LOC119720654"/>
    </dbReference>
    <dbReference type="GeneID" id="119720654"/>
    <dbReference type="OMA" id="YDINRTM"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="59183" checksum="15FDB20A973E43EC" modified="2023-02-22" version="1">MAGGLKCNPLTVSLVIVGTLLAITCMFVFVITNVPLDFDTCEEEPGVVIETEIIRYGIVIRVDAESAQPKLFSWSYDINRTMSRVQRQQYSCKHKTKAVKNPQAFRRSCLDEIRRIVPRDHRENTEIYLVRRDTINSARLVPNLASVRSTIASYPFNTSRADLADPSVITDDDLARYRWVAENDALGTVHSDLMKSNDDFTGSLRPTHGLLDMGSISARVTFAVSDGGGVSSSTRSNGARPVQLYGRDYALYTRSFPCYGLLEVGRWFKEQLVSELYNSSFGAISNPCAPSGFTETLSSPRKGSPCSTQTLAQDDRLAPTDAGETERSNQTREERYTLEGVGNSTDCHRRVRMLTLEGEELPEFKGDFIAFFPELPFDVADISGVDSYIDATYCNWTGTPAEAFSREVNSTGVNSCFVMIFLRALIFEGFKIDQTTWERAVIRQEESTTAQDPSWLQGFMAATASEFPPPPGPCVLSEENRLALERKQATVTALILLILGGLLIVGLGYGIACRRGGDNNWVPSPLAMYQFQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3V1</accession>
    <name>A0A913Z3V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046474.1">
        <property type="nucleotide sequence ID" value="XM_038190546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190546.1">
        <property type="protein sequence ID" value="XP_038046474.1"/>
        <property type="gene ID" value="LOC119720728"/>
    </dbReference>
    <dbReference type="GeneID" id="119720728"/>
    <dbReference type="OMA" id="WFGHHCE"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640480" description="Delta-like protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="14">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1022" mass="111838" checksum="33EEA846DD642095" modified="2023-02-22" version="1">MKLVLRLTTLSQVFLLVWATASVQFKFVSFYNSDHNDYDGGCCDDFFGGCDDFCDNYFFVCIDGDDTGPLGTSCDMAAITTAKLHEDNDNFNFPSTIPNLIANPYTIRVDSWSGSMEVFVRVWDLDTQNNDDEIDRDRRTIYKAAARSLSGATWQQYRLGSRSQIDFSFQVRVYCDSYYYGSDCSVHCIPRDDQYGHYRCDSNSGAKICYSGWEGSNCELDKNECLSYPCANGACVNGADQFSCFCSDGWTGTTCNIDVDDCASTPCKNGGTCHDHVAFFTCACPPGFVYADVFCEYDDCAGQPCQNGATCNDLIEQFQCVCPLGYFGDLCEVDIDFCINQTCANNGTCVDRVDGFHCLCETGYEGFLCDVDTDECSSSPCLHNGTCHDLIGKYQCACQEGYEGTHCDLETDECLSSPCRNNATCEDEFAGYHCHCVDGYDGDTCEMDIDECASNPCYANETCVDEINGFWCLRLNLCDYDPCMNNATCVDDYPGFICECAAGYGGKTCDQDIDECASSPCLRGTCTDHLDGYTCLCPPGYGGEKCHSETNECNSSPCLNGTCWDLINGYVCNCTAGYEGVLCQNEIDECASSPCLHQGTCTDYLNGYTCLCPPGYGGETCHSETNECNSSPCLNGTCWDLINGYVCNCTAGYEGVLCQSEIDECASSPCEHGTCVDELNAYRCECDVFYEGTQCDTVIDKPCALKDPPCQNGTCENTNSANDYNYKCTCDDGFYGTNCDIDSKLYGAVVFVTGKLEDKSAFETKLANLLQKLYAPQSRVRRDTGETVSVKVVLTEDYVKSTDSSPLTKVTFLAWTESGYLQKDTIEAWIDGASTDLPAQYGLDIYKGSAEPFTGNPSENWIGSNWYIILVVVVVVASVVAVGVISYRKGYINRAKDAAIKYQGRDRGQSALPLDLETPYNTRIGEGDIAYSTRIRDDAPTLPKRPARPNMVESFNPAYISSCEQPDLCGSAAACADDSGFFVALDGGKEKADNHYADIPALKAEAIAKENPYNEIGHSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4G7</accession>
    <name>A0A913Z4G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046728.1">
        <property type="nucleotide sequence ID" value="XM_038190800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4G7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190800.1">
        <property type="protein sequence ID" value="XP_038046728.1"/>
        <property type="gene ID" value="LOC119720933"/>
    </dbReference>
    <dbReference type="GeneID" id="119720933"/>
    <dbReference type="OMA" id="NSHHESQ"/>
    <dbReference type="OrthoDB" id="10056126at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="585"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="898" mass="103144" checksum="0060ECF452DEF543" modified="2023-02-22" version="1">MFYQVRLLPEDRCLFRFLWRNLQVDKEPDIYEWQVLPFGSTCSPCCATYALRKHAFDHEKDYPEVAKAVDKSFYVDNCLQSLPVETDAKALVQKMRNLLADGGFEIRQWASKVPAVVEDLPPDARSDGCELWLTFGETNSTEGTLGMLWECSSDALLYRHRPISYDCLNMRNMYKILASQYDPIGYLTPFTARARVIVQDLWKTKRNWDDPLEPGDIRDQWQAWESEPPHLTGVKLNRCYTPPNVKTEAAHRQLHIFCDASERVYGAVAYIRTEDEDHNVHKELTLPLDEVILWSDSTTVLTWLQSESCRYKVFVGTRVAEIQTLTDVDKWRYVDTKNNPADDLTRGKTLVDLSQANRWRDGPSFLRLTPDTWPAHPSTSQTEDPSEFKKSTFCGAVVVIQPNLPDPSEHDTWSDLVAATMQHLHGAAEDADPTKLVEQRVEAEMFLYQRAQQDSFPEEIACIQAGKELPRGSRLLQLAPEYDESWGLIRVGGRLRRTQDLPKDTKHPIMMNPAHPITKLIIRDYDEKLLHYGPERILAEIRRKFWILRRREAIRKHQRQCFECQKWRASPQVPKMGDLPPARLRLFKPPFYLTGVDCFGPMTCKIGRRSEKRWGIIFKCMTTRAIHLDLLDSLDTDAFLMAFRRFISRRGKPFEILCDCGTNFKGGDNELRDAFAAMDPIIQQELAKHQVKFVFNPLKAPHFGGTWEREIKSVKDGLRVALNEQSVPESVLRTVLIEVEGILNSKPMGYVSSNVADPDPVDPNLLLMGRHDATLPQVVYPARDLLGRRRWKHSQVLADHFWSGFVKSYLPTLQERQKWRTDRPNLTTIDVVMIVDPALSRAQLPIGRVAETFPGSDGRVRTASVSVRGKTYTRPVARLIRFPEVSDDNIPDGEPNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5B9</accession>
    <name>A0A913Z5B9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047018.1">
        <property type="nucleotide sequence ID" value="XM_038191090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5B9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191090.1">
        <property type="protein sequence ID" value="XP_038047018.1"/>
        <property type="gene ID" value="LOC119721186"/>
    </dbReference>
    <dbReference type="GeneID" id="119721186"/>
    <dbReference type="OMA" id="LEDKYIF"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037939270" description="Glycosyl hydrolase family 13 catalytic domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="34"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="629" mass="72131" checksum="FE06B700FF2EA26B" modified="2023-02-22" version="1">MRCLWMRAIFLFMTTTLSFGSKRDEWWKNTIVYQIYPRSFMDSDGDGVGDLAGITSCLEYFNDIGVGTIWLNPVYKSPMADFGYDVADFKDIDHIFGTMADFDELISKAHQLGLKLLMDFVPNHTSDQHRWFVESRKSKNSTNQYKDYYVWEDPKQDCSDPPHQCIPNNWVSVFGGSVWEWVQERQQFYLHQFLKEQPDLNYANPQVQAEMDDTLRFWLTKGVDGLRMDATRHIYENDKLEDEPLNPDYTDSVPGEHAQYQSLLHTKTVDLPKVYDVTYHWREILDEFSDNPDWPGYPSRLMVVEVYNSHKALLPYYGTSDRRGADFPFNFGLVYLNKENMSGIKIQELVNAWMEDLPPGKWPNWVTGNHDRPRIADRVGITYTRAFNVLNLLLPGTPTSYYGEEIAMGNIWVAFNKTQDPFAINNPNHWENYTRDPERSPMQWDRSHHAGFSTTTGDTWLPVNQNYLSGVNVADQMADNTSTLALYMKLAALRKEQPAFQTNHLKYVIVTENIFSFLRMPDTPGLESFLVIINAGTSNSTDDYSAALKKKMMITEDNSGIVVVSSNMDRNGKPQGICNVHVAAGEAIVIRISVYVINSEPAPSLSPCLILATMLAIIFSGIVFRYQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7I4</accession>
    <name>A0A913Z7I4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046795.1">
        <property type="nucleotide sequence ID" value="XM_038190867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7I4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190867.1">
        <property type="protein sequence ID" value="XP_038046795.1"/>
        <property type="gene ID" value="LOC119721003"/>
    </dbReference>
    <dbReference type="GeneID" id="119721003"/>
    <dbReference type="OMA" id="ANTHESN"/>
    <dbReference type="OrthoDB" id="6782814at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="772" mass="86910" checksum="B23EF2EB80BC1B78" modified="2023-02-22" version="1">MKPNALKLKTSSIFVGVQPNAPLHLPPVSPARRINARFLPTRAPTSPSFRGIRLLRLLPATPGDSPPDIRVPSSPGGREVTRAYDNNTVFIPPASGPVGGRLGEFSQRWSHVTSDTWVLQTISTGYRLEFTSNPPLQPPRRPTPVPSDSARRVALEKEIISLIDKNAIILLPTGSTLGVTSTFFLAPKKSGDWRPIINLRPLNSYIKPKHFRMETLSTVLQSLKRNWWATSIDLKDAYLHVPIHADHQKFLQFLYQGSGYQFRCLPFGLSTAPRVFTRIAKAVAAFLRQKQIHIFLYLDDWLIVGPTFQDTVDALRQTVQLTLNLGFIINVEKSSLIPTQQPTYLGAVLDMTTGRAMPSGERCQTLWDCIGIFRSSPILPAKSWLRLLGLMASLVDLVPWCRMHMRPLQLHLLYHFRPRKDPISKMVPVTPLIIDKLRWWLAPNNLLCGVVFPRPSPAAILTTDASTLGWGAHMDYLSRAGTWSMKESLLHINHLELLAVDKALRSLESEVLNKLVLVKSDNSTVVSYINRQGGTHSPSLCLATWELLSWCIPRQISLQATHLAGKKNILADALSRGRVSPTEWSLRPPVVKHIFNVLGTPHVDLFASHLNNQLPTFCTRHTHPLAWKVDALSFDWSGMHAYAFPPISLIQRVLTKIETELSRVVLIAPFWPRQPWFPRLLDLLVHSPLILPNRPDLLSQPGSHILHPDPSTLHLCAWMLSKSPSDQRDFRRKLRPWQPRADGDPPEELMIVDFSTSPNGVRRELSIPVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7L3</accession>
    <name>A0A913Z7L3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047674.1">
        <property type="nucleotide sequence ID" value="XM_038191746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7L3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191746.1">
        <property type="protein sequence ID" value="XP_038047674.1"/>
        <property type="gene ID" value="LOC119721432"/>
    </dbReference>
    <dbReference type="GeneID" id="119721432"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14027" checksum="2656D654F9E8D3B4" modified="2023-02-22" version="1">MAGEVVDRGLVSNVTAIFATLAVHAVSFLVDPWLMSSLPLAVSTSSLIASGSLMYALVDRQVRDVYGAERMASCFGLMSFLTSPAKLLGGFMPGWIYDATGSYDNAFIILGLTGLAAAVPLAIKIHYHKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z893</accession>
    <name>A0A913Z893_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048017.1">
        <property type="nucleotide sequence ID" value="XM_038192089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048018.1">
        <property type="nucleotide sequence ID" value="XM_038192090.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048019.1">
        <property type="nucleotide sequence ID" value="XM_038192091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048020.1">
        <property type="nucleotide sequence ID" value="XM_038192092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z893"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192089.1">
        <property type="protein sequence ID" value="XP_038048017.1"/>
        <property type="gene ID" value="LOC119722077"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192090.1">
        <property type="protein sequence ID" value="XP_038048018.1"/>
        <property type="gene ID" value="LOC119722077"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192091.1">
        <property type="protein sequence ID" value="XP_038048019.1"/>
        <property type="gene ID" value="LOC119722077"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192092.1">
        <property type="protein sequence ID" value="XP_038048020.1"/>
        <property type="gene ID" value="LOC119722077"/>
    </dbReference>
    <dbReference type="GeneID" id="119722077"/>
    <dbReference type="OMA" id="MPGFKYR"/>
    <dbReference type="OrthoDB" id="5953973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="36254" checksum="865FE1FB0074A0B7" modified="2023-02-22" version="1">MTDVDVQFYGSHHLHLNPFDKMPDVEDEVRNIAGSLIAGQTDSADFESEIVRCQERSYFEGLLDGDAPEISTAFYAKEDGPQNGTSPDDSSHSSEEAKLSQPVVRVQGNGIPASYEVRGLRQHEMPVIGMQIDPRIMPGFRYRVRILSGDSTEMTQETPRYQFRGEPLHLLRIGQGYGKRLTFTSESLNDNTNFFWSDTNPSGYGFGIVAVQTGDEMVLTDLARRPIGTGTVEEASPCQLELGTETLDDRDTGKKALVKRVSVIMKVRLRYTCERHGIRSIRASETVIVRGVAQVIKRSGESKAYTKCIEQLELPHLGECLLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8G9</accession>
    <name>A0A913Z8G9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SON</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048093.1">
        <property type="nucleotide sequence ID" value="XM_038192165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8G9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192165.1">
        <property type="protein sequence ID" value="XP_038048093.1"/>
        <property type="gene ID" value="LOC119722125"/>
    </dbReference>
    <dbReference type="GeneID" id="119722125"/>
    <dbReference type="OMA" id="SWASSKH"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19870">
        <property type="entry name" value="DSRM_SON-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000053">
        <property type="entry name" value="protein SON isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="874"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="111903" checksum="861ADFC9374EDC0D" modified="2023-02-22" version="1">MHCLGKIKMAGLDEVLRSFALQKMQELKEKQRDEDTEDTKPALDECNERQQSSDATSNSNGKDEHNSANKEVKAEMGNDAIQKTTKTSPEQLKSEIDENMKEESKPMQMETSSSKDGKDKKITIKLLTKKIEPEATMHRDAEEEVAEEEMDDVDSSTDSSDDENEGEVKDGKPWRKVYEEGELSPSSESEEEADGVAEGEAEGEGEGEEEANEEANVTKEDGMDSDTSGEIKDEDAKKSKKHKKHKHKKHKHSKGETKEESPKEKHKHKDKSKKDKKKDKQKKEHKSKEKDPDKDKSKDKKKSKDKASKGDEVDKLKKENDSGKDKHKEKSEKKEAKEKKHKSRHKEKGGDSKEEKTKSSSKRKHRSGSRSRSQSPSKSKSTSHHKKRKRSKSRSRSPKTHKHSQSTRLRSREEAYYRSTSPDRYYSRRYGAGSGSRYVQRSRSRSPRSDDEFKIDKAKLLEIAKANAYAKMQSGEFPPYMKLTPKSVVTKVDPKERRSVEELTAVCKEIASKQQDDSDSDDSPINKPVGSDDETDEPFIRHPFKVREAPLGNVGIVMNIRNAVQKPIQDKEMLRLTFPVSSGSQHRKKEDELGPKPYGDWVSIEKKPKMMDPVAKPTTKIMPTPGTETLTPAEATPGVPGVTTAVTAPTVTDPAAAAVAAAAAAAAMPPPPVPPPPTTVAPAPAPEIPTPTPPMPPPTPPAPLTFAGIISPAGALPTSSAIAAASAIPAAVAAAEYASVAAAAAVSKAMAVTVPPAPIGVAAMPPVAQKDQAKEDKVFEEIPNQKVDIAAMVSARLKAARRLEHNPNDVEALSVMHKAQTQIRNWTMGKQKPGMFTGDTGLRTLRPQELANTDPRAQAWAKKNMFRNQAPITGGNKGAMLMAKMGWRQGEGLGKNNEGALEPLALDVKTDRKGLVAEDEQRRKRTAVPKTVFKDLSGKHPVSALMEICNKRKWAPPAFDLVQDKGPAHKKNFIFKVRINNEEYQPSASCPNKKQAKAQAAAVALQKMGLIPPDQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9N4</accession>
    <name>A0A913Z9N4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048493.1">
        <property type="nucleotide sequence ID" value="XM_038192565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192565.1">
        <property type="protein sequence ID" value="XP_038048493.1"/>
        <property type="gene ID" value="LOC119722444"/>
    </dbReference>
    <dbReference type="GeneID" id="119722444"/>
    <dbReference type="OMA" id="LNGCQRQ"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000012">
        <property type="entry name" value="Putative transcription factor AP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="35594" checksum="034B738A993372EB" modified="2023-02-22" version="1">MSSVKKHKPSSMAMETVQNFYDDPHNPWLNKKKTMTLDLVSNGSTKKRASALALLSTPDVQMLKLASPELEKMIISQQGTVCTTPTPTQFICPKNVTDEQAAFAQGFVEALQSLHQTHHAPGDGDDSSGSDEEEDGKVALMQVIQQAPAQNSCIVTTAAAAAAAAVGLEYNPAMPTTTSLPGTTINYPIRTSAITTMSTVDTSVITNNGWSPMAHIKQELEQPQIVPVFNGHGTPPLSPINMESQERIKAERKRLRNRVAASKCRRRKLERISRLEDKVKDLKDQNTQLSSTATKLRDQVCQLKQSVMEHVKNGCQVMLAQQLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAS1</accession>
    <name>A0A913ZAS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048116.1">
        <property type="nucleotide sequence ID" value="XM_038192188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192188.1">
        <property type="protein sequence ID" value="XP_038048116.1"/>
        <property type="gene ID" value="LOC119722142"/>
    </dbReference>
    <dbReference type="GeneID" id="119722142"/>
    <dbReference type="OMA" id="NFMELVC"/>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="396" mass="44850" checksum="F4707972990D46CC" modified="2023-02-22" version="1">MSRIWRRVPIFYGVQNEALKSLIPVRARISSLSRPLSTSARRYDSTEEKEDDAPAERPSAAKNLLSTLTGLKVERNVSSQVGSSARLRSAAADFRDLLGQKKAADEGGSDAGAKTKKPEDVQKMVVETAKVVAQIFPEKEVVESDLLKQLRKHDEATAAGKQGDVEAVSSILSGIKVEKQTAIQRERDRTRSLDERALAGAFGSGFEMTGETQLEDQTSRGQKQRETIRRQHKKTLFDRSRLNIFTPPKDDTQDAQVLAEGESPVPSLWDKEGDKQLKQLTYSTINSGFDEMMKWTEEGKTWHYPIDNEQGLEEEQQVPFHEHIFFDHLLEDLPPVEAIQTFMELVCLGLSQNPYLTVQQKHDHIHWFKTYFKERENVIREAVEADRADEARETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZED0</accession>
    <name>A0A913ZED0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038049305.1">
        <property type="nucleotide sequence ID" value="XM_038193377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZED0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193377.1">
        <property type="protein sequence ID" value="XP_038049305.1"/>
        <property type="gene ID" value="LOC119722956"/>
    </dbReference>
    <dbReference type="GeneID" id="119722956"/>
    <dbReference type="CTD" id="56916"/>
    <dbReference type="OMA" id="ANHEMLM"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="298"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="576"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="933"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124849" checksum="55DC51FFFA298E57" modified="2023-02-22" version="1">MSVKGLPSLLDKFRYQERAPSRFLKLDPSSCSSQSASDSHDTFDSAAKSPTSYNNQGNNANEHATFTISSPSSVQSQDSEVTCIPETPTSIVSSPRSPIISKTKQLTSRYHAKIITDTISSDSEDCGTPKTTMTNIRRKPNIRPLGERKFRLVSTGSEASDSEDDDHSSAAVSSDSKSSSPVFGASSSCHRSEPLTSAGTSAYGPAGSKHSFKFNKTLKLDSTGKQSPIQYTALPSSSESDTDTTTMGSHSHSLSKASLTELETSPPTVRRKRKRRRILSEGQESIDGGVEEEKIETRQKEDVRKLQEMFPEWPAQQLKDTLVSVDWCVEEAVTVMTTKDIDGTYSDDNNSFKGKQVHRKKRRKIERTSDKENKQQWLSKSKMTSYFPKITKPGQQRIKLKERRPDKDVLSSEDETFSLSSDSSDEETSQQLNGDDDKEQSEMNVLILSFFNDATPEELLSISQCSKTKVKKIEALRPYGDYDDLISKFDNTKGLSTSLVWNCHEVFQSQQVMTTLMNNCAKIGDNIQSLICRLLPDQNGETDEGRIEGQVTKQPALLSDKLILKPYQMIGLNWLALMHRQGVNGILADEMGLGKTVQTIAFLAHLMEQGDGGPHLIVVPSSTLENWARELHTWCPALEVILYTGTMEERRDLRNNILDEYLSCNVIITSYNMCISNVDDRSLFRKMGIHYVVFDEAHMLKNMQSQRYKFLMRIRAERKLLLTGTPLQNNLKELMSLLSFVMPNMFCDNAAELQKIFSLAKQKSDDPLKQSTFERERITHARQIMQPFILRRVKSEVLNQLPPKSESIVKCPMIKSQEECYNNIKAMLSQDLRKLGGGAKMNMTKLSCAMMQLRKAANHEMLMRHHYDDSKLRQMAKLMLKEPSHHDADPDLIFEDMSVMSDYELHRLCHEYYIMTPYKLSSDLVFNSGKFQILDKMLPEMKQKGDRVLMFSQFVMVLDIIESYMKHHHYKYLRLDGQTPVCDRLALIDKYNSNEDIFVFLLTTRAGGLGINLTSANHVILHDIDYNPYNDKQAEDRCHRVGQKRDVTVTKLISSNSIEEGMLRCAQYKLQLEQQMTTNDGSDGDAKNATDIARLMKEALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG37</accession>
    <name>A0A913ZG37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050748.1">
        <property type="nucleotide sequence ID" value="XM_038194820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194820.1">
        <property type="protein sequence ID" value="XP_038050748.1"/>
        <property type="gene ID" value="LOC119723914"/>
    </dbReference>
    <dbReference type="GeneID" id="119723914"/>
    <dbReference type="OMA" id="CELPINN"/>
    <dbReference type="OrthoDB" id="6366227at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038076998" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="248" mass="27468" checksum="62943C9108366534" modified="2023-02-22" version="1">MDVLNVLLLIAGFEASVATVCPVGWHRYGKNCYFVIKTKWNWYTAKKTCAASHASLAVPISSEEQTFIWELLQREFYPDGPGNGAWIGCNDINKDGVWQNCPLRGGETNAYQNWREGRPGNQYRYRGADCALMVNSAGGKWGNQYCTNPRYATCELAIIDYNPLFCLQIGSDGRITSPCLTDKHVLMELQAQGLVSCGKACLSHPECSSFNLKDQGQGKMVCQLNDLALQNAAAEDVVEIENCYGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGJ9</accession>
    <name>A0A913ZGJ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050908.1">
        <property type="nucleotide sequence ID" value="XM_038194980.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194980.1">
        <property type="protein sequence ID" value="XP_038050908.1"/>
        <property type="gene ID" value="LOC119724060"/>
    </dbReference>
    <dbReference type="GeneID" id="119724060"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037679347" description="GPS domain-containing protein" evidence="9">
        <location>
            <begin position="32"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1223"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="13">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="1163"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1484" mass="162354" checksum="B2168E925D2939EE" modified="2023-02-22" version="1">MVRTRRRDEGGTGVILVMLLVLIAQLPSVLGQPGHLGCYVDKNDDRALQGDQWTDVSAQSWEWCIANCSRTLYRFIGLESGNECYCGNDVYSRHGNGYGCNMTCEGNAGQTCGGLNQIEVYRVSSGVCSNPYKQPSHGSYHVEYRPYNYDLGDSEYVGARLRYTCHRGYYLPFNTSTVTCVTGDPSSWDHYVTKCPACTSISNCAAGQLHCTTTTDQQCDQCDGDYGSDGADYSSVNNGSECRKQCSWRKDSNACYPGSCTDANCTCSSGFLGPDCMTLGSGQAPVLSEHRATLEGSTTLESPVVNGSTDAVYTNVRDFARIKIYWESSYQPVGLPNSSAGGHPYIHNVSLGVVWARVEAYVNRSTTLIYSIAEQNCSTTTDGVYFSPDNPAAIVVVCEHTFNVNFSSWTPVTGDVLRYDVHSTNGGYLNLYNRDSNNTIITRYYNGQTVSGYSTFTFDFVNPYHCLDVGSGCRISMLNAGNDVTSQTTMTITWQGWADDLAGIKEYNLEVRQLSGNHGNEMTEIFDIPAVYSGVTNSSQNVTLPHVGVSTRVYSIVLTTVDNAGNFRLSRRFVFFDDDPDDVTMQNNASVRLLSATKETDYEWLIDLDSNGGMTSVLLDWTNRFINIHHLNQGFLKPIGSYVNATIDDDYDQNFGQRGRSAVLNALGVTEFRVLSDIDHSGGRTTVNVSDDNSDNWSNEATNTQATYNLTLADGDSIRFWVEARDLAGHFVRDSVLVHADSSPPTIQDFKLIPGLSGISVECTTFDEHSGASTVKWRLFHVDNGTQIEHVSETTPVEHIDPEGCNPATCLCVPIGDCYAKNYNSSFVVDDRAFEYFITLTVTNHAGLVTSQTFKTSPMKTVDEAAEDLVSQSNDTSSIDAGAFDQIADQLDDIVNSQDTSPEVTANVIIVVNNLLQVDTREFNDSESAANSSSRVVRALERQIWNVLAAGKNISAVTTSVAVVASHFNAGALLNGVVFAALSGGGGSESLADEDIGVFHGSDGDIPLVKVEVSIKLPEEILKLFPTGSAVPISFVMYENSNLFHSKQVDNASSTEFPTAIASRIISASVPNVSISDLPYDSPVVIAFHLKPVQVSSPMKNTEQTETCVFWDFNLRHGIGDWSPEGCRTDQLTNGRIVCLCDHATNFAVLVNIHGKKFTSLALDIISKAGCIVSIVALVITIVIYSSLRSLRSKTPSRILISFSLSLLCLYLVFVAGIEQTSSRVVCIVVAVLMHYFTLTSMAWMGVEAASMYLKLVRVFNSDVEHFMIKASVVAWGLPSLVIDVILAVDYTVYDNEYSCFLKPGAAFFFGQLLIIGLVFLFNAVIFVLISRKFLCRDKTLQSTANTSKKKQGTAMKRLQNIAAVSLLLGMTWVFGLLSIFEASSFTFQVIFAVCNSLQGLFIFLLFVVRQEKIRASVMARLRGRNRVDANATTASSVSKFISNAEEDKEPGSNELTDDIILSEKYEKDNGAPNSAETAETTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHU3</accession>
    <name>A0A913ZHU3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051352.1">
        <property type="nucleotide sequence ID" value="XM_038195424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195424.1">
        <property type="protein sequence ID" value="XP_038051352.1"/>
        <property type="gene ID" value="LOC119724393"/>
    </dbReference>
    <dbReference type="GeneID" id="119724393"/>
    <dbReference type="OMA" id="FPICVVM"/>
    <dbReference type="OrthoDB" id="10061042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="39596" checksum="8771017BDB412EF7" modified="2023-02-22" version="1">MEEKEPAVVRRKTKGSDSVENNPADGQTETVPNKEENHKTSSKEYTESVSQWLMQYRTHQWMHYCSQHALMMAPYFFGSPFPPVNTPNGSPSSPFGVPPPASGPADHAPFFQQQQNGQQQPQVQVPGQFPFTFPQPPMIDTPVQPPQQQTAQPHIPQLTVSEFTLPSLYRRIFAEIIDFILLFVMKFGVTLFVIEYMGIVDPSSFMMRFLIEEIDEDSTFEDLQQMLLFALIYRVVVCTYETFFLRHGLGTRVGGATPGKYCMGLRVVSCDRVQTLGGNRVLVTSPEDLTYLQAFLRAVIKNFSMAFFFPACITVFFNPHFRAAYDILTRSVVVSVPNWAERLRPQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI89</accession>
    <name>A0A913ZI89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050760.1">
        <property type="nucleotide sequence ID" value="XM_038194832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194832.1">
        <property type="protein sequence ID" value="XP_038050760.1"/>
        <property type="gene ID" value="LOC119723925"/>
    </dbReference>
    <dbReference type="GeneID" id="119723925"/>
    <dbReference type="CTD" id="55425"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="243"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="391" mass="43574" checksum="F88D12A0FFC919F9" modified="2023-02-22" version="1">MAESDSSDCDIGPALPPHMRAAGRNDRATGPKQSREDPDDAIGPALPPHLRRSQNSEDPTSTTEDTIGPALPPAPAMKKCDGRTSESSGQLGPALPPQLIKTKDSKTRDEEPTKDTRNREASDEEDAAYGPALPPSFTSSKDPSDDQRTGALGPALPPGFRKVTTEDESDDSSDSEGESSDEELIGPMLPTAGDSLRQRTVAEELEARAAAMKDKLTRKVEEVAPSRDSWMTELPEFSKNFGLGTRTFRKNARPDEKDRSGWTDTPADRARKQQERMEKAAAEMRAPSSSKEKKKKERREEKQLSERDKRLAKEVAQHNQAARPESLMDMHSKSRKRKLKEEGMTEQERRPFDRETDLQVNRFDEARRKQLLKKSAHLGDKFSHGSEKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJZ9</accession>
    <name>A0A913ZJZ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052113.1">
        <property type="nucleotide sequence ID" value="XM_038196185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196185.1">
        <property type="protein sequence ID" value="XP_038052113.1"/>
        <property type="gene ID" value="LOC119724888"/>
    </dbReference>
    <dbReference type="GeneID" id="119724888"/>
    <dbReference type="OMA" id="ANEESHF"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644">
        <property type="entry name" value="AGAP008221-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1131"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1458" mass="162399" checksum="6443111469550E93" modified="2023-02-22" version="1">MDAGKMDRVTPDEFNSGKLQVKALVAALNTDEKEKPQEDSVDRIPDSNLQLGHQKGCCKIASLVLTGCDQHVNHDPENQQKERSLDLVESPDRQLQGNNSNTNTVEVINQETFYAKSKQTIQEAGTNIFKGDFLSTNASSELKIESSAHLCLAQQNLPPDLFDGVLDINTVASLLPKDRTSTEESAIEHILALESDQSRHRHHSVPNEDCNGFTSEQDSGIFDLSLVQQDDFETFDNREASREWPVRNITPEQRRKHLQRSVSDSSKLLGHRPKEGCHCQKVKRNLRIPSCFINNPPLFLGSEVCENTSGQNIKLPVNPPATNTETKQAVENIAESCSQVITDSERGETRSTNFLESGTQNLTPPNASECQERCSLVTSSDSEPESNKSLEDYLEDITMGKKTQSLSKGRQPHVVYSKEEFSEEYASPKRSKSWDKKKHGKKGSEKKDKQKPKDRKRVLSDPSQGMDLKVVISPPLTVSQEESLRNKRHTIGGFLMTMPTQEAGTDTSELLADSEMLTAHQESRQFAATPNVSNNNQEQHKSKKRLAQSRAGGISPEVIPTASRHPLRKQQGLSSPEVIADTLSKASSSSDVISDGPPPPKPKRLSLTNQLQKQNDKSLDVSIHQDGSQLPYPKKDNVYERKTEIAVERQVLLKQATKSNPLDQQSQLHDSAVSSHKQANRSDAPGPFSVVTRYGDDGEEELILGALPLQEKQQEVPPESKPSVPNVARKPEKPIPAKRKIRHYACIEPVGKPVQAIKTEEHKEESTPKKSPTEPPKEEQSKPNLDQIPSSDEAAPVSKSSTIDQEVKPPVQQTPPVVITGPPPDTSLKVRDVTPDSPSTSLPPKSPSSPETQEDPPQSQTNENTPLSVDINRSRLTSSSDTASTASIPPQSPPDLDYQELLAQATPSEHSLPSSSEPSINIDFAKLDPAMEQKMVTVSVGMMPEVQKAEVTVINEDCQEVNSTDEVERQEAAEVQQQPMSPDTKEESATESPPTSEVVTSQPDIPSISSKEEDEVDNEEDEDSGVYDASYRHSDWIYVGNNQELQMMTKQVEMQAGAAKSLQTVAEVNNSQAADEVPQFDRADEARESVTTTSSENEFRMQHQSLAYRRVHRKTSAIDYQRLSLIARERKVTIKKVNNMFGFRIQYSRPVVVTDVDKGGAAEQAGLRVGDMVLRVNGHDVRQAPHSQVVRLAMSGPDPLDLVVGTNVCNTLNLYAEKPVMCGYLHKLGGAGMIRTWKKRWFVLKYDNCLYYYKTEDDVEPLGAIVLCNYTVMKARDVGKSYAFKLTKCKARTYYFYTATEEEMSRWAKNITEAAKPQNTSDIWLDISTHNVGLPALSIRNPDCHGFLNKLGAIRKTWKKRFCVLKDACLYYYKDIDAQHALGVAHFHGYSIQETEIGSKKYGLVLKHPSQELRVFYFLADHETDRKRWVAAFAMSIGRWIQTNNGEESDEESAEMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKI1</accession>
    <name>A0A913ZKI1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052303.1">
        <property type="nucleotide sequence ID" value="XM_038196375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196375.1">
        <property type="protein sequence ID" value="XP_038052303.1"/>
        <property type="gene ID" value="LOC119725010"/>
    </dbReference>
    <dbReference type="GeneID" id="119725010"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1176"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1303"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1379"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1426"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1462"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="192"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="314"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="479"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="601"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="764"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1192"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1530" mass="170212" checksum="AAC33873CF03FCF0" modified="2023-02-22" version="1">MKFTRAFLLPTFEFEVKITQESSEGSCGQDEFACQDVSSGLICLARDDTCDGDGFTLCPDGSDESNCLACGKSNITLSNSRQTSETLTLPQYLNNYPNDARCIWFITVDEGSKIAFRFSVFKIVRTYITLTIGNGHESSDSDSIIVRFRGFLKSLAVVSNNHTAWMELTSVFVLTTIEFEVKITQESSEVLCGKSNITLSNSTQTSETLTSPYYPNNFPINAWCIWYITVDEGSKIAFRFSVFNTIRTYDTLTIGNGHESSDSDSVIGLLSGSLTSLAVISNTHTAWMKFTSDSSVTKIGFEVKITQESYEVLCGKSNITLSNSTQTSETLTSPYYPNNYPINARCIWFITVDEGSTIAFRFSVFNTNRKYDTLTIGNGHESSDCDSVIGRFSSFLKSLAVVSNNHTAWMEFTSNFSRTAIGFKVKITQESSEGSCGQDEFACQNVSSGLICLARDDTCDGDGFTLCPDGSDESNCLPCGKSNITLGNSTQTSEILTSPYYPNNYPTNARCIWFITVDEGSTITFRFFLFNTERTWDKLTIGNGHESSDGDSVIGLFSGSLMSLTAVSNNQTAWMEFTSNSLVTKIGFVVKITQESYEVLCGKSNITLSNSAQTSETLTSPYFPNNYPINARCIWFITVDEGSTIAFRFSIFYTEKTHDTLTIGNGHESPDSDSVIGLFSGPLMSLTAVSNNHTAWMEFTSNSLVTKIGFVVEITQESYEVSCRQNEFKCKDNSSGLICLTHDVTCDRFALCPDGSDEFYCDDCGPRNIGVDIDLINLNSPRYPDGYPNNHNCSWLIKGQSKQLVTMRIKDFEMEETYDYLEVVFLRNGEDPKERFRLTGADVSRRTVTWRHDDGVLMLEMKTDLTIARRGFSILINHIKEEDLEALCQPDEFHCGKGFCVTNSSRCNGYLDCIEEEDELNCDDIFCPGSYKCNNLNTSSMSSSFTGNFTQAQCIPLAQVCDGEENCPESDDEIQCDVKRCPAGCKCSYKGSDLVVHCNNGWDSSTLAGLALITHTLQLSGVNISKLDQGVFKAISHLKVLSLKNNRITEIQERTFDGLENLLWLDLSNTLITELQGSAMEELSSLRGITIFDVPLTRIKTNAFDGLSQVKTLIIVRNIEGLPPLVVEDGAFQGLDNVAELYVDDHRLCCFFPSSECKTLEPQPPLFMCSELMPKMVLKVFMWILGVSPLIGNIYVMVWRYRERSKGRESRIVQSFLVFNLAVSDALMGLYMLIIASADVYFGERYFEVSMEWRTSPMCKIAGFISIIGSEASVFFLTLISIDRYLAIVHPLKKYNLCPESSRIAALCVWIGTVIVGLVPTILASDSSSDVYGLSDVCIGLPLMTKVTEYETVDQQIDAGGVANITVGIPYPVDYRASWFFSIALFLGVNLLCFTVILICYIAIFRRVRASSKKVNSSSRDDEQRLAIKMAAIILTDFVCWVPVIIMGILSQARVVEIPTEAYAWIVVFILPINSSLNPYLYTIADLCYQQQKAASVRRKYELAMKNARSNSENRSNVPVVKTVTSETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKL5</accession>
    <name>A0A913ZKL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052333.1">
        <property type="nucleotide sequence ID" value="XM_038196405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196405.1">
        <property type="protein sequence ID" value="XP_038052333.1"/>
        <property type="gene ID" value="LOC119725039"/>
    </dbReference>
    <dbReference type="GeneID" id="119725039"/>
    <dbReference type="OMA" id="DICHIPV"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF14">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037022244" description="Sulfurtransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="115"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="24445" checksum="BA3FAB2607E6BFF6" modified="2023-02-22" version="1">MAMAAILSRAVLATTRCAGVRAASVAPQYNSPGCLRPPITSGITVYICSFLGSGSNDLTQQHQWIHRSLYTQYPTENPSLIPGSVASIRRSLSTDSSQLEDADNVYFDGLLKRVESGDMQMIDVRDASEIEEFGTIIKDICHIPVLDVEAALQLPDGEFRSKYGRGKPQKSDDNIVFTCKKGIRSLKARDTARSLGYSKARHYPGGWMEWGRKNNLPYPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLY0</accession>
    <name>A0A913ZLY0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052772.1">
        <property type="nucleotide sequence ID" value="XM_038196844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLY0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196844.1">
        <property type="protein sequence ID" value="XP_038052772.1"/>
        <property type="gene ID" value="LOC119725438"/>
    </dbReference>
    <dbReference type="GeneID" id="119725438"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38737" checksum="689800FB75368E11" modified="2023-02-22" version="1">MVGAAFVNSFVIYGQIKALGVLLIPMTNDLDSDLWLVGWIAILHVMALNCFGIGAAFSFFISYAVMASYFKEKYPLAAGIATMGFPVGVMIYGPVTQVLLDTYGWRGTMLLLGSVSFHLVAFALLVRRDPSSSSPDSQQYQEVSVSEEEDADSKENPTLCSNHTPCTSDSALRKSRLWECCQRFTNAFDLALLKDKRFVFLASARFTGALAYSAWVVYVVPHGQFQGLTETQASFLPTAFGFGNVIGKLVAPILQEVGVKPSMTFWACFGASVVCPSFLLDAFIRPFIGQLAVMGLVGVGYAMMYQAIDVMLRFLSTDDRLVSILCWQGVFIGISSALGGLVAGVMLFPYYFPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP20</accession>
    <name>A0A913ZP20_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053538.1">
        <property type="nucleotide sequence ID" value="XM_038197610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197610.1">
        <property type="protein sequence ID" value="XP_038053538.1"/>
        <property type="gene ID" value="LOC119725989"/>
    </dbReference>
    <dbReference type="GeneID" id="119725989"/>
    <dbReference type="OMA" id="PIHNKHY"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="117"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="326" mass="37470" checksum="F536C9DD9D2D01BC" modified="2023-02-22" version="1">MTFTTTVPFHHNPLSSVFAQKYAPRYSQNDSELFSYLAAISKQKWVYNSSNAKEFRVDLRAALGKEGRFENFIATRQNTRLDQNISFYLRGSMLMSKTLWRSLPRDTIYKRRRHRTCSVVGSSGVLNGSRCGNLIDKANFVLRFNLAYVKGYEADVGIKTHFTTLNPSLVYKRFNRLRTKQNYADFEEVLKQFKGSQLWLPAFASTLHHRTLLRVASAARYSKLVTPILGHPDHYTTVAKLWKKTLNVTGWTTTGLHVFTSIFDLCDRIDVFGFWPFAESLEGKTLPYHYHDGRRGSSAHSFTKEFKAILHLHELGIINLHLGSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPF5</accession>
    <name>A0A913ZPF5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053612.1">
        <property type="nucleotide sequence ID" value="XM_038197684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197684.1">
        <property type="protein sequence ID" value="XP_038053612.1"/>
        <property type="gene ID" value="LOC119726066"/>
    </dbReference>
    <dbReference type="GeneID" id="119726066"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="207" mass="22161" checksum="B1CAA9D0DE802B9C" modified="2023-02-22" version="1">MSRGFTRFENDEVDTDDVPPAPADGPPGTQISLDDLPNDQDLHPQPDPGIVHPTSTGVANLALTPLPSADELGQTPPHPSDGPPPGQENAPPPPYSILSPGGTSVISSQPLPGPVDMHVTSVPCTDDSPDISNYSWWEYLLATTCCIPCGIIHLIVHFCVVRKREEAGDYEGATRALKTAYIMYYSAALIVLIIASVLSVVYIFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR26</accession>
    <name>A0A913ZR26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053546.1">
        <property type="nucleotide sequence ID" value="XM_038197618.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197618.1">
        <property type="protein sequence ID" value="XP_038053546.1"/>
        <property type="gene ID" value="LOC119725997"/>
    </dbReference>
    <dbReference type="GeneID" id="119725997"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1854" mass="212295" checksum="BB4822265B636F7E" modified="2023-02-22" version="1">MDAKDSVSQISPMSNRTSSTVHVKAAAKRAELLCRQRLLTKKQELESRHLAVQQARQQEEFRLQREKENFDLQVEIEVSEASISAIEQYEDEFDQKIRFKLPDEIPHPAACASSVLGDRIEAGASERVSSNEEPNKIENPWSIPQDFQGKVDEVENRMPELTPQVNIGQLHKDCAQLDHHDVPEPTTAQRYQPHLQPISDIGELTQPLIKQQVRAALPAQQIETFNGDTLKYTRFVKSFEFGVEDKTTDVRDRLNYLCQYTSGEPNTLVSSCLHYHDAEEGYSKAKELLAKRYGNSHKIAQAVLNKANNWPDIRAEDATGLNKFSIFLSECKNMTKSVSALSELNHTQSIQMLVEKLPYRLRSMWRNKVYEVEEEKKRCIVLDDLVSFVDRHSQILSNPTFGRLRETPHLGKNNIGEKNKRVQVKKEAFGTAVNSHAEKARQKKSCQFCGGNSHHATLECMKFAQLSWKDKSSFCFKHGLCFGCLGGGHTKSSCKQRELSKCSKCPGNHPTVLHNDEKITKTSHPAQNSQTQVTTGCAGVLGAGANLHASGSPRMAIVPVLVKASSSHECIATYAFLDNGCGAVFADSEICRALKVRTRKRSIILKTLNSEEVVDSIVIDRLQLGGMIEENSFIDLPDVYVKNDIPVSPEDMVTKDDLQGWTHLSHIQLPQLCSPAIPRVTLIIGMNVPAATTPIEVIRGNSGDPYGVKTPVGWVIYGVPGRPKSQLDANYINVLDGLTNLEDQYKHYMNLDFNERLGESQDESALSKEDMRFLDIVKETTEFQGGHYQMALPLQRPTVRMPDNRSLAEKRAVQLKRKFDKNQEFKEKYVQAMEDTIGKGYVEKVPDSQKFRSDGKVWFIPHHGVYQVQKQKMRVVYDCAAEYGGVSLNRQLLQGPDMTNGLTGVLMRFRQEPVAVKADIEAMFYQVRVRSEDRDLLRFLWWPGGDLSRELEETATDNEQRYRSEVTNAVRKNFYVDDFCKSVPDKEEAKVISREVTDLLAEGGFRLTKWVSNQREVLRSIPREEWSKEVKGLQIDQDVLPPDKTLGVLWCMESDTFGFEINVKDREPTRRGILSIVSSVYDPLGMVSAAIMPAKLLLQDLCRLKLNWDEKIPQEHLHKWNLWLMDLPKLECISVDRCFKPEGFQDPVSVQIHHFADASEKGYGVVSYLRLQNRYGDVHCSFVTSKSRVTPLKQQSIPRLELTAATVAVRVHNSIVRELEIPVDQTFFWTDSMTVIKYICNETTRFKSFVANRLTVIRDSSHPCQCKYVRSEQNPADDCSRGLPIDKFIANRRWFRGPEFLWHAEADWPSTCVTEEPEVDRDPEVKRVMAAVPIENLLSRSNAVKKLIEYYSDWNRLRRAAAWWLRLKRILRKRSKEEFKHDAVNNLTVEEIEEAEVSILRWVQHEAFPHQIKRLQEMNDGPQDLTRESPKQQKVDKLLDQLDPVMHKSLMRVGGRLQAAQLPEEAKHQIILPQRCHVTDLIMQHTHQKIHHQGRNHVLAELRRRYWILKAGVVLKSVLKRCVICKKVQAKLGQQKMANLPANRLLSEKPAFTSTGIDYFGPFNIKQGRNIKKRYEVVFTCSTSRAVHIEIAESLDTSSCINAVRRFIARRGNIKELISDNGTNLVGAHAELKKAMSEWNHETLEKFTTDRGITWKFNPPAASHFGGIWERQIRTIRKILQAMLNEQHMRVCRDEEQLRTLMCEVEYTINSRPLTHASDDPKDLNAITPNDLLLLRPSSLYVAPPGVFSEKDQYAKRRWRQMQYLADLFWKRWSREYLMDLQQRQKWLYPQRNLHPGDVVLVADNQAPRSSWPLGIVEKTYPDKNGLIRSAEGCMNRHHLLELHLCALCIQCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR71</accession>
    <name>A0A913ZR71_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053645.1">
        <property type="nucleotide sequence ID" value="XM_038197717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197717.1">
        <property type="protein sequence ID" value="XP_038053645.1"/>
        <property type="gene ID" value="LOC119726105"/>
    </dbReference>
    <dbReference type="GeneID" id="119726105"/>
    <dbReference type="OMA" id="HISCVAR"/>
    <dbReference type="OrthoDB" id="6112405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="635" mass="71102" checksum="0B49D7C962A6FF7B" modified="2023-02-22" version="1">MAEAAAKSVLGTISRGHLECPICCCRFTDPKLLDCLHSCCLNCLDELISRQQPKAGEITCPFCRRVTAVPDTGLQGLPNCFFLSSLVDEFNKQERLLGDAPADTRSCEECDEGLEAVSRCLDCDGNICQKCLDVHRKLKSTKKHRIVNFDQSRSQVPLADLRKKDWLQCHKHTNQELCFYCETCETLACAKCAALDHRTAEHEYREVPDAIRSYRQDVSESLRKFEQSREEFKVADDSLQHARNRLRIMVARACKDITAKEREEIAKIRNKSRLLRDEVKHIGKERDRKFEEVQKNNRDKVERAEQIVATVNDLMQQADDFELLDLKPKVMHNLEFKEELKLEQAQHELSFIGIKCQDVVANTSLGEVLLEEKWQLKEVLDEDSGDGQYKSAEGVACLSNDDLAITDTGKQQLKIVNSAGGKTPVGWDILNDPCGVVVSGDDVLLVTDKMHVKVFDSSLEFIRQFTPSHNDTGQDSESCLTGIAVDEKNRIAVADSGRKLISLHMLDGSLMKTIPHEMVGYGLAVGIKERLIFTNYSNERLICITYTGEGVFSVSTSCVKQHGRPSGVCCDDAGDIYVSVDSEEFEGGEVHHYTPEGVFIGRVARGLHSPCGLTFTPSGDLVVADEVSVKIFQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRL6</accession>
    <name>A0A913ZRL6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">THO complex subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054292.1">
        <property type="nucleotide sequence ID" value="XM_038198364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198364.1">
        <property type="protein sequence ID" value="XP_038054292.1"/>
        <property type="gene ID" value="LOC119726617"/>
    </dbReference>
    <dbReference type="GeneID" id="119726617"/>
    <dbReference type="OMA" id="WANSKND"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24825" checksum="9AABAAEC0EFA2563" modified="2023-02-22" version="1">MRKMATVTDDEVIRRRLLIEGESGGDDRRINTLLRMFIKWCNSDTSDEESLATYQKMQSILAQVEFAMEKTQLIHDMNTKEMTNYEELYSEIEQSIKEAYAKISACKLQVQDAKRVRKNRQEYDALAKVIKNQPDRKESMKKLEDLDRELSNLKHSKQTLEQKLEDRRKQFHVLISSIQELQRILEEDDKGKEVPMETTLDSSMDTSLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTM7</accession>
    <name>A0A913ZTM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inter-alpha-trypsin inhibitor heavy chain H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITIH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054555.1">
        <property type="nucleotide sequence ID" value="XM_038198627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198627.1">
        <property type="protein sequence ID" value="XP_038054555.1"/>
        <property type="gene ID" value="LOC119726777"/>
    </dbReference>
    <dbReference type="GeneID" id="119726777"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030212">
        <property type="term" value="P:hyaluronan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000013">
        <property type="entry name" value="inter-alpha-trypsin inhibitor heavy chain H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010600">
        <property type="entry name" value="ITI_HC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06668">
        <property type="entry name" value="ITI_HC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111001" description="Inter-alpha-trypsin inhibitor heavy chain H4" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="11">
        <location>
            <begin position="73"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="335"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112386" checksum="4DB2B7B590D5480D" modified="2023-02-22" version="1">MMRDLLLLMILAATFWCNDAAPHRAIKTPSFIASLDKASQRAKRESPIMPVIVDPWKVFFTTTTSTKTTQTTVNPDVIVPDPDPKPLKIRGLRVLSLVTARFTKTVVESFVVNPAEMSQEINFYMELPKEAFISGFLIETDGVVYNSRVDEKEAAQQAYDQAKSQGQTTGQVKQTSEEKNDFTISINVEAGSELRFNLTYEELLKRKDGFFENVISITPGQTVDHLIVDVHITEPQGIKEESVDFFVKKRLTDGSTEVQRPEWARLKGQHSDRVSVQFHPTPEEQEALSTNGNFGKFVVRYDVVHGQNAGNIEIVNGYFVHHFSPEGGFLPIQKSVVFVLDTSGSMSGTKIRQTKEAMDTILSDLREKDEFGIITFSSSTRAWRSRMVPANKANIESAKDEIQGLQARGGTNLHGGIVDAIEMLEDAQNNDLSTVGKFYLIIVLTDGMPTAGELTRPDEIKRDIRRRLDGRFSLFCLGFGDNLDYTFLEQLSLQNKGLARKIYEDSDAGLQLVGFFDEVATPLLVNIRMKYDENMVISNSVSDTVFPTYFEGTELVVAGQLAANYSLPERVICTVLVESGGIEIELELEANVQEESVLSPHTVDDFAQRLWAFLTIKELLQKRIAEERDSEKAELTQRALELSLKYHFVTPLTSLVVVKPDEDDALIGEPQPRMEDDAFEDMMMHKPVSRKQRPPSQPNRQRSGSVGPIGPIGPIAPQGSSILASPMHPPPSGPVGLNYGRVAGIMPAPTSLHKAPTKAPTTTTTVATTTLATTAPTPTTPMGPPRKYRATFVMPMEGNGALCFNLRARHGQLYKLIDDQVAGLTVSGRMASAYLTNHLPNGNETLPLVLDRVTFQDGSLEVSPDGISIGPTVTLPWTGGWTVTVQGLKVSVRAGQQLTVRVGSDITLVIQKRVGNSLEHKRDFLGFEIKNGQGLSDQVDGIIGQFERREIRLDADSVSGEGDRRRGSLTVAGQRLDVRISERMDLREDRARECWWHAESNNILENPLRHYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU55</accession>
    <name>A0A913ZU55_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054754.1">
        <property type="nucleotide sequence ID" value="XM_038198826.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054755.1">
        <property type="nucleotide sequence ID" value="XM_038198827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU55"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198826.1">
        <property type="protein sequence ID" value="XP_038054754.1"/>
        <property type="gene ID" value="LOC119726974"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198827.1">
        <property type="protein sequence ID" value="XP_038054755.1"/>
        <property type="gene ID" value="LOC119726974"/>
    </dbReference>
    <dbReference type="GeneID" id="119726974"/>
    <dbReference type="OMA" id="SSRIYGC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="116" mass="13277" checksum="4DEA46F16678EFFA" modified="2023-02-22" version="1">MVKTFQAYLPSCHRRYSCIHCRAHLANHDDLISKSFQGSQGRAYLFNSVVNIACGPAEERVLLTGLHAVSDIFCECCKTTLGWKYEHAFENSQKYKEGKYIIELAHMIKDNGWDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVR7</accession>
    <name>A0A913ZVR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055632.1">
        <property type="nucleotide sequence ID" value="XM_038199704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199704.1">
        <property type="protein sequence ID" value="XP_038055632.1"/>
        <property type="gene ID" value="LOC119727692"/>
    </dbReference>
    <dbReference type="GeneID" id="119727692"/>
    <dbReference type="OMA" id="PCCAVEI"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038156042" description="Gamma-aminobutyric acid receptor subunit beta" evidence="20">
        <location>
            <begin position="27"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="44"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="254"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="502" mass="56858" checksum="D1DD28974ADFE39F" modified="2023-02-22" version="1">MARFLFTLAFVICPCVFSLFASVIQADESANELTASRRAENVSALLDGLLEGYDKRLRPNFGGPSVPVNISMYVYSVGPVTESQMQYTIDMYFRQQWIDERLRFTGDVTVLSLNSEMVDRLWVPDTYFVNEKSAKFHTILYKNTLIRIEQNGNILYSTRLTVTASCYMDLAFFPMDKQRCSLTMESYAYSDNQVHYYWIPSGPIYVDEAVTLPQFQFLGSSQRANTAQYYVGNYSQLIADFYLGREISYYLINVYLPATLIVIVSWVSFWIPRSSTPARTALGITTVLTMTTLIGNAGSSLPKLSYIKAIDLYLEMCYFFVFAALLEFALVSYYEKPSFKEARQRMKERAENGNSPASKSSGSPSSVYSVDKRRDEIEITFVNENALKEANLSRAEMINRGGARRCSYIRAAERGSPPAKPSSKSPSTPWRDQHDMTKCEEMCGPNCADFGEVGIDPGKVDMNSRRFFPLVFVLLKIIYWAYYVTVTSGGLEDLIAEVEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWE3</accession>
    <name>A0A913ZWE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055973.1">
        <property type="nucleotide sequence ID" value="XM_038200045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200045.1">
        <property type="protein sequence ID" value="XP_038055973.1"/>
        <property type="gene ID" value="LOC119727963"/>
    </dbReference>
    <dbReference type="GeneID" id="119727963"/>
    <dbReference type="OMA" id="PNNDYAN"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036676569" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="178" mass="19940" checksum="451F711AFC7AF1CE" modified="2023-02-22" version="1">MMLPKRLIVGLISLRLMIRCTGGNERCGASIRGACPPAWSQWGDTCYKQLSENLPWAEAKQECIKMGSVLVMPQSQEETEFLLKNLIDYFWINCSDQQVEGAWVCQDGTTDVEYRNWRDGEPSNGWGKEDCAAAGESGWNDVPCDDLAPVICQRPAPQLHFKVSTKTLTAHQEISTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX55</accession>
    <name>A0A913ZX55_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="RefSeq" id="XP_038056233.1">
        <property type="nucleotide sequence ID" value="XM_038200305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX55"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200305.1">
        <property type="protein sequence ID" value="XP_038056233.1"/>
        <property type="gene ID" value="LOC119728183"/>
    </dbReference>
    <dbReference type="GeneID" id="119728183"/>
    <dbReference type="OMA" id="WLEVRDM"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07855">
        <property type="entry name" value="STKc_ERK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="613"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="742"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="824"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="919"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="667"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="838"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124156" checksum="ADABA7197334A997" modified="2023-02-22" version="1">MQHAAARNLRAFKTKCLDVSFDLDNSEYRAIQNIGTGAYGVVCSATHKKTSEKVAIKKIPNAFEELTTAKRTYRELKIMRHFRHENVIGIREILMPKEPLNDFRDVYVVLDLMESDLHHIIHSQQSVSMEHIRYFLYQILRGLKYIHSANVVHRDLKPSNLLVNENCELKIGDFGMARGLSGNADSKRKMFMTVYVATRWYRAPELLFSNDDYSYAVDMWSVGCIFAEMLGRKQIFPGKNPMHQLTLIIEVLGMPPDSLLRSTNSDQIFNFFHRNFGGKQSTNLRDKYPNLDEDGKDLLSKMLVFNPSDRISVKDALSHPFLAKYHDPDDEPECFPTFDFSFEQDELTKQQIRQNVGKMILKYQRTKLFAGKKFPGSVSVVKPSTAATATSAAFQETKSAIMQLAAASVLPANTLPVANPPDTKQSSDVKCPPKEGIFKVPSIPAEEKKFLTPEAKPNKMVSEAEETLSVMAVSTLSVSNDVHMKSATRSAQNSAIGNTDGLVQGMSTLKTLTASSSNTISEDVEMKSAHGEQKEPLNGSSIGPSVSESQDVDMKSARRQGAETNSVTISSQVKDSLNSSKQPLPSVVVEGTGQKTISEDTKELIKAALRQSVLKNKMRKESEAEKGGGKIPVTAVARQREREQKRRQKLRRSIERQKKGKAKGKKNTKEVQEDDKHQMLTDEDRSMLERWNKMLKKKDQEEPSESDKAGDDSSALGSEHSKVIKEESLLFHKRVESDVGVSAAVAEPSQNTRGSSSRSSVTELGESVSSITNTAQGGQKVGEKIATSGVVETISVPTQQQISSLDSTASTNMFPFSVASKAQKNSYSSATKTSPSSLNNFGTNNAQLYFSQPSSQPMNTNPNHSFYAQSDQKSSSVITSRQTGDQQMSTATSSANQPPASTTDTATAQLLSRYPTATSLSVGFQPGKSDGSSGFQQYRSRHYSDRETPSPPHNIQQSPPAYEDSMKARFTPYTSPTGNPQSYPYKHSSQYLSLSKQSPVRQDGLPTHSRPSPTPPELAQVIRQLSKSAMEDSLPPILQVTPKGDGAGYGLSMDLEDWLEGSLGSPPAACKLDSGPLSASLLSDWLEVRDMNMDDMIAVQLELGLTSPFNLSDIPGLVESPKNKDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY93</accession>
    <name>A0A913ZY93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056613.1">
        <property type="nucleotide sequence ID" value="XM_038200685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200685.1">
        <property type="protein sequence ID" value="XP_038056613.1"/>
        <property type="gene ID" value="LOC119728443"/>
    </dbReference>
    <dbReference type="GeneID" id="119728443"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="292" mass="33293" checksum="D90C063AF3BE7490" modified="2023-02-22" version="1">MKFSCQKADSSQDPLQKWSSARTWNIDVILQHTFEELLPGVNYVISLHQHRHVQHAVRTQDATTYYPLSVDVSGTSATISGLNQLHINAVQVCPCLMLPRCKNWINISPGQNELVISDIPPGIEYFVKAGTVDSEQLPSRQKFRCKVEGKLHVDVQEITQDHRTSNCVTFEEALKSVDLKKSLQVEFDSTRDNPHLPEMVAQALGLDGDDRRIITGASSEHVEKLDQILTSRDNDTQVHDLIERLLLMEQRSDTEMRPRKEAEAFLIKVVGHTWTRFHCLECIRLLHQEHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYC8</accession>
    <name>A0A913ZYC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056071.1">
        <property type="nucleotide sequence ID" value="XM_038200143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200143.1">
        <property type="protein sequence ID" value="XP_038056071.1"/>
        <property type="gene ID" value="LOC119728068"/>
    </dbReference>
    <dbReference type="GeneID" id="119728068"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33154" checksum="57322AAFA0458354" modified="2023-02-22" version="1">MGCPIGMMAYGPVTQVLLGTYGWRGTTLLVGGISFHLVACAMLVRLDPSSSSPDNEQYQEVSVNDGDENQSSGEGRDCPDDKTDNSKKSCCDPDHRQNRTGMCCRNIVKAIDMALLTDVRFVLLICARCTASFTYSAWVVYMVSHGQFQGLSEIQASFLPTAFGVGNVIAKLVLPLLQQIGIKPSMTFWACFGAGIVGVSFLLDAFIRPFIGQLALTGFVGVGYGVFFQALDVMVRFLVSDDRFVSVLGWQGMFTGIAGTLGGLISGWIYEWTGGFSIVLCVFAGVTLLSIPFFVTEALYAKRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYS4</accession>
    <name>A0A913ZYS4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056629.1">
        <property type="nucleotide sequence ID" value="XM_038200701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYS4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200701.1">
        <property type="protein sequence ID" value="XP_038056629.1"/>
        <property type="gene ID" value="LOC119728452"/>
    </dbReference>
    <dbReference type="GeneID" id="119728452"/>
    <dbReference type="OMA" id="PRANEWE"/>
    <dbReference type="OrthoDB" id="10651396at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="26687" checksum="C0882F622F4259C7" modified="2023-02-22" version="1">MGCSGSTQTKQQSPKHNNSAPAPQQKAPAAEEPIVPQKQTQEGVNSTTLPPTDNKHIEDQTTVSPKEPEPEKEEEKKDEEKPTEESKTEPADTRTEEPAKEQEPAAQEEVKEEAAEEKTPEQQEAEPAEVKATTEVDGDSPPSETCAENGELIHETAVASEEPKESAPAETQDLEQSQTEQLTDTQATEEAHQDAAEGQEGVTEPTTEPTAEPTAEPTADPTTEPTTEPPTEEGGDAKTDQATEDAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYY0</accession>
    <name>A0A913ZYY0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038056838.1">
        <property type="nucleotide sequence ID" value="XM_038200910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYY0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200910.1">
        <property type="protein sequence ID" value="XP_038056838.1"/>
        <property type="gene ID" value="LOC119728609"/>
    </dbReference>
    <dbReference type="GeneID" id="119728609"/>
    <dbReference type="OMA" id="HKQKKDT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17958">
        <property type="entry name" value="DEADc_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="229"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="416"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="662" mass="74317" checksum="E6BD229D5A173950" modified="2023-02-22" version="1">MPSRGRGFRNQIPHVQSQEFSRTPTQQWNSSFETVSVGSNDVGKIIGRQGSKIRELQDDSGARIKVPRDQENDDGTVPVELRGTEEAIEKARQMIEELLRPSMSYKSRASLPSTAATAPNGEYKRPVINWKQAIANAANSEMEKWHDYPEVVKDFYIIAPSVENLTQSEAQEIRENLGVTIDDDCKDNPRPVPKPVRTFEEAFHHYPEIMREIRKQKFEKPSAIQSQGWPVALKGHDLIGIAQTGSGKTLAFLLPALIHTDLQPIPREQRGGPNVLVLSPTRELALQIKEEVSKYSYKGIKSVCVYGGGNRREQINIVQKGVEIIIATPGRLNDLIMNEIVDVKSVTFLILDEADRMLDMGFEPQIMKILLDVRPDRQTIMTSATWPDGVQRLARKYMKNPFHVNVGSLDLSACHSVTQLVEVIDEEYKKERLVDFISSLQEDEKLLVFVGRKSTADELSSEMSLLDISVQCIHGDREQYDREQALAEFKEGSVRILIATDVASRGLDIKDITHVLNYDSPSHIEEYVHRVGRTGRAGRTGTSLTLMTRRDWRWAADIMRIMAEANQEIPDDLLEMAERFERHKEKKEQERAMERENGGGGYRNRDGGRGYGGGGYRGGSRDRPREGGFGFGGGFGGGRGRGGRGGRRGGRSDDGFQGFFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZR5</accession>
    <name>A0A913ZZR5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Folate receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057123.1">
        <property type="nucleotide sequence ID" value="XM_038201195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZR5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201195.1">
        <property type="protein sequence ID" value="XP_038057123.1"/>
        <property type="gene ID" value="LOC119728799"/>
    </dbReference>
    <dbReference type="GeneID" id="119728799"/>
    <dbReference type="OMA" id="KDDFTCK"/>
    <dbReference type="OrthoDB" id="567542at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF14">
        <property type="entry name" value="FOLATE RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036689385" description="Folate receptor-like domain-containing protein" evidence="4">
        <location>
            <begin position="38"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="48"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="268" mass="30240" checksum="EAAD1FACA4607BE2" modified="2023-02-22" version="1">MLSFQGFFVPVSSVPHPKMVVYMQILLAACVLLLAQAERTTLEDYINTCMDGKYQKSKPGPEASLFNQCAPWKNRSCCTPEVTEDMHVSPTWHSFDWNHCPTALSEPCQRYLMQDLCFYECSPNVGPWLVPHNISIRNERFLGVPLCKTECHAWFNACRSDFTCKDNWAKGWDWSSGGNECPADTTCRTFSETFKTPENMCENIWGGSFKVVPDNEPCMLLFFNGDNNPNDKIARLKAEELLNAGSMATLHVWALLGVILATICLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A114</accession>
    <name>A0A914A114_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057342.1">
        <property type="nucleotide sequence ID" value="XM_038201414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057343.1">
        <property type="nucleotide sequence ID" value="XM_038201415.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057344.1">
        <property type="nucleotide sequence ID" value="XM_038201416.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057345.1">
        <property type="nucleotide sequence ID" value="XM_038201417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A114"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201414.1">
        <property type="protein sequence ID" value="XP_038057342.1"/>
        <property type="gene ID" value="LOC119728953"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201415.1">
        <property type="protein sequence ID" value="XP_038057343.1"/>
        <property type="gene ID" value="LOC119728953"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201416.1">
        <property type="protein sequence ID" value="XP_038057344.1"/>
        <property type="gene ID" value="LOC119728953"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201417.1">
        <property type="protein sequence ID" value="XP_038057345.1"/>
        <property type="gene ID" value="LOC119728953"/>
    </dbReference>
    <dbReference type="GeneID" id="119728953"/>
    <dbReference type="OMA" id="WESADYE"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009750">
        <property type="term" value="P:response to fructose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054017">
        <property type="entry name" value="GKRP_SIS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20741">
        <property type="entry name" value="GKRP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22198">
        <property type="entry name" value="GKRP_SIS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="68"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="317"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="655" mass="72349" checksum="7517F1EC8B326F3C" modified="2023-02-22" version="1">MTDSEIKIPITETSNPLTVDIDISSSYDLVGLLHQCDSEIFEGWDSYKSNNIFSDDLIFNLQRVSEKVVDILQKRNPACESVVFSGCGTSGRIGFLTSKSINNLLRNIDYKPCCEYIIAGDDKALLTSQESPEDSPQAGVKALQQICKKKKKVLYIGISCGLSAPFVAGQLLYCMEHLDIFTPVLVGFNPVEQARNNPIEGWNETFLSVVTKLSDVQSAGNGFIINPILGPEAITGSSRMKGGTATKLLLEIIMLNALRQLSSSMELGFVPDEDASHYLTADGAIRCNHLMHMYETVCKETYPQALSGGLHEVIDWAGTSLNAGRHVYYIGIDNIGVLGLVDASECPPTFGADVNDVRGFLFGGYTALENREGDLVIKSCPPVQEIIPIEDTMRRSYRDHQGSELEIGANYFVGTILHSLTPQDTVIFLTSSCSELNPAMKMMVQIVRGKCHQVVVFVCYRDANDTHEDIMPQFFSKIVRIRIPVTPYIRSFMEEEGKKPSWFDLLGVHAARRFAAELSCKLLLNAVSTGAHIQKGKVYKNLMVDLKLSNSKLFQRGIEIVKSLVMCSEDTARASVLRSLYGTNVVSEELKKMPVSEHTRIGSFKTKVIPTSLILASKGCLIHEAMEILLKFPVIRAALAQLWSVSNKTMAHFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1J5</accession>
    <name>A0A914A1J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057505.1">
        <property type="nucleotide sequence ID" value="XM_038201577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201577.1">
        <property type="protein sequence ID" value="XP_038057505.1"/>
        <property type="gene ID" value="LOC119729073"/>
    </dbReference>
    <dbReference type="GeneID" id="119729073"/>
    <dbReference type="OMA" id="FTENIMP"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="397"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117391" checksum="F94539DDC4F39CC7" modified="2023-02-22" version="1">MADVIGLLDDNCETVDSSDDRHPVRPSGFCYRYAKFLARFWYVVCLLVFVIVTACGVVTFKVYDLPDFSEPQKGFEARGTVIRSREFSLLHLRDNDLLVPRPSDADVNQGNFSKTSGSLKFRGPRTVDNKPLVPAGQSLSSIDAQSDTMVESSDLEPTSSTGFQFCTSIWNEGQYSVSTMVFEGVDGTNVLTMEAIKSVCEAEKRLVTFHPAYKSNCDCSFQGSGDCPTWSIGNYVALLANKTSCADIEQEDVRRATDLLALCAPIYGNTSKEDLLNPDLRKNLPDECIQHKYAAFAILHYLLPIAFSQNIDGQTALSSPICEVLFPITDSDALETIFKESVEKKSDTDGITRLKAVSFHIKFELFSDLLISDVMYMAISAGAIFLLIWVYTGSLLVAIVAFLNIVFSLVLADFCYTVVFVRPFFPFANIITVILMLGVGADDTFVYMDLWKKTKSEMGDRDIPGLVCETLRHASATMIVTSLTTAAALYATVFSHITALKCFAVFAGTGIIMNLVLTLTLLPAVIVMQHKLATWCCSLKICSQSCLSKGNGCLKTLSQRVKMVYEDLIPFLVLKLRYVWIVLFLLLMTGGAVVVFYYPRFRLPSSAEFQVFVSSHYFEQYDFVYREQFAFSQERFYDARGSVTWGVQALDNGNTWDPDDQGTLLLDDGFKFSSLEDQAWLLNFCQDLRKQAFYRSETQIDCFIEPFVDFMQNPRCKTFGIDLSPCCNQSESTYSPYLFETCMAKFADLSLFYQQVFFRKTDAKLAVIKIDFQTIFPSSYNFAKNDEFWVNVNTWVEDKLESAPKSLQRGWFVGTYGGLLFYDLQQSLATGTRNSMVITLAVASGILLLAMRNLLLTLLSMLTIASAVFVTVASLVLLGWELNIVEATIITLAVGLSVDFTIHYGVAYKLSPSDTRRQRARYSLTTMTPAITLAAFSTFLAGALVLPSTVLFYNRFAIFLMLVMSISWAHGTFFFQSLCMVIGPQGSCGDIPGLSKCGCSKQETGNVQPEQEQTSMHTYDNHVETNVLSDDVDFILGTDQALPPEQNYSMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1P6</accession>
    <name>A0A914A1P6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_038057281.1">
        <property type="nucleotide sequence ID" value="XM_038201353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1P6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201353.1">
        <property type="protein sequence ID" value="XP_038057281.1"/>
        <property type="gene ID" value="LOC119728916"/>
    </dbReference>
    <dbReference type="GeneID" id="119728916"/>
    <dbReference type="OMA" id="CKEVKKY"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000005">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000616">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase 2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="14">
        <location>
            <begin position="36"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="139"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="D-3-phosphoglycerate dehydrogenase ASB" evidence="16">
        <location>
            <begin position="357"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="558" mass="58859" checksum="182B4F71EF6A2DC0" modified="2023-02-22" version="1">MFWGSEISYSPTRRGHCIDRLHKISSNKMAFTLRNVLILDNVASCCAQILQDNGIKADSVAKLSKEELLARIPNYDGVIVRSATKITADVIDVAKNLKIIGRAGTGVDNIDVSAASRHGIIVMNTPAGNTLSAAEHTCAMMCAMSRYLPQGHMSLKEGRWDRKLFMGNELNGKTLAIVGLGKIGKEVATRMQSFGMTTIGYDPIIPASEAAEFNTEWMELEQLWSKADYITVHTPLIPQTRGLLGEKTFPLCKPGVRVINVARGGIIDEAALLKALESGQCGGAALDVFEQEPPTNSALIQHPKVVCTPHLGASTEEAQLRVAMEIAEQMVDAVNGKSLFGAINAHALSNALKPETKPLVSLGECLGAVATALCGQVTNQTQVQVITYGDCLKQAGSYLGAAVTVGLLRNSTSNGMNLVNAGVLAKEIGIQIATNHQDCSPVPLTSPCVSVVITVNGASHKISGSVMNGSPVLLEIDDAVFVSGVMLQGNMLVYNTQAGAAAFPAIASVLSASNQILSYGTTPPSNNGSWSAIQLASPLPSVDSLKQHASFAAQLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A405</accession>
    <name>A0A914A405_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 49</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058106.1">
        <property type="nucleotide sequence ID" value="XM_038202178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A405"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202178.1">
        <property type="protein sequence ID" value="XP_038058106.1"/>
        <property type="gene ID" value="LOC119729566"/>
    </dbReference>
    <dbReference type="GeneID" id="119729566"/>
    <dbReference type="OMA" id="HNDCISH"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134164" checksum="33492BE91798EB4B" modified="2023-02-22" version="1">MASPRESSPSNHGNQQVGTAVKTAIKAVAAMSVKSKDDDKKLEKKPSNTVASSGGVVTFGVKLESRLNIKDLQHLKKAFMAHGDGYNNRLSVEKDDFCNLLDRILTKGNPEEYADLFDKIDVTKEGKVDWDKIASHLLLEYVEKDDRVKSTQVPQWKDIKMLPSPHKDILQKMAFLKNSGRYIAISKEGGISTWDTRLHLMKSIRINNDAVKPRDMWVTTFVVLQNINKIALAFTSKEIVFYDLSSKLEFNCQYRVYGLEHTPLSMDHWSNPNNSNEAIIVMGDTGGNVNAFVFTSAIIALFDRPQQTAGEGQEQVVNVNFKHLLKDRFKYCRLVRHSGHQEWARQVKYALHLDCFISCSTTYENAMVLGWIEKARQKMKTSSFNIAQGVNAFDYHEVLNLIATAGVNHHVCLWNPYVVSKPVGLLRGHMAPVMHVQFNHRRGQLISFSKDKVLRIWDVQLQVCLQRIAGTFPKGPDLTTHMFFHEDRNRLFMAFNYQMALLEMKKEVKDRVLSHDKPITCAIYSSTFNQVVSACQGSTVNMWLLDTGQKVKQFINCHGNSEITTLALDHSETRLFTGSTDGTVKVWDFNGHCHHTLNAGMGEPADISQIVVLKRNFIVIGWNRYITVFRNQQLIQFHVQPSEWKGGQEHHDDILAAAFTAPHTLATASYDGEIIIWNSGSEVASRRLRQRYLKKVVKSRAGTRLGLKKEGTTVSGTASQPSVSPRQLESQSLTSALSRPPGAVADGTEGSKPQRPTSRGSDASEDEQNDYIITRLVFLDARKGQSASGGANLVSCGGNGWVRFWNTAKNSLLAEYIAHKHVSFVVMAVSEDNHMLVTGDTDGAIKVWNIQEYCVLHPETIITEPPPLVASWQPHADMINSLLVCERNDRTLIISASTDCSVQVWDIYGICIGTFGQEDHWKIEPYCPPPEPHPEDEAEHSDSGESYSGEALDATQDEMTEEMLEILMDPMTKVNTWEKTRLGKEYQEVRSKKRERKQPGTIPELPYLHWEKIPAGPAPMGNPAGGPFAQPPDKMVLPMWTQALTVPELDDVGTLRKPDFITHPHRYFRDREDMNNVKVLDKEPEEMFNLKNAYDERSLFPKYILEFEARMKTQHKEELEAMGGGQAAGKGRQNTNRRLKAWSMIASQSNSVAGMINGSQGGGAKGGGGGGGNGHHARPVRLSPLPEGKRPKPHESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4N5</accession>
    <name>A0A914A4N5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligosaccharyltransferase complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OSTC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058670.1">
        <property type="nucleotide sequence ID" value="XM_038202742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4N5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202742.1">
        <property type="protein sequence ID" value="XP_038058670.1"/>
        <property type="gene ID" value="LOC119729951"/>
    </dbReference>
    <dbReference type="GeneID" id="119729951"/>
    <dbReference type="CTD" id="58505"/>
    <dbReference type="OMA" id="CWIFMRM"/>
    <dbReference type="OrthoDB" id="10256333at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042416">
        <property type="entry name" value="OSTC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13160:SF4">
        <property type="entry name" value="OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="16778" checksum="D308EA13307C4B1A" modified="2023-02-22" version="1">MEQLYSIPFAVLECPNLKLKWPTWLHAPSAMTVYFVVLGSYFLVTGGLIYDVIVEPPSVGSTTDENGHQRPVAFMPYRVNGQYIMEGLASSFLFTVGGLGFVILDKSNAPMMPKLNRFLLLFVSFVCILVSFFMCRVFMRMKLPGYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A963</accession>
    <name>A0A914A963_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059976.1">
        <property type="nucleotide sequence ID" value="XM_038204048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A963"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204048.1">
        <property type="protein sequence ID" value="XP_038059976.1"/>
        <property type="gene ID" value="LOC119730972"/>
    </dbReference>
    <dbReference type="GeneID" id="119730972"/>
    <dbReference type="OMA" id="NCWIQND"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="220" mass="24723" checksum="BCBC6EAECA0D900B" modified="2023-02-22" version="1">MWTAVEARNMYVSAVKVFPEDTPHYMLKACLIAWGSPLIVLTITLAAATDHYRNEDYCFLEPDLVLFLGLLAPIGLILIHNIITFILVMRSILKVKEASRSQQISKRLQNAVGISTLMGLTWSFGFLVVIDGSQAFQLIFCLANSFQGLIVFIMFCVRREEVRTALAPYMKRLCCGRTCDIQVPWKKDRSYDLPILSESVPSSQSTAHTAEFDMSVSGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABJ1</accession>
    <name>A0A914ABJ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061113.1">
        <property type="nucleotide sequence ID" value="XM_038205185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABJ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205185.1">
        <property type="protein sequence ID" value="XP_038061113.1"/>
        <property type="gene ID" value="LOC119731898"/>
    </dbReference>
    <dbReference type="GeneID" id="119731898"/>
    <dbReference type="OMA" id="WIANIHH"/>
    <dbReference type="OrthoDB" id="5962960at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="582"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="651" mass="75131" checksum="576737D07FC45868" modified="2023-02-22" version="1">MSEGVHTQQSAEQPTLNIWDFAGQDLYYTTHQTFLSSRAIYLVVFNLCHDLDEPMPVQDQVRCKDGSGGSITSYRTTPIQYLDFWMQSIFTYTKENSSQDVQKSPPIFIVGTNRNSVGGDDLPDNERKALIDEIFTRIRLEIHDKPYNRYVVSEFYAVENSLEDNVKIEKLRNHIESIAMKEPYMKERIPLNWLTFDDEKANISGGKPVMTLKQVMDGFEIEDETELLTMLKFYHDLGHIIYFGGDGESQALKDVVILKPQWLIDAFKKILTVKHPRKQSKEYANSWGRLKNNGILDDSLIDHMWQDIFEHKTALLDLMDMFDLLCERLDKPSEEEHGSPVSSTAAAQHAQPCSANASYYVPSMLQRRTSSLQHETVENKNTSVFFVDFKGFLPDGLYHRLVVRALRWSQTFGGKDLDPGLLYDRANVFVHHDHEFVLQMVHRKDLAYIKVSVARLIVIPAPQNVKPPSTDVTCEVKDFVEEHLQSLKTTWIKRIKYCISVQCPNKLEEPHFLPLDDCLKKPEFLCRFKHCRALIKTEEIQAMFKQESSEEEASARADRQPMSDILFKEIAKDFGKERGEDLAKELGVESEEVDTNKKDYNTSGVNEQIFQILSQWRETRGNEVDKMRKELIDALMTVGKFGLAHKVQTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD05</accession>
    <name>A0A914AD05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myeloid leukemia factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061351.1">
        <property type="nucleotide sequence ID" value="XM_038205423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205423.1">
        <property type="protein sequence ID" value="XP_038061351.1"/>
        <property type="gene ID" value="LOC119732055"/>
    </dbReference>
    <dbReference type="GeneID" id="119732055"/>
    <dbReference type="CTD" id="8079"/>
    <dbReference type="OMA" id="MLMPFGF"/>
    <dbReference type="OrthoDB" id="8707547at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10248">
        <property type="entry name" value="Mlf1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30731" checksum="81D0E24A4D7318D6" modified="2023-02-22" version="1">MFGSMYRDFDEDPFFSDTMHDVHRRQMQNMQSMFGQSFGSMMSSPFMALEGGGGGHGHYPDGTGRTHRSYDRQQAMQPFGMADPFNMGFGGMFGNMHSMMANMHRNFEDMSNNPNVHSYSHSSYTSYSSDGSGAPKVYQATSSTRNAPGGVKETQRSVRDSEAGLEKLAVGHHLGDRAHVVERSRNRRTGQMEEKQDFNNLDETEADSFNSEWRQHSQHWNRRHTVSSRHRHNPLAITNGSRDRSPTRPTGPSTGGRHRSSHERRAETDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE96</accession>
    <name>A0A914AE96_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061684.1">
        <property type="nucleotide sequence ID" value="XM_038205756.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205756.1">
        <property type="protein sequence ID" value="XP_038061684.1"/>
        <property type="gene ID" value="LOC119732296"/>
    </dbReference>
    <dbReference type="GeneID" id="119732296"/>
    <dbReference type="OMA" id="MEWIEAD"/>
    <dbReference type="OrthoDB" id="10064741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1570"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1869"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1873"/>
            <end position="1890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1890" mass="213346" checksum="47A6E83E2459B3C6" modified="2023-02-22" version="1">MSQPQDDVLGQPTIGHTGDVAMANSEHSSHRSNRSNSSVASHLSGLSDKYAAKMRTLRKKIRVEELQHQLEEEEAADQALHRIDDQARQARLKAEEIERQALREREAISTNLSRQRRLRQAQQELVEAEAISAMISDDTTLTDVTITTTSQGTIPVCTSAQPVPSTSPVENRTVPDTSLRAIPSLTTFAVSQIPSMTTLVSGHPTPLCADGHAPMTTSRMSPHSAHQAQPVPTGPPPMVPGATAIDLLVASSYGIPKPALPRFSDGREKEFALLRMALDNLINVHPHLTEQYKFQVMLDRLGGRALKLAKSFMYTRQPYTEALAALTDKYGQPRQLVQCEIAAIMATPAIKYGDTEAFEEFSLDVLSLVGMLQSLEGPDGIELRCGSHVDRLLSKVAPSHRTSFMEHCLKEGILKSNCSQTYTLPQFASWLRRKSQSHSFASRAVSGHTLSNPRPQRYQEQRISRKDTPTAVLMTVPKPKYKPQPYCPFCDNKEHYLGGCPQLKKLNTDQIVSWIQDKGRCWKCGRAHKPDECTLKKPCHTCKQVHLTVLHDAAHKTTSHVFRVQTSSLNVYVDRPIRPHGVMLKVVPVLLHGPAGTIETYAILDDGSERSMLIQTAAEKLQLKGQPETVLLRTVRDDIVECQGSAMSLQVSPKGKPHIKYTINGAFSASNLCLSVYTYPVKALQQRYNHLRHLPLPVINQASPMLLLGADQTDLIIPQCPIRSGPRGAAVAIYTRLGWTLQGPTGNHDLQLEQRVFKTSTFPVTNDLLQHVQMLWQADVLPYANDKEVTRSKQDQYALKMLESKTTRVSLDGVQRYATPLLRTKDGDRFQVTKDAVLPTLRRAEKRLQKHPQLAKKHNELITKLVDSGHVRVLPDDEAAMSDESWFIPHHTVHHNGKYRLVFNCSFQYNNQVLNEHLLPGPQLGASLIGVLLRFRQHAIAISGDIKAMFHQVRLLPEDRPLFRFLWRNLKVEAEPQIHEWQVLPFGSTCSPCCATFALRKHASDHKEQYPEVAESVDKSFYVDNCLDSLPSSREAKHLVHQMRNLLADAGFEIRQWASNDPTVVEDLPPDARSNGCELWLTYGDTDSLEATLGLQWDCSTDNLQYRHRTVDYESLNMRNMYKILASQYDPIGYLTPFTTRARVIVQDLWKTKCNWDDVLEPGAIRDQWQAWEMELPALTDIQLDRCYTPLAVDVKPSSYQLHIFCDASERAYGAVAYLRAEDKHHHIHVSFVMARSRVAPKRQLSMPRLELSAALAGAQLCQLLKRELSLPVKYVVLWSDSTTVLTWLKSESCRYKVFVGTRVAEIQTLTDVKQWRYVNTKNNPADDLTRGKTLMELAQESRWRDGPPFLLSPPDQWPVHPATPPEDVSEYKKSTFCGAVAVDPEDPPDLSKCDTWEDLIMATKEHRDGAADTGDPPELGAEDRANIELLLYRRAQQGSFPDDLAALQAGRDLPRDSKLLQLAPEYDDFTGLIHVGGRLRQAEDIPKDSRHPIVMDPAHPITKLLIREYDEKLLHYGPERVLAEMRRKFWVLRGREAIRKHQRKCFGCQRWRANPDVPKMGDLPPARLRLYKPPFFSTGVDCFGPMTIKTGRRTEKRWGIIFKCMTTRAVHLDLLESLSADAYLMAVRRFVSRRGKPFEILSDCGTNFKGGASELHEAFSTMEPRLKEELSKQQVKFVFNPPKAPHFGGVWEREIKSVKAGLRVVLSQAVPEPVLRTVLIEIEGILNSKPLGYVSSDIADPDPVTPNLLLMGRHDAALPQVVYPARDLLSRRHWKHSQVLADHFWSRFIGLYLPSLQIRQKWQRDGAEMKPDDVVMIVDPALSRAQWPIGRVVDTFPGPDGRVRTASVRVRKKNYTRPVARLIRLPEVTNEGVKDDQENDKDPALMDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJZ3</accession>
    <name>A0A914AJZ3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064052.1">
        <property type="nucleotide sequence ID" value="XM_038208124.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208124.1">
        <property type="protein sequence ID" value="XP_038064052.1"/>
        <property type="gene ID" value="LOC119734556"/>
    </dbReference>
    <dbReference type="GeneID" id="119734556"/>
    <dbReference type="OrthoDB" id="10060229at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="685"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1715" mass="189414" checksum="634F7C79BFB49A13" modified="2023-02-22" version="1">MDMDTVMRPYLGQSANLLTGYKADIYSVPFNKSSKPALNDGQVIVRNPDYDAEWSWPTISLHDKAEDLLSAVLQIKLRPLEDVSDENGMAGVWPAGALILAGLSRPTSARSRALKKLSHQLGVNLKQQDWSYALVRRTRKIGTAIHPCYERGVFGHPYPETILKPDTLAALKSLEKMRANSTNVSKRGAEGYLDFYETFGSHFVSSVDTGDTIFQVFAFASTDYQNIVRVYEKSPNDLSGPKSTSFALFTTPRSGSGYGYTAAIGKICITSQDPEMVNSLKHGLWKDEKYACTNSIFAPFLRSDAINANTTFKKVVVISIELASLDVFAEYFRMLIWRRVFKAAMYAKYLTGVGVAPYFTNNCPYDLDSMFQDSDPIVGDGLLSTLATSSVNIWQEKLNLGDIALQFPELVKVFSVFANAIQIPATSSNEKTVIHVPGSSTVSLLGHVITSGGTGPRPPNLRLSDPALKEIKSRLFFGEFYGGLQISSSSDTKGFLIMNGLIFKEVKGQVSVVRDVRETLNVAILTERLTDIQFALVAAEARLNFLLSNAVPQGQSLKLLKRFLLWLAGVAGSNYQYQDDQLATLQARAMYLVSVVAADQGAGVPVPYLRYEAYKDVVENVQHVLRTASSQLMDYQKQIRARKAEERQVQRDTALNKNIVNSGKILQNYIGAQASYQQSLEDMFSSVYQEKMDELEKANKRADQLSARLSEQRVVVNDAIEEYKEAVGRWITEQNIKAAIDIASSLFSLGFTFAAPASSIGALSDLGLTVQRIQKAVEVFDAVIMTYRTIKAIPSNPKKVVDSLQDIGLSGLELPSSLEWDEMKVNFEATLASGPAIEAKNTLSAVFAVMVLRGKDLLQTQSTIQGIVADLSANQQRISLHKCQKKRLDELKVNLNAKPENLDVEKVDLIGLSGKLNFFQRQMLMTLASTMVIQDRALQYEYLRPPTRIESFTMLNLQLAILNQSQNINYGLTVQPQPKFQNYPIIYEIHGVTPDSITNNQRYTFNISLNKREFSSYNYVRIEGIHVEIGGITFTNSGKYYTELVFDGNPFFDRGFDGEPLEFQTTSRIFTGLHDVSTSSHVVYDHGNVQNPDVVLATTGQDHFGAKTSSITPFSSWQVSLPKTQSNEGIEFDDYSRGVTVRLIFRIYAQLKESTMTPSEMNSAARRLLTRQDYVKPIESVLPMALAGKLPTARPSTSDGATTTTSVSRDDVLRAMKGTSVCAGWDVVFSMTAKRVNDQLYGQYANRKDNPVFIRETGNIEKEYKTSEGKTLKTVFNFTFNAPRLQFLLNNSNSAQVFMPIISGTYEYSVLVNDTWIELEKAEVKKTDGAFIQGDVPLSIVPGSVSTQHNVAIKLNGGSFSARNFKAGNTNPTFGFALTNYFTSLKDGYEVYNLGTLDLKGITILDSLNPNDFQFNVYHTPSNRDLLQLFIATTGRLQSATSLYIQEPIPSTYDSSLIINSKIFFQDVMPTALGDGGIGLALEAIEPPDDANTNTAWSAKATSGSVSAPFPVTKVDSDATSNKGSTTHFEYFVKVGNDTAVVDLTGMQFLPGDETSGWVAKVVYSPGCRKYSFKYGSRWKICTLFGCDEWSKIDYSNHSLGVTIDMETTLPLSVTGDGQNQSIGFAATESSVSLTGNLKPPGGVCKCNDRDLQKKFLDNLKKILPKELVGVFNKSFDAVSLFALKNLLFPAKNLITLEEGAVPGDLIVFGNFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALI7</accession>
    <name>A0A914ALI7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064187.1">
        <property type="nucleotide sequence ID" value="XM_038208259.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064865.1">
        <property type="nucleotide sequence ID" value="XM_038208937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208259.1">
        <property type="protein sequence ID" value="XP_038064187.1"/>
        <property type="gene ID" value="LOC119734717"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208937.1">
        <property type="protein sequence ID" value="XP_038064865.1"/>
        <property type="gene ID" value="LOC119735229"/>
    </dbReference>
    <dbReference type="GeneID" id="119734717"/>
    <dbReference type="GeneID" id="119735229"/>
    <dbReference type="OMA" id="VANADVM"/>
    <dbReference type="OrthoDB" id="10068084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="18729" checksum="93F42022A8A9CA46" modified="2023-02-22" version="1">MDILEVVEKVNARVRVLSTQKLLGVCEHLGLETGDTAEKVNGHQRLVQNTYSDEVLDRADGGIELLQGLDGFIDGIAGPEVVPDEAAVSAKSAKPDSSDEPLEVQPAPLKLVPAKSEQPTVGPEVLSLMRREFKIFGQIGEPGQKDRLTFTSLAHQIETGREKGYRTVKSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMJ5</accession>
    <name>A0A914AMJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064813.1">
        <property type="nucleotide sequence ID" value="XM_038208885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208885.1">
        <property type="protein sequence ID" value="XP_038064813.1"/>
        <property type="gene ID" value="LOC119735180"/>
    </dbReference>
    <dbReference type="GeneID" id="119735180"/>
    <dbReference type="OrthoDB" id="418634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="3">
        <location>
            <begin position="74"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="598" mass="66857" checksum="FC620F29D2B1C9BF" modified="2023-02-22" version="1">MKSALMSCGERHHVDFIQAETSSVVLSPPENEGELQGSPPTPATHLNRILQEHDNFAKDCSEDTLKDNTFQLPYIAIGYFDHDGGSLSLDKYNVHLYIPRGALPKDSLQQVYIYVNPNAPPVDGIDPSDCVLSPMIQCGPTGLEFLDSVVLSFPHFAKEGSGWELRAQLCNDEEGSLKTWKTLAAGVDGEVVSTKDKTVVLLMKHFTGAALVGQPSATSTKIMKAGVFGSPFDPSDGRYSFRFRLWNVEPVVGENVFEMEKEMSSEQLDASKLLKVCRSGDVHAEIENIKEGWELAIPCLQKQTIPIERIWKLPTDFVTFHLDRRNVNEASSCKGPSCESSIFQSSIETGEASNGDKAHFIIIPPKVKESKRERDEQSPCYSCRQDAAHEICPSCKEAMIGVRVPKKRELSDGDYGGLSEELVRTLSQQRDMARVVVGLADVGHSVMQAQDSLKVFFGRQRARGVQDRTAVKRLLESLDKHIVKKVREELQGAENSPDDGSISKGRTDDCSWLASEIDDEKRFRWLASRLGPEWEALATELECTNADLFKIKEDNRYDVSNQIFTMLVQWKQRWGWLDNRILAGALEKAGRRDLAQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMX9</accession>
    <name>A0A914AMX9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064958.1">
        <property type="nucleotide sequence ID" value="XM_038209030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209030.1">
        <property type="protein sequence ID" value="XP_038064958.1"/>
        <property type="gene ID" value="LOC119735334"/>
    </dbReference>
    <dbReference type="GeneID" id="119735334"/>
    <dbReference type="OMA" id="IKVCNGQ"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="221"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="314"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="507"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="514"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="89646" checksum="62B87D2411CCB53A" modified="2023-02-22" version="1">MTVYEGSQATLICNYTGSSIQSLEWMKDDDGAIQSPTQIAEIIYHIGNEPIYHNGYNSSTYTASIDWHTNTFNLLIHSVDVAADGGTFWCFARYWVGTLIISSIDLTVIVLPKTIALSDSSTSYPSAGGTAYLLKGMDHRFTCEVPDINPGASFTWSLGDATITPYNTVNVTGADKLTTSTSMATFSPTWSHHGKTLRCQASNDEEYEGISVNIRLYVIGPTETPVITGSTSMTENEATLLTCTADMGYPDDWTLVWSNGGSPGPTTSSSESGDRYSFTSTLDYTPRRQDNGNIITCTANRAPWIPGPVGSLGPIDVKYEVNITNKAMNEVRVKDGENAVLICIAVGNPQPLMEWYCTNNTMITSDVDEGKFPVTHETSGGDGIFEFKVTSKLTVKAVDSRVDYGVYTCISSNGIGREDSLNITLTEIMTNVPPTTTVPDDKTVVIIGIIIGFVVLTVIALGVYVTRRSRKASGELDCISQPANKKPGTVDYANVPTAHKAFPRDQLKIIKELGHGAFGQVLLAEASGMTQGSKVTLVAVKTLKDGAGNSEKADLMRELDLMKKLPDHCNVVRLLGFCVEEDPPYIIVEYLSRGNLKDLLKDSRSKGRRVYGNLHGISKSLTSKDLMKFAKDVADGMAFISSQRCIHRDLAARNVLVAEDMTCKVADFGLARDVMNIRVYERRSQGPLPMRWMAFESILDDVYTTESDVWSYGVLLWEIVTLGARPYPAMTAKIMVNELQSGYRMPKPLHCQEELYVMMLRCWYEDPDSRPTFKMISKELDKLITKEKEYISLDDFEESIYEVALKDDAGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN78</accession>
    <name>A0A914AN78_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064956.1">
        <property type="nucleotide sequence ID" value="XM_038209028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN78"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209028.1">
        <property type="protein sequence ID" value="XP_038064956.1"/>
        <property type="gene ID" value="LOC119735330"/>
    </dbReference>
    <dbReference type="GeneID" id="119735330"/>
    <dbReference type="OMA" id="LCIERNT"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="199"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="613"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="782"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1138" mass="125305" checksum="4487F8554B09450E" modified="2023-02-22" version="1">MGDIYFSEELKVYRSAPRCYSSHVLNSSCFDYNFNFNINRPAIAHKLSITFNSDTALLLKIIPIIAYDVRLRVPGIEYLLYYYNQEEHKDGYGKVNNVNDTAVKINLQLVPPVALKTGFFNMIFAIMPSQGVEDLLQRILMTAEVSVIECDQGDGCEGFFKEWSRLETEFKESKCGNGLQQEYLSYQQCRETAEPGPAPIVSSSAQYLIEVPSDLPSGQPFPVECHIENAATYEWYRTNADGQRDFVTNGYALIFPSFEELRDQGAYVCVGRGRGLLINVTAEYQAVVMKSGITTLMANTTFVNEVFTDDLRDASSVAFKNLTDKVRSKLPLNTIYPSVVSYDIVRFYNGSVIVDIKVVVHSPSNVSDADTISSLQRAMSTYASENSDIGLDPDTVKVVSLSSCAREILELEGQNVTFPQTRIGLNVELLEECAIDGKQGRVLISRACSGDFTQGAQWLVPVVGNCSVDVNGQLDLLKKITVTSDNVMEVSESLESLTSDASSVNGESVVLVADILDNIVKIQNPSPEVTSNVVHVASNLLEVDDEAFSSLPNGDSTSRIVQALETQISYVLEDGANFTAISRSLAVQALNIPPSSLDEGVGFVVIEGETTDGVLTNNSVSVYFSVSEFPPETVESSIHLPDEILLNHPTASSPVPISFIVYQTSTLFRSKLIAEAESTGSRLYVNSAVISATVAGVHIENLPADDPVVVIFYQNPLIEGEGAEVQCVFWDNQLQDGNGEWSTEGCRQFTSVSERTVCHCNHTTSFAVLVDIHGQKYSSLALDIISKIGCAVSIASLVFTIIIYLAIKSLREKTPSRILVCFSFSLLCLYLVFLIGIEQTSSRIGCIIVAVLMHYFTLSSMAWMGVEATNLYLKLVRVFNSNVVHFMVKASIAAWGLPVVIIGVILAVDYTAYENKNSCFLKPGAAFYYGQLLMIGLVFLYNAFIFVLIARRLTCKAKVIQSSTTKGKRSQMARRLQNMASISVLLGLTWAFGLLSVIESSNFAFQVLFCVFNSLQGLFIFLLFVLRQDNIRSKILGFFQKTPAPSGTLSSSAPNTKSQPRFNYVGNSDNEIQENVFDNRAIKMDEIVDKEENVSDKQAGDQSKNGENVEIEDDVHDNQATNQLKADVIVENEDNVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANQ6</accession>
    <name>A0A914ANQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065064.1">
        <property type="nucleotide sequence ID" value="XM_038209136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065065.1">
        <property type="nucleotide sequence ID" value="XM_038209137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209136.1">
        <property type="protein sequence ID" value="XP_038065064.1"/>
        <property type="gene ID" value="LOC119735437"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209137.1">
        <property type="protein sequence ID" value="XP_038065065.1"/>
        <property type="gene ID" value="LOC119735437"/>
    </dbReference>
    <dbReference type="GeneID" id="119735437"/>
    <dbReference type="OMA" id="CMVGLKD"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF76">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="336"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="21">
        <location>
            <begin position="453"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="823" mass="90660" checksum="F2E48B7789953EA1" modified="2023-02-22" version="1">MDNMTDAPKICEGLILPLTDESGWSLWFRIVIYLVGLLWSFLAVAIIADVFMVSIEVITSRTRVLKIANPDFPGGIEEVEIRIWNDTVANLTLMALGSSAPEILLSVIEVTGKGFKSGKLGPSTIVGSAAFNLLVITAVCIMSIPKGESRGIRMIKVFATTTAFSLFAYIWLFLVLQVISPNKIEIWEAVVTFMCFPILVVVSYIFDRDFCGTKKHEPDMELGIEPSRNILSTPEHAESPCSDQCQAEGSPFLTSGHVDKKAVAEFMREVGKHPDLDESTIAQLIALEAQKHEVHSRSWYRVNASRALLGQKKIEQEVEPHVLDLYQKIKNKEMPTNIPTADHSAGGTKAVVEFRASSCAVYENEKKVHIVVERQGLMSVQAVVRYETVNGTAEAGSDYIAQRSTLVFEPGETEKIIEIEIIDDNEWEPDETFFVKLAMDPNEETCLGHRSVMQVVIMNDDEPGMLEFTKTSFLVKESAGSVFVPVSRNQGVDGRIEVQWRTKDMEALNGSDYIGGEGTLVFEHNEKEKEIEIPIIDDQEYEKDESFQIELFEPTGGAQLGRLKKTVVTIINDDDYAGILDRVVAITHVNMDRLKMGNASYADQFKDAMNVNGGDLEGAGALDYFMHFMTFAFKVIFALVPPPGFLNSGGWITFFCALGMIGLLTAIVGDLASIFGCLINLDDSITAITFVALGTSLPDLFASKSAALNEKYADNSIGNVTGSNSVNVFLGLGLPWLMASLYWAVRDDEFIVPAGDLAFSVSVYTICAVVCICVLMLRRVLAVFGKSELGGPFGPKIGCGVFLIFLWILYVLLSSLKVTRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQA3</accession>
    <name>A0A914AQA3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065619.1">
        <property type="nucleotide sequence ID" value="XM_038209691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209691.1">
        <property type="protein sequence ID" value="XP_038065619.1"/>
        <property type="gene ID" value="LOC119735768"/>
    </dbReference>
    <dbReference type="GeneID" id="119735768"/>
    <dbReference type="OMA" id="ACHACNP"/>
    <dbReference type="OrthoDB" id="7952570at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037495491" description="Fibrinogen C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="190"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="412"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="642" mass="71297" checksum="1169BAEB339B6BB8" modified="2023-02-22" version="1">MWIGPTLAVLSWLIVPLHAATPSCDGPLSRAVGMDRVSRNVALNNHVLRSCTTRSSIVCMAACLRQDQCVSINYEGAGGTCELNGSSMEAHPADVEVRDGWKHYGNLPGTVAEEQICQTPTTNQPTTNQPTTNQPTTNQLTTNQPTTNQPTTNQPTTNQPTTNQPTTIQPTTTQPATTQATTSVPTTEVFTTEKPPVDCWDIHASSPLLPSGEYAVYPATHNGPLQVYCDMDTDGGGWTVFQRRIDDTQDFNQNWASYKAGFGDLSVNFWLGNDALHELTTQQDYQLRIELQSYYSQTTYTKYGLFTVADEANKYRLTVGLFYGSYVADDSMNYQNGMAFSTLDQDNDVDVPRHCAQSFLGGWWYTACLSSNLNGPFVNGPNVPQNAQGVIWGSWLTVSQSLKFAEMKLRPVSAQSVPKDCWDHKLQGQTASGLYNIYVTGKPQAIQVYCDMDDVGGGWTVIQRRVDGSRDFYLYWADYKAGFGDPADEFWFGNDDLHLLTNQSSYQLTVKMESWDFVIRYANYEHFSIANEADKYRLSVSGFSGSSGIGDSLGPHNGYMWSTQDQDNDIDLGRHCAQHTMGAWWYHSCEHSNLNGPFVASPGYLASDAQGRGIIWGTWKLQSYSFPKAEMKVRPSHMGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARC4</accession>
    <name>A0A914ARC4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066312.1">
        <property type="nucleotide sequence ID" value="XM_038210384.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210384.1">
        <property type="protein sequence ID" value="XP_038066312.1"/>
        <property type="gene ID" value="LOC119736371"/>
    </dbReference>
    <dbReference type="GeneID" id="119736371"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14693">
        <property type="entry name" value="bZIP_CEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="157" mass="17799" checksum="AFD1632AD346860E" modified="2023-02-22" version="1">MPSDNRKPXGGKQTTAGRSLKKYLHDKESDEYKTRRQRNNVAVRKSRDRSRKKAEETQERVQQLKEENQQLESKVMLLSKELSLLKDLFLAHAREVPDPSTTFGLYTAGPDVASRLQNQEVNSEQPGMESANNQLTQASSDHTYVVTVNQEGVKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARY8</accession>
    <name>A0A914ARY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066815.1">
        <property type="nucleotide sequence ID" value="XM_038210887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210887.1">
        <property type="protein sequence ID" value="XP_038066815.1"/>
        <property type="gene ID" value="LOC119736877"/>
    </dbReference>
    <dbReference type="GeneID" id="119736877"/>
    <dbReference type="OMA" id="THRITWN"/>
    <dbReference type="OrthoDB" id="6129242at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586886" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="333" mass="36836" checksum="B80261535AC62345" modified="2023-02-22" version="1">MTAQPTVSGRCSLLLLAWALLAGLWASGGVDALMQPWCSVIDRALVGWNVSSSPTPTHKLCHLACLDAPGCQSANYWYRKKECDLNSVSHWNVSGRHLVEKAGSVYTFTQQDAGCDVYSESSCHGNEPKTHCSDDIQDPEWRLVFKGVAGTGVKLHDMWTTMNWKSSYEASCHRRNNSLYRAWRNGQLNIRRVKLSLYEGARMTAELIFDGTGSDIKNWFTQTRLISSPWDDLKSAALTGSVGSGQLFSIDGDDREVLDRRFFINNGYGGCEVDNGWLIVTESAATGKCLWETDTAAHPYSIILYSATNQKVVWSQAGTVGIADSLTIHIHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASK3</accession>
    <name>A0A914ASK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066444.1">
        <property type="nucleotide sequence ID" value="XM_038210516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210516.1">
        <property type="protein sequence ID" value="XP_038066444.1"/>
        <property type="gene ID" value="LOC119736499"/>
    </dbReference>
    <dbReference type="GeneID" id="119736499"/>
    <dbReference type="OMA" id="GMAICWI"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="45"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="42367" checksum="66C77BA18A2B5ABA" modified="2023-02-22" version="1">MKTLAPYSNGTDTIDAENDSVDNGDTFMIFEVVCTFAMTVLGVPGNCLILRVYHSKRRRTTTHIFIMALAWADLLSCLVSTLTAASQVMMLAGTPMPEALNNAIVYIRAVPLTVSLFITVMIAIDRYDCTCRSLRRVLNQRRAKMAVLCSLVFSVLISIPFFLGYVYPNSLVIKKTRIVTQYLSFFMAVSSVTFCYGNVYWKIRQHVRVGVTESTATKAPPSNSTSETMSAAIVLRTQTVNVADRSLLGESSGGAASSAPALDAWQPRETAEAADTPRRVPPGRQLEGGRSLNANLQRKTTRMLFITSVVFLLTWLPYWIYLAVYMAALSGAQIDPAVFNVFLYLIYTVYVNNVVNPFIYGLANSRFRKDCLDVIRKLKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT60</accession>
    <name>A0A914AT60_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066664.1">
        <property type="nucleotide sequence ID" value="XM_038210736.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210736.1">
        <property type="protein sequence ID" value="XP_038066664.1"/>
        <property type="gene ID" value="LOC119736723"/>
    </dbReference>
    <dbReference type="GeneID" id="119736723"/>
    <dbReference type="OMA" id="ILEDMNC"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037541359" description="receptor protein-tyrosine kinase" evidence="22">
        <location>
            <begin position="30"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="287"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="513"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="614"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="713"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="808"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="904"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="1228"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1524" mass="165570" checksum="992365063EE0E10F" modified="2023-02-22" version="1">MASQGGDYRHFTIFSLLLFLLLTHTGGLALNLQNKPTSQSSTYANEGRAENAVDGDRTTISHTNFAPNQWWRVDLEAIYCLTKITIINRDGFGYKLAGAVVRGGLDPADFSQNTQIGDAVTSSQATNGAVIDFIADPIVSARYVSVVLNTTQILALAEVMVEEIQDTEDTSSVAGGVDFTLVANPSWLGATGDNDATLAAYKSPTDIAAAVSFGRQLTTGGSNDNLPAGSSGFYDANLGCTARLLSLPQDGGIGRTGVFYGTAALNGMATTIRTVILRKDGTIHTRPVFRTQTASIGEAVTLRMESVNPPNINYRWKHNANSEQEWDGMLSVTIGNVIKTNEGIFSCFIDGEEDQQLHGFMRLIVRECAAGMWGPPSCQNTCRRCYNGGICDDKTGTCICAPGFSGENCQQVHGRHIFGKNASHTCSDSTDPHNDACQGRLFCLPDPYGCSCAAGYMGLDCTQECSEGKYGADCKQTCHCPSGDSCEKDTGECTGNCILPYFGSNCQCSTDNGVLGLKVMPIDRYQLQVSWQPDACVFGYILEYALTNRGQCEEIVSPQRVPLPGPLDGQTTSHVITGLISSSTYMVYIRPQYSSTQGPEASTSGTTLKQENPSVSPVVVTSYDSASVTLSWREVYCANYSVQYALENKEGCLPINPLNFIQHCMCSGTNSTVIPGLFANSMYEIRVQAHVDGSSGLTVQITVSTSTKVPSAPPEQVTVDSTAKRSLTFSWSQPACGSRGGIITGYTYKLSGPGSQLITDVSTAEQVEIDALIPFTNYSFQVAGNTIAGAGPYSGVVVQRTAEAKPTVPLNVVIKNVDDVSITLQWSEPDPPQGIIIHYNIRYWRNGQSGNPTVINDVVQLMHEITGLEANVTYFVRVQAETSVGAGPWSYEVTAVTTIREPGPIQNLHWTERTDSTIALDWQPPLNPNGQIQRYIVEYRATDKPHQPGFTAPDEYERNEVESPPFVKDNLEPGTKYEFRVAAENQLFIGRDTVLEVYTKPQSGLPAPPQPISYQGDATDTTVTIGITTAVSGDDFIESYVVHVKKTRSSSVTRRDVLIPSHFEDSPNDYIAAELPKGGVPDKFVVGDTKMYGGYYNAPLQTGAVYNIRVGSVSKGNESVANVEFSEPLTIKVEQPSSSSGPIIAAVVLGIGLLVVLLVAAFILWKKRSAARSQQTATDELVLSENPKPKINKSESLNDDDADPVVYEDIGLLPSWASKLEIKRGNLIIDDEILGKGNFGEVRAGGVKIKGKVTKAAIKTMKGSVSESSRDDFLKEIQTMAGIEPHPNVVGLLGACMHEAILYVALEFLPNGNLRDYLRSTRPEQQGAAGSQDDVSPLTSSNLLKFGLDVAIGMEHLSNTGIIHRDLAARNILLSEDLTAKVSDFGLSRGEDVYVQKSSTRIPVRWLAIESLTRRVYKSKSDVWSFGILLWEIVTYGSTPYPGIESKSLAQRLLDGYRMPKPENCADEIYDVMLKCWQEQPSNRPSFRKLVEILEDMNCNPDANDYLSPTVYENFTIKPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATP9</accession>
    <name>A0A914ATP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067048.1">
        <property type="nucleotide sequence ID" value="XM_038211120.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211120.1">
        <property type="protein sequence ID" value="XP_038067048.1"/>
        <property type="gene ID" value="LOC119737048"/>
    </dbReference>
    <dbReference type="GeneID" id="119737048"/>
    <dbReference type="CTD" id="79925"/>
    <dbReference type="OMA" id="IMETKQQ"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056199">
        <property type="entry name" value="SPEF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054517">
        <property type="entry name" value="SPEF2_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24082">
        <property type="entry name" value="SPEF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22946">
        <property type="entry name" value="SPEF2_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="947"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1502"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2012" mass="226064" checksum="3792BC4F0C7F580D" modified="2023-02-22" version="1">MTEILCRWLNSDLYISQPVDQKNFAEKFASGFLIGEVLKKYELQDDFESFSQSRTADSKLNNFTRLEPTLHLLEVPFDTNTAHGIMQEQPGVATRLMYELYIALHNKRQSNLTGVAMQTMRAGAPVKLESLERGPYKERLKILTPRQTDLNLDQLVDKFRERKRQHLDVEFRTRYEEEEKQRQWQQDERLRELQKAADARKRQTELVARIKAATVEMPKPPPNKTLKAITARREASLKREASEMRKQIAKFENQLSRSLNMTQEDKDADEEVATYLQQQQEEEKSKPELVQLIRPASNDEYISKIRKRLQEDATARQEREKRRRKVLVDQLKAHDAQEEARREELLVNRLMRQSQQERRIATQLLQLRHEKAVICQNRIFREQQYEERRQRDFQEALDKEAELARLAKLEYIEQTKQDKELHDKIAQERAEAKYLKRYNICQDILLDLVDLSCKVGKYRELTEKQLPAKLMREWKMLFSSGKPLYEQPIEGQDEEPVESAEDQLLGKERQSLLDEGDFLEYRNMVGEWQPPVDCDIKGPQKNNAVLGHILARIFSIVSPPTPPPAAPEIPPFPVKACFLGKAFTGKSSVASQLAEEHGLAVLNIDDLVRDAVDAYKDGEVMDVPSPAPTEGETVEGAGGDQQPAVPISTEGSPSGQPGTPGDVNATSATPNAVTPNPEAKDSKEKVDEEKSDIVKEAGEGTDKATEGESSESKTVKKPPSPTKKKGSAKPEPTARAKLGKLASKFLRKGQPVKDELLIDIMVEAVKRTTEEHGWIMDGFPSTVAQAKLLEKALSGYDANAKPSRSKLRQSRLALDPNPPKDPPPPVSGIDLVLMFESPDELVLKRAAGRTYASQSSEQYQQEFRPPPEGSCTGVGKQEKVSAVKDAAHDQEQIQHRLTGFQDAWKKLDKWFSSFGILRKVDVASEQQEAYCRVEDVMIETKDKIQKAKEDAEKQEEELLKAATEGSTAGPTSEVPTTQPTEGMDSTATQRGDTQTGDGVMSEAGKESTPAVAPGSPKGSRAGSAKRSRSPKGGSPKRGNSPKREKSPKSGKRDREKKREGSRSGSAKRSPSSGKGKRGKSGSPKRGKSGRKSPKREPTPEPEPEPEPPVPTGPPPPQPGSEDWVYVDEPIDEALALVIAPHWENTEATYVASAKHVFHNIRDERENIYHYFYKVRRDFEDYLRRPDGKQEFLAAWQQEYNEIAEDMRDDDETKSELHQRVQDLKEQLWEMSDNRKVDAETERTSVMEEGWLEDRLGLLTNHYLTLMQSEVDRYQDTLRLLKDYYQGMEGKIPEEFDSAFVRIPLIDLSTAVERPSSAPVSAQASESVTRAVTPTTPSAKGKKGKEPPPEEAKDELEEEKPKIPLVPRRPTSTEGFFPSQTPAGKAEKGSKSRAGKKEKEKPAPVTSLEETQESPLPPTDADEKLIFDAFQFGMMKISEMTAAELAARDAEDEAEKLREAENYKEKEKGAAKKPGKKRSKSKSPSGKRSPAGGKKSPSGKKSPVGKKSPKKGKKTATPTPPPTPPPATEDTPEERAKKELRDRMKQEYLAAISHEEGGLKMRMELTKTHAIAVLQELKAKAEEVYKDMDDWLGGRFQQEMDSIDTLAEVLGENIEKKEKVQPELVSLQDDFIVNKEVKVFRTPSPPPRPSPTEIAQPDTFTVDQMRVLHQQFVCSAPSGFISNKGFVDTLSDMTALTHGTEALPDNWMGLNLNQLEQLAAILSPDCEYVDWRTFMLQVAQPWPQPSQAQLLDALQGFRAMDTLNMGTVTREQFEQVPLWYTTDPSPPVPDDPSKPLPYDRVTHVQKLFFDNFADHAVQPPVVDYTNMLLYFSIDQDAMNGLFRALSIASGKHMPRPRLEEIESKEKQLDQLNVMKEVVEVITGGEIRLQDKRVEPSLGPPEEGIPSSALHATVDLKALVQVLHHGRPTLGDSHRFSVTSDPEDTFSQERLASVYRELGDNKLSPVPFFTLVDHPIIQDCLAMCHRYKTPDLRPVFAAATTTILIDNDATSIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV63</accession>
    <name>A0A914AV63_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067985.1">
        <property type="nucleotide sequence ID" value="XM_038212057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV63"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212057.1">
        <property type="protein sequence ID" value="XP_038067985.1"/>
        <property type="gene ID" value="LOC119737599"/>
    </dbReference>
    <dbReference type="GeneID" id="119737599"/>
    <dbReference type="CTD" id="65095"/>
    <dbReference type="OMA" id="FEHEDWE"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="508"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122856" checksum="04CF8E50204AB6D4" modified="2023-02-22" version="1">MSGSEDDLEFRINTKFAENYDKWRRKEELQKLKDRYGENFAEESSSSSSEEEDEDAEGLTAQIEKDFLKTLSYVKSRDPRIYDKDATFYHEQESSSDGSSGGDAPPTKKKKEKGKQVKEDKPVFLKDYERQIITEKGGRYSDEEYEEEEDEEQFGRAASLTYVQEQRAIKDSFQKALQSSDESDDDILLKKRPKTPRERKAEEEEYIQWMKGRKETVDDEKTAQDAAEMEALKRYWTDPSLEEGEKFLRDFILNKGYKAKDEEGDEPGIELEEADFSEEERLLDTQDEFERKYNFRYEEPDSEFIKRYPRTMASSVRVKDNKRAVKRQDRKERKQQDKERKKEELKQLKNLKKQEILDKLEKLRQVTGNTAVGFEDMDLEGDFDPEQHDNAMQKIFSEQYDALPEEDTKPEFEHEDWEDENWDDWDGQDYGEEEYYEGGEEEQYCEDPDFNMDADYDPSLSKQANMERRAALQQELIGSSKKKKKKKLSKFAEVLKTKKPVFNPDDRTYEEYIEEFYKLDYEDMIGDIPCRFKYRKVVPNDFGLTTEEILSAKERELNQWASLKKTCQYRTEEEEERDRRIFAKKAQNEAKKRRVFLSLLEKPSDSEDSGDETKPKKVSNTASKQPTSQTKKLGRKTAKASTIPSSPEKQKSEPGSPSKKVKTDPSSTRSSGRSVNRNLEEAPKSETNSTGVQNPANLENVSKKKGTSKKTRKASKGTDPKPDSSKSTIPTEKSTRGNTRGFSTSIKQRVDVVKNEKSEQSGNKDVHGERTNAAKPLIKKRKRKRSHSEDKPKLKIIDAYASEILDIPGLSNIKKNAASRTDPTSATKTSDNTHRTEKNQKTKVGKTQNNSDMDTKSKASIHLEPPQTDLQSPGRTDSKKRKRKRKNSEQQSEPTPKQSHKETQNNKHNVSETISSKPSTETTPRSKSDFASIKQKLKKKPLTMESTKKDQASSKVVKVSDGKGKDASKNIQPASAASPSSKKKQSKKQSAQQISAAAAASGTSKSNRTRNKNRNRRLAKKQKSPQAVTGTTVSDARLKAYGINPRKHGYRMKYLREQEAKKQKQNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVY8</accession>
    <name>A0A914AVY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Calx-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067858.1">
        <property type="nucleotide sequence ID" value="XM_038211930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211930.1">
        <property type="protein sequence ID" value="XP_038067858.1"/>
        <property type="gene ID" value="LOC119737512"/>
    </dbReference>
    <dbReference type="GeneID" id="119737512"/>
    <dbReference type="OMA" id="IELWEAF"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF70">
        <property type="entry name" value="CALX-BETA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="389"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="532"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="898" mass="99169" checksum="6FB49BB6B93AC4E1" modified="2023-02-22" version="1">MGNNQSETLVNHYTNYSNGQVVEYVPSNQEPCKSWLLLPAENLWSVPLRGILYITAMLYIFVGIAIVSDIFMCSIEMITSKKRKILRWDSESKKHVEKEVLIWNETVANLTLMALGSSAPEILLNILETCQHVQDYDPNNPQDSLGTFTIIGSAAFNLLIITAICISSVPSPDAKKVKEFGVFMVTSVWSIFAYIWILIVVVWNSPGEVEIWEAWVTLLYFPLLVMNAYCQDNGWWIKRPKVGGTEPQSGSQMNIRVVNGNVKKHHVFHGPSPQLAALEAERSQSQMNLKATTDERTNDMLVLKDLEAAPEDGRVERSDEEKKQLARASSSRNRFACTFTPSLGGFRHAAVRSILGGKKRVNGYKPSSASHPRLMELVDKVRTMQDGSSEVPITEDLRGKFTFAASSYSVLESAGKLEVDVLFHRTIPKSNGALMENGKAAAYEVQEDNSKKEDDSYINSVVSISYETREGTAKYETEFRYTQGVLIFQETEWRKSISIPIINDNQFENNMDFYVILKNPDGGGALGDPSLTRVTIIDDDVPGEFSFDSANYAADLEKGIVTATVLRSNGSDGTVSIQYATMDGTARGGLDTSVADYRATSGTLLFEHGETSKQIEVEVNRKTKDPKNFVLTIRNPSLGAKLGEHSAAVANLALDDISERLANLLAENEEEEEETWLGQIKSAMNVGGDKDEEGNEIPPAKIDYLFHFITFLWKVVFSLIPPRSIWGGWPAFILSLACIGVLTAIVEQLATLFSCVLYFKAAVAGITIVALGTSVPDMFASRTASIHDQYADAAIGNITGSNSVNVFLGLGIPWIISVMYNLATKKGPFRIEQGNLFMSVLLFTGIGTLCIIILIMRRKLFGGELGGPKITKHLSGAFLAILWLVYVTIMCLKAYTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW62</accession>
    <name>A0A914AW62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038067744.1">
        <property type="nucleotide sequence ID" value="XM_038211816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067745.1">
        <property type="nucleotide sequence ID" value="XM_038211817.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067746.1">
        <property type="nucleotide sequence ID" value="XM_038211818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211816.1">
        <property type="protein sequence ID" value="XP_038067744.1"/>
        <property type="gene ID" value="LOC119737453"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211817.1">
        <property type="protein sequence ID" value="XP_038067745.1"/>
        <property type="gene ID" value="LOC119737453"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211818.1">
        <property type="protein sequence ID" value="XP_038067746.1"/>
        <property type="gene ID" value="LOC119737453"/>
    </dbReference>
    <dbReference type="GeneID" id="119737453"/>
    <dbReference type="OMA" id="TIVGDHK"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000216">
        <property type="entry name" value="Tyrosine-protein kinase SYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="179"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="423"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="693" mass="78471" checksum="BB9D8B18DBD287A9" modified="2023-02-22" version="1">MMNGAHGASKRFGESNPQDPITVRYYHGRITREEAETRLRNSGCMQGDYLLRDSLGKEGHYAISLCFDGNIYHYAIERQHDGGVAIKDGNKFAGPVELVQHHEKKLDGLLCLLERPCCLTDGQKPRAYGDLSHEEMEDEIALVAQNQGLSRDTIQKAIASNRSQFDRLVKSILHQERPWFHGQLTRTEAEQRIVTSGLQEGKFLARERSEPGSFALSLCYNSSVYHYKIDKDCTGMLSIKDGPKFDSLLQMVDHYTLKKDGLLCCLMVPCIDPQKRRHSAGPAATPSPGYRRAQSAEDEPMPVRTPPAPPQPRRVNTQSADEATLGPFMPPPHPMHHPAPYHVSHPLVPQPHPPRQRPMIEQIVNGKWEEPDHHADEPSPQRASSQEPPIVDDKTYGIPNDREMIYGRVAKMRNTKILEVKYLYCGEPIGKGNFGSVLKGSYNMHGTHIPVAIKTLKTENGIPNSKPEIVKEAEIMADLDHQHIVRMIGICEGFEMMLVLELAELGPLHKYLKRHTNMSIRNVLELMLQVAKGMQYLESQKFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGRWPLKWYAPECIYRFKFSSKSDVWSYGVTLWEALSYGKKPYANMKGQELMAFIESGSRLAQPDRCPHEAYALMRQCWEDEARDRPSFDNIVETMTSIIRGLRAGTLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWK5</accession>
    <name>A0A914AWK5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068490.1">
        <property type="nucleotide sequence ID" value="XM_038212562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWK5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212562.1">
        <property type="protein sequence ID" value="XP_038068490.1"/>
        <property type="gene ID" value="LOC119737910"/>
    </dbReference>
    <dbReference type="GeneID" id="119737910"/>
    <dbReference type="OMA" id="ASFFMYW"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="449" mass="48741" checksum="26DF7DADDBF86D77" modified="2023-02-22" version="1">MNTERIAHKDGGWGWLVVGSTFIATFLRSSTVKVFAVLLPSIRDDMQLDTWVVGWLISVMFTISDFTGLPAAWLCSKSGHRLVVMTGGLMVGIGIVSSSLAVGTAHLLLSAIVTGLGLGMVENPPLALIGRYFQARYATANSLALSAIPIAIIVAPPMAQILLDTYGWRGTLLMWGGACLHMAVCGAVLRPVVIRGVERRDTPTADEASSPDRNEKTRTRRMRQFIQSSHLYLLKNFSFVTIVCVLCFERLTFLAWLIYLVPHGLEAGLTPYQAATLPSGTGVANLLGKVVQGVFVDSKLITSTALLYATAVTAGVSLMLDPLAKTFASMFVLGTVYGLAVGTLYPLGMTVLRDLVGDQRFIVALGWCTVVLGIFRMPMGFFPGWLYDVSGNYDTSFIVLGGIELLPVPLLTIDLIRRSRWWRGKANDRREDYERLIGISGDSLGKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXF6</accession>
    <name>A0A914AXF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068815.1">
        <property type="nucleotide sequence ID" value="XM_038212887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212887.1">
        <property type="protein sequence ID" value="XP_038068815.1"/>
        <property type="gene ID" value="LOC119738139"/>
    </dbReference>
    <dbReference type="GeneID" id="119738139"/>
    <dbReference type="OMA" id="DYNDINC"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038001244" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="152" mass="16590" checksum="597CE5FE4147E7E5" modified="2023-02-22" version="1">MANFCILGVFLFAFVVGQTTADCGECPEGWLMFRDFCYKRTGYESYMDAKADCAALGAQLAAPHDADEANFMITMIHPYLWVGCNDIDTEGTFVCCDGTVSTYTNWRAGEPNDAQSNGGEDCGVIYGNGDYNDINCSWSSTGVCKKHVTAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYA4</accession>
    <name>A0A914AYA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038068663.1">
        <property type="nucleotide sequence ID" value="XM_038212735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212735.1">
        <property type="protein sequence ID" value="XP_038068663.1"/>
        <property type="gene ID" value="LOC119738020"/>
    </dbReference>
    <dbReference type="GeneID" id="119738020"/>
    <dbReference type="CTD" id="59342"/>
    <dbReference type="OMA" id="QEPKEVW"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038166494" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="445" mass="49315" checksum="B10F94779B3ADCF7" modified="2023-02-22" version="1">MRTFVVCVSLICIGIALGSRSVSGASTFRGNSIKDTEYWNYVNVRENAYMFWWLYLAQTNPATAPIVIWLQGGPGGSSTGFGNFLEIGPLDVNLKPRNVTWVQTANVLFIDNPVGTGYSYTTSPDAFATNNSQIADDLVTTLTAFYKDHPEFQGNPLYIFSESYGGKMTVGFGQALLKAIKAGKINCKFQGVALGDSWISPVDSVNSWGPYLYSISLLDNKGLQAVNTAAKAVEDAVNQGKFAEATEKWNTCEDVVEDKTDGVNFYNILSTYGERLYERQDNKPHLAPLEKLYRRHVLPFQQGDLNALMNGPIKKKLGIPENVTWGGQSGEVFQKLSVDFMKPVYSVVDSLLDSDLNVTVYSGQLDLIVDTVGTEVWVQKLKWNGLPAFNDKTWAPIQVYADKPAAFVKSYRNFAFYWIMKAGHMVPSDAPGTAYKMMQMVTNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYE3</accession>
    <name>A0A914AYE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038068462.1">
        <property type="nucleotide sequence ID" value="XM_038212534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068544.1">
        <property type="nucleotide sequence ID" value="XM_038212616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212534.1">
        <property type="protein sequence ID" value="XP_038068462.1"/>
        <property type="gene ID" value="LOC119737863"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212616.1">
        <property type="protein sequence ID" value="XP_038068544.1"/>
        <property type="gene ID" value="LOC119737863"/>
    </dbReference>
    <dbReference type="GeneID" id="119737863"/>
    <dbReference type="OMA" id="LANACWW"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF166">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="291" mass="33963" checksum="431981A0A4250800" modified="2023-02-22" version="1">MSGVVEYIKGVAAWAESVADPRTKDWFLIDSPVPSYSLVMLYLLVVWWGPRYMADRKPFDLKYIMMAYNLSLVVLSVYMFKEFFVTTILNPNFNSVCQPVDYSNDPMAVRLAAVCWWFYFSKIIELLDTVIFILRKKNSQISFLHVYHHSTMVLLWWIGVRWVAGGNSYSAGMVNCLIHTLMYSYYFLSALGPRVQPFLWWKKYLTSLQLIQFFGIMIHSFVTLYMDCGFPSPYVYALVAYLISHIILFSNFYRKSYSGKDKKKKTTNGATSEQEQTGARRYNLRQRSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ81</accession>
    <name>A0A914AZ81_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068983.1">
        <property type="nucleotide sequence ID" value="XM_038213055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213055.1">
        <property type="protein sequence ID" value="XP_038068983.1"/>
        <property type="gene ID" value="LOC119738251"/>
    </dbReference>
    <dbReference type="GeneID" id="119738251"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="132" mass="14016" checksum="7205E56371BC4279" modified="2023-02-22" version="1">MADFMIAIYVAVAIAAVGTTIWICNKCRCLYCSNRTIICCLCPPEQVTVPQVYAEIETEMPASVRTAPGNEDATFLTATETKNVDPSAPAEEDKPPTYSEVSQGNQSVGIDPPSPTDASNSQQTADQPAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B102</accession>
    <name>A0A914B102_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069672.1">
        <property type="nucleotide sequence ID" value="XM_038213744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B102"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213744.1">
        <property type="protein sequence ID" value="XP_038069672.1"/>
        <property type="gene ID" value="LOC119738781"/>
    </dbReference>
    <dbReference type="GeneID" id="119738781"/>
    <dbReference type="OrthoDB" id="5875591at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="139"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="27947" checksum="95291D78572E9A2E" modified="2023-02-22" version="1">PVASDGDGPASQAGQTCCQETAAIVGILQGSKGDAGQKGEPGDDGRGLPGKMGPRGFVGPTGETGVKGQKGDIGPRGQRGARGVKGQLGLQGRTGIAGEPGLIGPIGPQGDTGPKGSVGQTGRTGVKGQKGEPGEAPDDSNQRVAFTVVRTSPSDTSTSHTRLPFQATETLLPGTSFDLETGTFTCGVPGTYVFMFSVRKSSSSSNLYVHLRKNGDAVVSGYSTDSSHYEQVSGSAVVVLQRGDTMYITMRGRAYSDSDHRTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1T6</accession>
    <name>A0A914B1T6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069873.1">
        <property type="nucleotide sequence ID" value="XM_038213945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1T6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213945.1">
        <property type="protein sequence ID" value="XP_038069873.1"/>
        <property type="gene ID" value="LOC119739116"/>
    </dbReference>
    <dbReference type="GeneID" id="119739116"/>
    <dbReference type="OMA" id="MHIESTH"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="543" mass="62220" checksum="B0BCA1B4BA807F03" modified="2023-02-22" version="1">MDEQPSTVNNEYDNTSTSNTTDLSNYFDETAWKTWSLIPACAILILFCFLEKRVNLWPTCCHGRPGVAFPVNLVDSYNNRWAFAFAFGSMSTMLIQADGIFPFTANDIDHTNIMLRGTVTFFAILINALVISLVFYPILLCLQTQWKLLGNIFGLLYSIIWFVFYIGSIIVKSLDVGQDDNRCPKEKFLTVLAKLALFGGGATFFLALMICFLVGLTKEFRKGIKLIVLMWLDLFGRQLKFCDKVAVLPEIRKAWPGFNEVVDKREITVWITSVVAVIFTVIHTIDMQLRYRKHTVMLWKGDRSFVPEGKLPFSTTLVASLRYSGYNVAFTMWGFVVMQLLLWVVLSIIILFKDFALILLKQYWLTLVVTFAFYYAQVYISQIVFLQRAPDQQEQSIFSCRRQTSFGLDNRHVFHVTVYILMFVNFILGMLSCFVRISKALLFGTLYIGRLDRLLLMRDWETWDKGYTAYVGFLQLEVAHTHPVLATFCHFLQETVKTDQASSQKYTTNELVSIVNAQIENGYDVPETTNGRCYSPGEPSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2I0</accession>
    <name>A0A914B2I0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_038070004.1">
        <property type="nucleotide sequence ID" value="XM_038214076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2I0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214076.1">
        <property type="protein sequence ID" value="XP_038070004.1"/>
        <property type="gene ID" value="LOC119739224"/>
    </dbReference>
    <dbReference type="GeneID" id="119739224"/>
    <dbReference type="OMA" id="THAEFLW"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="330" mass="36577" checksum="D4CBCEE408182075" modified="2023-02-22" version="1">MSSPKRQKMASLLEQLKQVSTVVADTGDFELINQYKPTDATTNPSLLLAAAKIEKYNHLIEDAVNYGKSNASTLKEQVTATMDKLFVNFGVEILKIVPGRVSTEVDARLSFDIDAQIAKAKKLIALYEDQGIGKERILIKLSSTWEGIQAARQLEKDYGIHCNLTLLFSFAQAVACAEAGVTLISPFVGRILDWYKAKTGKAGYESAEDPGVVSVKKIYNYYKKFGYKTVVMGASFRNIGEITELAGVDNITISPKLLEELKTTNAPLPRKLSPDSAEELTMEKVSLGEQQFRWLHNEDQMAVEKLSDGIRNFAADAIKLENMLKEKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2M3</accession>
    <name>A0A914B2M3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070049.1">
        <property type="nucleotide sequence ID" value="XM_038214121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2M3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214121.1">
        <property type="protein sequence ID" value="XP_038070049.1"/>
        <property type="gene ID" value="LOC119739261"/>
    </dbReference>
    <dbReference type="GeneID" id="119739261"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037893410" evidence="2">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="10768" checksum="021437C32B56CA80" modified="2023-02-22" version="1">MASARLLANLLIGLLIIQACSAATIRNKRSGSRSNSNSRESSEEVAPSGSGFSGAYTDPPSTVAPTTTVAPTTTVAPTTTTTVAPTTTEEIDSSFSSLSSFQPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2Y7</accession>
    <name>A0A914B2Y7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069861.1">
        <property type="nucleotide sequence ID" value="XM_038213933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2Y7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213933.1">
        <property type="protein sequence ID" value="XP_038069861.1"/>
        <property type="gene ID" value="LOC119739101"/>
    </dbReference>
    <dbReference type="GeneID" id="119739101"/>
    <dbReference type="OMA" id="HTDEWIS"/>
    <dbReference type="OrthoDB" id="8951579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="120"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="302"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="554" mass="61487" checksum="ED68127C324CBBA0" modified="2023-02-22" version="1">MSKLSHLTQSSAGLTSPELDAATEMLTRLANRALPGSINDTQADIYLEDFLAIVNNILNPVHTDEWISLQQTSAGTTSVMKSVETFTSSIASHWNRSTLNPFTDVLINKSNILSSMEFIPRDYFSGQSDLVVPQRSGPRWQSLAEKWQSVDDEVAIPEDLITNTPSSMGAMVSFTLYDTLPGMVPITATDRFAKVEGKSLWLNSRILSLGVEPAFEETLDEPILITLTHQTRVIDSKTEKAVCAFWKFDVPHTINGAWDSEGCEVQSTSQTQTVCRCYHLTSFAIIVEPQPLVKLSEDTIILRWLVRCLVGLSVFLLLILIITYIMSKRVHTLRHSIHLNQCLACLIASVAFGLSEFTSDSEVLCLASGAAMHYFYLVVFLWSTMETCQLYRDTTVGGMVTSDAVKGFAVCRNGMGYYMIGGWGIPAVVVGSVLAVSLQAYKPQAYDLCWLVEEDGMPWAYSTPCCAALCVNIFILIMVRRGTDSTVRKLDRTTGFRSSVRATIILNCLYAMTWVVGWKAIYGGPLWTSYLFVILNSLQGFFVFVLQGVCNVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3C2</accession>
    <name>A0A914B3C2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cathepsin X</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038070001.1">
        <property type="nucleotide sequence ID" value="XM_038214073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3C2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214073.1">
        <property type="protein sequence ID" value="XP_038070001.1"/>
        <property type="gene ID" value="LOC119739222"/>
    </dbReference>
    <dbReference type="GeneID" id="119739222"/>
    <dbReference type="OMA" id="FVSGCVC"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000060">
        <property type="entry name" value="Cathepsin Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037172697" description="cathepsin X" evidence="11">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="33696" checksum="C9588978E0A44680" modified="2023-02-22" version="1">MEAKIVTLVIVLSAAVCISAQKYFQPGKPCYRTEMDKKEKGVSTYPRPHWDMKVSDLPKQWDWRNISGVNYASTTRNQHIPQYCGSCWSMGPTSSLADRINILRKGAWPSAYLSPQNVIDCGGAGSCEGGSPIGVYRYAHEKGIPDETCNNYQAKNQNCTPFNECGTCSTFGDCFAYSEKNYTRWMVGDYGPISGRETMMKEIFKNGPISCGIQATPELEKFRGGKVYTQYVPDPEINHAIAVAGWGVDETGIEYWVVRNSWGQPWGEAGWYRTVTSTYKNGMGGQYNLGIENSCSYGDVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4S0</accession>
    <name>A0A914B4S0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070481.1">
        <property type="nucleotide sequence ID" value="XM_038214553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4S0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214553.1">
        <property type="protein sequence ID" value="XP_038070481.1"/>
        <property type="gene ID" value="LOC119739573"/>
    </dbReference>
    <dbReference type="GeneID" id="119739573"/>
    <dbReference type="OMA" id="CEHEPEF"/>
    <dbReference type="OrthoDB" id="10056056at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.9.10:FF:000001">
        <property type="entry name" value="oxytocin-neurophysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF5">
        <property type="entry name" value="ISOTOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001815">
        <property type="entry name" value="Nonapeptide_hormone_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517071" evidence="4">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="62"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001815-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="15505" checksum="5BB4D17676B6D9E0" modified="2023-02-22" version="1">MGMRAAAALWTGVLVALWLHGQACLVQDCPEGGKRSGYNSIRQCLSCGPGGTGQCVGSAICCGDSFGCLMGTKEAYVCQEEIELPTPCEVVGETCEAVADGKCVSNGFCCSSRSCSLDTACRTAETGQRNLKDRLKERLIDALLRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B590</accession>
    <name>A0A914B590_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071411.1">
        <property type="nucleotide sequence ID" value="XM_038215483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B590"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215483.1">
        <property type="protein sequence ID" value="XP_038071411.1"/>
        <property type="gene ID" value="LOC119740239"/>
    </dbReference>
    <dbReference type="GeneID" id="119740239"/>
    <dbReference type="OMA" id="GREFTDM"/>
    <dbReference type="OrthoDB" id="5982901at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029359">
        <property type="entry name" value="FAM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33766:SF1">
        <property type="entry name" value="PROTEIN FAM181A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33766">
        <property type="entry name" value="PROTEIN FAM181B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="48752" checksum="BFB59783E73EEFC4" modified="2023-02-22" version="1">MTQGDQQHPTEMTGAAGSGSSCPEDADAAERGSSSPQEERDRIAMEDRLHHAHQHHFTHHHQQPPEQTTAADGDVKTLLHFVSLASSDIKAALDKSAPSNARKSSSVDNINRKFPQKQLLKKSPISNFTGSEVYRGDDPYFNSRRFAASLNSPQSPGIQSGALHFSERLMASASLHRDHLIKNSDLLKELTFGSGIRRDLDQPLFGRRGSTRYHDHRRSAGLSGREFTDMAKLDRSGEAERPDSDNPLPLRKRRLPASFWQEPDRSENHKTIPSTITGLSPVNLSSNLKFPNLLPSLAQGFTDSRPTSLDKNAIYPSGDQCYSGLNLPFPPPLSNSLNRDNYLNRALNFQYSSICSCSQHTELYSYEHGPACAAYAARHGGETPGIFNPISATGLLSRWHVPSQLTTERAGMCHPSAPRVVKPIPTKSITSYPPRYHPIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B758</accession>
    <name>A0A914B758_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071794.1">
        <property type="nucleotide sequence ID" value="XM_038215866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B758"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215866.1">
        <property type="protein sequence ID" value="XP_038071794.1"/>
        <property type="gene ID" value="LOC119740525"/>
    </dbReference>
    <dbReference type="GeneID" id="119740525"/>
    <dbReference type="CTD" id="5700"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="49593" checksum="143E60C04EE03144" modified="2023-02-22" version="1">MGQNQSGGPGGGHGDKKDDKDKKKKYEPPVPTRVGKRRRKTKGPDSANKLPKVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQERLKPQEEKDEEERSKVDDLRGTPMSVGSLEEIIDDNHAIVSASVGSEYYVSILSFVDKDQLEPGCTVLLNHKVLAIVGVLSDDTDPMVSVMKLEKAPQESYADIGGLDQQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYESNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFNIHTSRMTLSTDVNLDEYIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFRKSKENVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7G3</accession>
    <name>A0A914B7G3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine</text>
            <dbReference type="Rhea" id="RHEA:20273"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="EC" id="1.14.16.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038071750.1">
        <property type="nucleotide sequence ID" value="XM_038215822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7G3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215822.1">
        <property type="protein sequence ID" value="XP_038071750.1"/>
        <property type="gene ID" value="LOC119740502"/>
    </dbReference>
    <dbReference type="GeneID" id="119740502"/>
    <dbReference type="OMA" id="FHDEVYR"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046189">
        <property type="term" value="P:phenol-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04904">
        <property type="entry name" value="ACT_AAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005961">
        <property type="entry name" value="Phe-4-hydroxylase_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01268">
        <property type="entry name" value="Phe4hydrox_tetr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="15">
        <location>
            <begin position="111"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="457" mass="51933" checksum="B3A6EDA5985A228A" modified="2023-02-22" version="1">MDGGKAAKKRRVESNNGSEKQAAGGQQTGDNGGNNNTSLMFGLKEEVGILARTLKLFEEHDINLSQIESRPSKRVEGNYEFLVLCDEKADKLDAVLDKLKEKAKYVHVLSRSQDENTSSVDKIPWFPRRIRDTDDFANNIMSYGSELDADHPGFTDDVYRARRKEFADIAFHYKYHTPIPRVTYTEEEIKTWGNIFREVSKLFPTHACREFNHIYPLLVENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLAPRDFLAGLAFRVFHSTQYIRHGSKPWYTPEPDVCHELIGHVPLFADPSFAAFSQEMGLASLGAPDEYIKKLSTLYWFTVEFGMCIQNGHKKAYGAGLLSSREELKYCLTDEPATRPFDPAVTAEQEYPITSLQPIYFVAESFEDAKDKMRKYAASIPRPFSVRYNPFTQTIEVLDKKMQLKDLATSIRGDLNILIDAVNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7N0</accession>
    <name>A0A914B7N0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038072183.1">
        <property type="nucleotide sequence ID" value="XM_038216255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7N0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216255.1">
        <property type="protein sequence ID" value="XP_038072183.1"/>
        <property type="gene ID" value="LOC119740818"/>
    </dbReference>
    <dbReference type="GeneID" id="119740818"/>
    <dbReference type="OMA" id="YAWLRIN"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="670" mass="75333" checksum="0C41A0FF9A4DA9F2" modified="2023-02-22" version="1">MSGFPINRRALGAAAVTLAGLPVAAAGFLRLKYGPTVFADLVARRQLFRLFKQLEALEKKNFKIIDFFEAHARETPGKEFVLYKDEVHTYGDLDRQANQLAHLIQRSAVAAPMDTVAIFMLNEPSFVLSWLAFNKLGLRIAPLNYNLKGNSLLHCIKACNVKLIACGKGRLVQVPLSSSINPTLQYISNVILNHQRKKNAFIADESLLEALEDLMPELQTLGIKVWVIGRNITHNLPFGMIPVDVMALDERTDPIPRSVRDQQPNGDDALYIFTSGTTGLPKPAKFPHYRQVRSSFMQISLMGKDDVLYTTLPMYHSAGLIIGFLNILRAGGSIVLSDFSAHRFWDDLRKFRATIFQYIGETCRYLMAKPRRIDDGKYSHTINYAIGNGLRPDIWEAFQKRFNIGRIIEFYGATEAPFASLNMDGKVGSVGRYHGIQQALDDVVIIVQCNVETAQPLRGPDGLCIITPPGETGLMLFRLTDKLIFHGYLAKKSDQQKKIVRNVKKNGDRFFNTGDLMIHDKDGYLYFMDRLGDTFRWKGENVATTDVAHVLNLYTGIQESNVYGVQVPGQDGRAGMAAIVIIKERPLDPKAFYDHVVRSLPLYACPKFLRIMSEMQITGTFKHKKTDLAREGFDPNVISDPLFFMDTDKKTYAPLDNDAMKKIVIGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7N8</accession>
    <name>A0A914B7N8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071820.1">
        <property type="nucleotide sequence ID" value="XM_038215892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7N8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215892.1">
        <property type="protein sequence ID" value="XP_038071820.1"/>
        <property type="gene ID" value="LOC119740547"/>
    </dbReference>
    <dbReference type="GeneID" id="119740547"/>
    <dbReference type="OMA" id="FANTYLW"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038114280" description="Saposin B-type domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15912" checksum="43BBDF46221C7174" modified="2023-02-22" version="1">MDKSVGILVIMFIVAVSGQEYDLTMNDEYVVEQHQTPSSNEVARMIKRLAIGIQRIQMLSTEDRDDKLFCVVCEEMMTLLYSVSTDKELLDLLQKVERQVACTYLFSEGFKSYCEDFVDDIEIPDLLKAFANTYLWAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7R7</accession>
    <name>A0A914B7R7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Adhesion G protein-coupled receptor E2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072218.1">
        <property type="nucleotide sequence ID" value="XM_038216290.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216290.1">
        <property type="protein sequence ID" value="XP_038072218.1"/>
        <property type="gene ID" value="LOC119740840"/>
    </dbReference>
    <dbReference type="GeneID" id="119740840"/>
    <dbReference type="OMA" id="NISRITC"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1078"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1193"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1271"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="460"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="16">
        <location>
            <begin position="870"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1320"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1360" mass="148007" checksum="9F672457D156F9BE" modified="2023-02-22" version="1">MNFDDCSSDPCFNDGSCTDDINGFICHCPEGFEGNVCLINIDDCSPHSCLNDATCVDGINDFTCECADGFEGPDCATNIDDCSPNPCMNNGTCTDGINGFTCECLTGYERDMCTSDIDDCEPDPCLNGGTCSDGVDSYICTCTPGYTDSRCSSDVNECEDLSSCPPANRPCINSIGGFACTCPSGYEWNSTQCIDVDECLADDAPCPDTVPCRNTEGSFTCLCNQGFAWDGGSCSDVDECLDAPCSNTATCVNQPGGYSCVCPAGYLWNGTSCDDIDECEQESSVCPSTSPCKNTIGSYTCICSEGYGWNGTRCTDVDECQSSEPVCPSLASCTNTHGSFRCHCQDGYTLTRQPGSSLFFCLDIDECQDEALYDCHSNAACINEPGAYRCMCSETQGYRGDGTVCTPFDLCESGPCLNQGQCTSSVGSGSYECVCTDDFTGVNCGIRVVPQGPISVLKHPEPSLITASLYDTVTLECQFENANRFAWYRNGAVLPGTRDVSFLTIAGVTLTDRGYYWCEGSGLQGVTLQTNASLLLIDGVFAFTTGARFPTLTFVDELRNKSSPIFKQISAEIITFLSEGLQSEGVQANITVKELNSGSVLATTEILTNAGGTNSDDSELLSIVQDALVGKATASDGYMDPSSITLESSGSCVETRWPTIYDTITLPAVPLGEDTVSNSDHVCPDYTINSGQPIAYAVCVGDGFSPAQWLVELQCGRNLTVDEKLALLNRVEVNDENVMVVALQVMALTEDVEMLSDAGVASIADIMTKIADVNSSTSQVTTTVVDTVGNLMFISDEVLREAEVREHAPSRIVRVLEQQLGKVSLAGNVSFREVHPNIAVEVRGVTESTLLNGLGFASANSSSSGLFGESSLMVMEGGDQLFQGALESEMPSAVLMLPPEVSILARRDEVGGGIRVSFFVFRKLNLFQSPLLADFNKVEDRFNRTINTRVMSATVGSQPITNLNEPVTILLSRIDNDSYVDNTSCVFWEFDNASWSSEGCRLREEYITDQYIACQCDHLTNFAALMDIYPESPLTETQEFILKLLSLVGCGMSILGLAVTMVTYLSHKKLRKNRPNRILLSLCASLLCLYITFVVATALDSERGVAELDVLPCCVLAGFLHYFTLTSLCWMGVEGLNMYLLFVRVVNVYVPKFMLKASLAAWGIPALIVAITAGATREDYVGTDFCFLKQIPLIAGLLAPIGLILLFNIVVFRLVIRQFIKTSNNDLRRNRDEMSKRKLHKQRLQNAMTVMTLMGLTWSIGYLNLVQAISFPVQLVFCLLNTLQGYFIFMLYGVRRAEVRQHWRRCCVFQRATFSSVRTSSQTQSSTIKPQARTPFNPNMIPRPPSEIYRHRPDSMMPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B821</accession>
    <name>A0A914B821_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071582.1">
        <property type="nucleotide sequence ID" value="XM_038215654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B821"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215654.1">
        <property type="protein sequence ID" value="XP_038071582.1"/>
        <property type="gene ID" value="LOC119740379"/>
    </dbReference>
    <dbReference type="GeneID" id="119740379"/>
    <dbReference type="OMA" id="DSIMTNI"/>
    <dbReference type="OrthoDB" id="6343173at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037227060" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="156"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="290" mass="29947" checksum="ED54625A75E4FB76" modified="2023-02-22" version="1">MALTVRREHSVLPMIVMLLISSSHCQRDSETTGQPTGSSSCCSACLPGHPGVPGIPGNPGGIGVQGPKGDPVYGLPGPKGEIGEQGRKGDQGEPGVEGPLGKLGPAGRKGDIGEGQKGDQGEPGLEGPQGPAGPQGPAGETGQRGQPGEATLVTPTAPSAVAFSAYRTSRVTGSTGDVIIFDSIMTNIGDRYDSQSGVFTCAQPGVYFFTTSFLSINSATRPLVKLKKNGDLIFSIYDNHNSYHHQSSNSAVLILATGDRVWLEFGSGGTGIFSNADRYAYFSGFLIHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B887</accession>
    <name>A0A914B887_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072199.1">
        <property type="nucleotide sequence ID" value="XM_038216271.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072200.1">
        <property type="nucleotide sequence ID" value="XM_038216272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072201.1">
        <property type="nucleotide sequence ID" value="XM_038216273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072202.1">
        <property type="nucleotide sequence ID" value="XM_038216274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B887"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216271.1">
        <property type="protein sequence ID" value="XP_038072199.1"/>
        <property type="gene ID" value="LOC119740829"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216272.1">
        <property type="protein sequence ID" value="XP_038072200.1"/>
        <property type="gene ID" value="LOC119740829"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216273.1">
        <property type="protein sequence ID" value="XP_038072201.1"/>
        <property type="gene ID" value="LOC119740829"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216274.1">
        <property type="protein sequence ID" value="XP_038072202.1"/>
        <property type="gene ID" value="LOC119740829"/>
    </dbReference>
    <dbReference type="GeneID" id="119740829"/>
    <dbReference type="OMA" id="WMILISK"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="223"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="433" mass="46041" checksum="8458A1EE24DA2778" modified="2023-02-22" version="1">MNSLCSSWRWMILLSKASLSFFALGLFKAMGVFIPYLVDDLGASVAAIGTATGIYGSLCSVLAPLASALTPYGPRRLVIIGGAVMAIGTMGAAASTNSLHLTLWLALSSTGGSFVNVSAFKPLMDYFPESFATVNGISFAAGTVGMMALPPIAEWLIGLYGWRAALFLLGTATFNVCVFGALLRPCSAKSCSSTRYQKLHHEDEVSAAEKVRDDDGAVGAISRKCEACNGFLLERFDPKMFITEPRFSLFQLPSFVMGAVYSGWQLFLVPHSVALGYDSQTSSFLSTFGGLGSLVGRLTSGFLTDRDLIKPMDLFILACLLCGVSCLIDPLAVSSLPALAGLATAVGLAIGYTYPLTFVITRDLVGEDERQMAALGWLYLFAGAGQIFGGTISGWTYDVTSDYEIVFMMYGGLSLLVIPVMLAIRFTGVCCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8S7</accession>
    <name>A0A914B8S7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071817.1">
        <property type="nucleotide sequence ID" value="XM_038215889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8S7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215889.1">
        <property type="protein sequence ID" value="XP_038071817.1"/>
        <property type="gene ID" value="LOC119740544"/>
    </dbReference>
    <dbReference type="GeneID" id="119740544"/>
    <dbReference type="OMA" id="WVINICI"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF148">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="90"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="262"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="312" mass="33847" checksum="D108FFD73CEBEFA1" modified="2023-02-22" version="1">MYGHNVGTLNVYTETNGVLGSARWSQSGYTKESKWYEASISIDPGSEFKLVFISENAVGSQGNIAIDDISLSDGVCSALPPNTPDPSFLVDCDFDDAIHLCHYTNSKNDDGDWYRDSGSMNGVSIGPRSDHTTGNSSGYYLHTPDYGSNKPHLEGVTVVAPASGACITFWYHMYGYNIGTLNVYTETNGVLGSARWSQSGYTTESKWYEVSISIDPGSEFKLVFISENAVGSQGNVAIDDISLSDGVCSALPPNTPDPFFLVDCDFDDAIHLCHYTNSKNDDGDWYRESGSMNGVSIGPRSDHTTGNYKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9F1</accession>
    <name>A0A914B9F1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 3, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class O protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072067.1">
        <property type="nucleotide sequence ID" value="XM_038216139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9F1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216139.1">
        <property type="protein sequence ID" value="XP_038072067.1"/>
        <property type="gene ID" value="LOC119740736"/>
    </dbReference>
    <dbReference type="GeneID" id="119740736"/>
    <dbReference type="CTD" id="84720"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000041">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="854"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="972"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="938"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124980" checksum="EA48DF28ECAD287D" modified="2023-02-22" version="1">MSIGTKLFMLLIWIGTLFGIGIMIFSRGFLLNRLEIQQKSYCTGDSDHSGESIEGARQSCGEHRRYSKAIIIVIDALRYDFTLYNETLDNKSALPFQNKLPFLHKLRSEKPQHSLLYEFIADPPTTTMQRLKGLTTGSLPTFVDAGSNFASAEITEDSFIHQLHRLGKRITFMGDNTWESLFKGQFSRSFPFPSFNVKDLHTVDNGVIEHLVPEMAEQDWDLIVAHFLGVDHCGHRFGPFHSAMGEKLLQMDQVLRSVVERLDDDTVLFVLGDHGMTRTGDHGGDSREEVAAALFVYSHSILHQETPDMKSVQVASQIDLVPTLSLLLGVPVPFSNLGSIIPELFTLTPFSNQPSSPAIKNWPLHVQSVYNKVGALRTNAHQVNHYLQAYSKISDEFPRAQFALLQDFFQDAETAVKEVLQSSANDEIRSYALLQRSEQVYLQYLNRVKEMCRSMWARFDLTLIILGLAIVVGTCLTSYVLLTHNQNFGNRVLLDSALGTLLKIIAVTIIACLLIGLIISFTIPGLQAHSAILVLTIPAVGSLLNAVVWIAFVSTEMKISYLFKFLTYSIKTVMAVILTLTYAACLTSNSFVINEGYVAAFLTHSLHLVCMCSVGSIFIQSKSSKETTRKKTKTEKSRDIGHFLTNPGTVFALLVFAFHLCVRFSSLFLACREEQNPCQQSELLRPLGTFSDDTGSYRNYRYLMSVASLAFIPASLTFWLNKQGNLNGGAAPVFSVVYALPIATVCICLNWGLQALPQKVLDNLPAWQQVLMPRLAYVMLFVAFITILWNPLCIYLVPREETKKKIQVDYPGEGESVVPKLFNHLKTTWKRNTRQGKLASDDSQDEIRETSPPVVYGLATVFSACWLLLSASVALLIALLLGDGLAPAVLTMILQMIIYLELYAIIRRQQLAPLEVVPDLHHLGMYQVPWYAIATWGFMSSQFFFATGHHATISSIRFDSAFTGFHGDFPPYLYFIPGALITINTFASQIVFAVALPLLLIWPFTRGKMIDRKKDEDRKGELGLHVSNRELRIAFFQIILAYILYNATQLVGAMVSAAIHRRHLMVWKIFAPRFVFQGVSFMVVMVILILLYLLLVKIDRAVSNWLQVLFQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA38</accession>
    <name>A0A914BA38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072961.1">
        <property type="nucleotide sequence ID" value="XM_038217033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217033.1">
        <property type="protein sequence ID" value="XP_038072961.1"/>
        <property type="gene ID" value="LOC119741279"/>
    </dbReference>
    <dbReference type="GeneID" id="119741279"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037710674" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="170" mass="18582" checksum="C928E188D4FFC9D2" modified="2023-02-22" version="1">MESLVVLLLVCFGVASCAVCGPDRELFEKASYCMVDSHIPWVSATTACSSMGGRLAVPNSQAEQAFLYDFAAQHFGIYSSIWIDCSKTSTHGQWMHADGSPCEYTNFIYGDVDGANCVHMYLNSGYWFAVDCSANIFPVVCELPLPEGSSEEVKPSMFCMEFGADGRLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAR5</accession>
    <name>A0A914BAR5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073288.1">
        <property type="nucleotide sequence ID" value="XM_038217360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAR5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217360.1">
        <property type="protein sequence ID" value="XP_038073288.1"/>
        <property type="gene ID" value="LOC119741560"/>
    </dbReference>
    <dbReference type="GeneID" id="119741560"/>
    <dbReference type="CTD" id="55676"/>
    <dbReference type="OMA" id="WCQSTNS"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052005">
        <property type="entry name" value="CDF_SLC30A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46531:SF1">
        <property type="entry name" value="ZINC TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="591" mass="64833" checksum="E30B6413B92C90A9" modified="2023-02-22" version="1">MAAPTSARTEVSTLEAENDHFRERYAPKMAQTGTRFYQRPDSSNFTQPLKRDAFKIDIDAYDTSMDIAPTSSSSTSDLRQRAVLNGGTKDHITGPIQPFARPQQGVISKLMQEFWSVIGEKEARRVVILGIFDIACMLVLLLWCQSTNSMALSAYTYLTVCDLMLLVTCLITVWVSQQKPVSVYSFGFERFEVLSVFSCTMLAIFGAIFIMKESTERLFQPVDIHTGRLMLGAGLGLICHITVTYGANSKAFRHVIEASRSSWLQEHFADMSRNFCAIVPGFDRLLLPRVNPFVLIAMAGALSLLITDLLVDVNNYFVADTLAAICIALMTFGTMLPMSIYTGTILLQTSPTHIIGQLDKSLREASTLDGVLEFRNEHFWTVSFGAIAGSLHVRVRRDANEQMVLAHVANKLSHLVSTLTIQVIKDDWTRLTPLSSFPGEALSSKLPPPAPLNPNFVASNPGLNVYSAAATLQQQKKGLYDFQIPTTPSRASSTPYGTPSRDLSFHSGIGPISTHGESTSPMLDRYNADTQLKGILRTGGMGPRGLPPNMANSRPLASSHSAVIDLNSLGTANLYTPGKILADHNHLNFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDQ4</accession>
    <name>A0A914BDQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074125.1">
        <property type="nucleotide sequence ID" value="XM_038218197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074126.1">
        <property type="nucleotide sequence ID" value="XM_038218198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218197.1">
        <property type="protein sequence ID" value="XP_038074125.1"/>
        <property type="gene ID" value="LOC119742158"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218198.1">
        <property type="protein sequence ID" value="XP_038074126.1"/>
        <property type="gene ID" value="LOC119742158"/>
    </dbReference>
    <dbReference type="GeneID" id="119742158"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34373" checksum="642B9A580C93044E" modified="2023-02-22" version="1">MDEEVITAIRYAVSVCSILAIVANSIVITVFAVTKQLRNKYYAFIFNLALADGLFAAFNIAVPWTDKSSASDVWAGLVIASFTVSVLTILAAAINRYLALSLTPPARYDALVTGYRLAGVCAILWVCSILYGFLIRNVAASGVYHVIQHLVYSLVLVVIWFITAIAYFLAFRKVKQYTPPLASTPGISVNADCDDDTRARQTRRLLVIFTCVLLMSFISWVPYGMLWMVVYFNTSLLYNAHFLAFFWGIYFMYCLSTVINPLIYWCGLNAFREGFYAVFCRCVVKSDNGRTDIEPITNENTVVDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDV2</accession>
    <name>A0A914BDV2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073612.1">
        <property type="nucleotide sequence ID" value="XM_038217684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217684.1">
        <property type="protein sequence ID" value="XP_038073612.1"/>
        <property type="gene ID" value="LOC119741789"/>
    </dbReference>
    <dbReference type="GeneID" id="119741789"/>
    <dbReference type="OMA" id="SWIKATR"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="21093" checksum="80A8DBCCA20EB6CA" modified="2023-02-22" version="1">MASDAKQSRVMLWTCPRSCSTAVQRSISHVEGGVFYYEPYTMAFHFGPDRKFQCEANRDERGELPSSYLTYDSSVNTFDWVKQTLEAKHQGASLVFAKDLAFCLGGTTNLPSGYRHSFLIRNPKKVIPSWRESQNDLKTEFTMEVAEEFKDVVMANSAGFKELFELFKYIQENVDPNPLWTPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF62</accession>
    <name>A0A914BF62_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074072.1">
        <property type="nucleotide sequence ID" value="XM_038218144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF62"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218144.1">
        <property type="protein sequence ID" value="XP_038074072.1"/>
        <property type="gene ID" value="LOC119742108"/>
    </dbReference>
    <dbReference type="GeneID" id="119742108"/>
    <dbReference type="OMA" id="ENNIRTH"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="298" mass="33939" checksum="57282363F38A0ABB" modified="2023-02-22" version="1">MDIQGTELICHPSVHTSEKQFICETCGKALTRKRDLQRHNRIHTGEKPFLCAICGKGFTTNRDLQRHNRIHTDEKPFGCEICGKAFSVQSNLRRHEMKHAGDKPFVCDTCGEAFTTEGRLQRHDRLHTGDKAFVCETCGEAFTTEGSLQRHGRTHTGNKPFVCETCGKAFSTQSHLRQHEMIHTGEKPFDCATCGKAFTRQSDLRCHEMIHTGEKPFPCATCDKAFARLSSLYRHEWIHTGEKPFVCETCGKAFTRKSHLCAHDMIHTGEKPFVCATCNKGFTRQTYLHKHYRIHTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG74</accession>
    <name>A0A914BG74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075258.1">
        <property type="nucleotide sequence ID" value="XM_038219330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219330.1">
        <property type="protein sequence ID" value="XP_038075258.1"/>
        <property type="gene ID" value="LOC119743022"/>
    </dbReference>
    <dbReference type="GeneID" id="119743022"/>
    <dbReference type="OMA" id="PAMVANH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF284">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28410" checksum="57899BC6C6D745EC" modified="2023-02-22" version="1">MKSNMSLPRLEDEDDLNVWERYVQPVFAEFTGSILYTFIACLAVSANNVFAIGIAHGFGIAVLCTAFVRISGGQFNPAVTLASLLSGGTGIVGLVYLPFQFIGALLGSAFVKASIYQYNSFEEIHGGANMMRGNRRIDPFNEYQRTSTWQINIVSIIIIEIVASTAVYLCYLLNNIDDRQPQRAPLYYGMGVAAAVISTYFTSGGGFNPAVSFAAAITSGYWNEHYVYWVGPLIGALLAALVYRLILGDRRKRLLGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGA0</accession>
    <name>A0A914BGA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proton-coupled folate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074931.1">
        <property type="nucleotide sequence ID" value="XM_038219003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219003.1">
        <property type="protein sequence ID" value="XP_038074931.1"/>
        <property type="gene ID" value="LOC119742819"/>
    </dbReference>
    <dbReference type="GeneID" id="119742819"/>
    <dbReference type="OMA" id="SIITYMW"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54725" checksum="4B2F65C2E852DC92" modified="2023-02-22" version="1">MEVLQRVTVEPIRFIFTMALAMQYRATRALILRKVCISSHNQTLCGIDEDSSGLDSDMPDGQTVRDDVATWCFYLDACANLLGALVSCVYGSASDRFGRRGLLVLPSLGLMLGSASYFIHYYFLQLPLYYVFFSSALMGLFGYYQASYIATMSYICDITDHSDRSFRLGVMESMGLIGGPVGMMLASALLYVNYDGLVYFIIILSQGVVLLYVRYWLQETIDVRAFQEVNSQDANCSPQKICSDVSWSLKRTLMVYVIWRTENRRQLLLINQTVGILSSLGSSGEMDLTRLYTSSPPLSWADSTLLAYLSVKDAVKGMILAVGIPLLFLYFSHWTIRLDMIIAMTTLLSTSASLVLRAFASSTLMMMLVPVVGCLGGFPNTLISSIKCKLVDPDEFGALFACTMLIQSICHVVGRVFFQMLYAATLTIWPRLPFLGMGIFFVMLLSIITYMWCLSGHLDKKDKTDARQQLINSYDGNEEEIELFSAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJC5</accession>
    <name>A0A914BJC5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076383.1">
        <property type="nucleotide sequence ID" value="XM_038220455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220455.1">
        <property type="protein sequence ID" value="XP_038076383.1"/>
        <property type="gene ID" value="LOC119744508"/>
    </dbReference>
    <dbReference type="GeneID" id="119744508"/>
    <dbReference type="OMA" id="VADNHTE"/>
    <dbReference type="OrthoDB" id="10394664at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="189" mass="20616" checksum="4CDB643B0A62AE8B" modified="2023-02-22" version="1">MNENFSDRAEHLIAITRMEAQLNFRRIISGSYYLCLMAALSVLVADNHTEALPAGARRAACRGLPAGLQSDTADEVVGVTAEGQIHTQRFELNSYTPGQHVIVSVLEDSPDKDAHSRPWVRQYALQTIGGVTGQTFGRFKALTDATKLHHCGTLTILRDENQGNNGVAFAWLPPHEGDVQPVTIIVAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMM9</accession>
    <name>A0A914BMM9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077374.1">
        <property type="nucleotide sequence ID" value="XM_038221446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221446.1">
        <property type="protein sequence ID" value="XP_038077374.1"/>
        <property type="gene ID" value="LOC119745222"/>
    </dbReference>
    <dbReference type="GeneID" id="119745222"/>
    <dbReference type="OMA" id="FIHEYDV"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 17" id="KW-0420">Kringle</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 20" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15 20" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="22">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="371"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125821" checksum="7AA6701525CA8F53" modified="2023-02-22" version="1">MGMCIPLRKKCDRRPDCYEGEDEDDCECKKSEFRCKRRGGCIAKTRVCDGRADCFDKSDESVEICGVSNRTFPDCTSSSFFMCPSKAGCIPWKFVCDKFADCLDGSDEEPISICVDNRLEILQPVYLSPTCSPGEFMCKSGECIQEGWACDGSLDCRDGSDEALKLCGRPLCTPPQIPCPAGGCGTLCDLNPECFNGWDETNCTCQVLDEETVIEEIKCKNASSTKYFKGAEYPYLTVCATATPFYRCDGGLECFNTTSKLPEHCKTVYSECYIATNGWDYRGTKTQDDCLPWSDPRVALLNYTGQNFRELEGVKPGSTVGHSLCRNPGGERDTIWCFVDSGNGSLEYKNCTPLPPPIPLRKSCHDELFSVALSQDDSSSDPTQGRVEVSFKTGAVGTISDPDWTLEDANVVCRQLGFPAGAIVNSTIDFGPGTGRVLLRDVQCMGIEVNLIDCLYRLASDQDTNHTYDVGVVCNDTDAVPRRQKRGVAPTSDLISDACPFCSKKRLNSEPSPDTTSPCKHEEFQCTERKPNAPIKCIPREYVCDRYNDCSDNGGLLKPGMPMDSDEQHCTLSAGDCGNGNFKCRSGECIRYWQTCNNFPDCQDGSDEMLPECEVRRSACRLQEFQCTEPLSDGTYKCIPRNFVCDRYNDCGDNRGPLTATITRASDERACIKPGEVPPDNYYRCRDGMEFIHEYDVCNTVKDCKQGDDEENCYLAGRSDPFGGLFQDPKWYFPYLVMVSKEHRSHLFDNFMEDFRAPPFGRVKGDYPPDWNGFVTFSSTPDYSDLVGVAKMSKDEVSRYGHQKDDFILQCTYEQRKCNMSNFQLLQDDNYGNCFTFNAAIDNPITAKKTGSRYGLQMTLFLEQSEYISIFGPEAGVRVCINPQHIRPNPTDTGMTVKPGTVTSLGLRYNDVLRKGFPYGKCLKKVRNTKIIADGEIKISSLDYYDRELCKKTCIHEHIRKYCGCSDTLELNGERCSLLNKTQEVCVQLVYYLSQHNNLTCSCPQQCSEVYYTKTSSMSKWPSQKFAKHLLRNIHSINEKTLHLNEENLFDNIVRLEIYYEELNYESTKEVPAYQEASLFGDLGGIVGLYIGFSLITVCEFIALFLKLIKKSCCNRTVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNP0</accession>
    <name>A0A914BNP0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uracil phosphoribosyltransferase homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077570.1">
        <property type="nucleotide sequence ID" value="XM_038221642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNP0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221642.1">
        <property type="protein sequence ID" value="XP_038077570.1"/>
        <property type="gene ID" value="LOC119745347"/>
    </dbReference>
    <dbReference type="GeneID" id="119745347"/>
    <dbReference type="CTD" id="139596"/>
    <dbReference type="OMA" id="NLFCTPM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000026">
        <property type="entry name" value="Uracil phosphoribosyltransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="232" mass="25873" checksum="B7E09BD5099A4E2D" modified="2023-02-22" version="1">MGADDDTCKMGEAGKVKKFGSNSVEMDEFGPQLKLLKANDQIRELQTIIRNKATSRGDFVFYADRLIRLVVEEGLNQLPYTNAVVTTPTGCKYDGVQFEHGNCGVSIMRSGEAMEHGLRDCCRSIRIGKILIRSDDDTNEAKVFYAKFPPDIHKRRVLLMYPILSSGNTVIQAVRVLAEHGVKENMIVLLTIFCTPNGVRSVINKYSGIKILTSEVHPVTPNHFGQKYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP05</accession>
    <name>A0A914BP05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077690.1">
        <property type="nucleotide sequence ID" value="XM_038221762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221762.1">
        <property type="protein sequence ID" value="XP_038077690.1"/>
        <property type="gene ID" value="LOC119745426"/>
    </dbReference>
    <dbReference type="GeneID" id="119745426"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="50143" checksum="C42F337BB12DC5FE" modified="2023-02-22" version="1">MRECISIHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTVGKELIDQVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQISTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGSLNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLTVAEITNSCFEPANQMVKCDPRHGKYMACCLLFRGDVVPKDVNASIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSADGGEEDEGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPB4</accession>
    <name>A0A914BPB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Max-like protein X</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Max-like bHLHZip protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein BigMax</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Transcription factor-like protein 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAD1, MAD4, MNT, WBSCR14 and MLXIP. Can also bind DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078118.1">
        <property type="nucleotide sequence ID" value="XM_038222190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222190.1">
        <property type="protein sequence ID" value="XP_038078118.1"/>
        <property type="gene ID" value="LOC119745665"/>
    </dbReference>
    <dbReference type="GeneID" id="119745665"/>
    <dbReference type="CTD" id="6945"/>
    <dbReference type="OMA" id="TSAMGCK"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19687">
        <property type="entry name" value="bHLHzip_Mlx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000037">
        <property type="entry name" value="max-like protein X isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF25">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="19">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="26508" checksum="F535DE8A28EAD81A" modified="2023-02-22" version="1">MSATDSSFADSSFDQSMQDDDLPLSGPTSRQNSASSLPGLNDGGLQLTDDDDDTSDAFRNYKDRRRNAHTAAEQKRRDAIKKGYEELQMIVPTCQQVDSVGSQKLSKATILQRSIDYIQYLVQQKKKQEQEVENLRKEVMALKIMKSNYEQIVKAHQNTPGQGQNQVSDQVKFNVFRAIMDSQFQSFNESISVASFAELSACVFSWLEEYCKPQTLRELVFNVLRKLHQNQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPK6</accession>
    <name>A0A914BPK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2 J1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">E2 ubiquitin-conjugating enzyme J1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Non-canonical ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. Interacts with E3 ligase RNF26. Interacts with E3 ligase RNF133.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078208.1">
        <property type="nucleotide sequence ID" value="XM_038222280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222280.1">
        <property type="protein sequence ID" value="XP_038078208.1"/>
        <property type="gene ID" value="LOC119745732"/>
    </dbReference>
    <dbReference type="GeneID" id="119745732"/>
    <dbReference type="CTD" id="51465"/>
    <dbReference type="OMA" id="IYHGALI"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000043">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="389" mass="42562" checksum="31C603B0FC1ADA2A" modified="2023-02-22" version="1">MQGQYSRRSPAVKRLMKEAQELSDPTEQCYAQPLEDNLFEWHFTVRGPPDSDFQGGVYHGRITLPPDYPMKPPSIMLLTPTGRFEVGTKICLSISGHHPETWQPSWSIRTVMLAIIGFMPTKGEGAIGSLDYTPEERKILAKKSQEWTCPSCKKANKTILPKETSSEKSKEMQREAAKLASQISFKKEDDKKKGESTSSNPAADTSQPQTNAIPAAANPALPPNPFAAFNPAAMGMNFQPGMFHGYPPNFMNVNQQVPANQNAANPPAGTQGTNQMPSNVTQPPAGQSESSQATTSQSQNPQPQAAATSQPSTTTTTPELRQRAAAAATPGVNQTQPRTDPQRNQVANEDNSGGRWAIVIMIIITIIMLFLLGRRLFITYEYKFQSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPK8</accession>
    <name>A0A914BPK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078074.1">
        <property type="nucleotide sequence ID" value="XM_038222146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222146.1">
        <property type="protein sequence ID" value="XP_038078074.1"/>
        <property type="gene ID" value="LOC119745641"/>
    </dbReference>
    <dbReference type="GeneID" id="119745641"/>
    <dbReference type="OMA" id="ELAPTTH"/>
    <dbReference type="OrthoDB" id="6884957at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="87"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="583" mass="64940" checksum="520841D7428A6798" modified="2023-02-22" version="1">MKVEDIIPLLGNFGRYQLFVVLYTGVLSIVGCMVSFGNVFFAAETDHWCQVLPKENCSSWAEFQDNCTDVKKSILLPPPENENSKYPYSTCQQWDLPPGYEFDPYEPLSEVDNHTYKVPCQDGWQYDTSQYKTTTISDFDLVCDKRSLPSLAQSIYFAGFLVGSFVCGSLSDWIGRKKTVFVGVLFFAVGSIVTTFSVNIYMYMAFRFIAGFGNIGSYIPLFVLQLEFVGKSWRTPVAMSSGIFFAFGYFVLAVAAMYVSEWRTLSLIVSLPTLLFFIPILFMQESVSWLISKGRIEEAEAVIRRVAKINKKTLPDVLLNKDDIEQETESKESRVPPSVIDLFKTPNMAVKTINMMYNWLVNSLIYYGLSQSTGDLGVDEYWAFFISGAVEIPALLYATVGVEWFGRKWNTAVLEVIGGVACLATIFIPLGIWRTVVSMAGKFCISATYGIIYLYTTELFPTPVRSIGLGMSSLAARIGGILSPIILLLGDYLESLPLIVFGSSAVLAGLLVLLLPETKGRKLPQTLEEGEEIGKCRCMRKNADTVAITGLDEIEADKEGALTNPAFDNKLEDEEEKTIQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRQ2</accession>
    <name>A0A914BRQ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078844.1">
        <property type="nucleotide sequence ID" value="XM_038222916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222916.1">
        <property type="protein sequence ID" value="XP_038078844.1"/>
        <property type="gene ID" value="LOC119746119"/>
    </dbReference>
    <dbReference type="GeneID" id="119746119"/>
    <dbReference type="OrthoDB" id="5870811at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38005" checksum="8359E865E57AD217" modified="2023-02-22" version="1">MVGSTCVVSYTSTEYISSSRGALVYSMIGSQYSVGTCYYIFYTADDGRLLVDAEKMGLDGTGACLNFEESSDSSFNRRRQLARYCGNTLFQVNTTKRYLKIKFDSSSYTDQAEFRLVVSPFFEGGVSIETFNCDDGYNISKDMRSDGHQNCPDNSDEKGASALPCSSRMLSCGESGPCIAKDWKCDRIPDCPNASDEEGCIYKCPGSSSNGESYQLECQDKSGCFSQYERCRGNSYSECDDGSANKYCDACDGYNDYYYFANEPRFDSYCPMTRTCMTAAQLCDGTTDCPNGADEEYNLCHPSIYWYWTGGQLAGLFIGFIIFAVVVVVIVAVVHKKCRKQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS09</accession>
    <name>A0A914BS09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078750.1">
        <property type="nucleotide sequence ID" value="XM_038222822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222822.1">
        <property type="protein sequence ID" value="XP_038078750.1"/>
        <property type="gene ID" value="LOC119746054"/>
    </dbReference>
    <dbReference type="GeneID" id="119746054"/>
    <dbReference type="OMA" id="KYLGPPY"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="648" mass="72639" checksum="66DC9AD5BBFF8A0A" modified="2023-02-22" version="1">MSSLGDNSLRPPDKPDPDLDIDTSLVQLDLSDPDPSDPNLTNGTRENQPQSAPQTTEVEEECEYFESPVPEHSNVILAQLNRQRLDGRYLDFRLDCNGVTLSCHRCVLAASSPYFDKALTELEEDRDWLCLDHLKPFALKAVLEFIYSGKIKLCEATAASVLSAACILDYHNIVDLCCSYISGLIRPGNCLGIFKLSQEHGCSELQRTAWQFALDSAEDVFGQVEFLDLSVDHLVELISDEGLNVEIEDVVYEAVLRWVENDMSNRAPDLWNILQYVQLPLLSNRLFSSSLESHPLIINCEKCRQLVKEARNLRDLALKGKDTHSESLKPRPSMMKDVLVVVGGMETSRQWVKDVSYYDPAAETWETLSTLPFSQTDYSVASLNDDVYISGGFKMGSATSEVWCYKTAHDKWMEVSNLKLARFNHTSTGLDGMLYVVGGETDDVGLTEIERYDPQRNIWEIIGEANPTQSNLTVAGLNQKLYIVGWLVHAQLMCAVQCFDLKTKECMIQPCSGLNRQMFNVVTFQDLIYILGGSRIKEVAIYDPETYQSVKAEPMKYKRNTPSVAVVGRRLYVTGGELRHHLTKVEVFDPGNNSWSVVPPMPKALCFHGCVGIRKYLGPPYVEPTRRDVAAGSGECHEVFADVIDVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSS1</accession>
    <name>A0A914BSS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038079020.1">
        <property type="nucleotide sequence ID" value="XM_038223092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223092.1">
        <property type="protein sequence ID" value="XP_038079020.1"/>
        <property type="gene ID" value="LOC119746254"/>
    </dbReference>
    <dbReference type="GeneID" id="119746254"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="67"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="43025" checksum="F2E08F91F43A9887" modified="2023-02-22" version="1">MFSLVCRRFGAISRNSHRVLPAAARRQYTNEQTEASFSVLDYKLHKLESGPSANVTVTRDDALKLYRQMQVIRRMETAAGNLYKSKAVRGFCHLYSGQEACAVGIKAAMREGDALITAYRAHGWAHLMGLSVAEILTELTGRRTGCAKGKGGSMHMYTKNFYGGNGIVGAQVPLGAGVATALKYSGSDNLCVALYGDGAANQGQIFEAYNIAKLWELPCVFVCENNKYGMGTAVERASASTDYYARGDYVPGIWVDGMDVLAVREATQFAADYCRSGKGPLVMEVETYRYSGHSMSDPGTSYRTRDEVQEIRQQRDPITNFRDRMTTSGLATAQELKEVDLGVRAEIDEGVERAKNEAELPASEAFTDIYSNTAPFMVRGCDPFTTHPSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT44</accession>
    <name>A0A914BT44_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ENTREP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079359.1">
        <property type="nucleotide sequence ID" value="XM_038223431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223431.1">
        <property type="protein sequence ID" value="XP_038079359.1"/>
        <property type="gene ID" value="LOC119746469"/>
    </dbReference>
    <dbReference type="GeneID" id="119746469"/>
    <dbReference type="OrthoDB" id="10036151at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030431">
        <property type="entry name" value="ENTREP1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615">
        <property type="entry name" value="PROTEIN FAM189A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615:SF9">
        <property type="entry name" value="PROTEIN FAM189A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="102" mass="10807" checksum="D8C17D969427AA76" modified="2023-02-22" version="1">MPDGSSAGRGTEVMAGSDRVVLRRLAVRPKPRRTTLIFGVSQMILGLAIVAISFTAFALSTSNRVRNACPYWAGFSVLLTGGVGLIAWKQPSSLAVSKKPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-03-08" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E7D7K5</accession>
    <name>E7D7K5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Six3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2010" name="BMC Biol." volume="8" first="143" last="143">
            <title>Uncoupling of complex regulatory patterning during evolution of larval development in echinoderms.</title>
            <authorList>
                <person name="Yankura K.A."/>
                <person name="Martik M.L."/>
                <person name="Jennings C.K."/>
                <person name="Hinman V.F."/>
            </authorList>
            <dbReference type="PubMed" id="21118544"/>
            <dbReference type="DOI" id="10.1186/1741-7007-8-143"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="HQ148089">
        <property type="protein sequence ID" value="ADR83537.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046816.1">
        <property type="nucleotide sequence ID" value="XM_038190888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E7D7K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190888.1">
        <property type="protein sequence ID" value="XP_038046816.1"/>
        <property type="gene ID" value="LOC119721019"/>
    </dbReference>
    <dbReference type="GeneID" id="119721019"/>
    <dbReference type="OMA" id="PAGICCV"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADR83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="266" mass="30123" checksum="08571CCC6ACFFD2F" modified="2011-03-08" version="1">MLGSMFPLPTLPTLSFTPAQIASVCETLEESGDVDRLARFLWSLPVAPGTCEALNKNESVLRARSVVSFHQGNFRELYHILENHRFTKESHAKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAHATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQQQQQHQALQNSSANANGGPPIHRLSMTEGTTTLPGEESPDSGSPSVSPIGSPLLPRSVSPRPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWM4</accession>
    <name>A0A913YWM4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044194.1">
        <property type="nucleotide sequence ID" value="XM_038188266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188266.1">
        <property type="protein sequence ID" value="XP_038044194.1"/>
        <property type="gene ID" value="LOC119718846"/>
    </dbReference>
    <dbReference type="GeneID" id="119718846"/>
    <dbReference type="OrthoDB" id="9976543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="470" mass="53590" checksum="8673C89E1D635ABA" modified="2023-02-22" version="1">MFFYSCSSRASNEEQLPPAGHFNLPLPIATDKIVKANAGYKRELFEHHLERRTNYCANCNLLGVLAFTEGDEEEALKYFKMALDEDPKNLNALANINHVKGRSSSEKENSVPDLSTRAGKIQQARCYAEQAYPYIQLYHGTVKDQQYEWYNWAARLYKEAFTLAGSLVDRATRHEWLFSSGLASFKILEMMVIKRNEGCAKEALRGLAERFGAIVDSPSADNAIKCKALMHVAVAFEKASRLFVIPQEYIPKSLVKYIARPEKCLRKARDLSPDDALTAKILVRLAQMRQRPDCGGSFEEAMELLNESIALDPSKFNFLAYSSRASLCIKQYRRTNELRLLSKARRDLEFILPKHESPWDLEWLAEVYYHLAKRTAGKQAKKYIRKALETCTRCKGCQDGKKRSGLHHVRGQILCLNGQHQEAMESFQKGVACEEKTGWISGNMDSLREEREHVRKDDAARKVLESDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXQ7</accession>
    <name>A0A913YXQ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044152.1">
        <property type="nucleotide sequence ID" value="XM_038188224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188224.1">
        <property type="protein sequence ID" value="XP_038044152.1"/>
        <property type="gene ID" value="LOC119718804"/>
    </dbReference>
    <dbReference type="GeneID" id="119718804"/>
    <dbReference type="OMA" id="MRIMACD"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037456213" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="10">
        <location>
            <begin position="32"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="554"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="712" mass="78409" checksum="2D028CD1C48ABC9C" modified="2023-02-22" version="1">MDNRRPSCMHLMSAFVAVIAVFSEFCSRVAAESVKGDGQQTNQENEASKNDTCIFYHELGSDKQCDFIQKTEDCKPENGFINYLEFTYCAFSPNLQPLALVILFVWLTFLFVCLGVTAKNFFCPTLLTISKTLKLSDNVAGVTFLAFGNGAPDVFSAIAAITHAKDGDAGLAIGALFGAAVFITTFVAGTVSALKPFEVAQIPFLRDAIFVVGVAYWTFYILYTGQILTEEAIGFILLYVFYVCVVLISRKFERPVTVTTPVVDGEGSYARLEDGLSAESQDVTSNIDKPTENPQNDKPHPASKVDEKPTECTDTDNKAETGETNQDVPKDVQAENVPEKEVMEEILKPSADRKGPPKPAETCSDELEARTTDNQQRATKRTNFGTMDLGEKQVEVQDNNVTHSTEMVAAKTEEFTGGNSEEEPLLPRTKKPGSLGYQLRALFRDINPIDVEGWKNKGYIMRIFEIYKSPIQLLLQISVPLVLHDKCSWNRLLNCIQLLIGPVWCVLITNIYGTVISGEFYLWHLVLCFGAVLAILALLTSKPSQPPVYYIAFAFLGFVISVCWIYAIANEIVNLLRMYGEVFDLSDAILGLTFLAWGNCIGDLVADTAMAQQGAPKMAISACFGGPVFNMLIGIGVATTIATAENGGIFKLKTDTLQFVLAAGLGISLFTSMFFMIAARFRATKVYSVLLYIFYAVFMTIAILTESKVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZ78</accession>
    <name>A0A913YZ78_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044873.1">
        <property type="nucleotide sequence ID" value="XM_038188945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZ78"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188945.1">
        <property type="protein sequence ID" value="XP_038044873.1"/>
        <property type="gene ID" value="LOC119719472"/>
    </dbReference>
    <dbReference type="GeneID" id="119719472"/>
    <dbReference type="OMA" id="AWRCILV"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="383" mass="42422" checksum="52E6A7BC13A9ADB1" modified="2023-02-22" version="1">MQSPGSPSFFAWRCILVFFALCGNTLVIVVFVRVGRLRTLTNYFIISLAAADLITAITVIPSFFPVEGLPDDARGVIYCRLVASDVFMWTALKASVFNLIAVTLERYLAVVYPLRHKRLFSPTKAKISVALTWVIAVVLNFFGPLVQDVQDGKCVVVWHSDALRISVGVSVFLVTYLIPVLVMLVTYIRILAKIRTQTRAASQTAHRAHSQNRLVAYHAARRGVVETLFIVVLAFAVCWTPDQMMFLAQNAGHFDYEGSAIYPYFLLLALTNSCLNPVIYSIKNRSFRKSIKLAFRRKHRVGQDLSRNRRDVALQVVNGAESDKLTCTDYAGVAAETTNHPGHTDGPSRTGRPARTEPGQPDSQALCEQASDTPAPRSSDTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZX7</accession>
    <name>A0A913YZX7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045244.1">
        <property type="nucleotide sequence ID" value="XM_038189316.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189316.1">
        <property type="protein sequence ID" value="XP_038045244.1"/>
        <property type="gene ID" value="LOC119719820"/>
    </dbReference>
    <dbReference type="GeneID" id="119719820"/>
    <dbReference type="CTD" id="55183"/>
    <dbReference type="OMA" id="FTIGHEV"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1474"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1903"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1942"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2207"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2268"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2521"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1230"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1372"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1537"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1584"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1636"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1676"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1688"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1743"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1781"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1791"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1848"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1910"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1942"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1956"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2363"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2413"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2521"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2550"/>
            <end position="2572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2680" mass="290392" checksum="DAB58F4D25EE8A4D" modified="2023-02-22" version="1">MMVTACTDDQGAVCAKAPGLSPLLEALEGKGGPLKEKVGAYMTLAERLKSDKDATLSREICQHTAQLTCVVSVDIMHDDAELNQAALQALGFCLHLPDISRAFTSDDASTVVKALCNALLKTKDKSTCTRALWCLSKQNFPKQIIKNELHSILCALEHALVQGEFQSMTVDYEALNVIIRLLEDLPDDMPTHAARWGKLLFPQVVRSAHKIRERAALAMNLGLPAMVQHQPDIVSQLVTDLKSTLVPEMMKLFASKCEVQVLKTWGNFVTLLGKALHKGGGLINCLLGVVEQGFKHTSADVKLAAFVAWRVLIDNFALEPDVLYNAKRLKLLLQPLRATSAKQELVAQAKLDTWWYLVYRLGPKAAMNFEQVCAPLLQFALGLNTNVKGMQCPSTPITTNGSGLRQGFTTPLHRSGPMFSMASPATPRLSLPPGTPGGAAPPVFKSIQLQGVEILARVLGMPSDAVGTVPKYTFTIDALSHPVITSSTTFIKLSTTLVPMVRDVICNLGDQLDEGLLFQLWQALVIHVSDMVTTATKKDSVEVLTQFLTSLQCIVGGSGLAPKSLLKFLEAVSHLPKNVLGSPSYHTGNAGLMHGTPALFLIELLLSQGLLQTTAEERFFCVLETLIDCGLTVPGTVLGFCGSVLQLVDKAVDDVRNKSIIWRIWSSIVYPLLGHIIETNEVNQGDSLDHDFSTMYASLMLPIQHLLQSDSVPQMTVKTLLKTWAELYQAFARCAAVVTTADSNLGCEELCTKILACLNSQPLKSSCVDSLIQILQVIANSFDFSSFTGNATLNNPLTPGGGTRGRVRPLGNLTAFVRLVVRMIEEIQNLVKPEKSKFAGLIIQASNSYISSPSISIVANILSVLFTNVSQPYIIEALLDKLAGPVASFFDNSGAFRCSAYPAPTWQKLEKLWTDLLTSVQTRYGGPYNSAFLASVSPLLESGLTHPKRAIKSHGLVFWNATFATVESLEYPEPLKLCFAKLKEKTPLVLPGWTDAEQQVVNETPVSQISESEASQSLIPPPTVATIPNFGAPSPQKMHGSFLRRSAQAERLFASSSPERYKSPSSFGKTGKRSVSPGKGALRGLSSPVGGKGKRDGSPAVGGAAARRRLHVDEESMGEFVFIAPSPKKTQVLTDHQKEMMRTRRVLPALYNDLEQSQDTQTFTEIMTQPEHSQGSPPVEQEDGAAASISDDSPSLFGFLKEHTSVQEKASENKEASIQADRPATAADEIEQKTRTESDQKETGKQEVSHSDTTQEGKPLTFEGIFSTVKKSEEKSVAPALAVSSNSKDDEKQVKSLPPAKTEVEFSTDSTKGEPTGCAEGAIETGVRTPEDMLPTASENLGIGQEKRVQAGNVESLLKKQESNGNTLEVVETGKEDQKVLAKDSTDDESGDDKKDEKSAEGVFVIPETQQSPSMEMAVSKADDILAISPARSGSDSQPANLKLNLTPVIKLQKLNEADLLRLSPDPSKCSFGKLDINSSPKMFTSSEEEATPNRFVTRLRLLSSDDASKSNKKEKSLKRAASEPAMPNSKSEKMVQKRAARGRCQRPAKKSLQSSQADLAELAERFELDGIEPLADETDMDQSVDQMDSESQSEQVSLSNHDGISDSVSEADSGSGRGSAGPRKVRGRKRKDVSGKQNPSTKSNTATGDNNSNLSDSYAADESVVEDSNETKVTTSDKTDQVDIKVQKKRGRPRRVKPTTLSPVEEAPVHPNSKEQTQVESKSGKGQVPARKSSMRLGNKISTEEKQEDKICEEPLQVLVSEENTPADKPKDSTVASQTVDKEALDLKDSQATQEAGSSSSIPDSQDGQLNSCDDLFESCPKDTSGEGLARSVQVETKSEESLASRRTSKRTRRPSKSKLGLGKRKRQILDSNEDSEEDNIPLAKIRHCYLDVDSQTSDSEVDFPKINVEQTPASNAKESPRIVKEKEEVKCEDIKREHLTRVKTRSEKKELGKSPKFSPKTSPKAAFARKILKRARKSPLSKKSSPAKTVPSTKVAAKISPVATRLRTSKYLSSLSASVPSKLSRKSRKVLKVGREKTDGSKVIKKSVFEEKLEEAVKEDILDDIFSGEFGDLWEDLSPIAGLSTSLPLPDSKSLLSPSPVSFIEEDIHEKDIGFTNEATVLPSENPPSATKRDTALLADLKIPNLIDAEAAENEEILSSSFELAETIPDPTEEAMESSPNAPSTSFQAIPLPDVSEINIAASNEKPQDSVAEGTPLNECPSFSPKVALPQSPVIPMKFAPSCHSSPNVSGTARIKLVDQGSPSGYIPAMYSPSGSPSGGILKRKDSASPSPSNKSRRVSFAEPISEHSPVKQFAVELLPPEPTEDKPSKVHRVTTHPPSPLVTTTPSKVVSVHSKFITTPSRRSSSSGGLGGRSRVSPSGRRISPGSARRKARQQGFVTPSTGRKPKPIRQSSQNSEGTLLTQGTQQNSLDNSIDSDYDNQESVFPDLAECGTPVERILPQLTSSMWSRGLGQLVRARNILTVGHLCSLSPTEIRSLPIRSPKISNLRKVMTNFQKQQIAKNGGTPSSTTTKKKEEGLAVDGGVEGRGAETKATEGRKEIEEGPVEKQDLQAPATPSEPSTSKEATTSKEEKAQSKQGTKRKHDEVESGSSNEEESSKPKQAKIVDKLEDLVGEFATEKLAELPSERLFLAHQHVNSMMESIMAALKVKVKSPSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1H9</accession>
    <name>A0A913Z1H9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045678.1">
        <property type="nucleotide sequence ID" value="XM_038189750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1H9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189750.1">
        <property type="protein sequence ID" value="XP_038045678.1"/>
        <property type="gene ID" value="LOC119720182"/>
    </dbReference>
    <dbReference type="GeneID" id="119720182"/>
    <dbReference type="OMA" id="EGPNCTD"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037678965" description="Laminin EGF-like domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="337" mass="36733" checksum="62692C9878DB15C2" modified="2023-02-22" version="1">MNSPLGFIIAGTAIVVCFHWICVGASVSSGVVNITVTNTSDCVCNPVGSLNTTCDNTTADCLCRNGYEGPNCTDCQDGYYHHSNRSAECIPCQCDETGSLNNSCDRYATCSCKPGVGGKQCNQCLSGHYELSATGCKQCTCDKVASVCLDQSKFRSSSHPSMCHYCLLNETWVNQCTKPTCLPSEYLTPDSVCTPCQCGQSQGTVHGTRQCDLMTGKCPECEGESCSKGGNSQYQVYIIVSGAAAGVVVIVLAILLTVYCRRRCRRQANRPRLPLWTIELRQDEDRDEFDATQELAFDDLDVMYLDDSYLMEPTPEYFNESTDNLNGRAGYHTLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2Q7</accession>
    <name>A0A913Z2Q7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cathepsin F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045992.1">
        <property type="nucleotide sequence ID" value="XM_038190064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2Q7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190064.1">
        <property type="protein sequence ID" value="XP_038045992.1"/>
        <property type="gene ID" value="LOC119720396"/>
    </dbReference>
    <dbReference type="GeneID" id="119720396"/>
    <dbReference type="OMA" id="RSATPFW"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000130">
        <property type="entry name" value="Cysteine proteinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037700485" description="Cathepsin F" evidence="10">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="11">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="13">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51555" checksum="1D498532A07CF0B9" modified="2023-02-22" version="1">MGYVLQIVLAVFLFVCSTEAFGRRVGGLQYIDQEDDDIQNLARFAVDEINKKSNDYFRAKLVEVRQAQSQVVSGILYHMNITIWDTVCSKIEFVTDLKDCKFNNQEKKQRCSVNLWVVPWDNVKSLEDYHCTPESDKVSETFPFYQEFEDFRKKYERPYEKNSDEYVKRYYLFSDNMERVRVLNENERGTATYGATKFADLHPDEFKKMYTGLKVPAKSSSHSDMKQAKIPDGPTPASFDWRTLGAVTKVKNQEQCGSCWAFSTTGNIEGQWKIKKGKLVSLSEQQLVDCDKIDEGCDGGLPSDAYKETIRMGGLETEGEYPYKAEDEKCELNKKDIRVYINGSVNITSDETKMTTWLANNGPISIGINAAMMQFYFGGVAHPFKLFCNPQSLDHGVLIVGYGTKPGILWGENPYWIVKNSWGPDWGVQGYYLVYRGDGVCGLNTMCTSSVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z351</accession>
    <name>A0A913Z351_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045135.1">
        <property type="nucleotide sequence ID" value="XM_038189207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z351"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189207.1">
        <property type="protein sequence ID" value="XP_038045135.1"/>
        <property type="gene ID" value="LOC119719710"/>
    </dbReference>
    <dbReference type="GeneID" id="119719710"/>
    <dbReference type="OMA" id="ACEIRYL"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="33388" checksum="81A15FC5FAA8F6A9" modified="2023-02-22" version="1">MPDPAPADVAAPEGALPPKPVLHPVAAVSLKLPPFWPNDPTLWFAQVEAQFLTRNITTQATRFAYVIASLQPEIAQEVRDLLITPPTTDQYDRLKSELIRRTSLSEQKRLHQLLISEELGDRKPSQLLRRMRQLLGDSSLEDKILKQLFLQRLSTSTQSILASMADSVGIEQLADLADKIVEVSPPSTASAVGIAAPAPYSPPQTQLPQAHPDILVLQDQMASLTRQVQALTTQLQRGQARSRSRGRPKSRTYPADRSPSAPAGRSGDRQCWYYWKFGSKATKCTSPCSRRTPPVSENPQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z397</accession>
    <name>A0A913Z397_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045180.1">
        <property type="nucleotide sequence ID" value="XM_038189252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z397"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189252.1">
        <property type="protein sequence ID" value="XP_038045180.1"/>
        <property type="gene ID" value="LOC119719763"/>
    </dbReference>
    <dbReference type="GeneID" id="119719763"/>
    <dbReference type="OMA" id="IVVCKET"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="16472" checksum="37B220513B7A7DA1" modified="2023-02-22" version="1">MLQRKTLPELIQPMDARIASVRDFIHDIKPRILQSDSIVPITDPYSPSVVDPDMRSIVVSEETKKGGDAVNRVRQQKGLCVLDVHEISLVEDINHAAHEEAKISSSTQRIGLLGTLLKQPTVSFEAKSETLFCRVSRFRCMAMLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3E1</accession>
    <name>A0A913Z3E1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045526.1">
        <property type="nucleotide sequence ID" value="XM_038189598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189598.1">
        <property type="protein sequence ID" value="XP_038045526.1"/>
        <property type="gene ID" value="LOC119720076"/>
    </dbReference>
    <dbReference type="GeneID" id="119720076"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="33782" checksum="2A3D00B1A9FD0C95" modified="2023-02-22" version="1">MGEEGIIGTMRLSEFWDYVPGNPLKPPVEMAWTYMTDNYTRFQIATLGSVLVHMLSYYLISTPSILCQFLPFMQRFKIQNDKPETAKNQWKCVKLLLMSQLFIQLPIICASYLYCEMFSIPFEWDKMPAWYVLLAQFYACLVIEDTWHYFLHRALHDKRIYKYIHKVHHNFQAPFGMVAEYAHPAETMILGMGTMWGILLMGNHLAFLWGWMVVRLLETIDVHSGYDIPMSPLHLLPFYGGARFHDFHHMNFNGNYSSTFTWWDKIFGTDRQYKDYIKEKTDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3S0</accession>
    <name>A0A913Z3S0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apextrin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045355.1">
        <property type="nucleotide sequence ID" value="XM_038189427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3S0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189427.1">
        <property type="protein sequence ID" value="XP_038045355.1"/>
        <property type="gene ID" value="LOC119719943"/>
    </dbReference>
    <dbReference type="GeneID" id="119719943"/>
    <dbReference type="OMA" id="GEPRCQK"/>
    <dbReference type="OrthoDB" id="5954510at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038030876" description="Apextrin C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="299" mass="33903" checksum="E044FE3005BA64D4" modified="2023-02-22" version="1">MDALLSTGVRFLLLAVLELSLFRSVITVLHSGRMDGYALPRPLTGCTEHWADFRVRLRYSNLTHETNISEEFQLALDTLDDDTVLFEFCVQNKTLVREGSIDDQVLDWPAGQYCIHSVGKIARKDGGVFEWVLGDCPRGFKSGVTALPFKSFPGQRMVDPTSPLSLTYPNITLVHYCCSNTGNVDTAIDLGMVAPFYLMPYGEPRCQKVQNMESDLQFIEWPLAEQRWSGTHPYSVRGRKFFYCYYQPMGLGMEHDIVIATFCVAIGTPTLTMIVICLCKLRAKLSARRKHFKRFQSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z539</accession>
    <name>A0A913Z539_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046837.1">
        <property type="nucleotide sequence ID" value="XM_038190909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z539"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190909.1">
        <property type="protein sequence ID" value="XP_038046837.1"/>
        <property type="gene ID" value="LOC119721035"/>
    </dbReference>
    <dbReference type="GeneID" id="119721035"/>
    <dbReference type="OMA" id="WIEEVEH"/>
    <dbReference type="OrthoDB" id="10065209at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19963">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19963:SF30">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36921" checksum="E7BBE4C34E2FD02E" modified="2023-02-22" version="1">MPKEMEGAEGGPSVSHLMDELEDLRSLFHQTQEFSKVKSPTYLLVPSQKKLQSFSGKSSDIKLEDWIYDVSTAVKARPLSKKAEIDFALQYLTSSAREEVKYHKVGSLEALFSVLRDTFGDHGSSVRLQRTFFERKQTQEESLTSFSHSLLDLFTKAARKCPQLMEKREHLLKDQFAEGVHDVLLRKYLKSKLRGSPGIDFFALRTEAIEWAEESEGAASSSNPVTISRQSAKEEPSARSLLDIMVKQQEQIDHQQKQLDELTTLVQQLAQAKPNNSTGRQQTKVTCTFCSKAGHTAERCFKRQLKEAHGTIEELRKATKSPPSQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z666</accession>
    <name>A0A913Z666_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047303.1">
        <property type="nucleotide sequence ID" value="XM_038191375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z666"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191375.1">
        <property type="protein sequence ID" value="XP_038047303.1"/>
        <property type="gene ID" value="LOC119721341"/>
    </dbReference>
    <dbReference type="GeneID" id="119721341"/>
    <dbReference type="CTD" id="8664"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="558" mass="64657" checksum="0DEF1FCF2A828D62" modified="2023-02-22" version="1">MSAHFVAPVIQENPTGWGPCAVPEKFKDIPYQPFSKGDRLGKVSDWTGATYQDKRYLGKYSSQFGSGNQYTYYHEQDESSFQLVDTARTQKPIYLRNRMRFTQQRTMRRDRDRREQRQQQVNMQTLTKAQKERQRQVRRLQKQYGKGRQKWSDKGNNRFWKASGPVKTRSASVQVRSEWEVIEELDFPRLNKLRYPDVSESEDLVTCGEMEYYDKTFDRITTKSQRRLARVNRIFHKVTTTDDPIIRKLAGKGKVFATDIILATLMCCTRSVYSWDIVVQHVGGKLFFDKRDDPEFDLLTVNETAIETPQDEGNHMNSPRNLALEATFINHNFSQQCLKKNGERYKFDKSNPFQEDDDSEVASVGYRYRKYNVGDDLDIIVRCEHDSVMMGSNGETQFVSIKTLNEFDSKSLGIAEWRQKLDSQRGAVLATELKNNSFKLSKWTVCALLSGSDQIKFGYVSRLNPRDSSKHVILGSQQFKPVELASQITLNMENCWGILRCIIDKCFKLKEGKYLILKDPMKPVIRIYDIPDNTFSSDDEAEETSSSSDEDDDNDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z761</accession>
    <name>A0A913Z761_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047562.1">
        <property type="nucleotide sequence ID" value="XM_038191634.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191634.1">
        <property type="protein sequence ID" value="XP_038047562.1"/>
        <property type="gene ID" value="LOC119721554"/>
    </dbReference>
    <dbReference type="GeneID" id="119721554"/>
    <dbReference type="OrthoDB" id="5852403at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1603"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1663"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1694"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1769"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1819"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1853"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="996"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1141"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1582"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1885"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="6"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1294"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1306"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1916" mass="213049" checksum="2383701F2E1A6FC5" modified="2023-02-22" version="1">MIQVTCRPDEFKCGESICYDSTIVCDGRQDCDSSPHDEEDCDYCDDDYPIILSARNSSYDIKYPGGRLRGDPTSLTSTSANCSWTVQASSDQVIRIRFLVPTTHPYLDAFVLSFTVGSETVAMYNGKLKEPSMSITNSAVQITFIKSNFDYPGRLHLRVESEYPVSCENGTEFNCEPDNVCIPISKRCDGFPDCDSKADEIGCGECRSNRFRCLTSDGQSKCVSSDYNICDLEPDCKNMYDELNCAICGPPVNVSDGGIYQLTLPRTTDSMFCVWLVYASPGHLINIRVSDTSLIILGNILVGSGHDPSNESSTIINKSTGTIPQVITVHSGKAWIPCAVSNNNFSFEITQLSEVVQCNTTTEFACSSGVQCVAADLRCDSVRDCNDYSDELGCLTCSKDQYLCGHQGACVDSQQICDSYNDCGNFEDEWDCYTTCGPRLVHVNVSVVISMPPTQNGIYVCVWQITSDPNTFLTMEVLKMEIGYQSYAAFGNGDEVYSLSSLVANEINVQVAGTLYLFDGSQVWMVTRSFWNEIDFEVRLNAGTVKGSCDAQSLQSGSKCVPGSARCDGRADLPDYSDEVDCGFCGTTNLNLSTHTEVVTVEVVNPRPRQQLVTVYVHRNQDIPLVIANTSSNISECVWKVSSSIGNVIEINVAKFAGNNLRIGNGHDPSEGVPILSHSWIWLFYRKLFSSGSALWITTGLYSYDWEPYQLQFTLRSFASIDCDEGQFACSSGTKCLEQSSVCNGIHECPTYSDELNCTSCQEEEFACSTGECIRIEKVCDRYSDCPKLNDVYNCGLCGDPNIALNASVSRFFTAAFDVDRRYDCVWTVTAEPSTRILITVLTLRYAPTTFCDGNYGDFVRDSNRSQCTELADFASYDRIFRRHISSSGPALWIKNTGYPYVDNWDITLTLSQFVDVVCQNGEYKCPSGRTCIDQSAVCDGWPDCPEYEDEFGCRGCSEEEFTCGTGWSGCYEKKHICDEYASCSDKSDELNCGPCGDSLINMTLGYANLTSAGWPGNYPSNMRCYWVVLAPMEHRILVIFIEFETEGVYDYLQWSNGRSFNDGLKISGSNGPSRVASRGNELALHFYSNYYDESKGFLLQLEQRSEDAISCGVGEVLCDYPEFICVPENTESLRCPTNHCGEETISVNLLPVSFSSPNYPADYPDELDCTWTIITLQYRVIFVQIEDFYTELNDDVLLLQGPTFYGVLPSDFRFDGTTKVRSMVFNSSSIFIQFTSDWIFGMRGYLLSIQSSLPFNDPTWCEEVESPSEDCEQFGIERIPVSCDMNNKSLFDCKDGSCVIPEARCDGFTDCKSGLDEQNCQNTHCPEFYACNASSKCIYWEEVCDGTVNCGSGDDEIDCDTKRCPNGCQCNYDVDDFHVRCQQGWSPSTLANTARRTQALQLTNGDILTLESGGFKGLHYLEALYLTDNHIQWIQQGAFTGLNITYLDISNNNITRIDLPIFNELEQLETLMMVNVPIRSISTDAFQGLSNLETLVIITKLRGDMFIEVEKGAFQELESLQTVYVDDYRLCCDFAELEHFSFETDCHTTELQPPLNLCGSLLQNNVLRVALWVLGLSALLGNVVVIIWRIKGAGGRGGKKTHSFMVLNLAISDFMMGVYMLMIAGVDLSYGEAYFRTASVWRSSVVCKIAGVISVLSSEASVFFVTLISIDCFLCIVFPFNRGIHLRERSTKIAVSLLWFVAFSLSVVPTILVEPESDWYGLSDVCIGLPFTTKATREDSSQAELDTNNPLGSQQLTLNXGTDKKPAWILSVVLFLGVNLVCFLIVFCCYVAIFVIVKRSSKLVRKSSHRNREIKMAVKMAVIVGTDFACWMPVIIMGILSQTNTIEIGAGMYGWIVVFILPINSSLNPYLYTIYSACTRQTTSNSDSQDKSEPKNPKACSVETLDVSMSELRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z786</accession>
    <name>A0A913Z786_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C3/C5 convertase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046866.1">
        <property type="nucleotide sequence ID" value="XM_038190938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z786"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190938.1">
        <property type="protein sequence ID" value="XP_038046866.1"/>
        <property type="gene ID" value="LOC119721060"/>
    </dbReference>
    <dbReference type="GeneID" id="119721060"/>
    <dbReference type="OMA" id="YTKPWHV"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011360">
        <property type="entry name" value="Compl_C2_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001154">
        <property type="entry name" value="Compl_C2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 19" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 19" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="22">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="22">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="22">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="276"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="21">
        <location>
            <begin position="484"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001154-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="767" mass="86651" checksum="C44695158EA86C62" modified="2023-02-22" version="1">MTLLQFCKRFSIVKRKTMPRKKHLKLLVLMYFVEVMCPSLLESEAEISHLQSNTANRTYRLGEVLDYRCDAGYRILGKTWRECSGPSLHFPNRTWSDLDPICSEIECPDPGHIQFGGSRYLESRKVGGRVTFRCRSGYSLQGSRVRHCLPNGKWNGSLTTCDHESFYCPNPGIPIGGRMVNARGVRFRKGERVSYECNRNRVLLGSDERECLKSRGWSGEPPTCRGPYDFDDSVEVAARMAYDIEGLASNLETTTADNAPGPRGRFIDVRHPGGMDIYFVFDASGSIPKAHFKYYVDLAKVLVTQVGEANGRPRARYGVCLFASKARMAIHVSEPQRTVRVVHFALDDMITRLSQNYYQIGKGTATGKALKLVHENIKEDDRTAKKYLFLFTDGKTNMGAHIGLPETEAKVLREHYHFEIHCIGVGLETDVRELRAIASGQDNMFLIKDYWDLNILAQVITRQKLDYSPCGRNGKSHQQPSSRIVGGDNAKSGEWPWQVALFCEDVTGSDGYVPRFFCGGSLIARNWVLTAAHCFRDNHCPWSDIRVYTGIINKSKRKLQNVNPSLVYNLDGEDALIRHGEYNDHNLDNDIALLRLSRNATFSPSVRPVCMPQPTMQDSTIYAQRGDAFVTGWGSNQTCNIDSECRRHDSSKYLKQLAVPMRTNKECRESLKLNYTKKYSEFNYKHDLAFCAGYEEGNQDACKGDSGGPVMRQMTVADGSKRWVQIGIVSWGEGCAQKGRYGIYTRLSAYKDWVQDHIGSAPYAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z849</accession>
    <name>A0A913Z849_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047030.1">
        <property type="nucleotide sequence ID" value="XM_038191102.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191102.1">
        <property type="protein sequence ID" value="XP_038047030.1"/>
        <property type="gene ID" value="LOC119721196"/>
    </dbReference>
    <dbReference type="GeneID" id="119721196"/>
    <dbReference type="OMA" id="PYHIECK"/>
    <dbReference type="OrthoDB" id="6612025at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000714">
        <property type="entry name" value="Titin novex-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056701">
        <property type="entry name" value="DUF7799"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058157">
        <property type="entry name" value="Spectrin_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25075">
        <property type="entry name" value="DUF7799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25101">
        <property type="entry name" value="Spectrin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24915">
        <property type="entry name" value="Spectrin_SESTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="43"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="43"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="10032"/>
            <end position="10050"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="19">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2353"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2470"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2565"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2664"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2761"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2858"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2955"/>
            <end position="3044"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3052"/>
            <end position="3141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3149"/>
            <end position="3238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3246"/>
            <end position="3335"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3345"/>
            <end position="3434"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3446"/>
            <end position="3536"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3555"/>
            <end position="3659"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3677"/>
            <end position="3773"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3780"/>
            <end position="3868"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3876"/>
            <end position="3964"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="3975"/>
            <end position="4062"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4102"/>
            <end position="4190"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4198"/>
            <end position="4286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4330"/>
            <end position="4420"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4448"/>
            <end position="4538"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4745"/>
            <end position="4828"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4880"/>
            <end position="4969"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="4979"/>
            <end position="5062"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="5126"/>
            <end position="5216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="5271"/>
            <end position="5357"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="5420"/>
            <end position="5510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="5564"/>
            <end position="5654"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="5704"/>
            <end position="5791"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="6164"/>
            <end position="6271"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="6286"/>
            <end position="6374"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="6392"/>
            <end position="6483"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="6496"/>
            <end position="6592"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="6629"/>
            <end position="6719"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="7953"/>
            <end position="8045"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="8387"/>
            <end position="8472"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="8648"/>
            <end position="8709"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="8742"/>
            <end position="8833"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9032"/>
            <end position="9116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9166"/>
            <end position="9261"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9495"/>
            <end position="9587"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9606"/>
            <end position="9691"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9709"/>
            <end position="9799"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="9803"/>
            <end position="9890"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="9899"/>
            <end position="9992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="835"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2123"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2272"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="4275"/>
            <end position="4331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="4421"/>
            <end position="4449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="4619"/>
            <end position="4645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="5080"/>
            <end position="5134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="5259"/>
            <end position="5280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="5832"/>
            <end position="5921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="5958"/>
            <end position="6182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="6743"/>
            <end position="7513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="7547"/>
            <end position="7605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="7627"/>
            <end position="7665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="7706"/>
            <end position="7731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="7857"/>
            <end position="7918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8051"/>
            <end position="8148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8197"/>
            <end position="8218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8509"/>
            <end position="8559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="9147"/>
            <end position="9180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="9345"/>
            <end position="9366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="9384"/>
            <end position="9416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="9479"/>
            <end position="9503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1825"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1888"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2293"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="4277"/>
            <end position="4291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="4421"/>
            <end position="4443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="5846"/>
            <end position="5871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="5875"/>
            <end position="5887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="5963"/>
            <end position="5972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="5977"/>
            <end position="5998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6039"/>
            <end position="6051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6133"/>
            <end position="6143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6743"/>
            <end position="6764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6772"/>
            <end position="6793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6809"/>
            <end position="6823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6831"/>
            <end position="6857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="6873"/>
            <end position="6885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6896"/>
            <end position="6924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="6960"/>
            <end position="6970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="6972"/>
            <end position="6999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7031"/>
            <end position="7045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7061"/>
            <end position="7071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7112"/>
            <end position="7132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7205"/>
            <end position="7217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7222"/>
            <end position="7232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7247"/>
            <end position="7262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="7275"/>
            <end position="7287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7296"/>
            <end position="7312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7319"/>
            <end position="7354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7373"/>
            <end position="7399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7423"/>
            <end position="7434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7496"/>
            <end position="7511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7560"/>
            <end position="7571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7580"/>
            <end position="7590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7864"/>
            <end position="7892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="7893"/>
            <end position="7907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8063"/>
            <end position="8101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8509"/>
            <end position="8531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8540"/>
            <end position="8559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="9345"/>
            <end position="9357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="9397"/>
            <end position="9406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="10051" mass="1117597" checksum="4CA5C3299ECD8E92" modified="2023-02-22" version="1">[encoded data, 10051 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9F6</accession>
    <name>A0A913Z9F6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Midnolin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048382.1">
        <property type="nucleotide sequence ID" value="XM_038192454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9F6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192454.1">
        <property type="protein sequence ID" value="XP_038048382.1"/>
        <property type="gene ID" value="LOC119722381"/>
    </dbReference>
    <dbReference type="GeneID" id="119722381"/>
    <dbReference type="OMA" id="PSHDIGQ"/>
    <dbReference type="OrthoDB" id="1916003at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01804">
        <property type="entry name" value="Ubl_midnolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039336">
        <property type="entry name" value="Midnolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010:SF1">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50216" checksum="AA1782CF256676AE" modified="2023-02-22" version="1">MPHTIYPEDPCSGPAAMAVNYGMEAPSSTSPARGLLTVHIHPTTGGRFTMEIPRHASVEMLKTKISKQLRVAKERLTLLHRETHLKRGTLEENLVTDGSKLTLLPLVESGLVSQRQDQTLMQALQNLSETQVDNFLNGKQPLTLALRLGTHMVFVQLQLAGTPGQHSFLNCHKAATPGRPKPVVTRHQATPTASSCQSPPVSQNYQPPCPQSQCPLHGKTACVAPSLPGRPPQQYPSNIPPSSSSCGHSRSTMSSPTTPSSSTSSPTPSSPTWPRPGACIDSVHQHSPGVFSGTFSGILSAAVQDGQGRPKKDISTIAHILGDLLHAAPLYRQHVHQQRRQRASCAQAHHAQRTTANHAAPAAAGGSVPTRPQTPPEKKQFIMQENNHTRSKMAHLQEMMRERQARRQARRNTRAPYPGLDLHSQRNYAAHVEKGAGLVENSKERALADNCYPALKQDYLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCE4</accession>
    <name>A0A913ZCE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048716.1">
        <property type="nucleotide sequence ID" value="XM_038192788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048745.1">
        <property type="nucleotide sequence ID" value="XM_038192817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192788.1">
        <property type="protein sequence ID" value="XP_038048716.1"/>
        <property type="gene ID" value="LOC119722602"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192817.1">
        <property type="protein sequence ID" value="XP_038048745.1"/>
        <property type="gene ID" value="LOC119722613"/>
    </dbReference>
    <dbReference type="GeneID" id="119722602"/>
    <dbReference type="GeneID" id="119722613"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="114" mass="13039" checksum="82EE1113C533F936" modified="2023-02-22" version="1">MAVEMSIENLKKTSAADDFQDNSEDGTMNLIHVRCQQRNGRKMITIVEGISPIYSQHRIVKKMKKFFNCNGNVHKTEQDFGDVIQLQGDQRNKVKEFLVSCELAKESQIKLHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD11</accession>
    <name>A0A913ZD11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049672.1">
        <property type="nucleotide sequence ID" value="XM_038193744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193744.1">
        <property type="protein sequence ID" value="XP_038049672.1"/>
        <property type="gene ID" value="LOC119723185"/>
    </dbReference>
    <dbReference type="GeneID" id="119723185"/>
    <dbReference type="OMA" id="EIECHFN"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="661"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="811"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="104282" checksum="578FA6D5B4D0DFA2" modified="2023-02-22" version="1">MHGRYKTEIENLLDKGYAERVLSSDIDASPGGTWYLPHHNVVNPNKPEKLRIVFDCAAEYAGTSLNKNVMQGLDMTNKLIGVLVRFREQRVAVMGDIEAMFYQVKVTPSHRDVLRFLWWRDGDIANQPEVFRMAVHLFGGVWCPSCASYALHRTAEDHKDEFDPEVITTVMENFYADDCLKSVENDEKAMKLVEQLCKLLSMGGFRLTKWLSNSRKLIESIPLEERAKSAKEVDLDNGLLPVERALGVHWDTHTDVLGIKIKPKEKGYTRRGLLSIVSSVYDPLGFVCPFVLQAKKIFQDECKRGKDWDDELEPGNLEQWMKWLQGLPKLEEFSVPRCIVPREFGTPTSVQLHHFCDVSMVAYGAVSYIRLVDNRGHIHTSFLMGKSRLAPMKSMTIPRLELSAAVMAVRMDSILQREMRLEVQSTTFWTDSQIVLQYIKNTSKRFQTFVTNRVNVIHDGSLPAQWRYVDTRSNPADDASRGLDAKQILCQPRWKQGPAFLSADETAWSVEPEASPDLLQDDKEVKHEAKTCAVEAVAPDDLINTLLKRYSSWLRLKKTVAWLLRFKAWLRNHRQQEPEVSLQVHDLQAAEKAIIAHLQEKHFGEEVRALKTNGTISRKSAVYSLDPVVDDDGLLRVGGRLKMAPLTEQAKHPLIVPREHHVTELIIRHYHERKSAHSGREYVLCLTRERFWIPRARPLINRVLRDCVVCRRIRGKTCAQRMADLPKGVWERQIRTVRKVINSLLKDQVLDDERLDTLFCEVESVVNGRPVTPVSDSPDDAETLTPNHLLLLRAGQPAPTGNFIKQDAYGRRWRHVQLLADQFWKRWIREYLPTLQLRRKWIDPQRNVVAGDTVLIMEETTPRRNWPLGLITRTFPGKDGLVRTAEVKTRQNIVVRPVDKLCLLESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEC8</accession>
    <name>A0A913ZEC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049829.1">
        <property type="nucleotide sequence ID" value="XM_038193901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193901.1">
        <property type="protein sequence ID" value="XP_038049829.1"/>
        <property type="gene ID" value="LOC119723330"/>
    </dbReference>
    <dbReference type="GeneID" id="119723330"/>
    <dbReference type="OMA" id="NIWARIG"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="16048" checksum="3D3CBF2488537579" modified="2023-02-22" version="1">MVGKFGIAGALSVSDLYVAELLPTQVRNVGSGMNGMGFGVGTTLAPYITRIQDFWPPATMLIFGILTILAAIPVFLFLPETMGRDLPTTIEEGENFTKRPHKKEEKDVVTLGVSMVSVEVQANMKRIKQSEIDNVGDKCQDEETVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGE5</accession>
    <name>A0A913ZGE5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050121.1">
        <property type="nucleotide sequence ID" value="XM_038194193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194193.1">
        <property type="protein sequence ID" value="XP_038050121.1"/>
        <property type="gene ID" value="LOC119723504"/>
    </dbReference>
    <dbReference type="GeneID" id="119723504"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="114" mass="12907" checksum="DB66D30616C54797" modified="2023-02-22" version="1">MAKQSKGIKQCLERYMSYMASVPVNSLAGDYEQSLVIPVGHLKNLNRGTRAKVCELRRRRIHKLTRKRVCNQRAMKWLSSLLKKKPCARGNTGKDVCDGSGKGSRKKQMTICLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI31</accession>
    <name>A0A913ZI31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051044.1">
        <property type="nucleotide sequence ID" value="XM_038195116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195116.1">
        <property type="protein sequence ID" value="XP_038051044.1"/>
        <property type="gene ID" value="LOC119724177"/>
    </dbReference>
    <dbReference type="GeneID" id="119724177"/>
    <dbReference type="OMA" id="AYPWIEV"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="142" mass="15654" checksum="D2DCEC02D71EAB18" modified="2023-02-22" version="1">MEDGTIQDDRITASSILSNTYPAREARLNNDKGWLASSDDAYPWIEVDLVQSTVVTGVITQGSYSRYVTAYKVAYKKQPSSDREHVTDGNGNVKVFIGNTDADTPVTNLFDESVVATVVRIEPTAWQIVVALRLELLGCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJB4</accession>
    <name>A0A913ZJB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051444.1">
        <property type="nucleotide sequence ID" value="XM_038195516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195516.1">
        <property type="protein sequence ID" value="XP_038051444.1"/>
        <property type="gene ID" value="LOC119724456"/>
    </dbReference>
    <dbReference type="GeneID" id="119724456"/>
    <dbReference type="OMA" id="FLINDNA"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037251569" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="37333" checksum="AD30E7BD95FDCD28" modified="2023-02-22" version="1">MKLLLAVFLGLLAAVSSSPVKSLKQDFVEYSADLVEKINSMDTTWRAGRHFAGETAASVLDRFSTAGLSLEKAPKLPVVEYDRAGAIPTEFDARTKWPNCPSIGRVNDQGRCRASWAFSAVGAMTDRQCIVHPSAPFNYSVTDAVTCNVFHEVPDGCAGGYSADAWSTWVLDGLVSGGGYHTSNGCRPYAYKPCDHYETGSYGPCESPPDSTYCNKTCINGYTKTYAEDKKKGDYRYDLPLNETIIQEDIMTSGPVSADMNLYQDFLNYRSGVYQHKTETRVGLLTVKIIGWGVENNQKYWLCVNSWNSEWGDKGLVKILRGTDECGLEANVHAGKVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKX9</accession>
    <name>A0A913ZKX9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="RefSeq" id="XP_038051745.1">
        <property type="nucleotide sequence ID" value="XM_038195817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195817.1">
        <property type="protein sequence ID" value="XP_038051745.1"/>
        <property type="gene ID" value="LOC119724663"/>
    </dbReference>
    <dbReference type="GeneID" id="119724663"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000001">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="642" mass="72984" checksum="EE0E068FE0DA738F" modified="2023-02-22" version="1">MGLLSLGKPLSWEEIKANGYDEHIRRHGLIQFVSLYNKLKDRPCDVLKWGDEVEYMLVKLDHENKSAKLLLKAEEILPTLQEQEENNPKGDLKTLWRPEYAAYMVEGTPGKPYGGLMAHLNTVEANMKFRRQEVEKLLDTAKGETALSLTAFPRLGCPSFSTPSYKPNPSDEGVSKSLFIPDEVIYPGHPRFRSLTKNIRKRRGEKVAINIPIFKDKNTPTPFVEEFVNDHDGEGARAAKPDHVYMDCMGFGMGNSCLQMTFQACHINEARHLYDQLTPLCPIILALSAASPIYKGYLTDHDCRWNVIAGSVDDRTPEERNLEPLKNNKFVIPKSRYDSIDSYLSPNGERYSDIDLVLDERDCQELMDKGIDRQLARHIAHLFIRDPVSVFAEMIDQDDSKDSDHFENIQSTNWQTMRFKPPPVNSNIGWRVEFRPIEVQLTDFENAAFVVFVVLLTRTILTFKLNLLMQLSKVDLNMQQAQKRNAILNSKFYFRKDLQSCACDCPIENEQCLMSINTIINGGPLGDGQGDFPGLIPLINQYLASVETDLDTRCTIMCYLKLISDRASGKLQTLAAWIRDFVDSHPEYKHDSVVTDRINYDLVTACDQITKGQMTAPELFHCTESKSSNDIPNSVKVAQEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ40</accession>
    <name>A0A913ZQ40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053250.1">
        <property type="nucleotide sequence ID" value="XM_038197322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197322.1">
        <property type="protein sequence ID" value="XP_038053250.1"/>
        <property type="gene ID" value="LOC119725759"/>
    </dbReference>
    <dbReference type="GeneID" id="119725759"/>
    <dbReference type="OMA" id="PLSCHEI"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="50026" checksum="65BCA69140622F7F" modified="2023-02-22" version="1">MLRARSRLSKYNERSQDSRSIFWCKSMATVPEETRVKAYNWCRDYLGGTWRRIKYDDFQIRDLRGLSPQIAPRHFVCALPPWVACANISEPRQALLHLYRHPIITGTPPSTHKGRKNEPTEVLLRVFGEIFYESDAPLLDTIIFSLLSERQQGPKLYGVFQEGRLEQYIPSRCLTTAELADPKFTVEIAEKLAKFHQLELPLCKVPRWLNQVLDKWTNLTLRMELDTPSDQRVLEEIRSHDLGKEVTFIKELIANSKSPVVFSHNDCQEGNILLAKGSPEIKDNSLVLIDYEYASYNYRASDFANHFCEWTIDYTKESAPYFNLVPEDHPTEAQQLRFIRAYLEEYNSTKEQREGEGPGAGGEGVCNRMSTEAEEKLILREIARFTPVIHLIWVMWSCVQAKISHTAFGYMEYGLARLKEYFRTKAALPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRF1</accession>
    <name>A0A913ZRF1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054342.1">
        <property type="nucleotide sequence ID" value="XM_038198414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054343.1">
        <property type="nucleotide sequence ID" value="XM_038198415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198414.1">
        <property type="protein sequence ID" value="XP_038054342.1"/>
        <property type="gene ID" value="LOC119726652"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198415.1">
        <property type="protein sequence ID" value="XP_038054343.1"/>
        <property type="gene ID" value="LOC119726652"/>
    </dbReference>
    <dbReference type="GeneID" id="119726652"/>
    <dbReference type="OMA" id="EVKTHEN"/>
    <dbReference type="OrthoDB" id="10565663at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="34854" checksum="A083085AB2A28C31" modified="2023-02-22" version="1">MMLEAADRSFEMTHEIAQQEEVKQFICSGNRREEYITTATTIKKTISMTSPATEEKLLGVTASPTVPLAATACIAGNHGLRETRPARRRRHRRGRTLHRHRLSKHRRDQRARCLKRVIGAPRNNNEFLMSQYDEGLILQEAPISNPKPVHQFDSENERLFYTCLTSALVTGGTDGNLTCSFLTPTRASPSSCGSSPSDYSSLPSSPDEDSGCHGYKDIFFASCGCEQPERTDEEETGCAGVIMDGTDADFLRRNFEEEYANNITRGLEEASKEELVSKCMVLMERLRHLEHGEVTRIARDHVRRSELLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX64</accession>
    <name>A0A913ZX64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055880.1">
        <property type="nucleotide sequence ID" value="XM_038199952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX64"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199952.1">
        <property type="protein sequence ID" value="XP_038055880.1"/>
        <property type="gene ID" value="LOC119727876"/>
    </dbReference>
    <dbReference type="GeneID" id="119727876"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="212" mass="23650" checksum="E5924C5E59288091" modified="2023-02-22" version="1">MYRETTLFGKTTTSHFGLMASGSGDLFGRTHKGTTIKFTPITSTDTVMKYGVHFNVNTRHQVITAMKIYENKSFEELRMEDYTANRKGPGSTGLLGQGMTQVDSKASGLFDKSKASSETSFCLDKIEFQAKTQSFEDKRSLFDKSPASLSGQTSTTRTHRGLCGARTGRLFAFGSGSTIKSKRVTRRSGRHTKVRTTRQEYENKGFELYPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A011</accession>
    <name>A0A914A011_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038057162.1">
        <property type="nucleotide sequence ID" value="XM_038201234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A011"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201234.1">
        <property type="protein sequence ID" value="XP_038057162.1"/>
        <property type="gene ID" value="LOC119728833"/>
    </dbReference>
    <dbReference type="GeneID" id="119728833"/>
    <dbReference type="OMA" id="HKRYGWL"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000036">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2Q-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="174"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="345" mass="37631" checksum="1CE618F585565479" modified="2023-02-22" version="1">MAAGLSKLLRQSNRAPPSARRKRHSFSRVRKLRIGNQDSTTSTENSITLPAYSGGVGGGGGTGGGGGSGEGGGDGGARERIVARDEPDIRREMNSVRFSDDSHGTTDDQHMTLPGMIPADHPSPPQPSVKAKVAPILKQKSSASMLKFKPAGQGISSSDLEDIPQPTRKYVSNVRTRRVMKEFEAANRMSQSEDTLFEISLVSDNLYEWCIKLLKVDPMSELHSDMKATNTASIDFNMTFPDNFPFSPPFVRVTTPRVENGYVLDGGAICMELLTPQGWSSSYTIEAVIMQLGATLVAGHARISQNKKKPFGEIPFNKQEALESFNNIVETHKRYGWLDPPGEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0W9</accession>
    <name>A0A914A0W9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057245.1">
        <property type="nucleotide sequence ID" value="XM_038201317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0W9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201317.1">
        <property type="protein sequence ID" value="XP_038057245.1"/>
        <property type="gene ID" value="LOC119728883"/>
    </dbReference>
    <dbReference type="GeneID" id="119728883"/>
    <dbReference type="OMA" id="YIANCVD"/>
    <dbReference type="OrthoDB" id="6572371at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="214" mass="24042" checksum="74C6CB2F442E5599" modified="2023-02-22" version="1">MMPLITTCCACWELRQGTFVSCAYSLIYALVAVGLSAYGIHSYLNYYGNGFRTLSNDTALSTGLGMEQRVLYVANCVDIGLYAVLILSVILVILGVKKLQRFLFIPYLVTMGMLVVLQFLVCLLSVITMFMSHGPQEFVELFLAVVFFVVDLMCWVCVFSYYQEMRDGRAQIRANYTIRVPEISQSEKTEVTIDTSRSFDGPPAYTALYPKPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A137</accession>
    <name>A0A914A137_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057363.1">
        <property type="nucleotide sequence ID" value="XM_038201435.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057364.1">
        <property type="nucleotide sequence ID" value="XM_038201436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A137"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201435.1">
        <property type="protein sequence ID" value="XP_038057363.1"/>
        <property type="gene ID" value="LOC119728971"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201436.1">
        <property type="protein sequence ID" value="XP_038057364.1"/>
        <property type="gene ID" value="LOC119728971"/>
    </dbReference>
    <dbReference type="GeneID" id="119728971"/>
    <dbReference type="OMA" id="NDEYPVE"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="478" mass="51171" checksum="0B6378FC3DA3CE4B" modified="2023-02-22" version="1">MAESHSFTGLSSFVKRYHGHFMVIIVFLQLFTATGPAYTYSILFVSVQEEFAAGAALTVHIFHSFMKTGKRLCLNWWVGSLASALIFCSPISPVLIKRLGPRVVAMLGATLLTCGLVATSFVPALAYAFLTFGILVGVGGNFIYQSGVKVILDWYPRDNCSRATAGAVLGTSVGILAFAPLLNALIATYGWRNALRIIGGITFVLSAACGAFIASPTEEKTRENGVEEGKDASTDAASEVVANNSTEGATFQRTLARVLLRADTWLWLIGFMLSNLGWTFFIINYASFTEYDRGFTPDQVTVSVVLAAVGEILGKLLFSIFGDRLPCLKIYAVAVTGILGAVASGLVTVLYNVTAVYTFSFLLGPVRGVSYVSPYPAAMEIFGDFGSDLVTVLLLVPIGIGLFIGGPLTGGLFDLTGDYTLSLIIVAAILVCSTVSLMIIPLKKQLETRRVARNLHRASVDDFKIPAENPVAGESLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A277</accession>
    <name>A0A914A277_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057750.1">
        <property type="nucleotide sequence ID" value="XM_038201822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A277"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201822.1">
        <property type="protein sequence ID" value="XP_038057750.1"/>
        <property type="gene ID" value="LOC119729237"/>
    </dbReference>
    <dbReference type="GeneID" id="119729237"/>
    <dbReference type="OMA" id="LIRFRYC"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15064">
        <property type="entry name" value="7tmA_5-HT1_5_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="72"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="497" mass="55881" checksum="9222B5A56B64B751" modified="2023-02-22" version="1">MITLKNKSVIAVCDCCTSRATMDGSTTAILYSTDLNISSNLSGTTDLTVHFTPREWLLLVGLSLMILCVIFGNILILVAVFKHRPLQTPPVYLIASLAASDLMVGLMVMPISLTQELTVEWKFGVAVCDIWISLDVLCCTASILNLCVIALDRYWAITKPLKYKPKRTPSRMLIMIVAVWVISIMISTTPLFGWRTEIRDPLTCMISQNQVYTIFSTFGAFFIPMTIMMVVYARIFVEARKRIHGKKNLVQTPLGSSCGSPGRRSTADFPRKISSFLRRISTSEPMIDEMSSTSNVSKKPVTYNSRRRKSSPGLPIADASILQSPTHVRSPQRSSIHNSYTSLAVKQSQDQGSQLTLTVPCSPFIQQRIMQRRNLASAREQKAVKTLAIVTGTFLVCWLPFFINALVIPFCPQCHLPAFWNSLFLWLGYFNSMINPILYTKFNKDFKDAFSKLLHCPKRHNSTHRRVPMSPYRGVNGSRRLSHSHLPDTNGLRESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A428</accession>
    <name>A0A914A428_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058131.1">
        <property type="nucleotide sequence ID" value="XM_038202203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A428"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202203.1">
        <property type="protein sequence ID" value="XP_038058131.1"/>
        <property type="gene ID" value="LOC119729585"/>
    </dbReference>
    <dbReference type="GeneID" id="119729585"/>
    <dbReference type="CTD" id="389161"/>
    <dbReference type="OMA" id="WCRSSHI"/>
    <dbReference type="OrthoDB" id="8856820at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042788">
        <property type="entry name" value="ANKUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46885">
        <property type="entry name" value="PROTEIN ANKUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46885:SF1">
        <property type="entry name" value="PROTEIN ANKUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="676" mass="76126" checksum="F738B2CDCCBC4B52" modified="2023-02-22" version="1">MIRISALYNKRRLPLDVQVYETVHLVKDKVVDLFRIDTKSSSEKKYIVLSYHGAELQDDWVLSEIGVNAGSTLKCSLREEVTPKLFVRCSFNDEVIEIIENLDFASSMVAELRLWITRKIGLPVTVYRILTSSGQEMFDSNLLSQYGIEVGTTLQMETIDGWNEFLKSAIIGHTQQVFRNLNQTDEVICKFQMRVALFVAAHYGHMDLATAMLKNGLRADEKVGDHPSKEWCRSSHIEAYKTPVHEAAEHGQLSILRIFVFNNICVVHSKDGMGLTALNVALRKQQKEVALYLLTKQWANVQFSAMCLPLTVYSAIRRWCDKAKDKVLLVHGLEKSSMKYRKSTHLPGALCGQGVHVDGYTESLMNSCPKSRTLDSLKAKNLELARRGTQLSLTDNQQRSTVERLPRLCGTKTPSVVSRYRNKYLSKTKEQHSNVDPLPRPRSRSVADTSVVLPDIPFNQHKSRRASSDAETFREGRDTESYVDFTRSERGNTAYIRTAGGTGSGAGRFSQGKDVASISDQKSNASMKSDKPTGTERREIERKRRNRAASLDCSIPLLPTSGERVWERPFFYSSSDKSIPRSTIDLYEGMTGSTTWERAINAITVTSSFKDKSWLYRVRMAMSLSETQVKKLGSNPEEDRVENSKRPGMGKARVGSESRQGTNSAISIRRTQSVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4I1</accession>
    <name>A0A914A4I1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058733.1">
        <property type="nucleotide sequence ID" value="XM_038202805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4I1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202805.1">
        <property type="protein sequence ID" value="XP_038058733.1"/>
        <property type="gene ID" value="LOC119730014"/>
    </dbReference>
    <dbReference type="GeneID" id="119730014"/>
    <dbReference type="OMA" id="VITRCEH"/>
    <dbReference type="OrthoDB" id="10151697at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409854" description="IgGFc-binding protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="3">
        <location>
            <begin position="139"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="550" mass="60103" checksum="7069816074422C67" modified="2023-02-22" version="1">MTRFSWFASFTASIIIALIPVVNGQLNITEPGRRTRIYGQDFVVVIPLTTGLPEFGSSLQIACVACQSSSATGRITLLQGNFSKSFSVEATSPNFVSLSISELQLLATTTPPTPAMFNITADENITVTVLVKIAGTLNAYTAFPVDSLDGYYIVASYGRLEEDVSELTVVATEPETYFNLHPYSNVTILGHEDWPATMQFRRGIGGWVTYQTTDSFMGGHIQEVTNKPLIGIVGTHRASAEYGWAQSLDQLNPVVSLGTRYTAVPVAGNHLRNIFRIVPVWENTNITWISGQQSSGKYRHESYILNSGQNHDMSCGPYEIGQIQGSKPFLLLHHIEFETPVVDTALVTVPPAEQFTRQSFTFSTYELDTKVDTYITIVAPCKHSEQIWLQETAGRGRASASKVEKKRSVVGGEYCGSNRKLNAGVYTIGPDPASPSEAVYSAILYGKTASGVFAYILASELNQVTCSVKDTEVTLCHPPRVPIQPALTTVQTSTAPNKNNSNVFGAVVAVVIIVAGLAILGFCLFRYYRSGRWKRSGITMRDKPIVYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A536</accession>
    <name>A0A914A536_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058830.1">
        <property type="nucleotide sequence ID" value="XM_038202902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A536"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202902.1">
        <property type="protein sequence ID" value="XP_038058830.1"/>
        <property type="gene ID" value="LOC119730129"/>
    </dbReference>
    <dbReference type="GeneID" id="119730129"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF144">
        <property type="entry name" value="RASGAP-ACTIVATING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ras-GAP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="245"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58813" checksum="8DE7BBC0B843F4BD" modified="2023-02-22" version="1">MSTFTSESDINTLFRGNSLATKCFDQFMKLVGMPYLLETLQPIVDTIYEEKKHVELDPCKVGSIRRRVSMKNRSEGYLLEHSATIITEYLASIVNCILVSVDRCPPILRMALKQLRQRVESKFPDNDSECKYLCLSGFLFLRFFAPAILSPKLFFLRDQHPDKYVGRTLTLLAKAVQTIGNLGIKSGKEHWMQPLGPLIQDSVSRIKDFLDTLLDIEETESAKHEFAIAVPNREAQKRSIFHRTVTIKEGFLKKRRAEDVSVITPFTFKKRYFWLSYDSLSYAKHAEDQVRNTILMEWVCIVECVDEAAFQSDHLIQIIYHDAQGGLKTLYLQAKDVNEQQQWLSAIRKTCVSNAKMLHTFHPGAFRGSKWTCCLQSSRTPYVGCSRAHNAATLGDWRDPLDPDVEAQIIFSQLRLGKDVLRKKYLEESDAGSAVLRGDPEEDSGNGTEDDINSAAVVTNSDNGAVRPHKPCHKTVSYHDSRMASAATLIDVINDLEKAHLAFERRALEAKQEKDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A610</accession>
    <name>A0A914A610_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058841.1">
        <property type="nucleotide sequence ID" value="XM_038202913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A610"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202913.1">
        <property type="protein sequence ID" value="XP_038058841.1"/>
        <property type="gene ID" value="LOC119730137"/>
    </dbReference>
    <dbReference type="GeneID" id="119730137"/>
    <dbReference type="OMA" id="YWFISRT"/>
    <dbReference type="OrthoDB" id="10025474at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="683" mass="77064" checksum="E5F3BA9E22B88C40" modified="2023-02-22" version="1">MTYSSSVHEHNNNTVFFSDNPNLQETLFLHIYFVVENLIMFQSVRVAVSFIVALLVSKMVGSLYGTSVDHDRDIEHTIGELNRRIAGLQVQRSHAYVPPVFWAKDRGVYESNIRINTYGKPWIAGFRQVGVFDNNAFATAWVTICLLEAGQYGKGAPVPGDEPMKRALELINSHHDKNSPPGNGAVDFWPQTLNHSSGLWVSQPTNIISIISLLDDDLPWDLIEKVCSILGPSSEVCELLKFLQGARQELFPAFKIPADFDDTFVNIGLGSLLKQLSKRYPVLYQLWESNNTNTDSAFELLKTYAYRPLSDDLANVIDPRTYYYAHGFLEKANDEGKPVSLVTTWIQNLTEERVRHNEGVSMPFNINNVDSTVAANVIYGVNAALLENMFETKTWFDADTRMVYENTTSFIAWVIESGTMTSRPDLALTYYPSRYNFYWFVARTRFLIANRIARGDLPAFPSLRLVYEQLNEVLQSRVTTDILAEAKTEGGKWAYFDDFLGGADETWEGKPKNSADDRLFTTSMAVNTLIATWTTQDEVTGQLTWAKDTPVDVIRVVDQAVSWLAEFILSDDYKPLNAFFSGSVKGTSTMPFYYPINFLEYVNGTKIPLNDTHIDLDSSVVLAMSGVVPHEQYKKMVQEPHFGHQTPTEFPGYSNSVFPFWSSAAYTYASTLLTLSQFLNLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7H9</accession>
    <name>A0A914A7H9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059743.1">
        <property type="nucleotide sequence ID" value="XM_038203815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7H9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203815.1">
        <property type="protein sequence ID" value="XP_038059743.1"/>
        <property type="gene ID" value="LOC119730783"/>
    </dbReference>
    <dbReference type="GeneID" id="119730783"/>
    <dbReference type="OMA" id="IVDCDAP"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056073">
        <property type="entry name" value="DUF7656"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24676">
        <property type="entry name" value="DUF7656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7656" evidence="3">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8206" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1210" mass="136833" checksum="5D8A3AB14744F36C" modified="2023-02-22" version="1">MTVFLSGFMISGRFCDSPGGFGIPASCLALDPGGFGIPGDTLFGSKLEEDAVDTTDLGDTSIELVMSDNLQEKFSKLNVEAELQVSVLAGLIKLSGSGSYLGEQRKSARAQSMSLIYKLRTVNEEIMLRQNKDKIDLEILAPSNMQTVDATHVVVAIDWGAVCSVTCEYENKEDKNVTEVKGDLSAELDQLQVLVDIKGSAKASYDDKNKGNHKKFNFKCKADVSASDKDLPVTFEGAVELARNLPSLVKGTNKGKGVPLLYALKRLDAVVKMCSLEIQLQIQYTSINDDIIKKCAHVVEVITKKRQFLYDIQNDLHTSGEFVAERSLARIDDTLNEFIVQEAGFKSRLQDLVKKVRSGIVDVSKIEAFLDKEVSGAFSISGYNDHIREFQNDVNKLKSIKSWKKKGIIYIGKKYEVTVDDSRMVYVLYKTGNENVKNDLDEKNLEFFLRLQKTHAHDEDYKFIVVDQDLREDIWPSGEKKTTIHSFVNGAQTSVDLYAKEGEDSEMCLIKITEPVYQQMRPHNRAYVQIRCPNALGENGQCSGDPVTWKCYKCRESVEYGIEDKLFHCKCGKSEPNKSFWRCYDENHGKIYVKYPHDILSAELSNLRAIKELNILILGETGVGKSTWINGFINYLHFANLEKAMHAKEFQVLIPSSFTFTQHGKQKKIMVGESDTNENMEVGKSATKEPRSYVFRVGEEIVRLIDTPGIGATEGIQEDKKNFDNILSHLTFYEEIHAVCILLKPNNARLTAMFRFCIQELLAHLHSSAKDNIVFCFTHARGTFYQPGDTLPILNRELRDKQVGIQATPSNYFCFDNEPFRFLACVKSGVEFSQGEINAYAESWNWSVAETNKLFKHISSLRPHNIRNTLSMNEARRIIVAMSKPLAEVAKTIQQNVQEGNEAKTQIDLVDRDMDSLKANLKFSGFDLKRVELSYPRTVCADLKCVRYVPIGASRMQNTIYEQQCHPHCGLSGIPTQTTNDARLQGCACIRGTNCTKCGHHYTTHMHMTYDLQVFSMEFLSEEVQTQINQKKSAIETKKAFKEAIDTKNAELKKEENTIVKTSAKYGSFLKANALIPYNDAVGDYLDMSIEQERNKSKAIRNDTLLTTMEDMKRQYEYERRILDQAIDEDGGENIHTPEEVMKLQKELFGLKHMGQTLKDLFDGISISHSARNIAFQETTAPIPQKYKKKGAKSTWNFSFSMLQWLPFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7J5</accession>
    <name>A0A914A7J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059832.1">
        <property type="nucleotide sequence ID" value="XM_038203904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203904.1">
        <property type="protein sequence ID" value="XP_038059832.1"/>
        <property type="gene ID" value="LOC119730851"/>
    </dbReference>
    <dbReference type="GeneID" id="119730851"/>
    <dbReference type="OMA" id="ENAFMAT"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="28234" checksum="4C3848A146B3B5BE" modified="2023-02-22" version="1">MCGARVIPVLGVSFAFVVMICLDFCTLPSAVEECPPLWIPWGSSCYRLTGQGASWDEGQACCRDMGAVMAAPFTDEENAFMATTTKNAGLDWLWVGCKFIDRAWRCEGQEVGQAYSNWRPGEPGNKDGGSMPYTDYCAYVIPTSLDWNDSPCTERPKAMCVLRSPAHIRHQGFSRGNAQQQQLNWCLVDHVIREFVTKSASRCASACLKEPGCRSFNIKGTKQEQKLCQLNDAVRADSLEKFQEVSTQCVYYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAC6</accession>
    <name>A0A914AAC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038060723.1">
        <property type="nucleotide sequence ID" value="XM_038204795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204795.1">
        <property type="protein sequence ID" value="XP_038060723.1"/>
        <property type="gene ID" value="LOC119731600"/>
    </dbReference>
    <dbReference type="GeneID" id="119731600"/>
    <dbReference type="CTD" id="253430"/>
    <dbReference type="OMA" id="ATDEFEC"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051765">
        <property type="term" value="F:inositol tetrakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="525" mass="57361" checksum="064F7B5E7A01642D" modified="2023-02-22" version="1">MSSEAVAGAELQSSGGTEAVLNGAVAASGVPSARAAGDDGSLDRECESLTKNAPGGGQNATQDRSNGVITPPLPKGCVPLSHQVAGHMYGKGTSKAGLLQDGMGTVLKPGQNACRGKRERTFYHNVTRPDQSNPLYTSLRPFVPRFYGTFVSPEDPSLVYLKINDVTLRFRKPCVMDVKIGCKSYEDGVSLRKVELAKEKYPNLEKIGFQILGMRVYHPATDEFECRDKFYGRSLQGDNVIEGFARYLNVVDDVRIDVVPEFLKQMRRIERWFTNQKQLNFYSSSLLFVYEGAVTPSPSQPLTETVATPENDGLSNSQPVPNFVSYSQLKRVGPKSKQSASAVESLPPDSNVFPEQGEHPPEENGFVNRLPTYQESIAAKLGHKGGTGPVEGGLSNGAEGAISNGGQAEPQLLDINGRLTVSQMRERQRSLSNGQSDSPSQPEQPEGEPMTVADVHTDQFQPIEAADVSADQIDEEKESDSKLALVKMIDFTHVVDADRTDENYLFGLRNVIRYFEMLLNVYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAY4</accession>
    <name>A0A914AAY4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060606.1">
        <property type="nucleotide sequence ID" value="XM_038204678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204678.1">
        <property type="protein sequence ID" value="XP_038060606.1"/>
        <property type="gene ID" value="LOC119731505"/>
    </dbReference>
    <dbReference type="GeneID" id="119731505"/>
    <dbReference type="OMA" id="CAPESNI"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037848920" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="142"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="260"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="12">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="869"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131137" checksum="7897D5CE2B08BB30" modified="2023-02-22" version="1">MELAHLLYALAVTVLGCVCFGAVSAADIIRLRLADGRYPNEGRVEVLPAGEDSWGTYCSNDNPFHVGRVACRQLGFPALLSATATGEFGKATGPIWFQQISCSQGAQPVVTLNDCSTSGWLPSYVVCDHRFDVGLTCFTGNLRLVGGRSETEGRVELHIGGDEWVLLSFRGGTNFMYSDSVCQYLGYQFSVGVTREPAVNNNQKILCSFSHCPLYDGSRGFFQCLDELSLDLCTDKNITLLGAVCATETDVLPSDASFEYRLGYTSNGSQYMGILEARYNGSTWATVCLQVVNVYRAGIVADQACRSLGYPWAFVSKLIPYSESPGYVSTGEELIMRELFLGSAHGEAQWVRGQNACQRHEYELLHVECETGVTMYGLTVFPCSKQTCLGRCGSPATNELCGCDAVCSQCNDCCYDYKERCSLHEDPDNHTSLSLGSFTCRIVDRNRVVVVDGCSPGWNDTQVAQQCANNSYPGPIKYQEGIFFNNLLCAACNGFSFESSDLSSDLSSDLLNDFSFYQIEEYDAGIDECPLNYVNLEIALGCQSYSAIIATSDWLMYKNPHCAYCNGVNISTLDYCPLVRSSVFPAHFEVLLGRVPEPWAPEASTSLQLQDEIKCHNKHYLLHVLPTHRGNSSVMEVTQCYLNTLGWQNIQLTWPFYSSFIDHQQQAFAGEMTKLITEYVTNITDFEEILDLTVVPPYEEGSSREWIVRCGVEQVDFVEVCGTAENVTINGTVTELHCEHSTFTARAADTRVFSMGGVQVIYVGGGVFVEAKSVSFFRSYNYPMAVFNGSAKDTRVSVCGQTFKNEECRLLRAGETKAVRTEDGEPGLEYKGRKFLQDQVTYLPDGWILICSSIFSALQEPYISFSDPLTVVNFIGYCLSVVALLVTFTNYCVFPVLRNVPGSAIMSLTAALFLAQLLTLTVLDKAENQTFCISMAVLMHFLWLATFTWMNVLAFDLMRTFTSRQAARPNKRVFFTYCLYGWGLPLLAVTTCLVIHFVDGQHVGFQYGGEQSCWVIGKYAVLGAFIVPMICSLTANAVLFGLTVRSVHASLAAAAMVRQDKSKSRETLGELWIFFKISCVMGFTWLFGCLGSFIDHQAIWYVFVILNSLQGVLIFASFGCNVRIRNLWRDKLGMEARRKNKKARNSSNISSSATRRTSAECRAQTMASESSIRLQDVQVSTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABS9</accession>
    <name>A0A914ABS9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060916.1">
        <property type="nucleotide sequence ID" value="XM_038204988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204988.1">
        <property type="protein sequence ID" value="XP_038060916.1"/>
        <property type="gene ID" value="LOC119731747"/>
    </dbReference>
    <dbReference type="GeneID" id="119731747"/>
    <dbReference type="OMA" id="CASITIV"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF11">
        <property type="entry name" value="FUCOLECTIN TACHYLECTIN-4 PENTRAXIN-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036998516" description="Fucolectin tachylectin-4 pentraxin-1 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="206"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="37474" checksum="7EF2DE3F4984BE33" modified="2023-02-22" version="1">MFRWVAAAVLVLGLVGFQIADAMNEDEMELLERMLERAEEKKVAGGQPLSIVGKVTWQSSSHGSFLYPSSKAVDGSSSTVMYPDAKCSHTVSNSENPWWMVDLGGEHCISKVNILNRGDCCSERLQGANVRAGNSPTATDNPTCGSAVTAAQAKPLGGTIQMDCPTPLRARYISVDIPRTGTLQLCEVTVEELSLDQCETEAFSIVDHPASQSSEQGSGRYPAGKAVDGSSSTIMYPDAKCSHTSQEENPWWRVDLGGEECVTKVTILNRGDCCSERLQNAIVRAGSNETPIGNQACGAPITAEQAQPLGGTIAVECGRPLRARYVSVDIPGTAVLQLCEVYVEVHSSGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD51</accession>
    <name>A0A914AD51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061673.1">
        <property type="nucleotide sequence ID" value="XM_038205745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205745.1">
        <property type="protein sequence ID" value="XP_038061673.1"/>
        <property type="gene ID" value="LOC119732285"/>
    </dbReference>
    <dbReference type="GeneID" id="119732285"/>
    <dbReference type="CTD" id="55735"/>
    <dbReference type="OMA" id="QLDKHTM"/>
    <dbReference type="OrthoDB" id="18010at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="562" mass="63165" checksum="50BBF1D71ED3B5F7" modified="2023-02-22" version="1">MAAPMLEEGLINSDDYYAILNTRKEASSDELRAAYRRMCVLYHPDKHRDEKDKTAAEAVFNKVQKAYQVLNDPSKRAIYDVYGETGLEAEWDIVPRRRTPQEIHDEYERLAKEKEERRLQQSTNPRGAITVGIDATDLFDVYEDYDMEFSGVPSIEVKNMSITQSIDAPLTPTDTAVLSGNLSTQNGNGSGNFNVAYRRIFSYQSWGEFQASAGGGPTLALKIFRNINKRSFVSCTGSARLLSGTVIAPGIATVAGRQLDKHTMGYMTWRWGMASSMTTMVVRDTQSTHTMCQMQLGIPNSFVSVSFTKKFPEHDGKITLAAKVGLLGSVFEYGCDKKISRHSRAAAKISIGIPAGVTLRLRLARGNQTFLFPIHLSHELSPQALFYGTVAPLLAYWFIKVLVVDPFLNKRKTDELAKERDSKQEMMDLKKQEAQDEVHLMQEMVQRIVETERNREGLIITRAWYGKLVIREAEEENGDGEVGGEIEGMIDVTVQLQCQVKDSKLMLTDASKAALPGFYDPCVGEEKNLRVQYEFHGEQHECTIADNEPLRIPKRSHHVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADC1</accession>
    <name>A0A914ADC1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061738.1">
        <property type="nucleotide sequence ID" value="XM_038205810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205810.1">
        <property type="protein sequence ID" value="XP_038061738.1"/>
        <property type="gene ID" value="LOC119732352"/>
    </dbReference>
    <dbReference type="GeneID" id="119732352"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="192" mass="19503" checksum="940137EDB8F5B9D4" modified="2023-02-22" version="1">MACRILNSLGAVGAVAIIVTAALITSTNIVTDSDAGAIGAAIATAVLGVLELILCFLAGTFSSRILQSAAAMEAATVAYSGGGVANPGMQYPEAHVQIQYPAQPPQGQYPGAPDQGQYPGPPAQGQYPGPQAQYPGPPAQGQYPGPPAQGQYPGPQAQYPGPPVQGQYPGAPAQGQYPSAPVQYPPTEEQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFK4</accession>
    <name>A0A914AFK4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 58</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062755.1">
        <property type="nucleotide sequence ID" value="XM_038206827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206827.1">
        <property type="protein sequence ID" value="XP_038062755.1"/>
        <property type="gene ID" value="LOC119733241"/>
    </dbReference>
    <dbReference type="GeneID" id="119733241"/>
    <dbReference type="OMA" id="GLSQWFP"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF53">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41086" checksum="73D8CB79B8A51F71" modified="2023-02-22" version="1">MCRLRFVMEHSGPSDSAAVGSVQLAKAVLSRKQLSDFPEDEFSGQEHKVNIIDLSRNSLSSIPGTISVYTNLIELDISNNRISGIPDEIVALKHLRSLICKNNQLETNSLPKDFGKCVSLETVNFSGNTMLDFPMQFTEIQTLKAAYLGGNRIRQIPTAIQNLQRLERLYLGGNQLTSIPLELGSLPRLACLVLSDNRIETVPSELVNLRSLKSLSLHNNRITTLPPQIISLGDLCELSLRGNPLVVRFVRDFTWQPPSLLELAGRTIKNRGIAYTAEDLPLSLIHYLDSARHCLNPKCSGVYFSSRVEHIKFVDFCGKYRLPLMQYLCSPSCTSSSSGNYSSSSYTSSSDTESDEEAAVPSNKMKKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGI9</accession>
    <name>A0A914AGI9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062504.1">
        <property type="nucleotide sequence ID" value="XM_038206576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGI9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206576.1">
        <property type="protein sequence ID" value="XP_038062504.1"/>
        <property type="gene ID" value="LOC119732994"/>
    </dbReference>
    <dbReference type="GeneID" id="119732994"/>
    <dbReference type="OMA" id="REDIKHQ"/>
    <dbReference type="OrthoDB" id="10018421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="458"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="867" mass="98069" checksum="2388E55C2149B530" modified="2023-02-22" version="1">MAVPVDPVPQNVPQNAPQNAPDDDDALMLVVVMLLMMLLLVLTKADDDDALMLVVVMLLMLLLLLVLTKADDDDALMLVVVMLLMLLLLLVLTKVILSSLLSSLYGELVTNQVRLYERTSIRRSKLINNLTFLKRCRDSKITPAGLRIRDPIRNNRSEDILRRASSALIRERISFTRLQLAILDQQITDTEEDLRSTLEPVHFDRICSLTTSSSQFVFSTTRQKQLRKFYRLERKERNTPTPFHRNRSPPTGSPISWRHPSRLHSPPTGSPISWRQSSRPRNLPSGSPISWRHPPHLRSQDTFTKHTVVNLSNRQLNSTETKVLSLGMNFAVPPKSVPIESIIQSTEPALRHLTKTAANDVRIKMNEVLRKARPAKPNLTKTERFAVSDLRRDNSIHILAADKGNATVVMDREDYSNKVKDILSSGSYRPLPKNPITAIEKRVASQLLLLHRADAVSTPLYRRLRPSSSICPRFFGQPKIHKPEIPLRPIVASRGSPTYHSAQHLAKILRPLVGQTPHHVSNSPQFVSITRNLTVKPTDLLVSFDVVSLFTNVPTGEACKLAKERLEHDTTLAERTDLSPDQIHDLLLTCISSSCFQWQGKFYEQTAGTSMGSPLSPVLADIFMEEFESSSLLTADLRPSLWLRYVDDTFVVWPHGPDTLQDFLQYLNKQHTSISFTMEQEQHVTIPFLDVKISRNPDGTLGHSVYRKPTHTDRYLHQRSFHHPSIKSSVNRTLVQRAFEVCDQDNLKRELKHIQTSLQWNGYKPNRIKISKPDQRVPFTQGPPTVSPSVTLPYIGPASHHLQRILRQAGVKVYHSSGNKLQGSLHTHKDKQDSSSKPGVYRNPCECGKVYIGETGMPLEAVELIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHA3</accession>
    <name>A0A914AHA3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063097.1">
        <property type="nucleotide sequence ID" value="XM_038207169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207169.1">
        <property type="protein sequence ID" value="XP_038063097.1"/>
        <property type="gene ID" value="LOC119733800"/>
    </dbReference>
    <dbReference type="GeneID" id="119733800"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="111" mass="12680" checksum="E602292EB9336DCB" modified="2023-02-22" version="1">MATAMDVDPPSSSSGSSVKGEKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI89</accession>
    <name>A0A914AI89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063436.1">
        <property type="nucleotide sequence ID" value="XM_038207508.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063437.1">
        <property type="nucleotide sequence ID" value="XM_038207509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207508.1">
        <property type="protein sequence ID" value="XP_038063436.1"/>
        <property type="gene ID" value="LOC119734163"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207509.1">
        <property type="protein sequence ID" value="XP_038063437.1"/>
        <property type="gene ID" value="LOC119734163"/>
    </dbReference>
    <dbReference type="GeneID" id="119734163"/>
    <dbReference type="OMA" id="VWIDTDM"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015910">
        <property type="entry name" value="I/U_nuclsd_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01247">
        <property type="entry name" value="IUNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="317" mass="34460" checksum="7F7FB766B28BE4C2" modified="2023-02-22" version="1">MAETLQMIIDCDPGTDDAVAIMMALSQPSIDLLAITCVTGNTPLNNVLHNALRVLRVCNRTDIPVYRGADKSLLDLSYTTAHDVHGSDGLGGVVDPDPPSLDLVQSEHAVHAMLRLTKERPGQVTMLAIGPLTNLALAQRMDPEFTGRLKKLVIMGGNTEGTGSETDAAEFNFYTDPEAAHIVTSEVQCPTVVIGWETCINNGLPWDWFDKWSGTPTAKGKFVSAILHGSFVAFEQSRRALFKVCDALAMAVAIRPEMVLEAVTCPIMVELHGHVTRGQMVQRIKNTEGLPLGPTVEVVIRCDTEILKQLFEDTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK22</accession>
    <name>A0A914AK22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049743.1">
        <property type="nucleotide sequence ID" value="XM_038193815.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064082.1">
        <property type="nucleotide sequence ID" value="XM_038208154.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193815.1">
        <property type="protein sequence ID" value="XP_038049743.1"/>
        <property type="gene ID" value="LOC119723251"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208154.1">
        <property type="protein sequence ID" value="XP_038064082.1"/>
        <property type="gene ID" value="LOC119734618"/>
    </dbReference>
    <dbReference type="GeneID" id="119723251"/>
    <dbReference type="GeneID" id="119734618"/>
    <dbReference type="OMA" id="NEIGMQV"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="475"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="146950" checksum="2C0A5D72036D259B" modified="2023-02-22" version="1">MATFGNIGEFCEKKETWEMYTDRLGEYFAANNISDAARKRAILNSVVGSQTYKLISDLLAPKKPNEATYQELVDRLEKHFKPTKSSIIARFQFNSRCRRSGESIAEYLAALRALASDCKFGQNLDEMLRDRLVCGVQNERIQKSLLAQPEDKLDLKRTVELAQSMQLAGDQAKMLSASTSTMAESNTTVNAFKKKQAQRPNRPTWSNQRQTSARSSSTQHQKPRKPCGNCGTFHKRRECPAYGKTCHKCNKKNHYADYCRSSRHVYTVNPDSYSEEDEPAVDEQELFYVRAVDNTNLNLKHDIHATLVVNNTHVPVQLDTGARCNVLPMNVYNVIAPPKSIDNSKSTKLIAYGGTELHTVGLATLPCRIDSSQTDHNIDFHIVDTQVKAILGLTDCLRLGLLSVNNLVYHVSNDTTSPQVFKDYEDLFDSSLGSLPVIYTMTIDPNATPVVRPPRRIPAAMQDKVKSELQRMTTLGVITPVSEPTDWVSSMVATHKKNSEEIRLCIDPRDLNEALKRPHHPTRTVEEVAAKMDGATVFSVLDAKCSFWQIPLDYESSLLTTFSTPYGRYRYLRMPYGLCSASDVYQRTMEQIFADLPCSIIVDDILVGGRTKEEHDRNLKTVLDRIRKINMRLNPTKCRFGLEQVSYVGHVFTASGLKPDPAKVSAITDMPPPNDVTALQRFLGMVTYLAKFVPNLSDLTAPLRELTHSDIHWCWLEQHNAAFLAIKDKIANAPTLTYFDVRKPVTLTCDASKFGLGAACLQEGAPVAYASRTMSDTEQRYAQIEKELLAVVFACTKFHDYIYGKDIVVETDHQPLVTIVKKPLLSAPARLQRMLLRLQRYNITLVYKKGKELFLADTLSRAPLTTTGTETDDLQVMTLLPISDMRLEQLKKATACDSAMQQLTDVISRGWPSHINNAPPKAHPYFAFRDELVLDRGIILKGHKAIIPKSLRAEYIQILHEGHPGIEATKRRARDVVYWPSMCLDIEQSVSGCTVCNATKAHQQKEPLKSYPPPSLPWEHIGVDLFHWNGMDYLALGDSYSGWFDFASLDNTCASTVIEVLKRQFSIHGIPCIVISDNARQFDCFAFKQFAQSWGFQHTTSSPHFPQSNGLAESSVKRAKQLLEKTKRDGSDLYRNLLNIRNVPTNPQLGSPSQRLMSRRLRTTIPTPTPLLKPAIYTRVTAQLRKRQQQQKSSYDKSAKPLRPLTPGQVVRLQSPEGHDQLGIVQKHSRNPRSYIVNAQGTLYRRNRRHLLPVPEPPPQQQHSPDFYLPPQDPLPQPAIPHAPPPQPVLTRSGRISKPNPKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKR4</accession>
    <name>A0A914AKR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064019.1">
        <property type="nucleotide sequence ID" value="XM_038208091.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208091.1">
        <property type="protein sequence ID" value="XP_038064019.1"/>
        <property type="gene ID" value="LOC119734557"/>
    </dbReference>
    <dbReference type="GeneID" id="119734557"/>
    <dbReference type="OMA" id="MANHEFN"/>
    <dbReference type="OrthoDB" id="10072641at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1310"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1369"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1386"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1445"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1474"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1512"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1524"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1543"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1561"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1621" mass="177177" checksum="BD914C514513FC3D" modified="2023-02-22" version="1">MANHEFNNRPSSQLFPAARAMKQTSTTMATGLVPGVNTLTSPVSKQRQVERPMASTPTAQVVGGVSRIASGGRAKPVVAPHSLTEEQVLQQKVFAARLLGLPVDVASKMAASGRNTSNNQGGLVSSSTTPAASAIGRSAGRTRASLTPPPFPSVLQQQQQQQQQHQQMPGKFTTGAASSVVLPISSLGTNPQQQFPPGQQQQFLQGQHHQQVLPQQQQQQQFPSGQQLQFPHGGQQQFAQGPQQQGIQQQQQQAGFNTANVANKSWVGNASQNNVGSVRGAFGKSQQAPPSRSGNTGPGILGAFPATQSFGAPVISNTNQHTSSYGVGPMSMAVTTTYSAPGVAMSSVSSQPPAAMSLKTQFFPNMKKNLQVLSPFEMEKLRKALLSGKTVSLGLTSAQTLDILQTMKSISSSRMEPSARTKKTSDGDWVDPISTNWPGTADEEWKGPEKGTTQPTDKHRGLGAILEVLRSGQSSVSEDKRGGQSTSTPIQGGNTFGPTPIVGPGGGSLTMDSGQVISSINENLKMLQMQREKLLQGQGSVPQKSRDDSDQHVNQRRTSDSKWRSHSQERHDTRHAGDRLGRTRRSPDRLGDRDRDRDRRDDRDRDRGRESSRGERHTSRDRDRRRSLSYSRNNDRRRSHGSPPRRTRSRSRERRDRGRRSPSGERRDRRRSSDRKSLPSQSRHGDSPDRKRRRPVEATGKVDSAGRSSSNSSSSRPNQGVRMPAWYQRKRDAMWNKKPTTDKRDHEKPSATSEKPKEQQQEEEKKPEETSTQPGPSQSIPLSTRPGPSQPIPLLDIIIPRKSAVAMATTARRLAQQSAAMQKLADAKKSADAKKSADANAAKTPSSDPKASVTSSGDKTKKKKEEKKLTEEEASKIAATLKATPLLQQIGESSIQHQLSLLKEVDLEEHVKDKQVVDWYCYICGKYCTGWSIYLSHIEGRRHKATFQRLHEPSHAALRKALITKLGDLPDKHQGGQKEFQNWVNAPVPSFAIPPPVQLLVTSTPLGRLDQAFFCGKCFRTYACTYEEHMASEDHKRYVKIRPKCTLCDLTFLNVKCLRGHMKLLSHIRKAQESELDPNVQQGEDDYNEKEVEMEVEESIDVEDGKEVDSDKNSTKEKADIVGPEFIIPITGFFCKLCSKFYNKEKAAKAVHCRTPVHKHKVKLYYAKRVKSSVASLKASPGAPISEDKVSTTGKTSQERDDGAKTHAPANKDVPATKDPPSKKNATPVKDAPPRKDAAPKKDAASKKDAASKKDAPPKKDVAPQKDAPPQKDAPPKKDAMPKETTAKDAASKKGAPPKNTLPAKDATPSKATTTKQSITTKQGTTPKQSTTPKQSTTPKHGTTPKQGTTLKQGTTPKQGTTPKQGTTPKEKITAKEKTTPSNDTGSKKDAMTINSERDASHVSRKNDRTADRTLTPREKSSNDTTSKETLPRQPIPKLVISIPKMSSSTIAAMNGTNSQTSKERVSKTSTPISATPKSATPKSATSKSSSSEINKEGRKAALTNYGDSKSKTSSGSDAAKSANKSNQKNVASKTDTLQSPTSKEERKESGSQKNKHEESDPLEEETSSTAEEDEEGEWLGEMPDFDNMIFIDEVGESEEEEVTEIEEDEEVFVISDQEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALP2</accession>
    <name>A0A914ALP2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064930.1">
        <property type="nucleotide sequence ID" value="XM_038209002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209002.1">
        <property type="protein sequence ID" value="XP_038064930.1"/>
        <property type="gene ID" value="LOC119735303"/>
    </dbReference>
    <dbReference type="GeneID" id="119735303"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="25004" checksum="EA2AC4C4A80F2CE0" modified="2023-02-22" version="1">MPASSKCPPVSVTYVIITARAASPFIMGITVIYIQSEGKFVISGIPEDDDAGTCLGLEGKLGAPTWEVVSLRPDLDCIQRDGEFLYSDPISTDRFDCRYCRDKVCSSSSFVDIVPIPTPEPNGPTDSKVVVIVAVSVSAGIFFLTLAIAMCYFCKCFSCGKVSPRNELRRNGPQPNPSVAVFNPSCDEPPSYVQAAELDVNAGKNDDEPPPAYDDCASSNAALQATDENEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMB6</accession>
    <name>A0A914AMB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064882.1">
        <property type="nucleotide sequence ID" value="XM_038208954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208954.1">
        <property type="protein sequence ID" value="XP_038064882.1"/>
        <property type="gene ID" value="LOC119735250"/>
    </dbReference>
    <dbReference type="GeneID" id="119735250"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="43425" checksum="FF922A88C576A081" modified="2023-02-22" version="1">MQDPTPTKADVPVSSVYDSFAEKQLLAALYSLICLMGVVGNSSVLLAVILSRKPRTTTNVFVVNLAVADLLSCLNLPIMILAVLSDSREDLLVSESLCAVEGFLLLVCVWTSLNNITIFAVYRAFITRRKNRSRLFNRRRLAALVVTTWLVPFAVGLVPTVMYGFSSYGYDDKLSTCTFSPASEGTGAFSRITTALFYPVQLTVTFASYAVILYTVRQHVGRVDAIPKQPLAVVSGVMSLTSQSRGPQQLVHEEVPGHSQQLRAPTSNLLWSGTHRSLHAHPLPTRSSTDRRQARRQSRRNIDINLSLFLVVFFFVICCGPYPVLLILLGDKSNKVVPFFAAILVSNSCINPVIYTARHPDFKTVIRCILLCRLSKIPMKSAFLRRILSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMV4</accession>
    <name>A0A914AMV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065072.1">
        <property type="nucleotide sequence ID" value="XM_038209144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209144.1">
        <property type="protein sequence ID" value="XP_038065072.1"/>
        <property type="gene ID" value="LOC119735446"/>
    </dbReference>
    <dbReference type="GeneID" id="119735446"/>
    <dbReference type="OMA" id="CQPLEND"/>
    <dbReference type="OrthoDB" id="10580047at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21534" checksum="04AEFF38E94BD844" modified="2023-02-22" version="1">MEVGVSINELSAGVFVTRCLLRERDLRSGMGTSLIWIVASVALICDQGAALKCYECVDVYDTKQESNENCRSNTEALTAEECQRPNGTEPEATPRCMKEVGTVTIEPDTGGAVQEQDVLRSCIWLLPDAPENQCFNAPSEDQPLEEISVVEAHRTDIFDVYALCVCNTDSCNGVGALQSSFAPLVSALASAALLAILRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANN5</accession>
    <name>A0A914ANN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065223.1">
        <property type="nucleotide sequence ID" value="XM_038209295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209295.1">
        <property type="protein sequence ID" value="XP_038065223.1"/>
        <property type="gene ID" value="LOC119735557"/>
    </dbReference>
    <dbReference type="GeneID" id="119735557"/>
    <dbReference type="OMA" id="ANYDSHI"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="222" mass="23560" checksum="1A63A4668B2B222C" modified="2023-02-22" version="1">MAEQTVAVAKPVKPKKKAAPKKKPSHPSAGEMILAALANLKDQPRAGTSLQAIKKYIHANYTLPANYDTHIKRGIKTLVAQKKLVHTKGKGASGSFKVDNKAAKASASQKAKKEKQREKAKQLKEKKKEQNKAKKEKAAAKKAAKKKTPKKKAAAKKPAAKKTAAKKPAAKKTAAKKPAAKKPAAKKPAAKKPAAKKSKPAAKKSPKKGAKKGAKKASKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP84</accession>
    <name>A0A914AP84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065291.1">
        <property type="nucleotide sequence ID" value="XM_038209363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209363.1">
        <property type="protein sequence ID" value="XP_038065291.1"/>
        <property type="gene ID" value="LOC119735597"/>
    </dbReference>
    <dbReference type="GeneID" id="119735597"/>
    <dbReference type="OMA" id="CAPWFCN"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="269"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="56557" checksum="ECDC3CAB38342DA0" modified="2023-02-22" version="1">MFRFVMRFKTRVFVSVGVLLIFTTLSAVHLLKQFEAPEDLEDTNLGFDRRARFGPNNGRANTWNKQETYLLMSKGQISDERHQNDSGGNESQILKPPLPRPRRTEDGSKLKKRQPAWERGSSSKKAWDDQEIVGKGHPWQQFHLDISQDALYSEGALYMDDLLRDLASVRIVNTSMFQGGSQVKLDFRLADGNRAIVKPMRSPREFVYKYNNDEPFWLDQERHNAEIAAFHLDRLLGFRRVPPCSGRLINLTQEILLKSKDQELLNTFFWKDGNLCFIGKCAPWFCNEDHPICAQGHLMEVSMCQFLPSFGGGIPIFEMEYPWSQGVKESQVWKGKNICVDYLKDPVWTRGRFLLDLIEQGIFDFFIRNYDRHHFDMMRKYKRLGTVLFLDNGKGFGNPHVDDTTFLAPIYQCCKVRRSTYLHLKELTQLRLSDRMRSSMSHDPIAPVVTEDHLQAMDRRLETVLQTIEKCIHVHGDSQVLVETLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APA7</accession>
    <name>A0A914APA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystic fibrosis transmembrane conductance regulator</fullName>
            <ecNumber evidence="7">5.6.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">ATP-binding cassette sub-family C member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Channel conductance-controlling ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">cAMP-dependent chloride channel</fullName>
        </alternativeName>
    </protein>
    <organism evidence="34 35">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.</text>
            <dbReference type="EC" id="5.6.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hydrogencarbonate(in) = hydrogencarbonate(out)</text>
            <dbReference type="Rhea" id="RHEA:28695"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.6" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038065860.1">
        <property type="nucleotide sequence ID" value="XM_038209932.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209932.1">
        <property type="protein sequence ID" value="XP_038065860.1"/>
        <property type="gene ID" value="LOC119735955"/>
    </dbReference>
    <dbReference type="GeneID" id="119735955"/>
    <dbReference type="OMA" id="THATHRM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005260">
        <property type="term" value="F:intracellularly ATP-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009147">
        <property type="entry name" value="CFTR/ABCC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01851">
        <property type="entry name" value="CYSFIBREGLTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0868">Chloride</keyword>
    <keyword evidence="19" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="22" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="821"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="973"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="1079"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="33">
        <location>
            <begin position="156"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="32">
        <location>
            <begin position="546"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="33">
        <location>
            <begin position="829"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="32">
        <location>
            <begin position="1170"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00033163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1426" mass="159300" checksum="8F808D4774A081D1" modified="2023-02-22" version="1">MGALFRTDSYAQLPKFCLSRERTVMAAHNVDVSSKTSGYDIKPRHVSDFAQTEDEPVKAPSGVRRPPHPMKTAGLFSKLVFFWMFNFFRRGYKRPLVETDLYDVLPDDSAVIVVGKLEREWNKEIKKSEATGKPSSLRWALLRAFGWHYMIHGLPAFIEVVLKMAQPVMLSRLVLYFSTDLVSTTEAYLQALGMSLSSLLILIAGHFCYFGYWITGMRLRTACSGLIFRKALRLSNLALGETTIGQLVNILSNDVNRFDLAFRLLHYLWIAPLQLTIVVALAWREIGVSCLAGTSILIFMAPLQIYIGKLASKFRSKTALLSDARIRIMNEVISGIRVIKIYAWEHSFGKLVAESRAKEVRKILHSAYLHAIIGALRFDGALLTTFITFIVYASLGNPVTPSKVFPLLALFYSARICLSNNFPFAIMHGSEGLVSIRRIQMFLLMDELQRHVNEPNTDVMDDIFLEEQTALLDEIKADDTLKNDKLDISEHPESAQTNRTNSVIESADNGELVDYLRTAVSEEEEPVETNPHANKLNTGTDVRAQIVVENMYGSWNKDTRNTVLQDVSFRIQPGELLAVIGPVGCGKSSLLAALLGEIPTVSGVNTLNGRVGYTAQQPWILSGSLRDNILFGSKYKQAKYQRIIKHCALTRDIELLPEGDLTLVGERGVTLSGGQRARVSLARALYSDVDVYLLDDPLSAVDPAVGRHLFEKCILHEMRDKAVIIVTHQLQFIDKADKILILQEGKVAGYGTYKELQEDGMDFASLLKKKSEDGDYDGEDKQDVNPERLDDKVSICSDDSDGVETPVGIVPEEMAAGTVEWMVYIRFLVAAAGVPFALVWVIVVVGAQALLSYADVWLAMWTNEEENDLVDRNITSQYYQDGTEYGNRSYYIRIYAILCGATTAASFLRAFLFYHVFVTASKALHNQMFDAIIRAPMQFFDTNPVGRILNRFAKDIGYMDDVLPSTFTEFLELSLGAIATVIVISIFNPFCLAFTLPIGFVFHFTRKYYLASSRDVKRLEGKARSPVFSHLSATLTGLSTVRAFKAQQRFTADFDGYLDGHTRAWFLFLSAARWFGVQLDFLCVLVITGVSLTCILAADLLDLNSGIVGLSLIYAMSLMGEFQWAVRQSAELENQMTSVERVCQYIDIKPEAPLQTDHMPPPDWPQDGGITLQDVSLRYSDDGPLVLREINCAIRPTEKVGIVGRTGAGKSSLMTVLMRLAEPTGTIMIDGINTALIGLHDLRKKVSFIPQDPVLFSGTLRKNLDPFSGHSDSDIWRAFEEVELKPAIEELPDKLEAVLTEGGTNFSVGQRQLLCLARAILRKNKILIVDEATANVDIRTDRLIQATIRRRFKHCTVLTIAHRLNTIMDSDKVMVLDAGQLIEFDEPYVLLQKEDGIFSKVVQETGKAEAVKLLQIARKTSTTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APM5</accession>
    <name>A0A914APM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065394.1">
        <property type="nucleotide sequence ID" value="XM_038209466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209466.1">
        <property type="protein sequence ID" value="XP_038065394.1"/>
        <property type="gene ID" value="LOC119735663"/>
    </dbReference>
    <dbReference type="GeneID" id="119735663"/>
    <dbReference type="OMA" id="QHISCED"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038007963" description="NACHT domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="291"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="665" mass="74678" checksum="E7EB81A8AA592BF2" modified="2023-02-22" version="1">MARKLFVHFLVCVCLALALSSDNTHVELQQGKTGVVHNPRMADKTFNINDIDSAYWHKGLPDGNKKFLISNFGGKITWASGLPIGKYDLTANFSLVIHNVSYSDGGPYVWQLKPKASGLLEAVVNITIVAPPERMEDVTPTSQPDAFQQNIVVIVVAILVVVAMVVVLGVCMYKKRNESSCWERRTHHGDHKAIPMDDVDSVRDTLAEELKEFYKENMENTRIHPLDSSMTRTTEDIYIFPAMFKRSHKTIKAETPTKLKGSQSQYLDDQKGEPVKSLDDLKKLLIKNNHVAVIGSAGCGKTALMEKIGYDWACENFTAFKYVVILRKKEICGTAGVLEAIRKLLPADSDITKQQLGEQIKEHKKKVLMVVDGSFLLESSDMNRPASEGDWSLKDVLSFNALRGCSLLITISSHQLDKLRNLHSRFTVIETTGFSLENIKQYIHQFFEDSDKGDNLIKEVQSSTIFETLAKSPIMLQVLCLIWEHKNSLPRQMANVYDRAVNVLAKHISHDGSDQSDVKKIDGFKTSIGKVAFGGLMDPNEERSDFSEGEFPEESLQFGLRIGVMSKETYTIAEGQTCVVKFLHLYQEYFAACFLVHQGNVREQLLPQVTCDTVRKMGMLIRFCCGMNDRAESLITNHLRGLKDGLKTPDDVAWLQQLIEDPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQU2</accession>
    <name>A0A914AQU2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066132.1">
        <property type="nucleotide sequence ID" value="XM_038210204.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210204.1">
        <property type="protein sequence ID" value="XP_038066132.1"/>
        <property type="gene ID" value="LOC119736179"/>
    </dbReference>
    <dbReference type="GeneID" id="119736179"/>
    <dbReference type="OMA" id="ITDMHCI"/>
    <dbReference type="OrthoDB" id="10006967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000424">
        <property type="entry name" value="Delta and Notch-like epidermal growth factor-related receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="68"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="94"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="91"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="85"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037870995" evidence="8">
        <location>
            <begin position="26"/>
            <end position="4236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="4185"/>
            <end position="4206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="78"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="653"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="694"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="733"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="774"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="815"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="857"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="896"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="937"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1346"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1428"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1513"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1593"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1634"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1675"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1716"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1792"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1832"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1873"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1914"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1955"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2040"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2081"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2120"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2161"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2200"/>
            <end position="2236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2238"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2319"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2358"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2399"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2440"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2481"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2520"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2562"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2600"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2638"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2679"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2720"/>
            <end position="2758"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2760"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2840"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2881"/>
            <end position="2922"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2924"/>
            <end position="2966"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2968"/>
            <end position="3011"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3013"/>
            <end position="3052"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3054"/>
            <end position="3093"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3095"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3222"/>
            <end position="3260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3262"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3345"/>
            <end position="3385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3387"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3470"/>
            <end position="3509"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3511"/>
            <end position="3547"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3548"/>
            <end position="3583"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3585"/>
            <end position="3621"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3623"/>
            <end position="3659"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3661"/>
            <end position="3698"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="3703"/>
            <end position="3816"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3820"/>
            <end position="3856"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3857"/>
            <end position="3894"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3897"/>
            <end position="3933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3935"/>
            <end position="3971"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3972"/>
            <end position="4009"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="4011"/>
            <end position="4047"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="4050"/>
            <end position="4086"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="4088"/>
            <end position="4124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="4126"/>
            <end position="4162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1416"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1542"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1581"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1663"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1685"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1704"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1801"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1820"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1861"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1902"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1943"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1984"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2069"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2108"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2130"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2149"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2188"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2226"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2247"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2266"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2346"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2387"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2428"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2469"/>
            <end position="2478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2508"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2531"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2550"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2588"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2626"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2667"/>
            <end position="2676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2708"/>
            <end position="2717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2729"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2748"/>
            <end position="2757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2789"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2869"/>
            <end position="2878"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2912"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2956"/>
            <end position="2965"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3001"/>
            <end position="3010"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3042"/>
            <end position="3051"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3083"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3124"/>
            <end position="3133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3231"/>
            <end position="3248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3250"/>
            <end position="3259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3375"/>
            <end position="3384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3417"/>
            <end position="3426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3499"/>
            <end position="3508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3537"/>
            <end position="3546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3573"/>
            <end position="3582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3611"/>
            <end position="3620"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3649"/>
            <end position="3658"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3688"/>
            <end position="3697"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3846"/>
            <end position="3855"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3884"/>
            <end position="3893"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3923"/>
            <end position="3932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3961"/>
            <end position="3970"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3999"/>
            <end position="4008"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="4037"/>
            <end position="4046"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="4076"/>
            <end position="4085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="4114"/>
            <end position="4123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="4152"/>
            <end position="4161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="4236" mass="449745" checksum="9811C8CC59868889" modified="2023-02-22" version="1">[encoded data, 4236 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARW0</accession>
    <name>A0A914ARW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066512.1">
        <property type="nucleotide sequence ID" value="XM_038210584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210584.1">
        <property type="protein sequence ID" value="XP_038066512.1"/>
        <property type="gene ID" value="LOC119736569"/>
    </dbReference>
    <dbReference type="GeneID" id="119736569"/>
    <dbReference type="OMA" id="AGIWALN"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="50580" checksum="F672910E51901BA7" modified="2023-02-22" version="1">MGIDMDSVDTATGSEDKPLLEAEKGKQRFPWVSLAIFLVLQILIAVPEGMLQTLSVQFARSAFASERNVTLPVGVNACATSPHDSSELADVQAAVALFATYQSCLKDFIPVLTALPLIALADFTGRRPVLLSICLGGLVEATGFLIVSFFEISVYYTLVGSAVFGVCGGFILLNSISMLYVIDIVPKEHRGVALAMIYAFESAVIYLGPLVINVLLEALSSYTICFLIPACSALLACLWLLPPNLVQESVKKQPLDLGVASGIGRGICRLFTDTFSVRLVVLLACDSVVNLLVEGFDNTVSLYGLGEPFCWSPTLLGVFSVVHGVPHSLAAPLIVWVIELFLSDYWLIYISILSSIAQFLLTAVATSNEVLIYGASLVGIFAGVSQPVFVSLITRLVDTKFHGALFSMYSLVFGASTAFSFILQSAAYSFTVSAGLTVVLFYAMASLSALVLVPTICMHILEPKDGFDDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARZ1</accession>
    <name>A0A914ARZ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066418.1">
        <property type="nucleotide sequence ID" value="XM_038210490.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066424.1">
        <property type="nucleotide sequence ID" value="XM_038210496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210490.1">
        <property type="protein sequence ID" value="XP_038066418.1"/>
        <property type="gene ID" value="LOC119736470"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210496.1">
        <property type="protein sequence ID" value="XP_038066424.1"/>
        <property type="gene ID" value="LOC119736470"/>
    </dbReference>
    <dbReference type="GeneID" id="119736470"/>
    <dbReference type="OMA" id="FRRIQYT"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="133" mass="14735" checksum="95BDCFE17955EAA2" modified="2023-02-22" version="1">MQLFVQGQQIHTLEVTGNESIRDLKLRLESLEGISTADQLLMTGAAILEDDQMLSAYGLSEHATLELSVRMLGGKVHGSLARAGKVKGQTPKVDAEEKKKKKTGRAKRRMLYNRRFVNVVPTFGKRRGPNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASY7</accession>
    <name>A0A914ASY7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066461.1">
        <property type="nucleotide sequence ID" value="XM_038210533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210533.1">
        <property type="protein sequence ID" value="XP_038066461.1"/>
        <property type="gene ID" value="LOC119736521"/>
    </dbReference>
    <dbReference type="GeneID" id="119736521"/>
    <dbReference type="OMA" id="ATTTCNH"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="17039" checksum="16C9E9CD20F85D81" modified="2023-02-22" version="1">MTMHENFFVLHEKQPQQPQQPQQPTTTNNNQQQPPTTTSTNKNHRQPHQPTTTNSNQQQSTTTTTTTDNQRQPKTTTTTTDNQRQPMTTNDNHQQPRQPRQPTTTNNQQPPPTTDNLRQPTTTTTTTTTNNNQQQPTTTNNNQRQPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATW1</accession>
    <name>A0A914ATW1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histamine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067108.1">
        <property type="nucleotide sequence ID" value="XM_038211180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211180.1">
        <property type="protein sequence ID" value="XP_038067108.1"/>
        <property type="gene ID" value="LOC119737088"/>
    </dbReference>
    <dbReference type="GeneID" id="119737088"/>
    <dbReference type="OMA" id="XAIASIG"/>
    <dbReference type="OrthoDB" id="5957730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000118">
        <property type="entry name" value="Histamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37556" checksum="9DB2B5181D5A79F0" modified="2023-02-22" version="1">MYMYVKTVELLRLQDAYGCHAETKSRREENMETKSLPSLFNNQDHYDKAYKVFCARTAKFKTYCDWVDGVFSEAVVGRLQVTLDGEEELRVMGVGSGSGEIDCLMLEQLKKRFPLINNRVVDPSQKLLVQYKAFAQTKAHQLHGVKFDFRQQTIEQYQEAGDGTKFHFISAVHSMYYVDNFDSSVMYLYDLLIPGGALLVILKPESSGWQRFLDRFPHLYGRACCDLQVTSRDLLNLLDRRGIPYTQHHQPTSCDITKCFDEASEEGSLLVDFLTQTVHFKEAAAEDVQRSMMEYLASSDLSERKNDAILLTIGWDAVVIIKQQEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUY6</accession>
    <name>A0A914AUY6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067572.1">
        <property type="nucleotide sequence ID" value="XM_038211644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211644.1">
        <property type="protein sequence ID" value="XP_038067572.1"/>
        <property type="gene ID" value="LOC119737353"/>
    </dbReference>
    <dbReference type="GeneID" id="119737353"/>
    <dbReference type="OMA" id="WDYFFEG"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07595">
        <property type="entry name" value="BAR_RhoGAP_Rich-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000053">
        <property type="entry name" value="SH3 domain-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="251"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="699" mass="76771" checksum="3A97E2DA897A8973" modified="2023-02-22" version="1">MMGKQYNRMKQLAKQNILRAEKTEVLNDDLQQCEKKVDIIKDACQKTVKKLSACLQGSGQDVEKRTRKLPQTVLGQSMLDSSQALGDNSIFGLTLGKTAEIWTSIGQQLTSQEMGLEDLVVSPFSGLLENEIPSVMALKRKLNKLTLDLDSAKGRYQTAASKGTDREHITKVEAIREEMEQCQWKVDACKDSLATEMMSLVSKDSMLARCLVDMVECQAQYHRSVLCRLEKLIPELKDNLSEAPTQGVFGLALEDHLRIQGREIASPLEICICWIMELGMDEEGIFRIAGSASKVKMIRAALDTNVELDMEFGVEHAAAGVLKQYLRELPEPLLTFALYPEFIQTMSIKDKDQKLQALWTVAKKIPKPNYNNFRYLIKFLSNVAKRSEYNKMNASNLSLVVGPNLLWSEEDGGLSMTSTGVSATIIEYFINYADWFFPEEITFAITSSKNNSFSETTQSGVDATDGFPAVSVTPAPADTNSQPSPDVTDTQVQSSPVQHSPAPGPTSPQSETTVAPLTHHLTDKIRSASLPRPKSVKKNPAPPVPSMSPTPSPYSSLPRDTPAPSTSNPGVNNVNGNTPTNSTERVTPERPDRPSKLEKPPVKPDRPVKAEKPAILEKPARPPVPAKKNSQGREIRPTSSPPPISSATDNVPPSPTLRPKSTSLSRPTISPPPPPPPQKSPKRIGSVDSEDIPEEVTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVA0</accession>
    <name>A0A914AVA0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067211.1">
        <property type="nucleotide sequence ID" value="XM_038211283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211283.1">
        <property type="protein sequence ID" value="XP_038067211.1"/>
        <property type="gene ID" value="LOC119737162"/>
    </dbReference>
    <dbReference type="GeneID" id="119737162"/>
    <dbReference type="OMA" id="TELCFES"/>
    <dbReference type="OrthoDB" id="5964095at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="270" mass="30440" checksum="6580278610AB204E" modified="2023-02-22" version="1">MVEGSLRSYDPLAYHVNNLEDIKPEVVRAHRQNNGDEIKRLLAQGDPSDYDVFICVNSGWHAFVLCVPANEVTPKNDPMNVFQDMPTDDPFAIPNQLLVWETELCFESEEQRMYKIRFKLSMFGELKPKIKRSFYIGKYKQVPVSGLQFAILRASPKRYKVLLDDCVEFAKTFCYELLSFSGNGREIEKSVEERLVSASGSGLSVEVLSRRIQSSALLGNTFLGGVDASAFLSAGRRPAVIICLVLFLVLYPIVVPLLVCYMVMSMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWM2</accession>
    <name>A0A914AWM2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068510.1">
        <property type="nucleotide sequence ID" value="XM_038212582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212582.1">
        <property type="protein sequence ID" value="XP_038068510.1"/>
        <property type="gene ID" value="LOC119737921"/>
    </dbReference>
    <dbReference type="GeneID" id="119737921"/>
    <dbReference type="OMA" id="VANKLWV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037126983" evidence="5">
        <location>
            <begin position="25"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="481" mass="53165" checksum="8E73E8932D838710" modified="2023-02-22" version="1">MEWTATILALLSLASIMLCQASQATNPDLIKSMPGLLKQPSFEMYSGYLDGTGANKLHYWYIQSQHAVTDPLIIWLSSGPGCSALYSGLTSNGPFRVQSDGVHLDNNPSSWNLNANLLYIDAPVGTGFSYSANDLYASNDTAVTEDHYQALLSFFTKYPNSTLNNIYLAGDGYSGVYVPLLLAKLDSVSQKLPLQFGGFAVGNPHTSQVLQDNSLIGFAYHHGIIGEQLWAELNISCCSQGKCNFHNNTNKECVSAVNQTVNDVINIGINPFKVNGDCAGGVPVAAGMMGKNGFYHYAPGVQHIFANNDFAQEQQKSIKGIPSWKLKADLTCVDTTPVTTYLNNALVRSALHIVDQSPKWEVCNATVYQLYTQQYPDMSSVYTDLLNTFKYRLLVYSGDQDATHNFLGNEWFVTGLGRQAEVQWRPWLFKNALGQDQVAGFVKEYDNIAYLSIKNAGFWAPQDQPLATSLLIYNFIYKRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWP9</accession>
    <name>A0A914AWP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067686.1">
        <property type="nucleotide sequence ID" value="XM_038211758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWP9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211758.1">
        <property type="protein sequence ID" value="XP_038067686.1"/>
        <property type="gene ID" value="LOC119737420"/>
    </dbReference>
    <dbReference type="GeneID" id="119737420"/>
    <dbReference type="CTD" id="6141"/>
    <dbReference type="OMA" id="RIHEIPA"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="188" mass="21505" checksum="24A8A39809F395C8" modified="2023-02-22" version="1">MGIDLDHSKQRRVRRTEPKSRDIYLGLLVKLYRFLARRTNSKFNKVVLRRLFMSRANRQPLSLARLVRKMKLGGREDKTAVVIGTVTDDLRIFTVPKVKLCALHVTARARARIIKAGGEIITLDQLALKAPKGQNTVLLQGPRKSREVYRHFGKAPGTPHSHTKPYVRAKGRKFERARGKRASRGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX27</accession>
    <name>A0A914AX27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068680.1">
        <property type="nucleotide sequence ID" value="XM_038212752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212752.1">
        <property type="protein sequence ID" value="XP_038068680.1"/>
        <property type="gene ID" value="LOC119738034"/>
    </dbReference>
    <dbReference type="GeneID" id="119738034"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="46"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="488" mass="51870" checksum="38AB42FA2FF0BB0E" modified="2023-02-22" version="1">MMSVGHPHENDVISYTDTVSESVGSLRGLGRANAGRRRGRPRWGRMVVSTSFLTFLLQAGSSMTHGLYMPAFLEEFQAGTGLIGWLTSFSAAVMCLGGPIGGVIVKRLGCRPSVMLGGAMMATGNGLASLCTTIVQLFLCLGLVGLGGSMVSVGLVVAIGQYYTRHHSIANGLAFSGIGAGIFVFSPLVRFLIDNYGWRGSFLVQAGILLNLEVTGALLRPASRYKVRNSRKEKMQSVTESGNNDSNFEEGDESVVLDGSGEHEGTQSSKCTGRSWSLGWLGKFNGLFYLGLCELFRTAPSVVQVYAACFLLDAGVSAVMSHISNLDGVTPQQASSLLPYLGIGSLVGRLIHGGFLKCKHVTPYRMYIAALLVSAPSATLIAITGSFGGRIVEVVIFGFASGSLYPLVAVILRELVGISQLGLAFGLSMFAYGVGGQLGGFIIGVLRDSTGNYTLSFYLVGLFFVIAATVMSLRPLIECRRRRRLTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXP2</accession>
    <name>A0A914AXP2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068910.1">
        <property type="nucleotide sequence ID" value="XM_038212982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212982.1">
        <property type="protein sequence ID" value="XP_038068910.1"/>
        <property type="gene ID" value="LOC119738213"/>
    </dbReference>
    <dbReference type="GeneID" id="119738213"/>
    <dbReference type="OMA" id="CTECFQK"/>
    <dbReference type="OrthoDB" id="10054715at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031601">
        <property type="entry name" value="CCD48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15799">
        <property type="entry name" value="CCD48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="627" mass="68413" checksum="5CFB98FA8C314F47" modified="2023-02-22" version="1">MERPESFIVPARRSQWLVSALAYAFGLDQGIENEVVVLATGIDQYIQEIFHHLDVIGKDRVSLPDFQTLCEVIGFQDCGMSPVAEEPSSPKDPSTELTFKEFHSRLVQCFIGEDTGGGPAGDGVEKRWDNHGKFVEAEVNILPRSGLSVRTMCTECFQKRPVTEIYHSVMFKQGKCCFPGGSSTEVETSNLSGAPFESLGGSVSTYSTDCQCEDHLCGNLPEVRKLQQENDGLREIIEDMRQALQSSDARHLALLVSLRKMQMGSQDGRGQAIPPLPPKLPGHCSIRPQNAVTLSRELSRLRDDRDRQLEEAISYTQSLEADLWQSRRNQDRLDQTRAVLLGQRQSLSQRLCSARETLSSGLERVRKLEKQIERMDKVQARAKELAEWKPCESEGPNPNGESSSRCSEDSGGASEASAISTSGESGGSSEESGTSTEESGASCEESGAPSEDSATSSEDSAGSSEDSGADHLTGMDSGCVSDSERGSPTSAGSEADSSSLGSGSTSDEESAWQEEANNNNNNNTNNNNENCANSALTGGLNDADWLIKLTQVQKHLLETEVEKGQAEGKFKQIRADLLQELNVKLQENEKYQTEIQSLETERVRLSVIESTVGEVIALLRKLRNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY03</accession>
    <name>A0A914AY03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068568.1">
        <property type="nucleotide sequence ID" value="XM_038212640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212640.1">
        <property type="protein sequence ID" value="XP_038068568.1"/>
        <property type="gene ID" value="LOC119737965"/>
    </dbReference>
    <dbReference type="GeneID" id="119737965"/>
    <dbReference type="OMA" id="HDEVNIN"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="228" mass="24855" checksum="6CD8614AFA9A0DCF" modified="2023-02-22" version="1">MGKAEAASKDLDNIWKQKNISYPFSTTAVFVFGVPGNCLILRVYWTKARKTSTHVLIMALAWADLSVCLSMSTMIVKLALECGGNGANSIFFSLIATFADIGVPASLGITALIAADRYDCICRPQKRYCTPRRAKVAVFVVVLFSVMLGFPGGIREYLYPPILSINLLQPIAETIAVLTAFVTIGLCYGKVYAAILKHVKVGGILERTLTQDDQIAIKIDKDRTIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZD9</accession>
    <name>A0A914AZD9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068884.1">
        <property type="nucleotide sequence ID" value="XM_038212956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZD9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212956.1">
        <property type="protein sequence ID" value="XP_038068884.1"/>
        <property type="gene ID" value="LOC119738197"/>
    </dbReference>
    <dbReference type="GeneID" id="119738197"/>
    <dbReference type="OMA" id="VICAKAW"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037137952" evidence="8">
        <location>
            <begin position="28"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="244"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="349"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="420" mass="45237" checksum="211A08D71E388299" modified="2023-02-22" version="1">MSYSASNLLVLAATLITITAPSQLCSAHPVVQDVTSQDQASSSSISGLSCTSSPLGMASGAIPDSSLTASDSYDWRYLPSKARLNGTGWWACPNGKPEGQWIQVDLGQYTAITGVIVQGHRSYYIRTFAVNYSNTGESNDWQKLTDRGQTVQLNGSNGSGQPVNVTFPVVLMARFLRILPLAWAGNYNYYLRFEVLGCRDFKSGMIRLVGGDDKWSGQVEIYRHDAWGAVCDSSWDMKDATTVCHQLGFIEALEAKTGLSSRESDRPIVMNRVACTGTERRLADCPFVCTGSQQCSSSTVAGVVCKPRPDDLRLVGGSRTSGRVEIYRGGSWGTICDSNWNETDAGIVCRQLGFSDALEAKSAAHFGQGSGPVHMDGVACEGSEEKITDCPSYCWEETSCSHSHDAGVICSDGNTVTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZF6</accession>
    <name>A0A914AZF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Perilipin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069053.1">
        <property type="nucleotide sequence ID" value="XM_038213125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213125.1">
        <property type="protein sequence ID" value="XP_038069053.1"/>
        <property type="gene ID" value="LOC119738283"/>
    </dbReference>
    <dbReference type="GeneID" id="119738283"/>
    <dbReference type="OMA" id="MGFISEL"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54395" checksum="134844F32285BD21" modified="2023-02-22" version="1">MVHAFEECPHSEDFVFVLGRTWALSICSEASKQRKALTRVYTETFINISSMKTSGEATKPSMECDMIEPMESGPGNVVVLDSSSGVDIITRVTQIPVVSSTIGQVTNMYTWTKGRSTLANRALGYAEKSVVVAAQTAKPVVDRFEKPISMASEFACHQLDKLEEKVPLISKPTDEVVSTIQDGTRQVIEGTKQKGVEGLNMLMNTRMGKVVSFGLDTALAVSEIAVDYYLPPDDAEKKQEMKDDYDEKETEMEKESPSSVQRVNTLSKKVRRRLHKKALMNIRYAQKRSQETIQKLHFTVDLIDYAKESIDGANQTIRTNAEAAQEKLWNTWNDWTTTEEGKEKETEHSEVTDKEGEQKTLAIARALAGRLRGLTQNIASSVAILPQHIHGKVEEARTMADNIYHSFEEAHYFSDISSSLLTTCREQLNNLSHVSMQVANYVINSSPVQWLTPNEIPNVEMEGIEFDYIPGSDQNDVDLTSDSSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0E9</accession>
    <name>A0A914B0E9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069249.1">
        <property type="nucleotide sequence ID" value="XM_038213321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213321.1">
        <property type="protein sequence ID" value="XP_038069249.1"/>
        <property type="gene ID" value="LOC119738424"/>
    </dbReference>
    <dbReference type="GeneID" id="119738424"/>
    <dbReference type="OMA" id="EDSQWMI"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042984">
        <property type="term" value="P:regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039862">
        <property type="entry name" value="NECAB1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178:SF10">
        <property type="entry name" value="N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="3">
        <location>
            <begin position="227"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="37618" checksum="1B5ED8887654B2A3" modified="2023-02-22" version="1">MASIEKEKGMSIFLDVFRRADKDDDNCLSLEDFRSFFADGVLSAKELDALFHEIDTHNTINIDTGELCTYFSKHLGPYREIFAALEDINVSVSTALQTTATKYPDKTFQDQFCVRFLLKEVQTQLGALLGTISAASDHLEEEAVKNRSGKTQVHFEEPVVSSKAGWLARRARRQLSTQTSVPYDSASMNAFFTQVNRLQGMLDKLETRVTLDPVDEEIVTDDSSMLMLVARKLCVLESEDKAFRSTLRTYVEAAAKNEGCLNLSVRSYSGTSNFTLYEIWDSEESWKNHFASDASKSFRHSNVDHMEKPEQMSNMTIPASWISDSSPTCVISGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0L4</accession>
    <name>A0A914B0L4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069448.1">
        <property type="nucleotide sequence ID" value="XM_038213520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0L4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213520.1">
        <property type="protein sequence ID" value="XP_038069448.1"/>
        <property type="gene ID" value="LOC119738612"/>
    </dbReference>
    <dbReference type="GeneID" id="119738612"/>
    <dbReference type="OMA" id="FESCWST"/>
    <dbReference type="OrthoDB" id="124789at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049218">
        <property type="entry name" value="DUF5575_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20784">
        <property type="entry name" value="DUF5575_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="678" mass="78002" checksum="4E28DF871AC67447" modified="2023-02-22" version="1">MASGSEEEVVHIPSPELGIKFNSYEEVERFIRMHEEANFVKFLKLDSRTVEGSRKRLPKRYLSDELKYATVTFGCIHRGHYKSQSKGLRPRQKTQRMGCQAKFRFSATPDGKQLFLGASVTKHNHPLKEASFRSLPQKRKLNDQEREEACEILQKKGKRSAQKHLQEATGKVLTMKDIHNLAASSRQNLLCYTNIKDILDYLSKLEEQTSVIEVVTNTDGRVVGIYYQDREMMRVYASFPHYLVVDATCRENSLRMPLYIMLVEDSNGEYEIVAYFTVIASNAESIRAMMMRFKEHNPNWPCLQVIMADKDSSTKVLVEQFPGASVQMCLYQVLRKFKQDTSKKQLGLQKEEEAFCEKLMRKLAASKSEAAYMENYKQLLNTELQTMIKYYNTTWHNNRQEWVEGLKSRSVVLKEEDPDKLTAVSEKLKAVLKNSPTSKQVMTNLKREVESLREERDKTAAAIIAENAPKTNPDNTTVSKFQQYLTPFALKYVLRQLKLSWKVIAKANVDSKSMVIKSSKDKMIVSVDSCVCHQWQSLCLPCRHIFAVRRTKGLPLFDKEVIGSRWSLEYYKSCSRLSTQNTDTARSIDALQRQRLRLLSRHEKYIQVSEITQQLATVVSEAPAEQFASQLEAVKKMLTCFQNGSSVNIIEEVGQHTIATEVITESFPFQENNRIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1P8</accession>
    <name>A0A914B1P8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069421.1">
        <property type="nucleotide sequence ID" value="XM_038213493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1P8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213493.1">
        <property type="protein sequence ID" value="XP_038069421.1"/>
        <property type="gene ID" value="LOC119738586"/>
    </dbReference>
    <dbReference type="GeneID" id="119738586"/>
    <dbReference type="OMA" id="CGNPFSC"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF530">
        <property type="entry name" value="MSTPROX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037424843" description="TIR domain-containing protein" evidence="14">
        <location>
            <begin position="20"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="720"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="875" mass="99005" checksum="1E7B71A87DE5919D" modified="2023-02-22" version="1">MKCLAVLVVLLASAHQAASFFNFLSLRQITHDGQSAKFPCKIVNATFVDCRNRGLLNIPSGIPKTTQILLVSHNRISKIDTSLTGLVNLRLLNLSHNSVSKLERGYFADQKQLEHLYLSKNQINKIPEDAFASFTKLKTLDLSWQNNNLRRGFPEFLIPINRTLTTLLLEKTMIKTADFGTHLILRSLKVLNLAANGITSLGRNDFQALAGSQLQVLDLSYNSIENVDTDTLDPFHGVGTLDLTHSFAKLPPLPSLLANVSAAVSSAEIHKLDLRSLSLKNLTSSMFIGLGDSTLEELDLSLNDITGLDDDSFGPNLAHLKVLQLYNNSITTISLNALAGLTALESLYMGSNSLKEIEPGTFKHNTQLLTLNLNDNLIASLSQGGPFQGLINLQRLYLSKNKISQTLTGDEFQDLGDLTDLDLSGSKLLKDRHIRLKMDSFKTLSKLTKLNLKKVWLSNIDIVPSPFAGLLELRFLDLSNNNMDNFHQDTFSSLGRLETLYLDHNHFDNLWHPPNPQEESPSMFLRKLVSLRKLDLSFNGFQNVPIGAFHDLGHLKTLHLSNNKLSEISGKALDGLKELEYLDLHKNLINVVNKTMLTPILKTLKILYICGNPFSCGCEQEWFRDFIDDTQVTIGNLSLCLCASPPGMRNKPLMSFHPEDLNCDHKLPLKDWIGIGVASFSFLLLACILVVYRWKVYYIYLVVRANYRRSKRHNGYEKVFDYDAFISYSGADEEWVAEKLIPELETGEEPFRLCHHGRDFEPGKEIVDNIIESVDSSRRTICVLSQSYLESNWCSFERRVTMSRLFINYQDALILVLLEDLPPKKLSKYDHIHRAIKKKTYLKWPANADERAVFWQRLKDVLNEDRTPDRYEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B221</accession>
    <name>A0A914B221_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069963.1">
        <property type="nucleotide sequence ID" value="XM_038214035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B221"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214035.1">
        <property type="protein sequence ID" value="XP_038069963.1"/>
        <property type="gene ID" value="LOC119739196"/>
    </dbReference>
    <dbReference type="GeneID" id="119739196"/>
    <dbReference type="OMA" id="HDMIATE"/>
    <dbReference type="OrthoDB" id="8872930at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000001">
        <property type="entry name" value="CBFA2/RUNX1 translocation partner 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1110:FF:000001">
        <property type="entry name" value="RUNX1 translocation partner 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1110">
        <property type="entry name" value="TAFH/NHR1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013289">
        <property type="entry name" value="CBFA2T1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014896">
        <property type="entry name" value="NHR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037249">
        <property type="entry name" value="TAFH/NHR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003894">
        <property type="entry name" value="TAFH_NHR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379">
        <property type="entry name" value="MTG8 ETO EIGHT TWENTY ONE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10379:SF14">
        <property type="entry name" value="NERVY, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08788">
        <property type="entry name" value="NHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07531">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01875">
        <property type="entry name" value="ETOFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00549">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158553">
        <property type="entry name" value="TAFH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51119">
        <property type="entry name" value="TAFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAFH" evidence="13">
        <location>
            <begin position="100"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="593" mass="65612" checksum="D657CE8E197F5AD3" modified="2023-02-22" version="1">MYSSPMVLKPRLKEIMKDHSDSRTPESPVEQTTMNKLATQTSPSAVAMATHPRSLSTNSASGSLVNGMHSPHSVNSTPSPPSNVTGMTPAGQELPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRNLVMGLVNNALTVEDFHHKLQEATNFPLRPFVIPFLKANLSLLQRELMHCARLAKMTPSQYYMQHEQQILDGKAVPAEGEAVTDINENGKRRTPDDRIMGRPKENGADHNMTEVPLPKRHCSVSPGSIHLTTPPQAPNHYPAAAMPHHQIRMEDLAHAREMREMARERYERERDRHPGYSFPAREHVYPDQMFLDDRIEDDWKHVDTMLQCIVGMVEKTKRALAVLHQRSIQDREELSLWARRHTESTEQDLKKRADDLIPHGLRGNEERIAEVKRRAGGPRNSLRLGECTFQHLSFEEAVNEVKRQAVSELQKAVAAAEQKANEMVNAERAKLDQAVVDARRQAADNVVSMLNHQEDSSESCWNCGRKANETCSGCNTARYCGSFCQHKDWETHHRVCGQYAAQGTSAQGTRDTTAPQAAGSKPMAAIAASSAAASPAESSHSNVSTAGSPPAAIAVTAEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B355</accession>
    <name>A0A914B355_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 88</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069931.1">
        <property type="nucleotide sequence ID" value="XM_038214003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B355"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214003.1">
        <property type="protein sequence ID" value="XP_038069931.1"/>
        <property type="gene ID" value="LOC119739172"/>
    </dbReference>
    <dbReference type="GeneID" id="119739172"/>
    <dbReference type="CTD" id="126248"/>
    <dbReference type="OMA" id="WDAMDGS"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45048">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45048:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45200" checksum="42B18A616EC63C25" modified="2023-02-22" version="1">MTEVANLDFDPLALEVTNELNNESRSKTGTWEHEDLAQVRYKVLRGHKDGINSCQFCVNDTRILTASDDKTCSLWNVETGDREEKYEGHPSCITQCHMSPDGSKFVSSCWDKRIRVWDVETGEALWTGLQGGIGTCCQFSHNGKLIASGTDLDNCLNIWDVENGQIIQSAKKHHGSSITSCKFSPDDSRVCTTSMDKITKLWDVASKNVTIKLGGHINIVSCCCFNKDERRLCTGSWDKQLQVWDVSTGTYRSEGPVTFSKGHEGSISACKFSSDGSMLISGSYDQTVVVWDAENCGPKLTLKGHTDWVTDVDITQDMKWILSGSRDHTIRLWNIENSDNIPVVLENKKSMGLKIVKCNDCGKPFSISQLDDPQELKMCVFCRLQANRPLLNLSIEEDLNMPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4X7</accession>
    <name>A0A914B4X7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071128.1">
        <property type="nucleotide sequence ID" value="XM_038215200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4X7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215200.1">
        <property type="protein sequence ID" value="XP_038071128.1"/>
        <property type="gene ID" value="LOC119740011"/>
    </dbReference>
    <dbReference type="GeneID" id="119740011"/>
    <dbReference type="OMA" id="RCHARFN"/>
    <dbReference type="OrthoDB" id="10011386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="683" mass="76525" checksum="B6FF1627B525D45E" modified="2023-02-22" version="1">MPKKKVAKLNFTTFLSQLEADDEAVEQYQRALEKINISSTSFRQLSTDEQFGVVVSRFGFLEVCRVQRAIESSDVSSFFDANLFSESLGADSQLCQFLLAVRRPTLSASTSSSTCESPSSSSLQQPSLPSSCSLISSSFSPVDSFDFCLVPPYSTCISCEGNLGHNHVDGTKVKVITLNGCKIGRKSTLRCRHCSLIYRYDSYGNATLGFNLYKEQRQFVRASNTLYLERQLLELQCSLANHSWVSFVGFAESFNDAFGLSRQAGVTSKHISSAFCNGELENELRDLQRLDMFGLMKANSKSDRVKILEQVECIRRQQQYAHPKCHPNCAAKGCGRVFVADGIWKLSFPHCMHKCENKVSGIPVPSLPDVCTKSPVKGKAFCLEHCANAKELKIPTDLHAFLKHCDVKQPDPVSKGPSTSTGSQGSDKIADKLCLAPGASCNAQTIAKVEEVLSKLQPVPSTGESVVDAQGTKSFLSQHSASMSTMMKDCVEEVPSTCKKDVGARKRLQKWSRGHLFVVRAGGHIEFWQTLYKSESPSQVFLILVSWLSEYLKTVPVNSWSNVAVVYDNMCHLDNMKVARKPLPLDWPWSQMWLSLHKCVDRLHIRNHTDKLCKTKYHPSDHLAETDNTLSAEQTFVWLSRFKKILCAMPKVKHMFYLHRMVVRRNRYTAYCYNSGTTQCFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B570</accession>
    <name>A0A914B570_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071228.1">
        <property type="nucleotide sequence ID" value="XM_038215300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B570"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215300.1">
        <property type="protein sequence ID" value="XP_038071228.1"/>
        <property type="gene ID" value="LOC119740098"/>
    </dbReference>
    <dbReference type="GeneID" id="119740098"/>
    <dbReference type="OMA" id="RECKPRE"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="712"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111947" checksum="AF3F78874519E513" modified="2023-02-22" version="1">MQDFEGEKRNFEGEMQDFEGEMRDFEGEMRDFEDEPHYKKWISFSLLCISAVMIALAGILIFNFYEIPAASHVQSGETVPTPKVLSDLEYCQQQLKQFYKDTTSTIPSRPLLPSRTVKIDEFFVNLELSREVAGKIMPGDRVKLSGEQMVFDKVPAVPLDTWEDLFKPEIVEESKIILAVVSEYAQLSYTRRGDINLGGLIPVHFGDCEATPTMWSLQLIEAMVFAIEEINNRSDLLPTISIGFDIRDSCFDEDVGLLSALSLVDRGASLIDQPDESSLCKNNSQDLSKKVVGIVGPLKSSVSIVVGSVADLQKLPMIAFAATSDELSDKERFPYFLRTVPPDRLQATAMVDIITHMGWEYISIIYLADTYGIRGAHALARLAGSRGVCVAHLLPIQQVPSRSELEEISALLWESYKARVLVVFAGPEPATELVNAVENTSNVNDHFIWLGSESWVHSLSRLNKIPPKGALFLSLHNPEPDGFFEYISNLNRDTIQKNPWFESFLSNWEVLHNCTIWFDRQCGLPHLAQYTVTSPMAPVIDAVYAFAHALHSLIYSSNSSTVNGTKLLDALKEVRFDGQRGRFQFNSAGDMEGKYLVQNAQFDSDGFRLVNVGLWDALSMSDDYLTISGDIVWMNGLTEIPTSTCKDVCLPGQRLVPLEEKCCFGCFPCEPYAIVVNNGTECKECEETEWPDKLRLSCLQIIPAFTDWTDPLHLSITILSCMGLAVSMMIAAGLVIYRNHSVIKATSRELSCVNVLGFNLAFVSTFLLIAQPTTIICCVSQAMVSLCFTLAYAPTLLKVGRIYRIFRAGKRSARRPGLISPGVQLIMVFVLVMIQVFCVILSAALGPCEPQYLIPIPRDGHLELYCQLGTGFLISSSYNLVLILACCVFAFLARKVPDNYNESKFIGVSVYSTLLACLAAIAVYYTARDVSQKVAAICLAVLLNAFLTVGCVYIPKLYAIRFINPPSSTVFTIGRAHTSTIESIDNRVGPMSGNWATKTSKIQGDTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6T4</accession>
    <name>A0A914B6T4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038071916.1">
        <property type="nucleotide sequence ID" value="XM_038215988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6T4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215988.1">
        <property type="protein sequence ID" value="XP_038071916.1"/>
        <property type="gene ID" value="LOC119740624"/>
    </dbReference>
    <dbReference type="GeneID" id="119740624"/>
    <dbReference type="OMA" id="KFRWNVF"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="64"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="548" mass="61823" checksum="0A59165750482EBE" modified="2023-02-22" version="1">MSFCIVSLARIGRQASRGVASSAKGANFWSRRNLSSSSIMANRDKASNQMEDYKKTVDKMERLTTSTGMPIDNKLATMTVGERGPVLMQDFVFSDEMSHFGRERIPERVVHAKGAGAFGYFEVTHDISKYTKACVFESIGKKTPVAVRFSTVGGESGSADTARDPRGFAIKFYSEDGNWDLVGNNTPIFFIRDPIFFPSFIHTQKRNPVTHLKDPDMFWDFITLRPEATHQVSFLFSDRGTPDGYRHMNGYGSHTFKMVNKDGQGVYCKFHFKTDQGIRNLNAAQADALASSDPDYAIRDLHNAIATNNFPSWSVKLQVMTFEQAEKHRDNPFDLTKVWSQKEYPLIPVGKMVLNLNPRNYFAEVEQIAFAPAHMIPGIEASPDKMLQGRLFSYPDTHRHRLGTNYLQIPVNCPYKAKTRNYQRDGPQCVTDNQTGAPNYFPNSFNGPQDDLKYAQQTFHCSGDVARYNTKDDDNFTQPGHLWNNVLTPADQDALVSNMAGHLKNAQEFIQKRAVENWSQCDKEWGRRLQAALDEHKANAAKAAVAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6Y6</accession>
    <name>A0A914B6Y6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071580.1">
        <property type="nucleotide sequence ID" value="XM_038215652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6Y6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215652.1">
        <property type="protein sequence ID" value="XP_038071580.1"/>
        <property type="gene ID" value="LOC119740377"/>
    </dbReference>
    <dbReference type="GeneID" id="119740377"/>
    <dbReference type="OMA" id="MYAHVVN"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="67132" checksum="215868E13B7634E9" modified="2023-02-22" version="1">MPNKTKKEKAATKPAGGNNKTSSKDGIDGPDETRHRTTNVPPPTQLTRSKGTGPLVKKEKRQGSSRFNISKNRELQRLPLLKDATPAEREDLFMQKLQQCSVVFDFISDPLSDLKWKEVKRAALNELVDFVTHQRGVITEPIYPEAVKMFSINMFRTLPPPSNPSGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESADFQPNVAKKHIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKHINHIFYRFVYETEHHNGVAELLEILGSIINGFALPLKEEHKSFLLRVLMPLHKAKSLSVYHPQLAYCVVQFLEKDPTLTEKVLKLLLKYWPKVHSPKEVMFLNELEEILDVIEPAEFNKVIEPLFQQLSKCVSSPHFQVAERALYYWNNEYIMSLISDNAATILPIMFPALYKNSKAHWNKTIHGLIYNALKLFMEMNQKLFDECSQKYKQERQSEKDRLKRRDEQWNRLEGVAKQNPMFERLHNDIHEENSRMEVDTDEDVYDGDITKDVATEAKAPTGVKKEPVKQLIRRKSELPHDAYTMRALTTHKRPDEYLVSSQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7U4</accession>
    <name>A0A914B7U4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072049.1">
        <property type="nucleotide sequence ID" value="XM_038216121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072050.1">
        <property type="nucleotide sequence ID" value="XM_038216122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7U4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216121.1">
        <property type="protein sequence ID" value="XP_038072049.1"/>
        <property type="gene ID" value="LOC119740728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216122.1">
        <property type="protein sequence ID" value="XP_038072050.1"/>
        <property type="gene ID" value="LOC119740728"/>
    </dbReference>
    <dbReference type="GeneID" id="119740728"/>
    <dbReference type="OMA" id="VANHVAW"/>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="390" mass="44714" checksum="1487CF3773AFE0B5" modified="2023-02-22" version="1">MTTPSTLPLLPPLTPMGVCKGAVCITAMALTATVGSVFMMGPILPLMVIRPRLFRWVTDWMMNLWLLLPVALMELFMGVTIMTSGDTLQSDEGSIILMNHRTRLDWFFFWAVLHRQSTLRTEKIILKNDPKVVPGFGWAMQVACYIFLKRRWETDKPWLLSMLEYFGLLQYKGQFLIFPEGTNFDGKGKASSDRFAQKNSLPEYKYCMHPRTTGLVFLTQELRQKNLLDTVYDVTVTYPDSIPEHGELDLVLGNLPSRVNFHIRRLPQASLPASKEGLEAWCLERWQAKEAALGAFYTGSKDYLVFPGGEGDGSEMHTQGSDRGTLYIVLLYWIAFLVAAFTLLWYSIIARWYFLLITAFFIYQLVVRGGVETSIIKSCRWFYVQKDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8V1</accession>
    <name>A0A914B8V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072260.1">
        <property type="nucleotide sequence ID" value="XM_038216332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216332.1">
        <property type="protein sequence ID" value="XP_038072260.1"/>
        <property type="gene ID" value="LOC119740874"/>
    </dbReference>
    <dbReference type="GeneID" id="119740874"/>
    <dbReference type="OMA" id="DKHGNFM"/>
    <dbReference type="OrthoDB" id="10071811at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039302">
        <property type="entry name" value="MAP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="848"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113252" checksum="363F254E6408347B" modified="2023-02-22" version="1">MGSNETLFSLELAVESLRINSSTVVCHLPSVAFRLLDFPTLLLHHVDPEEAQNIKEKIILDSFGDIPCQLQELKDHRGNFCINKCKSSLFKMDPQMLLSYLRNTPLYVMLIDVWPKVPKLVANCTVSLQTTMEEISHDIEQNGSDVPSVHGDRDSYKLYNLMGSEVGWIVVRYRMLSMGASLIPHIPQSEITKRGSETVDLALAVTPRKSKDDGVVRDTKKGNKETDVVLEDLEVQGQPKGISVAVSTIDDRDFIPKPAGSEKKQQATQTIKTTKGSGHRKNVFQRSTQLIRNDDLIVNNTHCPPPLFFNTANEDVPASSDQHRHVESVRRIDQDIQYFLSGRNAEPKTRAESFSEDLSSSSQTQSDDIVHQIETHYKFPSEEQSTASPSWSVRKTHRALRKEKSHAKRMERQPEERKTKSETESAQEAGYQASDICNRCQLKLEPNQRSQLPVLEALLQELSLLHGNSLHNRAATLSRTPAQVHVQHAVAKNQVTIKEPTDEKENVHVNQPKVVHQTKPYRHKHRECAKPPQGVPPTKGWLRQQKPVPKVKRRTKLRFGMTNSQKLRLQKNNPELLREMEIQEARMRAYQEEKEKAIKNHHVTDELDFIDAVNEHDISTEIAHHFEGEDQAVHARHPQKKLPSRADSGKSSASQTKAAQQKRRKEHSDQRNRQIVSPEQPPVAAPRRPKGATYSWADKSSPHSEDGMGTDQEAADDGIGASGTEASDFRFDGSRRDSRGSVVQKDLSSSEKSARSIDVYLPSASVPESDSGSNSDDSTDTDLQFSSASSYVKHPKAIQIPGLPSEQDLPQEAVNQSDDPTDIQYSDDFVGSDNLASTGEQELAPLASNHSDSYHSTHSSVSGTSRSSSVRTTKSQTTQIAGKTPEASGPRPSGKPANPQTRRLSIPKPKLSSISPVPVRKTSKTSTLSINTAVVTPDPPSETKRSQTPPTPKPRPSLLRSASSFSETSLLQSTVPSSEFKTEDSLNPGQWTKQDESSNSYSDDFNNSEPISDHSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9A9</accession>
    <name>A0A914B9A9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072420.1">
        <property type="nucleotide sequence ID" value="XM_038216492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9A9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216492.1">
        <property type="protein sequence ID" value="XP_038072420.1"/>
        <property type="gene ID" value="LOC119740966"/>
    </dbReference>
    <dbReference type="GeneID" id="119740966"/>
    <dbReference type="CTD" id="284485"/>
    <dbReference type="OMA" id="EGMEPYD"/>
    <dbReference type="OrthoDB" id="10249338at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22971">
        <property type="entry name" value="DD_RIIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059162">
        <property type="entry name" value="RIIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF4">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="12090" checksum="7749886AEF583C3D" modified="2023-02-22" version="1">MAVPNHNPPRGMEGYDLGALSAEQQEKLNQFKIQTRLGNEKFLRDHPEVDVLLAGFLGDVLTQRPENIRDFAADYFTKPHLKDSVQSQLKQRENALREAKFNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA57</accession>
    <name>A0A914BA57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072884.1">
        <property type="nucleotide sequence ID" value="XM_038216956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216956.1">
        <property type="protein sequence ID" value="XP_038072884.1"/>
        <property type="gene ID" value="LOC119741220"/>
    </dbReference>
    <dbReference type="GeneID" id="119741220"/>
    <dbReference type="CTD" id="81556"/>
    <dbReference type="OMA" id="QSSVVWI"/>
    <dbReference type="OrthoDB" id="2374335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="7">
        <location>
            <begin position="214"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="8">
        <location>
            <begin position="416"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="521" mass="57098" checksum="B1E7CFF8883754BD" modified="2023-02-22" version="1">MPTVILLDVSLSMTRPVAPAEGSSGGDVITRRQLAEAGLSALFDFVAANDKLEFTALVIFSSLWEVVVPFTRDFAELKKALLSVETFDKTNLEVALEGVRNMVVEEWGVSSPCQIILVTDGSPGIGPGSLKQVAQMLSDPKPDDPPFPLPFEFSNNLHMVLLSTPAELQQWNSQALCQRLLDANRQNGKVHSVEGALTVKSAQQMFTALAEEHYSAFHAKLVCGHLSSDVQLFPPPQKLNIMRDFEVVSQTVSSELSICGFLDCSDVCSPPVISRHLMLPLPNKEKSSVTSGEGGAEGGDKTEEKDNGPTPSEVGSTPSFCVLLHGSLKVENLVALVNVGENWYGLLHSCADSKKKSNLMMSLFEHGDKAIPWLGRFHLLGPCSAAFASDPYGEDSNKTPFPVRLQDKRSYSQNPVVWIRPNSLQTDIQKILRYARKLPEKTQVFYKELNRLRRAALSLGMTELLSGMSQMLERECTILPWTAHPDAAMQLTHAAKMMTSAVEKGYSYSIIPLSTNFATDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA76</accession>
    <name>A0A914BA76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072904.1">
        <property type="nucleotide sequence ID" value="XM_038216976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216976.1">
        <property type="protein sequence ID" value="XP_038072904.1"/>
        <property type="gene ID" value="LOC119741233"/>
    </dbReference>
    <dbReference type="GeneID" id="119741233"/>
    <dbReference type="OMA" id="QAKLCAY"/>
    <dbReference type="OrthoDB" id="9899341at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052835">
        <property type="entry name" value="Nepro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761:SF1">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="731" mass="83318" checksum="DB12D2740ACDC412" modified="2023-02-22" version="1">MKDKMAASMWNDTRVSPPPIASCSYDCYEIEEVDVYNLKLALQVIQTSHTTGLGLSSEQYTLSRLLYKANNQQRHWRWYQMLKKIQKGLRRLQANNPVKFMEDAIGCCQINRNQTGCGSITIHLPACQMLEYILVKLMVQAKLCAYILNMAEKVYVFVVQNITSGQFLAHNTIYASIVSRIWVMMRAMLRDILPWYSTLRPWADRLKATSMQWMSAGEVLPQSLYDWLRPDYDPYKYANAIDQTSKKTSSSLLDNMFPAANLATPEAAISASSIDRDLHGKDVAMAPSLAPSMDLGEPITARELSENRKRKQTDSDYLQEPATKKSRCEIESWTPEDPTMRIASGTTIVQPETCMKESRFSHEIEHSEDVDLGQMKNKKQSKGILRHLKQRLKGEEKRTELASDSESRTNKVAGSSNREPEGRRTTWRKNLKKSLKKTFEKLTKNPSANNDKTNPDLELSMDELNPVGEEQRSAASVGWSEVGHGRKKLKGTRKVTKEALATDSKDSACKGQVEGMHKDQMDKAEGFQSRLKLPKKSKERQEIEDRQHEAKDPIVSSVAHDMENPFTLTFCPPETSQSKTSKKLKKKAKDKKKSKKLSSSSEDRHPQICEEMSNRISNITEEFVKHNKRKQHNDERESKNRNSQEKPVEKFLPTSPSQAPHQDQIKTKKKAVKRKREVTESGVSLKGIFKKSKKHQSESSLVCDLGQITRREPVKSNNQESDIDNIFALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB67</accession>
    <name>A0A914BB67_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073085.1">
        <property type="nucleotide sequence ID" value="XM_038217157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB67"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217157.1">
        <property type="protein sequence ID" value="XP_038073085.1"/>
        <property type="gene ID" value="LOC119741414"/>
    </dbReference>
    <dbReference type="GeneID" id="119741414"/>
    <dbReference type="OMA" id="MSHEMEF"/>
    <dbReference type="OrthoDB" id="6060011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.75.10:FF:000001">
        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF30">
        <property type="entry name" value="ELAFIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037700517" description="WAP domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="37570" checksum="038CB66FCE8A6093" modified="2023-02-22" version="1">MELKIPFCLIFMLTGGAAEWKPGQCPISDGGQLGICVQECAVDFDCYGNQKCCKNGCGMTCRYPENIGVPHAGLCPAVNSSEPAMCIDPPPCDIDQDCVSHEKCCFTGCSFMCVASERREENRLGMCPAEVPSILRQTRQDPVKTNCTVRCADDRDCDVDRKCCNDAVCGRTCTEPVYACYHNGRIYQNHENIVESDGCSSCSCLDGFLACKQIYCGKITSVAIQQPLCVHVHKIPEAHQNEDCKLIQQTIQQSNMCSIVQSLCSWLSFSILIIDPALDKIRILTICLIALGGVCLVGSILSFLKYQHSKRSCSIRNKGKNQAVNMMSHEMEFLDPIPTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBB9</accession>
    <name>A0A914BBB9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073513.1">
        <property type="nucleotide sequence ID" value="XM_038217585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217585.1">
        <property type="protein sequence ID" value="XP_038073513.1"/>
        <property type="gene ID" value="LOC119741717"/>
    </dbReference>
    <dbReference type="GeneID" id="119741717"/>
    <dbReference type="OMA" id="DNHIAFH"/>
    <dbReference type="OrthoDB" id="5963802at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="51030" checksum="523CB3237AAC27D5" modified="2023-02-22" version="1">MDSKPLVNSMEETPVSTALPSAPATQNMQNTGGLQPGSQASSGRSSPYQAQTQHSVQPENPSSVQGFQYKQQPPASVVQNQAMQQQQLQQQQQQALLQQQVMQQQRGMQQQQFMRQQQQQQQQQQQQQQGTQQPQGMQHLQGTPQQQQYRPMQRQQHQQPVQQYQMQQQQALRPQPMVQPPPPPPPPSQAELARFNFDPESNAVLQSLGGRHANSVHQVTGYVNGALKEVMATAGNLELPTNCQMEYDTLLDSILLSDETASDNYIAFYKVAFQRINDTKSGVEAPAKANMTPGRAYLTNKRLIFLSAEETKGLNLTSEGQAKISAYSVRGHKAYSLRYESIPLTCFRGVDISSVHGFSATARIQGFFPDSLGRCLQPCCSDEQYRERWQPQRPLTASIDNRVINLGAFLPPWETKCNIQVYMSKDTELPAAVEFVSALQQTTPGLQPESFSIPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBY8</accession>
    <name>A0A914BBY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072947.1">
        <property type="nucleotide sequence ID" value="XM_038217019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217019.1">
        <property type="protein sequence ID" value="XP_038072947.1"/>
        <property type="gene ID" value="LOC119741267"/>
    </dbReference>
    <dbReference type="GeneID" id="119741267"/>
    <dbReference type="OMA" id="YLMSENF"/>
    <dbReference type="OrthoDB" id="6272653at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41422" checksum="CCF60408D47DEADB" modified="2023-02-22" version="1">MAPMNKSSDFGMEMFDQSKQSNKNAVFWRWFVAGTLLNLCITSVLVGLTVFYVHTELKSVRQQIASNEDRLSLVEKAMPQGTPDPTSTNAQLRIRRDQGNPLPVSHTVNQNVTFPFAWDIGRFGYGGCRDGRDGRDGRDGIQGPAGQQGPKGVKGEPGLPGAAGKAGPRGLKGDSEDTEPRDHRDNRMLLGGETYVRWGRTICPNHTSTELVYAGFATGSHYTQKGGSVDFICLPTNPDWAASYNDGFNSHSYLYGTEYEVSNYDPFSHENAEVLHDHDVPCAVCRLVDRGTQHLFPAKLGCPETWTEEYRGFLMSGYHSHEQRSKAVCVDQAPEVVSGSHASQDGALLYIIEGVCVPLHCPPYVNGREITCTVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BE13</accession>
    <name>A0A914BE13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038074100.1">
        <property type="nucleotide sequence ID" value="XM_038218172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BE13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218172.1">
        <property type="protein sequence ID" value="XP_038074100.1"/>
        <property type="gene ID" value="LOC119742140"/>
    </dbReference>
    <dbReference type="GeneID" id="119742140"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000027">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="293" mass="31865" checksum="B40FFE66241FE320" modified="2023-02-22" version="1">MVFRTPRMINCGTTPAAGRFYFAAVTFSVLYSIISMGAPFSRSVMAWRSSGSTHEELVYKLKQHGIIKSESVHDALKQVDRKHYSKSKTDPYADSPQGIGYAVTISAPHMHAHALELLKDHLTEGKTALDVGSGSGYLTACMGIMVGETGHVVGIDHIKELVDWSIANVQKEHAYLLESGRVKLITGDGRRGYLEGAPYDAIHVGAAAPVLPPALIEQLKPGGRLIIPVGPQGANQMLEQYDKDMEGRVTKKNLMGVVYVPLTSKEQQWPGRLLEAILKRQKSGESKEAGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEG6</accession>
    <name>A0A914BEG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074361.1">
        <property type="nucleotide sequence ID" value="XM_038218433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218433.1">
        <property type="protein sequence ID" value="XP_038074361.1"/>
        <property type="gene ID" value="LOC119742493"/>
    </dbReference>
    <dbReference type="GeneID" id="119742493"/>
    <dbReference type="CTD" id="9342"/>
    <dbReference type="OMA" id="NLDEMCD"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15856">
        <property type="entry name" value="SNARE_SNAP29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15887">
        <property type="entry name" value="SNARE_SNAP29N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000041">
        <property type="entry name" value="Synaptosomal-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="281" mass="32069" checksum="3BF8B1A3D15C18EA" modified="2023-02-22" version="1">MSNVRRPKNPFDDDDDEPNDFVFVPRGPSRPQEKKYPYGDFGIDEDDQEKDDHDGAVSLQTQIEERQQNMLQSTNRSLGMMYEAENVGNETAHELLRQGEQLQNIDKKLDKMNTDIDTSKKHVTSLRSVFGGVVNYFSKKPEREKPEEQERAPSKLRTMVGDGPGAKKEEQDCMDHPAMRLRDPNAGRYNSRYDTSGFEETPSSSMRGTGYNSSRQQFEQKLDSNLDEMSSGLGRLKNLGLGLGDEIERQNDDIDRITGKTDKLDTRIEGVNTDIKKILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF16</accession>
    <name>A0A914BF16_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074838.1">
        <property type="nucleotide sequence ID" value="XM_038218910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218910.1">
        <property type="protein sequence ID" value="XP_038074838.1"/>
        <property type="gene ID" value="LOC119742738"/>
    </dbReference>
    <dbReference type="GeneID" id="119742738"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="113" mass="12756" checksum="7692B2CFE744A8C1" modified="2023-02-22" version="1">MVDWMTLVCLYRCTLTGGPGRQDDCVKRPMVTMDLLRAGKTTAQPPSNPLNSNIKENTPNNNTRNSQPGAFGLDIPQLMPDTVLKAKDVIYFLKDEARERERERERDQSGTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFA8</accession>
    <name>A0A914BFA8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074614.1">
        <property type="nucleotide sequence ID" value="XM_038218686.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074616.1">
        <property type="nucleotide sequence ID" value="XM_038218688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218686.1">
        <property type="protein sequence ID" value="XP_038074614.1"/>
        <property type="gene ID" value="LOC119742589"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218688.1">
        <property type="protein sequence ID" value="XP_038074616.1"/>
        <property type="gene ID" value="LOC119742589"/>
    </dbReference>
    <dbReference type="GeneID" id="119742589"/>
    <dbReference type="OMA" id="SCYWQLP"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF30">
        <property type="entry name" value="ELAFIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275770" description="WAP domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="252"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="476"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="539"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="594"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="643"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="691"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="740"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="788"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="865"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="927"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="971"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1176" mass="122355" checksum="868D674958D4E367" modified="2023-02-22" version="1">MKTLVILCMLAAVGVGVVHGGEALCHSDVGDTINEGCVNCTCVLESPSNPVTKVWSCVQTCNVCPAAVVSRICLFNRCDSGVYCPLDRLNTTCVIPLCETCDPAFLRDGNLVNCTDKPGMCPEPVGTGNCTQQCSEDLNCPNNQKCCSNGCGTACYEPVHDRKEGMCPMPGPDVGGICVNTCHGDRDCPGTQKCCSNGCGHTCQEPAASMKPGMCPMPGPDVGGVCVEMCSGDGECPGAEKCCSNGCGHSCQAPAPRMCPAPGPDVGGICAEMCSGDSDCEGMQMCCSNGCGHSCQEPVPEMHPCPPDQPFMNCTYDDVCSSPCDALPSARCLVDHCGGCRPVHITSIGSRINCTTGQVVQCPPGHEMVNCLLNPCDSAECPADPMARCLSVYCGGCKAVFVNAQGEHINCTSGAASVCPPGLVENPVDRAQACAMATCPARPKAQCTAKQCVWPNSPLECPYEFFDARARPVQCSIVKRGQCPMVDSSGDVGGICVNECMDDTHCDGDEKCCGNECGGRVCRDPENDGSEMDMDMEEPIWKPGTCPMPPMGSVGGICVEECNAEYGDAGCPRHWKCCSNGCGHACRPPREMSGQCPMVPEGADMSDCQDLEECTLDNECQMNRPGSKCCTTACGTRCMSPVRSRKPGTCPMVPMDVAGICSEDCTSDDDCEARAKCCSNGCGHVCMDPEEQPGDCPARPDLMMLYAAPQVACSSDSDCSQRRSKCCAYGCGQICIEPVTDVKEGMCPMPGPVVGGVCVEMCSEDGECPGTRKCCSNGCGHSCQEAVPRMKPGMCPMPGPDVGGICAEMCSGDGACPGAEKCCSNGCGHSCQAPAPGMCPMPGPDVGGICAEMCSGDGDCEGMQMCCSNGCGHSCQEPVPVPQHMCPMAGPDIGGICVETCSGDGDCPGMQMCCSNGCGHSCQVPVPYVKPGMCPMPGPDVGGICAEMCSGDGACPGAEKCCSNGCGHSCQAPAPGMCPVPAPDVGGICAETCSGDRDCPGMQMCCSNGCGHSCQEPVPLEKVGVCPMVPPGLESNCMQKSCTGDHNCPGRKRCCEAGCEEHMCLVPRPEVMCEEELPEICEFDPCEFATCPSVPDATCAPDKCGRCRPRFFNQDLEAVSCAGKTFCKALGGADGWYESGAIVDSSDGCNQCVCNGLGTWTCSKRNCGKWLLFTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFI9</accession>
    <name>A0A914BFI9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="45 46">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074207.1">
        <property type="nucleotide sequence ID" value="XM_038218279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFI9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218279.1">
        <property type="protein sequence ID" value="XP_038074207.1"/>
        <property type="gene ID" value="LOC119742381"/>
    </dbReference>
    <dbReference type="GeneID" id="119742381"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050253">
        <property type="term" value="F:retinyl-palmitate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 44" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="44">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696375" description="Phospholipase B1, membrane-associated" evidence="44">
        <location>
            <begin position="23"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="43">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="464" mass="50641" checksum="8BBA2744E842A6D1" modified="2023-02-22" version="1">MSLSKDLGRLSFLLSALIFLLAVEVDVFGIAQDFEYDYDGVIADDYSDWNRTIRDLITLLPGYNCTGDPTWPYGVEQIFPCQILPPSESPPNSVHMLRPADINVIGAIGDSLTAANGGGACSLPQLLFQYRGKSFSHGGDESYETVPTLANILRKYNPNLKGYGVGTGTWSTDNAGMNVAVPGSVAYEIQEQAERLVQKMKDDASIDYEKDWKLVTIFIGGNDLCEVCKDKTLYSPGAYVNNVQRAIQVLHNKMPRTFVNVIGILDLRQINEFRGFVCKASHIGFCPCVAAVRDDELEKEWTPTLLQYQSQLEALVTSGTFDDKEDFTVVYQPFLHESKIPMIGGAGDLSYMAPDCFHFSAKGHAETGKSLWNNMVQPVGSKATAWVLDGPFTCPTKESPFLYTNVNSRKGASSTKRPVTEKKGGAVTADTADDGPGGDASVFSPAHQLALLVIGAFVSMFNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH05</accession>
    <name>A0A914BH05_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075547.1">
        <property type="nucleotide sequence ID" value="XM_038219619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075548.1">
        <property type="nucleotide sequence ID" value="XM_038219620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219619.1">
        <property type="protein sequence ID" value="XP_038075547.1"/>
        <property type="gene ID" value="LOC119743229"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219620.1">
        <property type="protein sequence ID" value="XP_038075548.1"/>
        <property type="gene ID" value="LOC119743229"/>
    </dbReference>
    <dbReference type="GeneID" id="119743229"/>
    <dbReference type="OMA" id="MELWTEN"/>
    <dbReference type="OrthoDB" id="542946at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1208" mass="136050" checksum="ECD7AFEFCA61DB92" modified="2023-02-22" version="1">MASQHQSRRSVRGGPPAAPSRQWSTVGQPTGKANYRPMTGMSRRPSRQQLQKPARQDSIPEAERNESTPDQNEQPVQPLPNSKKRYSYGQPSDPRVAAEMAVLTEYVKEKSLMSTMMTCCQAVLQRESLPYNPYPVFVSWMRREAERFHMFAKSTKSIQATLTSKQQSTTTPHIYGVKGHSNAWGLEAVINAVDPQALKRYDWLVEDETPTKLVLSDEQQEYSGQILVAMVGPAAFTGTMYRKAPSIDIRVEYVIYGPDLPTALLIFNSCISEDIRRHISADCPHRILGIVVPRSQPNENELWTVEQAREKWDDFWDTVRDSVLQKRPIVLQCMFLLDEETAEYRIGNKQFILHFVETSENSQQERFRSFAELPYLTLYEGIFLRKAHAETYVMTLKRLQETTNQSGANANGHRESMEDSLASLHEAERDDGSDLVNADEVREPIRAKWQRQIAKCHPVRDALILAHLTFLLALSDRSVQGSEVRIELYRFLHSTAASWYAATVLNSALQVLVTTIDQENEDDGKFLTQQFLEYKTKLLTAINPELHARSSEMYILHRNLGNVLQNMLIPDPSDASKVVLKALDLNTLQQIQNACLSLQLLLTEDAMFFFKRLNFKTLVRGCREAFNMNAAKAADAGKKKPQVKSTKSSNSLTAQTSSPAKMNHGVEVKEITQQKNIVIDVEEVKSFSNWPRIMVTEAVLMQYMVDIKLDQVWHEYLLELLTGDHLPPNPYPRLVTVLRQAAHRMQLCAETNASLSTKLLRPDQTKLVDRINSIHGVTSVGAYGLSPRTLAGLDAEPSGFIKIAKLMEGLTNKEVVARRGQFQIEVSLAVGRGCAFYGRLVPYLITLHLYEHYYIRGNIGADSDAIQLYAKLLYDNISSLSAQNHHILLGVFFGGGSRYMSEADLVDDKATFFSHVVDAARKKEDIHLKIYQPIGWRYLRIHKHFVLHYLFVDNTEDRHECYSPDDPSSVCQSVFLSQAQASAHARGGGAKQLGNLESATNLRGVNEYLSKEIEGALDGHQVMPAYQHILCKALVNKDKKLIADAWRALHSLAYQLDYIQAINQDLQDLVRYALLFPGKLIKASASSQSLAKGRGNKAKGEAGPSSQGPFNDAALAKFASVYSEKLTSVLQEPCAFVPSSLLQVIQDKLQTIVDVDNQTNRQSLPIEQETISTLKEIWQLIHPVQDWTSFDVHKALSHHGNGFISPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI84</accession>
    <name>A0A914BI84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="RefSeq" id="XP_038075804.1">
        <property type="nucleotide sequence ID" value="XM_038219876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219876.1">
        <property type="protein sequence ID" value="XP_038075804.1"/>
        <property type="gene ID" value="LOC119743465"/>
    </dbReference>
    <dbReference type="GeneID" id="119743465"/>
    <dbReference type="OMA" id="VECHWPY"/>
    <dbReference type="OrthoDB" id="4214675at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000007">
        <property type="entry name" value="Hydroxypyruvate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="269" mass="30411" checksum="51E9831E62C60E63" modified="2023-02-22" version="1">MPLKFAANLSMLFKEIPDLAERYSAAKRAGFQAVEVSFPYECPVEKLVEVKEKEGLQQVLINSFPGDVKAGDLGLAAVPGREKEFQETLELSIKYCTALKCKRMHVMAGVTPDCTEGERPALLRKMEETFLSNLKYAAERLNKDGILALIEPINTVVSRPGYFLSRQDQGVEIIKKVGHPNLKLQMDLFHVQMMQGNITNTIKEFFPYIGHMQMAQVPHRNEPSADGEVNYGFILSYLESLGYDGWMGAEYIPAHGKTEDTLKWLEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIT1</accession>
    <name>A0A914BIT1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075810.1">
        <property type="nucleotide sequence ID" value="XM_038219882.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075811.1">
        <property type="nucleotide sequence ID" value="XM_038219883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075813.1">
        <property type="nucleotide sequence ID" value="XM_038219885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219882.1">
        <property type="protein sequence ID" value="XP_038075810.1"/>
        <property type="gene ID" value="LOC119743473"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219883.1">
        <property type="protein sequence ID" value="XP_038075811.1"/>
        <property type="gene ID" value="LOC119743473"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219885.1">
        <property type="protein sequence ID" value="XP_038075813.1"/>
        <property type="gene ID" value="LOC119743473"/>
    </dbReference>
    <dbReference type="GeneID" id="119743473"/>
    <dbReference type="OMA" id="INIACTK"/>
    <dbReference type="OrthoDB" id="10052551at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="463" mass="52484" checksum="814F46D37B0FBF64" modified="2023-02-22" version="1">MIQDSVQTANVGGAMVKAINRKPRAFQTPGEKSYSLDAHETRLRERLLLVNRFEDARLERLQRQIASNERANIGRILRRKDHMRVTLINIASNKRKIRSNVGDFERRLKNGTNSPVFALELERIRRKEQELSGLSRRLQAPNSQLLAAHVHDELRSIESRLDTNPSRLVTSQAPSVAETHTPGQPHKKHDPVTETSHQPSEQTDTMPINDMDDRLNEVHAKMSQANISKPNNSDLLHGNQDRNFPVTLPADLEQPKTHPTESHNRINPVSNSETPVQLKDVPENTVVAVEMPVRELPPLRATTKSKKQRYLALMQQKLSRTANHRGGEPEISNSALQRERHAKKRVAELKVKTREDIQGRRTADSDDSLGSIKQQEAVTRLQATRKGSILPSVGEEPERSRARARENARALARKRRQQRLATDSAATGSVSLPPLRIDLDVLKELKESRLRHRNQSHKLPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK87</accession>
    <name>A0A914BK87_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075867.1">
        <property type="nucleotide sequence ID" value="XM_038219939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219939.1">
        <property type="protein sequence ID" value="XP_038075867.1"/>
        <property type="gene ID" value="LOC119743518"/>
    </dbReference>
    <dbReference type="GeneID" id="119743518"/>
    <dbReference type="OMA" id="WQLTMIS"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="658" mass="70751" checksum="FDB9F34B97210492" modified="2023-02-22" version="1">MRQPVKSLLRSLARTKTLDHESLVTTELSRCLGVADLTAIGVGGTLGAGIYVLAGEVAREEAGPAIVLSFLIAAVVSMLSGLCYAEFGARVPKAGSAYIYSYVTVGEFLAFVIGWSMIMDNIIAAATVGKAWSQYLDSIVNGTISTSIKANVGSFDSPWFGDYPDILAFALLIVLTFIVAVGAKMSTVVMMGLTGVNLLVIVFVIVAGAFYVEGENWTSNKGFFPYGASGVFAGAATCFYAYVGFDAIATSGEEAKNPSRAIPIAITLTLLICMVCYISVSAILTLMVPYDLLSPFAPLAEVFQQRGMPAGRYIVAIGSLLGLSSAMLGSIFPLPRIIYAMAKDGLLFRFLSRVNARTDVPVIAAVVSGIVTAIMALIFNLEQLVEMMSIGTLLSYSLVAASVLLLRYHPKTVGLSKDEVKEIAKLSKEGAPEESISLVEKSAGKYIKYTDAAAPDEATDTPDDPASSKPEEPSSRGGYGVLQNETTDPTEGEKKKARAPPTAKTYMIVVIAFTILVVIFCSLSALLAFGMDSISRIEWWSITLLCLFLAAIVCLTVVIETQPQNRMELYFKTPFVPFLPLVALLCNTYLMLKLSGATWARLIIWLVVGLSIYFAYGIRHSVENQKRKEDAPSTTMSEDPHTEGAVDESKEDEPTKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLJ3</accession>
    <name>A0A914BLJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076646.1">
        <property type="nucleotide sequence ID" value="XM_038220718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220718.1">
        <property type="protein sequence ID" value="XP_038076646.1"/>
        <property type="gene ID" value="LOC119744655"/>
    </dbReference>
    <dbReference type="GeneID" id="119744655"/>
    <dbReference type="CTD" id="54443"/>
    <dbReference type="OMA" id="QSINNWE"/>
    <dbReference type="OrthoDB" id="5915976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000111">
        <property type="entry name" value="anillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031970">
        <property type="entry name" value="Anillin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16018">
        <property type="entry name" value="Anillin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132754" checksum="5B3B27BFA25299DC" modified="2023-02-22" version="1">MDEYTERLLERTRARSENLAKKMSQSEVSPRKRRTPLTDVNSSDSEEKKVRLDASPVKSAVTRGSDMKPDTPAIPSVRSRMSKLADMRREWSTADGLELDSPQNVSAPRPRQQEAPPSTTPSAPSSRKSRFAALAASINNWEDDLDHPKHHFQHEEKPQTKKWERPKPVEEIANDPPPPKKDNGILSITPKKPARNVRFEDEEEESNKPSLGNGQGKAQMRSLPSSGSPARERNTSGDPNNGKPDGRAELRSLPTGNSPVKGIAYSRLVEKSSLQFGSSPARERNISGDPKNGKPDGRAELRSLPTGSSPAKSSAYSRLVEQKQDGAKSLSKSASGGTPGRKRIQVSLSREREPSRMEVQKHFAQEQQQQQPTPKPRAAPASTVAATSTATQQPKSSIKRLAPQPEQAVKKQALATEADADPTPKEGAASVKAYFGRHKTGAAPASPTSSKVEPRVGAMAKSIQDRLRQHQENWHSNDINTKIQEQRKKELDIIRQRWNHSGKTEPAKEETEKEQPTPMPRVTIARSVPEPEVKQDELDDPMEVTEDTINIGMMESSIEGKSSSDEEEEEEMMSEKESAVVVPQQKVVMAGGSGQGNGSATPLAPPREKAVAKTTQQPQETGPATPLAPPRPRRTNSKLLAEEEAKAQQEALSKHPHREDSVDDDDDADDEYDESDDDVQELDITDVLGDIDDLLDEAEQAMEAEKQTEAPAPTKRQEQPAAPRAVAQKPPSGHEARPQPSTTQSPNLYSIESFRKQGPKSPAAARTIIRSDSGTVEAGQGVKPVALKPIPIKAQIQTLIEEVSTQQSIIYQTSQALNLIASSVEYKGTRQEVEAERLLLIAAQRRQACLAEIQRLKTPASVREPSAVMQTAEGEAMRPCKGFVSIQDIRLPLKTEYILSSKQDRMCHSFFLLLRCREHVLATRIQTTVDGVAGDCLPFTNIAKFNNLDSDFVIEAFVFEMQNKRPKAAEEKSKQTFFSGLTPKKILANMSKDSRQGMKTPIAPSPGGPGYVRASSFTLVGAARLTLQSCRVNRFTLSKVPFNSPLEGTLHLKMTCHTNANVTESGWLTMFDDISGFGAWHRRWCVLSGGYISYWKYPDDENRKAPNGTVDLRKCITTEVAPISRILCARPNTFELVTRQAASKAVHQSRDTLVTKHEHSAVTTKHMLSADVKEDRIRWINALNKTLLDLRTWNRDAARPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN00</accession>
    <name>A0A914BN00_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-binding glutamic acid-rich-like protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077111.1">
        <property type="nucleotide sequence ID" value="XM_038221183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221183.1">
        <property type="protein sequence ID" value="XP_038077111.1"/>
        <property type="gene ID" value="LOC119744959"/>
    </dbReference>
    <dbReference type="GeneID" id="119744959"/>
    <dbReference type="OMA" id="ITIYYAS"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF15">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9195" checksum="BC79932EA8A5A68A" modified="2023-02-22" version="1">MRVHIKKKQQQIEKILDSKRVQYDKIDVSAEEDKIKKMRELIGDPSALPPQLFNGDTYLGDFAAFDVAVEEGSLEKFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQE0</accession>
    <name>A0A914BQE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078518.1">
        <property type="nucleotide sequence ID" value="XM_038222590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222590.1">
        <property type="protein sequence ID" value="XP_038078518.1"/>
        <property type="gene ID" value="LOC119745908"/>
    </dbReference>
    <dbReference type="GeneID" id="119745908"/>
    <dbReference type="OMA" id="FWINQQF"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="12">
        <location>
            <begin position="406"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="782" mass="91467" checksum="58032DD5744236EC" modified="2023-02-22" version="1">MASSAMLKDKMQLQFEDKWEGMRPTVLKLLRQENVSRGEWQDLFWDVHSVCLWDEKGAYKVHAALVDDIREFVQQAKSRVLHDQEDTTLLKAYISEWSKFFTQCNYLPKPFGPLETALTQMSAGTQQKKNVQNEDTVVRKLMLESWNDHIFNNIKQRLQDSAMKLVLAERNGEAFEKQLVIGVRESYVNLCSNVDDRLQIYRENFERAYLEATETFYKRVGPDYLRENGVQNYMKFADNKLKEEETRALRYLETCRGSNSVTALSECCVQALVSSFKEEILRECAPMIKSNETEKLNLMFRLMDRVPDGINPMLRDLEHHIMEAGLADMVAAADIIVTDSEKYVERLLELFNKFSALVKDAFNDDPRFLTSRDKAYKHVVNDTKVFRLDLPAKNKSISSKTQPESKCPELLANYCDLLLRKTPLSKKLTSEEIESKLRNVLLVLKYVQNKDVFMRYHKAHLTRRLILDTSADSEKEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQSFKELHRNNYDSVADNINIKILNAGAWSRSCERVPVSLPLELEDFIPEVEEFYRNKHSGRKLQWHHLMSNGIITFRNEIGVFDLEVTTFQMAVLFAWNQRPKDKITLENLRLATELPDSELRKTLWSLVAFAKMKRQVVLCHVEAKSPKDFTDATVFWFNQQFAVIKNGKPQKRGKINLIGRLQLNTERSGEEEKEGIVQLRILRTQEAIVKIMKMRKKITNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYMKREENNINTFIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRT2</accession>
    <name>A0A914BRT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malonyl-CoA decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079013.1">
        <property type="nucleotide sequence ID" value="XM_038223085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223085.1">
        <property type="protein sequence ID" value="XP_038079013.1"/>
        <property type="gene ID" value="LOC119746252"/>
    </dbReference>
    <dbReference type="GeneID" id="119746252"/>
    <dbReference type="OMA" id="PIDWSTP"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.150:FF:000001">
        <property type="entry name" value="Malonyl-CoA decarboxylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.90">
        <property type="entry name" value="Malonyl-CoA decarboxylase, oligemerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035372">
        <property type="entry name" value="MCD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038351">
        <property type="entry name" value="MCD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17408">
        <property type="entry name" value="MCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase N-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="219"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60699" checksum="3AF7E76A31640F14" modified="2023-02-22" version="1">MLRRFALLAVYSNLTKIKCSAPIHQHAWLATRHNPPSPRSLTNRLLSTSSVVMKDSQTTEQHDAVRRLLPDLLTPTEGGKWSPGRSLLMAEAHIRQFCSHYSNLDDTAKAKFLLALSQLCGVHHESVYKAFKNMESAQEKEEATLLQSEQRLAQMLTPGYKTLFANIGRLEGGIKFLVDMRADLRTFLHHHQQSLTSEAHLRALRETLKDMLAHWFSAGLLQLQTITWQSSCEMLQKISEYEAVHPVRGWADLKRRVGLYRRCFVYTHSSMPQEPVIILHAALTDRIPSSIKSIVGETRDHNPSKTPLALEEQEDPERITAAIFYSLSSTQMGLRGVDLGNHLIKHAVRKLQAEFPKLEMFSSLSPIPGFRSWLLAEIGRHPKGKNGAILFTSGELGDIQSLAGRSDESEMMTVRRLLSTNQWAQSEKLVDLLEQPLMRLCARYLYAEKHRGFALDSVANFHLGNGAVMWRLNWMGDLTPRGLTQSCGMMVNYRYYLDSTQHNSQAYTVEQKVSTTEQVLGLVEESRLLEQKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS84</accession>
    <name>A0A914BS84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhophilin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RHPN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078825.1">
        <property type="nucleotide sequence ID" value="XM_038222897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222897.1">
        <property type="protein sequence ID" value="XP_038078825.1"/>
        <property type="gene ID" value="LOC119746101"/>
    </dbReference>
    <dbReference type="GeneID" id="119746101"/>
    <dbReference type="CTD" id="114822"/>
    <dbReference type="OMA" id="PPVHDYM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11633">
        <property type="entry name" value="HR1_Rhophilin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06712">
        <property type="entry name" value="PDZ_rhophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="7">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="80050" checksum="AF61F7DBCACE30AC" modified="2023-02-22" version="1">MLENGGSENKDTHDTGPRRKGCDPLAQTVRGKLQNRRQKLNGQINKEMRMRAGAENLFKAASNRKIKEQVAMELSFVNSNLQLLKEELAEINSEVEAYQNDTFLRSVPLIPLGLKETKDIDVKLVFQDYILEHYSEDGANYEQEIQEFMDIRQAMRTPKRNAEGVDLLFEYYNQLYFIENRFFPADRHTGIYLTWYDALTGIPSVQRSIAFEKGSVLFNVCSLFTQIGARQDRSMPEGIQEAIANLQCAAGGFGYLAANFSHAPSMDMSTPVLLMLEALMMGQVQECIFERRVLGGIAEDIQTSFEIAQEAAVVSEAYSKVHQLMMHPKVKDYVPYSWISLVLVKSQHFKASSHYYAAMGYSDRHSTYDQATLERVFPTVYDEHRTLQVPRSQQERKRLSKAHIRQALILHEEALGVHRLSKMLRKIDTLQEVLRQSTDRSMNCYTELDEEDDFFEMMDVPDIKGKAKQVPEPTAIDFTRVTVNDIFHKLGPLAIFNSRNNWSAPRMVDIQRGVEGFGFTVRGDSPVIVASVDPGYVASASGVKEGDFIVGVNDRSVKWAKHGEVVKEILSSQRLRIELVTPLGNGVLHPQDKRRLNSSDSAGSSLTDMNGSITSGSSSKDRRQPSPKKSAKDVPDGSRSLGRGKSPGRAKSPGRMKGPESVNNLGSKSLPRGATVNANGSSGMGKKKERGHKGKGSSEKEGVKKARGVLNSKAGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSH2</accession>
    <name>A0A914BSH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ABHD8</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha/beta hydrolase domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Late endosome membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lysosome membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038079129.1">
        <property type="nucleotide sequence ID" value="XM_038223201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223201.1">
        <property type="protein sequence ID" value="XP_038079129.1"/>
        <property type="gene ID" value="LOC119746320"/>
    </dbReference>
    <dbReference type="GeneID" id="119746320"/>
    <dbReference type="CTD" id="79575"/>
    <dbReference type="OMA" id="PEPCQLF"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000017">
        <property type="entry name" value="Abhydrolase domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="426" mass="47868" checksum="4F3165443439D75C" modified="2023-02-22" version="1">MTTRSSSFGPQRSHRVAPDPSSNETLNIIEVRKGRWLHVQHILPEQRKQTKRQFVAAPELEELGETAEECREHDGIRGPENDVNCLASKPCNVDFNASTRQQTTATTRQISLRDRNLEKLARDSDGSILSNQSYPDSASQSSLHSIMEDGNTAFFFIHGVGGCSDLWRHQIMYFVSQGYEVIAPDLLGHGFSRAPHQSKAYSFGEHADDIMTVFDRYCKKRNVLVGHSYGACFCAKIARERARKVAKVVLISGGGPVPLQPEPCQLFCLPSCVLACIKPIITSCFVSQAFHKDSKHSKEEKNHSFDVPAYVLRATMQGQNWHEGNEEYHASLRASVLLIYGMQDDLVLLDDEIWMNETIYASQLETLENASHMVMIEQPDKVNQLIHSFVLKDTMVHRRGAPKRSMSCRSTKLGSHGKTMPHVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075FFS3</accession>
    <name>A0A075FFS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Curr. Biol." volume="24" first="1421" last="1428">
            <title>An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.</title>
            <authorList>
                <person name="Mori M."/>
                <person name="Somogyi K."/>
                <person name="Kondo H."/>
                <person name="Monnier N."/>
                <person name="Falk H.J."/>
                <person name="Machado P."/>
                <person name="Bathe M."/>
                <person name="Nedelec F."/>
                <person name="Lenart P."/>
            </authorList>
            <dbReference type="PubMed" id="24909322"/>
            <dbReference type="DOI" id="10.1016/j.cub.2014.05.019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KJ776755">
        <property type="protein sequence ID" value="AIE90094.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068070.1">
        <property type="nucleotide sequence ID" value="XM_038212142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068071.1">
        <property type="nucleotide sequence ID" value="XM_038212143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075FFS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212142.1">
        <property type="protein sequence ID" value="XP_038068070.1"/>
        <property type="gene ID" value="LOC119737654"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212143.1">
        <property type="protein sequence ID" value="XP_038068071.1"/>
        <property type="gene ID" value="LOC119737654"/>
    </dbReference>
    <dbReference type="GeneID" id="119737654"/>
    <dbReference type="OMA" id="ECFICLR"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000030">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIE90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="41149" checksum="C4592F15DFB6EA33" modified="2014-10-29" version="1">MSNNEKFNFELGPITCHAWNKDRTQIAISPNSHEVHIYAKKGSNYEKLYTLSEHSQRVTSIDWAANSNRIVTCGTDRNAYVWTLNGSGGWKPTLVILRINRAATCVKWSPLENKFAVGSGARLISVCYFEQENDWWVSKHIKKPIRSTVTSLDWHPNNYLLAAGSADFKARVFSAYIKEIEDKPEANSWGKKMPFGNCMQELSAGGYGGWVHSVSFNADGTRLAWVGHDSTVSVVNSMADCRTGVLRSGNLPFLTCEWAGHHSLVVAGHDCELILFNVDDSDKVTFVGRLGVVKKKESGNLSAMAKFQQLDKKATTDQDTARSSVHQNSITQISIHTGGKENISKLTSTGVDGQVVIWNYKSLESAVAGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A193GS57</accession>
    <name>A0A193GS57_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrin-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="J. Cell Biol." volume="212" first="815" last="827">
            <title>Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes.</title>
            <authorList>
                <person name="Borrego-Pinto J."/>
                <person name="Somogyi K."/>
                <person name="Karreman M.A."/>
                <person name="Konig J."/>
                <person name="Muller-Reichert T."/>
                <person name="Bettencourt-Dias M."/>
                <person name="Gonczy P."/>
                <person name="Schwab Y."/>
                <person name="Lenart P."/>
            </authorList>
            <dbReference type="PubMed" id="27002173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KU512202">
        <property type="protein sequence ID" value="ANN83889.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055532.1">
        <property type="nucleotide sequence ID" value="XM_038199604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A193GS57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199604.1">
        <property type="protein sequence ID" value="XP_038055532.1"/>
        <property type="gene ID" value="LOC119727635"/>
    </dbReference>
    <dbReference type="GeneID" id="119727635"/>
    <dbReference type="OMA" id="NDFLSIM"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000070">
        <property type="entry name" value="Centrin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ANN83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="19715" checksum="9FD1C87B231CB5DE" modified="2016-10-05" version="1">MTSRYTKTSMGGGQRKKTGPKPELTEEQKQEIREAFDLFDTDGTGTIDAKELKVAMRALGFEPKKEEIKKMIQDFDKENTGTIDFNEFLTMMTAKMSEKDSREEILKAFKLFDDDNTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIMKKTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0T8</accession>
    <name>A0A913Z0T8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045514.1">
        <property type="nucleotide sequence ID" value="XM_038189586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0T8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189586.1">
        <property type="protein sequence ID" value="XP_038045514.1"/>
        <property type="gene ID" value="LOC119720066"/>
    </dbReference>
    <dbReference type="GeneID" id="119720066"/>
    <dbReference type="OMA" id="HEGWMTE"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915614" description="Cathepsin L" evidence="7">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="117"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37387" checksum="5F31528CA1122F55" modified="2023-02-22" version="1">MMRVAVFCALMVVALGMPFNFNTDLDGEWELFKKVHNKRYSGFGEEANRRSIFESNVKLITMHNLEYDLGNHTYRLGMNFYGDMTGKEFTQVMNGYKTRANPPKATMTFREPQNVQYPTTVDWRTKGYVTPVKNQEQCGSCWAFSATGSLEGQNFAKTKVLPDLSEQNLVDCSYVEGDDGCNGGLMDDAFKYVISNKGIDKESCYVYKAKDENKCHYNASEECITGHCTGFVDVPTGNETALMAAAATIGPISVAIDASHNSFQLYSEGVYNEPECSPTELDHGVLVVGYGVDQGKDYWLVKNSWGASWGMQGYIMMSRNKNNQCGIATSASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1L6</accession>
    <name>A0A913Z1L6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045769.1">
        <property type="nucleotide sequence ID" value="XM_038189841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1L6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189841.1">
        <property type="protein sequence ID" value="XP_038045769.1"/>
        <property type="gene ID" value="LOC119720227"/>
    </dbReference>
    <dbReference type="GeneID" id="119720227"/>
    <dbReference type="OMA" id="RTDTCIC"/>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000003">
        <property type="entry name" value="DENN domain containing 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000001">
        <property type="entry name" value="Putative DENN domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="10"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="896" mass="99583" checksum="34BEB5980BAE92DB" modified="2023-02-22" version="1">MDCRLKENPETIFVAFFEVAAPADKGSAPQIVSQFPADFNDVAVTKELPKFCFPCDLSTYNIAGQFFTFVLTGLDNKQRFGFCRHPPGAAKCLCILSYLPWFDIFYKILNQLAELKLHKQKDICQQLIVNLYESEVPDAYKQFSISIPVEGDTPVEIKFTGPDSKSLPRIPTNRNIMEYFNAINPTNMMILFVSLLYERRVLIVSDKLSRLTACVHSAASLLYPLYWQHIYIPVMPAHLIDYCCAPMPFLVGVHSSFMPQVKKMALDEVVILNADNNIIETPFEDLQTLPPEAVSQLKKNLKNTELCNGDGVARSFLKVLVYLLGGYREAIRSKTVTGNEYVLDRDVFVQCRSTHMQPFLEKLLQLQHFTQFIDSRLQLIKSGQPINDLFEEELEIARIDGSLSSKNLKEQLKIHLSTVKTDGRKMLKDAQKNIQQKMIQAQGSIRPKANPEAMKLVLKQGRDFANKHYSGLKTKLIKGKETEDLDMSRRHNNRQHSYLDISLPLPTSSAPSSPSNSPQNSPIPSRTTVDVRRKTTSNASRRISEENARPMTVAGLPNRRTSNDSNPPTLPLKSKTYRHPSQGDRDSREEGSRRETSSDMNLMDDMEQLLRKIGSKEDLTESTTNETTSAADDAPIPMPRRRRVQRDSSASKIVGQAIQRPLIPPPPIPPRRERRHGSQERLVDISNGEEAAREVALSQVQGTAVQNALGVDCEDHTLVFQSVHLNNNALAGYVPEGVPSNSSAQTLLADYGLNFGASAAAPTDATSSPTHHLSMPGLRATNSSPNLQSFNRSTSGPPQILVQQVLVQQPPASTLPDLLNPTNTVTRQSGSSVSTATASAVKSPPAHPFQLQQTPLQPTAASQNPFQQPSATDPKDPFADLVSFQREGVANPSWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2D8</accession>
    <name>A0A913Z2D8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045993.1">
        <property type="nucleotide sequence ID" value="XM_038190065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2D8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190065.1">
        <property type="protein sequence ID" value="XP_038045993.1"/>
        <property type="gene ID" value="LOC119720400"/>
    </dbReference>
    <dbReference type="GeneID" id="119720400"/>
    <dbReference type="OMA" id="DADFNEC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087625" description="Delta-like protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="15">
        <location>
            <begin position="174"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="514"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="847" mass="93528" checksum="D1B09123ECF6CEA0" modified="2023-02-22" version="1">MKFVLLLTALLSHVFLLVWATASVQFKFVSFYNSDHNDYDGGCCDDVIGGCDNFCDNYFFVCIDGDDTGPLGTSCDMAAITTEKLHEDNDNFNFPSTIPNAIANPYTIRVDSWSGSMQVFVRVWDLDTQNADDEIDRDRRTIYEAAARNLSSATWQQYSLGSRSQIDFSFEVRVYCDSYYFGSDCSVYCIPRDDQYGHYRCDTNTGAKICYSGWEGTTCNIDVDDCASTPCKNGGTCHDHVAYFTCACPPGFVYADEFCEYDDCAGQPCQNGATCNDLIGQFKCVCPLGYFGDLCEVDIDYCINQTCANNGTCVDRVDGFHCLCETGYEGLLCDVETDECSSSPCLHNGTCHDLIGKYQCACQEGYEGTHCDLETDECLSSPCRNNATCEDELAGYHCHCVDGYEGDTCEMDIDECASFPCYVNETCVNEINGFWCLRLNLCDYDPCMNNATCVDDYPGFICECAAGYGGKTCDQDIDECASSPCLHQGTCTDHLDGYTCLCPPGYGGEKCHSETTECNSSPCLNGTCWDLINGYVCNCTAGYAGVLCQNEIDECASSPCEHGTCVDELNAYRCECDVFYEGTQCDTVIDKPCALRDPPCQNGTCENTNSANDYNYKCTCDDGFYGTNCDIDSKLYGAVVFMIGKLEDKSAYETKLANLLQKLYALHSRVRRDTGETVSVEIILTEDYVKSTDSSPLTKVTFLAWTESGYLQKDTIEAWIDGASTDLPAQYGLDIYKGSAEPFTGNPSENWIGSNWYIILLIVVIVASVVIAAGFIYHKGYINRAKDAVIKYQGRDRGQSALPLNLETTYNTRIGEVDIAHSTRIRDDAPTLPKRPDLPNMVEGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2G1</accession>
    <name>A0A913Z2G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046018.1">
        <property type="nucleotide sequence ID" value="XM_038190090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190090.1">
        <property type="protein sequence ID" value="XP_038046018.1"/>
        <property type="gene ID" value="LOC119720425"/>
    </dbReference>
    <dbReference type="GeneID" id="119720425"/>
    <dbReference type="OMA" id="ATICTTN"/>
    <dbReference type="OrthoDB" id="6102375at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="190"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="273" mass="30181" checksum="71433F6184B3F247" modified="2023-02-22" version="1">MLKEGNRLHWRLGSEGDMCLLFLVTQLCCFQYVHCGFRAISLSGKPTSQSTTHSSPFPSYKAIDGIPSTFAHTIDDGGDPHPWWKIDLQNEHCVGQITVQIRLDCCGLNRFLGTVVRAGLSANYAENRPCSSPATAAQSSQGTVTEFPCDTPRMARYVSLDIDPSSSGVTTPILQIAELTVEEHTTIRACDPRIIQSTKFERLHKKGLIDNPNPLSTKTTRSLTTCADLCTKETDCFSFDFGKSLKQCRLYNLNSTDIVMTPNDEFAVYSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z678</accession>
    <name>A0A913Z678_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047227.1">
        <property type="nucleotide sequence ID" value="XM_038191299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z678"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191299.1">
        <property type="protein sequence ID" value="XP_038047227.1"/>
        <property type="gene ID" value="LOC119721293"/>
    </dbReference>
    <dbReference type="GeneID" id="119721293"/>
    <dbReference type="CTD" id="91647"/>
    <dbReference type="OMA" id="WDPVLHW"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31827" checksum="2F6F8A398BAB419F" modified="2023-02-22" version="1">MSGSIFLSRSCQSLRRILQGSSHPFFMNNVKRFYRERKRFYKNVSISQSGKSFEINLDRRKVKTPAGQLLVIPNEPLAIAVATEWDNQGDVIKQHTMHLTSLCNTAIDNPSTRNKQQVIRAILHYLDTDTVCYRLQDPPELFALQTNEWDPLLDWINERYKVEVSSSTSITGPEIPDATRQTLGHHLETHSDWALVGYENTVSCLKSVVLTFALMDRRLGVEEAVTLSLLETEFQTARWGSVEWAHDTEIADLKARVAAASLFTQLVSGSHEVKQKQPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6I9</accession>
    <name>A0A913Z6I9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Sialidase-1</fullName>
            <ecNumber evidence="7">3.2.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Lysosomal sialidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">N-acetyl-alpha-neuraminidase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alpha-(2-&gt;3)-, alpha-(2-&gt;6)-, alpha-(2-&gt;8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.</text>
            <dbReference type="EC" id="3.2.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.18" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038046435.1">
        <property type="nucleotide sequence ID" value="XM_038190507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6I9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190507.1">
        <property type="protein sequence ID" value="XP_038046435.1"/>
        <property type="gene ID" value="LOC119720701"/>
    </dbReference>
    <dbReference type="GeneID" id="119720701"/>
    <dbReference type="OMA" id="IRSYDAC"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.10:FF:000003">
        <property type="entry name" value="Neuraminidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF25">
        <property type="entry name" value="SIALIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 26" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872784" description="Sialidase-1" evidence="26">
        <location>
            <begin position="38"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="27">
        <location>
            <begin position="75"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00040509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00041332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00041413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="396" mass="43601" checksum="F5668E536E4E1F22" modified="2023-02-22" version="1">MARDAAGSFLCGFGRASCQKFFAICLLSLLLSHVTLAQPSAKVNPSIASQRPLWRAGEAEVVIYRIPLLSYTPGGRLLAVAEARKYTGGDAGPKFMVIRRSLDDLGDEWEPMQVIVDDGYLTFDGLNLGNIIVDDEKAIIFIMFTVCNHHDGCDVTSTKLIRSLDDGVTWSKAMNISEQIGTQVFAPGPGSGFQKKYAPNKGRLVSCGHGSLYTDGIYCLLSDDHGMTWFWGGSVIGIPYGQEKVEGDFVPDECQGVELPNGTIMINARNQYRFKCPCRIVAWSFDGGETLPIQDVYQVEALIEPACAAGLLYHRNVLLFSNPKSTTARVALTLQWSYDNGTTWNGEYQIWDKASGYSTMTAHPGASQYIFILFEKGITLTTESIEFVRVSLYEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6P4</accession>
    <name>A0A913Z6P4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047483.1">
        <property type="nucleotide sequence ID" value="XM_038191555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6P4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191555.1">
        <property type="protein sequence ID" value="XP_038047483.1"/>
        <property type="gene ID" value="LOC119721475"/>
    </dbReference>
    <dbReference type="GeneID" id="119721475"/>
    <dbReference type="OMA" id="WNQPEVH"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111800" description="Glycosyl hydrolase family 13 catalytic domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="33"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="587" mass="67451" checksum="1CD1C5563F23D2F9" modified="2023-02-22" version="1">MAAKHAFLLFVFISNTVVGFRWNEWWKDTIVYQIYPRSFMDSDGDGVGDLAGITSRLEYFNDIGVGTVWLNPVYKSPMADFGYDVADFKDIDPIFGTMADFDELISKAHRLGLKLVMDFVPNHTSDQHPWFVESKKNKDSTNRYRDYYVWVDPKKNCSDPPEKCIPNNWVGLLGGTVWEWVPERQQFYLHQFLKKQPDLNHRDPAVQLEIIGVLQFWLEKGVDGIRVDAIRHIYESEDLEDEPINPDYTPIPGERPQYHSLIHNKTADLPEVHELMYVWRRVLDKYSGEPNYRFMATETYDTHKALLPYYGTPERPEADFPFNYVLTQLKRENLSGTKIFELVNDWMKDLPSGKWPNWIICNHDNFRIPHRIGANYARALNVLELLLPGTPKTYYGDEIAMGDIWVTYNESRDPFAKNNPNHWKEYTRDPERSPMQWDRSSHAGFSTTIGDTWLPVNQNYLSGINVADQKADNTSALALYTKLAALRKDAPAFQTNHLKYVVVTEKIFSFLRIPDTPGLNSFLIIVNAGTSESTDDYSAALEEMMLKAEGDTGVIEVSSNMDRNGNLQEMNGISLAAGEALVIKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z727</accession>
    <name>A0A913Z727_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047527.1">
        <property type="nucleotide sequence ID" value="XM_038191599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z727"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191599.1">
        <property type="protein sequence ID" value="XP_038047527.1"/>
        <property type="gene ID" value="LOC119721522"/>
    </dbReference>
    <dbReference type="GeneID" id="119721522"/>
    <dbReference type="OMA" id="IVPEREC"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036976155" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="428"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="665" mass="72844" checksum="2EE1ABF403DC388A" modified="2023-02-22" version="1">MLLKVCVLVVAFAVACNACGDPAITPSKLSVVGGTEAVPHSWPWQVSLQLRKIFGGYAHHCGGSLINNEWIVTAAHCVDGREATYNWKIWLGAHDNYYLESGTVEKTVSKVVRHAQYNGAIITNDIAMMKLSSPVTLGNTINTVCLPSRTYTSGNAYVTGWGDTQSPWPGSYPDKLQQVMTPIMNHDLCVQRMAAAVPGIPVDNTMICGGFDNGQKGACFGDSGGPFVIKNSSGKWELAGIVSWGDDPCAQVGVPSIYADPFYFQSWIQNTMATNYWEDHVPNTQLYGTLPRVSAKVRERRMRLAGHCVHHPELATSPLVIWEPIDGARSMGRKRLSHVDQLKRDAAQQDSIELRKLMLDRDAWKVTIRGSREGCVLNVENFTIHQVIIVLFTHVFIMLLKVCVLVVAFAVACNACGDPAITPSKLSVVGGTEAVPHSWPWQVSLQLRKTFGGFSHWCGGSLINNEWIVTAAHCVDGKEGTYNWKIWLGAHDNYYLESGTVEKTVSKVVRHAQYDSVRISNDIAMMKLSSPVTLSNTINTVCLPSRTWTSGNAYVTGWGDTQQWGQGSYPDKLQQVMTPIMNHDVCAQKLSIDNTMVCGGFANEEKGACSGDSGGPFVIKNSSGKWELAGIVSWGIIPCAQPGIPSVYADPFYFQSWIQNTMATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z877</accession>
    <name>A0A913Z877_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Roundabout</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047942.1">
        <property type="nucleotide sequence ID" value="XM_038192014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192014.1">
        <property type="protein sequence ID" value="XP_038047942.1"/>
        <property type="gene ID" value="LOC119722032"/>
    </dbReference>
    <dbReference type="GeneID" id="119722032"/>
    <dbReference type="OMA" id="DALWIDH"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000600">
        <property type="entry name" value="Contactin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF37">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036719403" description="Roundabout" evidence="15">
        <location>
            <begin position="38"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="241"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="431"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="542"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="656"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="772"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="867"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1226"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1497"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1562"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1234"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1250"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1332"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1357"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1381"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1398"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1513"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1576"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1591"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1671" mass="180324" checksum="AC896DE74A32EE59" modified="2023-02-22" version="1">MKHHWTSANDTKKTNRSSLLGLSVLLWKCSLISIVIGGPGGNRREDYAPRITEHPQSVIVPKGEPTTLRCRADGRPDPTLTWLKDGERLDLLSGDGHRSMLNPGELFFLRVIHSKGNNADVGTYQCVASNYLGDTYSNNATLEVTYIKDDFRREPVSTEAEAGEPVVLECQPPRGYPEPTVTWSKDGEDVIVDGDRVKVLQDGNLMISQSRASDAGSYVCTASNQMGSRSTEPAHLTVKAPPLLVAPVQDTVVAPGTTVMIRCQVIGDPVPVVTWTKEGGELPMGRYTILEDNSLRIRQVTQDDEGVYICEAVNSNGRMQDDMTLTVSVIPTFTQAPVDRTVELHHTASFQCQATGSPPPAIFWKKEGSQEELLFIGMESGRLRVTSNGELHISDVREEDEGYYVCSAHSGSSMAEARAFLRVIASVSQPPPIINYGPSNQTLIVGTVALLTCETAGHPAPSVRWTKNGAPLQASDARFTVLDTGRLQISGLFLEDSGMYSCIATNSSGQTSWRAYLRVIERSEASGIPVLQAPNIHELPASPGQPVASNITRTALSLRWLAPSRSTPPLSPVTHYRLEYFSHEVAQEWQIVPTPCIGETCLVQQLRPGTTYLFLVRAVNDRGIGPPSPISQPITTRDDMSAIPSEQTTLIEEKLAETRVEITNAMVLSQTAVKVLWEVRQHREFIEGYHLKYHADSGSNGFTMQTVLGSTNKIITGLMANTGYTITLQPFNSRFNGPESDAVSVVTLSQGDQLQESPIDNPVLQGKLDTCGTSIVSIEAVGSTSLKITWRVSKNEPYIDGYHIKYSVRDSNDVIMQTVTGSSVKTLTDLTPWTWYRVSVQPFNGLYLGPESTHQDAKTQSAVPTGAPHNVHVVTNGTAAILVSWEPPSASTVQGVIAGYNVYCLANTTALHKNVTCPADQRSVRVTGLLIGKVYMVKVAAYTTAGAGPRSSAQPVYITAGGVIGGGDVDDDDSSVMGDNGSIVTQPWFIASLAVFFLLILLCITVFVWRRHVQYKLAGNISKGPISRDNAAAAHNMGIGSSGQFIPSNHSSVQSSLQRGQGWVNPAQRPLPSTVGLLSDSSDHHGNRACIPIGSASSSLSRAEYLQPNNTAYWLLEAYDPESGTLRQYDTQQLGPDGRRCHQYHPSHSCYGSGGPVYAVVDNADDEDEDDDEHGADMIHGPHTALTLPMPRCPEHVKEKLTVSNSLPPHVTEPYASTTLIMPSNMVDMRPPCSHSGSSEQSAASTHSAARIDARGRHTAADNGAYSSSGGSTQQGDRASRKKRHRGGSKQPARNWTELLPPPPEQPPTDIDSPTGSACPAPPCSHANANPHMDHGKNRQDMERSKKKGPTPPLRQCCSSPPVSTSDRQHTLPAVAHKPLPTNSVPNQLDSNRSGTPADHRQQPHSKTHDRPSDPDHTQRGVPYLASKRLFEDPRHEQLGKELLEFNDDMSQSEILSDNDDMAGISAATALNADQGLHANHGDYMANRNQLPHMLQTEDDTESADSCTDAMLGSWSSMNGSSSSGRHSSVSESSEGSFFTDADFASAVAAAAQNSGMQVIGSTVTDPRAGKKHGRHDAQQSRTDRAHPATHTGSKPSHSILTTFKPMAGTGRETGGSTKKAKTKPLAGTGRETGGSTKKAKTKPLVLQDTNNVGLTVTANPLAFAMEDSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9K4</accession>
    <name>A0A913Z9K4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038047691.1">
        <property type="nucleotide sequence ID" value="XM_038191763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9K4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191763.1">
        <property type="protein sequence ID" value="XP_038047691.1"/>
        <property type="gene ID" value="LOC119721806"/>
    </dbReference>
    <dbReference type="GeneID" id="119721806"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036781416" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="149"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="43636" checksum="60C94EAF2A6BC9EE" modified="2023-02-22" version="1">MCTFWVISPSVLWGLLLCLTAVEAQPRIEIAPQTTTVVAGRTAILHCKVVNKGMYTVNWIKHHGVTSRSAGELGCSTERGEPAARLNWTLDGAELPVKLTESTPGFIELNFARNVTVADDGRSFICTLTHELLPEPRMCEVGPLDVVYPPVETTISATPLVPKEGGTLFLICGATANPMSDISYTWYITPPSPEIGESQASRVDRPGATGNLWVLRDVAYEDEGTVVVCEARNGLGALNASFAIDVFKKTTPPPRPTPPIVVPTKAPPPATPEPKSGSLITAPYVIILILIAAALLLLTIALVIFVVKRKKRPTQAVITVTDLDNIHADVHSLASFGGISRTGTPYLDRVDYELNRSRSHSRDMFDSVSLDSASALVNINRSHSRDSPTHRKYSVDSLGKTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA17</accession>
    <name>A0A913ZA17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="5 18">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_038048474.1">
        <property type="nucleotide sequence ID" value="XM_038192546.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192546.1">
        <property type="protein sequence ID" value="XP_038048474.1"/>
        <property type="gene ID" value="LOC119722429"/>
    </dbReference>
    <dbReference type="GeneID" id="119722429"/>
    <dbReference type="OMA" id="CRPGDFN"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000026">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="20">
        <location>
            <begin position="146"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="568" mass="64557" checksum="07247CC02F5CC40A" modified="2023-02-22" version="1">MIIRRFCAAISRFDRRFRECCICQTMKRKRKSARSSGEVCGVEESSNSTEGEDEKNSQCGADFGTVDKSHTQKKRKMRDHGDTSTEDKVDHPNPFHFFTEEKDVRQFRQDLLQWYDANKRDLPWRKWANHPDPDQRAYGVWVSEIMLQQTQVATVIDYYNRWMAKWPTLEDIARSATPEEVNEMWAGLGYYSRGRRLYEGAKKVMEELSGKMPRNAESLMKQLPGVGRYTAGAIASIAFKEPTGVVDGNVIRVFCRARAIGADSTSQTVQTAIWSLANALVDAERPGDFNQALMELGATVCTPKAPSCDKCPIRNRCRAFQHEEKLKRAKKEGLEKNIAGKGTAKSYTLPDIECAADNCQLCIPADSEWDIEQGVMNFPRKPKKKXPRQEKTAVCIVQKKCKDGVTSEFLLVQRPEKGLLAGLWEFPSVKTDDHWLAVQRVKAIDDYLSDGLGMRLAEKHDRHAIGEVVHIFSHIEQTYCVETFSVIENDVLEQTTDSSQRYRWLTAEEFATAAVSTAMKKCFGAYQKWINPPKVTQKKIKFDSSGTGDSKKQSALDTFFKPVPKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCP2</accession>
    <name>A0A913ZCP2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048705.1">
        <property type="nucleotide sequence ID" value="XM_038192777.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048706.1">
        <property type="nucleotide sequence ID" value="XM_038192778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192777.1">
        <property type="protein sequence ID" value="XP_038048705.1"/>
        <property type="gene ID" value="LOC119722595"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192778.1">
        <property type="protein sequence ID" value="XP_038048706.1"/>
        <property type="gene ID" value="LOC119722596"/>
    </dbReference>
    <dbReference type="GeneID" id="119722595"/>
    <dbReference type="GeneID" id="119722596"/>
    <dbReference type="OrthoDB" id="10119857at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="125" mass="14744" checksum="61A1C95078764D58" modified="2023-02-22" version="1">MKCNDAMDLCQHFFILPLYSHEVLAAFEYTKNPYKLQVGVREGIQSRDWRFFQDDCDGKYRWCESVDSEASWDYDESRRYTTCFENSFDDISIPEGCAKPLAVVTYDSHHYDDKVRGQQMLLCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDN1</accession>
    <name>A0A913ZDN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="4">1.3.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">24-dehydrocholesterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">3-beta-hydroxysterol Delta-24-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5alpha-cholest-8-en-3beta-ol + NADP(+) = zymosterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16608"/>
            <dbReference type="ChEBI" id="CHEBI:18252"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.72"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:36401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>lanosterol + NADPH + H(+) = 24,25-dihydrolanosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33919"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:33920"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038049609.1">
        <property type="nucleotide sequence ID" value="XM_038193681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193681.1">
        <property type="protein sequence ID" value="XP_038049609.1"/>
        <property type="gene ID" value="LOC119723133"/>
    </dbReference>
    <dbReference type="GeneID" id="119723133"/>
    <dbReference type="CTD" id="1718"/>
    <dbReference type="OMA" id="TKWLYAH"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000032">
        <property type="entry name" value="Delta(24)-sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="27">
        <location>
            <begin position="61"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00056986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00078485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="519" mass="60257" checksum="F4A140709061D793" modified="2023-02-22" version="1">MSYELWATLCVAPIISLLLWIRVKGLEYTIVHQRWIFVCLFLLPLSVVYDAFSFVRNWIVFRMNTAPLKHDERVKDIQRQVRQWKADGAKRPMCTARPGWQTVSLRVGKYKKTHHKININLVDILEVDTKRRVVRVEPLVNMGQVTAMLNPMGWTLPVLPELDVLTVGGMVMGVGIETSSHKFGLFQHTCVAYELVMADGSLVRCTKDENPDLFYAVPWSYGTLGLLVAAEIQIVPAKKYVKVEYKPAHSMDEVIKVFSEEITKKSGNEFVEALMYNKEEAVVMTANITDNAEESKVNSIGNFWKPWFFKHVQSYLRTGPGVEYIPLRQYYHRHTRSIFWELQDIVPFGNNLLFRYLFGWMVPPKISLLKLTQGETVRKLYEQNHVVQDMLVPLGKLRESLNCFDKELDLYPLWLCPFLLPSVPGLVHPKGNKDEMYVDLGAYGTPKRKGFHFVETTRRVEEYVRSVHGFQMLYADSHMTREEFRQMFDHTLYDNLRDKLGCKKAFPEIYDKISKAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDU5</accession>
    <name>A0A913ZDU5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049951.1">
        <property type="nucleotide sequence ID" value="XM_038194023.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049952.1">
        <property type="nucleotide sequence ID" value="XM_038194024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059689.1">
        <property type="nucleotide sequence ID" value="XM_038203761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066869.1">
        <property type="nucleotide sequence ID" value="XM_038210941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067396.1">
        <property type="nucleotide sequence ID" value="XM_038211468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069388.1">
        <property type="nucleotide sequence ID" value="XM_038213460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069691.1">
        <property type="nucleotide sequence ID" value="XM_038213763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDU5"/>
    <dbReference type="SMR" id="A0A913ZDU5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194023.1">
        <property type="protein sequence ID" value="XP_038049951.1"/>
        <property type="gene ID" value="LOC119723405"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194024.1">
        <property type="protein sequence ID" value="XP_038049952.1"/>
        <property type="gene ID" value="LOC119723406"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203761.1">
        <property type="protein sequence ID" value="XP_038059689.1"/>
        <property type="gene ID" value="LOC119730739"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210941.1">
        <property type="protein sequence ID" value="XP_038066869.1"/>
        <property type="gene ID" value="LOC119736914"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211468.1">
        <property type="protein sequence ID" value="XP_038067396.1"/>
        <property type="gene ID" value="LOC119737268"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213460.1">
        <property type="protein sequence ID" value="XP_038069388.1"/>
        <property type="gene ID" value="LOC119738553"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213763.1">
        <property type="protein sequence ID" value="XP_038069691.1"/>
        <property type="gene ID" value="LOC119738802"/>
    </dbReference>
    <dbReference type="GeneID" id="119723405"/>
    <dbReference type="GeneID" id="119723406"/>
    <dbReference type="GeneID" id="119730739"/>
    <dbReference type="GeneID" id="119736914"/>
    <dbReference type="GeneID" id="119737268"/>
    <dbReference type="GeneID" id="119738553"/>
    <dbReference type="GeneID" id="119738802"/>
    <dbReference type="OMA" id="LPGELAX"/>
    <dbReference type="OrthoDB" id="1733721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13466" checksum="3671F66E8C53BE76" modified="2023-02-22" version="1">MPPKPSGKGQKKAGKAKGAPSTNKKRKRKRKESYGIYIYKVMKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKKSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE70</accession>
    <name>A0A913ZE70_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049250.1">
        <property type="nucleotide sequence ID" value="XM_038193322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE70"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193322.1">
        <property type="protein sequence ID" value="XP_038049250.1"/>
        <property type="gene ID" value="LOC119722915"/>
    </dbReference>
    <dbReference type="GeneID" id="119722915"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="91" mass="10823" checksum="9CBC8FACFEE85224" modified="2023-02-22" version="1">MAAYKGQKVQKIMVQPINLIFRYLQNRSRVQVWLYDQNNMRIEGHIIGFDEYMNLVLDEAEEFHLKTKSRKPLGRIMLKGDNITLIQNVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJI5</accession>
    <name>A0A913ZJI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051977.1">
        <property type="nucleotide sequence ID" value="XM_038196049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196049.1">
        <property type="protein sequence ID" value="XP_038051977.1"/>
        <property type="gene ID" value="LOC119724817"/>
    </dbReference>
    <dbReference type="GeneID" id="119724817"/>
    <dbReference type="CTD" id="338363"/>
    <dbReference type="OMA" id="WAIIHLF"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34971" checksum="C0EAF58CA303D5FF" modified="2023-02-22" version="1">MAKWMLTGIYCVLFVATNITNKYVLSVLHFTYPTLFQEWQTLVGVIVLFGAANRGYIKLTYDRSALLPWLPAMMFFVLSIYAGSKALSKLVVPAFVILQNIVEFPAYIIGIFLNNQPTSLPNKVSLVAGVIAALLTWITDPQRDEKDSVDGYFWMLIYILSASSFASYSSVRGSAVNLSEVEKLLYCYFFSVVALSPASVILGDILASRDFPHWYLHQFYVGCILSGVLGAALNLTGICVSRCPESSLLSGLTIANAKTMLILSSVVIFERTFTGDFALSVFLGISAYSVFTVTKTTSSTIATDELGVKHEAERLENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK46</accession>
    <name>A0A913ZK46_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052163.1">
        <property type="nucleotide sequence ID" value="XM_038196235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK46"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196235.1">
        <property type="protein sequence ID" value="XP_038052163.1"/>
        <property type="gene ID" value="LOC119724917"/>
    </dbReference>
    <dbReference type="GeneID" id="119724917"/>
    <dbReference type="OMA" id="RRMDEFY"/>
    <dbReference type="OrthoDB" id="10378706at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="290" mass="33156" checksum="52733957EB640049" modified="2023-02-22" version="1">MSKRFMWGSEQVEEFFNLLRNSYRDYLMAKELRRMDEFYEMLGSCMGTDGLVVQNFLKKIGRSYRDILLQAETCEEGGQLPERKLRGSARIYALYEEYYQMYYLGAVPSRPNDLEASGSFQQKSITSHNDRKRKHLPEAAACKRRSRSPVSEIDTKEENIVHVDDEDAANRLDGDTVPDLHLQRAGELVDHFSTEEVPTETASKKVVVENGEMSPRHSLASDAARGTTKQRQEDPKSDGVFGTTTTDFQERFLKLMENQNHILASIVDELNMIKHAVLDANGLQTITYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKB2</accession>
    <name>A0A913ZKB2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heparan sulfate 2-O-sulfotransferase pipe</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051530.1">
        <property type="nucleotide sequence ID" value="XM_038195602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKB2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195602.1">
        <property type="protein sequence ID" value="XP_038051530.1"/>
        <property type="gene ID" value="LOC119724516"/>
    </dbReference>
    <dbReference type="GeneID" id="119724516"/>
    <dbReference type="OMA" id="FIRIAMC"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF15">
        <property type="entry name" value="URONYL 2-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51460" checksum="3901828C6D4B4E30" modified="2023-02-22" version="1">MRCITRLALVGSALVAALLIHAFMNVSLSDGERHKALERQVHRMGDESTPKHSEDNRVKTVANVETQAEGVKLTNVSHPLNIFKEEGHPKIPRHQRNTDDGLEHKTGNNDKIPHRLNTDDKLVREATKNDDNPPALADQSASGENIADELHVLYQELRSDPATVSKEVMLAQKFTFIRIAMCGSQSLINPMATVAKKNVPSLTLTMVPESITKRRGEGYAFNEKLIFEYLYRYPIPYLSIGGHRFINFRRYGDFQPISLTVFADPVERFTKLFYLIRKVYMRQKRWGMKAKSNIQLRPEARNTTLARCAMLLDKNRLDSRLSQIIQRKYCGFELSSLARVMCGEDKRCSQHDATNYTLQEALKNLEDFLVVGFADDMETTVRVMERLLPFYLTGYQQEFLDQIEKETKRIHSLEVTNMLRRVLETDYVLYDAAKDRFEKLKQELKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKK7</accession>
    <name>A0A913ZKK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052323.1">
        <property type="nucleotide sequence ID" value="XM_038196395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196395.1">
        <property type="protein sequence ID" value="XP_038052323.1"/>
        <property type="gene ID" value="LOC119725029"/>
    </dbReference>
    <dbReference type="GeneID" id="119725029"/>
    <dbReference type="OMA" id="WRIATGN"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="109" mass="12837" checksum="AF7027D6E0EF9912" modified="2023-02-22" version="1">MDEIVHLNVGGCTMYTTKRSTLIRYKNSLLFKKFQLLRFNNDKVNGAYFIDGDGSIFRHVLNFLRRGRLTLPEDFKEWELLASEADFYQIEDLVEAVKAKKFQRDTYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKL3</accession>
    <name>A0A913ZKL3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051858.1">
        <property type="nucleotide sequence ID" value="XM_038195930.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051859.1">
        <property type="nucleotide sequence ID" value="XM_038195931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKL3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195930.1">
        <property type="protein sequence ID" value="XP_038051858.1"/>
        <property type="gene ID" value="LOC119724740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195931.1">
        <property type="protein sequence ID" value="XP_038051859.1"/>
        <property type="gene ID" value="LOC119724740"/>
    </dbReference>
    <dbReference type="GeneID" id="119724740"/>
    <dbReference type="OMA" id="RYMCEIQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="425" mass="47649" checksum="D9CAEC3F715D722E" modified="2023-02-22" version="1">MASNDAEEQVEVTVNDNPESYAQLENGHGEITLKPQEKRDNHNICSENVRKVIYGLILVIGIAVSWVSTTQFSKSTYSATFNAPFFMIWFTTMWTIVCYPVYVIGSFLLFKEKRKGGWRPLFREDQKIFGANGLTLRNYFKYIAPFCVCWMGTNYMYIRALGIIHVTDVTALFATNTAFVYICSWIWLKEKFILIPAKSFSVVLAIAGTVLMCYADGFEGGRAEGVVLALGSSVGAALYKVLFFRCIGKASYGQVSLFLSLLGLFDLLFFWPIMLTLYLTKVETLDWGNLPMTFLCGSATLGLVFNFLVNFGIAITFPLFIALGTFVGIPLNGVVDSLFREASFGAWKIVGGSLILIGFLVMLAPEFIQRKVACWKEGQCPCERQKLDQDEAEAEEKVELKEGAGQQEGESWQRLKQTEDDDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL47</accession>
    <name>A0A913ZL47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051771.1">
        <property type="nucleotide sequence ID" value="XM_038195843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195843.1">
        <property type="protein sequence ID" value="XP_038051771.1"/>
        <property type="gene ID" value="LOC119724682"/>
    </dbReference>
    <dbReference type="GeneID" id="119724682"/>
    <dbReference type="OMA" id="MNDSEDT"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF65">
        <property type="entry name" value="GH20068P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="339"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="377" mass="43453" checksum="1DD9DAE067C14A02" modified="2023-02-22" version="1">MNDSEDTSPNGRWRKRLISIALGCLLLTFSLGMLGGTHPRGESHIKTWSRPGTGFQLDKDKPAPPNEDSEASKDFTCDKCCYRYTTIENGILEIQSKSELMKRGCEKRLPDAMIFGVKKGGTTTLKNFLSYHPDIAFSQDELKFFTSSEDRYKGVEFYRNEMLYSTPDQISMEKTPAYSHYPKVPAMIKKVLPNVKLIIIMRDPVERAISDFVHMQVTIARKCKKKSGCNLDNSGYYIAHTFEDSVIDSNGEVNYSNLLVAKGVYVTDIQRYLKYFKPEQILALDGEAFIKNPYPAVKLVEQFLGIKDYFTRDHFYYDVQKGFFCLNKPIPNNCMKESKGRPHPEVNDETLRKLRDYYRPYNKALNDLMKVDFHWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMR9</accession>
    <name>A0A913ZMR9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052395.1">
        <property type="nucleotide sequence ID" value="XM_038196467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196467.1">
        <property type="protein sequence ID" value="XP_038052395.1"/>
        <property type="gene ID" value="LOC119725106"/>
    </dbReference>
    <dbReference type="GeneID" id="119725106"/>
    <dbReference type="OMA" id="NIRMSIF"/>
    <dbReference type="OrthoDB" id="8951579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="157"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="339"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="635" mass="68835" checksum="15890943217D69AA" modified="2023-02-22" version="1">MLPLRTSYRYPVTIFWLQVEVSTGNVVEVAEFLASQTSESQEGAKDVELVSNILANIVMAGSGDTEVTKLVLETVNNVIMSGGETPDSQAPDFNGSSSSAIIQSLESQVSLSLRQEGNFSIRQDTIHVEAVSLDPTLAQNGLSFVSVRHPGQGSPQEGSLVGTEVQTFMDSSNIPLSIDVLASVQLPRNIIDLIQSSDSDSSAKLQASFLIYADDTLFQSTSIRENRGEKNSTRKVAGSVVSLTVENTELVNLTEPVVIKFKAPDHTTSEELETIQCVSWDFELEDGVGDWSPAGCARTQLHNEQVSCNCDHATNFAILVDVKGQAPDGLIDAPAKKALDIISQVGCALSIIALAITLIIYLAIRKLRSGKSRQIFIHFCFSLFMLYVVFLAGVDAAKATTGGCAFVAALLHYLTLSTMMWMAVEARNMYVSTVKVFPEDTPHYMLKACLIAWGSPLIVLTITLAAASHHYGNEHYCFIEPGLVLYLGLLAPIGLILIHNIITFILVMRSLLKVREASHSQQISKRLQNAVAISALMGVTWCFGFLAIEGATFAFQLIFCLANSLQGVVVFIMFCVRREEVRSAIAPYLNRISRRLTIARPAKSNDTELVSTSAGPTSASSIKTFSSDVSISGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNI5</accession>
    <name>A0A913ZNI5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052675.1">
        <property type="nucleotide sequence ID" value="XM_038196747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196747.1">
        <property type="protein sequence ID" value="XP_038052675.1"/>
        <property type="gene ID" value="LOC119725349"/>
    </dbReference>
    <dbReference type="GeneID" id="119725349"/>
    <dbReference type="OMA" id="MCSANVI"/>
    <dbReference type="OrthoDB" id="10113950at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037067363" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="142" mass="16126" checksum="9D061D6C5B3B02A0" modified="2023-02-22" version="1">MECHLGMLLASTVIIFCTICSASVINDNELNILSSELSDEECRKLLSVLYERRQSLPARSRLQHIRDITGRCVLDLERWLDSEAKEGLALTELDEALRDIGKPALGHQIANEVFAEKTHSLRNLFGRDGRLASKDIFQERHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNJ9</accession>
    <name>A0A913ZNJ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052690.1">
        <property type="nucleotide sequence ID" value="XM_038196762.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052691.1">
        <property type="nucleotide sequence ID" value="XM_038196763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196762.1">
        <property type="protein sequence ID" value="XP_038052690.1"/>
        <property type="gene ID" value="LOC119725360"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196763.1">
        <property type="protein sequence ID" value="XP_038052691.1"/>
        <property type="gene ID" value="LOC119725360"/>
    </dbReference>
    <dbReference type="GeneID" id="119725360"/>
    <dbReference type="OMA" id="CTTFFCR"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF64">
        <property type="entry name" value="LINKING IMMUNITY AND METABOLISM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="917" mass="104132" checksum="46F28C390C9EEE0F" modified="2023-02-22" version="1">MDPSLLDEMDFSFSCDKCSFSTKDMMQIKIHMYEHRSLGKDPGQTVAAAGSDAPEATKEQVDPIISRDPGDDGHHAQDETPPSNKDVPNLASLSKTNTPNLVSSLPSTEERHSGGSDAPSVSGLRDEVSEQMLAEKDNSCKNVDEGVERTEGSKQCIVREATVIVARKEKAPGEDSARHQPQPQGEGEFSAQGKTGPDSIADRIQSRRRPSTKMPHEELEEKDDDYVPYQPAMSRFKRHAKRVKRRHNRSNLRVKAKLRPAVPSDRYKCQHCHFVCKFKQSLRAHTRGSHPEVYAEMIQAEKKEKEGAEEDVEEEYRILEDYNQEPSDVTEEIQSNEATDRYQCTLCETFFCRFKKDLHNHKSRVHGLPAPVYKYQSRIPDNRYRCTECDYICKFQRTLRLHCRSVHPKAVKSPEIKEKKEKKEKREKKVLESRYRCPECDFTCKFKGQLKKHKSQAHKKERPPKTMREQQCQFCSKFIQGTMHHYRRHLMTHTGEKPFKCDICDAVFGDQSRLNAHAPIHLEARNYLCDQCGKSFKRAINLRMHRKVHLVVRPHGCELCSYRCKRHDTLNLHMKRKHLKIRRVLCDTCGKKFFSEKECQLHAARKHLPRPTPFQCTFCPQAFPFAYNLRAHMKKHPEHKPFRCEFCSFESRSKASLQDHEKMHTGEKQKKCEMCDYTTSTSSNLYKHRKRQHGVVVHRNKSPRVLSPSQDRPSILLQPAILQNSPQASVPATPLCSTSATPQPHPMLPTPEILHAHHMHIQRHLQGALSPIPGQIQGSPSPALAQSVTQSVTVPTSSGHVDLRNVQAYEEIDLKDRRAIIYGREKSLIGSVITEALAEARNVVQSELYGSGHVIQSTVAPPQAHHQPGLPVTTTMAPPNGGVVSTEGIIHGAIQTSTGISPSGASGIFNSIMNIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNU7</accession>
    <name>A0A913ZNU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA-binding protein SMUBP-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053407.1">
        <property type="nucleotide sequence ID" value="XM_038197479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197479.1">
        <property type="protein sequence ID" value="XP_038053407.1"/>
        <property type="gene ID" value="LOC119725883"/>
    </dbReference>
    <dbReference type="GeneID" id="119725883"/>
    <dbReference type="CTD" id="3508"/>
    <dbReference type="OMA" id="TIIHGPP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001146">
        <property type="entry name" value="DNA-binding protein SMUBP-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="18">
        <location>
            <begin position="709"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="17">
        <location>
            <begin position="953"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="836"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117384" checksum="433EA40C545E08DB" modified="2023-02-22" version="1">MALREFVKKQTELLSLEREAEIAETSALVENVPLKELQRRGVCLLKLHPASQSTGLYGRTLVTFAPNKGHGDGTLPTHNISSGDIVGVSSSHGGGASSTDEPSGIVSRVTQSSVTVAFDHKDTDGPVTFEHEGLYRLTKLANDVTYRRLKRALSDLDSYTAGRASHLVDVLFGEADISSPLLPTNLSQEPVASTELQFFNENLDQSQREAVTFALCQRDIAVIHGPPGTGKTTTVVEIIRQAVKHKLKVLACAPSNVAVDNLVERLVAAKVRVVRLGHPARLLHSIQRYSLDAILASSEEAGIVRDVRKEIDQTRTQLSKSKQGSEKRRLRDEAKTLRKELREREQHAIREILQRADVILATNTGASPSGPLGHLPKDFFDLVVIDECAQALEASCWIPLPLAPRCILAGDHQQLPPTILSDKAATDGLTVSLMERAIQLHDDKITRMLTTQYRMNSAIMQWSSDALYDGKLTADDSVARHLLKDLHGVDETEDTCLPLLLIDTAGCGLEELDLESEVSKGNEGEADLVTVHVERLLASGVPASQVAVIAPYNLQVELLRLRLSGRHPQLEIKSVDGFQGREKEAVVISLVRSNNKGEVGFLAEDRRINVAVTRARRHVAVVCDSDTVRHHGFLRNLVEYMERNGEVRSAFQYQDEIDVSSSDVPRPDYLMFRQSKPSVRKDRGAKPKQSRPKERYHNIPDAKTREASAKKEAELTEQVQRFAEDQTRDHLAFPPTLNSHDRLVVHQVAETLGLHHSSTGDGQDRHITVSKQPIRTGVPELETNSHNAQENASASAAEERLADIHIDTVIEEMRTENPMDVIGATSLEEANVLSQDAEGNFEDDTTDTLNNGVRTDEDQNSQLDSISPKKTEPQKSNTTSGGTGEFYKCQFCKKKLPSGSVFLHEIHCEKKMEEKRRLREVSKTKKKMDKTKQRNALENTTEEDFDKLIAVAMESDNRCNFIQCKEKITLTGVHCAFCNRRYCFGHNMPEVHGCGEMARAHARKVVHREKEVRAGSGVKERKVDPTRRAHLERKLEKKRGEMEEKRTKKSSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQP4</accession>
    <name>A0A913ZQP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054012.1">
        <property type="nucleotide sequence ID" value="XM_038198084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198084.1">
        <property type="protein sequence ID" value="XP_038054012.1"/>
        <property type="gene ID" value="LOC119726427"/>
    </dbReference>
    <dbReference type="GeneID" id="119726427"/>
    <dbReference type="OrthoDB" id="7632287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="619" mass="72212" checksum="3ECEF35E9EC83099" modified="2023-02-22" version="1">MDVQPGHCWRCEKILPQRTVPCSRCPMAVYCCTQCRDRDSIRHSAVECEMFGEKKCSACGKLGKTLVCSACNSAWYCNADCQRRHFPAHKKTCREILASIKQISSNLPRLKRLGYGDFPEYFGNTMAIDFLQLDNNEWYGKSVEEKQLDRDYHVLSVGCGDLRNTIMTVASLPTEYKGKLHVTHNDLDPFMMARNVLFLFMLVHFADTDEIASSLTTIWYSLHISKRDYDLVKTSLDELIQMSAQQLHDATKGLASVLDEELGYLRQVWKGWQSLECRRDNRAAINLRQQRKNMFEKSDRMMKDDRLDYIKCLNANDRKQMEKWFEHGLFLPCEANQRDIPFDNPTLTATEASKFTAPFGSPQFQASVFLQEDDLFVYRYLMSPKRMPFTVWDCLRVKEHTSGSHSSWMVMYHKYVTNLLQKFKSFIHQGRLLIRVSLTSCLDFPRHHQSLQMPNYDRIFTSNLADFVAFAKLLQIFKPLLNSSNSYSVIVTEIMGFYNNVPEVYPWKLPEPQFHKLRRDSIRDLQTTKAAKQMLFDYHNTTSHFLRYLRAEIMAGGFDIPALQDVPSFDSVKKCQGMRMRDFRKELNKFVPFRYRLNVRSLTSPTPGCRAVEWLLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSC9</accession>
    <name>A0A913ZSC9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054673.1">
        <property type="nucleotide sequence ID" value="XM_038198745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198745.1">
        <property type="protein sequence ID" value="XP_038054673.1"/>
        <property type="gene ID" value="LOC119726895"/>
    </dbReference>
    <dbReference type="GeneID" id="119726895"/>
    <dbReference type="OrthoDB" id="422540at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="559" mass="63146" checksum="1E2B1FCA553F558C" modified="2023-02-22" version="1">MATGSGQQPVPITVVTETRNLKSQPFTHPDDQISTGNAWEEWLEGIEREFRYFKISSPIDKKDALIIYGGKEIARLEKSLPNPGDVDDVYEKLKTKLNSYYTPKKNKHHARYLFLKMRPTPQETTMAYAARLREKAIQCEFGDTRDDRILEHLIQTITSKSLIQKAINKKWSLTQMLTEAAQIEDTSLQISSMRPPDDGASNVAKVGYQQSSRQKKSTGGHYGKPKFHKSPPCAYCGLTGTHPQGKNCPAYGKKCNKCQKWNHFASVCRADRLRAESRGPPSQPVPPKYAKPKQRGNHVKKTSMEEDDQTSSDDEFFDQAVKHLKQVRRIAKTVHDDSTVTVRIDDVDVRIEPDSGAEVNIMDEHQHKALQHRSSNPQSLQASHIKLHTLQSDLPVKGEFRTIVRNDTRGAATKFVVVKGRINSPPLISKNTLIELGMMKLQPDGSLAEINDLRIPENTQTVKSISNTTTARQQTQKIVEKYKRVFQGIGLIRDVKSDTDIFAKFNMKPEAAPVAQKPRPVAYYLQKPLKEWLDQCIKEGIFEEVPPGEPVTWCSPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSJ4</accession>
    <name>A0A913ZSJ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038054597.1">
        <property type="nucleotide sequence ID" value="XM_038198669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSJ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198669.1">
        <property type="protein sequence ID" value="XP_038054597.1"/>
        <property type="gene ID" value="LOC119726807"/>
    </dbReference>
    <dbReference type="GeneID" id="119726807"/>
    <dbReference type="OMA" id="VDGVCAY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="108"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="432" mass="48908" checksum="C59843E599AA2862" modified="2023-02-22" version="1">MAHRLIVSFVVAALGASFMSTSGLIASESNKIFTLPVLVTFGLLVGLTYLVGSAYGAIFGEYYFYGDEGRDSYLIRKAPAGMTRETGIAEMKRSRKVGAIPPVYPNGWFAVLRSEELKKMETKYVHALGLHLAVFRGESGKVYITDAYCPHLGANLAIGGKVKGECIECPFHGWTYRGDDGKCVKIGYAEKVPDFVKVDTHQCHEIAGYICLWFHAEKEEPSWFPLQDVEAKMSTMGKVGFFEAYVECHVQDIIENGGDIPHLNVVHGPQIYDKHYTGTFEVHETKKHIGITASSFVRKDSKNIWSYFSPEYKKQKREIYQEQHGPGLCFVDFGKELLVIANTPVGPLRQKLTYVLYSPFTKGLKNAIVNKLRLYFSFLALQGDFVIWANKTYLSKPQYVKEDSPTVAHRRWFSQFYTEHSPRYNPPDPLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTD4</accession>
    <name>A0A913ZTD4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055018.1">
        <property type="nucleotide sequence ID" value="XM_038199090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTD4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199090.1">
        <property type="protein sequence ID" value="XP_038055018.1"/>
        <property type="gene ID" value="LOC119727224"/>
    </dbReference>
    <dbReference type="GeneID" id="119727224"/>
    <dbReference type="OMA" id="ARIMACA"/>
    <dbReference type="OrthoDB" id="5970330at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="38052" checksum="F167404F1D99D2A8" modified="2023-02-22" version="1">MTAVTLPQTTMDLGFYNASPFNVSTTPESGTNDYVTNVMRLIFVITETALLLTLNPLCLLALSHVHDTVQDTTKVFLRSMTAADLGVGIFVAFPMIPSVIYGGWPFGDALCGMQSFLLPFCVTGSLLSLLLLSVDRYISVVYALRYHSLLTLKRARIMACAAWAVVLCTVTGYGHLSGWRAKYFDYSLCCIFYIDGGGSYTYMQVTYTIILLSCLLTLAVVYTRLYLISRQHACRIHVDNQPAGQGNRLARPATKTLHTMLLIALSALFFNLLPIIFFTMIIYNNSAMLTLFLFVLPVLTNSWVNVVIYYLRNGEIRRATFNLLVSCYKCCKRCTHFNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTJ6</accession>
    <name>A0A913ZTJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038054517.1">
        <property type="nucleotide sequence ID" value="XM_038198589.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054518.1">
        <property type="nucleotide sequence ID" value="XM_038198590.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054519.1">
        <property type="nucleotide sequence ID" value="XM_038198591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054520.1">
        <property type="nucleotide sequence ID" value="XM_038198592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054521.1">
        <property type="nucleotide sequence ID" value="XM_038198593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198589.1">
        <property type="protein sequence ID" value="XP_038054517.1"/>
        <property type="gene ID" value="LOC119726750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198590.1">
        <property type="protein sequence ID" value="XP_038054518.1"/>
        <property type="gene ID" value="LOC119726750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198591.1">
        <property type="protein sequence ID" value="XP_038054519.1"/>
        <property type="gene ID" value="LOC119726750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198592.1">
        <property type="protein sequence ID" value="XP_038054520.1"/>
        <property type="gene ID" value="LOC119726750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198593.1">
        <property type="protein sequence ID" value="XP_038054521.1"/>
        <property type="gene ID" value="LOC119726750"/>
    </dbReference>
    <dbReference type="GeneID" id="119726750"/>
    <dbReference type="OMA" id="YAVEPEC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049077">
        <property type="entry name" value="MOV-10_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049075">
        <property type="entry name" value="MOV-10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21633">
        <property type="entry name" value="MOV-10_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21632">
        <property type="entry name" value="MOV-10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="526"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113814" checksum="6580D92C2DC12172" modified="2023-02-22" version="1">MKRTKGENLRIGKSFLQYLQDVYGYGNIVGRKEMGDIFRDVFKPSLGTGGSGFNLSSVLYALGTASQVELKGGKVHIQRGFHAKDQYTTLHESKEDTNASSGFLYYCPDCDVRGTSTSTIQDHVRGKKHLKQIRLKYLKDKSKELVASQRGINVHSDFEKKDGVIALVLDKNCSKEITITIKNTSATQIMFLACEMLKAQPAFCMSNTDYDAIEPGEKQKFQITVYADTVGVLQTPLLFAFNVSDEDEVFHMLRFLSIQVKSKIADDLPPTVPYQRPAKKSQRRPKGDIVDGVPLEKSGSNKLKMIKLGGYRIPDQLRDQINSKDGVKKLRKNMKKPLSWGNYASRFSSLLHQDECQMEVDIRRYDMDGVTMRKQGKLLYLKVPGLAENRPSVLQGDHLFATFTGDRSNSNPKMYKGYVHHVELEEVALGFNQEFVNRFINGTKVYIEFTVNRFTLCMQHFAIGETPKHANLQNVLFPTTSIVGDKPLLCSVPNESQFARCLYDQKLASNTEQVKAVLHILQGTSRPAPYLVFGPPGTGKTVTIVEAIKQVYKTFPGSRILVCAPSNSASDLIAKRLLSGTVTPVAKTTIFRMNARSTDWKTVDETLKEKECCNYNKMTGHNYFPPKEELLEKRILVTTLCTAGRIATAAGFPYDHFTHVFIDEAGHAVEPEAIISLANLLNPNHPHGGQVVLAGDPKQLGPIIRSPLALEHGLGLSFLERLMTGPEPYHRQDEEPHYDSRVLTKLLHNYRSHPAILKLPNQMFYANELEVHADKMARESLCKWEKLPKKNFPVIFHGVEGIDEREARSPSFFNADEIGVVVEYTQDLLAKRGGIRVKETDIGIISPYRRQVQKIKGVLKKHKMSDIKVGSVEEFQGQERLVIIVSTVRSTKPEHIQMDIDYKLGFLKNPKRLNVAVTRAKALLILVGNPYTLRKDENWNMFLEYCLENKAYTGCFFKNENDEVEDTIEKFEKLKITSELVDKPVDERLGVSAETEQHDPEWRSEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZU01</accession>
    <name>A0A913ZU01_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054924.1">
        <property type="nucleotide sequence ID" value="XM_038198996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZU01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198996.1">
        <property type="protein sequence ID" value="XP_038054924.1"/>
        <property type="gene ID" value="LOC119727136"/>
    </dbReference>
    <dbReference type="GeneID" id="119727136"/>
    <dbReference type="OMA" id="PHSANEV"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000006">
        <property type="entry name" value="High mobility group protein B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017967">
        <property type="entry name" value="HMG_boxA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00353">
        <property type="entry name" value="HMG_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="197" mass="22593" checksum="14119A484D5D8F5F" modified="2023-02-22" version="1">MGRKDPNKPKGRMSSYAFFVQFCREEHKERNPGQSVNFTQFSKKCSERWKTMDDGEKKRFLECADCDKMRYEREMARYVPPKGTKKRGRRKRKDPNAPKRNLSAFFLFSNDERSKVKAVHPDWGIGKIAQVLAEQWRNVSASQRAKYDKAAVQDKERYVKAMAEYKAKPVKKKSSSSSSSSSSSSSSSSSSSSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWS6</accession>
    <name>A0A913ZWS6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055982.1">
        <property type="nucleotide sequence ID" value="XM_038200054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200054.1">
        <property type="protein sequence ID" value="XP_038055982.1"/>
        <property type="gene ID" value="LOC119727974"/>
    </dbReference>
    <dbReference type="GeneID" id="119727974"/>
    <dbReference type="OMA" id="RIHEYIC"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586879" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18545" checksum="EC90CA0CB63B2517" modified="2023-02-22" version="1">MMLPKRLIVGLISLCLMIRCTGGNERCGASIGGACPPAWSQWGDKCYKKLSKNLPWAEAKQECIKKGSVLVMPQSQEETDFLQKNVYLWFWINCNDLQVEGTWVCQDGTTDVEYRNWRVEPAEPNNYGGGEDCAVVRRAGDWNDVECDSQIPTICQRPAPQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX58</accession>
    <name>A0A913ZX58_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056104.1">
        <property type="nucleotide sequence ID" value="XM_038200176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200176.1">
        <property type="protein sequence ID" value="XP_038056104.1"/>
        <property type="gene ID" value="LOC119728103"/>
    </dbReference>
    <dbReference type="GeneID" id="119728103"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="21794" checksum="EB41317CE35A5824" modified="2023-02-22" version="1">MGKSPWPTLKCVHLSVFLPFFVVFFCTLKTPKGQKNYYLFTDALPSACNFCLAIQILAVLIAPVIAVYRVVVNLKPDKIKVLRIIVTVGVVLFAILVLVVAAIISAGLTSLCNKLNDACPLPSKIDCVHFQKLGWDPDFDGSAFYDMTKTAESAAWVSFVLWTALAVWFSVLFLKSRRRPSLREKNAAAGSTPVDVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ58</accession>
    <name>A0A913ZZ58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056610.1">
        <property type="nucleotide sequence ID" value="XM_038200682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200682.1">
        <property type="protein sequence ID" value="XP_038056610.1"/>
        <property type="gene ID" value="LOC119728441"/>
    </dbReference>
    <dbReference type="GeneID" id="119728441"/>
    <dbReference type="OMA" id="CANSIPC"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="17"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="426" mass="46711" checksum="E1DEC074CCF35E74" modified="2023-02-22" version="1">MASADSQREFDSIGCALVLLSFTVNLLYGCVLKSLGVLLPTLTDQFTTNTWIIGIVTSLIAVASDITGLFTAPLENLFGSRRVVVVSTLMMCLGLLVVPFATSVLQLAASLVLLVGTSIGILNVLSKALLAKHFRRHLTVACGMGNIGQAMALLVFAPMMQLFLDTYGWRGATLLMAGVCFHAVPFAVLVRDADHKPNYQPLPSRNEHHEADSPGKNCPLSAFCLRLYKATNLRILLEFNFVIMFMLRFALNITFNTWMVYFVPHLVAKGFSPQVAAALCSPAAVGYLFGTVIWAPFIDRGLVKCTSGIIVSSLALAISFLVDPWVNSVLGMAVISFLLCLFLSALYTLNDVFTKELYEAERLTSAFGWIRAFGFLPRLIAGFFPGWIYETRGSYDVAFVVFGFSPVVSPLPMVFGQLWKSHKERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZT3</accession>
    <name>A0A913ZZT3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057087.1">
        <property type="nucleotide sequence ID" value="XM_038201159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057089.1">
        <property type="nucleotide sequence ID" value="XM_038201161.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057090.1">
        <property type="nucleotide sequence ID" value="XM_038201162.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201159.1">
        <property type="protein sequence ID" value="XP_038057087.1"/>
        <property type="gene ID" value="LOC119728778"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201161.1">
        <property type="protein sequence ID" value="XP_038057089.1"/>
        <property type="gene ID" value="LOC119728778"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201162.1">
        <property type="protein sequence ID" value="XP_038057090.1"/>
        <property type="gene ID" value="LOC119728778"/>
    </dbReference>
    <dbReference type="GeneID" id="119728778"/>
    <dbReference type="OMA" id="LWYPANC"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4622"/>
            <end position="4647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4668"/>
            <end position="4689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4701"/>
            <end position="4722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4729"/>
            <end position="4752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4764"/>
            <end position="4783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="4808"/>
            <end position="4829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5329"/>
            <end position="5350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5579"/>
            <end position="5602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5622"/>
            <end position="5647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5659"/>
            <end position="5679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5691"/>
            <end position="5711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5732"/>
            <end position="5750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5770"/>
            <end position="5796"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="625"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="1393"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="1972"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="4894"/>
            <end position="5124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="5839"/>
            <end position="6063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4325"/>
            <end position="4344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5170"/>
            <end position="5189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5273"/>
            <end position="5292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4335"/>
            <end position="4344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="5174"/>
            <end position="5189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="6168" mass="688256" checksum="C0480FF8114B0D23" modified="2023-02-22" version="1">[encoded data, 6168 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0E9</accession>
    <name>A0A914A0E9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056806.1">
        <property type="nucleotide sequence ID" value="XM_038200878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200878.1">
        <property type="protein sequence ID" value="XP_038056806.1"/>
        <property type="gene ID" value="LOC119728582"/>
    </dbReference>
    <dbReference type="GeneID" id="119728582"/>
    <dbReference type="CTD" id="64789"/>
    <dbReference type="OMA" id="CPDKPLG"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50374" checksum="D38998BCADE6A9AD" modified="2023-02-22" version="1">MDDAHDEFAFGSQDDALLHRALDAFDTFEATEAAVSMDVEDKEDSQESITESQNRALHEAYEAFEQTSVAGGATVNNSNPVFKGLSNEASSTSGLTISSPKTDKSERSSSLPYELNARSKESLRLGNTYLTVSNLVAQLWCEQQMVYNFWKPDLEFIVETTPAMPAKHKAAVKAVVAAASGGNKIHEKRDREVNKYVPVKAKTREDRYSIRLINIIVSLRGLLLCGEPCAREIPIFGMPLGHQFLVVGTIDELRFDSHGRFELVEFKTRGDLSRPIRRQQMQAYKMQMMLYKQMLDDLVRGRVDGREVLRSLRMDPDQVLIDELLPYVRALGDGLRTSITLGELMTIVLQQFEFLSHVEVLTLEFSGRDNSATVAKETVEFDADWLRQRLDHCRAYWTEEREVEGVDIEDTWKCRICAFYDTCQWRQKMNEICAQKNTVGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2K7</accession>
    <name>A0A914A2K7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057885.1">
        <property type="nucleotide sequence ID" value="XM_038201957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2K7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201957.1">
        <property type="protein sequence ID" value="XP_038057885.1"/>
        <property type="gene ID" value="LOC119729334"/>
    </dbReference>
    <dbReference type="GeneID" id="119729334"/>
    <dbReference type="OMA" id="PHAHDKD"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755068" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="124" mass="12769" checksum="E582B737494AAE69" modified="2023-02-22" version="1">MKMRLTLALLATFLLVEVSLACISSGKPKPDDGWGDDEGDRPRPGDGDEGDRPRPDGGDEGDEPRPDGGDGGDNPRPDGGDEGDNPRPDGGDEGDNPRPDGGDGGDRPPTDGGDEGEGNPPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A304</accession>
    <name>A0A914A304_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057761.1">
        <property type="nucleotide sequence ID" value="XM_038201833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A304"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201833.1">
        <property type="protein sequence ID" value="XP_038057761.1"/>
        <property type="gene ID" value="LOC119729245"/>
    </dbReference>
    <dbReference type="GeneID" id="119729245"/>
    <dbReference type="CTD" id="9521"/>
    <dbReference type="OMA" id="NWATGTH"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043517">
        <property type="term" value="P:positive regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10305">
        <property type="entry name" value="GST_C_AIMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053837">
        <property type="entry name" value="AIMP3/p18_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042450">
        <property type="entry name" value="EEF1E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44490:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="176" mass="19731" checksum="892C5EF7D930EBAF" modified="2023-02-22" version="1">MADIKQDLKALARFLDVKGVKVNVNSETKVPVLTLNGMTVTGLSSVANYLAKTAGRRDLIGGNDAAERAAVSQWLEYRVTEIDRCHSEKDVSTVLKELNSYLETRTFFLGERVTLPDLLIMYGVRSAVSLLTFQEKEKFMHLSRWCDNVQSIEGVLQKQQTPVFFVKNPLYAGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4D0</accession>
    <name>A0A914A4D0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058707.1">
        <property type="nucleotide sequence ID" value="XM_038202779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4D0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202779.1">
        <property type="protein sequence ID" value="XP_038058707.1"/>
        <property type="gene ID" value="LOC119729987"/>
    </dbReference>
    <dbReference type="GeneID" id="119729987"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="30576" checksum="8AC29C9B23DC804B" modified="2023-02-22" version="1">MKTCYFGPPSEPLPGEHWMQAAAREIRKRCPGTRNSTAVSQANVKIEVEIATTASAPRYADCRESHDAGVQYDAVTIYPPQYPNGLAVYCHLDWVVIQKRMDGSVNFTRSWAEYRDGFGDLTGEFWLGNEIVRQLTSEGTWELQILVGGGDHGSRILLEQFQIAGDNYILYADPSPQWPTGKSMTDVHSGQPFSTYDRDNDADGNANCAAQLKGGWWFKTCTGGVGNVDLVPTNLNGEYSYPVNYTGQDYRGMRWAGALDGQMSSSSLMIRRGSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4D8</accession>
    <name>A0A914A4D8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058693.1">
        <property type="nucleotide sequence ID" value="XM_038202765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4D8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202765.1">
        <property type="protein sequence ID" value="XP_038058693.1"/>
        <property type="gene ID" value="LOC119729975"/>
    </dbReference>
    <dbReference type="GeneID" id="119729975"/>
    <dbReference type="OMA" id="WSILCFF"/>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15909">
        <property type="entry name" value="7tmF_FZD4_9_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000016">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000020">
        <property type="entry name" value="Frizzled class receptor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037645228" evidence="18">
        <location>
            <begin position="25"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="19">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="228"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="603" mass="66503" checksum="B02D4ED91F4F76D3" modified="2023-02-22" version="1">MAGVIPQLVRILIVVTASACLASALEQRQNQCQRITIPMCVDIGYNMTRMPNFFGHDAQAEAAPRIHEFSPLVTYGCSEHLRFFLCSLYAPMCSPQVDIPIPACRPMCETVRDKCEPVMQSFGISWPDALKCDTLPRGVERDDLCMVAPNMSGGNEGEAGATVDPDGGFHPGGGGGIPKPTPPSSKPNGTDNRRCPNHERFVMLPQTKSCVPRCDRDVYFQQSDKKFAELWMGIWSILCFVGTAVTVLTFLIDRGRFRYPERPIIFLSMCYNMYSVSYIIRLFAGPRAIACGHTAGDEYYLIQEGLESTGCTVVFLIQYYFYMASSIWWVILTLTWFLAAGMKWGYEAIAAYSSYYHLAAWALPALKTIIVLTLRRMDGDELTGMCFVGNQDPVALAGFVLAPLFVYFAVGTLFILAGFFYMFRIRKVMKSGGTNIDKLEKLMVRIGVFSVLYTVPATSVIACYFYQRANLEVWEVIATHANPCLPNGDCNMAFSIPSVPVLLVKTFMLLVVGITSGMWIWSTKTVQSWEAFLGRIFRTNGHRKQAASLPSYAQTAGAAANPAPGQANPAPGLGVKYTRTPNPANKAHSIAYTNFEGGGTAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4N6</accession>
    <name>A0A914A4N6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exosome complex component CSL4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058346.1">
        <property type="nucleotide sequence ID" value="XM_038202418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4N6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202418.1">
        <property type="protein sequence ID" value="XP_038058346.1"/>
        <property type="gene ID" value="LOC119729719"/>
    </dbReference>
    <dbReference type="GeneID" id="119729719"/>
    <dbReference type="CTD" id="51013"/>
    <dbReference type="OMA" id="PMVPVGW"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000024">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21832" checksum="C8BE9F9BAF012BEC" modified="2023-02-22" version="1">MAASTICIPGQRLGSTEEFQAGKGTYTRQGYVYSSLAGFRHESKQGEDLPELQVLLEDQQTVVPEVGSVVTVKMTSVNPRFCRCAILSVEGTPLTQSFRGMIRREDIRATEKDKVEVYKSYRPGDVVLARILSLGDAQWYLLSTAENELGVVLAQSEAGVNMVPISWCEMVCPKTHSKEFRKVARVQPQYLIQPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7F7</accession>
    <name>A0A914A7F7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059384.1">
        <property type="nucleotide sequence ID" value="XM_038203456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7F7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203456.1">
        <property type="protein sequence ID" value="XP_038059384.1"/>
        <property type="gene ID" value="LOC119730481"/>
    </dbReference>
    <dbReference type="GeneID" id="119730481"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037529470" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="18169" checksum="EE5482940DE85606" modified="2023-02-22" version="1">MSLRQACSVLVGITVIVLTSPLTPLASSEVCLTSLVSCQPGWQPWGRGCYNVTTAKLQYSEAVAHCVNRGARMAAARSHEEKEFIQALLVRKVPGVKASWVNCRSTPREGGAHRFECDGDEVSGLGEYYRNWADGEPNGNAADLALGPRRVPELLKDRMVPSSVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9F8</accession>
    <name>A0A914A9F8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase I subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Twist neighbor protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060388.1">
        <property type="nucleotide sequence ID" value="XM_038204460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9F8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204460.1">
        <property type="protein sequence ID" value="XP_038060388.1"/>
        <property type="gene ID" value="LOC119731310"/>
    </dbReference>
    <dbReference type="GeneID" id="119731310"/>
    <dbReference type="OMA" id="CLVVETH"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="581" mass="63141" checksum="9C8CEEB8B0A8FE21" modified="2023-02-22" version="1">MNALEVFGSFESAAELDKEPHTGCTLVSAERHIALSPKYIGRLRTGVGEILDAELGRFSESLRGVLLAYGNVKLLQSSGVIVDDSPFIHFDVKFDAVVFNPKIGSLLKCVVIEQASDHVGCLVHDWFNVSLLASRKELSGQKLPKLEPGYVVLVQVERLRSLNRMLAIEARAPDDGSDLILEAMSLQSKDTDSESNVDSVLQSSLSDTPDVAGKSSGTTGNEASGEKKKKKRVKVKLEQADSLQSSVSDTTDVTPMSTVTAGTEASGKKKKKKHAKVELPEVDSLQPSVSDSVDGSGVLTIPFGGEAKSEKKKKRKHENVKQELDVDSLQPSLSDLQDGSGSSRTAGEEARGGKKKKKHSEVKQEWDVDSLQPSLCLKSSTGETQTGVETSKHKKSKKRKQLETTDETSGIRTQNNAAELTTGEQTSPKKKKKKKHSKNEAAEPGPKSLTNHSGHQITQITTGEETSSTKKNKKKNSETRTGVDCYQPSFIPNGPTAIVSEKEVEMKLQESHDEDVVSNLLPLFNEQFTKLKKHKDREIHTAVDSSLKPLSPDSSSTVQTVKKVKKHKKKVQSENADGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABW7</accession>
    <name>A0A914ABW7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061410.1">
        <property type="nucleotide sequence ID" value="XM_038205482.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205482.1">
        <property type="protein sequence ID" value="XP_038061410.1"/>
        <property type="gene ID" value="LOC119732094"/>
    </dbReference>
    <dbReference type="GeneID" id="119732094"/>
    <dbReference type="OMA" id="DHSAKEL"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="13">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="906"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1604" mass="184644" checksum="D2CDF140FA5EFFAE" modified="2023-02-22" version="1">MEPYERIQLERLLKEFDLYLHNGTAISKPAAVAVTSFDGDVSSPCPVEAEYSEEAARYEQVREMAGTGNGRRLDDLLGEFKEEGWLRDWRSEENLTLYADAITDGYIDIINALLKYDIPLGDALIRAIDVECGVATKSICCYIQEREDILESILNGHSDNDDFHPVITPLVLAAQKNNFEAVKVLLELGSSITEPSLSYGADVTLTQALSTLHIYRAISQPAYILATQTDIFGHAFQMSAKLKTLSNTWEDFGPEYVKMARGLEVFAGGLLGESASTEEILALFRYHDTDKYRDVDGKQHPLAKLFEAIDYEQKEFIAHPHSQKAIIVQFYRNLLDWNERGIWYQVLLTFLVVLGYPIICLLYLFVPVRRVVTFARLPYVMMMMKAGSGFTFLVFIVVINALDRHSYPRSVEVLYWFILIWIVGLAWSHFKIFRRYGRNKYLSDNMNLHEIVIIALCVVVFCLHWTGRVETSPDVIKLDKTLNNTLPNLRNQVMEATDSLRGRLNDTTLAGVNDDIMEVLSNDCRLRNSTIQGLDILPLSLQETIEHDQYEPLVVARTLFGVAITVSVLRLLNLLLVSDTVGHLRISLGEMMGDILKFCGIFLIIWFAFAIGLFQNFYSAGQSVMRACIQQGEEPGSCQLLVGFSTFFVSVKDLYWALYGFVGPRGLELTGKHSVAETVGTFLFVCYLIFAVVVLLNALIGMLSNTYNLTEENADTEWKFHRAAVWASYLRPVGTLPPPFNLIPSVKTLCHLFKYVCKCSTCGRRRDSGWPFSLQKRMHQDSELQDYKRVLKLVRSRYIQAHLSVESQNSEGVRPRDLQTLRNDILAFKFGVQDRLASIIRTIGISNDKSNHINTRLYDLDPVKERAMNLVDESSMLTDTLGILHQQTDDLHKEQTDELNHREKHSSELEQIVAALRAENEILKRDASVKAMQAMIRELEQDKTALADKLQSLGKDKDDLLQENDQLKRYLSSKEMRSDQQEKELKEIIQGLQQDKAALSDTLQRRKKDHAELLQQFDKLKSDHSEKEEELQEVIRRLGEERDSLNKILQGLEADKADLLKQIDELKRDHSAKEMMREKTEAELRDIIQDLKRDKTVVKDTLQGVSDDKDDIVRQMDELKTEHLAKEMSRDQHEDELLDIIHGLEQDKTDLTETLQRLKEDQAELLREIDELGKDHSAKEKARDQQEEELQDVIRGIRVERDSLITTLQGLEEDKADLLKQIEELKRDHSAKELVRELKEADLQDIIQDLQRDKTIVADTLQGVSDDKEEILRKMDELKNEHMAKEMTRDQKEAELQDVIKGFEEDKKVLTDTLQVLEEDQAELLHQIDELERDHASKEFMRDKQEEELKDVLEGLRQDKNVLRDTLQGLEEDKTELLRELNELKKDHSAKELTRNQQKKELKDAIRELQQAKADLMGKIQGLKEDKADLSQQIGELKRDHLAKEARRDKQEAELQDHIRGFRQDRLVLKDTMRGLMEEKADFKQEIDELKQEHLAKESTRDQQEASLQGVIGDLRQDNTDLTNRLRELNDDKANLLQQLDQLKKEYSSKDITRDKQEAQLQDLIQGLRKDRSALNEDKVQLIRQVGELSEELRKLKRTQPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACI6</accession>
    <name>A0A914ACI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061635.1">
        <property type="nucleotide sequence ID" value="XM_038205707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205707.1">
        <property type="protein sequence ID" value="XP_038061635.1"/>
        <property type="gene ID" value="LOC119732256"/>
    </dbReference>
    <dbReference type="GeneID" id="119732256"/>
    <dbReference type="OMA" id="ITTWANG"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="189" mass="21380" checksum="05912186AA444054" modified="2023-02-22" version="1">MEPQLVRLSKTVTIFVTFFGLIKTLSAACLPNSTQFESSCYSFLNITTWANGQKWCQEIGTMHMVIESAEENAFIIQEMRLRDMAHAWIGCSDEQTEGAWVCHFADGVTRAMSYADWRSDQPNNWKNQDCASVRSDNGKWMDDFCHHHERFYVVCETNSTKVEIPPAVVSSSAGTVTCYIMGADGRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACN3</accession>
    <name>A0A914ACN3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061685.1">
        <property type="nucleotide sequence ID" value="XM_038205757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205757.1">
        <property type="protein sequence ID" value="XP_038061685.1"/>
        <property type="gene ID" value="LOC119732297"/>
    </dbReference>
    <dbReference type="GeneID" id="119732297"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673222" description="Sema domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="4">
        <location>
            <begin position="24"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="518" mass="57023" checksum="E43B0C037DA94DEB" modified="2023-02-22" version="1">MESCRRHTTLLWAVCLILSIICVNVRIASAERLGDLSDYELASFDNPDILGENERRASKFNHFTLSDHGDVYVGAVNWLYWLNGSLGEIQNVTTCNASKPDSMPCHLTNNYNKILVVDSTRPDSLITCGGVYDGICQSRQLHNISNMTMESVTYVAGYEDASTVSVIAPGRDGNQMLYVAVTFTGENKAPTNFPAVARRTLANPLLSATNLFNTVPFDLPALQMRFVIKYFLTFAYRGFTYFVTSQKEDLTDSAQFVSKMSRVCQTGPNLDAYTEITLQCSGSGDSVYSLVQAAHFGPAGPDLAASLGLHADEQVLYAVFARNQGAPGTSDVPIDHSALCVYRMTDILAAFKEAVRGCIQPPMPQPEPYKVDYLAGSFCSSFSIVQESTIFVYVTEGRARFYPFLCNVCSSGTEEACTVAETSQENKVRRSTSSTSSTTSTSSSPKSTGAKKNEDAVRCSSKKEAETVPSAHRSKEVESHVAFPKPASPYIAARKRAQRRGVTARRIRKRRRRRKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACX4</accession>
    <name>A0A914ACX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061687.1">
        <property type="nucleotide sequence ID" value="XM_038205759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205759.1">
        <property type="protein sequence ID" value="XP_038061687.1"/>
        <property type="gene ID" value="LOC119732299"/>
    </dbReference>
    <dbReference type="GeneID" id="119732299"/>
    <dbReference type="OMA" id="MAICITS"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000131">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000868">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036942254" description="Sema domain-containing protein" evidence="15">
        <location>
            <begin position="34"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1286"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="16">
        <location>
            <begin position="27"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1321"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146886" checksum="0AA07A0B7450A143" modified="2023-02-22" version="1">MSTMESCRRHTTLLWAVCLILSIICVNVRIGSAEWLGDLSDYELTSFDNPDILGENERRASKFNHFTLSDHGDVHVGAVNWLYRLNGSLGEIQNVTTCDDSRPDSVMPCHLTNNYNKILVVDSTRPSSLITCGGVYDGICQLRQLEDIHDVVMESVPYVAGFEDASTVSVIAQGIGGNQTLYVGVTYTGQNLESGGVFPAITRRSLEMANFLSAVQNDNSIVFTAAAGINNLLIKYVLAFGYKGFTYFVTSQKEDLTNSAQFVSKMSRVCQGGPNLDAYTEITLQCSGSDGSVYSLVQAAHFGPAGPDLAASWGLTADEQVLYAVFAKNQGAPGTSDVPIDHSALCVYRMTDIWAAFREAVRGCIQNGNSFSVDYLEGSFCSSFGIPILDRYFCIPVTNDQNQLQLFQYAKGIDPVPSTAVLELPGTLMSSIITSIEVNHTVAFIGTSSGDLLKVYMESNIAARLSERVSLDTSPVLTDIKINETSGVIYVLTEQKLVKMQPENCDRYTTCEACIGTNAGNDGDPYCGWCTLERRCTRYHDCPLQDVSTRWLAYNDSQCIEISQVLPHNSLPITLTDQQIMLTVQQLPDLLDGEHYVCRFGDQFSSQATNYNGDSFDCRTPPANNIPAIPSGEDHVTVTLSVMSSETSVDFVHIDFGFYECDTHKSCVTCVGSRWACNWCLFENTCTHDNSTCSNPNEIIMTGQYSRGTAMQGPNSCQPQLQPQRGEVLVPSDINRQIVVAVDNPPDTAESFQCSLDVEGSTQSVAATRVHSSLICGMKAYTFTAAEQELNASLTLQWTDSNNVMHTVDDRYNFTVTLYKCEVLRPDCSRCISNETTRAELGCMWCGDTCGVIDSTVCMTADEKVTRNNTINCPDPLLKQVYPLFGPTEGNTLLTVSGTDIGLRYSDILEVKVGGQDCALDDYQYRTGSSVSCRTLGETATRRRRDVTPPSLQMTVTGRDGSMQASQGNVTFEYKNPMLDDINPKMGPQSGGTRLTISGQSLDAWRNIEVFIDDIPCVVDRARVTDDSITCITSRTDSLGSWIVNVSFDGVERFSMANYTYTVDPDVEEINPSTSVLAGGRELTVNGSGFSIIQQPQIVIIYGDNEQEFVGNCSVTSDDKMICTSPEINIPNLVLDADTSVNVTTGFIMDAVEALRTWCSVDQNDGCTPLEYFQNPEYYPFNDPAYGNVDGIEQQAGPDLTIKGVRLNLAITNEEVTVHIGKSLCTAVTVGAGALSCRLPEEGPAAGDYLGMNTTKGLPVVWVIHGNTLSFNIGYFQYAYNGEPSLLIPLVCSVSACVLLLVVLLAAVLYKKHKRSQKVADLPIEESGNQQKQVADDMKTDSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFQ6</accession>
    <name>A0A914AFQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062805.1">
        <property type="nucleotide sequence ID" value="XM_038206877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206877.1">
        <property type="protein sequence ID" value="XP_038062805.1"/>
        <property type="gene ID" value="LOC119733279"/>
    </dbReference>
    <dbReference type="GeneID" id="119733279"/>
    <dbReference type="CTD" id="9868"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="66418at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63158" checksum="07DB702DA1B1776E" modified="2023-02-22" version="1">MADSGEASADVGSSLPKSWKIALAIGAPIAIGVAVGAFYYSRRRSDLSSGEKGGKTQTKGKAKQGEPTAHAAAADERTPEEKAQGSKNKGNKYFKAGRYEQAIACYNEAIELVPLDKTKDLSTFYQNRAAAHEQLKNYAQVVTDCTKALELNARYVKALFRRAKAFENMNQKMACLEDTTAVCILENFSHNQSMLLADKMLKELGKEKAQQRYKERVPSLPSGQFIRSYFSSFSDDGISRSSNDYNDEGAGDVGNTGYRKAHRLFTNGDYNGVIEACDEEINTDGDKLAEALLMRATFYLLMGQAAEARPDLDRLIGMDESSKKLRANALIKRGSMHMQEGNSSDAMNDFATAVRIDPDNADIYHHRGQLNLLLDRIDDAAQDFEKCNKLNSNFALAHAQYSYAKYRLALVHQSPMQLHTAMQELENSTKKFPTCAEAFALYAQAQSDQGQFHVADEYFQKAIALEPDNPTAYVHRGLLHLSWKKDADGAIAMIQKALEIDSKCDFAYETLGTIEVQRGNMSAAKSYFEKAIDLARTEMEMSHLFSLSVAAEAQRNVTTKYNITPPSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGL5</accession>
    <name>A0A914AGL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062852.1">
        <property type="nucleotide sequence ID" value="XM_038206924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206924.1">
        <property type="protein sequence ID" value="XP_038062852.1"/>
        <property type="gene ID" value="LOC119733340"/>
    </dbReference>
    <dbReference type="GeneID" id="119733340"/>
    <dbReference type="OrthoDB" id="5959240at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548326" description="ZP domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="568"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="908" mass="100338" checksum="9DB138FFC1C0836B" modified="2023-02-22" version="1">MGGLLQALLVVVFLQGCHCGEVRSSHVRDLTLSVKAAENESQDTVDVSPGQHDEQPAIKSLQCSDSASPPVIVETWPDPAVTRIPAFADWTFHFKFNQNVNRAPRPAFVKVYYRVGTWVFSIDASAGDNVHFPAPDTMQVVVPANLKALLAGGQVFHVLLDEGVVTGPGPCYVPSAAVTDPNFYKVLYSGLPDRYHDTPYYTTPAPPSSCSDTERPTVIQSWPADGFYSSLSIAKLTLKYDREVTVAQSLTGVYIYRRHAWQSAQNCKIVQTAVDTIETDCYSSMNLDVYDLDGNGVFTIIMAEDVVTGPAPCNASSGWLAITLYTGSPPATDGAPTYAYITEQFGDWTTRDNPGFQPTTEYWPTTQEVTESPYTEPATTPWLDCASMASPVVIEAWTNATVNLPNYSLIWNFRFDQHITKATGSSWVYANFYESSGQFRLGIPTWHTYHVRFPAPDTLQVLVHGPSYLPIGQEYYVLLDEGAVNGAAPCYIPSAAVTDIYLCRAVYGVAPNATDEVPIYTTQVLEDWTTSLESDNPTKQPTEFTTEEIGWSTHQPRMTQPPLLPSMDCSESGMTVFIPRSVISDALSSHLHFLDPSCVGSHHNATHVKIATTYDRCGTFMEVHGDSVIFFNVIHDEAVPVEPGSVITRDRDIEIPVQCIMDLEGFAEISFRPDTSKITFREDGFGSFNFSLRLYHDNDYTTPYQPADYPVHVAMGNKLYFEARTWSEPGLELFVQTCRATPTSNSDDFHRYTFIQDGCIEDNTVMFHLSDDPDIERFEIDAFAFVDTLPQPVVYVHCDMVLCNSTDASSHCAIGCPTRSMNLLPGVHRRHARSSSGSHAYAITQGPISVMDDGGKEGSELSSVQLPILLTTVCLLVGCVLVLGTLIVVMRKRTQRLQLYSPLATEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHL7</accession>
    <name>A0A914AHL7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063217.1">
        <property type="nucleotide sequence ID" value="XM_038207289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207289.1">
        <property type="protein sequence ID" value="XP_038063217.1"/>
        <property type="gene ID" value="LOC119733928"/>
    </dbReference>
    <dbReference type="GeneID" id="119733928"/>
    <dbReference type="OMA" id="MFTANTD"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037135362" description="F5/8 type C domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="69"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="24587" checksum="F6EC165A88EEAAA8" modified="2023-02-22" version="1">MDGAVALVLMLSAMAVILIGVESQQRVCYSGPPPEPDPDNPDDWMKQVMQEIRKRCPGRRQPTPAAAECSSPKPLGMENGTIHDDRITASSRNRCCPVSLARLNSNAGWVADHLSRDANPWIEVNLVEPTVVSGVITQGKNFFDIYVKKYKVAYKKQPSSDYEHVTDGNGNIKVFIGNTDYYTPVTNLFAESVVATVVRIEPIEWHQMTALRLELLGCRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AID6</accession>
    <name>A0A914AID6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063159.1">
        <property type="nucleotide sequence ID" value="XM_038207231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AID6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207231.1">
        <property type="protein sequence ID" value="XP_038063159.1"/>
        <property type="gene ID" value="LOC119733865"/>
    </dbReference>
    <dbReference type="GeneID" id="119733865"/>
    <dbReference type="OrthoDB" id="6149269at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="309" mass="34877" checksum="8D9C665C73CAEEA1" modified="2023-02-22" version="1">MFPGKVGYVRKVMMVQSELNAPLSAEEATGPEGDSDLPGVLQSPDVRSQLTAAPMAPRILDISKLSSPSMASVGAGGDDVAEEAGSHQDLESSDVALQGPSSRLETPKTPMWNMFTTPQTWPQYSDRVVSALKSGNIMADWDALIAETAYFILKHHDMKAPSEYDDVGRLVSERWPCILFEEHGKKPWNHFVKRLSQKMRNIRWTRKRKMEQTKQPATTKRTAVAAADYSFEADGDSPEELLKADLLSELQKDKPDKAKIGHLQKLTFNLRKREKPTFHDYPFLLEEKFIKREFFLRQPEVSEASLQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJZ6</accession>
    <name>A0A914AJZ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064305.1">
        <property type="nucleotide sequence ID" value="XM_038208377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208377.1">
        <property type="protein sequence ID" value="XP_038064305.1"/>
        <property type="gene ID" value="LOC119734808"/>
    </dbReference>
    <dbReference type="GeneID" id="119734808"/>
    <dbReference type="OMA" id="CRIWRIV"/>
    <dbReference type="OrthoDB" id="5859976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="36751" checksum="C2E26539C28321E6" modified="2023-02-22" version="1">MYAVFEALFSVVGSLGFIGNVLVCVTICYTKALHSITNLFILNLAVADALASVAHIAVPFAFHHFDVELLSLNKDNVTTTCTPELVFWYDVIWVVHYLGAAFVAHSVLGLTLTTYERFIGIVRPLHYTSYFSQRKIVVMLLAMWVTPLVVELPRFVYTIIAYWHRNCVSAKDSDEYYYTFSILSMVLLAGPTGAMVWMYVQILKNLKQGAKNLQQLGVKGSAKELLEAHKKVTVAMAVITAAFFILVLPAKIFQIVIAVNSEVQSLALLQTSILLVVLNSAINPVLYGFKYKQLRESFVSMVMGKCRKLKRQNHVEQAPRVEMVQTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK39</accession>
    <name>A0A914AK39_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063931.1">
        <property type="nucleotide sequence ID" value="XM_038208003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK39"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208003.1">
        <property type="protein sequence ID" value="XP_038063931.1"/>
        <property type="gene ID" value="LOC119734477"/>
    </dbReference>
    <dbReference type="GeneID" id="119734477"/>
    <dbReference type="OMA" id="TIEAPTC"/>
    <dbReference type="OrthoDB" id="10072175at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="616" mass="67906" checksum="AC6573752116693B" modified="2023-02-22" version="1">MMDAVQEEVASPSCSDENGGGTEDEASPANEDADETDSDTPKEEEENGAVCSSLKLDHRMQRTLFEFEDADEAEQAAADPQSLSQNLTKFKDDLCGWVPDTSVQYRRTAAGKQPPKAGRTGSKSDGASASSRRFLNYRNKYGHTHQHTANNVEYEFKHFGNYKKYSEQYRRFHTCGGPLQKLTQSALGGRSRTIYYAGDATAEAGVEVGTCTSNTRSNSQEPRIGQVMAGQTLRRPRVSEKPSSTTQPILSYSDISVNSPRYNLLSEPTHHRKARALQYPSSMEWTHPQTETGLGYGSQQRTGTNGRQTQGAQPQGQWNVAMNDQTLTVYTSKPPGSLPAPTRPATPPKPHLPFFPSQQPLRQLTKTRSSLTPPGLNPSNELLPSGYSLDRSLGTPAGYSTGISRNPAPHRDFYSQLMHAAHCLSLAAKSPKDFNFELPRWPTCTSHTEISTGTQLHQTSHPEKPPTTSSTSSSTSSSNANMQVQMMGRGVSTSPTPTNQTLRSTSRPCKQQHRQQQDRQKIRKSASMYSMENPTSATETHYITIEAPTCSPFDTRSAKQVRRPRDTTEEVGVSKAASYRVTLKEKSVVPEIKEKTSVEMVADANRPLAVCEVTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALV7</accession>
    <name>A0A914ALV7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065005.1">
        <property type="nucleotide sequence ID" value="XM_038209077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209077.1">
        <property type="protein sequence ID" value="XP_038065005.1"/>
        <property type="gene ID" value="LOC119735380"/>
    </dbReference>
    <dbReference type="GeneID" id="119735380"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="16"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="47669" checksum="01D2656D1DEFB816" modified="2023-02-22" version="1">MGETEARGRSHQGWFAVLCLFASYFLWVLLIKGLGVMLPTLQEQFAAQTWLVGWMVSIITAVICVTGLLARPLEVIFGTRTVVTVSGFVLGVSIIIASITTSIVALTVTLALAAGPSLSVVHILTRSEIGRRFTTNYATAVGIGTSGAAIGMVTAGPFTQLLLDTYGWRGALLILGGLTLHLGVCGALLRPLSTETQMNGNYRSVSPDADGETQVSSSDVPGTDSSKQTSRLGAFKDALSAQLKHFGFSVCFQVSFWITTVVFTCSRFVSDHWLIYYVSQAEAKGFSPYEAVTFTTAAGVGNIVFKAVFGPVVDRGLLRMRPAMVLMITLGSLSLLITPWVNSYWLMMIDAVVYFGGAGVLVALNDLYTRELLGTDLLACAFAWMELVTAMLSFSLGFLPGWMYDQTGSFDLAFLILGCISFLPLVALIAEWVLGRCKSQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AME2</accession>
    <name>A0A914AME2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064907.1">
        <property type="nucleotide sequence ID" value="XM_038208979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AME2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208979.1">
        <property type="protein sequence ID" value="XP_038064907.1"/>
        <property type="gene ID" value="LOC119735280"/>
    </dbReference>
    <dbReference type="GeneID" id="119735280"/>
    <dbReference type="OMA" id="LAGQCEP"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="186" mass="21113" checksum="769EB0BFA055EA32" modified="2023-02-22" version="1">MFLLAGQCEPTPTVQQKRLKLLYYTDSDDGSHHLTNTKIAAALVKKRHDVTFLLSDSCTKWRNASGADMFRFAVHRSLYTAEERERNARGMSRHALRGKLRGAVNAMKFLLRLRYSAEYQGHRELFNFLWSECDSLLGDNATIHSLREESFDLLIGDDLSDCQRLLAEMLGIKFVLVSGTGITPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMJ3</accession>
    <name>A0A914AMJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038064957.1">
        <property type="nucleotide sequence ID" value="XM_038209029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209029.1">
        <property type="protein sequence ID" value="XP_038064957.1"/>
        <property type="gene ID" value="LOC119735333"/>
    </dbReference>
    <dbReference type="GeneID" id="119735333"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037022265" description="receptor protein-tyrosine kinase" evidence="20">
        <location>
            <begin position="30"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="258"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="540"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="547"/>
            <end position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="847" mass="95431" checksum="E6AF3720AE75D3BB" modified="2023-02-22" version="1">MATFRMSCVSIQRFIVALLFAFQVPPIMSVASWVNVGTTTSMQCASTSPNSLRLLQWRNSSFDVTDFRMSDILIDFTPTPTHNVLNRDPAHYTFDKDDTTYPLTINTVTFDDDEARYWCVVNSAIDGERHVYFDVIVVVPADVRDRLYVVQSGSNITLQCAPTSPNSLRLLQWRKSGFDVTDYRMSDILIDFTPTPTHNVLNRDPAHYTFSKDDPSYPLTINTVTLDDEARYWCVVNSVTDGEREGSFDVRVRVTPLPPENVSVVQGSVTATSVTITWRPGIDVGEHKWFYFNIREVDTTTGFDPNTRVRISDGVVMHVIDGLSPYTKYEIEVYAENAYDVSQNVRRTVTTLPDTPETLDISVTTNQENGIISVDGIPQDGDTSSCLRLETRLTNQDDWFYYGECLETNTDLALREARSRYCYGDLCSQATTAKTVVGQSSNAGLIAGIVILAIVSIISITLNAAIIMYTKRRGLKRGNCNCFPRKFKPEDKRGVINEAVEYQDLDVPLQIMAVGGSSNPAASTYASISETLAEFSREKLTIVRELGQGAFGRVLLGKANGIVQQGTVTQVAVKTVRDDADVTQRRDLLRELDFMKKLLSHSNVVKLFGFCIDRDPIYIIMEYMSKGQLKELLTSSRGKGKLQVYSNLHGRSKSLTSRDLIKFAADVADGMAFLASQQCIHRDLAARNVLVGENMICKVSDFGLARDVKNMRVYQRKSEARLPIRWMALESVVDDVYTAESDVWSYGILLWEIVTLGARPYPTMSFKTMISKLQEGYRMPRPEHCQDELYQMMLACWEEEPTARPSFTEIGRKLEKLLEGAHDYIALSDYQEFDYEVTIPDSPDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AML8</accession>
    <name>A0A914AML8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064838.1">
        <property type="nucleotide sequence ID" value="XM_038208910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AML8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208910.1">
        <property type="protein sequence ID" value="XP_038064838.1"/>
        <property type="gene ID" value="LOC119735205"/>
    </dbReference>
    <dbReference type="GeneID" id="119735205"/>
    <dbReference type="OMA" id="FRENEYA"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="76026" checksum="F0F222453FC293C7" modified="2023-02-22" version="1">MSVSNASRSSKAGTSSSISSARLKAAATLAGLQAEAASRIALKAIEEEEFRLVQRKRDCELQLEIAKAEAEQRALGDIEQSSHEDEPKPSLVGSTAAEKVDQWLTGNPQPSAPVQPSSPMAAIPLQREMIDTLLLPKCELVKFNGDPLEYWIFISSFDAAVGNTSVGASAKLNRLFQYCCGEALAVIRCCAVMQPDEGYTRARALLRERFGNDYRISETWVSKLTEGPRILPGDCRGIQKLADDLRSCTLTLTAMKKLGEVDTKRSLSLIVKRLPQFVQGKWRSKAVGILDKTGHYPDVAELVKFISKVAREANDPVYGLENRHSDEKSPKKKGSNYNIQATSEVDHRSRVGTDSPKRQCGKNELVKRTACPLCSGEHALAACDNFGKMSPTDRVKVASENKLCFNCLSSRHFSRQCKAAPCGFQGCRGKHSRLLHGVFQRANSEDGGAPKESPDDQKVGATSLACGSSQEHSKIALPVVAVMVRGAGSGEWLKTNALLDPGSNRSFCTMELVKMLGVKGTPQSLSLDTLNENAQVQTVVLSLDVSGTVGKAHTRKSFCIPEIHALKEFPTLRDSCATFEDVKKFEHLRDISVPCVAKDGVAILIGQDVPQALVPLEVRRGAEGEPYAVRTCLGWTVNGPLASGSPAAAVSNFVQGGLEAQVERFWKLDTADLSDDRTMSLDDKKAVKTWNDSVLSMATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMZ3</accession>
    <name>A0A914AMZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064973.1">
        <property type="nucleotide sequence ID" value="XM_038209045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209045.1">
        <property type="protein sequence ID" value="XP_038064973.1"/>
        <property type="gene ID" value="LOC119735349"/>
    </dbReference>
    <dbReference type="GeneID" id="119735349"/>
    <dbReference type="OMA" id="EXHFRES"/>
    <dbReference type="OrthoDB" id="6241411at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17237" checksum="2885823DBFEC526A" modified="2023-02-22" version="1">MELYATENTLSEEALNGIVSLPVMEVLDKDPTQEELSKAIDRLACGKAQGADGITPDIIQLGKPTLLPYLHDLLCLCWNKGAVSQDMCDAKIVTLYKNKGDRSDCYNYRGISLLNTVGKVLGSVALIRLQLLAEHVYPESQCGFRAARSTVDMIFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APP4</accession>
    <name>A0A914APP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038065722.1">
        <property type="nucleotide sequence ID" value="XM_038209794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209794.1">
        <property type="protein sequence ID" value="XP_038065722.1"/>
        <property type="gene ID" value="LOC119735856"/>
    </dbReference>
    <dbReference type="GeneID" id="119735856"/>
    <dbReference type="OrthoDB" id="2430314at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="180" mass="20491" checksum="855CBF15827D9A96" modified="2023-02-22" version="1">MERHWEKRNMYVNRKGYHSINVQANYKLTSVVARWPGSTHDSAIIHGSILGERFTNGHAMFTTVGDKSLLKADIAPFILLLLRCNNCALLYCRLTGVLIGDKGYALRPWLMTPILKLATNAERRYNRSHRKSRVVLEQTFGQLKEWLLRGHVSLKKVIDSDMLGTIPGLLDDNTSSHTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ75</accession>
    <name>A0A914AQ75_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065589.1">
        <property type="nucleotide sequence ID" value="XM_038209661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQ75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209661.1">
        <property type="protein sequence ID" value="XP_038065589.1"/>
        <property type="gene ID" value="LOC119735745"/>
    </dbReference>
    <dbReference type="GeneID" id="119735745"/>
    <dbReference type="OMA" id="MYIDVET"/>
    <dbReference type="OrthoDB" id="10072610at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037103316" evidence="3">
        <location>
            <begin position="27"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="807" mass="86773" checksum="2801053F953A3453" modified="2023-02-22" version="1">MDDLRWRSGWILLVVLVHNGVNLAECRPVESKEGDSFASAGLLTKDTKLTHNLVLGLLVTAATLISLMIALMLCACDSMPERNDQIEVATDNGEVAVVDDGVPASPSPDALTAPVPDPALAVPADSAPKMRTASASSNNPGHSDDPLIRCSTIDRRLPELPPTPMPPVTPTNEDEEDDYNRTYDVIGETKTNAGATKDDKKQESFPEDEVEDEQYASVSDSAAGKQNRGVKAEPTADADYNSISVTNSGVGNAEEGDEPYAVVVVPGAEAKDVENANYASVGTDKEEKEGYSRLRSIQKRTREESPEGGEKNGYARLRDIAVDGSTASGAVGGAMGGAMGGAVVKEEDEEVPPVPYKPPDLQNEDEENSPIPRTPSVGTAAGATVNGITVNIDGNAPATKKKEPPYTQVSARESLEVVRARQQAEQSARQAAHYQTIEEDQNLDADHDGIYEPVDDQQLDGQMVLSPPPLPGDRQGTTNGPSASNNWQMTRAPRVYEEITDETRPRPPNMLAAAANAQAENDDDIEPYAVTEKRPNPADIPTYSVVDKKSKVHYAKVNKAATNPDQANNNARTEVRSPDPGSSSPVPTDEAGLPLYAVVEKKGRSKESETKEDAAEYAWDDLTASTKPQEDAYQAVEDNYQTVGDMPGTNGDLSAAAVAGGMVHVSQRDPPNDLWTKKEHMYIDVETNQPSTPPAGAEQRSPAGPRTNHSYESVEVVPKPANKKEKQKQAKKEAKQAKKEAKRERKHSKGSKGAKEKDKEGEAKGAAGEDTVWQRQESPEANGNSNNNTDPSDDYENVAFPLQETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQM1</accession>
    <name>A0A914AQM1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038065943.1">
        <property type="nucleotide sequence ID" value="XM_038210015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210015.1">
        <property type="protein sequence ID" value="XP_038065943.1"/>
        <property type="gene ID" value="LOC119736028"/>
    </dbReference>
    <dbReference type="GeneID" id="119736028"/>
    <dbReference type="OMA" id="WISGNDE"/>
    <dbReference type="OrthoDB" id="538607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="284"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="398"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="681"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="824"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="688"/>
            <end position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 22">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="988" mass="108026" checksum="9429D320C9BB70BF" modified="2023-02-22" version="1">MTEDALTTLTCTADMGYPDDWTLVWSNGGSPGPSTSSSASGDRYSFTSMLDYTQRRQDNGNIITCVAQRDSGTRSSEGTLPIDVQFCAEAVSVSCPSSTASGSIVQLSCNSGSSNPATSLVWSKNNVDQSNPSQPVFTDGDYDGRETTLRLTTGALTKADNRAVYQCCLIKTSLCTVDMCDSCSLNVEYRPEFSLPTVTPTGPIVVGGSLVLSCSAEANPQPPDFITWEKIGSPDSLTSVYSDGTSTLTLSSISRDQAGSYRCRGNNGVPPVVFSGSVDVIVHYEVSILNKVDTSVGAKDGYDATLVCEGKGNPLPRMTWSRPDGVELNNETDPGRIFQVDTIHEGDDVFGFTIRSTLHINPVTGTGDYGSYTCNSGNGIGMVDTLTVVLNDKVTPLPPQDVSVDQGTVTATSVTITWRPGIDVGEPQWFYVNIREVDTTTGFDPSTRVRIADGVVMHVIESLSPYTKYEIEVYAENANGVSQNVRRTATTLPDTPEKLDISVTTNQETGIISVGGIPQDGDTLSCLRLEARLTNQDDWFDYGECLETNTDLALREARSRYCYGDLCSQATTAITVAGQSSNAGLIAGIAILAVMVLISIALNVVVIMYVKRRGPQPETKKRISIPKFKPEDKRPVINEAEEYQDLDVPLQILAVGGSPNPAASTYASISETLAEFSREKLTIVRELGQGAFGKVLLGNANGIVQQGTVTQVAVKTLRDDADITERGDLLRELDFMKKLPSHSNVVKLLGFCIDRDPIYIIMEYMSKGQLKELLTSSRGKGKLQVYSNLHGRSKSLTSKDLIKFATDVADGMAFLASQQCIHRDLAARNVLVGENMICKVSDFGLARDVKNMRVYQRKSEARLPIRWMALESVVDDVYTTESDLWSYGILLWEIVTLGARPYPTMSFKTMISELQEGYRMPRPEHCQDELYQMMLACWEEEPTARPSFTEIGQKLEKLLEGAHDYITLSDYQEFDYEVTIPDSPDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQT1</accession>
    <name>A0A914AQT1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066122.1">
        <property type="nucleotide sequence ID" value="XM_038210194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210194.1">
        <property type="protein sequence ID" value="XP_038066122.1"/>
        <property type="gene ID" value="LOC119736172"/>
    </dbReference>
    <dbReference type="GeneID" id="119736172"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="125" mass="14199" checksum="C5108BA17BE942E4" modified="2023-02-22" version="1">MVYENNDDFQFPSLIPDDISNPVSASVARWTGHLEISLEVWDVDPDGGDDEIYTGKKTISQKAASSVSSAVWTDYSMGTDTTFQFSVRVYCESEYQGPDCGMWCHDTDNQNSFFEIKQKRDMEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR35</accession>
    <name>A0A914AR35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Virilizer N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vir family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066520.1">
        <property type="nucleotide sequence ID" value="XM_038210592.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210592.1">
        <property type="protein sequence ID" value="XP_038066520.1"/>
        <property type="gene ID" value="LOC119736576"/>
    </dbReference>
    <dbReference type="GeneID" id="119736576"/>
    <dbReference type="CTD" id="25962"/>
    <dbReference type="OMA" id="YWLEPLP"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031801">
        <property type="entry name" value="VIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15912">
        <property type="entry name" value="VIR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Virilizer N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1400"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1792"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1878"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1792"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1895"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1941"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1971"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2002"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2044"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2064"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2079"/>
            <end position="2099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2133" mass="232953" checksum="7CBC093803B296BC" modified="2023-02-22" version="1">MPKMAEENMLELLFCDTFSHENKEELNLDLVQFPWPVCISEVRIIPRATVAHPELQDQGRLGETSPSTFKLELFINNLSKPGSAVFEQLGALDYVDNSKIQLVTNNTAPTDGVVLRGWYHKVTVAIYGILASHKKRAEERSVSPPPPPPPPKQSIHGAKRAVDDTTEFLPHEMTQKKQPLHPQQHHNWDWEQQEHDQSAAAKRARYAEPAPEPTEHHQPPQPVSHAIPSTTSSRRGPRTPSPPPPAQEQWEPSQPRSGESWPTGDAAPKDPWKTQEAWEAGVEPEEPSQGRDWEHGDTWETTDTWEPGDAPEWDEPATPVEPPNQKQPYPEPWREDHARVPAASSGSSGRTQKKHRKHRGPRTPPGEPRGSPTSPDYAPPGDQYTQDSRRHREGSRRRGVDSPRREVRRDKESRREGEVRRDPESRRESEEPSLTTEPGEIVQETAEVGEELFEPLTPETSPSHQYSDRENIEDDRSREATEEAEMESIGQAYEEISDEEGMDEVGSLDGLMDPEGLEVDGLEGESWPDIVTFDPFQVELVPLTTFPAPYPSPQDQAKPAKRDAPSVDSKTVLDVLKEHRDKGYGPRWVAALEPLPALLPQALTGLDDRSLSTLAEWSVEALSQDRARGQPIGVNMRQLKAGLRLVSALCNCSQRVASKLLNLGVLDGLMSLLFGDHVASSLKLMALNALDSATNWQEGVQRLLGSSPSVGVLADAPRTYYQRLVKLLLSEQTVRVVTATTALLKKIHVYEVLTTLHDTVESILDTDAEPSSYPAASLKQTSKFDPSDPDVPQQSSGPGTPLEGEVMGECGGVSSADIETVVDCLQELSAVLRTASYSLVQPPIKAFPTTAKVTGPPNSADPYPALYHMFQTRNLLGSLLVLVSCPSTSGHESITSAAVELLTVIMKSLKGLLFLSAHQAATKSLCQCLTANLDDDSQEESPSQQAGLQLLHSLAVLQYVDQLQQAVAKGSPTAHDPDRDEVIEVLRWLCSVSFTAVGRTALAHVFAMDDNLECLLPFVEPRAEQGGSPTRSRKTASHGYAMQVLSCIIQHNENIATLTKYQARLELCCVGDSALSKWLTPIQGVRLDGDCIPKMIEHINKESDELGHNLLGTGPGIVTCLRVLRHLACAPRDMQTGDCQKDFKYKLAVIQLYSSSSMNAFINIIKRLGDRLLRPWQQGYSLSTTQVHLVDALVSPVLQLVKVMLSELLSSGSVQFKDERLVTYLLPLHTVLCSVPSSIMLPSDAQRIQTDIIDILLSYTMMPGTQPDTEEGIASSSWTVMLKEVLQFIPSAAYAYIGGLTVLSELLPLPLPMQAQEPLSAVEVQQALNLRRLWSLHLHSESVHIQQIIKDLAGSSCPPLQQILRRVCWQLADLAAPTALTVVRSLLDILIENLAQGEEGGKKAQPASGETAGEGEEIQKKTQPCNSDSARILTLVVYLVSQPAIKAPLLHLFRSSLKSDEKYSELLPWLLSLLNVVSDSSFHLQAQECIVALLQSICGPEITLLPTDNLSISEQLANSLPGKEHMEIICSALLDHVTSSDQSYASILPSLRTLSMLLDYDYGFVFVKCALDKTPSAFHSLFTRLQTSFHKDSSDYLSTLSTTLDLLQMLLTVEGPSSTEGLDQEACPEEGGPYRTKVLSVGQLKEYLMWGGKAHPVYQLEKTLIECCKEDEILESLLDSISSLIQTLDSPEEPTPTTLPSAPPLPKTNPALLQELTLLPAPLSFSEQFNSRLVFYIGEGEDDRLNTGFWLGPPGIDDGDIEPDMVQCDLEDLRSTYLPDLDLRAELEKDLSAENLPREKDQKKRSGKRRYESLTSRSQYRFNYGIKRAHNQGGNFNQYGRPMSGRSGRGYDIFRQRAQNTSRPPSMHVDDFLAAQAIESTDTKKPQRGPPQGRSGRGGNFMGGGGGGGGGQRGGGGGGSFQGGRGPWNGPTGNYGRRDGGGNNMGSGAQRGGGRGGGGQWGNRQQQRPGYGSGGGGGGAGGGNNQQRNFGQRRWEGNQSRPDNRLDSRQEGRGPASGQQAYGRMGGDNRASREGSYMQRGDPRGSGGSMRGGGSGGGGGQQRGGASMRRPGQGFRPGSAGGGRGRGGGGGSGWSGQGGKDQYSRFQQTPKTGRGGRMGARENQGRHSRSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR79</accession>
    <name>A0A914AR79_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066560.1">
        <property type="nucleotide sequence ID" value="XM_038210632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR79"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210632.1">
        <property type="protein sequence ID" value="XP_038066560.1"/>
        <property type="gene ID" value="LOC119736619"/>
    </dbReference>
    <dbReference type="GeneID" id="119736619"/>
    <dbReference type="OMA" id="NASENDW"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="245"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="515"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="335"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="809" mass="87270" checksum="9418533E8E53D314" modified="2023-02-22" version="1">MTSCGRHIFGWNCEFNCESAASSNICNGQFGLPDPYGNSCISGYTGIYCNVNCPSGTFGAGCTQTCRCQAGNAACDRFTGVCTPSGCQAGWSGTSCQISGACITGKFGLDCSSDCQCSNNAACERDSGYCSGSNGVCAGGFKSDMNANNCQTGIIEFQMLTMPNQGQDVTFSCAATSGDALLANSIVLGSSGSAGFTRTETVTEGTVLNNTFTASGLTNNQLVVCSLFHNSQSVSTTLSVSLFVLPYLSQAPEVVAGPGSVTVSWQAWDSHNLDSGDGPIIKYIIYYMLSTSASWTMAGEISVTDQSQAAYSFVVQPLEPSTHYQFSVAAVRDGPGGQGSLSPASQLIYPLTPPPKTPPPTTEGPTVAESSTLPAPPITTLPAPTASVVVTGSSSTTTPQPTSADESNTVLIAVIVIVVIVMIVVAAVLCIYFLRRRRSRRQPAKPPSTGGQELTAYENQISPDNGTGASDYERVGHDHPTSYEVVGINMSPPTYEDVGLPSWTQQWRIPWEEMMVGKKVLGEGNFGEVRDGAVLVGEDISKAAIKTLKANASENDWQNFMEEFRTLTKVGRHPNVVSILGACQHEDILYVALEFMPNGDLRTYLRNARSLGDDDQSTLSPEKLIQFALDVVKGMQHLDAVGVIHRDLAARNILLDSQLVAKVSDFGLSRGEDIYVQMSRTRVPTRWLSLESLASKIYTPKSDVWSFGILLWEIATLGATPYEDTKSKDLLSRLKSGYRMPKPSSCDDEFYNLMLLCWQEDPAHRPHFKKLVARLTSMGDSQNEHTYMRLLPKADNYMYLMIRPELDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS30</accession>
    <name>A0A914AS30_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066458.1">
        <property type="nucleotide sequence ID" value="XM_038210530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS30"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210530.1">
        <property type="protein sequence ID" value="XP_038066458.1"/>
        <property type="gene ID" value="LOC119736517"/>
    </dbReference>
    <dbReference type="GeneID" id="119736517"/>
    <dbReference type="OMA" id="MASMHET"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="107"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="48404" checksum="B268C665800A65DA" modified="2023-02-22" version="1">MIHDPDQYPRETNKEFLDPDQQLGIHGSRYEACDVSFYIKDSNTHSDIQCTENNRPYYSAYNYTYTSTIMNATTVIPVTASPPLYSYQARIGLACVWILAAVLGLVGNSLVIWSVVLSKKLRTVTNAFVVNLSLVDFWTSLSYPWQAVAILSHGSWPLATEVPCYIAAVQFYTGLGGSLYSLAAIAFNRFMLVTQKTETYSRWYSPGKVSVMIAATWVIPSIVFFLPPILGIGDFGYDPQDNTCSDKDGHPRGQEYNLAQSLGLYPIPMLIIVSSYTALYIHLKRHFRKQKRRRAQQGSPSQDVDGGTVGESTVSFTVVSESSPVPANDMTKGIRREISRQQLAITKNLFMVFFIFFLLMSPYFISLAIPSSGAFALYGATISMLNSCVNPIIYTAKHPQFKLVLRKILRCRYSQIPEPSDWLKSILSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS37</accession>
    <name>A0A914AS37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066186.1">
        <property type="nucleotide sequence ID" value="XM_038210258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210258.1">
        <property type="protein sequence ID" value="XP_038066186.1"/>
        <property type="gene ID" value="LOC119736221"/>
    </dbReference>
    <dbReference type="GeneID" id="119736221"/>
    <dbReference type="OMA" id="WWDMVVR"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="42912" checksum="7CFC03A671EE775D" modified="2023-02-22" version="1">MPTKRRNREKSTLNGRENVANGNTVLNSGSVHDHDDHRAVRVVNGDSNSKSLCSNSRPRPASWKTIAKATVLCCVAVYFLIPGLAPVVPLMSKQFLYLNIVKNPFSPSLQYPEQQNLTGARNLHIGTLPPDPSIRLGMWQILPQSLQNGGSIQDDSQFDEALGDGKPIILYLHGNAGSRAADHRLLLYRLLIGMDFHVVALDYRGFGDSSGWPSAEGVVDDAESSYRWVLERSKGAPIYVWGHSMGSGIGSAMVKRLCKSGLCPQGLILESPYSSMHDAMMNHPFTVPWRFVPGCLALISKAYEEEEAMFDSKENLLDVQCPVLIIHSEDDFVVPYKLGKRLYDYSVEHRAKSLPPVTFHSFGDAGFGHRHIVDAPDLPEVIRNFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASB6</accession>
    <name>A0A914ASB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066553.1">
        <property type="nucleotide sequence ID" value="XM_038210625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210625.1">
        <property type="protein sequence ID" value="XP_038066553.1"/>
        <property type="gene ID" value="LOC119736609"/>
    </dbReference>
    <dbReference type="GeneID" id="119736609"/>
    <dbReference type="OrthoDB" id="10167610at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="160" mass="17389" checksum="F45394AB7B0EA38E" modified="2023-02-22" version="1">MKGGQIDVYNKVPTVSPSRPYPTVIGCNQDHDADTCEVRVRHDSTMHDLTCVMEQVKPAVELKWFLGGLTELKASTAVRSVVLPANTGSSLRNNTYSTSAIIQVPSDYSDIEYVCEAMGVAVGSSSTRTRVRLTKTEPTTATYDEVQSSSNPGLSKEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASB8</accession>
    <name>A0A914ASB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066261.1">
        <property type="nucleotide sequence ID" value="XM_038210333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210333.1">
        <property type="protein sequence ID" value="XP_038066261.1"/>
        <property type="gene ID" value="LOC119736288"/>
    </dbReference>
    <dbReference type="GeneID" id="119736288"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="182"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="594" mass="67097" checksum="862A2B66CC1CE532" modified="2023-02-22" version="1">MMKVWVKSILLVITLSVYIALGSLAFVLIERDSSVAGQRVLRAQVKRFIANHSECVDAEAMRSLWQDIQTVWSRSVLHLPVKAGGPWRDTWRIQNAYVFCYTVVTTMGFGWITPSTLWGRIFCVVFAIPGIALNGYMLSVIGSTCQVVWIKCFNLFVRGTSSVKSQRVRNILGVLVTFMILWVVLIMIPAAIFVPLENWSLLTAQYFNFVALSTVGFGDIAPSHAALPPQYRTETGEYLYRVGVMLYFLISMAVFSTVFTGVWRYHKQRMFKAVGSGSSRLMMMIRGQSRLSREGVGHHNEAVELEDEAVELEDQAGECEDEAVKIESVSVELEDEAVACEVEVVERKDEAVELEDEAVELENQAGEREDEAVKIEGVAVELEDMAVECEVEVVERKDEAVERKDQAGERKGEAVELDDQAGEREVEVFERKDEVVELEDQAVELEDEAVERKDQAGERKDEAVERKDQAGEREVEAVELEDQAGEREVEVVERKDEAVELEDEAVERKDQAGERKGEAVELDDQAGEHEVEVVERKDEAVELEDQAKEREVEVVERKDEAVELEDQAGKRKDEAVEHKDEAVELEHEAVELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AST1</accession>
    <name>A0A914AST1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066718.1">
        <property type="nucleotide sequence ID" value="XM_038210790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AST1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210790.1">
        <property type="protein sequence ID" value="XP_038066718.1"/>
        <property type="gene ID" value="LOC119736777"/>
    </dbReference>
    <dbReference type="GeneID" id="119736777"/>
    <dbReference type="CTD" id="221458"/>
    <dbReference type="OMA" id="DFDLWYQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF67">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="634"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="912" mass="102377" checksum="C4402798C4A2E396" modified="2023-02-22" version="1">MVKQGIKIFCRIKPTKAKTGLFEIDEDDSGFPKLSVVVPKDLASGFINNKKEEYSFRFDGLFDQYTKQDEIFDNVAKDVIDNCLLGYNGTIFAYGQTGSGKTFTITGGPERFIDRGIIPRMLTYLFEEYAKNPGHVYTTHISYLEIYNESGYDLLDPKHEAAKLEDLPKVSLMEDSDGNIHLKNLSIHQASNEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHVSVREAGSATIRRAKLHLVDLAGSERVGKTGVGGTLLTEAKYINLSLHYLEQVIVALSEKSRTHIPYRNSMMTSVLRDSLGGNCMTTMIATCSVEKKNIDESISTCRFAQRVALIKNDAFLNEEIDPKLMIARLKAEIQELKNQLALATGEQSMDELTDEDRERLTELVDSYIQDSDPEATLNVGADMRKINECFRMLKRLAQGKGFASGGSRQKQREEERMEEQRMPNEDPMSSIDSVSTVNQAEMNKMKELLKQRDNEINILVNMLKKEKKRAQDALSQLHNRAGSHQPDLSASSSDQDIPNGYNSNITSSRASDKSQEPHRSHGRRSRQGRTQSDEDYRSRDRDRQSVDQSDAMLRSGDGARHKVESSSSSYRLKDSKRKILGDMSVGRQEAFEIFRRDYPNNAGIEDNKQQLKQRYSEAKAKGQFVNECRQNINKLKSQIEHRRLQLAMSGEQDPGQPDEVEQALRQQMEQEKANYKEIFNHLRSLKTEIEHLQHFLEKSRLQLQKDFELWWAEQAANVQAQQSLPQPQPPTAPPSNPSKAWRTPPISPLKDQVSDHHTTTATPHHQGHLPQSTVYTADPASARRPYSGTSRNALLGALSAQVDRGGGRPPVVPPLGKPSSAGGVEGPESKSSSRRSRSLVDSSGQSAVQLTGDKRADADIMAFIKARQNLLQARGQAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWN8</accession>
    <name>A0A914AWN8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067924.1">
        <property type="nucleotide sequence ID" value="XM_038211996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWN8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211996.1">
        <property type="protein sequence ID" value="XP_038067924.1"/>
        <property type="gene ID" value="LOC119737553"/>
    </dbReference>
    <dbReference type="GeneID" id="119737553"/>
    <dbReference type="OMA" id="MPFTVGM"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="268" mass="29987" checksum="150C018B2A1B3CA3" modified="2023-02-22" version="1">MAEAVPAGIHLRFVDDIAVMWLNNGENRLNINSLRAMNAVLDQVESNESTKALIITGVGKYFSCGLDLAWLSKQDDDTLTTFFSAFDQFLARLLVYPMPTVAAINGHAYAAGGFMAVACDYRIMRTQRGWFCFPEINIKLPLQPPTVEMIRVQCSIVCACRMKIRDNLVFRDLVMYGQRVTGEEAKEKGVVDKCVDMKDLMDTAIAFTRERIGADGFDRTTVHLMKHNLYGIIVEKSKRDISGAAAGKLDTQEQLKRAHDARQGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYU2</accession>
    <name>A0A914AYU2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069320.1">
        <property type="nucleotide sequence ID" value="XM_038213392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213392.1">
        <property type="protein sequence ID" value="XP_038069320.1"/>
        <property type="gene ID" value="LOC119738488"/>
    </dbReference>
    <dbReference type="GeneID" id="119738488"/>
    <dbReference type="OMA" id="RLNCARM"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034619" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27620" checksum="E222EAD2372E8935" modified="2023-02-22" version="1">MAWWTARFVLILVSIFINLPSCQALYASCPPGWLKWQQSCYIRLPNRMNWFEASEACNRPGSSLAVPNSREENDFIWKSVGPQTNGMWIGCTDAAQEGIWLCGGQPLAFSNWYPGNPLTDNQRNCARMTIHDAGGLWSDNAPCGSKNRKHAACEMTVSAMPAYHTFTGPDGRVPQRCLLHHDIKNLTAEGVLDCGWACRADPRCRSFNLWQSSKREKMCQLNDVIHLGADVTDYKATNNCYYFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZA9</accession>
    <name>A0A914AZA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBXO31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069037.1">
        <property type="nucleotide sequence ID" value="XM_038213109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213109.1">
        <property type="protein sequence ID" value="XP_038069037.1"/>
        <property type="gene ID" value="LOC119738272"/>
    </dbReference>
    <dbReference type="GeneID" id="119738272"/>
    <dbReference type="CTD" id="79791"/>
    <dbReference type="OMA" id="CCKPEKH"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="410" mass="46889" checksum="C90E2A90FCD92CCE" modified="2023-02-22" version="1">MDRRSTCTIADLPPEILAYMLSKLSGPTIAKVAVVCKQFYEASKIETIWQHRCFEDYGFTSDELDGWGIESFRIVYIKVLYPYSHVIGVWQPQIGSYGGLVSIKIRDGAIRAAQYLPPVDPKVCMPLRRKELFQIQLTSEGFTQTECLKGPHGPHKLQILRGGGEGEFVLKCCKPEKHRYHNSRQEELQEWIRQEIGAKEGEILLFNYDHHIELLRIKYIILNQYDENCAFQRLHLPGPQPNEPIQPGLFKGTYGGHGIEIISLKYEEDKLRGYKVTGDPNVPACQLSIEVHLDEPMVLGSAEQETLAMLESVDRDDVLIRDPKDLPSSQPFLVPAGVHDHGMGDVGRKLNMDLKRCRRRYYGTGLIAMHGFRNSSRTPCHFILFNEEVFALLWLELHSISIFHRVCEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZJ6</accession>
    <name>A0A914AZJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068944.1">
        <property type="nucleotide sequence ID" value="XM_038213016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213016.1">
        <property type="protein sequence ID" value="XP_038068944.1"/>
        <property type="gene ID" value="LOC119738229"/>
    </dbReference>
    <dbReference type="GeneID" id="119738229"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037805292" description="Protein kinase domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="435"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="724" mass="80994" checksum="A44B7F15A5482CED" modified="2023-02-22" version="1">MASNTIVFVLVILGLFLSQCHCPWVRTGNPGGHKSEGSCELYLTRNVSALVEGIPVQFACSVGRYCKRDGRIRVFLNGSPTDEPISDASTSNMSFVPDRNYSGLLLECMYLDGGLQSLVKSITLDVTFPPKRVAVSSSSMNCNRTCRAELIPWQTYEFKCRSVDSNPPCTFNWTLEDPDGRAPAITPENATWVVSKTLDAGWDATSSVRLEALPNYHRRIMRFPPKRVAVSSSSMNCNRTCRAELIPWQTYEFKCRSVDSYPPCTFNWTLEDPDGRAPAITPENATWVVSKTLDAGWDATSSVRLEALPNYHRRIMRCSVLHPNNLTVFREISQVLLVNTEVVVVVSTAGSPGIATILIVGCSLELLAALCILAYAIIINYVCARKTEKRGTTPPEPDQSSAVQGECDLPVDEIDDISLAEDHAQKVRSFKPDRITVLHKLGEGAFCVIYKGIADGITQEGRQDTVAVKMLKAWVPGSSEVINFMKELNICRTLEEHPYVIRTLGCCLEQEPYCLIFEYAPNGNLANFLKEKKREWRDKSHIAPISSDQIIKFACQIASGMHYLSSMKIIHRDLAAHNILLGEDLMCKVSDFGFSRDIIAKEFYQMSSSGAVPLRWMALESIVDNIYTSKSDVWSYGILLWEMVTMGTHPYPGIEVEDIIDALKNGRRLPQPSHCGDKLYTVMKECWHPTPTSRPKFDSILNDVVSMSNDPSKYLQMSKFTEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B188</accession>
    <name>A0A914B188_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069554.1">
        <property type="nucleotide sequence ID" value="XM_038213626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B188"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213626.1">
        <property type="protein sequence ID" value="XP_038069554.1"/>
        <property type="gene ID" value="LOC119738698"/>
    </dbReference>
    <dbReference type="GeneID" id="119738698"/>
    <dbReference type="OMA" id="HACLARQ"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000024">
        <property type="entry name" value="TBC1 domain family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="218" mass="24405" checksum="75892344F82E1FDB" modified="2023-02-22" version="1">MDSTMDRTRHMLNYLLPIIKKANVELYDFMERSEVGTVFALAWLITWYGHVLNDFRSVVRLYDFFLACHPLMPVYLAAAIVLYRQEEVLACECDMAFVHSLLSKIPGNLPMEYLVSQAGDLFVQYPPAEMAKEARLQYKLSTSMSKHPDFELETLYQRPDKVLQHMSSRINGAAGTPTTADSQTGSRSSGVIKLAVWAISAGIGAAALAVLNTAGEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B217</accession>
    <name>A0A914B217_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 9">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8 9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 9"/>
    <dbReference type="RefSeq" id="XP_038070052.1">
        <property type="nucleotide sequence ID" value="XM_038214124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B217"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214124.1">
        <property type="protein sequence ID" value="XP_038070052.1"/>
        <property type="gene ID" value="LOC119739264"/>
    </dbReference>
    <dbReference type="GeneID" id="119739264"/>
    <dbReference type="CTD" id="191"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="195"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="435" mass="47979" checksum="3D797CA8443A2363" modified="2023-02-22" version="1">MASNGGKLPYKVADISLAEFGRKEIVLAEHEMPGLMEMRKKYGSTKPLKGARIAGCLHMTIQTAVLIETLTELGAEVQWSSCNIFSTQDHAAAAMAKVGVPVYAWKGETDEEYIWCVDQTIVFPDGQPLNLILDDGGDLTNLVHEKYPQFLPGIKGLSEETTTGVHNLYKMMKEGKLKTPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDIMLAGKVCVVAGYGDVGKGSAQSLRAFGARVLITEIDPIIALQAAMEGYEVTTMDDACSRASIFVTATGCANIITAEHFPKMKENAIICNIGHFDCELDLQWLEDNATKDNIKPQVDRFTLPSGRHLIVLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTKSDQYPLGVYMLPKKLDEEVARLHLDHIGVKLTTLTKKQSEYLSMPVEGPYKPEFYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5M7</accession>
    <name>A0A914B5M7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ectonucleoside triphosphate diphosphohydrolase 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071120.1">
        <property type="nucleotide sequence ID" value="XM_038215192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215192.1">
        <property type="protein sequence ID" value="XP_038071120.1"/>
        <property type="gene ID" value="LOC119740007"/>
    </dbReference>
    <dbReference type="GeneID" id="119740007"/>
    <dbReference type="OMA" id="ENPFHRH"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24045">
        <property type="entry name" value="ASKHA_NBD_NTPDase4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000057">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000003">
        <property type="entry name" value="ectonucleoside triphosphate diphosphohydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70137" checksum="97E3EF2E697B2818" modified="2023-02-22" version="1">MARWKPTCLHLPASWHINLRLTTSNVRRTACLFFALTLIGLILIFYLEVEMTPVMHDPLNDLINKYELLEVTDTKDENLYYGVVIDAGSSGTRVYVYFWPRHIGDTNRLLRIHQMRDKRRKPVVMKIKPGLATLASSPSEASDYLKPLLDYAASHIPSAKHPESPLYILATAGMRMLPLSQQEAILQDLKTDIPKDYNFLFSDTQVEVISGKQEGVYAWIGINYVLGRFDHANDNDAMVEVDVAGENGPVSVLRTRTVGILDMGGGSAQIAFEVPHTVSFDGSDPQEDVAKGMLAEFNLGCDVHKTEHLYRVYVTTFLGYGGNAARTRYEKALVNTTFSNTKSTANPPGLKEDSPYLDPCLPVHMQDKITHGGHTIYMKGTGDYKQCQSSLVPLMNLTVPCPKQPCSFNGVFQPEIEFRNSEFYGFSEYWYCMEDVLRMGGMYEYVKFEKAAKDYCATRWSLIQEHQDKGLYTKADAHRLKYQCFKSAWITTVLHKGFGFPENYKYLRTASLIQDKEVQWTLGAILHRTRFFPLREIQLGVFQKQVPPPWVHASQVSNQYILISCFVVVCIFIFLYLRWLRVLGPRPLPRVPTMAYFMTDEGQIQEGIQETGAVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7N1</accession>
    <name>A0A914B7N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071984.1">
        <property type="nucleotide sequence ID" value="XM_038216056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216056.1">
        <property type="protein sequence ID" value="XP_038071984.1"/>
        <property type="gene ID" value="LOC119740681"/>
    </dbReference>
    <dbReference type="GeneID" id="119740681"/>
    <dbReference type="OrthoDB" id="6340082at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869492" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="19818" checksum="BD994745E6552390" modified="2023-02-22" version="1">MSCGKVGILVSMTLLLSGSLSLSPSCNRRHGLCTAPWKKWGGSCYLITQKPLTYDDAREACRRLGANMAAPHSDQENNFLASLAQGSDIWVACTDRRQEGEWECDGSQDGQGIYTNWWVARGQPDNIGGNEHCATIWSPDKKWNDYRCNGEQLAVCKQQPLTHCFITNSDGRLEADSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B940</accession>
    <name>A0A914B940_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072345.1">
        <property type="nucleotide sequence ID" value="XM_038216417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B940"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216417.1">
        <property type="protein sequence ID" value="XP_038072345.1"/>
        <property type="gene ID" value="LOC119740928"/>
    </dbReference>
    <dbReference type="GeneID" id="119740928"/>
    <dbReference type="OMA" id="VYHKPTD"/>
    <dbReference type="OrthoDB" id="522106at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22975">
        <property type="entry name" value="DD_TEX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040760">
        <property type="entry name" value="Tex55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048377">
        <property type="entry name" value="TEX55_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47110">
        <property type="entry name" value="TESTIS-SPECIFIC EXPRESSED PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47110:SF3">
        <property type="entry name" value="TESTIS-SPECIFIC EXPRESSED PROTEIN 55-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17819">
        <property type="entry name" value="Tex55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="151" mass="16909" checksum="993C7D04E090CBF2" modified="2023-02-22" version="1">MAAASETANAEVTNTNSDDMNSSQPVLLTEGSFSVENGSSEQKQDGGSGVEGAEGEAAEETLSQKIDRLEELNKEEQQDELKYVPPLQDPYSRSVKYMEKHNIMQIFQHLTAEIVYHKPTDPLQHMLEELNRMVADRELKREEALKSAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA52</accession>
    <name>A0A914BA52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072879.1">
        <property type="nucleotide sequence ID" value="XM_038216951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216951.1">
        <property type="protein sequence ID" value="XP_038072879.1"/>
        <property type="gene ID" value="LOC119741217"/>
    </dbReference>
    <dbReference type="GeneID" id="119741217"/>
    <dbReference type="CTD" id="321346"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="277" mass="30577" checksum="2F648890F4E583AF" modified="2023-02-22" version="1">MAGAGLNRLFSQLGKLGIGLAVVGGVVNTALYNVEAGHRAVIFDRFSGVKDYVMGEGTHFLIPWVQRPIIYDCRSRPRNIPSITGSKDLQNVNITLRILYRPEVTNLPKLYVNLGEDYDERVLPSITNEVLKAIVAQFDASELITQREVVSQRVNAELTERGSQFGLILDDISLTHLTFGREFTEAVEMKQVAQQDAERARFLVEKAEQQKQAAVITAEGDSQAASLLASAFTKAGDALIELRKLEAAEDVAFQMSRSRNINYLPPGQQTLLSLPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAB7</accession>
    <name>A0A914BAB7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="9">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038073031.1">
        <property type="nucleotide sequence ID" value="XM_038217103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217103.1">
        <property type="protein sequence ID" value="XP_038073031.1"/>
        <property type="gene ID" value="LOC119741354"/>
    </dbReference>
    <dbReference type="GeneID" id="119741354"/>
    <dbReference type="OMA" id="QTARSQC"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="12">
        <location>
            <begin position="125"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="280" mass="31096" checksum="6C2461B6BF688FFD" modified="2023-02-22" version="1">MIKTVFHILPALSSLADDEFLEPQLFERDCPSLWSSTGKAHPVVRLYNPEKSLIQDEYRLTLAVQPSSLQASPGGSFTNSASEVCDKELNVQKKIIPWQDTVMPGFDDVIRTVGQEEKGSRRGSLVLVASLIDKAPNLGGLCRTSQIFGVSTLVVNNLRVTADKIFQTLSVTAEKWLPIIEVPVSDLASYLQAMRHKGYTLVGVEQTARSQCLTKYQFPERTLLLLGHERTGIPVELIQLLDVCVEIPQQGIIRSLNVHVSGALLVWEYTRQRLLAQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAI5</accession>
    <name>A0A914BAI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM161A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072845.1">
        <property type="nucleotide sequence ID" value="XM_038216917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216917.1">
        <property type="protein sequence ID" value="XP_038072845.1"/>
        <property type="gene ID" value="LOC119741194"/>
    </dbReference>
    <dbReference type="GeneID" id="119741194"/>
    <dbReference type="OMA" id="RENRWPY"/>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF1">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="751"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="96729" checksum="CDB6797293ED4193" modified="2023-02-22" version="1">MATTFGGHGLSSLTNSCVKVPINPRNRLAATFTERGGSFKPKSAKKTEDEQREWENDTAQNGTRFAHSNPSHVHHRHSHSHSHDSHNGNGYFETENGFTSTDMDDGKHEPDDYQDVHARPRPDQLFENLKDNIDAYTDEEFYKKLMEMKDEHRKTLNRLEVLYDQKLSLSGHENIPKTNFELEEQPFTKSGPVYIGDHKLRHIDDEIEQFTKSQDWSTKKDNVKDMSAKPPIGRPKTAWAGKSRRSLRRSMPSEKWSDITWTNDSGQDTSGSELDASNASTTRSRRTLNLSDSYSASQDMVGRMWDDFSVEEYAPRARSNSRASSVKSTGSVKSKEWSPKITIPKPFQMTQREAMKEKTKSRACMELEQELAEKEKAEEVECQRKFKATPAPAHTYMPLYDEINERDTERSRRNRENSKDRLVSQQKPFSFMKREEEKKKHRRSKSLPLTQAKGKKPKQFKAREIPKTVFDPTVSDRILEEEEYRKIRIKMRAEEMLMQSSLPQNMQHRGKEYTDGKMRRNLYKKREKMAFLTTEHKFQPQVNGEVPDYDELYRQFQQEVQRKKQEKEPTVVQPFNLRTSRIPSKMDKILDEMKQEEDGRKEKLRGSTSKSLSLRSSLNISEDAIPAKTTAASKLRKSATEKTLKEQAEKEREEAERERQKRIKERKLKQFINRKALANDNSESLSATSKSKRQNYIEAGRSRQAEYDQQLKEMMTRVESRPLLFERQSQVNAKKAAEKKYQQALKEAGLDEEFLVRKGRSGSTQASARSYDYPDDSDEDLTFGRHEDRDMSFGSSKGGAGLRSEGGSRGYDNDFDDEEDDDENRSISSIHTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCU7</accession>
    <name>A0A914BCU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073670.1">
        <property type="nucleotide sequence ID" value="XM_038217742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217742.1">
        <property type="protein sequence ID" value="XP_038073670.1"/>
        <property type="gene ID" value="LOC119741832"/>
    </dbReference>
    <dbReference type="GeneID" id="119741832"/>
    <dbReference type="CTD" id="51079"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="18127" checksum="B0FC9582EF94F973" modified="2023-02-22" version="1">MFAVGQVDRSSNMASTFKQDMPPKGGYPPIDYKRVLPKRGMSGYMMFATCAAVMGVGTFFFGRHNRQRRLWQREEYESFIGIMPLLKAEDDRQKLKILKSNFEQEAIIMKDVPGWKAGESIYESKRWMDPMLVDLYYLHPKKVRDKELFGFSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDZ4</accession>
    <name>A0A914BDZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA alkylation repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074080.1">
        <property type="nucleotide sequence ID" value="XM_038218152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218152.1">
        <property type="protein sequence ID" value="XP_038074080.1"/>
        <property type="gene ID" value="LOC119742119"/>
    </dbReference>
    <dbReference type="GeneID" id="119742119"/>
    <dbReference type="OMA" id="YFVCDYL"/>
    <dbReference type="OrthoDB" id="429969at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07064">
        <property type="entry name" value="AlkD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.290">
        <property type="entry name" value="ARM repeat domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1660.10">
        <property type="entry name" value="Hypothetical protein (EF3068)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31953" checksum="F09E0CB03DB542AC" modified="2023-02-22" version="1">MSTRRGRAVPTRDQAAKTPTTTKRKSRDEEEKSPAKKKAKTLQTDDADMATRIVATVTRHLRQAADPKRAPAMAKYMRNQFAFYGIASPELKSAFKDILAEIPIITISANLRGLMLSLWNEPERECHHIALKFGEKYRNLLGSTAGECRESASCLETLITTKSWWDTVDTISPNLVGYLATEKPTVMNPILDTWITHSNMWLRRAAILHQLKYKHNTDQDKLFRYCLLCCHEKEFFIQKSIGWALRNHFRIAPQAVKDFVKENEDKLAPLSKREALKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFT5</accession>
    <name>A0A914BFT5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rapamycin-insensitive companion of mTOR</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075118.1">
        <property type="nucleotide sequence ID" value="XM_038219190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219190.1">
        <property type="protein sequence ID" value="XP_038075118.1"/>
        <property type="gene ID" value="LOC119742924"/>
    </dbReference>
    <dbReference type="GeneID" id="119742924"/>
    <dbReference type="OMA" id="ETSMCLL"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="56"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="522"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="931"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1605"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1648"/>
            <end position="1668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1782" mass="200199" checksum="246468F0765DC725" modified="2023-02-22" version="1">MAATMYPRRSGRRPKGRHDSGDADVPLDLDKEPADNVRDILVHVVQERNINRGRRVAYLNNFVKVINHVSSIEKLGHPIMEMVGCLRLSLLHSTKEVRSAGIRALRYLLQDEAAVEAMMRLHIDYLVMRSLDICLANDIERVQALRFIRRIIAVAPSLCPISLVHTLVAIANDGMKERDRMVRPSLETLSELAIKSTEVFAAAGGLSALIMNILDTQHLRINEAIMLTVLHLLNHPHTRKYIRLNVDIEQVIAPYTDCHYRHNGDNNEQTNEEKEMRYCASRMAIVTLIRSWPGMIRLCRPEASGLQSLMSILCIPNEVHRKYLLQVLFDIFYIPIPEWTDDFDVALQSIDRYEMQPPWQLSEGFVAEEGKAILPHRAATRTNLTENHLALILLAFTNAGLLESIVEVISSGSEHLSNMATILLGELLHMADRLLPSECEQHHHCLPTLMILAASCDVPVLQRNRASAAITHLDRLHELNKRGPVPCSLFLSFIMSRSETFMAERKSKLNRDKMKQCMNKDTDDISTQASIKETQVLSGKDHTFWNWDLISCIIKKGGPCLRKFEDANISRFFRRLVEFYKPTSKQFSSVELPKSLVRPPSLQMHTLIGCQLVEFLFDGDESEAQFLLRDLAQDIADCFLEINMVPNNNIPPEAVFSPISIQTTLSQDYFLFIGKICHSSKGEKLMEKTGMFQYILDLCSSKGPEVLQKLITTCLNCSREGLGRTILSKLLTSTSESMRLYATGHLRVQLRAQIPFFQNWGMEMLVTQLYDKSSTVASEAVEIIEEACEDDTNLHSLVQIRPSLLHMGDRGVLLLTRFLSTPKGFKYLSEVNFVTHELEKWRSVYNRKYVTLVETEINEAFTCYQKPVYEGGFVRRSQNEKRKRRDVYVPVHLYGQLVQHRGGSETLEKQQHLHTLCDIVRYGDISSYSSILSLKAALWALGHTGTASYGLQLLSSESIVPDIIRLAEECEVFSVRGTCFYVLGLFSKTRPGADLLSSLGWESVRHTRMAYFPVLEERNNIFDELGRFTDPTGPPASPYSTMSESTYTLDSPKMELAEKLPELESPKLVVENDPDGKNVFFVSGEVSPYRSASPQPGFSEEEEEEEGDQQYVTDEKSPSLAPPVQRIGRRDRTKSSPTKMLAVEHRTRMSSSEVEMRTRGISADIVVRTRSGSHSDLPQRTPNHDNARYAKYATIGHTGALPRSSILRRVATMPAMEEPGNGQRKNGQRLTKLRSNSDASSKPHRSASPNPNMARFQSQSTPERLRAHSMRERTFNRRCDSNESGRSSFGTKSRSESFATDTTQTSGISSLHSNPNSPPPESSNSSVNTITSSQTVKGIHSSDTLRRKHNLNRTPSFMRRLSKTVSSSFNTPYSNVLETSAVFTTSRDAHGYAALKALRIHRQVSGDPSSQNTPRPASIGSHDELAYHVQERKKGLLVDGTVSINSLDVILGMPKPRSNTQTLSQSHGGEYLGLCLPVDVSLIFHTDESQYRGGRRPPSRTSSNTSGFQEFSCLDPSALIPDGRLRHEERHRQADSDSDSDNPMEPSDISRFAEPPVDASYDTQSEYRGRKGSGAARAEVEFTEDTKHQAEHCLLCTKMRARSTYEADEEEDDRLRSISEADSNLPPTRPRLRGSSAASGRYTPNSADMSSTSTGSGHSSSDSNQSSRMRQDTPKGRAMIRKEVLRLVINLGSSVGMKAQEQGLLSLKEKFPSTFENVCLYSDVAYLLGNCSYRLSARRFIQELFQDLKYSLLFEEAKEIQGVVEAGKQLEETSNVLSVVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG04</accession>
    <name>A0A914BG04_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074372.1">
        <property type="nucleotide sequence ID" value="XM_038218444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218444.1">
        <property type="protein sequence ID" value="XP_038074372.1"/>
        <property type="gene ID" value="LOC119742501"/>
    </dbReference>
    <dbReference type="GeneID" id="119742501"/>
    <dbReference type="OMA" id="PFPHVTN"/>
    <dbReference type="OrthoDB" id="2101615at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="48"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="40112" checksum="24CB765863C31490" modified="2023-02-22" version="1">MENQLIIAPTLPLVADNGSSLRENVLSRSGYTGFAVYLAVVIFFSVSGNVTVILLYASNRSLHNVVNILLLNVSVADLSVAVLGTPVSFAASAAGHWLLGPIGCTWYGFICTLSGCAQIVGIAAVSLHRYFLVVKPFVAKRLTTGGALVCVGFTWVYSLAVALPPVLGWSEFTREGAGISCSVSWHSGSRSYTFFIFTMILAIPMAIILFSYSQILFTVNKMAKCQVSNQRSREAEKKVTIMIIVMVLTFLVAWTPYAALSLYMALGGDSVSITPLTATLPSMFAKASTTYNPVIYFLLHKKFRKALLQTFSRRNRDRSLHISPTESILARKVPIGCQGRNMSTNKPRMDQRIQLAGACIIPPMQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHF8</accession>
    <name>A0A914BHF8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075529.1">
        <property type="nucleotide sequence ID" value="XM_038219601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHF8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219601.1">
        <property type="protein sequence ID" value="XP_038075529.1"/>
        <property type="gene ID" value="LOC119743216"/>
    </dbReference>
    <dbReference type="GeneID" id="119743216"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="15"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="474" mass="50858" checksum="67662DD971792D35" modified="2023-02-22" version="1">MVCPSGSRCGWWRWVVTFACFGQFFFTLGLLFNFSILFVSLQEDFHSSSALTGWLGSLSLALAGLASPLCSLLTHKLSGRIVTILGVIALCAGLLTTSFVPVPTLGYAFFTYSVLTGVGANLTTNASFALLLDWFAKANFSRASALALLGSSCGMLAFSPLLTALITHYGWRNALRILSGGILVIGIADGLLLADPPSTEDYAKAPDESPGDEKHELESMVPGKQVHDDGCIETDDDAREIDDRTTNDEEANISNQGSPELGEERHFRGRLISALTNPEAWAWYLATVFSFLGWTFFNINYASFMDGLGLDSNSIASVIMYFALAELGGKVLIAVIGDHLPFLALYLLMASCLFGTIVLGFLTIAKTFDVIVLLTVVSGVLRSGYTAQFTAAAELFHEQYGTNGVMVMTLVPTGIGVLISAPLAGVLYDVTGDYVLSLLIIAGLFVCASAAYIFIPVRRRINQAVHVSVNTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI23</accession>
    <name>A0A914BI23_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075928.1">
        <property type="nucleotide sequence ID" value="XM_038220000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220000.1">
        <property type="protein sequence ID" value="XP_038075928.1"/>
        <property type="gene ID" value="LOC119743581"/>
    </dbReference>
    <dbReference type="GeneID" id="119743581"/>
    <dbReference type="OMA" id="WKTIART"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000030">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="246"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="44019" checksum="DFF8FC1D9E85F209" modified="2023-02-22" version="1">MVRREHIHPLTLPILIVMCGVTVALVSGNNEKNLVAELLGSYGSKSARPVQNTHQTLNVTCRLLIAQIIEFNEPKQQLTINAWQRLSWRDEFLVWDPVDFGGQTELHVFPSDIWTPRLALMENVNFDFASIDDTEITISPNGTVNWYTPVIYQVSCKVDVRNFPFDVQQCNLTFLPWVYDKTGLALLNSIGADTKQTVFSEDGVWSLVDVDVAGVEVKYACCENPFSHIIYTLTLERSSSFYIFSILIPSVLLTTITLAVFWMPAESGEKISLGMTNLLAFVLFQQLIAGNMPPLGDQTPIITVYLFCMVVLGCASIFVAVYALRLYHTAPDKPIPKTVVGVVKCLSRQKIPVTWQAVSRMTDKAMFVLFLVASIVILLFTFISIKHDHTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKI6</accession>
    <name>A0A914BKI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HSac2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076435.1">
        <property type="nucleotide sequence ID" value="XM_038220507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220507.1">
        <property type="protein sequence ID" value="XP_038076435.1"/>
        <property type="gene ID" value="LOC119744536"/>
    </dbReference>
    <dbReference type="GeneID" id="119744536"/>
    <dbReference type="OMA" id="WNPWSSN"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="88"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="33331" checksum="D72541327A79C08D" modified="2023-02-22" version="1">MTDNQQANGNTSIEDNLDDSSMPEVSFQGGTLSLNSVETNLLHEEKKPTAPSTLPLANANNGANNANFVRGRPKSAPLSPVVQDGFYASKIGRLESAVLECKKATIKSDMDGEVQGVWLLTEIDHWDNEKERLAIVTDNSLLLVKYDFVAGAVREFQRINHIAVDALQIGVFSYPEKSLVSPRDGTGLRIIWSHGRQPTFMERWNPFCSTIPWLTLTSHPLEHSGTREEDTYQIDPFKNVYIQAINNWRLKQNQALSNVSSSPVTIVDAPIECDVMLGLASTVHNQSRLGFYRERGGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMI4</accession>
    <name>A0A914BMI4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038077497.1">
        <property type="nucleotide sequence ID" value="XM_038221569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077498.1">
        <property type="nucleotide sequence ID" value="XM_038221570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077499.1">
        <property type="nucleotide sequence ID" value="XM_038221571.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077500.1">
        <property type="nucleotide sequence ID" value="XM_038221572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMI4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221569.1">
        <property type="protein sequence ID" value="XP_038077497.1"/>
        <property type="gene ID" value="LOC119745303"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221570.1">
        <property type="protein sequence ID" value="XP_038077498.1"/>
        <property type="gene ID" value="LOC119745303"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221571.1">
        <property type="protein sequence ID" value="XP_038077499.1"/>
        <property type="gene ID" value="LOC119745303"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221572.1">
        <property type="protein sequence ID" value="XP_038077500.1"/>
        <property type="gene ID" value="LOC119745303"/>
    </dbReference>
    <dbReference type="GeneID" id="119745303"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000060">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="249"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129528" checksum="A4E96C35A3E34E15" modified="2023-02-22" version="1">MSTSSVASWVTAEVDSNENIECCGYKKNPLKTAVCYVVAVLSLGFLFLVFYWKEDWRLKCMCAPCHLKEADFVLIKDIYRRYHVCDIRRNLVKDNDGCSREMLRTILKKDVVDADGNLRFFKFQKIFFILDLALHEIFRLRGLESNTPCNAFLKQYAGGLSESQSEQRQVIYGKNDIYVRVRSIPVLLVQEVLNPFYIFQIFSIAVWLADEYIYYSACILIMSAISIAISLYTTRKQNLTLRSMVQSDTVVKVLRPNNKAVEVSEKVLVPGDVIIIPHHGCMMTCDAVLISGNCIVNESSLTGESVPVTKTPLPHQGDCMTEYCPIEHKRHSLFCGTKVIQTRQGDTDEVRAVVVQTGFSTAKGSLVQAIMYPKPMEFRLYRDALRFVGLLAVIAFVGLVYAIIMMTLKGATVSRIIIRALDIVTIAVPPALPAALTIGMVYAQIRLKAQQIFCISPQRINLSGTIDIFCFDKTGTLTEEGLDLLGVQMAENGRFLPMTTSVSSLPIGPFTSTMATCHSLAVVNDELSGDPIDLKMFQATDWTFKEPDRTSGEKFIKVEPPKDVIQMGDSYKEKGDYGISVLHLFPFSSALQRMSVIAQTEGDDRVVAYVKGSPEIISSLSKPETVPDNFQQVLSNYTQDGLRVLALAWKPIQYEGTLDNLKNMQRKNVEEELEFLGLMILENKLKPETRPVIEELNRANIRTIMITGDNLLTAMNVACKSGMCGPDDTVIHIQAETPECCDDSTPILTYKAVDKDHTPTGDQIETKNYFKNNEKEALEMKTIKDEVSPMLVNKPLAACRTHYAIDGATYDAIQQHHQDQLQNVIVKGTIFARFSPNQKMSLVEELQHLDYFVGMCGDGANDCGALKTAHAGISLSEAEASVASPFTSKIPNISCVPILIREGRAALVTSFEMFKFLAMYGLIQFMSVMILYSITSTLSDLQFNYIDLGLCTLTILLVSRGEAYEKISVKRPFTKLMTSPVLFSLVSQIIVVTLIQTATFLVLQAMPWYVPLVPIPDGRNRECQETTSLFLISCFQYIIMAVVYTPKPPFRQPIYKLRLYSAYLIITFVGTTLLLYVPTAHTVRVMEMVVLPDYVFKTCILALAFLNFAFSCVIEYILVPSPAFIRFVSCAAWRKSRPPKYTLLEMDYHCHGDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMR0</accession>
    <name>A0A914BMR0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077578.1">
        <property type="nucleotide sequence ID" value="XM_038221650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221650.1">
        <property type="protein sequence ID" value="XP_038077578.1"/>
        <property type="gene ID" value="LOC119745354"/>
    </dbReference>
    <dbReference type="GeneID" id="119745354"/>
    <dbReference type="OMA" id="FQPKMRF"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="862" mass="98928" checksum="D087E3A99BC1EC02" modified="2023-02-22" version="1">MGQLFRSERMVLSQVFLQSEAAYNCVAELGELGLVQFIDLSPHLNAFQRKYVNEVRRCDEMERKLRYVEKEVKGAKLTVNDSDTEVPAPHPREMIDLEANFEKIEVDMKEVNSNHETLQRNYLELTEHRHVLRNTTEFFAEAELFHQDREVEEARASGYSRFDVEEGVRQVRSQIKFGFVAGVIGRERVPSFEQTLWRVCRGNVFLRHMSIDEQLEDPSTGDEVFKHVFIAFFQGDQLGGRVKKVCEGFHATLYPCPENAMERSEMCTGVAKRLEDLKRVLVQTEDHRQRVLASAASNLWVWFVKVRKLKAIYHTLNLCNVDVTHKCLIAECWCPENELGRIRLALQHGNERSGSTVPSILNIVTTNEDPPTYNNTNKFTSAFQAIVDAYGVANYREINPAPYTIITFPFLFAVMFGDAGHGTLMALFGLWMILKEAKLIAAKSTNEMWTVIFGGRYIIFFMGLFSIYTGFLYNDFFSKSVNVFGSSWNVSGMVNFTEDLLDQNIKLQLDPVQTYSGDPYPYGFDPIWQLSENKLNFLNPFKMRISIIFGVTHMMFGIFLSFFNYMSRREYSRIFLEFIPQVLFLGLIFGYLVSLIFFKWLAYDASTSKSAPSIINIFIFMFMVSNKPELYMYSGQFYVQVVLLVVAVLCVPIMLFGNPIYLLIKHSLKKNTFQPKMRFSTLLMQRLNRQEDSMGIAINDSLDEQFQTESSSQGNSLEGSLEEDGVGTRTKEEFDFGELMIRQAIHTIEFCLGCVSNTASYLRLWALSLAHAELSEVLWTMVMHNGLALTLLPVSFGWVALVPVFVAFADMTAAILLLMEGLSAFLHALRLHWVEFQNKFYKGEGYLFVPFSFAKILEAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPD1</accession>
    <name>A0A914BPD1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein POC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein of centriole 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077561.1">
        <property type="nucleotide sequence ID" value="XM_038221633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPD1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221633.1">
        <property type="protein sequence ID" value="XP_038077561.1"/>
        <property type="gene ID" value="LOC119745341"/>
    </dbReference>
    <dbReference type="GeneID" id="119745341"/>
    <dbReference type="OMA" id="CKMGLFE"/>
    <dbReference type="OrthoDB" id="10064898at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033351">
        <property type="entry name" value="POC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="542"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="608" mass="67739" checksum="36E6744D9BF5873E" modified="2023-02-22" version="1">MMQLPSYELFVSVPDATSDSNQPGQPTHMRLCCIMSSTEDDSSVPILPSDSPGSSVSTTLQDEYQELLKYAVVAPNYDPTNLPQSLAQAVHAFSNRPRRDELIFEDSSVTSTPEKSASADTSRDKESEQALQGSNSEVESDYRLEQTGADEITPVRPSLLAAATPETPETDESSVSDTYTSRSSVMSPSIDQDLAKMEANLDNWCLDMKRNILAEMSQSKISLIERHRQEIRAIKDRHNKEVNQLQNEIENLKELLHTYEVSIERKDGVVSNLTRALQRQKERFEMLKRFQAWKLRHTEDRREAFTSKLAVRQRERHLMTKVWGAWHSVIEAKWKQRVEKACQSKAQEVCMSLTNDYETRLASLNEALESSRAEVTRLHSEREMYEETMKKAFMRGVCALNLEAMTMFHENEENDGGRCDSDNAATHQPSSATLSIPTPTQTVTNTKTTSQPRTVTSQSATTPGTLTQSVGGSMNRVTTTRTTHRYKPPKTITARISTRPDSGKMGQQTEATLAPPMSSVMVERHHPIIQQTIGHALASKYPQATGETSHGSTGARQPLLGNSHSNKQQLSGQISQQSAGVAKRKIPGQSGRAMLAESPNIHTVKVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPG0</accession>
    <name>A0A914BPG0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078163.1">
        <property type="nucleotide sequence ID" value="XM_038222235.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222235.1">
        <property type="protein sequence ID" value="XP_038078163.1"/>
        <property type="gene ID" value="LOC119745697"/>
    </dbReference>
    <dbReference type="GeneID" id="119745697"/>
    <dbReference type="OMA" id="GTQKMKK"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20538">
        <property type="entry name" value="CYCLIN_CCNT_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20539">
        <property type="entry name" value="CYCLIN_CCNT_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000004">
        <property type="entry name" value="Cyclin T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000009">
        <property type="entry name" value="cyclin-T2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="14">
        <location>
            <begin position="154"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1446"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="755"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="802"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1221"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1240"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1315"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1359"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1411"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165438" checksum="549E4EBF9DEC1910" modified="2023-02-22" version="1">MAAIPDRERRWYFTRDVLMNSPSRKCQIEPEKELSYRQQAANLIQDMGQRLQVNQLCINTAIVYMHRFYVFHSFSRFPRNSIAAAALFLAAKVEEQPHKLEYVIKVHHACLHRGSPVLDTKSDAYLQQAQELVINESILLQTLGFEVAVDHPHTHVVKCTQMIRASKDLAQTSYFMATNSLHLTTFCLQYRPTVVACVCIYLVAKWSQWEIMKSSDGKDWWEYVDPTVTKELLDELTKEFLRIFDACPSRLKRRISNEKITSQSRKRPKESFSESHSASTAKSVPSSSASVSSVDSGLPGSGNSESSVNTQELIATTSSQGDSLSLSQDNSHTEGDKLGLHEINMGLPMMEASMFPLESEYMSGVSFNPGAEIKHGPPSTQSDADQGKPMDQQGHPVKKSLKEYREQKERERMKNAQSREKAPPRPSHTASRPGAVSNQNLHTPKVNVDASHTDQRHREGYHSQGGQKHRPEDRHLPVEHRRAEKASGVRQEQSGSHPQSKSSGRPTDLRPTRDQRPLSQHRPHDSGSQPSQASVTDSRYSKSLDQYHKHSRDSVPHSSDRKQHLGPGEQGKEHKRNGFENREHSANLRLPEAHQRLLSSAPPTKPHATASQRPHTETLNAHSSEKMPTSELHGKPHPETLRPSKSEMYRSHRPEHQGNLKSEKHRTPSSETVKLQKSQSLKPHRSEIPKGTSTEKERTQPAIPPLVPAVDTKREQRSAPTVETQRVEPPQPIYQELPRPQRPERVLLQQPQTLKVDRRVTQTPNKHDSLKVRKTEDQVLHRSDTVILSKTEVPSTKSAGVSKEKDPEATKSLKSDVLSKPHKTEESRLPRAETHNTQRVEIPKPQTTDMARRKEPEVPQTQKPQQLKVVKAEPQQPGNPTVQTRTEKLDVSKTQKVVQSQPHRPETPKKQRVKQEQGQPQKAPPPKSQPPQAIPGKLLEKDSGITTTKLLTNKSQKLQTPVVQKTSIKSEVPDVSVPSKLATRKKPLTPPTSKQEAPTPEKPVTVSSQKLVANKSKQPEMSTSGNPDKAPSQRSETVILQKTDTQSKPPTPKPQRSTTPRSRVSPGAAAEQVPKPSRKVETPKLPKADTGGASVSKVVWEPAKPLEVLKPAVSDEVADSESVDADIDKLINAHMAEQSIKQGLEVPPILDLKPTLPLPNTTESREQKRERDESNLPKSYREKESHHRKKRSEGHKSRGSPHKHRHSSDHRKGSRVDAEGQPSSAEKQANASEGIDDSQPHSSILTTSSGIRLKIKGLSNSMNSGSGKHEPSPEPSRQTSSPGLVMKLNLSKMQASHTNSDHQPESSAGSEKSSGHHRRHRHHHRHKHGHHKHHRSESHHHGDDGRESHKRKRSHSRSDSVSSGGRDASPAMSSPAKKRTHSRASHSHPKSILPSEQSLLNLPMPPADPSSAYTGYDTHSSASTGQFSYGMRDFSHHAPLTTVTALPSSDGFEYYPYNQSSDGHAPPPPPPPREDLPPPPPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPV0</accession>
    <name>A0A914BPV0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078169.1">
        <property type="nucleotide sequence ID" value="XM_038222241.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078170.1">
        <property type="nucleotide sequence ID" value="XM_038222242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222241.1">
        <property type="protein sequence ID" value="XP_038078169.1"/>
        <property type="gene ID" value="LOC119745702"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222242.1">
        <property type="protein sequence ID" value="XP_038078170.1"/>
        <property type="gene ID" value="LOC119745702"/>
    </dbReference>
    <dbReference type="GeneID" id="119745702"/>
    <dbReference type="OMA" id="WEEERIS"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="158"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="38912" checksum="1F491F3D043017CA" modified="2023-02-22" version="1">MPSAKATRQGNEAGPQGASGSRPAQPAGQSLKQLGKRSKKNKAKKAAKKKKKMRLPTRLTRLLNYKAKRVHLDGLKSQSVNQKLCEGSTTLIRHCNRTLSSTTSGGGVKGFLEEGRGSCLSAFQKASNFAHRASDSSGDLGSKDGEGSAGWRLIPKEKLIALDCEMVGVGPQGRTSALGRCSIVDYDCNVLYDDYVKPEVEILHYRTQWSGIRKRHMVDAIPFREAQQQIADILRGKVLIGHSLRSDIQVLQLGHPREDTRDTSTYRGLRELAGVTVGPGQQLGLKKLTKLLFGHSIQQGEHCSVEDARATMNLYKLVERQWEAERVSAFPDRDFRVSFMDDHFWPDDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ22</accession>
    <name>A0A914BQ22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077592.1">
        <property type="nucleotide sequence ID" value="XM_038221664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221664.1">
        <property type="protein sequence ID" value="XP_038077592.1"/>
        <property type="gene ID" value="LOC119745358"/>
    </dbReference>
    <dbReference type="GeneID" id="119745358"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="128"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="26648" checksum="0DB362872C973BBF" modified="2023-02-22" version="1">GNSVKLRASVTGPVPSDGDGPASQVCQQCCLGPAAIPGIPGLPGPAGPMGPYGQPGSKGDAGQQGEIGPIGPIEPGERGAPGNSGSKGNNGIGLPGKIGPRGLPGFVGGTGETGVKGQKGEPGETPDDSKQRVAFTVVRTSNSDTSRSHDTRLPFQQTETLLPGTTFDLETGTFTCSVAGTYVFTFSSLEYSHSDSFSIHLVKNDYKVISTYGHSNQRGQLSGSAVMVLQRGDSVYLTMYGRAQGSSTYHYTSFSGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRR2</accession>
    <name>A0A914BRR2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc transporter ZIP9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078993.1">
        <property type="nucleotide sequence ID" value="XM_038223065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223065.1">
        <property type="protein sequence ID" value="XP_038078993.1"/>
        <property type="gene ID" value="LOC119746237"/>
    </dbReference>
    <dbReference type="GeneID" id="119746237"/>
    <dbReference type="CTD" id="55334"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34144" checksum="945055BA34B964B3" modified="2023-02-22" version="1">MEDAWGILALSFAMLIGCYIAGTIPLTVPLSESKMRFVTVLGAGLLVGTALAVIIPEGVHTLFAGTTQESHVHVVNPPAVGAENQAGGQPADGNPHEANGEAHAHTHSTHNEAELHYVIGVSLVLGFVFMLLVDQIGGAHGHSHAQITTGEGENASRTTRIGFTATLGLVVHAAADGVAMGAAAMGRTDVQMIVFIAIMLHKAPAAFGLVTFLLHENYQRNRIRRHLVVFSMAAPVAALVTYFGLSHASKEALSTFNATGISMLFSAGTFLYVATVHVLPEIAGLRRVSSDVEGSTEMTSGFSRLELLAVVSGCLAPLVLSLGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRU5</accession>
    <name>A0A914BRU5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 15 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078685.1">
        <property type="nucleotide sequence ID" value="XM_038222757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRU5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222757.1">
        <property type="protein sequence ID" value="XP_038078685.1"/>
        <property type="gene ID" value="LOC119746006"/>
    </dbReference>
    <dbReference type="GeneID" id="119746006"/>
    <dbReference type="CTD" id="84135"/>
    <dbReference type="OMA" id="ATYQVVH"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="10">
        <location>
            <begin position="350"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="59600" checksum="352D6CA66651F411" modified="2023-02-22" version="1">MASDYKRVVVKTFPSGDADVSKETQYWKNFEFPVTVKEFGAVTCIDFNPRKPHQFAVTSSTRVQIFDPVTNQVEKTISRFQDVAYSGTYRADGKLLVAGGEEKSIRLFDVSGKAVLRIFKGHNGPVHVTKFSTDNHHVMSCSDDKSVRCWDIPSETETRRYEEHTDYVRCGTVSAASKDIWLTGSYDHKVKLFDLRTQASVMTLDHGHPVESVLMFPGGGMFLSSGGNYVKVWDALAGGKLLAAVSNHHKTITCMCFNGAHNRLLTASIDRHVKVYDVASYKLVASLDYPAPILSMGVSPTDNTIVVGMSSGLVSIRHRKPETDESEKTRRKTKLSRVSHRYYDRGHKVYTAQKGDLLIHKTPREILQKYDAMLKRFEHSKALDAALTTNVRIRTPEVTVSILQELIRRGVVKSALSGRDEKWLRIMIAFLKKHITNPNYAATVIDITNMLLDIYTPVIGDSDELVSHFRRLKITLDKELQYHRTLLEIKGMLDTVLAASQSVDADAQEDSAEVEIPTERTESGGIPVAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS93</accession>
    <name>A0A914BS93_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038078835.1">
        <property type="nucleotide sequence ID" value="XM_038222907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222907.1">
        <property type="protein sequence ID" value="XP_038078835.1"/>
        <property type="gene ID" value="LOC119746113"/>
    </dbReference>
    <dbReference type="GeneID" id="119746113"/>
    <dbReference type="OMA" id="HWRENGF"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37811" checksum="45AF4E1BEC0541EC" modified="2023-02-22" version="1">MSETIVSDDLEELTQQLLDHHNAKSSTQKEGEKPQQLLDEVSFEGVARYIKSGRCKNIIVMSGAGISTSAGLPDFRSKNTGLYNSLQKYNLASPHLMFEIRYFKERPEPFCTLAKALYPGVFKPTPCHYFIRLLGEKNLLLRDYTQNVDTLDVIAGVPEELLVEIHGSFSTAHCIDKSCHKEHSSKWVKDEIFADRIPKCDDCGALIKPDISFFGEVPVKKWHDTPKEDFPKCDLLIVMGTTLIVQPFTSLINTVPATTPRLLINYEMSGKCDPLMKFSGQPTGFNFGYEDNYRDVAFLGTCDEGCSKLADLLGWKDELEQLIKTEHEKLDAEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTD0</accession>
    <name>A0A914BTD0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079250.1">
        <property type="nucleotide sequence ID" value="XM_038223322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223322.1">
        <property type="protein sequence ID" value="XP_038079250.1"/>
        <property type="gene ID" value="LOC119746401"/>
    </dbReference>
    <dbReference type="GeneID" id="119746401"/>
    <dbReference type="OMA" id="WCLLIVE"/>
    <dbReference type="OrthoDB" id="6120134at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037250656" description="SUEL-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="33835" checksum="F341C825AB482D15" modified="2023-02-22" version="1">MSVSGMCRIGALVVLLTLVVRAQASHYLGPPVITKTACQGTRLNIDCPAGQGLNIKSANYGRLPGKTACGSYGLSGCYTPNALLAVRAKCQGKSWCKVPANKGFFGGKCEGSGQYLQVSYTCDYPIMRTKFACQDSTLNIDCKKGHHIAIDHALFGRVHGNAVCPTDPYWLKSVHCVSGAGLKIVKRKCHSKRWCKVRASVDLFGDPCPGTHKYLFVRYSCTLSTDSNSNPGSNSSGRSSSGGSGSNSSSGGSSSGGSGSNSSSGGSSSGGSGSKSSSGGSSSGGSGSNSSGGRSSSGGSGSGSNSSGGRSSSSGSGSGSNSSGGGSGSGSGGSSSGHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXA0</accession>
    <name>A0A913YXA0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044161.1">
        <property type="nucleotide sequence ID" value="XM_038188233.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044162.1">
        <property type="nucleotide sequence ID" value="XM_038188234.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044163.1">
        <property type="nucleotide sequence ID" value="XM_038188235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188233.1">
        <property type="protein sequence ID" value="XP_038044161.1"/>
        <property type="gene ID" value="LOC119718814"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188234.1">
        <property type="protein sequence ID" value="XP_038044162.1"/>
        <property type="gene ID" value="LOC119718814"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188235.1">
        <property type="protein sequence ID" value="XP_038044163.1"/>
        <property type="gene ID" value="LOC119718814"/>
    </dbReference>
    <dbReference type="GeneID" id="119718814"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="79" mass="8696" checksum="4CB5D53942EB110A" modified="2023-02-22" version="1">MLQRNVGEISPCLKQQRKNHSGMACELQPIKPSPVLESYRNKCEFTIGKSVYGIDNTVGSGLAHTKVSISSEVSFLQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZ47</accession>
    <name>A0A913YZ47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044838.1">
        <property type="nucleotide sequence ID" value="XM_038188910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZ47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188910.1">
        <property type="protein sequence ID" value="XP_038044838.1"/>
        <property type="gene ID" value="LOC119719450"/>
    </dbReference>
    <dbReference type="GeneID" id="119719450"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="248"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="407"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="571"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="731"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="880" mass="97462" checksum="165498F4424160BF" modified="2023-02-22" version="1">METIGTAVETLDNPGKLVPFLKDLGARHNAYGTKPEHFKPLAEALIFTLKDGLPPKVFTAEVQGAWENALKVVAELMSEAMRSDDADVGPMSQRDKRLVRECWKVIQKDMVNLGAALFVRLLEKSPPIQNLFTFGKLNLSAEKLKRNKDLRSHGQRVMSTIGAVVMGLDDPDIIATILEDLGARHQMYGAKPEHFPALVEALMHSLKNGLPPKLFTPEAQEAWQNLMKMVATSMSKTMRSGSSEDEGPISSKNKRLVQASWKIMEKDAVNLGAVLFARLLEKNPSIQKLFPFGKLNLPPDKLRQNPDLRAHGKGVMETIGILVASLDDLKDIVPTLKELGARHNSYGAKPEHFPALVEAFMFSMKTRVSAEVFTAEVQEAWRNVLKVVDVTMSTSMSSHSNGASDVTISPKDKQLAQGSWKFIQKDLVNLGASMFVRLLEKNPGIRKTFSFGRLNLPPDKLRQNPDLRAHGKGVMLTFGTLVSGADDLGKIIPMMEDLGARHKTYGAKPAHFPAIVEAFMYSLKKGLSPKIFTPDVQEAWRNILSVVAVTMGSTMSSDESGVSEEESTASPISPKDKQLVQNSWKFVQKDLVNLGAVMFVRLLEKNPSVQNLFSFGKLNLPPEKLKQNPDLRAHGKGVMETIGTAVAGLDDLGRIVPILEEVGARHKIYGARPEHFPAVVEALMYSLKQGLSPNVFTSETQEAWRNILKVVDVTMSRTMRLDENGNSEEGLISLRDKRLVQKSWKVMQKDSVNLGAALFARFLDRNPSIRELFPFGKSSVPPQMLKHNSDLRAHGKGVMETIGTAVDGLDDLGKIVPILKDLGTRHNVYGAKPEHFQPLVDAFMYTMRNGLSSKEFTPDVQDAWENIWKVLAEVMSNGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z106</accession>
    <name>A0A913Z106_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044350.1">
        <property type="nucleotide sequence ID" value="XM_038188422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z106"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188422.1">
        <property type="protein sequence ID" value="XP_038044350.1"/>
        <property type="gene ID" value="LOC119719106"/>
    </dbReference>
    <dbReference type="GeneID" id="119719106"/>
    <dbReference type="OMA" id="QNFREST"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="34913" checksum="661CC0443E97A50A" modified="2023-02-22" version="1">MSDMENPVRVIVWATPRTRSSILLKSLSNLPDSQAIFEIYTTAYYNGPERVDVRFEEQVSAGEEASEDGLFKGHRSGFPSSLCSYDWARRQLEADYPGKAVIVAKELAPWLRGRYKDIPRGYRHVFLIRHPTEMFPSWKKLNREFLELQRGVKVDMEDFDLDQLTPDVLPPGLTYKEIFDLWQYVRDSNLDPDPVIVDSDDLVCNPARVLSSLCEHLGIPYTDSLLSWQQGTECVKDWLAGSLVKQVLETMAHFQNFRESTCFLKPETVGKVSNVASLSPDLQRCINFSMPYYATMYEQRLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3I0</accession>
    <name>A0A913Z3I0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045265.1">
        <property type="nucleotide sequence ID" value="XM_038189337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3I0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189337.1">
        <property type="protein sequence ID" value="XP_038045265.1"/>
        <property type="gene ID" value="LOC119719841"/>
    </dbReference>
    <dbReference type="GeneID" id="119719841"/>
    <dbReference type="OrthoDB" id="10447984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="18537" checksum="329029A6C25084AD" modified="2023-02-22" version="1">MSTRAIYKSGVNAPQRIKQKSSSFTQVGCITERASVRSRLHTGLRRLACSSRTRFIAQKARKIASTFSSDKGGIVPVTKVVTMRPHVLLFTCLAVPCLLLAQMVSSVPIFDGDNQLRALDIGDWPVDAYGDTQYLHGAEKRVRPRGGEYCVDWIHNTWRRCKGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3U2</accession>
    <name>A0A913Z3U2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045380.1">
        <property type="nucleotide sequence ID" value="XM_038189452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3U2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189452.1">
        <property type="protein sequence ID" value="XP_038045380.1"/>
        <property type="gene ID" value="LOC119719967"/>
    </dbReference>
    <dbReference type="GeneID" id="119719967"/>
    <dbReference type="OrthoDB" id="9889709at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037778761" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="155"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="291" mass="29778" checksum="95AAE76B5D395FF5" modified="2023-02-22" version="1">MKIGVATVIAVALFLGNSVELRAAVTTGPIPSDGDGPATEACQTSCQGTAAIVGMLQGLKGDAGRPGEKGDIGPYGPLGERGAPGVRGQMGNSGPPGSKGDAGESGQRGEIGPIGLKGDTGPKGDDAIGLPGLVGATGRTGVKGQKGEPGETPENSNQRVAFTAVRTSNAFTSTSHNTRLPFEEFETLLPGTNFDLENGTFTCGVPGTYVFTFSVLKNGPSSVMYVFLVKNGTFVVSGLSNDGNHYEQVSGSAVLVLQRGDTVYLTMNGGPVYSEPVAHYTSFSGFLLYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z402</accession>
    <name>A0A913Z402_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046524.1">
        <property type="nucleotide sequence ID" value="XM_038190596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z402"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190596.1">
        <property type="protein sequence ID" value="XP_038046524.1"/>
        <property type="gene ID" value="LOC119720762"/>
    </dbReference>
    <dbReference type="GeneID" id="119720762"/>
    <dbReference type="OMA" id="VEWRTSP"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="359" mass="40959" checksum="AEA157AC8BA9EE6F" modified="2023-02-22" version="1">MAGTVLIETFMNASTESPGPIYAHWYPEVARIVLVTTSFLTIVANLLVLIVFQYMKALENMTGVFVKSLAVADLGVGVCVFAAVQSQWAEKWPHGTGMWSCKLMGYIMAMMVGGSILSLTCVSIDRYIAVIKPLKYRSIVTKRRARVYAVVVWVFVALIFLPSMFGWGGYVFEEYSDDCKKHFNQSLSMSFYIICILIVPAILISIYCYFHILRACLAQTRQMERLETLFHDGESQQDATSRIYEKMLAKIFLIVIGAFYLSWIPFVIKKIIELAIDVSIHPAVSFFTAWLGFLNSFLNCIIYIICHRSFREGLHLLLKAMWQGITSVCKISKDRCFSQRRERSQSQVMQLREFSTTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5K4</accession>
    <name>A0A913Z5K4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046060.1">
        <property type="nucleotide sequence ID" value="XM_038190132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5K4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190132.1">
        <property type="protein sequence ID" value="XP_038046060.1"/>
        <property type="gene ID" value="LOC119720460"/>
    </dbReference>
    <dbReference type="GeneID" id="119720460"/>
    <dbReference type="OMA" id="GCMASET"/>
    <dbReference type="OrthoDB" id="10198353at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="63392" checksum="4B3B7D6F1DF4A6BC" modified="2023-02-22" version="1">MGTTLEPTTTPGPTTIPGPTTTPGPTSTPGLTTIPGPTNPQGPTTIPGPTTTPGPTTTQRPTNPPGPTTIPGPTTIPGPTSIPGPTNPPGPTTIPVPTTAVGPTTTPGPTNPPGPTTIPGPTTSPGPTTTEVSTTCAPPTVNVPTVGPQCLAVGATTLSVTWTTVTAINAGGGSITCTDSGDGTGLTTSAGTFGAGSHTITCSVTNVEGCFGSNSFTFLVSAVSPKCAYVGASTASVTWPVVTATNAAGGSISCSDSEDGTSLTPTGGTFGVGSHTVTCTVTNSGSCTGSNSFTFAVAASPSVTVPSVGPHCADESSSTATVTWTTVTATNTEGESITCTDSGDGTGVTISGGTFGVGSHTITCSVTNTNSCSGSNSFTFVVSASPSISVPVVPVSCTDPNQVTTRVLWSTVTGTNTNGQIIQCTSGALSVFLVGGNFPLGTHTVTCTVTNSGGCMASETFAVAVVASPSLTVPDVDDQCTDFGLATATVSWPAVSGTDLGGQAIICTEGAIAVPLSGGIAFGVGVHIVTCQVTINNGCEDSKSFSFTVQQSPILNLPVVDNRCAVSWWVYAQVSWPLVTATHSDNNQIVCIAWGISMPLTGGWWYLQDYTHVHTCVVTNNAGCTAVGAFDFHVFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7E7</accession>
    <name>A0A913Z7E7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046936.1">
        <property type="nucleotide sequence ID" value="XM_038191008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7E7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191008.1">
        <property type="protein sequence ID" value="XP_038046936.1"/>
        <property type="gene ID" value="LOC119721113"/>
    </dbReference>
    <dbReference type="GeneID" id="119721113"/>
    <dbReference type="OrthoDB" id="10206983at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="143" mass="16134" checksum="4D539D321CD35400" modified="2023-02-22" version="1">MKMPSAAAVKKKLKRIDVHIQGEDFKLRGLVPFHASVIKPKPSVGKISYIRVPSAHRSKEVESHVAFPKPASPYIAARKRAQRRGVTARRIRKRRRRRKRKLGCQIFQTTCASRLGFCQLPADQTCSTAESSNMVNVNEKLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8Y7</accession>
    <name>A0A913Z8Y7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047476.1">
        <property type="nucleotide sequence ID" value="XM_038191548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8Y7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191548.1">
        <property type="protein sequence ID" value="XP_038047476.1"/>
        <property type="gene ID" value="LOC119721466"/>
    </dbReference>
    <dbReference type="GeneID" id="119721466"/>
    <dbReference type="OMA" id="HHECSKD"/>
    <dbReference type="OrthoDB" id="10004661at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF9">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 middle" evidence="2">
        <location>
            <begin position="426"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="3">
        <location>
            <begin position="515"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="74247" checksum="187C1AAFC3D9937E" modified="2023-02-22" version="1">MDHSTPQLNSLIIKMAVKWNFRCACWGFISSLLASVLLNCCFSPQSHLAFRVIAGAAAVLIGISSLIAFHISTLRCSESHTLITLLMSYKWHQGERLSTPSILAKATDMWKRPREAQEDLIRELTRRHAKTEYGRKNRLWEIRSVEDLRKKHPLTTYDHYSDYIQRLADGEEGVFLDEDPMRFGVTSGTTGAGKKIPLVSFGLEGDALCSQIKRLALYQGAQRPSPVQKRCFVYIHPKISLTKTGRVISPYMFIKQEDTKRLSELSSPPPAFTITNEPSAAYVHMLFAIADTNLALLSTVLTPQMYRALKCLEAKWQVMLEDLSTGQINAKIPLDPDTRRSLQGYLRPNKARVSQLRSEFEKGFHGILKRIWPHLIAIEAIDIAGFKKKIEETYTDGVPYFNWAYGGTEVGQLAINMWLHDKEVRYAICPHMAVVEFIPEQNSSDEDPKTLLIDEVEVGGRYELVLTTRSGLYRYRNGDVIQIVGFHENCPAMRMLYRSGEYLNLVYEKVNTQVVDAAIKNTIQGWPGIQLVDWTCAESPVYDPESSELYYIVFLEVDPGKRELNDVTAEQMSKFDEHLQQDHVYYSGLRESNTISPSRVKFVRPGTFLELRDFRVNKTTASVMQYKTPRKLRTREHVIWLMERVIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z970</accession>
    <name>A0A913Z970_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048323.1">
        <property type="nucleotide sequence ID" value="XM_038192395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z970"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192395.1">
        <property type="protein sequence ID" value="XP_038048323.1"/>
        <property type="gene ID" value="LOC119722339"/>
    </dbReference>
    <dbReference type="GeneID" id="119722339"/>
    <dbReference type="OMA" id="EFNLHIG"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="75"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="37645" checksum="06E5579DB1B4658B" modified="2023-02-22" version="1">MASHVILTIFVHVFAAFSLIFCPLILSLGWLLPVEWCFWIAVTLLSASVSALWMYRLQQPNDSQLEAFFGDSWPNRAVCHRGAAGDAPENTLVAFREARKNGATFVEFDVALTKDKAPVIFHDDTVDRTTDATGALKDLTLDEVLKLNAAAKDPLRDKFPHASIPTLEEATVECLGLGMNIFFDVKDWSTEMVNALTALFQRHTELYQKGMVCSFFPMLSYKIRRQDPAILTALTTCTTTVQYGFGCDVTGPIWKRYPCILADYLLVWCQSAWLWILCGNAATLLDKKIVTEGTVDYWAQRGIKTVVWTVNDNTEKEYFHKCLKCGIITDNVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9R5</accession>
    <name>A0A913Z9R5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047625.1">
        <property type="nucleotide sequence ID" value="XM_038191697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9R5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191697.1">
        <property type="protein sequence ID" value="XP_038047625.1"/>
        <property type="gene ID" value="LOC119721730"/>
    </dbReference>
    <dbReference type="GeneID" id="119721730"/>
    <dbReference type="OrthoDB" id="6132274at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="YqaJ viral recombinase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="248" mass="27763" checksum="923C19DF0CBB10A6" modified="2023-02-22" version="1">MAVNNKVVEPSRRKGARTTPLVEGLVKGGPSLSHLPAKAWGCKHEQDAVNAFKSQETVNHVNLSVEQAGLFVKGSLSYIGATLDAVVRCECHGSAPLECKCPYSVRDQTIQDSFKKTDFLEQAESGEMRLKRNHTYFYQIQAQIAVTDTKFGYFCVWTGNGPTFVEVIEAAPEWWKKVEQNLMFFFKAYVSQYLEGLRCSHTAQHIPRCVSKKMKSKGMLNLVCVVIHATFGYIGNVHYIQCALCLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB63</accession>
    <name>A0A913ZB63_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048814.1">
        <property type="nucleotide sequence ID" value="XM_038192886.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192886.1">
        <property type="protein sequence ID" value="XP_038048814.1"/>
        <property type="gene ID" value="LOC119722655"/>
    </dbReference>
    <dbReference type="GeneID" id="119722655"/>
    <dbReference type="OMA" id="MQYICEI"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037033738" evidence="4">
        <location>
            <begin position="25"/>
            <end position="3473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="3322"/>
            <end position="3342"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="147"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="392"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="505"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="628"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="757"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="863"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1315"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1577"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1693"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1807"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="1932"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="2056"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="2161"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="2291"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="2394"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="2524"/>
            <end position="2615"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="2628"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="2756"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="2858"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="2986"/>
            <end position="3077"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="3080"/>
            <end position="3190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="3080"/>
            <end position="3107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3473" mass="387061" checksum="C9644048D9371F4F" modified="2023-02-22" version="1">MGRLILPGVLLCVLLHISTPATTACYVPVDLSGPSGNASSLEHPDPYPWDYDCQLFTITVDDDKIIRLMFDSFDLGDDDVLMISEPNKVDPLILRAGRLPKNYYSSGNTVQLNFTSESYNADNRTGFLAYYTESDRVIPELKQLVQSYNLIPGKPTVIRSLDYPQSYRDLVLYFFTFTSTPNTRIWAEIMDLDTEEGLDFIEMGNGVNASQRFETRLARVSGRRGRYQPVVSESNEMWLLFESDYSVTGRGFSVMLYETSMGLPDAKNETAMPANVTCGENITIPESGSTSVSLSNYDNDLLCIWKVSGVAGLRIRMTPDNFSLEYGFDVLEIGSGSDPMDQSSRFISLTGDNLSGPMMLESDAVWLRFRSDATTSDQGFSITFDQPTTNDCGGEFYINDTNPSITVAVDGTDLPSSQCQWVIHGRPGRFISGNTINFNTEDVYDVVEIGTGDNPADPKTRIKMIAGSMEEGMFYTTSDTVWVTFTVNGGQAGQGFNMSFTDDACGITTLLDRQGTIQSPGYPVSYPSDADCQWIIQVRGGYNIKLTVTDLSTEYGHDKLLIGGVEPQDSGWSPYYELTGEMESAQVMSQYNGLSLRLISDGSMQYGGFSATYEETFSCPEGYVLGNNGSACYKFVLSPSTWEEARDECLNVADGDLLVINDQAEFEYIQEMATNITGDWWVGWYDLAIEGQWSWVDCQASTSWANSRWANSSSGDAAMEEDCGMLLGDSGLLDDRNCSIPMKFVCETTKKDYTDASPSLIRGRATSSSSILLSWRVSSIICDLRGYQIRYNTTAAMDQFNYIDVMDPQASSVEVTGLMPQTTYLFEFVFDTFSDGLSSYRTAKSIFASTEESPCPEGFEPGYADNCYKFVKKLVTYEDARADCQRTPGGDLVIINDVSEQQYIQNRSVDGDWWIGLNDRAVEGRFRWPDCSPLTIWQSRQWAPDQPNDLTGSQDCGQLLETGQWNDWQCDRPMQYICEIITKNFEPEEVRPRFFTAVEVTPYSIRLSWLPPVNDCDIKGYTIMWRRVGDAPMMAPIEGVETTELIVDNLIPEETYSFQIAAETFRQTLPFSSPRNVTLSPGTGFCPGDYEIGLNDTCYKFVKRLVTWDEARMDCRSFRNGDLVIIDDVIEHEYIMERIVDGDWWIGFSDRGTEGRWQSVNCTDLTPWQASNWAPDQPNDLSGTQDCGQLLETGQWNDWQCDRPMQYICEIAPRVFNPEDQVATNLTLEEVTSSSVTVSWMPPSYSCDVLGYRITYTISLSIYTLDVEGGDTSQVTVSGLRPLSRYSFTLQTKMAMGNSEPSEPVIANTAAFEGCEDAILRTDAVGNITSPLFPDNYPRLVNCLYRIDLSASVGADARIRLRFVTFSLGADDYIEIRELDSTSRNNGIPTIVKGRGPVKDYFSSGNSLEIEFVSDTTAEARGFRILYSLSDEVQPAVKDCGMTYTVKTNTLLGFESVGYPNRYDNYQDCTWFFTCSPGKVMFAYLRKAGLEDGYDWLVVGDGGDPMNETSVLQQVTGKAEEISLFSEDNMMWMTFNSDYSNSGNGFSFLVEEIDPTEVSGPPPKVQRSGDVGIQSTCGGDILVPNDGQAIITSPNYPDDYDSNTTCIWLITGVPGRRFQMSFTYFNTEKSYDYLTVGSGLDPSDVTSLRTAASGSSLPSDIVLASDTAWVLFASDSSINAGGFSISIQNGNDCEVILTVPAGGNVTVMSPNYPSDYPSNSYCFWTIVGQSGQALRADIVSFSTEDGYDFVDVGVGNQPANLSTRFIHTSGTGVQPFSAESSTLWMTFTSDGTNNDGGFEVVFYDDSCDDTVIENTTSGRIESLNFPNTYPNNLDCVWTIRVGDIFRVKLMFEAFDVEAGFDKLIIDGVQGGSTLTLTGSDLPDDIVSETNEITIRFQTDSDGGTSGFALMFEETYYCPDGYVAFPVGEAYTCYRFSTEEKNWLEARKDCQTTDNGDLIIIENALENRGIAEITGGLDWWLGFYDRANEGIWRWVDCQAPTAWGTANWDDPSGPDNANGDEDCAIILDTSGRYQAIPCETPRRYICEIGQPKNFDGNPVRLSGFSYSTSSIHLEWVLSPQRCDVLSYFIQYSTASGSPEEAFVTGSNTNELDVFELVRDTSYFFSISAVTFTSGKLPYSDPVEIKTLQFDNEYCPPGWQGGWEYQCYKIVLDPVTWDEARADCRSVENGDLVDINFYAELQYINQTAPGETLWIGYYDKGIEGDWRWSDCELPNAWQAINWAPDSPNDPLGNQDCAEMTPDLLWNDQPCNGNVRNGYVCEIYTKNYADTDQNPSNLTGQALTATRVYLTWPISVRFVCDVLGYKIQYWFDDEDPKIQRVDGASTNRAVVEGLVPNKNYTFYISAYSSLGDVTPTAYVNVVTPDGDLCPSGYQEGYDYGCYKFVSDMKAWNEARTDCLSTQDGDLLIIDSQAELDYISQVKENITGTWWIGFYDTAEEGAWRWVDCSTPSGLNGTYWAIGQPSDTDGTENCAELTQNSKFNDIACSNQLMYVCEITRKEFFPSDVDPSNLEGLSTTSESVLLRWTVSDYNCDIQGYKVLYSVDQGAEQEQVVPGSNTNNVNITGLLPDTLYNFKLLAYTAFSDREVTAITTVTTLQIDNPCPEDGWELGNGGKCYKFVERFETWYDARAVCKQDADGDLVIIETQEENLYIQDRTQGGDWWIGFYDVSVEGDWRWVDCSTPSPWTASNWGADQPNNLNGNQHCGQILNDGKYNDWQCDRTMQFICEISPKPFDPSDGNPTRLRLAEDTPNSVLVRWRPSLVSCDVIGYRINYNDPIINGFTEVLGGNTSSVIISDLLDGFTYFFAIAAFTQEQLLPYSERVSIVTPSLDGLCEEGWEPGLDYKCYKFGIQQKTWEEARADCQSVTDGDLVIVETQEEHSYLVNRTLGGDWWIGFYDQGTEGDWRWVDCQAPGTWASGNWGSNQPNDLDDSQDCGQMLQTGLWNDWNCQRPMQYICEINPKAFTSEEQGPTLFRGRANDPVTIRLSWTPSEYNCEVRGYRIVYEEEKVGKTLTVEGGATSSVLLKSLSPGATYVFYIGAFTKDDELDLESRSVRIQLPQTGVCGETDWTASSGMIASPNYPDAYPAFQECVYTISLPDAAASVQIEFMDFDLEKGHDFLMMGPGLIPDVDIQYALTGSELPQMAMIDSSQVWMRFLSDESNQRSGFSLMYSAAEADMSGESVGSLTIVLISQSFKSFTEAVQTEFAIAVANQLNVYCKLAEDNCLVDATAEFTDKEVRFASLEDVAEGLQVTFWVIDPTDPMRRQAALTSSQLQSMLNEYGADVENDGQFQFVVRTESNPLSEPWVIALLCVLGFLVLILLVVIVKDLSSRRKKRPGSSLSSSDVEMKSRDDFMTTDDAELIANIDNESVSPDERRVPSSVTANVYYVNPVAASMNDEAEVSQDLGNTNDVPEVSDPKDEVIEVSDLKGEVNGNVEVEVEPEPLYATTTRESMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB65</accession>
    <name>A0A913ZB65_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048271.1">
        <property type="nucleotide sequence ID" value="XM_038192343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZB65"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192343.1">
        <property type="protein sequence ID" value="XP_038048271.1"/>
        <property type="gene ID" value="LOC119722299"/>
    </dbReference>
    <dbReference type="GeneID" id="119722299"/>
    <dbReference type="OMA" id="HESKSCL"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="286" mass="31751" checksum="291A44A679D7B13F" modified="2023-02-22" version="1">MPANAMAMASKASTPDSEVSAPPQENCYRLVVVGSPKVGKTAIVSRFLNGKFEDQYTPTIEDFHRKIYKIKGHVYQLDILDTSGNNPFPAIKKLSILTGDVFILVFSIDNKDSFGEVQRLRKQILETKCGNGAKSVPMVIAGNKCDREGSRQVNAEDARRAFESSKKCTFVETSAKRCHNIDVLFKALFENAKMPSEMSPSLHRKISASSSPALKPSSNGKLALRRRLSEACGMVSPNARRPSVRSDLLQLRSKVHRNSQDEDDDDDDDDRSSIQKKLRKIACCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCM3</accession>
    <name>A0A913ZCM3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048791.1">
        <property type="nucleotide sequence ID" value="XM_038192863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192863.1">
        <property type="protein sequence ID" value="XP_038048791.1"/>
        <property type="gene ID" value="LOC119722641"/>
    </dbReference>
    <dbReference type="GeneID" id="119722641"/>
    <dbReference type="OMA" id="APHVPHW"/>
    <dbReference type="OrthoDB" id="9993265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="306" mass="34492" checksum="44C31C8D55210A05" modified="2023-02-22" version="1">MTSANPATPLTRAEFKNACTSVLQGLECLARQRALIDDKLAESLQELGQVVNTLRPEIDNNKEYYVDGPLVRFLSANISKAKAIIQEIKRTCSERSANYHGIEYCKEHSRQHHQDIQSVLDALNDFYKHTVFRQDTQFIDNEVTRKMTPNKTRSANSRVTFADQLTAENGQTPLNTAAVTSASSERYTGRTGLASPSLEQPVQVWTAGSMGDTADPSTPGAFEHIRDMTRKDIHLENWPKDEKVPPTIMERTRPPLVHPGLRDVHNYRNLPQFTGINLPVKQVPVGELALPAPHVPHWDYHNNCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD15</accession>
    <name>A0A913ZD15_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049677.1">
        <property type="nucleotide sequence ID" value="XM_038193749.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193749.1">
        <property type="protein sequence ID" value="XP_038049677.1"/>
        <property type="gene ID" value="LOC119723189"/>
    </dbReference>
    <dbReference type="GeneID" id="119723189"/>
    <dbReference type="OMA" id="EAFITHV"/>
    <dbReference type="OrthoDB" id="7699516at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="509"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1061"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1401"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1290"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1482"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="168708" checksum="EEA2CDC0967BF542" modified="2023-02-22" version="1">MVERFNRTVKTMLSMFVDENQDDWDEHLPYVMMAYRSSQHDSTKFTPNMLMLCREVGLPLDVVVGLPKEQTAENAGENEDEFDSALRVLDRHFKPKLNVVAERYRFRRRSQLPGESVDDYIRELRALASSCNFGNMTDELIRDQFIERTYSTQIRERLLLEPDLTLTDAITISRQVESALRESKIIGENSSHTPEADVHAVTHRKPRQQNRKPRKHRNTTGHPPQQSRPAPLQSQICYRCGEQSHKANDPNCKAKYATCSKCGKIGHYARVCRSGQRFQSTRNQVQGVFTSDNPVAPHPDYQDSNVLTIQHIAHADSVKCSVLLGQSVQLAMTVDTGAAVSIIPASTFGKFFAREALQPSTAKLTTYLHEPSTVLGTFHTTVRLASNPERCVPAHIFVVQSGIAIMGLDLIRRLDITITGGKVMLVNGNDSKPPSSTPPAPTATTPSDQTSMDMRKQYPELFNGKVGLAKNYVHKVKVRPSVPPMQQKLRNLPFSVRDEVANELKRLEDADIIERIDASEWVSPLVVAYKKSGKVRLCVDLREVNKAVVVDKYPLPNIQELLGELHGASVFSSLDMNSAYHQLLLHEDSRDLEAFITHVGLFRFKRVCFGLASAPSAFQKLMSCALSGLAGVQCYLDDIVIFGRDQKDHDANLSAVLNRLTELGVTLNYDKCHFNLSNLRFLGHTVSSEGLTPDPTHVEALLNAPKPTDPSTLRSFMGLASYYARFVPNYASMVEPLRALLRKDTQFIWSEAAQSCFELLKQHISNATTLALFDPDLPTIVSTDASAYGIGAVLAQIKNNHEVPIAFASRSLTTTERKYSVSEREALACVWACEKWYKYLWGRQFTLRTDHQALTTLLSTRGTGHKPMRIARWAARLLNFNYTVEFRAGAHNRVADALSRLPLPTTVHATEHTDDEIIVQWISALLVDASAITKADLQSATRTDTILKSVSEYITSGWPAKQHITTELQPYFNLQDELSVADDCILRGDRFVIPTALQSSLITIAHQGHQGIVRTKQRLRDCYWWPGMGKQIEHQVRHCAACQVSDKTAYIRTPPLQPVPLPAHPWQKIAIDICGPFEHGPQNCRFAIVLMDYYSKWPEVAFAADATSHSVCSMLDSIFAREGLPNELVSDNGSQFVSTEFESYLIQRGIKHIRTSLYHPQANGLVERFNRVLKQTLQIATREHRPWKTATLELLTAYRSTAHATTGKSPAELLHSRRMTTTLNIRPTEISQEEPADIRDRVRSTQTKYKRYTDQKRGAVHPRFRTGDYVRVKNPRHVHKGSNRYGPPQRITQSKGPSTYQLEDGRTWNATHLTMTHKLPNQMPTTPRQPATPKPQNRPKRQLQRWWEGTFVVVRRINDVTYQIQRSPRAKAKVVDYNRLKQYLGDAKVDWWRRAAQGPLGVKDQASEAGLPTTLDRREVMLPDPTTTTNPDDPPADGGDQRWLQWFASTAEGPSAGTGVRTADIDSARPQVEAPEPSPDRRWRRRECRQSPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF34</accession>
    <name>A0A913ZF34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050069.1">
        <property type="nucleotide sequence ID" value="XM_038194141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194141.1">
        <property type="protein sequence ID" value="XP_038050069.1"/>
        <property type="gene ID" value="LOC119723471"/>
    </dbReference>
    <dbReference type="GeneID" id="119723471"/>
    <dbReference type="OMA" id="XELKEKM"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022082">
        <property type="entry name" value="Noelin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF87">
        <property type="entry name" value="AMASSIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12308">
        <property type="entry name" value="Noelin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036884601" description="Olfactomedin-like domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="12">
        <location>
            <begin position="260"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="537" mass="59999" checksum="C7070C1538EBE419" modified="2023-02-22" version="1">MTTFIVVLLFFTVGVSHGRVFEQEPVGFVTREPTFTKLLEPAENGFRVNGEMTDEGICLCTVQQPAEILCTDYQAKKNSEKLQDIQHKISKLAPDVKQLHETTTRHAELFAAFESNLTEVTSTFDLIEGGQMLVTRVEIEGVLTRIRHMQSTLFALREWHGIESEAAHMGKIQVMLDEASNITRIVDAMASEEFIDGAAAAIQREISSLTDRLKSCTDQATAGDRGSAGAERESPADSTTTPPTSDTLPELWPAKEKQNTCGRLVGISEPYTLRGSLGSKGTWMRDPILNPEFVYFHTFLATSSRSSSTTTQFKTSSSVKSFQRDETHQITGEVTHHIVESVVYNGSIFAYSSESTSRYSYYRDGHRQFKLIGINLSHTSPSFPAFTAGDVSQERAMTATQLEQASYRPTTVVPKMDLTVDETGLWLLYGDSLGMLTVSQVDQTTLEFNRTLRGAYPKNRLGNCFVVCGKVYCLNSYTEFDSKVSYFMDTETGFEGFTNVPFIIKYGSLSSIEYNPRDQMLYGWDNEHAVVYSMTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFG0</accession>
    <name>A0A913ZFG0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050189.1">
        <property type="nucleotide sequence ID" value="XM_038194261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFG0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194261.1">
        <property type="protein sequence ID" value="XP_038050189.1"/>
        <property type="gene ID" value="LOC119723552"/>
    </dbReference>
    <dbReference type="GeneID" id="119723552"/>
    <dbReference type="OMA" id="QNEMARG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF301">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="671" mass="73377" checksum="9D7BFCD295BE5263" modified="2023-02-22" version="1">MEKQKSNPLLCFLCNKTFKRPKILDCLHSYCEKCLQDMQKSNKQRTDNIRCPDCRQITPVGVCGAKANIFLARLVEDAAVSEIVTRSKSAAAEISCNVCKKREAACRCSECAVFLCVVCRAYHGQLPATSGHGVYTLEECRAGKAGGVTGRFDAPDCPDHTGERCRFYCLTCRKLICRDCTVLDRSSSEPHEYTSLAAAAPLERHAADALLSRLENKVPDLETSLHVLEEMGPALKKRSDMAKAKVQAVANKIRESLAEEEKRLLKEIRLESQKELKALKENQNEVSATLNNARSSLKSTRLFVQRSTDTELLWLHPTLVKHLEGLVLKDAPGEPLALSFTESDDDMSLGVLTKENITEAVKAAVEKTKGKEKPTSRRVTEKASTSRPKEPTVSSNKENPPPESEDCSDSEDGSNSEDSSDPEDGMMGSSSLSVSDKPSTLTKQPIPIGRDTPADRKELGRQPAGTSAPKMKPASEPARKPKDAAPPSDRILRSSSKANATQNQASSRPANRQQAGISVAPELGQLTEDAVDSPDCGQALHRDGINPSLMRVAGLAKKPSQMTQPEQIPTRLSQQERQNRMQAPTMYTSAPSNDFNYNPNFAAAAGLFASSVQHAKDEEPTHPDSDRAQEATVHGVQSHQDYPLITSPNIQRGDIQRVANKYDTDSDDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG92</accession>
    <name>A0A913ZG92_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050448.1">
        <property type="nucleotide sequence ID" value="XM_038194520.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050449.1">
        <property type="nucleotide sequence ID" value="XM_038194521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194520.1">
        <property type="protein sequence ID" value="XP_038050448.1"/>
        <property type="gene ID" value="LOC119723720"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194521.1">
        <property type="protein sequence ID" value="XP_038050449.1"/>
        <property type="gene ID" value="LOC119723720"/>
    </dbReference>
    <dbReference type="GeneID" id="119723720"/>
    <dbReference type="OMA" id="DCATSEI"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11828">
        <property type="entry name" value="SH3_ARHGEF9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="2205"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="2305"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="2520"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1463"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1652"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1855"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1938"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2093"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1497"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1552"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1652"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1670"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1681"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1746"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1769"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1781"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1868"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1946"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2121"/>
            <end position="2149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2711" mass="301006" checksum="9717D298A4994AA5" modified="2023-02-22" version="1">MASTRDRHANAVTNKEGSGMEGAGVPQRQGMATRIPAPKWKTTAKCSGTDLPTTKPTTGTHKTGIRPAQVRTNPRVTRQGVRSKADSESSNDSVRSPTVSRTEQDFEGSRTGLRENLSPLSPSTTLTRRGAFRYGRGVKPLEVLNLGSGATTLPRMRPKRGRDPRNLDIFTNPEVFDAPSNEDSGKSQATKKDKQTKGEQPNTSTRKTSQRPQSLGRVSGIRQMFQESAKITKPGVPKAAGPRISKGIKGGTGPEKGVDNKSESKSPEPLPVSNHSQLGAKTDKPRDQKQIKNTMSHSRTSPNKVNSDINPRPTRSVHSEQKTIEMSPKAPPRRQRTLPSSTNGLSSNRTPIPKTYKIPQETSNTVRSPGTPEPPPRHSKHVSAGSASPRAIPTNIPRPQSLKRRVSYQPGPTQATLSPRHSLPANTRTRLSNKSSLSFPQGTKSLSPIDAVKNHEERQRSHSASQIPLPISRRSSLPQYRQVKLRHKVPQSDRPSPIFRLSLDGADSGTEYSSSLTTTPSECSIDIDQSYEEGSPVCQTTPSRFYSISGLDMAKVQDDSSTENLQKMPFQDTETTPDDVSKEIKQTSNLPAESGECLLHARHREETLTHEATLTQEASPITDIVPKDKETNPAEFGFDGDGSTTPKNETSDTTTSERELLENEAPPSKTCKSDSLGNTKQTDQQNSTYPIERVDPSQSTDSSKCVEGDESVCHTTQSISDSERNLKTFLRTEETVRSVERTEICPRSKSDTEHPKAIGFAQSRMGREIALRVARGDLKASSVDGDGETLCEVASTGENLSEPHEVPSAESSVPTHNTKATVEGTTCISGDQESTVGPQNSRRRRKISSIESPHKALASTGDILRDAQSSDNPAIISGSMILEKMMDTEEAVPRPNHRKNSFHPYAKEKSEVEQRYLQSCSDPIKLLEFLMNVDDPPKVKGQRGERTEPVLVKRRAKSDVQSPSQRRGSTDNQEVSRWSMPSALEQWSQNFWAQLTSTGRSRQGSRTKELDVTGVSDGRVPVTPEMPSANSKTNLTPDKRDRIQGVESQTLLSSERKDSRETSHPNARRQWRKHRWSIPVETGSLPPSIGGTDPIKNVAEPSPESNKIAEPTLKRKSWWRWSFPVPRQKSSRSSLYVKNPNSETLKQDPVASQNSKETHQLPSSQGNKQLAKSAPSVPSRKSGKRAPSFSDIADTSTSSPSPVKIFVDSSYAEQNNGFCHPKPSRDAGLSSIVTDDQQLLNVSADQVPVSTETETASDDAAISSAVRGDQSSASSGPQFKKRLSWKRDKSLEMVCYLERRDSGELTGSEDECISDEEECNENESLSPLSPLEFIPEYQSKIDDAYDDYDDENQDANVPYVLTDHNEELSRASKTASVPTFSAWVLPSDELKSKLESVYAERQKSESDDAGGDVWKLDPNARNSFQSGSAGQEEDLGASPSIYHPESSMRDAVVMSMGIGKRLSLKQRLSIDQDSDLNENTETMGRQSRDSIKEVYSGSRSPTLSILANNNRPKLSRQRSGSGSDSVKDNRRKLDDVSHKSRLRIERDREIKSSVSPSSPAINETSQNTPPKSRKSGQSLTVPVETEINGEQDKEKDTDASVGESLQAFRRRKKSMAIALSEGLLDLQEEHAASLEKTSELQMVSHISQLNQELMQLTQHSPPGTPPIPNYHRRGSLKRSGSRSSLASLPGSATSPRSFPGIRLWKSIAQFQTTSDDPAIVADEPSSNVPSPEKDRSSTLPAPKKTSLKDDEDPKEKTVSPKLLLSRIKQWSKKKGQAKPKARPEIVKLDPKELPEDHGKTDREEKEDKEDDSSTPTKGSLEHLPDYVNIRNNSPKLPHKPLVAFRPVPMSRDTALRQTWHGMPSRKTNGNDDDRDEDRLGGSNFQRSNSLRHPIRQRKRGVSPMENAHLVAMHLSTETIPGSSVDSGIVKDRGTEETYLAGDSDTSSSNLCSPCSSLGGSNPPSRPLSSDIVDLQWEKGSVEGQAMANGGLTEERKLSAVTIGRRESGTGIAKSSRRPMVSRLSISLSSQPPNAASPDTPEAITSPKKVTFSLAEDITKKAVEEDLKRLPKPLHLPRRIKTDPGDTRTIACVVKEVEDEQRDASSQPRPPLRRRAQSELSSIHERSWDDDIKAQPPAVKEEADKSEKGTLARPKSIPDHMSLLEGEGAEMLPRKNSLADLIGSEVGEVLSTFGNQYNFEAYSPDTMPTFAEALWDHVTMDESELAFKAGDVIEVTDMRDKNWWWGCRDEVEGWVPAQFVRLRVSQGETVEECMERLREEREQSNKTLTAKKNRKVSLSFLSNEQVRAKVVEEIITTERDYVRHLHDVCEGYISQALDRPEMFSEEVVNTLFGNIEEIYSFQKGFLLQLEATIIQDRPQLTRIGGCFLEHKSGFETYSEYCNNYPNALRELKQLREKQKYGQFFEACRLLQNMIEINLEGFLLTPVQKICKYPLQLRELLKYTRPQHADYQELQEALEVMKDVALTINDRKRRIENIEKIAAWQKAIGDWEGEDLLEKSTQLIHSGEITMLAGKRWTSGRRAFLFDHQLVVCKKDWKGTLLYKKRIDLDVSEVADMPDGKDLQWSVTVKHAFKIHDTQLNKLHIFSCKGDSEKQEWLKMLAKERESVMKDREKGFSIPTAIREAAMKNVMGDQPSKPQDVAAVVTRKVSEMPYAYQHKILKAPNKKVPLSKGISSTDVFKKKGKGLFGIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGK0</accession>
    <name>A0A913ZGK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear receptor subfamily 2 group E member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050140.1">
        <property type="nucleotide sequence ID" value="XM_038194212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194212.1">
        <property type="protein sequence ID" value="XP_038050140.1"/>
        <property type="gene ID" value="LOC119723514"/>
    </dbReference>
    <dbReference type="GeneID" id="119723514"/>
    <dbReference type="OMA" id="QKCFAVN"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06957">
        <property type="entry name" value="NR_DBD_PNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="199"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="49889" checksum="D26901D9277F9DD7" modified="2023-02-22" version="1">MGRTLPNPVPCKVCGDKSYGKHYGVYCCDGCSCFFKRSIRRNMRYTCIGKGNCLVDKARRNWCPYCRLKKCFGVNMNKNAVQEERGPRKKKPQPKPDAAGSSGDLCCRGTGGGSHSRALAAHAAAAKSNHPKPSFRPFQPWTSKTPGWREHHAAVAAHAAQAAGGPGSAFRVVAVRSGLFPGGVPPHLSPTLPFDGAAERGMLVPTLPSQFAGLRMEDRAALLAKRLGDRPPFPWATRPSGAGPILAIPAAPSPCTASIEEIATHVLVHAVRTSRSVQPFQALDSWDQAAVLQECWNELFLLHAAYWPGLDFCALLSHSNLRSESAGAGSSSSSSDSSVTIRQRNEIIDDIQEITVRLRTLNLSSYEFASLEAIVLFKPDTTKTLREKSKVEFFRDQAQVVLAQYENVVHPESPARFGKLLLTMPSLKRVTGEDLEELFFRRTLGQVQIDKILDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGS0</accession>
    <name>A0A913ZGS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050987.1">
        <property type="nucleotide sequence ID" value="XM_038195059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050988.1">
        <property type="nucleotide sequence ID" value="XM_038195060.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195059.1">
        <property type="protein sequence ID" value="XP_038050987.1"/>
        <property type="gene ID" value="LOC119724138"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195060.1">
        <property type="protein sequence ID" value="XP_038050988.1"/>
        <property type="gene ID" value="LOC119724138"/>
    </dbReference>
    <dbReference type="GeneID" id="119724138"/>
    <dbReference type="CTD" id="9282"/>
    <dbReference type="OMA" id="KQPAYFI"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056877">
        <property type="entry name" value="Med14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055113">
        <property type="entry name" value="Med14_RM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055114">
        <property type="entry name" value="Med14_RM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055107">
        <property type="entry name" value="Med14_RM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056879">
        <property type="entry name" value="RM3_Med14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056878">
        <property type="entry name" value="RM5_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25069">
        <property type="entry name" value="Med14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22981">
        <property type="entry name" value="RM2_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25065">
        <property type="entry name" value="RM3_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25067">
        <property type="entry name" value="RM5_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22984">
        <property type="entry name" value="RM6_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22983">
        <property type="entry name" value="RM8_Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="12">
        <location>
            <begin position="34"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM2" evidence="13">
        <location>
            <begin position="301"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM3" evidence="16">
        <location>
            <begin position="381"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM5" evidence="17">
        <location>
            <begin position="667"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM6" evidence="15">
        <location>
            <begin position="789"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 RM8" evidence="14">
        <location>
            <begin position="1257"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 14 C-terminal" evidence="18">
        <location>
            <begin position="1346"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1489" mass="165136" checksum="0B70678AFC48167C" modified="2023-02-22" version="1">MAPILTPQAQAQAQMSLTPVLGQRAASPSGTNSISLGLLLEFLIQKTYHELMVLSELLPRKTDMERKIEIVKFARSTRQSFVRLLALVKWASSAAKVDKCAAISAFLDQQSLLFVDTADMLSHMARENLVHARLPNFSLPVAVDVLTTGQYRRMPTCIKEKIVPPDPISQSEKANVLQRLNQIIQHRLVTSKLPSQLADLSIVDGRVKFSVPQEFEATLTLMGDDPGIPWRLLNIEILVTDPDTGDGKALVHPMQINYIHQLLQSRLFGDENMLQDMYSCLHSFCQSLQLEVLHSQAQRLIRERWGEHVMIEKYMAGQCLTLAYWRSQTFNVDKPEEYSLSIGIDTNDTAKPLQINHNPPLSVEDANEVNRAIRCDRLSIERLLVETIIMRSKVKLQELQTILEKELTNTKTRIEGTPPLLCVPIVEPCSQSEYLTISVDMQTGAYQPYIAHADATLLEEMEHCLNCELIKLYQYITKLSYMLSMHHCKQSIQQLPCKCTDKLPLVAISAEHPLAKLSQNRLYVHLVKHKNYYVVVEFNSIKNQTNLQTSYYLFHTRQAAFFDQSAGEGVPAPSQSDWDSGEPFLAPLSLVPLDSKSCSHYPDTLEEAEESNRNKKRKLGTSLTSFKKQRLGTHCEYFQRELVHIIALCDRRIPFISLCEELMEQGIPFQGIQVEAEGIGMVVKLCSLPAIEGISEETNMSLANALLECSFRLQLRGNLLAWQVQLTFGNCPVRSTSPREQGSTRCLYLTYSSTSPVINHLLQDWKAIGMLYGPVQDLASVVNDPDLPLSAFVEVRSFTFQKLVLTYGRDKTSTVTIFWDSRESRFHLRLAVVGTACSSNSHLLVHHQLEHEFNTHCNLTRLMQNMCDSQQPLQAISKLPMAPALGGLSSHAQVPSHTFLVIPQSSIHIRVFFRKNFCLDILCKGKNTVTIRDGVYLPSKDSKGVEGLIPAWNLKAFLEMFVDESVTNMRRRSVNEDDNPPSPISMDTGDSFLMTQHHSVPSPMARLGGATSSGFVHPMTPPTAISTSNPATPASPHTSMLSQQYSMSPGASGYPLASPPSIPSNIVPSPSSTMLNTASPALAVGSPSNVHHHVPSPGSFVPTPSPNIQMHSPAPGPFISPQSLSENANSPYPSMGLAMPSPGQRNWPASPSVPGPSPINRYGVAHSPGMAASHSPGSSGLGQTTGSAPTQAPMPMRPARHLPSRSPVASIPTALSCEAITKLFTPAPTPGVPGGPSASLCCPMERFLGSIYCKRYLHRVLQIVDGIQEVPSNEPGTLHFRAESLQYWVSLNPSTMQTLHLVVKPNQDMTDRWNLDEIQVFERYFESKVVCPPYKLHAILAFLRALSAPTRILKDLVQLMRLELLPDRTLKWTIQWCLTVPPPDVFGFAAPGTAALAIKSKMLFFIQLTRIGINPPVGQDLQSIVIPIVHDMQANTTSYIDRAKPPNVPASIATVRNMLERSNSLYQNKVECTIFPVVRDLMANLVIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHH8</accession>
    <name>A0A913ZHH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050516.1">
        <property type="nucleotide sequence ID" value="XM_038194588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194588.1">
        <property type="protein sequence ID" value="XP_038050516.1"/>
        <property type="gene ID" value="LOC119723746"/>
    </dbReference>
    <dbReference type="GeneID" id="119723746"/>
    <dbReference type="OMA" id="RHETIHN"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000247">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="414" mass="46113" checksum="6D86A061AD4019F5" modified="2023-02-22" version="1">MEKKEGSSLEVVSVDNVPLGGADDKASSSKCDEIRELRHPTSGKQLFACNVCNKVFFSQCSVRSHLELHRGDRSFVCGICNKVLLSQNELVRHRQSHTFARPHHCTDCGKTFADKSNLVRHQLVHKGEKRFVCAICGKAFLRRSNLTVHHFTHTTEKPYTCQICGDGFTNKRYLLSHQQAHNEESSFICSVCRSDFTSRESLAKHQLTCRSSERANDEYTCDICGKVFSEESSLSNHKKTHTEYVEGKTVAVAQGTHSPPAPKQLELGDQAKTEYDSNISAKPLPDNATLQGPQLTHSTPGSHAIICQICGEPFDTTADLKRHETIHNNKDQLFVCGVCGKGFTKLHCLRTHQRIHQKETGHKCNDCGKVFAQKRILLSHQRGHCSQASYISSQTFSSPNDLEAHTLGASQNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIB8</accession>
    <name>A0A913ZIB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ECT2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050801.1">
        <property type="nucleotide sequence ID" value="XM_038194873.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194873.1">
        <property type="protein sequence ID" value="XP_038050801.1"/>
        <property type="gene ID" value="LOC119723952"/>
    </dbReference>
    <dbReference type="GeneID" id="119723952"/>
    <dbReference type="CTD" id="1894"/>
    <dbReference type="OMA" id="PIYDVHK"/>
    <dbReference type="OrthoDB" id="9997817at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17733">
        <property type="entry name" value="BRCT_Ect2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17732">
        <property type="entry name" value="BRCT_Ect2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01229">
        <property type="entry name" value="PH_Ect2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049396">
        <property type="entry name" value="ECT2_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21243">
        <property type="entry name" value="ECT2_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="410"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="100096" checksum="97C6553975B5A8C1" modified="2023-02-22" version="1">MAATCASELNMLNDVTVSSSVSMSVTTIQDQDADCEHRICLVGEETANNQQLLQDLQTLGLPVTTSETGMENVIEPAGVETLFVLTEFEGEGFENLRRNGCRVLGAPVIYKCAAEKQPLPLTSRPLYCCHMSQLVICFXGFVEKEELKRLAELVHHMGGSVRRDFSAKVTHLVANGTTGNKYRVAVSLGTPIMTKEWINMAWQHRHDTQISATTEAMLQYKMAPFFKCVLAFVGFSAEEQKHMEEVTLTQGGTYAEVRDSTCTHLVIEDNATTEMPTTDVKRVKQEWFWASVQMDACADESLYSYHKTVSSDEVLNTPGNTPVVRTSRKRRRLKDSLAALSQENDDLASPRLPKRRSSTLPDPGTVLSMSASSLLDATPDESLAGNDRCTPMQVDDTPVSRNSQAQPISKRHLTAMELLQTETNYVGILHTIITVFKEPLETEQTGGPILDQEEIKTIFSKIPEIHEVHQRLQEDLERLLDDYSEDKSIAQIIIKHSADMIKAYPAFVNFFELSKQTVLDCDKQKPRFHAFLKICQSKPECGRQTLTELLIRPVQRLPSMILLLSDLQKRTPEGHIERDHLAQAVDSLRKVTEHINEDKRKTEGHTQMFEVMNDIEDVPPHLLSAHRSFVMRADMTEIGDKENGKGENFSEKGGSISMFLFSDTLEICKRRGKPGASFKSPHSSKAPQKFYKHIELVPLSHIRRILDVQETEECKNTFGILCKPPMDTTDRLDRLYLFTLVREEPQKEDWLKTMCKHMADVTCKTDADNFLTKITPEELEITKSDFDKGKLTKAMRKARRATRKVGRTFSFNKTPRRTLQRAASTATLNMSPMVMSVDQAHPAEHMDLTGARLASTSSLNAKVTSPLATLPPCTPSKLKSVTYGPSSANWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK18</accession>
    <name>A0A913ZK18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052162.1">
        <property type="nucleotide sequence ID" value="XM_038196234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196234.1">
        <property type="protein sequence ID" value="XP_038052162.1"/>
        <property type="gene ID" value="LOC119724916"/>
    </dbReference>
    <dbReference type="GeneID" id="119724916"/>
    <dbReference type="OMA" id="CAVFFYF"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005449">
        <property type="entry name" value="Translocation_assoc_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="119"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="44680" checksum="F868843900858A77" modified="2023-02-22" version="1">MAIRRRGGSTKNPPILSHEFVIQNHADIVSCAAMLILLGLMFQITSPFSSTFVAMQYNVTVNNTEDPEAEPTTLYHHGLLDSCSVFFYFLICVVIHAVIQEYILDKLNRKLHLSKVKHSKFNESGQLLTFYLMSVIWGIQVMIKEGLTENISHLWDGYPYLLKTFRFKFYFIVQIAYWLHIYPELYFQKVKKEEVSARIRYASFYLAFILGAYILNLGHLALVCLVIHYVAELTFHAARLLYFGEKAEVSGPLFSLWFALFLIARLSVVTLTVLVVWFGLGKLETTGLDIKGGNFNTPLIRVSIVAGVSLFQALLLWNFLTFQLRRRRENQLAAAPRKKTPMGKSKDKKAKKEEVNKKLKAESVEDEGFGDMAVVAPAENGGMRTRSKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK31</accession>
    <name>A0A913ZK31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051440.1">
        <property type="nucleotide sequence ID" value="XM_038195512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195512.1">
        <property type="protein sequence ID" value="XP_038051440.1"/>
        <property type="gene ID" value="LOC119724446"/>
    </dbReference>
    <dbReference type="GeneID" id="119724446"/>
    <dbReference type="OrthoDB" id="10604265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="892" mass="100339" checksum="225FF04B761A052B" modified="2023-02-22" version="1">MPYVGIFTEPSAVGTMFLKIHFRFLIVFFLSVRSSDEKPSQRTVFTMVSRDNDTFEIVIQQHECPENYFLHKLAPGEFYLPNGRDITEETAELCLRCTRCDDGVEVKRKCSQYHDIICSRNCQQPGYRFDEGTQSCQHEKVLDEGYNHEELRQWLAEQDAKEARTRASDLVSEVGSTQRPGFTRTSRTSASGKVLSTRATEESVRPDMLMPVKASLYEKDDSEDQNTGTISWMSSEKKPSGETREVFPVEANLDDGWGYQDLLLIASGTLFVIVAMTYVYVAIQRFRPQWFRRRDWMRAPSIPVIRAEAGIPRVRASAPPTSTVVRILSPNKPSSVQTVKYHPIANDPFANTCRVCSVRSTGDEESDEWMSVVDSDGDILDYDSEMGSSGDDLEVELGQHGGKGGAEIGGGASDGNEGGYLVEVSVHSPAQHEVCIDVHDSDDVILCDVTASEGQAVKAGIHAIDEEQDGGDDENFGEAETECIRKVARSNDLWLARVRKKFVLQVINEHDETDSDKNDSGYQNLLFEDLAGVEDGGMITSHIHDFSVVDESVLGGCGDEDVSDNKKALDETGEDDSETTQAAAGKTGSTEEAVEFNSERERIETDDDEENTNEQERIDTSEEEITDKREMPVIDTVNEQIPTGEIIDIADKQITIGDELIAEQEEIIDTKDVLIQVRNESVEDVEEQHLELKNGRGEREKLVTHIDRVRLISKIDVFVFELLSHLTDFTVFRFSNLRTCHQNTMDGSPRDELCGSTDLSETNLMNTVVFVVVSSRPHWIRIENADKSVKPAILETESATRNNIDRPDKVVATFRFFSWVGDCVTFVQNLPSPVKARLREIFQRGQTEMRNFGQVLEQLARFCRSNTLEEKTNITKYEPRQRKKPKLDSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKR3</accession>
    <name>A0A913ZKR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051636.1">
        <property type="nucleotide sequence ID" value="XM_038195708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195708.1">
        <property type="protein sequence ID" value="XP_038051636.1"/>
        <property type="gene ID" value="LOC119724596"/>
    </dbReference>
    <dbReference type="GeneID" id="119724596"/>
    <dbReference type="OrthoDB" id="5967898at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="41450" checksum="5EA1418644E31AA6" modified="2023-02-22" version="1">MALDNCTALYFRDDHRTDSYMVYLPIDRTMTYYVIPVICVFGILCNAAFIIVVHRVPFMRTPTSCYLVQLAVADILYLMSSSSARIVLYSMTPFRYDIFPLGFVTGCILRPAFSYISYFASLFFITSVTFDRYIAICRPLQARLRTSTKRSRLSVAFWVLAVVAAACLLPAFYTVLPVVIPCKNYPREIMVCQSDFFPEWVSYVRNALRTLPFFVSLVVNAVMYASIVRAMQQRSKLQDTLVTSSQRNAIDRMVLTTGGLFFLLLSPLESYYLVETITETIGIHLLTFEQKLTILWVFKTLIYTNVAINPIVYNITNWRYRIAFKKVFCCQKDRRKIGSNNIFTVELALQNGSSVTPSTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPT2</accession>
    <name>A0A913ZPT2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053727.1">
        <property type="nucleotide sequence ID" value="XM_038197799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197799.1">
        <property type="protein sequence ID" value="XP_038053727.1"/>
        <property type="gene ID" value="LOC119726197"/>
    </dbReference>
    <dbReference type="GeneID" id="119726197"/>
    <dbReference type="OMA" id="LARCKHN"/>
    <dbReference type="OrthoDB" id="10554731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037410945" evidence="2">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="125" mass="14231" checksum="B5B110BDD0BBC4FC" modified="2023-02-22" version="1">MTAMARLLLVACLIIGLTLSVQAGCPPGMSLARCKHNSGTFKKGLIQELLERKNLKFDELDDKTLQRALDLLLEDEKKDFGGQQDFTLEEEERGPPRRELEGEDAERARSDEHLRQLLLKVLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR09</accession>
    <name>A0A913ZR09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053526.1">
        <property type="nucleotide sequence ID" value="XM_038197598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197598.1">
        <property type="protein sequence ID" value="XP_038053526.1"/>
        <property type="gene ID" value="LOC119725972"/>
    </dbReference>
    <dbReference type="GeneID" id="119725972"/>
    <dbReference type="OMA" id="DSLMEYH"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="359" mass="40311" checksum="5E774E2771B1DAC9" modified="2023-02-22" version="1">METDLGGWLVIQRRQDGSVDFYRGWADYRVGFGDLAGEVWLGNDNLRTLSNSSGSWDLRIDLEDWDGNTTWAEYGYFRLISGQDYRLSFDSYNANSTARDSLANHNHKPFSTKDKDNDSGNKTQRMIKELVDYGSVYFDGHGGTPEVSVAAYSDCQSLLKAGYSVSGIYTIFPAGFADGLRVYCNMETDGGGWLVIQRRQDGSVDFYRGWADYRVGFGDLAGEFWLGNDNLRTLSNSTGSWDLRIDLEDWDGNTAWAEYGDFRILGDDYSLSFDSYNADSTAGDSLTFHSHWPFSTRDNDNDLVSIINCAEDVHGAWWYVACSQSNLNALCFGQLRETNTLPKPYFTWPHVPSGSTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR44</accession>
    <name>A0A913ZR44_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053615.1">
        <property type="nucleotide sequence ID" value="XM_038197687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197687.1">
        <property type="protein sequence ID" value="XP_038053615.1"/>
        <property type="gene ID" value="LOC119726070"/>
    </dbReference>
    <dbReference type="GeneID" id="119726070"/>
    <dbReference type="OMA" id="KTPEMNE"/>
    <dbReference type="OrthoDB" id="6083617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF44">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="131" mass="14104" checksum="50FA74DAF223D587" modified="2023-02-22" version="1">MAYYPPTQPQPAQGYAPPQYNASPPSVTAVQAVPPQPQTIISTSHVMPQDYFGLALFVTLCCCLPLGIVGLIRSNDVRNRFLAGDIAGAEQASREAKIYSYVGLRIGIILIVSTVVTVIMNLGTVNRNIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRV6</accession>
    <name>A0A913ZRV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WASH complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054134.1">
        <property type="nucleotide sequence ID" value="XM_038198206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198206.1">
        <property type="protein sequence ID" value="XP_038054134.1"/>
        <property type="gene ID" value="LOC119726495"/>
    </dbReference>
    <dbReference type="GeneID" id="119726495"/>
    <dbReference type="OMA" id="RCNIFIQ"/>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="511"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="4">
        <location>
            <begin position="873"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="126539" checksum="B04FC695B74F501A" modified="2023-02-22" version="1">MTVFASLCCEMNTLKHEAEMKFYPGVMFYGEGEPETGLEEGEAQVQMGRMMPFMQETSCFINRCYEVIKTTIHQLASLYNNSKTAPKIIDVTHVHLQTVYEHLGDMLRVLITLDEIVANQSTLKDHWTLYKRMLKSVHHNPTRFGVEESKLRPFEKLLMGLQGQLLDGMIFQNCVEQGFDNNSVLVSKNSFFAEEFAFNIRNMFTQVDPKIGEINEINQRLQYVGICGLYVLHFQIFRVIDKKMFKSLWDVYRRVPAITLTANIVWSANQFLLKSLSPHIARLLDKKSQQSVVQSTQGYLQQKSQSLVREVQVYYMQVCSWMIKMESSLTAASTVMEDLTHKCNLFIHGLLFAYNISNLVRTVMNLHAHMNKPMTKTAVLALCRLIEMLKSIEHTFHRRTMLVAESITHIIQYLQFSALALVNGAKKRIISDKKYSEKRLDALSALVLVENALSGTATKERRLIANLALHVGTQMKAFKEDELASYRTTMNKLFLISDLREKLREACDCSFLYWHRVVFPLYLADRFENAVDAHRLHYMFGALADCVPPIIQSKHLESPQLLLDSFDKEINTQFREHLLDPLCRSVETDLRLSIHNHLQLDSRNPFRVPLQDMSHFIKMRPIRFFNNFLDIKAAVTHYLDKTFYNLTTVALHDWKTYAEMRNLASQKYGLTMTEAHLPTQTLEQGLDVLEIMRNIHIFVSKYLYNVNNQIFVERSSNNKHLNTINIRHVSNSIRTHGTGIMNTTVNFTYQFLRKKFFIFSQFMYDEHIKSRLLKDLRYFKENKVEIHQMYPFERADKFNKGIRKLGLTPDGDSYLDQFRNLICQIGNAMGYIRMVRSGGLRCCSNAIRFVPDLDDIVQFEELVSEENLSEEAKTAAKNLDSVIGNLTKNFAEGTEYFKMLVDVFAPEFRSSKNMHLRHFFMILPPLSLNFVEHSINCKDKLSKKNKIGAAFTDDGFAMGVAYILKLLDQYNEFDSLHWFHSVSFKYKKEKETVKKQQANDEKLQQTVSLTIKRLDTYQREFDLLYYSLSSARIFFRADKTAAEEQEETKEKEKEEAAAEEDSESQQGALPEAPNNQAAIQAPPQATLPAIMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS02</accession>
    <name>A0A913ZS02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054547.1">
        <property type="nucleotide sequence ID" value="XM_038198619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054548.1">
        <property type="nucleotide sequence ID" value="XM_038198620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198619.1">
        <property type="protein sequence ID" value="XP_038054547.1"/>
        <property type="gene ID" value="LOC119726775"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198620.1">
        <property type="protein sequence ID" value="XP_038054548.1"/>
        <property type="gene ID" value="LOC119726775"/>
    </dbReference>
    <dbReference type="GeneID" id="119726775"/>
    <dbReference type="OMA" id="EEILEMX"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="829"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="172"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="344"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="860"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1010" mass="115427" checksum="D42231CCA052788C" modified="2023-02-22" version="1">MYSPRQSPLPLDHSGTGAAAERDGSSSRSSSASGSAASGTRSPSRSARLRSSRPDVSTSLPMETIQSLNAAYNAGPIYMGDGVGSPVQSRASPVSSGASGKSNSLSPRNSPTPSHDSRSSSLGSSQGLHGSPLTGSDGAEPHPSDQLAMNNSNSHSNSHHPEDMRPPQDSIMLDVHTQLREYQLENASLKQELEAKEAKLASSMNSIKTFWSPELKKERALRKEESMRMQVLREQCRTSLEENQNYCQDLKQFQEELQQQREFNAQLQASLSTHAVSGAHPHHEVDALRSDRDRLSKEVFLLRKTLEEMEIRIETQKQTLSARDESVKKLLEMLQSKGLPTKHLEVEREEADRLRSKVVEAESRILQLETMLDQRDRERSRMADEDKIATLESRVREYEHELRRVRSLGSLSPEEREDRQREINDYKSHSKILKSQVDQFKLELNKKSSEVQALQTKIETLTHQHQDYQAHVSLLKESLAAKEQHSSILQADVEALRTRLDEKEMTLVRKEQLLSTLSTDKTKRYSEVNELKEMLDIKERKIGVLQRKLSDLTNAMDIKERKQYILQIKIDNLQEQLHDKEEQCNQLRAKLSSVQADQTSSDSAMSSLEDALMDKDKALDRVKEQRDRNIKEHEEELQNQQKQLKEVKTRLENLQKELSEKEASLMDLKEHASTLASSGLKKDSKITTLELAVAQKTEETARLEADLKKKARKIYMLREDRDEEEKRSAKALEEAIARHKDEVAKTQNEVDRLLEIMKEMEGEKNDKDKRVTELEIIIRKHCPSQLKDATKRLTGVKRDQQLQKRKNAQLLEEARKREGELSTDTHQLQTFVRQRDDRIEELEEALKESVSITADREMILAQQTQTISNLQRQIDNLKRELEQVKKQLSTASNKLSTTTTVLREKEAKLSALQNERRKTLEEAMEMKQEAITAAIGEKDAHIALLELNRKNPKACDELKGLKKEKDALVQLLKDETQRRIKFIHNDMERPTALEQSPVTPEQDEEDGIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZST2</accession>
    <name>A0A913ZST2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054682.1">
        <property type="nucleotide sequence ID" value="XM_038198754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZST2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198754.1">
        <property type="protein sequence ID" value="XP_038054682.1"/>
        <property type="gene ID" value="LOC119726903"/>
    </dbReference>
    <dbReference type="GeneID" id="119726903"/>
    <dbReference type="OMA" id="METRCSE"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="415" mass="47496" checksum="9A79C59EE1EF1B93" modified="2023-02-22" version="1">MASNVTVQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLHELRQSQDPSGTKLTCPLCRHETMLKGSGVADLPNNCAFSALVEEVTMQEKLLEGQGSEIKCQNCKEENQAISRCMDCDHFLCQECQKAHERMTVINSHKIYTLAQLRSGEIVYKSKLREEIPKCGKHPDQNLNVYCNTCEQVICLMCTVLDHEKPKHSCIGLPEAFEKCKKKVEELIAKIGKSKTELNSTIEKTCISRKKLDIMFANTKKKISEKADQEVAKIRQEEQKLLKETARIYKERVVTFEAAQANNSKEVTQTEHKLEEVIQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDKLSFMDYEDDERSLGRLILEEEPQAAAKQSPRPLTRHLTSNKRKPLDARADIVWLLRAQSSSRCNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSZ8</accession>
    <name>A0A913ZSZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054878.1">
        <property type="nucleotide sequence ID" value="XM_038198950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198950.1">
        <property type="protein sequence ID" value="XP_038054878.1"/>
        <property type="gene ID" value="LOC119727079"/>
    </dbReference>
    <dbReference type="GeneID" id="119727079"/>
    <dbReference type="OMA" id="CYYFITI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000014">
        <property type="entry name" value="Cytosolic non-specific dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="478" mass="53545" checksum="FF8EB68E9FA16BF6" modified="2023-02-22" version="1">MAGEFLPKLFSFIDENQDEYVKRLADAVAIQSVSAWPEKRSEVKRMLEVVAQDLRKPEVGATIELADIGMQELEDGTRIPLPPILLGHLGDDPKKKTVCIYGHLDVQPAKKEDGWSTDPFVLTEVDGKLYGRGSTDDKGPVLSWLNVIEAYCALKQDIPINIKFCFEGMEESGSEGLEELIVARKDTFFKDVDYVCISDNYWLGKNKPCITYGLRGLCYFFVDVECSKKDLHSGVYGGSVHEAMTDLIALLDSLVDVTGHIKVPGVYDKVAELTEEEASLYGPIDFDMEEYRQEIGTERLLHDTKEKILQHRWRYSSLSIHGIQGAFDGPGSKTVIPRKVTGKFSIRLVPNQSLEDITQLVVKYLTDIHKARGSPNKINISVHFRAKSWLSEFDHPHYIAGRKAVKTVFGTEPDMTRDGCSIPVCLAFQNVANQNVMLLPLGACDDSAHSQNEKFNRSNYINGVKLLGAYFEEVAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTI6</accession>
    <name>A0A913ZTI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054508.1">
        <property type="nucleotide sequence ID" value="XM_038198580.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054509.1">
        <property type="nucleotide sequence ID" value="XM_038198581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054510.1">
        <property type="nucleotide sequence ID" value="XM_038198582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198580.1">
        <property type="protein sequence ID" value="XP_038054508.1"/>
        <property type="gene ID" value="LOC119726748"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198581.1">
        <property type="protein sequence ID" value="XP_038054509.1"/>
        <property type="gene ID" value="LOC119726748"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198582.1">
        <property type="protein sequence ID" value="XP_038054510.1"/>
        <property type="gene ID" value="LOC119726748"/>
    </dbReference>
    <dbReference type="GeneID" id="119726748"/>
    <dbReference type="OMA" id="HTDKSTM"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053173">
        <property type="entry name" value="SAM-binding_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048711">
        <property type="entry name" value="WHD_Rv2258c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128:SF1">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RV2258C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21320">
        <property type="entry name" value="WHD_Rv2258c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="407"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58247" checksum="471FE94778B6271A" modified="2023-02-22" version="1">MSDQCDETLHETAAGDFQAHIGAIVSGGLTCLSIGLGVETGLFDVLFSLGQPKTCQEIAEAGKYKERYVKAWLDEMAAAQIVSFDASAGTYWIPEDHWPALKKGDKFSKAVLSTLSIPMLSEAFCSVKECFKLGGPAGVPPEQYSHFDRYLSDKNSVWFNHYMLQSFMPSIPGLVHKLEEGICVLDVACGAGEATIAMAKQFSKSQFYAFDICESAVRTAQAKVRTERLTNAHMVCQDASCLPSDWSGKFQYIISRSGIHDLPFPRAGLAELHRVLSDDGVASILEPECHSSLAANLDVAWAGKLYAFSLMNCLPVSLSCEGSEGLGAAWGREAATAMLQECGFRIVSVSDVLGDITMHFYCQKKEAKLVLFEASSDSSDPSEDAGPTKAEAFASVIADKGGGGLPSLALAVGRDVGLLDVMIARGQPMSCQEIAEAGKFKERYVREWLGAMVTSRIVCMDTSHELYWIPKHHVPSLQRSGVGSDPCSIPALSESFYRLVQCFKLDGPQGVSLDKHSQLSKYTCNDHSIWSVFQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUL2</accession>
    <name>A0A913ZUL2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054940.1">
        <property type="nucleotide sequence ID" value="XM_038199012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUL2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199012.1">
        <property type="protein sequence ID" value="XP_038054940.1"/>
        <property type="gene ID" value="LOC119727148"/>
    </dbReference>
    <dbReference type="GeneID" id="119727148"/>
    <dbReference type="OMA" id="LEVQIDW"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="266" mass="28754" checksum="5A90BFDE17D2FA1D" modified="2023-02-22" version="1">MLGLCGLAALVVRGAAYTINDMWDRDFDKAVERTHTRPIASGAISRSQALVFLGGQLSLALGILLNLNPYSITLGCLAVVPMVLYPLAKRFSNWPQIFLGVTTNFSALIGYSAVHGSCDWSIVLPLYVSCIAWTVIYDTIYGHQDKKDDMALGLGSTSILMGDNTKYWLTGFGAAMVSGLMVVGAMAEQTVAYYLTVALTAAHISNQVWTVDIHIPLDCWTKFRSNNRLGAIIFAGIIAGTLAKVSTKDSDSSTKLDKEEEQATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWT3</accession>
    <name>A0A913ZWT3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056108.1">
        <property type="nucleotide sequence ID" value="XM_038200180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWT3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200180.1">
        <property type="protein sequence ID" value="XP_038056108.1"/>
        <property type="gene ID" value="LOC119728108"/>
    </dbReference>
    <dbReference type="GeneID" id="119728108"/>
    <dbReference type="OMA" id="SETAYEC"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="691" mass="75758" checksum="87EC83370A14290A" modified="2023-02-22" version="1">MARFSQKNASFLIENIVEYVFFLWSRLITPCTMESIRHVCIACVLSLVLVHVAFSADKILYSCTFEDLSTCSLGVDPARVTWMIGDHMTDPGGQGPPADHTWGTEEGNYVYTKSEDKVKGTSLEPKLTSANFELSTGEGVLSFYFFLWGSSGNALKVHADCSDSDDMSLIGEFNLSTGSMDTWARAEALISCNGSFKIIFQAIHNANGSFIAVDDIALSSTDRDAVVSVKTPAPKTEPEKDVKEPDVTSDLPQVPMSTMPTGGVHNRPHETITLSIILFLLALLFMIISVIVHCCIWRKRKKCSVKMRNQMSVHNSGYNCPIHTNQPPGVIISMEDFKTPTGGQSDQNAEKASMRSSESGIVANGGGILARLVAPYQRVRSKTVPNKRSFEHYESIEIESDGDEDADKEKRVLSETGDKRKKGFLGKARHFTRSNSLPTSPGNDFYESIDHGPRKQGPLAYQVTDLLPGASSTSTLVGDTQDNRSDCSIPSIHSNHLKPPMLYDNLERRSPLLIHPSRHSPSSGNYTPPSHLNLNLSGSQCNLESLYNTVSTSQCDIASLSSYETPTSHVDSPSSINPHLNPFFQSVQPGDTYDSLNRRRRTNPSPVIADGAPSTPTPPSPTSSVPSSYQTPKPKTDNLPPEYQTLDPDAISDASFERSASESSETAYECPQTKKIQHVKSESSHDYEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXK9</accession>
    <name>A0A913ZXK9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056040.1">
        <property type="nucleotide sequence ID" value="XM_038200112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200112.1">
        <property type="protein sequence ID" value="XP_038056040.1"/>
        <property type="gene ID" value="LOC119728032"/>
    </dbReference>
    <dbReference type="GeneID" id="119728032"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="376"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="71378" checksum="74A6A59FF78DDECB" modified="2023-02-22" version="1">MAEAAAKTVWKISQGHLECPICCCLFKDPKMLDCLHSFCLKCLEEMMSKQKTETEKITCPVCRRETQVPDGGLQSLASSFFLSSLVDEVKQQEAVLGEASAPTTICDCGEGKEATWRCLDCSDNLCQECRKAHGRVKSTRDHQIISLGDWQESKMPPAEHSKPITRMCTIHTDHPLCFFCDTCNTLICSMCAALDHRSAEHNFLKIDDLIRSFRSEVENILQKFEKSRQHFKSTEKSIEHARKRLQKKLAQARSDIDAKAEAEITKIRNKAKLLTDKVDEIGQERDSEYEKALMNNREQMERADQTIAAVNDLMRQADDFELLELKLKVMHNLEFQKELKCEPANHGPSFIGVRCQDIVSDADLGEVCVSEKWQLKEEFGKEGTGDEEFYFARGVACFRNGDILVTDITMKRISLFSSTGRYKASVAKGDVRHQLEGPYGIAVTNDDLLFVTDKKKVKVFDTELQFVREFTPSVDDADGLSESNLTAVAVDSQRVAVADWGRKVISVHNLDGSLISSISNNMLDYDLAISNFGCLVFTNFEGQSLLCVNFEGKEMFNVKTLVNGKAAKASGVLCDDDETIYAVVHSGNRGGSAVQRYDSNGAFVATVAQGLYNPLGMAFTPTGDVVVTEIHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYT2</accession>
    <name>A0A913ZYT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRAS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056475.1">
        <property type="nucleotide sequence ID" value="XM_038200547.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200547.1">
        <property type="protein sequence ID" value="XP_038056475.1"/>
        <property type="gene ID" value="LOC119728344"/>
    </dbReference>
    <dbReference type="GeneID" id="119728344"/>
    <dbReference type="OMA" id="TINIDRM"/>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF11">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037597914" description="C-type lectin domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="2538"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="265"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="384"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="492"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="611"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="747"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="861"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="8">
        <location>
            <begin position="1451"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="2419"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1837"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2276"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1932"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1973"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1987"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2010"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2098"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2111"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2142"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2191"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2283"/>
            <end position="2296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2538" mass="280988" checksum="148D71CC6AEEA843" modified="2023-02-22" version="1">MAAFPRTVLPTLLIILHLTAAVIGQLVLVNRPLEVAIGRTALLDESVLAFQAPGEGEQCKVEVAVDEPFYQRVGRLDPQVFDCEFFPGTIGYIHSGSPLLDQDIIKLRAYMLTDTDTVIETFYITVNVTQAPYRVVQPMMNIAVDEFNGISDPIDMRILDFDFDRSPEASCFVRVNTVTSGLPRYGHLIRGVGDETQDVRALYENCDDFLYLNLRYQHVLPPSPNMDYIPLSIEVDDPQKHDQPFTERLYLPVDIVPAFENQHPVEAFLAQYILDVDQFILTTITTDVMSGSDDETRSGDLIFYVSKPPGPGEGSIVHLDDQSRPIESFRQADLSRLNIAYKAPDRSYPTVRLIEIEFVVYDEYFAKSDPVTLTVAVQPTQTNAPRVSVNRGLTLLEGQSRPIRPQNLEIVDNDNLDRVRIKVVSGPRHGRVLLNNRPMIMFTPRDIAAGSVVYRHDDSDTLKDSVELRITDMSQTVHTSFPINILPNDDSAPTLIRNIQIEVNEGQTVRVTRFALLASDKDSNDDYIVYRITTPPQAGEILKKYSADSFGYPVTDFTQRDLFRGMIYYHHLGQEQFMDSFDIILLDNSIPPNVSPTQVVLVSISPVHDLPPEVFPGATLSITVKETEIAFITREHLRYTDTESDDGDLRYTITTPPYVISTHSLTDAGRIFSTTGVVMPMKDPTIPAVRTFQQRDIDHHTIAYMPPFKEIGPDPREIRFLFSVSDLHGNVVLGQTFDVTVLPVNNRAPVIFTNNLMVAEGGILGILPTHFMITDMDTSVNDLVITLTSLPEYGVIVVGNVNLTVGGTFTVGDLSAGRVRYIHGGSEVPSDEFSVAVSDGVHSVSRKVLVSVSPVNDQLPEILPGLITRLTIAEGGEIPITSEVLAATDVDTNDMLLHFIVVQHPKRGVVLRNGIIVNRFTQQDVRQGSISYVHMGGETGKVPVQDSISFVVSDKSIPSSPNLPVHDIQITITPVDNQAPGIVFGNPYFVNEGGKAPLTLDVLSAIDRDSDLDQLTFHIVGQPQWGLVENILPSPGYEKSNAGKPIVFFRYQDIVNGNINYVQFNHSGIEPMADSFILYVSDGEHLSPNVSFTVNIIPVNDEVPVLTVQNFTVYENSFFKLSTDYIMASDLDIPMEMLMFSVIKSPRYGSLVDWALPAESRLPIFDFNLNQLLNTLRLTYVHDGSESSSDDFAIRVTDGKHTVQKSIFVTIIQVNDEPPEIIKNAGITLDIQESRIISPVVLLTTDGDTTADQLYYSILTLPRRGVLQRKLPDNTWMDIALLNSNFTQEELDLNLIRYLHTSDLGSKGLDRFRFDVTDGVHSTGKQSFRIDITNTKREPLQLINSGVEVLEGEFVIIPPECLTAFDNSNNPAEISFTINNPPTEGQLEDISRPGIPISAFSQISIIGQRVIYVHKRTDRIRNDNFMFSVTNGYQTRNDTFHIVVIPVDNALPSLIINEPLEVPEGGSLIIPPSNLEAIDQDTPPHIVTFIITHPLQFGRLLLAGIPVTDRFSQYDLNNYDLSYQHFSHLGQTDTDSFYFVVTDNTNQGFLIKDSVATQPVKFTINIDRMDSEPPRLITNEIPIKMESRNGRYAFILSRLTLYAEDQCAADGITYMIIQEPQHGYLENLVTRRRVQGQFTQQEVNDRSIMYIMNENIHVNNDSFMFSIYDCNGNALMGQRFDFRWPHIQFTRGDYMVCEAVGTLQINIMRAGYHSLSSFVDIEVSDLTAVAGQDYAPPRARQLQFDPGVNMATWDVDIIADELEENRERFRLTLTSPVNAVLGEHDKLTVIIKDSKDGACKGENHGVTITDTLPSCCPSQGSVPPEGLPSCCPDPGQGISYPGPLIPQQNPGIPVEDPFSHQPKPGDTGLPPEYPFVPGSHPSPEGYLPYGGEFVPDQGFVYPGEDPGFVPNPEVECCPPDPVPGQGQTGHIYPQQPDPGYGPYQPQQPGVSFDPHRPLVYPDDPGAYPRDSEVYSQNAGAHQTNPDVYPQNPQVYPQNPGGYPQDPSLYPQDSGSEAQYPDANTQQGQWNPGYPNSGGQHQTGGGDVPPRTYPDGSLPPQPDAQGQPVWPYYFTRDGQPYYPDQGGDPASATNSQGSRYQGPGRPYQQGQDAFSSDSSGGTYHQGGSNPQYPAQTGAVPQYPSGQGWNPQDPSAGTGHQPRPGDPYYPGTPAQYPYHQQPAESNPYLPGSHASSQGPDHQFPPSEQNFQSAGRAPVYAGEDPNPNPVGSRPQIPGRASNGQSIHSRPGSKVQGQPVGIWTNGSTTIWTLHGIASSPTVVRGHSSSSSSSSSSSSSSHKPQPFPAVVQGRPSTASVQESGVDPDGEPVPISEPEPIGEDVPEQPPGQAEVGPDEALPADQSLQLPPGCTTTSKDDFLIEESTGSMYKCNGNRWVRVEWSHIQADDATNQDLGCGDGWHEFDGMCYLLATDPETWDEAQRICRESYQGNLVTVSTNEIYNWIQPLVERREFWIGLNDQHTLGQWEWASGEPVTFTRWKVGSPVPGTHGNRNCVSQNTRFRWIEKKCDNHSQQYVCEKQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A043</accession>
    <name>A0A914A043_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057248.1">
        <property type="nucleotide sequence ID" value="XM_038201320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A043"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201320.1">
        <property type="protein sequence ID" value="XP_038057248.1"/>
        <property type="gene ID" value="LOC119728885"/>
    </dbReference>
    <dbReference type="GeneID" id="119728885"/>
    <dbReference type="OMA" id="LQIAWIA"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="131" mass="15496" checksum="E3F4580A1B77F424" modified="2023-02-22" version="1">MESISSHQQLYFPSETELAFHNLRNRLLREGDSITRRVDAVLGFRVIDCRGGYIECWLIDLRQGRRVVRRANGEKTDIIFHISENDLMELFTGRQQPQKLLLTRRLRISGTKSLQNKIQYLIPDKRRKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1P7</accession>
    <name>A0A914A1P7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057752.1">
        <property type="nucleotide sequence ID" value="XM_038201824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1P7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201824.1">
        <property type="protein sequence ID" value="XP_038057752.1"/>
        <property type="gene ID" value="LOC119729215"/>
    </dbReference>
    <dbReference type="GeneID" id="119729215"/>
    <dbReference type="OrthoDB" id="10135721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013:SF7">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46013">
        <property type="entry name" value="VASCULAR CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="143"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="407" mass="45040" checksum="CAFB55F5B7ED5DE2" modified="2023-02-22" version="1">MVALFVFETCASLHYLEDEHPIGASRFTRTARNVKLPTYLSPNEVILHRGQTQHIRCPSYIKGERVSLVFWFKGEQLLARYTHPKVGSSYASSDRYRMSHSHDLIISHVDMRDQGDYVCSVVPTATALQRRQSISVTVMTDVPSFKEAMDLTEGEVYVHRNQTHHIQCPSYREGESVSLVFWFKGGQLIARFANPAVGTNFISSRRYWMSSSHGLVIYQVQSADEGDYVCGVVPSATGLQRKGSVRVTVLVGSTMESATSGNVDYSDEITHQEITHTVQGNTPLAYDSIALSAEKLPDVSAVQSAVPAVVCTLAVIVLIGICIVVLVKMRQSNMNEAEDSEQKHQDASKGSTHDSKADRSTTPKERATRVAHRTDTEYAAVVDMPQDRPQGSTENYSADRSETCTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A384</accession>
    <name>A0A914A384_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058130.1">
        <property type="nucleotide sequence ID" value="XM_038202202.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202202.1">
        <property type="protein sequence ID" value="XP_038058130.1"/>
        <property type="gene ID" value="LOC119729587"/>
    </dbReference>
    <dbReference type="GeneID" id="119729587"/>
    <dbReference type="OMA" id="EKYLCYD"/>
    <dbReference type="OrthoDB" id="7863416at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 16" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="22">
        <location>
            <begin position="75"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="19">
        <location>
            <begin position="271"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="394"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="933"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="20">
        <location>
            <begin position="1056"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="917"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144279" checksum="CFABFF6D56227613" modified="2023-02-22" version="1">MARQDGYKYEGVAVENFKIDDEPNNTKAFEANGANVKTRQPKSPRFFKLKVVTAVLVALIILIVVIAIVLVFATRDNVKPVFRNCPRQATATVHYESEAENISASWETPTATDNSERVNLTSSHRPGDMFARGTTTNVTYRAVDPSGNEAVCTFLVSVLDCEPDEWRCDDGTCISDALVCDGVPSCADASDESLCDDCLEEDFLSPCDDTKCLPVSFVCDGIEHCDDFEDERYCDDCEENGFLSCNYGSQCFRYSDTCNNIIDCPRFRDEYNCYECASISTSQCQSLLPYNQTFYPNIFSTAEEAIDFYMDFSAIMDCHENLELFLCAYLFPECSKSGSPRYLCSDFCQEVQVACSGPYAGAHDGRELNFFCDRYPETTTGEESKLCRSPFEGCDIRWPTELDLSNGTVYDLYSPSYPMSYPSAFDCRWVFTASPGQYIIFALEDLSINDDSVFMGPGGEVDLDVASYYYRNEVRYGRWLLNITIESDQAWLQLVTGTSNVARGFHFKVFQVDAFNETCGDDEFLCDVGGCFPNTRLCDGFADCYDEKDELECEVCPYYDQVKCGDGSCIHRVAVCDDYPDCDTDEDNCTFLCHEDSSIYLNELLVCDSFNDCGNHADELVNCACVEGRQFDCGERCVPLNYLCDGTNDCADGSDEMNCTCSNWKRPCDDGACLPFWFFCDNSADCSDGSDEQDCPPCPGNYYECDNLECISADGLCDGYFDCSDRSDEAYCVGVFIECPADSFQCPSDRQCVPEQGICDGIVNCKDGEDEVDCDQAIAPQDEACGERQIELTAVDQNFTLTFPEIPGVASSCLWFITSPPDTRITVTKLKDHPTRDRMRVGHGHDPTDEGETLESYDIPVDKALVSKANKMWIKFETELTFLTFDLVLTSIKNVCPEDQKQCLSKYDTCIMSANWCDQKPDCKAGMDEIQCLRLENQGGSAQRKQGVVMVTIEGDEKYLCYDEQTWSDDVADVICNEYGYGFMNETSFEDVSTFGPITDGYYMLHEKEVSKLLSPGPKPALYKIVKHFENCPSQKVIRLSCEEQECGRQGQMPRVVSGRDVLPGEVPWMVSLSHPKRQNVDHYCGGALISNKWVITAGHCVSGFLEPKILAGTVNLTSDDGYEQVRQSKRSIPFPSYINYNYNDIALLELEVPVSISDRVRPVCLPPRNDSHLTAEGSSASVSGWGGTVPFGYTPHILQTARATIINTENCKNFEDISYVNERVVCCMNQYGEQNSCKGDSGGPLTVSDAGKWYQIGLVSRGGTPSCSAPRQVVVYSRLAQFLDFIEKYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3P1</accession>
    <name>A0A914A3P1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057996.1">
        <property type="nucleotide sequence ID" value="XM_038202068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3P1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202068.1">
        <property type="protein sequence ID" value="XP_038057996.1"/>
        <property type="gene ID" value="LOC119729497"/>
    </dbReference>
    <dbReference type="GeneID" id="119729497"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036950213" description="DUF4440 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17715" checksum="F8FDC39D12B9CEB3" modified="2023-02-22" version="1">MSAFTWLCVFLLVGLLNTPIEAEDGKEENRGIADHHVVNEIVYDGYLLQQCVTDKDLDCILSYYAPDVIVVPDGYPSYQGIDQLSKNLGWIQHVTVTKHDAEHIEPLEPSGDLVLEVHAHDTVLPDGSHKKGKTALIWKRIHGLYHIIFEMYNDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4J2</accession>
    <name>A0A914A4J2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058743.1">
        <property type="nucleotide sequence ID" value="XM_038202815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4J2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202815.1">
        <property type="protein sequence ID" value="XP_038058743.1"/>
        <property type="gene ID" value="LOC119730024"/>
    </dbReference>
    <dbReference type="GeneID" id="119730024"/>
    <dbReference type="OMA" id="HIRRRIC"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037088099" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="116"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="39238" checksum="A1A195FF4D6C9566" modified="2023-02-22" version="1">MAKLYASFKVVNLMVFLEVVILVDGHQFHTRQLMYAAENRALQGLAYANKTLRSRVICGRECSMDERCKSFNFHDCNKICELNLATRREHPENFNATQGSVYFDADEDTPLYSLTDSSLNRYRSCKMLLDAGYRSSGIYTINPEGSGNGGLRVYCDMETDGGGWIVFQRRQDGSVDQDFYRNWTEYQSGFGDLSGEFWLGNDNLVTLTSDDSRGTWELRVDLEDWEGNTAWAKYADFQISPGEYNLNIGQYDASSTAGDSLAWHSGSPFSTKDNDNDIMGPYNCAQSRHGAWWFYNCAHSDLNGEYYPDENAAADEKGVYWRHWKGHFYSLKTCQMKLRAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A738</accession>
    <name>A0A914A738_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MEI4L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059680.1">
        <property type="nucleotide sequence ID" value="XM_038203752.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059681.1">
        <property type="nucleotide sequence ID" value="XM_038203753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059682.1">
        <property type="nucleotide sequence ID" value="XM_038203754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A738"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203752.1">
        <property type="protein sequence ID" value="XP_038059680.1"/>
        <property type="gene ID" value="LOC119730732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203753.1">
        <property type="protein sequence ID" value="XP_038059681.1"/>
        <property type="gene ID" value="LOC119730732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203754.1">
        <property type="protein sequence ID" value="XP_038059682.1"/>
        <property type="gene ID" value="LOC119730732"/>
    </dbReference>
    <dbReference type="GeneID" id="119730732"/>
    <dbReference type="OMA" id="RASSEMM"/>
    <dbReference type="OrthoDB" id="6351423at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025888">
        <property type="entry name" value="MEI4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28575:SF1">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN MEI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13971">
        <property type="entry name" value="Mei4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="42158" checksum="A75B7F71DCAEADBC" modified="2023-02-22" version="1">MSDQPPSDVHVASINRLKLAVATAVIRCKASHVTAKEYAQSLGQSLRKNESDWKDQARKLEAELLRTRQELATARLREARQDQEQDDMEWDMDEKESNQGNVALQSSAACPDFAFPTPPSSIPNEQPSQNNLENHLRSSTQFLHSMIRLKSLPESTEYDSLPVDALRTVKDSALRALEYLGSYASSHLHDDGLPWKLMNDAVRGVVKTLEHCTEEEIRREIVQGALELVEKLLELMLHNKRLNDHLTQRQLCCLVVSLATSTILAPLILQRILPHIQAAAAMLRCSINTTSFDPTLYENSFFLLSMMEDILLLSRTAPSVHNRGDHMKRALMEVGEGLDSCLLHISEDFPLFSQQIWRVVNILEWIISTKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A750</accession>
    <name>A0A914A750_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein HIRA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059623.1">
        <property type="nucleotide sequence ID" value="XM_038203695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A750"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203695.1">
        <property type="protein sequence ID" value="XP_038059623.1"/>
        <property type="gene ID" value="LOC119730697"/>
    </dbReference>
    <dbReference type="GeneID" id="119730697"/>
    <dbReference type="CTD" id="7290"/>
    <dbReference type="OMA" id="RGSWDGD"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000075">
        <property type="entry name" value="Protein HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="13">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="12">
        <location>
            <begin position="791"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115095" checksum="DD35B070BD3BF3E6" modified="2023-02-22" version="1">MKLLKPTWVNHDDKPVFGIDIHPDGSRFATGGQGEDSGRVIIWNMAPVRKEEDEKNENVPKILCEMDNHLACVNCVRWSNNGYYLASGADDRLVMVWQMISYGGTSRAFGSGKSNIEQWKCAHTLRSHTGDVLDLAWSPDDAWLASCSIDNSIVIWNALKFPEIISVLNGHSGLVKGVTWDPVGKYVATQSDDKSLRIWRTMDWKEETSIFKPFEECGGTTHVLRLSWSPDGAYVVSAHAMNNRGPTAQIIDRDGWKANMDFVGHRKAVTCVRFNSNIFTRQIKRGNHTKHQPYTCCAIGSRDRTVSIWLTALKRPLVVVHDIFNNSIMDLAWSSAGDELMACSVDGTVCYFQFNCEEVGKQLTNDEKVNLHEKVYGKSILSSGSANLANRIIENPEMLKLQQQQRELREKQASKLKMRATPTKPVVQTPLIEGQPLDVKSQQIETRTPDGRRRITPLYIAPQQASFGIAPKPFPSASQSVFTSPASTNQQAQPSSNVFTEGQSKVTVKTEVVDGVTSIDNSTAPISALDSRFTQKPASETKQQEKTKPPSDSQPTGQVKLASDVSQKPTSVMVEKTVPGAEGGAAAQPVVTNIAAMASAAAAAACAEAALAAASTDPTASVSTPPRGSLSVTPKRKDIALDKPVMKRARREYRTQGRIAAAAAVAAAAAAAAAANTTPSTTTATAGTAAVSDGVIRAPKPPLKIPVPSTPKNCEFIIPQPSGSNEQEVVVELENNVTVSGTTVHRLRGSRDNETVWESILTSRGILITGNSLVVCVSCENQTLNMFTCGGRRLIPACMLPSIVSILQCSSRYAMAITSLGMLYVWDLKRLKAIIRKESLLPIMKGGDVTITNSLVTEHGVPAVSLSNGRSYSYSSSMSCWMLLSQQGDCLSQCSDHHSCQPSQDALQGSGPLTTLHGQSLRAGRQSRGMFHSNHSLKLSSTMSYLENQLSAAQALKSAQEYRFWLLTYVRYLVQEEQEARLRDICSELLGPFYREDVKESLWQPMETGLSKHDLLEEILPIIGSNLKMQRLYTEYKEELKILKEKTSWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9Q8</accession>
    <name>A0A914A9Q8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060498.1">
        <property type="nucleotide sequence ID" value="XM_038204570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9Q8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204570.1">
        <property type="protein sequence ID" value="XP_038060498.1"/>
        <property type="gene ID" value="LOC119731399"/>
    </dbReference>
    <dbReference type="GeneID" id="119731399"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="53258" checksum="9CBFC5B90545D1D2" modified="2023-02-22" version="1">MAIIQTCLRRWHWVVTLATFTLYFLVLGPMFNFSILYLSLQDEFESAAAITGWLGSLSAALARLFSPVTVLLEQRLSKRAVTLIGLVLYCTGLLTTSFVPALGYAYITYGVLSGVGANLTLHSSLQLLLEWFAKGNFARASAIALLGSTGGLLAFSPLLTVLITNYGWRNALRVLSGGIFVVGVADGLLLTDPPTTEDILPRQNRSEDTEQNEHDMQNVRERERERERVDESCEQENEGKEKTELDDAIVSNREGSNTKHDWCEVRRMMQSLELWLWSVANFLTFLGWTFFDINFASYMDGLNLHSNQISYVIMAFAGGEIGGKLLIALLGGRLPFKYLYVVVSSCLLAAVPLGLMTIVKTFAAIMPIAVASGFLRSGAYGVLYAAGAELFLEKYGPSTVMVLTLVPPGFGILVSAPLSGSLFDVTGSYFASLLVIAAIFVCTSAAFLCIPVRRKIRSGGSCYLSASRDQQHELQYPEGQCNQVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB25</accession>
    <name>A0A914AB25_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061080.1">
        <property type="nucleotide sequence ID" value="XM_038205152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AB25"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205152.1">
        <property type="protein sequence ID" value="XP_038061080.1"/>
        <property type="gene ID" value="LOC119731868"/>
    </dbReference>
    <dbReference type="GeneID" id="119731868"/>
    <dbReference type="OMA" id="WRDWIGH"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39575" checksum="A9AA944A8BAE6C3B" modified="2023-02-22" version="1">MATMAKQIFAKELLCIVFAGFSRAILTVSGFETSSYTGQHVFYAAENRALQGFQLERKTVRSRVICGRECSMDERCKSFNFNDCSKLCELNLATRREHPEDFNATQGSVYFDADEDTPLYSLTDSSLNRYRSCKMLFDAGYRSSGIHTIYPEGFGNGSLCVFCDMETDGGGWIVFQRRQDGSVDFYRNWAEYQSGFGHLSGEFWLGNDNLVTLTSDDSRGTWELRVDLEDWENNTAWAKYSDFKISPGEYNLNIGQYDASSTAGDSLARSNGLPFSTNDHDNDVWGTHNCAQLRHGAWWFGGCAVSDLNGEYYPDEHATGNEKGVFWRDWIGHSYSLKTSQMKLRAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB88</accession>
    <name>A0A914AB88_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061155.1">
        <property type="nucleotide sequence ID" value="XM_038205227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AB88"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205227.1">
        <property type="protein sequence ID" value="XP_038061155.1"/>
        <property type="gene ID" value="LOC119731925"/>
    </dbReference>
    <dbReference type="GeneID" id="119731925"/>
    <dbReference type="CTD" id="64081"/>
    <dbReference type="OMA" id="LVECDAI"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="33279" checksum="A3C2FAD190B1027D" modified="2023-02-22" version="1">MASENSAFSGRGRKLPIITVDAFTDKPFTGNPAAVCCLSEDIPDETKMKVAAELNLSETAYLQTLVPGDTFQTASRMRIRWFTPTNEVNLCGHATVASAAALFYVVGNRNDVIRFESLSGEVIAKREGDFIGLDFPLNPPAPEERAPLAELIQACLGTIVPADVRFTMMANQELLLRLPDSENRATLESLKPDIGAMMAAPNADNRVKGVVVTLKGNPDNGAVDADGKQYDFISRYFAPWNGIPEDPVTGSAHTVLAGYWSEQLGKKELYARQCSARGGDIQMKVRDDGRVELLGKATVVLQGEITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABR7</accession>
    <name>A0A914ABR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061183.1">
        <property type="nucleotide sequence ID" value="XM_038205255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205255.1">
        <property type="protein sequence ID" value="XP_038061183.1"/>
        <property type="gene ID" value="LOC119731943"/>
    </dbReference>
    <dbReference type="GeneID" id="119731943"/>
    <dbReference type="OMA" id="NSEHRCN"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383:SF1">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="528" mass="57369" checksum="F2BDD3AFB3BAE006" modified="2023-02-22" version="1">MDGKIGRCFALIIGILVTCSFSIGGRQHRQHLFTTQESTRLAGSAFSEKSAVGSAVRCSALCAKHSRCVSFNYAKVLGLCELNRNTSRSLPGNLEADARFKYYEIMNQVSEIRPTEGTQTTTTQEPTTEEPTTTQEPTTDEEPTTTTQEPITDEEPTATTQELTTDEEPTTTTEETTTDEEPTTTTTQETTTDEEPTTKLEPTTTEPTTAVTTSQGLTTLKPSTTTTQEVTPTNEPTTMVPTTQEQTTKEPTTVVTSSQESATLEPTTTTQEPMPTKEPTMMYTAQEPTTKEPITTMPTTQEPSSKKLTTEVPTTQSLTTAIVTDPILWSCSALRDNGYIFDGYYMIDPDGADGEEAFQVFCSEMTTVGWTTVDHPDSNLDIAVTSDPFDVTIAYYANKDQIQALIGVSTTCRQYLSADCRNAHLWMGKTRLAWWVAEDGAKMDNWAGAATGTKGCSCSGSCAGGNSEHRCNCGAVADQWYSDGGFIVDEARLPVKALHFDNAAPPNHQLYYNLGGLQCAKMSLSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACN5</accession>
    <name>A0A914ACN5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061109.1">
        <property type="nucleotide sequence ID" value="XM_038205181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205181.1">
        <property type="protein sequence ID" value="XP_038061109.1"/>
        <property type="gene ID" value="LOC119731894"/>
    </dbReference>
    <dbReference type="GeneID" id="119731894"/>
    <dbReference type="OMA" id="GAIETMK"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="523" mass="58131" checksum="1E0C070958FC932D" modified="2023-02-22" version="1">MEMLPKEKTLELRRKHIGEACRLWYPTRPLKIVRAKGQHMYDEQGNAYLDCINNVCHVGHSHPRVVQAAAEQMAILNTNSRFLHDTLVQYAERLTRTMPEKLSVCFLVNSGSEANDLAIQLAQKYTGHKDVITLDHAYHGHLQNVLAISPYKHKLLGKDAKKKWVHVVPPPDMFRGEHCKAENPGEAFANDVKVTIDKAHAGGRKIAAFFAESLQSCGGQLVYPPGYFRNVFRHVHQAGGVCVADEVQIGFGRVGKHWWGFQTQGSDIVPDIVTMGKPMGNGHPIAAVVTTPEIAASMGRGGYQYFNTYGGNPVSCAVGMAVMDIIEDEHLRENATLVGDFLRKELLELKQRFKIIGDVRGMGLFIGIELVQDRATQEPAANEATYIVEFLREKFILISTEGPFCNVLKFKPPMCFSMEDACNLLARLSEALQELESFSVEELEAVAKSKQLPVHRQSAKPLLLPVVDVDEDDLISGPSKSNDSPTTLSEDSGLDLSPSREIEDVNDLNANISRPKKRQKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADI7</accession>
    <name>A0A914ADI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061872.1">
        <property type="nucleotide sequence ID" value="XM_038205944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205944.1">
        <property type="protein sequence ID" value="XP_038061872.1"/>
        <property type="gene ID" value="LOC119732428"/>
    </dbReference>
    <dbReference type="GeneID" id="119732428"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="11432" checksum="8372942324EE0AC4" modified="2023-02-22" version="1">MKTSGSAFSASQKLEILADTIGEILGTSGTVRINNSRDHDRQPLSPHAISEKAKKMYRDKAPIDYNLLGSNCEHYMNLSRCDYPTSAQITAAGMAVLKYILAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEZ5</accession>
    <name>A0A914AEZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038062086.1">
        <property type="nucleotide sequence ID" value="XM_038206158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206158.1">
        <property type="protein sequence ID" value="XP_038062086.1"/>
        <property type="gene ID" value="LOC119732588"/>
    </dbReference>
    <dbReference type="GeneID" id="119732588"/>
    <dbReference type="OMA" id="SMYDEKN"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.130.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF0">
        <property type="entry name" value="FUMARATE HYDRATASE CLASS I, AEROBIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="13">
        <location>
            <begin position="85"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="14">
        <location>
            <begin position="366"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="575" mass="63106" checksum="F596D49BD14E082D" modified="2023-02-22" version="1">MLTQSVRRGLLLCQRCLLDSLLHRGKATAAKAAPDVKAFHYQDIMKPDTQFDVPYKKLTGDFVSTFEFKGRKILQVAPEALTALSSQAMVDIAHLLRPKHLQQLSSILDDPEASRNDKFVALELLKNANIAAGMILPGCQDTGTAIILGKRGQNVWTDEKDDEHLSRGIYNAYTQTNLRYSQVAPLDMFKEVNTGTNLPAQVELYATPGNEYNFLFIAKGGGSANKTFLYQQTKALLNPAKLASFVDEKIKTIGTAACPPYHLVFVIGGLSAEMTLKTVKLASTKYLDNLPTTGNEHGRAFRDLDMEQQVLDLCRSTGIGAQFGGKYFCHDVRVIRLPRHGASCPVGVGVSCSADRQILGKINEEGVFLEQLETDPGKYLPEIQLEDLEGDVVKVDLNQPMSQIRQTLSAYPIKTRLSLSGTLVVARDIAHAKLQERLDSGEGLPQYIKDHPVYYAGPAKTPEGYASGSFGPTSAGRMDSYVDAFQTAGGLMVMLAKGNRSKQVTKACKTHGGFYLASIGGPAALLAQNCIKKVEVLEYPELGMEAVWRVEVEDFPAFIVVDDKGNDFFKEWQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFP3</accession>
    <name>A0A914AFP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062557.1">
        <property type="nucleotide sequence ID" value="XM_038206629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFP3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206629.1">
        <property type="protein sequence ID" value="XP_038062557.1"/>
        <property type="gene ID" value="LOC119733048"/>
    </dbReference>
    <dbReference type="GeneID" id="119733048"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37956" checksum="BC717952F50A9BFE" modified="2023-02-22" version="1">MGNAQSHTSEPFTFKGEDVYAKFEKDWFDKGESRYAYRGRIKHVNRWWFERGEQCVVKLYKEEYCNRLKEDAWKADNRASAKAAEMAMLFNNAFTNKGFAKIEVLIPIISKVQTFATYKYLGRDSVAQSVRGPDDDSIATANQMVPEGAAVAIERFLQGRYVHFISNSAKVNKNEKTLVPVAFSHFTYAESNGEILVTDLQGVYNGKNYVFTDPAVHSMEKHGQKFGYYGPTDLGMFGVVKFFQNHECNRLCEGLLKPDMSKIPDYLKGDLDLAIEAIKTRSGSTYTFALLESGLSAQRIQELHTSIAHALTQSGDGQRRHYGLRHGFIDVLSMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGF9</accession>
    <name>A0A914AGF9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063065.1">
        <property type="nucleotide sequence ID" value="XM_038207137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGF9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207137.1">
        <property type="protein sequence ID" value="XP_038063065.1"/>
        <property type="gene ID" value="LOC119733765"/>
    </dbReference>
    <dbReference type="GeneID" id="119733765"/>
    <dbReference type="OMA" id="SKSHYAC"/>
    <dbReference type="OrthoDB" id="6134084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="21095" checksum="9CBE3BDF9FA2A19C" modified="2023-02-22" version="1">MAGTGFGIYDMWTTTSWDENTMGVSGSWRDESLHDAWKSGELNVTRVKLSVRDFEGRRADLIFNGTGTDIHNWFTQERLISSPWEDVKSTTPNYFSTEGFAANGRRFYMSKSHYACTYDRGWLVVKESLVGGDCDWEKNSTEYPSFPLILYSRSTIAARWRVMFYTGDVTVGRADFLTIHVDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AID5</accession>
    <name>A0A914AID5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063301.1">
        <property type="nucleotide sequence ID" value="XM_038207373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AID5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207373.1">
        <property type="protein sequence ID" value="XP_038063301.1"/>
        <property type="gene ID" value="LOC119733990"/>
    </dbReference>
    <dbReference type="GeneID" id="119733990"/>
    <dbReference type="OMA" id="SHHEVGQ"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="112"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="402" mass="44933" checksum="2734D3F9E502C993" modified="2023-02-22" version="1">MADKEDADSIIMRMRNLGARNIRFEISDLFDRSQSTVVPQNKYHELATEGLEFPLPGIFHDTDSTYKSVYHDKIGVLKPDFDSTLFRLPLSDGLALTLAEPHLDGSPLPTYPRHIARKQLDRLGELGFTLKSAFHLEFYLVAPGDSISAELLASFLNTLQGIGMEPLFLKTGKLPNYIDGTYKEEPGIKGADFAHLFKTFMKEATVGRGADVSFFSKYLRDPQFQKNCFLYFRHSLWDAEGKKDLTHDPESPLGLTETAQHWLAGILEHMPAITRFMFPTDFCWKHRSTKTETVNDKWEKDGSGSSMRLHAGGEGKTFVETRQGTGRCNPYLLMAAVVAAGIDGIEKKLPLPEAGAESGKEVPTFHRKASEAFEADEVLINALGAGEDFIKLFKAKYEGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIY4</accession>
    <name>A0A914AIY4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063359.1">
        <property type="nucleotide sequence ID" value="XM_038207431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207431.1">
        <property type="protein sequence ID" value="XP_038063359.1"/>
        <property type="gene ID" value="LOC119734060"/>
    </dbReference>
    <dbReference type="GeneID" id="119734060"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="108" mass="12475" checksum="2BFC838073BF9645" modified="2023-02-22" version="1">MFWHDFGHSDGNLKDLLVVSRTLWRRLAYISSYAECTAFHHDTQMTYPALTKDTFRKFDNFHRFEEFLPISGLKMAKTCIASYNGRALDSSASDLYYPPIAIELLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL18</accession>
    <name>A0A914AL18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064695.1">
        <property type="nucleotide sequence ID" value="XM_038208767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208767.1">
        <property type="protein sequence ID" value="XP_038064695.1"/>
        <property type="gene ID" value="LOC119735075"/>
    </dbReference>
    <dbReference type="GeneID" id="119735075"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037769621" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19295" checksum="C98921401FAF0508" modified="2023-02-22" version="1">MISRYNHLTVLLLIFDAVFSSAAVCSPGWTNWKQSCYAMHSKRLNWMDATKFCENTGSHIVVPNSQAENDFIWGLVMDRLEYASLPMGGVWIGCKRETADSSFVCAEKTDFTNWTPGHPSAKVLCIVYGKGGNGTWRSNRCTNDSRRYVVCEMPNTAYCLTAGKNGRFVSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL26</accession>
    <name>A0A914AL26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hermansky-Pudlak syndrome 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064271.1">
        <property type="nucleotide sequence ID" value="XM_038208343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208343.1">
        <property type="protein sequence ID" value="XP_038064271.1"/>
        <property type="gene ID" value="LOC119734786"/>
    </dbReference>
    <dbReference type="GeneID" id="119734786"/>
    <dbReference type="CTD" id="3257"/>
    <dbReference type="OMA" id="GLVHFMY"/>
    <dbReference type="OrthoDB" id="10255234at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="3">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="4">
        <location>
            <begin position="617"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87782" checksum="1D662884949D8EDD" modified="2023-02-22" version="1">MKGIMVMRNPSMPDIVFLTADKEFVGHMNQLAISKKLTTEQEVDKDQLDISIATHYFSPIVASYASLDNELHLPYASIRTKNDFLFVLKQCDDHLYIAVNGDGSESEVFLQRKLQVLHRLVEFYYGPISDQLRPESVSERQRVWEELARLIDTWTELYGKEQCFLVEAIERLQVNQTVNEICIGALETVLRKFRSVGEKYAVHAMLMVDAKLLALYSSRKASELQSSDILITTLLATSFCHTKERLQNLLTQSMHQYEWPENSTHNQHLSSNSDEYLSAGDGGSDDGSSYYSTNNDSDNGTSEMDTVLRTEVKACPAKSRLLANTEDKGAAGGGTSSDSLSDCEAEFSKEAFFTPPVSASPSKPRSKSLRVQEAYSSKDSKHSAQSLSVAATVSLFGSVAASENLKSDRRDFVRMPAFLQLPNCSCAPHVMQFVPVLPGTTMVIVSQVRVQLAKIISNALYIVNLICQRKSDVTDVQLGFSLRTLPEALENVVKQICEHAKKFKTSGMLKHQSELKECWQHVKRFGLQGYLDTGKTTAVSPRLEAALSEMNRLLKVIFKARYFNVKSSPESVSKQYAEAIKESQYLLRESLFHYQQYLTIKAQRNITMTTYLEDFPGLVHFIHVDRKTDQITAPSLGASDALHEENRGQNPAALVKEKVWSIVPMMHEYLMQGNYTAAVRQGDFYFSYYLYFEDVTGKLVAAQRQIKMEHTDIPGILTGTFFKDLVHRCFPGIPPGFVRCCELLCIHLSVVPIQYVTAHARRLCASLWETSGEVTAPVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALR9</accession>
    <name>A0A914ALR9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064692.1">
        <property type="nucleotide sequence ID" value="XM_038208764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208764.1">
        <property type="protein sequence ID" value="XP_038064692.1"/>
        <property type="gene ID" value="LOC119735072"/>
    </dbReference>
    <dbReference type="GeneID" id="119735072"/>
    <dbReference type="OMA" id="YNCKDIF"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="73"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="229" mass="25939" checksum="94725BC7903B64F0" modified="2023-02-22" version="1">MVCYIGQAPDPESYDSYRWVIPIEDPCGCTEVKLGGVNILTSRRPPIRVKYYDVFLLTKDPEEIWTWLNCTTCRDPLGMESGAIPDSSLSVSDVGHADFSAGKSRLNVEAAWCPVAEDQNQWIRVDLQAPTTVTGLITQGRHYSDVWVTSYKVQHSDDGTNWSDVTGTDGISMQFQGNVDYDTPVTNYFPAVLNTRFIQIRPLAWTRYICLRFELLGCRAGWSHPFEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ98</accession>
    <name>A0A914AQ98_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065601.1">
        <property type="nucleotide sequence ID" value="XM_038209673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQ98"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209673.1">
        <property type="protein sequence ID" value="XP_038065601.1"/>
        <property type="gene ID" value="LOC119735755"/>
    </dbReference>
    <dbReference type="GeneID" id="119735755"/>
    <dbReference type="OMA" id="CEDAGCN"/>
    <dbReference type="OrthoDB" id="10099895at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037654852" description="Protein quiver" evidence="1">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21032" checksum="A5BFF7739E1A4230" modified="2023-02-22" version="1">MSFMFIVLCKLTLLDHGLFGGVMDHDACKSKMTFLLLCASVFILSGKVVFALQCHTCADVNRHTGQASLTCDDFYVKNHTKELLQGCSDPPSGHTVRCTKFGGHAQKMEDSGSSILMDGISRGCVTFKENSLPRSTCYYGKEASPWLSSLVPGTEGASVNGLICFCEETGCNGVASVQPFVSHLLCTLIILYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVH2</accession>
    <name>A0A914AVH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067688.1">
        <property type="nucleotide sequence ID" value="XM_038211760.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211760.1">
        <property type="protein sequence ID" value="XP_038067688.1"/>
        <property type="gene ID" value="LOC119737418"/>
    </dbReference>
    <dbReference type="GeneID" id="119737418"/>
    <dbReference type="OMA" id="GHEANDY"/>
    <dbReference type="OrthoDB" id="10025340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000115">
        <property type="entry name" value="Polyprotein of retroviral origin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="718"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1515" mass="171192" checksum="E08F81688D26143D" modified="2023-02-22" version="1">MPKSGLSSPATLPLRQPLCVLLTVVLAVLLTVLLAGVGLEPKRAIMEKWVEVGKEMGLQGGDLMDFIRERERAAKEERMELRSLKKQEQEILEMRMKVHEAESKPGKEVKPTVTTNTKAKMPKLPSFHDDKDDLDSYLQRFERYATSQKWPPETWAINLCALLTGKALYVSTRIPKDLVNDYDTLKKALFKQYNLTEDGFRVKFRTAKPDKEESPTQFAVRLENDFDRWIDLAKIAGTYTGLKSLILREQFISSCSPELSIFLKERLPTDLDKMAKLAEQFIEARGTTFGQFTHHIKKQPTTTSFRKPESSKPSTAQSRSTTFVPMQERICFVCKKKGHLAKDCRFRGTPMRASSMLVDDGNNSGHPRVSQSDGAGGSHGESTNKHDCNCSDCPRGRETVAFMVSHKLPSLSDCCREDDHVTLRCGHQLPIMSAACRERLTGMPVKEGQIGTQKVSVLRDSGCSGVVVRQSLVTDDQLTGEQRACVLIDGTIRKSPVAKISIDTPFYRGQVEAICMKNPVYDVILGNVLGVRDPRDPDENWSPEKTTGPDLTLAVQTRAQKAADEKPPKSLKVPSCISDVVTAEDLQAAQESDPTLQRCRELAKESELITGKNGHTSHFVKRKGILYRQFQSPAVDNNNIFFQVVVPSKYRSQVMELAHESLFGGHLGSQKTCDRVTTNFFWPGIHSSIRRFVKSCDICQRTYPKGKVKKLPLGSHPLIDTPFQRVAVDIVGPIHPATDKGNRFVLTVVDYATRYPEAVPLRNIETPTVAEALINIFSRVGVPKEILSDQGSQFMSGLMREVSRLLSVKQLTTTPYHPACNGLVERFNGTLKQMLRKMSTERPKDWDRYVGALLFAYREAPQASLGFSPFELLYGRTIRGPMSILRDLWTGETKEEDTRTTYQYVIDLKNRLRETCELAQQSLNKAQIRQKKYYDKRSRDRQFKVGDEVLLLLPTDSNKLLLQWKGPFPVVAKQGSLDYQIDMNGTVKTFHANLLKLYVRRVEAASNEPVEYACVSVIVDGECDEEGDNESLLHSPVLEATESVDDVLIDHELTKQQRQEVRIVLSEYPNVLTDLPGRTTVGEHDIKLTSNDPIRFKPYPLPFAMRDTVDEEVAQMQKLEVIEPSQSPYASPIVLVDKKDGTKRFCIDFRGLNRITVFDAEPLPTPDEIFVSLSHDRYFSKFDLTKGYWQIPMRKEARLATAFLTPNGLFQFCTMPFGLVNAPATFSRIMRRVLKGLKHTDNFIDDILIHTASWDDHVVALRVLLERLQSAQLTAKPSKCVIGAQKLEFLGHVVGQGHLQPQPDKMKHIQEAKRPETKKQLMSFLGLAGYYRRFIPNFAALAVPLTDLTRAKEPNRITWGESQEMAFNTLKTKLSTDPILHLPDCSKPFIIRTDASNTGVGAVLLQERDDTGQTFPVAYASRKLLPRERSYAVIEKECLAVVWGIQKFEPYLYGRQFVLQTDHQSLAYLHRSKLANARIMRWALALQPYRFRVEYIKGSQNVGADYLSRSEVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXW0</accession>
    <name>A0A914AXW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SS18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068523.1">
        <property type="nucleotide sequence ID" value="XM_038212595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212595.1">
        <property type="protein sequence ID" value="XP_038068523.1"/>
        <property type="gene ID" value="LOC119737928"/>
    </dbReference>
    <dbReference type="GeneID" id="119737928"/>
    <dbReference type="OMA" id="MGSAHQP"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF0">
        <property type="entry name" value="IP09280P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="591" mass="64806" checksum="4F992BBB4E694E0B" modified="2023-02-22" version="1">MSLAFVPPRQRGKSVPDQATIQKMLDENNQLIQAIVDYQNKGRASEVAQYQQILHRNLVYLATIADSNQGIQNLLAAPNQSNANMGNPSQGMSGPNPPTMGPGPGGMVPNSQADNMMHQQQHPQQQQQQQHPQHQHPQQQQHPQQQQHPQQQQQHPQQQQQQQHPQQQHLQQQQHPQQQQQHPQQQHQHPQQQQQHPQQQQHSQQQLQQQPPPQQQQQHQPPQQQQPQQQQPQQQQPQQQQQPPQQQPQPQQQPQPQQQPQQQMGSVPASMPQTSSGQMPMGQIHGSQMAEQSSMGPPSSTTNNNMPSYSTSGNTQSMGGYPRSSMPPDQAAPGPQMSEQSIMGPPASSALVGNNMPANPNTPTMPPNPSMQSGYSPSIPQGSSSYSHTSMPQSQGSMMPRQPNMPSNQPTNQQQQQYHMSQQRYPAQQGMMGSSQNGSQGNQMMGGQQPMGGFRQPAQSGPQSYGQAPGYGQQYPPQQGGYPPHNPRQPYSNQYQAPPQQQTGPPGPPPPPTQQQQQQQPGPPPPHQGNYGSYPQGQAPPQGRYGYGQGQGQGPPGPPGPMVPVGPGPGPQQGGGYGGYNQGQYGPGYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ71</accession>
    <name>A0A914AZ71_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C-type lectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069455.1">
        <property type="nucleotide sequence ID" value="XM_038213527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213527.1">
        <property type="protein sequence ID" value="XP_038069455.1"/>
        <property type="gene ID" value="LOC119738621"/>
    </dbReference>
    <dbReference type="GeneID" id="119738621"/>
    <dbReference type="OMA" id="YQIFVIC"/>
    <dbReference type="OrthoDB" id="6336722at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180920" description="C-type lectin" evidence="5">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="7">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26766" checksum="DAAF5F2B94122E1A" modified="2023-02-22" version="1">MMKLIWLSVFIVCVWFYAEACQPGQERFGGSCYQLLTERTTWDQGDAACSEMGAALAVPDSLEEHQFIWEMFTGNVSAGHLWIGCNDREEEGKWMKSSGGGECNFFKWASGEPNGGDSHIDCMQLWRNGNGLMDDTDCAYQIFVICESPVTLAVPTMSCLQRYADARSSSHCLTGHVIKEFSAKGVIACGSACRDEPRCRSFNLRRGGPGELICQLNNVTRNEADVKNIRLDNGCKYFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0G7</accession>
    <name>A0A914B0G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069890.1">
        <property type="nucleotide sequence ID" value="XM_038213962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070229.1">
        <property type="nucleotide sequence ID" value="XM_038214301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0G7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213962.1">
        <property type="protein sequence ID" value="XP_038069890.1"/>
        <property type="gene ID" value="LOC119739133"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214301.1">
        <property type="protein sequence ID" value="XP_038070229.1"/>
        <property type="gene ID" value="LOC119739375"/>
    </dbReference>
    <dbReference type="GeneID" id="119739133"/>
    <dbReference type="GeneID" id="119739375"/>
    <dbReference type="OMA" id="FSASCNC"/>
    <dbReference type="OrthoDB" id="8830353at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="53747" checksum="296DF11759598AC7" modified="2023-02-22" version="1">MDAWKDDVRDWPKLEFQDIYDYFINAPACDEQPNRNFRSISEGINYLNSGWVGTIKHRHHEDGSTVILRGTVRFSQQISSYHQVEISVDKENRTIKSVKCDCIASEGKCCSHSAGLSFKINEAYKKGFIGITCTDRPCLWNRSTQGNVVPDSVENMCDPTSKSTMNSALAFDTDEALKKHLNSPHMCELASIPGTILNQVLTSTQTCKPANSDQPLPVHGHHDVNLECEPCQEIFNNYILLKDHEARKLACQTHNQNSALWTSQRKLRITSSSAASVPKKTETDPTKWIMNHIRPHFLGNADTCHGHTYEATAREAFEHQFETLVETTGLVVNPEESWLGASLDGIVDDNTILEIKCPTERKLERYGGTVRGLVESGTYDVRSREGKYFLRQSSAASGYYTQVQIAMYCSKRPMCKFMVWSKKDYVIADVNFDNEWFEQRLGQLRKFYFKHLLPKLTDSIISRELKIVKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1M7</accession>
    <name>A0A914B1M7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069902.1">
        <property type="nucleotide sequence ID" value="XM_038213974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213974.1">
        <property type="protein sequence ID" value="XP_038069902.1"/>
        <property type="gene ID" value="LOC119739144"/>
    </dbReference>
    <dbReference type="GeneID" id="119739144"/>
    <dbReference type="OMA" id="ETALDYH"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="309" mass="34757" checksum="AD0DF85BD6016B43" modified="2023-02-22" version="1">DATGHTVDDLVNKTIEYLQPNPVSRAMSKVRGQNKGGTKPQQPVGFLGEVMLKNGRELGEDSTFGTAMVEMGESLRQLSEVKGAFDLNVRQNFLDPLDHLKNKDLKEINHHWKKLQGRRLDFDYKKKKQAKAGGSTIPEEEIQFAEEKFHESQELAENGMRNLLESDVEQVLQLQALAEAQLEYHKQSAEVLESLLSTLNERVEEAGSRPKSERKPRSTFNSYSTKRDSSDGDDTDAYPSTVDYNAPVPVTATKERCKALYDFEAENEGELGFQEGDIISIVSKIDENWIDGELNGHTGYFPANYVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2P5</accession>
    <name>A0A914B2P5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative WW-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070183.1">
        <property type="nucleotide sequence ID" value="XM_038214255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2P5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214255.1">
        <property type="protein sequence ID" value="XP_038070183.1"/>
        <property type="gene ID" value="LOC119739357"/>
    </dbReference>
    <dbReference type="GeneID" id="119739357"/>
    <dbReference type="CTD" id="9989"/>
    <dbReference type="OMA" id="CYIHNDS"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033461">
        <property type="entry name" value="WRNPLPNID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15017">
        <property type="entry name" value="WRNPLPNID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Putative WW-binding" evidence="4">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="871"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115219" checksum="4F7F14A4FDCED185" modified="2023-02-22" version="1">MMGKMDKERLYKPVDDWRSMARGRRKKPTIPPPLPPPLQPVSSLIIVGDEKSDDFQLLSSALDTPTNDELLTPLSRLQKYANSDNGFNRQMAARGLLESLRTICDPEDRDAGLDTMLRLSEDQEPMVRAELMEQIPHIAMLCQENRSFFPNTVQDYILPLVVRYLTDSNNQVRKTSQAALLVLLEQELIEKRDIEEQVCPIIIQLSGQGSSEDYRNEAVALMSKVAPLIGKEITLNLVLPQFTELCSDSMFHIRKVCAANFGDICNVVGEEATEDLLLPKFEDLCEDGVWGVRKACAECFMAVSWAVSRTVRSEKLSPLFVKLLTDQSRWVRMAAFQTLGPFISTFADPSVSGVQVVCNPDGTVQIASVVDNSESESDEVPSLVFSETQSSQQSSSSSDQSSGQEPRTYSAMQAVAMEVDETVTGDSGTIILGQDKTGVVPLEADPAAAVRASSNIHQGLGHVEFTPEQGAVLVTPEVPSSYDSFLFWRNPIPVIDIQPEIEEATTEDSSSSSERFTTVAELTLETSKSGSENEQKASPDSGIASPAGTPDSGTGSDGEGSPSVSEQTKEVNGVDESQRDVKDITENVSDLELQNAARQPSEEVDNNANVSPSEESSTSQTLAEAGGMVVHKANLNEAEEVLETVSNICSTHVIGQRVNEKTLTFRNGIVEEEVVPEWSDLDPSSANTSNEMQTPERPQRLTQDVIPAELLDLYLSMTDPSRAQTVDTEIARHCAFSLPGVALTMGRKNWQCLKEVYETLASDMQWKVRRTLAFSIHELALILGDEVTTMDLVPIFNCFLRDLDEVRIGVLKHFADFVKLLKPELRKQYLVRMTDFLTTDNTRNWRFRLELAEQLISLCDMYEPGDVCEHLFPIALTLAGDRVADVRFTAYRLLGVIMKRINTADDQTLRQNFIDGIITRYANSDRWFGRQTFIHLCQNLVEVQSVEDEQFAQNLLPSLLSLGNDSIPNVRITLARLLTQNLLPIDFYQSMANPFYEKMMDVVGQLQKDVDQDVRFFSSYNFSNNLHNKKIDHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3M2</accession>
    <name>A0A914B3M2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070906.1">
        <property type="nucleotide sequence ID" value="XM_038214978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3M2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214978.1">
        <property type="protein sequence ID" value="XP_038070906.1"/>
        <property type="gene ID" value="LOC119739867"/>
    </dbReference>
    <dbReference type="GeneID" id="119739867"/>
    <dbReference type="CTD" id="738"/>
    <dbReference type="OMA" id="DIICERG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="801" mass="91773" checksum="ECD2BDD5501975A9" modified="2023-02-22" version="1">MAAPSRDDMDSEQRRRRKHGMLKMYYGLDDEAGKEATTDPIDIDGAHFDPDVYLARLMREKRLTELVDREVDMVKQIRSLDSDMQTLVYENYNKFISATDTIRKMKTDFKKMEEEMDRLATNMDAITDFSAKISGTLQDRREQITKLSSVHMLLKKLQFLFELPARLKKCIEMKAYSQAVRYYVKARAVLLQYQHMTSFHGIQQDCNEIVNDLRMILREQFSNRESSAKQLAESVDLLLQLKEPPDELCDEFLSHAKEKLDEDLAEIASQVDPALVGTQQPDSTAAMEGTDETRPAEKLMRNIPMDILEFIDSSCNSFLSNISLLIASYKELFVDRQATDSQEQEKLVEVAHAKLAEFVNSRMQQYFTHVDERIKTEKSTVDNSLLVRALDRFYRRLLATDRLVPQLKIIERASAIIAQCGHERALFYFDGLKRHFSECMTDIRQTLCAPRIAGKKDKPDMVDLLNTTTTSVVEQLKVILTNLKAFIASDITFSQTPYFRGPFCQDDVREGLLVAFFRHMYSASRDLCDGVGEKGSTTAPALILVLSRLLLDFESTTISQLLVLTDELFPIDNRRSLTQTSVLCAEAQSAAQTLLNHYVKVQGLQISQMLRKSVETRDWLNTIEPRTVRAVMKRVVEDITTIDSQVGALYEEGIRKAHSSDSSRRALSYSVSKQQQQRMQRSYASSSNFDTSLMSNIQKLFSERIEIFSSVEFSKVSILTGIVKISLKTFLECIRLRTFGRYGLQQIQVDTHYLNLYLWRFVSDEKLVHFLLDEVVGSALHRCLDAVLMETSIVEVICDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3M3</accession>
    <name>A0A914B3M3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038070101.1">
        <property type="nucleotide sequence ID" value="XM_038214173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3M3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214173.1">
        <property type="protein sequence ID" value="XP_038070101.1"/>
        <property type="gene ID" value="LOC119739294"/>
    </dbReference>
    <dbReference type="GeneID" id="119739294"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="16">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="165"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="49267" checksum="89D483A046608EFD" modified="2023-02-22" version="1">MSSGGTLQKAIDIVTKATEEDKNGNYEEALKLYTHGVEYFIHANKYEAHGDKAKQSIRDKCTQYLERAEQLKNYIEKKKDRKKPVKSKEGGSSSKKGKGNNSDSDSDDNPETKKMHAQLQSAIVMEKPNIMWNDVAGLEGAKDALKEAVILPIKFPHLFTGKRQAWRGILLYGPPGTGKSYLAKAVATEANNSTFLSVSSSDLVSKWLGESEKLVKTLFSLARENRPSIIFIDEVDSLCGSRSENESESARRIKTEFLVNMQGVGVDNDQVLVLGATNIPWTLDAAIRRRFERRIYIPLPEEQARTTMFKLHMGKTPCDLTEADYKYLGELSSGYSGADISIVVRNALMEPVRKVQTATHFMKISGPSPVDPSVIVHDLLTPCSPGHPQAFEMTWLNVPGEKLAEPKITVKDLQKSLDHIKPSVNVDDLGKYVKFTEDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3N9</accession>
    <name>A0A914B3N9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 66 member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PQ-loop repeat-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070419.1">
        <property type="nucleotide sequence ID" value="XM_038214491.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070420.1">
        <property type="nucleotide sequence ID" value="XM_038214492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3N9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214491.1">
        <property type="protein sequence ID" value="XP_038070419.1"/>
        <property type="gene ID" value="LOC119739513"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214492.1">
        <property type="protein sequence ID" value="XP_038070420.1"/>
        <property type="gene ID" value="LOC119739513"/>
    </dbReference>
    <dbReference type="GeneID" id="119739513"/>
    <dbReference type="OMA" id="FKMWFFF"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="263" mass="30401" checksum="8D5439BF2E1B4D28" modified="2023-02-22" version="1">MDNNVLDILPNFGVQLPVIPLTFTNLVSWIASFFMIFGGIIPFVPQYMDIRRTENADGFSTYVCLTLMVANILRILFWFGHPFELPLLAQSIIMLFTMMAMLHLCTKVNRIQEITIRKRRFIDFETKHFWNWTYFVDYVIFITVFSILGGVITYFLAGQSIFVEILGFLAVFVEAMLGMPQFYRNFQNKSTVGMSIKMVCCWFSGDIFKTIYFILKQAPAQFWVCGIMQVTIDVAILTQVCYYTNKPPQKVVKIAATENVHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4P8</accession>
    <name>A0A914B4P8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071043.1">
        <property type="nucleotide sequence ID" value="XM_038215115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4P8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215115.1">
        <property type="protein sequence ID" value="XP_038071043.1"/>
        <property type="gene ID" value="LOC119739957"/>
    </dbReference>
    <dbReference type="GeneID" id="119739957"/>
    <dbReference type="OMA" id="DIQHFAN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF301">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM56-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="665" mass="72632" checksum="8D89B0C32B389F7F" modified="2023-02-22" version="1">MEKQKNINPLLCFLCNEKFKRPKILDCLHSYCEKCIKEMQKSNKQRTDNIRCPNCRQITPVGVGGAKANIFLARLVEDAAVSEIVMMRSKSAATAQVSCNVCKKHEAVCRCSECAVFLCAICRAFHGRLPASNGHDVYTLEECRAGKAGGVTGRSDAPECPDHTGERCRFYCLTCRKLICRDCTLLDRSSSEPHEYTSLAAAAPLERHAADALLSRLENKVPDLETSLQVLEEMGPALKKRSDTAKAKVQAVANKIRESLAEEEKRLLKEIRLESQKQLKALKENQNEVSATLNNARSSLKSTRLFVQRSTDTELLWLHPTLVKHLQGLVLKDAPGEPLALSFTESDDDVSLGVLTKENITEAVKADVEKTKGKEKPTSRRVTEKASTSRPKEHKVSSNKENPPPESEDCSNSEDGSNSEDGSDPEEGMMGSSSLSVSNKPSTLTKQPIPTGRDTPADRKELGRQPVGTSAPKKMPASEPARKPKDAVPPSDRILRSSSKANATQNQASSRPANRQQAGISVAPELGQLAEDAVDSPDYGQAASRSALHRPVRDGINPSLIHAAGSAKNPSPMTQPWQIPTRLSHQELDFNCNPNFAAAAGLFASVQQAKDEEPTHPGGDRAQDATVHAVQTHQDYPLITSPNIQRGDIQHFANKYDTDSDDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B526</accession>
    <name>A0A914B526_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071049.1">
        <property type="nucleotide sequence ID" value="XM_038215121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B526"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215121.1">
        <property type="protein sequence ID" value="XP_038071049.1"/>
        <property type="gene ID" value="LOC119739962"/>
    </dbReference>
    <dbReference type="GeneID" id="119739962"/>
    <dbReference type="CTD" id="153830"/>
    <dbReference type="OMA" id="SPWKHFR"/>
    <dbReference type="OrthoDB" id="4752984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16476">
        <property type="entry name" value="RING-H2_RNF139-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="607" mass="68959" checksum="6A53CE943E797036" modified="2023-02-22" version="1">MEISSRQLHIWRFSNVVLRLPSVFILEAIHNLRRGRKIRGTVESLASGWELEPHAVTIGSQFLGYFVVFLLHALPLRMLIKLYKFIVVGLLLLAAHLLSDYSLSRETTVPQSSLVSAVTFTLAEVVISLTCARLMGTKHVWAFAAYTLPQIAKLSGLPLDVQESAHEVAQVLTLTEVTLFTLRHVLVPFRLALIGYKTLQEYSELYGIVSVIFALYNRFFVPMLYLIFWLVLFVHRLYVYYSTKDRRIVGEHWVLVIFAAIADCCESPWSLVGLCYTVSYTAFLVLFLCKLYLKGFSSLGGETFLHRGWTEGITVMLLAMETGLLELKKLERILLLSVLMYIALSSTIQSVYEILDPVLLALAASNNPSPWKHFRALSMCVALMAAPLYLSYMLFVVFEAQLWLMIIVSSCLLTTIQTLGSLTIYLLFMADHRRATPWESLDDLVYGIHAMCHVMEFGIALSVLFYGGMESFHSDYNLFGAAIILIHCYFNVFQRAQAGWQSFLTRRDAVRKINSLPSATKGELSSLRDVCVICFEEMTFAKVTPCKHYFHSVCLRRWLYVQDKCPLCHKSILPEMPQPPQGIEEPREELPWQPHPDLGQGDGMMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5T0</accession>
    <name>A0A914B5T0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071299.1">
        <property type="nucleotide sequence ID" value="XM_038215371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5T0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215371.1">
        <property type="protein sequence ID" value="XP_038071299.1"/>
        <property type="gene ID" value="LOC119740162"/>
    </dbReference>
    <dbReference type="GeneID" id="119740162"/>
    <dbReference type="OMA" id="NDMRTES"/>
    <dbReference type="OrthoDB" id="6111965at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="463" mass="49908" checksum="F53A650579D0E96A" modified="2023-02-22" version="1">MAKASTLRTRHGAEAEPGDSREGGWGVVVVIAAHMSMAIQVGLLRSWGVVYLSWKEDFETNDKETSAVQSIMSSVMSFSGLPAGVLTQRFGCRIAGMIGGGLSSIGLLCSCWVTDIHQFYITAFFTGVGIGICYNSTIVVVALYFKRKYKIANAVACSGLGTGIMAVPPIVQLLLESYGWRGAFLVASAIAANSIALSACYRPNHYLNNNKKSCREHDGLEHEPTREVNKGIHNNKTDFVTLNPKSSNSIVKFIHRLSVTLGFQLFLKSYRLTLQSAIQLQYCMVYVGFVLYLVPRAQSVGVAPSTAAMLLSIFGIGSLLGRLGGGLLVSWRISAEHVSTISLVLAGMSVLLLNFESYYIFAIAAFLHGFASGVFFSIVVVLSRSFIGVRKLAIGVGISQIWVGIGSVTGPILAGWILDTTGGSYQTFFYVGGAICFICAVQMFFLPLLRRVEPGIDILPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B688</accession>
    <name>A0A914B688_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071638.1">
        <property type="nucleotide sequence ID" value="XM_038215710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B688"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215710.1">
        <property type="protein sequence ID" value="XP_038071638.1"/>
        <property type="gene ID" value="LOC119740412"/>
    </dbReference>
    <dbReference type="GeneID" id="119740412"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123583" checksum="9BA8B37DD75B0EDB" modified="2023-02-22" version="1">MMNSEGDVQEESYNMNPVRMLKIKTEPKFEDEIESVWHNMATWLSMQQQMYGPKPLDSLQEDCQTTSATEVKQESENACPSDLDEDELHGDGDYLFVSPESSVLLPMPSQQEDGSSDDDQLAENQDVKPVELSAHAEEQERPRSNPSQHGDGSCDDKQLAENQDVRPVDINVHAEEISGAGMPDPNLLPTQEATPKQQTVAISVANPTTDLNPHPKLRKIYPKCGCVGCTQRMQVPKMKPGIKSKIVKRITCTIDVNASWVQCKDCQKNLLSDTLMPHMFICHDYTFLVPPRRFKPLDLRTNLCENVLAVKLTLKPTCFRQCPVCTTMIAGSDLVYHMLQNHWFLPICPHVNTCKSPFASLACLRHHMSEQHDINKYRYIALDSAFHCLPRGLLRGSSRISKPENSYRQHESPVVVQGLKLVYLNTHPQPILTTIAQEPPSVSTQESPMQQQKVTVPDGNSLASDQGGQQSLTSDLEPDRNTISESTIPNDKGPPPSSTKSPVAKVNKGCEKKDDADQTLASVTPDKGQPIQQQNTAATIQQQNTAATMQQQNAAATMQQWKVTFPDGNSLASNQSGQEPLTTDLKPAKNIMSTINHNGNETGPRSSCKESPVAKAKKGSKKKGNAVQTLARVTPGKDQANWMNCPDCDMNLTDRSLMGHLYVSHDYCLVIPPGESNKPDLGMDQSAWAVKLTNNGKSTRQCRICKNRIDEDSLINHLLHNHHAQLKCPYVHTCKCTTATLSGLKRHIRKCHDDIHKYKAPDNACNFELPPVSSTGSEDTRNKTSESQGENRITTDKCISTPKEMEEDNYTSVDGGAQKRNTNQDHCSPKRKRSRSTKRRKSGSSKKLKKYQTDKESVPEERASDQPSNGGADSNDLPRETCDETLENNTNLEGQLIKEDQKHDGIKSTRNATQQESPSSSGETKASENTEKGNGTAPKCAIPVFEHQTSCKCSYCDLPFTSQEQLLEHMFAIHDCFFIDRQCDGKDKTVAIPLLPEFPEPCISLTCRDCPHILSTRSELIFHMTTVHGYQFVCPMESCCHQQFHCDSGYLLLYHLRSVHNFTVKSNIEVLFKLRDPTQLFQLIQPTQLFQVIEPTQLFQINPNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6L0</accession>
    <name>A0A914B6L0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
            <location evidence="12">Centromere</location>
            <location evidence="12">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071757.1">
        <property type="nucleotide sequence ID" value="XM_038215829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071758.1">
        <property type="nucleotide sequence ID" value="XM_038215830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6L0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215829.1">
        <property type="protein sequence ID" value="XP_038071757.1"/>
        <property type="gene ID" value="LOC119740504"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215830.1">
        <property type="protein sequence ID" value="XP_038071758.1"/>
        <property type="gene ID" value="LOC119740504"/>
    </dbReference>
    <dbReference type="GeneID" id="119740504"/>
    <dbReference type="OMA" id="DQLWDFV"/>
    <dbReference type="OrthoDB" id="6432863at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 12" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="208" mass="23893" checksum="2DCD8D7E844FEF24" modified="2023-02-22" version="1">MASSNLSEVITLIEDRKVLQATQEISRCLEDQSSAKKLTQYGETIQEMKQIETEQKETLKDIIRGYLEMKDQKAACVSRDQSQDAMSPEIAEVQSDKAKSREKLISFQQEVQAVQRELDHLADLQVKLETHRGSVKEQTTEVLPKTRYNVSLYQAATKLTWDFNSEPEEVKGYISTSKDVRPFSLDSRQNSKFFITNYLWDLIESTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7P9</accession>
    <name>A0A914B7P9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071835.1">
        <property type="nucleotide sequence ID" value="XM_038215907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215907.1">
        <property type="protein sequence ID" value="XP_038071835.1"/>
        <property type="gene ID" value="LOC119740564"/>
    </dbReference>
    <dbReference type="GeneID" id="119740564"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433337" evidence="1">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="217" mass="24297" checksum="40911B168E7C1A7E" modified="2023-02-22" version="1">MGWVWPFMLLGVALHLWHCTPVFSGGVKCHPVQINSSDQQVRVTRPVANSNTICWNATASHGENIKATMTSSTADCDQNWNLFSFEGLDFFETFCLERIEVFSPTKMLAVQSRLYSVTVQVQYTFESYVGAPVCRNGDHLCTSNYGSFCIRENTTCICFTDGYCFNYEGECKDVYVGHSNPVRVSEEVGPYSELMSGQVSNKTSCWAVPTLCCSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7T4</accession>
    <name>A0A914B7T4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072039.1">
        <property type="nucleotide sequence ID" value="XM_038216111.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216111.1">
        <property type="protein sequence ID" value="XP_038072039.1"/>
        <property type="gene ID" value="LOC119740724"/>
    </dbReference>
    <dbReference type="GeneID" id="119740724"/>
    <dbReference type="OMA" id="YRSQIFA"/>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343:SF5">
        <property type="entry name" value="DUF4537 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14343">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4537" evidence="3">
        <location>
            <begin position="332"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1426" mass="160033" checksum="CDDCF1CC72A432D7" modified="2023-02-22" version="1">MADALVLRPKGIPTIFGNLEEKSITFLVDASGSMYPYLEIVKEHLIEVLLARSFKQNDTMFNIMEFSSEVIPWADRMVKCTPQTVTVAGEWVKNLGCKTGTNTLDALLAGFADPACEAVHLVTDGLPDQIPEEILQHVAVASEGRPVHAIYLSGGIADVPACDFLASLATETAGTFQSIKLSHKGSIEEVKIVVRSDHAVRRISRSPPTTLDNPPMKSFKVYDVSTGKGIPSTSIKTTLQNLPRSNTITYINESDDTSTKMCSVTTSLDHDPIDQKLISVDDVPTRVIRTDNVQLRYPDLTWETHRPTARLVRRMIANADKTSVTGGVLLQGMRVLARRDKDGYYCLGFVKQQITANHTFLIEFDKEPSSKAQPQLQETAIYDIISYNDASRHSIAAGDKVLAPQGKLQYRYAPGTVLEGLEGRSSGCAADTESLVVSFFDGKTEKILKQASIWIPPQLYERVKLEIQMPITARQYLVNNPNYPIMLPPGYSSRTGVGTGYLAKTSAAQETGYLMGGYDSTFEATDKYPVYVPVYPGDSAAFGFRMPSVRESVVKSEDVHRLIPGTSLTKEDLNRKVMQQLMDNKMIPTMPGVARATAEERQKRASPLQSGILRKSVSFRKEEGEMDSGIGSYTAASAVANESQSEPESEDEDDNLIESGTQTLSLRDSGVGTDYSLLYNYRPDSSLDERPPWQYWNPKSKSSRPSSHKSSKAKAFRETVLSAPAEARVQPISAEPITAFSQSQRQALLDAIDQDIKTDRAQLEWIQRHPHPPLRPPYDPEVDMGPVNRSGAFNTVSNQIKSDRAQLEWIQKHPQPPNGAMRYHGVPAHRKIGSRDIVREAKEKAYLEYRRNQVMHMEAHFSQMEMDARKMKEAKEDRCSASVAVEESLTMRYDTSNLTQVRDTLTSDQIPVSEIAYSDNPKTTNNTLPTTTQSYITDGSRPLRKTQEKLTIRDVVFGERKTLTPPPAPKQEIEQPISGKNDSPRGRIVFNPYVLNKSFSFTPKTSWQVGDRAAPHNGNVLSIQSDSGQNFKTAGVKSLQAMSQHQQKTKTGERAMVKVTKSTMDKMINKDLENSLIAFVNENYHSGVNTEEMLQHMQQMLMNSSQGPKQVPQTRPSNLQSRKGGRERVQHKTAVRTAQSSKEISRSSTAQNVVTETNFSEHRPHQQQFFVEKPLTHYGGIDRQNPRIIQNSVTNNSTTAQHSSSETQKQVCQKSVTQNSFGNSSGKTQTQTVRVVENSQVCTEVKSQTATETITKMATSAIPKQLPHQRFAADVTRRDVQRQRDSEDKLRSIQDAKRSVSSSIARQQQERSNREADREAARVEALRQRTQRREDIASQREKEIQDAITRRQDIKQQRQDDLARRHVQKLSEQNEQGAAREAQKRNEEIRRREYFYNKEQKNQDAKDLRLAVREQKQHDLRSQVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B814</accession>
    <name>A0A914B814_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072124.1">
        <property type="nucleotide sequence ID" value="XM_038216196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B814"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216196.1">
        <property type="protein sequence ID" value="XP_038072124.1"/>
        <property type="gene ID" value="LOC119740775"/>
    </dbReference>
    <dbReference type="GeneID" id="119740775"/>
    <dbReference type="OMA" id="MGKLLQF"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48018" checksum="B3ADEABDAFB4ADC9" modified="2023-02-22" version="1">MESAGRRIQANCKKPTPRSGHVAVTYGGLMLVWGGYTEQLNFSDANETGHQMWYVGDDIYLDGKEVWCYNIEAKVWDVWHTRKSPPGMSGSCAACIGKHMYLFGGYYKNGNSNELYRLDLKTKVWKHLKPEGMPPSPRDKVTCWSYQDKLVIFGGFGPPPYNEDDTNRTDEWQLDPSSFWSHERGWNNQLIVYSTTDNRWSYVKSERHRPCPRAAHAVAVIGNRGYVFGGRFEDVRMNDLHVLNLDSMEWVGSIQPASEDIPTGRSWHCMAPVSDRHLLVYGGYSSGRPTDCKPLNDVWVFDVENHTWHQQKSLPSETRMWHTGVSGADLGEAVVYGGCSNDLLDQDQRSVHSSKCFHFFFSPKSLSRLCAEAIVSDIDVLGSELSFLPTMLHRKIELCLNGRQKDESKNHSYNLRSRSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9Z0</accession>
    <name>A0A914B9Z0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072262.1">
        <property type="nucleotide sequence ID" value="XM_038216334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216334.1">
        <property type="protein sequence ID" value="XP_038072262.1"/>
        <property type="gene ID" value="LOC119740876"/>
    </dbReference>
    <dbReference type="GeneID" id="119740876"/>
    <dbReference type="CTD" id="23383"/>
    <dbReference type="OMA" id="QDAWYLS"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000373">
        <property type="entry name" value="MAU2 chromatid cohesion factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000977">
        <property type="entry name" value="MAU2 chromatid cohesion factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="596" mass="67085" checksum="9A7B543B90E8FEB1" modified="2023-02-22" version="1">MASAPPIPTDSWYLSLLGIAESFRTASPPKIKHCIHCLQSIFHFKPPPRIEARTHVQLGSLLFTHTKNVDLARTHLEKAWAVSQSIPSFDDVKFEAASQLARIHEKQSQLHLAKQILRKAIGISQQSAYWHCLLLFQLAQIHTHEKDFISACELLGVGADYAVVASSEYTRALFLLSKGMLMLIDKKYAEVHPVLSTCGSIIDNYTGSDTNKESLKVYFLVLQVCHYLMAGQVKSVKTALKNLQQSIQTITMLHSDDEPISSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYMDKAQKYTDKALLQIEKLKILDSHSILSAFQLMLLEHIIMCRLVMGQKSLAVQEISQACQVCSQNPRLLTTHGAQLHTLLGLYSMSMNCMESAEAQFTAALASTTQTELWQFASLNLAIVYLRSGNRQQELLTLLERINPEVLPTNSHSLRAASYYVQGLQAFFQARYNEAKRYLRETLKMSNEEDLNRLTACSLVLLGHIFLSLGSTRESMNMVLPAMQLAGKIPDVHVQLWASALLRDLYHLEGDPVRERDGYQMHTSFSQQLLKDHFQSSQQSEHNLIQWTEGPCPIHLLQGDGASSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA42</accession>
    <name>A0A914BA42_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073063.1">
        <property type="nucleotide sequence ID" value="XM_038217135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217135.1">
        <property type="protein sequence ID" value="XP_038073063.1"/>
        <property type="gene ID" value="LOC119741384"/>
    </dbReference>
    <dbReference type="GeneID" id="119741384"/>
    <dbReference type="OMA" id="GVTRWDA"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="360" mass="40453" checksum="2C7F85D52BFBCD89" modified="2023-02-22" version="1">MATLGPSLNNCVSTNSSLIVNDTLITVGDEGRLNSIRWFMVVILATGVLGNCSFLLVVARRESMRNVINVYLANLAIADIILLIVSSIPSLTNTAPHSSKIWGCMFMVITTTSYYSSISTVSLLAWDRFRAICKPIKHMAISSIKRSMKLVAAAWCCSLIYSVIVYLERMVTLKGCKLSGVAPLSNSPIESYKTDNFHPSPSLSDVFLVLPFIVCLSLNCWLYARIIHALRNRFAHRMNRPNQQVPEWIRKICQSRVRITRMLALNSLIFFLCNAPRSVTTISGYIHETLGVTRWDADQNIHVLSTVLFVVNSCINPLIYNLTNTKYRQAFREVFMPSCCSSSRPTQRTPRVVHLHILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAC3</accession>
    <name>A0A914BAC3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073036.1">
        <property type="nucleotide sequence ID" value="XM_038217108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217108.1">
        <property type="protein sequence ID" value="XP_038073036.1"/>
        <property type="gene ID" value="LOC119741358"/>
    </dbReference>
    <dbReference type="GeneID" id="119741358"/>
    <dbReference type="OMA" id="CIVNERF"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="36910" checksum="0DA57BBD52E2C78B" modified="2023-02-22" version="1">MLASLSGLCYIECALQLPGTGASYLYAYATLGEMIAFLTGWSSVAARIVALASIGQVWSAYLDDALGGSIGNATVQFVLGGQEWNAPLLGTHPDFIAGLLILVSGGIISLGTNVFSKANNLFMITTLLTLMLVFIVAMIHADFSLVTEHGFAPRGVGFDEIVGSAINAYAGYAGIESIALAAEEAKDQSKDLLIGLLSALGISILVYMTGVLSVTVLTEYSNIDLKTPFEAAFNDLDGLRWMKYIVAVGALCSITGGALNMSYAMTRFIYPMSRDGLLPSVLSRTNERTKTPLLANLLGTCISVVFAVLIDIKILIQTGSMLYTLETVIIIFAVTILRYRPLTGVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAI1</accession>
    <name>A0A914BAI1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073091.1">
        <property type="nucleotide sequence ID" value="XM_038217163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217163.1">
        <property type="protein sequence ID" value="XP_038073091.1"/>
        <property type="gene ID" value="LOC119741419"/>
    </dbReference>
    <dbReference type="GeneID" id="119741419"/>
    <dbReference type="OMA" id="EYEYPEI"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="222"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="363" mass="41033" checksum="12F09CA447B47F2F" modified="2023-02-22" version="1">MLYCLYTDEEHNSRHNLIVELMEMHNKEVIPKTPVNVSYSLSLFSIDGVDEKDNILRISAFATLLWSDHRFQWDPANYSGVSNVNLQASNIWRPDLRMLYAQVVEADVPLVAHFDGTISYFLPLQIAIPCPFNFKDFPFDVHTCDLRLESWSHPGSAINLTILEDAVSTLFYHRENSQWEVQSFKVNRTVVEYEDYTTTQFITLSYRIQIKRTVKEYTVRFVAPSVITSLLILLCFLIPPLSGGRMVLCSVVILGLLLQLFHLNQTVPIHGSDAPFMAQFLTFSVFLAVFAAVESVVSMNLSSWGTWSGSGNNNSNAHKDGEELVAQPKPNLFLMQLARIIDLVCFVVFTVIFAIGGGIILNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCD7</accession>
    <name>A0A914BCD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073709.1">
        <property type="nucleotide sequence ID" value="XM_038217781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217781.1">
        <property type="protein sequence ID" value="XP_038073709.1"/>
        <property type="gene ID" value="LOC119741860"/>
    </dbReference>
    <dbReference type="GeneID" id="119741860"/>
    <dbReference type="OMA" id="VIMHEEV"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="931" mass="105820" checksum="44B420503A4EAA16" modified="2023-02-22" version="1">MARHHALISRQSNMEDGTEVVITPISPLTGISEPIRRRRSSGSADFTMSRRPPSSRLRQVSIGPQLDRWDAMKTRLGVDSHAQLAEVLLDGMEAIVDGDVVWGTQCSNPTLKNKLASFFKRKGIPALVIPRPTRSASVSKLSTGRKKSPMKLKITLKKVVKGRKGHDQNGHEDEEADEDEDEASDDDDGDVGMQDIARDSDYSPHEPSRHGLKKAWLGRHLKGKHKTRQQRKRQVPKTYNEEDYDIDDADDDEEDVEDVAAEEEAEPEEAKKAGNIETPAKRKMRHKARKKLLIKKLRQEKKEKAKASTKTIEELFGPDAVLKKVYCCRKCSSQLDSPDVMKIHWQTHLAEDDGSNEGSGGKEEDATSRSKDGDSQEMERGGEEVEDEGDGDQEVPADLKNIARVMTRCPLCQKLFSNILAHTACHSNYLCEECGMLFRQRRSLKLHHRAVHELGETGQLPFVCTRCGRAFRWEASLRKHRTLHSQHRQYICQTCGKSFKVQAHLKRHVIMHEEVKPFVCPHCGRRFTELSNMKVHTRVHTGEKPYICDVCKKAYSHKVSLKTHKKKEHGIDMWQLGYITQPVIEFDDEGKETEYSIARRSRRPSANASGKTKKKKKEPSASAEDVTKADQVAQFVREANQEKQLDLNNRVEREDSETSQASQTSQTPTTAPAQVPPQHFIESKMQIPLQHAAYQQQQQQQQHQPVPIQPQIQQQPPPEVHPVQHIHPQHLQISIQHNRPYPHPHPHSHPAESSQQHMDDDVDSDPCSPEEEEENPRMLQAELITNQLRHAQRLQLPENNNLPSQPLPLQLPHSQALQLGPQQQQQQQLPSHTQTQPLPHIQIPGMRQLPPQPHQSNQRPPLPSFETVTSPDRQGHPQYRQGMMNTMPGLDLNALVASSMPYMYWGSQQYQGAPAYIQRSSEENSMESPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCY5</accession>
    <name>A0A914BCY5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin epsilon and delta complex protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073914.1">
        <property type="nucleotide sequence ID" value="XM_038217986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217986.1">
        <property type="protein sequence ID" value="XP_038073914.1"/>
        <property type="gene ID" value="LOC119741994"/>
    </dbReference>
    <dbReference type="GeneID" id="119741994"/>
    <dbReference type="OMA" id="FIPPMKT"/>
    <dbReference type="OrthoDB" id="9906141at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043535">
        <property type="entry name" value="TEDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027996">
        <property type="entry name" value="TEDC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35076">
        <property type="entry name" value="TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35076:SF1">
        <property type="entry name" value="TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14970">
        <property type="entry name" value="TEDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin epsilon and delta complex protein 1" evidence="2">
        <location>
            <begin position="95"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="50842" checksum="59998E35867ADF18" modified="2023-02-22" version="1">MTSSSRSSVGRPKEAINSLCQLMNLCGISGLNPEVFRQAKFNKPEAVAPLWSLLSSLTNYSKGKGVWPEPDASASHQATQSNIVSSTKLAMWSEGYRCRQFYHLPEDMSHGSRELLLACGWLLARTNIVTDLVTQDRANMVDTRHLHLEEVLRSRRQREEMKKMKDTIVDEERQTSHGGKHLVWLVGQCRMKLRRLHLQQRELCNLTHQIHVATEGVTTTTDSSHLSPLEVFILRHAEHSKKYQQILEAKQNRLHICLKWQEQQATFWQWMESVLDAKLQDSSEEAEMTVELHIPNPAHGSVGDPADLVRELEGHTQQLEQLVGDALRDYDFDKVENSKRLRVEGDIKAKLVPVCSSPTPCPSRLDAYQTARFHLIKKKPRTSGGQPCLSKTLDAVYIQNEILRLSELVEQLEKDLAELRSCHRLRMDELALMLPDAICIPPMGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFW8</accession>
    <name>A0A914BFW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074765.1">
        <property type="nucleotide sequence ID" value="XM_038218837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218837.1">
        <property type="protein sequence ID" value="XP_038074765.1"/>
        <property type="gene ID" value="LOC119742679"/>
    </dbReference>
    <dbReference type="GeneID" id="119742679"/>
    <dbReference type="CTD" id="84284"/>
    <dbReference type="OMA" id="VTAVQNC"/>
    <dbReference type="OrthoDB" id="446244at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19482">
        <property type="entry name" value="RecA-like_Thep1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010248">
        <property type="entry name" value="PRK13695.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146:SF1">
        <property type="entry name" value="CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="21109" checksum="98B609C26B7C84D4" modified="2023-02-22" version="1">MATSSSAPCIRHVFLTGSPGVGKTTLIHKAIEQLRQSSLNLHGFYTEEARAGGKRTGFDVITLSGRRGPLARVGQGRGPAVGQYTVDLVSFESLALPELSVKEHGRSTSSILVIDEIGKMELFSQSFVQLVRRLLSQSACPILGTIPVPKGKPLGLVEEVRSRTDVKVFMVTKENRNNLLAEIVQTVTQARAQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGV0</accession>
    <name>A0A914BGV0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074657.1">
        <property type="nucleotide sequence ID" value="XM_038218729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218729.1">
        <property type="protein sequence ID" value="XP_038074657.1"/>
        <property type="gene ID" value="LOC119742610"/>
    </dbReference>
    <dbReference type="GeneID" id="119742610"/>
    <dbReference type="OMA" id="PCHYNVT"/>
    <dbReference type="OrthoDB" id="6228811at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001939">
        <property type="term" value="C:female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042585">
        <property type="term" value="C:germinal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001940">
        <property type="term" value="C:male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044727">
        <property type="term" value="P:epigenetic programing of male pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35678">
        <property type="entry name" value="PROTEIN STPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35678:SF1">
        <property type="entry name" value="PROTEIN STPG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="29928" checksum="497CC3B069F10C7E" modified="2023-02-22" version="1">MVSGATSEKTAKTGRVQPAKSHMKASRDRTSVMERATPFKGRTSLRENYEKSVSGRDQWWRVHIRETPVPGAYDSRNFLADIEERPATYTFKGEGRKKDADRQRKGAVLLPGAYEAKDLGYDLEQTRYTYSMKNTSRAENELPGVKDKGCNVCPTQYPMENYLSCSCEKQPSKHPMFKSASQRFPTIYFQGTKNPPPDRYQSYTPETMHVISSSFKSRTPRFATSHTKVPGPGSYDKTFQSPMPATISRMGRNHGLFFTSAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGW9</accession>
    <name>A0A914BGW9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase Nek8</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Never in mitosis A-related kinase 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038075513.1">
        <property type="nucleotide sequence ID" value="XM_038219585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219585.1">
        <property type="protein sequence ID" value="XP_038075513.1"/>
        <property type="gene ID" value="LOC119743204"/>
    </dbReference>
    <dbReference type="GeneID" id="119743204"/>
    <dbReference type="OMA" id="CPQQVPV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08220">
        <property type="entry name" value="STKc_Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000262">
        <property type="entry name" value="Serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000017">
        <property type="entry name" value="Serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000243">
        <property type="entry name" value="serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044120">
        <property type="entry name" value="STKc_Nek8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="478"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="530"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="594"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="22">
        <location>
            <begin position="647"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="707" mass="77744" checksum="9D50B525364CA2D1" modified="2023-02-22" version="1">MDKYEKIRVVGRGAYGTVYLCRRLSDQKLVIIKQIPVEQMTGEERQVAVNESKVLAMLDHPNIIKYYENFLEDKALSIVMEYAEGGTLFDYLQHRGNALLEEGEVLRLFCQLLLSLQHVHSKQILHRDLKTQNILLNKRRDVVKIADFGISKILSSKSKAFTVVGTPCYISPELCEGKPYNQKSDIWAVGCVLYELLTLKRAFEADNLPALVMKIMRGSIAPISDRYTDYLKRLLLQMLHLDPDKRPSINKVIAEPIIIKTLANVYMEIGRVKCPLKIPKPFVVTNSANSKVQSSNRKDSTKSLSRKSSNLVLNSSSSSLPKLRPLSTVYCWGYGVNTPVRLPLPHSDIQIAQVSTGRTQRVAVTKNGRLIIWESSSVGSDSTMLPGAVDQQYPSFIPRYLEGQSAVTIQHVSCGDMFTACLTDRGILMTYGSGAHGSLGHGDYHDVSQAKIVEELLGYEVVMVSCGASHVVAVTNDNELFSWGRGDNGRLGLDSQESFASPQSVLLPVQSHIASVHCGLDCSLLLTTDKKVLACGSNRYNKLGLDDVGPNKKTNGKVDEMHTYSPVVSSPIHQLSIHSVAIGTAHAALVTDDNVCFTLGSNQFGQLGCETETNTPRIPCRPTFQDDVQITAVACGDMFTVALGSDGQVFSWGKSSRGRLGRQEDHSGIPQKVELNEEEPFTITSISCNHGNTLLATKPCVNQADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH19</accession>
    <name>A0A914BH19_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075185.1">
        <property type="nucleotide sequence ID" value="XM_038219257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219257.1">
        <property type="protein sequence ID" value="XP_038075185.1"/>
        <property type="gene ID" value="LOC119742968"/>
    </dbReference>
    <dbReference type="GeneID" id="119742968"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="123" mass="14248" checksum="4A0586368EF3BAC2" modified="2023-02-22" version="1">MLIQSEKIKNDYTCLWLARCYIMNRKARLAWELYLKMETSGESFSLLQLIANDGYKMGQFYYAFDVLERLDPNPEYWEGKRGACVGVFQQIIAGHEPRETLCETSSKSCATPVTRRWNTSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHG8</accession>
    <name>A0A914BHG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ataxin-3 homolog</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Machado-Joseph disease-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038075539.1">
        <property type="nucleotide sequence ID" value="XM_038219611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219611.1">
        <property type="protein sequence ID" value="XP_038075539.1"/>
        <property type="gene ID" value="LOC119743223"/>
    </dbReference>
    <dbReference type="GeneID" id="119743223"/>
    <dbReference type="OMA" id="KRQAFFD"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000005">
        <property type="entry name" value="Ataxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000018">
        <property type="entry name" value="Ataxin-3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="21">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="18 19">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="388" mass="42117" checksum="68E175018E6FA805" modified="2023-02-22" version="1">MDAIFHERQEGSLCAQHCLNSLLQGPYFSAVDLADIGRELDEAERATMAEGDINSPEYLRFLQQPSSNMDDSGYFSVQVIGRALKVWGLELVPFGSTEAVQANTNPEREKSFICNFKDHWLTIRKLGRQWFNLNSLLTGPELISDMYLGMFLIQLQKEGYSIFVVRGSLPENEADQLLNLIPAVQTQKPRLLTDQIQPQSGSTASTSTSGAGPSGKGVFSLQDLQNALKANQRSLEGGGGAGTSGQSWEEAMKLGMQGHKGIDEGPPEEVDVEDLRRKRQAFFDRQQASSVPPQQPTPSSSENPGIALSSPHPHSQATAGNPSDIQGLEASGGKTNYSGPGAVGRSPEADEETYVNDEQMTEEAMLELAIQMSLGRRQQGEQLQGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHX4</accession>
    <name>A0A914BHX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075878.1">
        <property type="nucleotide sequence ID" value="XM_038219950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219950.1">
        <property type="protein sequence ID" value="XP_038075878.1"/>
        <property type="gene ID" value="LOC119743527"/>
    </dbReference>
    <dbReference type="GeneID" id="119743527"/>
    <dbReference type="OMA" id="ITIYICV"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="13"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="425" mass="46633" checksum="4B6BAA06F6DF595B" modified="2023-02-22" version="1">MKNYQEGGWGWVVLFAAFMAQVFVYGNIKALSVLAETIATEYDTDLWLVGWVASMSLAVQLLLGPVISFLMHVFGCRLVMLLGGVMATGGYLLASWSCTFLQWSVFIVGFAGVGSGCFAYPFLAIIASYFKKYYPIALLVANLGKSCGDMLYGPITQVLLDTYGWRWTMMIICGLTFHLVPCAAVAKASRVKDDRNDYRRIACKDNETDVTSDNSQVESTHCCKAILAAFDFAILTDVHFILITLASCVTGFCFIGWEVYVVPHGIDHDLNPTQSSFLPTFYGIGNFVGKVVAAVVLQTYVINARWFMCIGALCASCSFFADPFLTSFASLAVVACTVGSGIAITNTVKFILYRELASDDQLLSMYSWQGLFVGLSDVMSGFASGWLYDVTGSFKATFILLAGLQFCAFIFVLLDYGITKFKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI31</accession>
    <name>A0A914BI31_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="RefSeq" id="XP_038075938.1">
        <property type="nucleotide sequence ID" value="XM_038220010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI31"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220010.1">
        <property type="protein sequence ID" value="XP_038075938.1"/>
        <property type="gene ID" value="LOC119743600"/>
    </dbReference>
    <dbReference type="GeneID" id="119743600"/>
    <dbReference type="OMA" id="HEGLAYH"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036793116" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="58039" checksum="78118E9DE96399B5" modified="2023-02-22" version="1">MKRYTGRTMIWLLLCLGFAGCTLAQNAQFWNDQAQDTLQKALTREASLNRNVAKNIVFFLGDGMGVSTVTAARIMKGQQAGMTGEETVLSWEKFPSVALSKTYNTNRQVPDSAGTATAFFCGVKTKAQMIGVDDQAVEGDCQSSLNAAVDSVMTDAEKEGKATGFVTTARVTHATPACLYAHSPDRGWENNADIPAAEAALGCTDIAHQLVTLGQNIKVIMGGGRREMIPDNFTDYEYPALTGQRTDGRNLVDEWLASKDAQTSHFVWNLDRFNEVDPENTEYLLGLFESSHMQYEAERTNEPSIAEMTEKAIRILQKDSDGFFLMVEGGRIDHAHHGGFAGYALNDTVAFDAAVAKAMELTNEEDTLIIVTADHSHVMTLGGYPSRGNPILGLYDLGVGTDGLPFTSIGYANGPGGIADRVSYEMFGQRRNLTDADTETPRFIQPAIVPRDSESHGGEDVAIYANGPMSHLFHGVHEQHYIAHVVRYAACLGNKQHCDEYVAPCGSGTSSAPSWGVTMIAVLVNLWMALILPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI32</accession>
    <name>A0A914BI32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038075092.1">
        <property type="nucleotide sequence ID" value="XM_038219164.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219164.1">
        <property type="protein sequence ID" value="XP_038075092.1"/>
        <property type="gene ID" value="LOC119742909"/>
    </dbReference>
    <dbReference type="GeneID" id="119742909"/>
    <dbReference type="OMA" id="WSNAKES"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="129"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="237"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="51049" checksum="0519D407E57E77FD" modified="2023-02-22" version="1">MTGLKGAFLLIVAIALAVQGYLLLEFVIPKIQSKIMRRTISENAIMMSNITRIEGLLYRSGHMKNVHSNNSMPRDVGKSRNMPHPPGQCYHRVQVYNKNGVLTEKRPALKNIVDQSKLEGRTDIRANVTCPKECTVEITIAGDEDRFAGMDAVVXHFMKSLIPNPLPPANLNPDQTWVYFSWESPWSNAKESGRIAKLPVHAVWTYYRGSDIPFPYGYYDAVTPMAKETKSVDEWLQGKTKLVAWMASNCGTTSWPRRDFVLELKKYIPVDMYGACGNLKCMPSWSTKCTVDLVRQYKFYLSLENAECDDYITEKLWNKPLMQGVVPIVYGPTRKAYEELLPPNSFIYIGDYKNMSELANYLKLLDSKPELYVEYLKWQNQGSVRVNQVMHEPYDPSAFCDLIPVIDKVKRGELKRTPVSKSSFPKTCRKPDRSKTSAFGLGKWNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLC0</accession>
    <name>A0A914BLC0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076724.1">
        <property type="nucleotide sequence ID" value="XM_038220796.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076725.1">
        <property type="nucleotide sequence ID" value="XM_038220797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076726.1">
        <property type="nucleotide sequence ID" value="XM_038220798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLC0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220796.1">
        <property type="protein sequence ID" value="XP_038076724.1"/>
        <property type="gene ID" value="LOC119744720"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220797.1">
        <property type="protein sequence ID" value="XP_038076725.1"/>
        <property type="gene ID" value="LOC119744720"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220798.1">
        <property type="protein sequence ID" value="XP_038076726.1"/>
        <property type="gene ID" value="LOC119744720"/>
    </dbReference>
    <dbReference type="GeneID" id="119744720"/>
    <dbReference type="OMA" id="NTSCECF"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18300">
        <property type="entry name" value="BTB2_POZ_RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000202">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="331"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="502"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="689" mass="77487" checksum="B92C3C8C9CCD75BC" modified="2023-02-22" version="1">MPKHAKEKKVKIVLVGDGNVGKTSLCLSYTIDHFPWGLIPTECSLYSCNAVVGGKPFAHSVIDTSNQGERYYQLRPLNYPGTDIFMMLFSVENRSSLESIEGRWLPEIRHHMPDTPILLVATKIDLRGSSQHDCITFEEGFNLAQKHNFAYTETSAVLNTNGKDHAEQPIGYCGPNHEEVDVFHLYFSVRCKSSLANVESRWIPEIRHAMPDIPILLVATKIDYPWSAHRRRIVSCDEGLKVAKKHNVGYTEMTGLLNMNLKDCFEKAVYIADEASKPQKKKGFGRRKQKARPPEQLPPEKPPLDEAPRIEIQTSTIAGDLGKALEQPSYSDVTFIVEGKSILAHKVMLCSASNFFCVVFGLKPPDQDTGSGSKVWNFTWEDINEGKIAGLAGILDVVTSDGSSCDKPKSQVTISEDISYKTFRHVLEFLYTDLPNIPEGASAEDIVALQMASSTFCLPMLDSVIKNLRNVAEFLNPSIGTFLNDQTGQRAKRLFLNNQELSDIRFKVEDQTFFVHKILLTSRCEIMARMFSGVFTESNKEEIRIEDVSTECFLALLEYLYTDHAPIEEGDAVGIMVAADRYGQERLKNLCELYITKGVDVAVANSIAEAHVDVIGLLHTAQMYNATQLATWCLHFISSNFMAFKQRAEFKTLEGENLKYISENRWPPVNYLEELEKYNANCGQKEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLE2</accession>
    <name>A0A914BLE2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077113.1">
        <property type="nucleotide sequence ID" value="XM_038221185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221185.1">
        <property type="protein sequence ID" value="XP_038077113.1"/>
        <property type="gene ID" value="LOC119744962"/>
    </dbReference>
    <dbReference type="GeneID" id="119744962"/>
    <dbReference type="OMA" id="MLVYIFM"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="138" mass="16383" checksum="93D1A2854E3D2950" modified="2023-02-22" version="1">MDSFRSTLFTTLFTILFTTLFTILFTILFTLLFTILFTLLFTTLFTILFTILFILFTILFTILFTILFILFTILFILFTILFTILFTTFFTILFTILFTTLFTTLFTILFTILFTTLFTTLFTILFILFTILITMLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLK6</accession>
    <name>A0A914BLK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="20">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="20"/>
    <dbReference type="RefSeq" id="XP_038076656.1">
        <property type="nucleotide sequence ID" value="XM_038220728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220728.1">
        <property type="protein sequence ID" value="XP_038076656.1"/>
        <property type="gene ID" value="LOC119744665"/>
    </dbReference>
    <dbReference type="GeneID" id="119744665"/>
    <dbReference type="OMA" id="FRGYAFK"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000667">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 20" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="247"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="363"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="799"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="629"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111780" checksum="FE33FBF5125ACCBA" modified="2023-02-22" version="1">MTCCHESCVGGCDGRTNRDCVACRNLAHDGVCVDSCPASTYVYKNHRCIQAAECPHYWKLHNGECIEECPTSFITNITNARYCQPCDGPCPKVCEGRMVVNSVGDAANLAGCTIINGSLEIGIRSGTNIMKEFEKNLGMIEEVTERIVIRMAYSLVSLNFLRRLKRIGGASLENGLYSFYLLDNRNLQQLFDIRNYPNITIGNGSLFFHNNPKLCVSNITTFESQVNFLVPPKSNNFGTNGDQVACSIHKIIVFAKPGKSTLILRWQFETSQISDKRNLLGFIVSYRKAPYKNVTVLDGEDACGTSQWQTVYENPDKTGTMLVGLEPWTQYAIFVRSYLISNTEEGAQSDIKYITTKEKEPGPPSDLMVLADSSSRLIVSWGLPKKPNSNIVEYLVRWQKQELEVNMFSTRDFCREKPPTLVSGIIVKPEEETTDMNQTCQHGCCACPKDKEQLKLEEEEALFQKQFENFLHNHVFIQRPDAKRRRREAPDDALAGTPPAATVLPASVRFNSTTPNLFAPMGTSPAPTQLLFKEQFVANTTVALMDLDHFTEYVVEVLACNREKCGLKMATFGRTLPKPDADAIPPTVMANITSKDPQDRRVKLSWEEPPSPNGIIILHEIVYYKMGTQEGGEPRPEEREANGETNGEGNGENPIGQEATPATEGKPEGKMICLSEARFHQQHGYEFVGLDPGNYSAKIRVISLAGEGPWTEPYMFTVPEPVHEPTSAPDSGLGAMGITIGICVAFVLILVAVIWILVRWRYKKNQMPDGVLYASVNPEYMSTSDMYVADEWEFPRNQLDIICELGKGSFGMVYEGRAKKISPDEDVTTVAVKSVQANASIRDRIEFLNEASVMKAINAHHVVRLLGVVSKGQPTYVIMEYMAQGDLKNWLRARRPENQTDVPLQNRKYPPSLTDILNMGAEVADGMAYLTAHKYVHRDLSARNCLVSEENTCKVADFGLARDIYQSDYYRKEKGGMLPIRWMAPESIRDGVFQASSDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMN2</accession>
    <name>A0A914BMN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077001.1">
        <property type="nucleotide sequence ID" value="XM_038221073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221073.1">
        <property type="protein sequence ID" value="XP_038077001.1"/>
        <property type="gene ID" value="LOC119744882"/>
    </dbReference>
    <dbReference type="GeneID" id="119744882"/>
    <dbReference type="OMA" id="TQPYESP"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16676">
        <property type="entry name" value="FOXO-TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="330"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="588" mass="65050" checksum="4A37AF5EF590D17B" modified="2023-02-22" version="1">MADIDPDFDEPQARPRSCTWPLRRPDFLKKPSGPQPSSGEGTPAAVAEEIQDPNLPVQQVESPDIKQDLAAVATNRKNCSRRNAWGNLSYADLITKAIQSAPEQRLTLSQIYDWMVKNVPFFKDKGDSNSSAGWKNSIRHNLSLHSRFVRVQNEGTGKSSWWMINPDAKPGKSSRRRASSMDTNNPKWEKKRGRAKKKVLEERAKWSTSPTPKFEGEPENSLSLALSSEFRSRASSNASSCGRLSPINQIDDMHDNEVPPMSPVPYDLGHHQTQPYESPDHLHTDQLTSLAQAMSLNTSLNGSVSSDLNSPVEQLRVPTPMRPSPKHTSRGNLFQNNVTSNSNSYMTFSPAPSYSGSDRSPVHSNVQSPAYSPYGQNSAMSPIPQQQRCSPSMSVTDMSQQFINIPQPQPASFSMMPHQDTSMTTNGAILSKRDPMLSHSTLQPGSMMHQRPTNLQPTCRVQTNMAQGRSLQGFSPQTSPSNPLTSMLQLNPVITAAQNNHMSSPTHAAMNLQYTQSSMTLPIQSIPMNSSNDKVPSDLQSLDVDMFKGMDCDIDSVIRNELMDDGNLDFNFEGLINQTVTSTPSWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNV2</accession>
    <name>A0A914BNV2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear export mediator factor NEMF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077635.1">
        <property type="nucleotide sequence ID" value="XM_038221707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221707.1">
        <property type="protein sequence ID" value="XP_038077635.1"/>
        <property type="gene ID" value="LOC119745387"/>
    </dbReference>
    <dbReference type="GeneID" id="119745387"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="9">
        <location>
            <begin position="509"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="906"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="130639" checksum="60DD5819CB1A312D" modified="2023-02-22" version="1">MKSRYTTIDLRAAISELGVRLMGLRVINIYDINNKTYLIKLQGTDKKEMLLIESGIRINSTDFDWPKSNMPSNFSMKLRKHLKSRRLNQLHQLGMDRVVDMQFGSDEAAYHLIVELYDRGNIFLTDSEYTILNLLRTRTDSEDVRFAVRETYPVEAAKKPEPLPEPNRLQEMLATAKPGDPIRKILNPHFVFGPAVIEHCLLRQGFPSSVKLEKEFSSKTDIPRLLLALTEAQELMEQSGHSQNKGYVIQKREKKPTAVEGCDDTELLTYTEYHPFLYEQHKSSPHIELDSFNKAVDEFYSKLESQKTDMKVLQQEKDALKKLENVKKDHEKRLDQLMKAQEIDMRKGELIEMNLPLVDQAIKVVRSAIANQIDWTEINNIIHEAQAQQDPVASAIKNLKLDTNHITMVLRNPYEDQQEEEGENSQESSRKQKKKDKANYVDIDLGLSAYANARRFYEQKKFSKKKEQRTVDASEKAIKSAERKTKQALKDVATVASINKTRKTYWFEKFYWFVSSENYLIIAGRDQQQNEIVVKKYLSQGDIYVHADLHGASSVIIKNPTGGLVPPITLQEAGVMAICYSVAWDAKVVTSAWWVHHDQVSKTAPTGEYLTTGSFMIRGKKNYLPPAQLMMGFGFLFKVDDSCVWRHKEERRVRGIEEDGMSLADSSTVDGSVDEEIQLEGDSDDSSEKDGSEGKEKTSEQDNQAGPAVEDLEEQEEVEDEDGSEPEDDQAEIDETRSSSDEDVAYPDTAIQLHHVQGAKLEPERSRGSSVLSTGSYHSNEGETEMKIYLGDDQPILIAANKQSDKQMPKQYLSAKQKRQLKKQKRRPNADTNDDEEEIDRKEEPENEEVISEDAVRTSGLDTKEEYEEKEETEEQEEDKEKEAMGAQPQQIKRGQKNKLKKIKQKYKDQDEEERRLKMEILASAGAPKELRGKKAKQARKQQLLEEKHQQMKQKQQQKRKNQAGKAHGREDMGETEGQLEEKMKGLDVTSEQGEDRVLPVGFKHAWKSKKETVEEGTGEVSDEDKETSLQDEQSQLMKESSNIVDSLTACPHAEDMLLFGLPVCAPYSVMHNYKFKVKLTPGTGKRGKAAKTALSMFQFSKETTNREKDLFKSVKDTDLSRNLPGKVKVSAPNLQKTKTKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPG9</accession>
    <name>A0A914BPG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-tyrosine phosphatase receptor IA-2 ectodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077387.1">
        <property type="nucleotide sequence ID" value="XM_038221459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221459.1">
        <property type="protein sequence ID" value="XP_038077387.1"/>
        <property type="gene ID" value="LOC119745236"/>
    </dbReference>
    <dbReference type="GeneID" id="119745236"/>
    <dbReference type="OMA" id="CRFSPVC"/>
    <dbReference type="OrthoDB" id="10678495at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2470">
        <property type="entry name" value="Protein-tyrosine phosphatase receptor IA-2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021613">
        <property type="entry name" value="Receptor_IA-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038112">
        <property type="entry name" value="Receptor_IA-2_ectodomain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11548">
        <property type="entry name" value="Receptor_IA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037333900" description="Protein-tyrosine phosphatase receptor IA-2 ectodomain domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Protein-tyrosine phosphatase receptor IA-2 ectodomain" evidence="11">
        <location>
            <begin position="468"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="569" mass="63187" checksum="776E2602D5546242" modified="2023-02-22" version="1">MDTSLFLLVFLLASPVPSLTDPSGKLGCRFSPVCDEDEVCAEDQLFGTCMQRLANFLPNYKLDPAGLKQLKDVVQYLLDEGFAWEDQYAQDSLREVLDPFRQSIVPVAPELRPPGYQPESPMTDAEAEAWATVDRLAQTYQAVLDEYQERYRAYEELVKTYGFGTDDDLNQYAAEMQRKYESVVRELQAEERENLRRLYNLYYEKYLSLLEEETNQGATDAQDAWDIEGGYGEGNDWKGLYKMRLLKEYLQLLYNENRDRWVTSSEESASESDTSSEGSSYSLESFMEEWNGDFGNELPVGNDEVAVETEAAEPQDQNKQGEGTVYDTIFGDLDGQYWNALTDEEKNDLIDEILQLEAEDAGVATETGDAEEEGGGKEEQGAESGEEKGADEKKAPSSKGQGVGQPGKEFVEPLQQPKESGISMNVDLAKKDEDAVAVATPEPARKEPTTPAPEPTTAKRTTFAPSGYVFIALTSGISLREAQMLVEELAIALDAPEGAFSEIETGEKQVTFKVHPDVIRMTPAEVAEAAAARQSDLEDMMGVTITETGVGKQVSQFCFGGENCVRNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQE8</accession>
    <name>A0A914BQE8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078528.1">
        <property type="nucleotide sequence ID" value="XM_038222600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222600.1">
        <property type="protein sequence ID" value="XP_038078528.1"/>
        <property type="gene ID" value="LOC119745923"/>
    </dbReference>
    <dbReference type="GeneID" id="119745923"/>
    <dbReference type="CTD" id="27249"/>
    <dbReference type="OMA" id="PECCGMI"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="36692" checksum="803E029321743C23" modified="2023-02-22" version="1">MSKNPTVFTETCKVGADKLTDIVVDSQSSLPMTHRPTARMAKLLSRTRLVSYLPGLKSLQQRAALVCAPRAGFSCSSAGNEPNAEDVQFEARSSGISDADLGPLGPPNHQFPLPGNTGLASQANASFVPVAREAVPDILTKALPQDRHASILAQFVNTVSEEHDLPGAKTDKESFKNHPQALECIAQDCPENLRKEFLGLFPGVQMGSSDKLTVVTLCQRTKNNMTGWSNEVEEERNELMDNFFESAKEMCRVLSDAGYWADFIDPLSGQAFLGDPNPNTTLLETDERFRSLGFEIEDLGCCKCIRHSEWGTHTFVGTIFTSAPPDSKLISSILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BR69</accession>
    <name>A0A914BR69_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NXF1/2/3/5-like leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077997.1">
        <property type="nucleotide sequence ID" value="XM_038222069.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222069.1">
        <property type="protein sequence ID" value="XP_038077997.1"/>
        <property type="gene ID" value="LOC119745593"/>
    </dbReference>
    <dbReference type="GeneID" id="119745593"/>
    <dbReference type="OMA" id="YLTWHKV"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF4">
        <property type="entry name" value="GENE 29133-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NXF1/2/3/5-like leucine-rich repeat" evidence="3">
        <location>
            <begin position="166"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30988" checksum="309037CCED19A866" modified="2023-02-22" version="1">MSEELEEGSSSLQSSSDANAYIAVTGTNIPIITISTHAETEQKPAKLPKLPSNRYRYTVWHELNSNEIKGDELNXPPVRRGPEIKDKIFYSVTDEQGRGLHHGKKGQEKKDYERKIENWENSLTVNLSYQELGDRYQVESFMRILKRLIRAEKIQLINNNLEDLSKVNFPSCVVLNLNTNYLTSFTKLPKCPNLKTLLLCDNSIKSLDGLQNLRKTHLAVLDLRRNPICFQEHYRQRVFQILPDLQELDGIPRLTSDIEGDLIPQGGCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRX3</accession>
    <name>A0A914BRX3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078262.1">
        <property type="nucleotide sequence ID" value="XM_038222334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRX3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222334.1">
        <property type="protein sequence ID" value="XP_038078262.1"/>
        <property type="gene ID" value="LOC119745752"/>
    </dbReference>
    <dbReference type="GeneID" id="119745752"/>
    <dbReference type="OMA" id="MMHYKEE"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11772" checksum="A3EE4B1C72549F8D" modified="2023-02-22" version="1">MTSFRPADSKREEYRKYLEKAGVLDSLTKILVSLYEEPEKPNNALDFLKQHLNVAGPETADVEALRLQVSELQQKVEQLQDENKELRAKLQQENPDEGQGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTB1</accession>
    <name>A0A914BTB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079449.1">
        <property type="nucleotide sequence ID" value="XM_038223521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223521.1">
        <property type="protein sequence ID" value="XP_038079449.1"/>
        <property type="gene ID" value="LOC119746541"/>
    </dbReference>
    <dbReference type="GeneID" id="119746541"/>
    <dbReference type="OMA" id="QSYCNGL"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036788153" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="169" mass="19462" checksum="FB7C814C6C1F6D23" modified="2023-02-22" version="1">MGRWLLVLILCSAVSLSLIEAAPPRKPLNRYCCPHFWTLRGNRCYRFIGKTLDWHGAQSYCNGLDHKANLVSLNTEGEAEFVHHLFKEKGGGLYTHYWTGLSDIDSEGNYKWVGINKPMTYSNWNTRQPDNAGHNEDCIEVVTHSGYWNDIHCTDRQPFICERPQPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2H7</accession>
    <name>A0A913Z2H7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045201.1">
        <property type="nucleotide sequence ID" value="XM_038189273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2H7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189273.1">
        <property type="protein sequence ID" value="XP_038045201.1"/>
        <property type="gene ID" value="LOC119719783"/>
    </dbReference>
    <dbReference type="GeneID" id="119719783"/>
    <dbReference type="OMA" id="NCETERI"/>
    <dbReference type="OrthoDB" id="9978656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 17" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="14 17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="945" mass="106666" checksum="E407CD2747500D51" modified="2023-02-22" version="1">MPRIKVKPAQHEDTLPFTVALDSATDSFSHFQTEESGEKEKQPVKSKKRARVSPCQTVSDFALNVSTAHGLPNIFRAKTKLGRLTWSLIFFVGIVVSIWQGTLIVVNYLNFQVTTEVKIVTHSSLEFPSVTVCNTNKLRLSAISRSRHRQMLVVDHDVSLPYYAPCVGDDFLCRDRPVCIKRYLLCDGIRQCGVNDTSDEDDCDYDFGSCADDEFRCVYSGSQSGLCIHKKRECDRNKDCYGGEDEDDCECKSSEFKCEKHGGCIRKTSVCDGKSDCIDGSDEKTCMPDGNFQCDDSSFRCVSTDTCIPKTYVCDNDNDCADGSDESITACAQLTTTSAPFLCDNDRFSCGDGECIPSSWRCDSEADCANGLDESESHCAPSSRRRRSTGDQPTDSPSDLVRQAHPGNHSNPTYSFFCLSGERVPLWQTCNGFPDCYDGSDEWAANCSDIVSECGINEFQCRERTQEGTVTCIPKSYVCDDYPDCLTGQEAGEPSHTPSDESACATADETLPADYFRCANGHKMIHKYDVCNTVPDCFPEKDDEYACTWENRTSGEVPDPFESPLWYQKYAPLVRKKYHYLFDDFSYRWRPFDRVKGEDPPDWNSFVTYSATPDYSDLVEVPKLSQDEVHQFGHQKEDFILQCSYEETKCNLSDILEFQDDTYGNCFTFNPEGFFATSTTSSRYGLRMTLFLEQSEYISIFGQEAGVRVAISPPGIRPNPTHHGFTVKPGTVTSIGLRYNFVNRKPHPYGKCQTSVENSPIIEDGVVREIRETEQYDRGLCKKSCLHRHILEQCGCSDTLELAGPRCEILNTEQDVCKQLMYFLHQSDNLTCHCPQQCSEVYYTKTSSTSAWPSANFMKHLLKNLHSINRKTKHLNGNNIDKNIVRIEVYYEELNYESTKEEPAYQPSSLFGDIGGIMGLYIGFSFITVFEFFGVIYTLIKNAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2X7</accession>
    <name>A0A913Z2X7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046062.1">
        <property type="nucleotide sequence ID" value="XM_038190134.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190134.1">
        <property type="protein sequence ID" value="XP_038046062.1"/>
        <property type="gene ID" value="LOC119720462"/>
    </dbReference>
    <dbReference type="GeneID" id="119720462"/>
    <dbReference type="OrthoDB" id="5966313at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF57">
        <property type="entry name" value="FIBROPELLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2074"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="136"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="502"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="641"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="685"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="727"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="769"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="810"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="893"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="932"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1480"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="1519"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="10">
        <location>
            <begin position="1890"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="2002"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2042"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2044"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1469"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1508"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1549"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="2011"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="2030"/>
            <end position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2212" mass="238220" checksum="F71A37C682132585" modified="2023-02-22" version="1">MNWNENLLPNDNVIQGFTCGQYGNKFYLNVPSYSRFRPGSVVGNTGMYGRWVQRLDSLPDNFVNPRLFCRNWYSGQVVNRSSSSLGEYRLSTPTPSPTPDNQEVLPRYYCCQASTLCHLYDDYRPAMGCYNYRPPWWFWFWGDPHIKTLDGVEYTFNGLGEYTVALIEDENGAQIFELQGRTQRATNVETGQLTDATFYSGFAAEYSGEGRVEVKLNKRQEADDLITTVNGDVVTPTTAGLLIGNVTVKRDASTNKVVTMFPGDIQFTVGVNNSIGDITVQLGQTYRGKTKGLLGVWDGDQGNDATRRDGTIQPATGDNGAMIERDFYNFGETWRITEQDSLFYYVGDETWALSNDHSFLPSFYEDLVAAATPEKLQKAQELCGDNKMCLFDTLATDDESIGQSTVMLNEMNSETESAATNYPPNITASDTFRVTVGVQFTEQLEAMDPDEDDVIFSLVEPIEGASITEDGGLFTWTPADQSKVMVAFLATDGKANTTHEPTVQLCDCKNGGTCLWDEFVMGTDVVENSFGVVLCECEPGWSGEFCEVDYDACEDGPCFMGVACFDEAPPSLNNTCGPCPEGLEGDGRFCQDIDECELYQDEPASSGGRGCDQICNNTLMDYNCSCESGYSLYIDNRRCIDIDECELGLHNCSVNAVCNNTKGSYECECKPGFRDDFMDGTSCTDLVECTDNSSYTCDEKAKCENTIGSYLCVCIAGYEGDGKTCQDLNECARDMDDNCHAEADCTNTVGSYTCACGDGWTGDGTNCTNINECAAPLPVCDENAECTDTQGSFLCQCNTGYVGNGMMCADLNECTTGQDDCLAVTGECSNTVGSFDCSCKDGYTGDGRTTCTDIDECQGSNDCSENANCTNTVGSYQCDCVTGYTGDGQTCTDIDECTLELDNCQQECFNTEGSFDCNCSAGFTLQDGVCQDIDECTSLSDPHRCGANSMCANLAGSYECRCYPGYTLNSDQRTCSDVNECQAGTHNCDAMSQMCVNDEPYFTCDCKPGFSSEIFNGSCSDINECLNDTLNDCHIDADCLNNNGFFTCQCKDGFTGTGQLCFDIDECSLPTDDPNYANCSRFASCTNLAGSFQCNCNTGYEGDGQTCQNINECESGISACATNSTCTDNQGSYLCTCDDGFRGDGFTSCVNINECQENPGVCHSLATCTDTEGSYRCDCNQGYQGNGTYCEDLNECMTGSDECAANIAKCTNNVGSYMCSCVDGYVSAGFPIGRQCDDIDECALNLDTCDTSVSLCNNTIGSYMCDCKEGYEKNALSQCEDVNECDDTPCTMANSMCANLPGTYECNCMLGFYQQGATCLAAYSKEVSAVFEIISGLVVDSAGFDLATGSVTYRQDLKTSMEAAFGDSSLSSSFRDVVITSLTLNSDSTTALLKLVINFQSGSMHSDLDVIMALLAQLTGSNGGQLAPNHQLIRRTFIIGVPKCDSAPCENSGECVEDNLATGGYTCTCPTGYSGQNCQVAPCDVNPCMNSGNCAVNSSSDTGYTCTCDQGFSGPRCETLAPCQMGNDCVNGATCVNDLNNPRGYTCSCDVGFMGENCEIACTLSCANGGTLDLAACTCTCTDNWSGLSCDDCTLDCMNGGNLNQPTCQCMCENAWMGTTCTDCGLTSCPPGEDLFNSTCQCSACPFTCFNNGVQEQNCQCTCDSDQNWTGDDCSECPLQCANGAELKSQTCKCSCTGNWMGTTCSECQLNCANGGNLNSGTCQCTCAGSWTGTTCSDCPLSCANNGTLNDGACQCQCDKNWMGITCTDCNLSCENGGTLKTATCHCSCAQSWTGANCSELTCLFVSECPLSASSCSNGGTFDAEFCQCLCPSDYAGPTCIAASPCLLDTALCPDTDGKFCQPATSAAGYTCKCNGFAEYFTNSDGSCSKRTSFRFGMAFDLPFLSAYRNPSSASWRKLARRITSAILNKLRGDSLTDRVIGVTVLSLEEGSVVAQTALAFQGQQPSVDVISNVIAENDTLYDGVDDIALVPDSVSYTNTSLLSDCTQDGCMNGGTCESSGFSPQPTCSCPASFTGERCETAVTTSPPDLTTETPPDLTTETPATEGGGGVSPLATVLIIVGCVVLLLVIAGIVIWCCMRRQYLIKSQIYHQSSRRLQANREPFGFEDRRDRSLSSDESYNVADYSEEERRMNRLAHVMSRSPYLQTMQSHSEFIRPYMVTGNEALERYREEEARDGGDVAGRVVYNPALYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z368</accession>
    <name>A0A913Z368_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase PPP1R11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045446.1">
        <property type="nucleotide sequence ID" value="XM_038189518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z368"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189518.1">
        <property type="protein sequence ID" value="XP_038045446.1"/>
        <property type="gene ID" value="LOC119720019"/>
    </dbReference>
    <dbReference type="GeneID" id="119720019"/>
    <dbReference type="OMA" id="MSHMHSS"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="117" mass="12699" checksum="F7EC6CD2D852E2D3" modified="2023-02-22" version="1">MSSSLPTPGVTSTLTETQSQRSPSVTLKLKKPKSDKKVNWKNGVVDNEHMGKKKSKCCCIYEKPRMFGESSSSDDSDDDDDCKMCRHQRKGNYEKPPPEGAEQGGAEQGGADSGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z424</accession>
    <name>A0A913Z424_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046583.1">
        <property type="nucleotide sequence ID" value="XM_038190655.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190655.1">
        <property type="protein sequence ID" value="XP_038046583.1"/>
        <property type="gene ID" value="LOC119720804"/>
    </dbReference>
    <dbReference type="GeneID" id="119720804"/>
    <dbReference type="OMA" id="FSYRICG"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038124356" evidence="14">
        <location>
            <begin position="25"/>
            <end position="3258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="16">
        <location>
            <begin position="202"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1167"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1487"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1658"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1834"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2011"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2178"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2363"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2540"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2896"/>
            <end position="3011"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="3130"/>
            <end position="3255"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2896"/>
            <end position="2923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3258" mass="354371" checksum="8A3957203D7A26A9" modified="2023-02-22" version="1">MAPTNYGVAALAVVLFYVASSSYAKPLTQSMELSAADRVHYFGQAEVQDFELVSPQVSKRRRRGKHIEAKKVVFEAFDERFDIALEPKVGLVDAGTLVHEVGKDGKTVLSQPKEYCLYVGKSLDHKDSTVSASDCGNKLQASIATDKAAFQLQPLKTEHKEKDGPTHMVVRRSVNTQACNMDAERSLESTMSRRKRSTAEPIYVDASVVADDLMYKTYGNETNNYLLTILNQVAELLKDPSLDIQVNLKISNIKIVKTPQLDLSLSEELEKSLESFCSWQKKSDSDISILITRRDLVSGGNHKVTGKAADVGGACDPKRRCLIGQDHGPSGLIFTLAHEIGHSLGMYHDGGLSDCANKKNIMASVNSGGPEAFRWSECSNNDLLNFLARPESKCLKNKPKSLPDYTPSSIPMPGFYFNATEQCAMTYNAKSTVASEVLNKKEICTALVCKNGNGIPESTNVPPLDGTRCGTKRDICIHGECLKVYSTMDCDGGPCIPFWLAGSYTCQNSTSCVATRSVLCVEEHDDGTTRRVLDLTRCPNEVPTDTGICPDDPCRFSFITGEYGTCSVTCGTGLQVRNVDCQDRSQEIPTTVNDALCQEAKPLTTQVCILPACPVNSYSYAVGQFLECSVTCGTGVQLRSVTCQDNVGEAVAEVFCIQLGLFRPSTTQNCDTGISCGLRYVAGPYATCSVTCGSGTRTRMIYCVNDNNLVVALARCEDAQLEELPLTTSCDQEACPSPVYTALRGSWSECSVTCGLGTETRFVACRNNDVDVDVQNCIDAGLTDLETLRVCTRPTCQPEYRFEAGAFSDCSVTCGTGLRIRDVQCLDQDDVAVAIDNCLAIGLTPPPNTMECTLEDCPTYIYQVGEFGACTEECGDGLQLRAVVCVNNDTKAVVDDANCPGQKPASTQPCNLMPCNTLLQFVTSPFSACNCSGLQTRIVICIQRVGIVLEQVSTQNCLDAGLEALPTTQDCPPPADCVQPNPVWQTTEWSQCPVTCGVGTQTRLVYCIAQPGSTDIVDDSECVAGDKPPTTQECDTEVVCPTAYLWLTYGWGACSVTCGEGFESRDVFCFSLGTNIVQVEDSLCNAGEKPNTVRPCSLAPCTASWTTSGWTECSVTCGPGTQTRTVACQQTKDPNSNVVDESECIAEARPSEARPCYLALCPAPFGCNTSYMLEGTVQYTESSPGFTAGQNYPNDLECSKAFVADNNIQEGRRRRRRNVQEPQYCIQLTFTAFDVEPSTDCTVDYLEISDIRYNTSERLCGNTYELPLVWESVGPHVNLYFHTDATVTRPGYSVIYNAVEKQDPAGYEVTAWSECSVTCGEGVETREVLCVRGNETVDENECSGLQKPVSIQPCVEDECIEPSVCSGDLLRTENNAIILSPDFPSAYPNNISCSNVIRAPEGMIMEIFVTFFNLRPEECSDKVLIKDVNVDGEPLELCGNQAPGIVFTSITNEVTVQFESAETGSISPTGFGFSLRADFMNQPPVSCGNQISESGRAVYSPNYPGDYNLNENCLTVIRNDGGCIKLRFLDIDLPPQNGQCSDFVQLVDLNEIAVNTGPLCGREIPTVFYSFTGLMTVRFFSDENGPTTGGFNAVVNFVDCYDGVWLTGPFEECSATCGEAVRRRTVSCQNPQTDALVDPAMCPPERPDEEIPCDVPECPSCDVTVTESGEIGSPNSPSNYDNNQRCETEIVNPDGCVAINFLAFDLQPGLSDECDTDFLEITDVAREEPIKLCGSTLPDTYQSLSGNVQLLFQTDDSVVSTGYYAYVSFIPCPVNAYIMGNWSECSVTCGAGMRTRDVQCMDLINNVPVEDSVCQGERPPSEEPCMANEECPSCDVTITESLMFVTSPDFPNPYAPNLECVYTFNSPDPDQCVRLTIIEAYLNGADDNELCSRDYLEITSQSGQPPLRFCPESARSIPWYSRDNTASVRFVTDEEGASSGFNMYVVFGSCPMYDFVVGDYTECSARCGGGVRTRVVSCISLSDGSGAPDELCPNQRPLDSIPCNTEPCPVCDAAFFPGDELIMSPDFSSAPGQGYERSLDCTYNITNPDGCLFLTFLSFELQECADCSCDYLSITEDNAEALPPLCGTQNDRTWASTTGNVMLNFVTDNSISAAGFNIYVAYIDCPDVYYFTEDYSECDVSCGGGSQTRLVQCRSRTTGMEVDESMCTGVKPPTERPCGEDPCPFCDEQITTPSFIASPEYPENYPVSINCNYAIQAPAGRCVSINVLAFELQEAEGDPMMCQDYIEIRDQGAPTLDRRYCGLAAPNAIQWRSRFGSVSLDFSSDEEDTSSGFRAYVNFVDCPQYGYVATEFSMCSRPCGGGTQTREVSCQNIATQQPAEEVNCEDERPSESIPCNLQDCPECDEEITENRQSVYSLNFPQPYFEYSCNYIYTNPGGCVELLFVQFEMPIPNAEDVCDKDYLLVEDMSERPFSYRICGPDIPNTVVSRGERLNVTLVTDGNPGTFGEGYQLYNLFTNNCPEVGYVASEFGECDRQCGFGTRTREVNCVDLQSGITVDESLCTDVEPSSTEFCNTQPCPSCDQVVDTFPIALNSPADLDPLRTCQYDIESERCIRATFLTFDFPGENGMCADTFVQLQDEGAEFLTERFCGDGPGAASGAALYAWESRTSDVLMTLNSGTDLTANNRFRIFLTEMDCPEFGFVAGEFDECSRSCGEGGVQTRTVECQRLADNSPVVEGSCTDPKPSETRPCAPQPPCPSCDMFVSDPETLVQGPPRNSNWTTDVRCRITVEYDTSCVVISGLQVMLSEPDENGTCVDSSLTFSDGTYPAYTETVCGSSSGGVYGALSRRYVVDFYSADYENSGDSFNLFVQAAACPVIEYQTSEFSQCSASCGGGVRTRDVTCVRADRMEEVPDDACAGPRPMAIEGCNMEACPKECDNVITVNTPVQLLTSPGRPTYVTDADCTNNIINLSGCIVLAFLSVDIEEGTMPGVCDKDYLEIIDATFDELSVRLCGDTLPSTAWRSQSGSIRTRFVSDSVDTQQAGYTLTYTLTPTCPTGSYVLSGFDDCSATCGEGTRTAADLNCVLPDSSIGTNSDCPGLPPSRVQSCNLGECPEFYFFTGEYSNCSVECGDGTQTRVVECRRLDNDTVVDDGMCTEVKPDTSMACNLMACVDNAFVLSETPQTETVELGDSGTIQSPNFPNAYPNNLNAQVVLTIPANTLLRVTIDTLDLVFESPCANGDFLRFSSGSNTVLQVCQTTQLPFDWFSGAGDTEVTIAMTTSATVAGNGFMGRWTVIVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4E9</accession>
    <name>A0A913Z4E9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 13">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity. Interacts with CHODL. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_038046597.1">
        <property type="nucleotide sequence ID" value="XM_038190669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190669.1">
        <property type="protein sequence ID" value="XP_038046597.1"/>
        <property type="gene ID" value="LOC119720816"/>
    </dbReference>
    <dbReference type="GeneID" id="119720816"/>
    <dbReference type="CTD" id="5876"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000004">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 13" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="332" mass="36948" checksum="8DF5D3061386D965" modified="2023-02-22" version="1">MGTPIKDVTLKPDAPNTLLLDKHVEYIASYGAKKDDYEYVMTEYLRMSGIYWGITVMDLMKHLDSMAQQEIVDFVVSCQHDCGGFGASVNHDAHLLYTLSALQILTIFDSVDTINVDKVIEYVKGLQQDDGSFIGDKWGEVDTRFSFCAVACLALLGRLDAINVQKAVEYVLSCMNFDGGFGCRPGSESHSGQVYCCVGMLAITDSLHHVNADQLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIDRLHWIDKKKLETFILACQDDETGGFADRPGDMVDPFHTLFGIAGLSLLGSFSDRIKPVNPVFCMPEEALQRIRLTTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4U5</accession>
    <name>A0A913Z4U5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038046747.1">
        <property type="nucleotide sequence ID" value="XM_038190819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4U5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190819.1">
        <property type="protein sequence ID" value="XP_038046747.1"/>
        <property type="gene ID" value="LOC119720951"/>
    </dbReference>
    <dbReference type="GeneID" id="119720951"/>
    <dbReference type="OMA" id="AGKRIHW"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016941">
        <property type="term" value="F:natriuretic peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001106">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="539"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="756" mass="86090" checksum="75B4160E0496566A" modified="2023-02-22" version="1">MGATEYQMPAITAKVLVLFLTYVVTRSRVVAVQNEAAPRPSTKRDVTITMAVLLPEWPLMYTDRRYPYFKQMMSPALDIALEKYDRIVPGVSNVSIFHANTDCDVALTMISTVDIRLEFQADVYIGPVCEYATSPTGQFLAHWGTPLLTVGAQALGYDNKYQYKTLTRLQGPFSKMARYIRDYFIYQNWNSTAFLYEDSDTNYRDCHFGAGAAYFALRESGFQTPEAVSFKEEELEDRQNIFRWLQDYIRPLARIVVMCASGDSIRKIMLAAHELGMTNGEYAFFNIFLFDSKYFGDVSWERGDKNDAAAKEAYRSLMTFTLRKPETPQFKAFATQVKERALKQYNFSFDALGEEVNTFVGAFHDAVILYALALNETLEAGENPRDGQALTHRMWNRTFEGIMGNVTIDANGDREADYSLLEMTDIENGVFTVAGYYDGVAKKYTPVPGVVIDWPGPTPPKDVPDCGFKGEFCIEEEDNNPTVMIMMITMAVVVVLAVIIIIYVVRKYRLEMELANMVWKIKWEDITFNNKMDKQRKLTGSRLSLGSGESGQSVWGGNQQIFTVTGYYKGNIIAIKKVNRIRVELTRNVLIDFKHMRDISHDHVTKFIGACIDPPNISVMTEYCPKGSLQDILENDSIELDDMFKYSLLYDIVKGMYYLHNSVIQTHGNLKSSNCVVDNRFVVKITDFGLHSFREPDHPFEPDEDDSFQYYQNLVKSNCLSDSAHLDPQSRTPFCNMMDNMIMSDKNLGNCTIPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z711</accession>
    <name>A0A913Z711_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047489.1">
        <property type="nucleotide sequence ID" value="XM_038191561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z711"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191561.1">
        <property type="protein sequence ID" value="XP_038047489.1"/>
        <property type="gene ID" value="LOC119721481"/>
    </dbReference>
    <dbReference type="GeneID" id="119721481"/>
    <dbReference type="OMA" id="YVDRIAT"/>
    <dbReference type="OrthoDB" id="10004661at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF9">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 middle" evidence="2">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="3">
        <location>
            <begin position="501"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72811" checksum="3C58468C8DA319EE" modified="2023-02-22" version="1">MAVKWNFRCACWGFISSLLASVLLTYCFSPQSHLAFRVIAGAAAVLIGISSLIAFHISTLRCSESHTLITLLMSYKWHQGERLATPSTLARATYMWKRPREAQEDLIRELTRRHAKTEYGRKNRLGEIRSVEDLRKKHPLTTYDHYCDYIQRLADGEEGVFLDEEPMRFGVTSGTTGAGKKIPLVSFGVEGDALCSQIKRLALYQGAQRPSPVQKRCFFYIHPKISLTKTGRVISPYTFIKQENTKRLSELSSPPPAFTITNEPSAVYIHMLFAIADTNLALLSTMFTPQMYRALKCLEAKWQVMLEDLSTGQINAKIPLDPDTRRSLQGYLRPDKARVSQLRSEFEKGFHGILKRIWPHLIAIEAIDIAGFKKKIEETYTDGVPYFNWAYGSTEVGQLAINMWLHDKEARYALCPHMAVVEFIPEQNSSDEDPKTLLIDEVEVGGRYELVLTTRSGLYRYRNGDVIQIVGFHENCPAMRMLYRSGEYLNLVYEKVNTQVVDAAIKNTIQGWPGIQLVDWTCAESPVYDPESSELYYIAFLEVDPGKRELNDVTAEQRSKFDEHLQQDHVYYSGLRESNTISPSRVKFVRPGTFLELRDFRVNKTTASVMMYKTPRKLRTREHVIWMMERVIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAG0</accession>
    <name>A0A913ZAG0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038048753.1">
        <property type="nucleotide sequence ID" value="XM_038192825.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192825.1">
        <property type="protein sequence ID" value="XP_038048753.1"/>
        <property type="gene ID" value="LOC119722626"/>
    </dbReference>
    <dbReference type="GeneID" id="119722626"/>
    <dbReference type="OMA" id="QICFALC"/>
    <dbReference type="OrthoDB" id="10069150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="646" mass="72859" checksum="719397936C75466C" modified="2023-02-22" version="1">MTEKDRNQAVNEVAILASLKHANVVRYREAFMERDTLHIAMEYADGGDLNEIIKSNRRDGQHITENCIMDWFVQICFALCYIHAKKILHRDLKPQNIFMTNEGIIKVGDFGIAQMLRGTREHAHTAIGTPYYMSPEICRRKPYNHKSDMWAAGCVLYEMTALVHPFEANDISSLVIKITRGNYKAIPRHYGPLLDDLVSVLLRVEPERRPSADQILSIPGIQNYVLAFTDQCKNQCSSPGIMREWSQSSNHKDENVFRNEQTSAVTARRHSFTSIATEQIFCAQSTYSKERHQSVRDRMGECELAQRGTVLKVQSGNKETARVIAGGQFRHVHXTGWQHRVISTVYRTPNKVKPLTEYQDCTKGSTDRTAFQQSSLLAYGVNGTDTEISDGEITSVDAENSSNTLRKDFVQGKIEICQNKKANLNDDLQLKMPITNLFDFECNGDNSVTIGSLKESTYVLDKPSVICVSNKESNKRRPSVITKVVQIPERCDGNRRNIFHPRSSNSDLEGTKTKHESREDKFSCARGNCNCDLRECSANAQHNGGVLADLNECLFRSRISTGDSAREVRGKIETFRAYLEEKIGVELSFACLNAIRSVSGGKMHRFVSDDIALKRMGGILGKDKMQFAPAVLYLHNLEQSCDLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCH1</accession>
    <name>A0A913ZCH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048740.1">
        <property type="nucleotide sequence ID" value="XM_038192812.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048741.1">
        <property type="nucleotide sequence ID" value="XM_038192813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192812.1">
        <property type="protein sequence ID" value="XP_038048740.1"/>
        <property type="gene ID" value="LOC119722611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192813.1">
        <property type="protein sequence ID" value="XP_038048741.1"/>
        <property type="gene ID" value="LOC119722611"/>
    </dbReference>
    <dbReference type="GeneID" id="119722611"/>
    <dbReference type="OMA" id="PIINSHP"/>
    <dbReference type="OrthoDB" id="5980560at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="58"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="27213" checksum="64856F96EAB31256" modified="2023-02-22" version="1">MASSDRNAEHLPLTPRAVENHTEEAQASSDSLYENDNYHSLSPEQEAHYHRAVLFLAWFSVFALLVLSITSFVISQSSSSVALFGFGLDALLDVGTSLVVVWRFYGSSQTVYSRERERIALLVLAVLFIAASLLVGIRSLVFVIKGSTVEEILALYIVSTIAVVISLMLFLGKMHVGYKLRSKTVISDGYSSLACGIGSLGVIISACIHSKNSNIYYLDDVVGFTMAALLLGYGISLLMSNWQKKESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDQ7</accession>
    <name>A0A913ZDQ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049912.1">
        <property type="nucleotide sequence ID" value="XM_038193984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193984.1">
        <property type="protein sequence ID" value="XP_038049912.1"/>
        <property type="gene ID" value="LOC119723376"/>
    </dbReference>
    <dbReference type="GeneID" id="119723376"/>
    <dbReference type="OMA" id="MFNFGWS"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37190" checksum="96D7A1ACE166E1EA" modified="2023-02-22" version="1">MAEPLLILRIIKTLVGLLGLIGNTVVATVIYKVEFMHTLTNAFICNQAVVDFLGSLFLILSSNIAAPDPLPDTLGYHVACHIWLSNLLMWACFTSSSVNLLSLTCERYVAIVYPFRYARLYTNKTVVLMLVIIWLSGLILDGAYTAAVNTFEDGKCFYSSAISSRALGIVFIMFKFFIPAIFMVFVYSHMTVELKRSATRIGNIAPTVSATVHSGASTAASSVEAPEQSLLRARRNVFKTLVMVFATFLVCWTPNQVIFFMFNFGWSLDFSGAIYIISVSLVAINSCVNPFIYAFKYKQFRRGFQSLIGRGGQAEGDSLQTSEAATRQWNPRNGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFL6</accession>
    <name>A0A913ZFL6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049765.1">
        <property type="nucleotide sequence ID" value="XM_038193837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193837.1">
        <property type="protein sequence ID" value="XP_038049765.1"/>
        <property type="gene ID" value="LOC119723274"/>
    </dbReference>
    <dbReference type="GeneID" id="119723274"/>
    <dbReference type="OMA" id="SDNCEAF"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137">
        <property type="entry name" value="OS05G0310600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137:SF3">
        <property type="entry name" value="OS05G0310600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="96"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="284"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75930" checksum="CB3B6E23374C1DC0" modified="2023-02-22" version="1">MAKQASDEFDDEMLENVANSLDQAWPTVATYLSFDDGDCQAIIEAHPGHINQQALQMLTAWRAGYAGADILAELKGALREVGLHTLLHELGEEILETPTLQKVAKSVDEEWPQLALYLSFDVEQCQHIQAAFPTTKEQAGQMIAAWRQSFTGDNPVEYLATALIAIGRDDLARELAPHQKHPKCHCDNNKPLKYRPYYSKGEDGGSRLLGICCTNCGQEWLEGRFLFHPDEDNTRPSVKLRGVLLKKQLEVPTESNPAFQVKGSRTKIENFKFVCDYLKVGDHITWRRHWGYWHHAIVSEIDGVGGRVKVIQWCKSGCGVIKIIEKWLELSQEEGELYRIDYEKKITEVNTPELVIARARSRLDDTGYGVFSDNCEAFASYCKTGLAESWQVVWLYQKIKSVVKGALASVFGKAGFIVAREYAKDGAKAFLEQGTEAAAKKVVVAETFERLSHGTNAVGAGIILVFDGCACVYDLDQIYKNRNRGDLSRQDFISSAFSRVSEAVLGAGLAVGGGIAGESVGFSAGAAAGTFIMPGLGTAVGAFIGSIVGGVIGSTLGRYIGVSVGSPIGRALAITIGTNDRAVKNIRDLNPGDQVVFFGNLLHPRHHAIVVDCDPLKGKVRVVHNTYQNGVVEELVDFSQPVYRLEYDKECYPPDEVIKRARSKIGDETYKYSLAFNNCKSFGRWCKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFM2</accession>
    <name>A0A913ZFM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anosmin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049846.1">
        <property type="nucleotide sequence ID" value="XM_038193918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193918.1">
        <property type="protein sequence ID" value="XP_038049846.1"/>
        <property type="gene ID" value="LOC119723343"/>
    </dbReference>
    <dbReference type="GeneID" id="119723343"/>
    <dbReference type="CTD" id="3730"/>
    <dbReference type="OMA" id="RPHLKHH"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.75.10:FF:000001">
        <property type="entry name" value="Anosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036849877" description="Anosmin-1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="266"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="542"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79567" checksum="A1FCC15BCE46C71D" modified="2023-02-22" version="1">MGEMTKLKGVALLGVLLGSIGTSYGNILEAQCRARCYTTLHISRGESYRISCSNSTNCSSCVIPCSTEYKTLSLCKAKCQTATELSWCHNTCEFLKLSHSQKPGSCPTPEDITGFGKACAETCSNDSQCNGQEKCCYNGCGHTCQTPVIDKSELPPKPRNSPTITEDANGQSVTIHWELRGNSPDLEGVVLYVIQGRNNTGHHPSTSRMGDWKDLSITDQMEYVTELNVGTYYRIQVAAVNENGSLGFCKPTLPFRLSRSPEAPSAPLNLREGEATGVDNRINLRILWDPPKTSDLQITRYRVFYSIRPSRALPFHVRIEEKSHNVPGDQYDITLEELHPNMRYYIQVQAIAQWGDARKRSDRTSLTIQTMDLPIVQDDAPPMYEPVPPEPPVHGEPPVFPGPVRDVVPDGPYWEDSSLKCQISWRKPKGFEKTVNRFTIHWQPMGCANDYINSSLMTATTHANEIFPRYPAMGATTHDRSFEIYNLKFDCQYRVSVVAVSDSLLTSPEANIRFYTPACNNVRVKDQQKPTCPTPLPDIPSQPENVTYMFMLSHSNITAHFMWDPPRFSLYPVIGYRVMWAEHRTIEDRLFGEGFPLLAKVEHLILPATKSWHAIAHLKSGTPYRVQIQALTNVSGGALAIEDIKTPKIQNNPQPSSPTAPASVRPTDGETSTHNPTNPTGIGAGHSGTTSWHAASRISRALTLTVCCLLYLAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG13</accession>
    <name>A0A913ZG13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050737.1">
        <property type="nucleotide sequence ID" value="XM_038194809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194809.1">
        <property type="protein sequence ID" value="XP_038050737.1"/>
        <property type="gene ID" value="LOC119723907"/>
    </dbReference>
    <dbReference type="GeneID" id="119723907"/>
    <dbReference type="OMA" id="LECHIAY"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="20910" checksum="196A5836D21E9B10" modified="2023-02-22" version="1">MRKSFRFSLSCAIQLLYCCGFVAFPMFLIPRAQTIGVAPSSAASLMSILGIGSLIGSLGNAPMIGWRISAEHVTAICAGLTGIACLLVTADGYAYLAVASFIYGFVSGAFFAISIVLCRSFVGVQHFALGVGLMNVFIGTGYLIGPVIAGWIFDATRSYVAVFYMLTGVHFTCALKCLLLPLLKRIEPGLDPKVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGA0</accession>
    <name>A0A913ZGA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050822.1">
        <property type="nucleotide sequence ID" value="XM_038194894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194894.1">
        <property type="protein sequence ID" value="XP_038050822.1"/>
        <property type="gene ID" value="LOC119723971"/>
    </dbReference>
    <dbReference type="GeneID" id="119723971"/>
    <dbReference type="OMA" id="ICAMWES"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="34747" checksum="3BFC9A17E812A578" modified="2023-02-22" version="1">MAEQATRAFQSVVGIVGICGNGLVCAVIAKVRFMHTLTNTFIFNQALIDLLGSLVTLLLNIVPIPDPIPPGATGVFICAMWESGYLQWGLFTASTFNLVVLTLERYLAIVFPFKYQALTYHKRAIAVIFAGIWVCGFLFNGFGIYLRYYEAGECVLNPVAHPEALGVFIFACRFLVPFFVMLVVYVHIAVVLKKGAGRVLPAPAAAGPSTGQAPEGQGESLMRARRNTFKTLMIVSTIFVICWAPSEVNFFLFNLGVEVDFNSPIFYIMIGLGALNCCLNPFIYAIKYKQFQKALKVVFCKRGDEASLSTVSTSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHH4</accession>
    <name>A0A913ZHH4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051238.1">
        <property type="nucleotide sequence ID" value="XM_038195310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHH4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195310.1">
        <property type="protein sequence ID" value="XP_038051238.1"/>
        <property type="gene ID" value="LOC119724316"/>
    </dbReference>
    <dbReference type="GeneID" id="119724316"/>
    <dbReference type="OMA" id="PKHMARW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036676566" description="Alpha/beta hydrolase fold-3 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="105"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="314"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="406" mass="45751" checksum="7BF978F80D6C232B" modified="2023-02-22" version="1">MARLIVAVIVVVAAVAAYVVLEPVPDDVGERPWAVKMESFRRTWKRHLKWWTPTGLNQWLEEKSAAASRAAGPRVPYGEAVFDRVPVRIFADEPAGAKKAKRPAIVYYHGGGFIRGSVDNHHPVTALLARDLNAVVVSVDYLLSPKYPFPAAIDDCTAATVWFLNHLRDFNVDPARIALMGDSAGGNLAAAVSQRFTFDPKYRDLPKIKLQALLYPCLQAFDFQTPSYQQYGDFKTLLLDRPLMTFMWDSYLRGNKASYREAMRINNHTSAAAKRSPLVKKCLSHDLIPDEFKQTGYEAPATNFGDKSIYNEIKEVLLDPDYAPLMREDLRGLPEAYIITVKYDILRDDGIMYAKRLEKAGVPVTWKHYKKGFHGMFTSEEDLPTVTTPPGTQCVSDFLKFARKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI46</accession>
    <name>A0A913ZI46_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051059.1">
        <property type="nucleotide sequence ID" value="XM_038195131.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195131.1">
        <property type="protein sequence ID" value="XP_038051059.1"/>
        <property type="gene ID" value="LOC119724193"/>
    </dbReference>
    <dbReference type="GeneID" id="119724193"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000537">
        <property type="entry name" value="Notch 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2311"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="724"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="880"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1348"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1660"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1816"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1970"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2008"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2046"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2246"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1374"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1686"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1842"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1996"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="2034"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="2276"/>
            <end position="2285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2410" mass="246901" checksum="0A0EDA145ACFDEE6" modified="2023-02-22" version="1">MQANQPTTDGPTTQANQPTTEGPTTQANQPTTDGPTTQANQPTTEGPTTQANQPTTDGPTTQANQPTTEGPTTQANQPTTDGPTTQANQPTTEGPTTQANQPTTDGPTTQANQPTTDLEGPTTQGPMSATTMQSSTPGLRSVTIVLSIVGVNNTALNSSDYTDPNSAASMELAELVARVIASVLGENATTSDVESVSGAISFGPDGVVFTGDVFVPVDSPVTPETIMEVLSNQAAAAPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCADGINSYVCTCVEGFTGNDCETGLRSVTIVLNVRGVNGTALISSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVSGAISIGPDGVVFTGDVFVPVDSPVTADTIMEVLSNQAAPGPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCAEGFTGSDCEIGLRSVTIVLNVRGVNGTALVSSDFADPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAVAAPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCVDGVNSYVCTCVEGFTGSDCEIGLRSVTIVLNVRGVNGTALISSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLNVDPAVTARDEDNCDPNPCMNGGSCTDGVNSYVCTCVEGFTGNDCEIGLRSVTIVLNVRGVNGTALVSSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDVVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCVEGFTGNDCEIGLRSVTIVLNVRGVNGTALVSSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGIFIGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCAEGFTGNDCEIGLRSVTIVLNVREVNGTVLISSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLNVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCVEGFTGNDCEIGLRSVTIVLNVRGVNGTALVFSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVSGAISIGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAGPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCADGVNSYVCTCVEGFTGSDCEIGLRSVTIVLNVRGVNGTALISSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLNVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCVEGFTGNDCEIGLRSVTIVLNVRGVNGTALVFSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVSGAISIGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAGPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCADGVNSYVCTCVEGFTGSDCEIGLRSVTIVLNVRGVNGTALISSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVFVPVDSPVTAETIMEVLSNQAAAAPLTDGQSTLDVDPAVTAMDEDNCDPNPCMNGGSCTDGVNSYVCTCAEGFTGSDCEIGLRSVTIVLNVRGVNGTALVSSDFTDPNSAASMELAELVARVIASVLGENATTSDVESVIGGISVGPDGVVFTGDVLVPVDSPVTAETIMEVLSNQAAAAPLTDGQSILDVDPAVTARDNCDPNPCMNGGSCEDGTNSYVCTCVEGFTGNDCEIDIDDCDPDPCMNGGACQNGVNSYTCTCVEGFTGSDCETDIDDCNPNPCLSGETCEDGINRFTCTCIQRNCQTDPCVLNPGRCAATPGQYCLPVPFSELPARHRCACRELDGYFWDSSANRCSQNGFRAVMIEMNVEGINGTALGLDDINTPGLLAVVAKVIQSELGLMPATSDINQVHPVQLVVRDGRVMFMGVVQVPAESTITARVIESMLSTLASSRALTDGQTTLNVDPQVTAMVSTTACPPNFCQNGGTCDVSGNYPALDYTCRCATAFTGSNCESVIPVPTEKPVTFAPTMAPGDSMSLLTAVLILLAVIALLLVLSCLCCFLALRLRRRRRRYPVYERRVMYAYFNPVAGRTMKRPEFVTPYVASGQEARNYYDQRAFEGRYPVAGRVVKNPILAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIQ7</accession>
    <name>A0A913ZIQ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050930.1">
        <property type="nucleotide sequence ID" value="XM_038195002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195002.1">
        <property type="protein sequence ID" value="XP_038050930.1"/>
        <property type="gene ID" value="LOC119724096"/>
    </dbReference>
    <dbReference type="GeneID" id="119724096"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="265" mass="30386" checksum="03D11EC103FA6067" modified="2023-02-22" version="1">MEVVNLILVDGHEDKINRAQQSYPVEFHIQRPNAPPPQYKTMTEWKAPRVIMTHLTEELMPSQIYQGKGKVVYVIRNPKDTTVSNWKFIGPMNFDPKYEKWDDFVRESFSEDMVFGSWFTHVLNFWKKHRHDKNFLFLKYEDMKRDLKGAAIQISDFLGKNLSDEAIERVVEFSSLKSMKARFNQAKEAKDTKEEAPQSTPADKASAPSGDGAKAATSRKIGAPSIIRKGIVGDWKTMFTVAQNEQVDALYREKMAGSGLTIQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIT3</accession>
    <name>A0A913ZIT3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038051279.1">
        <property type="nucleotide sequence ID" value="XM_038195351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051280.1">
        <property type="nucleotide sequence ID" value="XM_038195352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIT3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195351.1">
        <property type="protein sequence ID" value="XP_038051279.1"/>
        <property type="gene ID" value="LOC119724343"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195352.1">
        <property type="protein sequence ID" value="XP_038051280.1"/>
        <property type="gene ID" value="LOC119724343"/>
    </dbReference>
    <dbReference type="GeneID" id="119724343"/>
    <dbReference type="OMA" id="DYCNANC"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034329">
        <property type="term" value="P:cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06647">
        <property type="entry name" value="STKc_PAK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="260"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="59478" checksum="55F9CB3DC6477E06" modified="2023-02-22" version="1">MSDNMEESPPAPPVRYTSTGGTLKSDASSPGSKPLPSTPTDDEKKKRKIKMPWQGKNEDKSSKQRPEISYPTSFEHTVHVGFDSITGEFTGMPEHWAKLLMSSQITKTEQKKNPQAVLDALKFYDDSNANRNEKFMTQQKVILSSNNKGSLEDTFEQTSLNAKHGQKSVDVEEDEDDDNGPAPAIAPRPEHTKSKYYSRIEPPAEPAPTPVSPPPPAAINNAEGSVQRTRERQKKKKMSDDEILDKLRQIVSVGDPKKKYTKCEKIGQGASGVVYTAIEVGTGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGGELWVVMEFLAGGSLTDVVTETCMDEGQIASVCRECLQALEFLHRNHVIHRDIKSDNILLGMDGGVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPEIQNPEKLSPVFKDFLAQCLETDVDKRVGSSELLVHPFLKMAKPLKTLVPLIMAAKEASQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJE1</accession>
    <name>A0A913ZJE1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051180.1">
        <property type="nucleotide sequence ID" value="XM_038195252.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195252.1">
        <property type="protein sequence ID" value="XP_038051180.1"/>
        <property type="gene ID" value="LOC119724274"/>
    </dbReference>
    <dbReference type="GeneID" id="119724274"/>
    <dbReference type="OMA" id="STILKGW"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="483"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1348" mass="152920" checksum="B3BB51DD481132D3" modified="2023-02-22" version="1">MDVLPPPSALELTGNVAENWKRFKQRFQLYIDAIGASKKDDRQQTSILLHVIGEQALDVYNTFKWDEEGDQEGDNMRLVKVMAKLEKYCTPKTNLTLERFHFNNCCQQPGEGIDAYLTRLKKHSKKCEFGTLQDSLVKDRLVCGIVANVTRERLLREEDLTLEKAVKICKAAELVKERSKELQSTTPTVHAVQKNPSAKPKPQGANRKPQATAKPQNAPKGKPSRWKPRNDQQQQTSDKHHCRRCDNWHVSGKCPAYGETCAYCRGKNHFAKCCFKKRAQGQVHTVDNDESTDFFLDTITVDSVKTQANDWIFPLAMNGTIIPVKLDTGAQVNILTETDFSRLKNKPQLHPATETLKAYNHSQIIVKGKCVVTVDHAARKHKMLFFVVPGDKQALLGRQACEQLGLVKVACAVTNQEQPKDPNDNYANLLHEYGDIFEGLGCLPGMHTIIIDETAQPVVHACRKVPFALHNGLKRELERMESLGVITRVDEPTDWVNSLVVVKKKNGDIRVCMDPRDLNRAIKREHYKMPTREEVMSQFAGASYYSKLDASQGFWQLQLDDKSSRLCTFNTPFGRFRYTRLPFGISSAPEVYHKTVHQIFESIDGVSTFADDIIIYGATKEAHDRSLRLTLETARQVNLKLNRSKCEIGVTQLTFIGDLVTTDGVKPDPNKVAAINNMPKPENKQELQRFLGMVTYLAKWIAGLSQKSAPLRALLKDDNEWQWGPEQERAWSDLKATVSTDPVLQYYDSNCPIRLSSDASKDGLGAVILQLHDDKWSPVAYASRAMTSAETRYAQIEKELLGIVFACERFHQFIYGATVEAETDHKPLISLFKKPLNDCPLRVQRLLLRVQRYDLHVVYTPGKQLVVADALSRAPDRNADQGEAAQVQSLDDVVEAFVDMIIETMPVSDNRMKQIREATQADDQLTNLKQVILQGWPEASQQCPSDIRPFWNIRAELTVAEDVIFKGTRIVIPRVLRKDVLLKVHEGHMGIEKCRRRARDVVYWPGMNAEISDMVSQCDACQKHQPSQSVEPLNPHEIPVRAWQRVGADIGTVKGKEYLIVCDYYSGYPEVVTLTTTTSKAVINAMKSMFARHGVPDVVISDNGPQFGSREFADFTKDWGFEHHTSSPHYPRSNGLAESAVKTVKQMIKKCQETKQDFHKALLAYRSTPLQNGLSPSQMLMNRRVKTTLPVHPQRLEPEVQQGVVSDKILRRNQQKQVHDRNAHPLKPLHTQDRVRVQDHRTGLWTVRATVLRKLAPRSYEIKTDVGWILRRNRGAIRKDTVPDQTSIDPELLEEELALQLATEHLVGTEAQEPAKQDHATPVRSLREQTLRRSTRTIRRPERLIETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK33</accession>
    <name>A0A913ZK33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052177.1">
        <property type="nucleotide sequence ID" value="XM_038196249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196249.1">
        <property type="protein sequence ID" value="XP_038052177.1"/>
        <property type="gene ID" value="LOC119724929"/>
    </dbReference>
    <dbReference type="GeneID" id="119724929"/>
    <dbReference type="OMA" id="CKKIDQG"/>
    <dbReference type="OrthoDB" id="5984119at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="130" mass="14823" checksum="7819622AAED61A72" modified="2023-02-22" version="1">MTKPVGRQNDEDSSEDDGAKKPKTSTTSGKIRKVGGKRGRKPSKIDQKAKLERSRQSARDCRARKKQKYQLLEEMVAGKERDICALREELDMYKQWCKKIDQGTIPPEIYDTLQTGEVAKPNDPIKEEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLY1</accession>
    <name>A0A913ZLY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination factor 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052068.1">
        <property type="nucleotide sequence ID" value="XM_038196140.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052069.1">
        <property type="nucleotide sequence ID" value="XM_038196141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052071.1">
        <property type="nucleotide sequence ID" value="XM_038196143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196140.1">
        <property type="protein sequence ID" value="XP_038052068.1"/>
        <property type="gene ID" value="LOC119724862"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196141.1">
        <property type="protein sequence ID" value="XP_038052069.1"/>
        <property type="gene ID" value="LOC119724862"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196143.1">
        <property type="protein sequence ID" value="XP_038052071.1"/>
        <property type="gene ID" value="LOC119724862"/>
    </dbReference>
    <dbReference type="GeneID" id="119724862"/>
    <dbReference type="CTD" id="51001"/>
    <dbReference type="OMA" id="NSIARCP"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000002">
        <property type="entry name" value="transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="521" mass="59366" checksum="992487C6B2368456" modified="2023-02-22" version="1">MATKMLLRSGTCNQLLEVLNGPARSVPALTNCSTCPRFSFEPTSKPITTKGRVESSSRRQITSVSLASGATGTEHVASLRFHKAPPSFHLCKRLLSDSKTEDGNGKACSSSEDTEKTDSRSLQESEQEQESDDLDILDKDTKELSESSIKITERDLFNSESSESKHVERTETGSENSLQHVHSKTRDDVENVEEVKDETSVSLIIRTKPEHELDFIDDQEAVDILAPRETPTVLEEFIQPYLPTESLTLATYVDHSPTLQKLVELGVDLSKVEKKAKIGNMLIKMDFDRHMKDKIILLHSVGMTSATGLGRFLTINPFFLTEDLENLKTRLRYLRSKKFSEDAITQVLNRAPYFLSFSVERVDSKLGFYQKELSLTGNELRNIITKTPKLVTFKIQRVKENIFVCRQQLGFTTFELKNLILKEPKLLLRGKEKLIGMFDYLHNHMGIPHKQILKNPTVFNGRVFRMQERHQFLRFHGRAQYDPTQPGYVALERLAKLPDDVFCQEIAKSSKEEYDNFLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM56</accession>
    <name>A0A913ZM56_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052837.1">
        <property type="nucleotide sequence ID" value="XM_038196909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196909.1">
        <property type="protein sequence ID" value="XP_038052837.1"/>
        <property type="gene ID" value="LOC119725503"/>
    </dbReference>
    <dbReference type="GeneID" id="119725503"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="253"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="992" mass="109845" checksum="B7940B7B8571DDAF" modified="2023-02-22" version="1">MKTTTRRGRKVEIQYIDMVKHDSGSRFTKRRSQDGSDDEGVLSGLKQLFRDYMMSEPDVARVSNESEAYVLIEEKTAEGEEEGERMQTEEPMVEEEIAATKVTSEEFSLPPTETDSTVNGEVAEEKQERKRITKSISLTQEDMDSNKAKRAISGRLTQFQKACQKENDPGQATQRGGSKRLDLSKYQPMGGDQGNKRASMTKRLDTSRFSKFEGDSTDSGAATPVKVTRNFTISPASRKFNAEKQPTITTPNNRCKICQKTVYPMEKITADGFNYHKLCFRCTECNTLLSLGNFAQSKQFLYCKHHFKQLFKLKGNYDDAFDGSSRSSRKAGVADSENGIDESDVQQTSEKEASSFEGAKSLKDQFEKGAVSNVAVKKSFDRDAITRTREDLDQTTPEDKQVSESEPVLRPDVVRSADSVDDRVAIAGMRSLRDQFERGDSSLSSSGKSFDFQGEIRAAKEAEVQATVGQVAESTPVRSEDVIRSDVKADEVKTSSGGIRSLKDRFEKGAVSNIETTPVKPVIEVRPLEDYNPGDSESGVSENTPVVRDDVVRSSEKVDDGFFKAGGARSLKERFEQGKVSNIEGKPKEKIEISPRSLEEYGADQDSIDQGGVSENTPAQRDDVVREGKGEENPGIKRGAARNLRSLFEKGEVHNIEEKPRAPLERSPKSLDQLAPSTEGVVENTPEVRADLARETTVRDEPMNIQTGVSRSLKDRWEKGEVETAPMKPKEVVDIKAELRGQGQVAESEPAVREDLVRESSEIPEETSAGASSLRAQWEAGEVTHAENRLQKEELSPKRLSSYYDGDQEEVEVAANDKMEEVVEEEQLVQAEEEQAVEQQVEAEEEQSAEPEADQEVEAESEQEVEAKGEPLVELDVEQEVGVQEEQLLQFDAEPEKQDVEEDEAVNGQPEEENQQVINGHTEENGLESEVASPQLDGEEPTTDFPEQTAPGQDMASWEIKAARAAALQDAEEAADEGTPVDGANTGLLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM75</accession>
    <name>A0A913ZM75_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ITM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052903.1">
        <property type="nucleotide sequence ID" value="XM_038196975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196975.1">
        <property type="protein sequence ID" value="XP_038052903.1"/>
        <property type="gene ID" value="LOC119725543"/>
    </dbReference>
    <dbReference type="GeneID" id="119725543"/>
    <dbReference type="OMA" id="PEQDYCE"/>
    <dbReference type="OrthoDB" id="10069478at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="11">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36743" checksum="3048E40730862C1F" modified="2023-02-22" version="1">MVKPSILPEGGKKEASKEAKGTEASLPAFAVIPLGTDLPPKYDDCTVEAAPIPVVNRPRKLGVCLCVSMLLTLLLIIGLAVVMFLGHASGKYQFRCGVGYGDYKDYPSSHEDRGTLEEEVEVDPFEGYEQIEIPEQDYCERLTILHDFTVNMTAYRLRRSQVCYVTFLDKEIVMGPDEFIERAEENPQFLTDHYETVHETYRVVLPELTPTSLNSGRFGFYIPMLCDGVESYWIEKIPEDELEAWEAYWASQDQEDSESREDGHDQDDDDDFELPNPEHRRRRAVGGASDVKEFLAFEGHKLSKFKIYTKEAVEAFKKASNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNG7</accession>
    <name>A0A913ZNG7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cleavage and polyadenylation-specific factor 3-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052919.1">
        <property type="nucleotide sequence ID" value="XM_038196991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196991.1">
        <property type="protein sequence ID" value="XP_038052919.1"/>
        <property type="gene ID" value="LOC119725552"/>
    </dbReference>
    <dbReference type="GeneID" id="119725552"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000003">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="245"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="596" mass="66959" checksum="5993EBA48EBFACC0" modified="2023-02-22" version="1">MAEIKVTPLGAGQDVGRSCILVTIGGKNIMLDCGMHMGFNDDRRFPDFSYITRTGRLTEHLDCVIISHFHLDHCGALPYMSEIVGYDGPIYMTQPTKAICPILLEDYRKITVERKGETNFFTSAMIKDCMKKVIIVNLHQTVQVDDELEITAYYAGHVLGAAMFRMKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDILITESTYATTIRDSKRCRERDFLQKIHDCIEKGGKVLIPVFALGRAQELCILVETFWDRMNLTVPVYFSLGLTEKANHYYKLFIMWTNQKIRKTFVKRNLFDFKHIKPFDRGYIHNPGPMVVFATPGMLHAGLSLQIFRNWASNPLNMVIMPGYCVAGTVGNKILSGAKKIEMENRQVIDVKLSVQYMSFSAHADAKGIMQLIRMCEPKNVILVHGEAKKMEFLKQKITGEFGIQCHMPANGEVVAMETKANLTADVSLSLLKRSIALSGDALKDVKKPRVLHGAVTISGEKMHLEDASKTMQQLGMTEHEIRFTSTVTIPSMSMEVVQKKLKRRFPHQSVQLTSDGSILVGSVLVKVAGESEESLDLLVSWPYQEEDLGSSLFTILQHGFASHTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNZ7</accession>
    <name>A0A913ZNZ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053513.1">
        <property type="nucleotide sequence ID" value="XM_038197585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197585.1">
        <property type="protein sequence ID" value="XP_038053513.1"/>
        <property type="gene ID" value="LOC119725957"/>
    </dbReference>
    <dbReference type="GeneID" id="119725957"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="20052" checksum="ADC51316D6FBEE30" modified="2023-02-22" version="1">MSQKTVQQLDSYIKATAVVYDHSNTKLISRKTKVKPRRKQAFLSVLHYRKTSADDCCAKSRRSKQRVPRQLGCTNESRSHVMKQKLQIFVQTPVLHTPKTLCFRLDPETSISTLKDWIQQTIGVEARYQRLYIRRNFQLCDLLTLEDNGIEKDENISLRLSFDGLLGGGPKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQP2</accession>
    <name>A0A913ZQP2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053699.1">
        <property type="nucleotide sequence ID" value="XM_038197771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197771.1">
        <property type="protein sequence ID" value="XP_038053699.1"/>
        <property type="gene ID" value="LOC119726160"/>
    </dbReference>
    <dbReference type="GeneID" id="119726160"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19232" checksum="FF4DF44750F025F1" modified="2023-02-22" version="1">MFFHVQADWSIAEMNAEIGESHAHLYTSQTDEQTKHTNTHARTVHARTVLNNRLRTLIHSLVVLTRPGKWTDDCSDCRYRCLVLLIIVIILITLVIRKVKGKRTRSQSSYQMTIPPPHPPNQCSQDRPGNASDENCFTAVGGATVESTISTSAGFDLSGGPLAKCQLNCRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRP4</accession>
    <name>A0A913ZRP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 H</fullName>
            <ecNumber evidence="8">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038054317.1">
        <property type="nucleotide sequence ID" value="XM_038198389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198389.1">
        <property type="protein sequence ID" value="XP_038054317.1"/>
        <property type="gene ID" value="LOC119726634"/>
    </dbReference>
    <dbReference type="GeneID" id="119726634"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="181" mass="20589" checksum="843D8D0B215BB72E" modified="2023-02-22" version="1">MSSPPPNKRRMDTDVVKLIESKHEVTILKGINELMVKFHGPKGTPYDGGVWKVRVDVPDKYPYKSPSIGFLNKIYHPNIDEASGTVCLDVINQTWTPLFDLSNIFESFLPQLLAYPNPNDPLNGDAAAMYLHKPEEYKKKIREFVQKYATEEALREQDAQSSSSESSMSDFSEDETQDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS91</accession>
    <name>A0A913ZS91_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053956.1">
        <property type="nucleotide sequence ID" value="XM_038198028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198028.1">
        <property type="protein sequence ID" value="XP_038053956.1"/>
        <property type="gene ID" value="LOC119726373"/>
    </dbReference>
    <dbReference type="GeneID" id="119726373"/>
    <dbReference type="OMA" id="RGSFNMA"/>
    <dbReference type="OrthoDB" id="2575524at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="346" mass="35327" checksum="0F556087843B7CD7" modified="2023-02-22" version="1">MQTTQGPGQATDAPVKPTEAPLESTDAAVESTTAPVESTDTRIEPTDAPVDPTAAPVEATDAPVKPTNAPVKPTDAAVEPTDAPVEPSEAPVEATDAPVQQTDARVKPTEAPVEPTDAAVEPTAAPVEPTDAPVQPTDKAVEPTDAPVQPTEAPVEPTDAPVEPTAAPVEPTDAPVQRTDKAVQPTDTPIEPTDAPIEPTDAPVEPTEAPVEATDSPVKPTDAPVKPTDAPVEPTDAAVEPTSAPVEPTDAPVELTVIPGKTDGKTVDTMQTTQGPVQATDAPVKPTEVPLEPTDAPVESTTAPVESTDTRIEPTDAPVDPTAAPVEATDAPVKPTNAPFSKLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUF0</accession>
    <name>A0A913ZUF0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055202.1">
        <property type="nucleotide sequence ID" value="XM_038199274.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055208.1">
        <property type="nucleotide sequence ID" value="XM_038199280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199274.1">
        <property type="protein sequence ID" value="XP_038055202.1"/>
        <property type="gene ID" value="LOC119727405"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199280.1">
        <property type="protein sequence ID" value="XP_038055208.1"/>
        <property type="gene ID" value="LOC119727405"/>
    </dbReference>
    <dbReference type="GeneID" id="119727405"/>
    <dbReference type="OMA" id="TIACKIC"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07165">
        <property type="entry name" value="NR_DBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="167"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="518" mass="58108" checksum="0907C989E2B24DAE" modified="2023-02-22" version="1">MEVGEIDDVSQLPVQVDVSSPTSFQSNDTDGMAKSPLGPHRTGSGNRIDFPTIACKVCGDRSSGVHYGIISCEGCKGFFRRCLRRQKEYVCVRGGKCEVSRNQRNRCPACRYTKCTELGMSKDAVRIGRIPNKQKETEFADIQPFTIEALQEHDADQSTPLIEADPETTQLIENVVKAHSETAKNYTEFDDFLKGNLELPCRVHDCKDLKSDLELNSMNGLTMWCSVVTQMLSLFIKRIVTFCKYIPGFAVLDQQDQMVLIKGGFFEILTVQDSIELVLYDAFMLNKDLLITRPNMLKFMPPELVESLYDFSQRLHRLRLTLTELALLSAIVLYADDRENLIDRKAIAAMQAKLLMALKVEVQRNHRSDPHMFAKILLRLPELRTVDNLHTQFIMKLQLGVGRGDLPIPALYKEVYDLGMAGLQAKESPAEDVDDDDEKSLDGESDSIPSIKKEIEEDSSPAEGVEGLEQGAELVKEEANETKLDKHQKDLEQIALVGPDGMARLARSKVNKVDAGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVG7</accession>
    <name>A0A913ZVG7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic FMR1-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CYFIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055265.1">
        <property type="nucleotide sequence ID" value="XM_038199337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199337.1">
        <property type="protein sequence ID" value="XP_038055265.1"/>
        <property type="gene ID" value="LOC119727455"/>
    </dbReference>
    <dbReference type="GeneID" id="119727455"/>
    <dbReference type="OMA" id="DQPNRVE"/>
    <dbReference type="OrthoDB" id="10265867at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="4">
        <location>
            <begin position="82"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1275" mass="146602" checksum="03959AD19DF5194B" modified="2023-02-22" version="1">MEVDTEQEPQGASKPQLQPGKMAATVTLEDALSNVDLLEELPLPDQQPCIEATAVSITYQANFDTNFEDRTAYVTGMAKYIEEATVHSELNKLLEEGESYAVNLYTWRSCSRAMPAIKSNDQSNRVEIYQKFVEVIEPEVTKLVNFMYFQQRAIDAFCRDVKRLCHSEKKKDFVSESYLLTLGRLINMFAVLDALKNIKASIRNDYAAYRRAAQFLRVMADPTALRESQEVVMFLANNDKITQTLKENLVKIDGYEELLLDIINLCVDMYEARQYVVPSEKHVLVKVMAFGLFLLDTKEMVNIYKLDQRKKISLSRIDKIFKQLEVVPLYGDIQIPVFSYIKKSPNYEAHKSTWSCESGNTSQYDLLEHLVSIRDDHTRYISQLARHSNKEVTTALKDTGRSEAENRALYNLALKGLRLLSKWTSLVTELFSWKLIHPADKRSNPKIPDKAEEYEKATRYNYSSSEKFALIEVIAMIKGLQVLMTRMESVFQEAILRTTYAEVQDFTQKTLRDALRTAVKKKKNLIKTIIRAVRETCCDWTNGTEPADDPCLKGEKDPKGGYSISVKRRTVGPSSTQLYMIRTMLESLIADKGGTGKKTLRKELDGPSLEAIDEFHKRSFFYKHLLNFSETLQQCCDLSQLWYREFFLEMTMGERRQFPIDMSMPWILTDHILETKEPAMMEYILYPLDLYSDSAQYALTRFKKQFLYDEIEAEVNLCFDQLVYKLSDQIFAHYKALAASILLDKRFRTECETYGISIPYPPANRYETLLRQRHLQLLGRSIDLNRLITQRVSTAMYKSMETAIIRFESSDLTGIVELDCLLEVNRLTHSLLSKHMKLTNFGSMLREANHNVMAPYGRITLHVFWELCSDFIVSFCYNGSTERFVRTKLAFAQPQNRDKPPSSTASYIYGSKLLNTAFATVNSLNSTFIGIPHCRCIARLLGYQGIAVVMEELLKVIQKSINDYILPYVKMLMDVMPQTCKLPRFEYGTKGVVAYYSAHLQDIAQYADLKMNLFHNFQEVGNAIIFMKMMEQCLAVEEVCDLLHASPFQNIIPKPHVKQNEKLDNKLKRLEMNYAPLQVVPVVEKMGTQEQIADAREGDLLTRERLCCGLTMFEIILNRIKGFLTDEILTGPEPANGVMNIDECSEFHRLWSAFQFVYCLPLKEHNFTPEESYGEGLNWAGCTLITLLGQQKRFEALDFCYHILRVQKVDGVDADINGIPIGRLVDRIRKFQILNNQIFSVLNKYLKANESDSSPVEKIRCYQPPIHQSVVDGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVL6</accession>
    <name>A0A913ZVL6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055315.1">
        <property type="nucleotide sequence ID" value="XM_038199387.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199387.1">
        <property type="protein sequence ID" value="XP_038055315.1"/>
        <property type="gene ID" value="LOC119727500"/>
    </dbReference>
    <dbReference type="GeneID" id="119727500"/>
    <dbReference type="OMA" id="ECYQVRE"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1246"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1288"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1430"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1446"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1503"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1632" mass="181837" checksum="1EBA06987C9E8AD7" modified="2023-02-22" version="1">MSKGRGHHSVLPKIIYPQGLKEISTDLPKDELIRRLKVLARSFQDMEQEEEATQYEPLALYLVNGGFFKHPNKDVRLLVACCIADIFRVFAPEAPYRTGEQLRVIFQFLNKQLWGLENVDGPSWKRYFYLLENLAMVKSFNICMELEDCNEIFVELFNVFFSITGEQHTPKVRTFMLDVMCPLISENDAVPPDLLEIILSNLLETKKAENPHAFQMAKELIKRTATSIEPSIQAFFNNILILGKTSETELASHCYSLIYQLNTVSSTLLLSVLPQLEFKLKSNDERERLAVTKLLGQMFSNKDSDLASQNKALWNCFLGRFSDISTSIRSECVQFVQEFITHHSYLINDLIEKLQARVHDTDEGVRQEVVAAIASAAKRDITNISDEMLTLIRDRTLDKKWKIRKEAILGLAHIYKKWHNSDDLSMQERKRLSWIKDKVLHMYYQPIIEDRLLVERVFTMTLVPYTLEVKQRMKALLHLFATVDHHAVKALIEMMKNQHVVRTYVRELMETYKKDKEERAKLIHPKLVAISKQLPEPNKAIDHLKKLTSLLEEDLKARAAMEKVVDPKVTCKRAKQSVSEVLKKFGNPSQSTPTFDALKTLMERIAPLVIDANAIKELIGIVSDHVEGIADPFEERAEESTEVRGLKLLQTLAPVFPSAFRSDDSFNQLISMLKNEDDTVSDVALQIFINTGEHLKEEFPNVASCLLPILISKAKTGIPSQAKHAIRCINVVLGKNKLPVFQQLYESLQKCLNLDHEHHLTALAAVGEMARLAPEICSSMKPAIANSIVKGLLMLDQTEGSHLRGIWCHDNQVAEETLAKIAAMKLLVHWLEGLRSTQDTSPCMSTIRLLMTMIKNEGDLMERKVISPADMSRLRLAAACSMLKIAQVPGYHELVSTENFQILALMINDECYQVRERFARKLNKGLSCLRLPLSYMSIFSLCVKDPVKESRADAKQYLSKNIQNRREYLKQHTVENAHLLTLLPEYVIPYTIHLLAHDPDFSNLKDLEGLRDTKECLWFILEPLVSKSDHCNFLRKLVETIKQMKDAQNPDDRGVNKKLYAVCDIALGLLLSKTTAFAQKEHPVKPLLPKQLFTKPRKPLTNTESVLPKKMQEEFTADKKKKNPTDKLLETPPPKGAKAGKKAQKTDPTTPTSPASPAPPTPKAPRGDENKPNMVSSRRSSRTDSRSNSEAKQNDNKRKGSTRSRGSALAENNANSSMSTSSPAASPKKPQRKRPIQKPIKEFLTRSKTGTSSSSVSSPDSSPTKSPRKRPASQSRTDSPAAKKPKTKSPAVKSAQTKVAQAKAAKAKTLAVKKLRAAASPSKSSSGSPAKASTSKTTKTTGTKKTQATDKTKKSPTKAPATPVKKTYATKKSAQSPSPTKKPLSSPTKKTTASPTKNAGSKVAAAKSTAQNSGRNTVKKPTPKKITGARLSNGSISSSPKRSTLRRNSLNNKLSLASRPQRPSSSSSPQASPVRYSPRKSVLAGPLTTFQKRRAPSKPSPKKSPSSSSAKSTAASSSSEEDRRKKVKRKLDDVDGSGDKSSSSNATPPPKKLKQTTLSFNLRKASRKGSSPGVNGVDTSDEDTNESSGSTRRPSRQDRALARAIEAAGSKATMPQAKTPLSIRRSNRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVS6</accession>
    <name>A0A913ZVS6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cathepsin O</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055637.1">
        <property type="nucleotide sequence ID" value="XM_038199709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199709.1">
        <property type="protein sequence ID" value="XP_038055637.1"/>
        <property type="gene ID" value="LOC119727696"/>
    </dbReference>
    <dbReference type="GeneID" id="119727696"/>
    <dbReference type="CTD" id="1519"/>
    <dbReference type="OMA" id="QNGLCRY"/>
    <dbReference type="OrthoDB" id="498368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548321" description="Cathepsin O" evidence="2">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38429" checksum="DA16398CBD61CDF5" modified="2023-02-22" version="1">MDRTVVSWNVILIFFILVVVSSTFVSGLSPEEELFHSFIIKYGKTYRNGSTEYQKRFRNFKESLARHGQLNSYRTNPQDAFYGVTRFADLTQEEFASTLLGGRAGRRVALATRPNLRNLVEKPGPKEGIPKKFTLQGRNPPVLTAIKDQGSCGGCWAFSIVECLETQHAMDTGTLYDLSTQQVMDCNNVTSDHGCKGGSLCGTLAWLNSSKEKVVLDKNYPYKEKSETCNKAAASHGLVYLKNYTCQPYVGKEQEMVSLVYAHGPLLAAVDATSFQDYMGGIIQHHCTDTYDNHAVQIVGYDQTGPIPYYILRNSWGADWGLGGYLHIKIGGNLCGIARTVGSVDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX69</accession>
    <name>A0A913ZX69_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056114.1">
        <property type="nucleotide sequence ID" value="XM_038200186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX69"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200186.1">
        <property type="protein sequence ID" value="XP_038056114.1"/>
        <property type="gene ID" value="LOC119728113"/>
    </dbReference>
    <dbReference type="GeneID" id="119728113"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="107"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27893" checksum="94EC4D10663D36DF" modified="2023-02-22" version="1">MAAFSLGVAVRALGAHNRGECRQEDLKVPSDSVSIIAPYEAGEGGCMFFLCNGSLSIYIQGTDSYQIGKVCRQTPTMTRLLLLAFFLATFAAIVSAECPGGYTERGSSGNCYKVYNSYKKYCIYARQICKDEGGWVATIRNDEDQDWINNLYKQHRQSPCNQYYWIGANDLKNEGTFVWHQDGSAVTYTSRWEGGEPNNKDNEDCARVNSDNMSWNDEDYDRSREYCFVCEMFPRSFPWYYVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYJ6</accession>
    <name>A0A913ZYJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038056554.1">
        <property type="nucleotide sequence ID" value="XM_038200626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200626.1">
        <property type="protein sequence ID" value="XP_038056554.1"/>
        <property type="gene ID" value="LOC119728401"/>
    </dbReference>
    <dbReference type="GeneID" id="119728401"/>
    <dbReference type="OMA" id="PQYYVLH"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF63">
        <property type="entry name" value="TICK TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="5">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="152"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37701" checksum="7BA819086E21F9C0" modified="2023-02-22" version="1">MNSTQSELQRLLEENRKLKEQLAESNNNFDRQFFQDNDENVKHFTGLSSFAILDVLFTYLETFIVCSCLNKLTKFQQLVLCLIKLRLNPTYVDLGQRFNVHKSTASKTFLNIINIMYIRLMPLIFWPDREQLWETMPMSFRTHFGKQITVIIDCFEIFLERPSNLAARTSTWSSYKHNNTVKYLIGITPQGVISYLSQGWGGRASDKYVVEHSSFLHKLCPGDVVMADRGFDVSDSVGMMGAKLVLPAFRRDGPRLSGEQVENTRRVANSRIHVERVIGHLRQKYTILHSTIPMDFVISRDDNVTLLDKITVVSCSLTNMCPSVVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ52</accession>
    <name>A0A913ZZ52_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056341.1">
        <property type="nucleotide sequence ID" value="XM_038200413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200413.1">
        <property type="protein sequence ID" value="XP_038056341.1"/>
        <property type="gene ID" value="LOC119728257"/>
    </dbReference>
    <dbReference type="GeneID" id="119728257"/>
    <dbReference type="OMA" id="SKMVIYF"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF286">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="527" mass="58412" checksum="B2D761757299F57C" modified="2023-02-22" version="1">MVYSGSETVKKLQASKGQPLMMTASRTPETSLEEEFVSTTSLHGIARVANNTTRTIFRLAWLLIMLVFLGVCVAQITDRLQRFFMYKANTAISVEYVGDLDFPAVTICNFNRYRMSELTAADLRTLNYILDTNDYDYDEYGELSSFSSSWDSYPLDDDNTSAAFNYTEFTLRAGFVLDDATLLSCDWRGKNSSCSAANFSHVFTSFGNCWTFNGGSDGEPILKEIQSGAGNGLRMMIDIQQHEYSESLSGNIEAGLKVLVHDQGTPPMIDSQGFAVQPGVHAFVATRKQQFLNLEPPYGKCDASRKLTSFTKYTLEGCNIECRAQRIFEMCNCRLVRHPGTEVECTPKQTNNCAKDVLSKLKSGELPACECPVPCNYTSYITILSTAAIPSQRTAQLLIDQYDELSQYTTNLTSGSASSVSSVGESPQLLDSTYMENNWIVLDVFYENINFQLYEQSEAITSSALISDIGGQLGLFLGASFITLTEILSYLGRKLGRVLARIEPRKTATSPVCEMPAVREMETVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A015</accession>
    <name>A0A914A015_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038056666.1">
        <property type="nucleotide sequence ID" value="XM_038200738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A015"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200738.1">
        <property type="protein sequence ID" value="XP_038056666.1"/>
        <property type="gene ID" value="LOC119728482"/>
    </dbReference>
    <dbReference type="GeneID" id="119728482"/>
    <dbReference type="CTD" id="55739"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="363" mass="39301" checksum="77DC795F4BBC97D3" modified="2023-02-22" version="1">MSFALSFTRYSTRMLAIPNLIFNVTGLAQRLACKSAASHGPSLGSEAEQFNVVTTLTDSGDVLEMVKSVIPPLERSKYKGQDGRLATIGGCKEYTGAPYFAAMAALKTGCDLSHVFCAKEAAPVIKSYSPELIVHPVLDSDDGVEETCAWLPRMHTLIIGPGLGRDQALLKNVLAVIDRAKDLNIPMVIDADAVFLLGENPEAIQNYTKAILTPNIVEFNRLYRNVVGHEADPTEPVGNTMRLSQKLGNVTIVMKGENDIISNGINVLVCCGDGSGRRCGGQGDILAGAMGTFAYWAHKAHADPDRQPNEFLKHFLPTLCAAYAGCLLTKRCSTLAFHKHKRSTTTSDMMSEVSQAFCLLFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A064</accession>
    <name>A0A914A064_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASH complex subunit strumpellin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056716.1">
        <property type="nucleotide sequence ID" value="XM_038200788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A064"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200788.1">
        <property type="protein sequence ID" value="XP_038056716.1"/>
        <property type="gene ID" value="LOC119728516"/>
    </dbReference>
    <dbReference type="GeneID" id="119728516"/>
    <dbReference type="CTD" id="9897"/>
    <dbReference type="OMA" id="FFPDNWV"/>
    <dbReference type="OrthoDB" id="565118at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1161" mass="134307" checksum="001E9D3931AD551F" modified="2023-02-22" version="1">MADFLADNNLCGQTLLKLVSRGNAIIAELLRLADFIPPVFKLDNKFDQMKYGDILFDFNYFKGSEYYDNKIDSRPELQDLDEMFRENHIDILRRFYLAFEGIHKYVTDLNRFLEDLEEGVYIQQTLETVLLNEDGKQLLCESLYLYGVMLLVVDMRIDGPVRERMLVSYHRYSAAKAAVDSNMDDVCKLLRSTGFYVAPGARRPLNYPENYFKRIPISSNFIEMVIARLRSDDIYNQISAYPLPEHRSTALATQAAMLYVILYFSPETLHNQQAKMREIVDKHFPDNWMISVYMGIIVNLADMWEPYKAAKTAMNNTMDLNNVKTLTVNHNQKVGQLIKLLRQYLTEGTLTEEFVLDNIPKLMNCLRESNVNLRWLMLHTADGPWDANKKLRMMRDTMITESKYNPKMLFELLLDAAQFEFKLKEMFKKMLSEKQKKWELYKQESVERMIELGEVFSGTKPLTRVAKNDNLQAWFAEMAKQITSLNYDDSTAAGRKIVQLIQALEEVQEFHQLESNLQVRQFLLDTRKFLHQMIRTINIKEEVLITMQIVADLSYAWELIDTYTPYMQQGIKGNPGLVTKLRATFLKLASALDLPLIRINLANSPDLISVSQYYSSELVAYVRKVLQIIPQTMFSLLSQIIQLQTHHIKEVPTRLEKEKLRDFAQLDLRYEVARLTHSISVFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVQQVASALHHGIMFNPKAKTSELMQRLDALGAKMDGFVRSFEYIQDYVNIHGLKIWQEEVSRIINYNMEQECNSFLRTKVHDWQSIYQSPTIPIPKFQPVDGSINFMGRLVREILRITDPRSTSYIDQMKTWYDVKTKQEVLDIKVFSKVRQSIGTCGLTGLDRLMCFMMVRELQQFLRYMEHGVLREKSWLEMFGTLMKTLNPVRGLISNPGKVYSHYVTRANKMWAPFVNLVLKLGQMQLLRRQIANELNFSCKFESKFLASALETMNIGLLADVEAHYHDPSRPYPKDDNPLMFELASYLESAGISNPLSKIYVTTKRLPYFSLFTFLFVVSQLPKFQYLKTVGSMIGKLPKDPLDGPPLVVGTLTLLRQFHSETTDQFLALLGQYVRSSVESTAAGGKASELTPEVINVLAFLDDFTYYAGLSRQTVETHIPAYIFDEFKSTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A289</accession>
    <name>A0A914A289_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057476.1">
        <property type="nucleotide sequence ID" value="XM_038201548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A289"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201548.1">
        <property type="protein sequence ID" value="XP_038057476.1"/>
        <property type="gene ID" value="LOC119729048"/>
    </dbReference>
    <dbReference type="GeneID" id="119729048"/>
    <dbReference type="CTD" id="51160"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="26162" checksum="3013B5723928D4A9" modified="2023-02-22" version="1">MFSTVPTTQSSQNQSSSANRPELYEEVKLFRNFREREKYDNMAELFAVINTLQWLEKAYIRDAITPKEYTAACSKLLVQYKAAFKQVQSDQIPTVEAFMKKYRMDCPAAMERIKEDRPITIKNDDGNTSECIAQIVSLFITVMDKLRLDMKAVDEIEPELRELGETMNKMNLLTEDFQGKEKVSSWLKTMSSMRASDELDEDQIRQMLHDLDSAYQSFIRMLGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A374</accession>
    <name>A0A914A374_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058120.1">
        <property type="nucleotide sequence ID" value="XM_038202192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A374"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202192.1">
        <property type="protein sequence ID" value="XP_038058120.1"/>
        <property type="gene ID" value="LOC119729579"/>
    </dbReference>
    <dbReference type="GeneID" id="119729579"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077740" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="186"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="35570" checksum="A751D86FDC5655A7" modified="2023-02-22" version="1">MYLGQIVLLLLTFLCEYSLSYNGGTQGDNILQVCENSGAKTFVKYARATPWVNNTLVNGTGYMALCPTDHAFATLPPVVKDALKDPQTVEWYLRYHIALTVAYLREIDNNLRIPSAFRPPGKTEDLPEAVLPIRFNIYDVLADDRSDGKFGKVVTASGAQIVAADKIASNGIVHIIDKVMFPLPTGADVVEFIRDDGRFSTLYGFLEKANLTQALMTDPSRPLTVFAPNNQAFTNIPKPIMDKLMTNATYLQDVLEYHVAMGAYYAAGLYDNQTLMSLYRKPLLVQRGVGGIYVQDAKVLQADNTVSNGVVHEISAVMIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5Q1</accession>
    <name>A0A914A5Q1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059133.1">
        <property type="nucleotide sequence ID" value="XM_038203205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5Q1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203205.1">
        <property type="protein sequence ID" value="XP_038059133.1"/>
        <property type="gene ID" value="LOC119730353"/>
    </dbReference>
    <dbReference type="GeneID" id="119730353"/>
    <dbReference type="OMA" id="TAMDEPW"/>
    <dbReference type="OrthoDB" id="774873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14321">
        <property type="entry name" value="UBA_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048875">
        <property type="entry name" value="BIRC2-3-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21290">
        <property type="entry name" value="UBA_BIRC2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="758" mass="84435" checksum="0E6EB6113B3D492F" modified="2023-02-22" version="1">MMQFDETDQSRLGQPKQLLLQLNGLTSSSISAEDIKLSVDKLTELSNMDNNGAGKKDHIPRPNQVRVDGAGNVSIIGSNNIVTVFDGKPVKNETPSLASLNMEQEMNRLATFKNWPHSAPVTANALARAGFFFLGIGDQVQCFACLGIIKDWEFGDHAMGEHKKHFPRCPFVRDPTYKNVPLVAEQAKSGAAGGAPAEKRAKEKAAELYKAPNNAKKSQSGKKGSGKPVKGGGFNESLKSCEGNPTRQPTIDSAETEVRLTFRSEYKRLLSYHSWPRNHPMDPRDLAKAGFYFLEKDDIVQCFACFGKIRDWEPQDIPRQEHTRHFPSCPFVKGLDVKNEPITDLQMANAVSIAYREPSGYENTLQQFSKQLEAALPQTAKVTSQWEQVASPNRVLNRPKYPDYAGENARVATYANGWPGILGITPQQLARAGFFYTGEGDSTKCFYCGGGLKHWESTDEPWTEHAKWFSVCEWLLQQRGRTFVSYVVRNFPVDTSQLRQARNTQSAAPTSAPAPAPTPAKAAKVATSPRPTASASQEPPEDEAGVIYKKFAKDDPLDEAMNSRLTKRVLEMGYDANLVKQVVRRQLRTAGKAFENTNDLLEAVWQAEELREAGKWEEDVEEEEVEEFRGGAKGGAEKFIAQVPEKRSKDAGRGEDELGVLTQKLEGMRVGEHQATATVGQTRVEPTEWQHQQTPEEIEREIERLRDEKLCKVCMDNDANTVLMPCTHLVVCDMCANSLRYCPICRQTITNVVKVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7L2</accession>
    <name>A0A914A7L2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-glucosylgalactosylhydroxylysine glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.107</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acid trehalase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(5R)-5-O-[alpha-D-glucosyl-(1-&gt;2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12753"/>
            <dbReference type="Rhea" id="RHEA-COMP:12754"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:133443"/>
            <dbReference type="ChEBI" id="CHEBI:133452"/>
            <dbReference type="EC" id="3.2.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.107" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038059780.1">
        <property type="nucleotide sequence ID" value="XM_038203852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7L2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203852.1">
        <property type="protein sequence ID" value="XP_038059780.1"/>
        <property type="gene ID" value="LOC119730818"/>
    </dbReference>
    <dbReference type="GeneID" id="119730818"/>
    <dbReference type="CTD" id="80162"/>
    <dbReference type="OMA" id="PAMTYSM"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047402">
        <property type="term" value="F:protein-glucosylgalactosylhydroxylysine glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000023">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="10">
        <location>
            <begin position="336"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="734" mass="82132" checksum="01FE046C314C5E0E" modified="2023-02-22" version="1">MVTDGAVSEILVYPTMFLSASCVFALTLSWLIVTNTNACPCNQKYKDISPSANVFESAVLPNETCCLPAVGNGYLATVVYSDTIYVNGVYNGRGGASHRARIPSTAAIQVSLPSNVSVSKESYSLDLENGTFHRKVTTKEALIEQRLYAHQELSYILVNQIIISRRGPTTDPIILKLVNNTGINSKDINFKNTAPDEGTRMMYGNTVESETSTSSTISVAVNWTIIPDSITLPSNQDSKTWTFITAIGPNRMIAVASHMHATQMALEGILYSNHCRAWQDKWLHGQIEVDDITLSKAIHGSMYYILSSLPSLNYDVQTTPYHFYGLSPGGLAHGRIATDYQGHVFWDQETWMYPTMLLFHPKLGRAMLESRTYHLDAAKELAKSRGYQGAEYPWEMAYTGAEVCPAEIYSLQEIHINGDISFAVQQYLHVLRDVDFLKNRRGYEMISELAKYWESRVEFNNASGYYEIKGVKPPDEYHSNVNNSVYTNSVAQVSLLLPAYAGKFINVTAPPAWTEIADKLLILYNTTHEYHPEYEGYEIGTTVKQADSILLGFPLNVKMDNVSRYNDLQTYQPVTDPNGPAMSWSMFSIGYGEVQQPDKQREMFLRNFKNIQQPFRVWTETASGHGAVNFITGMGGFLQSVLFGYGGFRILPDHLLFNFDLPKGTTKFEVRGLDYLGSEIDFIATEKTVLVTLTDQQQGAAKLQMETAQGTVYDLVKGKPVLINRISWALIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A850</accession>
    <name>A0A914A850_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059953.1">
        <property type="nucleotide sequence ID" value="XM_038204025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A850"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204025.1">
        <property type="protein sequence ID" value="XP_038059953.1"/>
        <property type="gene ID" value="LOC119730954"/>
    </dbReference>
    <dbReference type="GeneID" id="119730954"/>
    <dbReference type="OMA" id="YIIPGDC"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="54166" checksum="755997B330F8CAE3" modified="2023-02-22" version="1">MTVTARNGRKGPGETGSGGSSDSLNSSVENESMESTVQLKREVGLVRAVSLIVGAMIGSGIFISPKGVLLSANSVGMSLVVWFLCAVISALGGMCFAELGAVVPLAGGQYQYVLHAYGNLPGFMVAWSLVVIMKPGSVALTAITLGTYISDYVIAGDCAPPREAVQLFAILTVMLIAFINCVGVRLASGLSVVFSGAKVIALMVIIIAGLVKVSQGHTEYLDPSVSFEGSSTQFLGYGLAFYYGFWAYGGWEILNSITEELRNPSRNIPLAIGIAIPVVTTIYLLTNIAYFTTLSPTELLASSAVAVTFAERTLGSMAWVIPLGVCISTFGHLLGSILAAPRTAFAAGREGHMLKVLSMINVKRYTPLPAIVLQATISIVFILLGDFKSILIFSGFVNYIFDGATFMAVLILRRKYPDKPRPFRVNILIPIIATVVCVFMILAPLISDPTWEYLYAFVVMAIGLLVYLVFVWGKRQLPFMNHTTLFLQKFLLVTTSTEDSSIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABQ3</accession>
    <name>A0A914ABQ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060784.1">
        <property type="nucleotide sequence ID" value="XM_038204856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABQ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204856.1">
        <property type="protein sequence ID" value="XP_038060784.1"/>
        <property type="gene ID" value="LOC119731650"/>
    </dbReference>
    <dbReference type="GeneID" id="119731650"/>
    <dbReference type="OMA" id="FLTINSH"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF10">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19876" checksum="ACC0E4DDD614C912" modified="2023-02-22" version="1">MFPDSYTGITGYTAHIRLKQDAQPVYYRPRPVPYALKQQVEEELDKLERNGVLVKTDQSDWATPVVVVPKADKTVRPCGDYKVTINQAVDDEQYPLPTSQDLYAELSGARVFTKLDLSHAYAQLNVDKESQPFLTINSHKGLYSYTKLPYGVKIPKDLPVCHGQNAARHSSLLVQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABR0</accession>
    <name>A0A914ABR0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase subunit S1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061345.1">
        <property type="nucleotide sequence ID" value="XM_038205417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205417.1">
        <property type="protein sequence ID" value="XP_038061345.1"/>
        <property type="gene ID" value="LOC119732051"/>
    </dbReference>
    <dbReference type="GeneID" id="119732051"/>
    <dbReference type="OMA" id="MSQRFYP"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046755">
        <property type="entry name" value="VAS1_LD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF7">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05827">
        <property type="entry name" value="VAS1_LD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037263373" description="V-type proton ATPase subunit S1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1 luminal" evidence="8">
        <location>
            <begin position="284"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="9">
        <location>
            <begin position="408"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49939" checksum="C5868E7496F5A5A1" modified="2023-02-22" version="1">MEGTLKFVLHILAIFSPVLCFGEQPVPLIAWSNTRSFANKPRISAGKLVTREELGTNYMSSILQTQPQNIFLFVFDELSIDDITKYSNAYSADGQGGALSNLKKAMTESLSNLVLPSVEPGDLESDLSSKVTGAVIDLKDPTLEGVTLDPTKTNLVVTRFSVSSGDSKEKAFNEADKLIASMIRGQKTHYTAILTANHKSVLKPQSDDRLTVGRHLLQAPAAEPFFGSYIGKDPDCSIYMTANAFTLTVGPKSSKPKPVTLPTTGWLFSNSSCDIEEIKGKQYLVVKFEMELKTNPQGLNDFKMSLVFNSTVSTVAASHSYFWSVTSASFVEFAVDDGQLIRYDVQTGITDTPQDFSFHCTDSVFTLTQADKGTASAQLAITELQVQPTGVKTVKDVPQFGTANDCVGFFTEGIWMGLFTGLILLLILSFGVGMISNLRVMDKFDDPKGKTITVNVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC07</accession>
    <name>A0A914AC07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060874.1">
        <property type="nucleotide sequence ID" value="XM_038204946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204946.1">
        <property type="protein sequence ID" value="XP_038060874.1"/>
        <property type="gene ID" value="LOC119731719"/>
    </dbReference>
    <dbReference type="GeneID" id="119731719"/>
    <dbReference type="OMA" id="INCCPAR"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="206" mass="22553" checksum="0738CF7D27E148DB" modified="2023-02-22" version="1">MAASNLLLVGVESKQRVCYSGPPPEPDPDNPDDRMKQVMQQIRKRCPGRRPPDCSSPQPLGMEDGRIPDGRIKASSHWGSINCCPAREARLNNDLRWIALSTDANPWIEVDLVESTVVTGVITQGSGGGSYVTQFKVAYQKQPSSDREHVKDKSGNVKVFIGNTDVSTTVTNLFDESVVAAVVRIEPTEWQVGVGLRLELLGCHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACF0</accession>
    <name>A0A914ACF0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061019.1">
        <property type="nucleotide sequence ID" value="XM_038205091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205091.1">
        <property type="protein sequence ID" value="XP_038061019.1"/>
        <property type="gene ID" value="LOC119731819"/>
    </dbReference>
    <dbReference type="GeneID" id="119731819"/>
    <dbReference type="OMA" id="ILMSVNC"/>
    <dbReference type="OrthoDB" id="10039923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="64"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="378" mass="41727" checksum="1EB35A9BB24D6631" modified="2023-02-22" version="1">MEAYKNVDVTVATSTDVVNSSAARTTSFPTNSSLPSTAESIYTYPELVFCAVGFFILVAGTLIGNSLVLVAVARTKKLQNVTNVFVVNLSVSDCLSGFAFLWSVPGMVSTTPGYPLHTDVPCIISAVFVLMAVSCSLNTLANIALNRCILITRSVETYQWLYTPKKIALMVLGSWLVPLCAAIIPPLSGIGDLGFDPESRTCSDIDTHPKGATYDKIQFAFFYPLPFAVIFVSYVLIWRYVKKHFRKRRQQMSERLQSSTVVQTAPSSISMLEIDDSTSRRTRNQQASLRRTGSSRQLTSSKHDQLAITKNLFVVVLAFVVCFTPLAIMVVTKSQRYQLYSALILFLSGCINPLIYAAKHPHFSPVLRAMVRCRSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF26</accession>
    <name>A0A914AF26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062313.1">
        <property type="nucleotide sequence ID" value="XM_038206385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206385.1">
        <property type="protein sequence ID" value="XP_038062313.1"/>
        <property type="gene ID" value="LOC119732779"/>
    </dbReference>
    <dbReference type="GeneID" id="119732779"/>
    <dbReference type="OMA" id="MEGHINA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZAD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="25919" checksum="39D476600C786525" modified="2023-02-22" version="1">MEGHINALAMMCRICGQIITSAKNKSSSAKYKTQLLAVYNLNLDEEQGGIHPPSVCNKCRQQVQRAHSSMEQGKQYQGKLPQIQNFSAHDAACWVCSACTAHVAQLRPQFAAHQSSSSDQPDQPESQPSTSAQDPASSQPSLSTATRTLFRDTAPDPGMASHGKKRVWASLNHVRRDYAHKRTKEASVFISDFCERQKEDKLDLLYFLLCDNPNECGDSRYKEVLASWSKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFQ9</accession>
    <name>A0A914AFQ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062572.1">
        <property type="nucleotide sequence ID" value="XM_038206644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFQ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206644.1">
        <property type="protein sequence ID" value="XP_038062572.1"/>
        <property type="gene ID" value="LOC119733063"/>
    </dbReference>
    <dbReference type="GeneID" id="119733063"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037297674" evidence="2">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="462" mass="51097" checksum="BA4C7B59F36A7600" modified="2023-02-22" version="1">MGGLLQALLVVVSLQGCHCGEAHSSHVRDLTLSVKATENGSQDTVDVSPSQHDEQPAIKSLQCSYSASPPVILETWPDPAVTRIPHTADWTFHFKFNQNVNRATRPAFVKVYYRVGAWVFSIDASAGDNVHFPAPDTLQVVVPANLKALLAGGQVFHVLLDEGVVTGPGPCYVPSAAVTDPNFYKVLYSGLPDRYYDTPYNTTSAPPSSCSDTERPTVIQSWPADGFYSSLSIAKLTLKYDREVTVAQSLTGVYIYRRHAWQSAQNCKIVQTAVDTIETDCYSPMNLDLYDLDGNGVFTIIMAEDVVTGPAPCNAPSGWLAITLYTGSPPATDGAPTYAYTTEQFGDWTTRDNPGFQPTTEYWPTTQEVTESPFTEPATTPWMDCASMAYPAVVEAWADATVSPYYSWIWNFRFDQHLLMRSQYTPLMYLRIQPHHRNLTTLPNSLQNSQHRRSDGLPTNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGJ7</accession>
    <name>A0A914AGJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063110.1">
        <property type="nucleotide sequence ID" value="XM_038207182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207182.1">
        <property type="protein sequence ID" value="XP_038063110.1"/>
        <property type="gene ID" value="LOC119733812"/>
    </dbReference>
    <dbReference type="GeneID" id="119733812"/>
    <dbReference type="CTD" id="26005"/>
    <dbReference type="OMA" id="CYMPVVD"/>
    <dbReference type="OrthoDB" id="79771at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2083"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1594"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1681"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1787"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1843"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2033"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2110"/>
            <end position="2120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2151" mass="237014" checksum="9160C4E67D8EEBAF" modified="2023-02-22" version="1">MEKASENARLRRRHSSMSEAASSDSDASRTSRVSFQEPLVEKEVNPADGLSVQRLTLLGRIHIARVMIDSLTLRTPPGGGTPDVRPSRGGRGRGRPPRPSTKPKTKKCTYFVEYRFPVTASPREQSLVNNMATEVMRLASKKVDSNGEITFGHRSVFPVRFDGTAVDSWWKQLLVFKIFSRTAGQKSPVFLGVASLPLRSVLQSPDLSLLNIEVDARDKTQSDSPTITGADESSASGSAKDAVVGTLKMSIELASDSKDFPTALARMKLAELRGAKICPLPSNQPHLPIKIPTGSVESDSKSSSRSVQTDSLAAQVAESTSGDKDEPPTSGREPTEGVKTSNGHSQPQPSRKQAQRGEERLQEQPSRQMTDEKIYVNSQDDAAPKTKTQYEARTLHSLLSIPEGRAVTFHGVAPLISGSNIPHVPPQPHAGLGVGISGLGGRDQTTRNTYLVCRLFWSDDSVRSNVCWGTTEPDYNFMQVSPVLLTPSLLERARNNCMVIEVWDKKTSAQNDQLVGIAKLPLHQFYMSFRDERIASTLLKSQYPVVAVDNYVNIVDPFTGVQYGQLKVLLALGSSEQISALQRLKCDKDALDTRPSRPGHYLERGEAVTRNMAEQDSTQDELVEHIFEVVVEGVRGLPQLEDTVWGEADCFVQYHFPSQSPPRGAPDSANTMSVGPILAPHQTPTTLCMPDPTFHDVSRHRLQLPRGTPVQRELLTACAGVGGGAGGIPFEVWCRYYYPNIRDQVVAKTSLPLAKLCAMVTMQRRGEPSVQTFSLPLRLQHPDQDSLTKEQIAKLQDAGLLDVTVNYRHNVVQGGGSIPRGRETGGPQVCLSVGVLRACGLKSAAVSLAQFDSSLQYASEVGVNAYIKMELSFLSKQDVRITQTVARTFAPEFSHHVDFPCPLLFDDQDSDQLSLAEALETAEMKLEVWHQVPGFKSDHDANFVTIDSGTNKAAGISAHRLFAPTGDILLGTAMVPLQAILSHRTGLQGWYPLSIPAPGWTNQPSVHHSGHPPDHSASDSPQASRGRGLDRVGGGLELSIKFAHQGDRDRVIDAGRRVGWSPDVELEGLEELWDDEGASAGSYSAEINVNIDSAWFPVHAALRPGQQALDTAAKAYIRYKLYDKGSICSKLCYLDANDENYITADLKHGHHFHTALTQPLAWYLREERLEIQLWVSYNGELSPTDTGHTRPRQRDKLIGCAYVDMSALCDKRIKQRRISGLYPLFRPGASDLGGSCMRVHLSLKHAHVDSHRQQESADEAKMPLRDGIRQIHPSRPHHQEHPVDAEEEAARRQEDERRQREEEEEQETRREMTKPVLMGVAVERAMHLVSVPSSNRLEDSLPSCYVTFQSADGNPIHTPTVPNSAQPVWGFEQEVKISAEVLDRQSFIFKVWHQTSSEPDMNSDRMLGFASVDLAPLLAGFRSLNGWYNILDFGGHCRGQIKVSITPRESVSPLKRSPKPKTSPNTSAILAQGFPHIPLTTLSSSSSHPPSLPARSSSPPKSTNPPSNHYQEHLQNVRKFHADLHDRLQTRQPDSTTSEQGRDSRRGTKTAAVVSLGDGGLLPSSVSSSFLMQNLRKNLTELDSVYHRLQQRLAHDPSPDSVSHPENKPSDEQVHIPRLPTEKIPNNDNVENSNQQVQYSTGDRTNDPTHRRTSDEDILEKIRADLRQEDAEYISDDDAVREETGGRNHYSEMEEPASPQVESDWEDSVQFQDRREDRESEPEEDIIIVPRPLNDISSANFSNGVRPDANVGPQIHQGGEQDLDGVNQSQQDDKVEDNSDSGTSRQQKFDENDEELGHASDFLGAGHELDLEPGLTDQFRTGMGDGRLPMESNGRTGVAGKGLESEIAKSDSEDDKNRADTDHVHLDRDAIADENAQHPSERSSSNSENHMQSLIPPTSKVSSKSQDDSGGEDSNFGSDNMAGMRPEHQILEHSDKSQDISRRGDHATPRIIADTDKDQTMGRNANDRRVAESSGASDRDAGRGSKSRSNEDWPEQKVREGAKEDGGGGSPDESSDESVVITIDSRQAEKQTVAGTRTEQPGNVNLSSSHSPPAQLPNFFLPTRDLEASMRALHNVTSILPRVQPRLVEDSDEATSRPTDAAKELTQRLASRHSSSRSRVSRPSSKPAYKLPTAEEARRIAKIFASRFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGN9</accession>
    <name>A0A914AGN9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062554.1">
        <property type="nucleotide sequence ID" value="XM_038206626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206626.1">
        <property type="protein sequence ID" value="XP_038062554.1"/>
        <property type="gene ID" value="LOC119733045"/>
    </dbReference>
    <dbReference type="GeneID" id="119733045"/>
    <dbReference type="OMA" id="YWSSFDL"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="31208" checksum="A52877C841E3B000" modified="2023-02-22" version="1">MGNNQSNTSLPIEGRGGWVVFENDWFAEGRSRRVYRGTYQGERHMMGRCVVKIYKEQWSVRLGEMSYRADIRATDRAQEMAKLFNSTYMINGYSIEFTKLEIARINSSAGFRFLGFVRIPKRVKGKEADERVSSSVMIPKGDSVVIENYLEGEFIHFLSNTAYQDEEVQDTVSAAFSHFTYQASNGQILVCDLKGVRGERGYVFTDPAIHSHIDPGNYGSADLGDVGILKFFENHTCCALCEGFQKLDPADVTSRVRRQARALTPGRSTTHLHEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHJ9</accession>
    <name>A0A914AHJ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063006.1">
        <property type="nucleotide sequence ID" value="XM_038207078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207078.1">
        <property type="protein sequence ID" value="XP_038063006.1"/>
        <property type="gene ID" value="LOC119733689"/>
    </dbReference>
    <dbReference type="GeneID" id="119733689"/>
    <dbReference type="OMA" id="ARNCEFH"/>
    <dbReference type="OrthoDB" id="10053045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="296"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="9">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70657" checksum="0FF2C67FD7D1E541" modified="2023-02-22" version="1">MDIFEILSETGSTYESGKDALTKYFEPRKNIEYERFVFREAKQLHNETVADYATRLQQLARNCEFHDKDTEVKSQIIHGCKSSKLRRHALRESELILVKLLTTARTYDLSEVQANGMEQHTQPSRDSTNRVTTTKSHTRNRESIKGPHALNPDTLYPVGTAERLRAHSKTAVAYETSHVNSTFFVTKTTKDTLISFIHVIIHVAYNLQPDDPPKLADKLMNQYADRFTGIGMLKNIQCKLHEDKTVQLIALPHCRIPYHVRKKVENELEKLLCLDIIAQVRNEPTSWVPPIHVVEKPHRPGEIRMCVDMRNVNTAIKRERHITPTIDVILAQVNGSTVFSKFDVNAGYHQVELAPESRHLTVFSTHKGLFCYKRLNFGVCSAAEVFQDAISSALRGLAGTLNISDDILVFGRTQQERDARLAACLQRLRECNPTLNKDKCRFGKSRVEYSGHVFSSTGISPDKKKVDAIQNVSEPTNASEVRSFLGMITNFIVITDHKPLVPLFNNPHSNAPTRIERWLLKLQEYNFTVEYQQEKLNPADYMSRHPHEQPRTTSRKQRLAEEHVNFISANAVPEFVTFDTIRTATRKDPVFQSAIDALTTHSWDTLLKNPHSQQTLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHL6</accession>
    <name>A0A914AHL6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063490.1">
        <property type="nucleotide sequence ID" value="XM_038207562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207562.1">
        <property type="protein sequence ID" value="XP_038063490.1"/>
        <property type="gene ID" value="LOC119734204"/>
    </dbReference>
    <dbReference type="GeneID" id="119734204"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037041655" description="HIT domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16985" checksum="23CBF96EB53520B2" modified="2023-02-22" version="1">MNLLIVLMLGACAAVALADDSKELEALMQAINSNENGATLKNRIQWGFPHVHVHLPHIAWGHVHLHLPHKRDESNVKSDDAKSLEALMQAIDSKEYGETMDAFPPGLKNRIQWGLPHIHIHPYHKRDEHKSDEFQAEDDATSFRPRPAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI85</accession>
    <name>A0A914AI85_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063104.1">
        <property type="nucleotide sequence ID" value="XM_038207176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207176.1">
        <property type="protein sequence ID" value="XP_038063104.1"/>
        <property type="gene ID" value="LOC119733806"/>
    </dbReference>
    <dbReference type="GeneID" id="119733806"/>
    <dbReference type="OMA" id="CLYCFIC"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF10">
        <property type="entry name" value="EG:4F1.1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="286" mass="31309" checksum="BE542E0C44EE12AC" modified="2023-02-22" version="1">MASYSNMTPGASRHRHQETVYKVGIYGWRKRCLYLLILVLTSVIIVNVALTIWILRVMNFTMSGIGKLHLSSKGVTIGGEAEFLKALYAAEIKSRQDKNLVLQSARNVTINARNGLENTTKGRLIVGPESLVSYNDRFVIYDTKNKMLFYADENEVVIGAKRVTFTGSEGTAFKGPIQTPHVTSESGQDLRLESVSSNLIVESPQTVSLTSPIGQVSVSCFNDINLRSRQGKISLDAAHVEIKNLQESASGTSSDADVFELCACRNGRLFLAPPTTGCQARAELCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIL0</accession>
    <name>A0A914AIL0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063488.1">
        <property type="nucleotide sequence ID" value="XM_038207560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIL0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207560.1">
        <property type="protein sequence ID" value="XP_038063488.1"/>
        <property type="gene ID" value="LOC119734203"/>
    </dbReference>
    <dbReference type="GeneID" id="119734203"/>
    <dbReference type="OMA" id="QFFMTFF"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="519"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="794" mass="89393" checksum="07FFAF40836AE8B0" modified="2023-02-22" version="1">MSGVSNNGEVSSPPADDLYTSNNNETVKVELPYAATVPVTDSGGVEQGNGTINGPAMYHQPDLAPGDGPETDALTGRPVTRQGTMGGTYSRQHCHNAIEFELHKLDVQGDKEDAVESRAKIIREMPATLHKKRELRNQYGKRKVKAVSGWKSFKYNTALKWKHFKEKLYDVVLTFEVWRASLKEVEGKFGTAVVSYFVFLKWMLFLNIYIFVLMFGFVIIPQVILGGGYIESTTCEAEYTSSVDQQCNTGNTGQCIIDFIGGTGWMEQTALFYGDYPPSFSNDNSTDITVFLDNVYMLPLAYLLTSAGYFLLSLLLMVQYTAAGFKESLGNTEDYHFKYCNKIFAAWDYSMTDEKNAYLKHRSIHYILQTDLEEARLKLLRANRTTLKKCRLYLLRLILNVVVLAILGGAGYLIYYTTDLSVLHSNMPITTNAVGSLLIGYLPSITITILNGLVPMIFNVVVRFEDYSPQFEISMTLVRTVFLRLASLGVLFFSLFPQISCSETAEDTCGVCSAGDLKCWETYIGQEFYKLSITDFAAVVLVVLLWEFPRKIAAKYLHFGIVQTLGKMEFEIPKNVLAIVYSQALCWIGSFYCPFLPAISLVKCLVFFYLKKWSLLYNMVPSSRPFRASRSGIFFMVILLITFMGCIIPVGYSIGAIEPSRGCGPFRGQVTMWAVITTTIEQFNNFFEEVFKFIGSAAFVVPCIVVLLLILYYYHAIASAHNELVNRLKEQLIMEGRDKHFLLTRLHELEPNTKGHKKRHILPQKSQKTHPPKHPSQAWSGGGPMDAHPFSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMQ7</accession>
    <name>A0A914AMQ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein Skeletor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065022.1">
        <property type="nucleotide sequence ID" value="XM_038209094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065031.1">
        <property type="nucleotide sequence ID" value="XM_038209103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209094.1">
        <property type="protein sequence ID" value="XP_038065022.1"/>
        <property type="gene ID" value="LOC119735394"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209103.1">
        <property type="protein sequence ID" value="XP_038065031.1"/>
        <property type="gene ID" value="LOC119735394"/>
    </dbReference>
    <dbReference type="GeneID" id="119735394"/>
    <dbReference type="OMA" id="NARIGPT"/>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057443">
        <property type="entry name" value="At5g54830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275695" description="Protein Skeletor" evidence="2">
        <location>
            <begin position="18"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="138"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="276"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71221" checksum="5CBBD86176447C5D" modified="2023-02-22" version="1">MQWLVGLLLVQVSITVAEPYYGKEIGVLRTVFHGVSGTVRAADSQTLVIENFNYDGTAPDAFVWIGTTSQPDSTGTIAPVVPGSETKLGEYRGTNLVAYLPGSMTVQDYKWISIWCRNFSANFGDVYIPDSFRNPAPHDLGALPTRAHRVKADNVQIKDARTLIVTNLFYDGNGPDAYFWADTSNRLTSQGTKLIFRPGLSNAGSNQRLRVALDGEDFTVAMPPRMTIYDFKSFGLWCVAATQNFGSIAFDPATINVPAVLDPPPTYPNCEVLLEDEFQVQWRINAEDSSITVEMAGRVTPGNYLAFGLSGSENETLMDGSDVVVGWLDENTMSPMVVDYNLQSKAQCSINDGRGACPDDIQSVGGANNVMLGDVLFDGGIKRLSYKRPLDTGDSTDQVIPTDRPVFISWAIGPINPDGRVAKHVRAPSGDIQINFGRGSSSCPALTDSTGGGSQLPAWPAPTIKDVTEFRVEIGQSGGVRGYTGITGKTGWGIAWYVNGLLIPEITVKRGVNYTFTVFGGDDSEKSAQYHPFYITDDSEGGYAQKTSQGKASVTIYAGETEGPYCSWQESESGVNADDYNSFDAYKMKLERVCTGSSTNGGKLYWTPDENTPDVVYYQCYTHRFLGWKINVSSASGLEISLTLLLAMLGFVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARN6</accession>
    <name>A0A914ARN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066715.1">
        <property type="nucleotide sequence ID" value="XM_038210787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210787.1">
        <property type="protein sequence ID" value="XP_038066715.1"/>
        <property type="gene ID" value="LOC119736778"/>
    </dbReference>
    <dbReference type="GeneID" id="119736778"/>
    <dbReference type="OMA" id="SHERRCI"/>
    <dbReference type="OrthoDB" id="410381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="530"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="962" mass="108362" checksum="FB2360BA7B280A3F" modified="2023-02-22" version="1">MEGHSCCRWLAPFWGEKGAECVSLPCQYIASPSPRLLQCLLVATHGNWASCDPRLNCRGSRSSSGPQRHGVQAHRRVDTPWRHEISDSRKTAVINNELLRLQVDIAAVQETRLLGSGTLRERDFTFFWQGKGPEEIREHGVGFAVRSTLIGMTEPCERGTERILTLRLHTTDGPVNLVSAYAPTLYSSQEAKDEFYDQLQTVIQGIPSRELLLLLGDVNARVGADRDSWPTCLGRRDHLRNVLTTRSYQSADCDTDHSLVCCKIRLQPKKMHQAKPLGKPRIDVIKTSHPKRVESFTKSPEEALFTDPPEGDAQQRWSQLRQIIYNSALQAFGKKQKKTQDWFEANSSELNPVIEEKHAALLEHKRNPSQATQQALKSARSKVQKRARRCANDYWLQLCKDIQTSADTGNIRGVYDGIKRAMGPTQTKVAPLKSSTGEVIKDKAKQMDRWVEHYSELYSRENIVSDDAFDAIDSLPCMMELDVPPTVMELRKAIDNLPTGKAPGLDGIPPEAIKCAKGVLLSHLFELLCQCWTEGQVPQDMRDSNIVTLYKNKGDRSDCNNYRGISLLNIVGKVYARVILNRLQKLADRVYPESQCGFRSRRSTIDMVFSLRQLQERCREQRQPLYIAFIDLTKAFDLVSRDGLFRILAKIGCPPKLLSVIQAFHTDMKGVVQFDGASSKAFSICNGVKQGCVLAPTLFGIFFAVMLKHAFGSSTEGVYLHTRSDGRLFNLSRLKAKTKVRKAVIRDMLFADDAALATHTEQQLQSLMDSFSCACLDFGMNISIKKTEVLGQGVEQPPVISANNSKLEVVHEFTYLGSTVSDDLSLDIEINRRIGRAASTFARLTERVWENGKLTIHTKTAVYRTCVLSTLLYGSESWALYSRQEKRLNTFHLRNLRRILGIKWSDHVTNTEVLAQAGIQSLVTLLQQRRLRWLGHVYRMPEGRIPKVLLYGELASGKISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUI9</accession>
    <name>A0A914AUI9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038067323.1">
        <property type="nucleotide sequence ID" value="XM_038211395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUI9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211395.1">
        <property type="protein sequence ID" value="XP_038067323.1"/>
        <property type="gene ID" value="LOC119737211"/>
    </dbReference>
    <dbReference type="GeneID" id="119737211"/>
    <dbReference type="OMA" id="HFFTFKD"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034654">
        <property type="term" value="P:nucleobase-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090407">
        <property type="term" value="P:organophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000036">
        <property type="entry name" value="Nudix hydrolase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="305" mass="34078" checksum="9737D243CA710907" modified="2023-02-22" version="1">MDSNNEKAGSSKFYCTMLRAHGLVFTKLRIFLFKTHHSKTLLSSLHPSRCLQGMAEVSSPSSSAFTEPTKDDVIARLRQTDAADMLAGLPPLPTSVPRAAVLVPLFYRNSQLHVLLTVRSSNLSSHRGEVAFPGGKSDEGDADLRETALRESEEEIGLARDRVEIISQLSSVFARRGTLVVPFVGFIPEDFDPVPNPEEVQDVFTVPFATFLQSSEDHKQRVWTDSGQEFLLDFFTHYQDGKQITTFGLTAIICITAASICFGRSPDFESLIKFDSSNPRKIHEISKKSYMRQVRKYEKAKQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVU0</accession>
    <name>A0A914AVU0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067371.1">
        <property type="nucleotide sequence ID" value="XM_038211443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211443.1">
        <property type="protein sequence ID" value="XP_038067371.1"/>
        <property type="gene ID" value="LOC119737245"/>
    </dbReference>
    <dbReference type="GeneID" id="119737245"/>
    <dbReference type="OMA" id="CQPNRVL"/>
    <dbReference type="OrthoDB" id="10400844at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="17942" checksum="7DBBC94C02859C2F" modified="2023-02-22" version="1">MYVWCGLPWATGAGLVAFVMLVVFTPGTLQQTGVARIELCQPNRVLPSYLQDACNELLANRGTAQSAMADSGTGASPPDRRPLSDPPRYGRRSGGSAPLSVHLSKRLYSLPTVKLYNVTDRRRHQGNGRGAGDRDQRVLISRSFNLLRKIASLRDKFDILENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWJ6</accession>
    <name>A0A914AWJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068077.1">
        <property type="nucleotide sequence ID" value="XM_038212149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068078.1">
        <property type="nucleotide sequence ID" value="XM_038212150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212149.1">
        <property type="protein sequence ID" value="XP_038068077.1"/>
        <property type="gene ID" value="LOC119737659"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212150.1">
        <property type="protein sequence ID" value="XP_038068078.1"/>
        <property type="gene ID" value="LOC119737659"/>
    </dbReference>
    <dbReference type="GeneID" id="119737659"/>
    <dbReference type="OMA" id="CFAYDIV"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000002">
        <property type="entry name" value="cytochrome c oxidase subunit 5A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="16843" checksum="A0050A6A8B4207BF" modified="2023-02-22" version="1">MYRRVISSVVSKTRTVISLQACSRPVVASRSYSSKKEETDEQFDARWEAYFNRPEIDDWELRRGLNELHGHDLVPEPKIVAAALKACRRLNDSAMAVRVLEAVKDKAGSHKNIYPYMVQELRPTLDELSINTPEELGLDKPLEDKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX01</accession>
    <name>A0A914AX01_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067785.1">
        <property type="nucleotide sequence ID" value="XM_038211857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067786.1">
        <property type="nucleotide sequence ID" value="XM_038211858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211857.1">
        <property type="protein sequence ID" value="XP_038067785.1"/>
        <property type="gene ID" value="LOC119737469"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211858.1">
        <property type="protein sequence ID" value="XP_038067786.1"/>
        <property type="gene ID" value="LOC119737469"/>
    </dbReference>
    <dbReference type="GeneID" id="119737469"/>
    <dbReference type="OMA" id="TLFHVRN"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="146"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="302"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="626" mass="71105" checksum="0A79388579048B96" modified="2023-02-22" version="1">MPHERVSRGSGYQGARSPSPNQRQAYTLSSNSRAARTPSPNRRKSARSPSPTRKAANSSKSQVHRSEAMSFSTTRNGVHSPTQIRKAERSKSPARNGFHSLPARKPKSKGPYTLERFAMMNFSVKPAKRPTVATKSGSNTGSIWQHTTEPIQKPLLQHLLRDQQLSSRACSAFKAIMKYMGDYPTKKTNLQGTQMTDKIFTDALRLDGLKDEIYCQIIKQLTNNTLNVSEERGWELMWLATGLFSPSDTLQPELGKFLRLAHHTLAEDCQRRLLAVSQLTQQRKYPPHWVEVETIQHHYTQIFHFIFLPDDKSNASFQVSSTMTVGDLCKSIANRLGLKSNKGFGLFLIMASRIIAMHEESDFFFDALRRQIDWEQEGIKSAKSEESDMPVLAYQMFFLRKIWTDVVPGDDVQADTVFHYHQELPKFLRGYYSCPPEDAAKLAALQFRARYGNDKTEMQNIAKRLSDFLPEDLVKSRSVDDWKRAIISAYNQPWITSMTKDAAKVAFLKIMYRWPTFGSSFFEAAKVTGSDNTEDVLLAINKHGILIIDAQSKEVQKTFPYSEIQGWAGSGQSDFFLTVGNESKGAMKLHFKTKLGYKMDDLLTSYVRYMQKRPSSGQHSNNNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXR7</accession>
    <name>A0A914AXR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068492.1">
        <property type="nucleotide sequence ID" value="XM_038212564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212564.1">
        <property type="protein sequence ID" value="XP_038068492.1"/>
        <property type="gene ID" value="LOC119737913"/>
    </dbReference>
    <dbReference type="GeneID" id="119737913"/>
    <dbReference type="OMA" id="YTTHHAS"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49156" checksum="38241B7F649DC4B8" modified="2023-02-22" version="1">MANCSDPNASIVPDNSCDTGIFEFALFFIAAVFVFGVPGNCLILRVYWTKARKTSTHVLIMALAWADLSVCLLQSVYIAELALECGGNGTHLIFLLIGTFETIGIAISLGITAVIAVDRYDCICRPQRRFCTPRRAKVAVFVVVLISVIGNIPEGINDFLLCPYRLLGIGLLVPIFQTIAVLIALIAIVLCYGKVYARILKHVRVGAIPERTLTQDDRAASKIDKDRTIPSTQCALPRKDQLSAIHSKCSTQLIPEALARLEANTSVVDNEVSTVINLASTSYTTHHASTSRLDILEVPQNTNDKMVNLAERDSKVGQKSVSQLSEQGCSNGGDMNHHEATPDTVRRHAPKRMGGAVLQRKTTKMLFVTSVVLLLTWLPVLIYNAIEIAYLTDSNIDTKSAFLTQAILDWLFCIIYANSAINPLIYGLANKRFRKDCTEVFRKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ60</accession>
    <name>A0A914AZ60_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069440.1">
        <property type="nucleotide sequence ID" value="XM_038213512.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069441.1">
        <property type="nucleotide sequence ID" value="XM_038213513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213512.1">
        <property type="protein sequence ID" value="XP_038069440.1"/>
        <property type="gene ID" value="LOC119738606"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213513.1">
        <property type="protein sequence ID" value="XP_038069441.1"/>
        <property type="gene ID" value="LOC119738606"/>
    </dbReference>
    <dbReference type="GeneID" id="119738606"/>
    <dbReference type="OMA" id="RNMDISH"/>
    <dbReference type="OrthoDB" id="10563264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324106" evidence="2">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="23383" checksum="B0754BFE0D3146C3" modified="2023-02-22" version="1">MIGKVLLACLLCGVLATCSGSSSSSSTSSSSSASRGPRSLERLLRRSVAIASSLHKLRSARVRRWESSSPIWKRLHRIQQRAMDFSGMPDLSLIPDAVQVARAFDETHKLVNKDLNDIKLGWQDKPFDLPGLPPQPAAAGWDEEPSDDWGPVVYPGLPDNHEDDWGEFLEPCSDDIVGNACTHNSDCPGCGAFHCSSSTNRCVAGAEPDPNFGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ89</accession>
    <name>A0A914AZ89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069017.1">
        <property type="nucleotide sequence ID" value="XM_038213089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213089.1">
        <property type="protein sequence ID" value="XP_038069017.1"/>
        <property type="gene ID" value="LOC119738260"/>
    </dbReference>
    <dbReference type="GeneID" id="119738260"/>
    <dbReference type="OMA" id="WNEEESC"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="26295" checksum="FF069455B69293A6" modified="2023-02-22" version="1">MAEGILSAEEFARNILEFFQVSDLLKDGWELRYEEKHAQQSCPYLVKRNVLRALHIADVGDAGRLDEHSRTEGAGMDATLRNMEEEEGEGGDGDEDVDVAMPDGRAVVAACRFDYHIVYNLSYSVPTLYFSACHQDGKILSLDEVWQSVPSHYQRRLQSERWTFITQQEHPILGRPFYCLHPCHTADLMTAVLKATSQTSTSHSNYLVTWLSSVGPVVGLALPLEYAKLCEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZD3</accession>
    <name>A0A914AZD3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038069061.1">
        <property type="nucleotide sequence ID" value="XM_038213133.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069062.1">
        <property type="nucleotide sequence ID" value="XM_038213134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213133.1">
        <property type="protein sequence ID" value="XP_038069061.1"/>
        <property type="gene ID" value="LOC119738292"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213134.1">
        <property type="protein sequence ID" value="XP_038069062.1"/>
        <property type="gene ID" value="LOC119738292"/>
    </dbReference>
    <dbReference type="GeneID" id="119738292"/>
    <dbReference type="CTD" id="29925"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000018">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="249"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="359" mass="39704" checksum="FA44C17C597EF9C1" modified="2023-02-22" version="1">MKALILVGGYGTRLRPLTLSRPKPLVEFCNKPMLLHQVEALSAVGVKEIVLAVSYRAELLEQELKEQAKRLGVKITTSHEVEPLGTAGPLALARDILKEDGEPFFVLNSDISCEFPFQEMIDFHKKHGKEGTIVVTKVEEPSKYGVVVYNELGEIQRFVEKPQVFVSNKINAGMYIFNSGILDRIELRPTSIEREVFPQMALDGQLYAMNLQGFWMDVGQPKDFLTGMGMYLNSLKQKNSNTLHSGEGIVGNVLVDPSAKIGANCRIGPNVVIGPDVTIEDGVCIKRSTVLRGTNIKSHAWIDSCLIGWACVVGQWVRMENVCVLGEDVIVKDELYINGGRILPHKSIGTSVTEPQIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0B3</accession>
    <name>A0A914B0B3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069214.1">
        <property type="nucleotide sequence ID" value="XM_038213286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0B3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213286.1">
        <property type="protein sequence ID" value="XP_038069214.1"/>
        <property type="gene ID" value="LOC119738399"/>
    </dbReference>
    <dbReference type="GeneID" id="119738399"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="579"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="788" mass="87341" checksum="0AA392799902BC31" modified="2023-02-22" version="1">MSSESESESERNDVESPPSLGLSSEPKTDQAPKSNPAVNKTKVTQRNLQYNRRKWGKLKDTAKKWIDNQGSTVAPFVIMRLNKGVFEWGGPSFMRGFAEDLEVIVKFKEAAFMRPVPFRHKGTETKKAANSWTGVNVDGVDLQSLPVASLRRILTEICNPKGLCGFWQNPGNKPSWWPSDEVPFQSPNWVSGGGTKLRCHQLLQVLEAYKSSDGTNQQCPGPSGQKDQPRPTCSSKKPPPAPPRPSVTDRVLHKFKKRDYRSCLTTLEALSWADLQVVCNDLMPHVIDKKEQINTNISLADFPASKVDERRSKLARLPKNFAALYSTGDGDCLFHSLSVLVNGTEEATLFIRLAATVYGVCHASHYVSMYLEECGSIQAACAFMHMMCAHPPPGTSIADWTVEEIICHTVQDQAASTAKIQSYSGILQVLFAAGFLGVYIQQYSEDRAPGYDTLLNPCACEEQDGLPLLHVMWVKASSSGAMNHFVPLVPRRAQSRRAAHKGKKFNLGDVAENFCTACLGAMNMCQADVHYLDTWIECDECHKWYHCLCTGVAHAAAENMTFVCCSLNCSTSVAKLDGTTITVGDINRLRNGEDLSGDAIDFFMRHFMKTSNGADALILPYFIGQLLQPNSWLQKLPLSQAVPRMEQHLRTVGITAPRIQQTGNLLLPVCTRNHWVGVIVQREAKSLLILDSLDGFLGADVYNSLHRFVCRYLDLIAHCAADKALNEEPLCMEAPKVKQQDNMHDCGVFLLANFEAFLNGGIDELGKICTNGMKMRRRLITLVHGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B209</accession>
    <name>A0A914B209_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069536.1">
        <property type="nucleotide sequence ID" value="XM_038213608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B209"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213608.1">
        <property type="protein sequence ID" value="XP_038069536.1"/>
        <property type="gene ID" value="LOC119738686"/>
    </dbReference>
    <dbReference type="GeneID" id="119738686"/>
    <dbReference type="CTD" id="2067"/>
    <dbReference type="OMA" id="IPWEFGD"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="10">
        <location>
            <begin position="202"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="426" mass="46196" checksum="3276AC0A313C06C4" modified="2023-02-22" version="1">MGDKQGEEDGKQQEKRLFTIPSAKDIARLEHGKSKVKSYFKSQFGKKPTTAQSKDQATSSNRTNASSSSASTLRNQPNSKVASTSSDSRIPNVTSTATVERTSRTVGDAGTNGRTSGLSTASDLKVGASSAYPGTEPSTCGMPDGAGVGTKRKIGSAFADKFSALREGADYEEPQLKRAAVSTAVVAAPIATSAKAPSGANTIVVNTRQKGNPILKHIRNIPWEFGDIVPDYVMGRTACALYLSLRYHHLNPNYIHDRLKDLGHQYELRVLLVQVDVKDPHHSVKELARMALLADCTLILAWSAEEAGRYLETYKSYENKSADALKEKIETDYLSKVTDVLSTVRSVNKTDVVTLVSTFGTFDKILAASKEDLYLCPGFGPQKAQRLYDVLHEPFLKTTRIERKTATKDTAAATTKAEVPATSEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B294</accession>
    <name>A0A914B294_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070132.1">
        <property type="nucleotide sequence ID" value="XM_038214204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B294"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214204.1">
        <property type="protein sequence ID" value="XP_038070132.1"/>
        <property type="gene ID" value="LOC119739319"/>
    </dbReference>
    <dbReference type="GeneID" id="119739319"/>
    <dbReference type="OMA" id="RSNCESH"/>
    <dbReference type="OrthoDB" id="8742770at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059121">
        <property type="entry name" value="CCHC_ZFPM2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039746">
        <property type="entry name" value="FOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034731">
        <property type="entry name" value="Znf_CCHC_FOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958">
        <property type="entry name" value="FRIEND OF GATA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN USH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25445">
        <property type="entry name" value="CCHC_ZFPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51810">
        <property type="entry name" value="ZF_CCHC_FOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="750"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="706"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="800"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="891"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="974"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="845"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1166" mass="127476" checksum="3A6676522E83A461" modified="2023-02-22" version="1">MMSVIKREAQSRDSTPPLPPQETATPTSEESPPPAPSQAPPRREVPVPSFVQLPDGGLFAESGVPAGTIFGPYKGSIRKAPLRRSEDGEQTAEPIGLKFCDPAGQAYTVEVDRMECEQPWWACIKHAAEHHQANITLFSHNGVLYLRTLEQIPEGKELVMDLTTPKDQGDTSEGDSTDVTNHSPNTAHRPHPAANLVIEGPPFKCNFCCIEFRNPGNLDAHRVYYCPGTATKLLPCSRRRLIAPTTQAEAAPDTSVVKTTPLRTTKTPDVPVVKKIITVETPKTFVCQLCQSSFESRSNCESHMLLLHCDESANLCKFCNFISGDRKGLCQHVFSHVKGTRQETTATLPGENSDPGLDSTSKTVNEVMVDEGDEKENRYTRKFQTNGTQPASSPGAGHIPGSPRSQEDKFISKLPSPEMTAPLSREEIRSPAKLIKTESPNGINVHSVAVGLNREPAQDDILTCAQCDFATSRESVLLKHVTHHNHLQRKTHDGSADAQVPKMDTPDHLDTTCHQCNIVFMSKKNYAAHKQYYCASRHADSTSPPAVPEWDDKTGKASTQGNNNNTRVVTLDKKDGSITRKTLNGSDRHREPCPLKVVSPRCSPYVISRTSVDSSPRNGTQHSTSHSSETSPAPLASPNSRSSPDKPGFDRPLHMIRLDGKPQFLPPGAVLPGQQLVLVTPIVIPQGLGTATKLASNLKIPVVRPSRTEQPLDLSTKPKTPPLSDSSDTGGHKSTVITSELLSQTTSTQLRERQSNRCEECEISFSKKESLLVHKQFYCASRHMYSPRSLVRTKPYDTSKLQTFSNSQPQSKSPSPVHLAKQSPNSNHGAGYIETRNSQTKANISAHVSSSPAFSSSSTGGSNDITSSPNTNPTVSTTASMILLNGNSTHERTDSAKVHNPSPSWCRTQTPKRSASAQSIEWDRERCLPPIKRKKNLIPQPDEDFRRLTTATTNNGSLMTNGVIIKQEPKSTDCVTASEGCSNGKSKTVANSEPTQQHSRNVSRTSTPSPVPHKTTQTIIQKAIMVKQEPLGDIPTSNGYSRESQDTILKSYPSSASLHHQQSTSRTADSPDLSPRPPHIRHPITTPTPLTIPIFRHSSPRLATPSRHMTVSSYLNTGTSRPLLRGVKPTVKHCRNCNISFSSLSTFIAHKKYYCASHHQTKNAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2J5</accession>
    <name>A0A914B2J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070133.1">
        <property type="nucleotide sequence ID" value="XM_038214205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214205.1">
        <property type="protein sequence ID" value="XP_038070133.1"/>
        <property type="gene ID" value="LOC119739320"/>
    </dbReference>
    <dbReference type="GeneID" id="119739320"/>
    <dbReference type="CTD" id="161424"/>
    <dbReference type="OMA" id="HHLVRNF"/>
    <dbReference type="OrthoDB" id="9987665at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81987" checksum="70024459F0CEA21D" modified="2023-02-22" version="1">MAAPTHMSRFPARKNMFKKKIHQAKDKGVKDDTHDGRVGRLDEHTMGYYRRVADTIKDAFQDEAEQGLFLDNVFDQMEGEQVQLCRNQTVSRILEELLCLARPSHLRRFLSGILGEFEVVVRDRFAGHVVQKALLQTAKSLDDGEEGAELQEKVLSMADLLLADLNAVMMDTYGNHILRTMLQVLGGVRVPDQVARSRLSREQQDKETSKETKQLLKKVPEKMQLSLKKITNTLLSAENFNEYLLHRTSGPVLEVLLLVLQQSHPALCHRVGQAILKKSKVMSKNPAQPDKRVPVVFTDSVGSHLFEVVIEVVSSEAFSEVYSQCFGNYLLEMALHPVANFVLQKLIKRSAREEEFSEMFDKLSANLEAILGVNHMGVVLRLAESCVHHPTKQRAFLQGLLSAFHCWEPRERQSSCVLLIAGMVTHEVFFPGSKEDEEQDTKLKPGLTEVNLHGSLLLQQLLKFHHCGPVIAGFMALRDDDLTTVACSPSGSYLLEAFVTSSVVSEKKKDRFVAQLTTNCFKIACHKTGSRSIEAIFKAASLKTKTALVQVLSEKDKQLQSDHFGKFVYRNCAVGLYKLRPQDWEELQGRESKKRKLFAEIIGEGEDRASKKKRRQLEGDAGQPLSSYSDEMLALGMTVKEKEIGESDEDDDIDDIFGKISKPAVKPSVSPQNKSSKRRRSASTHDEKDKPDTGHGQSSDKEEKTHSKARKSKKKLHKKEREKICPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3W1</accession>
    <name>A0A914B3W1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070717.1">
        <property type="nucleotide sequence ID" value="XM_038214789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3W1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214789.1">
        <property type="protein sequence ID" value="XP_038070717.1"/>
        <property type="gene ID" value="LOC119739745"/>
    </dbReference>
    <dbReference type="GeneID" id="119739745"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF59">
        <property type="entry name" value="CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037678978" description="ZP domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="7">
        <location>
            <begin position="435"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="778" mass="84937" checksum="A389612361C48636" modified="2023-02-22" version="1">MARGFGSLVFLLWGVQAFLTDTVESSHFRGEALSWRATDEPNKIDINWMVGFSQSQCDESHITDGTLIVAAENLKCQQCSQQQISTVDYQCTDYSQAENWQRGVGHTRFTIEPGLTEFDIRYATCCWISLHNGGSNAYSAEAHVDLSPHNGVINSSPVTSWMPVSRIQQGCSVTLNIPKGDPDGDVVRCRWPSIEAERGGVTPMPGALLDSNTCIVSINAVSSSLGWYAIALVIEDFSTPTAVISKSKVPLQFLVNVYSSSDACNDKPALINPSPDQGARFGLVPGQVFRTQIRARASSAQIIEIETTSPVGMTTSAISLVPSTMNEHFITASWTPSNNQTGLHVFCFNALDSDGYTSEVRCVYLTVRGWTSAQSPMAATSAASEGTTPQYTHSTALLGEVLTSQLSTQRTTQSTSMTVRPPVMMTQPPPSPSMDCSDSGMTVFIPRSMIGEALASHLHFLDSACVGSHHNATHVKIATTYDRCGTLMEVRENNVMFSNIIHDEAVPVPGSVITRDQDVKIPVQCIMDSEGIAELSFRPDISKITFREDGYGTFNFSLRLYHSNNYARPYQSVDYPVHVGMGNKLYFEARTWSEPGLQLFVQTCRATPTTNPDDFHGYTFIQDGCIRDNTVALHPSLHPDIERFDIDAFAFVGSLPKPVVYVHCDMLLCNSSDAGSRCAIGCQNGTSGSPLSLRRRHARSASGSRSYAITQGPISVEQDEGKEATSKMASVQLPVLLTTVCLLVGCVLVLGALVAVMRKRTKRLHMYEPVSTEDQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5D4</accession>
    <name>A0A914B5D4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070691.1">
        <property type="nucleotide sequence ID" value="XM_038214763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5D4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214763.1">
        <property type="protein sequence ID" value="XP_038070691.1"/>
        <property type="gene ID" value="LOC119739728"/>
    </dbReference>
    <dbReference type="GeneID" id="119739728"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="36801" checksum="6ABCF28CBEF9950D" modified="2023-02-22" version="1">MSFAEQIQAMMPDLVNGKTHQPVEEKLAALDRKLGSHVVNGIKFPASVQPSNLEALKTFEVRDDDVYVFTYPRSGTHWLGEIMQYILHDGKGDYDRTFMTNGLEFTITDDPIQLEGVTPGYKTYAAMASPRCIVSHCLESFLPPQIFTKHGKVIYVARNPKDVLVSEYNLLGAEQLDFDEMFFGFVQGKVVLGCWFDHVLSYWNHRDKENFLFIKYEDLHKDLRGSICKLAKHVGKDLPDDVIDDIVERVTFGGMQKTYQQIEEEHGEEGKLMTRFLGVTPYLRKGKVGNWKNTFTVAQSALFDKIYALRMKGTGLDFDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5J6</accession>
    <name>A0A914B5J6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071516.1">
        <property type="nucleotide sequence ID" value="XM_038215588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215588.1">
        <property type="protein sequence ID" value="XP_038071516.1"/>
        <property type="gene ID" value="LOC119740324"/>
    </dbReference>
    <dbReference type="GeneID" id="119740324"/>
    <dbReference type="OMA" id="FKQVCSM"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="144" mass="16081" checksum="DDEAF7DA8A44926D" modified="2023-02-22" version="1">MAELTGATPDEDIFDSIVMAEERFHEEGFSEGFAAGKIAGDQEGFKMGQVKGRQIGSEYGFYLGFVATWLQLVKEDPGLAKKNVVKTLDALNAMLASFKVNDINNESYWDDLKKIRDKFKQVASLLGVKLDFTDEKTQQPPMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6A5</accession>
    <name>A0A914B6A5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071330.1">
        <property type="nucleotide sequence ID" value="XM_038215402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6A5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215402.1">
        <property type="protein sequence ID" value="XP_038071330.1"/>
        <property type="gene ID" value="LOC119740183"/>
    </dbReference>
    <dbReference type="GeneID" id="119740183"/>
    <dbReference type="CTD" id="10660"/>
    <dbReference type="OMA" id="PINLMQH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF8">
        <property type="entry name" value="LADYBIRD EARLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="176"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="178"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="408" mass="44086" checksum="979C93AC9DACE953" modified="2023-02-22" version="1">MALAPALGSHGGVYIPYQRVSTVRLQLQPVHPRSNPRPYTSFFIKDILGSKIGGVERDSGDATTPCPRPTSPSSGSPWSVPATAAAAATAAAPGASQPSPPGKDANFPVRDAEKTLPSPSCGIIKKDANGSPLSALEELANKTFTGLETSILRAAEAATVNGKRDPLHLFNRQPPRKKRKSRTAFNNQQIFELERRFLYQKYLTPADRDEIASVLGLSNAQVITWFQNRRAKLKRDMEELTMDVTATSKKCTDLNIAADDTAALAASAAAATKTSPCFKEEDGDEDDDEEDRLSTVSEQQQCREQFSLRLASADDNSLHHRRHHHQHLHQHHRHMNLNAGDTPNGQESGESNEPVNIEAVSPGDNGGLEAGSCFAANNAVHGTEGEEEESMDCSTSPSSGFHSDSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6S6</accession>
    <name>A0A914B6S6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071664.1">
        <property type="nucleotide sequence ID" value="XM_038215736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6S6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215736.1">
        <property type="protein sequence ID" value="XP_038071664.1"/>
        <property type="gene ID" value="LOC119740428"/>
    </dbReference>
    <dbReference type="GeneID" id="119740428"/>
    <dbReference type="OMA" id="REDGNCK"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="35702" checksum="309C581748D886C8" modified="2023-02-22" version="1">MSTVLLANLKPHCFGLSLAYIPQLVLLLVAFPERFSLMFGLAGMGGSLGMMVCPPIVDLLTMTYGWRGAMLIMAAASFNVTAFGAMQRLPSSGYEKLKKEDIESLSDDRPRDIRSKLSAFASALVQWLSMHLCIEHPKVLLHLTAWPLLGAIFAAWMVFLVPHAIARGIPSFEAAFLSTFVGGIGHLLGRAIHPFILDRKLMSAFWMFVILNLVNTVSFFLDYAAADNCLALMLLASINGAAEGIVNWIIPSVSKELYEESGYVMDICIIGTCLFGAGEILGGFLAGALYDMTQSYSASFFSLGFMAAVTTTMCLIDRLASKCFNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6Y3</accession>
    <name>A0A914B6Y3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071888.1">
        <property type="nucleotide sequence ID" value="XM_038215960.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215960.1">
        <property type="protein sequence ID" value="XP_038071888.1"/>
        <property type="gene ID" value="LOC119740602"/>
    </dbReference>
    <dbReference type="GeneID" id="119740602"/>
    <dbReference type="OMA" id="PTLITTC"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037595619" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="344"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="672"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="838"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="920"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="957"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="967"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1285" mass="135799" checksum="FC1F9DD6E3B170CA" modified="2023-02-22" version="1">MVTSAIRRRWCLCVMAVLCVYSGTTYGQAPPTFDESPCVEDIYIAAEDKSSVAGIAWIVPLAKDNSGQRAAVTCDKELISGQFNPGSNVVTCTAVDTRETSLTTQCSFEVHVLPKFEVGCPAPIIQNDTTVDFTIPRAVGSGGKMAEVTCNKNSGDSFTAGKTTVTCTATDAEKNLQAECSFDVTVGIPPTFDSNCTDFNVQPTAGKNEAEGVTLPTLTATQANGVTVTAVCRQADSETTFVGGETVVTCTAADTTEPTLITTCNYTVRVYPIFTTGCPGDIIQANGSTVDFPMPIAMDSAELAPNVICDNPVDGFDPGPTTVTCSAEDSEQTGQNVSCSFKVTIGDAPIFNPDPDCTQDVVVSPNSNTQARNVEWPERTANQSDGTAAMVECTPASGTDFEGGDTNVTCVAKDTAEETLITTCNFRVRVYPKFVELCPQIVPRTPDADDYRATIAHLDPIAEDQDGNNVVVTCEPPWGSKFDSKNDSVRCTAEQTPNETASCVTTVLLIPSLEVSTLVRDIDKGPDPGMQTAKVEWDLPSAIVPQPPPADVTCAPASGSTFQPGESDAKCVASWTLPGSGSVAEAVNKFKVRVFPIITCPADVVAAPNTTSPITTVDYPTATATDSTQSDVSVDCVPVSGSQFDNDAATNVTCNATDSVTGNEATCTFLVTVGEAPTFEDNPCHEQVNVPPDTEDGTASSVSWVDPTAMDRDNNTAAVTCTPASGTMDFRAGPTEVKCTAVDSTMDSLISTCIFNVFVSPTFNVSCPGDIVVSPSEAVVSPDWLQARGNMDTTGEFASVQCNMEAGAKLNETVTMITCTATDAGTDFTTNCSFNVTVDSSPPIMTCPADTTLMPDPGTNTANHTWMVNVTDDNTPTENISVLCIPESRSVFKYGSTEVFCFAVDSFGNMGTCTFDVNVTGAACQENCGENSVCTVNPDGESVCTCNEGFSGNPCKDIDECKVDKPCHADADCNNLPPPDFFKCKCKEGFYGDGVYSCEPYIAPEYPNITGSTDLEKKFSVVLAISTSSSYACDPESDKMSFQCLGLVNTLKTSVESLYRKVSPRSFKAVTVDQTAIKKGSVVIPHTVTYNYDYVEVRGIGPTEFLRKSTLGDALQAGAIGTLELVTNCADCSDPKDITDVCANADKDSITCTGNREPYEDKSDDHCILACVSRCISDPKYCNGGVCSQALDKDPLCGSCPANTGGPRCEPLEEEGPNIPLIVGLSVGLGGGALLIIVIGVIVFVYKKKTGKNSVSEFQEDNSRGDGVEALALENREYENQPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B778</accession>
    <name>A0A914B778_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071302.1">
        <property type="nucleotide sequence ID" value="XM_038215374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B778"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215374.1">
        <property type="protein sequence ID" value="XP_038071302.1"/>
        <property type="gene ID" value="LOC119740161"/>
    </dbReference>
    <dbReference type="GeneID" id="119740161"/>
    <dbReference type="OMA" id="SRSANGW"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="406" mass="44981" checksum="3BB034F745276130" modified="2023-02-22" version="1">MLRGIRRTVSSRSGDTMSSHAAVCEDTVAGSCCSPRLVRWLRGSLPVLLWTGYLLVGAAIFQAVEYPEAERQREIQANLTKTTNSTIVRLFTELLDNMNETMNDTKQNKILTELAINLKTMSDETVNITRWDFMNSALFCMTVVSTIGYGFLAPNTQLGRGLCIIYALIGIPLNIIVMASAGRALARYTRSVNRSLRQTWTRCAFWKKRVGPKMESSAPPRTRSKGEGTNDQRRRTHLRTLSLNREEFSDWSNRTSGEQTTTERDGDDDDRGLGVTGSPEPWNGDAPMDAISDTSSPAWLFLFLVLLYTCFFSAVMVITQPGWTVLDGFYYIIITITTIGFGDLQTSSNSDENTSLAYYLFGCLAIVIPVLGMILLSAGISIVVNQFGKKTKAIEEVVCGSSKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7P3</accession>
    <name>A0A914B7P3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071825.1">
        <property type="nucleotide sequence ID" value="XM_038215897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7P3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215897.1">
        <property type="protein sequence ID" value="XP_038071825.1"/>
        <property type="gene ID" value="LOC119740548"/>
    </dbReference>
    <dbReference type="GeneID" id="119740548"/>
    <dbReference type="OMA" id="VIRCIML"/>
    <dbReference type="OrthoDB" id="5967390at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="44972" checksum="B274E78AE550216A" modified="2023-02-22" version="1">MSDATPTGEGLSISSVYDSYTEKQLLAALYGLIFVAGVLGNSSVLLAVVLSRKPRTTTNVFVVNLAVADLITCLSLPIMILAVLSENREKLLVSNNLCSFQGFVLIVCIGCSFNNIASIAVYRAMITRQRNRSRLIWLFNRRCVAAMVAINWLIPFAVGILPVVSEFGSYEYDDKLNTCSFNPTDQGSGTFSIILVAIFYPVQLLATFLSYSFILFTVKNYFRRVNVLSDEPPLAVVGGVMRPPSHSQPGTSQQHHLSGSAREAFSASNQELPLTAPILWGGRHRYLPANRPPSHAAAARQPARARPRFRRNLDVTFSLFLVVFFFILCCTPYSVLIALLEDKSQKYVPFLGALLVSNSCINPVIYTARHPDFKAVIRCIMLCRFPKIPMKSAFLLRLLRFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8T5</accession>
    <name>A0A914B8T5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072243.1">
        <property type="nucleotide sequence ID" value="XM_038216315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072244.1">
        <property type="nucleotide sequence ID" value="XM_038216316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072245.1">
        <property type="nucleotide sequence ID" value="XM_038216317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8T5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216315.1">
        <property type="protein sequence ID" value="XP_038072243.1"/>
        <property type="gene ID" value="LOC119740862"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216316.1">
        <property type="protein sequence ID" value="XP_038072244.1"/>
        <property type="gene ID" value="LOC119740862"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216317.1">
        <property type="protein sequence ID" value="XP_038072245.1"/>
        <property type="gene ID" value="LOC119740862"/>
    </dbReference>
    <dbReference type="GeneID" id="119740862"/>
    <dbReference type="OMA" id="CLYCREN"/>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="36572" checksum="A283AEF0CF12078C" modified="2023-02-22" version="1">MLGLVDCTSWLVFIAYVTLFVNNNLLIAFTKDKDNSYSYSTVLVVLLIELSKLTVATIFYCHKYSFHNLVADLQSNKTAFAYYLIPSVLYSIFNNLVFLNLANYNPTNYAILLQFSIVITGVIYQCLFKKDLSWQQWISLSILTLGCVISHMEEANEVFLELRDVFILIQVLCSSFAGVYNEYLLKNYSSQLDFWLQGIFMYANTSMCCVVLVTISGKLSPGVLTASSLKSVFEPVVILIVVNNVIAGLVTGLFLYKLNSILKKFALAIEMVALAILSRALLGTTVNFTKAVSILLVSVSVIVYSLNPLAIKSEVVVKPGLKLSNGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA54</accession>
    <name>A0A914BA54_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073078.1">
        <property type="nucleotide sequence ID" value="XM_038217150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217150.1">
        <property type="protein sequence ID" value="XP_038073078.1"/>
        <property type="gene ID" value="LOC119741402"/>
    </dbReference>
    <dbReference type="GeneID" id="119741402"/>
    <dbReference type="OMA" id="IWENADE"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037065008" evidence="3">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="21382" checksum="F309B0B3AA668ADC" modified="2023-02-22" version="1">MAANTNLVCILLLSVFGQSIGDRCPGYTDPFGDYVEAFDCPRPDYWADDPDETYCCISSSGTNNFCCDEYSYETFYNDSSGSGWSTTYTVVIVIAVLIAFVVFSLILRAVIRRRSIRQGPAVNVSPPGHYNPYAENDVTYHPPPPPPIPMQSATTSPPPPNAPPANYYEARMDDPPPPYPGYPVPPLGDENGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAA2</accession>
    <name>A0A914BAA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073016.1">
        <property type="nucleotide sequence ID" value="XM_038217088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217088.1">
        <property type="protein sequence ID" value="XP_038073016.1"/>
        <property type="gene ID" value="LOC119741337"/>
    </dbReference>
    <dbReference type="GeneID" id="119741337"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="745" mass="77145" checksum="651475A3CE9E2E75" modified="2023-02-22" version="1">MSHVISPSLTLPSVGEQFTNEVQLNSTVTWPAVTATNSDDQPITCTFSSGDAAVGLTGGVFGVGSHTINCTVINDGGCITSGSFTFNVTVCSLMCLNGGTLDLERCQCGCTQSWTGDTCSSSLSYVLVPTISTQCITAGQAPVSLTWNEVTGNKTSTTAIGVICQDSGDGRNVSVTGGIFGVGSHSVICIAQFSDGSVDTAGFTFNVTLSPSLTLPTVGEQFTNEVQLNSTVTWPAVTATNSDDQPITCTDSSGDAAVSLTGGVFGVGSHTINCTVLNDGGCITSENFTFNVTVCSLMCLNGGTLDLKRCQCGCTQSWTGDTCSSSLSYVLVPTISTQCITAGQAPVSLTWNEVTGNTTSTTAIGVICQDSGDGRNVSVNGGIFGVGSHSVICIAQFSDGSVDTAGFTFNVTLSPSLTLPTVGEQFTNEVQLNSTVTWPAVTATNSDDQPITCTDSSGDAAVGLTGGVFRVGSHTINCTVINDGGCITSENFTFNVTVCSLMCLNGGTLDLERCQCGCTQSWTGDTCSSSPASYVLVPTISTQCITAGQAPVSLTWNEVLATKLSPSLTLPTVGEHFTNDVQLNSTVTWPAVTATNSDDRPITCTNSSGDAAVGLTGGVFRVGSHTINCTVINDGGCITSGSFAFNVTVCSLMCLNGGTLDLERCQCGCTQSWTGDTCSASRNSCTNGWHRVGTMCYKIVYFPSQGDRMTWAQAEAACVADGGHLASLHTQQQQHYIYGEYIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAD2</accession>
    <name>A0A914BAD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CREB-regulated transcription coactivator 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072402.1">
        <property type="nucleotide sequence ID" value="XM_038216474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216474.1">
        <property type="protein sequence ID" value="XP_038072402.1"/>
        <property type="gene ID" value="LOC119740957"/>
    </dbReference>
    <dbReference type="GeneID" id="119740957"/>
    <dbReference type="CTD" id="23373"/>
    <dbReference type="OMA" id="IARETWP"/>
    <dbReference type="OrthoDB" id="8947034at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024785">
        <property type="entry name" value="TORC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024784">
        <property type="entry name" value="TORC_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF15">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12886">
        <property type="entry name" value="TORC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12885">
        <property type="entry name" value="TORC_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity middle" evidence="12">
        <location>
            <begin position="136"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity C-terminal" evidence="13">
        <location>
            <begin position="584"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="73256" checksum="85D04C5BD15FF585" modified="2023-02-22" version="1">MTSPRKFAEKIALHNQKQAEETAAFDQIMKEVSNVSRPTQSHVGHKSHHLQLAPTLGAYRGGSLPNVNQLGNNTIDLQNALHSLEDIKAATGRSPVGDNRVYRSHQRSSSGHRSRHDTAPYQTPYLSPPSDTSWRRTNSDSALHTSVMAPIDPFQGHGSMSPGSHRRAEMVMDHSGNTLKTPLWDTKKMQPRPRSCEVPGINICPSSDQTETEQTSDPIPISNNTGSLPDLTNLHIPSPLPTPLDPEDQQVSGYNHGGVGSPSNLSSSMPSPTHLSTSPTNHTQVVGQHSPQISPQVSPQMTRRPMSSPSSPLGIHATNEHQRRQHHQQQQQQQQQQQQQQQHRQHQQQQQQQQQQQQQQAQQAQQAQQQQQQQQQHQQQQHFIRQGMAVDASAMTLEHQAHHQQYSQQMYTQGQPQVGQATPNLTLDMSKGGLQYRDGTCVVSTSCTSPTSPVSNPQYSPSPAHSPSATSVPQGSPNNKAVSDAYYQQLQHQFEQCSMLAQQEVGSPTHGQQITYNPQDLYTQNLSNHQMSEVDQALFFPQGAFYGQAYMQGLTDTPDLFQPNKPPPAYPHSPFMQSSAGNIPNIILTGGLPDGTGESPPRQDFAKEISNAMAGVDNFDPLFSADSFKLDPLDLDSLQMLTDNDVVADQATEDSFRLDRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBR4</accession>
    <name>A0A914BBR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073673.1">
        <property type="nucleotide sequence ID" value="XM_038217745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217745.1">
        <property type="protein sequence ID" value="XP_038073673.1"/>
        <property type="gene ID" value="LOC119741835"/>
    </dbReference>
    <dbReference type="GeneID" id="119741835"/>
    <dbReference type="OMA" id="AWRIMIT"/>
    <dbReference type="OrthoDB" id="6042169at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF96">
        <property type="entry name" value="WHEY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037183612" description="WAP domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="4">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="367" mass="41290" checksum="8441CEAD6D68CA39" modified="2023-02-22" version="1">MAKIELMLVVVVVAVCAVHAQDDFRKEGLCPEVVLNTTHNFNVSFDCLSDSECSYDHKCCQRPDGAYRCTEPLPNVTSTMRTTTANKFVKPGHCPGPRFTFGRRCPGGQTCSNDGDCYGNMKCCSRFSYDECPSVCRYPDSNTTMSSMRPVSPSFKPSSKPHRDQPGSCPSDYGKYHESYEWYDDVTCKNHCNSTDDCAEGELCCIEEYILEMEHDDYRKRRQADGSRCPVCMKAKLDCDSEYGTTYKHGQLYKRAYDDCYLCQCYYGQTSCYNVCGYDDDDDIWYDGLYMPQAWIAAGVAAGTALLISVIFTLSVCCCLKCCCKDKQQTIVVQQQPPMAQQPGNAYYMSPPREEKLLLADNGYTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCK2</accession>
    <name>A0A914BCK2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073958.1">
        <property type="nucleotide sequence ID" value="XM_038218030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218030.1">
        <property type="protein sequence ID" value="XP_038073958.1"/>
        <property type="gene ID" value="LOC119742022"/>
    </dbReference>
    <dbReference type="GeneID" id="119742022"/>
    <dbReference type="OMA" id="FVSFVQW"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF181">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52810" checksum="960924A54517366A" modified="2023-02-22" version="1">MKKLELITCRKVYSVVILGLLLLAYCFACYHTGLIDTRLVIPQPLARRKNSTDGPPVEDAIRTHVFQIGDTARSLYSDTLGKLPTNPQYHRRWDVNCSAIFAGSERVITSVSKQLLQEQQEQSLMPSDSKVVTWTNDCTLYKKQRGYPTTPNSDEEAGFPLAYILVVHTGAAQVERLLRAIYQPQNVYCLHPDSKSPREFHQAIAGLANCFDNVFIASKLEDVVYAGVTLLLTNINCMKDLTGRSASGHPWRYVMNLCGQDFPLRTNLEIVGQLKAHNGQNEIQSSVPDKRKSRRTEFKFILRNKSIVRTKSRNGPAPHQLKLYSGSAYYAVTRDFVRYILSDPVAIDFLDWTRNTHMPEETYWATLQRAPGVPGGNYRADPQIRPFSVRYVLWYTRASPHKCRGKYIRRVCVFTIGDIHYVQQQPHLFANKFYYDYDPVSLQCLEEALEFRVRHSEESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDI6</accession>
    <name>A0A914BDI6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073910.1">
        <property type="nucleotide sequence ID" value="XM_038217982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217982.1">
        <property type="protein sequence ID" value="XP_038073910.1"/>
        <property type="gene ID" value="LOC119741992"/>
    </dbReference>
    <dbReference type="GeneID" id="119741992"/>
    <dbReference type="OMA" id="IHETSCE"/>
    <dbReference type="OrthoDB" id="5809364at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038166547" evidence="5">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="252"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50768" checksum="0BF016B0DBFFD2E5" modified="2023-02-22" version="1">MAHQRTTWLLLLSALLIISVAEASHASNDSNAYAERRLRQILLRSGEYDAKERPVLLSNKPVDVEVSMAMYALISLDEKEQVLKGASWIIMEWYDYRIHWDPEMYGNLRFLSLGMDDIWTPKILLTNTASEKIENPIQESVFRALASWDGNVTLEGPIIHETSCEMKMSHFPFDRQNCSLVISTQNTPKCIVNLANGPATRIVMNEATSQWQALNFTAETTAQEFQYKAYSKVIFYLVVKRLPYHYLLNIALPSAILTFISLGVFWLTPESGERISMAVSLLLGQAVFWLVTAESLPPTGGEGTPLLLDCIEYNFIVGGLAILLSVVTVGLQHQPGPLRGRFRRKLFLQILPLVVCLQSRGRGKVNDDDSRFDEKDEKLKMTSDMVKIVSLSDKDGRVIQKTKGYSNVDVSRNGLDDMKLVAAILDRLFFLVAAIIFTCGNVKLIACLVHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDJ6</accession>
    <name>A0A914BDJ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073920.1">
        <property type="nucleotide sequence ID" value="XM_038217992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217992.1">
        <property type="protein sequence ID" value="XP_038073920.1"/>
        <property type="gene ID" value="LOC119741998"/>
    </dbReference>
    <dbReference type="GeneID" id="119741998"/>
    <dbReference type="OMA" id="NMTTMPG"/>
    <dbReference type="OrthoDB" id="7493297at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="854" mass="92568" checksum="949FF6E66E10B9F1" modified="2023-02-22" version="1">MIVMVRLWEVVVVAVVYMAAVVPLGITQEGTRNFTPSTELYFSLTTEQPGNITTNVPGNVTTKHGNSTEPYNFTTIEPPSNTTTSQPGNITTNVHVPGNMTTMPGNSTEPPYNFTTVEPPSNMTTSQPGNITTNVPGNMTTMPGNSTKPPFNFTTVEPPSNMTTSQLGNITTNVPGNMTTMPSSSTEPPYNFTTVMTTSQPGNITTNVHVPGNMTTMPGNSTEPPYNFTTVEPPSNMTTSQPGNMTTNVPGNMTTMPGNSTKPPYNFTTVEPPSNMTSQPVNITTNVPGNMTTMPGNSTEPPYNFTTVMTTSQPGNITTNMTTMPSNSTAPPYNFTTVEPPSNMTTSQPGNITTNVPGNMTTMPGNSTEPPYNFTTIEPPSNMTTSQPGNITTNKPGNMTTMPGNSTEPPYNFTTVEPPSNMTTSQPGNITTNVPGNMTTMPGNSTKPPFNFTTVEPSNMTTKQPGNITTNVPGNITTISGNYTEPPLNLTTPTLPGNATDNSTTTELINATSQFPVMPTTAASNLPKDETPKFKGKPKKVIRIEVAISEDSTQCRPAKNNTSSYCQALGKYFFKRAEVYYRNIQGFQTVRLADEMRKGSVIIPHEVVYDYVGMRPQDEGLSAMEVYQRTLAPAVAMGKLGNLNVLINCSDCSEPEDETNFCNFTKNGLASCQNPYLELQCVDGYVKCRSPCKATHADYCNDHGVCSQADNANPTCRCSDSSSEWYHGDRCRYSTSKVGVIGGVSAVLVLFIVLVYAAVYWCKKRSNKRRSWNLLSNENDDEDDYDSEEDVDGFARGPKDPATLSGARSDPPPMMRAVNTPTWRWSTPEQLDIQRCTCRNIQAGNSILACLIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BE52</accession>
    <name>A0A914BE52_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073707.1">
        <property type="nucleotide sequence ID" value="XM_038217779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BE52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217779.1">
        <property type="protein sequence ID" value="XP_038073707.1"/>
        <property type="gene ID" value="LOC119741859"/>
    </dbReference>
    <dbReference type="GeneID" id="119741859"/>
    <dbReference type="OMA" id="DEAFAMH"/>
    <dbReference type="OrthoDB" id="10470293at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="49154" checksum="22E416F3072B5DF5" modified="2023-02-22" version="1">MGEEFTSKGLKDVIMSLEEELAEIKEEPAPGEEAMVDYFGRCEEDDEDDDDDDNDADLDYEPRKKSKRRKLVRKQGRGLRNMTYSHEQRMRMGYYGAKWGIKALKKKFAGVKDSTARDMCNCVMALVVDGILTLDLPLEQQVIPPKMRNGMPVQTGKHTKEKSNVAEPGPSREAAQNKTEEAPSPATGIGGKPKSPADVTMETGDCAFLPKSTKHAGKSPSPALSFQDKVKIGFIAAKDGSCVAVKRFDVSDTTVRECRNVVIRLFESGKLSEIVPLDQQEIPAQESGAAHPVRRGRPPAFAGRFISPIAAKAPLGSSRMITENSPPQTDHTPPTINDHLSERSAPWNPSEVPPSPIPIPIRLSPSPIPGPSPRIDNAQLHRGTRDIFLGSDLAFLRWRNIRMSLGFQNDEAFAMHLMDVHDAFCSTSCRGGGRNEHPHGAEVNNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFJ4</accession>
    <name>A0A914BFJ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Claspin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074212.1">
        <property type="nucleotide sequence ID" value="XM_038218284.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218284.1">
        <property type="protein sequence ID" value="XP_038074212.1"/>
        <property type="gene ID" value="LOC119742386"/>
    </dbReference>
    <dbReference type="GeneID" id="119742386"/>
    <dbReference type="CTD" id="63967"/>
    <dbReference type="OMA" id="LMRYQRE"/>
    <dbReference type="OrthoDB" id="5859781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1343"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1392"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1446"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="162896" checksum="E5D6B668ECB4F088" modified="2023-02-22" version="1">MLGVENSEVQPSQVSPLLLNKDLFDAEDSDSDVDYTARSPSPPLEEVVSQPPDGHGSPLREDGPHQQDDDEKSSVHSDDEEENESATQRQKSPGSKSKGAKSSIAQSRTRRVPKVDAKKIHSESQRIIRESDLSLPYHKPKPLSLNDFFSKKPSKTGVVSVKKLKGLSKRQQIAVFTQQQTDTASNEINGRAALSQPSPKPNKHSRQRSPLSQSSSPTFIEPEADNGKLSSDGNSAVEESRQDISLEEENETPLRLEESSDESGETAAPEVTDMNKDADAETDNTVEKDKVNVSAQEAESLNVTSSKMITSDDGMKEDAGLAQDEEENKEVTQPAVVEVEKDNQKDDTVALVTTAEQDEDADFSLRLSPSQTPTQAPPASQSHRQKLLEASLPKLKTLTPRLSGEAELVIDLGDADSDTEAGFATPCNPGLNRLMERFVKHTARSTPRPRKEVKLSVVSKETGTDGKEDLKLETVAVTIEGEVCEDPSLKVPGAKLVKLKEALQLKMKARREIERQRRKEAYRLDNEDYNEGEEGEMTDKSDTDDESDNDAGGTDLGDGRKEKKIKKNPFVNHEAVDDDDEDYDPEEDSDEYENEDDTDNSDDESDAASNHGNRGQEQKDAPDLQIYSAETDEEDDDEDDEDENIKRVSSVGKAKKKKKLVLDDDDDEEEEEEARGDVARQQETENSPTLELHLDADDEEDEHEEKMNQDDSLSEIPTKNTQLTLDPEMNSPSLTFPRPDSTLLVGRLVTESASSQDGTMDSCDVDKLGESIMRAARSPKKTLTHEEKTRDLFESASNTDGGTTGSSEVDRAGESFTGRTNFSWSAIKKTPGAVQDDSSRELPKQMDNSSNSLDTSFELMGSIIPAHQPGGGLRRNRKTSLEEARDGFKPFSKHHSLLQNAPKSSSKLSELTLPVEDSQDLFRVDTPSLTVAMETQQGGDTQSFRFSYDDDETQTQFLDENGFLKLRSTSKPKPATKRLFEDENASQDQMDELLGLCSGKFNNGAESSSKIRKGLFSQLSSQRVEGTQGNLDELLGLCSGTFVSQKEDSQAKSTLPIHHDADTHSESSFHILSDDEGNHSDRGHRPVLSDDEESKPKKRKRIRVMDDEDSDDDDNDDVGEEDDLAEEEEEVFDSEDELSFVLKQEKQSSKKMVSGKSQEKIRSKVSKDFFDEEAELSGSEYESDEDYDAEDMPDELEQDEADKENVGTEEQLREQVNKVHMKTMEDDDARRLRLYKEMYLPDGDLYSEGKGRARQFRWRHIGDDSQMNLFPGNSDDEGEDEKDEDTQWRMERFKREQWLNEQKEKQPAKEAAVDDDDDVVEENSQFDVFMKTAVNRKRKADPVPAIVDGDKPIPKDKERPINSPKPIKFRHGSFLKRSKGDLAKIASMMKPATNTNAPRVSRNVLYQSITPQADEEDDKKPQLRRSASDSPATQAPKAKRLRLDRSQSLAKPNSIFSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG43</accession>
    <name>A0A914BG43_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED15</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 15 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914BG43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218912.1">
        <property type="protein sequence ID" value="XP_038074840.1"/>
        <property type="gene ID" value="LOC119742743"/>
    </dbReference>
    <dbReference type="OMA" id="GPVPNQM"/>
    <dbReference type="OrthoDB" id="10055322at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048386">
        <property type="entry name" value="Med15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048385">
        <property type="entry name" value="Med15_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019087">
        <property type="entry name" value="Med15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31804:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21539">
        <property type="entry name" value="Med15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21538">
        <property type="entry name" value="Med15_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09606">
        <property type="entry name" value="Med15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 15 N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit central" evidence="12">
        <location>
            <begin position="434"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ARC105/Med15 mediator subunit C-terminal" evidence="13">
        <location>
            <begin position="561"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="677" mass="74010" checksum="D709BBBDA9389FB8" modified="2023-02-22" version="1">MSNMIPTPGIGAVYPGNEDEWKTESFRAKVVAQFDDEVHKTGNPTTKSSIEMENHVFQKAKNRDEYLTLVARLMIHMRGINSRKEGAQGKMQQIGGGGQDPMAALQGLTSITILGARPGQQGTPPPGQQQMTQMMGARQIHGTSASQLTLQQRQKQIQLQLAKQLSGTANSPQPQAAFMAGGPQQGMNSPQVGQQMGSMQPGQQGQMIRGQQPFKQLQSQQMQQQLQQMQGPGGTQHVRGQQGFKAFQQQQQQLQQQQIQQQQLQQQQLQQQQLQQQQLQQQQIQQQQQMQQQRQQQSTQQQRPPASPYGGYSYMSPQAPPMSPFGAGQAFVMSPQGPPTSPYGGQHFLMSPQPMTQQPSPASQPASQGSQPMPSPASYLQPSPSPQQPSPAGSQRGPPSVPSPSGPLNTPGNPGSVGPVPSPGKAQAAGQGYDQQAYAEKRKQMSKYIQPTKKASKEEEFRKDMGGNKTNSLDPNKMSTVPTAPTSMPTASTTVSKSRNICTPLYEAIMLSVKSPTLNHSLQRTFGPGMTAIHGPPTNYPTSTPPAKRQKTESDPQTFTVPNIVQGEVARLASKFKVSLDDAHHLGGSDVHLICKLEDKRLPSVPPIAVTVPHSYPDVSPHWDTSTREYNQTPFLQSVQQTLSSQLKRMPDRFSLTQMLDVWEMCIRKSCLNAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGY0</accession>
    <name>A0A914BGY0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075523.1">
        <property type="nucleotide sequence ID" value="XM_038219595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGY0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219595.1">
        <property type="protein sequence ID" value="XP_038075523.1"/>
        <property type="gene ID" value="LOC119743211"/>
    </dbReference>
    <dbReference type="GeneID" id="119743211"/>
    <dbReference type="OMA" id="LFHITEF"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF224">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="391" mass="44438" checksum="658CDEF87A11FE94" modified="2023-02-22" version="1">MGDGSLPTTEPLLLTTPAVLTGTIEPGDGDEGGGSQPSERFEVPFLFVVFVLGVVGNFFVLVVYSRKRYRRSNAALYILNLALGDMLALTVVLFHITEFFKVTWPTLWRTDLQCKVHRYFRFVAFDLTVFNMVAIAIDRYFAVVHPLRFRLMFTARRTKVICVVIWVLAFMAAIPTPFMFKAIYNNDTSLGTVTYTGKLPFACKVITPFGPWWPEFKSIYLNIVLFYVPTILTAVIYVIIIVTIKRTIRPLKKTTNGRSADAANVSLHQRFNSWKSARTLLVVFVAYVVCYGFFATYNVLFRYAKGLSVPPELYNLALLLPFANSCMNPIIYSFITASFRKACRELLCRRGRRTDRFCRDTASRDDALGQPVVLKLKAMNTDNYSNSVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIZ4</accession>
    <name>A0A914BIZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075806.1">
        <property type="nucleotide sequence ID" value="XM_038219878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219878.1">
        <property type="protein sequence ID" value="XP_038075806.1"/>
        <property type="gene ID" value="LOC119743469"/>
    </dbReference>
    <dbReference type="GeneID" id="119743469"/>
    <dbReference type="OMA" id="VAYKIIM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36271" checksum="AE9A3E1282921AA3" modified="2023-02-22" version="1">MDLLLVVSFVVVSAGLLWMLRKFFEGGWCYSKARLDGKTVLITGANTGLGKETARDLARRGARVIVACRDIAKAEEAVADIRKDTGSDNLVVVKLDLASLASVRECAKKIKAEEPRLNILINNAGIMMCPEWKTEDGFEMQFGVNHLGHFLLTNLLLDLIKSSAPARIVNVSSIGHELFGKMWWDDINMRANYDPMAAYGQSKLANVLFTRELGKRLKGTGVTTYVLHPGNVYTNLIQYMMDGVTFRWRIMAWVMSTPLGRFMTKTPVQGAQTSIYCAVAEELAETTGLYFSDCAPAKASKLAMDDDAARRLWELSAEMVGLEKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKD3</accession>
    <name>A0A914BKD3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075915.1">
        <property type="nucleotide sequence ID" value="XM_038219987.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075916.1">
        <property type="nucleotide sequence ID" value="XM_038219988.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075917.1">
        <property type="nucleotide sequence ID" value="XM_038219989.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219987.1">
        <property type="protein sequence ID" value="XP_038075915.1"/>
        <property type="gene ID" value="LOC119743568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219988.1">
        <property type="protein sequence ID" value="XP_038075916.1"/>
        <property type="gene ID" value="LOC119743568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219989.1">
        <property type="protein sequence ID" value="XP_038075917.1"/>
        <property type="gene ID" value="LOC119743568"/>
    </dbReference>
    <dbReference type="GeneID" id="119743568"/>
    <dbReference type="OMA" id="IKFSLQC"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000029">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF89">
        <property type="entry name" value="NEUREXIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275772" evidence="11">
        <location>
            <begin position="27"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="265"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="457"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="640"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="682"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="866"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1536"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175819" checksum="35838012235862F5" modified="2023-02-22" version="1">MARYFVNGRFCLSCFCLIACVGLTGALYYEGSVDTYTQYERWNTSVNGTLRFQFKSKQTNVLLAYADDMKQVDFMEIAMEDGSLLLHMRINNKGRTLIVGDNVDDGEWHTVEVIRSNPRKFTFKVDGDERSGTMDGEIIELPTQTDFFFGGIPRQVRRSHLARPEARSRTHLKGHIRNIAYLVQARPNRWRRPEQLASNNVREDFSDLCSTNDPCKNGGLCVSEQGRSRCECDGTGFVGEICEEEYTPAPQSQSDEVIDGREQRAITATFDGTSYISYSLALEEVNTLQDDIVFDFRTQLPNGLLLYVGHESDYIYVAMVNGLLEIAINLGSGEYWKSIQPRREMDVFTDNNWHKVRISRTRADVRVRVDGSLLASGSAGGNFGRLTVGNEFYVGGSPNPATLSGSRVGENFRGNLRDVSYYGNIEIDLLEKAYSSDPLIYMLGDILFREETVQGIDPITFLTEESLLRLPRWNAESKGSLSFDFRTNEPSAVIMYSSGSDEMSDFLAFELLEGYLYVILDLGSGPVREKAYTFPLNDGEWHHVVFERDLAIGIINVGSSTSHKFEVPGHNDKLNLEMDLIVGGIEPLQSLPLELFSGALRHGYVGCIRNMAMNGETLDLPQYVEEQSEDGNIVRFCREEDPLCTSDPCQHGGSCREGWNRFICDCRKTGYTGETCKDEVARLAFNGNQSMRITLRETTRSKVEEVFLRFRTSHPDGMLLATTSDTIIDILLAELSHGEVRVTANFGTGSTTITAGTNLDDNMWHSFAIERHDRTLRLTVDNSDKAEAGDDFESGTLDFRYIDIGSLLSRPHLTGSIDRPPNFQGHMEQLIYNNHHYFDLARDEMPDFIENTASFGEQMSRRPIHDPFTFHTPEVIVQLPQIKTYPSLSIFFQFKTTEPDGLIFFTEGELDFLAIELVDGFIYYTFNLGGGAKTLRGNSRERLNDNRWHEVGISHDSRDRQVLKVDSRSMRSRATMEANHFDFTENLYIGGKETFEFLPEKIQATQGYQGCLASLEINGRHEDLMETAVSMELKEELTRGCEDKRELCIDHMCNFGGICVPGFDSYTCDCRRTSFTGQYCSNVSIGYQFGEDGGLISLELPRDQWLRSDRDSLSLGFVAESLDGILTHISSANSHDYIEMKLLSGHLFVRYNFGAEDHVIGEKTYRVSDGRYHTVEFTRRGENSTLQVDYYPKVELFQNYGRKGRASYFDAQSKINIGATSSAFRRKRRAIMYPFQGIISGLAYNDLRVLDMAASGDPRITFDGDVSLVSPYTIWEYVTEPYPTMSLTTANITEKPVQPEFPEPDPSPHVGPNKTLTGPTKMVMSTATTDGDIDFGTDPDNIFVTQSGCGSVDDEDCQMASVTKGDGAIFTPVDEMESTTAPSITTSSPSTAIPTTPTPKMSLPDTVISGSPCSDPDDPGCISGDTTPSTTTDFNYTTFTSKAAPTPPAPKITQKVVPTTHKSTLGSHLPEETKEGDGLGFLGQTWLVIGLVAAGAFIFLFLVIILYKFRNRNEGSYHINESRNYSVSDATRTALLPSQQQPQQPNTNGTLPTKPIKPKLPPEYATKEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM29</accession>
    <name>A0A914BM29_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076527.1">
        <property type="nucleotide sequence ID" value="XM_038220599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM29"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220599.1">
        <property type="protein sequence ID" value="XP_038076527.1"/>
        <property type="gene ID" value="LOC119744592"/>
    </dbReference>
    <dbReference type="GeneID" id="119744592"/>
    <dbReference type="OMA" id="HTHKERP"/>
    <dbReference type="OrthoDB" id="10069902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="170" mass="18946" checksum="13D5D04E2AEDB7FA" modified="2023-02-22" version="1">MSGHGPGLATGMGMFGLPPDAQGLELFDSREDALKIFRKYKEISNRQDSADKFKKTFDPSKPGAMVTFEVTLRSVDRTTIEELGLASSITDWKKFPGILKMMFHKWSVDPTVLTEVMQFVVFIKRMGFTLKVGDPMEDVGLVSMANEEVSFSSLHVHKERPLLVIASSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM38</accession>
    <name>A0A914BM38_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077184.1">
        <property type="nucleotide sequence ID" value="XM_038221256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221256.1">
        <property type="protein sequence ID" value="XP_038077184.1"/>
        <property type="gene ID" value="LOC119745033"/>
    </dbReference>
    <dbReference type="GeneID" id="119745033"/>
    <dbReference type="OrthoDB" id="10002605at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="227" mass="27372" checksum="7F25D1CC97FE1F0C" modified="2023-02-22" version="1">MVKTLKKTSCDVPSTSLRLAPPQGRRLPVFHRQCANQLVHADCVLVLGEQRFQRVPCSHWEGTGASVPFSWINLEKRCTDNMRKHEIKQREYEQKLNRKYDLKLRAYEYNHRAYEFNLRYHIDDTEPRCSDYLVQRRRVSELKMRRINKMTKQRVSNQKALRSLKVSRQTCCSRSQVLESYVEYCQEAKKVSKPNRKKMRRSQRRQAYHRMRNGKMIELRMSKKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMX9</accession>
    <name>A0A914BMX9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077478.1">
        <property type="nucleotide sequence ID" value="XM_038221550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077479.1">
        <property type="nucleotide sequence ID" value="XM_038221551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077482.1">
        <property type="nucleotide sequence ID" value="XM_038221554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221550.1">
        <property type="protein sequence ID" value="XP_038077478.1"/>
        <property type="gene ID" value="LOC119745296"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221551.1">
        <property type="protein sequence ID" value="XP_038077479.1"/>
        <property type="gene ID" value="LOC119745296"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221554.1">
        <property type="protein sequence ID" value="XP_038077482.1"/>
        <property type="gene ID" value="LOC119745296"/>
    </dbReference>
    <dbReference type="GeneID" id="119745296"/>
    <dbReference type="OMA" id="IKKWHEL"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275774" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="302"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="64452" checksum="30E0765C6ED534DC" modified="2023-02-22" version="1">MESSLRILCLLSFLTVFVNFCSCDSPEHGIFNITLNKIDRFSGVSKNLAEDTEIAITVDCNGKGKFAIEWVVRYTECNGLTLENTTHFISNLFEPNGDLGTMFDVEDYIAVQRSDASNELNCETPHLLLQDESGPDSYTCYSTYKNQHCQFRGVLPPTTETPAAAPAAPAAAPAAAPAAPAAVPAAPAAAKPKAPADKGKASRAVKRRDTDGQDADKNPKTVATNPSGTPKPTPKPAAPTKKVNATLSKPLKGRVTRTNKRAGRYWVLVHLKPLGPPDQTLQVTLTITMKSPSGFLSAYQAPLLVFYGVMCGAYSILTFIWLILLAMQWRDLLRIQFWIGGVMLLGLLEKAVFYAEYENINNYGMSVPGAIIVAELISCFKRSSARMLVVIISLGYGISRPRLGKDLHWVLGVGMLYFIMSSVEAYFRVKGTDQSDMIAILPLSVLDSVICWWIFKSLVDTTRTLRLRRNLVKLWLYRHFTNTLIFCVVAAFVFLLWSMRVHRWTDCMKKWNYLWLDDAYWHILFSVFLVVIVILFRPTANNQRYAYSPLTNREGDDKSIESMLIDAFGWDRSDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP06</accession>
    <name>A0A914BP06_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077436.1">
        <property type="nucleotide sequence ID" value="XM_038221508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221508.1">
        <property type="protein sequence ID" value="XP_038077436.1"/>
        <property type="gene ID" value="LOC119745271"/>
    </dbReference>
    <dbReference type="GeneID" id="119745271"/>
    <dbReference type="OMA" id="RDGHHIR"/>
    <dbReference type="OrthoDB" id="5983862at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027867">
        <property type="entry name" value="SPATA48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15073">
        <property type="entry name" value="SPATA48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="448" mass="50885" checksum="CE4B42176E6160DA" modified="2023-02-22" version="1">MVDTAVRPRPMGDLRLHLQTDTNAGPNSIEQVVLNRRQRQMKFPQLRGRWDVDSFQWKSSPNLVKYHDDTLAPLRDNVPVIDPVSGFVSAATDVDRNTGVDRMPSMQQIDNTPNTVTPLSPRPTTTKAHREKEKDRIRGTFVPTKPDTPQFSRARSNPEMRLVKSESDVTHILNDPGTWAGRKISDGFIRAKLGGWTSAVDPREASKEQERIWKQLHERNIKGQMSAVDKSPNWKDEAALRYIYTSAAQRASKDVDWDSKLAPKILPPASTVESQADPVSHCFTDNKRYEPSAAAWQNLGRSWDWFQTRDGHHIRGPIAFCSPHRKNKQIPNYTGCIGGEGEREDHHKFFIPTTVLRSLVPKYTDTARRANIPGYTGCTHWMNTEPANVNVSIPQPQTTARVHRSLPSERNMSPHKRTSRMSRMITLVPPGNPFNTIDKDGRTLEQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP64</accession>
    <name>A0A914BP64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arpin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Arpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078063.1">
        <property type="nucleotide sequence ID" value="XM_038222135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP64"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222135.1">
        <property type="protein sequence ID" value="XP_038078063.1"/>
        <property type="gene ID" value="LOC119745630"/>
    </dbReference>
    <dbReference type="GeneID" id="119745630"/>
    <dbReference type="CTD" id="348110"/>
    <dbReference type="OMA" id="QTVAFWI"/>
    <dbReference type="OrthoDB" id="5953051at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051126">
        <property type="term" value="P:negative regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018889">
        <property type="entry name" value="Arpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31199">
        <property type="entry name" value="ARPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31199:SF1">
        <property type="entry name" value="ARPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10574">
        <property type="entry name" value="UPF0552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="222" mass="24742" checksum="E347DE7B653B55EB" modified="2023-02-22" version="1">MSRLYDNQPLQSVPVENQTWKGEWNPEVHSGPGVLLDGVLHGRSRHVITDTNQKKSRYVVLHVKPTVAHRRKFDSRGIEIEPNFSDTQKVSKGHLMSSYKTEAKGKSDRLSTPEVISTVSKQDLSSLTSKHNRDGCVALWAREEQLDKIELENGDTIRLKTTADCPFIFSIAKLDTVTSQVSNYAGGETVGSSWTDKVMSMKAQDAPEPQDTGGAEDDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPD2</accession>
    <name>A0A914BPD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L34, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078135.1">
        <property type="nucleotide sequence ID" value="XM_038222207.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078136.1">
        <property type="nucleotide sequence ID" value="XM_038222208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078137.1">
        <property type="nucleotide sequence ID" value="XM_038222209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078138.1">
        <property type="nucleotide sequence ID" value="XM_038222210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222207.1">
        <property type="protein sequence ID" value="XP_038078135.1"/>
        <property type="gene ID" value="LOC119745677"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222208.1">
        <property type="protein sequence ID" value="XP_038078136.1"/>
        <property type="gene ID" value="LOC119745677"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222209.1">
        <property type="protein sequence ID" value="XP_038078137.1"/>
        <property type="gene ID" value="LOC119745677"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222210.1">
        <property type="protein sequence ID" value="XP_038078138.1"/>
        <property type="gene ID" value="LOC119745677"/>
    </dbReference>
    <dbReference type="GeneID" id="119745677"/>
    <dbReference type="OMA" id="ASHWWLA"/>
    <dbReference type="OrthoDB" id="10069657at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="141" mass="15722" checksum="2CFCF48AC3AAD097" modified="2023-02-22" version="1">MAATFLAATRIAIGRLFRPATAGGAGGIDNGIRKFNSAFMCLRTAKLPTLTTHRTLTTGPCNTTAPHWWLAAGNQTPRQQLLQHHPTPSLVPCCFKARGNTYQPSNVKRKRKHGFHQRMSSKSGIQLIWRRLLKGRRLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQU7</accession>
    <name>A0A914BQU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078330.1">
        <property type="nucleotide sequence ID" value="XM_038222402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222402.1">
        <property type="protein sequence ID" value="XP_038078330.1"/>
        <property type="gene ID" value="LOC119745794"/>
    </dbReference>
    <dbReference type="GeneID" id="119745794"/>
    <dbReference type="OMA" id="DWFYLAG"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="211"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="444" mass="49379" checksum="887F750E51704B88" modified="2023-02-22" version="1">MAAPKASKNLLFAASFLVSLLVFFLAYLASSSLGFGTLSIKRAGILLGVFVPVIFLISYFLVWRSLVLKPMQNVRGREKGLVLHQLFRTWAAVLFIFLLFAHLSQPCVLFLGKVTEVGTVSYLSFVCFGALFILGTVVLIFEIVEFVLKLTILKGLHWQWFQENWLILRVVVVAVITSVLVAVSLMTAAKGPMIKPLQLPVRKLPLSMNGLRIVQLSDIHLGPTVGRSQLQQAVDMANDLKPDIVVITGDLVDSTVENLVEAVSPLQQLKATHGVFYVTGNHEYYTFDVDHWLSHLKSLGIVCLPNSFVRIVQPDKPQDWFYLAGTNDIEGKRMYDTEHHFDLDKALDGTDSDHAIILLAHQPRAAKQAVQSQYDISLILSGHTHGGQMFPVNIAAYLTNPYFAGIYQPKEGTYVYVSSGTWYNGPPMRLFSRAEITVITLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRB8</accession>
    <name>A0A914BRB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078184.1">
        <property type="nucleotide sequence ID" value="XM_038222256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078185.1">
        <property type="nucleotide sequence ID" value="XM_038222257.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078186.1">
        <property type="nucleotide sequence ID" value="XM_038222258.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078187.1">
        <property type="nucleotide sequence ID" value="XM_038222259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222256.1">
        <property type="protein sequence ID" value="XP_038078184.1"/>
        <property type="gene ID" value="LOC119745714"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222257.1">
        <property type="protein sequence ID" value="XP_038078185.1"/>
        <property type="gene ID" value="LOC119745714"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222258.1">
        <property type="protein sequence ID" value="XP_038078186.1"/>
        <property type="gene ID" value="LOC119745714"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222259.1">
        <property type="protein sequence ID" value="XP_038078187.1"/>
        <property type="gene ID" value="LOC119745714"/>
    </dbReference>
    <dbReference type="GeneID" id="119745714"/>
    <dbReference type="OMA" id="FRPFSCE"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF72">
        <property type="entry name" value="LD32258P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="845"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="969" mass="109513" checksum="1B2A83288AAF718D" modified="2023-02-22" version="1">MASSVVGCRVGACVVARSQLQQLCTASVCVRCLSVVTDPMRNSIKLPKPLPTISRATQAGVHSEILRTNTRKIPSPGNSCQGAVKRFQATVSADALSDEITSTTDPIQVLNLTSRHRSRLTHLHVYQAFNHLWHLAKFHDGPYLACFLEVVRGHPEFDALCVLAENKLKDVDGKLLVDTLYAALRLTPEVHHPFVRELRTEINHRLDEFETDTLSKLVVCLQDMNDNRSPMFCKIVQLFSDKLHKVDSIRELSAWMREVIHLVSPPNRQAIFQKASQLLAEANPADIGDNSLRRVIQTMARSRSISQPLLNQCSQLLLGMIENIPVKESCMVQSMLESLDYENKELREAIRKTIAKKLPDCQDPDELSYAMETIGGVASANIKLLLADKAEEIVSILSPSAISHMSVGLRLMGYRTQNPLVRKLVKRIKAESSNLQVEGIADIVGFLTRVDNLDSEVFTLIQERLLEILRSAFSPSRVLGCVSSLSQLPSLDSLDHIVLERVRAMMPQLHIAGINHMLLATSRIARKLDKSGTPCQDFLNLKQELFERAQVSIDKITSIHYLNNIAEIILQDGGHVLVLDAAMKQSGSILHRLTPQLAVECARILFRARYLQRDLMDRISEVATHKMNKITPMQVLYILSPFCTLNYLPPNAPQFFQACVARCEPFLDSLPSGYLVDLTHILTFLQQFHEPFIRHIFSLDFLTKLDEELETIPDRSMMYRRKLMYLNRTVALECPELQVPWFHEQFSQDLLKKRSLTLDSSLMLIQSALVEVLGGAQYVRSFVVSPYYYDISFECVLDSDGNPLACADYGSVLNRSEAKVAGTMLADLMQWGTQTKQLPHGAQRVAIDFLSSSLFCINSRRTLGMVALKRRHMELMGYRYVQIPHFVWSSQALTEREERTEYLRQLIFSPNEEQEQEQQEQGLDVGSSLGEMLTGRVQPKLPKNLGIQEEGLLEDEMVLKVLNTFDKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRE3</accession>
    <name>A0A914BRE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078862.1">
        <property type="nucleotide sequence ID" value="XM_038222934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078863.1">
        <property type="nucleotide sequence ID" value="XM_038222935.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078864.1">
        <property type="nucleotide sequence ID" value="XM_038222936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222934.1">
        <property type="protein sequence ID" value="XP_038078862.1"/>
        <property type="gene ID" value="LOC119746135"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222935.1">
        <property type="protein sequence ID" value="XP_038078863.1"/>
        <property type="gene ID" value="LOC119746135"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222936.1">
        <property type="protein sequence ID" value="XP_038078864.1"/>
        <property type="gene ID" value="LOC119746135"/>
    </dbReference>
    <dbReference type="GeneID" id="119746135"/>
    <dbReference type="CTD" id="9540"/>
    <dbReference type="OMA" id="WAEVPDP"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275798" description="Enoyl reductase (ER) domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="46"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="374" mass="39687" checksum="487600A4F0D2610F" modified="2023-02-22" version="1">MVDPTVCLIILLSGVLFLQQPLQVSSSLGDTESMATMKAVSFDEPGGPEKLYIAEVKRPEPGQGEVLVKVYASAINRADTLQLGGSYNPPPGASEILGLEAAGEVVQLGPGCSSKWKQGDRVAALVAGGGNAEFVLAHEGHLMPMPSHMTMLEAAGIPEVWLTAYQLLHFVGHVKAGDRVLIHAGGSGVGTAAIQLVRLAGAEAIVTAGTQAKLDMAQELGAVAGFNYKQVDFADKVLEFTQNKGVDLILDCVGGSYGEKNLRVIAMEGTWVLYGLMGGVNVDGPILGGILRKRVTLVGTTLRTRSVEYKTDLVEAFTNNALPHFGTRLKPITDRVFPLEEIVDAHKYMAANKNIGKIVLKVHDEKPGTGHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT13</accession>
    <name>A0A914BT13_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078652.1">
        <property type="nucleotide sequence ID" value="XM_038222724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222724.1">
        <property type="protein sequence ID" value="XP_038078652.1"/>
        <property type="gene ID" value="LOC119745985"/>
    </dbReference>
    <dbReference type="GeneID" id="119745985"/>
    <dbReference type="OMA" id="PWNKMSP"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256:SF1">
        <property type="entry name" value="GEO09626P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14256">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="83" mass="9324" checksum="4B7CA2DCA8148940" modified="2023-02-22" version="1">MQGLTVKSLRSHYALIPLFVSVGIGAAWAAYYIGRLALKNPDATWDKKNNPHPWTKIKPNENIKFYAPGGIEFAKLKSNRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZU0</accession>
    <name>A0A913YZU0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044922.1">
        <property type="nucleotide sequence ID" value="XM_038188994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188994.1">
        <property type="protein sequence ID" value="XP_038044922.1"/>
        <property type="gene ID" value="LOC119719534"/>
    </dbReference>
    <dbReference type="GeneID" id="119719534"/>
    <dbReference type="OMA" id="MWAATIS"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="427"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="566" mass="66030" checksum="AED4DEC58755FACB" modified="2023-02-22" version="1">MAEGVELERVRVVPGSESEGGGPARSDSAVLAAMGVAVKPRSRRRQSIAEAMTKENLFHASTKDFVKRIYRSDKALKNEQLRQQRFRHFVIHPFSNFRWYWDLWMVFLMSITLILLPVNIAFYSNQFSISWTMVNCFTDSFFLIDICLNFLTGIVDHQNENVILMRRRIALRYLRSWFFPDFISSFPFDYIYIFMQGTTDYKASSTSLTLRVFRLAKILGILRLLRLARLMRYVHKLEEILNVEGAVIRIVNLTLVMLVVIHWNGCIQFFIAFAQDFPTDSWVSISDLEHADKWQQYSWSFFKSICHMLGIGFGRHVPQNLIEMWAATISIMLGATFYALFVGQMATLMLSIDASGRIYNEKINQVKEYMRYRKVPSSTQKRVLEYYEHRYQRKYFDEDTILREQNDPIRREITQHRLRSLVRKVDFLNQGSPEFVLDVIEKLTFEVYLSDDVIITAGRLGNVMYFIEHGTVSIEVEGRTVGTLHDGDHFGEIALLIDERRVASVIAKTTCDIYSLNRENFDKVLTEYPNMRKMMAAVAKERLQKIIQSNAESSDDTEEFHMAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z043</accession>
    <name>A0A913Z043_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045193.1">
        <property type="nucleotide sequence ID" value="XM_038189265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z043"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189265.1">
        <property type="protein sequence ID" value="XP_038045193.1"/>
        <property type="gene ID" value="LOC119719777"/>
    </dbReference>
    <dbReference type="GeneID" id="119719777"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="262" mass="28095" checksum="F387AEFFB2D1E35E" modified="2023-02-22" version="1">MSCFLNGRVAIVTGASSGIGAGIARHLAILGCSLVLVGRNEENLRLVQAECVDRGLDEDKILVVKADLGNEKDVKELLKKSIEKFQKVNILVNSAGVLAYGSLEEMTVDQLDSLVAGNLRTLFLVTKHSTPHLAKTKGSIVNISSTSSRRASPGLLGYGMTKAAVDHFTKTVAIELAPKQIRVNAVSPGLTVTPLYKKAAPNWNPTDDNLEEEGKRWHPLGRACTVEDIARCVAFLVSDEASFTTGQIIPVDGGRHVAQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0G6</accession>
    <name>A0A913Z0G6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045404.1">
        <property type="nucleotide sequence ID" value="XM_038189476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189476.1">
        <property type="protein sequence ID" value="XP_038045404.1"/>
        <property type="gene ID" value="LOC119719985"/>
    </dbReference>
    <dbReference type="GeneID" id="119719985"/>
    <dbReference type="CTD" id="3420"/>
    <dbReference type="OMA" id="TAPDIMG"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="377" mass="41304" checksum="E83AF298384035BC" modified="2023-02-22" version="1">MMASSLFCKIMPRGLKLPSCHLVRTLTTSQVCHKPVAPAAQPDTKRTVTLIPGDGVGPELMLSVREVFKNAGVPVDFEELFVSEVQVGKSATIAEVIDSFKRNQVALKGIIHTPWGGGGELQTLNMKIRRELDLFANVVRCRTLPGIQTRHTDLDFVVIREQTEGEYSALEHESVPGVVECLKIITRANSLRIAKFAFDYARRNDRQKVTAVHKANIMKLGDGLFLESCRQISTLYPKIQFEAMIVDNCCMQLVSNPHQFDVLVTPNLYGNIVDNLAAGLVGGAGVVPGESFSSKYAIFEPGARHTFSQAVGRNIANPTAMLLCAANMLKHLHLDSHAKLIQTAVESVLKAGKVRTQDMGGYATTSEFTNAVMNNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z120</accession>
    <name>A0A913Z120_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045362.1">
        <property type="nucleotide sequence ID" value="XM_038189434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z120"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189434.1">
        <property type="protein sequence ID" value="XP_038045362.1"/>
        <property type="gene ID" value="LOC119719920"/>
    </dbReference>
    <dbReference type="GeneID" id="119719920"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="39665" checksum="7A20AB9400959DC4" modified="2023-02-22" version="1">MQSDENIGEHLVGIQRHLRDLGLHLRSIKLHQDEGENMEKQTLCLTARGHKPRRLPGKKRVVSSKKGKNTKSNLQHRNVNFTFVNINLTNSPLHVGSSSENRYCYGSCGSERQDMVLPPQPANDLDVLEESINDFVQSRETTIQLLYSVERDLIEGDLHVRLAKLKVAGRSTELVGTALVIGGFASSFFTFGTSLILVSVGAGLGAASGLTAVGGVLTEFITSKLTSEQAIRTIEQERIACDNLNAALERMNSTVRHELDAHESVGGVGTANIKRGKASGNTTFEAVSASGSSGRGMAIAGATLAAKVATIPVDPHTLIKSAIDIHKKNVPEIAEVIHNIADELQTQLHEKVGEIRANYGTAVELAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2U9</accession>
    <name>A0A913Z2U9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="12"/>
    <dbReference type="RefSeq" id="XP_038045316.1">
        <property type="nucleotide sequence ID" value="XM_038189388.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045318.1">
        <property type="nucleotide sequence ID" value="XM_038189390.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045319.1">
        <property type="nucleotide sequence ID" value="XM_038189391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2U9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189388.1">
        <property type="protein sequence ID" value="XP_038045316.1"/>
        <property type="gene ID" value="LOC119719919"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189390.1">
        <property type="protein sequence ID" value="XP_038045318.1"/>
        <property type="gene ID" value="LOC119719919"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189391.1">
        <property type="protein sequence ID" value="XP_038045319.1"/>
        <property type="gene ID" value="LOC119719919"/>
    </dbReference>
    <dbReference type="GeneID" id="119719919"/>
    <dbReference type="OMA" id="SEQMNAH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000204">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000240">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="37525" checksum="9CDAEB3A716FCA72" modified="2023-02-22" version="1">MDLPMDQGMELGVSNDKYNTLANFSVEKKIGKGQFSEVYKAKCLVDNSIVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIMYQASFIENNELNIVLELADAGDLSKMIKHFKKQKRLIPERTIWKYFVQLCSALAHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHETGYNFKSDIWSIGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDIYSHEMAALDSPFYSEGLDLWTLCEKIDKCEYPSLPSYFSNRLRTLVQVCIQPNPDHRPDIDYVHSKAQENHAASLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z476</accession>
    <name>A0A913Z476_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein very KIND</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045530.1">
        <property type="nucleotide sequence ID" value="XM_038189602.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189602.1">
        <property type="protein sequence ID" value="XP_038045530.1"/>
        <property type="gene ID" value="LOC119720079"/>
    </dbReference>
    <dbReference type="GeneID" id="119720079"/>
    <dbReference type="CTD" id="85442"/>
    <dbReference type="OMA" id="WAGKRMS"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029899">
        <property type="entry name" value="KNDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560:SF0">
        <property type="entry name" value="KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21560">
        <property type="entry name" value="VERY KIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KIND" evidence="7">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="1885"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="2091"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1554"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1630"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1124"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1354"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1376"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1487"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1683"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1701"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1715"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2375" mass="260786" checksum="72CAEBC12E7C55DC" modified="2023-02-22" version="1">MSYLFEPLPTLQEDEELVSLTDILDLRHGCLREAEMWAVCKECVLSLDGFRRASVDQFSKLCLCADTLAFDGGGCVCFIDTDVVDNNFRPPEYSAKRGTTLKGHLYSLARTLLEAAEYCLPDEDEAEISQPLYDLVNQLSLEDPDKRLDVHEIVKTCERNLRDPSTFLCRQLSSISRRRISIDSCYDFPAHDESLLNRRRSSTASQVLFSRRHSLSNGTSWDSLSPSDVFNIPSSASPSPTLLRSLSPNTKTVKMADEKRTRGLDPPEEKPLREAPTAATLNNLSQRAQDILKKIYSTSESQSGAGKVTNGGGRGTSENKRSPVMKRHNSVATMGSSYSGDRLGSKRNSDPVTLGYPLSKTEPDVPAITVSAVHTYGDGTNSDGASTPNSVKVSAALARFLKSHKQQYEEKSDETGTGDQTGLKSEVPGDLRSESGDENSGSTEPLSPLGTEDFSLLEGGMILDDPWLDDEESEAEGPVEFKRTLRSHSIAAFHSFEPRSSAFRLNQNHSSKSNLSSKSSRSSLDNITEEKNPKTNTGTKSMAAKRARRKTESISGTDLSYNSIRDLNKLQDFFANRRSSIADFRAQASLVSSATHFTPIIVSDEKSGSTKSLTRSTSSPNVAEAKAKAKAAMEAIKMDLKAPKKQPPPPNMLESLENDAMASRVPSPSNQTNQSPEKLQEDSNKTDTKNTEQSVLTVEPALFPISKPEIVTKDENASERTTEPQNLQVDKRKFSLEAEAITLKGSSQTDQRNVSRDSASSGETRVQKAKVKVVQGSPISRESAFSPIQKPHRPSLESQTASKPEQIQSIAEVPASSSQPTTVKPIASLQMNNQTLSANQNKASEILANQPQNVPTTQSSAFAAIYQNNLLGQMSPLRLASPQTMHPITNPPVAAVPSMAGSPSGAVIPSFPLKVQLQQDPATGLFHVLPVDIQGSPVVFQGSPVICQASPTISQASPAISQTSPALSQGSLAIQGDSTITPGEVSTVTIQGSQVITSGLAVNKTPATSANKTTAMSNIKTDSRNYWTRLKSPGASSDGESTCIPVTPEMPRKDTAERKREQMKKRHEKPKHFVSPSKRIPARGALNKASESESSESSYLETLRLKSSPKVVRKKPTKTSSSHSDPDRARERNHERSKTHNHDKVGKLDDSKSRSKSCERPKVSLSIHKTDTKDVPRKTLEKSGMKSSHSARPHVSHKPRDNHASRKPNYSTDDIDDTRPMDPSNNHASSPISMSSLSRDSGVNLRYSMSSGEELPTVSEVQLADALQGNATLKKVIKLIRQAFAYDGYLENGVEDLAMAEYITSLGKLSWQTFNNAISEKFCDLYWEEELVGDLYEAVNGQKPPIRPTSNTTNKHRSAVPKKPPRTKSSREGHTPSRQKAASATQSEKHRAHTVEKKMPPGSALTKSKAEVDRRSKVTVAKSQAPEEKKQATATRQESDSREKSLGSQEENKKARDARLGKEEQRTVPVLKPNRTALRSGFAASESKTKLSPPREGKVSTLRLEPRAAEESHEQGRKAGTGDSELMTDPGKNESYDGNDLRQRRPAVVAMVGNKSQGSPLRLNSPELAKDLGTNGRFGGRNGMLMQRQDEPLRKMDGIQNTTDESLQMSPSLEDSSIDLNASRTSLTSSLASSSILSPDKISQDDPNSSLNASLTSSHFTPSFLNSPTSPVHRSTSDSSDSTNRKIREMLSKSLNRRESQGSLSSTSSGNSRSQFNNSDTISLPSMSSFSESVDESRCGLPSGVLYRGESVDPTVEAYTQQLTGAGGTQHNVDAKIADVEQQLMMEKRMRSKTEKFYRKLLHNQQTKGADNKSMVTKVGKQALEMTKRIEFLESSRKHLEMLYAEQWGLELCFLYSLATSSGRMSLDLRPVDDNPLLAFKTSRNKVSLQAGQPAGFFTFLYARHALLQGFLHHFFYTYHYYTTSQELLQFIANKFASALGMSSQQAENRNKILNRTLDILQVWVEGFFDVDFKANPQLLQDVLVFISDKILPVDSNGQCLIQLIEKRQQDRPGTSLLVATQREDIRDQLPMDKVSGSKDSKGILGVSGRGRLKAGIMSCLSKKDSSKQIDSAYLPAGSMEKDGFSLSDHTSMSIAHQLTLLQQELFHCIHPVHYLNSRSKGIGVNTNNYDTAGGKGQPTPDAGEAPSLFVMSLGEDGAVRALLDHSKDVSHWVSAEIVSCSSTKSQLVLLSKFINVAKACYDLRNFATCVQILDALDSLIVRQVPAWRNLPSKVVTLYEELCEGKVLLQGDSESLVKADAHKGSPTLPPTLLFLMHVQQLEIGGFKLANGMYKWTKMKSIAKFVDQIRVFQEHAYTFDANRELQDLLRQRVLESCDQDIHVLAARHSSNVHQLQSDKSSRRLQNAFQKVRATLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5E1</accession>
    <name>A0A913Z5E1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046937.1">
        <property type="nucleotide sequence ID" value="XM_038191009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191009.1">
        <property type="protein sequence ID" value="XP_038046937.1"/>
        <property type="gene ID" value="LOC119721116"/>
    </dbReference>
    <dbReference type="GeneID" id="119721116"/>
    <dbReference type="OMA" id="DAEQWTI"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037265198" description="Peptidase metallopeptidase domain-containing protein" evidence="18">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="19">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="378"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="16">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="15">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="512" mass="56718" checksum="430884883E24E4C5" modified="2023-02-22" version="1">MTGKTLLLSVLLVGAVTVIHSFKMETSADAMMYLAYYGYLKPLTSDDGTFMTEAEMKEGISKFQYMANVTITGEIDNATLTMMNMPRCGCPDVIGHSLDAKRRKRYSLGSRWSKTDLTFRIDSVTSDISSREDIDSTLTEALQVWSDVTPLTFTRVYAPTEADIVINFFSRDHSDGAPFDGPGGVLAHAFFPENGRAHFDEDENWTIETYSGINLFQVAAHEFGHNLGLGHSNIDDALMAPFYRGYVPNFQLHEDDIAGIQAHYGEDSGSPFVTMKPEPTICTGNVDAVTTTRDRSTYIFEGTQVWKFESQTSRISDGFPKPIGDVFSGLPDNVDAALYYSRSGKTYIFKGSQYWRVDNEVVDAGYPLDIGSNWYGLPDDLDAAFTWSGNGRIYFVKGDQYYRFNGRVDYGYPRPLSVWNIPGNQVGAAVQWLNSRTYFFAPSSDGYFRFNDRNFRVDAGYPQSTATTWQGCNTNLVEEPGTSSDDDGNGVSGLAPGFLALVAAMLLGIIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5N9</accession>
    <name>A0A913Z5N9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046100.1">
        <property type="nucleotide sequence ID" value="XM_038190172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5N9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190172.1">
        <property type="protein sequence ID" value="XP_038046100.1"/>
        <property type="gene ID" value="LOC119720486"/>
    </dbReference>
    <dbReference type="GeneID" id="119720486"/>
    <dbReference type="OMA" id="TCKACSC"/>
    <dbReference type="OrthoDB" id="5955376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000659">
        <property type="entry name" value="Crumbs cell polarity complex component 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000471">
        <property type="entry name" value="Protein lin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="505"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="578" mass="63847" checksum="448695E5CA06A4D3" modified="2023-02-22" version="1">MHRSYHSRGRIGWNLRAHARVKSQENPALCRLLHRSLSKSCFSSLPTRPERVPKVPAAKVNSQDFISWWFSCSRFSRPFSQTFETMEVRLQRLVIEFCLLSCLSIVTTVQQPTPADFCASHPCENGGMCTSLPNAFICRCPEDYSGVRCETHSSEHVPETACFSNPCRNGGDCVSTGLQQFTCMCPTQWRGSTCEIDLDECTSNPCRNSASCQNTPGNYSCVCPIGYAGKNCEEDVKCMTNVCNNNGTCITLNEQQVCICPVGFSGETCQDRDLCSPNPCKNGDCIPSDEDPNGYMCRCHAGYTARLCDQQLHAACSHNGDTFYDGEVRDVECNRCHCRGGEWLCTKKFCGSIQVVFDFVADFNGIVRGKEDNFKRSLTTALATEFSIEESMIANLMVSAGSIHVEFELVALLESHLNIEDVAAQMLAKLDSGTYYFRFEETALFVDQSSVKFEKVEAPTEGPGAPVISNVVLVVVCVLVSLFLIIAVIIGTVVIIVHRRRSEKTTTGQFGGRETGEEHPMNNTNHTRHHNDLYNSVPNDNGSLASGGQEANDLKDINIDMFSKVAEPKGLKSGLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7N0</accession>
    <name>A0A913Z7N0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046840.1">
        <property type="nucleotide sequence ID" value="XM_038190912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7N0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190912.1">
        <property type="protein sequence ID" value="XP_038046840.1"/>
        <property type="gene ID" value="LOC119721040"/>
    </dbReference>
    <dbReference type="GeneID" id="119721040"/>
    <dbReference type="OMA" id="DLYHVRW"/>
    <dbReference type="OrthoDB" id="10439984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="36528" checksum="0FD50DBB859AE89F" modified="2023-02-22" version="1">MGDCLSNRLVVLGVALFAALYLLAGAMMAAVGLVAFLKMPVLFSTGCIIWVGFVVFLCGAVLFLMSVCNKEVSLHKSYLMILLCLTVLLVSIANIVLIETIEWNGVRVEKVSQDIDETMMEASNSLTIFLTYLLGLLGSVIGLVASFFGMIYIYFTLSVPLLKATQKSKPQHEVKMKRSLCDKYRNKPPRKFNFKLTPPPDSKVQATTRWHDDDADLYHVRWVYDEQSPGPRPNEDETPAGGSGEQRAADNKALMDEIKEKVGSRRLPSTSLDVTAQMNTSMTTQPDGTSQGSLSEDLVLGRIGQLPPNARSSFRRHSNEESDKKVAATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8R6</accession>
    <name>A0A913Z8R6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048044.1">
        <property type="nucleotide sequence ID" value="XM_038192116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8R6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192116.1">
        <property type="protein sequence ID" value="XP_038048044.1"/>
        <property type="gene ID" value="LOC119722093"/>
    </dbReference>
    <dbReference type="GeneID" id="119722093"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="620" mass="71390" checksum="20014D8C32B89995" modified="2023-02-22" version="1">MDVQPGHCWFCEKRLQQRTVPCDGCPVAVYCTTSCRDRDKVRHGAVECEIFQAKKCSTCGKRGKTLECQGCNDAWYCDTDCQRHGWQSHKAKCKEIMASVKQLSLELRYPTYFDFPSYIGRETAKDFLQLENNELSSDRVENEQLTQEYHVLSAGCGNLRNTVLTAGSLPDKYQGKLHITLNDNDPFVMARNVLFLFMLVRFADTDCIASSLTTIWYSLHISEREYDLIKTSLDELIQMSAQQLHGATKGLVSVLDEDLNYLKPVWEQWRALECQRDKKASINLKQQRKIMFENDPNAKLNHLLYLNRINEKDRKMMEEWLGHGLFFPYEAKEKDMSFDNPTLTAPKASETVAGEDARLFLLLNNAQAEPQEDATHFVYCIYPLAIPFEVWDCLRVRENTPGSHSSPMVMYHKYVTNLLQKVKSLILQGRLLIRVSLANSLDFPNHHQTLSMPNYDRIFTSNLADFVGLAKLLQTMKPLLNANNSYSAIITEIVHWADKVPGAKLENPSEIQRAKLKSYLINDRMTGIPLKQHTWVSDYFNDTSHFLQYLRADIMAGGLGIPSLKDVPSFESVKKYHGMEMRDFRKGLNKLVPFRYLRNKRDLNINNGTDRAVEWYLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAY8</accession>
    <name>A0A913ZAY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4 13">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_038048749.1">
        <property type="nucleotide sequence ID" value="XM_038192821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192821.1">
        <property type="protein sequence ID" value="XP_038048749.1"/>
        <property type="gene ID" value="LOC119722623"/>
    </dbReference>
    <dbReference type="GeneID" id="119722623"/>
    <dbReference type="CTD" id="4905"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000006">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000003">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="16">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="256"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="569"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="903" mass="100885" checksum="09F2B9E483BE08FC" modified="2023-02-22" version="1">MARIRVMKAARCPTDELSTSNCAIISPGDFDEKTKHIEVKTSPSSRFIFSVKDHPSIQRGTVGFSLPQRKWAVLSINQDIEVTSYEFSKNSQLIGWITLEVDFLQKKNNTAEAYDTDKMAAEFSMAFSDHAFTVGQQLVFKLEGKKLLGLVVKEMEACDISMLKGGRSSSQRTKINIGVSFPNTQVLFEKAESSPINLTGKSVGKAGGRQSIINPDWDFKNMGIGGLDKEFSDIFRRAFASRVFPPDLLEQMGAQHVKGILLYGPPGTGKTLMARTIGTMLNSRQPQIVNGPEILNKFVGESEANIRKLFSAAEEEQKRCGANSGLHIIIFDEIDAICKQRGTMSGSSGVHDTVVNQLLAKIDGVEQLNNILIIGMTNRRDLIDEALLRPGRLEVQMEIGLPNEEGRMQILDIYVSKMRENKKLADDVKIDKLASLTKNFSGAEIAGLVRASQSLAMNRMIKASSKVEVDYEAAQKMQVQKSDFMIALENDIKPAFGVSDECFSKYILNGIINFGEPVTRVLADGELVVQQTKLSDRTPLVSLLMEGRSARDWETSSIDWVPTLCLGHDKVKRPSQGTTERKERAKKRRKVQHEIKEAAKNRQESHEACSHPTGTVQHGNQSPLLHSSTSQADDPHKDTENARPNLQDVMSQADLTGQDIICIVHHTLYQGEQISQLHDQVELTNSVSQASLAGNDKKNRYYTGLPTYTILMAIFNLVSPHIVVTHRSAMSKFQQMMIVLMRLRLNLSECDLAYRFDIAQSTISRIFNLTLDVLFARLNSLILWPEREELHLTMPMQFREHFGKRVAVIIDCFEVFVDRPSNLLARAQTWSNYKHHNTIKYLIGITPQGTISYLSKAWGGRASDKHITENCGFLMKLEPGDLVLADRGFDIAESVGMQCAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBA8</accession>
    <name>A0A913ZBA8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048311.1">
        <property type="nucleotide sequence ID" value="XM_038192383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192383.1">
        <property type="protein sequence ID" value="XP_038048311.1"/>
        <property type="gene ID" value="LOC119722332"/>
    </dbReference>
    <dbReference type="GeneID" id="119722332"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="63"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="48982" checksum="F6B3AA611F44C01E" modified="2023-02-22" version="1">MATESLNTSYASTCNCNHTDMRVLVANNHHPVSNHASLNQISIGNVSNSTSSSQMIKRRTRLVEKDGTCNIQYENMSKSRWCKIIKDIFTSTVDMPWRYNILMVIVGFLASWLLFAVLYYGLAIARGDFDHLDDPEWKPCFRNFQNFKSALLYSIEAQTTIGFGFRSPTEQCGEVLFFLIVHTLWANFIEAFILGSFIAKVSRPKARAKTLQFSHYACMTKLDGKMCFTFRVGDLRQKSHIVEGHMRLQMVRHYVTKEGTVIPFKFLDLNIGHEFGADRLFLVWPLQIVHVVDEKSPLYSISRDHLRHMDFEIIAILEGIVEATGTTTQARTSYLPDEIMWGFQFENMVEVRDDCHFVDMKRFHMMRESEDFSRCSAKEVDEMREAEDREVDRDSVWTSRRNSGIIRRSSPILRDAENVESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCK5</accession>
    <name>A0A913ZCK5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048665.1">
        <property type="nucleotide sequence ID" value="XM_038192737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCK5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192737.1">
        <property type="protein sequence ID" value="XP_038048665.1"/>
        <property type="gene ID" value="LOC119722549"/>
    </dbReference>
    <dbReference type="GeneID" id="119722549"/>
    <dbReference type="OrthoDB" id="10691312at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="657" mass="73488" checksum="C59B207E56C7C5D0" modified="2023-02-22" version="1">MANDAVPFESLGVIGVWTPSTTEDNTEIKLPRIGRSASNDSEMVSSSRTLPARDRSELSASRLSPRPGRKLRLSVEQADRSRHRSVSPHSPRDPRPITRQSLTGQDASLAGSCMRDFSGKSPPRDILKSRQCFIRESEPSIIEPNSGGKLPSPRLRKSSKLSSPVFAKKTVSPRSVKKNRLGNQTGVIESELSTSLNSNFTKGCRPPRLSRAKQSSSTESEDEKDSPRGLSPLPPISVSPRDANFLTNNESKTSIKHVEFVEVDARQPPGKPDSSSEEKQQQSPIRQRSSTHQVVKSRSLDSEPVVPNQSKQTQQTRPTPREKTPNWLLEDHPSLQFSDQASAHIDCNNVEEFFTDRIFDRIPLPDRSNIFQQALDDMKSSPTRPSSHGSDPGDLHIRRSSLVTNFLDLAALRDSLQSPKTENDSQLDVMSVVPEGETYKEPHLTASAAQKVSNWAERSRKVSTPTRFLSVDQKPATRSASPKRRVVSEIQPPRMEFLEPKTDKPRSKTISDSKSDSALISPSIRRKDGAWSTHSDISEISRPLLSKRAMCYVMKFIESASSIATSHRATAQSSNHMSRDNSVFPSIPNRSARRSRDRRDSIRIVQQLINERSPSGDTTEIASFDDLRNCRYLRNIRTGDGRKEAFRTIKKTTYHEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEA6</accession>
    <name>A0A913ZEA6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049809.1">
        <property type="nucleotide sequence ID" value="XM_038193881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEA6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193881.1">
        <property type="protein sequence ID" value="XP_038049809.1"/>
        <property type="gene ID" value="LOC119723320"/>
    </dbReference>
    <dbReference type="GeneID" id="119723320"/>
    <dbReference type="OMA" id="YHNDING"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="186"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="44881" checksum="E32AD213C47C8C0D" modified="2023-02-22" version="1">MGTNTFYNMSRWAAFWCKRALLRVVFRSFLLMSIILLSISIMVLSPNLYSVNEAHRPTTVSALVTGRQSINSTLHCAIQNGSLSTFARKYANHYTANDVDFLVAVDIIMKRKWQQNSAFSQVFRNDLRAALGDKGKLDRFILTRQNVRWGDKINFYRHKASARISRQLWQLLPKDTFFKPGIIQRCSVVGSSGILKGSQCGHSIDKADFVFRFNLADVKGYETDVGGKTNFTTLNPSLIMIKYSSLRRKEDRTRFAEALKQFKGSLLFLPAFAFKWRYQMLIQAASVAKKSVGLQPIFGHPDHYTSVANLWQKTINGTRWTTTGLHVLSSILDFCEQIDVYGFWPFPTTLDGRAVSYHYHNDINGTTSHSFGKEFRGLVYLHEQGIIKLHIGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFG8</accession>
    <name>A0A913ZFG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049715.1">
        <property type="nucleotide sequence ID" value="XM_038193787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193787.1">
        <property type="protein sequence ID" value="XP_038049715.1"/>
        <property type="gene ID" value="LOC119723225"/>
    </dbReference>
    <dbReference type="GeneID" id="119723225"/>
    <dbReference type="OMA" id="SSARCYI"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="48669" checksum="7F628D87999DA734" modified="2023-02-22" version="1">MENIFTSNATATNGSVAEEHPFNVLYTIRLITNILVFLLGVPGNCLILRVYWIKTRKTSTDILIRALAWADLAVCFLRIAEIIYISLYLAAEYSMYSFPPGPGLFILYAVIIALAGAAVVSSFSITAVIAVDRYDCVCRPQKRIFNPRRSKIVVLVTVLFAFAINVGQIAHNICLRTSCTEHASVHVYWDIGVKAEPVLFVIALVTIGVCYGKVYVTIRKHVKVGPVQAPTARDAERIPSDLRVGHQVNCSTRPTPPQQNIDLPTSESFVEEAVTKFVHPPSTSSSMHANSHQAKPNDVCTAAHVVSFAHQDSSGPSQPDVIPEPKAAPQDNTPSQRQSRQEPGHAPQRVGAAKLQRKTTRMLFITSVVFLLTWIPYLVFNVKYYAAPNFDDFQEIIGAISIILLINSVVNPLIYGIANRRFRNDCKEVIRKIKCFKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFR1</accession>
    <name>A0A913ZFR1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine protease 16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049891.1">
        <property type="nucleotide sequence ID" value="XM_038193963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193963.1">
        <property type="protein sequence ID" value="XP_038049891.1"/>
        <property type="gene ID" value="LOC119723363"/>
    </dbReference>
    <dbReference type="GeneID" id="119723363"/>
    <dbReference type="CTD" id="10279"/>
    <dbReference type="OMA" id="HYAEHFG"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000003">
        <property type="entry name" value="Serine protease 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037378984" description="Serine protease 16" evidence="6">
        <location>
            <begin position="22"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55134" checksum="8BECEF77208F93D5" modified="2023-02-22" version="1">MAVHRLAVLIFLTFFVGLAWSLPRFLHGRPRGGMLGAPRRRSGGSLPPDQWLEQKLDHFNDADLRTWQQRYFVNDTFFKPGGPVFLMIGGEGTANPIWMVEGTWVVMAERLGALCLMLEHRFYGKSHPTPDISVESLSFLNSEQALADLAYFRQYMGMKMNVTYSKWISFGGSYPGSLSAWFRLKYPHLVDGAVATSGPLLAQLDFTGYVSVVRDSLATSPQGDMCNTNIMQATTQVEQLLQHRVGWADLTKMFQVCKPLNGSNPNDVSNFYEAIAGNFFGVVQYNKDNRAFEGAVGTDITIDTLCGIMGNTSIGVPLARYAAVNTLLLQTYGEKCLDVSYDDMITEMRQTSWESSASEGGRQWVYQTCTEFGFFQTSDGKDQPFGNGFPVSFSLQQCSDIYGKQFNKTTLTQGIARTNTNYGAKGIRATKVIFPNGSIDPWHYLGITKDVSETETAVYINGTAHCANMYPALPSDPPQLVQARDTIFKAVEAWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGN7</accession>
    <name>A0A913ZGN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050177.1">
        <property type="nucleotide sequence ID" value="XM_038194249.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050179.1">
        <property type="nucleotide sequence ID" value="XM_038194251.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050180.1">
        <property type="nucleotide sequence ID" value="XM_038194252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194249.1">
        <property type="protein sequence ID" value="XP_038050177.1"/>
        <property type="gene ID" value="LOC119723545"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194251.1">
        <property type="protein sequence ID" value="XP_038050179.1"/>
        <property type="gene ID" value="LOC119723545"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194252.1">
        <property type="protein sequence ID" value="XP_038050180.1"/>
        <property type="gene ID" value="LOC119723545"/>
    </dbReference>
    <dbReference type="GeneID" id="119723545"/>
    <dbReference type="OMA" id="IMEGFTH"/>
    <dbReference type="OrthoDB" id="5983955at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="740" mass="82639" checksum="1D38B9C4CAA60F36" modified="2023-02-22" version="1">MEAADRAASLLVFHRDRLNKLRNGISRVLEAFADVLDDKGGISGNEHAEVKKKLQEIEDTSWSRIREHFLDSHEPSDEPREGRNIARILLDFTDKLDDVKDALDDRLRELAQKKESKLQLDVKDLQKKLAEEKTKTADLRWKHQELAESSSSEKHFKGVLQQQLKEKQDIIAQLQRNGTVQLWEKEKAKLLEGSRQREENLTRELTQLRAAHEDMKDRLNRRIKDLEEKVRLERMKDIVSKLASKDEMEADVESLKRQLYTKEVDLARLDQELINQQRLIVGCIKGIQRDFRVMGERQEGRRLRKDDMQKMNLILDAILTGAKEARLDITKADLPLHYIALPEDIVAHPVKRMTRPSILAPVVNRHLETIGDSPSTSPTSSPPDSPSQPQRRVPSLELPHPSSSPALSSLGRASTVPLIETPPANGQSSATGAANRRAPSGRAKISVDEVGLITKSPRGGSQKAPNPNTNTSARSPNVARKLRTTSVSESSRSPSLRRRAVSSPVPPDLAALVKPPASLSPRETSGSTLVPRQPSRSPSPGGRNGMASARKPRGSGKLQASNGNKDISKENDNPAQDSKPKPKSTLTGHGELNLEKGNQRGTPFSLNAAHFFRKDHPALIDKETGMLDAATARTCFPHISEEQIREHYQQFKKYDTNGDYSLDFMEMTQAIQSTVADYYKPRQIKEAMVEVDVDQSGSVDFYEYLGVSTMLMMKIGKSEIFRSSMVKHAGGSISKVCSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGR3</accession>
    <name>A0A913ZGR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosylglycohydrolase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050236.1">
        <property type="nucleotide sequence ID" value="XM_038194308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194308.1">
        <property type="protein sequence ID" value="XP_038050236.1"/>
        <property type="gene ID" value="LOC119723584"/>
    </dbReference>
    <dbReference type="GeneID" id="119723584"/>
    <dbReference type="OMA" id="LNAHCAR"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF34">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47871" checksum="E632962EDD317546" modified="2023-02-22" version="1">MKTFNLRRVVAVGLAGICLATLRRCVLHLQYSTTTQITGGSGNCEHDKKMAQSESLWGMVVGDALSMPVHWYYDPDDIRRDYGDWLSGFVAPKTRHPSSILTISAVGGAGRSGYGSGSDPVIGSVILHDKLKYWQSNQRSIHYHQGMKAGDSTLNALVAGLTAQTLASEYQDQQPMDDGAYGAIFAAYVKFMTTPGSHGDTYAESFHREFFRDWLTAGSPVVSEEVLAFAESRSKKLTSSHVDHNIDSIGALVMPISVILHCANLSTTEAVKHAVRLVNLTHCSLSLVPFVELYATTLHSVVNGASLREKAQAALESPLLGGSNTWKRVKKYSQLAARYAEGSEERLQVYQEAVSHFGLACYIKGAVTSMFFLAYEFHDNFEAGALTNTNCGGENCHRGAALGALLGAEAGRNGREIPQQFKSGIHSAQETIQDVIEAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH51</accession>
    <name>A0A913ZH51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050381.1">
        <property type="nucleotide sequence ID" value="XM_038194453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194453.1">
        <property type="protein sequence ID" value="XP_038050381.1"/>
        <property type="gene ID" value="LOC119723668"/>
    </dbReference>
    <dbReference type="GeneID" id="119723668"/>
    <dbReference type="OMA" id="GMMRFCT"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29307" checksum="4F7F5915C88D1390" modified="2023-02-22" version="1">MAFSTRCFSGLFRLKLVPKLSLRYVGSDGIHRVHKHGGMGMSEGAQLTWLMTSGNVLKRLMSGHTMKVTLQFSRPMSQLSNDDADTQRMQRVFEQSSRQQTKGDGGSRLIYEVRGLGMMRFCTLFFYATALVGLYMSPDLISSALEHETVNSEMIFGFLSVGFGVVVLPVLLTMFNSRLVLRMYYSEVHKSYVAMTQTPALTLRRAEFRLSDVVPTVKNPNSILGYFKLNTLTAKGRPYFVNPYNFKLPSDFNHLMGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHN5</accession>
    <name>A0A913ZHN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050550.1">
        <property type="nucleotide sequence ID" value="XM_038194622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194622.1">
        <property type="protein sequence ID" value="XP_038050550.1"/>
        <property type="gene ID" value="LOC119723773"/>
    </dbReference>
    <dbReference type="GeneID" id="119723773"/>
    <dbReference type="OMA" id="GCYTFRN"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF176">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038158498" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="34"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="758" mass="85575" checksum="7126FE9127BF400D" modified="2023-02-22" version="1">MTQMLGGCRALRGLFAAVMAVVLVGLAGRDCSAFYLPGMAPVSFCSKDTEVRYKTAGNSLDSQCKSQIEMYVNRLDTVESIIPYDYDRFDFCQVPKTEDVRPVENLGQVVFGERIDASPYNFTFSKNEDCVKVCEKTYDPKVKEQEEKLTFLQKAIMLNYQQHWIIDNMPVTWCYTVEGDQKYCSPGFPVGCYVDKQGIRKDACVIDTNYDQKDTYYLFNHINFTIMYHRMSENEDLARIVSIKVEPHSINHKKTGGKCLTSVSENPVSAPMAIPAEIKEPISISYTYKVEYELNTKIRWASRWDYILESMPHSSIQWFSTINSLVIVGFLLLIVGRILHHNVYTGEDSVKKAGSERARDFRWKLLHGDIFRPPRGCMLLSALLGSGTQIVLVAFITLVLASVGLLSPARRGALMTCIIMLFVCLGLPAGYISTRMYKAFGGEKWKTNLLLTGLLVPSIIVAIVLILNVLMWTWQSSAVIPTSTLLTLLAMWFGIQLPLVYIGGFIAFIRKPIEFPVPTNLTQRRIPRQPCIKHPVLAAVVSGGLPFSCIFIQLFFILNSIWMHQFFYGFGFTLCTAAVMVVVCSLITILFCFLHLQSENYHWWWRSFLSSGFTAVYVLIYCVYYFVSKLTIQGTASTVLYFGYTSIMVLLFFLFTGTIGFFSCFWFLLKIYSSLDPSQLELNSDVEDEKDMPQETMNVGVVKEEEKEEDIANEAASNQEDGENPPPIIEVGKDNADTVQQDVSVVGGNSEGELTPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHU9</accession>
    <name>A0A913ZHU9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050969.1">
        <property type="nucleotide sequence ID" value="XM_038195041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195041.1">
        <property type="protein sequence ID" value="XP_038050969.1"/>
        <property type="gene ID" value="LOC119724117"/>
    </dbReference>
    <dbReference type="GeneID" id="119724117"/>
    <dbReference type="OrthoDB" id="10043991at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="501" mass="56777" checksum="99C639CAB75C2D60" modified="2023-02-22" version="1">MTGGQGSTERHYRRLLDKLKARSSRIFVKTQMQNRMQEQRLKKVVNVLEKDRDPCIRKSHEGIWRVSSKECPMPRLAKPEGMPSYLARPRATTLPTPAELATLLPKKRVRGQQHYASHAESVATSKPPPREYTKMSKRRLSSMRSDQVQIYHYRKVMEEFEEAVEVFPEGNGTEEHATAAGGTGEKMETPTQGDRTDGKWATPVTRTKSVISEASKALADNESTAAAEESVRIVMKKLGIRPQSSPMSYSRRPRPKKRRPQTSVGTCATIAEQQLDSNSKVLRTNYLDMYKAQLKNHVRRMTSKGEMPAPSICIDDMSPHHGHRDERPKSGLDMSVLSQASTPTKAPSLAHSKFSSPAFSPESRGISNNPGAKIERQSTLMQQTASSTSRSTPRCQMRRVSTQIMHATTFDTLQDEVQKMQSYRKFRRESLQMDDVANLQDLEDGELFEEMKHCRYIRWAKADEALIEESSENEPLQHQLALLTLKYVSQGQSKKSRNENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIQ1</accession>
    <name>A0A913ZIQ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase FkbM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050935.1">
        <property type="nucleotide sequence ID" value="XM_038195007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050936.1">
        <property type="nucleotide sequence ID" value="XM_038195008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIQ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195007.1">
        <property type="protein sequence ID" value="XP_038050935.1"/>
        <property type="gene ID" value="LOC119724099"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195008.1">
        <property type="protein sequence ID" value="XP_038050936.1"/>
        <property type="gene ID" value="LOC119724099"/>
    </dbReference>
    <dbReference type="GeneID" id="119724099"/>
    <dbReference type="OMA" id="VNVNDCL"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052001">
        <property type="entry name" value="MHC-II_Gamma/Thyroglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093:SF21">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093">
        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="6">
        <location>
            <begin position="125"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="562" mass="62772" checksum="9F354DE206B5866C" modified="2023-02-22" version="1">MAPFQRSAVIYVIFGFCLGLMTSTLFGGSISYLGGCNQPVVSNTHIECKYPDSEVRALTVGEIAKLDSNPNLPPNNSDSINSVKPEVPERKPEEPEVKPEVSEHKAEVSEPEANARRTPRKILLDCGGNVASTVLLFRETYPGGQDYIIHSFEIDDRLSPYFKPYDNHHLHCPVGVAGQNGNLTAYSEMVWSPSKGLNHGADMQWGGGSLFVSSKEKQNEKTGGYRQLSYRKTIPVIDLSQWIVDNFSKDDYIIFKLDVEGAEYAILRKMIDNNVMAYIDKFYGEYHDWQPTGWSKADKAQIRTDIKKAGFSMIDWVGERRKYSDIEKMNPIKVPAGTPGEAGKVYTNCASGSVTLTVAVGMNYKRARRVVETLAAHKYNVPITLFVYGDFVQRNSEAVKTWSEHFNIGIREDGHNPPGHLELMPGAWVRMGLISSILRLEEIGITASYYLPTVQGDASTTILDEAKNRGLRVIKPVAEFPAKQGTPGELTWDNYYKNRDVERVPKALRKIHDALAKNTGGVLTVDSDLPDTYMNSVFMMDYLVETSGFKLVDLKDCVSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJJ4</accession>
    <name>A0A913ZJJ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051240.1">
        <property type="nucleotide sequence ID" value="XM_038195312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJJ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195312.1">
        <property type="protein sequence ID" value="XP_038051240.1"/>
        <property type="gene ID" value="LOC119724318"/>
    </dbReference>
    <dbReference type="GeneID" id="119724318"/>
    <dbReference type="OMA" id="IENDCHK"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="255" mass="28598" checksum="880B702336C42216" modified="2023-02-22" version="1">MGFRYVVRQAKPADCGDILRLIKELAEYEGENPDQVVKNTEQDMQNDSFGDQAFFHCLVAVATDDDIPPGDCGEAGRGTVVAYAMYFYAYSAWVGRLMYLEDLYIKPTHRGLRNDSFGDHAFFHCLVGEAVDEEEPTVKGTTVAYAMYFCAYSTWIGRLLYLEDLFIQPSHRGKGLGKAMVCKVAQIGAEKGCKGMQWIVQESNASARQFYDRLNAVDMTENDGWRVIGSRGENFTNLANSLQNPVSKNNNITFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKR6</accession>
    <name>A0A913ZKR6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal transducing adapter molecule 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051641.1">
        <property type="nucleotide sequence ID" value="XM_038195713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195713.1">
        <property type="protein sequence ID" value="XP_038051641.1"/>
        <property type="gene ID" value="LOC119724601"/>
    </dbReference>
    <dbReference type="GeneID" id="119724601"/>
    <dbReference type="CTD" id="8027"/>
    <dbReference type="OMA" id="CDKVTTN"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21388">
        <property type="entry name" value="GAT_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11820">
        <property type="entry name" value="SH3_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000009">
        <property type="entry name" value="Putative signal transducing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66458" checksum="8012FBFE0AC43338" modified="2023-02-22" version="1">MRTRVLRDLVIYGSSSSIGSSDFFSRQKMPLFGGSSPFDQDVEKATSESNKGEDWGLIMDICDRVSGQPQAAKDVLKSIMKRVRNPVSQVCLQALTLLGACVSNCGKTFHLELCSRDFMSEARNIVSKGSGKVSEKIRGQIKEWAEEFKNDPQLNLMVQLYDSLKAEGYDFPATSQKTSQSTKPAPVTTPAPAASSRQEEDDIAKAIQLSLQQDKAKTSSLYPSAGLYASMTPSVSAATTRREPRKVKALYDFEAAEDNELTFKAGEIISVLDDSDTNWWKGENSRGTGLFPSNFVTADLTAETDADIREREKKVSFDEEVEVRTIESMAPEVVEIDEGQMDSCLEMMQNADPTEARPDTQEMLVLEDTCKRMNPLINQELEAVDREHMDLTALNAKLIDAFSMYHKLMKEAPVYGYSLKTMNMPQQGVAGQYQPGVAGPGMPGFGEVPYGAPPQGMYGPPGVQGQMGQPIMQQGGEMAMPQGQMASGMMTQGNHPMTMAQPGQAMYSHPGTAQQYQTQPGPMAHNNMTHYQAPPQNSMHQMSVNTSTSYSAQGSVPSGVQGPPIMAQNYSGAPVGQQPPMGTHPQQLQQPMQQQQQQQQQQPMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL35</accession>
    <name>A0A913ZL35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052507.1">
        <property type="nucleotide sequence ID" value="XM_038196579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL35"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196579.1">
        <property type="protein sequence ID" value="XP_038052507.1"/>
        <property type="gene ID" value="LOC119725215"/>
    </dbReference>
    <dbReference type="GeneID" id="119725215"/>
    <dbReference type="OMA" id="WVIPREM"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35404" checksum="4383D05567F7FACA" modified="2023-02-22" version="1">MVDIFSSRKMATSEKAPSSEQQVRLITWYIPRSTSTVLSRCLSSVVDTKVFLEMFGNVSLLHAEKTEDGAPNVSKTEQGLNAFMEEASKVTGISAGIDASQGTYQWVKEQFEEAHPGKRFIFAKDVAYAITGHLECIPKGYRHLFLIRHPLKVFVSMKKLLLQSLKDVSPEEVRLDEMPLNYLPKGFGYKETLELFEHIKKEIDPEAMIVDSDDLLQDPKGILSAVLKDIGLPFDEKMLHWESGDTVNKDWVIPREMLQANTMANFYKNALDSTSFLKPKALPDRASIAPDILRVVDASMPYYEKMYSQRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLB4</accession>
    <name>A0A913ZLB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-aminomuconic semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aldehyde dehydrogenase family 8 member A1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-aminomuconate 6-semialdehyde + NAD(+) + H2O = (2Z,4E)-2-aminomuconate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14469"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:77634"/>
            <dbReference type="ChEBI" id="CHEBI:77859"/>
            <dbReference type="EC" id="1.2.1.32"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid degradation; L-kynurenine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.32" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038051835.1">
        <property type="nucleotide sequence ID" value="XM_038195907.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051836.1">
        <property type="nucleotide sequence ID" value="XM_038195908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195907.1">
        <property type="protein sequence ID" value="XP_038051835.1"/>
        <property type="gene ID" value="LOC119724724"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195908.1">
        <property type="protein sequence ID" value="XP_038051836.1"/>
        <property type="gene ID" value="LOC119724724"/>
    </dbReference>
    <dbReference type="GeneID" id="119724724"/>
    <dbReference type="CTD" id="64577"/>
    <dbReference type="OMA" id="PMPIAAW"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047102">
        <property type="term" value="F:aminomuconate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07093">
        <property type="entry name" value="ALDH_F8_HMSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000021">
        <property type="entry name" value="Aldehyde dehydrogenase family 8 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="483" mass="52929" checksum="8A3CEFE839A0216D" modified="2023-02-22" version="1">MAEIVVENFIGGEFLRTESYLDSYDPSTGEVWARIPDSGEAEIERAVQAAKSAFPGWSSTPAEERSRIMQRIADIVESRLQEFAEAESRDQGKPVSLATRVDIPRLMHNFRFFSTSILHMTNSSTLLDKAGAVNYTTQTPVGVAGLISPWNLPVYLLSFKIAPCIAFGNTCICKPSEMTSVTAWMLAKVFNDAGVPPGVINIVFGTGPRAGQALVKHPDVPLISFTGGTATAEHIIKTSAPFCKKLSLELGGKNPGVVFEDADFENCVQTCVRSSFANQGEICLCTSRIFVQDTIFDKFVERFVQETRKLKVGPPQEASSNLGALISKEHLQKVKGYVAIASQDGGTVLCGQEKETLELPEKNKNGYFMRPTVIVNVPDDTRSMQEEIFGPVTCINSFKSEEEAIQRANNVKFGLSACLWTQDVSRAHRVGQKLQAGTVWTNCWLVRDLNLPFGGTKASGIGREGATSSREFFTEEKTICIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLS0</accession>
    <name>A0A913ZLS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052279.1">
        <property type="nucleotide sequence ID" value="XM_038196351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196351.1">
        <property type="protein sequence ID" value="XP_038052279.1"/>
        <property type="gene ID" value="LOC119724985"/>
    </dbReference>
    <dbReference type="GeneID" id="119724985"/>
    <dbReference type="OMA" id="MAICCEA"/>
    <dbReference type="OrthoDB" id="5810838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="86"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="393" mass="43872" checksum="16FC8AF700F830A0" modified="2023-02-22" version="1">MPISILSRMGEKSGNSAWKTQWTTTVGDMMDDTFAYDDQQPVCSIPDAPILNLSDPSIATRYEYNSVQSALVTIIYPCICLFGILTNSIFLLTVIRVPHMKNITNIYLSSLAVSDIMFLITGTGFGLWRYLSTPVISDFSFLGGVHGCLITQVLNSTPFYASTLLVTVVAVERYLAICRPIHHRKINSRGRAFALIAVTWVVALCCEAMLCPTVSDYTVKCVIWPNDDYFMEFPQTIGGCFYPALWAQILTAFALIVPSLLAIFVTFILYILIVRKLSKRIHKAPSEQTSNRAKSRRTRDHVAKMLITAGTVFYILLTPRTVVTIYYYIKSFAGTPGLPPGVEFILFTSTNILLYVNSVTNPIMYAFSNKRYRTAFIQAFCPGSKMINVSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN37</accession>
    <name>A0A913ZN37_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053208.1">
        <property type="nucleotide sequence ID" value="XM_038197280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197280.1">
        <property type="protein sequence ID" value="XP_038053208.1"/>
        <property type="gene ID" value="LOC119725731"/>
    </dbReference>
    <dbReference type="GeneID" id="119725731"/>
    <dbReference type="OrthoDB" id="10186997at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="365" mass="39054" checksum="88EA558B8FB4183D" modified="2023-02-22" version="1">MFPKNTMPTTVAVPEKPPLQTHKDSTVLYMVGGDQVDGNDSRWQFKRAKICACTVVITTLILVVGILGAITIVLRSQQGTSEAPTVYKEPLLGNDSPLEEPINKIPRIKIDDGGLWPPKNPVTPDLVAVDGMGTVSLSSSPKPVTDGIDIDPEGDAIFEPFVFSSDQGRTYISSSFPYDGFYMRGEEGHPPPSHSEDSSSDPTSEAPGDMDSDLDSSLSYRIAGRTYASSSFPYDGFYMRGEEGEPPPSHSEDSSPDPTSEAPGDMDSDLDSSSSFDPYDGRTYISSSFPYDGFYMRGEEGEPPPSHSEDSSPDSTSEASGDMDSDLEGSAEPDDSDIPSDSDNSSSSDPSSSSSGLPSNYRIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNU4</accession>
    <name>A0A913ZNU4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053463.1">
        <property type="nucleotide sequence ID" value="XM_038197535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNU4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197535.1">
        <property type="protein sequence ID" value="XP_038053463.1"/>
        <property type="gene ID" value="LOC119725923"/>
    </dbReference>
    <dbReference type="GeneID" id="119725923"/>
    <dbReference type="OMA" id="LSVESHC"/>
    <dbReference type="OrthoDB" id="10070760at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF8">
        <property type="entry name" value="LD11117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037793677" evidence="12">
        <location>
            <begin position="23"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="612" mass="68672" checksum="B9EDD31686B5A26D" modified="2023-02-22" version="1">MEATRFVFALIFGLLLIGVCMSRPAKKTNVRRHKAREYEFSAPSQACGFQCNDGSCIPAYWECDGIVDCSNKEDEDHCGGSKSVPASYGIGCPPWMFECYDGTCLPEYVKCNGYNDCSYGEDENWCPSPTPKGCNSYQFTCNDGSCIPSYWLCDGIVDCSNHEDEIGCANKTTNAPYPPDPVTSNYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDENWCPNKTTNAPYPPDPVTSNYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDENWCPSPTPTKGCNSYQFTCNDGSCIPSYWLCDGIVDCSNHEDEIGCANKTTNAPYPPNPVTSNYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDENWCPNKTTNAPYPPNPVTSNYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDENWCPNKTTNAPYPPNPVTSNYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDENWCPGPTPIYSQGCNPDQFTCDDGKCIPSYWKCDGIVDCSNKEDETGCGNKTTGSPSYEPSYYVTPDYGCPPWMFECYNGTCLPEYVKCNGYIDCSYGEDEYGCNEMSWLERATKRKSTKRARRSGQPQRTHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR99</accession>
    <name>A0A913ZR99_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PKD/REJ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053616.1">
        <property type="nucleotide sequence ID" value="XM_038197688.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197688.1">
        <property type="protein sequence ID" value="XP_038053616.1"/>
        <property type="gene ID" value="LOC119726071"/>
    </dbReference>
    <dbReference type="GeneID" id="119726071"/>
    <dbReference type="OrthoDB" id="8178002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640620" description="PKD/REJ-like domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="3315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3273"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/REJ-like" evidence="9">
        <location>
            <begin position="2550"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1415"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1804"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1428"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1848"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1861"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1906"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1930"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1959"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1974"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2157"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2319"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2374"/>
            <end position="2391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2405"/>
            <end position="2416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3315" mass="358021" checksum="ABA1D108FBB42D14" modified="2023-02-22" version="1">MGRQIFLIGTLAVATCVCLFPALDGKPSPQRPQVLRRGCIQMRLAQDGDPQLDLPDLPSAIQTTFDRFSESWLLGRESQKERMLQASDVQTLIEESLPKLALIDAYGELAHQAASASKTWGGIVRNVTLEYSRGLMQDALRNSDQQTTVMPVLPGPGGRQKRSSITPPPASEEVTYGYPSFSVPPLMDFDISERADLLRKLAYYGVLFFKEETTRVGEGAPTTESSSVPHAAPFESFLDSLLAAHISGVMKPVVAGPGMFGNDGVTGGLLDGWTGIFGSFSRDDLTTHETTTDSGDNNPIDFDPTGGLQFVSLLRTLQGQVQRWIEEDSPDRPALYQVNCSMVGEDRSSSVACRVCPPSETSADADRVIDSLSSKLMEPFSLLRLELQDVSESIEGRYRDWIARMRRQENANYWTIVGERVLAWRLEVERGWKGVEEWARGHHTITENRVGCCCLSLWPVQAQDIRTPNVLPIGDNDCSTRVGETMARVIEGAGFPTAETDWLVKLVQAWTKLIQKSEVSWTDQVRAAVETSKTDLMKIGVYKRLFQQIKPTLNRMKMTFRASADTTMFGEAEQVDLAQEFEKFGFYGLLMYPRAELLTQLQIETRNWQAQPSQREANFELYLAKIFALLANQVYDAFQITDANGVGFAGRTNGTDYSSAEIAARQKFSDTIQSPISAFAEIKKLAFNGTFKGEPGFTTMCVADTGECLFCGSQVFKALATEGGIMEQLESYHDLMLSADLLLAEYLQSIGDKNPATTAPEEANNGMGSATTTSHPTTESPVMQIIPNPISMEVLSQSSTDGNLQCKTLGFDPDTWQPDFSQIIFPEDLKLQLENLTLTHDWSATVAQAKEAQQELQGLLSGIIQRSSVKIFRLEAYVRFLQQTVSLYRHAANLRAQIVPLTAGVQSRPIEITDDDIFGSFQKAALITLLVTDDPTSTSGIGSFTSSSSSEFDTFTLNAIEKILEHFEAIFLPSPDHNLKIPDIAEYLQGVKESLKGATGNVLQTSTWLVYSQSQYQGDLSTFDIQSCERQRKLKQFICNLCTNSDSASQQFGENFATYDIMISQYHQVLEQTAQTMSEVVHAYLESIRDSNGGVDPAPTTHASTSDVDHTTESPGLIPRPISLSALSASDLGACRSASFLGNNWELDVAGILPEVLREQAMNLTRDRGWAERVSTAKQSRQDLQALLGGIIEQSSDTLVRVEAYDRFLSQTLAMFEHVAELQAKLTHSTFTASEPIEDSVSQTFHKIALVAVILYHETTSYDAADNVYTTKSSEFDPFVVGAIDMLLGYDMEGRMPSGGHDADVEGRPDLGSFLKEIKNLQAGYLEGLMKMMARDDQSQYPGEDGSSSPFEVDTCKYSFRTQSNTCSICADLAIASYQYAHVFSTVDSYVTQYHDTLEMKAAEISEQVDAYLEANPTTGVDGGDGNPPQQHGPQCATTTYAPEWRVVTHADTLVSEPIQWLVGNFSEILSQSTQPIRESHEAMRKRTLLLDVFNTVLLYQSVDPVKVFVASSLVDNVMYSVTSTWMEVLKLATPSSDSIMTDGDAARSDPSMVTGGGSVMPPAGLVANFGIPASLFFLKPQTVERLQAIYSVELAEISESPALQLLEHLHSDYPDHLESYLYTLAQEVLSASDRHRMEDPKMSMIDKETRFLFEELFGHLQMREYLGMAFRAVDEMWQKMAQSGPSSTTDAQTPAHVTVECTRSSRFNPVPVNCSVCWKTEAETLMQEVNAAARPAMEELQAFLEQRSRRLMAYIMPAELVFKRISNHVSLSAVVGVFGVRDFLGELPRCGVWEAEFRRNGDYAIGEGRGSANAGDGRRGNGTSSPVGGTGDAGKDGPDGSGKATVTDGQGVTQQAPFGGDDGGGTVAPSGGGDTAGGDKGTGETSTPIPGGSGNGNPYKDASGDHSTQSPIDKVDNSTQASDAKDAKLQNSTLASPTQGQRDDKEGSSVGKTATQETVHRGDKGDSLDGTMPQVTAQNDGDGSNAGVTHHPPNRGEDGVNGGTEILAETEAPITDRNEGGGSNIGITYPPKDQQQDGTDSTGLEETVTRDGGRYPQDGNSLGGTEAPITDRNEGGGSNVGITYPPKDQQRDGTDSTGLEETVTRGGGQYPQDGNSFGRTEAPITVRNDEENGNHAGITYPKSPTDHAGPTTPSGDRNHQNGKDDPGIRKDGTTPSDDRVDDEVATTESSDGEGPHRGDGVTEDGGDGETPNEGGGVTREPDNGDGSPSKGDVTQEPGDGERPGTDGETPGVVDATREPVDGETPGPDGERPDGETPGVVKATQEPGDGETQRPGPDGERPDGETPGVVKATQEPGDGETRRPGPDGERPDGETPGVVKATQEPGDGETQRPGPDGERPDGETPGVVEATQEPGDRETRRPGPDGERPDGETPGVVDATQDPGDGDRPDPDGERPTVEIPKVVAIVSGPHEIPFCGSLLVRGSASVGPSLTYTWAITSSQGTSEALSARLKTINDNNYSDLKLAGELLTVGVMYTVTLTVSGGRAMPNTATHKVRKLPEAVMKPGLEIRHRRLGDNNVVLASKRVVLVADVQFYSSCIESSSVDFIWTVTGANGQNIPGIVPDVINRGGRNQRFWAHKLPVGQPITISVAIPPNGETVLVRTTTSITITVQRSDLVASIKGGNKVTVGRDAAEKLSLDASESYDPDNDEARLSYSWSCTGNGGESSDCTGLPSALDKPVLEVTPSSLSVGSYTFVVTVSRSQGEGEATARVMVEVDNGDPPQMKLRAPFMGMFKPSRRVVVNAGIRKAALVESVEWRVLGETVQGATTSIVKKPDTVTASFSLPAGVLSAGRDYTISATAKDSNGNTLTSGATTITIYKGVTGCELQLISTEYRVFEIIDINVVGCMGEGQLSYKAFVAPSADSKKRQVLTTSASDQSRLNQDRAVEVPDAATVAIIVKVCDETRSCQVVSQEGIAQVKEATEQGIQAVKNARMESVQKGDFVGAVHQNGMLVKYGPADSTGRRRRRGAYEEARDRHHAFFLNATSDFPNLDVSQWDSVAVDLDSFLVEEMEAKLDAVDNIQTMLTSYLELNPEEFDGDARDSILKKIGEVMMDLTPDTQESRDLIRRCRTMIRQITTHAGRGLAEGDSITTPTGRSTVHIKRLTLQASQAIQAGTTMLKFPPSLEHIGTSVTLNVEEYDDTEDFNSETSRTQPLSGPIRSITMQDENGVAYNVVDIPDPIEITFPQIDGKHICLYYDDGDKMWSKKGLTTKQARAGDAVTCQTSHLTDFAIAGDVNNGGVVDPNKGTIVPIAGLTVAAVAGIIVGVLALLVIVVLIVFMVLKVSKNKKVNPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRU3</accession>
    <name>A0A913ZRU3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038054119.1">
        <property type="nucleotide sequence ID" value="XM_038198191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198191.1">
        <property type="protein sequence ID" value="XP_038054119.1"/>
        <property type="gene ID" value="LOC119726483"/>
    </dbReference>
    <dbReference type="GeneID" id="119726483"/>
    <dbReference type="OMA" id="HRYHEKE"/>
    <dbReference type="OrthoDB" id="10066471at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206:SF1">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206">
        <property type="entry name" value="PROTEIN CBG10425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="30"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="764" mass="88824" checksum="61944568F43B6BB6" modified="2023-02-22" version="1">MVIKRTGSYMSLKTQKLKFLDITNYLAPGYSYAKFLKAYECPSAKGFFPYEYMTDLDKLHETELPPHAAFYSTLKDENISEDDYHYCQQIWRDKSMTTLRDFLMWYNNLDVVPFLDAIHKMFEFYKERQMDMFKSAISVPGLSLQYLFLTLPQPDVHFSLIDEANKDVYYAIKANIVGGPSIVFHRYHEKEKTFIRGGKLCQNIVGFDANALYLWSLMQDMPVGTFVRRKADQNFKPFQSQKWGVMAAEWMDWVAYTDGVYIQHKLNAKEKQVGDRQIPVDGFCKQNNTVYQFQGCFWHGHRCHLNKSEFNHVRKTSMDELRQQTEQTSAYIRQHGFQLKEMWECEWRQILSTEPGAKQFVESHRLPHHNRKTMNQREIINAVMDGSIFGLIECDIEVPEALRDDFAEMPPIFKNVDIDRADIGEHMRSYAEREGVMKTPRRSLIGSMFAKKILLATPLLQWYLNHGLEVLHIHEVIQYRPSACFKPFGEAVSDARRDGDSDPTKAIIADTMKLLGNSAYGKTVTNQEKHLQVKVCSSNEEATRLINNPNFRSLHTLDDELFEVELNKKSIRLGLPLQIGFCVYQYAKLRMLEFYYDFLLTFIDPSDFQLCEMDTDSAYLAISGESLDTIVKPELQEEFQREKGSWFPREDSAAHRAYDKRTPGLFKVEWEGDGIVALCSKTYYCFGTKDKVSCKGLNKRSNEITKRTYLDTLETQQAGGGVNRGIRMRQDGMYTYEQEKTAFSYLYPKRKVAEDGVSTTYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS10</accession>
    <name>A0A913ZS10_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053871.1">
        <property type="nucleotide sequence ID" value="XM_038197943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS10"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197943.1">
        <property type="protein sequence ID" value="XP_038053871.1"/>
        <property type="gene ID" value="LOC119726302"/>
    </dbReference>
    <dbReference type="GeneID" id="119726302"/>
    <dbReference type="OMA" id="YGWNGTI"/>
    <dbReference type="OrthoDB" id="6349241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="448" mass="48504" checksum="81BC392AF838E378" modified="2023-02-22" version="1">MDRQAVPPSPPHPWRWMIIVSRFFWTFICLGSFKSLGVLLPHFVDSFSTSTAVAGLVSSFLLGFGLLSFGPFVGALVKVWDSRKLTIAGGLLAGTTTVAASFSSSITQMGVLFALISIGLAFIQVSSVKPLMDYFPESFATANGVSLCGGTIGMMVIPPLVEYLVEEYGWRTAFALLGAFSFNYVVCGALLRPLHPMRTNYSRLPGQTYDADAATPELRNQFDDRLLPDRKKSRVNFKKVFSIILEVIRERFDTRALADPIFIIYQVACVLNGMLYSMWHLFLIPQGLELGFGDEPSAFLATYGGLGALIGRLGHGFLVDCGLIKASSLLALSSLVFSVCCGLNPLATSSYVAIAVLATVSGIAIGAIYPLCFVVMREITGDQQTSAYSWLFLSHGGGQLLGGFFGGWIHDVMGAYEFAFLGMGALAVVMVAMLVLTRCLMHFCGPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSH3</accession>
    <name>A0A913ZSH3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SET</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054040.1">
        <property type="nucleotide sequence ID" value="XM_038198112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054041.1">
        <property type="nucleotide sequence ID" value="XM_038198113.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054042.1">
        <property type="nucleotide sequence ID" value="XM_038198114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054043.1">
        <property type="nucleotide sequence ID" value="XM_038198115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198112.1">
        <property type="protein sequence ID" value="XP_038054040.1"/>
        <property type="gene ID" value="LOC119726450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198113.1">
        <property type="protein sequence ID" value="XP_038054041.1"/>
        <property type="gene ID" value="LOC119726450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198114.1">
        <property type="protein sequence ID" value="XP_038054042.1"/>
        <property type="gene ID" value="LOC119726450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198115.1">
        <property type="protein sequence ID" value="XP_038054043.1"/>
        <property type="gene ID" value="LOC119726450"/>
    </dbReference>
    <dbReference type="GeneID" id="119726450"/>
    <dbReference type="OMA" id="HIDRRNE"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000002">
        <property type="entry name" value="Testis-specific Y-encoded-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37111" checksum="37C6726A607096C6" modified="2023-02-22" version="1">MEGPTPSKQVKLTDSSANKEHDPPACLASASSSQPSSSSKTDSLEQESTLEVLEQIDICQGELENLNEEASEEIIQIEEKFNRLRQPHIDKRNEFIKQIPNFWICTFVNHPQIAPRLSEEDEECLHYLRQLVVRNYDDLKTGYSITFHFAKNPFFENETISKEFSLTEDGEPTSKSSEIHWKPGMDITKKLRSKGKMDVPCASFFGWFSDHLDAGNDEIADVLRDDLWSNPLQYYLIPDVDDSLDKSALMDSLMYSDDESNNVEVTPVIDPESRPITAKKDANDDSETAENHPALIKSNDKIQGTEDKLVENNVSTDDSKETVRDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSP2</accession>
    <name>A0A913ZSP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein ABHD14A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alpha/beta hydrolase domain-containing protein 14A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Possible role in granule neuron development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054101.1">
        <property type="nucleotide sequence ID" value="XM_038198173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198173.1">
        <property type="protein sequence ID" value="XP_038054101.1"/>
        <property type="gene ID" value="LOC119726471"/>
    </dbReference>
    <dbReference type="GeneID" id="119726471"/>
    <dbReference type="CTD" id="25864"/>
    <dbReference type="OMA" id="LEHVANW"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000093">
        <property type="entry name" value="protein ABHD14A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="31517" checksum="13BE686145AE0C8F" modified="2023-02-22" version="1">MAQATISPRGLIVLSLIVLGLIIFYRIYSEPDLPADDIIKEEQFIHLLQKESLGLLGMSDWEEIKKEALASKVLKVTDGKIDVGGKGAVYRREVVDTTRDMPKGVFLLLHGMKFKSQTWLDLGTLHVMASYGYRVVAVDLPGYGNTEKIEGVDHTAFMTELLKSINIKEPAGVIIVSPSMSGSYALPFLMAHQEKFAGYVPVAPVNTEKYTKELYQKIQVPTCIIYGDKDTMLGEVSLKNLRNLPTAEIHEIKEAGHACYLDQPLVFHKHLHAFAKQVFEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT54</accession>
    <name>A0A913ZT54_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054938.1">
        <property type="nucleotide sequence ID" value="XM_038199010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199010.1">
        <property type="protein sequence ID" value="XP_038054938.1"/>
        <property type="gene ID" value="LOC119727145"/>
    </dbReference>
    <dbReference type="GeneID" id="119727145"/>
    <dbReference type="OMA" id="MIDCGPL"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087627" evidence="14">
        <location>
            <begin position="33"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="17">
        <location>
            <begin position="143"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="455"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="515"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="636"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="696"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="757"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="950"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="698"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110174" checksum="3B05218E8C9E23DC" modified="2023-02-22" version="1">MNIIMHCIVHMELCLFVDCIFLLLCQVPPMKAQSPREGSVRLRRGINSQSGYVEIFHSGQWGRVCDTAWDHNDAHVVCKQQGYNGAKFPATDFTELPNPGLPLVLDNLQCTGRETALADCNKGEWGPVENGCQTARVECMSYAAQYIGCFADDTDRLLSDYSRLCAQGKHDPRCAGCDHTNTACDSSIMTVEICIEICCTDNDFVYAGVEAGDECYCGDAAADYNRIGRLPEVLCNTQCSGNPEQSCGSDYKIDVYDCSSGCEAPTVDKPNLKTFPTMLQTTLYKTGEMLTFYCTPGYQLSGNATISCQPGGPWSAPVPDCVETTSTEIPAVSDPCSYPTTTPQNGQYLPEEVEYQPGSTVQLSCNSGYLTAGNPTLTCQSDGTWTTENHACPAVDCGPLPAFQHAIPSTSLTTYETTVTFTCEAGYQLSGDVTGKTCDASGGWAGEDPQCAGGSTCGSPPFPSRGLLIPFKPLYQPDETVKFSCFAGFEVDGATNATCRNDGTWSDSVPTCQMIDCGPLPVYQFVTPVTTATVFATSVTFRCDDNYHFANGATPFKTCDADGQWVGIDPVCELTTCPPLAKYSKAIQSTDVTVVNTVVTFTCETGNELQDSEPIPTKTCTSEGVWEGPDPVCRMIDCGPLPVYPFVTPVTTQTVFETSVTFQCDDNYQFANGATPFKTCDADGQWVGTDPVCELSTCPPLAKYSKAIQSTDVTVVNTVVTFTCETGNELQDSEPIPTKTCTSEGVWEGPDPVCRLVNCGPLDEAPPGVVVNATDYTFNSAVTYSCNNSDQIILGNATLYCLSNGNWSSDLPTCANGTIFTTAGVSKGAESNPGTTIPFFIWIVLLLLVVCLILLIASYIVYRVHTRSYKKYKKENSDNGLPSRGTQGVPLHGIAISDPHHLVHDNYAMSQDEEGDTGVASNESDLQDVSLGSESNYRYLGNAYAESLHSGSVQPSGTNDSGMYPSDPESNSLGTDVAGGAGAAHGEQAGDDRDGDKHEVAEKKDKDFIDDMLDSAKEKLDNCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVB6</accession>
    <name>A0A913ZVB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055490.1">
        <property type="nucleotide sequence ID" value="XM_038199562.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055491.1">
        <property type="nucleotide sequence ID" value="XM_038199563.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055492.1">
        <property type="nucleotide sequence ID" value="XM_038199564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199562.1">
        <property type="protein sequence ID" value="XP_038055490.1"/>
        <property type="gene ID" value="LOC119727611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199563.1">
        <property type="protein sequence ID" value="XP_038055491.1"/>
        <property type="gene ID" value="LOC119727611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199564.1">
        <property type="protein sequence ID" value="XP_038055492.1"/>
        <property type="gene ID" value="LOC119727611"/>
    </dbReference>
    <dbReference type="GeneID" id="119727611"/>
    <dbReference type="OMA" id="RLIWFNR"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="310"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120977" checksum="940E0DD08B904CD5" modified="2023-02-22" version="1">MDESYPDYDDTYGGKPLKLRPLPSFDQNGTSEHKSKKRKKKRKDKKSPCKANTATQTIIPKRIDYILVYPKEDQSDFKDDDDIEDFKKRNELRRRFHHAAREQEGLEIRERDMGEKIYVLIHCPFSRMCHEAEDVNLEMPLEGAAIPKKEPSGCFDKLKALFITDNEVDFISAPFVVQKRAVFKGIDKPDTFFSPALRSLLVHNILINIDVREKGDKDSDFRDSMRRKARSRLRPGLSRGLPFMLMKKVYTDRFIMHEESPYELEEDDETREIQRTLSRERGDFDPTADPREALHRTWCRSWKFQPLWKIRNYFGEKIAFYFGWAGEMASLLWLPMLLGIAIWAYGLYLSVKDNIELNEGLADLAQQRDDLIAELRQNITLYNRTEDKLLYQNLTAEAQEEDSLFSGIADKSLEILEVFQTSFDSAVTPYFALVICLWGTIFQESWKRTHARLAYEWDVDTYHFSEPDRPEFYGTKEREDPVSDLPDWYYPFYKQFLKFMTSFGILIFMALLVIASVLGVIIYRVIIGALLADASSLQRVLLSTVAATLLNSISIMILGRVYDYIAYKLTDWENHRTQSQYDDALILKLFAFQFVNSYASLFYIAFFRGLTAKDGILYLGEKYEDSCGDENVCMPLLSLQVFVLMIVKPFPKFLKDVILPWLKKLLKKCCCGGKNKVADVEASKMEKSDFIRKEGSKPQLGNFTLGEFTEKTIQYGFLMLFSCALPLAPLIAILVLLVDIRVDARRMLWMNRRPIAFIAGGIGMWFSILDFLNFAGVVTNAFLIAFTAQWSKDFTTADRLWVVICFEHIVLSVKFFIAYIIPDTPSDITLAKRRQRYQIAQIMDKAETQGPIQSKEGANVVLAPDLKAFNYYDCAVKNTDSNPALNSVITDDTFLTAERKTSLDVEEKLGKLDDGAVGHTQDHSDTLAPKLSYGEDGTTYIGQPEKFPNETKKKKKKKLKKRNSDESPPQLDPAYPPATDDVALHNSGYQPPNQAQLYGLDGYQNDPALYSNNDHVQYTPQGQIADLAYPPQMPSRDMAYPPSTYNTQDNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW32</accession>
    <name>A0A913ZW32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055729.1">
        <property type="nucleotide sequence ID" value="XM_038199801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199801.1">
        <property type="protein sequence ID" value="XP_038055729.1"/>
        <property type="gene ID" value="LOC119727757"/>
    </dbReference>
    <dbReference type="GeneID" id="119727757"/>
    <dbReference type="OMA" id="HHRIRDK"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="287"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="781" mass="86972" checksum="7EF317D9B2D46239" modified="2023-02-22" version="1">MSHNDETDETSHSTVYSSSIPEDDILQTDFNETTQLLTDMKKKHRSIAHDGYNGNGISQNSFTVGYSADLVTPETKVASNNLPVYRRMWSSLSLSSQGDGDTKKSWMAKFKTKKAKHILNNLKIGLLLMLMLVVLVFFSLQEETEAIRTILPTSRTQSHVLNISDINEARLDVIRLGIAGAFVIDSDEAENPHNATVILARSSDGHVVKEYNFILDTDEDVVQSNQMVETIEKILLPWDDSHEDDTFYIKVSTDTEHHTVIAIRYLAMPYAAQYDVIYAGVILIAVYVLIGFDLVHRTVAAMLGSFAVLATLAALNERPPLETIMTWIDYETLSLLWGMMTLVAIFSETGFFDYCALKAYKMAKGKVWTLIIILCVFSGAISSVLDNVTTVLLLTPVTIRLCEVLELDPKYILIAEVMFSNIGGTATAIGDPPNVIIVSNKGIQEAGIDFAEFTLHMFIGIIFCMLAGFLLLWLQYRKMNLSAKDPPEIRELKREIELWRQAATRIMVATKEEATVKKLLMQKVYQLEDSLKHQMVMVGELESSSTWRENLKELQKKYRITDKNLLIKCSIVLIAAILTFFIQSIDSVHLNLGWTALLAATFLLVLADINDIENVMHRIEWATLVFFAALFVLMEGLTHLGLIDFIGSLVSALIKAVPKDGQLTVAIILLVWVSAIASSFIDNIPFTTAMVPIILSLGNDPNLDLPLKPLVWSLAFGACLGGNGTLIGASANVVCAGIAEQHGCSYNFREFMRVGFPMMLVTTFVAMCYLLIAHSWAGWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWN1</accession>
    <name>A0A913ZWN1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055715.1">
        <property type="nucleotide sequence ID" value="XM_038199787.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199787.1">
        <property type="protein sequence ID" value="XP_038055715.1"/>
        <property type="gene ID" value="LOC119727745"/>
    </dbReference>
    <dbReference type="GeneID" id="119727745"/>
    <dbReference type="OMA" id="SWYEEPT"/>
    <dbReference type="OrthoDB" id="10494951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1960"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2811"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2865"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3092"/>
            <end position="3133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3182"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3228"/>
            <end position="3269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1693"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1722"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1738"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1840"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1877"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1996"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2075"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2120"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2172"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2237"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2280"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2363"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2479"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2525"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2542"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2580"/>
            <end position="2593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2618"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2657"/>
            <end position="2673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2719"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2782"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2843"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2865"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2876"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2903"/>
            <end position="2934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2962"/>
            <end position="2971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3098"/>
            <end position="3108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3271" mass="364267" checksum="3BEAFF24F7BF8BF7" modified="2023-02-22" version="1">MFSPMTAARALYKTFVGPSEEEDEDGIKREDAGEKEDSGSDSDGGTSADPPGLQDFLKHTPAGDDTEVRLQESEIIASDTAAEVYTVRTEEFSARLSALPLGEIVDDDDEEVTTGDIIPGDGSGASKDSDGRVITLPEDIRTVINPAVKSAHDTVDGKDRTADYELPELDSEQDKNAQLNNDFGDRMLQQDNDSDGDIEQDQRKRNELELDSDSNSDTDSSSNTSDETMSTVRENTESCQLESEDRNEFGEGDDSCEENSESWPSEDEEHIYIAPDLEFPFYQTNVELEQTINVEELLENLDKKIVLEPPKPDKERYSPRPISNEELDNALKILRSGKPQQKRSWFSLDNVSSSKPNRSFALCYGERRNSAGDDNEPSSPEGNGIVFSLTGISKDKHRSHSADEHLGEMENYIPSELSVDDLVFPRPASAPKEFSLDPEEVTWRDDNPYTPSDEHFIMATPQSPPETIADDGPTKLRPVSPLDSNQFPTTNEDPAMPVAESAPYDHYNPFDKHREGEKSYIPNTPPHEDAAYPGQESNPEETPYQPEVSNPPYDGTYSPRAQADAIPETFASDDPPLPSPISPSSLNDDAALPDPQFAPEPITFATPSEPRSEPHPELVCQPPTELHSSSPSPTELPQEPTSEWALPSALKTTPNLHSNVHVKFASEFDENPKESNPVETPYQTDVKYPPHDGTYSPRAQADAIPETFASDDPPLPSPISPSSLNNDAALPDPQFAPEPITFATPSEPRSEPHPELVRQPPTELHSSSPSPTELPQEPTSDWALPSALKTTPNLRSDVHVKFASEFDENPKESNPVETPYQPDVKYPPYDGTYSPRAQPPRADAFPGPESIPETFASDDPPLPSPISPSSLNNDAALPDPQFAPEPITFATPSEPRSEPHPELVPQPPTELHSSSPSPTELPQEPTSDWALPSALKTTPNLHSDVHVKFASEIDENPEESNPVETPYQPDVKYPPYDGTYSPRAQPPRADAFPGPESIPETFASVDPPLPSQISPPGLTNDVPLRDSELAPESTFATPSEPRSKPHSELVDQPPTEWQSSSPPPRTPSPAPTSEWSQPSAAEATPLLVPNVDDGFPSKVDENPDEFPPPPPVDNDAYIPNDKFDDLPPPPDDISVPYDDDVNDEILEPEDSPMSPEPYISASIKHPKVFYPPSLQTHPQDVEHEQFPRQIKHEQRPVFSLKKKESAQSEIENILPVKKTYPTLPPKPNLQKQKAVTETPIRSSSVTEEKTPVDLSSLDSNQPDEVAPDESPMSPEPYISASVKLPTVFSMPQFESPVSSKAEPSYRGNIIEHEQFPVFSNVNRELAFAELENIVPKRKVPPQVPPKPRFRRQKIVEPDLVSTGVAEVECPIDFSRLDQKDQTNVITPDPEFVSEKPLPGTVEESYGTGETTTQDDVIIEAGISVYREESQEIYHVPGRQQPVTRAESLQMPDAGDLSYIPRDETTPPEDELPIQSQDGVENRSLDESTRETVRINARLSLHRMESGEQFTETVISIQEQEIKGEDQQSSSSDSEEDVSVFASTTGCNKDEDELFGSERYNDDGTFSTEDNYHPSAALPEAFESFPGASAPAVDSNSDHFESPEFSSADEFVAEADIAIRKMSAAMNAHHLKEITSSSSSSSDDSSASSDSDDSSYESAEEHTYIVTESGEGFEEEDDNQGYGVVSRPLPQVIEEGEEEEEEEEEEEEEEEEEEEEEEEEEEKYSHDAYVDDNQKNEEEIKEDEPIEDQEGEEQIEHEDERVEHMNTKNSDDEAPHEQHVTISLEATRDQPEELPDSEIPNVTPTEKPRYPKYINYDRPMYENKPGVGAEYDGSVEQIFDLPHKTAEDSPPLRKSPEMLETTIPGDEHEGSESSNESDTTEESSDHSEDNEEEEQEEEDEEGSDEREYREQTMDFSSEYSDEPEWLPPPPSTGARVFVLTSNMPYPVKVEPRPAPVVLRQHHREDDPQFYEPRYTDTSSIHSEQNADETKGGTVGDVMRKGDDEDYNKSEEVFESDQYFRPITEVAPSASKSNLEETARPIPQYTTEETHDSPQSVTSAPENAPEVSRDSIAPGEQKSNAQDVKSVTITYTVIHTKPLQDGTRDVDGNTSSDSLPQDAPTSDDRQHPKDEEMEDRGVTDKSIPQSNSYQRVLKDEDFPEYASDPPYRGGPPSNGFTESPTEYSETIQPVNAAVVESSPPSGPREPSIKQRVGDSLPPYETDLDKYEFAYRSSAATEPEVEREPEASSEYRPDVAPDESWKHSSKSIPVNEVGPYNYTSHPDQPRENRHDSRETTVKKIELRPEVSLFTISPREQSIPHKKPTSPDAAASSLAGDTGDTGPYRYSSWYEEPKDDTPAMAIALVKSDIRLPPEYISERKTAEKPKPKPKPEGRPRGPGERLEDGEYSGIRVMWYDEPSEEKPNESDDVIIISSVEPQEESQPKEETPLSPEVEPGTYKYSAWYEEPSEEPTGDNYFAVSRPAAEEDKSKSDSARAPVSPEKGPGRYKFSAWYDEPPEEPSKEDYFVLSSPSANEDTSKPASSSTRNREEIFKEGLSRSALYEHYQSQKPATEDPSATFVISRPYEEVLRPQDEGIRSTKSTADDLYYPQEAGIDRNVKEPSGNSLSVEGNVSGTSSRNNSYGSSRTSGSLADVSATSGEAMRRTWSDDSDEFRNGKDSTVFEPPAVQRVTKLPPQPKPRKGKPSAPSSSDDEQQTQQPRRPGRSDRRVPEAKPDLGQNLSPRDEYALASSSWRQIPVEEPRPPQESAIWDSGDDRLGRMRPGNRGVHDNRYSVPEKPRKEIEQMLDSLVDDEDAFDRPQTHGRVPQLPPQRLDDAPAMGRWRNDGTRSMNLLPQTQSKSYEFVETSFQESRFQSTSESHIPRGFDEKEARGRHPDFAQPITVLRPRGNEPSRMPETRPDNKRLPEGRGRQPVPRDDGNDGPPSSRDEYRLAAASWENMSSASDEGPFKRTKMETWDNDPDAGPTQTAYPAALISKQSHQPERAPGFSEEAYAPPRGPRGKGNGMVVTADVHVPYVPPPVPGDPQLAVQMLSVSSSTAELAPPPPTDWGTPRKAYSTLAISQLVPRQPNMEVIIPDAEASVPRRHHRSKGRGLHPPPSGPRSGRPHSPVSIASYSSTQSLPARILPRLPRDNELEKLKQHIAEIGKLTEIKSAELRKLYRRNPSVRHHIPMRGPRGELISPDGRVLSTPEKPNRAELEKYKRFFDKLPEPHFRRLMHEMLEYKHMVKQKEEEIRRLNTQCVGLRKRLAQLAQQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXQ5</accession>
    <name>A0A913ZXQ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056095.1">
        <property type="nucleotide sequence ID" value="XM_038200167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200167.1">
        <property type="protein sequence ID" value="XP_038056095.1"/>
        <property type="gene ID" value="LOC119728094"/>
    </dbReference>
    <dbReference type="GeneID" id="119728094"/>
    <dbReference type="OMA" id="PASHIWD"/>
    <dbReference type="OrthoDB" id="6369810at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037481004" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="19784" checksum="084764BA69292C03" modified="2023-02-22" version="1">MYLFKVFGIVAITSVSNAQLGSSPCLSRLTVECSCPPQWQLWGKACYRLTPASHIWDDAKSACRDLDGKMAAPQSLEEMNFMTEMAPKVDNRFSVWIACNDKEEEGTWECDNQEGREPLVWDDGQPNNNYGDQNCARMASVHHDRMDDYGCDYRFTAFCVRRAACTHGLTQLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A395</accession>
    <name>A0A914A395_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038057846.1">
        <property type="nucleotide sequence ID" value="XM_038201918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A395"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201918.1">
        <property type="protein sequence ID" value="XP_038057846.1"/>
        <property type="gene ID" value="LOC119729300"/>
    </dbReference>
    <dbReference type="GeneID" id="119729300"/>
    <dbReference type="OMA" id="QVEIGYR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05034">
        <property type="entry name" value="PTKc_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="303"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="575" mass="64307" checksum="91B611B6BA33DF1F" modified="2023-02-22" version="1">MGNKESSHSNGLDGPDGYDHSTSTITVSSAKLGRDRKDRKDKDKKPKKGKARKDSVNAATSSGAGIGSSGAGGDQDRQNHVGGDVGGGGAGSVGVMISAGVGNDQMGIMHSPSTRPAGERYKALYDYEARTADDLTFRKGEILIITNKTDPNWWLATSMLTKREGYVPRNYIEPADVLQAEDWFFEKMTRKEAEKQLQLAGNSRGTFLIRGSETSPGSAYSLSVLDHDDARGFNVKHYRIRTLDNGGYYISTRITFHTLHDLVNHYTSQADGLVCRLLNPCPRQKPVMFEISKDVWEIPRRSIKLERKLGNGQFGEVWEGALLERAEEHSRTWNGTVRVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAVCSEGEPIYIVTELMTNGCLLDYLHEGEGKQLREPELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIEDEYIAKEGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGYRMPKPPECPDQLYDITKQCWDAVPEKRPTFEFLHSFLDDFYHASEIQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4C3</accession>
    <name>A0A914A4C3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Diacylglycerol kinase</fullName>
            <shortName evidence="11">DAG kinase</shortName>
            <ecNumber evidence="11">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038058540.1">
        <property type="nucleotide sequence ID" value="XM_038202612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4C3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202612.1">
        <property type="protein sequence ID" value="XP_038058540.1"/>
        <property type="gene ID" value="LOC119729823"/>
    </dbReference>
    <dbReference type="GeneID" id="119729823"/>
    <dbReference type="CTD" id="1607"/>
    <dbReference type="OMA" id="HNGKSDH"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20851">
        <property type="entry name" value="C1_DGK_typeI_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20845">
        <property type="entry name" value="C1_DGKbeta_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000013">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000016">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047471">
        <property type="entry name" value="C1_DGKbeta-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="14">
        <location>
            <begin position="648"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114045" checksum="548052BBEE6B3C38" modified="2023-02-22" version="1">MPPVNAQSRVSSRLSLPSWCRARRQRCGNGYNLMMTAQGIINRPLFVPCTSALVMALKDQAQSVVDMVMVDSRKTLKDVLEEFHGNGVLSKYNPEQPINYEGFKLFMETYLDVDMPEDLCRHLFLSFVKKTPMVTAHHDVGLKGKESAQLDVTSMMAAATTQTACAPICTGAGSATSVQKSGAPATAATTSPPAQTTTTTTTTITSTEQGRGAADNASPAQSRSSSKKSNASNGTPSSHSTTHALQAQAESPKSETTVTSNGRKKKDKELNKRGRFFLSLRKKRKKRMRTKSSGQEDGGPQMGGGMGGGTSYPDVEDQVVYMKDIVCYLSLLEGGKPEDKLEFMFRLYDTDDNGILDSSELDCIVNQMMHVAEYLGWDVTELRPILQDMMIEIDYDSDGTVSLEEWIRGGMTTIPLLVLLGLDTNVKDDGNHVWRLKHFNKPAYCNLCLNMLVGLGKQGLTCTFCRYTVHERCVQRAPASCISTYVKSKRTSNTATARQQCLSKRDAEVWGEVPVMNHHWVEGNCHGKCDRCKKSIKSYGVTGLHCRWCKIMLHNKCASLVKPECNMGEFRDHILPPTAICPAVLGRVNSVRKSTHGKSASANIEERRSTLTPKDSNTSEDVEGPRKLVTRTDSMSMEGQGLQITPLPGSHPLVVFINPKSGGRQGERIMRKFQYLLNPRQVYDLSKGGPMPGMKFFKDVKNFRVLCCGGDGTVGWVLDCIDKLGFDPRPPVAILPLGTGNDLARCLNWGGGYDGGSLTRTLHDMQSAENTFLDRWHIEFSTTSTDEQGDPVPYNIINNYFSIGVDASIAHRFHTMREKHPERFNSRMKNKLWYFEFGTSETFAATCKNLHEDIDIMCDGVSLDLANGPSLEGIAVLNIPSIYGGSNLWGDTPSGKKRKRLAKKAQKRRESEGHSAVGATHDMDLTFAKQSIGDKLIEVIGLESALHAGQVKAGIRSSGRRLAQCSTVTIRILKRFPMQIDGEPWLQPPCTIAITHKNSTPMLIGPPPKKSFPGLRNLFSRPSISEEDPSDIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4N1</accession>
    <name>A0A914A4N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058665.1">
        <property type="nucleotide sequence ID" value="XM_038202737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202737.1">
        <property type="protein sequence ID" value="XP_038058665.1"/>
        <property type="gene ID" value="LOC119729947"/>
    </dbReference>
    <dbReference type="GeneID" id="119729947"/>
    <dbReference type="OMA" id="KMDGNRS"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12338">
        <property type="entry name" value="RRM1_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000053">
        <property type="entry name" value="Serine/arginine-rich splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="252" mass="28589" checksum="AC2CBE32CD6634E6" modified="2023-02-22" version="1">MAYYGRGGGGGSRHSDTPTDGRIYVGNLPPDIRERDIEDLFFKYGRILHIDLKMPKVGPPFAFVEFDDKRDAEDAIHFRNGYDYDRYTLRVECPRSSGARGSFSGGSSGGGGGRRGGPPPRRSKYRCIVSGLPSTGSWQDLKDHMREAGDVCYADVHRDCTGVVEYVTEDDMRYACKTLDDSKFCSHEGDTCYIRVKADYKGGRSRSRSRSPRRYSPKRSPRRSSYSPKRSRRSYSRSRSRSRGRDSRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A655</accession>
    <name>A0A914A655_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058886.1">
        <property type="nucleotide sequence ID" value="XM_038202958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A655"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202958.1">
        <property type="protein sequence ID" value="XP_038058886.1"/>
        <property type="gene ID" value="LOC119730173"/>
    </dbReference>
    <dbReference type="GeneID" id="119730173"/>
    <dbReference type="OMA" id="WYNEGRP"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="60"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="196" mass="22171" checksum="D39AA233FCE52D3E" modified="2023-02-22" version="1">MSHTRDSHAQSTSLALRTTIQGIRMKFPTVKLVTTSTLQKWMDGVENTDMPDSAASTAGKHSKLIVIDARPDLEYGISHIAKSINVNFETEDMESVKILMMQEANCQSPEQVAARVVLYCSVGYRSSVLADKLQKATKPDPAYKYWNFFNLEGSIFKWANENKPLVDQQGQPTNYIHPFNSLWGKLVDKERWKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8H6</accession>
    <name>A0A914A8H6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060068.1">
        <property type="nucleotide sequence ID" value="XM_038204140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8H6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204140.1">
        <property type="protein sequence ID" value="XP_038060068.1"/>
        <property type="gene ID" value="LOC119731123"/>
    </dbReference>
    <dbReference type="GeneID" id="119731123"/>
    <dbReference type="OMA" id="KYDQTAS"/>
    <dbReference type="OrthoDB" id="8192811at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017893">
        <property type="entry name" value="DBB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041340">
        <property type="entry name" value="PIK3AP1_TIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF11">
        <property type="entry name" value="STUMPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14545">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18567">
        <property type="entry name" value="TIR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01282">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51376">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBB" evidence="3">
        <location>
            <begin position="236"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="972" mass="107755" checksum="4E809D17C5BB422B" modified="2023-02-22" version="1">MESSFDPFDLTILYTEDTIQWCEYLFDIFKDFEIQQNSEDITEFPTNHRTLQSIQDSLVTVVIISPLFLQKCNPRMQEHIHQAVGLICGIDDADMEELYQKMPSSRDWYQVEAVAGSAEISKVVLKVLHDANDVKERHRQGEIEDTYIEVNDGVEGFIQSDYMVMENLGGKPKVIGGPENTYFVPDQPDMPEETYESMMAIQAPVGSGHVFQPSSQGYVDMKEAKHLSQCSAGLTIHPERARSGEEGSLYILLNDPLANDQYTVSFQGQLKKSEVIAKQKNTYTLQVDLPKDHPAELTDVQVTRTNRAVVGTFKFIFTSIMDELAQTLQGIVDPMRFMCQALGISTADANELDNKLYEHIQTCLPSGGLNLLVGQSGAEQKVITEVPTALHFAAKYGLKNICSMLITCPGAVQAMKLKNRDGLTPDIMAGMSGHSDLKSFLENFVEVAEDESIPGVGGNPSSYMFMKTGLIYLNQTAVQSQLSKEQASDYDSPFIVPIPAKGVPFTREETIKKLVQGEQEDIEEYYGSLAIDMSSFERDQDGEEDYEKVEDESGLRKRSTKRSHLKQRAPWQQTEEKPSATEMVLPPPVEPRLAPPPSEQEGEAPEKPPPRKNVKAEDILGLQPLATGQQHLIEIQNRVKNSEVTVDEAVMLFKNWELLQEKDRLSFSAQVETLKVLKQHKQKAKQTGGPRGFFTKKKKGGPVGEHIGQSIFYSPGSPVVKVAGLVATCSQALGFLNKPTRKGRAQSEPLISSCYAPQPAPPVSLKFQERMIQSEISVQNRPTSTTSLDSHGSRDSSYNSAPDEPDQEKYHSSPASTTPASRRQTQQDRNKRISAAYDQLSNVPEKSMPPVPSRSTAPKPGVPPCTLPMIPKPSPPYGHYQPSPSPSPGEEDQPDYMEFDEEPIPGDLPGLPPPPPPTEMGAERALDVKTPVSPTQSSRYSESPLSASKYPQVTPRQPAQKRPIPKPRLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A908</accession>
    <name>A0A914A908_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060327.1">
        <property type="nucleotide sequence ID" value="XM_038204399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A908"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204399.1">
        <property type="protein sequence ID" value="XP_038060327.1"/>
        <property type="gene ID" value="LOC119731266"/>
    </dbReference>
    <dbReference type="GeneID" id="119731266"/>
    <dbReference type="OrthoDB" id="10059338at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="822" mass="92362" checksum="8D31FF54ADBFFA8C" modified="2023-02-22" version="1">MHSNSSVGEPQQSHIVHGPHCLEKDVQAADQTPLKSSLDESQKSHIIVQRHAPSYPVEDNLDSPDEYSSDENDPDFIPDSNSSDEDIVPESSDETSLRSPSPVIPIPSRESSNHPVSSDETVSSTSEIEVMTTSNSEGKRHWDKPQYCPFCLQQQKKLPRHLTTPMHKDETQVKTWLATTDVKEKKKQLTLMRNYGNFLHNSTVLKKGKGTLIVVYRPGYDTDHNDYLPCQDCYGYYAKSDLWKHRCSQKPDVDCSGEPCVKKRRTMFCKPGRMLLPSTPGVSARTNEILSSMNADNISRLVKSDELIKRFADKLVMKHGHSKDQAGYIRQRLREIARMVLEFRFLTGQTNVGLSTLICPTKFVAVTRATRVAAGFNDETHLYSTPSLALKIGHSMKTCAEILRGEALMSGDESTEKRCKGFLSLYSTQWEEKVSHHALRSLNEAQRNNPKLLPLTEDVVKLSQYLKDEVRVREQVLQSADGSREVQTAWSRLAEILLSQIILFNRKRPGEVSRMTIQDYSKCMNGEDTIIEGALTAWEKALCRVLWRVELIGKRSRTVVVLLTSDMKHALDLLLSKRAAAAINDGNDYLFSARYGEGHIRGTDTVREHANKCGAKQPANLRATRLRKHIATVSQIMNLKENELDVLANFLGHDIRTHRQYYRLPQSTIQVAKVSKVLLKMEKGDIRGLAGKSLQEVELNPDEDYNTDAESDAESGSDAESGSDAESDAEAEVNQVKPPANGDRHGKGKQPTIKRAWSSKEKKAVARHLGGYLRGRTVPGKAAIIKLFQAETGTFSHRSWKNVKDFVRNQTRKQDPMSFLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9D7</accession>
    <name>A0A914A9D7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060039.1">
        <property type="nucleotide sequence ID" value="XM_038204111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9D7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204111.1">
        <property type="protein sequence ID" value="XP_038060039.1"/>
        <property type="gene ID" value="LOC119731096"/>
    </dbReference>
    <dbReference type="GeneID" id="119731096"/>
    <dbReference type="OMA" id="GTVMYNH"/>
    <dbReference type="OrthoDB" id="10382753at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="51234" checksum="BEB227DF5382D9B6" modified="2023-02-22" version="1">MKKFRQLIRECGEGTVMYNHLHMNLLKAGLVRTRGMGTAGRSRSRGRGRGRGRGRARQLYAAAAAAVPSVNCPLPDRTDQHNPSRDSHEVNDVIRHSQAPQGPVDLVKRNDFPQETSENYFLNLSQKRRDGHEMNIQFEPIKSQQIGLQDSVNNPLNLATQRGCSFVAPRREINSCNPARKSPVFRPFQNEMPSTVTHQVFQNDPRSRDVVSFSPGPSRSSPRPATNVGIAFVKEIVDCIFPELIYRPLAAEGREYLEVTPREATLLPGPVSSNQGAYGTPILCPCHPARILVSPEGRVEFQAAFKTLNTVHALLTSGGGGDSTAWRKSVLECVHSLTTQAGYRFCPGLGQAVPSVRCDDLMTSDFGLGFRSASCELWYRPQPRDVTAEVVNPSTSTHPLEGANGASSPTTHGLKGGFGDEESVESTALFMSDELGACAQCLDAFRQRNLRDGRRKQRNPRQMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA52</accession>
    <name>A0A914AA52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060735.1">
        <property type="nucleotide sequence ID" value="XM_038204807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204807.1">
        <property type="protein sequence ID" value="XP_038060735.1"/>
        <property type="gene ID" value="LOC119731610"/>
    </dbReference>
    <dbReference type="GeneID" id="119731610"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036872402" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="523" mass="59183" checksum="1656791CF4E8463F" modified="2023-02-22" version="1">MMESHRSSCLLTFVLALSTVSHCHQNATKPPNIIFILADDYGFHDVGYHGSAIKTPWLDKLAAEGVKLENYYVQPICTPTRSQLMSGRYQIHTGLEHWIIWDVQPNCLPLEDVTVADKLKELGYATHAVGKWHLGFYKKDCWPTRRGFDTFFGYYTGSEDYFTHSRGCGMPGFNCSGFKSGLDFRDQELPMHNYTGSYSTHVFAQRAQQILENHNPKEPFFLYLPFQAVHSPLQVPEKYIEPYKHIADKHRRIYSGMVACMDEAIGNITQTATQLGLWDNTVLIFSTDNGGQILHGGNNWPLRGWKRSLWEGGMHGVGFIHSPLLQDTIQGTVNSELIHVTDWFPTLVAGIAGGNVSGLSLDGYNVWGSISQGKASPRKEILHNIDPIPYPRLDQHGDFYPDPYFSYHSNLPSSFNTTIRAAIRVGDWKLLTGDPGNSSWIPPPDSGIIPIHPVEQKGKHVWLFNIQEDPNEYHDLSEARPDKVKELVGRLQYYYNSLVPPFYPPGDPRANPALHGDIWTNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAA8</accession>
    <name>A0A914AAA8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sacsin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060324.1">
        <property type="nucleotide sequence ID" value="XM_038204396.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204396.1">
        <property type="protein sequence ID" value="XP_038060324.1"/>
        <property type="gene ID" value="LOC119731263"/>
    </dbReference>
    <dbReference type="GeneID" id="119731263"/>
    <dbReference type="OMA" id="MCTRGHS"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="4">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="4">
        <location>
            <begin position="1355"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="4">
        <location>
            <begin position="2393"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="domain" description="HEPN" evidence="3">
        <location>
            <begin position="4235"/>
            <end position="4363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4172"/>
            <end position="4192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4204"/>
            <end position="4229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3833"/>
            <end position="3860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4174"/>
            <end position="4188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4204"/>
            <end position="4219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4370" mass="495839" checksum="3687E7B7606BC2E2" modified="2023-02-22" version="1">[encoded data, 4370 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABY7</accession>
    <name>A0A914ABY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061362.1">
        <property type="nucleotide sequence ID" value="XM_038205434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205434.1">
        <property type="protein sequence ID" value="XP_038061362.1"/>
        <property type="gene ID" value="LOC119732064"/>
    </dbReference>
    <dbReference type="GeneID" id="119732064"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="83"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="402" mass="44720" checksum="463CF6CF254FB36F" modified="2023-02-22" version="1">MRQGSESQSIKSCSMAYPTNVTIQPHTTFHPNSTLPDSTLHPNFTLHPNSTVQPRVVESIYTYPELVFCAVGLSILIVGTFFGNSLVLVAVARTRKLRNVTNVFVVNLSVSHVLLSFAVLWSVPAMVSETPGYPLQSDVPCVAAAVLMFIAWGTCVFTLANIALNRCILITRPKETYQWLYTPRKIALMVLGSWLVPLCTTVVPPLSGVGDLGFDPESRTCSHIVTHPEDVTYDNIQFALYYPLPAAVVLVSYVLIWKHVKKHFRKYQQHMCERLQSSTVVQTAPSSISMLGIDDSTSRRTRNQQASLRRTGSFRQLTSSKHDQLAITKNLFVVVLAFVVCFSPLAIMAVTKSQRYQLYGALILFLSGCINPLIYAAKHPLFAPVLRAMIRCRCSNDQHAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACQ3</accession>
    <name>A0A914ACQ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061700.1">
        <property type="nucleotide sequence ID" value="XM_038205772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACQ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205772.1">
        <property type="protein sequence ID" value="XP_038061700.1"/>
        <property type="gene ID" value="LOC119732281"/>
    </dbReference>
    <dbReference type="GeneID" id="119732281"/>
    <dbReference type="OMA" id="RIELTEC"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="98"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="246" mass="27529" checksum="1C9ABBD91F75AFD8" modified="2023-02-22" version="1">TVMVSCHQVCFIGSEYNPQSGIPPRWFLPYQDPCECTAIRLGGVGIPASSYRQGAPRYLDELFLSEDSNEIQAYFDCEPAEHNTGKKHVWTVYMVSQCSSPQPLGMENGTIQDDRITASSSRYRCPSGDARLNNENRWKPLNDTNSWIEVDLVESTVVTGVITQGSGRKWYVTAYKVAYKKQPSSDFEHVTDGNGNIKVFIGNTDKHTPVTNLFDESVVATVVRIELTECKTSCALRLELLGCRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFR4</accession>
    <name>A0A914AFR4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062346.1">
        <property type="nucleotide sequence ID" value="XM_038206418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206418.1">
        <property type="protein sequence ID" value="XP_038062346.1"/>
        <property type="gene ID" value="LOC119732815"/>
    </dbReference>
    <dbReference type="GeneID" id="119732815"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="112" mass="12037" checksum="27479E3FDBEECDD6" modified="2023-02-22" version="1">MSSLVTMATEQPQAPPPAAIGRDRRLPIPISNERSPGQRKTPVSFVVVPVSDLGYPVGSPGSSIWAYTPGSSGDWIPSSNLEDIPGTAANRMPNFPIKTLSLREPNLALFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH85</accession>
    <name>A0A914AH85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062886.1">
        <property type="nucleotide sequence ID" value="XM_038206958.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206958.1">
        <property type="protein sequence ID" value="XP_038062886.1"/>
        <property type="gene ID" value="LOC119733372"/>
    </dbReference>
    <dbReference type="GeneID" id="119733372"/>
    <dbReference type="OMA" id="HANTMRR"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18910">
        <property type="entry name" value="bHLHzip_USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048064">
        <property type="entry name" value="USF3_bHLH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1938"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1997"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1733"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1857"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1938"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1997"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2084"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2097"/>
            <end position="2136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2318" mass="248664" checksum="1887C7D7B0CB5066" modified="2023-02-22" version="1">MDADDIQGHHIDENEVNRRTELITNAAEKYLNGEVTESDNATTVDTVMTQQLLTTTPLEMGLQMHNINPGVAQDRKKRDSHNEIERRRKCKINIGIIKLGDIIPICQTTKMSKNQILEQACLYIDELREKSEKLLLANTSDPEAAEEIKKLRKENEKLRSENKRYQEIIQDMETHPNGAVEQPKSRSRSRKSDSSSSSASSKMAAMQSKPHLTYLPGGPNQVTVAVQGGNQMQSHVVGGGPTTLVGNVQGTQGGMAILQPNPNGAGYILVPAVSKYQSTTVTNQSSVVVTMSGNQQATPSGMVLANQPPQSMAGSQIAVDASATVSQAQTTTGQQQQANISSTQLSTSISDTPTAQSTVVTQAVNTPITTPGNQSTVVLQGGNVQAPGQVQTVRYIVPLVPGAGQASTSQTANQAIMLTLPVRQGQNLPVRIAPSSAAPATRSSQPMILPQPASGGSSVNAQIMQGVDSTPKSKKKSSSKVKNISETETESSRTGSPSVSQTGGQQVNIATPPPGGVTVRLPVAGGGADPGNVIVNQQGQHIMVQKPGQGSAQNVIMPMQISRPVMTQNLVYIQQNGQLIPVILQQQSNPAAVPSGAQTMMQPLQPQQQPQGVNQNFVTMPLSQGNRVLQTNAGGQIIMSGPGFQNALPINAQQGTASNQSGVSLTQHQATPSNLQAGQGEDTSQQGAVLASQGLLVPKQEPMPIQEGNGLGEDSSMLAPLNILTSGQESSDRGQEDMGDYSNDRDNDILAKAAESIFSPNSLSENSPMMNFGDMPGQGPDIKPNIAPQQTISAGGIVTLQSGIQLGRDLPNTFATPLQEVAPPTEEAMETSHRHEKHKSKKKKKKKNKEKDKDKDKEKKKHHHHHHSHSKTTISTDDATPAKSDVSMEGSPIERANMIAESLLQSWMEKTDGTDEKETEAQASAALSSNFSTEALIAGSTSNLPTVSNASSVAVCGSSESTPTNSNNAFTSFPSFSFGSDILSSSMSVSGLPTYIEEEEADYSKNDNEVNSLKALTSLRDSLSTGQPVATSQEGVDSVSSLVPEQTMATSTSNQPGIVSDVPVASSASGFMLDSPTVSQASVTTSDGSGPGFISPIPSIFSLNSSIPESGIQKPESGTSTPVINENEQDPISTQVAHQSGWISHHSKASELARGLQPARSQNQPPSTSGTGAIQLPVTSQTSDTSINQPGSSGLFSPMWLSPSSNMGSKTTSTPQTPSQESPPLHFGRDMSDVASFPTNEAMQNITEATSNLPHDQPPLMDLNKTVLPRHDGLRGLQASSTSESQSPQRPSILDVTPATSGLGNLESPHSSGTIAWHHTSIDRRHKVDSPVGICTRTPEFQNPLQIESRMTPEQNLLQDTLDQGNIRHGSNMRSEISSSQSREGSIENIGLQNLMSLAESTARTSVESSNLMSTPVTSSSGRPIDNSAGKKNQTGKTFSIKTLHRTLTSEITESPKKPSSPTPAVEPPSKVKTAEKTIPPLKIKIPKGKRRSSCQKEQSEQQPDKSETGKVAKVPSTSDMDQIGKRELNPNLIDKYPWLAEGEEDDSNQASAGDFNQSREKHSFSVQNISQSSQRSGRKDSGLVMTFQRKDNKQSAKEKPKTNVDSAPSTTVASSPSIAQVHSLWNPSNNDGYNRPSISKPESCNMPSVYSSRHSDTIASNRSTANLSSSLPVQHSPQVDSQSTDMSPFSVPINRDPNPAVVEKSKAKKPSRRGSNSSSHSIRSSSEPDCSPMQSCISEHSSPSGFHDLQSHNMPSDPQQTQTLQTSNLRNPSQSPVMNLAHQQQQQQQQGSNMHDAKRYAFQQNQGQMFLHNEESRSTSGQPSNSFQNFLQPARGSDFLGQATDPPDPMDFNLNMFDNQKSGSSDPTVMNSSSESRPDSRILPGRQVHSQPVYISQSEMAQVSDPSHDIHNKSAVYTQSNMDHSARFGVSQSQTMHVQQHGQALKRMSNTPTQPSNPAKRANIHHNHHGLSHMQGQDQRQPNVSLDPHHVVSAADTRTSAHQMHQPMVSSHANTMRRTSQNERTLTSAVQSQRQTYETSQSTSRFPEVSKGRKRAQNSEQFFHGLGQGQGIDNSLRHRDSSSQDQNWPGFSTQRSSDSSEPFLPLFSSSSMTQSQNTPASTTTSSSIVASLSPSRRLRGNELPTYLPHLPGPILPSPSQSNKPHQNRNDSDISAPYNAMFGPGRPGSIPMNVGPNFPVFTEHQAPHSFNVSKTAQISGGVSVPPPPFNFNLFNDQHSQPSHVNDPPLGLPTMHLHSNPALPMDDGMASLRGNVGSRHPQSFGNNMGLLSQGATPDGRPFKVGMPMGPHFHSTFGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHD7</accession>
    <name>A0A914AHD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062941.1">
        <property type="nucleotide sequence ID" value="XM_038207013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207013.1">
        <property type="protein sequence ID" value="XP_038062941.1"/>
        <property type="gene ID" value="LOC119733450"/>
    </dbReference>
    <dbReference type="GeneID" id="119733450"/>
    <dbReference type="OrthoDB" id="4207253at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="614" mass="69293" checksum="9E630D34AE4D2971" modified="2023-02-22" version="1">MQQSSCILDAIFDQILARNTKLTKHAVKVFIDDHESGIALLLDGLDEIPSHVLHSKGGVYRVQDILHSKVLAKSFVLVTTRPHMTEYVLSDDHQYAVVETVGFTPQDRDRYIRLNFPDDADMGDKLISNLKVNANLQEMAVVPIISQMLCLVWENQQSLPERITELYAEFALALFKRRNKDMSGKQVMSNMMSIIDGLGRVALQGLLDSSGERLMFDETEFQDCQSCLREGCRVGFVQLEQYTSGLHVNVLVTFPHKTIQEYFAACHLVKLLQDDVKKFRHQLKQIGEHNVHAMGYLLRFCCGRSGQAAGLILDHIKNVQSERLDFEKKPQMLARWLLLESGSGELAAKLVRPNMVHCNSNEDLKSLNYYLQHVTPPLKCRHFYMDVRQQELTFLKGILLSDSIKSADKVVVNYHLSEQQQGGKELSLLEKTLGVVDEQHRALLDVTIHIVRESWFDLGPISHSFFRMQKQTGSLSLSMVTRSPDEFFYLLNALEGCRLSSLTLWDIDLHARLRNVSHISSSLVSLNLSGCGLVDDDVKDLMRILPAGHDLSMLVLDNNAFSSNAVSALTHHLRRLPNIGLLPSADERGGLRRTRGLTKSEGLLLSWGIPLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHH1</accession>
    <name>A0A914AHH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063172.1">
        <property type="nucleotide sequence ID" value="XM_038207244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHH1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207244.1">
        <property type="protein sequence ID" value="XP_038063172.1"/>
        <property type="gene ID" value="LOC119733881"/>
    </dbReference>
    <dbReference type="GeneID" id="119733881"/>
    <dbReference type="OMA" id="VWCLANT"/>
    <dbReference type="OrthoDB" id="6155932at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="314" mass="34374" checksum="230B80E10EB79382" modified="2023-02-22" version="1">MDAVVDGQLSSASSSSEPPSSLSENVEQLPLLDKERYVNKLGNIGTCNPYLIPASCCTPLLKSNLLPKLEFPDIYKYLINFPSSYTGEAMKAYKSLDGYKYFIAGKVNHLLVWHQPMKRDPTTSVFVILSKVHHSQRLNDPPVKVWVAIQEDGVVITAHCTCMAGVTEVCSHVAATLFAVSKGVEMSTTTCTSKPCTWIKPAKSRSSGDDMYAEASNINFSKPKRRMTETPTTLPKSSCKSRSVPPPSKDETDNFFQQLKGTGVPSAILSLVPAYAADFIPKALQLKLPEPLTKLYCAENLKVSYPQLLTKCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHM1</accession>
    <name>A0A914AHM1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyltranspeptidase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063495.1">
        <property type="nucleotide sequence ID" value="XM_038207567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207567.1">
        <property type="protein sequence ID" value="XP_038063495.1"/>
        <property type="gene ID" value="LOC119734206"/>
    </dbReference>
    <dbReference type="GeneID" id="119734206"/>
    <dbReference type="OMA" id="SEYDVMF"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="509"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="73243" checksum="47CC9D07CD00199B" modified="2023-02-22" version="1">MMWRWQEATRPFALCSSPGTGRLNCAPILALYISWLEIQRARKHQEQHLHQLSSIIPSSMGDAEQGEAVRGPRQGEDEKIPFVQGDKQSAAHKKGRLAIIIFFVLFIGAAIVVLPITLHKVPNNNKTIISKTHTEARPAVPGRYQSAAVAADVGLCSEMGRDILKQGGTAVDASITTLLCIGVVNAQSSGLGGGMFMLVYHKNTSKTEALVAKERAPAAANANTFPEKSGIKSVAVPSELSGMWEAHQRYGHLPWTALFEPVIRLAEDGFPVTVHLANARRQVVRGLNLSQPQFAGFRTRYANADGSWKEVGDTVYAPKMARTLRAIARNGISEFSNGTTAQQLVQEIQEYGGLITAADLAGYTAEWREAQAVPIGRGMTVLTTPSPSGGPVVQFIINILRNYNMSSADFKTTGNKIKTYHHFVEASKFAFALRSHLGDVETPEVQEILNKMQSEAFAKSISSQIREDAVTFTNASGYNALLNTAVRSGGTSHISVVDQFGNAVSATSSINNYFGSHIFSNTTGLILNNEMADFDSPASQPASDANYIAPGKMPVSAMSPVIVLNENGGAELVAGSAGSRAIITTNAWVTLRSVFTDASLKEIIDDKRIHNQLQPENIAVYEKGFQKDVINGLHSMGHKTEQKKTPLSVSQAIRRLDNWWMAYSDPRKQGYAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIK6</accession>
    <name>A0A914AIK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063381.1">
        <property type="nucleotide sequence ID" value="XM_038207453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207453.1">
        <property type="protein sequence ID" value="XP_038063381.1"/>
        <property type="gene ID" value="LOC119734088"/>
    </dbReference>
    <dbReference type="GeneID" id="119734088"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="52"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="467" mass="50007" checksum="F910FF20C82F4B38" modified="2023-02-22" version="1">MYISCPCPPGTPSKTFEQESQPPRTLFLHQNSPWTMSGVVSNSLEGPDGGRPGWVAVLALWTRNLMVTGITKGLGIMLPILQIQLTSQMWIIGWIASLTTATSGLVAPFGGLVSRRFGAGYVMMTCGVMMSAAAIAGSFVENSLQLALLYTLLAGTAKGISNVVAKEAVGRCFTKNYATASGIARTGYSVGLIVFAPLVQLFLDTYGWRGTMLLVGAITMHSVASGAVMVATMQPELDQSNAYQTLPQTEHTNSSSAHESTLRSHCGSLWKFVSKNFEVGLLLNSRYWLVAVISCCTTYAYLMWIVYFVSQAQSNGFTLEEAGSFVTIAGIANLFGTISQGLITDRGVMSSWTLVAVCLVMSSVSYLASSLLTSYWPMMTSAVLILFSDGVLSCQTDVLIKQVLGVELLAGAFGWIALKVTLLLVALGFLPGLVYDLTGSYTAAFLLIGSVQAVPLVPLLMLRYSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIR0</accession>
    <name>A0A914AIR0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063441.1">
        <property type="nucleotide sequence ID" value="XM_038207513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207513.1">
        <property type="protein sequence ID" value="XP_038063441.1"/>
        <property type="gene ID" value="LOC119734166"/>
    </dbReference>
    <dbReference type="GeneID" id="119734166"/>
    <dbReference type="CTD" id="64786"/>
    <dbReference type="OMA" id="LPIHVCK"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF645">
        <property type="entry name" value="LD27216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="299"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="617" mass="70857" checksum="DA90A15BFD998767" modified="2023-02-22" version="1">MALASESSETQVLFEQGGVFIHTTQDEAGDVLLGGKIQVTRKSDGAYVEWNPIRDMENSQMVKPDTDWTVVNTVSYQRENSQTTESVTVAQPSRRSRYAMSFPLVDTKKIRRSKPGLGWSYLMFILKDSVSLPPLHFHEGGSPALIRELNKHVTISTCLTDSCLLIVLPHNTDALSQSFTELKIMGETSANKFFKDPYTITLGGFSKVTNFLRDAVMTPAANRPIDEYAELMSDLPSIFSVNSQAEQSYEMVVTESPLGPRPDVERRSPLTEAEWASHLDKEGRVTDVAELQRKIFRGGLVPSLRREVWKFLLKYYPWNSTSKERTALRKLKEDEYFCMKAQWKTVTPQQEKRFSKHRDNKCIIGMSITEKDVIRTDRTHPFYMGEHNPHIEVLHDILMTYCQYNMDLGYVQGMSDLLAPILVVMEREVDAFWCLVGFLDDHGLVMNFDMEQEGMRNQLMQLNNMMQIVDPKLYGYLQSKECSNLYFCFRWLLIWFKREFTMDNISRIWEIMWTGLPCKNFHFLMCLAILDGERDLLEKENFDFSDILKHVNELSCSIDADKILQTAEAIYLQLVDYPELPDTIREVIGLSSEENGLTENGSHASESSIEVLADPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ85</accession>
    <name>A0A914AJ85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064050.1">
        <property type="nucleotide sequence ID" value="XM_038208122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208122.1">
        <property type="protein sequence ID" value="XP_038064050.1"/>
        <property type="gene ID" value="LOC119734586"/>
    </dbReference>
    <dbReference type="GeneID" id="119734586"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815718" description="LRRNT domain-containing protein" evidence="4">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="5">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="132" mass="14136" checksum="402C40F466E0034B" modified="2023-02-22" version="1">MSPGKRRTSPTIAAMGLVVMLQLLAMLTTAVAVNPTGQACDVCECKGPVVICTGRNLTELPRGIPNGTKALELGDNFLREIPYDGLLEFRSLVKINIANNLIKTPFKLPGSVRVIFLDVNRISEIQPGGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJD7</accession>
    <name>A0A914AJD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063524.1">
        <property type="nucleotide sequence ID" value="XM_038207596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207596.1">
        <property type="protein sequence ID" value="XP_038063524.1"/>
        <property type="gene ID" value="LOC119734226"/>
    </dbReference>
    <dbReference type="GeneID" id="119734226"/>
    <dbReference type="OMA" id="MVSATHQ"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051145">
        <property type="term" value="P:smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116318" checksum="005BA7D6339F6D76" modified="2023-02-22" version="1">MSLLARAFAVVFSPGMVTGPAAYMTKKQKQKRSKKSRKSAVAKELEKQDKKLLALRLKLRRPREELVSQGIMPPLKSSPGFHEQRQRLERAKVGDSLQRKIRLRPEKSHLVNQHILADTHVDPLVNATQQRLKRSRLEQDLDSKIKNRPGPLELIEGNILKTENMLVEQAVKDGKVKFLKTNSLDIGPYEFDEDSQEGFSDEALSPSQSDVSQAESQLSRGSLPSAQSSSAFADHSKTLQQQQQQLQQQQKQQQQRSSVSSPSQLLSPKAGQTFVTIKQEPGLISPPPITSNSFTPISAVSNITLSSGKVTPSPRQPRKKQTKRPKPKEIKFHEYKPPNEQSSKPQQASTVSNPYNLLLMQQQLYLQLQLLQQQQLILPNTANQKQNTASASSSNTSVTSTHTTSNPTATTTAAAGAAVPTAPVTPPVPVAVKQQPDVKPNIAALQGKPRGLSNLEDMKVSELKLELKNRGLHVSGTKPQLVERLRPHVEQQVTTSATSPNEVSTTTVTSSTRVSSSTDLDVPFSETASTVQGSLSTPPVSPEYRSSFSVTSEPMSPGSAFDPMSPPTFQNVLTTPVCSPDTVSTTNQQTMSGSGREGSPFDQTMPTLESPQPLPPASSILPVDILNSDNTTQDMMDVSSLDTNTAGSQISNDLLLQQQLKIQELERMLQLSQMQLQMQQLQQPNLSPLSLSQSSTQQHQQQQQSPAGKTTTLSPQQLQPEGKPSAFMFHSKDFAHTLNQQPKVFSFATPPPNGQPFLFSKQQSPDTQSIALPNGMVASKAASLPSSPTERNVLGIGSGMTRSVTQPTFANPPPNYEEAVRQVKERKSQGNTPVNGSPVGSPPKGNIANSDPRSTKCQDLDDLLEVLVDHGYQIPITPKFRDMQRTLHNSTGGLTTITHSVVRGRGGSIDLKLPVPGPSPPPPMTHSYPSTDLPMEVDPTDLNISSLDLGDTSGGGGMARGERTGRTLSAPFDIPMTTIDACETSMDTGKDVGASGSTNPDNDLNWLDLVIPSSASGLTPVSATPPTFNMDGAFGATLGKDPFPLNLLDLNDISTPTDLHHLEDDVWDNIPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJI6</accession>
    <name>A0A914AJI6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063578.1">
        <property type="nucleotide sequence ID" value="XM_038207650.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063579.1">
        <property type="nucleotide sequence ID" value="XM_038207651.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063580.1">
        <property type="nucleotide sequence ID" value="XM_038207652.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063581.1">
        <property type="nucleotide sequence ID" value="XM_038207653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063582.1">
        <property type="nucleotide sequence ID" value="XM_038207654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207650.1">
        <property type="protein sequence ID" value="XP_038063578.1"/>
        <property type="gene ID" value="LOC119734263"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207651.1">
        <property type="protein sequence ID" value="XP_038063579.1"/>
        <property type="gene ID" value="LOC119734263"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207652.1">
        <property type="protein sequence ID" value="XP_038063580.1"/>
        <property type="gene ID" value="LOC119734263"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207653.1">
        <property type="protein sequence ID" value="XP_038063581.1"/>
        <property type="gene ID" value="LOC119734263"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207654.1">
        <property type="protein sequence ID" value="XP_038063582.1"/>
        <property type="gene ID" value="LOC119734263"/>
    </dbReference>
    <dbReference type="GeneID" id="119734263"/>
    <dbReference type="OMA" id="CENHLNT"/>
    <dbReference type="OrthoDB" id="10051587at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000179">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF152">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="11">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="11">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="466" mass="52685" checksum="D61DF19BAE77135B" modified="2023-02-22" version="1">MAHNSRSSNDRAGKSTKDTPTTGGYDAEFHPPLDTKYICPVCLAALRGPLQTKCGHRFCKMCMQRIIGNRPHAKCPVDKSWLDVKKDIFEDVAVEREILSMTVVCSNAGSGCEWRGDLRHLQTHCNTCPCTKLVCPNGCEEQYLRGKSEEHLRDCPLQVLDCSHCGETIIRKDASRHQLLACPKYPIQCEECGQEGIVREEMSKHTDVNDGDCPSTLVQCDYRELGCQCQVKRSELSSHYQEATNDHMQILLTNVITQKALLQTQSASLEERNQNCSQLISAMEEMKKCLKEKDELVNQQVERISHLENTNYNGCLHWKIDLNSYARSNNTSTRILSPAFYTSRPGYKLSACLELDGHVTGNTSYTSLFIVLQQGDFDDRLPFPFSTKCNVTLFDQSERNGRRNSSDFATTITCGNMSRARSGEVRDQFRGRLKLMQTDALSQGRFCKDGVLFMRIDVDLSPTLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK34</accession>
    <name>A0A914AK34_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063925.1">
        <property type="nucleotide sequence ID" value="XM_038207997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063926.1">
        <property type="nucleotide sequence ID" value="XM_038207998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207997.1">
        <property type="protein sequence ID" value="XP_038063925.1"/>
        <property type="gene ID" value="LOC119734471"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207998.1">
        <property type="protein sequence ID" value="XP_038063926.1"/>
        <property type="gene ID" value="LOC119734471"/>
    </dbReference>
    <dbReference type="GeneID" id="119734471"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275694" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="11685" checksum="D53D6B65D26C41F6" modified="2023-02-22" version="1">MKCFILLLLIGACAAAAIEDDTKALEALMQAIDSNELDGVLENMRKNGVSTRFWGGHSCVCHHHVERDEDNSDDAEPMPASMKIKKSRVSRGWWGNDHNCHCGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN93</accession>
    <name>A0A914AN93_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065221.1">
        <property type="nucleotide sequence ID" value="XM_038209293.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065222.1">
        <property type="nucleotide sequence ID" value="XM_038209294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209293.1">
        <property type="protein sequence ID" value="XP_038065221.1"/>
        <property type="gene ID" value="LOC119735556"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209294.1">
        <property type="protein sequence ID" value="XP_038065222.1"/>
        <property type="gene ID" value="LOC119735556"/>
    </dbReference>
    <dbReference type="GeneID" id="119735556"/>
    <dbReference type="OMA" id="DKYWRDK"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="541" mass="61765" checksum="60DECB7DBFD755B9" modified="2023-02-22" version="1">MAEASADPHSHFSEDLASELEALRSIFGGDGEFEVQELPPGSEYCCVVQVKPEGLAVGLKFSLPDTYPDKSPKVEILPTEKNVMLLNDDPILTELLQLLYQSAQEADGEPMMYRLIDIAREWLEGRSLEGEGADEDDDEQEESANKEETAQSLTHKRNKKPTKLDADEEEDYKKKGKKKKKKKPAEDNQGPVKKSRMKTASEVISRIQWDKQVRKEDFIVGYLDRFRGVIEKPFTTFSWVDIATVDDYDSLAIPRHRIQYFKYKDRVVWDKNERLDDVFGSTGSKKTILDTVEVFSKENQSVEEKEASDAVGDDSVVQEATEESDLVQEAKSEEKRRRPSRRPNYFLAIRVTDPVIRRCVRRIQDALCDDDPRLDSSRTDLDSLHITLCTMRLDSQDDMSKAIDVLKSLQRDISELLSPVTMLRFQGLDQFHGRVLFSPPEECPALIKLSQMLQAALGEAGINLVGNRPQFNPHMTIFKMRREEADDFDGTPLRSYLYERFSQAFLGVQPIEAVHLCSMDDPHRADGFYYCLASMDIQSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANR4</accession>
    <name>A0A914ANR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Telomerase protein component 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065670.1">
        <property type="nucleotide sequence ID" value="XM_038209742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209742.1">
        <property type="protein sequence ID" value="XP_038065670.1"/>
        <property type="gene ID" value="LOC119735802"/>
    </dbReference>
    <dbReference type="GeneID" id="119735802"/>
    <dbReference type="OMA" id="LEAWMET"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF4062" evidence="4">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="318"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="121174" checksum="1EA9C4C9E1496590" modified="2023-02-22" version="1">MGCGSSQSIGAVPSGSSEYKYAVLQTWDKVDRTVKKGSKGNQRLVVQRSGWKTVRVFVSSTFKDFHAEREILVKEVFPDLRAWCESRRLHLVECDLRWGIPKDTDSGETLRLCLGEIDRCYQDNIMPFFLNLTSERCGWIPSFDDVPDSIVEEYRWVHGLSVTEMEILHGAYRVDNPNSIFMIRKSEFLQSLPSEYRDDFIDPNPIAVHKLTVLKKMLKARLGNRVRWYDCEYDGIDDHGKIQLKGLNKTFCKAIFEFFKKRIEEQYPKQDTEMDPYQLAREAHESFMKNRGALVLGRNSALEKIHDHITDVGVDYPFVLLGGPGSGKSAVMARVADIAYKMASLNEIPGGGEHGWHVFFHFVGAIPGSTDLEKCLKRLLKEIGAIDESTMPKNEEATCQAAYSTLANPKTKPLIIVIDALNQFDDDTSANILSWLPRKLAPQVRIVLSMIGDTPPHRALKDRGYHPKQYLLTPLDIEARKEIVAEILGRYNKRLDEEQMGSLIAKESSQNPLWLSIACEELRVFGVFNKINDKINSLSDGLLELLEQVFDRFEEENGGSLLVATLCLLETSSTGLLETELLQILGDQDSLMPTEEKTEGEKDGGAREKGLKQIAPLPAARWAVVYRALKPFLRPFGDSGEGRLDFYHRALSKAVRRKYFPKSNEAGNSPRQLWWHRKLADYFFESDNMERKVEELPVHLIKIRDTGRLKELLCNWQAFDLLYEEIFSETLMKYWHEGFGEGWQKLMLQGYEEALLNLENDPTVSRDVLSRRHEEITRVMVHAGAHQDSFKFLNACLTMETELGSRPERMVELYDLAADIYDDKLKLYQWIERWQITELRHLIDFARKSIAIRETMPGNVNKFKLGRTLTQLAFNLEAWMETGADNNLSGEEALEEGKVHIEHAIQIFKDLGNDGYLADAIMTKGILLPRGGDEQLDVCMEALDMCLQAYGENSVLSSRLFLNIGIFHEDNRQYRTACEWFIRWHKCTEEVFGYHHPKTERARKTLERPVYRRIKQQIEEEQQLAEAENNEAENNEAEDNEVDDVLNRMRNAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANR6</accession>
    <name>A0A914ANR6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065074.1">
        <property type="nucleotide sequence ID" value="XM_038209146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209146.1">
        <property type="protein sequence ID" value="XP_038065074.1"/>
        <property type="gene ID" value="LOC119735448"/>
    </dbReference>
    <dbReference type="GeneID" id="119735448"/>
    <dbReference type="OMA" id="RVANNEC"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="568" mass="65476" checksum="FCEBFA60F0CD7A3F" modified="2023-02-22" version="1">MFQPTCNTKLFHDKPVVSSLHQRASCSPIKMNPANQQQPPLNQPAMIRVMRRLRRRMVQGNGDEVADHSDDDEPLEEEQLRELMQRGATSNRTQNKTRFAELLAVKKRVADGKKMTELRKRKMQQKMTPLFLNDCVSALFNNTRLSDVTLKVGPYLFHAHKLILCAWSEVFRAQMNDRWSSSSPNDEPQVHTLNEHEACEEYFEDFLRFFYTEEVNLDEDSVFCILILADKYMVRDLKDVCEKYLLALLETSTAPFVDAMKSLKLAEDLSRVEQKSFSLLENHFHMWTTDDDAVPTLYWFDAELLEKVLQSSNLVVPNELFVFGAIRRWLRTESCKVEREEYTDQLLSLVRFEHIPASVLAHLLDGCSATLEPKVKEYVIQALKTRALAGEEAYEDMCKEFSNPRMYLEPAFCVRITNTEWRIDDGSTFRQLELCVEDSKAEFDRCKLSCPVARQSENKNIYLVSKETWEIGGLAVKESSGEEWSVRFMLKPNFEDIGRSYRVAIVSSKSDPKVQSFNAPFTCVDTGDIGKQIAIYVPATTLRCNSNPNRLWVRVGIQVSGRDKSCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP58</accession>
    <name>A0A914AP58_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065224.1">
        <property type="nucleotide sequence ID" value="XM_038209296.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209296.1">
        <property type="protein sequence ID" value="XP_038065224.1"/>
        <property type="gene ID" value="LOC119735558"/>
    </dbReference>
    <dbReference type="GeneID" id="119735558"/>
    <dbReference type="OMA" id="GNISICA"/>
    <dbReference type="OrthoDB" id="10062605at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008677">
        <property type="entry name" value="MRVI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15352:SF1">
        <property type="entry name" value="KASH5-LIKE COILED-COIL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15352">
        <property type="entry name" value="LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05781">
        <property type="entry name" value="MRVI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="915"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1238"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1288"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1542" mass="170661" checksum="CEF459F91BB483BF" modified="2023-02-22" version="1">MESGLGRSLHSELRSVVSADGDLPSPICGNEDFDFENHIGGNSGVAPDTPLSRQLSSSSSTCSSSSKATQLLRHFRQRKEDVMSQLQAFLDENDDQSGGEDTGLAPKVAFTQLLDSELDSMIERMTSLAKTKKQSEQRANKLSFMLQSLQDDYVRITKKYEEAIKHCKELTATKSQLETVRMENQTLQFDIQRGKQKTEELEKDLSSLQRDLETAHTAQQNYRQMAETQLGELRRLFKEMEKKYKIAQDNTRKQEASYKAKVAQQASTHRAQLKSLLDLVSRDSCVDPPLLQQVVQSSHESNQGSRSNKQVLETVSAYLTGLKTQLAKVRGQLISLKREKFSLEYRQLRLKRGRNREGCSKQTLPRGSREGCVCSIDTDCSVLLDALTLEVIDKASQGHSNSLLLHHQSAKLPWQQTDHLSQDDSLVDCLRDAPGSVIDKLHFNLLREFKTKKRRKSQTVATQTEIQRTPDRQVRPYSRSSHSQTSLADSRNRDTDAQTETDSADEFRLSSLQVTNGADVKQAYLVNKPPTLSSAILLPVDEASSPGDSASDLSDSFVTAFSSPVSCSPLRGSFRSSLERDDFSDILASPFSRNGSPESPSGTPDKEPSDSQEVPPKIPVVKPDIKIQSLQRKSAQDRQEAAQRMADMLANSYARPNIVVEGCQADSEDNDVNANYDRSGKYSPSTPRKLSPARLKRRSYLDKEKDKRTSALGSEGKSLELLLSGNLSDVDMTEEEKEITQRLLEASKKASERHKNRRGRRWSPSTSPEQRSLSPNSADRSRSPSPSTRTPEDQSPPSAPGETPPGTLGGVTDPTADKVTEGTAEGTAELQEERTGAEGESDKEDNKQTPKNERKDSEVEVFDIKADILKATGSLQAEMPPVKPILPLAKLREEHKQHRKTNFQFTMPELTEATEVDHGRENPSLSATPVPPTVTTLLSSHPTPVPGSPGPEIQYNSVQDSTTVVEEEGEKEPEKSKSSEEEKSLLPDSILYKLGLKVGNSKDTIAMTENEIEEKFNSLQLAFKANQYTLDQRQKLQHRQRDLAEKNIEGEIEGLQQTLQLLEPLAGADTVSRDCINRIKQHVEVLQSSSLRLSSKAEGFGAVQQEGRLSKATDVMITHVENLKRLFEREHAELEDARKLLQENRKWFRGNSITNNLSIDGETDSKLLSRRALSVSGGSSKSEIRKRSVSCVSPPRLGVPHSFFPDPNQTGRRRASVATVVGSGLLSSSYASQPLSFGGQHFRSQTEPSGISLGQGSHLTGGVRRTSMQLSASLNAADFKEAKARLAGSLSPGRHTPLSRTDSSIIINRRASDEGQATEHASLEGTISAPALSASSPSGSSPLPSPSRRHAVSLPATPNATTMASPVATAMTTPNTFPKIVDPEAVKKGLAEVDSNEAKNVKKEEVFQKGYEEGVRTQVTHELADLREQQKAFCDNLEDLIDQAEEEEEREEAEKEIQADKSSNKLFQRLQEVSQRWPRAVRVARLVLTLSVFLIALAYVFVTVVPLESCLSGSPVSYSPWRTLKEFLWPYTELRHHNHPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914API0</accession>
    <name>A0A914API0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038065657.1">
        <property type="nucleotide sequence ID" value="XM_038209729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914API0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209729.1">
        <property type="protein sequence ID" value="XP_038065657.1"/>
        <property type="gene ID" value="LOC119735794"/>
    </dbReference>
    <dbReference type="GeneID" id="119735794"/>
    <dbReference type="OMA" id="KEVEPQH"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915908" description="small monomeric GTPase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="22807" checksum="1C12AEB33559EAEE" modified="2023-02-22" version="1">MFVFFCFVAALVVRYLTHRFIGDYDANLESIYTQSAKIDDQHININLVDTAGEFDFESPARQEQIRTSDGLVLVYSLVDRDSFDYLSYIQQFISRVPGRDSEKIPAIIIANKSDLCHLRTVSPTEGADFAKELGCPYYELSASESYIDIGDALHDLCREIYRAEKRAKVKKISARLQLRQTIKNFTDRHIYRSRTNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS46</accession>
    <name>A0A914AS46_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066196.1">
        <property type="nucleotide sequence ID" value="XM_038210268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS46"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210268.1">
        <property type="protein sequence ID" value="XP_038066196.1"/>
        <property type="gene ID" value="LOC119736230"/>
    </dbReference>
    <dbReference type="GeneID" id="119736230"/>
    <dbReference type="OMA" id="NDIDHES"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038033588" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="169" mass="19185" checksum="15050BDBB660A796" modified="2023-02-22" version="1">MAMRHALILLVLVSIARADLECGPLWSRFGDHCYRFFGPPKTWQNAEDHCRKFFTRFGQGHLASIHGEAENNVLLELWESSLPSLDGVGSHAWLGANDIDHESRFEWTDGSPFNYGAWRDGEPSNSGNAEHCLNFFNWQGAIGWNDANCSQYEFPYICKVSTAEEKDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AST6</accession>
    <name>A0A914AST6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066723.1">
        <property type="nucleotide sequence ID" value="XM_038210795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AST6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210795.1">
        <property type="protein sequence ID" value="XP_038066723.1"/>
        <property type="gene ID" value="LOC119736785"/>
    </dbReference>
    <dbReference type="GeneID" id="119736785"/>
    <dbReference type="OMA" id="NCGYPET"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19438">
        <property type="entry name" value="lipocalin_Blc-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047202">
        <property type="entry name" value="Lipocalin_Blc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF1">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036919140" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="44477" checksum="E9AB00FC7A636912" modified="2023-02-22" version="1">MYFLSVFLLAVFTVCRGDIPTVSELDLKAYVGRWYQPYQNRWTKITNFDLDSVCTTADYKIINQTFVSVYNAGREGWPEGKRRDIAGFAYIPDPSKPGRLKVVLEGVPAAGDYLIIKIGPIIDGQYQYAVVTSSGDRALYVLARNPISFLDKYAEEVLKFLDENGYQGFLKKPQPLLQATNCGYPETREIMDVLFAAVLALCLAGPSLAAPGYASPPKTVGELDLNSYLGRWYQMFADLVVDSTFERNAYCVTADYALNPNKTISVYNANTVGSPTGARNAIKGYAYVPDPSQPGQLLVKFPVTPVAGSYWVVQLGPKETTWRDSDPQYQYSIVTDSLRATLFVLARDPDDFRSRFQADVLQWLKSNQFDHFYNKPVETVQTDDCKYPPMGGKKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATG8</accession>
    <name>A0A914ATG8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067067.1">
        <property type="nucleotide sequence ID" value="XM_038211139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211139.1">
        <property type="protein sequence ID" value="XP_038067067.1"/>
        <property type="gene ID" value="LOC119737067"/>
    </dbReference>
    <dbReference type="GeneID" id="119737067"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="19250" checksum="DA01F2A4DEA0440E" modified="2023-02-22" version="1">MCPVGYYDVDCLSKCRCPNDTACDKDNGKCVCAPDDVSCLSSPANETQFNIVLLAAIGGGAVAVTVSLCVALVVCWCARTRRPSRRPDQPDDGENYDAPQEHDDVQATGPPGGKYSLAVGGQGWQLPRPTQAHPEPAAQIYENEDGDNHSAEYTNVNPGRGRVSYTNNIEMENYEPVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUA2</accession>
    <name>A0A914AUA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067645.1">
        <property type="nucleotide sequence ID" value="XM_038211717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211717.1">
        <property type="protein sequence ID" value="XP_038067645.1"/>
        <property type="gene ID" value="LOC119737391"/>
    </dbReference>
    <dbReference type="GeneID" id="119737391"/>
    <dbReference type="OMA" id="DARCWYE"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="706" mass="78477" checksum="DEDD85CE45C8047A" modified="2023-02-22" version="1">MGVKGLTSMIEQHPSLFTRHCLHDARLVIDGNALKYFLYQDRPPCDNGHHGGRYQIFSAKCQRFFLNLAECNISPYLVFDGALEMDDKKLAETKSRSQERIRTAVAIPSGSGGIAVSPCSALVFMKVLDDLGIPYVFCDFEADAETAALANALDCAAASGDSDFYIMDLRDGYLPLNHFDWMNPKMIKVSEAAAPSGQLYIECKKYKSSAFCKMFHVKQTLLPILATAVGNDYKDTFGASLDPFQSFVHSKFFSSKTGRRSYDQIVSYLSWLKEKETKEEAIYDMVRHVRGADREKLRRLIDASLEMYHFSDSLTVAHFTGGQLNPKRSKLAACASVPPWFVDLLNRGKVAAMCANVLCNKRVFLKIQVEDSRQVSAGGASLNIRAILYGILLKGQKSASRRPPVVEEYAQSSGSLKHSIVEPAYDIAGCDGRKLALPSLQDIPDMYETDRREILLAAAGIGGSVILSIPALFQLATCVTLNLLSHANPPVYSDQIVALLVSWLHGVAASRQKYINKDQDTPKLLQVDLENSDMHAILTNCKPHENKYEESRQLDVEVIQAMAQWQQCLLDLVHLNKVLLSPFVYPDMAVLYNGPLIHSLCIILKPMSSTEQQLQWVVRELLGDTMPGIHALLDQLLKPLSPFLMPRKRTNKSKKGKKAPSRPGTSRPSMDTPPARGAEGGAERDTEEVFYSVRVSNRFAALGWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWA9</accession>
    <name>A0A914AWA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068390.1">
        <property type="nucleotide sequence ID" value="XM_038212462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212462.1">
        <property type="protein sequence ID" value="XP_038068390.1"/>
        <property type="gene ID" value="LOC119737841"/>
    </dbReference>
    <dbReference type="GeneID" id="119737841"/>
    <dbReference type="OMA" id="VACESPH"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF487">
        <property type="entry name" value="SOLUBLE SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="246"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="363"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="284"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="762" mass="82056" checksum="28980ABACDEC965E" modified="2023-02-22" version="1">MDSTGPSLEVLAVVIILQVFTTVASPGSYLRLVGGSDPSEGRLEIYHNQWGTVCDDSWGYTDALVACRQLGFTAVGTSLYSLPGASVPILLDEVRCVGDEGRLAECPHNGWGVHNCGHYEDVAIRCGYQNTYADPMPIRLSGGSSNSGRLEVYLNNAWGTVCDDNWDLADAQVACRELGYAAVSNYLLPAIEGATGSILYYVGCEGGETRLAQCVHLGGDWGTRYCGHDEDVSLACDQRRTDTIALRLADGINSNEGRLELYHNGQWGSVCDDHWDEADATVACREMGLGSPTHPTAVDSIPAGTGPIHLDDVMCDGWEARLIECGHLQLGSHNCQHYEDVKIACTGDDVYVMAFTVPMGYSFHLVDGLSPYEGRLELDIRGIAVGICDLDWTLQDAAVACRQLGFGTPIREVQDGYFGVNPAGYYWANNVSCSEEEVSLQDCTTGNMEVVSSCGHGGLDVGVACTGPFVGNEHDMRNADVRLAGGLTAADGRLEIFFNGEWSTVCNDEWDDVDADVVCRQLGYRKVLNAHHYIDGLPAGSGSILLDNVRCQGDEITIMGCRHNGLHTHNCGHWQDVVIECYHGNEYDWTLSGEKIFAIIGVLFVAITLGLFIIKRRMQLEKRRQLVVVPANDQTPSAGVGPPVTPHPYPVQPLAGVGRPVSPHPYPVQPTGPLPQLPPGQPPYAAAVIPALPPVGFPDPNPLPPSYLTATAGADGMNQLPIYLPSPVAATTGLPPVQGMLPQQLQPLNNLTLRTSPSYPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY51</accession>
    <name>A0A914AY51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069075.1">
        <property type="nucleotide sequence ID" value="XM_038213147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213147.1">
        <property type="protein sequence ID" value="XP_038069075.1"/>
        <property type="gene ID" value="LOC119738302"/>
    </dbReference>
    <dbReference type="GeneID" id="119738302"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="63"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="172" mass="19555" checksum="F9D4376245C196F1" modified="2023-02-22" version="1">MRRLVKELNTRLLSSITVMTMPLPRTARQVIVVPIAFIRRFTSGNERCVASIRGACPPAWIQWGDKCYKAIIKPLTWDEAKHECIEMGSVLVMPQSQAETAFLLENLLSFYWIDCNDQQVEGEWVCQDGTTDVEYREWRVETGEPNNSKGREDCAAADKSGWIDISSILVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1C9</accession>
    <name>A0A914B1C9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069797.1">
        <property type="nucleotide sequence ID" value="XM_038213869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1C9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213869.1">
        <property type="protein sequence ID" value="XP_038069797.1"/>
        <property type="gene ID" value="LOC119738979"/>
    </dbReference>
    <dbReference type="GeneID" id="119738979"/>
    <dbReference type="OMA" id="EIMTRTT"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195018" evidence="9">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="332" mass="37625" checksum="CDFB0913EDFE34C5" modified="2023-02-22" version="1">MKRFRQKESLGWTGVIVMMLFLDGVFEIGHTVDDLVNKTIEYLQPNPVSRAMSKVRGQNKGGTKPQQPVGFLGEVMLKNGRELGEDSTFGTAMVEMGESLRQLSEVKGAFDLNVRQNFLDPLDHLKNKDLKEINHHRKKLQGRRLDFDYKKKKQAKGSTIPEEEIQFAEEKFHESQELAENGMRNLLESDVEQVLQLQALAEAQLEYHKQSAEVLESLLSTLNERVEEAGSRPKSERKPRSTFNSYSTKRDSSDGDDTDAYPSTVDYNAPVPVTATKERCKALYDFEAENEGELGFQEGDIISIVSKIDENWIDGELNGHTGYFPANYVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3C6</accession>
    <name>A0A914B3C6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Membrane-bound transcription factor site-1 protease</fullName>
            <ecNumber evidence="24">3.4.21.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Endopeptidase S1P</fullName>
        </alternativeName>
    </protein>
    <organism evidence="34 35">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.</text>
            <dbReference type="EC" id="3.4.21.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.112" evidence="24"/>
    <dbReference type="RefSeq" id="XP_038070006.1">
        <property type="nucleotide sequence ID" value="XM_038214078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3C6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214078.1">
        <property type="protein sequence ID" value="XP_038070006.1"/>
        <property type="gene ID" value="LOC119739226"/>
    </dbReference>
    <dbReference type="GeneID" id="119739226"/>
    <dbReference type="CTD" id="8720"/>
    <dbReference type="OMA" id="LEYTTTG"/>
    <dbReference type="OrthoDB" id="1740355at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07479">
        <property type="entry name" value="Peptidases_S8_SKI-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000008">
        <property type="entry name" value="Membrane-bound transcription factor site-1 protease preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055143">
        <property type="entry name" value="MBTP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057060">
        <property type="entry name" value="MBTPS1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057032">
        <property type="entry name" value="MBTPS1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034185">
        <property type="entry name" value="Site-1_peptidase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF7">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23001">
        <property type="entry name" value="MBTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23094">
        <property type="entry name" value="MBTPS1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23090">
        <property type="entry name" value="MBTPS1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 27" id="KW-0645">Protease</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 27" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 29" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732347" description="Membrane-bound transcription factor site-1 protease" evidence="29">
        <location>
            <begin position="27"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1022"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane-bound transcription factor site-1 protease-like N-terminal" evidence="31">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="30">
        <location>
            <begin position="235"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 third" evidence="33">
        <location>
            <begin position="512"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="32">
        <location>
            <begin position="642"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF23001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF23090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF23094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120447" checksum="CCBAE3ACC100377A" modified="2023-02-22" version="1">MKGWLCIVPVCHLWLVLILCPQGTLTKQTLTSHEYSAEEQLPSPCDIFNETDVAPDVQIDFTTQSVSNEYIVVFKRYYFEQTRLNYISAALRNSPPFSWNVVSRSNPAAKYPSDFEVVRITAGEEDSVASLEHHPSIKQVTHQRQITRSIKSMPEDEQLQDEDEDEGDMCNSAVDPLCWAPKWKSSRSMRRASLGLGSSFWETGRHAGRKLLRALPREITDILQANVLWDLGFTGAGVNIAVFDTGLKEKHPHFRNVKERTDWTNEKKLHDGLGHGTFVAGVISSTSECKGFAPDANLFIFRVFTNNQVSYTSWFLDAFNYAILKKINVLNLSIGGPDFMDHPFVDKVWELTANKVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGINFEDNIAKFSSRGMTTWELPMGYGRLKPDIVTYGSTVRGSSLSGGCRTLSGTSVASPVVAGAVALLASSVWDRQEMLNPASMKQALMASARRLPDVNMFEQGHGKLDLVRAYQVLSTYNPQASLSPNYIDLTECPYFWPYCTQPIYHGAMPTIVNITILNGMGVTGRVIEKPVWQPFTPQNGDKIEVAMSYSSILWPWSGFLAVSLTVSSSAASWEGIAQGQITLTVESPPESGEDQPRQSVLKLPVKVHIVPTPQRNKRVLWDQYHNLRYPPGYFPRDNLRMKTDPLDWNGDHIHTNFKAMYQHLREAGFFVEVLGAPFTCFDAKQYGTLLIVDPEEEFYPEEVSKLKRDVDQGLSVIVFADWYNVTVMKKVKFYDENTRQWWMPDTGGSNIPALNDLLAPFGMAYGDGVYEGDFHLNDHKASFLSGSSIVKFPSGGLLIHQTLKDQGQDVIHGKGDLVNGVPILGMYQHSLESGRIVLYGDSNCLDSSHMKTDCFWLLEALMQYTAYDNLAPMFGQTKHISLPPAVALPTRMEGNHLYRYSKVLDPHQLGDPKPRPLPACPHLAWAKGEPLNISAPSNLFKHQKLLSILEGVPPPAVVAGANMRRDEPNVPGLQEDVHWDPRNSGNMVVSDNWSTVTLLAFVSGFLVLGFFVNLLYRSRRKRKQAVTWRKKPTRLIRRTKYTRVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4H8</accession>
    <name>A0A914B4H8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071186.1">
        <property type="nucleotide sequence ID" value="XM_038215258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4H8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215258.1">
        <property type="protein sequence ID" value="XP_038071186.1"/>
        <property type="gene ID" value="LOC119740057"/>
    </dbReference>
    <dbReference type="GeneID" id="119740057"/>
    <dbReference type="OMA" id="CHDICRE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="40424" checksum="5C81EACE4C046AC9" modified="2023-02-22" version="1">MAKKGVHGSSLWNFAEEHLTCSICYNLFDTPKTLACLHSFCENCLLQYHDGYSEELLCPVCRQADSTALGGVESLTTDFKLVNMVEAVRQEDKQTAPFCSEHAGKPCRAYCQTCEELLCLNCLAESDDHSEHVLEEVREVVDGKRQAVKDHMPQYQTFMKDIAVALNQTDTLEQDFDLALDKTRKEVQHKAEMEIAKVNAAKNILLDELQQIQSKRKERFAENKLELTGMRNTFQQIIDHSTDAMQEINDYDFMKRYQRLSNDFQYLSNSSLPSIDANASFLKFDPSTRSLDSLLFSSRCYRQRRAGCRTYRLFSRKEQVNVCPHAQFLVNNRVLNKYVPWASWGLLNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B648</accession>
    <name>A0A914B648_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038071285.1">
        <property type="nucleotide sequence ID" value="XM_038215357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B648"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215357.1">
        <property type="protein sequence ID" value="XP_038071285.1"/>
        <property type="gene ID" value="LOC119740149"/>
    </dbReference>
    <dbReference type="GeneID" id="119740149"/>
    <dbReference type="OMA" id="AANTHCQ"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="386"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="704" mass="79959" checksum="08C4B371C99C4DB1" modified="2023-02-22" version="1">MAEQRKDVYWFMHEERGIPEAQIDRMKQEKIDETVIPFMTDQNLQGYLPLFGDRLAVINYCKSEQKHGRGPEENKLIQKLRLKMMNRRGQTEARDTSQHVPKLGNKNARKDTRRVDFGWLNYNSKEKSYKQVRKQHGGGTRQMTVKKDCIAHQLKTVAEGLYFKEGQSSKGPLHKFETALADFTQHEISDNETVEEKYNAAHMPVLRFYLLTKEKDTKAAKQETDEEDSADFSVSDDEQYLDVGQEVQVETSDEASNHQAEDADARGMFEQTDTPTIQFRKQKQDVHLEGGCSSGTSCYKSYIELLSDSESDVEDIELAAAIEASLQDTQPLNDDRNNEDVVRNIITKLAGRRSDGEPTTIVVHRKRLLASTMRAVSRPGFSFWTQVRIVFSGEDAEDGGGPRREFFNLLVKELQSSGIFENCEGRLSFKYDLQKISQRAYDMAGKLITWSLANGGPGLCSLSPSVFAAMVGQPVDTEDIRYLPDQMFQCNVEKLLGSKQEDFPAVIVELTDWLIDQGLTSIHKIDFADRDNLVKELVTHQIYHRVQSCIGQFTDGLGPLWEDVKGSPKASASLFIYDDHPLSVDVMRKLYKIEYSPPGSNNRNQEEDTIYCFEVFLQNCEDEITEVSLEDILEFWTGAPKPPPCGFSEDPKVSFFTAVSGIKRLPSSHTCGPILWLPRGKEDPDEFQAMMRFAIKETQGFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7Z0</accession>
    <name>A0A914B7Z0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071547.1">
        <property type="nucleotide sequence ID" value="XM_038215619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215619.1">
        <property type="protein sequence ID" value="XP_038071547.1"/>
        <property type="gene ID" value="LOC119740352"/>
    </dbReference>
    <dbReference type="GeneID" id="119740352"/>
    <dbReference type="OMA" id="CISYLAD"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="472" mass="51917" checksum="48B955340FC7A4E8" modified="2023-02-22" version="1">MAHPSENMKSPASSVKLTGRERAQTRWITVEPMIILGMMGYTCLALVRPLFVKDRIRELHNFTENDTDKCSDAHSDNDTLGDKIQAESSVWLLYLTAASGIPAMLSTIVFCTMSDRLGRKIAMALPALGFAIQAAVYGFTVHFKLPLAVLFVGDATQGLTGGFGLLFAGCISYLADATSEKQRTIRIVIAEMLTFLVGGMNQLGQGYLITFGYLPSLAIAFGCNAAAFLYIVVPWFVIETIESSRSDRKEFIDVWRRMKRLLEFNENGRRWQMLLLDFFIFFCVGQFQGISAIYVLYGSAQPFCWLSSTAGIGLAVGWVASSVGMLVGTKLFSYCLGDYWLMQISCFSIMLSYLIIGFAKSTLVIFLGTAVGCLRGMSIPVARSVLSKITHPDEIGAMFSIVGCLESLTFASGLIATSIYAASVSFLPPLTFYVYSAATIIPAGIILLLQIRWPRRKEYVPLKTVVNAEYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAZ8</accession>
    <name>A0A914BAZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073015.1">
        <property type="nucleotide sequence ID" value="XM_038217087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217087.1">
        <property type="protein sequence ID" value="XP_038073015.1"/>
        <property type="gene ID" value="LOC119741336"/>
    </dbReference>
    <dbReference type="GeneID" id="119741336"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="18">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="660"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="103122" checksum="F87DC02B4F75B1AC" modified="2023-02-22" version="1">MGGTVLGLCATNLSIFPHKETGCLGLRLKLHALLMVDILPAFTHTNNNSTSMEVFFWNTNKSPAEPDGGQGQDCVFIYTDELSGERTDINNAWGDDGCNTKNNFICSQPSFILVPTISTQCITAGQVPVSVTWNEVTGIDKETATVISVTCQDSEDGMDVNVTGGIFGVGSHSVICIARFSDGRMETAILTFNVTISPSLTLSTVGEQFTDEVQSNASVTWPAVTATTSDDQPITCTDSSEDEVSLTGGVFGVGSHTINCTVINDGGCITSENFTFNVTVCSLGCLNGGTLNLQTCRCGCALSWVGPSCTECSLSENSCLNGGSLSTEYCQCICPAESSGVTCEVKDPCIATPDPCSEMTGQYCVPDPYESPDGYQCECLELDGYFLNSDTNTCTRDGFKSVVVILTVRGINGTAIKIQIDFSDSNSEGSQEFLATIARVIQFELLNNTATRDIESVRGVLLHVESDSVVFTGVVRAAAISTVTVSIILDVLTTKAAEGILTDGVTTLHIDPAITVKDTNDCNPNPCVNGVCEDGINAYTCICAAGYAGKDCEIKIGHEDITVILVAAVSVLATLLVVIVVIVIWRKMKQRTPHRSSLAMEMVPEHASRKPQNNMPAIGLDLVDYDDTAEAEGIVPSIDYEDIGLPTWAARWEILWRNLVVDEQVLGKGNFGEVRLGTVNIAGEKTKTAIKILRGSASTGEQEDFMKELRTMTDIGYHPNVVSLLRACYHKDVLYVAMEYLPHGDLRTFLRSTLSESDSNLTSDHLLKFALDISMGMQHLSRSGVIHRDLAARNILLGEGLVAKVSDFGLSRVEDIYVQMSMRRVPTRWLAIESLMNQTYTTQSDVWSFGIVLWEIATLGGTPYPAINDTASLAGRLKGGYRMPQPSNCRQEIYSVMLQCWDDNPNNRPSFTDLVSILGQMDDNKIQHTYMTVDLSHYVNSSVIRRGLDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC42</accession>
    <name>A0A914BC42_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073400.1">
        <property type="nucleotide sequence ID" value="XM_038217472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BC42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217472.1">
        <property type="protein sequence ID" value="XP_038073400.1"/>
        <property type="gene ID" value="LOC119741640"/>
    </dbReference>
    <dbReference type="GeneID" id="119741640"/>
    <dbReference type="CTD" id="6139"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="191" mass="22028" checksum="B49EDBAA574E78F4" modified="2023-02-22" version="1">MSKCVDNMTRYSQEPDNATKSCKARGSYLRVHFKNTRETAAVIKHMHLRKAVRFLNDVTKKKQCVPYRRFNGGVGRKAQAKAWNTTQGRWPKKSAEFMLQLLKNAESNAELKGLDADSLVIDHIQVNAAPKMRRRTYRAHGRINPYMSSPCHIEVILSEREQVVPKPDEAEKKTKKVSKKKMARQKMMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC97</accession>
    <name>A0A914BC97_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073057.1">
        <property type="nucleotide sequence ID" value="XM_038217129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BC97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217129.1">
        <property type="protein sequence ID" value="XP_038073057.1"/>
        <property type="gene ID" value="LOC119741379"/>
    </dbReference>
    <dbReference type="GeneID" id="119741379"/>
    <dbReference type="OMA" id="FANYAFI"/>
    <dbReference type="OrthoDB" id="10058156at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="530" mass="57930" checksum="39F872D67A5B1341" modified="2023-02-22" version="1">MESCIFAQSPYHPASNGLAERAVRTFKHAMRRMDTGAVETRVARFLFHYRITPHTSTGLSPAEMLMGRRLRSHLDQLRADVAQRVIKQQEKQKHHHNKHAKTRVFGIGDTRPTTGQNHKHRPNLNRNLFHQLTGNAQIVSGVHLTAMASQTLNLRLFARPLEVMFGTRTVVTVSGFILGVSMIIASFATSIVMLTSILALAAGPALSVVQILTRALVGRCFTTNYGMAVGIGTSGGAVGAITVGPFTQLLLDTYGWREALLILGGLTMHLGVCGALLRSASTDETNDSYQPVSTGANEEPQVGSSSAEKKGKLKQSSRLGAFKDALGAQIKHFGFSVCFKYSFWITAVPFICSRFVGDQWMIYYVSQAEAKGFSPHDAVTFTTAGGVGNVVSKILLGVIVDKGLLKLRPVIALMITLSSSVFLITPWINSYWLMMVTAVIYCSGHGSIASLNDMYTRELIGTDLLACAFAWMELVTAIFSFSLGFFPGWMYDQTGSFDWAFSIMGCISALSLMALLMEWVQARCKSKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCA7</accession>
    <name>A0A914BCA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073067.1">
        <property type="nucleotide sequence ID" value="XM_038217139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217139.1">
        <property type="protein sequence ID" value="XP_038073067.1"/>
        <property type="gene ID" value="LOC119741391"/>
    </dbReference>
    <dbReference type="GeneID" id="119741391"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="232" mass="27301" checksum="3144654D8D978129" modified="2023-02-22" version="1">MDFTVNLLMSIERTGARPDVVVVAEDEQSFKELSLHPHPGLQVVKPHNISGVNIDSKNAHYLKFGTGDYNKFVNRRPKYILEFVQRGYEVFFLDADTFWFRDPFPYLEGNFDIAYYNDRFDMYNMGVAFYRPTNRTLRFLKHFALTLETQKKVIPDQNVMNTIIRSQYIPDLRIKHLNNENFPNGGFFFPFFPNMTKCREDTSTTVVFHAAWISGHKNKKKAFQTCHMWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCM2</accession>
    <name>A0A914BCM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073978.1">
        <property type="nucleotide sequence ID" value="XM_038218050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218050.1">
        <property type="protein sequence ID" value="XP_038073978.1"/>
        <property type="gene ID" value="LOC119742033"/>
    </dbReference>
    <dbReference type="GeneID" id="119742033"/>
    <dbReference type="OMA" id="DNSHENT"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="83"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42520" checksum="DC4D24F0A3720BDD" modified="2023-02-22" version="1">MATTIVPENMTVVSTTSYFLSSDFTTSDALDATRASVNSNMTTTAMMETTTQGDGRNFRLEDPVQRIIIGFVYSLVAVVGFTGNSMVILAVILSRKLQTRTNAFVVNLAVADLVICSTVPFTALALFSMNGWPLPLIVCSVAAGLFYTSLACSIMNLALIAINRFVLITKSSKTYRSVYTPKKIAAMLVFTWGYPALLCCFSLFGIGKFGYSEKYKNCSLDNSHENTGLLSLLGSVLVYPIPLIILFVCYFKIYRHITNHMKKFTSEGVELADASKPSTASTERLARNPPASFSKRQVEITKNLFYVVCAFVACLAPFAIALMILPSDPVIPWTGMIVIFNSAINPIIYGAKHPHFKEVFRHMLRCRYHMISEPSGFLRKIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCS0</accession>
    <name>A0A914BCS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073232.1">
        <property type="nucleotide sequence ID" value="XM_038217304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217304.1">
        <property type="protein sequence ID" value="XP_038073232.1"/>
        <property type="gene ID" value="LOC119741492"/>
    </dbReference>
    <dbReference type="GeneID" id="119741492"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000244">
        <property type="entry name" value="ETS-related transcription factor Elf-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="386"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="55835" checksum="F01EBBE704AEE129" modified="2023-02-22" version="1">MVPSAQCFYQLSREVPHQATMMTHGPVNYPVMQQPAYQNYDVYDEEDWSEIVDSVALPSENQLLDLLNSLDLYQDDSMNPMCNNDMLFPDLSADHTHMTSDLPQAMRVSMSGEEESLRSVLTPPDSPVFAELTTPHNQHTTPNNQGPMFQEGVVPNLKYEPQDTYNIMNTMCSPMYPEQPSFSEGIICDVPFGASNHVLVKQEFIEQEFSDCFSNGQAESAAPQWQHHGYLDYEDYPPAPQHPPTFDANFDTLPNVEHFLKTLMDPQRPTNPSYQYRGSNSAGEETEFESESEASFTLPNSPATSDEGYLSISQHPTAHAHRTHNYQRKTIDKSLSLLRGVTHKDSKRGRGRPRKMHPISSTSSDDSDEEVTTRRGRGRREAMRGNHLWEFIRDLLKDSMCCPKYIRWEDRKDGVFRFVNSEAVATMWGRKKNNPQMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNAAGWREAAGLDSDTESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD52</accession>
    <name>A0A914BD52_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073984.1">
        <property type="nucleotide sequence ID" value="XM_038218056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218056.1">
        <property type="protein sequence ID" value="XP_038073984.1"/>
        <property type="gene ID" value="LOC119742040"/>
    </dbReference>
    <dbReference type="GeneID" id="119742040"/>
    <dbReference type="OMA" id="LDNKCTI"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="353" mass="39106" checksum="57F2EB82A16A6A81" modified="2023-02-22" version="1">MAVTDGPAVKEEEINALTREAESLKIKLEEERRKLNDVDLMVVAEKLDTLPQLNLKPRRILKGHQGKVLCLDWARDHRHMVTSSQDGKIIVWDAFTTNKEHGITMPTTWVMACSYAPSGTIVACGGLDNKCSVYQLSQEEDLSTKKRAVAMHTSYVSCCTFMNSDQQILTGSGDSTCALWDVESGQLLQSFHGHNADVMGLDLSPSEACNTFVSGGCDKQALVWDMRSGQCVQSFDGHESDINAVRFFPSGDAFASASDDAGCRLYDLRADREINCYAKECIIFGATSLDFSLSGRLLFVGYNDYSVNIWDTLKGIRLTMLYGHENRISCLRTSPDGTALCTGSWDYTLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEE5</accession>
    <name>A0A914BEE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C-type lectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074341.1">
        <property type="nucleotide sequence ID" value="XM_038218413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218413.1">
        <property type="protein sequence ID" value="XP_038074341.1"/>
        <property type="gene ID" value="LOC119742478"/>
    </dbReference>
    <dbReference type="GeneID" id="119742478"/>
    <dbReference type="OMA" id="SSAIWHY"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037907805" description="C-type lectin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25283" checksum="027CCF7A3C9510FA" modified="2023-02-22" version="1">MAKMGRALALLLAVATTVSAQTTQPCPSGWRAFNGNCYYFGDMKYWTEARDDCLQRGAGLAIITDSATNDYIANMGKLENHVGTYDTQFWLGLNDRATEGDFRWTDGSKPTYENWAPGEPNNSGDEDCAQIYVNSKEWNDAGCSSAIWHYVCQLNYDVDECANGLDNCDPNASCTNTPGGFTCACNAGYTGDGTTCTADDTFLCSDGQTIPKEWACDRTVDCPGAEDELNCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGT0</accession>
    <name>A0A914BGT0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075093.1">
        <property type="nucleotide sequence ID" value="XM_038219165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075094.1">
        <property type="nucleotide sequence ID" value="XM_038219166.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075095.1">
        <property type="nucleotide sequence ID" value="XM_038219167.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219165.1">
        <property type="protein sequence ID" value="XP_038075093.1"/>
        <property type="gene ID" value="LOC119742911"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219166.1">
        <property type="protein sequence ID" value="XP_038075094.1"/>
        <property type="gene ID" value="LOC119742911"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219167.1">
        <property type="protein sequence ID" value="XP_038075095.1"/>
        <property type="gene ID" value="LOC119742911"/>
    </dbReference>
    <dbReference type="GeneID" id="119742911"/>
    <dbReference type="OMA" id="WEACERM"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF4062" evidence="6">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="5">
        <location>
            <begin position="375"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="7">
        <location>
            <begin position="621"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1546"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1630"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1651"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1684" mass="188169" checksum="60EABD0DDF1A9F1F" modified="2023-02-22" version="1">MADSNYPEGFEWLVQGKTTKLPSQDSNVVRVFLSSTFTDTIHERNRLLKDVFPELQKYCQGKGLDFEVVDMRWGVRDNATADHLTSALCIKEIETCKRLSMGPHFVGFLGNKYGYRPLPPVVESAHFEKLACSVQSLGVEPDESQLLANWYVQDTNATPPVHVLQPITSRLPNFYNAEQPELQQKERDDWWKTFGRLQRLLQRGARAAVKEGLITEEESAVYFESVTEIEVREGLMGVVDPSASCLFFLRDLEGLGVKMEDEATRRYLDIDEDGSVDSNAQTSLKNLKTNYLPSILGEEAIHRFSLPWTPSGIDPSHPVHAQYLDDICNRFRDGIRGMIDRSLEQRSKVTDQAVADVYEELLHHAEFCDRKCSVFHGRQELMTNIRDFLSLKPGRPLVVHGVSGSGKTSVMAMLAKNACDWLKQEVVVVLRFLGTSGQSSGIHAVLQSVCRQICYAYNLKQPCSTTLGDYTDLTKLFRKLVATVATPEKPLLLIFDSVDQLSAANDAHAVNWLPMSFPSHVLIVASMLSLDEHRCQEKMRLLLADDSCYLEMQPVPQETGLEILNSWLEVKRRKLTEEQLIKVSEAFSKCPQPLFLKLLFENVLQWKSYTGMSSERMLPTSVREAITNLFEELEHKHGQIVISHALGYISAAKSGITEAEIEDVLSCDDEVLNDVYQYWDPPAENIVRTPPSLWKRIHYDVNEFLSERQSGGKTVVAWYHRQFIEAADDRYLIKEEIISARHQLLAEMFLGSYSVGKVRPITLHKRSKVFPEADRQVAPQPLEFSNGVYNRRKLIELPHHLAEAGMLEELVSHVLCNFNWLLTKLVSFSFLELMLDFRPLTEEIIILIETMYLASSNLKVDPFSLAGQLIGRIGDYGSKYPNLEKLIQQAKDWIRSTKLPVFVPSAPCLIPPGGPLRTVFGGHPSLVLRVMCTPSGELMLSACLDSEGHPMFNVWNMSTLEVVHNLQKKNDKSPLVKNSKVNMCISQSSRYVIFGKNSLALFDLVTGECLRELDTDGLTSFSNLTFDEKDSRVFACAEPGNVVCIWSFADGQKIASMQHPAEAIFITTLSSGEDLLSVCRDGKLRVWSLKSQECVMCQTGYDEGKVVACAALTPGANHLVTGSSDGLIKIWSVPLTLPSSAESITLESEITVSVKEPLLSIVPHSDTTFVLRDSSSISRIIHLVPERDPTVLDLKGHDGLITCVWTHQGVAGDGDRPSFVVTGSKDDTLKVWSLDDGRCLNTLKGHSSWISDVTVLTMEDGPRVLSACNDKTVKMWIPTKGEVTKRDRHELSVLCNALFKGTSSLIGVSGSKDKQTKFWNLDDARCFKSVSCASVAMEILEPQEMVVCGTDTGEVVAFQLETGSEVWRWPLFKKSIAVIALAARQTVLVCSKEPSDKSIRVCDGANQLEEKFRLVGHAEATTILRSVVGEENPMYLSASKMAGEIKAWDDVMGNCLTTMMHEQVMSMEVSPNSKFLATGSNKGTVKVWSLGRTSLGSLMAELTGLYNDTIVCLAFDRENRYLVSGAHTGQDQLLIWDFQGNKKRYLVGHTHAVMSVSVTVNNKYVFSSSRDCTIKAWSLESADLLASFDCQSQVKFFKFVEFAEDHYRFIATNQSGTIAMLDLLLEKAERGKKDEQGTRQSMSLPPPRSEVNGNASNESTPHTNGWNDKGNKRKKKMSKVCVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGX7</accession>
    <name>A0A914BGX7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beclin 1-associated autophagy-related key regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075145.1">
        <property type="nucleotide sequence ID" value="XM_038219217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGX7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219217.1">
        <property type="protein sequence ID" value="XP_038075145.1"/>
        <property type="gene ID" value="LOC119742944"/>
    </dbReference>
    <dbReference type="GeneID" id="119742944"/>
    <dbReference type="CTD" id="22863"/>
    <dbReference type="OMA" id="DLGRYGH"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097629">
        <property type="term" value="C:extrinsic component of omegasome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097632">
        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035032">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035014">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016240">
        <property type="term" value="P:autophagosome membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664:SF0">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56818" checksum="FAABEA0787B79343" modified="2023-02-22" version="1">MTLAMDGFDSGEKAENFQNEFPIIAPPFGGLLIAVERCPLCERTKKPFTCQKCVEKGDFVHSNSCGFGKNSERFSDKLHRLHHLRKERLDIFEKVSKKLDRAVSIAAKKWEISMLKDRLELMQKALEESKERCLADKASKTSQSAKIKDKVTTARNHMIKLERTTKCIDHGKTVLGSRQAELAGCEKRLSELRRSNVNQLTTYIFTINEIHTGDSRPADAEEESDRLVADLAEARQLSYVQGRWIETENSHEVQYSLVHPSAVCVPANGDYTAYSAWVAAKENANQGTDTQLDLSNPGKVLSGALCHTAQLVSLLTYYLGIVLPKKCPFSVFCGEQLSSHDFYKAVDKLNTNVLYLCFSQNVDIECLHPHYTVRNLLALLSPSNVQLGRNGPIDMTDVHADLLLSVPRTSHISLTSESESASESLSHLMDEDSDTSGDLEWENVLDSQVPTLTGNPSTATSPLPESVASFQQDGSEDDGAQLGETVTEGSPAGAAGGLMSSAAASVVSFWRAATSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHR2</accession>
    <name>A0A914BHR2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075411.1">
        <property type="nucleotide sequence ID" value="XM_038219483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219483.1">
        <property type="protein sequence ID" value="XP_038075411.1"/>
        <property type="gene ID" value="LOC119743124"/>
    </dbReference>
    <dbReference type="GeneID" id="119743124"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="25977" checksum="18C756D38F194196" modified="2023-02-22" version="1">MSPMFCSQTRICWKRKTWGRASANYQLTLMRSRVKSTTPYTRSMPTTDPPGTPPRSYTTRCRHCPLRCRLSAIRSRLNNTVTPLWNQPYEDQLSTKQTNTREFLRNLSKMLQRNIGEMPPWLKQERKNHSGMECELEPIKPSPELESYRNKCEFTIGKSVDGIGLDPQDNHSTSTSDVPVTGTAIMDPYHYLTQQHFTSEIFKIEILNLPRHVGFVLVQPVTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI81</accession>
    <name>A0A914BI81_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075993.1">
        <property type="nucleotide sequence ID" value="XM_038220065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220065.1">
        <property type="protein sequence ID" value="XP_038075993.1"/>
        <property type="gene ID" value="LOC119743910"/>
    </dbReference>
    <dbReference type="GeneID" id="119743910"/>
    <dbReference type="OMA" id="GDETNIN"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Apple" evidence="16">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="363"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="468"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="388"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="493"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="570" mass="59973" checksum="7720ED4098D0A261" modified="2023-02-22" version="1">MASNAATLPYAAAAACIVIAVLPWIHGIESYWGHRSFKVHCEKGIRLGGGDAGLGVSRKTSSKAQCLRSCFARAECKSISYSPKTGQCYMSDSTKGVAGTSQDEGYVYCGPDQDEVWERTAITVELPTTTLMPTTLEPNECDSDPCQNGAACNDGPDMFTCDCAPGYEGTTCNTNTDECGSNPCQNGANCVDAVNEYACTCLAGYDGVHCETNINECASSPCQNGVCNDGVNSYTCTCSAGYEGTLCNTNTNECASSPCQNGVCNDAVNSYTCTCTSGYGGTLCDTNINECASSPCQHGACNDGVNSYTCTCSAGYEGTLCNTNTNECASSPCQNGVCNDAVNSYTCTCTSGYGGTFCDTISIRLVNGPTSNEGRVEVWHSGAWGTVCDDFWDLNDANVACRQLGYPYATNAYISATHGAGSGPIHLDDASCTGTEVRLGSCPHNGWDVHNCNHNEDASLKCYPGTRIRLVNGPLPNEGRVEVYHNGAWGTVCDDYWDINDGHVACRQLGYPSAAQILNWAHYGAGTGAIHLDDMMCTGSEASLGACSHRGWGSHNCGHSEDAGVKCNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKR8</accession>
    <name>A0A914BKR8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038076519.1">
        <property type="nucleotide sequence ID" value="XM_038220591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076520.1">
        <property type="nucleotide sequence ID" value="XM_038220592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076521.1">
        <property type="nucleotide sequence ID" value="XM_038220593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076522.1">
        <property type="nucleotide sequence ID" value="XM_038220594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076523.1">
        <property type="nucleotide sequence ID" value="XM_038220595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKR8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220591.1">
        <property type="protein sequence ID" value="XP_038076519.1"/>
        <property type="gene ID" value="LOC119744588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220592.1">
        <property type="protein sequence ID" value="XP_038076520.1"/>
        <property type="gene ID" value="LOC119744588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220593.1">
        <property type="protein sequence ID" value="XP_038076521.1"/>
        <property type="gene ID" value="LOC119744588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220594.1">
        <property type="protein sequence ID" value="XP_038076522.1"/>
        <property type="gene ID" value="LOC119744588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220595.1">
        <property type="protein sequence ID" value="XP_038076523.1"/>
        <property type="gene ID" value="LOC119744588"/>
    </dbReference>
    <dbReference type="GeneID" id="119744588"/>
    <dbReference type="OMA" id="KCSGYCN"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035523">
        <property type="term" value="P:protein K29-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990168">
        <property type="term" value="P:protein K33-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22766">
        <property type="entry name" value="OTU_TNFAIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF3">
        <property type="entry name" value="TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="17">
        <location>
            <begin position="107"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="18">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="18">
        <location>
            <begin position="1125"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="542"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="891"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1157" mass="128361" checksum="19DC39A315840A35" modified="2023-02-22" version="1">MSPKDRADQAEQRSPLRLPNKISDASPTITSQLRCSIKEEIEEHRQDDTLTRFFLQMATFTSLLPPHWESYPSDLKMFLEKEMFDPVLGHILQSEGLMNWCPSVRKVYPLITPGDGNCLLHAASLAMWGIEDDELVLRTALFRLLRDDRNERNHMRWQRERMRADAGIPGSGLMYNTTEWDSEWDLIKELASPKRRPMTAHGLPYESLEQFHVFMLANMLRRPIIVVAQDMMRSQWGHSIQPQDVQGIYLPLNWDPAVCCRYPILLGFHQNHFTPLLCTAKLDSEDDLDNYLFPIVQQDYTPMKVHFLEEEEEKFVDSLLQKYLIIEEITHIGKSLSRAQELPGARLVSQNSHPDLDLMIPYLALAETHYRHYLEGEYGNTVESTPAIEARGKADVALGKDPQKLQSLQEQPRSFPSYSIPTGPQPGKTSWSGQGAPVGQPSDATHNAGFVASKNLPYKREFSLVEQSCKTEGCVYYRSVSTGEYCHECSQKQSQGNKCQGEGCLNPAEQGCQGLCRVCFDQKKLTEDPMVNATAPSLSKMSLDPNVNVGPSKRDVDSRYWYGKGDDGQNPGSNIPTEQGQMPPHLGVSSTGSAGLAVRRKEPVLEKAGPTQGLAKSPDNELNSMIVHQKLPTKKCIMPECPLTGEPTKNDMCSKCYAENLQVEQEIEKSKMHRQPATVEPPAYSALATAACAASSSASALPQASAAAAASGKLLYPEKKPTFTVQKSICATAGCSGIRLDKPPYNGYCISCYNQNNNIPNQATTAEVRNLGISKNQVNPNLIQNGRSQDQFRPTGPRGIDKYYSTAPQAKQAERRSGEAHQPLIYQAAAKVETTTESPAPQCAGRRCNNLAAPPKFILCEECIPIAELYKQEGTGGSVDKEAVRSAALEPQPAELNQPNDAAKQVAEPPGSTPSLLSKTAAGFKNIRVQRVKCQVPGGCADDMYGDPALNNLCSRCSAKMLMRRTRTRASPPLNQAEPRPTQSPVHQYHTAPLSPSPRIGQVPPRAQTEFLYAGPERGQRELGIQKRHTLPANFQKCAQPKCPNQANLQILDGLCNTCHRVYRNQGYAPEPLPINPDPLVGNRGRYAQPMVPEAQFYPPGYSSREEKILNIESGPRIPPRPERNRTDMGCLSEGCTNYGNPRCQGYCNSCFRLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLJ9</accession>
    <name>A0A914BLJ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076984.1">
        <property type="nucleotide sequence ID" value="XM_038221056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221056.1">
        <property type="protein sequence ID" value="XP_038076984.1"/>
        <property type="gene ID" value="LOC119744871"/>
    </dbReference>
    <dbReference type="GeneID" id="119744871"/>
    <dbReference type="OrthoDB" id="6160241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052580">
        <property type="entry name" value="Lipid_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394:SF1">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="123" mass="13181" checksum="8F129F16B1939880" modified="2023-02-22" version="1">MSTLGVKSPTRLKSPVAYSSVAASSELLTVRQKDEFVGYDFCFDTIVFEGGGNKGLAATGAIRVLEELGYWGNIKRFAGASAGSMVAALASVGYNSYDIETFLRGDITKVFLARQAWLHGFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMB9</accession>
    <name>A0A914BMB9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076617.1">
        <property type="nucleotide sequence ID" value="XM_038220689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220689.1">
        <property type="protein sequence ID" value="XP_038076617.1"/>
        <property type="gene ID" value="LOC119744641"/>
    </dbReference>
    <dbReference type="GeneID" id="119744641"/>
    <dbReference type="OMA" id="VDWLVIE"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF48">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037043158" evidence="3">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="338" mass="36992" checksum="D910DA85C5FBE853" modified="2023-02-22" version="1">MVSWLVIIAALVAFAALVVSLMDRVYLDVTGRYVLVTGCDSGFGNILAKYLGRKRGCHVIAGCLTRAGMEDVMSGAPKGTVTAIQVDVTDTKSILQAREEVVRIVAGKGLWGLVNNAGVTGSPGPFHWHKKREIQRILDVNLMGTIEVTNVFFPLIRQGRGRIVNVSSATALLPMRAGGYSISKIGVEAFSDTMRMSSKAFGVTVHILEPGHFKTNLTSVDGMLASAERIWKRLPPQERDIYGQEYFDAMKEKTIHHLEKSSPKLHLVTDAMEHALCACWPWRRYLPGNDVKLLYKPLSMIPAGVTDFILGLLGKLPVAQPRPTATVTFATDSNDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMV5</accession>
    <name>A0A914BMV5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076802.1">
        <property type="nucleotide sequence ID" value="XM_038220874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220874.1">
        <property type="protein sequence ID" value="XP_038076802.1"/>
        <property type="gene ID" value="LOC119744762"/>
    </dbReference>
    <dbReference type="GeneID" id="119744762"/>
    <dbReference type="OMA" id="ISHWFKR"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="65940" checksum="BB258B57D88D42ED" modified="2023-02-22" version="1">MGRFRRSSSTGMEIDMDKLRQRRASAFIVPQDGGWGWVVCLASLWTNGTIFGIINSFGVMYEKIYEEVEGANNFKTSWAASLCSGLTFMLSPISSILTDRIGCRAAGIIGGALACGGMIASSFVTRIELLYLTYGVMSGCGFSIAYTPSLVILGRYFRRRIGLANGIVTFGSGVFTIVLPLGLKATLETIGLSNTLRVMAGLCFVMMLGAIVFRPVPLPANFDMKLLESLAESAPRGKPSLRNLFGLLDFLDLRVWKKRNYRIWAIGVPVAVLGYFVPFVHLVKHVNNLNLGGNAAILITCIGATSGLARLVFGKIIDSPKVNRIYLQQIAFLVIGVTSTLLPVVRNFYALCVMMSIMGIFDGIFVLLIGPIAHDVAGTEDASRGLGFLFFMMSFPMTAGPPIAGFIYDKLQDYTLAFLLAGAPPIIGACILFFVRPESHDADSDDDDTPSDDRSSEDDLEQSRKLLNSSSDTDEFWQTSPYARRKFLELRNAWSPPPPCLKPPSNLTPRPILSTGSNRPKTNGLPRNVSAPAMFTFDLESTPLEGVSETPPPDVDVDVNERFLRSGRRVTYGDVVYHGEVSELRPLPDPDRLFIEERVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNA3</accession>
    <name>A0A914BNA3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076957.1">
        <property type="nucleotide sequence ID" value="XM_038221029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221029.1">
        <property type="protein sequence ID" value="XP_038076957.1"/>
        <property type="gene ID" value="LOC119744854"/>
    </dbReference>
    <dbReference type="GeneID" id="119744854"/>
    <dbReference type="OMA" id="SLMTTNQ"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037356854" evidence="3">
        <location>
            <begin position="29"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="38195" checksum="C1101B8841615735" modified="2023-02-22" version="1">MKGRTQLLVLHVLATLLVLLIYATLASATQDSGTPPTTTSTERLTTTQEAMASTKEPPVSTATTPLNSESMTTTIQSNVTIPMQPEAPSTTPAQSTTGLTNTTQNSSESLMTTNQPNVTNPMPPTTAPEPPPMTPAQFTTDLTNTTQNSSESLMTTNQPNATNPMPPTTAPEPPPMTPAQFTTDLTNTTQNSSETLMTTNQPNASNPLPPTTAPEPPPTTPAQSTTGLTNTTQNSSETLMTTNQPNVTAPMPPTTSPEPPPTTPAEAKVTTAMPQSTSSPESPGLSGGAIAAIVLSVLLIVLVLVVGGVLWRRKHARPDDLTMPLAEEWTTPDGFESRYQPDADENRPLVEGDITCSLTDATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNT6</accession>
    <name>A0A914BNT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077371.1">
        <property type="nucleotide sequence ID" value="XM_038221443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221443.1">
        <property type="protein sequence ID" value="XP_038077371.1"/>
        <property type="gene ID" value="LOC119745219"/>
    </dbReference>
    <dbReference type="GeneID" id="119745219"/>
    <dbReference type="OMA" id="CESNCEF"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="458"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="593" mass="68506" checksum="1875174C61D65C31" modified="2023-02-22" version="1">MSLTGRPWIVINKVSPLDPRPEERVGHAGGRGKSDRHVLEVDGDVQADRARSELDVLQSLTSLPATATAPRPRRSSVSATLGAAFTRENFFHAAEKDFVKKIYRSEKALKEEQQRQQDIKSFVIHPFSNFRWYWDLFMVLLMAITLVILPINIAFFSEDFSLQWSITNCVTDSFFMADIVLNFFTGIVHHQNEEVILDRRTIACKYLRGWFLIDLPSSFPMDYFYLLFRGDSDYDQTALKLRAIRLAKILSVLRLLRLTRLLRYVHRLEEILNVEGALIRITNLVLLVLVIIHWNGCMQFLVPFFQGFPRDSWVVISGLENASKWEQYSWSFFKAICHMLSIGFGQHPPHNLTEMWCATLSMMIGATFYALFIGNMSTLLLSIDASGRIYNEKICQVKEYMRYRKIPASTQKRVLMYYEHRYQRKYFDEDAILRQQSAPLRREIVQHHLRSLVKKAEFLSKGSPSFVIDIIEKLHFEVYLAGDVIITAGSRGDAMYFIEHGMVEICVNNRVVGTLQDGDHFGEISLLIDERRVASVLAASTCDLYRLAKDDFEEVLEENPEMRAIMAEVAKERLRKIGTPSKDEEDKEIALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP28</accession>
    <name>A0A914BP28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nibrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077247.1">
        <property type="nucleotide sequence ID" value="XM_038221319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221319.1">
        <property type="protein sequence ID" value="XP_038077247.1"/>
        <property type="gene ID" value="LOC119745093"/>
    </dbReference>
    <dbReference type="GeneID" id="119745093"/>
    <dbReference type="CTD" id="4683"/>
    <dbReference type="OMA" id="IVFGAMN"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000017">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10980:FF:000001">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013908">
        <property type="entry name" value="Nibrin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08599">
        <property type="entry name" value="Nbs1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01348">
        <property type="entry name" value="Nbs1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="784" mass="86642" checksum="1868512F28736C0D" modified="2023-02-22" version="1">MWLLENIRVPGDSFYLLEGQNYTVGRKDCKILVLNDSSVSRKHATLTVTYSDASLSKPEIKPVLTLIDSSKFGSLRNGSKMGIGSNTNLEDGDLIVFGAMNSNQWKVTYKPLVVAFSSLPSADKRSLKSLIRKLGGHVVPEWSKECTHLIMTQLTVTIKVIGALVTCRPIVTPEYLRKLEGAACNNTPMPDPSDFQPVIAETAIKEDDVSFQANTHRKTLFQGKTMMFLAQKQFKQLAQTVKLAGGKALLVEEGVTSREEDLLVDPNTLVMYADPQDQSQVMTQAGQEWVTEVMELLKRNGLRPIPQSEFGLAVLYASTKVHCNPRVAQAGLTFIHPVAAPSLTTQDVLASETQLSEMARPHPATRSKPNASKSALESIDQKEKTDKIADKSGHTPSKKRLRDDDTANFTSPAKVLRREPGKSNKPPSTPETVPQTARTNGGPVPGTSPELPYIGKPASRLGEQRPGGFVDCKDKAQESSKVSSDAKKQDNVAVCTRNRLSRNPLKGRKRYKTAGIDDSAYPGSSIDDDIISPSERISEGRSKIKKEIESPNSHRGDPACTYLDPVKETVESIIDETEDSVIPPSGVSVRGRRLGGRVQDLVVMETDEVREDEDRGAEQGMWKKRTKKSRHTEEDNQVNDEMNADSSSRRTYPAQVIPTGYITANKTIKSEPTSPQDPSLPVDVAVVEQVALAIRRPAVNGTRSTAGRKGVNNFKKFKKASYAGQHSMPRIIGGSDLEHHGIGHIREAEEMMERERETLRKRHKEKDLADQLFDWDPRPSKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQG9</accession>
    <name>A0A914BQG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DZF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078399.1">
        <property type="nucleotide sequence ID" value="XM_038222471.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222471.1">
        <property type="protein sequence ID" value="XP_038078399.1"/>
        <property type="gene ID" value="LOC119745843"/>
    </dbReference>
    <dbReference type="GeneID" id="119745843"/>
    <dbReference type="CTD" id="51663"/>
    <dbReference type="OMA" id="HDYVEEX"/>
    <dbReference type="OrthoDB" id="8898434at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002080">
        <property type="entry name" value="Zinc finger RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000210">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZF" evidence="6">
        <location>
            <begin position="654"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118157" checksum="94FE7A43DB167D24" modified="2023-02-22" version="1">MKVDVMYRHRTAPDLFGSFRMQITRGFAVHNFVHVQARTRTQPVTPYFSLVSSEEYIMASQNYFGFTHGGTQYTQPQQSGYAQHTAQPXTGHVYQAATPVAAHQTTYASTATPRQTQAASGYETGYATVAATHQTGQYGYGTQQRQDAQTPSPATSQTYRESYNYVQSTPAATSYEKQSYYQQPQAQQTATDSYYQQANKYGKTAATKQTAYPNTGSASAYTTHHQAAVQKPAQTKTVVTYAYAPQTTTPTYANTPATTSYTAKEPAAAAAANSYSSYDSLVYSAASSYYQQQQQGKMGGSSWGFKGGNNKPNYTQNKFVQKKDRMPPKQPQIHYCEVCKISCAGPQTYKEHLEGQKHKKKEQSQKEAPGRPGIALRCELCDVSCTGQDAYKAHLNGAKHQKVLKLHTKMGKPIPSSDPIKINTATSSAAPTMGGKTAASAPTVGAAAAKAKPLVKKIVTPKITFVGGAKLTSTTLEADKKTDVKMETSAATAETAGATAEVKDEMAEFEKEIIPVGEDYIEEIKNDEGKLLSFNCKLCECKFNDPNAKDMHMKGRRHRLQYKKKVDPSYQVDMKPTSRTRKAQEEKMRRQFAKEEFMRHREEENRWKDEIRRYEEDMYWRRMEEERYWEERRLFDEEMEFFEWQRRRGIPHPRPVPPKMPGQMDIMKRPDSEIDRHVMAKHAAVYPSEVELQQVQAMVSNCEKALKMVSDFLAEADTPKEKEEPKAEVKTEVKTEPKEDAEKMEGDGQAEKPDSTVRVLKGVMRIGVLAKGLLLKGDLNMGLVVLCAEKPTRTLLERIADCLPKQLSEVTEDKYDIKLCVEEAGLLVTSPTSKMTMKVTLTSPVMREAAADAADTAKDPPDVLDRQKCLEALAALRHAKWFQARATGLQSCVMIIRILRDLCERIPTWAPLNGWPIELLCERVIASRGQPMRPGDALRRIFEAIAGGLLLPSGPGLFDPCEKDPTDALAHLDKQQSEDITASAQHALRLIVFRQIHKVLGMEPLAVEQRTPNRGFRRKRRHNESEGGEDSEGKKDKKDDASEDKMEAAEVAPEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT10</accession>
    <name>A0A914BT10_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079319.1">
        <property type="nucleotide sequence ID" value="XM_038223391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT10"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223391.1">
        <property type="protein sequence ID" value="XP_038079319.1"/>
        <property type="gene ID" value="LOC119746437"/>
    </dbReference>
    <dbReference type="GeneID" id="119746437"/>
    <dbReference type="OMA" id="TEYATEN"/>
    <dbReference type="OrthoDB" id="5971555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="454"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="633" mass="72026" checksum="FC4D6FF02A97263A" modified="2023-02-22" version="1">MSDEDRIKIALNDSRILGLNAADNDALGELFTEFFSSDNHGDASDSHDGASDRESSDSDSDAGGHWKESASDGENDIDNAEEPMDVDDNDDLEPIVVENVAANIIQDIGMDDWVSPDAEEELEKVRNFNKCRCRNHQCLQKFDSGFIIKLRRQMSDATLTKSEKKMFLLGKLSTTLNNSQTTNCKKRPRQKVRQRSRTEYLVEGVKVCREAFQFMHNVSNNLLTSLAKHYKHEGAAPHKITSGGRRFNTRALTVKDIERVVQFISSYAEEHALVIPGRVSGVKCQDPRVRLLPSSETKSSVWRKYQTYMGDMNSTRRLSGDPDFCIVKRVTFTKLWCQYCPFVLTTRPKTDLCWVCQRNNSLVYQSANQLDGEKLAQLRRQEEHLRVVNMERDLYRSMVADCKQAVGEEHLGLHQPASRRGTAHYSFDFAQQVHYPHNPNQPGPMYFLCPRKCGIFGVCCEGIPEQVNYLVDEGMSSSKGSNAVLSYLHHFFLHYGLGEENVELHCDNCSGQNKNNFVMWYFVWRTLHGFHDNVTVNFLIAGHTKFSPDWCFGLLKQRYRKCVVSCLGDLEEVVRTSTTSGVNIPQLVGTENGTSSVSLYDWQAFLKPFFRTLPGIKGYHHMRFSKDDPVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT12</accession>
    <name>A0A914BT12_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079438.1">
        <property type="nucleotide sequence ID" value="XM_038223510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT12"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223510.1">
        <property type="protein sequence ID" value="XP_038079438.1"/>
        <property type="gene ID" value="LOC119746528"/>
    </dbReference>
    <dbReference type="GeneID" id="119746528"/>
    <dbReference type="OMA" id="RRIEMAG"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000176">
        <property type="entry name" value="pancreas/duodenum homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF18">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="35188" checksum="38991A92A9126FD0" modified="2023-02-22" version="1">MHSSFYDTAQIAGEFYHGATATESTPAACRSTSTNDGFCYAQNPRYYNMYYNSSAGAGEGYPHHHPASEPVSIPGLSVPPPPSAEQGCYGNILSEAAATSATRSHRPPSNGSSDSAEDEEGIGGEGLKTESSSRGHGGGHSKKIYPWMTESRQNVKQKVTSASEKKKQLEIAASKRNRTAFTSAQLVELEKEFHFNRYLGRPRRIEMAGSLSLTERQIKIWFQNRRMKYKRDAKESERAERGIKVSDSVLARQSERSPRFIAATGSPLMLNYPGSAGGGGGMTAGAASPCMDTRNFPHGGGIYNRFAYPQEQLMNASPRLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTZ1</accession>
    <name>A0A914BTZ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079217.1">
        <property type="nucleotide sequence ID" value="XM_038223289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223289.1">
        <property type="protein sequence ID" value="XP_038079217.1"/>
        <property type="gene ID" value="LOC119746377"/>
    </dbReference>
    <dbReference type="GeneID" id="119746377"/>
    <dbReference type="OMA" id="ETCMSMA"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20403" checksum="2BF345D52688C4D0" modified="2023-02-22" version="1">MKRYADGHQMLNIKHVAVRVQNSQEKIYILQTVRYPNVLGLSKMLGLSLAVCAGLCAACASAFAKLAMSGEEIALVCQSLEESVAMGTLMPNCSVVTTVLRGISFSLLFLFNAIMWTLFVKSLQLARSSLEATITNSSANLFFTAVIGYVVFGEALSLTWGLGSTFIILGLWMIHRGGRTKDEVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXK6</accession>
    <name>A0A913YXK6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044102.1">
        <property type="nucleotide sequence ID" value="XM_038188174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188174.1">
        <property type="protein sequence ID" value="XP_038044102.1"/>
        <property type="gene ID" value="LOC119718765"/>
    </dbReference>
    <dbReference type="GeneID" id="119718765"/>
    <dbReference type="OMA" id="QDAFDKW"/>
    <dbReference type="OrthoDB" id="6157104at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF293">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="511" mass="58259" checksum="B1A8583498D2F5CD" modified="2023-02-22" version="1">MDAWYDAKDTTPVILKIKYQHAQGGADCSNSSALPQGSAMGSVLSSVGVQDQMTRPTAQGGETFAVRLTEFGDATTYHGLRYVINNKYSRFRRFVWLLVVLGMATWLVVNIIKLTLLMLQHPESSSISLNYVPTIAFPAVTICNINLLRSNALNESVLKTLAEIYDPVTDYHQEGTGVDFGPVDALYHYPNGSDSTETIFSASHQIEDMLDRCKWRHEKCSPANFTQRLTDHGVCYTFNDPPDERDVLQVSNPGSSNGLYMRLNIEQDLYTYGESTSAGMKVMLHKQGEFPIVKEFALSLTPGYEISIAVRKQMVKSLKAPFKSNCTTSSHLREFPYKYSVPACHFECMVRFVVDHCGCRDYRWPVKAPICSVEKQVTCVYQYEDEFVWDSDKCSCQMSCETLTYESTMSQSFWPAKQIDRDLREKYGFSRDFIRENYMEVYVFMEEIMYMEIQQQEAYTLEHFEGDIGGYMGLLCGMSLITLVEWLDFIVITLYKRFGCSKRNRSGDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZJ7</accession>
    <name>A0A913YZJ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044822.1">
        <property type="nucleotide sequence ID" value="XM_038188894.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188894.1">
        <property type="protein sequence ID" value="XP_038044822.1"/>
        <property type="gene ID" value="LOC119719438"/>
    </dbReference>
    <dbReference type="GeneID" id="119719438"/>
    <dbReference type="OMA" id="VQMPTEV"/>
    <dbReference type="OrthoDB" id="10685290at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="4">
        <location>
            <begin position="3847"/>
            <end position="3940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="784"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1438"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1494"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1877"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2128"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2331"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2401"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2496"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2685"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2832"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3135"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3242"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3323"/>
            <end position="3342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3411"/>
            <end position="3433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3482"/>
            <end position="3573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3592"/>
            <end position="3612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3653"/>
            <end position="3687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1877"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1913"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3482"/>
            <end position="3546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3553"/>
            <end position="3573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3955" mass="416497" checksum="008B1324C8171365" modified="2023-02-22" version="1">MTTTAVQTTTPKATTTKETTTVKVTTEATTTEAPTTLERTTTRVITTAAPTTTGQPTTTEEVTTTVVTTTPEATTTETTTVQSTTEAPTTEETTTAVFTTTKTTRAPTTTAAPTTTEVVTTTAVLTTTPKATTTEETTTVRVTTEATTTEAPTTVERTTTRVRTTEAPTTTAQQTTTEEVTTAVVTTTPEATTKETTVIYTTTVAPTTEEVTTTVVTTTQTTKAPTTTAAPTTTEVVTTTAVHTTTPQATTTEATTAVKTTTEATTSEAPTTVERTTTRVTTTEAPTTTAKPTTTEEVTTTIVTTSPVETTKETTVIQTTTVAPTTEEATTTVVTTVQTTRAPTTTAAPTTTEVITTTALQTSTPKATSTEETTTIKTTTEVLTTEVPTTVERTTTRVTTTEAPTTTAKPTTTEEVTTTIVTTSPVETTKETTVIQTTTVAPTTEEATTTVVTTVQTTRAPTTTAAPTTTEVITTTALQTSTPKATTTEETTTIKTTTEVLTTEVPTTVERTTTRVTTTEAPTTPAQPTTTEEVTTRVVTTTPEATTKETTVIRTTVAPTTEEATTTTVTEERTTTVVPTTQTTRAPTTTAAPTTTEVVTTTAVQTTTPQATTTEETTAVYTTTEATTTEVPTTVERTTTRVTTTEAPTTTAQPTTTEEVTTTVVTTTPEATTRETTVIQSTTVQTTKPPTTTTVTTTEVTTTPTTAAPPTTKRTTVVVTTTPEATTREETTIVVTTAEATTTEAPTTVERTTTRLTTTAAPTTTAQPTTTEEVTTTVVTTTPEATTTETTKVQTTTAPATTTQEPCSDNLDTYDLVDVQRETSDNPGFQVQPTYWWTPASPPTHPSNPYSGSHLTAEFTPRAVVTSVVVLREDGAVERVKIAIVVRYNKGSSFTSLKGENNERLFVGFTGSKIHVPVDTPAVASMAVFIFDPPTSVGFRIIFHGCEGPVETTTEVATTARTTRVTTAPPTTTITTTTVVTTTPKATTTEETTAVVTTTEAPTTEVPTTTERVTTRLTTTEIPTTTAQLTTTEEVTTTVVNTTPLRTITETTTIQTTTEAQTTTERTTTRLTTTEAPTTTEAPTTTEAPTTTARPTTTEEVTTTVVTTTPEATTTETTVFQTTTAPRPTTPEECADNLDEIVDIQRTTKEDPDVNRPPTYWWNPPAPPVNESAPYDGSYLTAEITPRVRVTSVIIASDVDAMTEVKFAVEVQYIQGGPFTEVKNGEASLFVGETDTKIHLPSDLSYVSAVRIYILSRFPSASFQIRYNGCEETSTPRPTPPEECADNLDEIVDIQRTTKENPDVNRPPTYWWNPPAPPVDESAPYDGSYMTAEFTPRVRVTSVIIVSDIDTMTEVTFAVEVQYVQSGPFSEVKNGETSLFVGETGKKIHLPSDLTYVSAVRIYILSRFPLASFQIRYNGCEETATTVKTTTQVSTTEAITVSPTAPAPTTTSRTTEVVTTSPIATTTERTTVRVTTVPSTAAPTTAVITTEKTTTEVATTSQTAPPTTSRRTTSVVTTTPQVTTATQATIPNCYPLEYDDCACLRTCADEQRPVCPEPGSPQCTPACSCPRDQYWDDDLGACVDECNCTEYQDHKDDDYWFQSECIECKWVDKDLCKVSCGEMCPLKPSDCDADEELVDEMKDDGKCCHCIPIERCQYEGDDYDVYREPGEVWYPEKCMRCECKESGNVICQTFVCPTPQCTDPINDPHVCCPYCPPTTTPIPPTTAVQTTTQQPTTTTPVPTTTGSKYCPDYCHIPDKIPCEDSQFYFGGNLPFKPDIRCEPGFPFSVDPDCECKEGYYKDGDEFLQHFWFTYGTSMCLIVERPCDCLDETTDTYYGVGDSFIRGDCELCTCVLMPSGYDLMCFIDGDLPNCTLTTTAETTSAPPPTTTRAPTTTRAPPTTAGTVPTTTPATFPPTTPKPPCSDQCYGEPEIPCDKQTYDYYLANGFPPFSVVIFCSPFIVGPENGPTIPNYYADCDCGEGYYRDYDNFDDEKSLLSELGFSWETYMCVELEKPCQPPGPCPFNETLTLQPGESIQQDCSICTCELKGGSTTGRYELICDPIPGCTTTPGITTTIVTTHITTPIQTTSKQTTAVQTTPVMTSIRTTPVQTTTPIKTTIQTTTPLKTTTPFITTTPIRTTKPPSSLAPTTTAAQTTTTARTTTAAQTTTGAHTTTAAQTTTEAPTTTAAQTTTAAHTTTSAPTTEAPTTTEAPTTTAAQTTTPFQTTTEVPTTTAAPTTAATTTAAQTTTATEAPTTTAAQTTTAAQTTTAAHTTTAAPTTEAPTTTAAQTTTAAQTTTAAQTTTAAQTTTAAQTTTEVLTTAAITTTAAHTTTAAPTTETPTTTAAQTTTAAHTTTAAPTTKAPTTTAAQTTTEVLTTTAAPTTTAAQTTTEALTTTAAHTTTAAPTTEAPTTTAAQTTTAAQTTSAAQTTTAAQTTTAAQTTTAAHTTTAAPTTEAPTTTAAQTTTEVLTTTAAPPTTAAQTTTEALTTTAAHTTTAAPTTEAPTTTAAQTTTAAQTTTAAQTTTAAQTTTAAQTTTAAHTTTAAPTTEAPTTTAAQTTTEVLTTTEAPPTTAAQTTTEALTTTAAHTTTAAPTTEAPTTTAAQTTTAAQTTTAAQTTTAAQTTTAAQTTTAAHTTTAAPTTEAPTTTAAQTTTEVLTTTAAPPTTAAQTTTEALTTTVAHTTTAAPTTEAPTTTAAPTTTAAQTTTEVLTTPAAPTTTAEQTTTEAQTTTAALTTTAAHTTTAAPTPETPTTTATQTTTAVQTTTTAQTTTEAQTTTAAPTTEAPTTTTAQTTTKFLTTTAAQTTTAAPTTEVPTTTAAQTTEVLTTTAASTTTSAHTTTEALTTTESRTTEAQTTTAAPTTTAIITATAYCLTPLMDLGLVEMWVISDDAGTSIPLEDPTDPWKVDNILEWEIIEATLRYWAQIRGIKILGQVSEPMEVTLSYSVNRTQILMPLDLHIDLLKDTYVNIIFDEPLRFVTDLQFKLKKYPTTATAIQMDYLGCVEPVRPPEPTTAVSVPTASTEAPTTSVTTEVITTEETTTEIVTTTAATTTPEATITEKTTVATTTALTEVPTTARTATTTVTTRETTVIPTTTAAPTTTLETTTVVLTTTPEVITTEETTTVVATTEATTTEAPTTTESTTVRVTTTPAQPTTEQQTTTEGVTTTVVSTTAEATTRQTTEVQTTAVASPTATPETTTTVVTTVSTTVAPTQTGAPTTKEEVTTTAVYTTTPIAKTTEETSTLRTTTGPTTTEAPTTTEARTTHITTTVAPTQPTAQPTTTEEITTSIVTTTPEATTTEKTTVRATTEATATTVVTTKATTTAPQTTTAPRTTEEVTTTAVYTTTPEATTTKETTTALITTGGTTTEAPTTTEATTTRVITTEAATTSATPPTTEEVTTKVVTTTPEATTTETTTVKSTTVAPTTEESTTSVVTTVETTIAPTTATSPTTTEVVTTTVVQTTTPKATTTEETTTVRATTEGTTTQAPSTTEATTLRVTTTEAPTTTAQPTTTEEVTTTVETATPRETTIETTTSETTKVPTTTEERTTVRTTQQTTTVPKTTSAPPTTSRVTTVTITTATPLVTTEEVTSTVSATTGSTAAVAPTSSEATTIRVTTTEAATTTAPQTTTEEVTTTVVSTTKEATTTQTTTVQTTTVSPTTEETTTSVHTTQETTTVPTTTEAPTTTKEVTTIIITTTPELTTTQETTIATTTEAPTTTGLVTTPGSTTVRQTTSVTTEAPTTRRQTTTEEVTTGPITTVTVRETTTEGETTTHVTSVQTTTGVHVCIQDGVEYQEGNVMPSPDKCKVRFCTANGVEDIEIVCNRTCYNGYLVETDEAHCCPICVPIEEDCFFQKYLSLVVADNCVSENEILYTDCEGKCASNSRVTTLPTSHIQFVCGCCKPDKLSINHVKMLCNNGTTHFYSYYEIESCACKSCEYYPLDYAEAKLIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z139</accession>
    <name>A0A913Z139_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045382.1">
        <property type="nucleotide sequence ID" value="XM_038189454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z139"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189454.1">
        <property type="protein sequence ID" value="XP_038045382.1"/>
        <property type="gene ID" value="LOC119719972"/>
    </dbReference>
    <dbReference type="GeneID" id="119719972"/>
    <dbReference type="OMA" id="NDNIHAY"/>
    <dbReference type="OrthoDB" id="6153483at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037426211" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="142"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="264"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="16">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="882"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1154"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131856" checksum="E1AA782A670B6632" modified="2023-02-22" version="1">MDLTLLRLLGFSILLRYVPATAEKLANSTIDLRIVGGRYPNEGQVEVRLPGQETWGSYCSVDLKWTYTAGRVLCRQLGYPTLYAISNTAEFGRATGPIWLQEIDCSETLTSLEECSLELWTPRYYGCDHRHDVGIKCLTGGIQLVDGRRENDGKVLLHLGGAEWASLRYFGTTERNRVSDYICRYLGYPFAVGPTQFQADDESQAVICNYNHCKGSATSNDFFECLDEMPLRFCRDEDKRNTSLLGVACVKEDEVLPPTASPEFRLSPPDTRWNGSRHVGFLEGRYNGSDWKTVCIHLTCLSDNENGFADRACRYHGYPRASYWEQIPSAESNHPSNGDDLILRVTYLGERRWMYGKNSCRDHNYNQIVFECDQGVTMYGLTVYPCSTQSCSGRCGSPATETQCGCDALCALCNDCCHDYSTRCHLQQQNVTEKFLLVASLHDFLSCVIVDDERAVLVQGCPTDWLDDEVELCQNDSMSEKVKYGGFFHDVYCAICYYNESCVITTKLVEYKYSRYSSDISSLEYDSENGESPDINYSSYNFGIDNCSAYNVSLAIQSGCRAYSAMVVASDGRVYKNPHCAFCNGVNFSGWDYDCSISPGCSAVLNTFILLGRIAIPWVPEQSTDFGLLSNAYCFNKQYVIRVKSSVNLHASGVKTMTQSRTSGMMQCYLIVLSQQNVQSTWPFYVAFIEGKLVSVWEDVTSEVTTLNLGNVTDFEALLDDSALPNNEESSFNKWVVRCGVAQVEFDEICGLVDDHIEPCENSLYITNEEMLKAFNFSGIQVVYVGGGLLVEAKWVSYTRSYQYQPQVQNTSAKSNTVKVCGEPFLNEECRTPLIQTTKLVSSGGASVVQYQNKLFLEGRVVYLPDDRILICSSIFTTVDPLYVVSCVSYSLSTVALVATFTTYCVFPALRNVPGRAIMGLTAAFSTAQLLTLTVLQFTEPVAFCVTIAALLHLLWLSTFAWMNVLAFDLVRTFSSKQTCRPNMRVFLVYSVYGWGLPLLIVATCLLIHFVWDQQLDFRYGVGPGEDTCWLSGQHAIVGAFVAPIACSLVANVVMFGWTVRSVHASVVAGVMVRADKSRTKEKARELWIYLKISAVMGFTWVFGCLANRINHVVLWYLFVILNSLQGVFIFVSFGCNRRIRALWREKLVAKQPRGTSDTKTRKTQSASVVSKQSGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z280</accession>
    <name>A0A913Z280_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045933.1">
        <property type="nucleotide sequence ID" value="XM_038190005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z280"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190005.1">
        <property type="protein sequence ID" value="XP_038045933.1"/>
        <property type="gene ID" value="LOC119720350"/>
    </dbReference>
    <dbReference type="GeneID" id="119720350"/>
    <dbReference type="OMA" id="CNENARN"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000839">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000564">
        <property type="entry name" value="zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="57865" checksum="64CEFD1D8CB47305" modified="2023-02-22" version="1">MYINKKPFVCKTCGKAFSVKGSLQVHERVHTGEKLFVCETCGKAFRKQCHLKIHERIHSGEKPFVCETCGKAFSVKGSLSRHEKIHIGAKAFSAKCHLQGHEKVHTGEKPFVCETCGKAFRRKCHLQGHERVHTGEKPFVCETCGKAFLEKFNLKIHERRHTSEKPFVCGTCGKAFSVKGYLQRHKRVHSGEKTFVCEICSKAFFVKGDLEKHERIHTGEKPFVCKTCGKAFSDIGNLRRHTKLHTGVKPYVCETCGKAFSAKCHLQGHERVHTGEKPFVCETCGKAFSVKGNLQIHKRVHTGERPFVCEICGKACSGKGDLTRHERVHTGEKPFVCETCGKAFRKKYHLKIHERIHSGEKPFVCETCGKAFSVKNSLSGHEKIHSGVKPYVCETCGKAFSTKCHLQGHERVHTGEKPFVCETCGKAFRKNYHLKIHERIHSGEKPFVCETCGKAFSVKSSLSGHEKIHSGVKPYVCETCGKAFSAKCHLQGHERVHTGEKPFVCETCGKAFSNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z295</accession>
    <name>A0A913Z295_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045948.1">
        <property type="nucleotide sequence ID" value="XM_038190020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z295"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190020.1">
        <property type="protein sequence ID" value="XP_038045948.1"/>
        <property type="gene ID" value="LOC119720365"/>
    </dbReference>
    <dbReference type="GeneID" id="119720365"/>
    <dbReference type="OrthoDB" id="5957644at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="33"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="38585" checksum="091932E1980310A0" modified="2023-02-22" version="1">MNSTVPTSDNEEQFEGKWVCQIMTAEGVIGVLGNLLVCFVILRAKCLHNLTNYLLVNLAVADMLLCLHAFIYYLVTAEGCALISFVPASQGGRQIFCRLLASRFSVRALSYASAYNLCVVTLERYVAIVHPLQYERKLTATRMKTLITLIWMISFVLSLPILFTIYPSDDPEQACSEITYPHQMFPLILNIGSFILGYLVPVTSMSLAYYKMQVTLKRQAKALRLQQAREAAYDLVIARQRLVSVLTIVLGAFVILLTPGFVTYLLCLHPTANGPFSFCASKYYRYTREICNLAYYLNSVINPIIYEFKYKKFRKALKSAFCSCFKKHNRNRVDIAMVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z303</accession>
    <name>A0A913Z303_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045376.1">
        <property type="nucleotide sequence ID" value="XM_038189448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z303"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189448.1">
        <property type="protein sequence ID" value="XP_038045376.1"/>
        <property type="gene ID" value="LOC119719964"/>
    </dbReference>
    <dbReference type="GeneID" id="119719964"/>
    <dbReference type="OMA" id="ICIVSEW"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="99"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36543" checksum="DC9F76CC6E85F9DF" modified="2023-02-22" version="1">MTYSNVGRDLSFSRDLVVIDKELGRGAFGRVLLGRAFGIEEAGKETRVVVKTLTEGADRQARLELLAELELMKTVGSHPNVVKLLGYCAENDPVYVIVEYLAKGDLKNVLMEYRGKDPGTGYSNLPGLSKSLSRTLVKFARDVANGMAFISSQKCVHRDLAARNVLVGDDMVCKVSDFGLARDVMNTRIYQRESQGPLPVRWMALESILDDVYITESDVWSFGILLWEIVKLGARPYLLMNTEAIVSQLQQGYRMPKPQHCTKQLYDMMRGCWQESPKDRPNFQSLHQQLDDMLSEDKDYITIPKLDESIYEVTMIEDANEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5X0</accession>
    <name>A0A913Z5X0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046406.1">
        <property type="nucleotide sequence ID" value="XM_038190478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5X0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190478.1">
        <property type="protein sequence ID" value="XP_038046406.1"/>
        <property type="gene ID" value="LOC119720683"/>
    </dbReference>
    <dbReference type="GeneID" id="119720683"/>
    <dbReference type="OMA" id="HYQPYGS"/>
    <dbReference type="OrthoDB" id="10034090at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18943">
        <property type="entry name" value="bHLH_E-protein_E47-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000001">
        <property type="entry name" value="Putative transcription factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="510"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="636" mass="68147" checksum="9A29C2E746D29424" modified="2023-02-22" version="1">MNLSVEPTCNTIRSYIDRQSLNMLFLESLVNVEDCMSLSGMPTLTSDMSSGSSLSPHAKPGSPYYYSPHHRRRPLVPEHPTFTGPPKRRKGPPGGLTVYSPNSQEDYHHSSDPSSYPSPKPPGIYPNEYFMDAASGTHSPHSTDPWNSNGLAPSSASFHSTSILGNSASSYSQSQTTYPPHEPMGYGQSQSGGHVHSHSLSPDRDPLSLPPMSTFRPGTTTSSTHPHSPYSTSSPTNGTDTTLTVRGTTNVSGGGGNSQTGDTLGKALASIYSADHTNSSFPSNPSTPVGSPPPMSGPWPRSSTQASPGPYVESHLHSLQSRMEERLDDAINVLQRHAEGALQAMPNHPSGMVPPPAHTGAAAAINVGPSFAPPGQYIESHMSGSPSVERNAVAGPVSASEMSQTQPFNAGVQGDMMSQSMDTDHKPAPKPKKPKTSPSSDPKLKLNNSKDSHDKMAECDDPSTTQSTRKETVPAPKSKKQYDEFTSVSGDESGDDSSLTPEQKHMKEKERRHANNARERIRVRDINEAFKELGRMTCIHLKSDKAQTKLSILHQAVSVITSLEQQVRERNLNPKAACLKRREEEKVEERNMGGGGGGPPSSDSINSPPGMGSSWSPSYMSQSPGSACNLRQPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6M1</accession>
    <name>A0A913Z6M1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046465.1">
        <property type="nucleotide sequence ID" value="XM_038190537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6M1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190537.1">
        <property type="protein sequence ID" value="XP_038046465.1"/>
        <property type="gene ID" value="LOC119720721"/>
    </dbReference>
    <dbReference type="GeneID" id="119720721"/>
    <dbReference type="OMA" id="HVVCKRC"/>
    <dbReference type="OrthoDB" id="5974613at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="211" mass="23027" checksum="267892E63F661151" modified="2023-02-22" version="1">MSSTWVPKPPRNAAAAGSGAAQWPKAVGSRPTQPRSTTTESLGAYTYFSQGNPGSYPHRPSQMVTSPTQPQHRPSTPTAYKPINPPSQPQHRPSTLTMYQPVTPPSSPPRPTGPSPVQSTKRVVQPQREIKSPTAGISSSSRVSPSSSTRPTSPRCICHRDHSKIMCYVCGKTQVGRVRMQCPEHPNTIHLMDYDRCPVCKAVNLAEMRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8X2</accession>
    <name>A0A913Z8X2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IQ domain-containing protein E</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048238.1">
        <property type="nucleotide sequence ID" value="XM_038192310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8X2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192310.1">
        <property type="protein sequence ID" value="XP_038048238.1"/>
        <property type="gene ID" value="LOC119722244"/>
    </dbReference>
    <dbReference type="GeneID" id="119722244"/>
    <dbReference type="OMA" id="TLISKCQ"/>
    <dbReference type="OrthoDB" id="2136082at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052318">
        <property type="entry name" value="CellDiv_DevSignal_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22590:SF3">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22590">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="84089" checksum="98C854F6AD70AE37" modified="2023-02-22" version="1">MPTIQDIDPEESFYSDDSFSDNSDEELRVESRGSRATPLSVRPKSAPKRTPRKAGSTKPPSPYQQRPSSAKQRGKNATLSSSGPQKSSRELWLQSLRLGTGNLTGSGRSSNYTGKAGTANAGLNSCSDYLKETVLGMTSRKHQRGNTVDEPLNRNSKGVPSYKPKEDMYDDILELKKQNNILKAESERIKARNRRLEDEHLKKERTIEQLLDPTKGDVRMTLTSKQPDTAAKMNSLKQKVVKLEMVLKDRETELSNLKSDLKTTKIDEMRVGMEAFYQEVQRLRYLQSQGIRENGRSPSRPNTAEKDPNSTAKLKALNATILRLTESNQRLQSENKLLKQDLERALDEAMSDLGDTPRAKKRRDRKRDYEDMNRKELLTAVLDLEDQVAKLEGKTTSNSSRRSEMPEKIELSGTLADRLDQLDKRETELLGDKVKLEKDCNRLKDDKAKLRQRVDELEDEIQVLKKELSESASKDKDRRRSLQRRSSSDSLHSSRSQKRQHQKQREEEEWIRERDRRVEEFRKNRSARNIQKNWKAHQKRAVDEDEMDDAAVMIQSAVRGHMGRKEQMRQQDTKRRRSNRSVYSDDEDEDSEMDDAALTIQSAVRGHMSRKDYMKKTSDDSASEREERRSSRSRSGSRHSRYNGNISSRAVSEIEEDIVDSDDDSIVIGGSTANLRMSSNQSSRTTSARKDREPASRGRPPTGKSRLSPRKGSGDSEEETSSRKGRSNKAKKGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z977</accession>
    <name>A0A913Z977_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047435.1">
        <property type="nucleotide sequence ID" value="XM_038191507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z977"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191507.1">
        <property type="protein sequence ID" value="XP_038047435.1"/>
        <property type="gene ID" value="LOC119721425"/>
    </dbReference>
    <dbReference type="GeneID" id="119721425"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042607" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="676"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="819"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1183" mass="129590" checksum="E8D5BDA5A1FBD397" modified="2023-02-22" version="1">MKPVLKRHIFWLVIFMAFALSEMPVSALDLHLPGNNQPRCAGISRGKHFVLGFIDSYDDSHVASRELFILVVAFSNQQTTVTISSKHEIAGKPFQETFVIDAGEFIRTNVPVELVMENTERNQKVLEFSASSDVSVYGLMYQDYTTDGFLGIPTNNLGMQYVVMTSRPLVDQNSQFAVIGTEDSTLVQVILRGAVTFEGQSYSAGDVLRFTINNLEAVQIQGQSSEDLTGSIIQSDKPVAVFSGNECTNHAGSYCDMVTEQLVPVKSWGQRHIYTAARSDDDNIYRIVAYFSETNLTIPGFEHQSLEPGEFWEGRLSGSGLIRSSKPALMMQHLASINGITVDPSIIQVPAEEHFGFVFGFTTPPHSGGDSGGYFNFINIIVKNESRQTVYLNSLPINGSNVHESDVPHTNYASLTVQLPKGEGVYYVEQTDPFSSPLSVIVYGYEDAESYGYAAGLSLPSNKHVLSLTPYYLRELGGELFTMTVPCLQTNAISFQIAAKCKFATGFGDVIVSGERTDPYTVVCITPTFYKNGLTSVYVSLDDGGSFPYSGIVYVASEEDLPPLVQIQQVNSEYEDGIIDLTSDGPIMLSWDPRSLGEGVSHVTVMIQDTDYDSDGNPVLMDGVAVKSNVLNNGSLMIYPSELDSLIGDGLSLRATYLTPSAVRKRALPLVMVWAIRIYKVLKIVKRICNISKYHFKTTVPTEIPACPCNTGQADRDQNFQEANFANSFFHPGAENCYRSVNSLPTGAGQQCCYGTDGNILVGPPGGGTADRYSPGEHFWKHQWFDVLPWLCLCKLSNNCKEYHKYRPSDDCSDYDPPRPAGGTGDPHLTSLDGYKFTFNGAGEFLMASSAVHNLTFQARMERYRNTNASVYTAFVLQTNDSSKVQVQMSNMNETLILVDGEPLRLDSIPVKVHRLRGVRIRLNSDMTKVNIAFSAGIAVTVYIDTEVMSFIAQLDTKFQGQVQGLLGNLNGNANDDPQFPNGTILEPGSSLKELHDFGLEWLVAPEESIFTYISPFDYSTYHFPEFSPTFEIPDLNEVSQEIKDLCGDSIECVFDAVITGSLSFANETLVVTVTITEVQKGLVKIVSCGYPGDVENGLLSGSVYFVNATVDVACDDGFTLKGSSRLTCLEDGQWSSDLPVCAGMDNGEEGGLTPGIIAAIVVGAVIVVLAICGLIYIFVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9Y0</accession>
    <name>A0A913Z9Y0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="4 16">2.4.1.132</ecNumber>
            <ecNumber evidence="3 16">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 16">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79023"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19514"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:229641"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:79024"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13 16">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alpha-D-Man-(1-&gt;6)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79027"/>
            <dbReference type="Rhea" id="RHEA-COMP:19514"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:229641"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:79028"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4 16"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3 16"/>
    <dbReference type="RefSeq" id="XP_038048588.1">
        <property type="nucleotide sequence ID" value="XM_038192660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192660.1">
        <property type="protein sequence ID" value="XP_038048588.1"/>
        <property type="gene ID" value="LOC119722503"/>
    </dbReference>
    <dbReference type="GeneID" id="119722503"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000085">
        <property type="entry name" value="alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000097">
        <property type="entry name" value="alpha-1,3/1,6-mannosyltransferase ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="18">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="17">
        <location>
            <begin position="207"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="401" mass="45147" checksum="B720749B5317C4C3" modified="2023-02-22" version="1">MKVVFVHPDLGIGGAERLVVDAALALQARGHSVKLLTAHHDPSHCFKETSDGTLDVKAVGDWLPRSFCGRFYALCAYIRMIYVALYLVLFSGLQYDVVFCDQISACIPFLKMRRKPKVLFYCHFPDQLLTQRLTFLKRLYRAPIDWLEEKTTGMAHCVLVNSSFTAKTFAKTFPSLSHIQPDVLYPSLNFAAFDGPVQTPTDLLPPNVDTLFLSINRFERKKNLGLAIEALGKLLENLPAKERKGVHLVMAGGYDERVTENREHYLELRQLVDRLQLADHITFKRSFSDAEKLSLLSNCSCLLYTPSNEHFGIVPIEAMYMSRPVVAVNSGGPLETVVDGKTGFLREPDAESFAEAMREFVTKKDLTKIFGKAGRARVVSSFSFKAFGNKLDRLVRKLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA14</accession>
    <name>A0A913ZA14_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047841.1">
        <property type="nucleotide sequence ID" value="XM_038191913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA14"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191913.1">
        <property type="protein sequence ID" value="XP_038047841.1"/>
        <property type="gene ID" value="LOC119721953"/>
    </dbReference>
    <dbReference type="GeneID" id="119721953"/>
    <dbReference type="OMA" id="PALWHEH"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036977205" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="36459" checksum="BF58629A35034C6F" modified="2023-02-22" version="1">MYSFVLGAVFLAAVQVSASLIASPDPNSYRCPHGYQFYSGKCYKVVTVAKDHAAAQAHCESTGGTLASPNSQEEIDSIMDLVGQTTAVPDLLWLGYKDETYEGTFTDGSGKVLTHPTWSNGEPNNCCGGEHCLQLYRNSGLMNDLGCHREIGFVCSACSQDLSCRCPALWHEHDGDCYRFFGLPRSFEDGEANCQSYHNAHGQPAHLASVSCQAENDFITNFIAQSWPGQGLRRTWIGFNDIDHEGNFEWTDHLAEEYTNWKSGEPNDSNNNEDCTEINFEQPGIWNDLGCQTKQSSVCKMPVFDPYGACHKLADIITHLIGQCSAALPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDI1</accession>
    <name>A0A913ZDI1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049116.1">
        <property type="nucleotide sequence ID" value="XM_038193188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193188.1">
        <property type="protein sequence ID" value="XP_038049116.1"/>
        <property type="gene ID" value="LOC119722826"/>
    </dbReference>
    <dbReference type="GeneID" id="119722826"/>
    <dbReference type="OMA" id="GAQGKYE"/>
    <dbReference type="OrthoDB" id="10048500at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="58325" checksum="9A93518E144BA0E8" modified="2023-02-22" version="1">MLVTGNVSPRTRRRTDHTPRGLRSVTQIKRVTSTKVAPFRSPPRDVYFSIEKTIPHGDHEVRTRPNSRQNADTMQDYFPSVSTEQASRPNSKAQPRCESVPITNTDPANLDSTDVDATRSSTAPPNIDLSLKLSDLENLNMRADDVATVAIEKEQQKFHTERRLNISSAMGVRQHGSPRYASLSGTPTGRRKRREREHAYLCMKFRERPCVRTESFLNDDLYDRVNNMSRECCDVLGPKACHECDRLNRRSNSALRNEANFPSIHISAANFSTMTIVNRVRPELNSRQVLERLAQGDISRQSFSRQRTSSDEKRQEQDSEVDRPARRKKTSVSAFTVPDGLGFFTNFTDLTAQIFAKKRGERSGRPRHFNQGVGDSSNLPAITDVELVPKKEWERENPANYFGPPMLTRAEIERQKSHPRFYAGAGAKYELPEAPSFDEIAFQASGARHKRIRQLEARSDTPDSEISLFSVKSSHKDDEQSVAPSETETNTVSEDTDAKTTVQDLDNNLEVEPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZG93</accession>
    <name>A0A913ZG93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050023.1">
        <property type="nucleotide sequence ID" value="XM_038194095.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050025.1">
        <property type="nucleotide sequence ID" value="XM_038194097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZG93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194095.1">
        <property type="protein sequence ID" value="XP_038050023.1"/>
        <property type="gene ID" value="LOC119723440"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194097.1">
        <property type="protein sequence ID" value="XP_038050025.1"/>
        <property type="gene ID" value="LOC119723440"/>
    </dbReference>
    <dbReference type="GeneID" id="119723440"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000025">
        <property type="entry name" value="Calcium-binding protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="337" mass="39007" checksum="7AD21EBD9553068B" modified="2023-02-22" version="1">MPLFGKSAKTPQELVKIAKDALDIFDKCQEGKKAEKALEDVSKSLVGMKNILYGVGDQEPQSDLINQLGHAICHTGLLLLLVKYLRHLDFEAKKDVAQIYNNVLRRQIGNRMPAVDYICSYKEILFILCKGYENQQIALNCGIMLRDSIRFYELASIILKSEDFFNFFNYVEMSTFDIASDAFATFKELLTRHKVLCAEFLEGEYDRVFTEYQKLLNSENYVTKRQSLKLLGELLLDRHNFTIMTKYISNTDNLKLMMNMLRDSSRNIQFEAFHVFKVFVANPNKTPAILNILNKNKAKLVEFLTAFHTDRTEDEQFNDEKAYLIKQIKELQPSEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGB5</accession>
    <name>A0A913ZGB5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050049.1">
        <property type="nucleotide sequence ID" value="XM_038194121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050050.1">
        <property type="nucleotide sequence ID" value="XM_038194122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGB5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194121.1">
        <property type="protein sequence ID" value="XP_038050049.1"/>
        <property type="gene ID" value="LOC119723456"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194122.1">
        <property type="protein sequence ID" value="XP_038050050.1"/>
        <property type="gene ID" value="LOC119723456"/>
    </dbReference>
    <dbReference type="GeneID" id="119723456"/>
    <dbReference type="OMA" id="WMAICND"/>
    <dbReference type="OrthoDB" id="547291at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000032">
        <property type="entry name" value="Si:dkey-14d8.20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324092" description="SRCR domain-containing protein" evidence="12">
        <location>
            <begin position="31"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="152"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="261"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="372"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="481"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="593"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="778" mass="84706" checksum="1A8217650D9CA95E" modified="2023-02-22" version="1">MFMTFKHIMTWQERLLWFGLLVFSSVSSQAQSIDRFDEIRLSDGDLGPHEGRLEVYVNGSWAAVTSTGWGLNEANVVCRQLGFHASFPAAVGHRFGTGIETPVLDKVKCNGGESQLDECSNRGWLCRGTCSGDNYAGVRCINKAMPEPLYQLRLAGSASQFEGLVEVRYNDYWSPVCGIAFDFLQAITVCRQLGYGPPKHYRIFTEIDPESRPKLIHRASCHTWHRSLLDCGVNEGDGTVCTPSDPAAHVACNKPSDPYPLYLDSLSHRYEGAVRIYSDGQFGKICNTGWTLQDAQVVCRQLGYGSAVGHNVAPEDLAGPSGEPILLDAVQCNGSESLLAECSHKPFRDTACDDQQQALVECREPALEDLTLHIADGSAYRGRLEVAFNGEWLAICNDTWDMAAANVTCRQIGLGPALLATAEFEFKPQFVIWNEVSCEGTEDRLAQCRTSQSGQYSCASGKLAGVTCSPYGIPNKQADKLHLTAGILPHDGAVQLYRNGIWQAVCPSGWDGRDALVACRQLGYRGAVDNNAFTTEGPFYMDNVTCAGSELNLTSCGHDLLRQGARCKNDVGQAGVTCNPFTGIQSPADSTPLRLVGGKTSREGQVQVYFAGSWGAVCGGRTWDMNASHVACRQLGYERAEETGTGDVEKGTMFLLDGVECLGTELMLSACAHAPWGQVNCSPSQTATVVCKERPDQEVDAGISEWVYVGIVIAVIVIVLISVLATCVTWSMKKRQAERRIREGPDHHNVRHEHLEQRGAAAETANSSRPATTETKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGB9</accession>
    <name>A0A913ZGB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NXPE C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NXPE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050055.1">
        <property type="nucleotide sequence ID" value="XM_038194127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194127.1">
        <property type="protein sequence ID" value="XP_038050055.1"/>
        <property type="gene ID" value="LOC119723461"/>
    </dbReference>
    <dbReference type="GeneID" id="119723461"/>
    <dbReference type="OMA" id="VHPKEAC"/>
    <dbReference type="OrthoDB" id="2112051at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="3">
        <location>
            <begin position="341"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="576" mass="65879" checksum="B668B9BECA6AA0E1" modified="2023-02-22" version="1">MEQFRQFSWKGVTILAKMDEETEYLTSLPRRSRFVVIVLLSFCFISFVFLYASSSKPTVNSIDDLKKAWNMGQYNVHRLADQENKHKSPSDITHAQSSTYRFGPSSGLVVSKGATLRLVIEARDRAGKQTKRGGDMWYATLNSLKPKASTAGKVSDNDDGTYDVTFYAGWEGVARIDIILVHPKEACSFVEKKVWPTEDRVVWVGTFRVKDQSKEDHTETCVLRRNETNWAKKCEYWYPSEIGGTMLICGKPEDEERWTCDDLYALKSLDARIALAASELIEGKEYLFEGENVMQIVDEGPKHIQIEGATDQQVVPALLPPCQPGLQAPGNSEGYWLNDQWHSLRCQNFQWGVNDSKAQEASRCLRGKEVYFLGDTTARQWFEAFQESIGLKFFLRNDDAHYRFLRHHPSLNLSVLYQARPLLTTSSKVPFEEVQFEVDVLDSLKNPKCNYIIFLSLWSDTNWDRPSFTKRLNLTKEAIERLTVRCPEARVVVRSPHPVAHGTFETSAYADNILLFGIKDLMTETFRNTQASFLDVWDMSLAYPSPNKRDMPHEVTQQGVNLFMSYVCQSSTRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGK6</accession>
    <name>A0A913ZGK6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050927.1">
        <property type="nucleotide sequence ID" value="XM_038194999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194999.1">
        <property type="protein sequence ID" value="XP_038050927.1"/>
        <property type="gene ID" value="LOC119724090"/>
    </dbReference>
    <dbReference type="GeneID" id="119724090"/>
    <dbReference type="OMA" id="NASCESC"/>
    <dbReference type="OrthoDB" id="6265224at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="642" mass="72403" checksum="5884ADC0F299CCB7" modified="2023-02-22" version="1">MAEAAAKTVLDRISQGHLECPICCCRFKDPKMLDCLHSFCLNCLEEMMSKQKSETEKITCPVCRRETQVPDEGLQSLSSSFFLISLVDEIKTQEQLLGKETTNASCESCEEGQEAVSRCLDCKENICKKCQEAHQFLKYTKDHRIIPTEDLDKLRVLPTDVTKAVVPKCREHIEQPLCFHCETCDILICSMCAATEHRSAEHKFVGITNAIESFRESIRTILQKFEKSREQFASNEDSIKHARNRLQEKLARGRSAISSKAEAEIAKIRNKAELLTENLNEIGQERDSEYENSLVHNRDQMERADQIVTAVNDLMRQADDFELLELKPKVMHNLEFQKELKCKPARLDLAFIGVKCQDVVSDTDLGEILLEEKWQLKEEFGKEGSGDGEFQLANSVARFNNGDIVVTDTIQKRLSLFTSDGQHKKSIDKGAGRHQLQAPWGVVVNYDDLLFVTDINKVKVFDYKLQFVRQFTPSVNDAEGLSRSALTDIAMDTQRVAVADWGRKIISVHNLDGSMIATTTNDMVNYYIAITDKIQDRLIFTNYRKNRLLCVDFKGNEMFNVMTSLNGKPAKPTGVLCDDDGSIYVAVHADTLGKSVVQHYNSDGAFISTVARGLYNPLGMAFTPAGGVVVADKHSVKFFQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH09</accession>
    <name>A0A913ZH09_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051072.1">
        <property type="nucleotide sequence ID" value="XM_038195144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195144.1">
        <property type="protein sequence ID" value="XP_038051072.1"/>
        <property type="gene ID" value="LOC119724199"/>
    </dbReference>
    <dbReference type="GeneID" id="119724199"/>
    <dbReference type="OMA" id="QWRICTV"/>
    <dbReference type="OrthoDB" id="10058792at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="26934" checksum="5B46F6C62A32C83A" modified="2023-02-22" version="1">MKSAVKNVKLRECYKETQLWIPEPGTFSKRFPSTVSTYVAEEDTNTDSSVAMGMGLTATGVVWTLVSFLSTCLCCAGFVFPYWIAGAAQVNDPHVFHFGLFRRCNYPTSERQTVIGCGRYSSFEDIPTLSWRLGTILVGVGCAVSMLVAFTGILACCVKDLVTQKVGRVAGVIQIFAACLVGAGCALYPNGWDHPQVKMACGERSGSYQLGECSISWAYLVTIGGCGLLILSALLSCRAGRRKLEAYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIE0</accession>
    <name>A0A913ZIE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Apoptosis inhibitor 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051557.1">
        <property type="nucleotide sequence ID" value="XM_038195629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195629.1">
        <property type="protein sequence ID" value="XP_038051557.1"/>
        <property type="gene ID" value="LOC119724529"/>
    </dbReference>
    <dbReference type="GeneID" id="119724529"/>
    <dbReference type="OMA" id="RCIKFLA"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001577">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67524" checksum="A8218FBF4D10EDE1" modified="2023-02-22" version="1">MVTIEQLYKDYGVLADAGDKAGEHEAEYRSILSAVTAGTNEKKLAAQFIPRFFRFFSGLAETAINAQLDLCEDDDCMIRRSAIKELPNLCKESTDHLLRIADVLAQLLQSDDPHEVSIVNSALMSLYKIDMKGTLGGLFSQILSGDDLVRERAIKFLNTRLRLGGADNLPKEVEDFAIEKTKEVLADVTGEEFVTFMQLLSKMPAMQTLTGRQQMVDLVVEQADLESPFQPQDADIVDRLVQCVREALQFFSKNVQSTKFVVYMCDNVLPVLNDVVPPGSGETKTEGTEDKTPSDKTPSDKTPSDKTPSDKTPSDKTPSDKTPSDYDIKLELLRQLAEMSTFALDIGGDETLGRVFDKLVEYMPLPPAEPEGENVENGKATDEPKLQFSYVECLMYTFYQLGRKRPEFLAAEENSERLKDFRIRLQYFARGTQLYMKQLRLALQGKVGEEMKKEENRLKVVALRVTTNINTLIKDLFRNPPSYKSTVVLSWRPVQKHATSPEPAALGQKRSNITPITFPSDPSPPKKVSSGGQRKPHVARVMYQPPSGKYSSKAGTAPSDPEFGVGYMYGGAGGQRQTQWRGGRGQGRGQGRGQGRGRSRGGKWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ50</accession>
    <name>A0A913ZJ50_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051389.1">
        <property type="nucleotide sequence ID" value="XM_038195461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ50"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195461.1">
        <property type="protein sequence ID" value="XP_038051389.1"/>
        <property type="gene ID" value="LOC119724412"/>
    </dbReference>
    <dbReference type="GeneID" id="119724412"/>
    <dbReference type="OMA" id="IFRRCAR"/>
    <dbReference type="OrthoDB" id="10045204at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="50852" checksum="8C656F8555B3796A" modified="2023-02-22" version="1">MDDIQLNAAKIIAAQKKRNNRARSPESESNWDSSEPEDTLPNVSSEEEVSVVSSRSRGKDKSHIPQAPRQDSKSTRSQFQPHKPAKSNRLAVNGEQFSNKSSPVSSIRSGKVTKAGVNVFIDHGTGDSSDEDVSVASRKSAPRKEERPPYDFRKALDDAPRNEDRASDRPGKSRKGKIYDPMPPSGHSPRSDQTQLIVDAPDRRKATKNKWKVNQGFQEDTEHPATTTDNNNLGELSPRDATMTTMMSTTASDVRLTQMEKSMMGRVEDEVDVRRYDEPRMQGSHLLVQENTHRYIYHYQHGNTKYYDTRPVRNDVYMTGIADKSEKLVRRGVQEFFAALRIIVDFLLIVILELLRFLAYNVLGLLFVGLLTTFGDYFFKPVLAALFNSILQPLAVFLYNTGVALKTVFDPLIEIIRGLFIQVAMLLRALRLVEVNWRAGPRDLRGVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ92</accession>
    <name>A0A913ZJ92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serrate RNA effector molecule homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051863.1">
        <property type="nucleotide sequence ID" value="XM_038195935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195935.1">
        <property type="protein sequence ID" value="XP_038051863.1"/>
        <property type="gene ID" value="LOC119724743"/>
    </dbReference>
    <dbReference type="GeneID" id="119724743"/>
    <dbReference type="CTD" id="51593"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="6">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="5">
        <location>
            <begin position="734"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="891"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="111976" checksum="36A5EF60ADF98D24" modified="2023-02-22" version="1">MDSDDENDRRRRDKFRRERSDYSDRRDRDNRRRDDWNDRRRRDTRDLRDWNRRDYQDRGRRDRYSPPPRDLSPPSKRMRRDWDSGGGYNNYNMPYGGGGGGNQGYGGHQQGHGGWGGGGMHNMQQGPHHGNQQQRGGPDHDHGRGGPHGPHIMSFKQFLASQDDMIDDTEAVRKYNEYKVEFRRTQLSEFFLAHKEEEWFRSKYYPDEADRLKAEGLTSVRRRLLVFLELNEGDWMDKMKLQSDRNDEVSRILDAAVIKLEGGTPLDLKALDQQFLSPRRRMTSETLGSAHSPRKAEVKKEKEEIKVEVKEEKPASTVKEEVKKEAEDKKPDEAEIVSPKKEKVPEPEAEGDKEPKTNGEEKPQAGAEKRGKKRKRRHDSDYENDSGSSSSSGSISSGSESESEPEPAPPGIDDDVLPSDKLEEDKAAEKARKEAEEDDGELKEGDKDGEEGEEIPVPRPLHKTYSLFIRNVSPMITKGEIVSLCKRYPGFMRVALAEPQPDRNFQRHGWVTFDRSVNIKEICWNLSSIRLRECELSPVVNRDLANRIRSVSGITAHKKIIRSDLKLAARLVQQLDDQLRLFRPEEEARYMREEAEKKKRKEEEKKKREEEKKDEDDGEKKEEEEQRESSAEEKEPEWIIIPAKYKSNPVLENITDYLVEEVSAEEDALMGAKPEEEGEESSGEVLFLKDEELNKVLDRLLMYLRIVHSVDYYNTSQYHIEEEMPNRCGIMHTRGHNPPTRITHKDLTTWISNFETKLSSLLNAATIIPDEELVKMGKKDPESEVEKFVKANTQEIGKDKWLCPLSGKKFKGPEFVRKHIFNKHGDKVDDVRKEVTFFNNYLKDTNRPSLPEPLSQKPPGGGDRPGQGDMQGGGGGMGYQQQQQQQQFGGPAMGYGGQQQGGNFGSNRGFNQGPQFGHQQQQQPSFQRGGGYGGGFNRQRTRFTKRGDQLSTRKDPRHIVNYRDLDAPNDDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKB5</accession>
    <name>A0A913ZKB5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051764.1">
        <property type="nucleotide sequence ID" value="XM_038195836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKB5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195836.1">
        <property type="protein sequence ID" value="XP_038051764.1"/>
        <property type="gene ID" value="LOC119724676"/>
    </dbReference>
    <dbReference type="GeneID" id="119724676"/>
    <dbReference type="CTD" id="9776"/>
    <dbReference type="OMA" id="AIVQSRC"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51619" checksum="0415B74D387694A6" modified="2023-02-22" version="1">MMAKGSVEEPSPLRISPVSASSSNLNDRELRDLNKFIKFMAFKSVQVIVQSRSGEKIDSASKAKSDGTDWFNLAIYDNPTTKSNVKKLLAQELPRVGSPLNVEVSLETSEGDRMVLECWSLVLSENIDPNAKIHYAVYNRLGLLLKSLICISRVTPAYRIARHQLGADYRVMSRMYYGEMKLSLLGENFHSLNVGSVATPIGSVVLSVAYRTKLTLSVHQLQSSSVSPVSVRDDYYSSSSPKHKSPAAMNAPGHSPGRLDDSSTMDGSSDLCATSFSTSPPEPCILQTEFTTLPPGRSKVAEEKPRGGSPGLGSDLLSGKLGAFASPKHQADPSDILTGDIPFSSLLLEDTPLDNSSKDKSSSSEQTLSDQPDGQASSSSQHSKESTQSQHSVAEDFVMVEFNPAFAKPERNSDVVSFYRQFQMAPPLVMFDNQPSLEETLEILPTQIAKFEESQVEFDSFVQSLQHDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKI4</accession>
    <name>A0A913ZKI4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052322.1">
        <property type="nucleotide sequence ID" value="XM_038196394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKI4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196394.1">
        <property type="protein sequence ID" value="XP_038052322.1"/>
        <property type="gene ID" value="LOC119725028"/>
    </dbReference>
    <dbReference type="GeneID" id="119725028"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="220" mass="25105" checksum="E884EB27F2DD51D9" modified="2023-02-22" version="1">MDDLVNLNVGGCVYTTSRSTLTRYPRSMLAAMFSGELDPSVRDANGAYTIDGDGPIFRHVLNFLRRGKLNLPEDFKEWDLLTSEADFYQVGDLTDAVMAEKMRRVTPEDSSKSPKFEFVEIQIRNTIMDMMYIGSIETLGNLPVILAFLNTDAYYEGDVLDVVKQQGMIQHCSTSYTYYSEPVGDKRMLVFREIVEHGFELKAVLCDSDRNKEWTFARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM59</accession>
    <name>A0A913ZM59_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052429.1">
        <property type="nucleotide sequence ID" value="XM_038196501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM59"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196501.1">
        <property type="protein sequence ID" value="XP_038052429.1"/>
        <property type="gene ID" value="LOC119725139"/>
    </dbReference>
    <dbReference type="GeneID" id="119725139"/>
    <dbReference type="OMA" id="INCCITS"/>
    <dbReference type="OrthoDB" id="6075765at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="269"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="646" mass="72689" checksum="00DE037AB7E0DDF6" modified="2023-02-22" version="1">DNQLRMAEAAEATAKTMLGEISQGHLECPICFCRYKDPKILDCLHTFCLNCLDGMLSKQQPSIGKITCPVCRKETPVPDAGLPGLLDCFFLSSLVDEINQQERSLETQQQATTSPTCDECVEGLEAVSRCLDCVENLCQQCKTAHERSKRTQKHRVTPVEHPEQKEVPSADLSQTHSPKCQKHADQKMQFYCETCKMLMCGICATIDHRSADHQLSEIADAVRSYFEEVKYVLQKFQKSKEEFKANEESVEHARHRLKVMVTRACSEIQAKEEEEIAKIKNKSRLLRDKVIKIGKKRDEEFEKVHTNNKKKMERAEEIEAAVTDLMKQADDFELLNLKPKVMHNLEFQKDLQFDRVKHGESFIGVKCQDVVLDKDLGEILHKEKWKLKTEFGKQGDGDGEFNWARSVCCFSNGDIAVDDSNKNQVSVFTSTGQHKTTFDLNALYGISVTSDLLLANCEDHVKVFDINCQLHSKFNLSKPDAGDEPYIHTSDATVDNEHLAVVFNGQRMVTSLYNLDGSLIRDIASASICQEDIAISSKGRLIFTQYDSSILQCVEMTGKEVFAVRTSLEDKEATPAGVCCDDAGDIYVTFHCGPHTGSSEVHHYDSQGVYVDCVANKLLWPFGITFSPSGELVVADQNSVKIFHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN20</accession>
    <name>A0A913ZN20_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052446.1">
        <property type="nucleotide sequence ID" value="XM_038196518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196518.1">
        <property type="protein sequence ID" value="XP_038052446.1"/>
        <property type="gene ID" value="LOC119725157"/>
    </dbReference>
    <dbReference type="GeneID" id="119725157"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="654" mass="73371" checksum="ABFEC94AE7FA6E6F" modified="2023-02-22" version="1">MAEAAAITVLDKISQGHLECPICCCRFKDPKILDCLHSFCLKCLEEMLSKQKTEAEKITCPVCRRETKVPDGGLQSLTSSSFLSSLLDDVKQQEEVIGEASIPTTTCDCKEDREATWRCLDCSDNLCKKCWKAHGRRKSTKNHQIISFEDWHKSNIPGPEADHVKPITRMCTNHTDQALCFYCDTCHTVICPMCAAMDHRSAEHSYKKIDDSVRSFRRDVDDALLQFEKCKQRIKSTNNSIELARDILKDKLAQARIDISANAEIVVAKIRNKAKLLTEKVDEIGQERDRGFEKALTNNCDHLKRADQIATAVNDLKRKADGFELLELKPKVMRNLEFQKELNCEPAKLDMAFIGVKCQDVVSDTDLGEILLKEKWPLKEEFGKKGNRYGEFLFARGVACFSNGDIAVTDTELKRLSIFTSNGRFKLSATRRSHQLDAPLGVAVNTDDLLFVTDKKKVKVFDNNLCLVREFTPSQDGASELSAIAVDKASDRLAVADSGRKVISVHLLDGSLVTTIPNENVNRGLAMNNKDRLYIPNYDKKTLSCVDLKGNEVFNIKTFIDGSPASPVGVLFDDHGYINVTLHHGSRGSGKVQQYNPNGFSVRTVAEQLYNPLQMAYTPTGDLIVADRHSIKIFQRMWFTYLQGHGPAGNYQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQC5</accession>
    <name>A0A913ZQC5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053584.1">
        <property type="nucleotide sequence ID" value="XM_038197656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197656.1">
        <property type="protein sequence ID" value="XP_038053584.1"/>
        <property type="gene ID" value="LOC119726038"/>
    </dbReference>
    <dbReference type="GeneID" id="119726038"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="180"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="36464" checksum="15FE310A34F8307D" modified="2023-02-22" version="1">MPRKTVQQLDAYIKATAFVCDHSNAKLISRKTKVKPRRKQAFLSVLHYRKTSSDDCCAKRRPWNRWIRRKSKQTHESQSNSKDVKQKLQVFVRTPIPLKTKTLYFELRPETSVSSLKEVIQKKIGVETRHQRLYIRENVQLCDLLTLEENGVDTKEIISLRLSTDEQDNDNVPKDKASVDDEYLKDLSSKIESSWKELAKHLRYEESEIANIQTTNEGSTEGSRHMLLTWWEKTTDREEAARKLRRALEAIGLTDLAQNVPVVSELRDEAAEPEPERRHDAGVDEESKQNGAASTEEGKLKKEQVGDQDKPRLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQH5</accession>
    <name>A0A913ZQH5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038053321.1">
        <property type="nucleotide sequence ID" value="XM_038197393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197393.1">
        <property type="protein sequence ID" value="XP_038053321.1"/>
        <property type="gene ID" value="LOC119725811"/>
    </dbReference>
    <dbReference type="GeneID" id="119725811"/>
    <dbReference type="OMA" id="TFFQMYW"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="301"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="357" mass="39173" checksum="43E6712B13B540F4" modified="2023-02-22" version="1">MDLPKPVRLKDFEPFARRSLPATVYEYYRSGAYPEQTLRDNEHAFQRYRLRPGPLRDVSIRDFRTTLLGHEIAFPVAIAPTALHRLAHSDGELATVRAATSMGTGMVLSTYTSTPMEDVAAAASPNSLLWAQLTAYTDEEAVRRMIRKAEQNGFKAIVVSLDAKMSKRKAGADLIPPHVKFANFEGARSQSFTTVERNANPKLTWDEIDWLSNLTTLPIVLKGVMSGLTARKAMKHRVAGLWVSNHGGRSLDGSLATIDVLSEVVEAARGSNMEVYLDGGVRTGNDVLKALAMGARAVFIGRPVLWGLAYNGQEGVKKVLEIIRDEFSHALGLAECASPSDISQSLVVRDPFHTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQH6</accession>
    <name>A0A913ZQH6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053634.1">
        <property type="nucleotide sequence ID" value="XM_038197706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197706.1">
        <property type="protein sequence ID" value="XP_038053634.1"/>
        <property type="gene ID" value="LOC119726093"/>
    </dbReference>
    <dbReference type="GeneID" id="119726093"/>
    <dbReference type="OMA" id="HRTIYLD"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="636" mass="72186" checksum="295683A5B020DCEA" modified="2023-02-22" version="1">MAEAAAKSVLGTISRGHLECPICCCRFTDPKLLDCLHSCCLNCLDKLISRQQPKADEITCPVCRRGTAVPDTGLQGLPNCFFLSSLVDEFNKQERLLGDAPPDTLTCEECDEGLEAVTRCLDCDGNICQKCLYTHRKKKSTKKHRTIYLDRIRSQIPPIEFRMKNYPQCNKHPKQELCFYCETCKTFACAKCAALDHRTAEHEYTEIGAAIRSYRQDIGKIMLRFEKSREEFKVTNDSLTHVRNRLRIKVARACKDIATKEEEEIAKIKNKSRRLRDKVTTIGAEREKKFEEVQKSNRDKMERAEEIVATVNDLMRQADDFELLDLKPKVMHNLEFQEKLELVHAQHDLSFIGVKCQDVVADIELGDVLQEEKWQLKEEFGKFGSEDGEFQCAAGVACLSNGDIAVTDTNKLKLMIFNFTGEYRTSVGPEKLNDPWRLAATSDDLLLVTDERYVKVFDSSLDFIRQFVPSQNEEDDDSMSWLTDIALDKKNRIAVTDTRRKLISVHNLDGSLITNFQNDMIDYYLAIGIQERLFFTNYHGSKLICTTFTGDEVFNVKTSLDWEPVKPSGVCCDDAGDIYVSVREDGGGGEVHHYSPEGVFIGRVARGLHSPCSLTFSQCGDLVVADEVSVKIFQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS13</accession>
    <name>A0A913ZS13_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="13">PARP</shortName>
            <ecNumber evidence="13">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038054427.1">
        <property type="nucleotide sequence ID" value="XM_038198499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS13"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198499.1">
        <property type="protein sequence ID" value="XP_038054427.1"/>
        <property type="gene ID" value="LOC119726699"/>
    </dbReference>
    <dbReference type="GeneID" id="119726699"/>
    <dbReference type="OMA" id="HHITTDN"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08002">
        <property type="entry name" value="WGR_PARP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000009">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WGR" evidence="17">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="16">
        <location>
            <begin position="185"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="15">
        <location>
            <begin position="318"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="536" mass="59959" checksum="2CCC95417FD5ADB7" modified="2023-02-22" version="1">MPPKRKAAAAKAGGKKKKVEDPPATDSKSDIKKKVEALKTAEKGKKKTYVVDSYYSGSGAVYEDFDCMLNQTNISQNNNKYYVIQLIQSGKNYTVWSRWGRVGEPGANQMTSFSDVSQAIKSFEKKFQDKTRNKWAERANFAPVAGKYTLIEVEQSEDVKEDLKKLSELEAGGSKTTTKSSEYAPSKLDTPTQKLLDLIFDNNMFQEQMANFELDVKKMPLGKLSKAQLAKGFDALEDIETAINNKAGTKKLQELSSRFYTLIPHSFGRKLPPTISDAETLQNKKDMLLVLSDIVIAQDIKREQDETMSQSQAAVAPNPLDVNYELLKCKLEHLAPKSKEHKVISTYVDQTKGGWRQAKLLNVWKVAREGEDKRFAAHDSIENRRLLWHGTNVAVVAAILKTGLRIMPHSGGRVGCGIYFASEHAKSAAYVRSTNNGTGIMFLNEVVLGKEHHITQGDGSLKKAPSGYNCIIAKGRQEPDPKKDTNLVLDGKKVAVPQGKPVNQSKYNNSHFSQSEYLVYSESQNRIRYMLEFNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUN1</accession>
    <name>A0A913ZUN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055179.1">
        <property type="nucleotide sequence ID" value="XM_038199251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199251.1">
        <property type="protein sequence ID" value="XP_038055179.1"/>
        <property type="gene ID" value="LOC119727383"/>
    </dbReference>
    <dbReference type="GeneID" id="119727383"/>
    <dbReference type="OMA" id="RESKQND"/>
    <dbReference type="OrthoDB" id="10046160at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF17">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="349" mass="39982" checksum="B80EA3BA43ADE381" modified="2023-02-22" version="1">MLWAGTQAKYAFSVQRDGPCVPRQFTVFYRVLDLWIWCLEEYKDTETKARVQGVASQMQKFEFFFGLSLVAVVLANADSLSTTLQKRELSACESQRIASMTVNALRSIRSDDSFKMFWAKVLRESKQNDVGAPVLPRRRSTPKKLEECYGGVAAPEYPSTPHAYFRQIYYQALDLAVTSITDRFEQPDFKIYSHCEQLLLLAMSGADYQTELTTVVQFFNEDFTEEMLKAHLQLLKGSVSSCQMISELVKECQQLHPGQRDLMSEVIKLIKLLPTAPATNATSERSFSTLRRIKTYLRSTMKQTRLNHLMIADVYNEKMDAIGLQKVANEFVQGHHNRMARMALFALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUS9</accession>
    <name>A0A913ZUS9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 43 member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055312.1">
        <property type="nucleotide sequence ID" value="XM_038199384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199384.1">
        <property type="protein sequence ID" value="XP_038055312.1"/>
        <property type="gene ID" value="LOC119727493"/>
    </dbReference>
    <dbReference type="GeneID" id="119727493"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41328" checksum="37A7857AADECE912" modified="2023-02-22" version="1">MIGLALYRVLTLGLGAFENLLFSGVFFGWASLVYVVKQEGYFSHLCPPTNTSTNSTENVGITIPPAGLQISPSDPTQASTTLASVGPGGGFPTCPEQDAELQLMFTIATFCYEFLLFPMGIVLDKFGTLTMRLLSSCLIIAGLLLIAFSSRETAFLLYPATCFLAIGGVELMFTNMQISSLFGRRKATVMTFLSGCLDSSAFVFIIVKLLYESLGVPLQTSFFVLAGICLTMCLNTLLLPKTSHIPYPLPPGYRQAKPDTGRAGAKSDKGVENKVPMEDLDDKERNGQAGKEMHSSEATSDSEHDVVLPTDEDPPSSQSLTEAAKSDRYPSLCSCFLSLPSLCLLIWFSLLQLTMFFFLGTIKPGLERLTDNDQNVGRSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUV7</accession>
    <name>A0A913ZUV7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055045.1">
        <property type="nucleotide sequence ID" value="XM_038199117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199117.1">
        <property type="protein sequence ID" value="XP_038055045.1"/>
        <property type="gene ID" value="LOC119727258"/>
    </dbReference>
    <dbReference type="GeneID" id="119727258"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="8">
        <location>
            <begin position="652"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="785"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126692" checksum="16728065D09938CE" modified="2023-02-22" version="1">MAHTFPEIPVSALDLQSPNMNQPKCLGRSRGKRFVIGFTDSVYEYSFNTRLYIMVVAFSNQQTSVTISSKFQLDGRRFQESFVIEAGGFRRTNVPVELNMNGSERSWKGIEIKASSEVSAYGLIYHDYSSDGFLGIPTNNLGTQYVVMTLHPISRGHTQFAVIATGDSTSVQVTLRGSVTFEGQTYNADDVLRFVLNELEAVQIQGHDLEDLTGSTIYSDKPVAVFSGNECTTHAGSACDTVTEQLVPVKSWEQKHIYTAARSDDDNIYRIVAYFSETNLTIPGFEHQSLEPGEFWEGRLLGSGLVTSSKPALMMQHLASINGITVDPSIIQVPAEEHFGYAFGFTTPPQSGEDADGYFNYINVIVKNDSMETVFLNGSPIKGSTVHESDVPHTSYISLTVQLPKGEGVYYVEQTDSYSSPLSVIVYGYERAESYGYAAGLSLFSNERLLSLTPYYLRELGGEPLTITVPCLKTKVPVTEYAKCKFSTGLVDVLVSADRTDPYTVVCITPTFYMNGLTSVYVSLGDGKSFPYFIYIASEEDLPPLVQIQQENSSFGDGIIDLTSDDPIMLSWDPTILGEDVSHVTVMMQETDYASNDPVLMEAVSVKNSVLNSGSLTIHPIDLQSLYEHGLSFSTFYLTPSPEGNAALRLRLYSPAVITVTSMTCGVSKYPLRSTVPTGLPPCPCIKEQAEVDFNFQKDDDVCYRSVHSMQTGTGQQCCYGKDGNILVGPPGGGTADRYSPGEHFWKHQWYDVFPWICLCKLSDNCTEYYKYRPSDDCSKYEPPRPAGGIGDPHLTSLDGYKFTFNGAGEFLMASSEEHNLTFQARMERYRNTNASVYTAFVLQVNDSSKVQVQLSNMNETLILVDGEPWRLDPRPVKVHYLRGVQIRFNSDLTKIKIAFNAGIAVTVYIDAEVMSFIAQLDTNFQGQVKGLLGNLNGNPDDDLQFPNGTILESASSLKELHKFGLEWLVAQEDSKFTYISPFDYSTYHFPEFFPTFKVPNLNEVSQETKDLCGDSIECVFDAVITGSLSFANETLVVESTITEVQKGLVKIVSCGYPGDVENGLLYGSVYLVNATVDVACEDGFILKGSSRLTCLEAGQWSSDLPVCDGMEEREEERLAAGITAAIVVVGLIAVLAIGGLIYLVMKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVE3</accession>
    <name>A0A913ZVE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055648.1">
        <property type="nucleotide sequence ID" value="XM_038199720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199720.1">
        <property type="protein sequence ID" value="XP_038055648.1"/>
        <property type="gene ID" value="LOC119727704"/>
    </dbReference>
    <dbReference type="GeneID" id="119727704"/>
    <dbReference type="OMA" id="SFRECII"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="36778" checksum="49F1778A12E87A1D" modified="2023-02-22" version="1">METTTNEQMTATSNSTAEDVIVSTPFAILVKTLMVIAIVPNLLLNPLMLVTLRRVTSIQPTTKIFMASLTLSDLCSSFWSILILTSLFADTWLLGNFLCAVNNVMLFLFTGLSVSTLLLLTVDRYIAISHPLRYPSIMTVFKSKIIVCSAWATIIVSSILINGINPFYNIQVIGHNKRLCTSETYDWRVYLFLALVLLQLLTIFILYAHIALIARNQARRIAAENQAGNGQGGQRINTRSTTTIIIITGTLIITWIPTLIRLPIASQNQWEPYDSYLSFKFTQALLMSNGWMNVIIYYLRNKDLRQALCGLLTDWRQRLSQRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX37</accession>
    <name>A0A913ZX37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056084.1">
        <property type="nucleotide sequence ID" value="XM_038200156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200156.1">
        <property type="protein sequence ID" value="XP_038056084.1"/>
        <property type="gene ID" value="LOC119728082"/>
    </dbReference>
    <dbReference type="GeneID" id="119728082"/>
    <dbReference type="OMA" id="FANGSQW"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="620" mass="69254" checksum="6035F84802C9C9CA" modified="2023-02-22" version="1">MGCGASKTTAHESTSTSPKDAQQTKDRRQEQTQRREQEEQQQHPQQLQQKQPSPPHQHLQDSGPAKHSELKYLPKPTPPATKKKEYIPDSNVFADIDDHALQAPKSAASSVENLVNYLTKVCSTNLERIRVLFRWITNNIEYDVQSLRSGNIQGGNCTPDAVLQRGCGMCEGYAELFQDMCRRAGITCEKISGYAKGARYSAGDLFEGKDTDHAWNAVYVDNAWRLLDCTWATGFVNPAQPFQFKFKEHYFLTDPEEFIYTHFPYNKSQNMDKWQLLDTPWTLKQYEEAPFLKGRFFDLGISPSSLSHCRSLIEFDDSVKFGFSSDRQISVTHDLTDKASGQTFSQYSYLYVHQDDFKAVTLVVNPPSVGDYKLTLFAKERTAGDKEKEWIGDFLLRCTSVSCPKNPYPTGSQWGLNAKATALGLAFKGTNPSVAPDDTGLAKVEFKIDKNRPVETNCVLSKADGVGSGNSVLRTNTNDGFTYLVVVPSEGLFNCTLFAKPAGSEGSRQYMGDFLVESKSTPSTPRTFPHVYDLFGDGCELLEPMQGRLPANTELRFKLRVPDAGDVAVFANGSQWHHLENPSGDDLWQGNVATEVEGDLTVYKKNKKGTFSGLLKYTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXE5</accession>
    <name>A0A913ZXE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055970.1">
        <property type="nucleotide sequence ID" value="XM_038200042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200042.1">
        <property type="protein sequence ID" value="XP_038055970.1"/>
        <property type="gene ID" value="LOC119727960"/>
    </dbReference>
    <dbReference type="GeneID" id="119727960"/>
    <dbReference type="OMA" id="YGMVENQ"/>
    <dbReference type="OrthoDB" id="6107927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036975288" description="MAM domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="556" mass="60170" checksum="6786102151B66D5E" modified="2023-02-22" version="1">MELGDYQFLSTVIVFLYLLNGVTSNRELLSCSFETSCGMDHTTNSQFYWRRVSGATPNAYTGPSNDHTFGNGNGQYIYAPSSEKYYEFGRRSTLYTPLYRLTSGRGRIEFYYHMYDGLGTDDMGSLDVYVCGDSSPVWTRRRNQGNEWRSSGQVDFTCQRDFRVYIIASRGKYQSDIAIDDLIITDVFDDPTTPTVTTEPPTTKPTTPSTTTQQTTPSTTTAPTTTAPSTTTQRTTPQPPPTNPPTNPPTMPPTMPSTAAPTVPYKIMPTTRAKTIPLTTKAILTGAWTKSPQASTVTSASKDTAVSSTVTMTTASSLETEVDISVVPDNPSTVGISVDSNLQSGSSSPSFVGPIVVVCIALLLIGLTLCLAFKRKKSTRKPASKAAKEVTRVDNPSYCGEVDSLPTANNKKRANYSYQELLQQQSYSSIDETGRESDVEYHTLESSDTAGAGGDCSYQEIGEKNAPRRRGESALYTAIPDQGGVTNEYSYTYANRDGNGGSSSAAGRSGIAGRAPSEGNEQEYAAIRDPNSTGNEQGAAGSYGMVENQLYIPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZE7</accession>
    <name>A0A913ZZE7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056947.1">
        <property type="nucleotide sequence ID" value="XM_038201019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZE7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201019.1">
        <property type="protein sequence ID" value="XP_038056947.1"/>
        <property type="gene ID" value="LOC119728691"/>
    </dbReference>
    <dbReference type="GeneID" id="119728691"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15880">
        <property type="entry name" value="SNARE_syntaxin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000042">
        <property type="entry name" value="Syntaxin 11b, tandem duplicate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000005">
        <property type="entry name" value="Syntaxin 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="293" mass="33706" checksum="5386D5E3E41DA439" modified="2023-02-22" version="1">MRDRLGSFKRGDDDDVGPDDVSVNVDSEKYMDEFFDQVEEIRNNIDKIADNVEEVKKKHSDILSAPQPDEKVKEELEQLMADIKKTANRVRGKLKVMEQSIEQEESSKMNAADVRIRKTQHSTLSRKFVEVMTDYNNTQTDYRERCKGRIQRQLEITTGKSTTDEELEDMLESGNPAIFTSGIIMDTQQAKQTLRDIEARHNDIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEQSVDYVETAKMDTKKAVKYQSKARRKKIYILICCGILIAIVVILVASIVPNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2D1</accession>
    <name>A0A914A2D1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038057521.1">
        <property type="nucleotide sequence ID" value="XM_038201593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2D1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201593.1">
        <property type="protein sequence ID" value="XP_038057521.1"/>
        <property type="gene ID" value="LOC119729087"/>
    </dbReference>
    <dbReference type="GeneID" id="119729087"/>
    <dbReference type="OMA" id="NYIAPVK"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05034">
        <property type="entry name" value="PTKc_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="251"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="57801" checksum="73C19A029FCF46EE" modified="2023-02-22" version="1">MGCINSKEDGTSYRADTRNDSNDMGSPGMKITTPSPTIATGGVTDFRGNSQMFIPTPAQPKPSKPVLKYVAIYDYEARTGDDLSFLKGETLDITNNNDGDWWLARSTKTLQEGYVPSNYIAPVKSISAEEWYFGRIGRKEAEKKLVMPGVERGMFIVRDGEATPGTFSLSVRDYDPVKGDHVKHYKIRKLDNEAGFYIAMRSPFPVLAELVKHYQQVADGLCIKLTFPCPKENPNTVSLGRDAWEIPRTSLTLESKLGAGQFGEVWKGTWNGKTPVAIKTLKKGTMTPTAFLAEANIMKKLRHPKLCQLYAVCSDKEPIYIVAELMCNGSLLDFLKDGEGRNLKLPELVDMGAQIASGMAFLESMNYVHRDLAARNVLVGEGNIVKVADFGLARMIEDTEYTARQGAKFPIKWTAPEAAMYGRFTIKSDVWSFGVLLTELVTHGRIPYPGMMNMEVLDQVEHGYRMPKMANCPDTLYELMQKCWDKDPAARHTFEFLHSYLDDYFVATEPNYKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2Q2</accession>
    <name>A0A914A2Q2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058123.1">
        <property type="nucleotide sequence ID" value="XM_038202195.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202195.1">
        <property type="protein sequence ID" value="XP_038058123.1"/>
        <property type="gene ID" value="LOC119729578"/>
    </dbReference>
    <dbReference type="GeneID" id="119729578"/>
    <dbReference type="OMA" id="NEISASW"/>
    <dbReference type="OrthoDB" id="10042078at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1954"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="1632"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1865"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1912"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1572"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2009"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2111"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2014"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2025"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2143"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1900"/>
            <end position="1909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2153" mass="237647" checksum="56601CD5C4F28CDA" modified="2023-02-22" version="1">MAFSGPIEIDDTPPTYGLVVELSGVYSFNFSDPVNQPEWECASEEECLSLDGECLESLTQLQILWQPFTDEDTMITKYEVALGTSPGGSQIRPFYEVSKDQTSELITNIDLSSVRRVYATVRGYNEAGLTSTAVSNGIYVSRFSAGLQPLRPFQVKDGVTDVDLEDSDFQTSLNEISASWDFSGDPCPMKKYEWAIYRIDGQEIQPFINILERTSDTNTDIQMTDSETYYNLVRATNALGLAVTVRSDGITVKRDPLIPGQVYDGLLVGYDLTYQKETDRISASWKGFGQGTPVKETIHHTGNAEVTKDHITEQTVDYYEAAVGTDRRYPKTRDNVVPFTYVGQNTTVTFTNLNRMERDSTYYVTVRGYSASLATAEVTSTGINVGIDSTVLGSEVEVPKYVNSVSEVQLMWAKFQSTFPILLYYVGLGKPSTSSIPPEDMDCLDMLLRTTQALATFHERSMHFVGKDTFVEVKGLNLTQEGSYYVTVVGMNEGGQCNSSTSYFSVDITPPIEGRLRVGPFYDMPVAYTDSTESVSVVWEDYRDDESGIKSYNLRLVQAASCNEDEDNLTAVANQDWLVLGPDIQDFRFVDLNLVTNQPYFVQLSVVNHAGDSILSQVGPVFVDSSEPTAGLVVDGMDFKMDMTDSGDRSQVTGIILHLPNPEGPPCPLRDIPFTDPQWSAMDFKGLWNMNRKKWDLEYQSQQVHASDESVMLIMERDTRGPRMLSGAYVTNAQIVGSSEYEFDLKAAPPDLHSVTSILFWDGPDGAIGEYDFGGRENWQEGICQCCYDQPFNQSMCPQCDCQDFLGILDSSEDNSTFASTTNRSLEATPTNEVTISKMAEVTSASLTTMGSLPWTIQKMDEDGDSVSDDESGRWISQRACGIQLYPNGSTSQAVLWCRYFEDAWRMTSEVIDLDFDPSIEEHHFSVHIKVMPFDANEDEWSFEVYVDGKLLSSLTGIPVLSSSTKLILHVFNQDSYIAELPDPFNPPAVAATLKNLRMSPDQSNLCRYGASFRAGTSPVSRYFAGVGSVAGATDIVPFEEIARPCVPCIHPCDRYQCDPSCSLDAVPITFTLTNLTLPRLELSNTTLDNDANATTPPANQDEGSLPFFLTVRCFLGNGKSVSASSNGFVIDDTPPKLDLFFYVDVNLEESVPTSFQSSDSTIRVLWSFIDTESMVKEHHWAIGTSKGATDLQDFVNVGLNQTATNSNLTGLLHHNTTYFVTLKAINGAGLETIIECDGVTVLLEEPTADDVNTTSMFSKKFEEDVYPTDVKKSEDPTKTGTSWSKPQDESINRYEYCVSGSESLLDDVVPCMAVGGNSSGSVTIEDGMIIVRAGDREERFNITDFKAPKDSSQGDMIEKAAKFNMEPGKCLYTWMKMCNPAMLCVTVSAGTTTVLGDSDMMMTSANGTDLVLTSPTSQRRRKRAIDDNHFDFTVATKGGLHQGGSLILGLLDVNRTNQEFTSDAALDYKPYITNPLYTIPYTSRLLRHRIRFVYEPTFYITSLGQTELQGPLMINMSLSTPGNWTVEKPRLIYWDKDHSEWQDAAKTCSDVDQITYLDDGNKVNVQVCSTQDPALSSSEPGRKRRALQEESVPSNTTYFSHETHFAFAVVLDAIPNNPPVITNLVENMFMNEDEGTLSYTFQATDLEDDILVFELGSHSDKQGTAVITETGDFSYTPCTDCYGTFTLQITVREVQTFHEIEPLSTTVNHTIEVRPVNDNPVLYSAHNGQVVGNGRIASLTVEQNTGSNVAYKHLRAVLGAYDADTNDELTIVTRPPTYGTLALTSQVKTVPSRQNCSEPSVDSEEPVIPCGIELPHSEEDLSWTTSTFTYAPNPNYHGRDSFLVLAEDLSGAVSQLLEVQIAVLVNPCIHEGVCRGPVEDPDCTSPARSSGFESYSCHCQPGWVGDICEIDYDECQSTPCAYPYVCYDRLNGFECACPLSDPLCDDLDWSVKVMIGVVSCLVGLFIIAVVVSCLYKKKHSKKLKIHPIILGPDDDQVVPSISGNPRHAFDNPAFEDDSEDQTDSGPKSSSSGLKKNRPWSGLLRSNAVADAWPALAEASSMGGKSCDESLPAVPTVRPGNAEMWAQPTMLMKSSASFKKDAEIDDPGQMQMFQKRTPPTTTEENPNRVIELPGSLVSFTDDAQLDDDNETVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2Y0</accession>
    <name>A0A914A2Y0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058192.1">
        <property type="nucleotide sequence ID" value="XM_038202264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202264.1">
        <property type="protein sequence ID" value="XP_038058192.1"/>
        <property type="gene ID" value="LOC119729619"/>
    </dbReference>
    <dbReference type="GeneID" id="119729619"/>
    <dbReference type="OMA" id="VPMADDM"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71796" checksum="D42B1E53A4FF6CF3" modified="2023-02-22" version="1">MAAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPSNTVFDAKRLIGRKFTDSTVQSDMKHWSFEVVDDGSKPKIQVEYKGESKTFYPEEISSMVLVKMKQTAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGAISGLNVLRIINEPTAAAIAYGLDKKVGKERTVLIFDLGGGTFDVSVLTIEDGIFEVKSTRGDTHLGGEDFDNRLVNHFIEQFQRKHKKNLQSNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELNADLFRSTIEPVSKAITDAKIEKNQVDEVVLVGGSTRIPKIQRILEDYFERKDLNKSINPDEAVAYGAAVQAAILHGDKSEEVQDLLLLDVAPLSLGLETAGGVMTSLIKRNSTIPTKNSQKFTTYSDNQTSVLIQVYEGERAMTKENNLLGKFELSSIPPAPRGVPQIDVTFDIDANGILNVSAQDTSTGRENKITITNDKGRLSKEEIEKMVSDAEKYKAEDDAQRDRIAAKNGLEGYAYNMKSTVEDEKLKDKISAEDKQTILDKCKEVLDWLDHNQTAEKDEFEDRQKELEGVCNPIVTKLYQAAGGAPGGMPGGMPGGMPGGMPGGMPGAGAAPDAGASSGGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4S9</accession>
    <name>A0A914A4S9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058554.1">
        <property type="nucleotide sequence ID" value="XM_038202626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202626.1">
        <property type="protein sequence ID" value="XP_038058554.1"/>
        <property type="gene ID" value="LOC119729833"/>
    </dbReference>
    <dbReference type="GeneID" id="119729833"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="17736" checksum="03C992B7302D5078" modified="2023-02-22" version="1">MTNSLPTIPAKSASLRASQLPAKVSPSKQPISQPANKPTFQLAARQPANQPASLKKPDCHYQANHIANLPTSHPQASSQPTSRQTSEQQANKPAHQPTSQPYGQPASQPSSQPSNKSASLPINHTSHPASQSSCHPASNHLNNQPAVTQYAYITRVELLARVMTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5M7</accession>
    <name>A0A914A5M7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058711.1">
        <property type="nucleotide sequence ID" value="XM_038202783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202783.1">
        <property type="protein sequence ID" value="XP_038058711.1"/>
        <property type="gene ID" value="LOC119729992"/>
    </dbReference>
    <dbReference type="GeneID" id="119729992"/>
    <dbReference type="OMA" id="ERTICFC"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="251"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="46138" checksum="00DE4C5744C42751" modified="2023-02-22" version="1">MATGGAAEVLGKIGERHLECSICLTHFAEPKFLDCLHTFCFNCLQNLRQGEDSQSVKLKCPLCRRETILGRKRVKDLPTNLTLSALVEEFTIQEQLLEGQGSEIKCQSCDENNPAISFCTECTHFICQDCHKAHARLGITKSHKTFTMAQLQSGEVAYKSKLREKPKCDKHANQNLNIYCNTCEQLVCTTCSVLKHENHYRADISEAFEACKQEIAELMIEGEEKKAILSNANECIAESRLKLDIMFESTNENISQKADKEVARIRALEQKIKKEAKNIYEDRVKTFETAKNNNNEELKEAKQTLDEVNQLMAQEIQTEILDLKPKLLHNFKELMKKQPENVSDKLHFIDFEEHDEMSLGQLLLGKDESESESPFNNPRLEHSYSCDVECQFESMSPGVSLEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A788</accession>
    <name>A0A914A788_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein N-terminal asparagine amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059319.1">
        <property type="nucleotide sequence ID" value="XM_038203391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A788"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203391.1">
        <property type="protein sequence ID" value="XP_038059319.1"/>
        <property type="gene ID" value="LOC119730471"/>
    </dbReference>
    <dbReference type="GeneID" id="119730471"/>
    <dbReference type="CTD" id="123803"/>
    <dbReference type="OMA" id="WRETFPM"/>
    <dbReference type="OrthoDB" id="539995at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34454" checksum="83D4AC08242911D0" modified="2023-02-22" version="1">MPLKYKDGSCVCTKKSKVEDLEKVIYLRFGDSSKWLQSQPLRCCPLPGLLYVDQREFAVTTVADDVIDTLGSDDATTCHIAVLRHSGSGATGLCHFDSCGTSQGVGDLVDRVSALSQDVDGRLELHIVGGFKDDDGSSEELSRKLLSEFHKLPVDVYLLTACISGLNNIVKNGVNHPILYGVGVSVKTGEIFPATFAYKGPDKQVRGLRHFIGDEKVINIYNHTDHRLRISPYSYRHTDFPHAAFFLQQSDQTIRQYLSTSPDVEPQHFAQQVKAAIAFFLSHPSSELVFPGGESRYFRMGQDGLWLPDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7I6</accession>
    <name>A0A914A7I6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059822.1">
        <property type="nucleotide sequence ID" value="XM_038203894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203894.1">
        <property type="protein sequence ID" value="XP_038059822.1"/>
        <property type="gene ID" value="LOC119730844"/>
    </dbReference>
    <dbReference type="GeneID" id="119730844"/>
    <dbReference type="OMA" id="SICICHK"/>
    <dbReference type="OrthoDB" id="1616686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="643" mass="72146" checksum="90DDD365B1A66280" modified="2023-02-22" version="1">MAEAAAQTVLDKISQGHLECPICCCRFKDPKILDCLHSFCLNCLEEMISKQKSEAEKITCPVCRRETQVPDGGLKGLSNSFVLRSLVDEFNQHEQVLGEASGPSQRCEECEEGFEAISRCLDCKANICKKCKEAHQHLKYTKHHRIVPMQDLVKSRSIPTNVTKTVTPTCREHIEQPLCFHCETCNQLICAMCAATEHRSSDHKYTTISDAMESFRESVNGILQKFKKIKEQFESNADSIKHARDRLQRKLAQGRCDISLKAEAEIAKIRSKAKFFTEKFDEIGQERDREYEKALMHNCDQVERADQIVTAVNDLMRQADDFELLELKPKVMHNLEFQKELKCEPAKLDMAFIGVKCQDIVSDSDLGEILLEEKWRLKEDFGKKGTGDGEFQFARGVTCFSNGDIVVCDTVLKQVSLFTSTGQFKTSIAQGAECHALEDPWSVAVNCDDLLFATDEDKVKVFNDEIQFVREFAPSGDDAEGLSESDLRCIAVDKQRVAVADFGRKVISVHNLDGSLIASTSNIMVRYYIAMSNKEQLTFTNYVEKRLLCVDFKGNEVFKVMPLLKGKPGRPTGVLCDDDGSIYVAVHSESGEFGDGEVQHYDSNGAFIATVVQGLYNPSEMAFTPAGDVVVADSHSVKIFKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A969</accession>
    <name>A0A914A969_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060387.1">
        <property type="nucleotide sequence ID" value="XM_038204459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A969"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204459.1">
        <property type="protein sequence ID" value="XP_038060387.1"/>
        <property type="gene ID" value="LOC119731312"/>
    </dbReference>
    <dbReference type="GeneID" id="119731312"/>
    <dbReference type="OMA" id="RINGMKE"/>
    <dbReference type="OrthoDB" id="7484295at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="280" mass="31454" checksum="8868F26C15112753" modified="2023-02-22" version="1">MPPKREKKQQSVSESTISPEAACAEPTVAHTIAVDDKSTTPAGNSLLAALRSEIRDMKSGIEGKLDLVISNQHSLLHRIDEIESRHTEIEKSVSYTSEAIEDVRAASTNQQSKLTKLTSELDVAESKITRLEETAIRLERYSRSYNLRFGGIAELPNERADYPYEKIKQILKEKCDMEPEIENAHRSGRPTQGKTRHILAKFMYRPERQAVLLKAKAALSGCGIYLIEDLPAADLIKKKSLKEIMHKAYVAGKKPIFRNGQLYINGQRFTPDLQPAPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA38</accession>
    <name>A0A914AA38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060269.1">
        <property type="nucleotide sequence ID" value="XM_038204341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204341.1">
        <property type="protein sequence ID" value="XP_038060269.1"/>
        <property type="gene ID" value="LOC119731249"/>
    </dbReference>
    <dbReference type="GeneID" id="119731249"/>
    <dbReference type="OMA" id="MARTECV"/>
    <dbReference type="OrthoDB" id="639466at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57235" checksum="4E04FA94AF8D08A8" modified="2023-02-22" version="1">MMSMIGTLVADGGSLLSSVPSLLLVGLTAVVAGTAIVGILGSRRPTGFPPGPTPIPFVGNVTSIRKDGQPVWINMGRLAKEYGDVFSIKLGDKWYVVLNSFRAIREGLAAGPVALANRPHFYSTDLFSEDYRDLGYTNYSPTWVLHRQFALGAFSDVYSTKHMDAVVNQQFTRYVEPLLASGGEGQSVDGIGLGQEMGMGSVVTWCFGPGNDQFHRDLVELVSVDVSLNLVGRRIPVDIFPFLRYFPLSSNRVMRDVVDKFMTMLRTEFKSRRQTFQEDDKLTDLCGALLHAQKAAEKEEKYDFLTDVHVIQVLASSFRGSIGLLTTTYWGLALLAEYPDVQQRVANEIRDVIGKDRQPSVEDRAAMPYTAATMMEMLRFGSVAPLGVPRAAHEDVKIRGFNIPKGTVILYNIYGTHFDQANYANPHEFNPDRFFDSDGSVIASPDNFLPFGMGTRKCLGYVLAQSVLFLAFSRLLQGYRVSKLDGQPGDGSLFGQDPQYEGSRWPKPFRIAITKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAP6</accession>
    <name>A0A914AAP6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060511.1">
        <property type="nucleotide sequence ID" value="XM_038204583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204583.1">
        <property type="protein sequence ID" value="XP_038060511.1"/>
        <property type="gene ID" value="LOC119731412"/>
    </dbReference>
    <dbReference type="GeneID" id="119731412"/>
    <dbReference type="OMA" id="KERIISW"/>
    <dbReference type="OrthoDB" id="6136178at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="166"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="274" mass="29369" checksum="466B9ACC05A21EC7" modified="2023-02-22" version="1">MNVYEVYRTSGPTSGSRFNEGLTTITYQARDGAGNVAYCYIRITVNVLRCPSVGSSSHRSHSCSKTNIAGSVCTFHCSTGYNLVGSSAVTCQTNRVWNRGFPTCQVRTCSPSLTNLANGQISCTNSNRWNSVCTFRCNTGYGLSSGGSTYTRTCSNSWSGTSPTCTDNRAPSITCPSSISVEAEDRLTSAVVSWVVPVASDNVPSGLTVTRTQGTAPGSRFNQGSHAIRYRAADAAGNTRDCTFSVTVRGMYLCIDPNEMHFSKSISYSVLMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADC9</accession>
    <name>A0A914ADC9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061349.1">
        <property type="nucleotide sequence ID" value="XM_038205421.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205421.1">
        <property type="protein sequence ID" value="XP_038061349.1"/>
        <property type="gene ID" value="LOC119732054"/>
    </dbReference>
    <dbReference type="GeneID" id="119732054"/>
    <dbReference type="OMA" id="EEHTHHR"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="660"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1391" mass="154306" checksum="13CB1824B272B3C6" modified="2023-02-22" version="1">MGDFWLQPLRSLSDLEDAKRAARHINDHSLAKMVTRKKKVRKSKKEAFQSVLLAPRFCQESIPPKSVVSSISTENQECSSKPCQKRQIQLFVNSSLTSPVCLQLHPSTAISALKGLLQDKVGIEPEKQHLFTRKNHELRDDLSLGNYGIEQDTNIELRLVSGLMGGADEQKTKGRKKTKRRQKKSTSTDKMSRQDNSNEEEQVRSPDESGHSPTSSTIEANASNQSTERKKTKRRTKKSGKKSTSTEEMDRQSNSNKEGQVRSTDESGDSPTTTSDQSTGRKKRRRRRRQNHVEKAQSCEEATISTSLDQDDQGDSQTCSSTAEFAVDSATNFTKLNLFLWILCLPLITIHVILSIWSPRMIQVTSSSKDGTNGRTSSGAEEQERSDDSGHSSTSAAKPGRKRTRRRRHGKARQNLLLDEAERQPTSDDKKQDHSDDLGKSYTSAGKPGKIRSRGKTKKKSGKIRKGKTVATKSPSEEEAIDETSKGDQAEDKFVNSRDSTVSSSAKTTAKRNNQSKGRKRTRRRRYGKARQKPLLDEAERQSTSDDVKRDPLEALGDSFTSAGKPGKIQSKCKTKKRSGKTSKGQKLAKKSPSEEEAIGKTSKGDQAENKLVNSRDSTVSSSAKTTAKRNNQPKGRKKTKKQTNADKKPSCEEKKESQIQLFVISSLRSPVCLQLHPSTTISALKGLLQDKMGIEPKKQRLYTRKNHELKGRMSLKELGIQQDTNIELRLVSGLMGGADDEQKSAGNSRERTSEDSRRRQKGKRKASRASCGGEDTCNNSSAVKPSAGHPSGETKQKLEQPRQYAPRRILKGKRRATKRRTSLGGEGNVDNSEDFSISIAVKATAGHPSVDTKKQKLEHPRKDDDSSRIQSGKSKAKTGTSLGGEKYLDNSEESFICSAVNAPTDNLSGEIQVHKVKQPRKDNNSGRRRKRKRKAANRSSSVGGEQSAGNSEDSSTSTAIKARAGQPSEGTREQIMEQPRKDNDSRRMQKGKSKAKAGTSVGGEGNSEESLMSSAVKAPTGLPSGKTQKRKINQLRNDNDSGRIQKRKRKANEARTNHGYEENAENLENSSTSSAIKAPADHLSRETKKQKLEQTSKDTNYGRRRKRKRKASNKSPSGAETKENMDNSEDSSKSSAVKAPPGHLSGETQEQKVEQPRKAKNSGRRRKRKRKAANKSPSGAETNKESLSDTEQQILRDPGDSCSSPTIGSAASTSPETVAGTIRKRERHEMAGSEAEESKKKTVASDRQQVAIDTGSSLVSTSVTASSVSRSRRRRRRRRRKNSEKKAIEVGGDSKVIDLERHQPKYWNVTGASDLNLQQDKGRTLELQRPKDQETEEIYNRQYTSSKTPGVRREDFGPDRLKADRHYEMSQKEHQRQGQDHVGELDIHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF78</accession>
    <name>A0A914AF78_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062511.1">
        <property type="nucleotide sequence ID" value="XM_038206583.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062579.1">
        <property type="nucleotide sequence ID" value="XM_038206651.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062625.1">
        <property type="nucleotide sequence ID" value="XM_038206697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF78"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206583.1">
        <property type="protein sequence ID" value="XP_038062511.1"/>
        <property type="gene ID" value="LOC119732973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206651.1">
        <property type="protein sequence ID" value="XP_038062579.1"/>
        <property type="gene ID" value="LOC119732973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206697.1">
        <property type="protein sequence ID" value="XP_038062625.1"/>
        <property type="gene ID" value="LOC119732973"/>
    </dbReference>
    <dbReference type="GeneID" id="119732973"/>
    <dbReference type="OMA" id="VANITCD"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275683" description="Protein sleepless" evidence="3">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16246" checksum="3E877FC7F3BDBECC" modified="2023-02-22" version="1">MRTLSVTSLVIVTWLTLPLITNSQDAQPSDIICYACTYRTVASAVVGAHCNDPINSAVSANITCDSMCMKRTYKGGVEQIRRGCYSDLREPGPCETYYDKPVPGSDPPETVTQVCCQESYCNHGNIHTLGLVTLILTMFSILLVKWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFV5</accession>
    <name>A0A914AFV5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor-binding cancer antigen expressed on SiSo cells</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062850.1">
        <property type="nucleotide sequence ID" value="XM_038206922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062851.1">
        <property type="nucleotide sequence ID" value="XM_038206923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206922.1">
        <property type="protein sequence ID" value="XP_038062850.1"/>
        <property type="gene ID" value="LOC119733333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206923.1">
        <property type="protein sequence ID" value="XP_038062851.1"/>
        <property type="gene ID" value="LOC119733333"/>
    </dbReference>
    <dbReference type="GeneID" id="119733333"/>
    <dbReference type="OMA" id="DMVPQIR"/>
    <dbReference type="OrthoDB" id="10017216at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034247">
        <property type="entry name" value="RCAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26185" checksum="0953831BB13494DB" modified="2023-02-22" version="1">MATFRCNKWFLCTFFVAVLGFLKRILFSRFHRRNKSDTDLPMLTGTISTPAAAGNSLDERNVDIADWDDWDYAGAPTGIIIEPNNPHTGPGTTPMGAAPMGGASVGGGVTADSDDVPEMDYFSDMAPTLKKTVLIRKKDRTRAGLPNSGMSNRLSMNVDITPIASSELSTWDEDNDGTWEDETSAVDLSWDADRVIKEKKQAERDRRSAEQHRKKMEREQQRAMKKDGGKLAVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH47</accession>
    <name>A0A914AH47_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063018.1">
        <property type="nucleotide sequence ID" value="XM_038207090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207090.1">
        <property type="protein sequence ID" value="XP_038063018.1"/>
        <property type="gene ID" value="LOC119733705"/>
    </dbReference>
    <dbReference type="GeneID" id="119733705"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="193" mass="21388" checksum="EE62F898637AB2E4" modified="2023-02-22" version="1">MEKIPINYCSYRDLATVPGVGDALATTIVDLRSAHGDITPEMLMSVPGVRSMPDIMRMFDFKSYIPFSEGSHPVNLAFPKSRFRRVPQATASAPSQMSSFQDAWSGLQGGTQKLDPLMSRFLESPYPFDSYPPHPPSPYAYSAHPREAHRLREEVPPVPFGQDAAATWSGNTAVSRIKKYALCWRDGVSGYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH81</accession>
    <name>A0A914AH81_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062881.1">
        <property type="nucleotide sequence ID" value="XM_038206953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206953.1">
        <property type="protein sequence ID" value="XP_038062881.1"/>
        <property type="gene ID" value="LOC119733368"/>
    </dbReference>
    <dbReference type="GeneID" id="119733368"/>
    <dbReference type="OMA" id="WELCWEL"/>
    <dbReference type="OrthoDB" id="6265224at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF57">
        <property type="entry name" value="BEE-MILK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="36795" checksum="EE23B8191E307775" modified="2023-02-22" version="1">MGLAVERFQYSLDTAREVTRTASDSDFLSLYPTISKDLKLLADQSMPKVDNRLAFLKFKPSEGVGGISLGEVVTEGKWELCWELGREGSGPGEFDGAWGIAPRQPDEIAVTDLYKRVVICGIDGNQKNTIPMQGRPLGIAATRSDNRLVVVEKGASHVKVFNSNNTLAYKFPTVPPSEVGKTAVDLRSVAVKNDGTIAVGDVARMVLTVHSPTDGELLHTIPVKIEPHFLAFHSNDQAIISDNTSHTVDIAGGNGTSKRTFKPIINGQPVCNCNGVCTDGSGIYVAMSNGFNTGHVHHYDPQGGFLKCIAQGLYYPLGITFSSHGQLAVADYNSVKMYRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI18</accession>
    <name>A0A914AI18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063186.1">
        <property type="nucleotide sequence ID" value="XM_038207258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207258.1">
        <property type="protein sequence ID" value="XP_038063186.1"/>
        <property type="gene ID" value="LOC119733894"/>
    </dbReference>
    <dbReference type="GeneID" id="119733894"/>
    <dbReference type="OMA" id="FEHICSA"/>
    <dbReference type="OrthoDB" id="10062286at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF250">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="193" mass="21808" checksum="AA6850A47F7320AD" modified="2023-02-22" version="1">MQLLATLRFFATGSYYTVHGDLHDISVPSATCDANYKLTIVVARWPGSTHNSAIIHGSILGQRFTNGQLTGVLLGDTGYALRPWLMTPILNPATNAERRYNRSHRKSRVVIEQTFGQLKRKFPCLALGMRMAPQRACVIIRACCVLFNLSKEFGQPDLEDGDDDNADENDELLYESHIHDGQLHRIMLINRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ42</accession>
    <name>A0A914AJ42_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064005.1">
        <property type="nucleotide sequence ID" value="XM_038208077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208077.1">
        <property type="protein sequence ID" value="XP_038064005.1"/>
        <property type="gene ID" value="LOC119734537"/>
    </dbReference>
    <dbReference type="GeneID" id="119734537"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="84" mass="9699" checksum="E5ACD8C9FAD9F64C" modified="2023-02-22" version="1">MNHGQFYYATKAFGVLQRLDPNPAYWEGKRGACVGVFQQIIAGHEPRETLRDILQILRNTGNPQVKYIIRVMKKWAKDNRVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJC5</accession>
    <name>A0A914AJC5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063661.1">
        <property type="nucleotide sequence ID" value="XM_038207733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063662.1">
        <property type="nucleotide sequence ID" value="XM_038207734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207733.1">
        <property type="protein sequence ID" value="XP_038063661.1"/>
        <property type="gene ID" value="LOC119734305"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207734.1">
        <property type="protein sequence ID" value="XP_038063662.1"/>
        <property type="gene ID" value="LOC119734305"/>
    </dbReference>
    <dbReference type="GeneID" id="119734305"/>
    <dbReference type="CTD" id="11266"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000056">
        <property type="entry name" value="Dual specificity phosphatase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36357" checksum="E0C6784E9FF3B134" modified="2023-02-22" version="1">MASSNVHTPHMDEICPGLFLGSESAVVTPEGQAAVLQHAITHVLSVADMKPKMGTLNLKHKFVRANDMPNVDILQHFEDCFGFIDDALREGKILVHCMMGVSRSSTIVIGYLMHRDKITFNEAFDMVRKQHPIAEPNYGFMDLLRLFEAMGCQFSSANPLYRQHRLGQVAENVQAGQEVPKEVIAADPQETTTDQTQTIYKCRKCRRAAFLEASVLAHITGRGQESFQWHKQSHPLSQGVTPSPSGTVDSSVTCTSLFVEPVKWMEPFMIGRLDGKLTCPKCSARLGSFKWSGLQCSCGAWVTPAFQIHQNRVDKATRRVQPTPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKL7</accession>
    <name>A0A914AKL7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064272.1">
        <property type="nucleotide sequence ID" value="XM_038208344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208344.1">
        <property type="protein sequence ID" value="XP_038064272.1"/>
        <property type="gene ID" value="LOC119734788"/>
    </dbReference>
    <dbReference type="GeneID" id="119734788"/>
    <dbReference type="OMA" id="ICPNSRR"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="467"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="642" mass="70679" checksum="B5EB5582334068BB" modified="2023-02-22" version="1">MAATVNVLLPNGRRQNVKVTANTRILQVIENVCGKIGLNPDEYNLKHIRSILDPQLSIRYANLPNNCKLELVKADRPRTESAVFIALQVESGERLQGEFAPPTSLWDILIHWETKNESMTGKLAASSQADDTGKAIHPVCIYLRQEIVGEAWLRATTLKSLGLTGGKAIIRLNHRAVDLPAPPSTQSAKTTPAIKIQQSSQASTCAPQGLPTSVSRGGDDTDTGTSQTSSQESRDTRLTLEVSKTKGAQNKNNSEPQDFQPESLSSDRPEPMDVEETTNASQPTPVGSRSHEGEREKRPQQTQPKQKGVIQQQSPSLELTPEMEQRANMMGAALAEAILKHRTEQQLAQLKQSWSAQPQPQPQYRPQFADFKFPQQPSSQSQPSLSPQQQSSKPPEPCERHPLVFSLDQVTGDPSDTSQDLPDKFFEVTVDDVRRMMADQQLHMSGSEDQHLQTKAMREAKALKKAQQYSQAAVRVHFSDRYVLQGFFRPLETIKALRDFIRGHLQDPGINFYLYTTPPRCILKDDSLSLFKANLFPAAVVHFGSEAAYDHYLRTDLLSEVTSFTKAKEEAASVVRSTSKDGARGTSGSSSSRIGQLGLSSGASTSKASAQGKKDGSSKRQATGEAAANSEKIPKWFKMGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKN4</accession>
    <name>A0A914AKN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064287.1">
        <property type="nucleotide sequence ID" value="XM_038208359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208359.1">
        <property type="protein sequence ID" value="XP_038064287.1"/>
        <property type="gene ID" value="LOC119734798"/>
    </dbReference>
    <dbReference type="GeneID" id="119734798"/>
    <dbReference type="OMA" id="CALEAMM"/>
    <dbReference type="OrthoDB" id="118154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03572">
        <property type="entry name" value="ENTH_like_Tepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035802">
        <property type="entry name" value="ENTH/VHS_tepsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039273">
        <property type="entry name" value="TEPSIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058028">
        <property type="entry name" value="Tepsin_VHS/ENTH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514:SF0">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25827">
        <property type="entry name" value="TVHS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="797" mass="85936" checksum="D3965E08DCCA94DC" modified="2023-02-22" version="1">MAASTVVSDVMGKVTFLHKFPTIIKATSDDDTPTPGYLYQEIADLTYVSSSYCKSLLDVLVDRLDKSSHHIKFKVLRVMKFVVENGSEEFHHSLLRRSTGIQLATKFSGPPDPLHGNAPYVAVRTAAKELSEVLFDTERSKNKEPSHNKEATVGRGLGTSRSGGSMEGFGNTGVPVHKQKSLGDTIKEGFRQLTDSFRESPATSTQSGPQSDYRPLGDLESDRGSSSSFSFLSRRQRTSSGAESAARQGEYKPVVVDDREGESPRVQSCQPSNRDVRRVTSAHKQGKPGGGWEDSSGGRGSNASNSDGQHSGGSTDLSERLESVSVEDVSMETKLVEDFATASDCKPTPSRDALAQFVKRCSTLNCEKVTELLGLELQSSSVPVQMRCLCALEAMMREDIASPEHLLGFIPNALKKLQVETTDRLLQAKASKILRQLERTHEEATASKISKAADDSTSNKNKDPIFGILQTDNSNNPQTTGTKGPQSSISNTKDSGHVPSHKDDVLLFNSVDTTPSVSKSSGSLFAGMEVGSAPKLEEPESQPIYQLDRISKHETHEVRNNKSGVIGKGDAQLFDGLLDLSSTDQPTLAPDLDANTQRYFNKNSSSLSKESSDSLLQFDDTETQKLKSPNTEEADHSSNGRALITESRHVTIETRVLSPKLEGTQSSTKPSKPDAIMSRSANFQDLIATTGIAVNGGNAKKAGPGPVGKSSANEPTQTSIVQTQTAAPNLNRDQISTLYPQLAGVALSGSSAVPLKLSQRPPEGNFAFVSPREEGKENSHRPGSFDFVKDAMLASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALG6</accession>
    <name>A0A914ALG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064592.1">
        <property type="nucleotide sequence ID" value="XM_038208664.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208664.1">
        <property type="protein sequence ID" value="XP_038064592.1"/>
        <property type="gene ID" value="LOC119734996"/>
    </dbReference>
    <dbReference type="GeneID" id="119734996"/>
    <dbReference type="OMA" id="YELEVCC"/>
    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13275">
        <property type="entry name" value="PH_M-RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039597">
        <property type="entry name" value="M-RIP_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1549"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1628" mass="182760" checksum="15B8137054BB89C1" modified="2023-02-22" version="1">MLDGDSPSPSKRTIERRKHANNRRGRHTVTIDSSMHVIPSSDESETNKDTPTLKRSNSDPNLADSDDMLKRKQIAMTFPGLFHLKKGWLIKQGDGEQDWSKHWFVLCDNKLSYYKDSSDEDPNSLDGVIELAKCNEASETPVNRNYGFQIELDTGVIILAAMTSGIRNNWVGAINKAIKTAREDSAKKSSEPTSLLKENQPLVSRTNKPNSLPLSKSTSDVQPREEQSSPLQPARRSLNNVDLIPPSSRLTQTDSKSATQSPVELKPHLERRSTSPSQPTKTSPSEGLPPHSGKPEGRRSSVTKAPSSESRPRRGSVPKEGASSTGARRNSVTKDPGMSADGKQKSVTRDRSGSDLTKPKEKSKERRGRRGSRSEKRSQEDTAAAVTAALSKRTSNTDSKQSTTVRKSRSNSQPEEPVTPSSNSEQEISPRSRTDSNSKKQPATVDTTVMSLLEQEVDTLKAQLEQKQKDCARLQHQNVNLKAQLNSEQRDHKESFQDLENEQSGYMTQIEQMEKTNQKLQAELRQSKNATQQLQQQNQQLGSKFNAVELEAQGRDRELATLKARFEDIVRDLTVTRSNLKEERERSETLETELTDTWTKLRESGREGVDVDVIGRLSIKLDEARVRLEESESDAIEKEKKLEERFSLMQSQYHSENASLQGRLQAAMDETNKLQRRLTEKSEQVEKTEAAVQKAGQTDKPSSETNVGVAELEATVQKLKSELKAEVTAKSEVQRKYDDLVAQSAHQFLEGQGDMASTGSDDNAVRLETELDLAERELEKLKKHSASEKEKKILLEKAFQKEQALRKQLEERIGQSTQESGSSKVDIEQKNSEVASVRDELKKAKKEREAVNLVRKQLVTAVDSLNSQLAEKERKIETLSAEVETRGSQNSQLEQQLQASLSKGLNLQSRVENLEAELKQVSEKRETDASAQLGALQSEHRQLKRQIGTLEEQHALEMHNRQSELETAGDRINSLQDKVAELEIKLKTAMERAARIEDEAAASILDMQKEDELLRSKCERGEKEIKRLRGELHGAQDNYDELEFQFITQREDLKRMEHDRGKEIGQMGYRIQDLTNKLAAAERKVRDLRGVDHRNRAKGGVGAAGGMGMQLTQTRQMENKLKELESKLGDVESTLQDQDQDTTSLLGKIVSVEQQVQARAQLPSSSSVSSVDAEHQLQSQAVQPLSRGSSAASVPCDSVSTSGADLSEDSEPAESPDRAKQNFRARFLETKLSETELKLKEVTRKLVDVTTRELENRKAYQGKSVSESRLKEKLKVMEREVEAVTKELQQTRNNGDLVLQEKSHREILEEMRRSHNQEIKALEEEKETELEEERKATSISITALHKAHKHELEQQRADMQQNVSNDVEVVMKRHREVITKMDQEWKIISDKFTHVCANNATLKKQVETLEKGLVETRREMESWKAQVRLLVGQKAEDMAALKEQRGGGAGNDGEEEEGGQDDWGVDGNDNEKNPLQVLLRFREAELQCINNEINQLTAALEEAEKQRTKAIEQNVFLEGQHQSQEEHIKQLMLALEELQHQVEIVRTSGEGQAAQDQIQEMSGAEGSSSQHNPPQGSGDAKQDVKLRSWLPFLKRERSDSAGKGSRRRTGSDGTQTAAKLKKGASTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANV5</accession>
    <name>A0A914ANV5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065119.1">
        <property type="nucleotide sequence ID" value="XM_038209191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209191.1">
        <property type="protein sequence ID" value="XP_038065119.1"/>
        <property type="gene ID" value="LOC119735486"/>
    </dbReference>
    <dbReference type="GeneID" id="119735486"/>
    <dbReference type="OMA" id="PFFNCED"/>
    <dbReference type="OrthoDB" id="10181928at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037965529" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="79" mass="8653" checksum="C2AA7604A7E4F572" modified="2023-02-22" version="1">MAAKMFFVILALAVLTAFVMASEEDEDFADHEALYEMVKRGRKGRKGARGNPFFNCEDEFGNPGCVCDRRKGGVAVTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APD5</accession>
    <name>A0A914APD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065335.1">
        <property type="nucleotide sequence ID" value="XM_038209407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065336.1">
        <property type="nucleotide sequence ID" value="XM_038209408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209407.1">
        <property type="protein sequence ID" value="XP_038065335.1"/>
        <property type="gene ID" value="LOC119735624"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209408.1">
        <property type="protein sequence ID" value="XP_038065336.1"/>
        <property type="gene ID" value="LOC119735624"/>
    </dbReference>
    <dbReference type="GeneID" id="119735624"/>
    <dbReference type="OMA" id="STAHYKG"/>
    <dbReference type="OrthoDB" id="10533533at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324124" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29116" checksum="E2BC09AC114F3E39" modified="2023-02-22" version="1">MGRLHAPSIDAVMLASSVFALVTIHVAQATAVTTSSTPAKVKPSASYKAKPSSSTPTVLSLQERLEMLKKVLPDYGVFNQGTSMPFDESWKIDEWSAETVAPWLNPDGSFDSQFNPNVDADDFNIPTMKPFHFDFDDNDFHKHDDLFNANSSGMGSYTWITMAVVLVVFFKVTVIAVMIARRMRYRQHRVVVRSSNSNSVTVPSEFTSDQAHLVTPANIVYVDTVGAAPPPLPQMFTPPPYCESLLPNSQGGPTTPTEEPPPYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR83</accession>
    <name>A0A914AR83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Single-stranded DNA-binding protein 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066565.1">
        <property type="nucleotide sequence ID" value="XM_038210637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210637.1">
        <property type="protein sequence ID" value="XP_038066565.1"/>
        <property type="gene ID" value="LOC119736624"/>
    </dbReference>
    <dbReference type="GeneID" id="119736624"/>
    <dbReference type="OMA" id="NNMTGMS"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04503">
        <property type="entry name" value="SSDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28639" checksum="1FC9D8CF91DC773F" modified="2023-02-22" version="1">MSGTHFAISYNILRFLPDTGFFVPSGFFAVKKEGHPSMGGPMPRMNHPRMPMQPNGSFSPQNYGGGMRPPPGSMPGGMPLPMPGGRPWNPNTSTINYSRASPGGFVGPPGSGGPPGTPIMPSPQGNPQAMSSDRRMSQGSSRRDSTNSGDNMYTMMKPVPGGNMGPGNFPMGSGPDGPMPMGSQDIPPVMNGEMDGLPKSSPASNQGPGGPGTPREDNGDMSGQLFPNFQDNDQNESAAILKIKETMQEEAKRFEKETPGEHPDYFMHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARM5</accession>
    <name>A0A914ARM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066099.1">
        <property type="nucleotide sequence ID" value="XM_038210171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210171.1">
        <property type="protein sequence ID" value="XP_038066099.1"/>
        <property type="gene ID" value="LOC119736154"/>
    </dbReference>
    <dbReference type="GeneID" id="119736154"/>
    <dbReference type="OrthoDB" id="10164190at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036758271" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="192"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="50166" checksum="AEC4242EFE04CB0E" modified="2023-02-22" version="1">MVKMVYLMVLLALLGGAMADTNNNKPEARMVILPLTASTGRFNKVYATFDGTVYEANIPNVWAPTAETVLVVMNVTDVPTEETAIIPDSDSDEPTRFGSPVIGLDVITASGEKISADFDEAPIEVIFPRQECLSEETIVCAHQPAENKQWYANGCRVSSVTKDDVTCSCGFLANYALLLQPYKVEMTNSRSMNLLTSVNMTVTVASLCIVLLAYKYSRLTSSRTVTHASLSLAMVALYSTVFFRDDEKPVICTTVAILFHFFMQATFIWMALAGALFYLTSHDEHTSTSRIRPRALLLTGWGFAVVGMVASFASGLCGCATSTGSCWLSSGEAFVWELMGPIVYMLVIKTLITCRLTRWGGLQERKLSNQETVKIRSGLQVASVLEPLVCLLWILGHSYLPDGNLFFTNAFVTLNSLQAFFVFYTSLLEEDKSYLEEDVATKLHKTVDSGTISVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATR1</accession>
    <name>A0A914ATR1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038067058.1">
        <property type="nucleotide sequence ID" value="XM_038211130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211130.1">
        <property type="protein sequence ID" value="XP_038067058.1"/>
        <property type="gene ID" value="LOC119737054"/>
    </dbReference>
    <dbReference type="GeneID" id="119737054"/>
    <dbReference type="CTD" id="646625"/>
    <dbReference type="OMA" id="RCQNERA"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3330.10:FF:000001">
        <property type="entry name" value="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="13">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="19536" checksum="4BCD3D9D6950B025" modified="2023-02-22" version="1">MDEVNSLSWEAFIQRFGNVIEHGPIVAGAIWTQRPFSDARELHRAVCGFLDTLPSTGKESILRCHPDLAGALARADRLTTESKKEQRGAGLLNLTKEEAAIITELNISYKSKFQFPFVICARENKKEAIIAGLKARINNTVDVELQHGIGEVKKIAWYRILDLVPTASDQMIAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU41</accession>
    <name>A0A914AU41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067580.1">
        <property type="nucleotide sequence ID" value="XM_038211652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211652.1">
        <property type="protein sequence ID" value="XP_038067580.1"/>
        <property type="gene ID" value="LOC119737355"/>
    </dbReference>
    <dbReference type="GeneID" id="119737355"/>
    <dbReference type="CTD" id="56975"/>
    <dbReference type="OMA" id="NNICFVG"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF22">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN CG31145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="11">
        <location>
            <begin position="337"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="582" mass="66822" checksum="39B035A8B5B7CFFB" modified="2023-02-22" version="1">MKTGIICGICRGSMKLKQRAVAVMVGTAITTALVLMILTVDLKPVSMFYQSVRVQSVQGGPVVEDGQQVRAGDHPVHLRRQLGKSASRSGGTAANLTVARHTHELDPLADSAGRHEHKDTAYRKTNSRTNAEGPAHPRDPRTRRTRPKGFPDEGNFYNSDHKWLRTQPEQTKPNTGKYEKLMSLPSAVSVPSKTEKLIRLKKPKGKHEFKILESFQLGINRFEVYSNTSVIDDLLEYLMTHPIYEVDEKSGGTQVKLILTFEDGGHALFKPWRVPREYETLPNHFYFSDIERHNAEIAAFHLDRILDFRRAPPVAGRWFNLTADIYDLADSGLRKTFFRSPANNICFVGHCSYYCETETAVCGKPDMIEGSVAAYLPSFKAAPRKTWRHPWRRSYSKHRTAVWEQDPTYCERSVMTKHPYKTGRRLLDLMDMSVYDFLIGNMDRHHYETFEAFGNFTFPIHLDHGRAFGKHHQDELSILAPLFQCCLLRESTYKRLQLLATEEYLLSDVMRESLSRDMIFPVLLEAHLEALDRRLQTILAQVRRCISRKSEKAVLKPEPRMEDYKEPEPSAKTGETYEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU59</accession>
    <name>A0A914AU59_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of nonsense transcripts 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Up-frameshift suppressor 2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066846.1">
        <property type="nucleotide sequence ID" value="XM_038210918.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210918.1">
        <property type="protein sequence ID" value="XP_038066846.1"/>
        <property type="gene ID" value="LOC119736896"/>
    </dbReference>
    <dbReference type="GeneID" id="119736896"/>
    <dbReference type="CTD" id="26019"/>
    <dbReference type="OMA" id="IWPDEDT"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000014">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000015">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000023">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="709"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1586"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1832"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1108"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1618"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1646"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1859"/>
            <end position="1868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1868" mass="209612" checksum="6B947BFD608CD7F9" modified="2023-02-22" version="1">MADKIDDKDSASTKDAMMEDESTGIPPDKNVMDEGGDNASSTEEGTKDSASSEFESKSSGDATQDAKEEVLQGEHPQYEGNDAVGESLEAKADSSCSVKSSPLQEEISSPKSQEDLSASVAEDGGCMSEKDAGNEAGGDASMVTEVTPIDDAGNEMEGCAPDVLNIDQEDGTSNTSSGDIETKSASDHRGEKVDSGKEEDLVGDSGTILESSQTVAGKGNIPELPVEAGKTETVTIKEPKADDGEDVSKQNCPNIDQSEMDSTKETAKGDGGDLEAPKDKPNKNKVGATETSKPVIVFPNPEANATETAQVVTTPKRASNQFDTANANNNAKGQSSGSKGDDKKLVENKRSSTSDAKSVSKSSSKSDASPPDTRERAGKSYSAQRSANRSSRKGGMPDPKPQDKQSTSKQTEGDPRADSRGRNKQEEAQKAKGRQASDQGREKTSSGGNRPKDKDQDRPGYREGEKKSSDRRRDRDAAKDRDAGRDRVAGRDKDSARGRDAARDRDAGRDKDSARDRDARRDRDAARGRDAARDRDAARDRDAARDRDAARDRDAVRGRDAGRDKDSARDRDSVRDRDSARGRDAAKDRDAGRDGSKRSGEATAATKKPAKTKEEIEREEAALKKKEEELRKAEEERKAAEMKKQEEEEQRLLEEENKRLAEEEQKHAMETWTEANERKQAKMELRAKNLAAAAERPDEDFFVKLDSSMKKNTAFVRKLKTMTEQQRDSLTAEFNGLNLTKYVGEVATTIVESKFKMVDIGCAVHVCSLMHQRYAEFSSQLQQVIQKCHPAQAKKDEQKETKKESVVFDSRIRVELRFLAELIVAGVFTEKEGLPALNTLLSSVLKADKDNHTHISIIISFLKHCGEDFAGLVPRRNRLLAEKFNLTLPSSEIFPAQRKSAYKALLKDHYLSLTKHLLKEHRDLQNMEKHNRRTLQTKGELSEDRRRRHGERQSSYQKLLVNTSTYADLIDEVVPDLPEAEITPEEREMMALDYLGSDKSGAEFDFDTSLWEDEDTRTFHENLIDLRTMVPGILFKDSEKKGSPDEKQEDLDKLGEDIVALEDTEGAELVTEEEAEAAEMAPEGEIEGATEEDMTVEDIETTSVSSETEQEDTEEEEEETEQVTNMSKKMLLDAYLQRLPQCVNRDFIDKAAVEFCMDLNTKINRRKLIKALFSVPRTRLDLLPFYSRLVATLYPCMPDIGMELVEKLKADFRWHVRKKDQMMIESKIKSVRFIGELTKFRMCPKSDTLQCVKVLLQDFRHHNIDMVCNLLDSCGRFLYRSSDSHLLTKALLELMMRKRSKLHLIERHSTMVENSFFYCNPPDVKQAEKKERPVMHQYIRKLIYRDLSKTTTEKVLKQLRKMDWNNTEIKTYITKCLSNVWNVKFNNIHCVASLLAGLVPYHDDVGIQVVDAVLEDIRIGMEINHAKFNQRRVSVVKFLGELYNYRMVESAVIFKTLYSIIRFGITLDGAENPLDPPEHLFRLRLVCTLLDTCGQFFDRGTSKKKLDCFLVYFQQYIMYKRSLPIWNPLVHPFPLDNDNALADTLETVRPKLKICATLEEANEAVAELEKEQVQKHGGIIQMALASVNPQPPGSQQLGTITEGDETRTTAAVEFTSITEDEEFSDSDSESEGVSRRGGGGGREGHTTSSQSQGHSQNTGDEEGTDDQMALDSAGETEEDDTVTVLTGGPKLIKCDEDDDFTSEFDKMLSDSVQQRNVDTIKVPQQDIAIPAQARPRPKKMTFDIFSPDDEDDNEEEEQAESVNFVLMMRRGNKQHYHEFEVPKSSELAANLRNREKLELAEKKRLKELTLNINDRQEEEDYQEMLAQFQKPATVVPPVVPKERKPRFHHPKGAPDADQIFNSSGNRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUN4</accession>
    <name>A0A914AUN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Hyalin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067477.1">
        <property type="nucleotide sequence ID" value="XM_038211549.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211549.1">
        <property type="protein sequence ID" value="XP_038067477.1"/>
        <property type="gene ID" value="LOC119737309"/>
    </dbReference>
    <dbReference type="GeneID" id="119737309"/>
    <dbReference type="OMA" id="CNFIVQV"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037157014" description="Hyalin" evidence="11">
        <location>
            <begin position="26"/>
            <end position="3917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3879"/>
            <end position="3900"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="291"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="376"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="462"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="636"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="721"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="806"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="889"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="974"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1057"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1310"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1393"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1478"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1561"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1646"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1729"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1814"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1897"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1985"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="2072"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="2159"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2243"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2366"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2408"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2452"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2498"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2551"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2598"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="2638"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="2722"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="2805"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2891"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3023"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3155"/>
            <end position="3188"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3191"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3323"/>
            <end position="3359"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3458"/>
            <end position="3494"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3590"/>
            <end position="3626"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3721"/>
            <end position="3757"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="3799"/>
            <end position="3840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1255"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1423"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1591"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2752"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1255"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1269"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1437"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1599"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2272"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2395"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2437"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2461"/>
            <end position="2478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2480"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2533"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2585"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2624"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2917"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3049"/>
            <end position="3058"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3217"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3349"/>
            <end position="3358"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3484"/>
            <end position="3493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3616"/>
            <end position="3625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3747"/>
            <end position="3756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="3830"/>
            <end position="3839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3917" mass="405140" checksum="73EA8178685DE0CA" modified="2023-02-22" version="1">MAATGYLSVAAVLLTVACMTKPALSQDVVPPQLFGCSVVDIAGTPVSTTAQTSTGTWQTPSGFNLQPGQSFTTPFETANIYGQLSGTTPFNYGFTTVGYRFVDNPPTSPPQNNAYCTFFVRVGVNNDGTIPTVLNCPGSITQPIASSQTTAAVSWTEPTATDNNGVVRRSWRSHAPNTAFPVGTTQVTYQWIDPSNANSQAQCMFTVTVSTTGTDGVVPSLTCPADVVASAGGIATWTPPTPTDASGIVSTTSTLTPGSVVQEGFTTVTYNTVDGTGNRASCSFIVRRIPSDQYSPVITSCPTNIDQTVTSGTSGFVTWTEPTAYDDGGHVRLVMQTHSPNTAFPVGTTPVEYRFQDTREQVARCVFTVVITVTGGDTTPPTFTNCPTTSQVFTITSGSTAFVSWAVPQATDNQGTPTVTQIQGVSPGTNLAAGQYTIRYQAQDAAGNNAFCMFTVLVQQGGDTTPPTFTNCPTTSQVFTITSGSTAFVSWAVPQATDNQGTPTVTQIQGVSPGTNLAAGQYTIRYQAQDAAGNNAFCMFTVLVQQAAIFEITCRASLDIITSTAQTIQLEQPLVSGNTGAVTFVYTAISGGTTVPVTNNMVTVGSPSSTNVFIVGTDTQSGRTDSCSYTITVGAGDTTPPSIFCPTVADVTVSTGNNNGATVTWATPQASDNSGTPTVALFPPTQSGPGSFFVFGSYTITYRATDAVGLTADCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTIARTSGPPSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPSIFCPTVADVTVSTGNNNGATVNWATPPAFDDIGTPTVALFPPTQNGPGSFFVFGSYTITYRATNAAGLTTDCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTIARTSGPPSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPSIFCPTVADVTVSTGNNNGATVNWATPPAFDDIGTPTVALFPPTQNGPGSFFVFGSYTITYRATNAAGLTTDCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTIARTSGPPSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPSIFCPTVADVTVSTGNNNGATVNWATPPAFDDIGTPTVALFPPTQNGPGSFFVFGSYTITYRATNAAGLTTDCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTIAQTSGPTSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPSIFCPTVADVTVSTGNDNGATVNWATPPAFDDFGTPTVALFPPTQNGPGSFFVFGSYTITYRATNAAGLTTDCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTIAQTSGPTSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPSIFCPTVADVTVSTGNDNGATVNWATPPAFDDFGTPTVALFPNTQNGPGSFFVFGSYTITYRATNAAGLTTDCSVTFSVVDRVNPVPNCPANIMQAIGVNQNIVTWPTPSGSDNSQVTPTITQTSGPTSGSTFTPGTTTTIVYTATDQAGNSGTCSFTVQITGDTTPPQIFCPTVADVLVSTGTDNGATVNWATPQAFDDFGTPTVALFPNTQNGPGSFFVFGSYAITYRATNAAGLTADCDVTFSVVDRVPPVITCPINVQQEAGINGNRVVWTPATATDNTLLTPTVTKVQGPDSGSVFTPGTTTVIVYTATDVNGNSASCTFSVEITNDVTSPTITCPVVPDVVINTGTADGATVNWATPSAFDNNGVPTVALFPPGQSGPGTFFRFGSYSITYRATDQAGNIADCTITFAVVDRVPPVFVCPTTPVTETIPVGSNQVVIQFPTPTATDNSGFPPTVRLQDGSQGPGQPYGPGTFTVTYVATDGAGNEALCSFPVTVQPGVDITPPVVTVCPANIVRTVELGSGDTVQVTWDLPTATDDSGSPVNVVLQTGLAPGSSFSAGVYEIVYRISDNSGNFVNCEFCVVVNTVDRMNPSITCPADITRTVELGTASGSLVSWQQPTVGDSSGGPVFVTLLTDRPSGSYFPAGAPIVVSYQAADVTGNTDTCSFTVTVTVVDTTAPVFTYCPSTIQYSVLDFPAEGILVSWAEPQFYDASNSATISDRTPAAGTRFTNPSTQVSYTVRDAGGRTAVCSFQVNIFVQNPCTVSPCQNGGNCVPTGRGTNDYNCVCPPCFSGQNCQLGVNPCANNMCASGSVCVPVAGSCVDYTCQCSTCNYGRFCDQQVDACANHKCENGGVCSAFGSSCLQYSCACSGCFRGATCNEVFNPCSASPCQNSGVCSAVQNSCTAYSCRCLGCFTGYNCQLAVPSLCLPNPCQNNGVCMLRANTCYDYVCQCSSGFTGLHCEAIIMRSNPCNSFPCLNGADCINMDGDFAYTCKCQSGYTGINCGVSISDVGAASACASNPCQSGSTCSNSYHSSSPQIYQAQYVCNCNTFLTGMNCNTPTTNAPTMNVCGSLPRPCANGGTCNNIYNSYLQSVDYWCRCQPSFFGQHCEIPYANPCVPNPCLNGGTCSSSDRSFTCQCAAGFSGNLCETQAGDTTPPQVFNCPSDFAFDAGSQSVVNVPWTEPQVFGGTLFYQTHTPNSTPFQTGTSTRVIYVFADAAGNLAKCSFNVLVTGSAVTDNSMPSITCPNAPTAIISGDATTVRVTWSPPIASDNQGPPLVSSDRLSGSPFPEGMTPVTYTATDYSGNRATCTFQVTVTRQGGFTVQCPNPVSIPADAGQDCTTYTLPNPTYSNNVGAVTLGYRLIGGSATGQNFYTTLPFSGSFRYRAVDSNGNVAECTFVLSITPGVDPCSPNPCQNGGQCSVAVNTFSCQCPTGFTGTTCENPTGGFQITCQPQVSVSGTPNSPVNVNIPEPTAFGNTGQVFYTFVANNVQISNPRAYQVTAPASGQFTVPVSVTAFDSGTNQQRTCQINIVVTAAGVTPCAINPCQNGGTCNVNGNTFSCTCAGGFSGTTCTIPPTGFQITCQAPVSVSGTPGSTVTVQLPEPTATGNTGTVTFFFFADGVQVNSPMMYQASVPASGQTTVNLQIYGVDSATSQTTNCMTQVIVTGGGVSPCASGPCLNGGTCNVQGQAWTCTCPTGFSGSNCQLDPCSVAPCLNGGVCSVNGNTFSCACQNGFTGDICQTAPGGFQITCQPQVSVSGTPNSPVSVNIPQPTASGNTGQVFYTYRVNNVQISNPRAYQVTAPASGQSTVPVSVTAFEAGTNQQRTCQINIVVTASGVNPCAINPCQNGGTCNVNGNTFSCICAGGFSGSTCTIPPTGFQITCQAPVTVSGTPGSTITVQLPEPTATGNTGTVAFFFFADGAQVNSPMMYQASVPAFAGQSNTVSVLIYGRDSVTGTTRDCMTDVIVTASGSTNPCTINPCQNGGTCSVNGNTFSCTCAAGFSGTTCTIPTTGFQITCQPQVSVSGTAGSTVNVNIPEPTASGNTGQVFYNYRVNNVIISNPRAYQVTAPASGQSTVPVSVTAFDGGSSQQRTCQINIVVTAAGVNPCAINPCQNGGTCNVNGNTFSCTCAAGFSGSTCTQITSFQITCQPQVSVSGTPGSAVSVNIPEPTASGNTQQVFYTYVANNVQISTPRSYQVIVPASGQSTVPVSVTAFQSGTTQQRTCQINIVVTAVAGGPCNPSPCQNGGTCNVVGTSFMCTCTSAWVESICATPNPCNSNPCPAVDMECYYAQNSYVCGPAQTGRRRRDAAEGDVSLCDQYPCFNNGTCVSGVDEEIGDYMRCDCAPGWVGPSCEQEQVELDQPDRPSWMIQQPPDWMDHSPARWGKEKLGMHWMMVGVIAILALVVVLMACAFMRLTPRKRSRFDGVKLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW87</accession>
    <name>A0A914AW87_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068365.1">
        <property type="nucleotide sequence ID" value="XM_038212437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212437.1">
        <property type="protein sequence ID" value="XP_038068365.1"/>
        <property type="gene ID" value="LOC119737818"/>
    </dbReference>
    <dbReference type="GeneID" id="119737818"/>
    <dbReference type="OMA" id="CIMVSVR"/>
    <dbReference type="OrthoDB" id="10497616at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="819" mass="89124" checksum="A322571707FDE94C" modified="2023-02-22" version="1">MSRNLQSEKDKENDVHSTQSNLNLAGGRSSGCNMDLKLQNQLSKYLSPEFDVSINDVGEIVNILNVIKAKCASTPEKFRLLIGLLCEVDLSITNIEEHYEQLLVKNRIFHLLRMFPNVAHPLLDVIARVTNRCCPLASLPVTIGRIEEERQARNNKFLITCNNTVMPGTAQLLQHSTCLRLSAHQNNPTTEVPVTGIRQAGVLSPHRLSVVTQPTAHAPSVRVVTVTSPAGQPLVGGNQLTEFDMSRRMYDQVPPSLLHSSLPGGVVNSSGARESPTDIQKRILLQQQQRLRLQLELLQAQRLQQACLRNLTFGHQKTSNAAVCTIPNTPMAIMEQPVPASSTVIGPLKSSARPMRMTRSCSQLSQQPIRGAVGNRQSGRDIQALDLRSPERRLASENVSSKSITATLNTNCETVPEKLSVKAAKNDDESGNAEKEDATCEKEGELCLSQVGQHCIMVSVRDGSNSSHEGSVCETSTPQKGSGLGVEPAKCKTRQKHRKGRAGHGCRGAVINVKKLCHMQDAETSKKHKNNSTASRDKRSPTAETSVQELKRNTESRRGHGSCAASSNLANVNNNSNNKCDSDSQDCLTQPHGLNSSRKRKSKRTSKSSKRQRKSSSGIDVLRGIIVSDSEPVVNNSAIAFEAGKESVPLDLSCTLTPTKNMGNLTATNAAFEPTTGLWQRKPDDEHVNTINQSQRQGFEFSQIPEVRSPESAYLLYSGCDDEAWYQSSQSDEVDILSNQSSASPAAGQSNASMSSPMQPGSFFARLVHSEQQKSLAAVGNGTRRSAAASAVAAAKTALLPAVKRNLPRTRPDKKKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWF1</accession>
    <name>A0A914AWF1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068072.1">
        <property type="nucleotide sequence ID" value="XM_038212144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212144.1">
        <property type="protein sequence ID" value="XP_038068072.1"/>
        <property type="gene ID" value="LOC119737651"/>
    </dbReference>
    <dbReference type="GeneID" id="119737651"/>
    <dbReference type="OMA" id="LTTWERQ"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037435118" evidence="20">
        <location>
            <begin position="25"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="435"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="445"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="868"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="764"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="913" mass="102610" checksum="1B27FD4EF4B27B4B" modified="2023-02-22" version="1">MLSQTVKVLWSVVLLQLYVHRGDAGVVSIAALFGTESTDVKSVIQDGVQYINRNTSILSEVHSIEYTGIVGVKTSNSVFSALDDVCNLISGERPSAMILPEDKCPDCEDIAGIASHASNPVFSLDHGSYDSGSLAFKMHPSPEDTNNLFVDILEYFEWRNFIIVHDGGNALEFLQEVLNIQRVNEWNITAIELGERGNHEGYMELAGKIKAESSRNLFLFCSSEANAKAFIVWAQANPSAQILNAKYHWVLGNIDISLDRTFRTELEKTNAYITRFGMNYTREIQYAQPTSISTSTTEWPMRNRLAFDAVIAVGHALRLYREWREDNGESGTAVLPGDTQMPPCPTSSATPTENALSRYLKQVAFEGISGNVEFDSKGNRVNYTISIYSGQFRTLDQMRGEWTQNKAYWEQKWKRKWESEGHLNVTYHNYASERTIKIVTIESKPFLMLKGNDTLTDQGSYAGNNRFEGYIIDLMERIKTHIKGIDFDYQVELVADGKFGSSHPYSKIWDGMVGDVVRKKADIAAGPLTVTPDRAAAIDFTYPFMSSGITILMKHPNYVQHNPFRIMYPFGIEVWFINLVAFFIISAMLYFFNYFDPYEWRAAAERRETFEENAENFTMKNSLWFATTTMFLQSFDASPRSNAGRCLAAFWWVFTIIMVFLYLLNLTHFVTTNKRLAYAKTAEDLLDQTEVAFGSVEKGSTYFYFKKSSVPEFQRLWQHMNTRIPSPWVKNVPEGIQRVRDSNGYYAFIGEAGELNFLASKRPCDLLVSGTYITRTTYALAVQKGSPLRDQLSSAIESLRDTGVLEDLEREWWDLDIRHQECANLTTWERQGVFSLTTVDLQGVYYILVIGIILAAVTFILESISYSCSGGKKKSSSSARNGGMGGGMSGPRGGGGGAVGGPASGGGDEKMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYQ2</accession>
    <name>A0A914AYQ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038068386.1">
        <property type="nucleotide sequence ID" value="XM_038212458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212458.1">
        <property type="protein sequence ID" value="XP_038068386.1"/>
        <property type="gene ID" value="LOC119737837"/>
    </dbReference>
    <dbReference type="GeneID" id="119737837"/>
    <dbReference type="OMA" id="CYLVWMS"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="151" mass="17344" checksum="E344BA0674BC8DC8" modified="2023-02-22" version="1">MAGYSELLSFMDIPVFRLYATYAAAVTLKMMFLSAWTARFRLSRKVFMNLEDAEGKKERVREDEDIERIRRCHRNDLENIVPFLVLGLLYVLTGPSVYAAAWHFRAFVASRFAHTVVYLMHVPQPTRFLACLVGYGVNVSFAVQVIMNGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZV7</accession>
    <name>A0A914AZV7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069059.1">
        <property type="nucleotide sequence ID" value="XM_038213131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213131.1">
        <property type="protein sequence ID" value="XP_038069059.1"/>
        <property type="gene ID" value="LOC119738291"/>
    </dbReference>
    <dbReference type="GeneID" id="119738291"/>
    <dbReference type="OrthoDB" id="5950113at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036989002" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="34720" checksum="B5CD53DF8C5E5C2F" modified="2023-02-22" version="1">MQQIFAVFLSFTCYALANAFFRPYCQENATCVRGCSWVLERYFNGVANQVLPDNGYRNLTVPSLAMCGRECLMDDRCFSFHYSKGEMWCELNGATASRYPMDLIEMEGMFYYGPEEPKLVKLLASGNKTGIPSLTDCRYQTHGSVSPECSKTGQHLCLKWELDHASKEGYPATPLSWYADPDSQAVLTETGVTYHDLPLTAPSPGLCCSLPMTYRDPVITPQSYDLADRAGQARGCSDLAAHPCTLAELKEAYDHGYRGCLYWGYFATPNRDARVDGCTHHKDDECYQGTIANTPRPATHKRVYCCPNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0Q9</accession>
    <name>A0A914B0Q9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc phosphodiesterase ELAC protein 2</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ElaC homolog protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ribonuclease Z 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">tRNA 3 endonuclease 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">tRNase Z 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer. Interacts with PTCD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038069577.1">
        <property type="nucleotide sequence ID" value="XM_038213649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0Q9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213649.1">
        <property type="protein sequence ID" value="XP_038069577.1"/>
        <property type="gene ID" value="LOC119738712"/>
    </dbReference>
    <dbReference type="GeneID" id="119738712"/>
    <dbReference type="CTD" id="60528"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000014">
        <property type="entry name" value="Zinc phosphodiesterase ELAC protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="25">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="283"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="961" mass="108548" checksum="4915330BCCC673EF" modified="2023-02-22" version="1">MFTTRKSHAINLGEKLKTDQMFSPKLHHFVSLVSQESFTRVACCHRNVSCFAGVLGRLSLARGKPETEVRQLASLRTRLLVSSAPLFTCRTFPVSSYVQTRHHFQFPENRHQPILTPTKKMAEAQRQSFRAKHQKRHRRFEGAEVQERKLDRQGKVSIQVTGSGTRACPPSVLVIADSGRYLFNCGEGTQRLMFENRLRSLAKLEHIFYTRMAWENLGGSIGMMITLKNVGLPKLSLYGPQELTEFSKALQIFAKHEAIDLDVKPYTLGPFLTEVMNVTPVPLFDGSDRGQTSSRSPSSTTYPPSPPVDGPTAKEETTDAGEDQTEDDLEAESSDSDGKKRKAKDPFEVISQMAVKQRDSPSPKRRKIEDTPNMTIAYICKLHDMHGRLDVQKAKDMGLKPGPEYGLLKAGKAVTTPDGKEIKPEDVLQPTTPGAVFIILECPSEEFVESVVNNETMSRYQADCGDNTATLVLHMCPENVINDARYHGWMQRFGPTTEHLIFNPTCHSVTHAASRRIQAKLNLIHKDVFPLLPVQETDAVQQEIASTEDSPGNVRIHKAESYLRYHLRPHTGWDREFVQSPSNQPFIEEAMALTGFKERLDELGNQLTEHQQRCSTEDSPRYPEVVFLGTGSAMPNKERNVTGILLNLSKSQSMIMDCGEGTFCQLCRFYGDRVDDILANLQNIFVSHLHADHHGGLIQILRQWKRVMVERGEMNKNLILVGPKRMLIWLNNYHASCESFIHQMKFIELGDLSWRSEERTRHEQSLLTRLNLAEYTTVPVPHCFNSHGLVIQHEDGWKLVYSGDSMPSDNLIQAGKDADVLIHEATLEDGLEAEAQKKRHSMISQAIDVGQQMGAKFTLLTHFSQRYPKIPFFDEQLSHRVGMAFDNMRVSLYQLDQLPLCLEALKHVFTTYIQEMQETRDKKAEKETILPLQIALKIGKVVSEETNSDGKETEGQATSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1D2</accession>
    <name>A0A914B1D2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069306.1">
        <property type="nucleotide sequence ID" value="XM_038213378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1D2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213378.1">
        <property type="protein sequence ID" value="XP_038069306.1"/>
        <property type="gene ID" value="LOC119738473"/>
    </dbReference>
    <dbReference type="GeneID" id="119738473"/>
    <dbReference type="OMA" id="REAINCK"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="208" mass="23565" checksum="54D692FFF2167BB8" modified="2023-02-22" version="1">MRFASHAALGMSYLAQHKFVHRDLAARNCMVNSDLLVKIADFGLSRDMHESDYYTSGDAQAKLPIKWMAPESMERRVYNARTDVWSYGVLLWEIFSKGAKPYPGIPNQDVYDFLKRGQRMDAPKNCPPEIYGIMVRCWQDNPKSRCTFVQVANELEELLEGDRDYVAAPSVGVVGKRPIKHREEPGVTDDSYLVPMQQETAFGADGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B229</accession>
    <name>A0A914B229_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070405.1">
        <property type="nucleotide sequence ID" value="XM_038214477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B229"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214477.1">
        <property type="protein sequence ID" value="XP_038070405.1"/>
        <property type="gene ID" value="LOC119739503"/>
    </dbReference>
    <dbReference type="GeneID" id="119739503"/>
    <dbReference type="OMA" id="ANCEKSP"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34373" checksum="B56FD29438227193" modified="2023-02-22" version="1">MANCEKSPSPKEQQVRLMIWTTPRTTSTALTKCLSFVKDSKVFFEPYLTAYFMGPDKSVSPNERGDSYPALKEEFVGWFDASQCTYKWVKEQLEGTHDGKKFILCKDMAYTVSDRFAFLPENYQHLVLIRNPLKVFPSWKILFRQIRRVSMDEYELDKLPPGLFPEGRGYKEINDLIEYLKETRNQEVIIIDADDLLQDPKGILSALFKVIGMPFEERLLSWEAGDAITREWVVAKHCLEVNQVGHMYNTAFDSTCFTKPRPLPDRRSLSPDILRCVDASIPYYNKMHARRLTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B507</accession>
    <name>A0A914B507_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071336.1">
        <property type="nucleotide sequence ID" value="XM_038215408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B507"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215408.1">
        <property type="protein sequence ID" value="XP_038071336.1"/>
        <property type="gene ID" value="LOC119740189"/>
    </dbReference>
    <dbReference type="GeneID" id="119740189"/>
    <dbReference type="OMA" id="AASEWHE"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF85">
        <property type="entry name" value="GALACTOSYLCERAMIDE SULFOTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="51922" checksum="CF43F5C2C8081251" modified="2023-02-22" version="1">MCEVRPNQLIFLFLVGAVVLSCLFERFGLMLRTMTPMHVAQRTPQAKGPTGRRLESVHRRPALASRTVLVRSRSAIPRSQFLNELQGAATLARDHSTCDGSDPQVNLVFVKTHKTGSTTLSHIINRFGYTRGLSFAINKKSVHNGHLGYIPLGKDSPRETFLPPIGVSKYAITKFKYNLMTVHVRYDRAAIDSFMKSPTRYVTILRDPGFQFESAFSHFQFDDAFLTQEKKVYSTATSRLARFLDAASFYRERLKHLNWEGQKGLRWYYAKNNQMYDLGLDHTYHTDQEVVDAYIRKLEAELDLVLITEYYDESLLLLKSMMCWDTDDVLYVAKNMRPPTSADTVPESLRARMRKWNAVDAKLHAHFNRSLWERIERYGPAFQSDLAKFREELESVFQSCVGDLKISSQGRFRYSNYRVRAGSGVNCTLIAESKSSLFSSIWGQQAQRRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B513</accession>
    <name>A0A914B513_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071032.1">
        <property type="nucleotide sequence ID" value="XM_038215104.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071033.1">
        <property type="nucleotide sequence ID" value="XM_038215105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071034.1">
        <property type="nucleotide sequence ID" value="XM_038215106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B513"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215104.1">
        <property type="protein sequence ID" value="XP_038071032.1"/>
        <property type="gene ID" value="LOC119739950"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215105.1">
        <property type="protein sequence ID" value="XP_038071033.1"/>
        <property type="gene ID" value="LOC119739950"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215106.1">
        <property type="protein sequence ID" value="XP_038071034.1"/>
        <property type="gene ID" value="LOC119739950"/>
    </dbReference>
    <dbReference type="GeneID" id="119739950"/>
    <dbReference type="OMA" id="IVAPLWG"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17384">
        <property type="entry name" value="MFS_SLC18A1_2_VAT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000145">
        <property type="entry name" value="Chromaffin granule amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="522" mass="57692" checksum="0C4EB52699722DF7" modified="2023-02-22" version="1">MMDSEKQVSVPVYENFRASLHYRWRDFSAMECIRNLRQSRRLVLFIVFVALLLDNTLMTVVVPILPDYIFAQEHPEYVNGRLMSEYNRSNCTQLPTEHLSSMDTADPMWIDECNVNGTSATMSPEEKLEYRLLLRHANLKVGILFASKAIVQLITNPFVGPLTNRVGYSIPMFTGFVIMFVSTLVFAFGQSYWLLIVARMIQGIGSSCSSVAGMGMLAQRYPGYEERGAAMGIALAGLAFGVLIGPPFGGAMYQFVGKESAFLVLAALALADGFLQLLVLNPGINKETEMEGTSLLTLLRDPYILVAAGAITFGNMGIALLEPSLPLWMLDRMHNPSNWEIGAIFIPSSISYLISTNIFGPLGHKIGRWLSSLLGMVLAGLAILVIPFAKELGHLVVPNFALGFAIGMVDATILPIMGHLVDIRHVSVYGSIYAIADVAFCIGFAVGPSLSAAIVQAVGFTWLLRIVAILSFLYAPLCYFLRDPPRREDKLGILMEERLPVSYTTHKQTDYQTMEEDETQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5V2</accession>
    <name>A0A914B5V2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071195.1">
        <property type="nucleotide sequence ID" value="XM_038215267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5V2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215267.1">
        <property type="protein sequence ID" value="XP_038071195.1"/>
        <property type="gene ID" value="LOC119740065"/>
    </dbReference>
    <dbReference type="GeneID" id="119740065"/>
    <dbReference type="OMA" id="SASMACY"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="409" mass="43916" checksum="BE475A0DFE2B6B3A" modified="2023-02-22" version="1">MRQANQPGPGVMFQPVSQPLMASSGPVGFQPNSPNKKVPALMGLSIVHVALGCLSTILGIVAIILKCNYSYVGWGLWSGVSFFGVTGILGLIGATRKNNNGIVIAFMVMSIISAAVAFQLLVAAAMAAASERYSTCHPGTSYRSSGSCYTQRPGRVAVDSLLAITGLAEMVIAVVSASLSCYGMCSCCRSYTPVTVQYVPQQLVPMMPVQAQQQQQQHLQQQQQQQQQQQQQQLQQQQLQQQQEQQQLQQQQEQQQLQQQQQQQLQQQQPQQAGHGFIAVNAQQQQGPSQQQPMQAPTAMQGSPIGSQYVTDYRASPTQQMANPPQQIAYVPQPVGPATQMVIAPQPVSMAPQQVVVSVPSQTAPTGPVEAGGPTAETPDAYANQAGVTNSGGSEHFHHDDKEGLLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B776</accession>
    <name>A0A914B776_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071998.1">
        <property type="nucleotide sequence ID" value="XM_038216070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B776"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216070.1">
        <property type="protein sequence ID" value="XP_038071998.1"/>
        <property type="gene ID" value="LOC119740692"/>
    </dbReference>
    <dbReference type="GeneID" id="119740692"/>
    <dbReference type="OMA" id="GECECEW"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037825049" description="C-type lectin domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="19663" checksum="DCC1955CB6CBDF03" modified="2023-02-22" version="1">MSCGNVDILISLAILNANLSFSATCSQSQGLCTAPWKKWGGSCYLITQKHLTNDDAREACRRLGAKMTAPRSDQENDFLASLAQGSKIWVACTDRRQEGECECEWSQDGEGIYTNWREGEPNNYGGREDCVFLWPSDKKWNDVRCEIEIWAVCKRQLGSCFSTNNEGRLEVDSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7E4</accession>
    <name>A0A914B7E4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071889.1">
        <property type="nucleotide sequence ID" value="XM_038215961.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215961.1">
        <property type="protein sequence ID" value="XP_038071889.1"/>
        <property type="gene ID" value="LOC119740603"/>
    </dbReference>
    <dbReference type="GeneID" id="119740603"/>
    <dbReference type="OMA" id="NVGECSF"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037390552" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1627"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="579"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="831"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="1246"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1682" mass="174247" checksum="A1BC9FCE67F2DCE3" modified="2023-02-22" version="1">MGLKRGLCAMMLLALCIMSVQGTAPTFVNDPCADEIITQPDEGMNDATVYWAIPLAKVGDTPAAVTCDRMPGEKYAGGNNDVTCTAKDVDTPADMTTCTFQVRVFPTFERACPADFPSATGDGVTFDEPLTNVDTDGTTKPTVTCDNPVTFPAGPTTVTCEATGTESRKVSCSFEVTIGTLPTFTDQGSCADSKIDTAPDAGENTATVTWTEPTASAGASITCDHSTPAVFKGGDTTVTCEAADNTESRLFISCSFDVKVYPTFETGCPDNMVVANGASPTFTTPAVNADSTGAAVTASCSPPSGGPGFTDDLANDVTCTAQDGTLTSQKATCTFKVTLGTTPVFTAEGSCAAPGTIDVLPDTGKMTATGITWVTPTAGVDVNCIPDPDTATFVGGETDVTCTIADASTPTLINTCTFKVRVFPQFAENSCGEDVIRSPDPNDYKATYAWINSAIKMDGAAATVACQQASGSKFGGGENDVTCTATQAANEVSTCKFKVTVWPKLDGAVADMTQAPDAGSNKVASVTWTPPSVTDPGGATVTVTCTPELGTSFVGGSTPVECYGEDPTSKLRAVNQFSVNIWPNMPDSQLVLDIKRAPDLGKNVATNVVWDTPTATDSDGDPLTATCTKASGSDFSGGAHDVECVATDPLGATFKATSQFKVEVWPNMPDSELVQDINRAPDQGKNVATNVEWVAPAVTGSNGDPVPVTCTPASGLEFIGGAHDVSCVATDPLGAPYKATNQFKVKVFPTFATVCVDFPPVAPETGTTTVVEYVKPIGAPDSTTTNAVVTCVPETGTAFLNDKETVVTCFAVDSDTEKFPTKATCSLKVTVGTAPTFVANKGCLAEKMTGPTAGKNVAEGVTWTTPEATQSDGEAATVTCEPPSGSDFNGGSTPVTCTAVDTRMPNLKTECSFNVYVFPTFDGTCDDQFATPTSGNTNVNYNVPVGALDSTNTRAAVTCNPASGSSFPDNVATEVKCEATDSDTSYEEKATCSFNVLVSAAPTFDNDPACPADEAVSPGATGFNKAVATWTDPPARQGDGTATALVTCDPPRGSTFGAGDTTVTCTAEDPRSSSLTTTCDFKVRVYPTFASGCEDIEVDKGATGTETTVDYVPPVGGTDSLGTNLVGISCDPNTGDAFPNDQATEVTCNATDVAPDTFPDATCTFKVKVGTAPTFNKGCPSNIVVAPDASGEAVVTWEKVTGGSPATVQCDHKSGDTFNETETLVICTATDAGSERTSQCTFKVILDSVAPVILCPPTPANADAVTGTNKAPVEWTDPTVGYDDGDQTRPVNVTCIPKSGSSFVYGKTAVYCSAIDFVGNVGECSFDVTVTGKACDPVCAGESDCMLDDVGAASCVCRDGYSSATNDGADCANVDECAAATSPCHENADCTDLTPSFTCACKEDFYGDGIFSCSPYQDEYPDIAVPVDKVFQVELSIADASGADCDPVTDKESDACVALVNTFKLFVTPSYSGLSNSFKEVVVDQSQIRKGSVIVPHTVSYDYGTATTEIRALQPQQFFADTVKKQVEAGRIGSLEMVPDFESVKDTTNFCTEEIKNAMQCNNKLSVYEDKTDDGCQLKCSSRCSTDAVYCNGGTCTHDNAAGEICSSCPDGKEGALCEEDSINIPLIVGLSVGLGGGGLLIIIGLIVYFMCCRNKEGKATVTAAGDEEGGHSNNALALDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7T8</accession>
    <name>A0A914B7T8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shootin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071492.1">
        <property type="nucleotide sequence ID" value="XM_038215564.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215564.1">
        <property type="protein sequence ID" value="XP_038071492.1"/>
        <property type="gene ID" value="LOC119740295"/>
    </dbReference>
    <dbReference type="GeneID" id="119740295"/>
    <dbReference type="OMA" id="HETMKMA"/>
    <dbReference type="OrthoDB" id="10072132at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF5">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="74773" checksum="44F97328D38B56AD" modified="2023-02-22" version="1">MVDPAGSLSFISIAFSVIGAHNPLHHDNMVKENKDIKRKSAAFLSRAGEDLVRQFELSLDEGDEEETENGADPHLVKELTARIEDLKDQLIASKRDLEQVLLERDEARDEVQGISDQGKQFAEQLLLERQGHEATKASMEADRVAHETMKMALEEKIQTIAQFRRVSTVVFQELFEVKGKYEEEAMLREKAENFAAQMYKERQAADAHKRQSMLMLNEAIGPDEKLEEVLREVEQLTKTLADEKQKHEKEVAQMQANLREAGDMDHLDSLETKLSIAREENEALEKKVNEQLPNIRKLQDKIAEQDLTVKKLMAELDKAMLKPVAPXPPPPPPPPPVPQSPLEVLRKIIGVRRANKGGGSASTQTDGGGDKAGKGDPHQKQYEATIDEMMNRIKSGRVKLKPVQTEEKTLLTRKGPGSIRNMSPAMSQLNGMLTVLKKRGHHGDATAGSDGSAQGAPSPELAAIMQRRRKKTEEIVLDKPAVGETQDGAQSDGHVGNPPERQNGTTPKSKRKPPVPVPRSSSTTSMYEQEPLHSKLTKSTSVDSGMTDGNTASKEDKTDTASIKTCPEMSLAEEGAYSEIAPDADDKKSDMSLSGSYPSFKGSSEASSEFSEKDSEVSSNKGSGELEDILLHANPAYESAESIQFSEEGEGHVGEEDAYETLRIGAANSTHNGNSTYSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7Y8</accession>
    <name>A0A914B7Y8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072288.1">
        <property type="nucleotide sequence ID" value="XM_038216360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7Y8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216360.1">
        <property type="protein sequence ID" value="XP_038072288.1"/>
        <property type="gene ID" value="LOC119740889"/>
    </dbReference>
    <dbReference type="GeneID" id="119740889"/>
    <dbReference type="OMA" id="WLMHEVP"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="182" mass="20421" checksum="7C95E15697213E13" modified="2023-02-22" version="1">MAATGRYRRISDVDRNRLIDAFEADDADYLQVADTLGIKHSTARSIVGVYLRDGRRNKLPKGGPINQKVDDDMRDALQGYLDDNPLLTLRQLNTQLRADLPDKPFVTTSTIARTLDGMLITLKLAEDVPEQRNEPRILDARVIFGNWFLQVGVLGHTVYIDETGCSGEVGQNIIRDCDESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8K1</accession>
    <name>A0A914B8K1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072504.1">
        <property type="nucleotide sequence ID" value="XM_038216576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072505.1">
        <property type="nucleotide sequence ID" value="XM_038216577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072507.1">
        <property type="nucleotide sequence ID" value="XM_038216579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072508.1">
        <property type="nucleotide sequence ID" value="XM_038216580.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072509.1">
        <property type="nucleotide sequence ID" value="XM_038216581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072510.1">
        <property type="nucleotide sequence ID" value="XM_038216582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8K1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216576.1">
        <property type="protein sequence ID" value="XP_038072504.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216577.1">
        <property type="protein sequence ID" value="XP_038072505.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216579.1">
        <property type="protein sequence ID" value="XP_038072507.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216580.1">
        <property type="protein sequence ID" value="XP_038072508.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216581.1">
        <property type="protein sequence ID" value="XP_038072509.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216582.1">
        <property type="protein sequence ID" value="XP_038072510.1"/>
        <property type="gene ID" value="LOC119741016"/>
    </dbReference>
    <dbReference type="GeneID" id="119741016"/>
    <dbReference type="OMA" id="WTNNQEA"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="261" mass="29033" checksum="ED89126106D7A805" modified="2023-02-22" version="1">MSFPANGDYQESGRYNQHGIIMRNIGKLTFRPEDVVLDVGCGAGEETKALASKVSSVTGVDTSEEKVAFARANNSEPSVTYGLGDAQTIGDNPDYLGRFDKAVSFFVLHWCPDPAKALRSILACLKPGGEGLLMVGNRTTFPPDVRAFLGSHARWGEYVKGFKGSQYFWKRSISEAEELMATCGWTKVQCEIQHRLPTTELQTKLFFKTAIGITARIPESDQEAYLEDLWQWALSRYQVETQDGHVCIPIEYLVIHACKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9R6</accession>
    <name>A0A914B9R6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072187.1">
        <property type="nucleotide sequence ID" value="XM_038216259.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216259.1">
        <property type="protein sequence ID" value="XP_038072187.1"/>
        <property type="gene ID" value="LOC119740822"/>
    </dbReference>
    <dbReference type="GeneID" id="119740822"/>
    <dbReference type="OMA" id="MLELCEM"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF1">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="564"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="645"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="727"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="919"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145323" checksum="16DBB7F0A1E60C16" modified="2023-02-22" version="1">MPSTKEVAELIKKDPTAVDAYMPLVLEAIRDDQNHANWCDDLKLAISRQVFEEVKSQSNKHEQHMLELCEMCLEKRSATKWYYLAVDMFEEKRIINWKQHVALAEKLIKTFEVPVALVRSKDEVSGLSKGCPPSDTGIGVALMRCIHAMMAGLDRDKILKKVSKCMVEVLVKLSKMPNELQIIAGHAFCSSSRQPLSWDGTENMLPELYTNLYEWMTSGNVDLKSKRNDKTQFIDSIISSSLKGARSPSKYAKEIYKIHQYVLTQELDGDPYSGYGLLAITINSGFVEKNYGNQRLIRDFVPGVVKMLKCDNKQLMMNASSCITCFQQQGDLLAPYADDVMEAFLDEKSDLLGHCLKPLYGASPEKILSRFDQLAEAMEDMNPTNKTYIYMMWDDVAKDNAKLLVPHLDLMMDDVTNARFCHQVVIILGTMSVKFPGKFVDKIDKLVKVAKQTPYTIHAVSKIVASVGQINEKQAERCMKILVDKLKTIEDMWLSVIMMDMKRIGLKHVEVLKKYRADIEPFMKSQAMRVPDMVQSLIDFMDGRSLEALADDVEDVKEDVQNLDDRVTETEENVDRLDKTVTEQGQEIDNVKNEVTEQGQRLGDLEEVVDDTIVRVDEIDRKTITNAPKWSRDIANLLNPEHEHDWRFLAIRLGFTGEDVRNWALSPDPTMAILAEWYTIHKSSEATFAILTALQDMGRDDAATIVEEALQAADKVVPKAVPDISEKPPRVFISYQWDHQPEVKVIKEHLEKAGFNCWLDIGQMGGGDSLFAKINEGMRAAKVVLCMCTEKYSKSENCNKEVNLANLLNKPIIPVLIEKIDWPPSGSMSMLFAQLLYIQFFTDKEYVRGEKFWEDAKFAELLGQISYHVAPDEEMITDEYRNWVPQIDDLPKVVKTANEKKSTDDNTKSEKVTDQAQEIIPQVFISYQWDKQTEIKTLYSRLTSLGFSCWLDIMQMGGGDPLYSKIDKGIRNAKVVVSIVTPKYALSANCRREVSLTDALRKPIIPLLMQRMTWPPEGPMSMPFAQLLYIDCTGESTQKEFRDAKFDELVQKLKEHATVEDTVVQSAPPSDTEKPEIEEAKQVEEKSQSPPAAENIITPESEEKEDPAKQNQPPKEEAKEDQKLEPISTEDPAKLSGSTVPQQNQPPNEDADEDQKLEPISTEDPAKFAGSTVPQQTQPPKEDAEEDKKLQPMSTEDPAKFSGSTVPQQTQPPKEDVEEVQKLEPVSTEDPAKFAGSTVPEVRPQSVMGPKHAEVIQPERSVSAPKERARPDSPKKKKKSSVCAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB43</accession>
    <name>A0A914BB43_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073060.1">
        <property type="nucleotide sequence ID" value="XM_038217132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217132.1">
        <property type="protein sequence ID" value="XP_038073060.1"/>
        <property type="gene ID" value="LOC119741381"/>
    </dbReference>
    <dbReference type="GeneID" id="119741381"/>
    <dbReference type="OMA" id="QYACPDG"/>
    <dbReference type="OrthoDB" id="10046193at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF44">
        <property type="entry name" value="LDL RECEPTOR RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038022539" evidence="10">
        <location>
            <begin position="31"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="331"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="395"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="535"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="688" mass="74510" checksum="2B015B5C4CD13744" modified="2023-02-22" version="1">MDGTGGSRKRWCLQHFLLSVLLTTFRTAHAGDFALIADLNNGTIYAGSMGRSLVDLAPLPLSGIVRPVTVDFDPQERMIYWSDLRSQPSPKISRANLDGSNQMTIAENLRLPDGLALDVEARILYWTDGVLGHVGRASMNGTGNKEIIVENLDQPRTIVTDHSHGHIYWTDWGSSPRIERADLDGGNRTSVVDSDLHWPNGVTIDADYLYWCDAFLNKIERSDLSGQNRELVIDLNPYGDLHPYDLDVYRGDVYWTDWKVNTLIRVSLNGRGEGNFGPSTFQQPGGIHIEEEPDHCDSSPCDNGAPCEDVIGGFLCQCPPGLQGTTCSDATSCVLPPDPSDVLMVVSGQQAVYLPGDSVQYACPDGYQLSGSTTRICLSDLTWSGQQPTCSLTVVGCAPPTPDPSDVLMVVSGGQAVYHPGDSVQYACPDGYQLSGSATRICLSDFTWAGEAPVCQDELEPTPDVSGCTPPTPGPSDVLMVVSDQRAVYLPGDSVQYACPDGYQLSGSATRICRSDFTWAGEAPQCMEDDPATVSGCTPPTPDPSDVLMVVSDQRTVYQLGDSVQYACPDGYQLSGSATRRCRSDFTWTGQAPQCKKEDPISGKSTGAIPVAIIAGGSGGAVLFLVAVAIICVVAITVKRRRRRRFGGRVPISDIADRTCKEVFPKEYSTYVHYEKHIAEPLYSETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBG8</accession>
    <name>A0A914BBG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038072777.1">
        <property type="nucleotide sequence ID" value="XM_038216849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216849.1">
        <property type="protein sequence ID" value="XP_038072777.1"/>
        <property type="gene ID" value="LOC119741152"/>
    </dbReference>
    <dbReference type="GeneID" id="119741152"/>
    <dbReference type="OMA" id="MRLWQKL"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23964">
        <property type="entry name" value="GT29_ST6GALNAC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF2">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="230"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="52005" checksum="68CBB6632143308C" modified="2023-02-22" version="1">MHAMAIPTTRVGKGLLTLFLVTICSLAVRYYVAHLPSLTVQAIYNNGSGQSSSTQRTNVLQRILHKALDFSPKSSEESALNENRTLSRIERFSQSQPPNSSYGETFLNSIRQRARLKETHWYSDEKEFVRDSQFLNYLRCPTTVRKKMLQEPLSNQKFLPEVPILMYDDHFSHNEYQRLSKFKGIYGWEDMDEKELSEALKSLHTPNNRYMFDDRFVEGFIPKDVGCTRCAVIGNGGMMNGSKKGKEIDAHDYVFRVNVALTKGYEEDLGTKTSFYCFTMVTLSNSLRGGGRLGFKEPPYEKGIRYVFFADNDWTYSYLNAVLNNRPAPRSADKYRRTPPNFVKNLQAEDVKLVHPDFQRYLKWSWVNSTAQHKTVHRPTTGAIMLLLALHTCDEVNVYGFGGSYSKFSEHYYDKKFTKHIFFANHDNNAENALWKRLHDLGIINLYTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBJ3</accession>
    <name>A0A914BBJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072801.1">
        <property type="nucleotide sequence ID" value="XM_038216873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072802.1">
        <property type="nucleotide sequence ID" value="XM_038216874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216873.1">
        <property type="protein sequence ID" value="XP_038072801.1"/>
        <property type="gene ID" value="LOC119741167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216874.1">
        <property type="protein sequence ID" value="XP_038072802.1"/>
        <property type="gene ID" value="LOC119741167"/>
    </dbReference>
    <dbReference type="GeneID" id="119741167"/>
    <dbReference type="OMA" id="KHCVDYL"/>
    <dbReference type="OrthoDB" id="636773at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18487">
        <property type="entry name" value="BACK_BTBD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18281">
        <property type="entry name" value="BTB_POZ_BTBD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000037">
        <property type="entry name" value="BTB (POZ) domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.820:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="59174" checksum="0AFACB7548DC96C9" modified="2023-02-22" version="1">MAGAGAHRNLNGRLNGQFNGQLNGQVNGQLNGIPQQQQQQQLQQQQQQQQQQQQRQQPQQQPQQQQQQLPHLQQWALPLAPLQPTQPPGIPTVRPRGEAVPYNWQSSKTSVKERFAFMFNNEILSDVHFLVGKGINTQRIPAHKFVLSVGSAVFDAMFNGGMATTSNEVELPDVEPAAFLALLRFLYSDEVQIGPESVMTTLYTAKKYAVPALESACVEFLKKNLSADNAFMLLTQARLFDEPQLANLCLETIDKNTAEALQAEGFTDIDLDTLINVLERDTLGTRESNLFNAVSRWAEHEAVRQQYPATPENKRKVLGNALKLIRFPLMTVEEFASGPAQSGILTDREVVSLFLHFTVNPKPSTEFPSNPRCCLIGKEQTVSRFVQAESRWGYSGTSDRIRFQVNRHIFVVGFGLYGSIQGPADYTVNIQILHGDTEDVLGQNDTGFSCDGSETTYRVMFKEPIEIQPSVSYIASATLKGPDSHYGTKGMRKVVHESVSSGKVVFQFTYASGNNNGTSVEDGQIPELIFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDD4</accession>
    <name>A0A914BDD4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038073442.1">
        <property type="nucleotide sequence ID" value="XM_038217514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDD4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217514.1">
        <property type="protein sequence ID" value="XP_038073442.1"/>
        <property type="gene ID" value="LOC119741674"/>
    </dbReference>
    <dbReference type="GeneID" id="119741674"/>
    <dbReference type="OMA" id="STHAITF"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037915626" description="Carbohydrate sulfotransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="46236" checksum="D84EA5F7E00F6385" modified="2023-02-22" version="1">MSRAGRCMLCCVVVVAVTVLASIQRLGLPASIIREPISMNKLLAKRGKDQSQEHKGTRVSYKQDESCNNRTCLWEKQQLYRKGLAWDMCSALHAHGADTHHHPPRYRLDESRNKTRLASMFNFFLVIDSLKLIYCFIPKVGSTSWERLFLVMSGIYDSMEEIGQSETHIITWRTFRTLASYTVAEAEKLLATYRKFVVVRNPYERVLSAYQDKFQEDYPASRVTRKQYSEKIIRMTGGSPENVQRLLQSQRRKDGTLNVTFSQFVRFLSHLGGPKTRQYMNDHWKPMNLICHPCLVDYDWIGHYDSLRTDADFILTAVGADPKFRFPNFTTNPTGSSNGDTLLRYYSTLTTAEIEDLYKYYELDFSLFGFDIPPSIRSLLNNRGRANDYTTIDQTRLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDI5</accession>
    <name>A0A914BDI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Arginine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074292.1">
        <property type="nucleotide sequence ID" value="XM_038218364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074293.1">
        <property type="nucleotide sequence ID" value="XM_038218365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218364.1">
        <property type="protein sequence ID" value="XP_038074292.1"/>
        <property type="gene ID" value="LOC119742442"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218365.1">
        <property type="protein sequence ID" value="XP_038074293.1"/>
        <property type="gene ID" value="LOC119742442"/>
    </dbReference>
    <dbReference type="GeneID" id="119742442"/>
    <dbReference type="OMA" id="ERCKAIM"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000002">
        <property type="entry name" value="Creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000005">
        <property type="entry name" value="Glycocyamine kinase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF63">
        <property type="entry name" value="CREATINE KINASE M-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="115"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44844" checksum="A7E2EEC8633A0F0F" modified="2023-02-22" version="1">MASLYQQKIPAGEDFPNFEGHNSLLSKHLTKDLYVKLRDVTTESGFTLDRVIQNGVDNADFHLGVLAGDEQTYEVFKEVLDPIIQEYHNGFKPTDNHVTDMTISKLEGGKLNEKYVISSRIRTGRNIRGYALSPFICRAERRQVEKIAQSALGLFKDKLEGKYYSLQTLGEADKQQLIDDHFLFERPISRHFTSGGMARDFPDGRGIWHTADKKFLVWVNEEDQLRIISMRQGGDMKATFELFCEGLNAFEKNMAAEGKVFMKSDHLGFILTCPSNLGTGVRCSVHARFPLLADDKRYDLDKICKALRLQKRGTSGEFTDAVGGVYDISNLDRLGTTEVQQVQCVIDGVNKLSDMEELLEKGEKIDHLLPMGVTAMENTNTNNSSRSPKAKKTSVCVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEW0</accession>
    <name>A0A914BEW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BBSome complex member BBS1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with the C-terminus of RAB3IP. Interacts with CCDC28B and ALDOB. Interacts with PKD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073957.1">
        <property type="nucleotide sequence ID" value="XM_038218029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218029.1">
        <property type="protein sequence ID" value="XP_038073957.1"/>
        <property type="gene ID" value="LOC119742021"/>
    </dbReference>
    <dbReference type="GeneID" id="119742021"/>
    <dbReference type="CTD" id="582"/>
    <dbReference type="OMA" id="HADRRHY"/>
    <dbReference type="OrthoDB" id="10259809at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002248">
        <property type="entry name" value="Bardet-Biedl syndrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="19">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="20">
        <location>
            <begin position="500"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="607" mass="68106" checksum="371503BF21AE1EF0" modified="2023-02-22" version="1">MKPSTKMTTDVDRNSQMASEQANSDISTHEGNSKWLDAHFDPVASLYTFSSCMAFSDINGDGENKLVIADLGTGSANMKLKVYKGTSLMSENAIIELPTGVSTFFMDTNEPRVPAIAVASGPYLYVYKNLRPYFKFTLPPLDVNPVEQDLWNQAKEDKIDVTVLREMLDSIRREGNEGALTVRSLRYLMLPDKEQMESFANLHKQTTIKRQTVITCMDTLKKSSADEDAISCIVAGTESKEVYILDPEAFTILAKMSLPSVPVFMSVSGLYDVEFRIIISCRDGNIYALKRGMKIAKHCVELNSQPVGLERVGKNIVVGCMDQTLQCYTMKGKKLWTVYLPSSITTMSIMDHRQKGFKAVMVALDNCEVHFYREKYLINTIKCGDVITGLQYGRFGREDCTLVLTTRHGGLLIKILKRSAMFEDKDTVRGPPPAQTQKLNVPKKTKVFVDQTMRERENGIAMHRMFQHDLYRLRLNTARSFVKSLDNRLTPISSNPAEPLKLSAQIQGIGPTFKLTVNLQNTSINNPSMQLLITFLYDEKLYSLQKTMIEVPMLVPGLNYSFETLVECLSDKGISDVIKVFVLREGQSIPIITAVISMPVSETMVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF53</accession>
    <name>A0A914BF53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isthmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074878.1">
        <property type="nucleotide sequence ID" value="XM_038218950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218950.1">
        <property type="protein sequence ID" value="XP_038074878.1"/>
        <property type="gene ID" value="LOC119742777"/>
    </dbReference>
    <dbReference type="GeneID" id="119742777"/>
    <dbReference type="OMA" id="MPWIICK"/>
    <dbReference type="OrthoDB" id="9930623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051867">
        <property type="entry name" value="Angio_Inhib/Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239:SF29">
        <property type="entry name" value="AMOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10239">
        <property type="entry name" value="ISTHMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AMOP" evidence="7">
        <location>
            <begin position="446"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="619" mass="69540" checksum="9445215FBBF9B5F1" modified="2023-02-22" version="1">MGKLTSWFSFLRQSPRIISMSSVEYIITRVRSTQLRVIFCLLTLFMCISFAEGLDISSGRVVSSRSDTGTGKTSGRVAELVSREDQEKRTGIHKLNKTGSLQDILADEGLPKTHKEGAVPNRRYGVFSGKRSSSRLRTVQTRTAKPKLLAESDGDGMKTWEQLWNEQALPPSLPTSGEIDTDDYYTYDYFEDAEDDDDDEEDEEDEDSKGLSIDRSKKDTSSAESKSHSLDRLAELVTGANPQMGPVNLGTPNPDIEITIEILNGEDAKHEDVVISMDLRDDIVGTPATPDSRRHDGEGAPRPEGETDHDNVLIPPTSKIDEEPSQSEEEPDLGGPDDDDQDSYYSFEFVTLRRLPDPDAINFEPDDPEETIGTWTEWSSCSASCGGGRSERSRSCGFSCMATESKDCNQQACPRGGKSESRPDAAVERPQPPSVDSEYLETVLDPNNFDTDSCEEWMGCRSETLLSYLSRLQDLPNCPCFYPTNLQRNNAIWDRQKRQMFRWMDTSGEDARLDVYKPTASYCIISLLSPHSTSLAAQQCCYDENLRLITRGSGAGTPQLISAEISPELHYKIDIMPWIICKGDWTKYNKVRHPNNMRECRELPDQAEFYRLFQEAKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFE2</accession>
    <name>A0A914BFE2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074804.1">
        <property type="nucleotide sequence ID" value="XM_038218876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218876.1">
        <property type="protein sequence ID" value="XP_038074804.1"/>
        <property type="gene ID" value="LOC119742708"/>
    </dbReference>
    <dbReference type="GeneID" id="119742708"/>
    <dbReference type="OMA" id="TIVECIC"/>
    <dbReference type="OrthoDB" id="10072016at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="430" mass="48406" checksum="0FC0DFF714085297" modified="2023-02-22" version="1">MLAAVHSLEVKRKDSYRLTAKKFNLPESTLRRWATNGVPAGKPQGGRTTFFKEYEEKKLAEHISYVGQMGYSYLGSQIREIAGEMARILCSEDQERKCRFTDFIPGRNWYYGFLTRWKNIIRPRRPSRLDHLRAEMSRRSILEAYFGKLLEVLEKYNLRDCPAQIYNVDETGITRDHKPPKSLGPSQGAFNAVSCGRGPIHTIIACGNAMGNRLTPYIIFKGARVRQEWTEGTLSGTGYNATKTGWSNSATFLQWFKGHFLPQVGSVRPLLLLYDGHSTHISVQIIEEARLEGVHLFVTPPHTSHILQPLDVGCFAPFKATYNRAVHNWLHKYKNTGCILVEEDIASLACKAYMMGISSDSLVSSFRCTGICPFNPDVVLSKLPEQPERGSSSIDGPYREVSIISRSVRQATKSNKKCPNADGGRRIPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGC4</accession>
    <name>A0A914BGC4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074487.1">
        <property type="nucleotide sequence ID" value="XM_038218559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218559.1">
        <property type="protein sequence ID" value="XP_038074487.1"/>
        <property type="gene ID" value="LOC119742542"/>
    </dbReference>
    <dbReference type="GeneID" id="119742542"/>
    <dbReference type="OMA" id="RLSIVWY"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036673489" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134455" checksum="8919FD0FA03336BB" modified="2023-02-22" version="1">MKTITQRATVACLCCLLYVGTLHLAEADQARETSKQQSLQEQQKQEQQKQQQQHQQQQAVHRTEESMPKVSQNVPRDVGAGSPSEGIEPNIANSNQEILTQAASNDRTGGQSQQKQQQQHQPTKEHVHQSHPTGLQSPQQPPVHQQASQTQQQQLQQPPLSVQQEFANQKVQNMHQSKTTGSHIPQDQQSSQTQQQQQSHSQAPKQQPNVDSRPTPQQASQSDQVNGKMQMSSAGNQGTGQPSNPSQQVRPDVGSSTPNQQSNTNAQQHASGQQTSGGSQSTERLLDPEKLEQLQEETERRLQLLQQKHKQQQEILNQQKLQHQQAQQQQQQQTPQQPLQHQNPQAVAPEQQQQHLQTSQHTVDQQHAQQHPHQQPAQHLHQHQPQVPQQQSLQQQQQAANQQQPLNSQQQPPAQQKLPSQQQNLQYQQQEKPVLNQQHVQQQQPAQNQQPLQQNQQLSNQQIHHQQQVQPQQQTLQQQTQPPLTQQQQQQQQQQPDTKPPKIPEPPKTMQHQQAQHQQQSPTQQQQHQQQQPASQQQNTAASGSSPKSSASKTPGKEADDSKDLADEFAPIPLAVPPLQQPKIEDDETLFGKRPQDPKEAEVWEKANKMYKDSLPLINGSKEMITRGYGLLRDAAYLNQSKAQELVSYSYLVGNHLPMNRSGAEDIFLRLAEKGIPKGQTGLGFLFANGISFNSSQAKALVFYTFAALGGDPHAQMILGYRYWSGIGVTQHCETALTYYRKVANTVADQVSHSGGSLVQRIRLYDEDESTGSHGSVLDEDLIQYYQFLADKGDTQAQVGLGQLHYQGGRGVHQNHMRAFEYFTQAAEAGDPTAQAFLGKMYSEGSRVVKQNNKTAFQYFKKAADQNNPVGQSGLGLMYMYGHGTNQDYTKAFQYFQAAADQGWVDGQLQLGTMYYSGLGVRRDYKMAVKYFNLASQSGHILGFYNLAQMHATGTGVMRSCHTAVELFKNVAERGKWSEMLMEAHDSYKDHDVHSALMQYSFAAELGYEVAQSNVAFILDQGDTSLFSVNETYQRALLHWQRAAAQGYTNARVKLGDYHYYGYGTDVDYETAALHYRLAFEQQHNAQAMFNLGYMHEQGLGMKKDIHLAKRFYDMAAETSADAYIPVMIALSKLGILYTWQYLQEFEYAEQWEQLDMESRFGPHWDMYLVTILLGLNVILGLYVLARRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGS3</accession>
    <name>A0A914BGS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075289.1">
        <property type="nucleotide sequence ID" value="XM_038219361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219361.1">
        <property type="protein sequence ID" value="XP_038075289.1"/>
        <property type="gene ID" value="LOC119743039"/>
    </dbReference>
    <dbReference type="GeneID" id="119743039"/>
    <dbReference type="OMA" id="TERCHEL"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22222">
        <property type="entry name" value="HkD_Hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000024">
        <property type="entry name" value="Hook homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF39">
        <property type="entry name" value="PROTEIN HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="170"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="726" mass="84476" checksum="54A3137F97997F81" modified="2023-02-22" version="1">MTNHELCESLLTWVQTFNLDNSPETVAELTDGVALSQILCQIAPTFFNTGWYSRIRREVGDSWRIRVSNLKKVLEGILDFYNDVLGQQIRDFKLPDVSKIAERHDLEELGRLLQLVLGCAVNCEHKEEYINVIMGMEESVQHAVMNAIQELMSKEMPSNEPPPEAYAEIERQLKRTMEDLQHSLMDKEEVMQRCHELDIQVATLTEERNTLHAENEQLHERLDLGDSVDDPSTPAGRRHQHLQQTVEEYQEENFRLENIRDDLQIRIDMLEREVLEISQKNEKLTSLAEEARALKDEMDVLRHTSDKVSKYESTIETYKKKLEDLSDLKRQVKLLEDKNTMYMQNSMELEEELKKASALKSQLENYKRQVHELHAKVSEETRRADKAEFEGKRHLERVTQFQTEVDRLRTERDSLKETNEELTCNQLAGNISMGMSPAGSPLSAGFADMMPSEIREKIIRLQHENKMLKLKQGETTDEKTQLLQSLLDDSNARRSELESESRISNQRILSLEAEMEELKQQQREEGVSSSVVGESTQSKSKEVNKQKNQDLRLKLNEHKEKLRESDTELQRNRTYIDELEPKYISSSEKVSNLQDMLMKKEDDMRAMEDRYKKYLEKAKSVIRTLDPKQSPASSNELQLLKAQLHEKQKIIEHLEHEREKSKVMRDSEEKLIVSAWYNMGMHMHRKAAEDRLANSNTGQSFLARQRQASNRRSQAIISGHSSNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHS2</accession>
    <name>A0A914BHS2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075644.1">
        <property type="nucleotide sequence ID" value="XM_038219716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219716.1">
        <property type="protein sequence ID" value="XP_038075644.1"/>
        <property type="gene ID" value="LOC119743312"/>
    </dbReference>
    <dbReference type="GeneID" id="119743312"/>
    <dbReference type="OMA" id="MMACISS"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="573" mass="64138" checksum="C9FE252E7633CCC4" modified="2023-02-22" version="1">MHYEDILNHIGPFGKYQKLLVFALFLVFIPPPFHFIGQVFLAANTDHWCAVPASQMINCSQLQLAECQEEQRSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNMSFNSTDVISCDAGWEFDHSRYKSTINEDFSLVCDRQDLPAYAQSVWFAGLLVGSLVWGYVGDWIGRRNTFILTVILVTISSTVTSFVPNFTAYAAMRFFTAAGTYGEYLMIYVLVSEIVGPKNRVGATTVLFLAFAVGYMILSLLAFLLREWRHLQLAISLPFVLTFLVIIVFPESPRWLITKGRYKEATKIIEKIAKVNGIEAPEDLLDKLSEESKEDKKQSSRIPVTQLDLIRTPNLRKKTLILWVDWFVVNMVYYGLSLSTSALGVDDYLAAFVSGAIEIPSYLFCWYMMDRFGRRITLVAFYIFGGVFCLITIFIPLGAARAAVALLGKFAISAAFGHIYIYSLEIYPTIIRSIGMGTSSMVARVSGILSPIILILGKYWEPLPLCVFGGSAIIAGVLSLMLPETMGYSLPDTIQDGENFGKGRSFQLCVKGNDDGENESPTQAPIDYLPLSTMDQTPKQPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BII1</accession>
    <name>A0A914BII1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075656.1">
        <property type="nucleotide sequence ID" value="XM_038219728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BII1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219728.1">
        <property type="protein sequence ID" value="XP_038075656.1"/>
        <property type="gene ID" value="LOC119743325"/>
    </dbReference>
    <dbReference type="GeneID" id="119743325"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="573" mass="63739" checksum="42338F8CF981D0D4" modified="2023-02-22" version="1">MHYEDILNHIGPFGKYQKLILLACVLIKIPTAFHSIGQVFLAANTDHWCAVPASQMINCSQLRLAECQEEQKSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNMSLNSTDVISCDAGWKFDHSRYKSTINEDFSLVCDRQDLPAYAQSVWFAGLLVGSLVWGSVGDWIGRRKTFILTVILVTISSTVTSFVPNFTAYAVMRFFTAACAYGLNLMIYVLASEIVGPKSRVGATTVLFLAFAVGYMILSLLAFILKAWRHLQLAISLPFVLTFLAIIVFPESPRWLITKGRYKEATKIIEKIAKVNGTEAPEDLLDKLSEDSKEDKKQPSRIPVTQLALIRTPNLRKKTLILWVDWFVANMVYYGLSLSTSALGVDDYLAAFVSGAIEIPSYLFCWYMMDRFGRRITLVAFYIFGGVFCLITIFIPLGAARAAVAMFGKFAITAAFGHIYIYSLEIYPKIIRSIGMGTSSMMARVSGILCPIILNLGKYWKPLPLCVFGGSAIIAGVLSLMLPETMGYSLPDTIQDGENFGKGRSFQLCVKGNDDGENESPTQAPIDYLPLSTMDQTPKQPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIZ5</accession>
    <name>A0A914BIZ5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075880.1">
        <property type="nucleotide sequence ID" value="XM_038219952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219952.1">
        <property type="protein sequence ID" value="XP_038075880.1"/>
        <property type="gene ID" value="LOC119743529"/>
    </dbReference>
    <dbReference type="GeneID" id="119743529"/>
    <dbReference type="OMA" id="HYTAEGN"/>
    <dbReference type="OrthoDB" id="5876368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="157" mass="16993" checksum="361F3496BC12B1EF" modified="2023-02-22" version="1">MMGRHKAYRSNPNKRRRMRFVPQWLEKHAVSDGSSQLPPANSINDPEALRELIHYTAEGNVIAVRLLARAGVNVNMTDEDGWTALHYAADEAQRDVAQLLMGECGADGSIRSHEGLTAADVARMDGNFELEKLLDPSAASSAGLTDSTPSSSSQESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKF4</accession>
    <name>A0A914BKF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076757.1">
        <property type="nucleotide sequence ID" value="XM_038220829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076758.1">
        <property type="nucleotide sequence ID" value="XM_038220830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076759.1">
        <property type="nucleotide sequence ID" value="XM_038220831.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076760.1">
        <property type="nucleotide sequence ID" value="XM_038220832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076762.1">
        <property type="nucleotide sequence ID" value="XM_038220834.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076763.1">
        <property type="nucleotide sequence ID" value="XM_038220835.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076764.1">
        <property type="nucleotide sequence ID" value="XM_038220836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220829.1">
        <property type="protein sequence ID" value="XP_038076757.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220830.1">
        <property type="protein sequence ID" value="XP_038076758.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220831.1">
        <property type="protein sequence ID" value="XP_038076759.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220832.1">
        <property type="protein sequence ID" value="XP_038076760.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220834.1">
        <property type="protein sequence ID" value="XP_038076762.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220835.1">
        <property type="protein sequence ID" value="XP_038076763.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220836.1">
        <property type="protein sequence ID" value="XP_038076764.1"/>
        <property type="gene ID" value="LOC119744740"/>
    </dbReference>
    <dbReference type="GeneID" id="119744740"/>
    <dbReference type="OMA" id="PSVQQMF"/>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="782" mass="80481" checksum="B17287256A9795FC" modified="2023-02-22" version="1">MFQRAGSKFMGGGGGNFSNDFGYPAGNGGMGGNNTGFGGGFGRGGSRGGAGFGRGSGRGAGRGVGGIRGGSSRGGATRGGGTKGSATGSGAGSSMTETASRSESGYLQDHPGHFPDQYWCKICNAKTTGENNYNAHLRGVRHKQNVMNLQIGEPLQRVGPLAQRKRKRDSENTVKKVLSEMLPGNTEPVVGLEFVTEIIREGSDTDPDYECELCDCRTLQGNIIYHLIGFRHRMAYIKKMKPELHEQLDQMAKMAAENDVSKAGESGDPTPEEKEASKKRATRTRLSEKLREIMPDLAAECRGLKHKVKRVKGENMGVPVPKKPFSMQGGPGGRGGVAGGRGGAAGGRGGGGFGGRGGAFGGRGGVAGGRGGAFGGRGGGAPGGFGGAAAGRNGAARGRGGAARGRGGPNAGRGGFGGPGSYGGPGSFGGPSSFDGPGSFDGPGRFSDLVNVIGPIGGLGGEGLCGGGLGGGGLGGGRLSGGLNGGDRGQFGGSSLDSGGLGRGFGRGALARGNGGFDDGLSMRDRGRGLGAYEERSDLGGGYDLPPPSRREEIESIKSEILDSLTSNSAMSDAFILKEFERRFGSAKKLQRSDMYDDYDRGQDLGQDRSRFRDTIGEEQEQGGFQRLHSSQDFDSPSTQPFSDSSSQPRMTVSLDQLSRLDPTPKPPTGLRSCLKKPSSSSTTTSASTSMSYNMGGQSSMATGSSKAVQEMFANLSQSMITNETDAHLAKQVTDTLSQALKMYESKQGGDRPEPGFGEPPRNRGALLPPPAAPFGSGYSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLD1</accession>
    <name>A0A914BLD1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076735.1">
        <property type="nucleotide sequence ID" value="XM_038220807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLD1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220807.1">
        <property type="protein sequence ID" value="XP_038076735.1"/>
        <property type="gene ID" value="LOC119744726"/>
    </dbReference>
    <dbReference type="GeneID" id="119744726"/>
    <dbReference type="OrthoDB" id="10071823at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53403" checksum="73F68A177B28235C" modified="2023-02-22" version="1">MATEMEQTAMQELLIQQVIEIAESNVDVEIIDDQFVPGQASLSPVKWKRSTKQYKRICKPKLVDALGYVYNVKRVRAHGATDWQCTARGKSISCRATVKQKKGGFIPGPQPHVHMAESQIDTTDVVDGTNAKSKTTKKAKKAKKAEKPVKMTKAMLSSMKAEIPDSKYRKSKKLAKLQNIVNYQKPRLVDNRNGFTYSIKRVRNEDTSWKCILRDSTIKCPAVLRQCKEQFALGSKPHNHEGGIQVETVPKTQKAPKAKRKQKKCIAEQAWDIVNDGGANTSEPPVALLASEPQTSRLSEEAQAAGYRFLQSSSQRCRPRLVDSQGFMYNVKRVRKKAVDWQCTVRSKKMRCPVFLKECDGVITPGPHQHTHAPEPGALVKSVVKAAIKAKAIENFNQPTKEIVSQVLTQQVSEEPTAAVLSPVNLARMAYRAREGKKKLYFNNILCGLARFHPDGTGSWAGGNVDDGDSDNSSDSDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BME9</accession>
    <name>A0A914BME9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038076647.1">
        <property type="nucleotide sequence ID" value="XM_038220719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BME9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220719.1">
        <property type="protein sequence ID" value="XP_038076647.1"/>
        <property type="gene ID" value="LOC119744659"/>
    </dbReference>
    <dbReference type="GeneID" id="119744659"/>
    <dbReference type="CTD" id="201595"/>
    <dbReference type="OMA" id="TKELWSP"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="20">
        <location>
            <begin position="72"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="21">
        <location>
            <begin position="605"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="784"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="794"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="843" mass="95522" checksum="D940897A9D467A3D" modified="2023-02-22" version="1">MAEHSGQYDAANTAKRNQNPPQMASKSPGNRHKNVQKSTKNQDPGEEVELVQAPETEQLRFPSTSKAVEGLLTFLILFLACLAAFSSRLFAVIRFESIIHEFDPWFNYRSTHHLVSHGFYNFLNWFDERAWYPLGRIVGGTVYPGLMVTSGAIHWFAHLLNIPVHIRDVCVFLAPLFSGFTALAAYGLTKELWSPGAGLLAACFIAIVPGYISRSVAGSYDNEGIAIFALLFTYYLWLKAVKTGSVSWAAATALSYFYMVSAWGGYVFIINLIPLHVCVLLMMGRFSYRIYVAFSVFYILGTVFSMQVPFVGFQPVRTSEHMAAAGTFALLQAYAFLKYVQDFLSKKEFRALFFFGVMGTAGVVFLSVVLLTYAGFIAPWSGRFYSLYDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFVIKDINDERVFIVLYALSAVYFAGVMVRLMLTLTPVVCILASIAISKTLTEYLDNDTGSGGKKKVEEEGEETEEDEEEVDRKNRKLYDKAGKIRKPKLDQDKDSDGMGTNLKGFVVMALLMMLMMFAVHCTWVTSNAYSSPSIVLATYNNDGTRNILDDFREAYYWLSQNTGEKDRVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSNETQAYKIMRELDVNYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESDYFTVNGEFRVDSSGSPTLLNCLMYKMCYYRFGEMQLDFRSPAGYDRTRNAEIGNKDISFKHLEEAYTTEHWLVRIYRVKPLDNREPSTDKVSKKSKKKFYSKKTSKRKRGSIKNKPVVKKGKRKTTTRKSSSKTTGKKQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPS6</accession>
    <name>A0A914BPS6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078278.1">
        <property type="nucleotide sequence ID" value="XM_038222350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222350.1">
        <property type="protein sequence ID" value="XP_038078278.1"/>
        <property type="gene ID" value="LOC119745761"/>
    </dbReference>
    <dbReference type="GeneID" id="119745761"/>
    <dbReference type="OMA" id="DRISAKC"/>
    <dbReference type="OrthoDB" id="10051479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="557" mass="62277" checksum="2365996E5AA288AD" modified="2023-02-22" version="1">MYHSESGTCPPVRGGLSKRKVSPMTAEELSIDDGRATGPDQPQAPDAEQTGLLYVVSHRLAESGAHGIPNIQRANSTCRRLVWTVLFLAGFGMFIYQGTVLVIKYYSYPINVNIEVRTPKKVQFPAVTWCNLNPIRKDALRDYADLNSLLEGSNPECTTSSGNSSFQPRKRFQGYPSDWDSADIDYSAEDCDRQTFDSATDIVGAMPYSERSKTGHHLNDMLLKCTFQEKPCSPKNFSTIYNSRYGNCYTFNSGFKGVEAINVTKVGPTYGLSMELYIQQDLYITGVETGAGVRIMVHNQTDMPFPEDKGANVAPGTESFIGIFRVMVNRLPLPYGDCADHFVKDNIFKNQFGHLEYTKTACEKDCYFKEVLEQCKCADVQYRYDDSIAACNSSIESEENCIDEIQQNFTSGVLDCTHCHKSCNETRFERSFSHSIWPNHDYKDTVKENIQKSNKDTVDLMRNNSAFIEENVLRVNVYYDSLFYDDIYQSEAYPSSSLASDLGGQVGLWIGVSVLTVFEFVELMMDVCVLAMSKCRAGGEKGRAGKSSEHGKGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPS7</accession>
    <name>A0A914BPS7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">maleylacetoacetate isomerase</fullName>
            <ecNumber evidence="5">5.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038078144.1">
        <property type="nucleotide sequence ID" value="XM_038222216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPS7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222216.1">
        <property type="protein sequence ID" value="XP_038078144.1"/>
        <property type="gene ID" value="LOC119745683"/>
    </dbReference>
    <dbReference type="GeneID" id="119745683"/>
    <dbReference type="CTD" id="2954"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="212" mass="23847" checksum="B03E9D48F7B2DCF2" modified="2023-02-22" version="1">MAGKPILYSYFRSSCSWRVRIALAVKGIDYEYVAVNLLKSEQLGEKYRSVNLTSQVPSMEVDGMVLTQSNAIIEYLDETREGPSLLPKDPKKRFLARQLSQIISCGIQPLQNLSVLRYLGDERKVEWAQKVITGGFEAFETLVDQSSGKYCVGDEVTMADLCLVPQVYNANRFKVDMSKYPAISRINAALLELDAFKVAHPSKQPDCPEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSF9</accession>
    <name>A0A914BSF9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078905.1">
        <property type="nucleotide sequence ID" value="XM_038222977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSF9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222977.1">
        <property type="protein sequence ID" value="XP_038078905.1"/>
        <property type="gene ID" value="LOC119746166"/>
    </dbReference>
    <dbReference type="GeneID" id="119746166"/>
    <dbReference type="OMA" id="MDRHTES"/>
    <dbReference type="OrthoDB" id="10038550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617127" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56431" checksum="32C6705872A0B848" modified="2023-02-22" version="1">MDRHTESFICFSIFVFLLRHTAHCEECSETFTQAPGKLNRLLNASLWTTCKFHFRAPVDSSVVLSVTSLRGFASVGSGGRCLPRLIFKNVGPSGTTHLLTVQAIQEGTLPIIVQSLDNELKVVFRGHTCTEQMSSFDASYSFHSRVGRKAKYQESYPLVRDVRKTSDRSVLTTPGADDITTTLQDRNATHHDDDNKSQENNSSLHLFFLAILAPITLVCLLCCLIMYIRQRNDLPMPPFHHRSQRLSMSTPSDTTPPTSELPLIPGRPFSSEEQQEMLRQQRETVCRRSESTEDYPSTVVHYDEEAHPFMRSLRLFNEDVCRSGIRAPPNRTVFDSIESSLSMKQQQQQAPPKKDSKKGTVHRTDSLNRAGSPKGKPGLQVLDSETKTPLKLLDPDSEGPPPYLAVVKKQQQQQQPSRPSSEVINVCDRSHSHLVAALSEPSVQRPAVDTWPLPHRSHDAATMPSTLPQEAQPSSRHSPTLSPPQGRKEESLSRRCESTDIHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z051</accession>
    <name>A0A913Z051_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045042.1">
        <property type="nucleotide sequence ID" value="XM_038189114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z051"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189114.1">
        <property type="protein sequence ID" value="XP_038045042.1"/>
        <property type="gene ID" value="LOC119719616"/>
    </dbReference>
    <dbReference type="GeneID" id="119719616"/>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="488" mass="54352" checksum="069437DA6BA4C11B" modified="2023-02-22" version="1">MMMVGNLDQIGACLISKAAWWRYTTCLEYRSLKICCRKCTIMTMPEKRAKVWCSAPNCTNNPKKTPHNSFYRFPKDSERSAKWVVSTGRDDLRDRPADYRYRNCRICSEHFEKRQILCTGRLVWNAVPTVFSVSDLPPKRKRARRGAGTGSTGPTTTTTTTTTTRSPEKTCEQDSDVSPDTEQDPADHSYARATETTEASTTSEASTTSEAGTTSEASTTIEASTTIEASTTSEASTTSEASTTSEASTTSEASRCDVQLQSTPSQTDPVLTLTEAPPDTAEVATMCNLAKSTDRVKIFRLKKKVKVLKASAETTKDPTVTVKDIVEESAKYLDETTLHFFESQLQIGTKRTKGRRYTNSDKRKAYALLCQSPAAYRFYRKLKLFALPSDRCLRRWLKSAPAQQGLNDASFEGLKQTARTMSERLYSAVKLYNQDLTKGKIHKKKKTDKKAKRKDKQLPAPVCETSLEAVEAVESVYSLLAFAQEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z082</accession>
    <name>A0A913Z082_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactosylceramidase</fullName>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactosylceramidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 59 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038045329.1">
        <property type="nucleotide sequence ID" value="XM_038189401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z082"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189401.1">
        <property type="protein sequence ID" value="XP_038045329.1"/>
        <property type="gene ID" value="LOC119719924"/>
    </dbReference>
    <dbReference type="GeneID" id="119719924"/>
    <dbReference type="OMA" id="SXSHKHS"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006683">
        <property type="term" value="P:galactosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000091">
        <property type="entry name" value="galactocerebrosidase precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000026">
        <property type="entry name" value="galactocerebrosidase precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049162">
        <property type="entry name" value="GH59_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001286">
        <property type="entry name" value="Glyco_hydro_59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035394">
        <property type="entry name" value="Glyco_hydro_59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172:SF1">
        <property type="entry name" value="GALACTOCEREBROSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21708">
        <property type="entry name" value="Glyco_hydro_59_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17387">
        <property type="entry name" value="Glyco_hydro_59M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00850">
        <property type="entry name" value="GLHYDRLASE59"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036735437" description="galactosylceramidase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="14">
        <location>
            <begin position="39"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 central" evidence="15">
        <location>
            <begin position="342"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 C-terminal lectin" evidence="16">
        <location>
            <begin position="492"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601286-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="666" mass="73883" checksum="B4CDEB9964925BA8" modified="2023-02-22" version="1">MSYFIAEVFHILFVLQLIGSYSVASQYVISDVPGLGRRFDGIGGLSGGGATSRLLVNYPEPYLDQILDYLFKPNFGASLHILKVEIGGDSQSTDGTESSHMHSANDENYQRGYEWWLMKEAKKRNPSIKLYGLPWAFPGWIGNGQQSPYVNIDVTVDYIIKWIQGAKTHHNLTIDYIGIWNERPYNSTYIKTLRSSLNKAGLSHIAVVAADGKLAISRDILMDKALAAAVQIIGLHYPGTHVTNYTLETGKTIWASEDYNTHNNEVGAGCWARTLNQNYVNGMMTSTISWNLIASYYDALKYARAGLMTANEPWSSHFEVTDTIWISAHTTQFTDPGWMYLKHKSGVQRLDKGGSFVSMTDGVNLTIIIETMSYDHSKCTWPYLPPYSVAAQTAKFTLQGSFAKVSSLNVWYSKLTFNGQSSTIFVKKNPIKVVNGSFTLSLNPDEVYTLTTTERGYKGNYPTPPPSAPFPVPYSDNFDNYPEFSEASNFADQAGVWEIRESGDPTHKLVMEQVVLESPVHWCPAAESPISVIGNYSWQNADVSVDVKLGDNTGAFLAQRINDGGCKVVVATGLFFIVYSNGTFAVYSDIHHRFLLNSGQVDVKSDMWFNMRLLIQDSKATGFVQGKTVFTASLDPKTIPSHGFVAMGMPNYASAQFDNFDIISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z436</accession>
    <name>A0A913Z436_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045485.1">
        <property type="nucleotide sequence ID" value="XM_038189557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z436"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189557.1">
        <property type="protein sequence ID" value="XP_038045485.1"/>
        <property type="gene ID" value="LOC119720047"/>
    </dbReference>
    <dbReference type="GeneID" id="119720047"/>
    <dbReference type="OrthoDB" id="9944627at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="35828" checksum="F2F972ECA6B4D6B6" modified="2023-02-22" version="1">MEEILWLRIFNTIIGIVGVLGNGLVCVVIGKVSSMHTRTNAFIFHQAVVDLLGSLMTLLQNEAPIPDPMPNNALGWAVCRVWYSRFALFLIYVISTYNLLSLTMERYFAIVHPFKYQAAFAKRPRLKVGVVIAACWIIGTVINSYVANAFKVQDGRCVSSAAYRSKVIGGLVAILQYIVPVAVMLFAYIRTSVELKSGAARVGPAPANVGPAAGASTTDGNAQPEGMMESLLRARRNTFKMLWIVFITFLVCWTPNQVLYLAFNLGWNLNVENGFYRLSIAMVAANSCVNPAIYAFKYRQFRKGLREVFCRRLMRLDEASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z444</accession>
    <name>A0A913Z444_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045776.1">
        <property type="nucleotide sequence ID" value="XM_038189848.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189848.1">
        <property type="protein sequence ID" value="XP_038045776.1"/>
        <property type="gene ID" value="LOC119720231"/>
    </dbReference>
    <dbReference type="GeneID" id="119720231"/>
    <dbReference type="OMA" id="SSWHEND"/>
    <dbReference type="OrthoDB" id="5966313at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF13">
        <property type="entry name" value="PROTEIN CRUMBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17963">
        <property type="entry name" value="Big_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2105"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="15">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="14">
        <location>
            <begin position="157"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="13">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="16">
        <location>
            <begin position="313"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="818"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="859"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="899"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="940"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1105"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1151"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1321"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1479"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1519"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="1559"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2039"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1589"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2070"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2244" mass="244163" checksum="52840BB213CD4B53" modified="2023-02-22" version="1">MIAPFWADVQAEAFDSTNNVFWQLYDNPSTDSTMLGTLSNIVSAQYDSFLANWVLVITWSNVQAVSLSPETNTFQAILLTNGAHSYVVFNYDPCGMNWDPAYLANPNVIQGFNPGRFEQKVYVDLPPGTSVFRPGSVVGNSGMMGRWVYQLDTLQDNFINPRLFCYNWYDQQRSNFFLDLYAASVANTCPCSLQSARRDRRWVPIPYVLPTQFSLGFDTICYVRRLQFPWLPGPQCCYNIPRCDFLRGVLSAGVASVMEPFQLSPLFFSNSRFNSWFDQGFLVRYYCCEQSSLCRLYRRWRPIQSCRRYRPPRWSWTFGDPHMRTLDGLEYTFNGLGEYTITLINDDSGQRQFELQGRTQRVLNSETQQLSEATFFTGFAAEYVGDARIEIKLNSDGTDLETKVNGASVTPTADGLLIGNFTVLREENPIKIIAVYQADIQFSVGVSNSFADITTQLSEDYMNKTKGLLGVWDGDTSNDALRRDNTQQTATGTDGELSEQDFFQFGQTWAISESDSLFYYVSPGESFSNMNDPSFTPKFLDDLMSEADPAKLQAARDACGSNKVCLYDALATGSTDVGVASMQLSEQNSIDNMAATNFPPNVTLVETVEVVVGQPFTLQIEAVDPDGDDISYELLEVIPGGTVTSPGGQFTWTPADRSKVTLGFLVTDGKANATLEPIVKLCDCKNAGTCLYDEYVEGTNVITDGRFGVVLCNCTPGWSGDFCEMNYDACQDNPCFLGVACFDDDPPSLNFTCGSCPEGTEGDGKSCIDIDECVVYRDEPASNGGRGCDQNCVNTLHSFNCSCNSGYSLFVDGKRCIEINECDQQTDDCAVEATCNNTQGGYECSCNAGFSGDGTSCQDINECSGTNDCDSGADCSNTIGSYRCQCRQGYEGSGFTCTDVNECSRDTDECNIQAMCDNTQGSYTCTCNEGLSGDGRNCTNVNECEGSTPVCHVNATCTDIPGSFTCQCSAGFNGNGTDCQDIDECDLEIDNCLQNCRNTIGSYECVCHEAFTLRDGSCVATTNCSENSICVNGDCYVNGADIETCLCYRGYQNSSDPMVCEDINECNATESYCGPSSTCNNTAGGFECLCSAGFRQGNNQRDCLDIDECTLPVDDPLYPVCIPTANCYNDHGSYDCRCKSGYGGNGTHCQNVDECQNGHSCVADSTCLDNDGSYTCQCNTGFRGDGLVSCMNIDECLEDPDICHALATCSDTEGSYRCNCDSGYQGNGTYCEDDDECMANSHDCASGRADCVNNVGSHTCTCMNGYLSAPGMLPGRQCDDIDECALNLDSCDVLVSRCNNNEGSYVCDCLSGLVMLDQCIDINECHYPNTCGAMANSECVNLHRSYECQCRMGFYRQNSECLSGVSYNASAVFDIISGELVGGNGFNLVANYLTYRAELKDAIEAAFRSSVLSGYFGDVVISEISLLTDSMALLRLVINLNMSQPEQFIIDAFLSQLTGGSGGQLAPNHRLVSSTFIIGDPKCNSSPCTNSGTCADDNSVLPEGYTCTCLPGYSGHNCEIAPCDNNPCMNDGTCRVNSTTVTGYMCECALGYSGPQCQTIVPCELSNDCMNAATCVNEFVNARGYTCMCADGFMGENCENECSLTCMNGGTRDPATCLCVCSSPWTGDTCTECSLTCMNGAARDSDSCRCMCIPPWTGDTCTECSLTCMNGGTRDPATCLCVCSSPWTGDTCTECSLTCMNGAARDSDSCRCMCIPPWTGDTCTECSLTCMNGGTTDPATCQCVCSPPWTGDTCTECSLTCMNGAARDSDSCRCMCIPPWTGETCTECSLTCMNGGTRDPATCQCVCSPPWTGDTCTECLITCGNGATRDPDSCQCMCSSSFTGDNCTECPLTTASCMNGGTLDEEYCECVCPLTHSGDLCQDSNVCLTGDQCSDATTGRYCVPSNNAFTCQCRTYDAFFMEGAACENRRSFSLTVVITLLTETYRSVYINPWSSAFRAKAALYKRLVELRLRNDTATSDLISADCVSIQSGSVVATMVLLFPAAPPRTDVQRVLSENRPLTDVDVAITTDPPALRVNAVTDCPPDYCQNGAMCVKSGYYVSTFTYTCSCGTSFAGERCETVIPVPTEVPTATTTESPGGISTEVIVIIIVACVVLFLAVVVLLLCLCLLIRRRYIIASTRGWQKPDGPRINYGLSEYTDQSYYQDNGYDTSAMRDEEVRMDRLMNVMSRSPYLQQGLSSRHDFIRPYIVTGTEEFYQDNQHFDDPRDDDGMVGRVAYNPMIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4G1</accession>
    <name>A0A913Z4G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045620.1">
        <property type="nucleotide sequence ID" value="XM_038189692.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045621.1">
        <property type="nucleotide sequence ID" value="XM_038189693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189692.1">
        <property type="protein sequence ID" value="XP_038045620.1"/>
        <property type="gene ID" value="LOC119720137"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189693.1">
        <property type="protein sequence ID" value="XP_038045621.1"/>
        <property type="gene ID" value="LOC119720137"/>
    </dbReference>
    <dbReference type="GeneID" id="119720137"/>
    <dbReference type="OMA" id="WGLINNI"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="113"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="195"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="54369" checksum="E7AE30335B0DE88A" modified="2023-02-22" version="1">MATYIQVVEELTDDEAIELPVEPDGTMLLSTLTAQFPCASGLKYRNPGTGSLRGLRVVDGGIQPPDGVWGDHLYIAVFPKDNKRKGEDNQEKTNSAKTRRVDQLQGITHNKTVDLIVLGLAWKTTQAGMREYFEKFGELLICELKLDRDGNSKGFGFVRYKDMEAQNKVVSMRHTIDGRHCDVKFPDSKVQNYNNKMFIGRLTSDMTKEDLYEYFSQFGEVTDIYIPKNFRGFGFITFLRPEVAARVANEDHILKGTSLFISDAEPKNSRKTAMNSPENNQMGMFGGQNFGGGFGNQGQYHSRGDYSQGARRGGRGGSSMGGGGGSYRDYRDRDQGGMGGQVPNSPGMGGGGMGGGMGGGMGGGMGGGMGGNPGGQGPGQMGNFPWNQAMLAALSQAGWGMMSNMLAQGMQQGLQQQQGNQLQQQQQQQQQQQQQQPSQQPQVGMSQGSGGSGVPNQQPMQQNQGGGGGGGYSSGQQSLGWGAVQNNTNESPGTGYLMGDSKPGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4I6</accession>
    <name>A0A913Z4I6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046748.1">
        <property type="nucleotide sequence ID" value="XM_038190820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190820.1">
        <property type="protein sequence ID" value="XP_038046748.1"/>
        <property type="gene ID" value="LOC119720953"/>
    </dbReference>
    <dbReference type="GeneID" id="119720953"/>
    <dbReference type="OMA" id="IGPACEY"/>
    <dbReference type="OrthoDB" id="5867643at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036862378" description="Receptor ligand binding region domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="260" mass="29553" checksum="C6A106BCACB557ED" modified="2023-02-22" version="1">MLVGTAVLLSLPAPVHLIRQCQPHDKEQDSLLTSLTMSVLLPGYPVPRLPPNRYYPFFMQMVRPATDMALQRYSEILPNHNVTVLYGNTLCESGIALNTALVDWLDHGADVFIGPACEYTASQVSRFLGFRNVPMVTGAAMAMGFRRDGDHPTITRTQAPYNKMGEAVRDFFVQFAWNHTVMVYRKEDVPISDCKFAMGSIYRVLLEHGFQTTHGDFEEVIFKDRDYITMLEEEVMPKARSKLLLPLSQSPRLLFLLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4J6</accession>
    <name>A0A913Z4J6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046692.1">
        <property type="nucleotide sequence ID" value="XM_038190764.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046693.1">
        <property type="nucleotide sequence ID" value="XM_038190765.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046694.1">
        <property type="nucleotide sequence ID" value="XM_038190766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190764.1">
        <property type="protein sequence ID" value="XP_038046692.1"/>
        <property type="gene ID" value="LOC119720897"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190765.1">
        <property type="protein sequence ID" value="XP_038046693.1"/>
        <property type="gene ID" value="LOC119720898"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190766.1">
        <property type="protein sequence ID" value="XP_038046694.1"/>
        <property type="gene ID" value="LOC119720899"/>
    </dbReference>
    <dbReference type="GeneID" id="119720897"/>
    <dbReference type="GeneID" id="119720898"/>
    <dbReference type="GeneID" id="119720899"/>
    <dbReference type="OMA" id="GANDCAH"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="141"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="179"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="275" mass="29530" checksum="5C8DD313F18E0AD7" modified="2023-02-22" version="1">MAKMNPTVTTIPLSHPTPAAVQMRNTVAPTVDVNPPSSVLRLVNGSTIYEGRVEVFVNGSWGTACSHSWDMNEAQVICRQLGYGPAINAPGYATYGPGVGPIHLVHVHCNGSESSILDCTSYYSEHCSHSEDAGVECSAPVRLVNGSSSNEGQVEVFYQGEWGTVCDDGWDLNNADVVCRMLGYPSASNAWSGAHFGQGSGPIMLDNVNCQGYESSIAECNHAGWFSHNCGHNEDAGVTCNSDSTTEPPYSGCSSYEWQCYYNGQCIQDYQRCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4K3</accession>
    <name>A0A913Z4K3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045663.1">
        <property type="nucleotide sequence ID" value="XM_038189735.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045664.1">
        <property type="nucleotide sequence ID" value="XM_038189736.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045665.1">
        <property type="nucleotide sequence ID" value="XM_038189737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4K3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189735.1">
        <property type="protein sequence ID" value="XP_038045663.1"/>
        <property type="gene ID" value="LOC119720170"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189736.1">
        <property type="protein sequence ID" value="XP_038045664.1"/>
        <property type="gene ID" value="LOC119720170"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189737.1">
        <property type="protein sequence ID" value="XP_038045665.1"/>
        <property type="gene ID" value="LOC119720170"/>
    </dbReference>
    <dbReference type="GeneID" id="119720170"/>
    <dbReference type="OMA" id="NIYECAN"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="258"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124305" checksum="3FDC29D66B21DD81" modified="2023-02-22" version="1">MQQSAAACQWTDVPTTMQQSEAACQWTDVPTTMQQSAAACQRTDVPTTLQQSETAYQRTDVPTTMQQEAQVPAPSFATDSPQQTGTIEDLGAVGGSNYPTVSGSSGVNVTYNFPLEGPGVPAPRLLHSRRPDQDPKLTDPCQEAGVPAPRPQQSQRPDQDPRWTDPSQEAGKKTRDVLKGVYKTTCSSVKLLPGVDNDQMHIAGINTKVQFKTREGRAFVTGQEDIITSTDYSKIFRRRARFGELIKRLIFFGTGIVGVSTMFDKIAYDWADETSEILNGFKLVFLLKMCALSQKSDLVDSTFDQLLGKKSGIEKDELDQFILANPNEVLILLDGFDEMKTKKLNAASFGSILKALNRTVYKECLVCISTRPSHLKILMPLMSLMSETLVQDPCTHVEVLGFTDEDVNDYVQKFYDKDPDIGKALIQTIEKSNTLRYFAKTPVLLFLMCLLWRKSKQLPKTTSRLFTEAIDHMFTRKHLSGYYASNTVIAIGKIALHGLTSANQKFSFQEDEFEPKALELALKAGILTQQRVIKNKSNNNIKFMHKTVQEYCAAKYLQSLNLSSTVGLLTRVKNKLNMIKYQRILNQLCSTFEGVVSNEFLFRFCCGDNEKCMMDIVNLLDRKFNKDRPRYQSSVIQAISRNCFLESQSAKVPLCLTSDSLIPSTIEVFKNDDFQSLMYLLEIICRSDSCKMQLARVTDISISRVSAVSDLAFVLGYMENLRSLRLYRCSSWNGGHVKILSSLKCNQHLTDLGLNISSRRAVEWAPHIKHLTSLNRLELACQALGWDSMEHIASAVANMPKLTDLSLATNVRLGGTVNLWTTELLKMRHLNRLDLSDCSYSVSDAEHIIATVADMPKLTELILAGNGNLIGNAKLWAKELPKVTHLNRLDLGNYVLDPTDIEHIASAAGDMPRLTDLILAGNRRLGGLAELWAKELPKMMHLKKLDLKHCSLLPTDIEHIASAVGNMPRLTNLILAPNWKLAELAQLWAKELPKMVHLKRLVLRECKLTPSDFEHIASAVCNMPSLTDLILDKNKALGASAELWATALPKMRHLSRLDLSHCNLTPSDIGRVTSAVGDMPSLTDFFLAGNPGLDGLDELQSRLPSLNVHVETHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z720</accession>
    <name>A0A913Z720_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046623.1">
        <property type="nucleotide sequence ID" value="XM_038190695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046624.1">
        <property type="nucleotide sequence ID" value="XM_038190696.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046625.1">
        <property type="nucleotide sequence ID" value="XM_038190697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z720"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190695.1">
        <property type="protein sequence ID" value="XP_038046623.1"/>
        <property type="gene ID" value="LOC119720839"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190696.1">
        <property type="protein sequence ID" value="XP_038046624.1"/>
        <property type="gene ID" value="LOC119720839"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190697.1">
        <property type="protein sequence ID" value="XP_038046625.1"/>
        <property type="gene ID" value="LOC119720839"/>
    </dbReference>
    <dbReference type="GeneID" id="119720839"/>
    <dbReference type="OMA" id="WANGQIC"/>
    <dbReference type="OrthoDB" id="10061577at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="821" mass="87945" checksum="CB7030D23783DBFB" modified="2023-02-22" version="1">MVMMDSLEKARRKRMVDCAVQFQNVNAEDLMPYLKCLPRPQKEKILCKQRLDGALAAAQMLGMALVKVDNWFEQLIPALRELNQNELADLLDDPPEDKRLENHRDVGLQSHQEKKGKFSPNQEKNLHQSEAGQSTLPRPSTSSGQSLKVTLQTPYSQLSALILHVLRRLDVLSPATGNDWTGLAGQLGFSIDSVNRFRSQQGSPTEALLLEWSNEGAATLEKLINALHDMHREDICQQLEELLGLRLELRNNQDGNTAEPRPTVSVSSRPLTEQDQQSELAARPQVTDTAPNQPAVDTEVEEEAKLVAPAPRPQPEAVPSHAEESGEDVATESENAAKKESDTSPKPQNSQSTETSKADASIVKHPEAEKVEVPSAHISCKDSQPPVNNLNRKHVESDHANCQVKTQLSDDPETCSDNNPGDGYSTGYIHVESNVCDCYHSLKTDDELDRDVSLQMSEESVPTIVPVASLDAGTSGASAGDDPTSSSSQESSSATTALSASATSVAPATVGQAVKKDSCDGFAPTVKILTSSQGAPVRQASGDSKYHLEQFQVPSVDGAFPEAAWMRATAFKSTSNPEASSSIRQVRKPVKQQQLCDAKPVADQVGPKPSQPDKDSQDPAPKPSHLNQQKIGESQKKQASSAVDSQHQHHAQTKSPPTPLAPHEEDGSGGNPELSGSEKQEASTETQCDPPPIPQLVESTQLLPSTTNTPSALQASPQRTQEVDSTGCLEESGAKSPEASVPLRQEASLPDQDSIQPPHALADNTEDQGGDSQEPGAEDENTDATTESQGRGALVGLALAVPVVLSLAAALTGGDILSNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z756</accession>
    <name>A0A913Z756_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047557.1">
        <property type="nucleotide sequence ID" value="XM_038191629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z756"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191629.1">
        <property type="protein sequence ID" value="XP_038047557.1"/>
        <property type="gene ID" value="LOC119721546"/>
    </dbReference>
    <dbReference type="GeneID" id="119721546"/>
    <dbReference type="CTD" id="84302"/>
    <dbReference type="OMA" id="IGRPYFL"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22190">
        <property type="entry name" value="PGAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="438" mass="50338" checksum="A98DEBA0FA8266B9" modified="2023-02-22" version="1">MPAVMSCLIPTRLLIWLYTSSSNAFFQWKGAFVKTATVYGVTFLLVLPLLCHNLPYSVYFIAPHDIEQRPVRLNQHRVEEAEQYLSKLETNGPLKALPTSSNLQIAIGVVSVSRKVKTVNTKYLTQVMVGLHDIITRAGVADKVFAFICNTQKATQTHPEADDLASYFHVARFPPNRTRHNAWRHEEEKESYSFCLETAAKFNARYVLLMQDDALPHANFYEVVDHLLRHRLESTVSQGQPVDGAHDWGWLKLNFPNEFANYHRSPFFVFDWVALSLVGASLTSIVYTIYTKQDPPAIPNPPQKKTYRNRHSWTTYYIFVVSFGYFFLAVWLIGRQYFLRLYGLSKYFARLDPGTTCCIPAVLFPQERVAGLVEYLNDVFCKPGFPLDFALEVYRERENLRQYLAVPNLFSHIGFYSALRGGTNRGLAYAFLDEFTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9S4</accession>
    <name>A0A913Z9S4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048379.1">
        <property type="nucleotide sequence ID" value="XM_038192451.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192451.1">
        <property type="protein sequence ID" value="XP_038048379.1"/>
        <property type="gene ID" value="LOC119722377"/>
    </dbReference>
    <dbReference type="GeneID" id="119722377"/>
    <dbReference type="OMA" id="MERENNQ"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="539" mass="61252" checksum="FD0F6ED3D0DE52C5" modified="2023-02-22" version="1">MALKSNFRGPSRPSTSAMGSSEPADCTVKLKSNSTRKYSIMQFNRGDNVDLSKWKQAKMERENNLKEFKMLNPDMPTSGAGSEFGRERREEARRKKYGIRAKKYKEEDQPWILKQIGAPGKKYKGKKEGLISENSSYYVFKQLADGSFEAYPVEAWYSFSSVAKHKTLNAEEAEEEFGRRDRTFNFFSLMVKKRLKESVGETLSKEDEEEMKAKAKTSKRTAGLRITEDDDYQDLMTSEESDAYMSDEDDDAAKSKAKTKGGQKPRKRKKKKQESDDEGEEESDEGDFEGRELDYISEDSSDDEEEQKKIDIKGLDEELQKIEDEEEEEEEEKEKEKEGEEXKDQVDGKEESAKKEDASSSSSGSDSDDSDIDDTKIQSALLMQKKPSKRPATPPSQKMPPKSGSRNTSRPETPTQNPNANSPTTACTLSDAATKLQQERVSLKRPGTEEGSSSKRVKTEGDQSRGRTPGKEAVGLTEDIVRRYLMRKPMTTKDLLYKLKSKKIGLQPDVMVKRLAEILRKLDPKQTKIKDKTYWSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBG4</accession>
    <name>A0A913ZBG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048381.1">
        <property type="nucleotide sequence ID" value="XM_038192453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192453.1">
        <property type="protein sequence ID" value="XP_038048381.1"/>
        <property type="gene ID" value="LOC119722379"/>
    </dbReference>
    <dbReference type="GeneID" id="119722379"/>
    <dbReference type="OMA" id="MAFFHCI"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="201"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55659" checksum="DBA0A784FE001038" modified="2023-02-22" version="1">MIRNGLKILRNFRPYSPRLPCSVWPPRPLQTGQGNARGLSAMFTARRSLLQLPARPELSKIVPKPPRGYQSVNWYSSQASREASLDTHVKIRSLSKDDSRRMVNVTWSDGTKQDYPFVWLLDNCFCTDCYHVESQCRLLPFDELDIDANPESVETVNHGDTLRVSWNRHHHSDFNSDWLRPNRFDQAEPRDDALSALPTPKLWGAEIAQSLPRFEFQEVLSDDWALLDFLKAFHEFGIVKLERTPAEPNQIPILAKRIGPMRETSFGLIQPLRKGGYEVEDLGQDRALSYTTKALNLHNDMSCLYETTCMAFFHCIIASDGKGGESIYSDGFHAAEMLRLADPRAFRLLSTNQQEFRLVGAEPHVGDFDHRSHHFPIMLDHFGQLKAIHYSTHARTPSLRMAVDDVKAMYSALQSFSKLLESPENAYYVKLQKGDMVVVNNHRVLHGRTPFEDSNERYLELGYVDWDHVTSRMRVLQNKLNSDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBZ3</accession>
    <name>A0A913ZBZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038049298.1">
        <property type="nucleotide sequence ID" value="XM_038193370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193370.1">
        <property type="protein sequence ID" value="XP_038049298.1"/>
        <property type="gene ID" value="LOC119722950"/>
    </dbReference>
    <dbReference type="GeneID" id="119722950"/>
    <dbReference type="OMA" id="MPRDVYP"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="38154" checksum="2FD73675DD71BCE1" modified="2023-02-22" version="1">MTLRKSFLILAVVVISNVILLVFVLPSRYNFAWHRCLTTAHQPIKCNCTDSVKDTIVNSHEYKLLINEPQACYDTAGSPREVFLLVFIATIHAHTEQRQAIRETWGSPRDVRGKQIVTLFLLAQNKDAALQQQVEKESSKHHDLLQEDFQDTYKNLTLKTIMGMKWVSTHCRHASYVMKTDDDMYVSYDNLVKHLTDATTLSTNYAVGRLHKNIFPIRDPKSRWYMSKELYPGRMYPPYLSGAGYVVTGDLAGKIYQTSLKLQYLHIEDVFVGECLKSLNTMPKDNSQFTCWSNTEYSYCDSHRMITMHNFSSSRMRKLWSDHQRQTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCR7</accession>
    <name>A0A913ZCR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038048730.1">
        <property type="nucleotide sequence ID" value="XM_038192802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192802.1">
        <property type="protein sequence ID" value="XP_038048730.1"/>
        <property type="gene ID" value="LOC119722607"/>
    </dbReference>
    <dbReference type="GeneID" id="119722607"/>
    <dbReference type="OMA" id="NTDAGHM"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DED" evidence="19">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="19">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="18">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="18">
        <location>
            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="21">
        <location>
            <begin position="570"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="20">
        <location>
            <begin position="716"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="809" mass="90667" checksum="DC37900A5EBAF6AE" modified="2023-02-22" version="1">MVPQTEINWCNLNSRKGIGLGLQYLYNKISMASLATDAIPADPMAFRHLLKKLDDGLGSEDCHKLNFISADLGIPKAKLERVRQATDIFDELEKQSLIAADDVSLLWELMELIHRKDLLSIIHVYCNKHFVKELHTGQIGKYRLLLLEIADNTSNADMNCFKQACKDLLGRQAVSKLQNIYQLFPLLEERGTLAPSNLDILCQLLNLAGNIQMVQNVHQFESQGNLPDIELVQLSSRLVSEWRKLGTYLGLGHHVLEAIDHDNRGTEDKAREMLFTWRHNLSHREDAYGILSKALKLCYRMDLAEAVNDMARKHKQSALAHPHQDQMVSQPVQYQPVQYQPAVWSSQPHLMKPSDFCTTNAPSIPTHTALPVSDHGIPDQVLRELAEKITVEWQKMGTFLNMEHTVLRRINQDCHRSEEKAYNMLMVWRSQLKPGTDAVHVLASVLKIVGRVDLSEVLKGIACPSGPMARQLQSLDQRLTSQPMNVDPPAHPTTQAQQPMSQADAVPENTPSSCSNVTEKMEEMSINQSQGGQETSPIQQTYPETIVGNVGQGHVIAQPSLPEYRMNRNPRGLCMIINNVQFEGSSLTSRPGSEKDTGKLDNLFNKLHFEVAVKEDLTAHAMLDWFKRVSQLNHSDYDCFACCILTHGALGQVFGTDGEPVEIQQILGLFTGVSCRSLVGKPKMFFIQACQGKTEQEGVQDIETDEPERHGLGVGMSKTKPNEADFLLSYATVPGYVSYRSKSEGSWYVNALVDQINKHHNTTDMLNILTVVNKTLCDQNAQRKGSIRKQVPAPSYTLEKALYLRSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDM2</accession>
    <name>A0A913ZDM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="RefSeq" id="XP_038049878.1">
        <property type="nucleotide sequence ID" value="XM_038193950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193950.1">
        <property type="protein sequence ID" value="XP_038049878.1"/>
        <property type="gene ID" value="LOC119723353"/>
    </dbReference>
    <dbReference type="GeneID" id="119723353"/>
    <dbReference type="OMA" id="QMYGNDK"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000210">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1048"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="818"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1156" mass="131946" checksum="D474C41195924B1B" modified="2023-02-22" version="1">MSSFLRKITNTLLCKREDIPENRTIFVNHKHPPTDDVYFQQKFPDNKIISSKYTIITFLPKNLFEQFRRIANFYFLLVAVLQFLAIDSPVSPITSILPLIFVISVTAIKQAYEDWLRHKADNEVNKRPTQVVRDCHIKEVQSQQINVGDIVKVMMDEELPCDMVLLCSQNEDGECYVTTANLDGETNLKIFRSLPDTALLQDEEGLDALSAMVECEQPQPDLYKFIGRMSFYSPSQQPTVKSLSAENVLLRGSRLKNTHFVYGVAIYTGRETKMALNSRQKGQKHSCIESSMNKYLVAMLIWLIVQTGLATGLKYWTDRRDFMVKSWYVRPVAEAYGDLVSSATVIFTDFLSFLVLFNYIIPISLYVTIELQKFLGSLYFGWDVDIYDPKADLRAKANTSDLNEELGQVEYMFTDKTGTLTENDMQFRYCSVDGIKYTEKEGKLVPGNKSIATPEATREFLLCLALCHTVHVNKDQDGDEVDAPNPNEDYTLWQYEASSPDEKALVEAAQRFGVVLTASTQEYIELMIDGDLVRFQLLHILEFDPTRKCMSVIIKNPEGNVQVLCKGAESTILARSVSGQKDITLDHVNDYAVEGLRTLCFAKRELSPEEYEDFHHQLHEASTALDGREEKLTQVFNNVEQELHLLGATGVEDKLQDGVPETIEALRTAGIKVWVLTGDKQETAVNISHSCKHFKPHMQELMLVKQANAQECGETLWRFLEQMRAEPQVKYAMVVDGPSLFHALEHHKDTLRDLCLNCVAVLCCRMSPLQKAEVVKLVKFSDSRPTTMAIGDGANDVSMIQEAHIGLGIMGKEGRQAVRCSDYAFSRFRFLIRVLLVHGAWYYNRIAITVQYFFYKNIAFITAQFFYAFYSAFSEQTVYDSFSLTLFNITYTSLPILIYGIVEQHLSSETLVNNPRLYREMRQNAKLTWIQCIYWLVLGTVHALVIFYFSMLLFKDDASLYQDQKSMGNWCLGTILYTCCILIANIKLGIETRYWNWIVIGSMALSILGYPILTSIYTAFIWYKVLGGWDFFDSTDPYYVFFMSLKSWPVWFGILLTIAACFLPDFVYKTCQLYFFPSESQVANPTKQPRQQPSKPKQWTPKKPVEFNGRGRLNPAFEGEVATDAVDEGGLSLGTYKLAYQSEEDQTSKTTPITVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDU7</accession>
    <name>A0A913ZDU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038049130.1">
        <property type="nucleotide sequence ID" value="XM_038193202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193202.1">
        <property type="protein sequence ID" value="XP_038049130.1"/>
        <property type="gene ID" value="LOC119722839"/>
    </dbReference>
    <dbReference type="GeneID" id="119722839"/>
    <dbReference type="OMA" id="HAIECHQ"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF100">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038163055" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="17898" checksum="23A32DCB807DEC0E" modified="2023-02-22" version="1">MKLLLVLLAATVALASSAAVKKSDVSSVYQFGKFISCYGGAGFFDGLDYNGYGCYCGYGGKGTPLDDTDRCCQVHDNCYGKATAEADCGSWDPYVIIYDYEQTTDASGNCVIKCKKAADYSWYSTNPECREFMCECDRAGAQCFAEKRPTYNQAYESYDKDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFP6</accession>
    <name>A0A913ZFP6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050618.1">
        <property type="nucleotide sequence ID" value="XM_038194690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194690.1">
        <property type="protein sequence ID" value="XP_038050618.1"/>
        <property type="gene ID" value="LOC119723813"/>
    </dbReference>
    <dbReference type="GeneID" id="119723813"/>
    <dbReference type="OMA" id="HLPFNQS"/>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745:SF1">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="17923" checksum="FAA4D5B7016D3CC9" modified="2023-02-22" version="1">MDLVKSHLLFAVREEVEVLKEQIKELLEKNEQLQRENNVLRQKQSQGLPTHLPFNQSEAAQPNLQHVGGPSASQDKGGFQSIPGPAAPRVDGYQQQPGTGEQFASMPAGAGPQHGQAPGQQQQVLPQQQASQYGHLQQQAQPKQQQQHTQQTSNQVNQTPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGG1</accession>
    <name>A0A913ZGG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050882.1">
        <property type="nucleotide sequence ID" value="XM_038194954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194954.1">
        <property type="protein sequence ID" value="XP_038050882.1"/>
        <property type="gene ID" value="LOC119724033"/>
    </dbReference>
    <dbReference type="GeneID" id="119724033"/>
    <dbReference type="OMA" id="SSRCEME"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="815" mass="90781" checksum="81878AA5D4C544A7" modified="2023-02-22" version="1">IAYAHTALNYILDINYHLGFATRRVRTYVRISHVTRRLHSASALGCNASCQSKQPPTQLSCADFHRLPLRQPAHIGFTLATRYSCWSSFIKSFSYAEPGQVIYIYWGSLPGLPNIDRHPEPVELARISRQTLKQSFYETPVPARAMKDTFHPSYPSNMYSSSKAMEACVSPTSTPTKIQWIKTPCIRPSQGLPAQDNLTKPDWQPPVKGPGIIQIGDAPSDVQGATEPEGVAIPVANVVGCASDLLEKRSVCDIKAAHGVIATAPQTSLAGCSGVSQEDCRYQKSPDSEHVLKQFWPHSVSETVRSGTKKYLSEETKILSHQLQPPLNNKCNTDMSLPKEETNSVHITFHKNHKPILPGTSVDPIHKPWKAEGTVTGAGVCQTRHSNLSDIERQRGPIKKRHINFQSDALDLSTKKAKVERVMSPEGLEVSPDGSCIKMQSISSHQVLMDHEGISVTLKQEPHLTNTAATKQETSLPQANKFMPTPDARDRKRNMTGNISNLDQKQLLTNPTAISGNQLEWQSYEISENDNAYSARNLVPVLPSQEFVRQWVMHVTQSSDVFATQNLKAKVSQDAELRHSPTSVASYQGSVSSSPTFHNPGRASTLSTSTVTKMVKPYACEHCSSTFKHRHHVVRHMRAHSGERPFRCDHCSATFARKCVLTNHRRTHTGEKPYICSECGDTFSRKHHLVIHQRTHSGEKPYRCRDCGAAFARSHHVNRHRKTHEKEAEVDAQIQWLESNVRGLNHTLPTMVSLGHSGASLDHDLESKPSLSHEVTPPVVKTTVEMIKSHKVQHTESTVSTHKDEIMVNSVTYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGR1</accession>
    <name>A0A913ZGR1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050205.1">
        <property type="nucleotide sequence ID" value="XM_038194277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194277.1">
        <property type="protein sequence ID" value="XP_038050205.1"/>
        <property type="gene ID" value="LOC119723561"/>
    </dbReference>
    <dbReference type="GeneID" id="119723561"/>
    <dbReference type="OMA" id="THVARIN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF32">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765262" description="Alpha/beta hydrolase fold-3 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="107"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="314"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="403" mass="45197" checksum="EBC5BF112116FEEE" modified="2023-02-22" version="1">MVHVRGILLAFVVAVVAVTTYVVLEPIPEDVDSPWMLKIISKFLILSPYGMKALPTGLVDWLDERFRAHSRASEPRVPYRDAVFDRVPVRIFADEPAGEKTDKRPAIVFYHGGGFVSSSVDMHHSLTAMLARELNAVVVSVDYRLAPKYPFPAAIDDCTAATVWFLKHIGDFNVDPGRVAIMGDSAGGNLAAATAQRLTFDPEYRDLPRPKLQVLIVPCLQAFDFHTPSYQQNGKYNTLILRRITMATYWNKYLLGNKGDVTEAMVINNHTSAAAKSSPLVQKCLSRDLIPDEFKRPDYRAPSTDFGDDALYEEIKDVLLDPDYAPLMREDLRGLPEAYILTAEYDVLRDDGIMYAKRLEKAGVPVTWKHYKTGFHALFGNLIPSEVGKQGDKDFLQFALKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHN4</accession>
    <name>A0A913ZHN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050904.1">
        <property type="nucleotide sequence ID" value="XM_038194976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194976.1">
        <property type="protein sequence ID" value="XP_038050904.1"/>
        <property type="gene ID" value="LOC119724057"/>
    </dbReference>
    <dbReference type="GeneID" id="119724057"/>
    <dbReference type="OMA" id="IWKLTVL"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="455" mass="49040" checksum="1F49D743A981C4DD" modified="2023-02-22" version="1">MNSPRSPMQTREKKTPKSREGGWGIVVVIASCSINALALGLLRCGGVLYQSWMDEFETGAKEIAAIQSILSATPCFSGLVGAVLCKRFGCRFSGILGGVLWFLGLFCSYWVQNIFQLYVTFAIAGAGVGISYNFGLVAVAMHFKKRYKTANAVALSGSGIGIMAAPPIAQLLLDNYGWRGTLFIISAIMANSIACGALYRPRRNVQRSPKELQLNSEDHEQESRIGEVRPESPTNATDASGNEPVIFQTSTVAMRSCNDDPDEICYISVDQSSKREYASFKDERKQNQAGSLLRRFCSELSIRVLMKNYRFLLLCLLSVEFAPSYLSFPLFVIPRAQSIDVAPSSAAFLVSILGIGTLLGQLGNGLMLSCRTSAEHVLAICVALSGVSLLVLNVDGYVYLAIASFLQGFASGAFFATSFVLILRYVGLEGFAVGTGWHTISSGVGQLLGPIVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIH6</accession>
    <name>A0A913ZIH6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050856.1">
        <property type="nucleotide sequence ID" value="XM_038194928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194928.1">
        <property type="protein sequence ID" value="XP_038050856.1"/>
        <property type="gene ID" value="LOC119724008"/>
    </dbReference>
    <dbReference type="GeneID" id="119724008"/>
    <dbReference type="OMA" id="ATVTECA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="468" mass="46894" checksum="36EA88AAD06E29F0" modified="2023-02-22" version="1">MVYTSQKSPCTVDLVIKVSKGLAAGASEALALVAAASEALAWRLGLWRLRFWRLWSITSASSTSTTTSSSTTSTSSSTTSSSTASTSTTTSTTASSTRSITSTTSTSSSTTSSSTASTSTTASSTSSTRSITSTTSSSTSTTSTPLLHQVCYLHLHHRLLLLHHRHHLHLLPSSTRSVTTSTRSISSTSTATTSTSSTTTSTTTSSTRSISSTRSISSTSSSTATTSTSSTTTSTTTSSTRSISSTRSISSTASTSSTTTSTTTSSTRSISSTRSISSTSSSTATTSTSPASSSSSSTSTTTSSTRSISSTRSISSTSSSTATTSTSPTSTTTSSTRSISSTRSISSTRSISSTSSSTATTSTSPTSTSSSSTSTTTSSTRSISSTRSISSTSSSTATTSTSPTSTTTSSTRSISSTRSISSTSSSTATTSTSPTSTTTSSTRSISSTRSISSTSSSTATTSTSSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKQ5</accession>
    <name>A0A913ZKQ5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052387.1">
        <property type="nucleotide sequence ID" value="XM_038196459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196459.1">
        <property type="protein sequence ID" value="XP_038052387.1"/>
        <property type="gene ID" value="LOC119725096"/>
    </dbReference>
    <dbReference type="GeneID" id="119725096"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="645" mass="72466" checksum="AE6AFEFB546AE380" modified="2023-02-22" version="1">MAEAAAKTVLDKISQGHLECPICCCRFKDPKMLDCLHSFCLNCLEEMMNKKKSETEKITCPVCRSETQVPDKGLLNLSSSFVLSSLVDEVKQQETLLGKVSRPTATCDCGDDRKATWRCLDCSDNLCQKCREAHVRVKYTKNHQIISFEDWHKSVIPGPKADHVKPITRMCTNHTDQALCFYCDTCDTFICIVCVAIDHRSAEHSYKKIDDSVRSFRRHVDDALLQFEKCKLRVKSTINSIKHARNRLQNKLAQARSDISAKAEAEIAKIRNKAKLLTEKVDQIGQERDSEYKKALMHNCDQVKRADQIVTAVNDLMKQADDFELLELKAKVANNLEFQKELNLCEPAKLDMAFIGVKCQDVVGNKDLGEVRISEKWQLKEEFGEEGTDDEEFQFARGVTCFSNGDIVVCDFNLERVSLFSANGRYKLSIAQGSDSNQLESPAAVAVNCDDMLFVADQSKVKVFDTELQFVREFTPSVDDAEGPFEIDIDCIAVDKQRVAVADFDRNVISVHNLDGSLIASTSNIMVRFFIAMSNKEQLIFTNYVEKRLLCVDLRGNEVFNVMPLLKGKPAKPTGVLCDDDGSIYVAVHAESGEFGDGEVQHYDSNGAFIKTVRQGLDFPLGMAFTPVGDIVVAEKHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKX4</accession>
    <name>A0A913ZKX4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038051740.1">
        <property type="nucleotide sequence ID" value="XM_038195812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195812.1">
        <property type="protein sequence ID" value="XP_038051740.1"/>
        <property type="gene ID" value="LOC119724659"/>
    </dbReference>
    <dbReference type="GeneID" id="119724659"/>
    <dbReference type="CTD" id="8798"/>
    <dbReference type="OMA" id="HRRSFHT"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14225">
        <property type="entry name" value="PKc_DYRK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="264"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="572"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="760" mass="86830" checksum="DCA9381D94A39FBB" modified="2023-02-22" version="1">MNRKLRVYVPSVSQNPGTDEAKKTPGKFSLDSLTRRSKNVSSSLLPQRLVKRSNLSKGTEPQTSPEHEPTNLPGRDTKGHLAADTMKYGSSKNQPLQINGMVGRKTSGTHGEKLTSSSLPPAMTMSNTSFPQLSLGPRGISNVETLPQLSNLHGNLVSTHTASEQARLHRQKTHIDRDQGKSDSPKKDAMGHRLPLTPGEALKFYRDRLTAYEQSEILDHTDIWFLGAEAKKIEGVQGAAQNNGYDDENGSYTKVLHDHLTYRYEILEVIGKGSFGQVVRAMDYKTGDIVAIKIIRNKKRFHHQALIEVKILDALRRKDKDNSNNVIHMLEYFYFRNHLCITFELLGMNLYELIKKNNFQGFSIALIRRFAYALLGCLKLLHQERIIHCDLKPENILLKQKYQNSIKVIDFGSSCYVNQRVYTYIQSRFYRSPEVILGLPYGMPIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGMPPSNIIDEAQRRRLFFDSKGNPRCITNSKGKKRRPNSKDLSYAIKTNNTLFLDFIERCLAWDPSQRMTPDEALQHEWVQEDKLYKSHARELTQQQITRTSTTKPKHHYHHHRHPHHHHHHHQPKAETEQQSGEPDPVAAASHQHQEVQQQLQQQHKNEEGVQQRHAKASKHQVQNNSDSETVHRGKETLERKVSMKKKSAKAKESSHINPPKEAHQLTETTEKPVNKVKPLVVDADEFLEKAPSITTEDLKDSVKDCKERDSEKTEDLPTKQFLPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL27</accession>
    <name>A0A913ZL27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051751.1">
        <property type="nucleotide sequence ID" value="XM_038195823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195823.1">
        <property type="protein sequence ID" value="XP_038051751.1"/>
        <property type="gene ID" value="LOC119724667"/>
    </dbReference>
    <dbReference type="GeneID" id="119724667"/>
    <dbReference type="OMA" id="QEVDHHK"/>
    <dbReference type="OrthoDB" id="10045676at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="118" mass="13013" checksum="C0A9C12C567927AD" modified="2023-02-22" version="1">MALARVSTIRLFRPIAAMCQLQRGYAGEHGSGVGKGGGAGGTIRDAGGAFGKMEAAHEEQFFRQLQAEQLKALKKHHDEEIEAHEREINRHSEEIQRLKKRRKEIDASRGEGSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLD6</accession>
    <name>A0A913ZLD6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038052618.1">
        <property type="nucleotide sequence ID" value="XM_038196690.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052620.1">
        <property type="nucleotide sequence ID" value="XM_038196692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLD6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196690.1">
        <property type="protein sequence ID" value="XP_038052618.1"/>
        <property type="gene ID" value="LOC119725309"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196692.1">
        <property type="protein sequence ID" value="XP_038052620.1"/>
        <property type="gene ID" value="LOC119725311"/>
    </dbReference>
    <dbReference type="GeneID" id="119725309"/>
    <dbReference type="GeneID" id="119725311"/>
    <dbReference type="OMA" id="WTENTAI"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="298" mass="34326" checksum="FA8F9D74DD1A1706" modified="2023-02-22" version="1">MAYNLSSTEVTQFLECVLQIQSPMESLARDRVSFLRDLIAAFLSKIPYQSVTSIATPKPERRRLTFQEIKFDMMTRRGGLCYEMNSFMKLLLEKLGFEVYHIGCTSFGKTNNHLAIVVKNLSRPGDLHLVDVGCGHPTFELVPLDFDKESPLYKTSFLVHKFVKDADGSFRWMHKSYRDFDGPSVIVVDGWYMFMKFKLEFRDIEFFFPHMEIVHTVEIGPEALSIMLVQLKAVDYRNGKLLAITGTSNLEEDASGKVNKKRITSPQELLEAYRVHFPQFPVETVQQAIQTVNLKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLE5</accession>
    <name>A0A913ZLE5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051918.1">
        <property type="nucleotide sequence ID" value="XM_038195990.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051919.1">
        <property type="nucleotide sequence ID" value="XM_038195991.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051920.1">
        <property type="nucleotide sequence ID" value="XM_038195992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195990.1">
        <property type="protein sequence ID" value="XP_038051918.1"/>
        <property type="gene ID" value="LOC119724779"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195991.1">
        <property type="protein sequence ID" value="XP_038051919.1"/>
        <property type="gene ID" value="LOC119724779"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195992.1">
        <property type="protein sequence ID" value="XP_038051920.1"/>
        <property type="gene ID" value="LOC119724779"/>
    </dbReference>
    <dbReference type="GeneID" id="119724779"/>
    <dbReference type="OMA" id="EGIMKEE"/>
    <dbReference type="OrthoDB" id="9970438at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275624" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="115" mass="12912" checksum="0B609050177670F1" modified="2023-02-22" version="1">MRTGLFLLMVVTFTVTMTTAIDLNPSMIATVTRIVNTLANEEGQVTVAGRVIKYKAKGRVHSFKEPWVYDGTAWDITSGISEKANHYKSKQGAIEHAMLKLLERLKREGIMKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM84</accession>
    <name>A0A913ZM84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052913.1">
        <property type="nucleotide sequence ID" value="XM_038196985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196985.1">
        <property type="protein sequence ID" value="XP_038052913.1"/>
        <property type="gene ID" value="LOC119725551"/>
    </dbReference>
    <dbReference type="GeneID" id="119725551"/>
    <dbReference type="OMA" id="EMMSKQV"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="11">
        <location>
            <begin position="419"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="626" mass="61454" checksum="C083DA32319190EF" modified="2023-02-22" version="1">MIESVVFSVKSTMANPPNNLFGTPASSGTGGGFSFGSATPGGTSGFSFGTAKPATAAASTTSGLGTGGFSFGGGGTTLGSASGGLSFGSGTPSTTATAAPAGGGGFSFAGAQPAAASTTNAASTGGFSLGAGVKPVGSNFSFGATPAASTAAPTLGGAPANTGGFSLGTGATAATTAAAGGFSFGATPSATPAATLSLGGTPTLGGTPTLSGAPAATTTATGGFGFGGGSTLGGGASGGFSLGGATPASSTSGGFSLGAGLGASKPVGFGTPVVSTTTTAATAAAASVTTNQGFSFGAKTATATTAVSALGSTTAPALGSGTLGTLGTLGTLGTPSTTTSITGGGLPFGATATKPSEGLGSLLGKPATTSTTGPVSAGLSLSLPAATSIATTTSSTTGLSLGGLGGLTASKAPTTTTTTTTAAPSTQGPTLSYHQLEQAINKWTVQLEDQEKIFLTQATQVNAWDRILIHNGEMITTLHSDLEKVKTDQQRLEHELDFIMAQQRELEDMLVPLEDAVRTQQQGTVYSQHADSERERTYVLAENIDGQMKRMVQDLREIIEHLNTANAPQDTNDPITQIGKILNAHMDSLQWIDQNTVMLQRKVDEVTKQSEIVRRDQEKNVHLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMZ4</accession>
    <name>A0A913ZMZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053167.1">
        <property type="nucleotide sequence ID" value="XM_038197239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053168.1">
        <property type="nucleotide sequence ID" value="XM_038197240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197239.1">
        <property type="protein sequence ID" value="XP_038053167.1"/>
        <property type="gene ID" value="LOC119725706"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197240.1">
        <property type="protein sequence ID" value="XP_038053168.1"/>
        <property type="gene ID" value="LOC119725706"/>
    </dbReference>
    <dbReference type="GeneID" id="119725706"/>
    <dbReference type="OMA" id="FHNERAG"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="4">
        <location>
            <begin position="228"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="480" mass="55827" checksum="380B7FA2D818B685" modified="2023-02-22" version="1">MATASEIAAAKNALIQSTAGAVPFMNEKGEMSMQKVKVKRYVTGKRPDYAPDSSSDEEETLEVAFVRKSKTTAGVPSSKEPDEEVDSRLRRLREREQEVEGDVVERIARHRRVLGPEVLDEGELEPEDEDDADEESDDSDRDYASRRQMHVVHRMEAEESSSDEEEELDEEEIERRRAMMRERAQGRGGPKEDEELLGVEDDEDVAEKEAVGDEDEEEDSEYEEYTDSEEESGPRLKPVFVARKDRVTVQEKEMEVQKEREIEEMNKLKIEERRKETLRLVEKTNRQELELQAESSVKDANLASVNTDDENDEEEYETWQIRELKRIKRDREQREQIQKELAEAERLRNMTEEERRNELRVNPKVVTNKAVKGRYKFLQRYYHRGVFFMDEEDQIMQRDVAKPTLEDHFDKTVLPKVMQVKNFGRSGRTKYTHLVDQDTTEVDAPWMQDSAIGRKFQANAAGGMKQSFEKPTSSRKAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPQ0</accession>
    <name>A0A913ZPQ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053697.1">
        <property type="nucleotide sequence ID" value="XM_038197769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPQ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197769.1">
        <property type="protein sequence ID" value="XP_038053697.1"/>
        <property type="gene ID" value="LOC119726158"/>
    </dbReference>
    <dbReference type="GeneID" id="119726158"/>
    <dbReference type="OMA" id="CINIYNV"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="64651" checksum="A92F261084E9163A" modified="2023-02-22" version="1">GQGSEIKCQACDEENQALSRCTDCDQFLCQECQKAHGRMTVMKSHKIYTLAELRSGEIVYKSKLRDEVPKCGKHPDQNLNVYCDTCEQVICLMCTVLDHGNPKHSLIGLSEAFGKCKNKVEELVSEVTKSKTELNTTIEKTCTSRKKLDIMFENTKKKISEKADQEVAKIRQEEQTLLTETDRIYQERVTTFEAAQANNSKAMTQTKHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDKLTFMDFEEGERSLGRLILKEEPKAAAKQSLRPARSCVMEKRELKTEEQSRGAAKQSPRLARSCVKEKWELKTEFKNFEVGNTQIRHVSALSDNNIVLTNWNNTLFTVSLTNSQHTPSPITQRLQINGLTDARCIAVSKDDKLLALDGAVVKVFNKQHQLLHQFTPGIGSGNHPTCLAVDDSNLIAVGYEVKNEISLHNPDGSLIRRLPAPMIGGYLTMYNHRLIYTNYGSRRLVCVDYYGASVFPVDMTSNMQGRGCYPTGVCCGSDGSIYVAVYGYLTGNILHYSPDGKYIGCVIKGCGYPRGISFTSGGDLVVAEDQSVKVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPU7</accession>
    <name>A0A913ZPU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_038053803.1">
        <property type="nucleotide sequence ID" value="XM_038197875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197875.1">
        <property type="protein sequence ID" value="XP_038053803.1"/>
        <property type="gene ID" value="LOC119726250"/>
    </dbReference>
    <dbReference type="GeneID" id="119726250"/>
    <dbReference type="OMA" id="RRCNYVR"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038172680" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="34324" checksum="D29F2FA47EC834B9" modified="2023-02-22" version="1">METRASTCMCVVVCVAALLSIAAAAGWDYLDGAKGPSTWATNYETCGGMKQSPIDIVTSKVVDEDLGDFTFVGFGEDDEPVDAEMTLENNGHSIVVGVTGDYQVSGAGLGTTAYKVVQFHFHWGSVNSQGSEHTIDGKAYPGELHVVCFNTKYADFVTALNEPDGLTVLGFFLDVQAADNSVLAPLFDLLSMIRFEHEEEDLSTPVVFKNFFPADLSSYYRYSGSLTTPPCYEIVTWNVFTEPIMVSEAQLMLFRRQFANEQDAPANISLVDTFRPVEPVNDRTIYMNSGTAALVASYSLIAMVLVKVLASVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTL8</accession>
    <name>A0A913ZTL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054545.1">
        <property type="nucleotide sequence ID" value="XM_038198617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198617.1">
        <property type="protein sequence ID" value="XP_038054545.1"/>
        <property type="gene ID" value="LOC119726774"/>
    </dbReference>
    <dbReference type="GeneID" id="119726774"/>
    <dbReference type="OMA" id="DQALVHI"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22125">
        <property type="entry name" value="F-box_FBXL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000051">
        <property type="entry name" value="F-box and leucine-rich repeat protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000059">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047932">
        <property type="entry name" value="FBXL14_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF76">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="454" mass="50424" checksum="F1382B31BA251B9E" modified="2023-02-22" version="1">MQWPCIGQACMAVECSYNPWCMYTPYTCPCCQPKIDVYCYQSRAKRRRCVTPKAHQSDMSGEAHISCLFPEILALIFSYLDVKDKGRVAKVCRSWRDASYHRSVWRGVEAKLHIRRTNPSLFPSLVARGIRRVQILSLRRSLSHVLQGMPHIQSLNLSGCYNLTDFGLSHAFVHEIPTLTVLNLSLCKQITDTSLWRIAQYLKNLESLDLAGCCNINNTGLLVIARGLPKLKCLNLRSCRHVSDVGIGYLAGMSSEAAKGVCNLEELVLQDCQKITDSALSNVAQGLPQLRSLNLSFCCGVTDSGMVNLSRMPSLRELNLRSCDNISDIGIAHLAECGGHFTTLDVSFCDKIGDAALTHISQGMYNLTNISLSSCHVTDDGLDRLVRNLHGLTTLNIGQCVKVTDRGLKLIGDHLHKLKCIDLYGCTKITTVGLERIMQLPCLSVLNLGLWHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWC1</accession>
    <name>A0A913ZWC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055819.1">
        <property type="nucleotide sequence ID" value="XM_038199891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199891.1">
        <property type="protein sequence ID" value="XP_038055819.1"/>
        <property type="gene ID" value="LOC119727822"/>
    </dbReference>
    <dbReference type="GeneID" id="119727822"/>
    <dbReference type="OMA" id="FPIFRIA"/>
    <dbReference type="OrthoDB" id="5982567at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="252" mass="28846" checksum="9FC9940619613F5B" modified="2023-02-22" version="1">MTTADNRISTMANNADPAMHQLHVLDGAKTWYLDGTFKLVKRPFTQLFSVHAFVKGDTGGMKQVPLTFVLITRRTKKDYKKVLKALRRKLPSRAANLQELVVDFKVGLWGAIRAVFPDASVNCRLFHWTQAVWRKCQALDLAVPYMSNDGVRDFIGQLLSLPFLPNEHIGPAFKELSSLVTDQPAMVELCSYPRTTWLENSTWSPRDWNQRRMYMYQQVQGKIFKLWDDYQARRLTTSGLLAACKYLTGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWG3</accession>
    <name>A0A913ZWG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C17orf113 probable zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055857.1">
        <property type="nucleotide sequence ID" value="XM_038199929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199929.1">
        <property type="protein sequence ID" value="XP_038055857.1"/>
        <property type="gene ID" value="LOC119727856"/>
    </dbReference>
    <dbReference type="GeneID" id="119727856"/>
    <dbReference type="OMA" id="HANSENH"/>
    <dbReference type="OrthoDB" id="6159421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C17orf113 probable zinc finger" evidence="2">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="268" mass="30498" checksum="CD620DB579FDB51C" modified="2023-02-22" version="1">MKELVNSSCSESPSKKKKDVGKHRVSGFDPKWMETFQWLLRTSAGMVCTVCRKHLVGAARAHPFVNEPSINYRLDAVSRHEKSSSHISCIEKEQTLRTGKTLPKIVCERADIEHWALEGCFRLMYQMLRQEVPHHTNYKGFLELMEDCGCKYFEALRVDSNTNYCSHRIIDELLAIINDSVLQPLLIDLQKSRAWSILIDESTDISVTQELAICVMFLNQHSKVETTFLDMVPVTNGKGETVTDAILQLLQRHDLSMKNLRSIASDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX04</accession>
    <name>A0A913ZX04_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the IFIT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056077.1">
        <property type="nucleotide sequence ID" value="XM_038200149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200149.1">
        <property type="protein sequence ID" value="XP_038056077.1"/>
        <property type="gene ID" value="LOC119728075"/>
    </dbReference>
    <dbReference type="GeneID" id="119728075"/>
    <dbReference type="OMA" id="NFFFDAM"/>
    <dbReference type="OrthoDB" id="10043504at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271:SF0">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1132" mass="131197" checksum="15C1E4C8B9A3F27C" modified="2023-02-22" version="1">MTGNEERMLPWKDRPLCHFTWNLKVAVTTDYERIIRNIDHDLEETPNVLRIESLLFRAYLEVWDNRKRWDVRKAREFLDRADECIERTDVQLRKGYRVVALLNRMWIEYKCHNTQKVTDLLNELNSVRLRDKDHSVVGAVRAAALTRLGPHVKETALQLFEVALQSFPKNVDFIYGAGLMTGRMARYRRSGSSLYKKLDKEGQRLMDNEKEYWLKMMRKNDEYQLARSSLGLNLSRRGKKDRKKGCQHLTKAYEKNPEVQEVVRNLARFYKGTREFEEAIPLLKNGIERSPDCPESHFQLALCYIACSKRDKAIQEKKDEWNKEALEELHKCLDLNKGHNFALTKLCNVHAALGNHEEAEKIYETGLQQSEHRTSEDKLDLYFRYAKFLHYTPAASRHDSRMDMWHTVMDIAASFEYLDEASGTWQVSEKAKWPKELAHEKLLEYYVSQNNSCLEVGILHFQNFNFKEAERLLVQHDTEANFKITWYLAQTYLKMGLEEELQALSQNIGPDEAKETFRKAHENALRAMEVGLNQGESRKLLADIALAIAHNEFQLLNLQQPTLASIPLESRCIMFYRKAVRCGSLVASLELLRLIQKDSLQITSRWIFLQILAEIDVSCSLRSSNFLHQEENPLSFGEGLSSRDRDKDASALNCKTIKRDVMAILHQEPFFRQAWREHFNMEREILLHRFENNEGELELDGREEEKKDTFSDEIVHAATDCCEKLRPLLDRIVVRFGKEELGLGEMRGQYFPLILDERNAANIQDKFRRNVIATFGIDMKKHYPKLYEQLLMTQPGCSSQNGFLKTFCTLVNKIKHSDVHLNDILQTSKDPVALARQCTDKVEEICNFFFVAMKKSRDLQTKVKQLEDDIRRGEHETADELLQVLSNNEDFVVRIGSTWTLLEMMALIRTSRRLSSPRDVETDELESKLTDGGCTFTQKLRRCHQTVEDALLHRNNEVRTKCRDTCREAVKLLNSVLAKHKNEVGNCGAAANLKPNSPKVSRRAQKVTEERPIAFPFLDMCPDDESRQQNEPGHWKGVVKKQLEKNLSKMGVDKKLVDIILKAQPCVSEENYNFIAMETFLQGGGDDVIVRITTCNGEEKSFQVLDLTRWCTDNAERLALEMATIIPSLVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXR5</accession>
    <name>A0A913ZXR5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056105.1">
        <property type="nucleotide sequence ID" value="XM_038200177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXR5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200177.1">
        <property type="protein sequence ID" value="XP_038056105.1"/>
        <property type="gene ID" value="LOC119728104"/>
    </dbReference>
    <dbReference type="GeneID" id="119728104"/>
    <dbReference type="OMA" id="CCAGSKY"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="236" mass="24713" checksum="59A5931FDC87797A" modified="2023-02-22" version="1">MQPVAPIQSVQMQMPPTAPSRRSRYSCAVKSLGVLQIILSGVSAIVGVVAGFTGSVIGLAFAGTWGAILFFLPAGILGVLSVTLAVGSRRCLAIACMVMCILASVMAAANIGQYGASMAFDGYYYGGGGYYYYTPVPIAMDGILVVVSLTELVVSITASVYCCYVMSEYRPTNPTIQFISTQGNPNMMAYNQPAVAYNQPAVPYTVTPAAPGTFVANQPYTQPPSYTACTTQPGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A160</accession>
    <name>A0A914A160_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosome-associated FAM110 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057384.1">
        <property type="nucleotide sequence ID" value="XM_038201456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A160"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201456.1">
        <property type="protein sequence ID" value="XP_038057384.1"/>
        <property type="gene ID" value="LOC119728980"/>
    </dbReference>
    <dbReference type="GeneID" id="119728980"/>
    <dbReference type="OMA" id="RVIKWLC"/>
    <dbReference type="OrthoDB" id="10028183at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025741">
        <property type="entry name" value="FAM110_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14160">
        <property type="entry name" value="FAM110_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosome-associated FAM110 C-terminal" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1164" mass="129845" checksum="C443F8523CCEDBA0" modified="2023-02-22" version="1">MAVTSESSAVTNFPLRTFNSGPGFRRDASARDQQPTKKSATERLTETRSKYVRRGSREELEDKGEENRTHSDTHRVHQVPLSHEETQGHLFRAVPYVQDGGRSPAQKSHARLPPPVPEKPSQRNRKGSRDRTLEIVEASLGHSVRRSSNDVPVSPRGAVVSTDFSNPSSPSAGSRVRRLKEQFLNFGSAESGSESSQGPVSPTELLKSSSSSDSALIWKKRSVPSNPQDAQASDFQAPSEVDALKSKEVLQRPSRTLSEKPNLLERSKVEAADPSENPGTASEEDHDPTEESGMKSKPQQASATSSEGLSDQTRRQMERFKARYATDFAKESSQGRKISRITLKPTNHEAESKERSSSVNYGPSHKLSYGVVRPRSNISKEESPGQTSQVASKPDLFSRPRAPVNIPPVSDGNENSTEEIKQNGMSQKLNLASHHDGNFRTGRLDPDISKPMTSDDIRRLRRTKEYNISGKSPERWGDAEETSKSQGSVLEHAVHHAGDRVLVQVGGSVFPSKYHVSDEAFRSMLQPPDTRHEDSSVEVIHRRAKSDLDQHNPALGAPNMPKEDANSNRMRHHSQGDQLQHDPLFPTSARKTSAQSVLFKHAKTSPDNIKNFKEKSWAPVNFSQNQNTNDAHKQGAQEGLVQNRRALSPDTSRTRTTATELQNPQTHIHVLQQHTPRKISQEDSHEHAKSTVQSFLSGIMTSPGGGEIHDSPRTLYNDGNGNHIALEFSDNETHTSGTHWARPANGSDDANSNIQNNNRARVSVSKDVELTAVWEKREPSMTPTGKETSGKMEHRRKYLGPSMEGERTDELDKRRKFSHNSDTSSSNQDRGHLGFKVAGWSSVEPQRVKKVSLADLLSKDTTQEKTEATKSNQEGNSKWVAPPKPYESNRDDSETDSDVEHRQTKILRVKKPPRHANQKKEDKSLENLLSRIINPDDELNTLKRGTKVKARENPKAKVSRTSSKNNCGSSTAESDNEAKKEKDLAIKKSLPKRDIPHFQASAEVRKPLHNRNRNAKPVNREDAVSPPESLTSPTRRDFRRRRSKSDLGVSPRCSVSSAHSDVERFFNQMGLNESFFQGPLSPMPYSDEEEVFHEMHEYKHVRDDDDGTFSTENSDNISRGSKVSEEGLRRAKKLPDTSQSIITKNARVIKWLCQMRKARAASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A394</accession>
    <name>A0A914A394_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038058140.1">
        <property type="nucleotide sequence ID" value="XM_038202212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A394"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202212.1">
        <property type="protein sequence ID" value="XP_038058140.1"/>
        <property type="gene ID" value="LOC119729591"/>
    </dbReference>
    <dbReference type="GeneID" id="119729591"/>
    <dbReference type="OMA" id="RDAYKHE"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000018">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="621"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="697"/>
            <end position="701"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="960" mass="109423" checksum="0BEC05E770BBCEF3" modified="2023-02-22" version="1">MSAYRCLDVPVHFLRTAWTGLLWLVYGTEEEDEEETVNSMSATSPTPKQVEVWLQENQEWFEDYFLKNGSKKLVQRWIESHKGEMIGSGPNNFGLKPALSPSTQRRVTYAQLSNSKSRTNSQSDEKTDNNNEEANPIRPRSGSRQYLRQDFAKARSRTLFNTWASPSPACTDNDDPDQDSGPTSPRDPSNCRRGQLRRASTVPPERHSISMLSLLLEPKVRLPHRTSITNEAKLELRSTDERQFFLALVKDISQDLNLDSLREKISTNVGILVNSERTSLFLLEGPKGREMLVSKPHRFASEIRESNNGSKGISQWQERGVMLSPGEGFVGRVAETGQTLRIESPGEVPKDVETLIGLQVRSVLCLPIRNSDDDIIGVCQVTNKVSGSRFTEHDEKLIETYLTFCGIGINNAQLFDTYMKEYDRNRKLLEVAHDLFEEQTCLDNVVQKIMQRAQSLLKCERCSVMLVKDPTAETITFSKVFDLPSTLHNGHSNNPVCCTGDVKLSNGIIEHVASTGDTLNIYDAQNDPRFDKELDKATGFHTRSILCMPVRDNKYQIIGVAQILNRTDGFPFDENDEQLFEAFTIFCGLGINNTLMYNEVEKAMARQKVALEVLSYHACSTSQEVDVLKISRLPQIQALGMTRFDFDDFKLDADEMVKASLRLYMDLGLLQKFKIDPEAMTRFLLTVRKNYRPVAYHNFRHAFNVQQAMFAVLQNTSVVHYLTEPEQLSLLVGCLCHDLDHRGTNNAFQEKSQSPLSQLYGSKATMEYHHFNHTVMILSSQGHNIFGNMPAEQYSEVMNVLKHAILATDLALHFKVRSQFFDLVRGGRQNWRTSQHKELLRGMLMTACDVAASTKPWRIQHKIAELVTSEFFDQGDKERNELKIEPTTMFDRNRKDELPQMQLGFIDGVCLPLYESLVKVSPMFTTMLEGVRSNRKRWNELNEQRKRKKSTSEISKLNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3C2</accession>
    <name>A0A914A3C2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058170.1">
        <property type="nucleotide sequence ID" value="XM_038202242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3C2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202242.1">
        <property type="protein sequence ID" value="XP_038058170.1"/>
        <property type="gene ID" value="LOC119729606"/>
    </dbReference>
    <dbReference type="GeneID" id="119729606"/>
    <dbReference type="OMA" id="LFNHGDP"/>
    <dbReference type="OrthoDB" id="10039716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14813">
        <property type="entry name" value="bZIP_BmCbz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF20">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="34845" checksum="767CC3AF55BA2390" modified="2023-02-22" version="1">MACRGIEEEETVGSRGPVVNPVEIISTGLSKDTSVIFGHQAPGTAQRASMPMSSLFNHGDPDLSFCDVLAAYPIETESDQPPTVDVEGFTDLMLFPDLMGVLEENLPGSFQDLPLDPMGGVGEPFKPRDVISSVSDGGEISPAESDASVDHFFNTFTDLTGFLQQLTEETGPTDLNDLATSIAGSNDPLMTDAEPSAMATTTLPTPVGSETACKEEECSPRRPAPSSDDDDDDDEAPPTKKARTSRHNASAKSAKQKYRQRRDKNNIASQRSRATRKQREGEMVVKAKELEAENARLRVRIDELTVIAEEARKCLVVSLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4G7</accession>
    <name>A0A914A4G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058590.1">
        <property type="nucleotide sequence ID" value="XM_038202662.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202662.1">
        <property type="protein sequence ID" value="XP_038058590.1"/>
        <property type="gene ID" value="LOC119729872"/>
    </dbReference>
    <dbReference type="GeneID" id="119729872"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1402"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="15">
        <location>
            <begin position="560"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="759"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="797"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="861"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="899"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="936"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="973"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1050"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1088"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1126"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1201"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1570" mass="171126" checksum="A765EDACAE27C78C" modified="2023-02-22" version="1">MSTNKITIKWVNEKWDGLVEDVVRSRVKSRDPLEIGMEVQVTYRSSSHRAVIVGIGDKKRKLSEDSDEDDVPLAVVKRLAAGPSTLPEAQLTGEPTGPASDLKAQPVPIDDPTGPTSDEAQPIPIDDPTGPTGDEAQPIPIDDPTGDEAQPIPIDDPTGPTSDEAQPIPIDDPTGDEAQPIPIDDPTGPTSDEAQPVPIDDPTDPTSDEAQPVPIDDPTSDEAQPVPIDDPTGDEAQPMPIDDPPSVPEAESTISQLQYDLIPDFDLSVITGVVPKTLDEQSTQTKELRGEMRDLQAEVKELRAEVRELRSDEKNASTRSTSERREPQYVIDDKQPNTVHIGLNTGHCDSPASKKHSVGCALRCSASVDSRHSKQPLAIREDLLGADDNKFGSLPSKDSVFLLVWANATVQFKFVSFYNSDHNDYDRGCCDDFFGGCDDFCDNYFFVCIDGDDTGPLGTSCDMAAITTAKLHEDNDNFNFPSTIPNLIANPYTMRVTSWSDSMQVFVRVWDLDTQNNDDEIDRARRTIYKEAARSLSTATWQQYRLGSRSQIDFIFEVRVYCDSYYHGSDCSVHCIPRDDQYGHYRCDALTGDKICYSGWKGSNCELDYDECQSNPCANGACVNGVDRFSCSCTIGWTGPTCDINVDDCASMPCKNGGTCHDHVANFTCACPLGEVYADEFCEYDDCAGQPCQNGATCNDLIGQFKCVCPLGYFGDLCEVDIDYCINQTCANNGTCVDRVGGFHCLCETGYEGLLCDVETDECSSNPCLHNGTCHDLIGKYQCACLEEYEGTHCDLETDECLSSPCRNNATCEDEFAGYHCHCVDGYEGDTCEMDIDECASFPCYINETCVDEINGFWCQRLNLCDNDPCLNNATCVDVYPGFICECVAGYGGKTCDQDIDECASSPCLRGTCTDHLDGYTCLCPPGYGGEKCHSETNECNSSPCLNGTCWDLINGYVCNCTAGYEGVLCQNEIDECASSPCLHQGTCTDYLNGYTCLCPPGYGGETCDQEDIDECASLPCLHQGTCTDHLDGYTCLCPPGYGGETCDQDIDECASLPCLHQGTCTDDLNGYTCLCVPGYDGETCDKDIDECASLPCLHQGTCTDHLDGYTCLCPPGYDGETCDKDIDECASSPCLHQGTCTDHLDGYTCLCPPGYGGETCHSETNECNSSPCLNGTCWDLINGYVCNCTAGYEGVLCQSEIDECASSPCEHGTCVDELNGYRCECDVFYEGTQCDTVIDEPCALPDPPCQNGICENTNSANDYNYKCTCDDGFYGTNCDIESKLYSAVVMVIGKLGDQSAFETKLANLLQKLYALQSRVRRDTGETVTVEIILTEDYVKSTDSSPLTRVTFLAWTESGYLQKDTMEAWIDGAPTDLPAQFGFDIYKGSAKPYTESWISSNWYIILLVVVTVALIVAVGFLFYHKGDLGRAKDAAIKYRGRDRAQSALETTFSTHKGEVDIAYSARIKDDAPTLPKRPDRPNMVESVNPAYTSSCDQSDYCGSATAGAEKAFFVALDGGGEKASNYYADIPALKAKAVAKENSYYEVGHISGVNPCRRVWQMGDDHAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5J9</accession>
    <name>A0A914A5J9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058789.1">
        <property type="nucleotide sequence ID" value="XM_038202861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5J9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202861.1">
        <property type="protein sequence ID" value="XP_038058789.1"/>
        <property type="gene ID" value="LOC119730075"/>
    </dbReference>
    <dbReference type="GeneID" id="119730075"/>
    <dbReference type="OrthoDB" id="5982450at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="349" mass="36374" checksum="30EDEC841F81C8E4" modified="2023-02-22" version="1">MVTWTPEPTATDDDGTTPEVICIPAAGSSFPVDETTNVVCNASDAAGNEAICTFNVTVDQQAPVIDNCPSNVRTNNAMVTWTPDPTATDDDGTTPEVICIPAAGSSFPVDETTNVVCNASDAAGNEAICTFNVTVDQQAPVIDNCPSNVRTNNAMVTWTPDPTATDDDGTTPEVTCIPAAGSSFPVDETTNVVCNAIDAAGNEAICTFNVTVDQQAPVIDNCPSNVRTNNAMVTWTPDPTATDDDGTTPEVICFPAAGSSFPVDETTNVVCNASDTAGNEAICTFNVTVDQQAPVIDNCPSNVRTNNAMVTWTPDPTASDDDGTTPEVMCIPAADQQCYGNLDTRSNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7A1</accession>
    <name>A0A914A7A1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059655.1">
        <property type="nucleotide sequence ID" value="XM_038203727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059656.1">
        <property type="nucleotide sequence ID" value="XM_038203728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059657.1">
        <property type="nucleotide sequence ID" value="XM_038203729.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059658.1">
        <property type="nucleotide sequence ID" value="XM_038203730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059659.1">
        <property type="nucleotide sequence ID" value="XM_038203731.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059660.1">
        <property type="nucleotide sequence ID" value="XM_038203732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059661.1">
        <property type="nucleotide sequence ID" value="XM_038203733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059662.1">
        <property type="nucleotide sequence ID" value="XM_038203734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7A1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203727.1">
        <property type="protein sequence ID" value="XP_038059655.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203728.1">
        <property type="protein sequence ID" value="XP_038059656.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203729.1">
        <property type="protein sequence ID" value="XP_038059657.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203730.1">
        <property type="protein sequence ID" value="XP_038059658.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203731.1">
        <property type="protein sequence ID" value="XP_038059659.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203732.1">
        <property type="protein sequence ID" value="XP_038059660.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203733.1">
        <property type="protein sequence ID" value="XP_038059661.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203734.1">
        <property type="protein sequence ID" value="XP_038059662.1"/>
        <property type="gene ID" value="LOC119730718"/>
    </dbReference>
    <dbReference type="GeneID" id="119730718"/>
    <dbReference type="OMA" id="KQAFPYD"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="363" mass="40308" checksum="9E70DBCCF9418288" modified="2023-02-22" version="1">MDQKKRCKGLMERLRDGETVICAEGYLFVFERRGYLTAGSYVPEVVLEHPELVRQQYEEFVHAGSDVVLAFTYYAHREKMALIGREDDLQRINKHALRMAREVADQTGTLMAGNISNTNLFVDSVPNYREKVWQIFKEQIEWAVEAGADFIVGETFSDFGEALMAVKACKEFAKDIPCVVTMAAQQGQVNGKPTTVDGVDYVDAFNKLAEAGADVVGLNCARGPATMLPVMEEAVKVCKAPLAAVPVMYRTTKENPNFMSSKDPLTGESLFPVNLDCIGCNRQDIHDFGKRVQELGIKYVGLCCGNSAHLTRSLAESLGRKPPASRYSADLNKHWLLGHDDKLPSVGQESKTKYAPKLTKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8C7</accession>
    <name>A0A914A8C7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CHFR</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Checkpoint with forkhead and RING finger domains protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase CHFR</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CHFR family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038059674.1">
        <property type="nucleotide sequence ID" value="XM_038203746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8C7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203746.1">
        <property type="protein sequence ID" value="XP_038059674.1"/>
        <property type="gene ID" value="LOC119730728"/>
    </dbReference>
    <dbReference type="GeneID" id="119730728"/>
    <dbReference type="OMA" id="SNYWFPG"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22672">
        <property type="entry name" value="FHA_CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16503">
        <property type="entry name" value="RING-HC_CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000203">
        <property type="entry name" value="E3 ubiquitin-protein ligase CHFR isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="20">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="470"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="732" mass="80192" checksum="8E8A06231C497F12" modified="2023-02-22" version="1">MSITRKDGEEWAQLVCTTDIDAPTLPICGEKFTMGRALGCNLSLPENKLISGQHCVLLRNEDGTVIVRDTSTNGTLISSSASKTRVTKGRSHKLQHGDEIFLVFKKEDPTKNVAYMFQDLSQLLDETLVNEDPESDEECTEEYEVKKTAADTRSGDTPTKRPASGVDPAEVGAVPTKRPRDNITDQGNQSDRLCQPPEPKSTDVPTTTSAAVPNAETAKQMDVASSGIGTATDTAATTAPGNGKAMGDSVAAVDTPVGATPGGGDAQVAAGEGIADNLICSICQDIFHDCISLQPCLHSFCAACYSSWMDISKDCPSCRNKVERISRNFIVNGLVDAFVKEHPDRKRSDDEKAEMDAKNKITRDMMVLSGKHQAGFDDDEDNEDSDDDYDEDEEDYNSDQNEYGYIPNRPNIMQGLFLPRPVAPVAACMQCPGYFGPGFDTGITMHPPIPPSSSAATNNAPCTAISATQPQTGAATTNQASHSTSTSSNTATTDQASTSTATSTGATAQPSTPAWAINCRGYKRTINGEYIPMPKVPQFQCQQGSNHLMCGCCHLQMPDRRHEYFNNPYGVPSQKCDVCGNFFCHRYWGCKKIDCNGCLNEFQDLHFGKKCLDNLILKNTYESEILKDYLKRKDLTWKDVLDSCMVKLDSGEYVCQDGAINRISSANVLCYHCGLKNFQELAYQYRRDIPKSDLPRQIASRPDCHWGSKCRTQANKLQHAKNFNHICEQTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8D2</accession>
    <name>A0A914A8D2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060093.1">
        <property type="nucleotide sequence ID" value="XM_038204165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060095.1">
        <property type="nucleotide sequence ID" value="XM_038204167.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060096.1">
        <property type="nucleotide sequence ID" value="XM_038204168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8D2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204165.1">
        <property type="protein sequence ID" value="XP_038060093.1"/>
        <property type="gene ID" value="LOC119731140"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204167.1">
        <property type="protein sequence ID" value="XP_038060095.1"/>
        <property type="gene ID" value="LOC119731140"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204168.1">
        <property type="protein sequence ID" value="XP_038060096.1"/>
        <property type="gene ID" value="LOC119731140"/>
    </dbReference>
    <dbReference type="GeneID" id="119731140"/>
    <dbReference type="OMA" id="DSATPCQ"/>
    <dbReference type="OrthoDB" id="10254686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000004">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF28">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="13">
        <location>
            <begin position="59"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="749"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="921"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1112" mass="121276" checksum="B50AFEBA0C160799" modified="2023-02-22" version="1">MSDEERSDSLQSVEIPNDMYQQAFMATNGNGPQMMGGLPSDLHQLEVMTGMSQQTLNDLSAPHLRILEQPKQRGFRFRYDCEGPSHGGLPGQNNQKGKRTYPSVEILNYTGLARIVVSLVTNDEIPKPHAHSIVGKHCNDGVCTVQLGPTDMTASFPNLGILHVTRKNVEKVLKDRLREQQKMYRSVLSDKDCRAQGMMDTEDQLAKKAKEVAKEMDLSVVRLCFQAYLPDATGHFNQPLAPVVSVPIYDSKAPGATTLKICRMDKSSGCVTGNEEVYLLCDKVQKEDVSVRFFEMNGNGDVVWEAQGEFGPTDVHRQFAIVFKTPRYKDCYIQKPVYVQVQLQRRSDKEVSDPKPFTYHPQLTDKESILRKRKKPLPSFQDHCYGGGGGKGGFGGTRGGGGGGGGGGYPFSTETPLNMNFGGGGGGGGPANSYQAAAPTASHNGNIQREQEHMSIMNQFRQQQQQHQQQQQQQQQQQQNQQGLVFQSRGVGKDSQRVVVLPAAAATGVKEAVQDSQPAVVPAVDATAMDENEVDSDLEVDSAPVEEPDVVSQHKLRDSMKPFADIIVERTKDMADSCVQTDDLPFDYDSLAWRLAERTSRALHDFAVTADIKMILAVQRHLTAVEDENGDTPLHLAIINKKDDVILGLLNVIISIPGQKIINYVNQLHQTPLHIAVLTKQRDVVEVLLRCGADPNIMDHKGNMPLHLAAQEGLSDITRLLVRGPPPPPGRDRLTIQPITAQINEKNLDGMTAAHISVSCGNHTNLKVLVKNGADVNIPDGKSGRTPLHYAVEQENFSFLSYLIGDADADIHAQTYAGDTPLHLACSLDYVAVAAVLISAGADPCVENFDTSDEYLGDVGVASSDGHLEEFEEYGTEKRGEDPDLCGKTPMNMAQSTRMASILNGEPYIPSLSYSIPSTTSTGSLPGKVTGDPATGTSDSGYQSKHASVYRPSTGTGLPRGDMNRLDSMVRRKLESLLDEVNPHKDWISLADKLGLGNMINQLRVFDSPTSILLDQYEAMDGTIEEMTAVLKSLNREDVLNVIEELKIPPKKVSHTLIDEVDRGTQVDSGLASSLHSMHLTSSASMSGPAKSHLKASQSSAFRNVNTVEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA60</accession>
    <name>A0A914AA60_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060742.1">
        <property type="nucleotide sequence ID" value="XM_038204814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204814.1">
        <property type="protein sequence ID" value="XP_038060742.1"/>
        <property type="gene ID" value="LOC119731612"/>
    </dbReference>
    <dbReference type="GeneID" id="119731612"/>
    <dbReference type="OMA" id="IFRYSCS"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037424686" description="Farnesoic acid O-methyl transferase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28673" checksum="2270D481EFFCB973" modified="2023-02-22" version="1">MQPCSVSKTIFFATVTLILSVFDSYAITSETLPGTRRADAILGDPDDTIFSGHAYRRIVGKSRLHCGATCAGNATGCLSFNYCHDTKVCELNSAGAAQHRQDLIHAEGCNYYDTSTRSVCGMVTDTTYYYRYLPSAVDVRRLEFWVQASHDAHVSLSPALPADPDELYEIVFGSGFNQWADIRRCALCPSEVDVPAPGVVSGSQFRGFWVTFDLHTGLLAAGREGQVTPIMQWVDPAPLDVKYVGFSTGWGSTGIFRYSCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA82</accession>
    <name>A0A914AA82_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060341.1">
        <property type="nucleotide sequence ID" value="XM_038204413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA82"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204413.1">
        <property type="protein sequence ID" value="XP_038060341.1"/>
        <property type="gene ID" value="LOC119731279"/>
    </dbReference>
    <dbReference type="GeneID" id="119731279"/>
    <dbReference type="OMA" id="KMAMEWT"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="148" mass="16982" checksum="D7843D95AEDB030F" modified="2023-02-22" version="1">MAATRIQKELKDLAREPLQIFSAGPVDGDLFHWQASMKGPSESPYQNGVFFLEIRFPRDYPFKPPKVQFQTKIYHPNINTNGSICLDILRSQWSPALTVSKVLLSISSLLTDPNPDDPLVPEIARVYKTDRDRYNKMAKEWTKSYAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD71</accession>
    <name>A0A914AD71_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061693.1">
        <property type="nucleotide sequence ID" value="XM_038205765.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205765.1">
        <property type="protein sequence ID" value="XP_038061693.1"/>
        <property type="gene ID" value="LOC119732306"/>
    </dbReference>
    <dbReference type="GeneID" id="119732306"/>
    <dbReference type="OMA" id="IHCTIDH"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1294"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3032" mass="332514" checksum="26D43A0A8504EA32" modified="2023-02-22" version="1">MQVCRLLPEENATATTLIYVCLPAGKIPRRGKTKNNSGKRRKAQKVARNSPSKEEAIDKTNKGNQAEDKLVNSRASTFSSAKTTAKKNNQSKGRMRTRRRRHGKTRQKPVLDEADRQTTSDDVKRDPSDALGDSYTSSGKPGKIRSKGKTKKRSGKTRKGQKLAKKSPSEEEAINKTNKGDQAEDKFVNSRDSTVSSSANTTAQRNNQSKGRKKTRKQTIADKKPSGEEKKESQIQLFVISSLRSPVCLQLHPSTTISALKGLLQDKLGIEPKKQRLYTRKNHELKGRMSLKELGIQQDTNIELRLVSGLMGGADDEQKSAGDSRERTDNDSGRRQKGKRKATKRRTSRGHEESVDNSKDSSISSAVKAAAGNPSGETPEEKLEQPTKDISRRRQKAKRKTPKTGTHLNSEENVDYSEDCSISSAVKATACNPSGETPGQQLEQPRKDNSRRREKEKGKAPKTGTHLGGEENGDDSEDSSISSAVKATAGDPSGETQEQKIDQPRKDNDSARKQKEKRKGNQRRTSRTGEVTVDDSEDCSICSAVNTPAGQPSEETQEQKLEQPRKDDDSERRQKEKGKATKTGTSSGVKENSDNSEDSSIASAVKASSVQQSGETQVQQKPEQPRKDRTSLRIQKGKGKAAQTKTSLGCEKNVKNSGDSTISSVVKAAVGQPSGETQEEKQEQPRKDDSLRIKKGKTKPAETRTSLGGEDNVKSSEGSPISSTVKAPTDHPSQEAQEQRLQQPRKDNETETRQKGNRKTSKRRTSCSDVENVDNSEDSSISAATAAVGHPSGEQPRKDDIGRVQKGKRKAANKSPSKAETTNMKSLGDTKQHKKNDHGDSCSSTEVRTDACTSSKNVAGTRKKIERQETAGSEAEESQEKTVASDIQQVDTGSSPASTTVAASASSRSKGRRRPKRKRKNAQKKQADDGGDSQILDLDRPQPEDQNVTGVMELSLQQGKKTALEQQTPKHNEAGNHQEISSETQGVGQEDYDPDKLKADLDRHLKNRPQSSQLQTVTSPEHPSLRCKQDDGLDRPPQFKKQEARSQMAKQEPIEQSCQQGLTVPERQAVKQEQIIDTEGPQPESWIGEQGFQQVRAASPGQLGREQSFHQGIATHENQGVEQKQASHHAQITQQDKHKVAEISKQNTQQSTSPENQRMRQERDDDLYGPDPNIQSTVAEQRPQEEVMTSAQEKPQPDRLHNEKLSPEQLQVVRDLVPSAVQPAMQHPSTLCTHHTSVSVQPTVQTGDVNVPGSCNPVFLGSSSGHTFHYEFNQNVTVHQGATSGVMENDLRPVQHSQPEVSSPSVQTSQGTSPANDAAADAAADLCEEALKKVYKTTGSYVQMIPWVGDDMMHIMDIYTKLRLVTDKLQSIRMRYEGKEVTYEDAFLEENEEGFVINRLIYEGMAGLGKTTLIGKIAYDWASSLSGLLAKYKLVFVLRMSALEQTADLLDSLFEQLIDPNIIHKKHLNTFIFKNPKKVLILLDGFDELMTTKLDNKSFGSILQILNRKVGADIDVVITTRTSHFDKLVSSALVKTPFTHVQVLGFAEEDVQDYLRKFFSKSKSPRDADSLFQSIQSSAVLLDLARSPMLILLMCLLWREDSTLPDTISRLYGKALRYIFKRKGIPEEKMPEILVAIGKVAFYGLISPVQRLSFQDREFDNSVLDIALKAGILTSQRGLKGLETHNNIQFIHKTIQEFCTAVYLQSLQKSDTDEFQKHLDKLDDIKRFHYLLRFCCGDNEACTIQVLQMLQKRINSESMYMYMKTTALNMGLNCYFESQAENLLSEAFTHSVITKIINTDYLESRDDVNSFVWFLKHVANQTKYTGNMYLDKVEELRFSHHSLEKCSKDLAVAMSSMPNISVVRMQRCSLTNNGMTDIASSLAKADKLSELDLSYNGALNGSLHSWMPQLIKKTHLQILMLDDCCLTAGDIKQIAALVGCMPTLVHCTVKGVFQLLPCSTGLKMELLNPMFSGSDVADIVKAVGSRNDIVKVVVEGAKGLGSTAAVWAPALRELKRLEHLKLNNCSLKSTDIEHIVASLSSTTNLVKLDVSRNPLAGSGVSLSKLLQLTQLKKLIIDHCVLNVEDVKWIAFLVGCLPKLIHCTVDDVFQVSTCDTGLKVQLLNQIFTDTDVADIVQAIGSRSDIVNVYIVHVQGLGGTAAEWSPALQELKCLERIDFKNCSLRGKDIEHIAASLSTNLVHLHVSGNPLAGSGVSLSKLKQLTQLKILKLYDCGLEVEDVICIAAVVGCLPRLIHCTIDHVFGVSPCGTGLKVELLGQTFTSTDVADIVQAMGSRSDIVEVAIACIQGLGGTAAEWSPALQELKCLERLDFKNCSLRGKDIEHIAASLSANLVHMHVSRNPLAGSGVSLSKLKQLTQLKILTLDDCGLEVEDVISIATVVGCLPRLIHCTIDHVFGVSPCGTGLKVELLGQTFTGADVADIVQAMGSRSDIVEVYIVRVQGLGGTAAEWSPALQELKCLERIDFKSCSLRGKDIEHIAASLSTNLVRLHVSGNPLAGSGVSLSKLKQLTELKILTLDDCGLEVEDVICIGAVVGCLQKLIHCTVDNVFQVSPCDAGLEVKLLNQTSTGTDVADIVQAIGSRSDIVEVYIVRVQGLGGTAAEWSPALQELKCLERLHFENCSLRGTDIEHIAASLSTSLVHLHVYRNPLAGSGVSLSKLKQLTQLETLTLDDCGLEVEGVISIATVFGCLPKLGYCRLISCFNGFNDLLWFEVVPCKIGIGIRLHLSSSKFRGPHVANIVRAIGCRRDLVDVTIEYIKNFGGKAAEWSPALQVLEHLKRFRISSSSLIDEDIKHIAASLGDIQTLVELDLSGNESLAGSGAWSHLKCLKQLKKLVLSDCRLSDADIGPIAASLSDISTVVELDLSVNVMLAGSGAWSHLKCLKQLKKLVLGWCSLSDADIELIADIPTLVELDLSGNVSLAGTSAWSHLKCLKQLTKLVLNMCWLSEADIELIAASLSDKLVELDLSGYQILADSDAFSDLKCLKKLKKLHLEYDSLSDADLERIGASLSCEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADA6</accession>
    <name>A0A914ADA6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061324.1">
        <property type="nucleotide sequence ID" value="XM_038205396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADA6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205396.1">
        <property type="protein sequence ID" value="XP_038061324.1"/>
        <property type="gene ID" value="LOC119732028"/>
    </dbReference>
    <dbReference type="GeneID" id="119732028"/>
    <dbReference type="OMA" id="GHHFPAK"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02904">
        <property type="entry name" value="Macro_H2A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035796">
        <property type="entry name" value="Macro_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Macro" evidence="11">
        <location>
            <begin position="181"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="39505" checksum="3CEEB164E7578952" modified="2023-02-22" version="1">MSGRGGKKRGKSVSKSARAGVLFPVSRMGRYLRLGTHHQRIGAGAPVYLAAVIEYLTAEILELAGNAAHDNKRGRITPRHILLAIANDEELHQLLRHVTIANGGVLPKIHPELLAKKKGPKYKMLLDSHPSPPPVKKPTYKTAAQKKEAPSTSKKNTPKAKTPAKKGKTPAKGKGKGSGKTVLSEKRLFLGQKLTVVQSNIAEILADVVVHPTNSSFYMGGEVGNALDSAGGKEFRDEMNKLKAAQGNLEVAGAAICPGHNFPAKFVISCHSPSWGGANAIPNLEKCVKNCLALADEKNLTSIALPSIGSGGNGFPKQTAAETILQTISKYFVTVMSSSLKQVYFVLYDQDSIDVYTRELSRLEVDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEA0</accession>
    <name>A0A914AEA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038062255.1">
        <property type="nucleotide sequence ID" value="XM_038206327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206327.1">
        <property type="protein sequence ID" value="XP_038062255.1"/>
        <property type="gene ID" value="LOC119732690"/>
    </dbReference>
    <dbReference type="GeneID" id="119732690"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="23">
        <location>
            <begin position="191"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="23">
        <location>
            <begin position="404"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="564" mass="64271" checksum="96508409001B4512" modified="2023-02-22" version="1">MPKDRYDSQNNHNNHRRQYRIMSPDDVVSGKKPHWEQLEIVGTIRNLSPNLWSLGFLTALYLNDNNLTRVPAEICKLTSLTHLDLSANKLRSLPVELGDLVTLRELLLNNNYLRNLPFEMGRLFQLQVLGLKGNPLNPDMLGLYNEHNGVPRLLSYMLDNISPPNTMPPTRPWIHIKDSDRSRPAAIFSVMSYNVLCDKYATKQLYGYCPTWALTWDYRRKGIMDEILHASADLICLQEVETDQYFNFFYPSLHKHGYDGVFSPKSRAKTMSEHERKYVDGCAIFYRTNKFGMVKEHLVEFNQLAMANADGNEDMLNRVMTKDNIGLAVLLETRAGSYEGSAPAPDNARQLMLVANVHIHWDPEYSDVKLIQTIMFMNELKKIVDEESISFRPGGTPRSQEACPIPLVLCGDLNSLPDSGVLEYLENGKVSVHHEDFKEIHYKALRNFSSSTESNGHIAHPFSLRRAYHNQPLQYTNYTYDFKGVIDYIFTSRNFMSTLGVLGPVEQEWLDQSKIVGCPHTSVPSDHFSLLTEFEMPYNAPGTSSNSSSAPSTSTSGNFNIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AED2</accession>
    <name>A0A914AED2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038061719.1">
        <property type="nucleotide sequence ID" value="XM_038205791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AED2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205791.1">
        <property type="protein sequence ID" value="XP_038061719.1"/>
        <property type="gene ID" value="LOC119732333"/>
    </dbReference>
    <dbReference type="GeneID" id="119732333"/>
    <dbReference type="OMA" id="GANGQYD"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000078">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mib2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000004">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="14">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="618" mass="68089" checksum="661FC85D14DB86B9" modified="2023-02-22" version="1">MFVGLRVVRGPDWKSGEQDGGKGCVGTAVPAEPAESTKGVWVRWDSGRKAKYRAGGANGQYDLRIYDNAQLGVKHPNMNCDGCQEDGIVGIRWKCLECHDFDLCHSCYNEGKHDLGHRFTRIETNSVPGVEVPCRLGATKCRSLGIFPGAKVVRGPDWEWEDQDGGEGEIGTVKEVISAQGTRRTWVKVQWPNRSTNQYRRGHGGKLDVQYKQEDTAGEFYIEHLPRLDATSLRPYLDTGDKVRLLDMDPTKLKELQLESCGWNEEIKDYRGKVGEVIAVDKDGDVKVNFGGASYFVNPLCLVMEKKKEAEDTRAGAGGTWDKLNVGELLAALYLKSELEKLGDLLVGSEDRSSGAVLFRAAAVGDTNKVRRIINDHPDAVKFQNYKRQTALQAAAHRGHVDAVNVLVKYKAPLEQQDKDGDTALSYAVLGNKPDIVINLLLAGSNINAANNNGLTPLHLASAEGHEACAEVLLRKQNCDVNYQDSNGNSPLFLAIAKNNKQIIHWLINHPQTDLRQVNKKGFNSLHHATACRNSFAVEGILRKLPNLINVVKRDGSSALHIAASNGLTEIILILVTQTVYDGLLLGVEQRVIDCGKWVLELHNQQSAADFALKFSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEF1</accession>
    <name>A0A914AEF1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061739.1">
        <property type="nucleotide sequence ID" value="XM_038205811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205811.1">
        <property type="protein sequence ID" value="XP_038061739.1"/>
        <property type="gene ID" value="LOC119732353"/>
    </dbReference>
    <dbReference type="GeneID" id="119732353"/>
    <dbReference type="OMA" id="PMITIGI"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="21554" checksum="92B66D5CB178C448" modified="2023-02-22" version="1">MADYRCPMITIGIIHIIDGLLIPAGITGIIASSGNSRRAVNVCIWFNSFGFAAAGAIITFAAIITSTNIVTDSDAGAIGAAIATVLLGVLEMILCCIAGTFSSRILRGIVAMEAATVTYSGDGVANPGMQNPEAQVQIQYPAQPPQGQYPGAPDQGQYPGPPAQGQYPGPPAQGQYPGPQAQGQYPGAPAQGQYPSAPVQYPATEEQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEJ9</accession>
    <name>A0A914AEJ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062370.1">
        <property type="nucleotide sequence ID" value="XM_038206442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206442.1">
        <property type="protein sequence ID" value="XP_038062370.1"/>
        <property type="gene ID" value="LOC119732838"/>
    </dbReference>
    <dbReference type="GeneID" id="119732838"/>
    <dbReference type="OMA" id="VCRREMI"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="524" mass="59620" checksum="22C7A3186EB026B8" modified="2023-02-22" version="1">MATALEKISNHLECDICQEKYKRPKVLDCQHSFCETCLEKYYTTRYAGQPKIPCPVCRREMILPETCIQGLKTNFHLMGIVEEVSLQEKVACSENTKVICEICDEGNEAMHRCLDCAQNICPNCRKTHLRFAATSNHTVASLEDIRQGKVTVKKTPEEDESKCQRHKGEVKRFYCETCEELICRDCTVVDHCKPEHHYIDSRKASLKYKQSLKDMFPDFTTDIKRLEQSLTTSSQAKQKFTQNVTKTVKAVKDKADKMRAEITTQETKMIEEIKQLQQHRNKIYDKHQETVTMMLQSKQHSFSTAQNVINTASDTDLLSLYPIISKDLKSLNSQNPPQINPKLSYLSFTPGQRIGDINLGKLETVKWEMCGEFSQWGSGPGQFQWAFGITATQPGEIAVADSGNNQVVICSNEGQHKGTIQLKSFDAAFGLNPQLGPGAEDHNHFVRKWKVQMEEAYSIAAQHAAKSTERGRKYHDQKARSSVLQPGDQVLVGRHQGPGKLRSYWEDQVYVVVQRKGEDCERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFL8</accession>
    <name>A0A914AFL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062770.1">
        <property type="nucleotide sequence ID" value="XM_038206842.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206842.1">
        <property type="protein sequence ID" value="XP_038062770.1"/>
        <property type="gene ID" value="LOC119733252"/>
    </dbReference>
    <dbReference type="GeneID" id="119733252"/>
    <dbReference type="OMA" id="KASHITI"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006946">
        <property type="entry name" value="DGR2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04862">
        <property type="entry name" value="DUF642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="3218"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2712"/>
            <end position="2749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2712"/>
            <end position="2748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3310" mass="361154" checksum="6FB0AC3B9BBF9EC1" modified="2023-02-22" version="1">MEQCSWRSDSNACYPGICTDGQCTCSSGFSGTDCRILGSSQAPVLSEHRATLVMGITTLESPTVQGSTDTVYTNVRDFTSIRADWISSYQPTGLPDLSSGGHLYIQSIGLGVVGARVTVVVNRGYSEIYSVGSQYCTTSTTGNSFNQNTPATDLVSCRLTFNLNYNSWAPATGDVLRYDVYSTSGGYMKLYDRDNSDSIITRNYNGRTTSGSSTFTFDFIGPNHCVDVGSGCRTTMLYAGNDVTSQAEIIVTWQGWADSLAGIKEYDLQVRQLSGSHGNEMTEIFDSPAVYSGVTNSSQNITLPHVGVYSIVLSAVDNAGNVRLSRRFVFFDDDPHDVTLRNDFSVRVVSANAESNYVWMTNLDSSGGSTSVQLDWTNRFMNAPHHNQGLLKPIGSYVSGTIDSDYDQNFGRRGRAAIPNTLGVTEFRVVHDIDHSGGRTTVNVSDDNSDHWSIEGTDTHATYDLTLVDGDSIRFWVEARDLAGHFLRDSVLVHADSSPPVIEDFWLVRDGEVNLAVHNSEDLDKMSVEFRTYDIHSGIRTIEWLLFDNHTGTEMANGSQTLSARKINTDTEDCDPVSCMCVPLGDCYAVDYGFHPTMHIGTHDYDYYITLTVTNEARLATTQTIKITVDASAPQAGVVHDGIPGSNEVDFQEGSDLSAHWEGFFDKESGVKFYQYLFDDSCRTGNTTVGNASNDMTRTTSTHASWTAPSPGQYYITVIAYNRALEPSAAVCSDGVVIDTSPPELTQIDISYARMWPGLAKDAEGRVWFINEHRRKMELMNASNDCSSMAALVDDLSVYPEVAGSDNSSAVLQGDQDCLGISPIEQKFFLPTDKHVTISWTGGIDTESSIYDYEIGLSSDPSNPTPDLVTFMSTSGHENFVMYHPHISHGAVFFLVLKAINKAQLTASKVVGPIVVDTTPPMFVGRVSVHVDDEYLLADWGDDGFIDDEDTSLRYQVAIGSSPGGTETLDFQKEKAYKIGPCLSRASCAAFSLADLDWHLHGDHEYYVSVRAQNGAGLATVGTSSVYRHIVQLPSLGVVLDVAPPGEEVHVDLGVAKDIDVQMSTTSISARWFGFEHPHLDINYEIAIGSEGGASDVSGGFIDVGNATFYRLDGLDLIPLMTYYVTIRANSEAGSVNVTSDGVKVIQEGQVLEGAVIKDGLGCDQDATSTPPGLSHHSSAAQQPCEDDITYQSSTSDISARWTIPEMLQPFVTGVFWAVEQEIEIYFDDENTTMEFIPVIDDQDLGMSFQHVGAGVGLHGGGHYRSKVQFCHVNVCFKPVVTDGFWVLSQPPEVGQVTVSDVEATPGGTEIRVVFQPFAHDYVRHDDPRELMDFYEWSIAEDGSDGALLSQWTRTQDLVVTGDVARFTASHSGSLDLDVCLQLSVRGYNKAGLSSIASTEIVDCDNVKLIVPHTVIDADHEVSMEQNAMWPEPDKNYISSTSSLSAVWPTLRHRDYVWAAIEDTGSFGNLDDGLQYPCDHPRSITCGSTDKEFINVPDLVLHHGKHYRICIHADEVTLEHELWNELLPAVSSCSDGVVIDTTPPTPGSVWIGWDQHQTYQSCSSELVLQWESFTDIEEHGLASHHSGVKYYEYAIGSMRGGSDVIDFTRVGITNSVIVHNLRLQNGHTYFATVRATDFVGLSSHAMSDSITIDMSPPVINADHSLDIGGSFIRSTTCISASWKNVFSDKESGVAYYEWAVGSHPGHADIMPFTRENTEIGVSDPSRPLHLHEGHSYFISMKAINTVGLITLKSYGAVTVDASPPLAGHVLDGNPADAPANHRDRDFQEDRRVIRAFWEGFHDPHSAIVGYSWRAGMCPGCSDVVTEQHVGLDTDVLAENLNLVPGLTYYVTVTACNAADLCTSVTSDGVTVDDSPPAPGHVYDGGPGGGGDISYQSSRRQLRAHWWGFHDPHSGLSHYEWRAGTTPGAADILPSTRIELSEDALIFLSAADQMPLGTDIYITVRAYNRLGTWSQATSNGFRVDSSPPDVVDAPTVDVTWGMAVRNTQVLRDLIHFSWKFNDPESGIKDQYVSVSTHHNGDVNIPSIKIAGSELDFTFTNLTLHEGSRYIVTVVACNMAGLCTQAKTEPLLVDGSPPSVGTFAVSTESAANLQRHHIIWIDPTEPSTTPDGTDYATDSIDSTTESPATTPSPPRYHSGWMTWLEDPRTSLGSLALAWLGFADVHSGISHYLVSAGRTYSGTELTPNGPVRVNHSTDGMSLDEGIAQTAIIPLEGSITDPTHPYLYISIWAVNGVGIPSTRHHATFEASPTLPGEGSLVLLRRCLPTTCKGHCACAPIDRTCNRDQFMYCTNVTHSNPNMEIEVLDVLDLMCDDINSVIDINDTATQSMAAAVWRVTEQKGLDIKWFEWSIGDDSSSNPVGIFNPVLDRIWYDIGQNNQTIITLDEDHKMAKGVKYHVFIRAWYNPTTYAVFRSDGITPDITPPKISTVRGTKIKDLARSDARKDTDYLTDPNVLFISWERVFLDDAMSHFQVSLSTYPGGEDIPQFADHTFPASVSSTQFTNLNLKSGLRYYSNVRAFNKAGLHTLKSSDGFVVDTRRPDAGLVFDGTDLHDVEYQNSSTLISASWHGFVDLESYLDHYEWCVGQTSSPADDGILPCTNVGIHLSASKTLAVPLTDGIQYYSKISAIDAAGLQSVSVSSDGFVVDTTPPEPLVQINLGDDLIQNPSFERIQEPDITDMEYEYTTVIAENETLNEASGTSDPNHGNVSDTYPTSATNLSTEEMSSTTSVHVTDGKRGEVLVQWDVGSDSQFAVVTSGKKIAEDGHSFLSLHGSIYQTFNTTQGSHYQVVFFASHPVPSHNPLLNQEGRIEAPGLDRIFRLYDRPAHSHSDQSLRSIRWHQHRFYFTASGDVATLKISSVGQSNGILLDNVQVRQITTRPSTGEGSVEVHTQFIHSWSSIQAKWHFIDPESPIVDFTWAIGTSKGGTQLQSFTSVGTQTDAINTDVMMAHGSYVYITVMARNAADLITIATSVSLLIDLTPPVIHFVKDGGDAHDIDFSADDSSLTFSWSASDPESGIDHCEWAVGSEPGLDDILPSSPSPDATSSITTSLFQAMVEGQRLYVTITCYNGAEKSSWKSSDGVTIVTVPPSSSAAVVNLKTVSETQYDTRDRYQSQRDSVKASWDGFMDPFGIQSYECHLSGPNAYDHWTPCGSTSETHLDWSGLTLDDDATYSLSVRAVNHAGLISQAITGNITIESTKPPGGALSLLSHSWLGDGRVDLTWDGLFSTSSSSSLVYEVSLGTIPGGSDIMQWVETMETGMRVSPLALYTDYHLTLTAINAAGLSQTVNKIISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFV8</accession>
    <name>A0A914AFV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062617.1">
        <property type="nucleotide sequence ID" value="XM_038206689.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206689.1">
        <property type="protein sequence ID" value="XP_038062617.1"/>
        <property type="gene ID" value="LOC119733110"/>
    </dbReference>
    <dbReference type="GeneID" id="119733110"/>
    <dbReference type="OMA" id="IICERHY"/>
    <dbReference type="OrthoDB" id="10053045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="519"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1300"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1371" mass="155559" checksum="8AC177D5D6E7AA92" modified="2023-02-22" version="1">MNDLPSVPNFDPHDVRGGSQGQHGQRQAWKKWLRSVELYVTGKGVTDVEQRKALLLHCAGVAVQDIFYSLPEKEGSDAYVKVKKTLTAYFETKVNVPYERYVFRSLFQANDETVAEVVVRLRHQAATCDFTNVDEQIRDQVIEKCKSNKLRTKLLEKGHGLTLQQLQTIAATIEMTETQTRHMAEGTSSFGGRKTVASVKPSTSMSRGRGSNSYPRRSTWSSASGSRGPSTSNRGRYPGSRGRGSSGASATVSQRGSAGKCYRCGHDGHYAKDKSCPARGKECNKCGMMGHFSSCCKTKMAPQGQNNKRGTVRNVDYEHEEHDGEYDLYSFSVNTVHVPTDETQVKVVVDKQVLDMIVDSGATVNIVDHETWEMLKANRIRCKSEKTTKRLYAYGSEYPLDLRGKFTTSVLLSGSDSAESIEAEFYVLNGKGPALLGRETALKLGVLKIGVDADVGGVSSVQSVHTKYPECFEGIGKLTNYQLHLHVDSDATPVAQNMYRIPYSLRAKVNDKLDELEALDIIEHVNEPSSWVSPVIVVPKPNGDIRLCVDMRQANQAIKRERHPIPTVDEVLYKMNGSVVFSKLDLKYGFHQIELDEQSRDITTFVTHKGLYRYKRLMFGINAAPEMYQNVISQVIGVGEGVANISDDIVVYGKTQEEHDQRLDCVMRKLKERNLTLNKDKCEFGVHKITFMGHTMSRNGIQPTDDREEALRNARRPTNSAEVRSFLGLVNFSARYSPNLATVAEPLRRLARKTVKFHWGKEQEDSFKKLKEALTHTNTLGYFRLDADSTQLVTDASNVGLGAVLLQEYDGQLKVISYASRTLTDVEKRYSTTEKEALAVVWACSKFHTYLYGVDFVLMTDHKPLEVLYGPKSRPNARIERWVMKLMSYSFKVKYLPGRDNIADVLSRLTKTTPAKEQETLQDETERYVRWVTSEATPKALTTREVEEASRADDELSAVRRCLNEDSWGTDVKDFFPMKNELSCIGFLVLRGTRIVVPKSLRLQCVQLAHQGHLGVVGTKQRLRTKVWWPRMERDVENFVRRCHGCQITGAMPAPEPMNPTPLPTGPWQDISIDLLGPLPSQEYVLVIVDYYSRYYEVDFMKVTTSDRVIESLENVFVQHGLPLTLTSDNGPQFTSDKFEAYLSENGIKHRKVTPLHPAANGEVERQNRSLMKRIRIAHAEKKDWKKEVREYLFSYRTTPHNTTGVTPAEMMFKRKLRTRLPEVEEMARQDEEIRDTDALRKERNRRYIDIKRGAKERDLEEGDEVLVRQSKQDKLSTPFSPEPYKVVAKKGNSVVVESPTGAQYQRNSTHVQKYNKPLNNHSDTPDTESRDSQQSLEGKTENTHTQVETESRPVRERKLPKRFDDFVMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG94</accession>
    <name>A0A914AG94_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062536.1">
        <property type="nucleotide sequence ID" value="XM_038206608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206608.1">
        <property type="protein sequence ID" value="XP_038062536.1"/>
        <property type="gene ID" value="LOC119733027"/>
    </dbReference>
    <dbReference type="GeneID" id="119733027"/>
    <dbReference type="OMA" id="WFLAIDS"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="70571" checksum="3296F4F441019C68" modified="2023-02-22" version="1">MATGPAVSSALETISRHHLECSICQERYQQPKILECLHSFCAQCLLKYCSTKHKGSTAIPCPVCRQETKLPESGVQGLKTNFYLIGLVEEFELQERVVCSGDTKLLCETCDDGNEATHRCLDCSLNICSRCHSSHKRVPVTSSHVIATLEDVREGKVKLKKENPRQHPKCPVHEGEVARFFCKTCDTLICRDCTVIDHCKPEHSYIDRNLATSKCKQSLAELVSPLENTMTELQKSREKVSRMKEDLGVAVKRVMTEVQDRAAEIRAEVTAQENRILDDIQNIQTDREQKLDECEKTMGFAVERFQYSLDTAREVTKTASDSDFLSLYATISKDLKLLADQSVPRVDNRLAFLKFKQSQGVGGISLGQVVTEGKWELCREFGRDGRGPGEFRGAWDITARQPDEIAVADRFNSRVVICSIDGNQKSTIPMQGVPLGIAATRSDNRLVVVEQSASHVKVFNSDNTLAYKFPTVPPSEVGKTTVDLWSVAVKNDGTIAVGDVARMVLTVHSPTDGELLHTIPVKIKPYSLAFDSNDRVIISGFSSQTVDIAGGNGATKRTIKPTINGQPVKYCNGVCTDGSGIYVAMQNGANTGHIHHYDPQGGFLQCIAQGLYYPRGITFSSHGQLAVADYSSVKMYHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGR1</accession>
    <name>A0A914AGR1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062902.1">
        <property type="nucleotide sequence ID" value="XM_038206974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206974.1">
        <property type="protein sequence ID" value="XP_038062902.1"/>
        <property type="gene ID" value="LOC119733394"/>
    </dbReference>
    <dbReference type="GeneID" id="119733394"/>
    <dbReference type="OMA" id="CHEEYTE"/>
    <dbReference type="OrthoDB" id="6265224at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="70721" checksum="E7148884D5326F87" modified="2023-02-22" version="1">MATGPAVSSALESISRHHLECSICQERYQQPKILECLHSFCEQCLLKYCSTKHEGSTVIPCPVCRQETKLPEVGVQGLKTNFHLIGLVEEFELQEKLVCSGDTKLLCETCDDDNEATHRCLDCAQNICSRCRRTQLRIAATSSHTIAALEDIREGKVKVTKEKPGQHPKCPIHDGEVTRFFCKTCETLICRDCTVINHRMPEHTYIERNEATSVFKQSLAELFSPLENSLTELQKSRERVSKIREDLGVTVKRAMTEVQDRAAEIRAHVTAQENRILDDIKNIQTDRGQKLDEYEKTMSLAVERFQYSLDTAREVTKTASDSDFLSLYATISKDLKLLADQSVPRVDNRLAFLKFKQSEGVGGISLGQVVTEGKWELSREFGRQGSGRRMFNGAWGIAARQPDEIAVTDYWKNRVVICSIDGNQKSTIPMQGRPCGIAATRSDNRLVVVEEGASHVKVFNSDNTLAYEFPTVPPSEVGKTTVDLQSVAVKNDGTIAVGDVARMVLTVHSPTDGELLHTIPVKIKPYFLAFDSNDRVIISGLSSQTVDIAGGNGTTKRTIKPTINGQPVEFCNGVCTDSSGIYVAMQNGANTGHIHHYDPQGGFLQCIAQGLHNPRGITFTSGGQLAVADWTSVKVYHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI87</accession>
    <name>A0A914AI87_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063363.1">
        <property type="nucleotide sequence ID" value="XM_038207435.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063364.1">
        <property type="nucleotide sequence ID" value="XM_038207436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207435.1">
        <property type="protein sequence ID" value="XP_038063363.1"/>
        <property type="gene ID" value="LOC119734073"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207436.1">
        <property type="protein sequence ID" value="XP_038063364.1"/>
        <property type="gene ID" value="LOC119734073"/>
    </dbReference>
    <dbReference type="GeneID" id="119734073"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="142" mass="16109" checksum="C9173E8644162857" modified="2023-02-22" version="1">MEEASVESCSEGVPCTEDYIQVSTVNGNEEISMDIRTVKEEVWSNVYHHGKIMFISQVVYSRDVHYVQDGIMSFMKSSTTNPHVFCQLPVCFPTASLCMPVFEHGSGKYADSVADKMKWCQPFCYRSVSNIQPYVIQDEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJF4</accession>
    <name>A0A914AJF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063544.1">
        <property type="nucleotide sequence ID" value="XM_038207616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207616.1">
        <property type="protein sequence ID" value="XP_038063544.1"/>
        <property type="gene ID" value="LOC119734238"/>
    </dbReference>
    <dbReference type="GeneID" id="119734238"/>
    <dbReference type="OMA" id="SINCHRS"/>
    <dbReference type="OrthoDB" id="6064581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53070" checksum="21F89BBFA57A6793" modified="2023-02-22" version="1">MVSPPSCSQTHLQRTRNSTCGPIRISPEQPASNLLHPSHSSSGVEGRCPQLRLVRNACSCLPPDLSHSTGPDKDRDGAIQSSPHSSILAKTAMVSSPSGSPGSLAPHTSQPARPPVTTRVSHSASGSIHSPSLCLDALKVSFRSAGLSEEATSLATKSRWRSTRRTYDSRLLHFTKWCEERAVNPRSASVTSIGDFFLHLFNSGLQISTIKGYRSAIGVLHQGFHDGTTTSSNTSISHMIRGMFNDRPPTRKLIPSWDLGTVLLSLSKPPFEPAGSSSLHHLTVKTIFLLAAATARRRSELHALSVEPGHIRWEPGGVRLIPRVGFLTKNQSMGFSPPDIFVPSLTSFSSVAEDKWWCPVRALKYYIARTKPLRGDIKQLFITTIQPHHKASVTTIARWISVAIQCHSDHRGSKSGAHETRSMSTSWAHLLGVPLSEIMKAACWKNPSTFTSCYLKDVLQAEGHMGKKVLQETARSAARSARTAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK75</accession>
    <name>A0A914AK75_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064132.1">
        <property type="nucleotide sequence ID" value="XM_038208204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208204.1">
        <property type="protein sequence ID" value="XP_038064132.1"/>
        <property type="gene ID" value="LOC119734676"/>
    </dbReference>
    <dbReference type="GeneID" id="119734676"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="27671" checksum="7580831B7809FC2A" modified="2023-02-22" version="1">MNHDHDFHHDVGAHHHDIHHDIHHHGIGHDHHGIHHDFHHHGIGNHHHDIHHHDIHHHGIGNHHHVVHHDIHHHPHVSSGATVGVQRVGRPAGGAMVVAVCFGMFGVFFLIGGVMMVAFGFNFFSGVGIVGAIMLSVGVAMLIACIVCCCKGCLQQQQQQQQQAFVLQPAGVMQPPPPGAPPIIQPQGPGPSILYGPGGQVAYQPQIQPGIQPPPQQYPAAMPYPQQVPDVPSAPPPSYEDIVKPAGGPEEHEQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALZ8</accession>
    <name>A0A914ALZ8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064767.1">
        <property type="nucleotide sequence ID" value="XM_038208839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208839.1">
        <property type="protein sequence ID" value="XP_038064767.1"/>
        <property type="gene ID" value="LOC119735107"/>
    </dbReference>
    <dbReference type="GeneID" id="119735107"/>
    <dbReference type="OMA" id="QHTWGFH"/>
    <dbReference type="OrthoDB" id="10017413at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029206">
        <property type="entry name" value="DUF4532"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35156:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15046">
        <property type="entry name" value="DUF4532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="290" mass="34281" checksum="C6B0DD6799630766" modified="2023-02-22" version="1">MRTDMAAPTTSNWHGYFEEETSPLTVRERDRLYDDRPQSMTAFHSRPVQKLTDKRPPRSRSKIEISHRMRTFVPDCVTPKPNDPFRLWIESGRKCAPFPPRWDPDYNSNVWRNFSSRVGYRVDSHDRSISELVADMYPMKIPPHSEMNDNTFVKFLSEVPMIKDRKRRDLAISRSVRELKDFKELKLRSEMRVPPITERGDIAPPKGFKKYEHRRLASPESTATQSLRQMTELERDSQRGVLGTHRTGGTRLWKLTFRENHPDYDQMQADQREKRLQPPKSPIPGEIWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AML7</accession>
    <name>A0A914AML7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065275.1">
        <property type="nucleotide sequence ID" value="XM_038209347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AML7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209347.1">
        <property type="protein sequence ID" value="XP_038065275.1"/>
        <property type="gene ID" value="LOC119735584"/>
    </dbReference>
    <dbReference type="GeneID" id="119735584"/>
    <dbReference type="OrthoDB" id="4207253at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="129"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="112260" checksum="C0C2C2D8DC9C657A" modified="2023-02-22" version="1">MLVEWKQRQTTTGCQMDVLCGALARIDRNDIVKCLQGNAQLTDLEYIQQLVLKYNMDTTSSIPAHPLDPSRTLDVDHFSRLELTRALKGKRTSNDEILLPSGKRTLDKDVKVLLKSWDDMLEPEVVGNIKALLSGGAGFGKSTLFLKIAHTSTDPKSKMAKFKLVFLVKLRQMETSCVLEAICDQILPRVEKAVLKKVIDDNEEKTAFLLDGLDEIPLDVLNSPAPKEGYGIKDILFNKVLRGSTVLVSTRPHMVDFAVKGYPKYARIETLGFTFETAKTYITSYFAEIDADKGKSLISHLTSSSFLRTLARIPIIALFLCIFWENQSELPEQLTVLFKEFAEALVSHRCNEGEDKVEELTHSVLCRLGQVALKGLLNPEGEMLRFSSKKFDEKDLEDGCRLGFLHTESFTSGLKEIKAAEFLHKYIQEYSAACYFANLHHTNEDDFKEELRKVNPYNVRAMKYLLRFVCGILSGSPATGLILEHVQKQLIEERCSDEEGSVGEEGSDAEEGSVGEEGSDAEEGSVGEEGSVGEEGSDEEEEWSDDEELFALKRINELQNLVRLLLLESGSKRMAVKLERPDQIGEEALSGEEGSVGEEGSDAEEGSVGEEGSVGKEKSDGEEGSVGEEGSDAEEGLVGEEGSVGEEESDGEEGSDGEEGSDEEEEWSDDEELFALKRINELQNLVRLLLLESGSKRMAVKLERPDQIVCDSHEDLLAMHYYSKCLSLIELKVLIVDCNSHNDFRLLRDIDERLRDHTSMRLRVNITCRSHEDVMLMRDMLQSDNIRSLRKCWVIKVKYIPSEKANKELQFIENTLEELDERLRERINLSLDINEMSHFDDDCVLGSLSRVCCRIGEIFLRNRTYEDCIRLVKMLDSCEQLYRLNVYNTNLHGHVGGVSPLVLRSLHDFSLTTCELDDDDVPDLIEILPAGHGLEILDVQGNAFSVDGVKKLTAHIKNLLELSMFVLFYKGPDKKQVDKVVLENLPHVRYDGCIVKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMX8</accession>
    <name>A0A914AMX8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064861.1">
        <property type="nucleotide sequence ID" value="XM_038208933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208933.1">
        <property type="protein sequence ID" value="XP_038064861.1"/>
        <property type="gene ID" value="LOC119735227"/>
    </dbReference>
    <dbReference type="GeneID" id="119735227"/>
    <dbReference type="OMA" id="HEYGNCA"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="155"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="237"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51714" checksum="5D16FEA5A59934E6" modified="2023-02-22" version="1">MSSDDVDSNQVCSVVIKSLFILHIHVDNVCINPNPCQNGGTCIPQSTGDFYNCSCPAGFSGGDCQNAIANTTTINVVVVIVVVVVVLIVVLVIVVVCFVKRSRRKRRGSRLSAVDRGRGQELIQKKLSNVYLIDTLQASTSKLNGPAKEFPRDKLHILGQLGSGSFAVVYKAEAEGIIRRGTNTTVAVKMLKECATPNDQSDFKKELRLYSMLDRHPNVLSMLGYCTDKDPMYIILEYVPYRDLQTYLRHIRTGTEPFYLKKEEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHRDLATRNILLGEGLVCKVSDFGLARDVAEKSQYEMQSQGRVPVRWMAPESLISNMYTSKSDVWSFGVLLWELVTLGSHPYPGMSSQKVIDEIKQGYRLPKPEHCSDDIYQIMMDCWQEKPEDRPDFAGLHTTIDDILADAAVGIQFPSRCTDHLSFYFSYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMY2</accession>
    <name>A0A914AMY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064789.1">
        <property type="nucleotide sequence ID" value="XM_038208861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208861.1">
        <property type="protein sequence ID" value="XP_038064789.1"/>
        <property type="gene ID" value="LOC119735157"/>
    </dbReference>
    <dbReference type="GeneID" id="119735157"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502165" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="104"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="225" mass="24750" checksum="042EA9180F9FB7F3" modified="2023-02-22" version="1">MAAISMATVQMSSVLRALITVLGVLPGMTYGHACWIGQEPDLASNHLRWALPAAGAAGCQCTDMKLGGVNQIQPRQPLHVQHVDAPLGLHAVKKELNCTGKEMCVPEGPLGMGDRRVPNDHITASSQYNWVDHAPWKARLTTDGTFSVWCNKPRTDPVPWIQVDFARDLYVTGLVIQGRSLYNQYVMSYELALSRDGEIWQPLTNADGTARRFISNEDSVNISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN69</accession>
    <name>A0A914AN69_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065197.1">
        <property type="nucleotide sequence ID" value="XM_038209269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN69"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209269.1">
        <property type="protein sequence ID" value="XP_038065197.1"/>
        <property type="gene ID" value="LOC119735533"/>
    </dbReference>
    <dbReference type="GeneID" id="119735533"/>
    <dbReference type="OMA" id="KQTSDMC"/>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502996" evidence="6">
        <location>
            <begin position="28"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="405"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="538"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="645"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="908"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="984"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1076" mass="117416" checksum="E75A363F7B9B8E8A" modified="2023-02-22" version="1">MEVPIYLLVDLLLCSLVLLLCQSLADSSPSFLSEPRSRIVKHNIRVKLRCKVDPKDAPIWWSFNGQDITDPASLGMQVTPKYLKIDSFQGEGERSHNGGYQCKAGNRTGLIVSRVAHVQAAYLRRFSTHLPATAYAKKGSVAVIECEAPDSIPPAVMSYEFKGQTIAGSSDHYRIMPSGHLHIINVSESDEGHYTCLATNPTLSKTHTAGNGTTLVLQEVSEVRIPPSIQTSRGVSVNIHERAVLECVAGGVPYPDVQWDMVEGSIPDNGVQYPGSLEITSVSRSDAGVYTCTALNEQGQSQRSEVTLEVIEPVSIAKAPKNTHVDLGGTGHFKCTVRGVNQNQIVWLFNGQRISEMSTRHEILEGQLIINEVSRSDLGPYQCFVQTDHGSAQATAKLMLREGFPAIVDPPVNTTAIEGENVFLSCGITGDPMPFVSWHDPLGTVVRNTRSMFISEETGGLTISRVGPDDVGWYRCTAANKHGRVAAEAYLAVIEKISTTPVPESSSRHVLNPPVNDDITITTQTTDEPNKPGTVPDAPTKPIIIKTSDTSVETRWDYFSRIPVTSFTIQYRDVASIDGWVTASNVIPLNRRVYEVQGLKEGATYRFRVIASNTHGDSEPSEMSNRFLMHVPGSMDPPVRPPLDPPRIINCVAMSSTSILVEWEFEPEFPDIPVTGFYVHYRNTDSDDDNDYTRTPVVGDDVRRYQIRNLEAELTYDIKMQTFNDGGESPFSNVIIRETMAQQTPPPPIIIPDPYPSNPSSGGRNPNIPSIPDDTEPDASTNQGEDILYITLGVVLGAMLLVLIMFGVMCIWRAKQVNNDRLARDWHYGYYCDGAYRHNNGNAYKFGHYMNGNTPQGHGGGNPPYGETATPADPRPLYTMPQDTLDEANYFPGLSPPTSPVANGHIPATNQTLQPSHMTSPNENTNSNHSSGASNEHLYVNGSCRSLRGAGGSLDREGHQGQGSLTFPGSGSYGTGDRPVCPSRHPKGDRSRRRKREGTTSREATDTEMASEVPPSSKNNVPPTVAQTAPSPGNETSSQQGLSPEVNLTLPSQGSHDSLNQSQDSGSCRIVKHSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANI5</accession>
    <name>A0A914ANI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065061.1">
        <property type="nucleotide sequence ID" value="XM_038209133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209133.1">
        <property type="protein sequence ID" value="XP_038065061.1"/>
        <property type="gene ID" value="LOC119735433"/>
    </dbReference>
    <dbReference type="GeneID" id="119735433"/>
    <dbReference type="OMA" id="GVMTRPN"/>
    <dbReference type="OrthoDB" id="10355666at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038058357" description="Protein quiver" evidence="2">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20750" checksum="1CBEC3B87A55CA46" modified="2023-02-22" version="1">MELSFTGMLFYGLILVSINYEVGAALSCYQCVDMEEMPDSTIDCDNPGDELLTVCDEGIAQCMLFEGVMTRPNGASQAGVARLCGPPPGAIPNTTIPENQCYCDQDAAHWLEVLIPIIAPDDLTVEGGFCFCNEDSCNRRNSTEDVCPHDDEHVHPTDGDGNATGHERALLWLIAMGVGFSWFSVGLFTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP80</accession>
    <name>A0A914AP80_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065240.1">
        <property type="nucleotide sequence ID" value="XM_038209312.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065249.1">
        <property type="nucleotide sequence ID" value="XM_038209321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP80"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209312.1">
        <property type="protein sequence ID" value="XP_038065240.1"/>
        <property type="gene ID" value="LOC119735559"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209321.1">
        <property type="protein sequence ID" value="XP_038065249.1"/>
        <property type="gene ID" value="LOC119735559"/>
    </dbReference>
    <dbReference type="GeneID" id="119735559"/>
    <dbReference type="CTD" id="22888"/>
    <dbReference type="OMA" id="FKKEPMY"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16660">
        <property type="entry name" value="RING-Ubox_RNF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039925">
        <property type="entry name" value="RNF37_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039847">
        <property type="entry name" value="Ubox5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045696">
        <property type="entry name" value="Ubox5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13492:SF2">
        <property type="entry name" value="RING FINGER PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19318">
        <property type="entry name" value="DUF5918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="581"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="644" mass="70143" checksum="32060ED6BEC2E5ED" modified="2023-02-22" version="1">MAVNMCRRDFGTVVTTSAVSADGYEVENLLGKTDMWGQPKGFVAECFIKPPVDVTFMFPFNLWIQKILIDPKVGGQMSIAVEVFTASVSMPPCQEDRSQSSLKGKTRTSNLNQKPNLRSQSQMLSEKDSAVFSSIGKAFSVDGKTACFCFVNHSYQPMYPQIGSSDARQEDTKPGVVTRSLRYAQPGALTNVSHVTVRVNRAASGSVAIRSVQIWGQPSMVCSKPSVQWFLQVAKPVENPELNRKKSEQVAGLKQNRACRSAASSGRKTLENCKRNVDPPDCPEEFLDPITIEMLVLPILLPSGHTVDSETLRKHGEAEALWGRPPNDPFTGIPFSKSRQPLPNVKLKERLDRYLLKGVGSVVPSARDVGRSGGMASGKTIPTPASLVRMTNQQSKSSGNTISKELLDAQPEKRQKFQRSSRQCGTSKTSTSTFRIQPDPIEMDTLRSGRGPKRKLNDHSLDEKLLSKKRPISSMHREQKVLECDNNWASAQLSNSLPSSSSSSSVGAAAATTTTAAAATTAAAAAATTAARASNSSHEELLSQSLDTALESALSSLPSFSKQPTQPSSYLADNLCHKWSCSSCHKTLARREGYHVNGPLNMYTLPCAHLMCRDCLSPRDGKTSGKCSVCDRRFQHSEVTKVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ33</accession>
    <name>A0A914AQ33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065862.1">
        <property type="nucleotide sequence ID" value="XM_038209934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQ33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209934.1">
        <property type="protein sequence ID" value="XP_038065862.1"/>
        <property type="gene ID" value="LOC119735957"/>
    </dbReference>
    <dbReference type="GeneID" id="119735957"/>
    <dbReference type="OMA" id="EIIIAHY"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="784" mass="90653" checksum="D9067E3876277DBD" modified="2023-02-22" version="1">MKPNPPCSMSPLRRTRRLLPRVLVLMMVLTLGLIWKMSSSNINVEKHVEHDMMIRQLPKSVDGTILKAEDWPTSSKDTHARNKEPRKHRIVIIGSGPTALGAAKRLYDLGQGKNNSVITILEELGRPGGLASSTRDDKGFLWDVGVHVVFSHYTYFDRVLNMAVPEWNYRRRASFAFMKGSDDKRRFIPYPVQNNIHVMDKIDQQKSLKGLEEITKSPITRKPTNFDEWLLQKFGVGLADVFMRKYNQKIWTVDTKEMNSAWVGERVAVPDIEEIKTKIKEVDNGIEAKDSEWGPNRFFRFPKYNGTGGIWQSVARMLPSHWFRFHEKVTGIDIDQKIITVEAGTVSKTHYTLEYDILFSTVPLDVFTSFLQSKDTSLEQMRQLASQLVYTHTHIVGVGLTGHLPKSLADKSWVYFPDSDSPFYRVTMFSSYSDDHVPKGGAFWSLMCEIAEPQKSSNPAYWSRENLIKESIQALVLYGFITADMVVSKHYRLLDHGYPVPSLKRDMLLDTIQPWLKTKDIYSRGRFGGWRYEVANQDHSFMQGVEAVDKILSDVPELTYPDPNLANSKKNTDRTIPLDYEIIIAHYNENLDWLKPYANHTLLYHHGKDLGPPFQFYGWERLKNVGREPHAYLHHITTYYDRLSDVTVFAQGDSMKGKCYKNPLQFIDSAKKGVPCIKLGNMHTDWGHIKFPGRYLDHYKNDPLVRSNETFGEVYQTLYGHPPPKEGIRYCWNACFGATRQQILRHSLEFYQKALAYVSKHSNQEESHYLERLWYHFFEGVDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR27</accession>
    <name>A0A914AR27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065846.1">
        <property type="nucleotide sequence ID" value="XM_038209918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209918.1">
        <property type="protein sequence ID" value="XP_038065846.1"/>
        <property type="gene ID" value="LOC119735946"/>
    </dbReference>
    <dbReference type="GeneID" id="119735946"/>
    <dbReference type="OMA" id="SQAFHPL"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF84">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="119"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="346"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="934"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="957" mass="110359" checksum="5F4BB6388F22B049" modified="2023-02-22" version="1">MEPGSHKRRTQHSEEPRRSSNTSRSSKVGPEPARVDKAGKHSKNNDMAAPPAIGFEGLQEDPPPKSEHIGLEAYGDGRSPKNGAAPENIELSESNKEDEPLKDDKQPKKAEKKEGADLYFHDGIRRIDYILAYKKGDSEKDVRRAAKRHEFENNLREEGIELEVEDPEPSQDGSADGNTVFVKLHAPWEFLSRQAEVLKVKMPIKENDMEEPISILNCLKKIPSPFDLSEEFIKPEPKYFTAPFVREREDEFVMEDRESFFGMSQRNRMVHEILEKCRYDPDNKTKFGIDHMINNGSYVAAYPLHEGDYKSKHSMLTHGPQNDRHLLYEEWARPGRWYKYQPLDLISDYYGEKIGLYFAWLGFYTQMLTIAAIVGLVVFLYGCISLPFDPVVSELCEAKSWVNYTMCPQCNNRCTYWILESSCFYSQLTYLFDNGATVFFAAFMSLWATMFCEFWKRRQNELDYDWDLFGFEEQEENCRPEFEALAPDKRVNPITKLYEPYVKFYRRFPRFMASVLGIVFMIFLVLAAVVGVIVYRIAIKTAVAASGDAFISSQASIITSITASCISLVVIMVLQNLYDRIATWLTDLELHRTETEYEDSYTFKMYFFAFVNYYSSSFYVAFFKGSFPGNPSEYGKVFGLRQEECDPAGCLQELFVNLAIVMCGKQFFNNFIEIFLPLILNFWRSRTGRKEQKAGKGSYDQWEKDFDRSELGPRGLFKEYLEMAVQFGFVTIFVASFPLAPFFALINNLMEIRLDAYKFVTQLRRPYAARAQDIGAWYAILVSVGNFAVLSNACVIAFTSSFISREVYKYQFDKLEGYVDWTLSSFNTTFFEEGTGPDIDTYPDFADGGLNGTRVELCKYRGFVLGPNPPFDLKLDYWKVFAMRLVLVLVYEHVIFIVKFALEYMVPDMPDFVKNEIKRENYLAQQALEEITRKDMVAKRRSKMPDGEKGASASGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATH0</accession>
    <name>A0A914ATH0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone H3, embryonic</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066779.1">
        <property type="nucleotide sequence ID" value="XM_038210851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATH0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210851.1">
        <property type="protein sequence ID" value="XP_038066779.1"/>
        <property type="gene ID" value="LOC119736841"/>
    </dbReference>
    <dbReference type="GeneID" id="119736841"/>
    <dbReference type="OMA" id="FMISGEM"/>
    <dbReference type="OrthoDB" id="7186325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30394" checksum="3D3D2F43D1B86486" modified="2023-02-22" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGGCSIDQSEGPCKGYILRGGFFKFHILFYSKTSKMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATP8</accession>
    <name>A0A914ATP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038067147.1">
        <property type="nucleotide sequence ID" value="XM_038211219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211219.1">
        <property type="protein sequence ID" value="XP_038067147.1"/>
        <property type="gene ID" value="LOC119737120"/>
    </dbReference>
    <dbReference type="GeneID" id="119737120"/>
    <dbReference type="CTD" id="1797"/>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="4">
        <location>
            <begin position="65"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="425" mass="49507" checksum="F5176A0756F13ACF" modified="2023-02-22" version="1">MKRSAESQEGHGDERHFKRVSRQLDSKILPPHSRRDGGSYTGPVPRTFAVRPTTNFTGQFPFFSRPRELGHFSLEIDRSFVNDDRHLKHYYPPSKESDLDLDLRQGFETFVKRDDNVKERLNNVMKWIIHNKQHFLKPERTVGVHYDTETDDMIESLGIDFIAWRGHFTKFLCTPNENREGWEMAVTLFRGTIYISEVETEQDRQHRLEMNHWEKQCMYGGYKFEQYVTSDGKKAPDPSQPVNNIEAFCTVVRSDLGPFKLLYSGEVDCLQPGSTLKPPENYLELKTSRKWYTHKNESSFYRYKLLKWWAQSFLVGIPEVICGFRDDDGVVQEIKHFKTMEMPKHSMGSWDGSVCFNFLLKLLAFIKSVAVIDDPSMVYLFERKPGESVISYTEHRADGQQFIPEWYISAFKNDSSASSAEAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUK5</accession>
    <name>A0A914AUK5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYND domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZMYND10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067194.1">
        <property type="nucleotide sequence ID" value="XM_038211266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUK5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211266.1">
        <property type="protein sequence ID" value="XP_038067194.1"/>
        <property type="gene ID" value="LOC119737148"/>
    </dbReference>
    <dbReference type="GeneID" id="119737148"/>
    <dbReference type="CTD" id="51364"/>
    <dbReference type="OMA" id="LIHEAYC"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000009">
        <property type="entry name" value="Zinc finger MYND domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="16">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="52245" checksum="A6C8B1EA5EADADE3" modified="2023-02-22" version="1">MASDGASILLSSEAEAYVESLEVIPIKDIGSPRWTKQHEYVEKLNMQAVLHAAANEDEYIKELLIQHDKIPVLISDLMCTEVWQQKVFSIIKRMDFEPRTTVPLYMSLYHEATLVNLLETILYHKEPCEAAGDCILDIVDYCYRKITYLIARQESGEDEDEDEEATPTKASSLEEERGMEELKKQERKLQFDVSIKAVSILRFITDHISDMSLSVTSRILNTSDFPCLLVQLMENPPWTKYRNGVLKKFIDGKWHTVPPSDRMRLTKLEGQVWIALFNLLLGPSCQEKYEFNSHNKAQILKLRAHLSEVILDQIPSLCDLQRYLSHLSMMDPPSSKTGLVLEQVPEIRDGILRANEGKWSAIAKHQVKTVFNPSAAAMREQARRFAETYRLDALETLITEPPKCAVCGQPATKRCSRCQNEWYCRRECQVQHWSKHKQACALIAESQQAIKTNGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV90</accession>
    <name>A0A914AV90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038067201.1">
        <property type="nucleotide sequence ID" value="XM_038211273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211273.1">
        <property type="protein sequence ID" value="XP_038067201.1"/>
        <property type="gene ID" value="LOC119737153"/>
    </dbReference>
    <dbReference type="GeneID" id="119737153"/>
    <dbReference type="OMA" id="HEGQRPP"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="92057" checksum="5E6EFC1DBEB00B20" modified="2023-02-22" version="1">MPYILTEDGPYYWLTSTEIMSHPSKQSQKPLDSSEEEEQQDNSYYREDEIDRDDKADRDKREERYREDDEEEEQLGSDDDEQEDPKDYCKGGYHLVKIGDLFNNRYHVVRKLGWGHFSTVWLAWDLKGRKYVALKVVKSAQHYTETAVDEIKLLKAVRESDTSDANRERVVQLLDDFKVSGVNGTHVCMVFEVLGNNLLKPIIKSKYMGLQLQQVKSIIRQVLEGLDYLHTKCHIIHTDIKPENILMCVNDEYIKKLAHEAKDWVQGNAKPPVSSVSTAPIEKKPEKLSKNKKRRLKAKQKKQIALLEKQEQQLIELEKERHSRVSVTPDKDQPNCMETERQHAGSSGSSNGNQTPLSETATTPGSEYPTTPSSEYATTPGSEVAPVNGIGSETAMQGVQEEVESEERNDRPDSEGTECQTDVTEPTTNGNGNPKETNILITDTQEPEDETSETPNSPQRLKPQPLPMVDPMTDPMTESMGDGPWVEPQGTGELCNGYGGEGGDMEGEEKVEKEGGEKNVGLQNGETEHSKMNGDRDDHQDDLVKDRSPADSTLEENRLQDDTSPSKEVELRSVDEETRQDTTEAEERQEEEAGRGGGDERKEKRELEKDTEEQDAILDAETASKEDAIKMENQNDGAESQSANDDNELKVKLADLGNACWTHHHFTEDIQTRQYRALEVIIGAGYDTPSDIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHISELLGTIPKHIALGGKFSREFFNRKGELRHITKLKPWGLFYVLTEKYDWVERAAIEFASFLEPMLEFDPTKRATAAMCLKHPWLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW49</accession>
    <name>A0A914AW49_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067923.1">
        <property type="nucleotide sequence ID" value="XM_038211995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW49"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211995.1">
        <property type="protein sequence ID" value="XP_038067923.1"/>
        <property type="gene ID" value="LOC119737525"/>
    </dbReference>
    <dbReference type="GeneID" id="119737525"/>
    <dbReference type="OMA" id="GYISACD"/>
    <dbReference type="OrthoDB" id="6597534at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="18473" checksum="9A3ED77703E09FD1" modified="2023-02-22" version="1">MSKEVAAIMSNGFSEDQFSEFKAAFSLFDKDGDGTVTSDELAVVLRSIGLNPTKRELDKIIKEADADGNNTIELNEFLATISQKMVQEEKGRADDDIMTEQEIKKTYDIFDSNGNGYISACDIRRVGALYGECFTDEVANQMIGEADTDADGRVTYRDFLKMMRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWP7</accession>
    <name>A0A914AWP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 313</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068535.1">
        <property type="nucleotide sequence ID" value="XM_038212607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212607.1">
        <property type="protein sequence ID" value="XP_038068535.1"/>
        <property type="gene ID" value="LOC119737932"/>
    </dbReference>
    <dbReference type="GeneID" id="119737932"/>
    <dbReference type="OMA" id="AHTFCGD"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034734">
        <property type="entry name" value="ZF_C2HC_RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18574">
        <property type="entry name" value="zf_C2HC_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51803">
        <property type="entry name" value="ZF_C2HC_RNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC RNF-type" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24328" checksum="F0AAD8D5C63254DB" modified="2023-02-22" version="1">MATGDESDDGLKCAICLDVYCKPIKITCEHTFCEECLAPYLDVPSPNCPLCRKVFDPKKKAKAKDIEKQISSTKSVCTGCSKKMSMSKIRSHTATCPKMGTMTDSASKFKPVATTSQKAPRDVPNRSTFKCPFCGLKNLDSNDLNRHCNKEHKETTMSVVCPICASMPWGDPNYQSSNFIEHLNLRHKFEYDTYVDYNQDEEEILQKVLESSLQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY45</accession>
    <name>A0A914AY45_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meckelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068622.1">
        <property type="nucleotide sequence ID" value="XM_038212694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY45"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212694.1">
        <property type="protein sequence ID" value="XP_038068622.1"/>
        <property type="gene ID" value="LOC119737995"/>
    </dbReference>
    <dbReference type="GeneID" id="119737995"/>
    <dbReference type="CTD" id="91147"/>
    <dbReference type="OMA" id="YITENKG"/>
    <dbReference type="OrthoDB" id="419138at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019170">
        <property type="entry name" value="Meckelin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274:SF0">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09773">
        <property type="entry name" value="Meckelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617175" description="Meckelin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="110427" checksum="4B93859A71CB0A1B" modified="2023-02-22" version="1">MHSSMAARGSLIFSFLGFVFMSFLAHVTGVTYSIPFQADCVGNQYFDLAGLLCRDCDSVSQVKSVDGLSCQCRPSYKTTRNFGGPSTTVECEACAAGQVGTVDGWNCIDCETADCLNCNAGDIGEEYSIAGVLQGTKTCTTCDAATLPDSAGIQCERCHESFLAVNNDCTCNTPLVGGLCFGVNEIQAPAQDTFQVSYEALDAPLSSWYYMEYLQAAEAMCRLYQNLTACQMLGNLCVLLHYNPNSLNDACGYFEAIRGASATPLIGDNPDWVVYMPWLKYVADPADEILTEINIPTKFSAEPTSEDSTLKLFVAQYSATGQYRGLGSVRGGVIQLCNDTEKKMNAAYTFATSYSSSCQLKAQDLWNNYETTFFDMYLQYTEGSSTVLYAVPVLLDNYQDDGTFENRQETNTNWQLTRRFFLVDNVSGKTASNTPATVIRYASSIELLVTLQDEAGQTREGKIYPPLLKIQYSELVYENDYDSNTEVTVNFRVTYEMSRDYGENALSTALGILSGVGVVWALVRSNAWRRRAGLIYIDIKTMFKFFFFGLGMLADVFFVCLFGTTLYWLFFFKRQDLVYLVLPHKAQEVSFIWYLSFAFFCKSLDVLHLIVYQCLSDVFLIDWERSRGRVVQSSDPGSNKGSVAPVSIWRTYFVANEWNELQEMRRSSIFFQMSAMLFFLEVIGLKNLTTMDPRSDVYVDPSDYTGDPSRVLRFAVASGIYLLLSLLQWIFFAFIYERFIADSMRNFVDLCSMANISVFVLIDNTFGYYIHGRSVHGFADTDMKEMRDQLKREEDNLCGQRGLLPNSEQQTFEILLPMKFREQYNTILQPLDGVAARIDGTRGRPDAGRNQEAEKSIQAYQTMNRFLAAFLDHGIRDIDYVVKDKLLLEQILDMEFYDPADKGFFFNDGGHAFDNALFHGNESTLQLFELLLFCIVDLMFTNFVLAAIITYIGSAFLLKVRAAGGRANLAKKTLVDERFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYN7</accession>
    <name>A0A914AYN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">28S ribosomal protein S27, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068783.1">
        <property type="nucleotide sequence ID" value="XM_038212855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212855.1">
        <property type="protein sequence ID" value="XP_038068783.1"/>
        <property type="gene ID" value="LOC119738112"/>
    </dbReference>
    <dbReference type="GeneID" id="119738112"/>
    <dbReference type="CTD" id="23107"/>
    <dbReference type="OMA" id="REDIDHA"/>
    <dbReference type="OrthoDB" id="19830at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47592" checksum="11D809BCC0BFF077" modified="2023-02-22" version="1">MALYMRTCALSLSTFILRRTLRPNQANILFSVIGVAIRGQRTLLTDAYKGTSAWRTRKILAVNMDELKISLDADFFDFKKPVASVDLHKFIDNISDEHDLKSAEQYLFCHRHSPVAHHLRASTAHCFIRACLDLGQANTAFKVLQDKTNYGLFPDNFTFNLVLDDYLEKRNIKGAAMVAMEMMTLEVLTNQEPLSQLLALYACHQYLKSGDSTEEEMHNLGMTFADATRSQTSLLSSSYHALGLVMAGRLKQAISFLQATTDLTGDNEPCVAQQAVEQIQTALESRSDVKEELRSKLQECLSKLQADSKISAESLDSLVAAETLPKVQELQQNHTHSEKYPEMLAEWHLEHVEAVRRQIRAAQEYETSLKRTKLEKLLEATGGLKYWLEKEERRKREREAETGRDKSGETGEEQDVKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZZ9</accession>
    <name>A0A914AZZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068831.1">
        <property type="nucleotide sequence ID" value="XM_038212903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212903.1">
        <property type="protein sequence ID" value="XP_038068831.1"/>
        <property type="gene ID" value="LOC119738158"/>
    </dbReference>
    <dbReference type="GeneID" id="119738158"/>
    <dbReference type="OMA" id="TAFHRMV"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="182"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="346" mass="39777" checksum="15B35EBEB06CEFAC" modified="2023-02-22" version="1">MEVDEKATDFDACRQAALAWLEHHSKPWQLLWADETERQLVFEHRTGGISFNIVVQSSAAENGQRCFKVASDNDSAWQLLKECQGTSIQECLEQSTAALQPLVGSHNTGTEDDEGVDEDDDDEDEDDDENEDWYYENNEDMMDTEEPEKVNRVSPEKRKSPEEHGDTSDVDFEMYAKFGSRMAVRRLLSDLKMFKRSESANGIHGSPRGDNLFLWDVQMTDFEPKSVLGKDLCKYADKYKQKLEIQLEMSFPDDYPMAPPFIRVVRPRFKFLTAHVTIGGSICMELLTKSGWRPTNDIESILVQVRSEIVSDPKAALDMDRANREYTKTEAETAFHRMVQRYGWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B199</accession>
    <name>A0A914B199_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069767.1">
        <property type="nucleotide sequence ID" value="XM_038213839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B199"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213839.1">
        <property type="protein sequence ID" value="XP_038069767.1"/>
        <property type="gene ID" value="LOC119738866"/>
    </dbReference>
    <dbReference type="GeneID" id="119738866"/>
    <dbReference type="CTD" id="25839"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000014">
        <property type="entry name" value="conserved oligomeric Golgi complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1970:FF:000001">
        <property type="entry name" value="Conserved oligomeric Golgi complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="9">
        <location>
            <begin position="170"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="756" mass="85570" checksum="1FAEDB8137B610D3" modified="2023-02-22" version="1">MASATSSPFDAMGVQNLTDISDIQEAFEQLCVEEQAITDDVDGLLEKQTNLEAKMNSLQRLGQNLQLVHTDAKQLGSMISFTSDLAENVSGKVRELDVAKNRVQIAIQRVNDILDLKFCTDGVQTALQSENYEKAAGHIHRYLSLDEKVLKQVIADNKEGGGIDLSISHLHEAEQNLKALVREKFDSAIQSRDRGSVERFFKIFPLLGLHDEGLEKFSTYLRTQVANKAKENLALSLSKDSSDRRASVIYADTITMLFEDIGKCVEIHQPLVETFYGPGRLFTLMQSLQQECDVQAKKIVESFVRNRDFDTRAQQVQQSLRGYKSSNPNDKLDPRDLDVMLAECTLLNTRTELYLRFVKRRILSDIEVLDEDVATKQARQGELDRFLMNCQLSRHMQELIGNYIMMEEYFMHETVTKAVSLDSLESGSHTSSMVDDIFFIVKKCTRRAISSGSTDCACAMLNHTSSLLEGSYRDVLYSKLRAGYPSGSFDVSQAYNMLQQGRFATSTTDTNAAKLEFLTTLNNIEVSIDFTQALKKSLGDECASRNQHLGDKEREKLESCLGDLGNVTHKFKDVLEYGLSQLSTSAIKPRLKPWVDNFLSTSHNISEEEFSNYEANDPFVQTFIINLEQLLKEFKELLTPANYDALIGLLTSEVTTQLEKTVLKSVFNRLGGLQYDKELRSLVGYLTSVTQWTIRDKFARLTQMATILNLERVSEILDYWGSNSGPLTWRLTPAEVRQVLSLRIDFRTEDIKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1L9</accession>
    <name>A0A914B1L9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069802.1">
        <property type="nucleotide sequence ID" value="XM_038213874.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069808.1">
        <property type="nucleotide sequence ID" value="XM_038213880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1L9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213874.1">
        <property type="protein sequence ID" value="XP_038069802.1"/>
        <property type="gene ID" value="LOC119739039"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213880.1">
        <property type="protein sequence ID" value="XP_038069808.1"/>
        <property type="gene ID" value="LOC119739047"/>
    </dbReference>
    <dbReference type="GeneID" id="119739039"/>
    <dbReference type="GeneID" id="119739047"/>
    <dbReference type="OMA" id="NESIRMC"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF14">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="426"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="912"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114542" checksum="630AA6EDCE40EAA8" modified="2023-02-22" version="1">MTDFTVLTVRSAIPFERGYRGEEPSTKSYTELVDVLRKHLAPKPLVIAERFRFHKRDQREGESVTAYLAELRRLTEYCEFGSYLNDALRDRLVCGLRAGNITKRLLAEAKLTFKKAIEIATAMEAAAKDAVEFQQQLKPETSVHKFAAKPQPTSTSTCYRCGKSGHSPNQCHFKDATCHGCNKKGHIRPVCRSSASPQQASRPRNSRKGRPQGGKAKAKHMKSVEEASSDDDMTYVGRLGVNNLDHRKDSTIWLTPSINGTNIRMELDTGSAVSVISKADYQRHFANSKLESTPVKLQTYTGEKVSPVGCLQVDICYQEQRHTGLLYVVQRGGPALFGRDWLAHFKLDWPSIFAISSEHPPVNMEAKLQALLDSYPELFKDEIGERTDIRAKLTLKDNAHPVFLKARQVPYALRPQVEAELAKLQQQNIISPVETSEWATPIVPVPKKNGGVRICGDFKVTVNANLHVDHYPLPKIDDVFATLAGGQHFSKLDLKQAYLHMVMDEESSKLLTLNTHKGLFKMNRLAFGVASAPAIWQRTMEQIIQGIPGVQCILDDMLITGRDNTEHLRNLEKVLSVLRDRGLRLNISKCEFFKSKLLEKNHKWAWSTECETAFEQAKTLITSEEVLTHYDPKLPVKLACDASPYGLGSVMSHVMPDNTERPIAYASRTLSSAERNYSQIDKEALALVWGVKKFNNYLCGRKFTLVTDHQPLTSIFHPAKSIPAMTASRMVRYAVFLASYDYEIEYKSTTKHCNADGLSRMPLPEVRVEHTDPDDILHLSQFDTLPVTSAQIRKETARDVVLAKAYEYTMKGWPHSHDSELNPFHARRHELSVHNGCLMWGLRVVVPAKLRDKVLIELHEGHLGVVKMKTLARGYMWWPGIDSDIEKLAKGCSGCQLVQHNPKSAPLHTWEWPMSPWQRIHIDYAGPFLGQMFLIVVDAHSKWPEVVSTKSSDSSHTIDILRAIFARNGVPEQLVSDNAPQFTSDEFQMFLKRNGVKHITSAPYHPATNGLAERFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1M4</accession>
    <name>A0A914B1M4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Katanin p80 WD40 repeat-containing subunit B1</fullName>
            <shortName evidence="11">Katanin p80 subunit B1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">p80 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KATNB1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
            <location evidence="1 11">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Microtubule organizing center</location>
            <location evidence="11">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <text evidence="11">Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat KATNB1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A914B1M4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213969.1">
        <property type="protein sequence ID" value="XP_038069897.1"/>
        <property type="gene ID" value="LOC119739142"/>
    </dbReference>
    <dbReference type="OMA" id="AMDVQCP"/>
    <dbReference type="OrthoDB" id="10251605at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000846">
        <property type="entry name" value="Katanin p80 WD40 repeat-containing subunit B1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03022">
        <property type="entry name" value="Katanin_p80_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026962">
        <property type="entry name" value="KTNB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="14">
        <location>
            <begin position="522"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="683" mass="74856" checksum="806DEE8BDBAEB73A" modified="2023-02-22" version="1">MTTKRSWKLQEFVAHGANVNCLALGQQSGRVMVTGGDDKKVNMWAVDKPNCIMSLSGHTAPVECVRFNHNEELVAAGSQSGSLKIWDLEAAKIIRTLTGHKSNTRSLDFHPYGDFVASGSVDLNIKLWDIRRKGCIFTYKGHTGPINCIRFSPDGRWIASASADGLVKLWDLTSGKLLHDFKLHENSVNHVEFHPNEFLLATGSADKTVKFWDLETFDLVSSTSPSASEVRALVFHSEGNFLYSGSQDMLHVYGWEPACCYDTFSMGWGRVADLAVASSQLIGASFNQTNVSVHVVDLQRVNKTRGVSIQQLQQGQPAGTSQGQKPASAAPLSASGRRSFVTERPPTTSTKQREPEIKSEAQRESPTQDEKEDDSASSADIQDPVNYDSIFHPKKRISRSPTRDQPFPAPLDDQPPAPSQPPAPQPKQTSQPPPQAPSQPAPAPKLQPAAAAVAAPEPAPPPQRQPDPAPQRTPQNIISSDRNQPAGLDMNAFLPQNMRGAGGDQKTRAKETEAEALDSLMKGHNSMCAVLTSRNKNLDVVRAIWTAGDIKTAVESAVNMRDQAIIVDLLNIMNIKKSLWSLDLCVILLPKIKELLTSKYENYVHSACASLKLILKSFTSLIKSNVKMPPSAVDISREERYKKCSKCYGYLLAVRTVVEDRQHVAGKVGSTFRELQLLLAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2B4</accession>
    <name>A0A914B2B4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069934.1">
        <property type="nucleotide sequence ID" value="XM_038214006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214006.1">
        <property type="protein sequence ID" value="XP_038069934.1"/>
        <property type="gene ID" value="LOC119739177"/>
    </dbReference>
    <dbReference type="GeneID" id="119739177"/>
    <dbReference type="OMA" id="YYDEQLA"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF21">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="30960" checksum="C5EBF99B4317895E" modified="2023-02-22" version="1">MALAAVRRILRPCAGLHGKNLLACRSLATSSAHSTAANQQAREDLAAAYRGLDFYGMGEGICTHLTTRAPSRSGSGDMMLLIPYGLHWSEVTASCLIGVNIATGQVMEGDGDVEPSAANIHTAIYKSKGDTVNCIMHTHQFYTMLLSCLQESELRNVHQHCMRFHGKVAYDRAYGGTAHEGEAESTRLARNLGDKDFLIMGNHGVLGVGHSVAYVFDSMYYLEKAAKLQVMAAATGMKPFEASDEVAQKVARYFDTHGAKFWDKHFLGIKKLLERRQPDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2S9</accession>
    <name>A0A914B2S9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070312.1">
        <property type="nucleotide sequence ID" value="XM_038214384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214384.1">
        <property type="protein sequence ID" value="XP_038070312.1"/>
        <property type="gene ID" value="LOC119739433"/>
    </dbReference>
    <dbReference type="GeneID" id="119739433"/>
    <dbReference type="OMA" id="CECALAW"/>
    <dbReference type="OrthoDB" id="261614at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="20108" checksum="97562F96B054AE8C" modified="2023-02-22" version="1">MVMMSARPNPDYGSMTLKDLRAELRKRNAKQSGRKHELVTRLESYDRNFNFGHTCIQCEDERGFHMTTPKPTDYKGINTDSKIPVVTADSITTFHELHGQDLQEKTEALYYGKFLQSVRYCNQDETVYFIGRVSAEMKTKVIYKVDIKINKHGVVEESQCECALAWDRRPTASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2W1</accession>
    <name>A0A914B2W1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069836.1">
        <property type="nucleotide sequence ID" value="XM_038213908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2W1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213908.1">
        <property type="protein sequence ID" value="XP_038069836.1"/>
        <property type="gene ID" value="LOC119739072"/>
    </dbReference>
    <dbReference type="GeneID" id="119739072"/>
    <dbReference type="OrthoDB" id="6233064at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037320988" evidence="7">
        <location>
            <begin position="26"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="247"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="398"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="512"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="548"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="688"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="877" mass="94453" checksum="6F0C0B0FB2F3E587" modified="2023-02-22" version="1">MRRFLSKAIGVLTGLTLLLPSVILADSELNLINLAANESAIISSPFYPSNYQNNLDIQWVIQTAEDFRILLSFLAFNTESCCDHLSAGNGIDSAISSTRIFRLSGTLLPLDTTSTGNAMWLRFTSDGSYTKSGFSLSARSFGSSGKSAYNYDYLEVGNGRNSTDSSSRVFRRSGRILPPDTPSTGNAMWLRFTSGSSSTSSGFFLSARSVGSFGCILNSCLNGGTCRPIGWSGFNCECLDGFEGTRCEIELINLTENNSAIISSPSYPSNYQNNLDIQWVIQTAEDLRILLSFLAFDTQYNYDYLEVGNGRNSTDSTSRVFRQSGRILPPDTPSTGNAMWLRFTSGSRSTSSGFSLSARSVGSFGCILNSCLNGGTCRPIGLSGFNCECLDGFEGTRCEIELINLTEKKSAIISSPSYPSNYQNNLDIQWVIQTAEDFRILLSFLAFDTPYNDYLEVGNGRNSTDSSSRVFRRSGSILPPDTPSTGNAMWLRFTSGSRSTSSGFSLSARSVGSFGCILNSCLNGGTCRPIGLSGFNCECLNGFEGTRCEIELVAAKATIYISSPSYPSNYQNNLDIQWVIQTAEDFRILLSFLAFNTQYDDYLEVGNGRNPTDSSSRVFRRSGSSSPPVTLSHSNVMWLRFTSGGAGTRSGFLVSAESVGPIVRIGATVAHPAAPTTIPAATTKVVKKGCTAPPKLNHVTIAEGQDHVFEPGEVATFTCSVDFVVRGTDRHYAERVCQSDGSWSSKPVECSPVDDPRANETLVGKAAGGGVAGGVLFVVILLLGFLLIRRRWRKNNNQRTVRAPGTGIALISSGNTYNDPRTDTNPPPVHETTISGAAAAADAECATENEVNLKVPLLPTPSPPDGPPPSYDYVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3I9</accession>
    <name>A0A914B3I9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070369.1">
        <property type="nucleotide sequence ID" value="XM_038214441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3I9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214441.1">
        <property type="protein sequence ID" value="XP_038070369.1"/>
        <property type="gene ID" value="LOC119739473"/>
    </dbReference>
    <dbReference type="GeneID" id="119739473"/>
    <dbReference type="CTD" id="22985"/>
    <dbReference type="OMA" id="GVKWPPS"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127799" checksum="C5A348EDB9CFD361" modified="2023-02-22" version="1">MWRIFNMADSEDAVPMIDGKSIDSLRVVDLKQELKKRGLSISGSKSVLVERLTAQMYLERLQQESVEDGATKKQIVDESVASNSFIQQYLQQQQELLRQGQTDKEHEQEEERKNCPEVPAALADQVEELHQSLSRAQSQEDDAPETEKPQPEESPAAESSNELAAADSTQEPPTVEEQKTGKEAGKEMEEVKVKEGKEVEAEPEKSEAAREQSKEVHEDAPQQEQDIQEQVIQEQEKDDKEGKGVGNEVDTSRPSEDQSGETGSQQEDLSKTSEETVGETKKSEDGGDVKASAPEPDQEPSPEPVAAPKRGRRWSSKSSEKDETAERGEGRVSRSSLRRSSRSRISETQEEEKAAKKDDEVPEESASPRALEQSGNQEAVTESKDVDAHSTDGDKGIEDVQGVGKQDQEKTPTEEKVSDQPMETDEGSPEKQDRLEETKPGRLEETKPGRLEETMPRRLEETMPGRLEETTPGRLEETMPGRLEETMPGRLEETKPGRLEEPKPGDENASAAETSTVTEQSSEEPTKNEQVQNKDETDQVEEPVAMETEEVAESRNDESADNVVKEKSDMVTSEKKIPVEEVDKSSKPPPVAVKTRRIALGSSKDKEDGPSDKTSPGVTPPPTRKRRWGTTKNLTQQTKKLNVNISTDMLKEMMPEMKQTSIDSVTMETDDKRSSSSESSDEDDGEPAPKRKEPTITRTITQVVAQEELDGSEGSSDEEGQAERQSKEENGKADSSGDEGDEKANKSSGEDNDSSDSDGDSDPGEDTQKASDGEKEDGKTDEERRDEKEERERLAKEKAARREEREAAKQKAKMERAKEKEEKAQETLRAKKTKLREVVRTSIDDPIRVDGRPSKPSPSRKPESNIVHVMNLVRPYTLNQLKELLGRSGSLQAQDGFWIDNIKSHCFAVFNTVEEAGACRDSLHGTKWPSSNPKTLRVDFATIEEMDRHTGRSIPKPEPKPEPSPAERPKRERRASEKEREGPDKDRGGDRARERERDRQGRPPMREWDRDRERSLSRERRRREREKRQAEQKAKEEAEEPPAKLLDDLFRKTKSTPCIYWLPLTEEQIEQKVQEKKARVLDREERRKKMEVEEKEREQAAKAEEQQQKQQQRSGGGRRRSRSRSRSRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4V4</accession>
    <name>A0A914B4V4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="RefSeq" id="XP_038071103.1">
        <property type="nucleotide sequence ID" value="XM_038215175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4V4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215175.1">
        <property type="protein sequence ID" value="XP_038071103.1"/>
        <property type="gene ID" value="LOC119739995"/>
    </dbReference>
    <dbReference type="GeneID" id="119739995"/>
    <dbReference type="CTD" id="36"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="73"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="295"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="49348" checksum="9FFA2AAC69C5FC3A" modified="2023-02-22" version="1">MAARLLNRVRQHLPRVSKLSCRADLKNTPPSCHQLRNIITPLARRLTTVADPSQSYAAASGHQAGRLPATQLSEEEQLMKDMVAKFAKEQIGPLVREMDDRGETDMGIIQAMFDNGLMGTEIPESYGGPGASFFQSNIIVEELAKVDPSIAVCNDIHNTLIVTLFLKYGTEDQKNKYLPMLMADQVGSFCLSEANAGSDAFALETKAVQDGDFYLISGSKMWISSAAFAGVFLVMANADFSAGYKGITTFIVDRDTEGLTVGKKEDKLGLRASPTCEVHFDNVRVHKSQVLGQVGHGYKYAIGMLNEGRIGIASQMVGLAQGALDSTIPYLMERKQFKQALWDFQAVQHQVAHLSTQVEVARVMTYNAARMKDAGQSVIKEASMVKYFSAEVATEVTSRCVELMGGVGFTKDYPVEKFYRDCKAGCIYEGASNIQLNTIAKCLQSELAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4Y8</accession>
    <name>A0A914B4Y8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071137.1">
        <property type="nucleotide sequence ID" value="XM_038215209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071138.1">
        <property type="nucleotide sequence ID" value="XM_038215210.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215209.1">
        <property type="protein sequence ID" value="XP_038071137.1"/>
        <property type="gene ID" value="LOC119740021"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215210.1">
        <property type="protein sequence ID" value="XP_038071138.1"/>
        <property type="gene ID" value="LOC119740021"/>
    </dbReference>
    <dbReference type="GeneID" id="119740021"/>
    <dbReference type="OMA" id="WSLKATY"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="53"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1715"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1812"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2044"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1526"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1815"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1874"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1902"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="2058"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2069" mass="236635" checksum="D119F1D3DA037DA2" modified="2023-02-22" version="1">MADITCTSFDDLYDPENDEVDETRPDIRKNLLEDFAAPTAKLTRESVAHSREHMQVHLRIRPFTNREKEQGESQDCMEISQPTSLLMRAPKDSFTFKSSQRGFSNMTHKFTFSRIFGEDTSQKEFFDETMLGTVKDFIDGQNCLVFTYGVTNAGKTYTIQGVPQDGGILPRSLDVIFNSLEGRLFPSLQLKPRFFCDVAKLDERQRKKEEYIKDSVLSMAEGNSNKQEGTQDSSGMDEADDSRASSYTTATEDSQSEISVSSITDDASMPNVLDDINSRIPDDTSVDVEAQGPLKFSVWVSFAEVYNEYIYDLLEAIPKAKKVRRQPLKFSEDKNGQIYIKGLKEISVQSADEAYKILKIGQQNLSMAATKLNHCSSRSHCIFSIKILRVVDVENPHVARVSQLSFCDLAGSERYTRTQNTGDRLKEAGNINTSLLTLGKCIHTLRYNQNHPKSNPKIIPFRESKLTRLFQSFFMGKGKASMVVNVNQCASGFDETLQVLKFSAIAKQVTTVTSKLDNKWKVPAAGGPKLASSRALSLALRQSLSRNRASVAWATPGPQLDSNLDLTTVDESFEEDEDDEEDDEEEEDGERTPRESMVNEESRAALINLVEMLKTQLIEEKKRMMMLEVQIREEVCQEMAQQLVQIEGDYKDQLEKERLTTEEMFEKRLEMYEKSVKTTRKRPRPDDEEEYVSSLLLHAEQTKVQNQEKINEGLRQDIETLKEALEESHEKMSSQDETLTELQRLTEESKQALREAEAKLCAKDEKLDALLHKIQELEDIHKDSRQKLEQETSDKEKVAAEYERSLALKSHAIEELEDTNEELEDANRRLQQQLGLTEKLQTQLSQSESTLKDTYQVIQTLEQDIDKLKRQLEDSENELSESKVHPVDCPDKLHAEKLQKKVTALEKEIQEQVASKEETLDKWREEKDNLVNALEQMEHRMTSLLETQKNNEAVLAEKDQQNEHLETQLSQSESNLKDSNLIIEALEQDNDKLRSQLEDSHKQNEAALADQNEVSDLKAQLSESESTLKDSNQVIKTLEQDIEKLRSQLEDSQNELIESKNHRVDCPDKLQAKKLQEKVTALEKEIKMQVASKAETLSNWHEEKDSLVNTLEQMEHRMTSLLETQKKSESASSEKDERIQHLETQLSQSESSLKDSNQVIRTLGQNVDKLRSQLEESQKQNEAAFDEKVKRIEDLETQLSQSKSSLKDSNQFIKTLEQDIEKLIGRLEDSQKQNEEVLTDKDERIKDLETQLSQSKSSLKDSNQVIKRHEQDIDKLRNQLEDSQRQKETAFTDRNGRIEHLETQLSESESTLRDSNQLIKTLEQDIDKLRSRLEDSQRQNEAALADKNEVLKDIKMQLCDSKSNLKDSNQVIKTLEQDIDKLRSQLENSQKQNEAALAEKDERIKDLEMQLSQSKSTLKDSNQVIKTLEQDIDKLRSQLEDSQEQLSESKRHPADCPDKLQAEKLQKKVTTLEKEIKELVDSKEETLARWREEHDSLVMALDTRVTSLFETQTENEAALSEKDESIQHLKTQLSQSESTLRDTNQAIKILEQDIDKLRSQLEDSQKQNKAALADKDEHVEDLEARLSQSESTLKDSNQVIKTLEQDIDKLRSQLENSQKQLIESKNHPVDCPDKLQAEKLQKKVTALEKEVMKQVASKEETLNKWREDRDSLVKALEQRMTSLLETQEKNEAALAEKDAHIEQLKTKMIENISDSQSVTDDESYIEDTSSTKTKGRSRKGRGQTSNVQGELQREVQQLREQMEKERNAKEKVVAESKRNLVLKSHAIQELEDANRHLQQQLGLIEVTVDVKRLSRSSSESSTTTRQSAPSSSPQPDPDSPDLFIVDVKDQESFHQPGRRRTRVELDLTPLQKKQPARKTRANTRKARKRKSTELLEEIDMDAYQKRSRPEEQSAARPVRSTRKRNTRANRGETDLDQDENTLAAETPSASNRGKRAALSRIGDLLQNTQFAKSAASKSKLSSRSQTSAKKLVESAAAHMTSPTKSPEVQEVAYYPPPTTEKKRKRRLLKTDISVPFESSPFEVLNAGESKSDNSHSIVTRKLRSRNTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6A2</accession>
    <name>A0A914B6A2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070992.1">
        <property type="nucleotide sequence ID" value="XM_038215064.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070993.1">
        <property type="nucleotide sequence ID" value="XM_038215065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6A2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215064.1">
        <property type="protein sequence ID" value="XP_038070992.1"/>
        <property type="gene ID" value="LOC119739925"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215065.1">
        <property type="protein sequence ID" value="XP_038070993.1"/>
        <property type="gene ID" value="LOC119739925"/>
    </dbReference>
    <dbReference type="GeneID" id="119739925"/>
    <dbReference type="OMA" id="PFEEYMW"/>
    <dbReference type="OrthoDB" id="5985142at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040396">
        <property type="entry name" value="PAIP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154:SF6">
        <property type="entry name" value="GEO05078P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13154">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="169" mass="18124" checksum="7E9E26454AE19C22" modified="2023-02-22" version="1">MEKSSTGSGDGAENDPNKDKDTAAMTTSNEQDNPFAEYMWMGDPKEEDEVNLQVMEEILEEEFIESCFEDMLEEEALGLFTPPGEEPGGDGDDEIIPALHSLSLDENDAVADLNAVVDVESRDDENQDHEGDGWRGGANGSTPSGFGGQGSDGESENSDADSLGDTPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6T2</accession>
    <name>A0A914B6T2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071525.1">
        <property type="nucleotide sequence ID" value="XM_038215597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6T2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215597.1">
        <property type="protein sequence ID" value="XP_038071525.1"/>
        <property type="gene ID" value="LOC119740331"/>
    </dbReference>
    <dbReference type="GeneID" id="119740331"/>
    <dbReference type="OMA" id="FATIQWF"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037596154" evidence="6">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="248"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="43602" checksum="1FDBB7C6648457A9" modified="2023-02-22" version="1">MAFRDGALVVVLGLCLLYVKGGAGVSTAESQDAQHDSRHDLIAKLMEVHNKLVMPKTPVNVSYGLTLLSIEGVDEKENILRIAAFATIQWFDHRFQWDPANYSGLSFVNLPRNSIWTPDFRMLYAQVVEEDDVNLIAYAGGTVSHFLPLRLAIPCSFNFKDFPSDVHTCDLFLESWSHPGSLINLTFFEDETAASLAYHRVNSQWEAQSFKVNRKVTKYPDYSTEEYINLSYRIQFKRTVKEYTVRFVAPSVVTSLLILLCFLIPPLSGGRMVLCSVVILGLLLQLFHLNQTVPIHGSDAPFMAKFLTFSVFLAAFAAVESVVSMNLSSWGTLSGSSNNNSNAPKDGEELVAQPKPNLFLMQLARIIDLVCFVVFTVIFAIGGGVILNPTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7D6</accession>
    <name>A0A914B7D6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038071352.1">
        <property type="nucleotide sequence ID" value="XM_038215424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7D6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215424.1">
        <property type="protein sequence ID" value="XP_038071352.1"/>
        <property type="gene ID" value="LOC119740210"/>
    </dbReference>
    <dbReference type="GeneID" id="119740210"/>
    <dbReference type="OMA" id="CEFGRES"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000002">
        <property type="entry name" value="Leishmanolysin like peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF6">
        <property type="entry name" value="CILIATED LEFT-RIGHT ORGANIZER METALLOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038158062" description="Leishmanolysin-like peptidase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="765" mass="83906" checksum="E1A2D08AC1121221" modified="2023-02-22" version="1">MTSWFSDPLFWFVTTALVFQCPTEVSCPARGSHQCISDQVQPQTIGKSTLVNYESGRDKRSAAPNLFQPIRITASVINPEGVVDTSDTERLQTIVEGAVSIIRKVLRVVPVSGPLLMARSDEACLVTFTSGTNIGKCAQISRGYVGEKCLDDFLIPDEHLQGLWTWNSTYPHPVHQIYPDGAGLVDTDTALYVKAEHTAQCSSGQTVAYASYCKLDQNNRPIAGVINFCPEHLKDDLYDKPKFILLAVHEIFHVLGFSSSLFNKFKECSESADGLTCIDRCTTTGSDSQGMRRLITPAVTAHAQKHFDCPESGFGGPLENQGGNDGISSHWETRMMYGSIMAPIIDQPHQTFLDNLTLAVFEDSGWYRVNYEYAEELTWGKNQGCEFGRESRCQTTADRFFCNDSSSGCHYLHRDKATCSSNDYLDECRVMKANNQDHCSVPEDGSSSVNGEVFHNNSRCFVSNVVNIESMVDPCDLGGVCYLTRCNNQSTSYEVKVGQADWLSCPNNTAITIPGYHGTVHCPATEIICQQETSILDLVDAECQSCSTTAPPTSLEQKSTPAQPVEHTLCVSLEFGEMDYSIVDGEEQMLVFSQAVVKGICDVADIRKSRIHIQDVAPGSASLEREDLVCVTFDIAEAGESNDTPAHVAYSDLEAAVLSNQMQIQYLNMNYTAVSIRIISIEVPTSTQPQTTTTVRISEGDLSTWIALGACIFIFVVVIVLGCACHRAKRNNAIGPSNDESVESVAGERLAGMAYVVREKTVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B981</accession>
    <name>A0A914B981_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein ceh-24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072681.1">
        <property type="nucleotide sequence ID" value="XM_038216753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B981"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216753.1">
        <property type="protein sequence ID" value="XP_038072681.1"/>
        <property type="gene ID" value="LOC119741084"/>
    </dbReference>
    <dbReference type="GeneID" id="119741084"/>
    <dbReference type="OMA" id="SSWYGAN"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000296">
        <property type="entry name" value="Scarecrow, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="40816" checksum="72B4F3BBB09D560A" modified="2023-02-22" version="1">MSLSPKTHSTPFSVTDILSPLEEFGYRKSMLDPSGNFMTTMQPTYRSPQHSNNMQSSMNVPVSNPYHMHVPQLSHPPLGTTYCNGSVGELSHYNEHVRQSASSWYGANPDPRFSISRLMNPNSPMNMNMNMNMNMNMNMNMSMPGLGGDLSKPMLPSAQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKMKRQTKEKNMADNNNVCHQSPRRVAVPVLVKDGKPCNGSSNGSSSGGSAHDSASPQLGDDAHSTGSDHASSMPGAHQVTAHHVSTTVQQSHMAPPAHKAVPVNSSSSCSGHGVGINTGPGVTSSHSPHHQPGAVNPYHSMNGTNMSSAAPFLLHGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAD0</accession>
    <name>A0A914BAD0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073153.1">
        <property type="nucleotide sequence ID" value="XM_038217225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217225.1">
        <property type="protein sequence ID" value="XP_038073153.1"/>
        <property type="gene ID" value="LOC119741467"/>
    </dbReference>
    <dbReference type="GeneID" id="119741467"/>
    <dbReference type="OMA" id="QSKYLIF"/>
    <dbReference type="OrthoDB" id="5988333at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="41299" checksum="1FC07F0CBF6BCF38" modified="2023-02-22" version="1">MSTHLSADILSLLDGPSDLECSGVVAHADPLPSTCTSLSAAGGNPPVVKAKAKSKKSTRSSDEVTRQEFASLQDKISTMADAMQTLQSTVLASLGNPPTKKQKVDHAVADQAASSSSDESFATGQLIDNLLKSDADDNSSAGVLTAVEQFYSGEDSGNKVDEKLAGVISKLLRKKTSEEKVAEKLNSFKRPSNIPEMDVTRVNPEIWNSLQSKTRSMDIKLQKVEHAALKGMVPIVSCIETLMSNKSVDHKTLVTNLLDSMAIIGHTVTQLNFRRRELIKPDLNQQYSSLCSAQVPVTGLLFGDDLPKQCKDIQETNKLGQKFGQRSSSSAAPKSDRARQRGNAKTFHTYSGQTRQGNSSRPKRWQKRKPAQTRQQSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBM6</accession>
    <name>A0A914BBM6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072832.1">
        <property type="nucleotide sequence ID" value="XM_038216904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216904.1">
        <property type="protein sequence ID" value="XP_038072832.1"/>
        <property type="gene ID" value="LOC119741188"/>
    </dbReference>
    <dbReference type="GeneID" id="119741188"/>
    <dbReference type="CTD" id="51187"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="165" mass="19663" checksum="2C51E1695C36581F" modified="2023-02-22" version="1">MRIEKCYFCSCPVYPGHGIQFVRNDSKVFRFCRSKCHKAFKKKRNPRKVRWTKAFRKAAGKELAVDNSLEFEKRRNVPVKYSRELWKKTILAMARVEEIKKKRQDQFIINRLKKGKTLRKERDIKEVKESIHLIRSPAANLLKKKEEKLMQVIPDANPEKMETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDL8</accession>
    <name>A0A914BDL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074154.1">
        <property type="nucleotide sequence ID" value="XM_038218226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218226.1">
        <property type="protein sequence ID" value="XP_038074154.1"/>
        <property type="gene ID" value="LOC119742187"/>
    </dbReference>
    <dbReference type="GeneID" id="119742187"/>
    <dbReference type="OMA" id="YVMILTA"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="440" mass="47130" checksum="CA0C808642ECAE8E" modified="2023-02-22" version="1">MGCLSAQVRSGWCAVLSLHMTWLVWTGLIKGLGVMLPVLQEEFQSSTWLVGWTIAIINGISDFVGPFAGPLEMKFGPRMVIMMSGVLIGGSLVVASLATSVIQFAVSLTLLSGCGISFANILTRAMVGRYFTTHYTAANGIGHAGHSVALIVFAPLTQLLLDTYGWRGAMLLLGGICMHLVPCGTLFTDRPTSQRHGGASGDEYAPLPGDSESPPQSSKCCCCCCLELQFSGARCALNFGLEVFEKASFYLTAVLFISNRLVNDLWVIYFVDHVYAKGLSGQDAVTFTAAAGVANLVAKVAHGPVVDRGWMGLRTMMVVTITVAAACLFADPWMDTYLWLMVNAVVFMGASGVIGALLDVYTKDLLGADYLVSAFSWMGVLSGFATTSLGFLPGWMYDVSGSYDGAFILMGGIWSVSLVVMVMEGVMYKLGWITRDSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI67</accession>
    <name>A0A914BI67_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075978.1">
        <property type="nucleotide sequence ID" value="XM_038220050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI67"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220050.1">
        <property type="protein sequence ID" value="XP_038075978.1"/>
        <property type="gene ID" value="LOC119743669"/>
    </dbReference>
    <dbReference type="GeneID" id="119743669"/>
    <dbReference type="OMA" id="FHHPHCS"/>
    <dbReference type="OrthoDB" id="8963449at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492">
        <property type="entry name" value="SI:CH211-171H4.7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37492:SF4">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="46253" checksum="91EEF4DB47F67C43" modified="2023-02-22" version="1">MLHHAPPCPTVPHRATPCSTVLHLAQPCSTVVHLIHLAPPCSTVLPPCSILLHRAPPCSTVLHLAPPCSTLLHRAPPCSSLLHRALPCFTMPHLAPPCSTLLYLALPCSTLLHLAPPCSTLLHRAPPCSTMLHRVPPCSTLLHLALQRAPPCSTMLHLAPPCSTVLHLAQPCSTMLHRAPPCSTVLHLAPPCSTMLHRAPPCFTMLHLAPPFSTLLHLAPPCSNMLQRASPCSTFLHLAPPCFTVLHFTPPCSTLLHLALQRAPPCSTMLHSTPPCSTVLHRAPPCSTVLHRAPPCSTVLHRAPPCSTLLHRGPPDPPCSTVLHRSPPCSTLLQGAPPFSTVLHSTPPCSTLLHRAPPFSTLLHLAPPCSTLLHRAPPCSTVLHLAPPYSAVLCSTMTYNPLTFSTFQGDTCVEKKGTRNGRWHKKGTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJP3</accession>
    <name>A0A914BJP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Syntaxin-binding protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076135.1">
        <property type="nucleotide sequence ID" value="XM_038220207.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220207.1">
        <property type="protein sequence ID" value="XP_038076135.1"/>
        <property type="gene ID" value="LOC119744334"/>
    </dbReference>
    <dbReference type="GeneID" id="119744334"/>
    <dbReference type="OMA" id="IVWKFFD"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000521">
        <property type="entry name" value="syntaxin-binding protein 5-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="1063"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="445"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="690"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="855"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1128" mass="123310" checksum="1AEE3EBF41056E67" modified="2023-02-22" version="1">MFLVNEGALVSVCADDSLHLWNLRQKRPAILHSLKFNRERITHCTLPFQSKWLYIGTERGNVHVVNIESFVLSGYVINWNKAIELSRKTHPGPVVHLSDNPTDANKLLIGFETGVVAMWDLRTRAAEQRFNCTQPVRCISWHHDGKQFIVSHTDGTLTTWNIKSPTKPANIISPHAKVPAKGLKPEPCTPVLKVEWRSVKNGDPFILFXGGLPYEKASSTPSITIMQGKTTTVLEMEHTVVDFLCLCDNPWPSNPQEPYAVVVLLESDLVVVDLTSPGYPCFENPYPMDLHESPVTCVQYYADCPSDLIPHLYSAGSNSLNRKKQLYSKKNWPVKGGGWGSGGSSEQEIVITGHADGTVKFWDSSQVMLQVLYKLKTAKVFEKQKQARSLDGDEEPFAIQMVKLCQESRLLAVAGASGHVILYRFSRLEVTTELPVLEIAILYEPEEPDTPEAETPPPPPTPLKRNTSTVSASSVASAISSPPPTQTSQASSGGATGASGSSTGNQATSTSSGEGIRDNVPNLKVKGGPHKRASGFQPDLCCQLVWVDGEAPSTITTVEINSCYGLLAFGTITGLVIVDYLQKTCLLNMGTPDLYGSADPYTRTPRSPKKNKPQGLGDIVEQYMADPERCKSPTSSSAEQQNGVCVSPTSTNSSRKQGRNNHDPAQLKRSKSQGSRKLISCKAQSVCSDSGNCGPGEAPPNGSPPTPPPSPKEGPKEVNPAHSHFSQLIKFVVTGLSMNPSVLHVPYRSEGSFTRSRSSSMSSLEKEAREGVQCLTFAESYTRKTESVTSPCIWVGTTLGSVLVIVINLPPWGEQRYTQPVIVTPSGTILRLKGSTLLMAFLDCNGSLITPPYEPWKDVNKDTKESRDKRPPSLQRSRMSPSSSTEIADRQFVIICSEKEAKVISLPSQTCAYRVKVAESSYVVRTDVISLQNSVCLACYVANGHIMAFSLPSFRVLLDHDYLPLTDLRIGRTFQFSSHGKGIYQASPTELQRITICSEASENLHDMLGDLFLPVNTPEAPSKGFFKGLFGGGSSTLDREDLFGESSGKPSRSIARHIPGTGGIEGVKANSSSAAGELYKARIALHERGEKLSELEERTAQMMANAENFSQASHQLMQKYKDKKWYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJY9</accession>
    <name>A0A914BJY9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075762.1">
        <property type="nucleotide sequence ID" value="XM_038219834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219834.1">
        <property type="protein sequence ID" value="XP_038075762.1"/>
        <property type="gene ID" value="LOC119743435"/>
    </dbReference>
    <dbReference type="GeneID" id="119743435"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000498">
        <property type="entry name" value="Striatin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000001">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000058">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="722"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="800" mass="88427" checksum="8C8341FB393FF230" modified="2023-02-22" version="1">MENDTGPPQNHINQMNSGNANVMNSLPNKQHDDNQRMNYTIPGILHFIQHEWARFEMERAQWEVERAELQARIAFLQGERKGQENLKHDLVRRIKMLEYALKQERSKYQKLKCGHDLSQEIKPPTFDGEEGGEEESALSPNSQINFKQSRQLLRQYLQEIGYTDTILDVRSNRVRSLLGLAPNEQNIPGLDGNMSIEPVMNGESPVKQGRQSDTAKRQDKKHPMPENDLDTVLTSFSFLDGTDDEEREKELGEGRMMGEDGILEGRSKMGTIIKKKKPVVGNESMAGMDDVLNDPATEEALVEFDLILSEASEGAGEARTAGDGADWGLDKKSDLSPTGEEWGVDANTISKLKEEYKKSRKDKKFVQRPKKTALQAMLANLEGEEEPPPPSHILMPERPRGVIPSIDMPDDGVAEDMQGGVGMGGRRPMMNIGDEESIEAALGLGELAGLTISNEADALSYDITANKETFRKTWNPKYTLRSHFDGVRTLAFHPAETVLITGSEDHTLKLWNLQKTVPAKKAASLDVEPIYTFRGHSGPVLSLVISSNGEQCFSGGTDAAIRCWNIPGSNIDPYDSYDSGVLADTFVGHTNTIWGLAFDGTKNQLVSCAADGTVRLWAPQNKSPLLSTFKTETAYGNPTSVDFVRCDSSQIAVGYQSSDTIIFDLETGAPVVTLESKMPSDNAYTQINKVASHPTLPITITAHEDRHIRFFDNTSGKMVHSMVAHLDAVTSLAVDPNGLYLLSGSHDCSIRLWNLDSKTCVQEITSHRKKFDESIYDVAFHPSKPYIASGGADALAKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLB4</accession>
    <name>A0A914BLB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein KIF24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077083.1">
        <property type="nucleotide sequence ID" value="XM_038221155.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221155.1">
        <property type="protein sequence ID" value="XP_038077083.1"/>
        <property type="gene ID" value="LOC119744936"/>
    </dbReference>
    <dbReference type="GeneID" id="119744936"/>
    <dbReference type="OMA" id="QHRVCIA"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="282"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="861"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="928"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1368" mass="150824" checksum="D39F6E108CAC5CB2" modified="2023-02-22" version="1">MVNGLSDCLQEANLAQYTDNFLQLGVCSVDTLSSLTIQEYPRFGITDLADKKRLFRLVHIVKRVKADKGRAPDVDSQKRKTSHLKQLLPCDNDHQYTQQRDDMQTDLVPPQSALKNLEKSPTPKGPGVSSKDNSQGLKGQRSSSQLKGTDSLLSVARQELKAGVLSPSTVRKLETTGGILFVKPTSASPKVHPNNRLKHSSARKRLVLQESLSDSEISYSDSPDGSSVAVDRTNFGAPQILKKSFIEVIDHGDNSVYNYGVPGQPIKQHGTPQSSGQNEAERIKVCVRKRPLSKKEERDKEKDVIQMEGRGTLVINEAKVAVDLTKFMQVHKYHFDETFGESCSNQEVYAKTAKPLIATMFNRGKATCFAYGQTGAGKTHTMLGNHGVKGLYLLAAEDIFNTLNASGQSGKELAVWASYFEIYCGQLFDLLNERQRVHAREDAQHRVCIAGIKEVHISGPQTLMQVVEQGNKQRSKGVSGVNADSSRSHAILQLQLQDGGRRKLGRFSFIDLAGSERACDTADPDKVTRYEGAEINTSLLALKECIRALDQEQRHTPFRQSKLTQVLRDSFLGHSKTCMIANIAPNSSAVEHTLNTLRYADRVKELKKETSSQQPVSPYPSTPNTFSPGTTSTPVKMLKKQLPSPKVAHQSPSVRKVTPVKTVSFEKSADKSGCQQKDPRSMRKLDENQNGVFNSRRNIGHGDRKNTETPARKPMPRINDAVNQSQNSSRRSSTGKKGPSVSPDSLKNNSEMQSKRSEEAKVHTKEAFLHGQSLPVWYPPEEPEKAKVQTKTVGEAWEVENPRYAHSPKMQKADLGARTSLRDTTEGALGCVSSAESKSAISTQKFDQQVGYISASEAYAADQESGFSADDEMTRTRSRRNDSSAVKHSLQSRLSETSCSTDTDSTMELLAEIDHALRNSLVSPVDDNKLAGGYPSHGLSHGKYDEKARSSQRSRTRSAPTPEQFPKHQNVPITTNNETSPVNHPEVCIKRQDPKTDTPINNQLYKASKADTTSPNHAQTRSVVNRRDPVASQSPSGSFRSKLTVKGIESLPSPRDVQRTTSQSVGGPNQEVTDANEAVDSSQWLEQPAKNIENQSGVIVSTSFHDYVSSTGSYQPSQSEPSAIQTPEHLKIRGYRGLSSNPRNVLQSPVTVEVLRSESRPSAFHPVSDFAGGNTSSSVSSKPVPAKAFTKESLSSSVHQELIRSEADFQQSPIAKEKVLVRHNHDDWLSSNLPSNSSSQGRGFTVREGVIEGLVPRLQLPNMMTSSTDDVSQDLLLPRQNSAMEKATELLVSAHAEQIDELQRLCEREWRLIKQLHNGEKGLSEYLSYARDLMSSKLRCIDTFQDQLSTFRCSTPNVSPRSGSPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM06</accession>
    <name>A0A914BM06_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neuralized-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076502.1">
        <property type="nucleotide sequence ID" value="XM_038220574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220574.1">
        <property type="protein sequence ID" value="XP_038076502.1"/>
        <property type="gene ID" value="LOC119744577"/>
    </dbReference>
    <dbReference type="GeneID" id="119744577"/>
    <dbReference type="CTD" id="140825"/>
    <dbReference type="OMA" id="RIGIIYV"/>
    <dbReference type="OrthoDB" id="10059069at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33632" checksum="7A9FF6AAB09C64D9" modified="2023-02-22" version="1">MPLIRFHENRGINIELKHDNQVARRSASFANAITFSDRPLRPGELFLIEVEEQEPGWSGHLRCGLTQHHPASLKVIRPGDRVPNRSPSEFHQRRGQAARVISAPQPLTIPQYSMPDLTNMGKSWVYAITKYHNKVPDERLSTAEVEALARSEFVKDGVNVLKIGCAEIPRHLLVQDFIALDQEASWISGQQQYFATSVGSRIAVTYNILGDKVYMHFIINGEDQGASLMEDAHLDSPFYGIVDVYGTTKQVRIMQLIYVPSLQECCRHSIRSMTPDNLLQELPLPNKLNRYLQYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNP9</accession>
    <name>A0A914BNP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038077756.1">
        <property type="nucleotide sequence ID" value="XM_038221828.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077757.1">
        <property type="nucleotide sequence ID" value="XM_038221829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077758.1">
        <property type="nucleotide sequence ID" value="XM_038221830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077759.1">
        <property type="nucleotide sequence ID" value="XM_038221831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNP9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221828.1">
        <property type="protein sequence ID" value="XP_038077756.1"/>
        <property type="gene ID" value="LOC119745468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221829.1">
        <property type="protein sequence ID" value="XP_038077757.1"/>
        <property type="gene ID" value="LOC119745468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221830.1">
        <property type="protein sequence ID" value="XP_038077758.1"/>
        <property type="gene ID" value="LOC119745468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221831.1">
        <property type="protein sequence ID" value="XP_038077759.1"/>
        <property type="gene ID" value="LOC119745468"/>
    </dbReference>
    <dbReference type="GeneID" id="119745468"/>
    <dbReference type="OMA" id="MATEMHA"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="331" mass="37547" checksum="8141FB59F009E79C" modified="2023-02-22" version="1">MKMSDLDELTQRFSSQSSAEKFEAADTPQQVLDEISLEGVARYIQSGNCKNVIFMTGAGISTSAGLPDFRTKTTGLYDQLEEYELPNPQRMFEIRYFMERPEPFFKLVKSLYPGDYKPTPCHYFIRLMSEKNVVLRNYTQNIDTLDKIAGMKDELIVEAHGGFSTAHCIGKECYTEYGQKWVRDEIFADRIPKCNNCGAIIKPDCAFFGEDMPKGFDKLVEEDFPKCDLLIVSGTSLMVQPFAAMINKVPATTPRLLINYELSGKIDPLMKFMGTSVGFNFDYADNYRDVFYLGSCDDGFYKLAELLGWKDELVQLIKTEHQKLDAAASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPH7</accession>
    <name>A0A914BPH7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078043.1">
        <property type="nucleotide sequence ID" value="XM_038222115.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078044.1">
        <property type="nucleotide sequence ID" value="XM_038222116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222115.1">
        <property type="protein sequence ID" value="XP_038078043.1"/>
        <property type="gene ID" value="LOC119745620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222116.1">
        <property type="protein sequence ID" value="XP_038078044.1"/>
        <property type="gene ID" value="LOC119745620"/>
    </dbReference>
    <dbReference type="GeneID" id="119745620"/>
    <dbReference type="OMA" id="HPWTDKC"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="473" mass="53173" checksum="ADD7A16CE982AA54" modified="2023-02-22" version="1">MVAPSKIWKVCSCYEMCHCWNPSCIGASWDIAKASYKFSFRTYVIFYTISTLIFHKGIPDVRKLIVDILRSTNFLASNAILFMSSICVFRRLLGRFFAWFVWGPACVASGIAISMEKKSRRAPLALYMVTLAIELLINIVLSRGWVKPIKYGEVMLFSVSSALGLFLFRYGNVLKNDSLSALKMLVGAQELPVELQPDEVRLPIASQENGTQHEGIQRTQRPTFMSALQETLKTKCLQFVDRLKSLQKHRLCQHQSSCIYYVLQACIRKFAVGYAVQAALNLLRALPKIATRPGLLLQAFVRQDNFGLALFLSLFVAIFRSLSCLLRWLRNKDSPLHALIAGGAAGVSSIFYRSTAISLYFASKILENLIVKGQERGIVPVIPRAPSILFALSTATVLHAGAYEPHNIRPAYWSFLLNLTGQRYGDMNRMLIAHLGTDSTRIYPDWPVYPDLSKLKLVDKDGLCVQSLQPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSY9</accession>
    <name>A0A914BSY9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079085.1">
        <property type="nucleotide sequence ID" value="XM_038223157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223157.1">
        <property type="protein sequence ID" value="XP_038079085.1"/>
        <property type="gene ID" value="LOC119746294"/>
    </dbReference>
    <dbReference type="GeneID" id="119746294"/>
    <dbReference type="OMA" id="VESENCM"/>
    <dbReference type="OrthoDB" id="6145467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="526" mass="60232" checksum="8D5770A6E13CE2EA" modified="2023-02-22" version="1">MIPFYETPPHTPNVEKSKQGLNNRSAINNSEFVTNAISDLLETHCVLPCTEQPYIVNPLSVSVQKSGKRRLILDLREVNRFLWKLSVKYEDMRTAMLYLQKGGFMFQFDLKSGYHHISIRTEHQQYLGFSWFYKGAFTFFKFTVLPFGLSTAPYVFTKVVRPLVQKWRSEGKQIVVFLDDGLCYAESFQKAREHSAQVKVDLVNAGFVPNVQKSTWDPVSETEWLGLIIDLKNGSLVLPNRRINSIKERIQELLITPKSAGSSTCVKVKDLASVAGCIVSSYLVVGSMSRVMTKAMHCVIESRNSWNSKVVISEQANEELLFWLHNIDNLKEIPIKLTPMCSTMVFSDASKNGFGGYIVNVNDSISHGQWSENERKHSSTWRELKAIDMVLASQINMFKNTRVKWFSDNQAVTRIVCKGSMKSDLQSIVLNICRNCVRNGVFLELEWVPRSKNEKADFISKLVDYDDWQTSDEMFSLLDHMWGPHTIDRFASYYNSKLTRFNSRFWNPGAQATDAFTQDWAGENNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075FGG2</accession>
    <name>A0A075FGG2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-actinin</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Curr. Biol." volume="24" first="1421" last="1428">
            <title>An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.</title>
            <authorList>
                <person name="Mori M."/>
                <person name="Somogyi K."/>
                <person name="Kondo H."/>
                <person name="Monnier N."/>
                <person name="Falk H.J."/>
                <person name="Machado P."/>
                <person name="Bathe M."/>
                <person name="Nedelec F."/>
                <person name="Lenart P."/>
            </authorList>
            <dbReference type="PubMed" id="24909322"/>
            <dbReference type="DOI" id="10.1016/j.cub.2014.05.019"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KJ787016">
        <property type="protein sequence ID" value="AIE90093.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075921.1">
        <property type="nucleotide sequence ID" value="XM_038219993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075FGG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219993.1">
        <property type="protein sequence ID" value="XP_038075921.1"/>
        <property type="gene ID" value="LOC119743574"/>
    </dbReference>
    <dbReference type="GeneID" id="119743574"/>
    <dbReference type="OMA" id="QQRWITV"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="140"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="742"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="784"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIE90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="889" mass="103056" checksum="731AC2A37868B378" modified="2014-10-29" version="1">MSLDEETYMEQEEDWDRSTVLDPMWEIQQTKTFTAWCNSHLRKSGTQIEHIDKDFCNGLKLINLLEVISGERLPKPEKGKMRVHKISNVQKALDYIMSKGVRLVSIGAEEIVDCNLKMTLGMIWTIILRFAIQDISVEESTAKEGLLLWCQRKTAPYNNVRVQNFHTSWKDGLAFCALIHRHRPDLLDYNSLSKDDPKKNLELAFEVAEKYLDIPKMLDPEDIINTAKPDERSIMTYVSCYYHAFAGAQQAENAANRLCKVLRMNQDNERLMDEYDRLASDLLEWIKRKRPWLEDRTLSENSLPAVQDKLDEFRNYRGKEKPPKTEEKGQLETNYNTLQTKLRLSNRPAYIPQEGKMVSDIAKAWKGLEQSERGFEDWLLAEMRRLERLDHLARKFRHKCEIHEGWAEGKEPDLENNDYSGIKLNEIYALKKKHEAFESDLAAHQDRVEQIAAIAQEMNLLEYHDIGPINSRCQTICDQWDRLGNLTSARRQTLETIQDLLQRVDSLFLDFAKKAAPFNNWMEGASEDLVDVFSVHTVDEIRGLIQPHEEFKATLNDAQSAFDELVEIGNKIKNLFAEHNLDIDKSNPYTTLTVQDIVSKWQEVLKLVPERDQALQSELLKQESNERLRYQFAKKANVVGPWIEGQTMKVNNLHMERGALEEHLASLQRIERDVVDYKAHMDELEMYNQSVQEAMIFENEHTKYTMETIRVGYEQLVTTTRRLINELENQILTRDSKGITEEQFEIFRQSFNIFDKNHSGKLDPMEFKSCLVSLSMAPPDDKSGRNPEFDRIMQSVDPNHDGHVTFEAFLDYMSREATDTDTSEQVKGSFKVLAGNKNYITKEDLMRELPPDQAEYCIARMAPYQGPDAIPGALDYLSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZP7</accession>
    <name>A0A913YZP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038045048.1">
        <property type="nucleotide sequence ID" value="XM_038189120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189120.1">
        <property type="protein sequence ID" value="XP_038045048.1"/>
        <property type="gene ID" value="LOC119719621"/>
    </dbReference>
    <dbReference type="GeneID" id="119719621"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="120"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="298" mass="34039" checksum="215FBE37B9D3B3EF" modified="2023-02-22" version="1">MLVQAFSTVTRQASRSLKTTICLKCSLLPNHTARISTKGPRICTSHSQFSEKKFSDLHNCSLDLGTKATRIRGMASIDSLDETQVKLLAEECIVVDRDDKVIGSASKKDCHLNENIDKGLLHRAFSVFLFNEKGQLLLQQRSDAKITFPGYWANTCCSHPLSFPEELEESDNLGVRRAAQRKLKHELGIEAQQVPLDDFHYLTRIQYQATSDEKWGEHEIDHILFIQKEVDVKPEPNEVQNVRYISPNELEGFLKSSETNGTKISPWFRLIAQTLLPDWWKHLDNVKSLEDHGTIHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z098</accession>
    <name>A0A913Z098_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038045092.1">
        <property type="nucleotide sequence ID" value="XM_038189164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z098"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189164.1">
        <property type="protein sequence ID" value="XP_038045092.1"/>
        <property type="gene ID" value="LOC119719666"/>
    </dbReference>
    <dbReference type="GeneID" id="119719666"/>
    <dbReference type="OMA" id="SKFCALA"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="291" mass="34121" checksum="4345DC939B42ED6F" modified="2023-02-22" version="1">MRNVSTFKHSDLNDIMAKEQDRRLTLLKEGCKYFNMSTSGRVDFAHMLVNDAHKLLFNFIPKVSCSTWKGVLSKLRSHNNTGFATLGRYSAEEQNARLANYRKVIFVREPMSRILSAYMSKFCALATRNKPDLQLQWERWFGRDIVRRYRDKKVRTFKEGQFLNITLSEFMTYVCDLGSGIRMSQINDHWLPQHVITHPCQIKYDFIGHFENLSVEGPYVLKWLGVDRFVKFPEYHDSNAVKNLVNYYKEVPLGVIQRMSKYYEIDYKLFGYSVDGTASQLTKSLFGSYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0M0</accession>
    <name>A0A913Z0M0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AKNA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045368.1">
        <property type="nucleotide sequence ID" value="XM_038189440.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189440.1">
        <property type="protein sequence ID" value="XP_038045368.1"/>
        <property type="gene ID" value="LOC119719955"/>
    </dbReference>
    <dbReference type="GeneID" id="119719955"/>
    <dbReference type="OMA" id="YMEATPR"/>
    <dbReference type="OrthoDB" id="10035553at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052655">
        <property type="entry name" value="AKNA_Centrosome-Trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510">
        <property type="entry name" value="AKNA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510:SF13">
        <property type="entry name" value="AKNA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1595" mass="176963" checksum="25E2D9EBFC019CD4" modified="2023-02-22" version="1">MSGTGRDNDSSRPIDSLDSFEHLEGIVNSQSEEDFEPDLPFDVPPPGFHFDRDGFSNDDLENPGSIQEEHLTNESLGGDILHFDDERETSGLLNESELLNNRDQHYDSGSSCPSEDVFYKEGEHLGKGSSMDLLQRYMEATPRANSTSHHQEPNYASDYGDNDRSIEYSDDLFHPNESFHNGHNEQYSDDLPPRASDQIRNHRRNRSNGFVEQERSAGEDSDEISTAPSTELNNTVVANGHFPGKPSAHEVKYEDDPPDSKDSDSASMSLGQFVPNAVNRNRLPRPMGKPSKRSTPKDERDLIRSSKPNDSRQGSVGNRSARSSARNSPRLPATGPLHRGRNSPRYSQRSDDHSDRSRNKQSSTNPNGFRSHARSPIVPRLELRRTSTASSANLSLYSEPSKLDLSLRLQEESKTRQQADELNEQLQKNYDELLGKFARAENTIDQLKLGARVNLYGDSPAPGQSIQGTLSPAQKPGAFVINHPQKATVHHISSSGNRMSGGQMGNQPPNQAGPTSMGVQTNNNNKVGPAGTRPSEMARTSDSDGFPAGEGILMALAFQVRSQQEQIDSFGILLQENQLAPSEQKAVLAQLRTAQGKLEADYMQAKEEHNALRRRNSLLNGGAELTFDPDRSLEGEIFQLGMKLEDLAEIVQNNLNSDPPATLPLPHAYQDEELQRLRQKLERGLQKSRQDEERFSTGDNEQDAAGLQPGEGDSGNSLSPNQSEEEFPSPGDAPSLFSPPKHSRPTNTTKGTERNPKSKVSTDLANGQRRPKQSQHPRPTSLTNKTQNHDPRESSNPRQNGGNTKRNGVPQQKLPDRSVLSPEADSGFMGSESSRQSNQNGGLPGYDGHNQLRRPRDRLTLRSSKLPTGQRSPPQVSRKLMGNWESPGFSDYDISERDEEMDEASTRSAGAGKRRPAAVERTVPAKSTSQTRGRKKPAAVTRAPEKQREQRQDKERHGLQPDGRTGAKYLTNPNKTWDDYRDGPASYPEPTSNYRPSPKQSREPQSLQNGNPREGIDPIRSRDRGPFGVPMGRLRMPPRRGYDSESNVTRSSGKSEAIRDLQGEVERLKYQMAKLSSREKNPRRSPAEEEPRHRTPNPKRSHYDGAGSEAGSSRSEILRALQNEIDDLRNAVNQQTASSPTNDSPMSRTSLRDPPRDEYRPRDEYRDTSYPGSPPSRDGLRETLRQTYIPKTDLPESLFTRTPMRPFLHSSTPYRSHTHNPMPQGSPSYIPEAAPIPASPPRTHTQFQPSRARTSPSQGVTSSPLYTIRQEPCPLCSGSGVQTHGEYYHPHSHHHAVIADSAPHQASAASRPTQYPNPSPSYAPTGVSMPQNQSLHSNPGQQSTLYPQQLVSNQQTVQHPKPVFNPQPVANPVLTQSQPVTFQPQPVLNQPQPVLNQPQPSLSQSQPVLTQSQPILIPATQTPVNQGPNQTTSMQTGVPQVVLTQPATYVPLVTLPVYAGVPVNATQQGTSEKQSRSKSRRKTKSDSQKSTSKPQAVDQSTTIYITPTKRRGRYYVLDDEEIDPSGMEEEMYFRRTPRGSSSKGSSFLRRTKDTKYAHSSSLDLDEAIKMADKLNRSSHRMLETVRSDLSHSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3Y3</accession>
    <name>A0A913Z3Y3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045425.1">
        <property type="nucleotide sequence ID" value="XM_038189497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3Y3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189497.1">
        <property type="protein sequence ID" value="XP_038045425.1"/>
        <property type="gene ID" value="LOC119720002"/>
    </dbReference>
    <dbReference type="GeneID" id="119720002"/>
    <dbReference type="OMA" id="YWPELEL"/>
    <dbReference type="OrthoDB" id="6022170at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35489" checksum="AD9297F7AA2E7C29" modified="2023-02-22" version="1">MEGVNGVEMASTVVVKTYDSTVSAQVPVKEETVLAEDFILTVGKALGLKQSSVKFFGIFQGLLHPCKKFRSIDAVPMNVKDLTIQRWCFDSSKENKLLNDPVATQLIYAQTRTYIEEGLLKPSEELLAELEENKDPSSAAKYIKLCHSIPGYNSVHLPDCRMHKEFGLLPDIKTDSAVNVTLMQRGMLLGVVRESGSDSIEEEYFISWRKIQRWRKHEEDACLVTYSIYSVPSDDYTCLCIHTTQANYLLAATIEMIKGLQSELGGPIFQTSDLVRNRRREVIEWNNIVFSRTRFNAEREIAEKYIEVSMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4M5</accession>
    <name>A0A913Z4M5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046719.1">
        <property type="nucleotide sequence ID" value="XM_038190791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4M5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190791.1">
        <property type="protein sequence ID" value="XP_038046719.1"/>
        <property type="gene ID" value="LOC119720925"/>
    </dbReference>
    <dbReference type="GeneID" id="119720925"/>
    <dbReference type="OMA" id="NEYSCRA"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF120">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="79"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="492" mass="55887" checksum="5ADB9B2168B8E693" modified="2023-02-22" version="1">MACGTQLEYLMRKDHRKCVYGFAWPFCPLYLALIKMDISSEVFNTSDFIADELPSTTSTFRTVCISLVVGLIVLVTTVGNILVIASFVSDRRIRAAMGNWFILNLSICDLTTGVAVLPFNTHWVIVGRWSFGEAFCKLWLIVDFSITHISILSVIFISLDRYWMVTKTSKYRSFLSKKKVQTMTAAAWSVIVIYYTFVALAWAPLTKESPFNYDEDCELDAVLNMYFTIVQIIFEFVLPLIVITYLNLIVYTEIKRRSGGLKRMAHASLKMEGIQAPSKIQSTIKRVRMCSVKPLGIKHDEAMASLDSGSDYDIRQIDSQNSAVATAAENKGPGSACPGDHDSVKTFPYCEQERSVIDTSTVSSHRQMPADVENKRHSIGLTESRKSDRRNQTVTHKEFKKHRKAAITLAALVIVFVICWLPYHITAAWNMICRGCVGDLAWEVVNYMLWCNSTVNPFLYAITNVRFRRNFIRFLGCRRLLRQGRRPVSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4N7</accession>
    <name>A0A913Z4N7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045966.1">
        <property type="nucleotide sequence ID" value="XM_038190038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4N7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190038.1">
        <property type="protein sequence ID" value="XP_038045966.1"/>
        <property type="gene ID" value="LOC119720379"/>
    </dbReference>
    <dbReference type="GeneID" id="119720379"/>
    <dbReference type="CTD" id="23039"/>
    <dbReference type="OMA" id="DCFHELC"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000554">
        <property type="entry name" value="Exportin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000042">
        <property type="entry name" value="exportin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123885" checksum="C28F266D039016A7" modified="2023-02-22" version="1">MADIEQISQLEVLCKQLYETTDAEQRAQAEKALVSFTNSPDCLSKCQLLLERSSSAYAQLLAATTLTKLICRPSTVLPLEQRIDIKNYVLNYLASRPKLPTFVTQALIHLQSRITKLGWFDSEKDNWVFRNIIDDVSKFLQGSVDHFVIGVQLMAQLVNEMNQVRTNPDTVRPLTKHRKIASSFRDSVLFEIFNLACNLLKQASKEGVNFNDENKHALMTQLLRLTHNCLTFDFIGTSTDESTDDNCTVQIPTGWRSAFLDFSTVNLFFDLYKSLPPTLSPLALTCLVQIASVRRSLFNNAERAKFLSHLVNGVRGILESPQSLSGANNYHEFCRLLARLKSNYQLGELVKVENYSEVIALIAKFTIESLQVWQFAPNSIHYLLTLWQRMVASVPYVKATEPHLLEVYTPEVTKAYITSRLESVSAILRDGVEDPLEDKGMVQQQLDQLSTIGRCEYEKTCTLLFQLFDTSAQKYQELIRTNTTGFELATQEGRLTWLVLIIGAQIGGRVSFTSAEEHDALDGQLVCRVLQLMNLTDAKLPQGGCEKLDLAMLSFFEHFTKIYLGNQVQKSSKLYRTLSQVLGLQDESTVLSVFIGKIITNLKYWGQSEPIIAKTLKFLSELSVGYSSVRKLVKLDAVQFMLSNHTSDHFPFLGVNGTFSVGDMRCRTTFYTALGRLLMVDLGEDEDRFETFMMPITSAFEFVGAQLANANDGAVWNEAETKRTLIGLARDLRGIAFAFNNKPSFLMLFEWIYPSYTPILQRAIELWYHEPIVTTPILKLMMELVQDRSERLHFHVSSPNGILLFREISKMFVAYGSRMLTLGADIPKDQVYPMKLKGVSICFGMLKAVLSGSYVNFGVFQLYGDTSLEEVLQMFVKLLLSIPLSDLLDYPKLSLNYYSLLESLAKDHMAFLSGLEPQVFLHILSSISEGLTALDTVVCTGCCATLDSIVTYLFKRISKSAGKKAKKENDNFPSIMVVPPAILQQMLSTVLNIIMFEDCRNQWSMSRPLLGLVLLNEDYFTELRESIISSQPVEKQEDMRMCFKNLMDGIEANLRSKNRDRFTQNLSVFRRDVNDSLKTTNNSSVVSSLSSTDMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4S0</accession>
    <name>A0A913Z4S0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation channel sperm-associated protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046722.1">
        <property type="nucleotide sequence ID" value="XM_038190794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4S0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190794.1">
        <property type="protein sequence ID" value="XP_038046722.1"/>
        <property type="gene ID" value="LOC119720928"/>
    </dbReference>
    <dbReference type="GeneID" id="119720928"/>
    <dbReference type="OMA" id="ICLANQE"/>
    <dbReference type="OrthoDB" id="2159869at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028748">
        <property type="entry name" value="CATSPERB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048789">
        <property type="entry name" value="CATSPERB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053903">
        <property type="entry name" value="CATSPERB_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053904">
        <property type="entry name" value="CATSPERB_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705:SF0">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15149">
        <property type="entry name" value="CATSPERB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22830">
        <property type="entry name" value="CATSPERB_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22831">
        <property type="entry name" value="CATSPERB_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERB head" evidence="3">
        <location>
            <begin position="132"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERB Ig-like" evidence="4">
        <location>
            <begin position="403"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel sperm-associated protein subunit beta C-terminal" evidence="2">
        <location>
            <begin position="505"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="87249" checksum="BBC900A00CE50877" modified="2023-02-22" version="1">MPVTGSYIIIAKTNNITTLVWFSNDGGNDFHQVLFLENNETINGCYLNPHGGSVVFTSNLHKLYYGSTGVQRLVELVVAPPLPNLQSLAIHITQTGSVIAVGITKISNQWWTQEIEMSSAIQLSETVPNSALAVQFVTEAKAILYEVIPADEVGGGALTLSLMTAGKQLNQRSGGRAIITDSLPEIQTPDYLVIVGRARVYSQFEAETWRSRPALNYDITIQPYYGKTVLMYLKLKGDVPGWHCGDVGKTLEMPGATSILILACHNRTHIQGLPLLSHMVQPTYPAKRWRLYDLRAYPNQADVINQTLSVNTSAGVACLLQEGRFEFGQHHLNMALQVAGGRAKLGQILDESCCQLVNISGSLSGELDPGEWGLYQTYSDGREGNVPHLTLTEAPCRHFLTPDPNASRYPVRQLDLSDNFTFSVTASLKGKKAKKLPLMYLRVANPKVFYIRTSEATDQYGSETLTLNVKNMLHGKGSSSVTFNLPDASLLCPRTSFTLTFQATCPSTKHLHYVYQPQLSQQELLHGNPLDAKGKPILIDIPVNYRPPSPLGISIPTSRNIYNADPSKPRPRDIYQISKDTGVYKQCLDKANRSECGCTDAMKMSSLQRNTDCRERAYRLVHPGKLSMRFQILEAEKEPIELVEPYVITVKEINGRQDYSVEDESTPSLDKMKELLTEQIGNTSRLINPATVRLILTGSGLYHFRASVIRGFSYCNLEDEVQVYVDKAPLPNPTQMIVITVISVVIGGVLFSVYLYYLHSHHQPRIRKTGSQCMDPQKQREQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z634</accession>
    <name>A0A913Z634_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046471.1">
        <property type="nucleotide sequence ID" value="XM_038190543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z634"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190543.1">
        <property type="protein sequence ID" value="XP_038046471.1"/>
        <property type="gene ID" value="LOC119720726"/>
    </dbReference>
    <dbReference type="GeneID" id="119720726"/>
    <dbReference type="OMA" id="THYFILD"/>
    <dbReference type="OrthoDB" id="10392666at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="27933" checksum="2066DCE16CE04096" modified="2023-02-22" version="1">MAVSLTSTTPEFFYGLFSVVSFLCFGTVRSAPLSTVVLSTFDPTTITEAGGLQVPCGLTSTSTSTASFTFQTDYAILSLYTNSLVEKCSKTFKEYEEERFGIALSELMEVPLPDITSLSTPDLCEADRLATHYFILDGFKKAMVAVIKDEEQHNGSRNFREDFKSMSRLLGKVLQGTRDLVCSNGLRASGESRVEEAQEFTFQTISSEIKRSLRDYTVLHRLNEYVKQLNLDIRGSLGPTGAPTAVSGCARTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6W0</accession>
    <name>A0A913Z6W0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046741.1">
        <property type="nucleotide sequence ID" value="XM_038190813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6W0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190813.1">
        <property type="protein sequence ID" value="XP_038046741.1"/>
        <property type="gene ID" value="LOC119720946"/>
    </dbReference>
    <dbReference type="GeneID" id="119720946"/>
    <dbReference type="OMA" id="LTYTRTI"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="311" mass="34169" checksum="0B6F5B411C4EA5F2" modified="2023-02-22" version="1">MAEQATQAFQAIVGIVGICGNGLVCVVIAKNRFMHTLTNAFIFNQALIDLIGSLMTLLLNLVPIPDPIPPGAAWVFLCSVWISDYLQWAPFTASTFNLITLTLERYLAIVFPFRYQALATRKKAIAVLVGVWVAGFLFSSFGIYLRYYEAGVCVIKQVAHPQVLGVCVFFVNYCLPVSIMLVVYIHITVVLKKGAGRIQPGPAAAGPSTEGQGESLMRARRNTFKTLLIVCAAFIICWTPNQIFFFLSNLGLKVDFSSPIFYITIGMVALNSCLNPFIYAIKYKQFQKGLKVVFGKRGDRASIATASTGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6W5</accession>
    <name>A0A913Z6W5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046565.1">
        <property type="nucleotide sequence ID" value="XM_038190637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6W5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190637.1">
        <property type="protein sequence ID" value="XP_038046565.1"/>
        <property type="gene ID" value="LOC119720792"/>
    </dbReference>
    <dbReference type="GeneID" id="119720792"/>
    <dbReference type="OMA" id="VIQEWKS"/>
    <dbReference type="OrthoDB" id="10255247at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="156"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="332"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="547" mass="62646" checksum="960EFE71557689D9" modified="2023-02-22" version="1">MPATGKGTSNAPITEQISEVSRKIALLDGDRKAYFESSQWTISQNRDTISKLRKENKMLHKGLAASKAGDERVINTAFKERNVERASLRGKSGKEAILQMDQKVCEAKKRLNYENAQTLKMEKKLAELETQYAQMRKDASDADAMDAGTSDEAMTLRSLENRLDKALLKLHEAEHINRTYLAIRDQMVKDSLTFGNDLDVLEAEIDTQKEEVKRLQTMNRDAQISRDVAKAELSKHEETVYREKREREEALADLRKQAEEKKAHAERVERRLHRASIQHDELTTEQKQLISGEEQEKKIGSYEEAFHAIKDATGVSDLHEVVMRFESQEETTRHLEDLKESGEKQVNRLKEDKAKLQREFEEMKYSGEARLSSGQRMLEDFQTHLKNEEDRREASQDKLDKSSKILVNVKSGVEHLADKLQHLKASKGHVPQAQLSPTSDEFVLDLLSTCEEKLLKLMEDLDGHDVDDTLQQMEDEEFHVGIEGQMPQHNTRIKLAAVARDTAYDDDDESGDDEDIITRSQLKKQAQTLVDSKTKKHKVRARKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8X5</accession>
    <name>A0A913Z8X5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048197.1">
        <property type="nucleotide sequence ID" value="XM_038192269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8X5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192269.1">
        <property type="protein sequence ID" value="XP_038048197.1"/>
        <property type="gene ID" value="LOC119722223"/>
    </dbReference>
    <dbReference type="GeneID" id="119722223"/>
    <dbReference type="OMA" id="PQREITN"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000003">
        <property type="entry name" value="Vomeronasal 2, receptor 120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF422">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="331"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="634" mass="72068" checksum="19D977A18709A33C" modified="2023-02-22" version="1">MRLDGSLTTLTFDFNACKIEYRSFHLPLPALTWISTDTWTDIAARDFRIMANVLMVTVESTEVPGFQTYLRGLNPFLEEFKDDPWLREIWEGEFGCEIGSLEDWESSRTCARHTLLENEKIAKSAVSPSIYRVYLAVYAVAQALADIERCKESQGLLADGRCPSVRRIKSWQLMKYLMAVNFTVGGIGRHVSFNRDGGIMDTFKVIQWHRCEDDEVPDPDCQIVRFVEIGIHKDGVLYMNESRSRWYDDDTNIDLPPAGVCQSPCPPGTRKVSRDGLPTCCFQCARCPEGSFTNTTGQLVCMQCPQGTWSDQNRSVCYPKTLDVLQWDEAVSVVVMCFCGLGMICTLMMLVTLTVYNDSAIVRASNREISYCLLTLLVVSFLEPFLYIGMPVAWSCNFRIALHSLNNTGVLAIFVVKTRRILDVFDTTWRGFSLRSRLRRTGLQVLIINVLMLVQGIIVTVYLIIQPSRVLLDQNISNSRVYVQCDSAILAFVAMYSYNAILACIIFVFSFRARKIPENFHETRYITVTMLFYMVIWVVSLPTYFSTTGKLQALMQIISVVLTNYLILGFMFLPKCYIIFITPERNTTQSIREQACGFRMGEINNTLVVQMDGEARRPSSRLSGSEHDIHGNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9S5</accession>
    <name>A0A913Z9S5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047761.1">
        <property type="nucleotide sequence ID" value="XM_038191833.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191833.1">
        <property type="protein sequence ID" value="XP_038047761.1"/>
        <property type="gene ID" value="LOC119721892"/>
    </dbReference>
    <dbReference type="GeneID" id="119721892"/>
    <dbReference type="OMA" id="CQNWAEC"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15441">
        <property type="entry name" value="7tmB2_CELSR_Adhesion_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000202">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1217"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1318"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1362"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1406"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1433"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="245"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="20">
        <location>
            <begin position="480"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="22">
        <location>
            <begin position="777"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="24">
        <location>
            <begin position="797"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="23">
        <location>
            <begin position="1031"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="25">
        <location>
            <begin position="1215"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1504"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1726"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1504"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1531"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1797" mass="198287" checksum="95CF5202AA91DE05" modified="2023-02-22" version="1">MVTNDLLFSSITVQLENMNSQEFLSPKINRFVDALSNIIPTQRNLIYVFSVKDHDVTDPPILNVSFAAQHQDGTFFTSQYLQERVYLMRSTLSEVSTAKVLPFGDNLCLYEICSGQDYAQCLSPLSFWSSSGFIATQTVIFRSIHPETLYKCDCPPGFTGNYCTTEINYCYSNPCGRNGQCIQKEAGYTCVCNNNFAGPNCEVDFDEGRCTDNLCKNGGLCRNFLLGGFECVCLGPEYDGPLCEIRTRNFPDNSFLMFRSLNRRVRFQMSLSFATKVDNGLLFYNGRYNQKHDFIALEIVNRQVRFLFSAGEVTSVVTASILGGVSNGEWHKVSVDYLEQTATLILDDCNAAVSLQHGEELGNYSCAASVTQGGQLKFLDMTGPFILGGLPMLPEDFPVINTDFVGCLRDVYIDSELLDLATATNLEPMGNTLPGCSHREDFCTSGPCGGDGGRCLSEWDGYKCLCPDGSGGRNCQEDLSDVMTFQGNGLLTFPPLTSVVTIPWLNRVVFRTRDFNGVLMNIELASSLTIQIELDSGQIKYRTPTVTAKLDNVEVNDGQWHDFTAEWKNNQIVLTLDFNQHTKSVTARDTIDGQTVSAVHVGGLVNSEGTLRRGFTGCVQGLKVGDNVLAIAAAEQRNIQTGCDQLDSCSFQSITCPSASKCRDLWGKYECVCDQGHYGPDCVSACDLNICQHGSSCIPSNNAPYGYYCECSDQYYGDHCQYRVEECDENWWGYKICGPCECDEERGFNSDCNKTTGQCYCEEYSYQPENSDTCYPCNCFVEGSYGPECDQQTGQCRCKRGVIGRACDACVDPYAEVSLRGCEVVYDSCPKRYAQGIWWPNTKFNQEAVVDCPQGSFGKATRKCSLDDNWLQPNLFQCMSEAFHALKEMLAELRHVKRLNPDLSFSAVEKVHQATEDTDKMYGADVNITYDILVLVLNHESKQEGLNVTAAIRSSFTRKIVEIASRLLDPDNKAHWAVIQKSSKGVSEVISSLEAFGANIARTSDYTYTPEFSIVTPNIVMHHDIIVREDFNSTVIPKYEVEQWEEGIERDTTRIHIPDDAIQPKPELEDPSMISIEGNVAVTSYIKYNTVGQLLPNQSDITIKPSEGAVGQVINSPVISLTLYDHLASEGSTNNLPTPILLEITTLGASVLDPQCIFWNFSLFDGVGGWSTKGCSVSSFNDTHVNCSCNHLTNFAVMVDNANPVKVFGQQPLALQIVSYIGLGVSIFALVFTFFTLLCIPSLHCNLNSIHVNLVFTLITAEVTFLVGINTENNIACTIVAILLHYALLSAFGWMFIEGIHLYRMMTEVRNINQGPMTYYYVIAYGLPGLIVGLAVPLSEANYGQQVNVNNQHFCWLSIEDILIWSFAGPVLAVVVMNLAVFFLAIRVTLTGKTKNPEFQNTKSGLRSAGILLPLLGITWVFGLLAVNQDMVLYQYLFAAFNCLLGFFIFLFHCILNSKVRREWMRCCLGIQGKKVQFDESVNTSRSALSYSKTDGQFRHHIGISTGSIGSSHGSRSTKASNRPEGYLRNTASTSTTSPSNHEYVPSYYNYKPKVTNLDDPDNLTLLNPQRNNLLDDQDSDSDSDASIQRNRDSMSLASSHSSDEEEEEGVDLWKTAPTKVNLPDNITSHGLGPLHSTPKEMTVLPPDNADIKRKWPGEPYTGDMETIPESTLRAELKILDPKFPLDNDRDNSVTGSVTGSVTGSIDGSNRNLIVSHVSARPDILPLKGIMKTPGSSHKGSSHGSGSGSGSNASLTKIPMSVTTTPDKYGSGLGVSFPPEQRSHDSESDGSSNETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAI0</accession>
    <name>A0A913ZAI0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038048772.1">
        <property type="nucleotide sequence ID" value="XM_038192844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048773.1">
        <property type="nucleotide sequence ID" value="XM_038192845.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048774.1">
        <property type="nucleotide sequence ID" value="XM_038192846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAI0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192844.1">
        <property type="protein sequence ID" value="XP_038048772.1"/>
        <property type="gene ID" value="LOC119722634"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192845.1">
        <property type="protein sequence ID" value="XP_038048773.1"/>
        <property type="gene ID" value="LOC119722634"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192846.1">
        <property type="protein sequence ID" value="XP_038048774.1"/>
        <property type="gene ID" value="LOC119722634"/>
    </dbReference>
    <dbReference type="GeneID" id="119722634"/>
    <dbReference type="OMA" id="MIINWYL"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="268" mass="31531" checksum="E2EEE0BCBBDEDB09" modified="2023-02-22" version="1">MDFISGLGAKVAYVYELLEAQGDPRVENWLLMKSPIPISCIVIGYLLVVWLGPKLMANRNALQLKPILVLYNFFLVGLSIYMFYEFRVTSWKANYSYRCQPVDYSNSVLGMRMARVCWWYFFSKVIEVMDTIFFILRKKNNQLTFLHVYHHSSMMVNWYLGVKLIAGGQSFFLAMLNSFVHIIMYSYYGLAALGPGMQKYLWWKRYMTQIQLMQFLAVIIHTGYNIWVDCDFPQGFNYAVFLYSISLVALFGNFYLKAYTTKQEKYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBK1</accession>
    <name>A0A913ZBK1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048265.1">
        <property type="nucleotide sequence ID" value="XM_038192337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192337.1">
        <property type="protein sequence ID" value="XP_038048265.1"/>
        <property type="gene ID" value="LOC119722294"/>
    </dbReference>
    <dbReference type="GeneID" id="119722294"/>
    <dbReference type="OMA" id="IPVHPGM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="437" mass="47941" checksum="C37170B686B9FD4D" modified="2023-02-22" version="1">MGNKIEHPSVELPPEKLVMVTGGNTGIGYETAKSIAEMGARVCITCRSEDKAKAAIERMQEEHKNQMQKRSHAENAAAQASSQPTSEEIKPLNVEYIKVDLASLQSTMDFIQETKERMQYLNVLVCNAGIGFAKQAYTEDNYESHFQVNYLSHLLIVLHLMPLLQTGAPDSRIVLLSSAAHKGGKLDLDNMQGRKSYSRIGAYGSSKAYMIMAAHFLSRRLEETGVSTFSVDPGIVDTDIVNNYSDWKLLSFFGGASKKMGMMRTPKKGAATSVVACVDPSLRGKTAVFMKSCRPANPANFCRDGKKQEDLWGYSLGCLNQFISDDVLKEAFPSARPELLTIPKDTRTVEEKIADDSGKKEGSSGDKEMGDKSKGGEASLERKQDEEQPEIESSSGATEVPSEKVKASQEPYGANLEEKIPEDTLKDEDNEPKASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD52</accession>
    <name>A0A913ZD52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049708.1">
        <property type="nucleotide sequence ID" value="XM_038193780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD52"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193780.1">
        <property type="protein sequence ID" value="XP_038049708.1"/>
        <property type="gene ID" value="LOC119723217"/>
    </dbReference>
    <dbReference type="GeneID" id="119723217"/>
    <dbReference type="OMA" id="PREGHNA"/>
    <dbReference type="OrthoDB" id="6082926at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42055" checksum="172B1FC45DED4B1C" modified="2023-02-22" version="1">MENIFASNVTPEYGWDAERPNAVNVDTILLIAHVLVFLLGAPGNCLILRVYWTKTRKTSTDILIRALAWADLAVCLLSIPEIIVISLFLCGHLFAYSLFQELIYAVIPLTDAAIVSSFSITAVIAVERYDCVCRPQKRIFNPRRSKMAVLVVVLFAIAINAGQMALNICLVVSGTEPPSLQVYRKIVEIVQLVSFVTALVTMGACYGKVYVTIRKHVKVGPAQAPTARDAERIPSDLRVGRQVNCSTRLTPPQQNMDLPTSESFVDEAVTRFVHPPSTSSSMHANSHQAKPNDVCTAAHVVSFAHQDSSGPSQPNVIPEPKAAPQDNTPSQRQSRPEPGHAPQRVGAAKLQRKTTRMLFITSVVFLVTWIPSLVTVVKSYASCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDL5</accession>
    <name>A0A913ZDL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049867.1">
        <property type="nucleotide sequence ID" value="XM_038193939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049868.1">
        <property type="nucleotide sequence ID" value="XM_038193940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193939.1">
        <property type="protein sequence ID" value="XP_038049867.1"/>
        <property type="gene ID" value="LOC119723350"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193940.1">
        <property type="protein sequence ID" value="XP_038049868.1"/>
        <property type="gene ID" value="LOC119723350"/>
    </dbReference>
    <dbReference type="GeneID" id="119723350"/>
    <dbReference type="OMA" id="RHEKEHA"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001840">
        <property type="entry name" value="Paternally-expressed gene 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="35502" checksum="72B000D68B723FD8" modified="2023-02-22" version="1">MDGLVIEEEFVASEEDEITHPVPSAVTKLQGDDEMSAKKFICDVCGKGLSTKSSLKVHNRIHTGERPFACTFCSKSFQTSNGLAVHKRIHTGERPYHCSQCPMSFKISNQLKRHRVTHIQRPLIRCQRCGKDVDFKKPKDQRAQDLCEGGKQHQRPPRISHACGKCSKTFSGVSALTRHWQRTHSKKSFQCVTCGRAYNQNSALMIHQRIHTGEQFVCEVCGKRFQQNSHLTVHRRAHSGELPFQCKYCPRGFKQSSHLKDHQRLHTGERPFVCQCGKSFRQSGQHRDHQRFYCSFKKILEVSDLSPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDX6</accession>
    <name>A0A913ZDX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049689.1">
        <property type="nucleotide sequence ID" value="XM_038193761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193761.1">
        <property type="protein sequence ID" value="XP_038049689.1"/>
        <property type="gene ID" value="LOC119723201"/>
    </dbReference>
    <dbReference type="GeneID" id="119723201"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="120"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="51570" checksum="6FE3288E13A5AF49" modified="2023-02-22" version="1">MWWYYANVTVYAQAATSLAQLDILVCTFFTCVFQNHSDNCSLAYSAPQMDHLLIWDETGPSPWAAMNESFDAPSNERYKLLNHSLLILAFKNPAEADQFVFSSTQTVLYGFVLPVLKLLGILSILSFFFTLCRVASMRNITNFYLTNLAVADLMVLISESTYQQCVALTTQSELDASYLGNSAQAVFILLTYTCDVGVISSIAFVTMLSYGRYFAICYPFQHRNLNLKRRAIRAAVCIWFLSFSVNLIVFFNQFLGFNVPPMKCLVWPTEEKYKHLSGNGHMFFNDDETLNLVVSYMFFCVFMLSLILTVTFNILLIKGLHAPNPTDDQIRGPSKHLRKVTLILGINTAVVFVCSLPQAIYALIAILVRSREEVNVNDDVKWKLDVLIACLRVLNSSINSVIFNAGSGRYRKAFKQAFCCRKRQQVPTNNIPLQTLPRADPADRIRLQDPKAKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGD6</accession>
    <name>A0A913ZGD6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-beta-hydroxybutyrate dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050487.1">
        <property type="nucleotide sequence ID" value="XM_038194559.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050489.1">
        <property type="nucleotide sequence ID" value="XM_038194561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGD6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194559.1">
        <property type="protein sequence ID" value="XP_038050487.1"/>
        <property type="gene ID" value="LOC119723739"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194561.1">
        <property type="protein sequence ID" value="XP_038050489.1"/>
        <property type="gene ID" value="LOC119723739"/>
    </dbReference>
    <dbReference type="GeneID" id="119723739"/>
    <dbReference type="OMA" id="DERGCNV"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40718" checksum="F5A8FA2BC295D7E8" modified="2023-02-22" version="1">MPVDRQTYFYSWAILSLLALAVYLGEDSIAAKIIAGTLAVAGLYIGGKLVPRGHVSPEGKAVFITGCDTGFGNGLARRLDGCGFTVFAGCYIPDGPDAQQLAKETSSRLTIVPLDVTSDESVEDARDMVKAGLQRQRAELWAVVNNAGIWRWGLIEWTTIKQYKQVAEVNVYGMIRVTQAFLPLIRRAKGRIVNVSSVSGLWTIPYISSYFMTKYAVESFSDALRFEMNPWGVKVVLVEPGEYGKLTGIALHSRESTLAVSEPLWDGMRDDLRRDYGREYFDGHVQRLHQAREACWDDLTPVLDAMLDAVASGRPKHRYLIGELSTYYLKFKFSLLPSWMTDWTLYKLDEPFPKPAALREKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHG1</accession>
    <name>A0A913ZHG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051223.1">
        <property type="nucleotide sequence ID" value="XM_038195295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195295.1">
        <property type="protein sequence ID" value="XP_038051223.1"/>
        <property type="gene ID" value="LOC119724306"/>
    </dbReference>
    <dbReference type="GeneID" id="119724306"/>
    <dbReference type="OMA" id="VATCEYD"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="7">
        <location>
            <begin position="145"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="7">
        <location>
            <begin position="355"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="51105" checksum="782352C624D36A8B" modified="2023-02-22" version="1">MLDHRKDTNKSTKRKMTPRGRGMLLKRSPIRAPYVSYCVVLVVTMTMLLTAFYVNSPTPNGIKNPWKYRCFLAGKRVVADMAKVLSLLTSTSYVNNFRFLMDIFVRPTPLEMPGSNIRASVTTFGGVKVRLYQPIRREPGRGPALVYAHGGAFAIGSAASFDPVTRRIAEALNCTVVSVDYRLAPEHPFPAAFEDILNASKWFMDHAHDFGVDRSRIGIAGDSAGGTLAAVVSQELHDDPAYPDFAFQAPIYPLTQLIDSLTPGTLHSKHHFGRDGSIVTWDEAAMFCSLYLTGGEHARLQLALIRNVHVAMEFRRSDAPQLKYVNHSLLPPRLRSYDFLTPSSSHVNHGHLSEAEGVWKEIKDKVLDPRVCPLMRHNMGGLPPTFVATCEYDAVRDHGIFYAMRLREAGVRVRWEHYDGGFHGVLGPSWPFEFEVGEQMFHDFGDFATEHLKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI20</accession>
    <name>A0A913ZI20_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 60</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051433.1">
        <property type="nucleotide sequence ID" value="XM_038195505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI20"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195505.1">
        <property type="protein sequence ID" value="XP_038051433.1"/>
        <property type="gene ID" value="LOC119724444"/>
    </dbReference>
    <dbReference type="GeneID" id="119724444"/>
    <dbReference type="OMA" id="RDIIHCK"/>
    <dbReference type="OrthoDB" id="10017343at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031526">
        <property type="entry name" value="DUF4698"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34754:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15769">
        <property type="entry name" value="DUF4698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="89009" checksum="6CBC3D93B2B0EB4E" modified="2023-02-22" version="1">MSPAKTRDPRSYIQATPLTLPSHQGEYILARSDTQYRSNCAAPSKEEIFKENYARRLQQMKEQGYQSVNHKPYKLLGEPLHLKEKKLILHALGQETAQSEDSSGSCSDEEGDEDKEKKEGALMQQQAENKPPQRKFVFRRNHKNKKSLNKEISSARKMVNWVKLGHGVFTTIRKEDEDRLNAEEIKKLQDAERRRREWQPPNEDSSDEDTDDELARDEDISIFLTSSSSDGKKEVSFSRSETHLYTPASRTPSPPRPHEPPSPPRPPDPPSDPTPSTLIGDQSGATTPAKSILSSSSSPVVRRRRKKKNTEPPRPYTPIRSNINVDSEDEGRANRDAIFRQLCVLNWILEAMMTEPPAAMEPITKCWNIRYKDLRQNTFCKTTMRDKRREKLVDTRWHSFVSNPGAGHLKSRVNTNKTSLYGPNLTTSMSYVRQPRRGSSTMALGQAKAASAISQSANQSSADSTPRRDEDGTGKRENLRELGKTTSTWKMLDDINESASMVGKNEDNDDAASRRGPRQDRSPSIVSERSGSATSSSQRTVTKGPTLSQKHLEERDQKVGKPRERQIHTWVATTNRKLRTMSAPPKSEFKPIFPSRKHAHLPSELRSRFADVTEDKALILHDKLEVLEKKKLWRSEEKFRAIQTNLHISAQLERMKDAARDNEESAEEKMRKKRVEEESKWFQELTSRLPSYVFSDMACAALLDKLQGMGIIESRKITPQKFLNVLTGLKPWELCLPEVSAAVEFVRERVVLMSVEEFEAWYQHEIPGISRSQSAPPNTFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJU0</accession>
    <name>A0A913ZJU0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051609.1">
        <property type="nucleotide sequence ID" value="XM_038195681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195681.1">
        <property type="protein sequence ID" value="XP_038051609.1"/>
        <property type="gene ID" value="LOC119724572"/>
    </dbReference>
    <dbReference type="GeneID" id="119724572"/>
    <dbReference type="OMA" id="DICKCAH"/>
    <dbReference type="OrthoDB" id="664115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="243"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="420"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="463"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="506"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="4">
        <location>
            <begin position="550"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="876" mass="99254" checksum="50E7375748AC6AAE" modified="2023-02-22" version="1">MILTSGLEDLMDIHVYSRQRQRVSSPCLLNNGGCSDICLMSPNPRGYSCACTVGIRLMEDGQTCELEMNEFLLIARRTDIRKMSLDVPYYANVQIQPDDIRKAIAVDVDVVEGKVYWGDITEKTIGRSDLDGQHSEVIIKDNLQVMDGLRIDSIGRKMYWTDTGKQRMEVADLDGGNRRVLIWTEIDKPRALALDHEDGYMYWTDWGVQPRISRAWMDGQNVEVIVNTDISWPNGLALDSDEGRLYWCDGNIDYRLIASVNLDGSHRRTLVNQDIYHPYGLTQAGDYIFWTDWQLNSIKRADKRTGDNVISVTENLPDLMDIKAVDMNKRGINRCGDDNGGCSHLCLPNPLGYSCACPTGIQLQDNHMTCDDVPSTFLLFATRNTLRRISMDTDDHLDVILPIQEDIENAVTLDFDSVECKIYYTDVYLNVIRRVNYDGSEGETIISTSLGTTEGLAVDWIGRNLYWTDTGRDKIEVSRLDGSSRKVIVDTNLDEPRAIVIYPRKGYIFWTDWGTYPKIERAYFDGTSRRTLISEDLKWPNGLTIDYETKRLYWADANLDKLETADFNGKYRSILTRNMSHPYGVTLFNTRLYWTDWHTSSIESVDKTNGRDKRTLPGSFQGMNIQMVSPLRQTGTNPCAIANGGCTHLCLARPQGYVCACPDEQYRDHRVCSLRPGGPDSPPPVTIRGPIIQTNSPNELPRSTRGTTKPPPFRTEHPNVIPPAPTTEQGNVIPRGCSPENEQLGLCQGSTWQQGKDDKRQLAPEPGSYVFVIVGILLLIFLILLLVVFVVWRRYQKRRGCRSDPIVTFSNPRFNPITNEVTILPKRQPCSWNYYSEPRSKIPQANLVVKLNNEEVAKMLPPPPSSELPLKKTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJV8</accession>
    <name>A0A913ZJV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052073.1">
        <property type="nucleotide sequence ID" value="XM_038196145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196145.1">
        <property type="protein sequence ID" value="XP_038052073.1"/>
        <property type="gene ID" value="LOC119724864"/>
    </dbReference>
    <dbReference type="GeneID" id="119724864"/>
    <dbReference type="OMA" id="ADEHRIM"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037803380" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="38623" checksum="193D7645CEA45B2B" modified="2023-02-22" version="1">MGKSLLCCFLIGQLLLCCHGDRYQGGSHHPIGHLPALSGEMIRYVNNLNTTWKAGFNFPGKNASFVKLLLGGKLTTSVPDDHRLPLKPRSDVDAKDIPENFDSMTKWPECDSMKKIYDQGACGAGWAFGALEAMSDRYCVFSNMKKVNVTLSEENLISCCGTHCGFGCEGGYPSAAWQYWVNTGIVTDGCQPYTFDPCRHVGGSDEGSDGGAPEPTCAPETQTPKCHTECGKGYNKSYTDDLHFGKSSYAIEGSVTQIQEELINFGPVETSLNVFEDFFSYKSGVYQHVAGGFVNRQSVKMYGWGVTPDGVKYWLASNSWNDSWGEKGFFKILRGTNECGIEEDIFAGIPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK86</accession>
    <name>A0A913ZK86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin NUP42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleoporin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051500.1">
        <property type="nucleotide sequence ID" value="XM_038195572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195572.1">
        <property type="protein sequence ID" value="XP_038051500.1"/>
        <property type="gene ID" value="LOC119724493"/>
    </dbReference>
    <dbReference type="GeneID" id="119724493"/>
    <dbReference type="CTD" id="11097"/>
    <dbReference type="OMA" id="CHNEHFD"/>
    <dbReference type="OrthoDB" id="10066058at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="464" mass="47337" checksum="3EE1397320C56214" modified="2023-02-22" version="1">MVVCKYYMKGDCKFGNQCRFEHPRGGSGGGGYSGYGGGGYQSYGGGGSYGSRGSGNYGNNGQQQSNYKNPYVYHKDTSGGRNYDGRGQGGGGGGGGGGTKKVVFRDSFGSFGGNQNQFGALSNLSDQTPNDDIKEQDILDAIKHDIDEWEGSKIWPLSSYRPNKSRCGCVPGFEDISPDEVRFLAYTAEKENKFDQHKASFASVLGIYKRQRDMLRKPSTDMKAQLINVFRGGQTSGSIFGNTESTVQILYSTLPGGSSQALGASTFGSTSTGFGSKSSSNSSGFGGGTFGNTQPGNLGGTFGTQGQSGGGASAGLFGKPASTGATGTGLFGKPASTGTTGTGLFGKPASDGTTGTGLFGKPVAVGINDSGGSSGMFGSGGSTGQTGLFGKPAAFGSSQSSSFGMTQGDFGSSSSGGAGASSRSQGSTYTPLSELTPEEKEQFEATSFTLGKVPSRPPPMELCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKC9</accession>
    <name>A0A913ZKC9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051496.1">
        <property type="nucleotide sequence ID" value="XM_038195568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195568.1">
        <property type="protein sequence ID" value="XP_038051496.1"/>
        <property type="gene ID" value="LOC119724489"/>
    </dbReference>
    <dbReference type="GeneID" id="119724489"/>
    <dbReference type="OMA" id="HECSAVC"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF393">
        <property type="entry name" value="PROTEIN SLIT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218325" evidence="7">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="445" mass="50682" checksum="1A565506C2AD8BDD" modified="2023-02-22" version="1">MHTNMWYIWTLLICSPSIVYSQTMQPPHECSAVCEYTHWALDADCKNRNLTSIPGQCSQVVTFDLRHNHIRILPVGAFEEFVNLRYLDIEMMELETITPGAFQDNINLVHIYIQINQLTVIRSFTFKGVPNLKQLFLNSNKIKVLDPGAFEGIPKLETLFLSDNDISEISSDLFRNLTKLRYLYLENNHISDIPEGTFTGLTNLRHLSLAGNDLVHIPSGLFDDLKHLRALKLSYNHIISINPLPDLPRLNHIDLFNNQLTSVSNLTDFLKAPRRRRRSNGTKKFTELFLAKNPLNCDCDIEPLRIWLQVHREEIRNHHRANATCASPAELSDVSLCNQQTPFCTLHTSTQLSTDHPDTKALTRAASPLIHISDEAESTLMPITIVVVSISSVVLVTLLILTVYMKCRNGRIPYQKHNTKGSDDDYKQANITENPMNKHAKYSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL18</accession>
    <name>A0A913ZL18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051741.1">
        <property type="nucleotide sequence ID" value="XM_038195813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195813.1">
        <property type="protein sequence ID" value="XP_038051741.1"/>
        <property type="gene ID" value="LOC119724660"/>
    </dbReference>
    <dbReference type="GeneID" id="119724660"/>
    <dbReference type="OMA" id="ALCWLDA"/>
    <dbReference type="OrthoDB" id="6160353at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028890">
        <property type="entry name" value="Peptidase_C98"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033505">
        <property type="entry name" value="USPL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15294">
        <property type="entry name" value="RETINOVIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15294:SF3">
        <property type="entry name" value="SUMO-SPECIFIC ISOPEPTIDASE USPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15499">
        <property type="entry name" value="Peptidase_C98"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="138"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1152" mass="125418" checksum="47AC25B6A8D5B979" modified="2023-02-22" version="1">MEADVRWCPHCRQSGEKKRLRLLQINDSLAVLLCENEKCVGLGETSSTSTVIHQRKASDIPNTRKKKNKLLPACNAAPKIPDSSPPNGSIQSSDAGNAESLSEKQACGTPIDSKCAINNASPALRAGSFSSTAMPQVALWANKSALCWLDACLCLLVACRSLHTCVAKLPAKSSVRTLCTAFVEAQRPRTTKKSETQDSCCDESQLSEASVLPPVRLTCTGDTSTNAVHSNTDITRTAQSEQDSLHSTRNAEFCQTKGESDPLDKARDEIYRRLQPMMKCESGEEDSPVVALASLLRLDGSVEEHFMCQYRWEFCCSVCGFTQVNRTKKTMPTFTSVPADFSMKDPVMLHSCHKCGAQQQRSRLVFHSLSACVMMHFQGGLPDSDLSKHHTFIFSGDAYTLAAVVRYRGNPNHFVTLVRDQETNHWLEYDDLMPSPFTWQPEPPSIPAHEIHIMVWERSEKPCTACAEMHLNVTGILDAPVHTPASGVPVGDADAAPQQHRSAQWNGNGSWRKSKFSLSNSFWRKSVQERDATNRSDSGRHSSGPAKVGQETSDAIDVDKETNGSGVEIDLTAEMESAPTVDEGLEESKSDSFGNLDPQSLSKVDTKETPKVPRSNQNATKKPQRNARTEHLQDGKSVISLKTNAARKPELNTDAPQPTFLRSLLCRRKSNKDKDQTTTTAAILAKIPDQLMKFSRHSNVSSRPRIGSAPSNQESTSRNASVLSKIPKQLLSGSANPRAAPSQQSQSELSRPAARPKLVGSSRRVPVKQVKFQPYEQNLELKIQQENKKNLPVKQGIRSNASTLNSWQKRVGKYSSSVDVPRKRVRRDSSEDSSSTYSDLPKHAGPPCSSVSSPSACSDISSLSDNQLFASGRNDLTNTIDELCKVLDIGGDYTPPVSSRLSSPSQDMFFSELFTNEPVSERLDPISHANSTGLQMPLASFDNHAPVTMATEMSATSSTSHTHLHSSIHEHCPSSVTAPSVESFRPAATALSTSTPMGSNKLQTDLAAANISSPNPLEGTLPSVGTERLALAPVGCPAQSQSAMLPSCDSMQSTIDPVAMQQDSDRPMQHVDNSPVSHVASHGDHMTAASGFSSLTDTESERNIMAFSSSTHCEAAQAMDDIIDTGLFEDIQESLDMLGSEWNENLIELLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZML5</accession>
    <name>A0A913ZML5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053048.1">
        <property type="nucleotide sequence ID" value="XM_038197120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053056.1">
        <property type="nucleotide sequence ID" value="XM_038197128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZML5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197120.1">
        <property type="protein sequence ID" value="XP_038053048.1"/>
        <property type="gene ID" value="LOC119725637"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197128.1">
        <property type="protein sequence ID" value="XP_038053056.1"/>
        <property type="gene ID" value="LOC119725637"/>
    </dbReference>
    <dbReference type="GeneID" id="119725637"/>
    <dbReference type="OMA" id="QNRLALW"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="33242" checksum="6B771B03F7A20E95" modified="2023-02-22" version="1">MSETLGMETQPVQVEGATDDANGQNNSNYGATSLGDEQRSRVEVTEKRTMCTPWLFVGLGWLPISVGLSLALAIIVPYCIAVGLGHVSAGFPYISDTGTEPPESCIFGQLLNIASALAFATIYVRYKQVAEYYREVPEGVFKCNKAALVLGSLAALGMSLVANFQETNMIVFHVIGAMMCFGLGFIYGLLMSWISYKLSPQHCTVAMYRARLALSLVAMLCLVTTLLFGGLANSQWKGEDLRKWLPEDGGFGLHVASTVSEWIMAIAFLFYFFSYIKDFQKVELAAEVRRCQRLLNVTCDPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMY4</accession>
    <name>A0A913ZMY4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053158.1">
        <property type="nucleotide sequence ID" value="XM_038197230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197230.1">
        <property type="protein sequence ID" value="XP_038053158.1"/>
        <property type="gene ID" value="LOC119725701"/>
    </dbReference>
    <dbReference type="GeneID" id="119725701"/>
    <dbReference type="OMA" id="LESKMLC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01371">
        <property type="entry name" value="KISc_KIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000017">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="710"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="497"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="754" mass="85397" checksum="561DAC78519D3BFA" modified="2023-02-22" version="1">MSKKSESVKVVVRCRPMNSKETAEKYERVVDMDVPRGVISVRNPKSSLEPPKQFTFDSVYDWDSKQRELYDETFRSLVESVLNGFNGTIFAYGQTGTGKTYTMEGVRSDPESRGVIPNSFEHIFTHIARTQNQQYLVRASYLEIYQEDIRDLLSKDQSKKLELKERPDTGVYVKDLSSFVTKSVKEIEHVMTVGNTNRSVGSTNMNEHSSRSHAIFIITIECSELGPDGENHIRVGKLNLVDLAGSERQAKTGAKGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANLGPASYNFDETLTTLRYANRAKNIKNKPKINEDPKDALLREFQDEIMRLKQQLEKKGGGGGGGAKKRKRRRNKGEVGGSDDEIDDETEEGEEMDEEEMYKQAQEKLEAEKEAIMANKSMIAEEKEKFLHELQDRQGLLKKQQEARDALESKIKAMESKLLVGGKSIIDHTDEQQKQLEHRRLELAEKTRIEREMQQKLEEKEENTEEMAKTFTSLQQEVDIKTKKLKKLFAKLQATKCDIQDLQEEHARERQELEQTQNELTRELKLKMLIIENFIPHEEKNKILNRSEFDEDTDQWVLKPLARSEGPTQMAKRPVSAVGNRRPIADFARMAAQVGGNPRYKAENILQVELDMPNRTTRDYEGPSVAPRVQAALDAALQDEDDLDLEVQPSVFAGRAKTKLKKEKTKTRSKPAVTSSNASALRKTGGNSQMYPSARGLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP04</accession>
    <name>A0A913ZP04_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052776.1">
        <property type="nucleotide sequence ID" value="XM_038196848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196848.1">
        <property type="protein sequence ID" value="XP_038052776.1"/>
        <property type="gene ID" value="LOC119725441"/>
    </dbReference>
    <dbReference type="GeneID" id="119725441"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="500" mass="54017" checksum="A127BBEA60F8DA84" modified="2023-02-22" version="1">MRASPKNHVYQEGGWGWIVVFAACLSEFVVAGSLKAFGVLITGMKDDFDTGLWIIGSINSLHLGVQFILTPVASVVARKVGGRPVISFGGFLFGLGVVLSALTHNIAFLAVTIIAIAGSGAGCILEIVRAEFALYFHEKYDLAIFVSLLGAPIGFLLYGPATQILLDTYGWRGAMVILGGFGFHLICAGMLVRRPTGIYKAIPIQDLSTEDQTTDQNEYQTWEQSEDQMSKHCEHQISKQGEDQILKQSQDQISNHSEDQLSKKSEDQTSEQSEDQLSKRSAQGPDPVKWRDSVVSALGLEIFINFDFVLLAAIRMFYSISFGGILVYMVPNGLSAGLTNGQASFLSTAFGLGSMAGPALAFFVLKRKLASCQVTAIIAAAVSAVGLALDPFIPSFAGQMVNTFFVAAGIAAVIQVVCVLTRYLPFTVDKFVIVLGWLGFLGGLATSVGDTLAGLLYDVTESFYGTFFLYSAAMVATGLLFLLDLCRARYREWSKESRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSF5</accession>
    <name>A0A913ZSF5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054334.1">
        <property type="nucleotide sequence ID" value="XM_038198406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198406.1">
        <property type="protein sequence ID" value="XP_038054334.1"/>
        <property type="gene ID" value="LOC119726645"/>
    </dbReference>
    <dbReference type="GeneID" id="119726645"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="151" mass="16991" checksum="22C8190802002783" modified="2023-02-22" version="1">MSGLPRRITKETQRLMAEPVPGIEAIPDESNARYFHVKVAGPAESPYQGGSFKLELFLPEEYPMSAPKVRFMTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAELWKENEAKAIETAKEWTRVYATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT28</accession>
    <name>A0A913ZT28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase TRIM37</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054767.1">
        <property type="nucleotide sequence ID" value="XM_038198839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198839.1">
        <property type="protein sequence ID" value="XP_038054767.1"/>
        <property type="gene ID" value="LOC119726984"/>
    </dbReference>
    <dbReference type="GeneID" id="119726984"/>
    <dbReference type="CTD" id="4591"/>
    <dbReference type="OMA" id="NIHTEDA"/>
    <dbReference type="OrthoDB" id="192247at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19779">
        <property type="entry name" value="Bbox2_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03773">
        <property type="entry name" value="MATH_TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16619">
        <property type="entry name" value="mRING-HC-C4C4_TRIM37_C-VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037299">
        <property type="entry name" value="TRIM37_MATH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053003">
        <property type="entry name" value="TRIM_RBCC_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36754:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="278"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="107557" checksum="DB8C6389806DD647" modified="2023-02-22" version="1">MEEATVESLAEVFRCFICMEKLRDARLCPHCSKLCCFLCIRRWLTEQRNQCPHCRAPLQLHDLVNCRWAEEVTNQLDTLQLCTPHTRPDEQDRDKCEAHHEKLSVYCWTCHKCICHQCALWGGAQHTGHTFKPLDEVYDQHVSQISEEVAALRRRLMELISLVQEVERNVESVRNAKDERVREIRNAVEMMIARLESQLKMKLLTLMGQKNSLTHETELLESLLQEVEHQLRSCTKSELIAKSAELLQMFTQVHRKPMASFVTAPVPADFMSELVPTYDSSRFVLNGFTALQHKADPVYSPPLTTSGLNWRLKVYPDGNGVVRGNYLSVFLELSAGLPETSKYEYRVEMIHQATHDNSKNIVREFASDFEVGECWGYNRFFRLDLLATEGYLKDNTLILQFQVRAPTFYQKCRDQQWHINHLEAAQRLYVTQVNDLKERLAIELSRHQSDSGKSPDHDRRNSHSEQSRSRFRSVRATVAIATDKESPNRKNEKTVSEHDEDAQLSECEISICGSSSTSLDDGANSDAENSLEENDIDEETMSLENDVDHSRLIDSRTQVECLVGQGAQGGSDASISLGHLEGQQGEEILQTLRNEEAMLLQLLDLKDRPIGAGDSLWGFLPRPPYKIRHTNAPRKSKEKKEKHHHSTPSTHESLMKKMQSCMSDISLRSHCATTSVVPILDGAECSEQASGLGSSTKIDAAQSILRKPSCSSKHSQHAVPSISLQLAQECDASGKAQEDDTGECGASTKNVDKHCNEGNLEGYYVPLSDREGTAAEALPVLSSAARLNAGIDALGVQLRASPESEVSDSDFKSTENQQVPKLPVSCLSAGEIVNIADGKDTIESLMHKDDQQRTLRTTRKKMCLGRLNTTGEDWQWGWTGVYRTETGVLENGFAPSRTHCSAVCTMVSHLCPHTANGSLCVISLCTDDVTVCLHVCFPMEPVGAHGPLSTIGTHVNKVGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTC1</accession>
    <name>A0A913ZTC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054852.1">
        <property type="nucleotide sequence ID" value="XM_038198924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198924.1">
        <property type="protein sequence ID" value="XP_038054852.1"/>
        <property type="gene ID" value="LOC119727034"/>
    </dbReference>
    <dbReference type="GeneID" id="119727034"/>
    <dbReference type="OMA" id="HIINGHQ"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="117" mass="13025" checksum="22A5522ADFF57C76" modified="2023-02-22" version="1">MDAGNTQNANVHGTEIANDPGKMFIGGLSWQTETDSLRDYFRKYGDIKECVIMRDPSSKKSRGFGFVTFGDPKCVEKVLKTDRHEVDSKKIDPKVAFPKRSPPKIGDNSEPCVETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVA5</accession>
    <name>A0A913ZVA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055419.1">
        <property type="nucleotide sequence ID" value="XM_038199491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199491.1">
        <property type="protein sequence ID" value="XP_038055419.1"/>
        <property type="gene ID" value="LOC119727564"/>
    </dbReference>
    <dbReference type="GeneID" id="119727564"/>
    <dbReference type="CTD" id="5412"/>
    <dbReference type="OMA" id="WPDEWYE"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17048">
        <property type="entry name" value="Ubl_UBL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047977">
        <property type="entry name" value="UBL3_Ubl_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="120" mass="13476" checksum="D8FC6FEDE1A57199" modified="2023-02-22" version="1">MSSNSTKKNDKIILRLIHPMNGNSKEFTFTPNDSASDVAQFVFENWPQEWESDRVSSASILRLIYQGRFIHGNVTLGALQLPAGKITVMHLMARETLPEPNSQGQRNRGKTEESNCCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW96</accession>
    <name>A0A913ZW96_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055794.1">
        <property type="nucleotide sequence ID" value="XM_038199866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW96"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199866.1">
        <property type="protein sequence ID" value="XP_038055794.1"/>
        <property type="gene ID" value="LOC119727800"/>
    </dbReference>
    <dbReference type="GeneID" id="119727800"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF85">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="292" mass="32556" checksum="B6CF1F26F8226AC7" modified="2023-02-22" version="1">MTTVAVLLISDKGRDDRGAADLVDLEIDIDENVVEEGVSGLEFNKEASVRKHCFYEICEMDIFEHRQVHQPEDPDIRISSLGSSTIFTSSATRNRQGAAVGGVAITVQTSLLPLLTSISKINDRIMLAIFKGNPKTYVVSCYSPTNTSDEASITGFYEFLNDTIASIPLHALLVIGGDFNAHVARQFSYHSTTNRNGQLLSDFVNCNNLLITNTLFQKSSKKLWTHRSPNKYLSQIDFILCRKRWRNSILDSLAYSTSDPTGSDHRIVCAKIRLSLRSCYGVALRGHRIHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWY7</accession>
    <name>A0A913ZWY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056034.1">
        <property type="nucleotide sequence ID" value="XM_038200106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200106.1">
        <property type="protein sequence ID" value="XP_038056034.1"/>
        <property type="gene ID" value="LOC119728025"/>
    </dbReference>
    <dbReference type="GeneID" id="119728025"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="415" mass="46727" checksum="344F04A95C73D307" modified="2023-02-22" version="1">MCTIHTDQKWCFYCDTCDTLICSMCATLDHRSAENNLLKIDDTIRSFRSEVDNILQKFEKCRQRFKSTENSIEHAQKRLQNKLAQARSDIDAKAKAEITKIRNKAKLLTDKVDKIGQERDNEYEKALMHNRDQMERADQTIAAVNDLMRQADDFEHLELKPKVMHNLEFQKELKFEPVNHGPSFIGVRFQDVVSDAELGEVCVSEKWQLKGEFGKEVAQGDASNQLEAPFGVAVTHDDLLFVTDKKKVKVFDTELHFVRKFTPSADDADGRSESYLTAVAVDSQRVAVADKGRKVISVHNLDGSLIASISNNMVEHFLTISSLGCLVLTNLQGQSLLCVNFEGKEMYNVKTLVNGEAAKPTGVLCDDDETIYVAVHYGRSRVDEVQRYDSNGAFVATVAQGLYNPIEMAFTPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY66</accession>
    <name>A0A913ZY66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056001.1">
        <property type="nucleotide sequence ID" value="XM_038200073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200073.1">
        <property type="protein sequence ID" value="XP_038056001.1"/>
        <property type="gene ID" value="LOC119727993"/>
    </dbReference>
    <dbReference type="GeneID" id="119727993"/>
    <dbReference type="OMA" id="EVREWIF"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="208"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="779" mass="87512" checksum="A326D478B8216A11" modified="2023-02-22" version="1">MAKTIKKQKRKDKISTSGSSSNPDRLKGAGGHNMRDRATIKRLKMYKGGKPTRNAAGKIIKPAIFQSRLPSGSVARVDPNRRWFGNTRVITQSALQTFQDEMGKVLKDPYRVVMRQTKLPITLLQEKAKNARVHLLDTESFESTFGPKKQRKRPNLKVSDMEGLLKTVEDSTDKYDEEKDKDLVTEDEGIRPEVREWIFGAGQSKRIWNELYKVIDSSDILVQVLDARDPMGTRSKFVETYLKKEKPHKHLVFAMNKVDLVPTWVTKRWVAILSAEYPTLAFHASVKNPFGKGALIQLLRQFGKLHIDKKQISVGFIGYPNVGKSSVINTLRAKKVCKVAPVPGETKVWQYITLMKRIFLIDCPGVVYPTGDTDAEIVLKGVVRVERCESPEDYIPVLLDRVKLDYIRKTYRLTDWTDPTDFLEKVAQRTGKLLKGAEPDIRTVAKMVLNDWQRGKIPFFVKPPNCEVDPEVEKKEVIDKAKVQDADDAYKTVGPPETYSSTEPTSGVTVNENTTAEQSKDITDSQTVSSVQQDFSGISVGVDFTGDDLQPDGSRAESPLVAGSGEEAESPLEASSEEADTEHSEHDPSVKDSEATPLNDRKKAKVRSRKLKIPSMEKMIAKYKSNAPSSEAANIGVTAFGVNAFLSRDNQRMLASVQAAKKRKESGKAGGSAEKKTKKRKPAGRSFLRLDKFEETELDKKAKMRKRYFETADDDEEEGRKAKKNKGLGSKERRRTERSAQPKKTGQHYYATANVKNKNRSRSKDSNARPRKGAKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY71</accession>
    <name>A0A913ZY71_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056593.1">
        <property type="nucleotide sequence ID" value="XM_038200665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200665.1">
        <property type="protein sequence ID" value="XP_038056593.1"/>
        <property type="gene ID" value="LOC119728433"/>
    </dbReference>
    <dbReference type="GeneID" id="119728433"/>
    <dbReference type="OMA" id="RGKTTFC"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="176"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127432" checksum="ED72631F38758307" modified="2023-02-22" version="1">MQSTISEKTLRNLASNIGKEWKALATYLGVRSDELDRIEADHRGTEEQIFQMLMTWWQRRDHSNDSGDSSALCFLQESLRKSGRLDLAESVSDIVEPLTDWNFDVCRDEFIRYYKDAMGVVPLLPWLASEVSKINDIYVKLKITEKENKAGRVAQRDIGSYEDMLRLEFQDGQPVRFILLSGIAGSGKTTIVSKIATDWALQTPGSALSKFSFLVALSMRELKRAPDLTDAVFDQILAKDTKVNPVALKDHLRSHAEEVLVVLDGADEFDKEGSQLPSEGDIIDIISNKVLRGCTVIVTTRPHMVDKLCKLNPSFTCIETTGFSDSGVHEYVQKFFTGEVASVSNELCHNLMESNSLKDLARIPMMLLLICLVWSDAHKLPDTLLEVFKEAMLFMLKRHHFVKSSKFCQEEEAIENELMGFVQALGKAALDGLLLPGQKLVLKASDFGNSKMVDKACSLGILSKERVRSKLHSVQRVTFLHKTFQEAIAGFYWASLFESDNYSFNQYRRQIDEENAFSLEYVLRFCCGANVGAAKTLLIHIVDVFSKRNLESSITRESKNLPKSIVWKPVSLQENKDRMIQRLWLLMHVEAQSRELHNIRKPMDRHRLVFDFDCPGDERTAFGFLVDCASSVSVSFLKELQQVSLSTVSQKCAQIVTTILKHGVMNVRDLTLEFGECWNKQADNRWQLSLGKTLGKMQLENLSISGPSLIEDYDVSAIFERLSESKMSTVQNLTLTSVAVYSRYLKKFLEMQGELRRISLRSQYEKDSRQVWGEALEGIQTASLQEMGVKQCILSDSHEYCLDRSYPNLEILRLIDDDLHAEEIHSVCSLLTKAPKIQELDLSRNKIGHGFPSLVEKLPHLEHLQVLKLTDTGMFSEQSVHLARHLPRMINLRVLNLSCYEYSKKKITSDALITVVQWSCRCPSLRELDMKQCVWEIPDVDWTSHDTPPSQEEESESPDGSADVLETVEDRIRETHQSSIENLDLSSNCLGKSTSGLIELLKQMPFLRNLEMSSMGLVYSDAVLLSEVLQECRVLQRLHLGDNNKIGNIGIGVLLRVIPKLPCLEFLSLPDNDGNPPEMVRKCLQHGHRYRIIRYFHEFNRPQIEAVVEVVRRFERKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ44</accession>
    <name>A0A913ZZ44_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056744.1">
        <property type="nucleotide sequence ID" value="XM_038200816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200816.1">
        <property type="protein sequence ID" value="XP_038056744.1"/>
        <property type="gene ID" value="LOC119728536"/>
    </dbReference>
    <dbReference type="GeneID" id="119728536"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765322" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29362" checksum="76B32B43BD7BA3F4" modified="2023-02-22" version="1">MAFMSEFFAIVVAILSMRALSESNLCPSRSPVKCSCPQEWQLWGNECYRLTPSYYNWDDAKKVCQGMGGKMATPRSLEELNFMVELARKEDGEYYAWIACNDKEVEGTWECDGQEGGEPFLVWADGQPNNWKGNQDCAKLVVRYIDTMDDEQCERWWKAFCVRLSTQPRQYCLSTDTHSRILNSTCLLDHNIREFITEGVVACGSACAQEPGCRSFNIKKTEDGKKICQLNNSTSSEDKDKFQKTDYFCVYSEVCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZB8</accession>
    <name>A0A913ZZB8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056809.1">
        <property type="nucleotide sequence ID" value="XM_038200881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200881.1">
        <property type="protein sequence ID" value="XP_038056809.1"/>
        <property type="gene ID" value="LOC119728586"/>
    </dbReference>
    <dbReference type="GeneID" id="119728586"/>
    <dbReference type="OMA" id="ENPQGIC"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="71134" checksum="CE76AE7BEC4C8898" modified="2023-02-22" version="1">MAEAAARTVLDKISQGHLECPICCCLFKDPKMLDCLHSFCLKCLEEMMSKQKSEVEKITCPVCRREMQVPDGGLQSLSSSFFLSSLVDEVKEQEAVLGDASAPTATCDCGEGKEVIWRCLDCSDNLCQECRKAHERVKSTKDHQIISLGDWQESKILPAEHSKPITRRCTIHTDQTLCFYCDTCDTLICSMCAALDHRSAKHNFLKIDDSIRSFRSEVDNILQKFEKCRQRFKSTENSIVHARTRLQKKLAQARGDIDAKAEAEITKIRNKAKLLTDKVDKIGQERDSKYEKALIHNRKQIRCADQTIAAVNDLMRQADDVELLELKPKVMHNLEFQKELKFEPANHGPSFIGVRCQDVVSDADLGEVCVSEKWQIKEQFGEEGTGDEEFDFATAVACFRNGDIVVTDTNLKRLSLFSSTGRYKTSVAKGDVRHQLEAPFGVAVTHDDLLFVTDQKKVKVFDTELHFVREFTPSGGDGQSESNLTDVAVDSQRVAVADRGRKVISVHNLDGSLIASTSNSMVDFYLAISNFGCLVFTNYEGQSLLCVDFKGKEMFSVKTLMNGKAAKPAGVLCDDDENIYVAVHSEKTGGSEVQRYDLNGAFVATVAQGLYNPVVMAFTPTGDVVVAEVHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0A5</accession>
    <name>A0A914A0A5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057257.1">
        <property type="nucleotide sequence ID" value="XM_038201329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0A5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201329.1">
        <property type="protein sequence ID" value="XP_038057257.1"/>
        <property type="gene ID" value="LOC119728895"/>
    </dbReference>
    <dbReference type="GeneID" id="119728895"/>
    <dbReference type="OMA" id="RSHRCHD"/>
    <dbReference type="OrthoDB" id="10050376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="138" mass="15550" checksum="EF85DF99AEDDB31F" modified="2023-02-22" version="1">MPFSPSSNKASNVKMVVQCEECLKWRVCYAARVLKQDQKQQLELELDTLSYSCGAYFQDIDTGGDDDSVFNHIYVNDKLTCDMPIEAAYFVTFSDPLCFYCGSEHNLEANDGQDPLCDICKASGKQPHSKNTRAFVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0D3</accession>
    <name>A0A914A0D3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057050.1">
        <property type="nucleotide sequence ID" value="XM_038201122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057051.1">
        <property type="nucleotide sequence ID" value="XM_038201123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057052.1">
        <property type="nucleotide sequence ID" value="XM_038201124.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057053.1">
        <property type="nucleotide sequence ID" value="XM_038201125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201122.1">
        <property type="protein sequence ID" value="XP_038057050.1"/>
        <property type="gene ID" value="LOC119728750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201123.1">
        <property type="protein sequence ID" value="XP_038057051.1"/>
        <property type="gene ID" value="LOC119728750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201124.1">
        <property type="protein sequence ID" value="XP_038057052.1"/>
        <property type="gene ID" value="LOC119728750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201125.1">
        <property type="protein sequence ID" value="XP_038057053.1"/>
        <property type="gene ID" value="LOC119728750"/>
    </dbReference>
    <dbReference type="GeneID" id="119728750"/>
    <dbReference type="OMA" id="ETYHEIV"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF126">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275653" evidence="1">
        <location>
            <begin position="25"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49797" checksum="78D7B3369D265B55" modified="2023-02-22" version="1">MKMPKLYIRLIAFVLMLGLVPVAAEQSTDDSARKSKVMLLLLDGMRSDLYGEALPGLKSMELNGVRAEWLTPAYITLSMPCMYTIVTGLYPESHGITFNKYYNLSTGYKSKTFYETLNITDWFNAPGVEPIWVTAIKQGLKAGTVQYPGGNVAIQGIRPTKNSPGVPWQQLGQYPLKGLIDIGLDWLKNDDMDLVLVYSGQPDSTLHGLGIGSEAAKAKIHEVDEAVEYLFEKSRAMGLGNTLDVIVTSDHGHVNIDKRRYVELYNYINASDIQMGLLDYGNTFQIEPVEGKLDTLYDALVDAHPQLNVYKKEDFPVRFHYANSDRIMKLLGYVDSNWYLFSRKTESSFFLAADHGYDNQNPEMRSILYAQGPSFKKGFRGEHLESVNIYPLICDLLGLDPAPNNGSLQNYKAFLDDGSSSASTVRSLGVATLVSMYTMMIALIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0V6</accession>
    <name>A0A914A0V6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057230.1">
        <property type="nucleotide sequence ID" value="XM_038201302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0V6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201302.1">
        <property type="protein sequence ID" value="XP_038057230.1"/>
        <property type="gene ID" value="LOC119728870"/>
    </dbReference>
    <dbReference type="GeneID" id="119728870"/>
    <dbReference type="OMA" id="CKIYISM"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF418">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="37285" checksum="AB7955D0D15857BA" modified="2023-02-22" version="1">METTPSTDEGIIVTSNTTEDNVEKELTSTTLLILVKVMAVLAIFLCVLLNPLMLVTLRRVTSIQPTTKIFMASLTLSDLCNSLCWILPLTELFAGSWLLGDFLCVVYSVTIYLFNGLGIYSLLLLTVDRYIAISRPLRYPSIMTVFRSKTIVFSTWAAVSIICILGLGIHGKKVVSLVSKHNLCLRESYEWRQYLSVTLLVFTILSILIMYAHIAVIARNQARRIAAENQAGNGQGGQRINTRSTTTIIIITGTLIITWIPSVIRLVIDSQNQWEPYDSYLAMMFTNVLLLCNGWLNVMIYYLRNRDLRQAMHALLSDWHRSLQQRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2M7</accession>
    <name>A0A914A2M7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038057626.1">
        <property type="nucleotide sequence ID" value="XM_038201698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201698.1">
        <property type="protein sequence ID" value="XP_038057626.1"/>
        <property type="gene ID" value="LOC119729138"/>
    </dbReference>
    <dbReference type="GeneID" id="119729138"/>
    <dbReference type="OrthoDB" id="9976756at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038010581" description="receptor protein-tyrosine kinase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="122"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="303"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="599" mass="66884" checksum="18D09604C4CA6AFF" modified="2023-02-22" version="1">MALGKRSSCGYLFLIVSFFNKCCSVSSQEVVLSRISRYEIEGQGTEFKCTVGREYYNRDYFSHSVWLLNGYPLFEHPDEFPATLESSKMITLHRNQTGSTLMCLLHPIEKNSTLTLHVMYPPSAVTLHVNTTHSCESETECSADVTIGSRYRFACNASGSSPASNITWLINTKARSGMGQTEISPDWSQSRQDETNEDWETSSRIDLQILPEHHQGSITCRAMFPVGGTVFREITVKLIADDKHDVLQLLAIIIPAAGTVFAVVVIVTVCTLRSNAKRQRAKEVTEVMEEGTMKKCNFPRSKITLFDVIGSGNFGQVFRATADGILQEGVETEVAVKVLKESADGAAVCDFKKEIAIHKTLKRHPNVVSMFGCCTDSEPFVIILELLPGGSLQGYLRNKKQAWTEEAVEGAKPVPPSELLAFASQIANGMEYLSSVGCIHRDLAVRNILLDKDMVCKLSDFGLARDVSETQQYERTSTGMIPVRWLAIESLLDDVYTTMSDVWSFGILLWEIVTLGAHPYRGLRARDVIDSIEQGFRLPNPAHCSEQLYEVMNETWQETPSERPTFRELRETLEGMIPEAPIYLDMANFVADQYVGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A355</accession>
    <name>A0A914A355_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058029.1">
        <property type="nucleotide sequence ID" value="XM_038202101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A355"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202101.1">
        <property type="protein sequence ID" value="XP_038058029.1"/>
        <property type="gene ID" value="LOC119729511"/>
    </dbReference>
    <dbReference type="GeneID" id="119729511"/>
    <dbReference type="OMA" id="EFCFPSI"/>
    <dbReference type="OrthoDB" id="10056927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="12">
        <location>
            <begin position="148"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="306" mass="33318" checksum="4DB7B70AE975E41E" modified="2023-02-22" version="1">MRVFRRGEAPVKTTSSSSATEMECPYDVISQPGEYFVQSSEAMVCTWLFLTGPSAVVELEITELDYPCAEDSFVEFFDGVALQLGVFPTEAGHDLPVQERVNMVCNTGSRVLLSSQNVAMLTYQSPANGGAFRLIFKHKTIQAPCNIFSPDSSGAFTLSNFNKQKNCSFATIYPGYINVLHMAVGRETNEARLKCKGMTDMVQFAEGNSLELSKMNIEQRMCGRTGGKSPTGPEGAVPSPADALHGRDGTAASLVYKKRAQCTSGITIPLMCQMSVVRLVSSGQHDNSITFTFTRETGEKNECVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5J7</accession>
    <name>A0A914A5J7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059005.1">
        <property type="nucleotide sequence ID" value="XM_038203077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5J7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203077.1">
        <property type="protein sequence ID" value="XP_038059005.1"/>
        <property type="gene ID" value="LOC119730267"/>
    </dbReference>
    <dbReference type="GeneID" id="119730267"/>
    <dbReference type="CTD" id="81671"/>
    <dbReference type="OMA" id="EEPYDKR"/>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="52429" checksum="451D8CF7E71DD2BE" modified="2023-02-22" version="1">MDYSKFKVSQLKKELKKRGLRVTGLKQEMINRLKETDQMFQQNNLTPGIGELIKGPRQSQRGTPSPLESEDHHEIREQHRLEREERAKITLLKKPLTTMMYFGLELWVILVGWCHRLWLNRKKVLVTSLLVVSMLVLYHLEGSHQVYVQRMRKQTVWCLYWIGLGVLSSVGLGTGLHTFLLYLGPHIASVTLAAFECQSVDFPEPPYPDEIVCPSEQSTYPMTVWNVISKVRLEAFMWGAGTAIGELPPYFMAKAARLSGYEPDNEDYEEFEAIMEHMSEDPQQQDFATRVKLGIQRLVQRVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAVIKMHIQKLFVILTFSEHHVEALVDLLGKIPKVGPPLQAPFRDYLEKQKHKLHHKPGESVTQGTNWLSWIFEKLIIIMVVYFVISIVNSLAQRYAKRLHDKKRETQNHLHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8I9</accession>
    <name>A0A914A8I9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038059746.1">
        <property type="nucleotide sequence ID" value="XM_038203818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8I9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203818.1">
        <property type="protein sequence ID" value="XP_038059746.1"/>
        <property type="gene ID" value="LOC119730788"/>
    </dbReference>
    <dbReference type="GeneID" id="119730788"/>
    <dbReference type="OMA" id="WLATINS"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000001">
        <property type="entry name" value="NT5E isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="11">
        <location>
            <begin position="339"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="600" mass="65800" checksum="335B6DE7B6528440" modified="2023-02-22" version="1">MMQWIGLRVAVVLATIYLTAAVPFKLTILHTNDVHARFEQFDGYGGECSTQESDDGECFGGVARRVSKIRQIRAAEENVLLLDGGDQFQGTMWFYLYKGQATSHFMNITGYDAMAIGNHEFDNAPEGLSQFLTDVPFPVLSSNIDASLEPSIDGLFHKSTVLTVGGQKIGIVGYTYARTPEISTTGKLEFSDEVTAVQAEVDRLQTEYGIDKMIALGHAGFDIDLKIARKVRGVDIVIGGHTNTFLYTGSAPSAEVPEGDYPTVVHPDYDATANVLVVQDYTFGKYLGRLDVTFDDNGNVTEWGGNPILLDENVPQAADVLQEIEKWAETVRNFSNVYIGRTHVLLDGSCRLAECNLGNFLADAYVRQAIRFPDELQWNDVSIAIVNGGSIRATLYQGDITIGDVLTVSPFGSTVDTVTIKGVYLMEALENSVAEYDPVSRPGRFLQFSGMIVTYDLSQTKGSRVVNAEVRCTECEVPQFVPLDLEKVYKVVMPSYIVGGGDGYSMIRDNVIEHDYGNLDSSVASEYIQWITPATPGLERRILFVDPSDPSDPPNPSDPSPSDPSPSDPDPCGTGSANRIHRLTPLWLLLIAVLMQDFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA94</accession>
    <name>A0A914AA94_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060356.1">
        <property type="nucleotide sequence ID" value="XM_038204428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204428.1">
        <property type="protein sequence ID" value="XP_038060356.1"/>
        <property type="gene ID" value="LOC119731292"/>
    </dbReference>
    <dbReference type="GeneID" id="119731292"/>
    <dbReference type="OMA" id="MIRELLC"/>
    <dbReference type="OrthoDB" id="448621at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052682">
        <property type="entry name" value="MZB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881:SF2">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="19640" checksum="4764A012346288A3" modified="2023-02-22" version="1">MIRELLCKFVFIIAVLFINGAIVHVIGGGGMKFEPDEDAEVYDSGFASSGKMSFTTPDLDDEDHHSLHMPDQLLCDACQILAHMFETKFDKMNEKRPSLKKKLPESDVLDAVDDICNDEFNLVGIKEIKGVKRLSGPGLSTKDVPGIMQGGGKWPGRMREVCNQYAGDLEEENIYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAN0</accession>
    <name>A0A914AAN0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038060496.1">
        <property type="nucleotide sequence ID" value="XM_038204568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAN0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204568.1">
        <property type="protein sequence ID" value="XP_038060496.1"/>
        <property type="gene ID" value="LOC119731397"/>
    </dbReference>
    <dbReference type="GeneID" id="119731397"/>
    <dbReference type="OMA" id="GECIHIP"/>
    <dbReference type="OrthoDB" id="6428779at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036700106" description="cholesterol 7-desaturase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="371" mass="41945" checksum="3752F9D4557DC8FC" modified="2023-02-22" version="1">MAVSKAGVLSFILPVFLAGFVTRPPIIEDSAKQLANHVQNANISAEVVSDKINQVVHSSGFKFLLVYGLAAVLTYLAVQLYKAVTEPLALYCDETKYTYLVDGPADGKSAEERVRDLKRCRKVGDVPPVYPNGWMSILMLSELKKKEHIFVAVAGKNLVVFRGESGRPYVVDAYCAHLGANLAIGGSVHGECIECPFHGWRYRGEDGKRAFVGQAHFTDVSWEPHPTDKHVAVLRMSTKPPYFFNLLNLLANTFHIEQIGPCFAHFHMDSPLLGELQLVLTVTPVGPMRQRIVTTGYTRRGPISFYIGKKTLYEQYYQIWGDLPVWANKKYVRNPPFVKEDHLIAKHRRFFSQFYSENSPKYDPKEESMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABQ5</accession>
    <name>A0A914ABQ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061340.1">
        <property type="nucleotide sequence ID" value="XM_038205412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205412.1">
        <property type="protein sequence ID" value="XP_038061340.1"/>
        <property type="gene ID" value="LOC119732046"/>
    </dbReference>
    <dbReference type="GeneID" id="119732046"/>
    <dbReference type="OMA" id="DQWGQRA"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="839"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="914" mass="95630" checksum="DF796C1B2F075DEF" modified="2023-02-22" version="1">MSSTVPSKLFSYIYGFLRENKLTKTAKSLRKETGSPVHAPKPEDPDLVEILKTYETVSPSGAVKRKAKPDDTPSPAAKKKLKGEESASKTPKTSKTSVKTKDKTPSKTSEKTPAKTEKTPSKTPVTKTVSKKKEKKTPSKALEGKGKTSPGTGTKRKKESSSESSSESEAESKQGKKPQAKKAAVGKTTPQPAAKKPTKDASSSSESESSSSDEEDEKPAPAKATKPAATTPSKGAALQNGDGSSSSSDSESDSEEDQPKTPVKKETQTPKGKKVTPTPAQKKEESSSDDSSSSEDSDDEAKKPATKPSPAPKTQAKSPKVQPAPKTKAESSSSEESSSEDSSSESETEKSSKPAGLIKPAADSQAPAKTPAKTPAKKEDSSSSEDSSSSESDSEDEKPKTVAKPVSKSTPTPTKVQATKTPAKSPAKTPSKGKDSSSSEDSSSESDSEDEKPKTVGKPVARSTPAPSKVQATKAKESSSSSEASSSESESDEDDASKKPASSAKPAAKPPAKTNPKQATPASKAKEASSSEASSSEDSSSDSDSDSGAEPKKPTAQPQKVQQAKPQVVKKSASSSSEEESDTESSSSEEDESPAKTKPAPATPASKPSQAKPAAKSPAAKPKKDSSSSDDSSSDEDSEPETKQTKPALNSKPQTPKTQKAAESSSSGESDSSSSDDDEDKKKPTSKPQTQKTPAKTPTPAPVNGKDDSSSSDDSSSSDDSSSEESETETKKAPVKQATQKATNGKATPSQASKKSKDSSESSSDESSSESEEEKVVMKKVLTKKKPSKSSSSSSDDSDDDDDDDTKPGNQTLPVSTTPAQAKNKQSPATVPRMKKAEPFRRVKEGDHEIDPRLQDNSFEAKRGSRGSWGDRANKDLKVVRGKAFRHEKTKKKRGSYKGGPISTAINSVKFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACV0</accession>
    <name>A0A914ACV0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038061745.1">
        <property type="nucleotide sequence ID" value="XM_038205817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205817.1">
        <property type="protein sequence ID" value="XP_038061745.1"/>
        <property type="gene ID" value="LOC119732360"/>
    </dbReference>
    <dbReference type="GeneID" id="119732360"/>
    <dbReference type="OrthoDB" id="10139965at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="103"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="511" mass="56945" checksum="CDCAE215230FD8C0" modified="2023-02-22" version="1">METTTSWLLTEQTDSINASHQDNKSFWSNASSLQSISTLLQSSDGFDSTIPNEINESLYTNGFWSDPYYTTEPTSLSEVSGKPAMFFVMVSLRSVVVLATILANVLVLYAYATTKKLRTYTNYYIVNLAIADLVSGGFIPIRGVYREFSKDWPFSEAFCACSTCVDHIFLHATFLMTLTICYDRFRATNMPLKHLSEKTLRHACMLIFLAYIVPVFLWTTIIIILPYSGVISRVQPPQCYGPYAFYPALLIFTILVLSWVPMISTVILYAFVYCAVIRKGIDKNRVTGKKTVSEKKSKGVASETKSGDPRSRSYRLDTELSERAAGTKHPAEQTNSEGRVHSISAGLSQGLANPAYEETEEDVHRASDQPSLPGPVLTEKTLSAGPPRRGSTGAPARFAGRASRRESRLASLRATRTLTYILTTMVVSALPWSVFALWAAIDPLGLPLRYNTVFNYLGWMSHFSSTVNPFCYAVGNPLFKAVFLRILCCRPITAPRNAERSSDRHSRTSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD08</accession>
    <name>A0A914AD08_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061717.1">
        <property type="nucleotide sequence ID" value="XM_038205789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205789.1">
        <property type="protein sequence ID" value="XP_038061717.1"/>
        <property type="gene ID" value="LOC119732329"/>
    </dbReference>
    <dbReference type="GeneID" id="119732329"/>
    <dbReference type="OMA" id="YHESELQ"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="53"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="612"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1228" mass="133542" checksum="59987CC944589D69" modified="2023-02-22" version="1">MILDNTLTKLQSEILTVIHRPIHDNMASITSLALKLLIFTACLQSGEGQFVITNTTSGPVVGVKTSFPPLTDQLVTRYTAIPYAEPPTGERRFAKPVPKSPWDDVLNATVYGPSCPQPGLNISSMDAFLPNTDMDEDCLLLNVYVPDDAVASSGPLPVMIFIHGGGFFTGQGMLYDGTVLALHGQVVVVNINYRLGLFGFLSTGDDSAPGNYGLWDQRLAIQWVKDNIANFGGDPDQITIFGESAGGWSVTYQMISPLNDRTLFQRVIAESGVVFPNLVIPATVARFQAFTLGSILGCNLPAVSTSRELVSCLRGISVETLLTQTYTVQSSATIDGEFLPANINTLLAHPRVTQYDLIMGFNDQDGSVFLSQVNTDYTEEELRADIQLFLLTCQCENSQEITNAVFAYYFGGHDLEDPDENVLRYLDVTGDQFFKVPSINFLTRHAESAANTSTYFYQFTYETGKEFLLPPEWLGLISGAPHALDIFYVFGFIKALYPNDTDAAILSNRTMDYWTQFARYGNPNGAGLSALPEWPDFGTENGSYLILDPDLKTGYRFKPNKVAFWNDYIPTITEPASYKKTCSYEVPVRRGTSLKSDNMTVQVTSKGGEVLGSVVGALRMADKAMGGLEIAEFLGIPYAKPPLGELRFKPPEDKGKWGDEPLGIPEKLPPACPQDVTRDPWMVRLGFNQTSEDCLTLNIYAPTQDPNDPALPVLVFIHGGDAKYGTSSVYDATLLASRVKAVVVVMNYRLGALGFLSTENEAAPGNYGLHDILAALKWVNKFIGSFGGDPERVTVQGYGSGAVLAHLLTLSETAKGLFNRAVLMSATAIFPPVDNPVLPSVSERAKTLASKLGCPTETSDMMVSCLRDKPAADLVSITISAPFGLAFPTVVDGDLITDTPLEMLKAGRINDVDILVGLAQDGFAGVAFAFTGLDCPSTAEVQKYIETVSTLSFTNADKTAFALVTEYIGKGGLDDDCQTRGSFRQFINDYLSYWSTLEAARLHADAGHSVYFYSFDLKPPAHHYKGLLPPQVGPTFADDLQFLFGDPYSPLVDELQLSYRLEDKRFTLELMAFLKMFTYNGAPGPSLSGVEWPAFDSANLTYMSLTDCPQVLSGNDNNWQHLLRFWASYLPSITAPAPTPAEPTPCPPDPEPCTVSLGGLRLPLSEASTVIAALIGTTVGVGVLAIIFLGVCVANKAKANGAAKRKSWMMPGVDLTHIETMPDDDPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD22</accession>
    <name>A0A914AD22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="13">LTA-4 hydrolase</shortName>
            <ecNumber evidence="13">3.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>leukotriene A4 + H2O = leukotriene B4</text>
            <dbReference type="Rhea" id="RHEA:22324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="EC" id="3.3.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; leukotriene B4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.6" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038061643.1">
        <property type="nucleotide sequence ID" value="XM_038205715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205715.1">
        <property type="protein sequence ID" value="XP_038061643.1"/>
        <property type="gene ID" value="LOC119732263"/>
    </dbReference>
    <dbReference type="GeneID" id="119732263"/>
    <dbReference type="CTD" id="4048"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004463">
        <property type="term" value="F:leukotriene-A4 hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="14">
        <location>
            <begin position="467"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="567"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="619" mass="69870" checksum="FAE86E86FCA6ADE0" modified="2023-02-22" version="1">MAASTRDACSFSEPQRIITTNLSLLWDVNFTERKLSGSVQLDLRILSDDVSYLVLDTSNLEIFSVCDETSGEKLAFHLAEPNKAIGTALHIKLPSRAQNKGAELRVRISYETSPSASALQWLKPSQTAGKKYPYLFSQCQAIHARSMVPCQDTPGVKVPYQAKVTVPMELVALMSAVGQGEEPCPTDASKKTYIFQQTVPIPSYLIAIVVGLLESRTIGPRSKVWSEKENIDQGAYEFAETEQMLQTAENLLGPYVWGQYDLLILPPSFPYGGMENPCLTFVTATLLAGDRSLANVVAHEISHSWTGNLVTNCSWEHFWLNEGFTVFAERKIAGRMHGEKQRHFEAIGGWKDLQNAVDRYGATHPFTHLIPSLKDVDPDDAFSSIPYEKGSTLLFYLETLVGNNDEFEAFLKSYINKFKYKSITTQQWKDYLYEYFHDQQSVFDVVDWDAWFFQPGMPPVKPDFDTTLSSCCSELCLRWCRSATCDLTSFTSDDLGSLTSKQVIEVLSQLLLEPPLSSEHIQAMEKTYRLGESGNAEVKFRWFRLCIRAGYEPVTQKALDFAVQWGRLKFTRPIFRDLFKFAVARDQAIATFKQHKDDMHPITAAMIGKDLQESQQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEN6</accession>
    <name>A0A914AEN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062193.1">
        <property type="nucleotide sequence ID" value="XM_038206265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206265.1">
        <property type="protein sequence ID" value="XP_038062193.1"/>
        <property type="gene ID" value="LOC119732639"/>
    </dbReference>
    <dbReference type="GeneID" id="119732639"/>
    <dbReference type="OMA" id="YNTIQLH"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037227052" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="19407" checksum="9725A846F98EE595" modified="2023-02-22" version="1">MRKVWQVLLVLFAILNQKSLTDGRCRRIARYTVYDCEPPWQAFKDNCYLRVAEGTNYTDAEQHCQSYSKQWRPTRLASILSDDENQFIATLIDSSDTWIGYNDLAVEGVYTWLDGSPAGYTNWKPGFPVGDAYGNQDCIHMFGGPQWKEFYCNGMMNFVCKMPRHTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJD0</accession>
    <name>A0A914AJD0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038063666.1">
        <property type="nucleotide sequence ID" value="XM_038207738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207738.1">
        <property type="protein sequence ID" value="XP_038063666.1"/>
        <property type="gene ID" value="LOC119734307"/>
    </dbReference>
    <dbReference type="GeneID" id="119734307"/>
    <dbReference type="CTD" id="80142"/>
    <dbReference type="OMA" id="DYCLTEG"/>
    <dbReference type="OrthoDB" id="423541at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST C-terminal" evidence="19">
        <location>
            <begin position="231"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="43544" checksum="B07B69EA89B820D5" modified="2023-02-22" version="1">MATYTTTRFFRSLNNPRKFLLLAYQNAAGKPHMRANNIRNISGYFRLDLNPDKSWKSLCAGLGIASGLFCTSYVLKHNIRRFSSASAQSLETNETSQRFLSDVDASRLKLTLYQYQVCPFCCKLRAFLDFYGVPYQVVEVDPIRRKELKFSEYRKVPILVQEGPANEKTQLNDSSVIISALTTYMSTDEKDFQRIVSYFPRMESEDKKGKKSVEFGNKYEVMTGKPGRTVNEKEEKKWREWVDGVLVHYIPPNIYRSPSESLQAFSYISSHSQYNTMQQFVIKYAGAVGMFFVAKKLKKKYDIPDDVRSCLYSAADDWTKAVGNRKFMGGDKPNLADLAVYGALSSIEGLDAFNDMLYHTNIGSWYQRTRKAVKNKDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJX6</accession>
    <name>A0A914AJX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064285.1">
        <property type="nucleotide sequence ID" value="XM_038208357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208357.1">
        <property type="protein sequence ID" value="XP_038064285.1"/>
        <property type="gene ID" value="LOC119734797"/>
    </dbReference>
    <dbReference type="GeneID" id="119734797"/>
    <dbReference type="OMA" id="AEHNWHD"/>
    <dbReference type="OrthoDB" id="10012954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="557" mass="62726" checksum="1ED0F6792F7F0012" modified="2023-02-22" version="1">MFWKAHYIFCEEGRVIKPDKAQTQSGLDLTCTGTGLGKKHSRRSKMAMLVLGVVCLLLAHVSASPPKKNALVIIADDAGFETQVYNNSVCKTPNIDQLAQSSVVIRHAYTSVSSCSPSRSAILTGLPQHQNGMYGLEHTVHHFRSFDAVQTLPVILKPAGIKTAIIGKKHVAPAEVYKFDYEETEFNNPMLQCARNITRMKEFVQTFLSTNTTKPFLLYIGFKDPHRAGPTDIPKYGQFAERFGNGQPGMGDITDWKPAQYEPSDVIVPPYLPDTLATRTDIAAQYTSISRMDAGVGMLLKELQAFGHLNDTLIIYTADNGIPFPNAKTNLYEPGMGEPMMVSNPYVKQRWGQYSEAITSTTDIVPTVLDWFGVSYPDYVLEGKKVTLTGKSMLPITSAEPTGWDHIFSSHNFHEVTMYYPMRVMRDRQYRLIHNMNYRAPYPIAQDLAACPTFIDILNNTAAGKPTKWYKTLDQYYYRPEWELYDVTNDPLEKVNLAYDAAHKSTLEAMQTAVCDWRHATNDPWRCFPEGVIHGPKCIDLQNEPPKNKYAKEYNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKS3</accession>
    <name>A0A914AKS3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064193.1">
        <property type="nucleotide sequence ID" value="XM_038208265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208265.1">
        <property type="protein sequence ID" value="XP_038064193.1"/>
        <property type="gene ID" value="LOC119734725"/>
    </dbReference>
    <dbReference type="GeneID" id="119734725"/>
    <dbReference type="OMA" id="KTYREHA"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="134"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="318" mass="35932" checksum="AA6BB1E0DB29F224" modified="2023-02-22" version="1">MADAPSSFASPQEELAYWKKLADDYRKNWEEAKEELDEFQISSQELEAELETQLESAEGKVKELTVAKERLQNEADILKEKLEHSQNEYLRQINELQDELAQIKAIREELSKYIRELEQHNDDLERAKRTTVTSLEDFEARLNLAIERNAFLENELDEKESLEVTVQRMKDEARDMAHELAVKGKMMTVRNSQVLPDNDRMDTTPQKHGNTRLPETDNKVLHEAETNTTPGLNRAETGGSAGFTPLTPSARISALNIVGDLLRKVGALESKLASCRNFVKEPPRKANSPVDSPRAAKRANRTGTTSSSTLQGMVKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKX6</accession>
    <name>A0A914AKX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEFM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064650.1">
        <property type="nucleotide sequence ID" value="XM_038208722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208722.1">
        <property type="protein sequence ID" value="XP_038064650.1"/>
        <property type="gene ID" value="LOC119735033"/>
    </dbReference>
    <dbReference type="GeneID" id="119735033"/>
    <dbReference type="OMA" id="ESPQMAQ"/>
    <dbReference type="OrthoDB" id="5949570at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006392">
        <property type="term" value="P:transcription elongation by mitochondrial RNA polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039150">
        <property type="entry name" value="TEFM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053:SF2">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="39169" checksum="A8E75515DF5EFD58" modified="2023-02-22" version="1">MSSFAKLCCRLRFSAQVTCSRSVRRLCQGASNSKDGVLLSGKSDLSNVGKSDDDEDSTKIVQLVNTASEKDLAAMKHVSPNIATCIVSHREANGPFAEVRELLKVPGIGRQTLQRICRGILKPPLQVDVSGNGATTEAQQAGIAASRIESLQDIVAVDVGLRHLSWVYMTRDRQVWQWRVKDIVDIKAGKWDPPAYHKMVTDAIAEMPNPDLYVLEHQPYVNANKATYQMLLFQRTLQSMLFTALNHDQKETGTPHVISMLHTQVGRHFGLQVGGTRMSGQDVVAKILREEAEREDENDEDLPARLSWEDAETFHSATKHEKEHLANCLLQAIAFYDLVVDRVETDRAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANG8</accession>
    <name>A0A914ANG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065153.1">
        <property type="nucleotide sequence ID" value="XM_038209225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209225.1">
        <property type="protein sequence ID" value="XP_038065153.1"/>
        <property type="gene ID" value="LOC119735512"/>
    </dbReference>
    <dbReference type="GeneID" id="119735512"/>
    <dbReference type="OMA" id="ANCKETK"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49280" checksum="C9B5732CCD89BA16" modified="2023-02-22" version="1">MELFETPTVRLSLYNKGTTIREIAQERTRSKTEPNRTDLEDPFFIYDLGDVVSKDNQWKKSLPHVQSFYAVKCNPDPVFLRLLIGLDRGFDCGSRKEIETVLDLGASPDRIIFAHPFKQESHLRFAREKGVRLMTFDTGEELHKVKRVYPEARLLLRVVFDDSSCYMNLGVKFGCRESEVRPLLELAKDLGLCIYGVCFHIGTQAGNPRVFREAIRYTRPIIDKGRRLGLDMKLLDIGGGFPGRLYPEEPFEKFAEAVREALEENFPPSSGVRVIAEPGAFYTRSAGYLVANVMAKRIYKSRGNKDTYHTVNDSTDKAISMYYLNVGVFNAFNGPAAQFVPTFFEYPEPLHPKESGEKQQLKPSCLWGPTCHPKDVIFDKCMMPEMESGDFVMFHDMGGYVTSCASGFNGYEVPPMSYIAPKDSRPLLERIFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANT6</accession>
    <name>A0A914ANT6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065412.1">
        <property type="nucleotide sequence ID" value="XM_038209484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209484.1">
        <property type="protein sequence ID" value="XP_038065412.1"/>
        <property type="gene ID" value="LOC119735673"/>
    </dbReference>
    <dbReference type="GeneID" id="119735673"/>
    <dbReference type="OrthoDB" id="10590419at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037363624" evidence="2">
        <location>
            <begin position="21"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="50949" checksum="64E6BBB7A0486B32" modified="2023-02-22" version="1">MKALQYVMLFFSGFCHVTSASSDSSHVYLQRGKPGEIPNPHVTGNSTNLEKISSAYWYKLTSEGKPLLISNFEGSIIPRTKYIKRFNMTENFSLIINNVTDRDGGQYISRVVKKNQVLPESSVDVTIFVSPSEPAPWIEECGVPKDRKDYCMMQLPSEETFFYLMCHVTGARPAVDLHLRRVHADGSSEAVDQVLHIVRREDSSQYGAIGKDKALFSTMLYFNGTFHGNTTLLCIATGLAMGRNNGSAMQVHISKPLDDTHVPSTARWITEVEGTGRLVLEGISIAALCAFAVGLLLMLVLKKTVCRMERFQQAVPREQQPFLLNDPTTKCGIPKPQMDSLKENIGKVAYVGLTDPQAERRVFSPDEFPNPTLEIGVGLGILCKETRTSEGRTVPTVKFLHLFQEYYAAYYLSTDPATLLPQVCGETIPRNEHLLRFCREMSDEAARIIDELHQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP27</accession>
    <name>A0A914AP27_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065194.1">
        <property type="nucleotide sequence ID" value="XM_038209266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209266.1">
        <property type="protein sequence ID" value="XP_038065194.1"/>
        <property type="gene ID" value="LOC119735531"/>
    </dbReference>
    <dbReference type="GeneID" id="119735531"/>
    <dbReference type="OMA" id="YKLEFAN"/>
    <dbReference type="OrthoDB" id="10125068at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037333893" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="18417" checksum="7B9459BCCD8D4B11" modified="2023-02-22" version="1">MLLGVLFLLFLTSQEVSGLWGDGSQDPTYSHLGFYQKNLTCNDAGTTCQLCYTAHAHDGKAYLHVIQYTTEPYKLEFANLAGRFEDKYSIIQDDPNQTFRLCSELQMEYSPMRDRKLVICLDTRFPSGVVVPETCASPIAVTSLHFNYGDKEMRGQQVLVCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQB0</accession>
    <name>A0A914AQB0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-associated and SH3 domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065611.1">
        <property type="nucleotide sequence ID" value="XM_038209683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQB0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209683.1">
        <property type="protein sequence ID" value="XP_038065611.1"/>
        <property type="gene ID" value="LOC119735766"/>
    </dbReference>
    <dbReference type="GeneID" id="119735766"/>
    <dbReference type="OMA" id="YNFPTDH"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11791">
        <property type="entry name" value="SH3_UBASH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14301">
        <property type="entry name" value="UBA_UBS3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000053">
        <property type="entry name" value="Ubiquitin-associated and SH3 domain-containing, A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="239"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73520" checksum="596000E1C748A0BD" modified="2023-02-22" version="1">MASAAGIINHRRTIRQASLKSAASASDILMSMGFPKHRVEKSLAATGHQDIQLASDWLLDHVDDPTLDEAIPREYVLYACPVGPLGESLDEFWTKSLQHCGRNGAHSLLPHVTLCSFFPCDDSKVEMLTAALQEAVETLEDKAPETISLEHYSSNNFIGLFVEETHAEFMRILTNQFKAEALVKAGVKVDPHKKQLHMTLAYQFNAAHHDVLEKLSKEVNIEAAARWELRLYSRDPRAAKTEVLRVLYSHTPRANDELELIPDDYIFMSSSDNRGANDDGWYKGTSHQTGLTGMLPGNYTEKAPESDTWTVHRVIPLTKSLSSNPALINLDDKVPSPPTPLGADERRSSQYKTPEGLLQQSEEEASKYANLFKLTKTPARSNSIPLATTTDLPTTPRRLFVIRHAERVDITFGQQWLQHSFDDNGKYNRKNLNMPKRVPVRSGGSLAFSKDSPITEVGKFQARLTGESMRENGIVISHVYSSPALRCVETAKAVIDGLNPLEPLKIRVDTSLFEWLAWCKGVFPKWMTLAELEAHGLSVDMNYKELISASDLSLQENCQSYYKRGDTLLRREIKEHPKGDILIVGHASSLDGCTRYLQGLSARPALEFSKIVQKIPYCGAVALQEYQDFGIWDLITPPFATLTHAPNGRFDWHIMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQU4</accession>
    <name>A0A914AQU4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065776.1">
        <property type="nucleotide sequence ID" value="XM_038209848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQU4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209848.1">
        <property type="protein sequence ID" value="XP_038065776.1"/>
        <property type="gene ID" value="LOC119735903"/>
    </dbReference>
    <dbReference type="GeneID" id="119735903"/>
    <dbReference type="OrthoDB" id="10052386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="19909" checksum="CE4B2209C3F00DD5" modified="2023-02-22" version="1">MGLSRLRAAPAPCFKIAAYGKDDFVTGSDLSDLSDVSDEEFDENDVADIDNESEDDGRQYCVCGEPSTMEMIACDDDQCTVVWWHIAALEFVPIQSQIPGNDTAITYCKFLKSWKVDCSDETARTFLQYTNDWIDKQNRGGLFRVSDGVYLLFRSMEHETCKYLTKNNLKTFSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARH1</accession>
    <name>A0A914ARH1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066650.1">
        <property type="nucleotide sequence ID" value="XM_038210722.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210722.1">
        <property type="protein sequence ID" value="XP_038066650.1"/>
        <property type="gene ID" value="LOC119736710"/>
    </dbReference>
    <dbReference type="GeneID" id="119736710"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409979" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="479"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="585"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="780"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="879"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="980"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1257"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1429"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1544"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1725"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1817" mass="200107" checksum="3ACEC1F61191F900" modified="2023-02-22" version="1">MEDRLHFILLFLLLGPFTGVSAVVDFTCITKPRIDIDSEDTYIAAYLNGSDAELSFARTTFTRTGTDTHDPPPPLELPLNSSKTSMASEGNQISILRLPAAGGKTRIGVFACKATRDDISIGTVIMSKNADFLPSRVSQTVNLGDSVNLTVTATNQSSTSTRWRKDGGNVTRNRRGSLYFDFSNIDASDSGVYEVHLAQARQQGNQALMRLIVRECKEHKWKAFSCNSYCPVCFNGGVCDDKSGDCICPPGFSGQFCETPEGPNCFGQSGSFRCDSLELGGGPTCAGMLFCLPDPYGCSCAAGYQGIDCNETCAAGFYGADCAQTCHCMDGVTCNEFTGECFGDCASGFMGINCQEKCLPFNGNVASCNTTCTDFLDPALDSFSPQIVASFTSFHNELTRTFLWQPMNCSNGIMIVNYVYKFGSLESQKEPEAERAEGNSVHVPVSCVNILYEFEVAAETTKGIGRFSVKNRFSSFWQVPDTIDGLTVNGNRHSNLDLTWDAPGTSHDHPCPVSDYLVTFYLINLEQCLDVHQYGGSLNTNDTSITLHGLKAYSTYNVSVTPRNEAGNGTTSFLQVTTGETYPQVPPEFNSSSATTDSITWTWNPIPCGSRGGNITGYATNLTGPFGIIDEGNVSSTSVTHTGLEPCTNYTLAVWAYPSKGRRQPLTMRQRTANDVPVAVSGMSIRVISHERNEFDVCWTPSEGPCPATSYNVTYELIKMDRCRKQNPLILTHFATVDTTNVTIHLPAYYSKYTVKVAPINEAGPGEENFEDIDTNESTPTAAPVIRSAATNDNVTFFWDPIPCGSRRGNITHYEYRFKEQIPREQEKNIEKKNISRLSVTFGDLSPCTTYSIRVRAFTRIGAGPWTNWTQQDTVVIDEIQELNLEPSTNEIKASWTTAGSEDNPCPVTSYRVSYQLLNLEQCQPQTDPALTNLEIVNGNNTDITLMHAYSTYSVQVVPANNAGAKYMKNKTVTTNEGVPLAAPEIDKMLPSNQSVRVSWNPIPCGKRGGDVTGYTYELRDASESRVETADTTAESVEVNGLPQGASYSFRLRAFTRVGPGPWKEVDFDIPKDDTTAPSPPTQPGSSPAGLVLGVVVFLLVAVVLALVIAIIVKKQRQRGSHAICVNGNQDEVELENLPSTSGHKASVDASATEGLSTDEPLTSSTNPPKSTEQQAVAVSPKAGPSTTSTDSASAPGPSTTNIKASVKPKSYAKSATKPKPKASAKASPNFSQAGPVAMAHLAEYIKSRTAGKVNGFQQDYESIPGEQMHSWRVAKEDQNNRKNRYQNILPYDHSRVVLDCLEDNSQSDYINASCINGYKHESKYIACQGPTEASADDMWRMVWQERVGKIVMLTNLIENGKCKCDQYWPEGTADYGELFVRKTDQTKHANFIVRTFHVSKSSEPEGEYRELTQFHYTTWPDMKPPESSPLLQFVRRVRETDTSQHGPIVVHCSAGVGRTGTFITVDSMLEMAEEEGQVDVLKFVSDMREQRFLMVQTLDQYKFIFDALLESSLSENTAISADRFHQSYAKLKKRDKKTGTTGIESQFQMLESFTASPSEEQCMGGRSAANGDKNRFKDCIPKDNTRPYLMTKGDEGSTNYINATFLDGYNSKHAYLATQAPLPNTRGDIWRMVFDYKASCIVMLNSMDNDPSVVQYWPEKDNLEFGPLTVTLTREDRHNEDVIIRQFDVCHPLSKNDEVQSVCQIQYLGWPSVKEVPRSPSSLLKVLEAVKMWTTDHPDGPIAVHCIDGVGCSGTFCALLTLLDHLAVEKVVDVFQAVKKLRTTRAGMVNTLAQYQLCYQVMQTYLDSSSIYENYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARV5</accession>
    <name>A0A914ARV5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066507.1">
        <property type="nucleotide sequence ID" value="XM_038210579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210579.1">
        <property type="protein sequence ID" value="XP_038066507.1"/>
        <property type="gene ID" value="LOC119736565"/>
    </dbReference>
    <dbReference type="GeneID" id="119736565"/>
    <dbReference type="OMA" id="CYENTHV"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="77"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="246" mass="28016" checksum="1321C40A559F35DD" modified="2023-02-22" version="1">MFWTAAACPCFIGQEWDPATNRLRGAAPFKDPCQCTSVELGGVNVIRPQRPFRVSYFDAPLQLPEIRMRLNCSVYACSEEGPLGMEDGRIADDHITASSYYRNMANHGPTRSRLNTQGYASAWCNDEQTDPDHPWIQVKFDSEVYVTGLVTQARGGDSNNGHHQRVTRYRVTHSRDGRSWDHVTGADFKSEEFPGNVNEGHDDQVTARFGTVLRTRFLRIQPTDWNYHCSMRFEVLGCYENTHVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS07</accession>
    <name>A0A914AS07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF-related serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SNF1-related kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038066835.1">
        <property type="nucleotide sequence ID" value="XM_038210907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210907.1">
        <property type="protein sequence ID" value="XP_038066835.1"/>
        <property type="gene ID" value="LOC119736890"/>
    </dbReference>
    <dbReference type="GeneID" id="119736890"/>
    <dbReference type="OMA" id="CGEPPFN"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000166">
        <property type="entry name" value="SNF-related serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="475"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="611"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="674"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="813" mass="89160" checksum="2A3297F4CB1F4D9D" modified="2023-02-22" version="1">MSGAAAAYKSGYDGKIAGMYDLEETLGRGHFAIVKLARHVFTGQKVAVKVIDKNKLDDVSRAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMQHENGLSQDLARNYFSQIVSAISYCHKLHVVHRDLKPENVIFFKKQGVVKLTDFGFSNLYMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDVWSLGVLLYMLVCGEPPFNETNDSETLTMIMDCKYYLPDHISEECRNLISSMLQRDPEKRLTLEQIFNSSWLKQGGEAKPMEPLITRHDITKSVHDSIVERMISGNVADMATIIKSLESDSYDHITATYFLLAERKLKKQVGAVSDLKAEDNSLRRHSSVQPQLASLALSPRTPLPDHPTMDKPINNNISHLCSPVTTQPVSKPISIPLPPLAASPALAAMARSNSEEEVSCSPRRHRMEREHLTIHPRHGRSIVKEGLQSLEEEEFQHIADEELESTEEPMISPSSSADGSWGKNRRSQGTNNARPNIQSTRLNPTVLNQITEEEDEQESDDERPSGVDSLLVTRQIRHRKTVPSKDTPHQIKTSTKMAARGGYSSSDASDDDTDTRRRSEKFDIPPKGQRRGSKDGPPNGGSSSGAGSNNGPGGGTGGKYTGSNSSGGGTGGDSNGGNPGNNGNAYERKKSNELRESLKQSNLSMNSSNSSSSYSISKFAIDPNNTTPSDSDDPSSDAVKSWSKKDNLSHSDSNLYIIPKDSDKSNIQNGSPVKKQLKRDSSNLGGKNGPDLNSNAAATKPTKGRNKEIRKKRNRIGSIEADESPLKPGGKSDSSCCRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS40</accession>
    <name>A0A914AS40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038066274.1">
        <property type="nucleotide sequence ID" value="XM_038210346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210346.1">
        <property type="protein sequence ID" value="XP_038066274.1"/>
        <property type="gene ID" value="LOC119736304"/>
    </dbReference>
    <dbReference type="GeneID" id="119736304"/>
    <dbReference type="OMA" id="TCYLRDK"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="468" mass="54002" checksum="F2723C905B11157D" modified="2023-02-22" version="1">MEATSPIPKKQRHLSISQPSTPMSKCFALLCLAGTMYVFFLNHIVLPGSGMHHRAPGPHDIARHKRALLVDDSFYIRGDPLQGDHTCYLRDKLQSLWMPDLHSVFSDPISGQVVFVGLKLLKHRWHGDEFRCEFPDGQVSRTHVLRDGRSSGYFPQYVVVLTCPIPDTFRWRARFRLNLRRVPTNTSYVNVTVCTSGVSPEKRYKLAICTMVKNADSFIPEWLTFHRYVGVEHVFIYDNEQVEKSNLTRTLNDFIDEGFVTVIPWAHSVSPYKTYLEVQIAHENDCIWRHKHDVDWMIKIDVDEYIQPMDANRTHVITDYLSESIFDHVAAVRIQNWFFGHPPRIAPRGDSVIERNRWRSKLPTLQNTGHDKNILRPINVHYFKIHSVKLGGDVISADPHTELRLVHYRSDNLRARRFSLPDFSVKDESMVKLRNAALSSLMGQDSTTVECFTSEMDINMNTTSDEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWM0</accession>
    <name>A0A914AWM0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068103.1">
        <property type="nucleotide sequence ID" value="XM_038212175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212175.1">
        <property type="protein sequence ID" value="XP_038068103.1"/>
        <property type="gene ID" value="LOC119737671"/>
    </dbReference>
    <dbReference type="GeneID" id="119737671"/>
    <dbReference type="OMA" id="LRIDECK"/>
    <dbReference type="OrthoDB" id="10063844at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="946" mass="106131" checksum="F338A00F4C1F1C8A" modified="2023-02-22" version="1">MGKTKPVAQRRTRSSAGDSSWSQFTKSCKCIMHDVFKTSESPKLFNIALKSHPTRKLQWLLDKKYLSPRAKHVCIDCLDQAPSTSGTGSKRDTTGKKDPSQLPEEEEPSNSESAIVGEILNLIANRKLSQESVTRVCSALGNLLSSDILQDSKAVQGSYKNLENLLDLNCVEYLGERPPALVSFLSSISNVTIDKDQQNAKKTNGLCLVIENIYALRNANFVGPLSFSQGLVKWSINGSKTTHALDGASSASGSVTSLKKVLQNSSAKSNVCFSSGDVDVFADNTQRIGKTGRVRTGGTTPANVVTNVVFIQSRPASNLQTQGQLAPSHWLDKTEDVADKITAFEKELNDNVFRPYRHMCQSKFIEQVKSELHVDDITGESKDHVYYSCSAQEQDCVCPKCCKVYDKVTVECPGCGYNPVNVPDRSSMYGDVPSCHSKEKPAVKMGEIIPINPNSKATIKEVLLNLKQQAGVGTDRSWIRVGFDGVPYRIANLLIKNTIMCEVCNEHIDISVTPFDAHCEIKHPGVYDIGSKKLLDDILLTPGAGHAEINLLRAIFSLTRVIFMEHIAGCLGFCSKRAKDFVIRGSNHHVTWQIFDIVLKAFALELCYTYVSQNREENENFLPTAEDFVMWKNTRVINPNFNLIYDLIFHIFLGVKCFRSGIRRNNSQHAIAGRQKTAPIMYIGKHGIYQPLLFRDMQVRVEAPPDIKKYIEENEAFSRSGNNLRGEGGDYVTENENRSLKSILPPGVPTVERWQMASRCSANLQKNRKAVFQRAGFQDPGEQRGSVFNRELEVQAIRKEIRLSGMLKNPYEEIPLKSIEGKLLHQDFVNVYNTALENYDAYKKSPHAPNLQPVFVTSEDEQMYNDMNNWTARKLTEETMKLLEQFSDQDSADMYREMHSDVAKAAKSVKIQFYQDISQILNLERELLAFGNEDIEQKDDDMEQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWP6</accession>
    <name>A0A914AWP6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068147.1">
        <property type="nucleotide sequence ID" value="XM_038212219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212219.1">
        <property type="protein sequence ID" value="XP_038068147.1"/>
        <property type="gene ID" value="LOC119737683"/>
    </dbReference>
    <dbReference type="GeneID" id="119737683"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="367" mass="41523" checksum="7AD18B2A61C227A0" modified="2023-02-22" version="1">MASATTTKKKREGSGKNCAVIGCKNTSKRLRKWKLATCELHAPETHEYCVCLQPYQMHRFPGGSSAEAVAKRQQWVKNINRLDFKPSKYSTVCSLHFFEGRPTPINPNPTINLGYNSNVHFEGHHFEPHRVDGKRKLKYNAVPLIFGEKAQQVTLSGFRPILPIPVPMPELLPANTVPHDHAYSASATPQRMPVVFPGSDSKDSNLNADEQLHADDSDTQEDMATSDSLTADSTSDNLTKMRERIKTYQAKIHQLRREKGTILKKKNRLESSMLKMFRSDQIEALSRGGMRGIQWSKETMNMARRLWQMCGSNGYEFLLQQHYPLPSVRALQRAQEEQRASPELDEVVGTSRATLLPQEMFGSGFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY17</accession>
    <name>A0A914AY17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear protein localization protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068156.1">
        <property type="nucleotide sequence ID" value="XM_038212228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212228.1">
        <property type="protein sequence ID" value="XP_038068156.1"/>
        <property type="gene ID" value="LOC119737692"/>
    </dbReference>
    <dbReference type="GeneID" id="119737692"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000012">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="219"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="602" mass="67559" checksum="6A07CCBBC6D8925A" modified="2023-02-22" version="1">MPNEIIVRLQSPEGTKRVSVPMAMTLYKFFQKVSEAVAIPVDQFKLFADRNKTKELRPTSKATLNSSKIKHGDMLYVTYQTSSYDGDADKPSVSTSSVVEDDVDQFIAKLDGKIYRERDDQLCHHGVNAKCVHCVPLEPYDERYLQEHDPPIKHLSFHSHIRKLTGGVDKGKFAFLENISLKIKPGCTEHAPWPGGICTKCQPSATTLNRQTYRHVDNLMFENPFMFNRFLDYWRKTGNQRIGFLYGKYEHHKDVPLGIKATVSAIYEPPQRSTVNSLELLPDHNAEAVEFVASKMGLRKVGWIFTDLVADDLTKGTVKHVRNMDAHFLSAEECIMAGELQNQNPSPCKLATEGTFGSKFVTCIVTGDATNQIHTEAYQVSNQCMALVRDNCLVPTRDAPELGYVRESTSEQYVPDVFYTEKDGYGNSSKSLARPLPVEFLLVDVTCGFPKDPMYTFNDTQTVKHFPVENRSELGELQDLGPLAQYMKQFSGEQFLEAMLDLHLLIYLATMQMLPIRDHMGPLLDALRNQDSELARAWSKSEQWATLEHFMAAQGPSPTSTIADAVASGGGVSQGTWTCSRCTYINTNSLKAVCEMCEGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYE8</accession>
    <name>A0A914AYE8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068727.1">
        <property type="nucleotide sequence ID" value="XM_038212799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212799.1">
        <property type="protein sequence ID" value="XP_038068727.1"/>
        <property type="gene ID" value="LOC119738072"/>
    </dbReference>
    <dbReference type="GeneID" id="119738072"/>
    <dbReference type="OMA" id="AIRWIYL"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="30"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="466" mass="50782" checksum="ABE3E5958EE9E1B5" modified="2023-02-22" version="1">MSSCIKSISMASRGSQHVHQHDHDKWGWVMVAVVFLSMVVIMGNLSALGVLLMPMTSDLDSELWLIGWIAVWSNVMKNCTGPVVGALSRLFGSRPVMIFGGILLGLGFILTSISHNIFATTFFIVGLTGLGSAFLFINSFVVLAPYFKERYPLAIGLSMMGTPIGVIVYAPVTQILLDTYGWRGTMLLLGGISFHLVAFGMLVRRDPSSSPSDTEQYQKVANSDREGESSQEEGSYPAGDETSTSEKRHHPSPDLHKSSARKYFRHFIRTIDFRVLADVRFILLAFGRFAVTFVYNAFVMYMVSHGQLSGLNHTQASFLPTAFGVGNVIGRLVAPFLQQVGAKLSVTFWACLGAALMSVSFLADALTGAFLWQLAVSGLIGVGYGTVVQAVDVMMRFLATDDRLVSVLGWLGLFKGVAGMLGALIAGLIFKWTGSFTITFYMYSGMMLLSIPLFIIEAVYGKSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0M0</accession>
    <name>A0A914B0M0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069453.1">
        <property type="nucleotide sequence ID" value="XM_038213525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0M0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213525.1">
        <property type="protein sequence ID" value="XP_038069453.1"/>
        <property type="gene ID" value="LOC119738617"/>
    </dbReference>
    <dbReference type="GeneID" id="119738617"/>
    <dbReference type="OMA" id="QAFCKTQ"/>
    <dbReference type="OrthoDB" id="10072259at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="918"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="976" mass="110134" checksum="68FC81E6953B6C2B" modified="2023-02-22" version="1">MFNNQLSAKELYSTNPSQFLQRSGFRTDPEDSAFSSSLSQNNSQVMSSQMDNSQSSSFDMFSQMMMSQQQGCSQQTENANNPQRFYMKYMSKAPLFSKEPDKNPLPRRKSFQEQLDSNKQKAKERDDRDLINTFINLVKECTEEVKSAASDIKKDVDKNISESACQFSSLIQKINEDLKHYHSTLLDAVKVREDKQATLEAMQQDLAAREAKIEVLETQLAAANKQREERVVESVLETYTEQQQKNREQMDKMQEEQQAFCKTQMDRLQQDQQRYLQRCEAEREAAKAAEPQTATGRRDGCGDQLAGVSLPPPVTETDYRPRSWQGLPHYEQSGCNTQMMRSYQDNPGFQNKMRPLQSNASIAQHNDVSIGTVLQPTSASFSNHGNRISLPSTSVAWPMPLENQNKELYLQSSNQCYQGHNPYNQSVVNPQARPAFPTGNSCGQENRPSGLNLQQGNQAPSVMSPPGTSNHQGPWNSNKLKPSPMAAVAPQVKPQEVVHPSREQSNQDDREETGSETPQAAVPKKRKGKKRYQVAVKTKKQPSRAKAKQKSISLERKINMENDQENQPIHGKHRRYIDEAGPTVDVRPTQAKKIHIQPKTNEDIYEYREEEGEKISNSKRKPQGKQTKRVQQASRHQVEEDVQRGSKDLPKQRGPGRQTKKVFNPAAKQPVHQSKLINHLPKATDQDASKCADTDKRAASSVAQKSRGKQKAKSSLTGASSEDGIFSQARVRTYSRGQDARISNAKSSLSHPKLQNQKPKRKRSMKEQKPDVISYGSSSEDEDSESQRPNGNLSQDLSSQDESNDDREEQTMAPVKIQRKTRKQANKKQTDKPVSCLVQPLVSQLDTMPSFSDQEDSSEEMIFSLKLPDSPCLQNSSLKQAKYPRQTEEQVVPIARSSDILSTPYIQLNNEQDSDNESVGTTYSVSVGSGRRLSRHMERKRRLSHYSGSSTSAAMVEITNSLRLQHRKIRRVSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1G1</accession>
    <name>A0A914B1G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein shisa-5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069629.1">
        <property type="nucleotide sequence ID" value="XM_038213701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213701.1">
        <property type="protein sequence ID" value="XP_038069629.1"/>
        <property type="gene ID" value="LOC119738752"/>
    </dbReference>
    <dbReference type="GeneID" id="119738752"/>
    <dbReference type="OMA" id="CILCCYY"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF23">
        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036780048" description="Protein shisa-5-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14457" checksum="F9E8E200A4ADF97E" modified="2023-02-22" version="1">MAESKHCGIVVWSLLLTLLYAANASQVDDTINDVVSLGVGVIIAIVVGCILFLVLCICCCYYCCCRSPPPAQQTVIVAQSAPAQSTVVVAQAPQAVYNPQPMGPPPMQPPVGYGQPQAGYDGPPPYPGQQTGYGYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B533</accession>
    <name>A0A914B533_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein 55</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070596.1">
        <property type="nucleotide sequence ID" value="XM_038214668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B533"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214668.1">
        <property type="protein sequence ID" value="XP_038070596.1"/>
        <property type="gene ID" value="LOC119739656"/>
    </dbReference>
    <dbReference type="GeneID" id="119739656"/>
    <dbReference type="OMA" id="HEHCLEN"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="85512" checksum="6C3B5F9D44CA4FEC" modified="2023-02-22" version="1">MFSPFGFLGPRSSMEFANTPRSHPSNRVEGTDHESECLEHDDGSHMMAHQAAATGNVPLLMEAVNHDPSALESQDEKGMTPLSRAVTSKQLDMVKLLVKMGADINTQDALGRTPLCLAAYEGWYHGVVYLLRSGGKQAIADRSGRLPLHAATYDKDSRSLSALLQTLTIGDVNEPDNDGMTALHWAAFHNRPEHVQLLMLRGGDLFSVDVDGKTPLHWASQNGCLACCSIMAKCRSGGAPLINMLEGSGKSCVHLAAAAGYSNILEEYVDVPAVDFESLDPDDRTPLHWAAASVQLECVEMLLQLGIDPSPHDVNGGTPLDYAKQAANQDIITILQRAGAQFGTMATASSRASQDADRTGEGDRREPWKKRFGFISEWFNRRKNGLRYKSSSEESDGPNGAQDRTVVAKVTPDHPNYAMGYNEPDCHCDHIAGSSEEDLSEEALHPTVTDTIRNEPHGNQDDLESTLGKRSLSEDLSYTRRNSFPASGGGGLTIDSLDKSPRRASDNILRATSPMLLDNIHSKGNSLDKHNLLPTVTSLTASGSPKSPGFMTDEGLCLGEVAIPLRPLCRDLPDADTVQRHAQEILDAQRSESWLSSGNNGNRKPIPSLCGRSLSQKNLYISNVPKLAPLTSRPPMSPGTGESTFSLPPQRTTSISPSLLLRSDTTSTSMPSHYLPLKQRSFSISSDTKYGSCPTINQKGLINRSSNLKSSRLEALQPIQPHGSAEKSEKKKKKKKPKPLTAGKLQESFDSTDLTRPASAEPTKTHHFSHTLSTPLETVTASAESTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5D3</accession>
    <name>A0A914B5D3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071293.1">
        <property type="nucleotide sequence ID" value="XM_038215365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215365.1">
        <property type="protein sequence ID" value="XP_038071293.1"/>
        <property type="gene ID" value="LOC119740155"/>
    </dbReference>
    <dbReference type="GeneID" id="119740155"/>
    <dbReference type="OMA" id="CNRNWTY"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037770790" description="SRCR domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="485" mass="52273" checksum="983F8AC7CA7DFCC8" modified="2023-02-22" version="1">MVLVLRADGLLKFLLMATSVGLARCVSFGTSASNLVGYLGGGAARNEGWLQLYVDNQWVTVCNRNWTYDSADYTCRRLGFDGVRPDGWGVHLGEGTGPSWCLDGGDQGDWELVPCPVDGDDVCTHSDDVGLSCVWDPEPDDFLNRLGYMFRLTGPAVGQGEGRVEVFYGSEWGTVCSRGWTQYFADAVCKHLGYREGVQDDGWMLPAQEQGSGPVVCAEIFSLGLCPAAGGVEAAGEACTHSHDVGVRCRQEGDEEDGINSGRDMELVRLGIVAASSVLVAGGLFLPLLACYLMVKSPARRLSEDLENLIQAKEEETPPEGDGLEEVGVATEGEVNEGYTEEDERAGDGSLREEVKGQASDADKHEEEINSTTGEAEEASGDPGFDESTSGCKETSAAVTVNDVDDIETIGDNDTMEPHESAEMTQNAVNQQDKEGISQAEESPTLPAEERPQDSHDYEVLNEASTPENYEFSMHGEHALDSVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5Q4</accession>
    <name>A0A914B5Q4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Organic solute transporter subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071420.1">
        <property type="nucleotide sequence ID" value="XM_038215492.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071421.1">
        <property type="nucleotide sequence ID" value="XM_038215493.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071423.1">
        <property type="nucleotide sequence ID" value="XM_038215495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5Q4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215492.1">
        <property type="protein sequence ID" value="XP_038071420.1"/>
        <property type="gene ID" value="LOC119740246"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215493.1">
        <property type="protein sequence ID" value="XP_038071421.1"/>
        <property type="gene ID" value="LOC119740246"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215495.1">
        <property type="protein sequence ID" value="XP_038071423.1"/>
        <property type="gene ID" value="LOC119740246"/>
    </dbReference>
    <dbReference type="GeneID" id="119740246"/>
    <dbReference type="OMA" id="IWISGAS"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40949" checksum="D9DBF2FC7E673124" modified="2023-02-22" version="1">MAATNSCAMGDLTSEELFEDIGKSAAAITAIVLLTATSILTLAMFIESVFSANKKIPNSRRRVRLIIMMGIYPTMSVTSMISLYVPAAHLLNTLVASVYFSVALFQFLMLIIDYYGGKAAVVEKLKDQRISLASPPLTCCCPCWMPKITMTPSNLRNLRRIVMQVAFIRPLLFFISLVLWTDGKYTHGNIAIDEPYIYITTFSALSGLLALYGIILFLTASLEPLRSFRIRPKFFIVQMVLILISTQNLILAILADVYVIPCVAPFSSDSRANYIGDMMIIVEMLFFSVLSRMYFRGRFGNIDLIDVNAPMGGRLTSYGPYAVVTSDQEKPSGPHDGKEVEVNGNAQFKVENEKSGDQTTKLEQGNATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5W8</accession>
    <name>A0A914B5W8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071210.1">
        <property type="nucleotide sequence ID" value="XM_038215282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215282.1">
        <property type="protein sequence ID" value="XP_038071210.1"/>
        <property type="gene ID" value="LOC119740080"/>
    </dbReference>
    <dbReference type="GeneID" id="119740080"/>
    <dbReference type="OMA" id="HREMSST"/>
    <dbReference type="OrthoDB" id="5983955at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="721"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="782" mass="87448" checksum="1E1730FF21F5DD6C" modified="2023-02-22" version="1">MNYQFTGGIISNKSIQSVCCLQLRWQIGVFEIQRSVGRMEAADRAASLLVFHRDRLNKLRNGISRVLDAFADVLDDKGGISGNEHAEVKKKLQEIEDTSWSRIREHFLDSHEPSDEPSDEPREGRNIARILLDFTDKLDDVKDALDDRLRELAQKKESKLQLDVKDLQKKLAEEKTKTADLRWKHQELAESSSSEKHFKGVLQQQLKEKQDIIAQLQRNGTVQLWEKEKAKLLEGSRQREENLTRELTQLRAAHEDMKDRLNRRIKDLEEKVRLERMKDIVSKLASKDEMEADVESLKRQLYTKEVDLARLDQELINQQRLIVGCIKGIQRDFRVMGERQEGRRLRKDDMQKMNLILDAILTGAKEARLDITKADLPLHYIALPEDIVAHPVKRMTRPSILAPVVNRHLETIGDSPSTSPTSSPPDSPSQPQRRVPSLELPHPSSSPALSSLGRASTVPLIETPPINGQASATGAANRRAPSGRAKISVDEVGLITKSPRGGSQKAPNPNTNTSARSPNPARKLRTTSVSESSRSPSLRRRAVSSPVPPDLAALVKPPASLSPRETSGSTLVPRQPSRSPSPGGRNGMASARKPRGSGKLQASNGNKDISKENDNPAQDSKPKPKSTLTGHGELNLEKGKQRGTPFSLNAAHFFRKDHPALIDKETGMLDAATARTCFPHISEEQIREHYQQFKKYDTNGDYSLDFMEMTQAIQSTVADYYKPRQIKEAMVEIDVDQSGSVDFYEYLGVSTMLMMKIGKSEIFRSSMVKHAGGSISKVCSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6Z5</accession>
    <name>A0A914B6Z5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071729.1">
        <property type="nucleotide sequence ID" value="XM_038215801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6Z5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215801.1">
        <property type="protein sequence ID" value="XP_038071729.1"/>
        <property type="gene ID" value="LOC119740474"/>
    </dbReference>
    <dbReference type="GeneID" id="119740474"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="295" mass="33511" checksum="1A826AE6049A8305" modified="2023-02-22" version="1">MNASDIITGARYALTGCAAVATVENLLVLVVFACTSRLRMKYYGFLINLTLADLFYAVMANAFTWGGPDYSDILFSIFISGYFVGIWTILAEGINRYLLVSFVDTARYDVLVTRNRLVAVCVLIWVVSVAVHILLAVLPDSDFESLFDGVIKPLTVFVFWLITAGLYIVVFRKIKAYYTTRLASSPPLQTSCRKDQVRTRVRQTRRLLVTFTLILITSFICWMPFSVMQVVSYLHRDLEYQNAVFWITGTVYCLAPIINPWIYWMLVPGFREGARQVFCNRESLPVDETVSETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7P1</accession>
    <name>A0A914B7P1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038071447.1">
        <property type="nucleotide sequence ID" value="XM_038215519.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215519.1">
        <property type="protein sequence ID" value="XP_038071447.1"/>
        <property type="gene ID" value="LOC119740259"/>
    </dbReference>
    <dbReference type="GeneID" id="119740259"/>
    <dbReference type="OMA" id="TSARWIQ"/>
    <dbReference type="OrthoDB" id="10067432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="736"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="905"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1323" mass="144228" checksum="53F7DF2FD3692B35" modified="2023-02-22" version="1">MYNYASAYAAAFSESYKKACDSNPMTAGGGQHYGTCGPYGSATIRGRCPHTARVNGSENPRGGDTRPRSRNAGQLMTGSRWVSPSGYVHRQIDSAKDERNLKPPLQGPQVRKACDSDPSARGSGQRYDNCGPRSATVQGLCPHSARVESGNPRGGDTRPRSRNAGQPMTGSQRMSQSGYVHRQIDSAKDERNLKPPLQGPQARRLSPLRRLPQRNKVRPLNIDGLLLTSEARPPCPSDSARSYAMFNASSQISNTTQRSGNLVVAGQSRKLANITSDRTSSSPPEDDIDRPPSVVVGQAFVPTTSRSKRTWKTRLRSLFAPRSRGTKTTVQPFVTPQGQSEGQVSRPRLLEEDHSDPGQVNRPRSLKEDHSDPGQVSRPRSLKEDHSDPGHQSHTSALMKNREAKEFGGDALTIKMHHRQCSAAMATRPASYSNQPLPIPGTPQFDWDRLQSSSHPAPRSDNLITSQKQKEVTGLVANYGDGSLPVSAPRNASFRNSSVCDLPSFPSQGQGAKMRDKISSDEEVTIPNADPLTSISRGDGKPHEEGRESGDHGCGWESISVPVSPSPSHQSVSSSSKNSSPSQNVGSETDVEDFIYNVDGESSSVSSMSDSSWAMPNSEADADVDSFDEETIADKSRQRFTELPPLRQQRLALKMAPAFALKTSYPEDFAHWLTVVLSCIERRDVMRRMQLASNYKTPFTRKEAWEIHANAAKAKDIMRQLNQIISLSTKDEESSIESLQLASPANPVKKDSEIEGDRRTSSATPQVPKDAWSSRQVASSKDSESSASITPKTKFETTLKEHKEKVEKSDSDQEEVTPAECPESSISKLSEMMSTESKPWDVVNKASPCAHLPTISKKSSSNDCASRAASHAQKDTLSLEKGAEYTSSMNAKKYIVYAQKEMDEIARKPEETEKSDSDRPSGSPASLLPKLSDKTPTSASSGVVVNKVSVEENYHSPQPKISKNSSWKDVATTDNTSSTANASSKNPQATQSPQEGLLELTAYPSIDPSELEFIMSDNGKEVALGSGSCGGVLLMRHKADNTLLAVKVLVKNFSFLQHEVAAMHAVRNCPFFPKFVGVIDYCSYAQELVGGVGRNTAYDFRKALHDDLLNALEWLHVCRDVTKGLKALHTAGWLHCDLHCGNAMVCPNPPGSDVAWRGKIIDLGNALQISNPGPVTILDDEQQKKLYELAKQCAPEILEGRDTFTEKSDIYSLGNLFVDVASDANIPHGLRLLGEFCMRRSSDARPTLDAISGKLDDFISEMMQAEQQPSSPSPIPPPSSSPSPNLRCHLIAEMVQAEQQPSSPSRIPPSPSSPSPKMRCRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B811</accession>
    <name>A0A914B811_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071955.1">
        <property type="nucleotide sequence ID" value="XM_038216027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B811"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216027.1">
        <property type="protein sequence ID" value="XP_038071955.1"/>
        <property type="gene ID" value="LOC119740656"/>
    </dbReference>
    <dbReference type="GeneID" id="119740656"/>
    <dbReference type="OMA" id="ACKRIVP"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903531">
        <property type="term" value="P:negative regulation of secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08388">
        <property type="entry name" value="C2A_Synaptotagmin-4-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000039">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000051">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="173"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="309"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49711" checksum="9AB993A83DBBAF0F" modified="2023-02-22" version="1">MSQYSCNQDIFDLQVRVVAMSTAALVGVCLAVITSVLLLVLSVYHCYRRRYKASFFHGGTAEKGNRTFYARPASKPISSPELSSPDSLHGKGMPTLGPSKTFPPGTLSPVSPLSHEKKALMKTYSASTGGVSGGMDPGTFNKDCYSEGGELKNESGWQGDNKLQGSSTEDLTHLGQITFTVEYRTDKGVFTVTIHQAQGLPVKDPQSGTSDPYIKLCLLPEKKHKVKTRVMRKTLEPVYEETFTFYGLAYNQLQGVTLHFVVMSFDRFSRDDVIGEVVVPLANIDLSEKAVTLTREVKPRHPKISKSQGRGELLTSLCYQPAANKLTVVVLKAKNLPKMDVTGLSDPYVKIYLMYNNGRLAKKKTRLKKRTLNPVFNESFLFDVPLEGLENVSLEFQVLDHDRVMKNEIIGRLVIGKEAGENEAQHWADIMRNPRKQMAEWHKLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA05</accession>
    <name>A0A914BA05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Deleted in malignant brain tumors 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072277.1">
        <property type="nucleotide sequence ID" value="XM_038216349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216349.1">
        <property type="protein sequence ID" value="XP_038072277.1"/>
        <property type="gene ID" value="LOC119740886"/>
    </dbReference>
    <dbReference type="GeneID" id="119740886"/>
    <dbReference type="OMA" id="ECSHSPW"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000026">
        <property type="entry name" value="Tequila, isoform D"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0768">Sushi</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="4029"/>
            <end position="4050"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="16">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="283"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="387"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="491"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="594"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="730"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="833"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="934"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="973"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1076"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1282"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1383"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1421"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1524"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1627"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1730"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1831"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1869"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="1972"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2075"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2178"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="2279"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2317"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2420"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2522"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2625"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="2726"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2765"/>
            <end position="2865"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2868"/>
            <end position="2969"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="2971"/>
            <end position="3072"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="3075"/>
            <end position="3175"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3175"/>
            <end position="3209"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="3213"/>
            <end position="3313"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="19">
        <location>
            <begin position="3316"/>
            <end position="3419"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3420"/>
            <end position="3482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3481"/>
            <end position="3517"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3514"/>
            <end position="3579"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3578"/>
            <end position="3611"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3614"/>
            <end position="3650"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3647"/>
            <end position="3714"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3713"/>
            <end position="3749"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3752"/>
            <end position="3813"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3812"/>
            <end position="3848"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3851"/>
            <end position="3912"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="3911"/>
            <end position="3947"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="20">
        <location>
            <begin position="3950"/>
            <end position="4013"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="516"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="529"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="755"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="768"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1204"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1248"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1321"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1446"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1459"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1594"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1652"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1665"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1696"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1800"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1855"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1894"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1907"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1938"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2042"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2100"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2113"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2144"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2248"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2303"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2342"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2355"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2386"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2489"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2547"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2560"/>
            <end position="2621"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2591"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2695"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2751"/>
            <end position="2760"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2790"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2803"/>
            <end position="2864"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2834"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2938"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2996"/>
            <end position="3060"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3040"/>
            <end position="3050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3100"/>
            <end position="3164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3113"/>
            <end position="3174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3144"/>
            <end position="3154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3199"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3238"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3251"/>
            <end position="3312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3282"/>
            <end position="3292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="3389"/>
            <end position="3399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3453"/>
            <end position="3480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3507"/>
            <end position="3516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3550"/>
            <end position="3577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3640"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3685"/>
            <end position="3712"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3739"/>
            <end position="3748"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3784"/>
            <end position="3811"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3838"/>
            <end position="3847"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="3883"/>
            <end position="3910"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="3937"/>
            <end position="3946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4086" mass="432201" checksum="4D048FEBF838ABE9" modified="2023-02-22" version="1">MGQALDDLVPLPFNGVVRPVSVDYDPREQMVYWTDISSQPSPKISRANIDGSNQTTIVDGLEVPDGLALDVVARMVYWTDDGLRHMGRTSMDGNGSKEIILESLDHPRAIIVDHDNGHIYWTDWGSTGKIERADLNGNNRIEIINNDLRWPNGIAKDGNYLYWCDAYLDKIERSDLSGNNRTLVVDLSRSGLIHPFDVAVYNNSVYWTDWHDHSVGHLLPNGTVGSIGPSVLAQAWGLHIEKANNSCDSSPCSSNATCVDVINGFSCLCPMGYDGPTCELAALRLVGNTTRSEGRLEIFLNGEWGTVCDNSWEQEDADVACRQLGFPAGANAATSGAMYGGGSGPIHVDNVTCTGQEDYLEHCQHVGNGVHNCTHDEDAGVWCSPSVRLVNGSSPNEGRVEVLWKGVWGTVCDDGWDVDDATVVCRQLGFVGARVEAFPAAAFGQGYGLPILLDDLRCVGDEDSVFECGHRGIGSHYCVHQEDAGVRCAELRLVGGRTHNEGRLEVLVAGVWGTVCDESWGVVDAGVACHQLGFPGVINATRGGAFGTGHGPIHFGNVTCSGQDTKLQDCQLSTGEALHCTHSQDAGMVCSPSVRLVGGLSSTEGRVEVFFRGAWGTVCGYSWGLIDASVVCKGLGFSRAVETPTFGRNYALDILLDNLDCDGDEWTLFDCRHNGPGIHRCTYYQDAGVRCDACSNDVCVNGGTCNTVANGISCHCPSGYSGPSCEFAGLRLVGGNVSSEGRLEVLLNGEWGTVCADSWGLEDAQVACRQLGFPGGMEATPGGSYGRGTGPIHLSGIMCSGQESNLENCTHSGIGIHNCTHANDAGIVCNPKVRLADGQSSNEGRVEVFWNGAWGTVCDNYWDIINANVVCRELGYSQAVQALRYAAFGQGDEFDILLDNVQCSGDEDTIFDCPHNGLGLHDCRHYEDAGVRCEPCDSDPCNNGGTCTSTLLGNITCLCPEGYSGRTCDYAELRLIGGRTPNEGRIEIFLNGTWGTLCDSSWGQEEARVACRQLGFPGVVEATTSQSYGNGSGPIHLDNIVCSSTDNSLESCQHSGVGVHACNHTMDVAVVCSPAVRLVDGSSSIEGRVEVFYDGAWRTVCDNGWDTSDATVVCRELGFGEATFAFSDAFFGSNYDLEILPHDLMCHGNEKTLFDCEHGGAASRYCSHYEDAGVRCANIRLEDGHIRNEGRIEVFLNGEWGTVCEDSWGLPDAQVACRQLGFPDAIEATQGGAFPSGMGPIHLAGLMCTSAESSLDRCPQGGMGVGNCTHFQDAGVICSTAVRLVGGSSSNEGRVEIFWDGIWGNICGDYVWSIIEAEVICKELGFSRAVRALSFGQSFGLVTLLSYVRCTGNEETIFACRHSDPGFDFCSIFGDGYAGVRCEPCDSRPCMNGGTCRSSSANFTCNCPAGFTGQTCAYAELRLVGGSHHYEGRLEISFNGTWGTVCGDLWGLEDAQVACRQLGFPGVIRASQGGSFGSGTGPIYLDDLICNGREINLESCGHAGIGIHNCNHTNDAGVTCQPAVRLVNGATLNEGRVEVYAGGEWGTICDDRWDLTNAAVVCRELGLGDALKALSRAVFGYGNGMPILLDNVACTGQEDTVLDCRHAGIGSHNCGHAEDAGVRCGRIRLADGNIENAGRVEVFVNSEWGTVCDDSWGLQDAQVACRQLGFPGAIEATQGGSFGSGSDPIHLVDVACTGSENNLESCPHGGIGVNNCTHSEDAGITCEPRVRLVDGSSSNEGRVEVFVNGSWGTICDDSWGLNDARVICHQLGYSSALRALTSGYFGGNYGLDILLDNVACTGIEETVLDCRHNGLGNHNCRHYEDAGVRCEPCDSRPCMNGGTCSSYPAGFTCRCASGYSGPTCEYAELRLVNGSARNEGRLEISFNGTWGTVCGDLWGLEDAQVACRQLGFPAVVQAAAGGSFGSGTGPIYLDDLMCNGQESNLESCPHSGIGVHNCNHANDAALVCDPAVRLVGGSTTNEGRVEVYSGGAWGTICDDGWDLRDAAVICRELGLGGAVGALTQAVFGQGSGLDILLDNVACSGDEETVFDCRHRGLGVHSCYHFEDAGVRCGKARLVGGDTHNEGRLEVFLNGEWGTVCEDSWGLDDALVACRQLGFPGAIEATQGGSFGSGSGPIHLDDVACTGTENNLESCPHGGIGVHNCTHNQDAGITCSPSVRLVDGESSNEGRVEVFVTGSWGTVCDDSWGLNDARVICRQLGYSSALQSFASAYFGGNYGLSILLDNVACTGNEETVLDCRHNGFGNHNCRHSEDAGVRCEPCDSGPCRNGGTCSSSSTGFTCSCPSGYGGPTCAFAELRLVNGSTRNEGRLEMSFNGTWGTVCGDLWGLEDARVACRQLGFPAVVQAAAGGSFGSGTGPIYLDDLMCNGQESNLESCTHSGIGVHNCNHTNDAGIICSPRVRLVDGSNTKEGRVEVYSNGWGTVCDDGWGLNDAAVICRELGFGEAVQALSNAAFGRGDGLPILLASLSCTGNEETVFDCPHLGIGVHYCGHYEDAGVRCENIRVVGGNVYSEGRLEIFIDGEWGTVCADSWGLEDAQVACRQLGFPGASEVTLGGSFGSGSGPIHFDDLACTGSETDLGSCQHAGIGIHNCSHDQDAGVKCTPRVRLVDGASSNEGRVEVFWNGAWGTVCNDYWGINDATVICRELGFSTARRAVTDGSFGGNYGLSIFLDNVQCTGNEETVFNCQHNGLGNHNCRHYEDAGVRCEPCDSRPCMNGGTCNSTSSGSYTCLCPVGFSGINCDSAALRLVNGSTRYEGRLEISFNGTWGTVCGDLWSLEDARVACRQLGFPDATEAARGGSFGSGTGPIYLDDLMCSGVENDLESCPHSGIGVHNCNHANDAGIICVPSVRLVGGSTTTEGRVEVYSGGAWGTICDDGWDLRDAAVVCRELGLGGAVGALTRAYFGQGSGLEILLDNVACVGDEETVFDCQHRGLGIHSCSHYEDAGVRCAELRLVGGNTRYEGRLQIFLNGEWGTICGNSWGLVEAGVACRQLGFPGALEATRGHGFGNATGPIHLQNVTCTGSENELNGCQYSWTGVNTCTNHSEDAGIICTPVVRLVDGSYPHEGRVEVFLNGAWGTVCDDYWGTNDANVVCRELGYSRALQALRNAFFGGGTGLILLDNVGCTGYEETILDCSHGGVGVHNCGHYEDAGVRCEPCGNNPCRNGGNCTSTSSGFTCQCSEGYTGTTCNIADARLADGRTYNEGRLEIFLNGEWGTVCDDSWGLDDAQVACRQLGFPNASMATRGGTYGSGMGPIHLRNVTCTGLEDSVESCPYSRDEMHRCNHTQDVGIVCSPSVRLRDGLTSAEGLVEVFIDGGWLSICSPAFLPGTGWDLSAANVVCRQLGFAGALHTLTMDGGYFFDVSLSRLHCEGDERSIFDCDFSVESSFCYPEEIAGVRCIVGCQLEAPEPSSVVMIASSNMTAYSPGDSVNYFCPDGYLLSGSATRICQSNLTWSGQPADCIQDPCGSGPCGNRGTCTSMPSGFTCLCPDGYEGPTCAEVAHCLLNISDILIVVSGQQAMYLPGDWVQFACPDGYHLLGSDRRVCQSDSTWSGLPTECSEDHCTNEPCVNGGTCTRTPSGFSCLCTVGFIGSNCDVDVCASGPCLNGGTCVGVTEGYTCQCPAGYDGSACENVTHCVVSLDPSDVLMVISQEQSVYLPGDLVEYSCPDGYHLDGSAIRICRSDLTWSGRPAQCVEENCGSLPCLNGGSCMSSPDGFTCNCSYGYEGRTCATVAQCLLRHNSSDVLMLLSGQQDVYTPGDSVQYACPVGYHLDGSAIRFCQSDFMWSGRPAQCIEENCDSGPCLVGGTCISSTDGFTCQCPDGYEGRTCGNVVHCVVSLDPSGVLVVVSDQQDIYLPGELVQFDCPDGYYLRGSANRICQTDFTWSGKPAECIADPCNSSPCSNGGNCTSNLGELTCRCPVGFGGSTCADETGCAPPSVSSNMTLGETHPWFKYGDEVTLTCDKGYEIEGSKDQAVKSVCRSNGTWSGQPVKCIPAESTKGPNAGISAPTIGGVVGGIILLILLVLIAAVLIKKWRGHQSGSPVFLGLQGDDVSLSTYSNPMFTKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAG3</accession>
    <name>A0A914BAG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cubilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073076.1">
        <property type="nucleotide sequence ID" value="XM_038217148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217148.1">
        <property type="protein sequence ID" value="XP_038073076.1"/>
        <property type="gene ID" value="LOC119741400"/>
    </dbReference>
    <dbReference type="GeneID" id="119741400"/>
    <dbReference type="OMA" id="RYMWVEF"/>
    <dbReference type="OrthoDB" id="6365689at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="296"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64228" checksum="3D4369F9B6B18291" modified="2023-02-22" version="1">MACSSGNRNRGERLKPVQSATRRRLWKCRFDRVAVEDEQMTTKTIQRHTEPNLIKLAANDSAIISSPSYPSNYQNNQDSQWVIQTAENFRILLSFKAFSTESCCDHLSVGDGMDSANYSTRIFRSSGSSLPPDTLSAGNAMWLRFTSDGGCVFNSCLNSGTCQPVGRSGFNCECLDGFEGTRCETELINLAANQSINITSPSYPNYYPNNLDIQWVIQTAEDFRILLSFKAFSTESCCDHLSVGDGMDSANYFKRIFMSSGNSLRPDTLSAGNAMWLRFTSDEGGTRSGFSLSARSYGSVELINLAANQSINITSPSYPSNYQNNLDIEWVIQTAEDFSIILSFYAFNTRYNDNVGVGNGLASTDSSTTVFRKSGNVLPPDTLSTGNAMWLTFTTDGYENNKGFSLSARSIGAIGCILNSCLNRGTCQPVGRSGFNCECLDGFAGTRCEAANQSINITSPSYPSNYPDILDIQWVIQTAEDQRIILSFHVFNTESCCGHLIAGDGIDWTNSSTMIILLPGRSFPSDTPSTGNVMWLRFISFGDLFGCVLNSCLNSGTCQPVRRSGFNCECLDGFAGTRCEAGKDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAQ0</accession>
    <name>A0A914BAQ0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073151.1">
        <property type="nucleotide sequence ID" value="XM_038217223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAQ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217223.1">
        <property type="protein sequence ID" value="XP_038073151.1"/>
        <property type="gene ID" value="LOC119741465"/>
    </dbReference>
    <dbReference type="GeneID" id="119741465"/>
    <dbReference type="OMA" id="DEIWISP"/>
    <dbReference type="OrthoDB" id="10580879at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="38490" checksum="8EFEF6D0522F10F7" modified="2023-02-22" version="1">MNDLREYYNDLNNRNSKMDVLQVAIQMFRLAVLLFVSIQCLTATSATTPIVSPRGICTSPDDFYQIKWRARTVDPGESLQVYCDRPDGAKIPMESVSSRLGDETTLTVHGLSDGRFSSCECAVMKDGTAVGAVQEMSKANIWVRNDTMFTISQDEIWISPDQEEFEVTFDVDCDFGGSFEVRYNNRLLEHRHSPGPDRLPYIKLRAGQPPVLCFPDPSCRDIGLYLIIYRASRNYKPIETARYLWIRANSSSCPTAVAIQENSTTGDVSMEKHQATKAFILNDVPKPDNGGTAGYFVIGGICLLLLAVCAYMLYQNRRLKMSLRESNQRNEQTTALNTVETIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBT2</accession>
    <name>A0A914BBT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VPS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073496.1">
        <property type="nucleotide sequence ID" value="XM_038217568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217568.1">
        <property type="protein sequence ID" value="XP_038073496.1"/>
        <property type="gene ID" value="LOC119741705"/>
    </dbReference>
    <dbReference type="GeneID" id="119741705"/>
    <dbReference type="OMA" id="HETYIAT"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VPS10" evidence="5">
        <location>
            <begin position="63"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="428" mass="47254" checksum="CF92CC30163DDCD9" modified="2023-02-22" version="1">MTLRSPGVLLVAKQGSCTYSASARVRVDGSWHGWYMFNDSNFNLAMIWTGTDGKELMALSTMEYTFFSEQSQLWISKDFGRSFVNINHRIRGAVIKAKDGVFKSSIDPQRVILVSYMEDQDMSQTRVYVTLNGGETFDESILPFYLDGAIVFHSTATNMLLAHSPYQQFKLWVSDDFGIHWRDVQSNVMSYSWGTKEMEPGALFVLVSSGTDKDKTGSGTRKLLRSTDYGKTFLAIKMNVYSFGVQGKFVFAAVDGGKGDNGRILYVSKDDGKTWSPTQLPVVTSDRFFSVLDMNEGMLFMHVDDEGDTGSGTLYTSDADGIVFSVSLKKHLFAEGSATTDFYRVASMRGVYMASQVGDDLSIHTNITFDRGGIWHPVKAPKGSKCKNSATSCSLQIHNRYSQIKGVNAPSSPLSQSSAVGLILAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC20</accession>
    <name>A0A914BC20_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi, nidogen and EGF-like domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072982.1">
        <property type="nucleotide sequence ID" value="XM_038217054.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217054.1">
        <property type="protein sequence ID" value="XP_038072982.1"/>
        <property type="gene ID" value="LOC119741303"/>
    </dbReference>
    <dbReference type="GeneID" id="119741303"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="289"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="544"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="748"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="1491"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="1774"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="2029"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="2233"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="2517"/>
            <end position="2681"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="2772"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="2976"/>
            <end position="3128"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="4">
        <location>
            <begin position="3259"/>
            <end position="3423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2124"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2869"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2124"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2869"/>
            <end position="2889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3483" mass="378421" checksum="D80C610140109758" modified="2023-02-22" version="1">MKEPLIAVFMTDISTGIVGALSFRQFSLRTPRNEMLFCEADETIREVFPSQSNFTTSLLLIVTWYRVPPYSYQTKENTFQAILATDGFRSFAVFNYEDIQWIHARMSTSSDFAQVGFDAADDSNFYTIPASFTEDTLYVHQDSNIGIRGRWVFRIDQPIVEIPGVNSSRNASEITKVCATPDGSQCLADGNPQGCTCLISPPQCSCSEGFFGLDCSSILFPFGFGDELVLNKDDGSSGEIPIPIEFPFFGRDFNSLYVNTNGLITFVEENTGYTPTRFPLAEDIPGLAVYWGDVDTGEYHPGSIMYRHRLRNSTRDAMLFLQADEIIRQVFPGLSDFSSTWMLVATWHKVAFHDADDNDDPAAILNTFQVVLLTNGVQSFAMLNYDNITWTTGGASGGNESGLGGDPAQVGFDASDGINYYEVPGSGSDDIVNIDGRSNINTTGRWLFRIDLHEIQGPVVIRCPTADAVNVTSGSGLGSVTWTPSRPVAVKISDNTPVPASCSIPNPSGGDDIIVTSDYLFPAGTTRVTCDAPTATCRFDVVVFDNEAPIFQSCESQIVWITPGVNESIVVWDSALFAVVDAVDGPVSASCSFVNGNLTRVPVGLNNTLPLGLTTVDCEASDAAGNNANCQFTVTLSASSVPTTDQTDSASEVTSTDGRISTTETTEFPTTANGMDVLFPFIGPDVIYVPSGDDETSGEVHISIPFPFLGRNYTSFYVNTNGVISFNDDLTSFPRNPIPLMKEPLIAVFMTDTSTEELGSLSFRQFSLRTPRNEMLFCEADETIREVFPNQSNFTTSLLLIVTWYRVPPYVYQTSKAVENTFQAILATDGFRSFAVFNYEDIQWIHGSRSSSSEFAQVGFDAADGSNFYTIPASFTEDTLYVHQDSNIGIRGRWVFRIDQPIVEIPGVNSSRNASEIAEVCATPDGSQCLADGNPQGCTCLISPPQCSCSEGFFGLDCSSILFPFGFGDKLVLNKDDGSSGEIPIPIEFPFFGRDFNSLYVNTNGLITFVEENTGFTFTRFPLAEDIPGLAVYWGDVDTGEYHPGSIMYRHRLRNSTRDAMLFLQADEIIRQVFPGLSDFSSTWMLVATWHKVAFHDADDNDDPAAILNTFQVVLLTNGVQSFAMLNYDNITWTTGGASGGNESGLGGDPAQVGFDASDGINYYEVPGSGSDDIVNIDGRSNINTTGRWLFRIDLHEIQGPVVIRCPTADAVNITSGSGLGSVTWTPSRPVAVKISDNTPVPASCSIPNPSGGDDIIVTSDYLFPAGTTRVTCDAPTATCRFDVVVFDNEVPIFQSCESQIVWITPGVNESIVVWDSALFAVVDAVDGPVSASCSFVNGNLTRVPVGLNNTLPLGLTTVDCEASDAAGNDANCQFTVTLSASSVPTTDQTDSASEVTSTDGRISTTETTEFPTTANGMDVLFPFIGPDVIYVPSGDDETSGEVHISIPFPFLGRNYTSFYVNTNGVISFNDDLTTFPRNPIPLMKEPLIAVFMTDISTEELGSLSLRQFSLRTPQNEMLFCEADETIREVFPSQCNFTTSLLLIVTWYRVPPYVYHTEGVENTFQAILATDGFRSFAVFNYEDIQWIHGSRSSSPEFAQVGFDAADDSNFYTIPASFTEDTLYVHQDSNIGIRGRWVFRIDQPIVEIPGVNSSRNASEIAEVCATPDGSQCLADGNPQGCTCLISPPQCSCSEGFFGLDCSSILFPFGFGDELVLNLDDDSSGEIPIPIEFPFFGRDFNSLYVNTNGLITFVEENTGYTPTRFPLAEDIPGLAVYWSDVDTGEYHPGSIMYRHLLRNSTRDAMLFLQADEIIRQVFPGLSDFSSTWMLVATWHKVAFHDADDNDDPAAILNTFQVVLLTNGVQSFAMLNYDNITWTTGGSSGGNESGLGGNPAQVGFDASDGINYYEVPGSGSDDIVNIDDRSNINTTGRWLFRIDLNEIQGPVVIRCPTADAVNVTSGSGLGSVTWTPSRPVAVKISDNTPVPASCSIPNPSGGDDIIVTSDYLFPAGTTRVTCDAPTATCRFDVVVFDNEAPIFQSCESQIVWITPGVNESIVVWDSALFAVVDAVDGPVPASCSFVNGNLTRVPVGLNNTLPLGLTTLHCEASDAAGNNANCQFTVTLSDSPVPTTDQTDSESEVTSTDGRISTTETTEFPTTSNGMDVLFPFIGPDVIYVPSGDDETSGEVHISIPFPFLGRNYTSFYVNTNGVISFNDDLTSFPRNPIPLMKEPLIAVFMTDTSTEELGSLSFRQFSLRTPRNEMLFCEADETIREVFPNQSNFTTSLLLIVTWYRVPPYVYQTSKAVENTFQAILATDGFRSFAVFNYEDIQWIHGSRSSSPEFAQVGFDAADDSNFYTIPASFTEDTLYVHQDSNIGIRGRWVFRIDQPIVEIPGVNSSRNASEIAEVCATPDGSQCLADGNPQGCTCLISPHQCSCSEGFFGLDCSSILFPFGFGDELVLNKDDGSSGEIPIPIEFPFFGRDFNSLYVNTNGLITFVEENTGFTFTRFPLAEDIPGLAVYWGDVDTGEYHPGSIMYRHLLRNSTRDAMLFLQADEIIRQVFPGLSDFSSTWMLVATWHKVAFHDADDNDDPAAILNTFQVVLLTNGVQSFAMLNYDNITWTTGGASGGNESGLGGDPAQVGFDASDGINYYEVPGSGSDDIVNIDGRSNINTTGRWLFRIDLHEIQGPVVIRCPTADAVNITSGSGLGSVTWTPSRPVAVKISDNTPVPASCSIPNPSGGDDIIVTSDYLFPAGTTRVTCDAPTATCRFDVVVFDNEAPIFQSCESQIVWITPGVNESIVVWDSALFAVVDAVDGPVPASCSFVNGNLTRVPVGLNNTLPLGLTTLHCEASDAAGNNANCQFTVTLSASSVPTTDQTDSASEVTSTDGRISTTETTEFPTTANGMDVLFPFIGPDVIYVPSGDDETSGEVHISIPFPFLGRNYTSFYVNTNGVISFNDDLTTFPRNPIPLMKEPLIAVFMTDISTEELGSLSLRQFSLRTPQNEMLFCEADETIREVFPSQCNFTTSLLLIVTWYRVPPYVYHTEGVENTFQAILATDGFRSFAVFNYEDIQWIHGSRSSSPEFAQVGFDAADGSNFYTIPASFTEDTLYVHQDSNIGIRGRWVFRIDQPIVEIPGVNSSRNASEIAEVCATPDGSQCLADGNPQGCTCLISPPQCSCSEGFFGLDCSSILFPFGFGDELVLNLDDDSSGEIPIPIEFPFFGRDFNSLYVNTNGLITFVEENTGYTPTRFPLAEDIPGLAVYWSDVDTGEYHPGSIMYRHLLRNSTRDAMLFLQADEIIRQVFPGLSDFSSTWMLVATWHKVAFHDADDNDDPAAILNTFQVVLLTNGVQSFAMLNYDNITWTTGGSSGGNESGLGGNPAQVGFDASDGINYYEVPGSGSDDIVNIDDRSNINTTGRWLFRIDLNEIQGPVVIRCPTADAVNVTSGSGLGSVTWTPSRPVAVKISDNTPVPASCSIPNPSGGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDE0</accession>
    <name>A0A914BDE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074074.1">
        <property type="nucleotide sequence ID" value="XM_038218146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218146.1">
        <property type="protein sequence ID" value="XP_038074074.1"/>
        <property type="gene ID" value="LOC119742111"/>
    </dbReference>
    <dbReference type="GeneID" id="119742111"/>
    <dbReference type="OMA" id="NYSEHQE"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF71">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="50591" checksum="54440413D5CC613E" modified="2023-02-22" version="1">MSRRYLFFLVTISAACFLLYLVVRHAPILGSHQSHIVSAVKLRSGQSSDVGLPSFSLCNCSCSTVNSVTRAAKGRHATTPASGHQTVVDVNSDPVRHDVVMGTRPLGSSVVIMAVMRTGSSFVGEIFGQNENTFYLFEPGIPLENELIAHNETSVFMQQLYIDMMNSLYRCNVTYLDFYLKSLSGKNQNTILKSAPRLFDSLCPKMKRGGSGRFLCGKVSPIQFVQKCREKRSIVIKSIRIWHIGMFLPLIQSANLKVIHLVRDPRGMTASRVPAMNVVDNTSNKLQAESFTEEMREYLIRYCSLSLENKETGLYLPKYRDNYFLLRYEDMSLDPERVTQLLYNFTGLGAVPETVSKWIAENTQAYRPGVYSTTRVSSQVYQSWRKKLDFKTAKAIENVGRCAEMMEHFGYLPVRDKSHLKNLSFPLLAPIPAEHDSQKYQSYRFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDR8</accession>
    <name>A0A914BDR8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073995.1">
        <property type="nucleotide sequence ID" value="XM_038218067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDR8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218067.1">
        <property type="protein sequence ID" value="XP_038073995.1"/>
        <property type="gene ID" value="LOC119742051"/>
    </dbReference>
    <dbReference type="GeneID" id="119742051"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="73"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="41445" checksum="2F86BD00D57C13D6" modified="2023-02-22" version="1">MLSHKVSESMFWLRDDRLAALVSSHFRLNHHDEVCFRICPVDEVVCRQSTMGSTLITVINYSGAVILVLAVLENLLVMVVLAATSHLRIKYFAFVFSLALADLAFSVMAIVYALNRARFLSALLQSSFFVSVLMILAVAVNRYLALTITPPSRYDALVTRCRLVVVCLLLWCFSLALHLPVVLVASDEVRLILSAWSRSMLVLAVWIVTAVLYRFVFRKIKSYVPPLASSPGLSIPDDSEQAATRVRQTRRLLVTFSIILVTSFICWIPFNVGQIMEYFIKTGQSTISDDTFNNYNWVCGFIYCLSPAINPLIYWWRLDGFRQGFKELFCRCLLQNQEQLVETVDGNENQQNTESTHWIKNDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEH4</accession>
    <name>A0A914BEH4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074638.1">
        <property type="nucleotide sequence ID" value="XM_038218710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEH4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218710.1">
        <property type="protein sequence ID" value="XP_038074638.1"/>
        <property type="gene ID" value="LOC119742597"/>
    </dbReference>
    <dbReference type="GeneID" id="119742597"/>
    <dbReference type="OMA" id="HSMCAQL"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000015">
        <property type="entry name" value="Hypoxia-inducible factor 1-alpha isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014887">
        <property type="entry name" value="HIF-1_CTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08778">
        <property type="entry name" value="HIF-1a_CTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="851" mass="94303" checksum="56E3D6B1FECC22D5" modified="2023-02-22" version="1">MHRPSSNSTSPPKEKKRRNSEKRKLKSRNAARTRRENETAIFYELAHQLPMPHSMCAQLDKAGIMRLLLSYLRIQHFTPKAIKSEPVDVDEDLPLTAEQLIDNYYLKALDGFAMMLSQEGDVIFISENVSHYMGLKQIDLIGQSIYDFSHPCDHEEIREHLADHHWMGQANGSKTVKRQQREKHRFLMRMKCTLTAKGKIVTLKAATYKVVDCNGIWKAAPSMMTSNGYPLPQLSCLSLIAMPIHHPANIEIPMDKQTFLSRHSMDMKFTYCDDRIQELLGYDPDDLANQSFYDFYHALDSHTIDRFHKDLFAKGQATSGRYRFLAKKSGFAWMETQATVIYNNKTNKPQCVVCVNYMISGVENEDVMLSTHQVDEAMQMSTEKTFMPRPDGMDDDEFPLYLTGSKSSVMNPEDLTYLAPTPGSAMVPLDFPSPPASIPETDLMQEPEPLDGQQEFTPFFSFIPLAPGNKEKQSKDGGVMMNQDSSLRNVATPDLILPDKNSPMSSSKDPLLLDCTAEAGGQLDDLAMRAPYISMSDDFDFSGDKLMVDTQLPETWEPVDLFGNNLNSTACMDSMISPSFKDQQPELLSPSSGSLTSVGNPYSPQSLSPYSPQSVGSPITPVNKLCQSLPNLWLCRDDDLVGPTPPQQQKQQGYWETNKSPLAASPPTRSPLISPALPGKHPPRPEVQQALKRKLETRNGSLYSKMARLNEGGRDSGGGNNPGGVELDALQPPGGGKERSTLQSLLFQPGGRSINNPFGHSLLLQKVAQQVVNKRGGGVNNAGLLATISSGKQELFPKFQTQPSPGEDAEDLLAGGYLPLIARYDLDVNTPLQASAGLLQGEELLRALDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEJ8</accession>
    <name>A0A914BEJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074663.1">
        <property type="nucleotide sequence ID" value="XM_038218735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218735.1">
        <property type="protein sequence ID" value="XP_038074663.1"/>
        <property type="gene ID" value="LOC119742612"/>
    </dbReference>
    <dbReference type="GeneID" id="119742612"/>
    <dbReference type="OMA" id="HYFCETH"/>
    <dbReference type="OrthoDB" id="9986014at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24020" checksum="A56BCD3B32D5A15D" modified="2023-02-22" version="1">MGAKSTKMGHVMGKLTDFLHVDCRFSMSGDRESRILILGLDAAGKTTILYRVKLGEAVTTIPTIGFNVETVTPVPNVTLCVWDVGGQQKVRALWQHYFCETHGLIFVVDSADRGRLWEARDELFRVVSNPHMTKGIPVLVLANKQDLPGAYSAARVSEVMDLQTLSENHPWQVIETQASTGDGLQEAFKIMARMVKQFHKDSSKADIASSKSGDATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEU6</accession>
    <name>A0A914BEU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074594.1">
        <property type="nucleotide sequence ID" value="XM_038218666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218666.1">
        <property type="protein sequence ID" value="XP_038074594.1"/>
        <property type="gene ID" value="LOC119742577"/>
    </dbReference>
    <dbReference type="GeneID" id="119742577"/>
    <dbReference type="OMA" id="FICVEKY"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF30">
        <property type="entry name" value="EXO-ALPHA-SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="482" mass="54534" checksum="616E6EBC20C3B65F" modified="2023-02-22" version="1">MLSRQIRMTLKRIAYSVRPSCQLVLIVLGVLTVVWVLILLQRPLEDMASTKNKRIEVPRPKEYATKKAYETDIEIVYKQGFLGYNTSRIPALVYHQGYFLAFCEARKETFRDIGSMDLVVRRGRRLDWKVQWGEVIVVVTKPGYRVMNPCPIVDKDLEAIVLVFIAIPAHLSQWTMVEDGFIQQQVMVTRSFDNGLTWTYPRDITASTLGKMRIPPGIYAPGPGHGIQTSSGKLVIPGNYFVKDKFGSMLKFEENIYDNANYANVIYSSDGGVSWHLGGSIPYGTDASGWTIHSNEAMVVEMQEGVLMLNTRTLHPDLPRVQSWSRNEGHSFSSGKLVPELIEPGYKLVNNETQSSKAAGCQASLIGFPAPHHISKHKTWLAFSNPASMFREHMSVRLSRDGGRTYTNPWTIYDLPAAYSDLTYFETLDRETGLKLQNFAILFEGGMDTPYEKIMFKMFNLDALLSRVPRTIRRHRTAAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFF3</accession>
    <name>A0A914BFF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074661.1">
        <property type="nucleotide sequence ID" value="XM_038218733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218733.1">
        <property type="protein sequence ID" value="XP_038074661.1"/>
        <property type="gene ID" value="LOC119742614"/>
    </dbReference>
    <dbReference type="GeneID" id="119742614"/>
    <dbReference type="OMA" id="NTCNDRV"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000005">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="93" mass="11022" checksum="607092FD3F91925C" modified="2023-02-22" version="1">MAIDDERLFENDPPEEEEEEEEEDEEDIVDPRDEILENCREDSHCAGFKQELEVCQERVTSRSNTEETCTQELFDFLHCVDHCASEKIFKHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG35</accession>
    <name>A0A914BG35_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074866.1">
        <property type="nucleotide sequence ID" value="XM_038218938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG35"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218938.1">
        <property type="protein sequence ID" value="XP_038074866.1"/>
        <property type="gene ID" value="LOC119742768"/>
    </dbReference>
    <dbReference type="GeneID" id="119742768"/>
    <dbReference type="OMA" id="TIECNDI"/>
    <dbReference type="OrthoDB" id="10066651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF4">
        <property type="entry name" value="DNA ADENINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26696" checksum="B964B6755DD37C37" modified="2023-02-22" version="1">MGAQFGWSTLSPTDNSIVKMALQGFKRQNSSPTIRKDPITPDILTKLHINHGHSSATLADLRILFVCFISYAGFLRFDDIRNISRNDCTISSDRLTIHLCKSKSDQFRQGTDVVIARTFKPTCPVLVAERYFSALGDPNNSTLPVLRRFVATKKGLTSSTKPLSYTRTREIVLDALRTIVPDVATYGLHSLRSGGASAAFNANVPPFLISKQGRWKTESASNVYFQLDKSSNLLATRNLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG51</accession>
    <name>A0A914BG51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074881.1">
        <property type="nucleotide sequence ID" value="XM_038218953.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218953.1">
        <property type="protein sequence ID" value="XP_038074881.1"/>
        <property type="gene ID" value="LOC119742780"/>
    </dbReference>
    <dbReference type="GeneID" id="119742780"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1894" mass="216949" checksum="0ECF78E6683ABB28" modified="2023-02-22" version="1">MDAKDSVSQISPMSNRTSSSVHVKAAAKRAELLCRQRLLTKKQELESRHLAVQQARQQEEFRLQRERENFDLQVEIEVSEASISAIEQYEDEFDQKIRFKLPDEIPHPAACASSVLGDRIEAGASEKVSSNEEPNKIENPWSIPQDFQVKVDEVENRMPELTPQVNIGQLHKDCAQLDHHVPEPTTAQRYQPHLQPISDIGELTQLLIKQQVRAALPAQQIETFNGDTLKYTRFIKSFEFGVEDKTTDGRDRLNYLCQYTSGEPNTLVSSCLHYHDAEEGYSKAKELLAKRYGNSHKIAQAVLNKANNWPDIRAEDATGLNKFSIFLSECKNMTSSVSALSELNHTQSIQMLVEKLPYRLRSMWRNKVYEVEEEKKRCIVLDDLVSFVDRHSQILSNPTFGRLREIPHLGKNNIGEKNKRVQVKKEAFGTAVNSHAEKARQKKSCQFCGSNSHHATLECMKFAQLSWKDKSSFCFKHGLCFGCLGVGHTKSSCKQRELSKCSKCPGNHPTVLHNDEKITKTSHPAQNSQTQVTTGCAGVLGAGANLHASGSPRMAIVPVLVKASSSHECIATYAFLDNGCGAVFADSEICRALKVRTRKRSIILKTLNSEEVVNSAIVIDRLQLGGMIEENSFIDLPDVYVKNDIPVSPEDMVTKDDLQEWTHLSHIQLPQLCSPAIPRVTLIIGMNVPAATTPIEVIRGDSGDPYGVKTPVGWVIYGVPGRPKSQLDANYINVLDGLTNLENQYKHYMNLDFNERLGESQDESALSREDMRFLDIVKETTEFQGGHYQMALPLQRPTVRMPDNRSLAEKRAVQLKRKFDKNQEFKEKYVQAMEDTIGKGYVEKVPDSQKFRSDGKVWFIPHHGVYQVQKQKMRVVYDCAAEYGGVSLNRQLLQGPDMTNGLTGVLMRFRQEPVAVKADIEAMFYQVRVRSEDRDLLRFLWWPGGDLSRELEEYRMTVHVFGAASSPSCANYALRRTATDNEQRYRSEVTNAVRKNFYVDDFCKSVPDKEEAKVISREVTDLLAEGGFRLTKWVSNQREVLRSIPREEWSKEVKGLQIDQDVLPPEKTLGVLWCMEGDTFGFEINVKDREPTRRGILSIVSSVYDPLGMVSAAIMPAKLLLQDLCRLKLNWDEKIPQEHLHKWNLWLMDLPKLECISVDRCFKPEGFQDPVSVQIHHFADASEKGYGVVSYLRLQNRYGDVHCSFVTSKSRVTPLKQQSIPRLELTASTVAVRVHNSIVRELEIPVDQTFFWTDSMTVIKYICNETTRFKSFVANRLTVIRDSSHPCQWKYVRSEQNPADDCSRGLPIDKFIANRRWFRGPEFRWHAEADWPSTCVTEEPEVDRDPEVKRVMAAVPIENLLSRSNAVKKLIEYYSDWNRLRRAAAWWLRLKRILRKRSKEEFKHDAVNNLTVEEIEEAEVSILRWVQHEAFPHQIKRLQEMNDGPQDLTRESPKQQKVDKLLDQLDPVMHKSLMRVGGRLQAAQLPEEAKHQIILPQRCHVTDLIMQHTHQKIHHQGRNHVLAQLRRRYWILKAGVVLKSVLKRCVICKKVQAKLGQQKMANLPANRLLSEKPAFTSTGIDYFGPFNIKQGRNIKKRYGVVFTCSTSRAVHIEIAESLDTSSCINAVRRFIARRGNIKELISDNGTNFVGPHAELKKAMSEWNHETLEKFATDRGITWKFNPPAASHFGGIWERQIRTIRKILQAMLNEQHMRVCRDEEQLRTLMCEVEYTINSRPLTHASDDPKDLNAITPNDLLLLRPSSLYVAPPGVFSEKDQYAKRRWRQMQFLADLFWKRWSREYLMDLQRRQKWLYPQRNLHPGDVVLVADNQAPRSSWPLGIVEKTYPDKNGLIRSAEVKTRTALLVRPVTKLCLLLEQETSVLKDHNEPLCNAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG85</accession>
    <name>A0A914BG85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylyl cyclase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074916.1">
        <property type="nucleotide sequence ID" value="XM_038218988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218988.1">
        <property type="protein sequence ID" value="XP_038074916.1"/>
        <property type="gene ID" value="LOC119742809"/>
    </dbReference>
    <dbReference type="GeneID" id="119742809"/>
    <dbReference type="OMA" id="VQDIQKH"/>
    <dbReference type="OrthoDB" id="206796at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27137" checksum="3CBE21598EC52015" modified="2023-02-22" version="1">MGDKAGGHDVPQDGICLKIQHIHQGEDWDCGLACAKMILRFLHPEFEDGPASFDDICERLGFGESIWTVDLAHLMVQYNVKHQLYTITLGVDPTYQEVAFYNEAIKTEFTTEQERVNDLFASAASKGIQVEKRSVTNAEIVSHVSGHNPAIVLVDNTILQCERCKPSQKHGEGCADCFSFCDTGRGGGYVGHFIVLCGLDLTKNHFLYRNPGILEELCCCSFTNLDEARRSHGTDEDILFIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH90</accession>
    <name>A0A914BH90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075251.1">
        <property type="nucleotide sequence ID" value="XM_038219323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219323.1">
        <property type="protein sequence ID" value="XP_038075251.1"/>
        <property type="gene ID" value="LOC119743015"/>
    </dbReference>
    <dbReference type="GeneID" id="119743015"/>
    <dbReference type="OMA" id="IYRSSWV"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="122"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="680" mass="75850" checksum="709DD0737C077AE8" modified="2023-02-22" version="1">MEGTANPSYSPEPDRYSAALSASPTSPRPRQRIPRSLSNRTGDAPDGIIYRSSWVGMNEDAVKVRSGHVFWRVFRLTSMGVIVAWWLAMFIAGIVVLARGDAGQGSLCLTQERWFDTAIGYQIVPASFQDSDGDGYGDIKGIISRLDYLEYLGVDAIWLGSIFQSAHADLWRDVTDLTAVDEVFGTIQDFENLVKAVHDKGMKLILEFIPNHSSDQHPWFQESRQGTDNEFRDYYIWADGTNGGPPPSTGSNDNDGQWSWEYDSTRRQWYLYSFMTEEPDLNYRNPAVIGVIQDALRFWLEKGVDGFYMRHVDRLMEPRMVTDSPADTEQGDGATSTVESINSESRQETLDVIAGWRHLLDEYEASNDTHDNSKLLAIDTGKDLALATLVYSNKSGDLGHAAASLPINSMLLDMASPLNGHEIRKAIESWMTAGPVGSSRLWTVGSADESRSASRYGEPFSRAMLFLVLMLPGSPLIYYGDEMGMTDAQKMNGSAAGMIRHDGELTRSPMQWSPDVYAGFTDASAAEPWTPVGLNATKTNVELQRRDNNSTLAFIERTIQFRINKSEFFGIDHPESFRLQTTFNEVLAVTKELPPESDFEASTQALFAAVNIAKYEVTEDFESRRERIPSTGIVVVATDASRIGESINFAKLLLRSGEAILIQYELLPKPDGFREPNEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHD7</accession>
    <name>A0A914BHD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074847.1">
        <property type="nucleotide sequence ID" value="XM_038218919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218919.1">
        <property type="protein sequence ID" value="XP_038074847.1"/>
        <property type="gene ID" value="LOC119742746"/>
    </dbReference>
    <dbReference type="GeneID" id="119742746"/>
    <dbReference type="CTD" id="5890"/>
    <dbReference type="OMA" id="IHCQGHN"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030548">
        <property type="entry name" value="RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46456:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="79"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="28534" checksum="8E6782851640C6B5" modified="2023-02-22" version="1">MALRKIQRLGIEPPIVERLNKHGIFTCQDLLSKTKLELLRMTGMTDSRLTAILLVASRACVPRQTTALCMYDRAGSEELPAFFRTSLTQLDHVLHGGLPVGTISEIAGPPGCGKTQFCIMLSVLATLPVAMGGLDGAVAYIDTESAFSAERLVEVARCRFPNHFSQDEAFVALTSRVHVYLESTCRSLLARLQNFEEDLITKGIRLVILDSVASLVRKEFDSSLQGNMVERTNLLSKQAAILKYLAESFSIPTFQNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJF5</accession>
    <name>A0A914BJF5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075956.1">
        <property type="nucleotide sequence ID" value="XM_038220028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220028.1">
        <property type="protein sequence ID" value="XP_038075956.1"/>
        <property type="gene ID" value="LOC119743616"/>
    </dbReference>
    <dbReference type="GeneID" id="119743616"/>
    <dbReference type="OrthoDB" id="5310573at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="126" mass="14278" checksum="73764B1BE9C190E2" modified="2023-02-22" version="1">MILNKTADGTGINSNILALQMKTNPELRDKLHDVTSWGPLPVYPGVANSELPEEVRYLSSRRLRSTVSDWTILDLDPKPHAYQGRLLLPTLHKTMHAIDVSTCRLQFLILSIAYLVWEIKINKGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJJ5</accession>
    <name>A0A914BJJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075991.1">
        <property type="nucleotide sequence ID" value="XM_038220063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220063.1">
        <property type="protein sequence ID" value="XP_038075991.1"/>
        <property type="gene ID" value="LOC119743877"/>
    </dbReference>
    <dbReference type="GeneID" id="119743877"/>
    <dbReference type="OMA" id="ARTFLIM"/>
    <dbReference type="OrthoDB" id="5967704at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="39269" checksum="420DF8554240DC7C" modified="2023-02-22" version="1">MAFQTTTDGGMTTMSPHNVTVVSVVKACLLAVTTTLILLGNSLCLIVLRYTRDGVSPVTKLFLISLTISDLLVGVLVGVPVVGSTALQSWPYGDAYCTVMAMCHVLYFNAGMSVLAINIERYIAVIWPLKYPLIVTMARAAIVEVFIIFILLLWLLLYVLMPDRMSFYYNNFSQCFIDSLNGTDYLGHIAMTLFIALPLLITIVLHVRLFVLATHHASKVGNITLGSFKLRDSESSAGQSDQPHPDQNAQPAAARPRTRRSPEAKAARTFFIMAVVLTISWTPYYATITWENLRSDPVPEALAFTSQLLLLLNSIWNVIIYYTRNDAFRKTANRLLGCCFRVHSWNDQELMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJS2</accession>
    <name>A0A914BJS2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076165.1">
        <property type="nucleotide sequence ID" value="XM_038220237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220237.1">
        <property type="protein sequence ID" value="XP_038076165.1"/>
        <property type="gene ID" value="LOC119744354"/>
    </dbReference>
    <dbReference type="GeneID" id="119744354"/>
    <dbReference type="OMA" id="FANEPHF"/>
    <dbReference type="OrthoDB" id="5870811at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42906" checksum="54E68E22FE149C99" modified="2023-02-22" version="1">MIMTMAHQDINMPIYWIMLTAVIVGTSVAIDHWPDSLYDGYDMVGSTCVVSYTSTEYISSSRGALVYSMIGSQYSVGTCYYIFYTADDGRLLVDAEKMGLDGTGACLNFEESSDSSFNRRRQLARYCGNTLFQVNTTKRYLKIKFDSSSYTDKAEFRLVVSPFFEGGVSIETFNCDDGYNISKDMRSDGHQNCPDNSDEKGASALPCSSRMLSCGESGPCIAKDWKCDRIPDCPNASDEEGCIYKCPGSSSNGESYQLECQDKSGCFSQYERCRGNSYSECDDGSANKYCDACDGYNDYYYFANEPHFDSYCPMTRTCMTAEQFCDGTTDCPNGADEEYNLCHPSIYWYWTGGQLAGLFIGFIIFTVVVVVVVAVVHKKCRKQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKP3</accession>
    <name>A0A914BKP3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076679.1">
        <property type="nucleotide sequence ID" value="XM_038220751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKP3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220751.1">
        <property type="protein sequence ID" value="XP_038076679.1"/>
        <property type="gene ID" value="LOC119744685"/>
    </dbReference>
    <dbReference type="GeneID" id="119744685"/>
    <dbReference type="OMA" id="CCKNESK"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="938"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="12">
        <location>
            <begin position="112"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="13">
        <location>
            <begin position="455"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="13">
        <location>
            <begin position="560"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="815"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="735"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1239" mass="141096" checksum="28D1CB474037D798" modified="2023-02-22" version="1">MAGCCSCCKPGQHQSYIATAEGPDHTDPSQVQVNFDTNNDAVTSQVQKKSHGGFRAQLTRLGTKNPESIELGGIGYMRQSSRYDLGFTKDYLSGSIKFSHSHKDHLKYTKSKYMAIQPDEDPDVVVAALAKKWNLEFPKLLISILGGGEEVVHVNQAMKKAFCKGLVEAVLSTDVWLFTGGLNCGMMKTVGQALTNYAIGRAMVKHRDVVAVGVAPLCILSQKDKLLGSERRPVKYNMDQDSDDSADEDDNATDHDSRDDASSPSYHLDPNHTHFILVGDVHSKPGDELTMRNALVHNIARCKIKGSNATVPVLHVVFGGDYSVFQTIHDAVTKHQIPVLVIPDTGGAADVLTFAINKRAEAGEENIAFDVKITHEIRMKLGLDPKCFVKTKDLIKGIIKRRHLINVYNQDVRIDEAILRALMNANRGCKGQDDLHLAVIWNRIDLAKKELLAHRKWKASELRDSLYYALVNNQPKFVKLFIAEGNIDLKKFLSTEMLVDLYNETKDESSVLYSLLDKQRVKRDYRGGYRFSLTDVSNVLKELIFDTYDYSTSHFYDGKACFNEPLHELFIWAVLLHRFRLAKLFWKRGKPSIGGALLASTILKALSELQRLDSQESAEMHTHAKMFQKMAIDFLNLCYVDDRHRTSLLLVRNLPDWGNSTCLDLAAAARSKQFIAHAAVQNLLNELWMGRLSRRTSVFKIWSCICFPIAVPFAITFMSKDDPTVPAKKMLEHQLSDGDAGNNESREDISSPLKSSKTTKDSYQTSPVEETDDCMSVKTYMTHATHRQHRNNGYSWWYKLKLFHEAPVISFRINMIAHFVFLGLFSYILLSNFTEKISVYEMVLIGWVFTLFTEEVRQIFQEDYHTLYHRFDAWLWGYWNCVDLLSLVMFAVGLGLRFHPVTLDAARIVLALDLIVFYLRILHIFSASQLLGPKLIMIVRMLVILVAFLAILMVFMIAFGVACQAILFPNSQNLASIIKGVFYQSYFQLYGELFLEDIDGVDCAVENADSSMQRCPQHSWFGTIVLAFYLFTSNILLLNLLIAMLNYTFQAIQDNTDTFWKFQRYQLVKEYYQRPSVVPPLIIVVHVYQMVRWAWDKCFPGHKLYRSLNLMKRELRQDKQIEISTWEEVKGEDYLAEMKRQAHQESNKRIKQTDERLEALSSKMTIYFQGGKLNKAMEGRFNIMEAQIANVERLVKSLSGAGMSLDTSDSAHQSSSHLQVLRHHPESYPLKRSKSATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM83</accession>
    <name>A0A914BM83_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076866.1">
        <property type="nucleotide sequence ID" value="XM_038220938.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220938.1">
        <property type="protein sequence ID" value="XP_038076866.1"/>
        <property type="gene ID" value="LOC119744801"/>
    </dbReference>
    <dbReference type="GeneID" id="119744801"/>
    <dbReference type="OMA" id="EYHAHAR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1129"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1233"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="306"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="706"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1003"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1321"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1557" mass="173664" checksum="596A65309D626ABA" modified="2023-02-22" version="1">MYEEWEWFCGNNNTYLSTDLSSEWVGNTCFINGLALLPHVAFIFFFALALFELGCVCNNRKRGKTKYVLCYPGHTVRWLVSLASLLVLAAAIGEGVLTDETYRAWQQSTQPHYYAPSAAAFIAMVLSLVYYHHMELWQIPSMSILLLIYWVLALIGESLQLADLKHHDIVDVTVLRFDLTVLMVIAYGILLLNELNLIRIKVVGTSKLKTINEDLQNPNMHFMDDYVSLLSKATFWWMNWVFAKGYKKPLEHKDLGDIPERHRAHHNHKLFQEAFDRELDRAERKDTKPSMFRIYIDAYGTVLLEGALYKMIADVLNIIGPLCIGAITGFVAKVTISADTKPPAPHYVEFGEFFANGYVLIVTLFLVVILKASFQNMHFKVVFVVGANVRAALQSVVYKKALRLATFTTSGGQMSMGQVTNHMSADATNVQVMFQFINFMWSAPFTIIIILIFLYFEIGFSALLGASLFLVAVPIQFRVAAILANRQKLILGCSDQRLKLTNELLQGIKLLKMYAWEELYCKQIEAVRKKEVRHLLYISLCMITSVSITFGVPILVTLVAFVTFEPLYGTPLTPEITFSSLSFFNLIAIPLFQIPLSVSTVVGSIVSSKRILNFLLAPEVEGNRGKLKEHGETQENNHSKDQKKYNDASRVVFHQLVTDDLEPTISIGIQTDDTDEETGPITNGISLTESTSSPVPSSPNTDRLAIKITDGNFVWDPESTTPVLSNIDVEIPAGKLTIVIGQVGSGKSSLLAAMLNEMTTLSGNVHINDEKDGIAFAAQKPWLMNASMRENILFTTKLERKRYKGVLDACALLPDIDILPAGDKTEIGEKGINLSGGQKQRVSVARTIYADRDIIILDDPLSALDVHVGRQLFEEGIMKQLVNKNKTVILVTHQLQYLSRADLILEMKDGRIVARGSIDDIIKADPEMYEEIKQVSAVGWNDSQAESAEEERSKLKRSISVVSAELIQGDGKLIQQEEMVRGAVSYKTYMYLMSNIGWAVICFVALAVAMQSSLSVVTNFWLSDWSESGLHPANESDRTYNEYLGGYAGLSIGTALSQVLQTSAIILSFTLTAKRLHMKMLRNIVHAPLRFFDTTLVGRILNRFSNDTQIIDFRLANSYNGFTVSIMQIIASVVVVGIVMPIFLAFVVPIAILYFFLQKYYLAASREMQRLDSTSKSPVISYFSESLGGLTTIRAYRKESTFYNTILTRIDRNTTAFLYLQVGARWLGVRLDLVGALFVLIATLTTLIGSLVFNIISSSAVGLSSTYSLQISQYLNFFMRNRTEVEMQMNAVERIQHYTNVGREDYGGTEPSKGWPHTGEIRIDNVSVRYAEGLDAVIRNVSVFLKSGEKVGICGRTGSGKSSLTLALLRVIDIFEGRIFIDGVNIMSVPLMELRSSISIIPQDPVLFTGPVRANLDPERNVSDDEMWHALEIAQLKDVVSQLDGGLDAVVTEGGENYSVGQRQLFCLARAFLRKSHILIMDEATASVDMETDKILQTIVANAFADRTVLTIAHRIATIRTYDKIIVLDAGRVAEFGSPDELLADEDGMFTALVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXF2</accession>
    <name>A0A913YXF2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044218.1">
        <property type="nucleotide sequence ID" value="XM_038188290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188290.1">
        <property type="protein sequence ID" value="XP_038044218.1"/>
        <property type="gene ID" value="LOC119718866"/>
    </dbReference>
    <dbReference type="GeneID" id="119718866"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13980" checksum="BD8CEF0B4A5D0AC5" modified="2023-02-22" version="1">MFRNTLADLHNPSDDIVYGFTQPDGLQGTRQFHHWPRFGVDEDVLDIPLEDLGHEGRRRRSMYGKRRGFTPEERTKRVILCFIVVIVVIVLLVGGIFPAIFLSNYTNSAVLYSSLTDARIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYT4</accession>
    <name>A0A913YYT4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044557.1">
        <property type="nucleotide sequence ID" value="XM_038188629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188629.1">
        <property type="protein sequence ID" value="XP_038044557.1"/>
        <property type="gene ID" value="LOC119719253"/>
    </dbReference>
    <dbReference type="GeneID" id="119719253"/>
    <dbReference type="OMA" id="CTEHTES"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000132">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF44">
        <property type="entry name" value="LDL RECEPTOR RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037778299" evidence="9">
        <location>
            <begin position="26"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="395"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="480"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="833" mass="91873" checksum="2D9751D5E13A920F" modified="2023-02-22" version="1">MAPLLSPWLLVMLGMADVYFDGTKANTIVEARGESICSYRIDNETKLLTNPVCFLDDQDFVVALATDANENIIFFSDIISGKLFKYRRDQAQPAQLLYGLGSVEGVAVDWLAKNLYWTDFQLNHICVSRYDGNNRAIIVSDDVLNPRGIVTEPFDGLLFWADLRGVSDQEGRIERSDMDGTARFAIVDNDLVSPSGLVIDFQEKRLYFADRGTDKIESVTYDGQDRRVLYQQIGADFFGITIHGDVLYATVWQSTEADGKIMAITYQGVNEGQVLQTLEHTGQALGITTEDMAYQPRRLNGLTGACGGLNGDCDHLCLPTSAARRACGCRTGYRLADDGVSCVTDYSDERFFLVVDSSLNTIFQIDASTDSHDIAALAIDDLVFPVSLAYDHVEGMVYWTDRALSAIRRAKLDGSMTESVLIGNINDPGGLALDTRRRLVYWTDEDKNEIGVASIDFGARVFIDQDLDEPRAIAVDLLNGDVYWTDWGAVAKIERASRDGTNREVLVDQELGWPNCLALDSQNEVMYWCDALRDRIEMSDMDGGNRITLVEFIEEVHPFSLVIYGDYVYWTDWLRHRLTRADRWTGQGLEEVGKEEFLRMQGLVAFETADIFEEESPVTEGGSEVTDYVPASPTTTASPPMNGALNLTVIIAAAGGGLALLVVIVLVVCCVVKCARSKGGRGPDDHVPMSVRSTSFVGSYDPSGLPSPVLANNNPPPLPPARKKSDPIYEDIDEYQKSGAAYQAYLNPAFREGDGDEAASARYVKRITLDDAPKKTAPAPPKNPEQRPKAKKPAPKPPAKPGAKKTQPRPDQTYLTPDAAQEQDYMALRVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZ15</accession>
    <name>A0A913YZ15_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044959.1">
        <property type="nucleotide sequence ID" value="XM_038189031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZ15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189031.1">
        <property type="protein sequence ID" value="XP_038044959.1"/>
        <property type="gene ID" value="LOC119719557"/>
    </dbReference>
    <dbReference type="GeneID" id="119719557"/>
    <dbReference type="OMA" id="DFNKARK"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="322"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="462" mass="51715" checksum="1E2E47AC3D648C7A" modified="2023-02-22" version="1">MTSVTLIDTSRADPSIIRLAVEMPGKPGQLYCWDQNKSLTTIAEEVCHMYNIGNPGDYALQHTDVKLTYITEDNRSELTNGIVLKLTDSPGKTAQDVFSNLQSENPEDTQQALQKLSKASADITFAQEFCNRGGGDLLIGMVEEGSGQGEALAFTLASFLELMEHSIIPWENITMKFIKRIASYVNRTHSAVLQPGDSTVTLKALAILESLILSSADLYNTIANELTFQNLVPHLESNKHPVIQQYCLALMNALCLRAPEDRKKKLEDSLSSKEIRTVIMEKIVRSQSVGTEMQHQLYVFQQLTFNLLEKKMNTKIDSNNDKHRENIIDLRRIAFGTDSDTRKPGSGSVSANDYKKLGFTNTGNPTLDFMAVPPGILALDCMYYFATSHNESYTKVVLENSCRADEHECPFARTSIALTRILCEILKVGEAPTETGQDYFPMFFSCDNAFKEFFCQCIRLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZB9</accession>
    <name>A0A913YZB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045059.1">
        <property type="nucleotide sequence ID" value="XM_038189131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189131.1">
        <property type="protein sequence ID" value="XP_038045059.1"/>
        <property type="gene ID" value="LOC119719632"/>
    </dbReference>
    <dbReference type="GeneID" id="119719632"/>
    <dbReference type="OMA" id="PGAPWLC"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="360" mass="39875" checksum="4832AED3512CC090" modified="2023-02-22" version="1">MENATENASLVEVTWSAYSTEGDSEGNQIFQYFFERQALAGMFLTGAILGTVGNCFVVAAVALSKKLRTTTNVFVVNLAVADILTSLFIPWQTVAFLGGDAWPIPGAPWLCAMGGFVIVVTFGCSINSLALIAVNRWVGITKSRFTTRRIYTARKLALMVIFSWAIPLGCALTPVLTDFGELGYEKLYSSCTWVIEESVYYSMFITAMYYPIQLILITVCYSSIFCYVCKSARRMTRAGAPSISEEVSGGANRAMRRKLWKRQVDVTKNLLYIVLAFVVCLTPYFVTIIFSSDWSRQLVPWAGGIMFCNSCVNPFIYATSHPVFKEAFGYMVRCQKIPRIKSSPTASTDLPGANTAETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZM8</accession>
    <name>A0A913YZM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045159.1">
        <property type="nucleotide sequence ID" value="XM_038189231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189231.1">
        <property type="protein sequence ID" value="XP_038045159.1"/>
        <property type="gene ID" value="LOC119719731"/>
    </dbReference>
    <dbReference type="GeneID" id="119719731"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="427" mass="47832" checksum="420649B1386F2BDC" modified="2023-02-22" version="1">MADGHDGFSVAEKGYTTKQVPVIIRYVPAGIAERLKSDESFAQTFCATVQRPGRTSQPKTRETPPLTNRTGQPRLHEAGRPHPTQSSITPGQETEAGPSSVGHDESFAQTFCATVQRPGRTSQPKTRETPPLTNRTGQPRLHEAGRPHPTQSSLTPGQETEAGPSSVGHDESFAQTFCATVQRPGRTSQPKTRETPPLTNRTGQPRLHEAGRPHPTQSSLTPGQETEAGPSSVGHDERKTWSDRDSTLLVSLRVKMEDSFHGTKAHKVLWNKIAKEMQSKGCLVTTDHCQNKWKSIKREYKQTVDHNSQTGANRKICKFYTELDELYGNNESTRPSMTLSSCSVPSTTGNLLDETEEPAEKVAKLPIGRKSRKPTKLPNVVDWLNEFHKEQRERDKRREEMVREHNRQKLDRFDRLLDILAKSKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZS0</accession>
    <name>A0A913YZS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045199.1">
        <property type="nucleotide sequence ID" value="XM_038189271.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045200.1">
        <property type="nucleotide sequence ID" value="XM_038189272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189271.1">
        <property type="protein sequence ID" value="XP_038045199.1"/>
        <property type="gene ID" value="LOC119719782"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189272.1">
        <property type="protein sequence ID" value="XP_038045200.1"/>
        <property type="gene ID" value="LOC119719782"/>
    </dbReference>
    <dbReference type="GeneID" id="119719782"/>
    <dbReference type="OMA" id="YQVHWPF"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19085">
        <property type="entry name" value="AKR_AKR11B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="338" mass="37707" checksum="54E209E6835E0A8C" modified="2023-02-22" version="1">MERVALAGSDLMVSPICIGTWQFNGGKADETWPAQDETVSKAIVDKAIELGVNFFDTAEAYGLHESERVLSRCLAGCRQDVIIASKFGRHEGGKVKEYAATDIEQALTASLQALQTDYIDIYQIHWSVNMRDVHETVAELNRQKSLGRIRQYGICNFGSSSIEEFFATGGKPCSLQVPYSLLWRAIEYNILPTIRQHGLSVLAYSPLQQGLLTGRFHNASEVPEGRRRTRHFSSDSTNLSRHEQKGAEEETFKAINDIRDLCNKENIPMSSAALSWILSQEGAASVVVGCRTPQQLEDNCKLIKLSQSVVKRLSDCTAELKEKLGDNPDMWAKTSRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0L7</accession>
    <name>A0A913Z0L7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044546.1">
        <property type="nucleotide sequence ID" value="XM_038188618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0L7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188618.1">
        <property type="protein sequence ID" value="XP_038044546.1"/>
        <property type="gene ID" value="LOC119719244"/>
    </dbReference>
    <dbReference type="GeneID" id="119719244"/>
    <dbReference type="OMA" id="NWIDAVI"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36011" checksum="9A88D30933B75937" modified="2023-02-22" version="1">MASAENAMEDILTVTPMEEGLNVTDTDEASAYLEYGVSTTFIICVYGVNIILTMTINPVCLLVIRQMANMQPTTKNFMTLLLVSKMGFGIFVLIPSMIRTYVVFAEGSFWWILGFICNVVFTLQSFLSLLILTVDRYLAVAWCLHYPRLMTIRRSKIIISISWAVGLIYGLIFIINASSDAGIILNFTVIVIIFIGIVLIVTLYLHILVIARRQARRIAQDNQAVAGNNAPQRVSTKSFTTIFIIVTVVLLCWIPVCLLDLLATSGVSVSPVIFRGSQVLFTTTNWIDAVIFCARNKEFQETVPKLTRTCFRAMRHKLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0R4</accession>
    <name>A0A913Z0R4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0449 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044260.1">
        <property type="nucleotide sequence ID" value="XM_038188332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188332.1">
        <property type="protein sequence ID" value="XP_038044260.1"/>
        <property type="gene ID" value="LOC119718904"/>
    </dbReference>
    <dbReference type="GeneID" id="119718904"/>
    <dbReference type="OMA" id="FIQMNEY"/>
    <dbReference type="OrthoDB" id="6129359at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028227">
        <property type="entry name" value="UPF0449"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34766">
        <property type="entry name" value="UPF0449 PROTEIN C19ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34766:SF1">
        <property type="entry name" value="UPF0449 PROTEIN C19ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15136">
        <property type="entry name" value="UPF0449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="139" mass="15635" checksum="1E2229B28954F782" modified="2023-02-22" version="1">MSSKKMKMIQPRPEPPGLDSVRSDLEKAPNDDVVFTFFKSVLNDDQTETSTKASLPRSQHVESSSDVLKSSLASELSSAVPTKQRSQDLDHCYKQTLEFIQMNEYLKDSQDTLADQATELQRLGQAIKEQVESLRTQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1A3</accession>
    <name>A0A913Z1A3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 177</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044455.1">
        <property type="nucleotide sequence ID" value="XM_038188527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1A3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188527.1">
        <property type="protein sequence ID" value="XP_038044455.1"/>
        <property type="gene ID" value="LOC119719175"/>
    </dbReference>
    <dbReference type="GeneID" id="119719175"/>
    <dbReference type="CTD" id="80775"/>
    <dbReference type="OMA" id="VTSRWEI"/>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33671" checksum="CA88FEDF4318B3B4" modified="2023-02-22" version="1">MVFQRFLQFVRRPRNAVLVSGLVATGVFCVKATPHIFPAKAYRPLVEAYKGGHKIPPTDSQQSEFQNVCQDIGVDPGSYDVFVTSRWEIRSRGLPWLPNGVQFGVPAILKDDPDLSARRFANPIKTTADTEEGRDFRNSLSLSESARKFTLAREVVKIKRNTTASSVAIAPIITLANFAGVFAAQVFLPLPLYANVAVVGTCFVVIYQFLMGVVNEREDLIADDKAAKLGEDYIRGGLEFYEKTIQKNIALRKIMGKRGEQMYTYYGNEVPGWIYSSGASNTQKRDKLKRSLEEIEKKGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1X3</accession>
    <name>A0A913Z1X3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045854.1">
        <property type="nucleotide sequence ID" value="XM_038189926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1X3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189926.1">
        <property type="protein sequence ID" value="XP_038045854.1"/>
        <property type="gene ID" value="LOC119720285"/>
    </dbReference>
    <dbReference type="GeneID" id="119720285"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="257" mass="27993" checksum="4DB82BB1FB80EC22" modified="2023-02-22" version="1">MDAQSASASQRADDQAPCLPDSPLRTGTIGNSGTVIGSHNPIIAGSSAVNITNIFPLEGPGVPAPRPQHSQRPDQEPRLRAPSFQDVGKKTRDILKGVYKTTGSYVQLLPGIDNDQMHIAGIYTKVQLETREGVAVVTGQKGDTVNSTEYAKIFRLRTRVGELISRLIFYGMGGVGKSTIFDKIAFDWADEASEFLIRFQLVFLLKMCALLQDSDIVDSTFDQLLGEDSGIAKDELDEFILANPNKVREPHGTTGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3C3</accession>
    <name>A0A913Z3C3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045506.1">
        <property type="nucleotide sequence ID" value="XM_038189578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3C3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189578.1">
        <property type="protein sequence ID" value="XP_038045506.1"/>
        <property type="gene ID" value="LOC119720058"/>
    </dbReference>
    <dbReference type="GeneID" id="119720058"/>
    <dbReference type="OrthoDB" id="6365500at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="507"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="771" mass="84367" checksum="CCB5234E58485445" modified="2023-02-22" version="1">MNPTTPGTRSAKNRATTSQEVDDHGGDRPVRMSPSLASRETQLGGDRPVRMSPSTSSSITQQLPRQVLGNFPVVSLSPLGFYRLIGTPDSDPQNLSRQGGARPGRMSPSDETKDGPRLRILSRQPANPPDPVQTGSKGPAASTSIQDQARAGLRAAFFEAQPSAPVKLPRGETTKQQVPLRKARQTTQLEARQQTGESSRTTRAKDTKVRFDPTSTAEQPTGVTIQHPRDGRSSPQQTTAYTGTVAPAIPDVNATLTTPPAPSGAAPPSTPRKCTRKRKHLGVILSPPTETSKRMRTSSPLSDEEEPETMTAKQHVTIGVQTGSMIMTGNMGRTSPHETTVKRRRESPCQPTLPFKKRKFESVTSLESHDNRPSTSQTSESVDCLPRKHNHNQQRSRGIHPRCAFIRSILPPIPPSRQTTRVPTPERPLRGFTSETITQLMGLVHQVSCKRKLNIGPMPSPEEGPSPNKKPKSSTESSPTPPAPSPISPINIPCLDPGDVESVLNDQGCPVSLGAGDFGEVLLMRKKSDGGLLAVKRLKCSNCPQKAYREMLVEIKAMMAVSGLKEFPRFMGIVDESTFAMEFVGDSRTYSAKSVHSCMLDRSILTIADRARVSIDITRGLMELHQSGWLHNDLHNGNALVCTDSTSCQPTAKIIDMGKASKISNPPPPNRFCKNVKAYYYKNCQQIAPDIVEGISQVSEASDVYSLGILLKDIALNIRDLKYVRNLGIRCCHKNPARRPTLATVLGDLKKFQEKLTARKIKETQTKYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z590</accession>
    <name>A0A913Z590_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor IIA subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046176.1">
        <property type="nucleotide sequence ID" value="XM_038190248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z590"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190248.1">
        <property type="protein sequence ID" value="XP_038046176.1"/>
        <property type="gene ID" value="LOC119720535"/>
    </dbReference>
    <dbReference type="GeneID" id="119720535"/>
    <dbReference type="OMA" id="EVCDASQ"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000002">
        <property type="entry name" value="Transcription initiation factor IIA subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36086" checksum="E2EC4573A1EEE213" modified="2023-02-22" version="1">MANSQAVFKLYKSVIDDVITNVREAFLDEGVDEQVLQELKQIWESKLMMTRAVDLTPQPLPQSVTGNRHHGKSHGGATTSGNELQLQTQQRTAAEVGRSIPQQQGTQAFQISGATTQLSSPAAAATLAFQQGMMQLPHQLTSIPAGLTLAQPQGGTQTFPAYAISQPHGTLQAGAYQAVLPTGQTVMIHPSPQTTQTQQQQQQQQQSQQAGGSINLTTVQARVLQVDGANDTSDEEDDEEEEDDHGDEDDENEDNEDANDVEEESLNSDDDVSDEDPEELFETDNVVVCQYDKISRSRNRWKFHLKNGIMNLKGRDYVFFKATGDANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5Z3</accession>
    <name>A0A913Z5Z3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047137.1">
        <property type="nucleotide sequence ID" value="XM_038191209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5Z3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191209.1">
        <property type="protein sequence ID" value="XP_038047137.1"/>
        <property type="gene ID" value="LOC119721238"/>
    </dbReference>
    <dbReference type="GeneID" id="119721238"/>
    <dbReference type="OMA" id="MNIVKDY"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="43850" checksum="60ACEB21A5B34067" modified="2023-02-22" version="1">MATVDELKERIAQLEVELAKEREKTGGNVAGARKKIDQMSSEVVDSNPYSRLMALKRMGIVDNYERIRDFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGMSKVQAAEKTLRDINPDVQFETHNYNITTVDNFQHFMDRISHGNLKGDGSVDLVLSCVDNFEARMAINTACNELEQNWIESGVSENAVSGHIQLIKPGETACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGVVAGLLVQNTLKYLLGFGSVTHYLGYSALQDFFPTMSMKPNPACDDSFCGKRQEEFQRKEALRPKTVEVVKEEEIVHESNDWGISLVDESSVDDLKTQPAPELASGLSYAYDKPDETTKDSDEVVADTDQSLDELMAQMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z830</accession>
    <name>A0A913Z830_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Retinoid X receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047952.1">
        <property type="nucleotide sequence ID" value="XM_038192024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047953.1">
        <property type="nucleotide sequence ID" value="XM_038192025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z830"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192024.1">
        <property type="protein sequence ID" value="XP_038047952.1"/>
        <property type="gene ID" value="LOC119722036"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192025.1">
        <property type="protein sequence ID" value="XP_038047953.1"/>
        <property type="gene ID" value="LOC119722036"/>
    </dbReference>
    <dbReference type="GeneID" id="119722036"/>
    <dbReference type="OMA" id="CVINKYT"/>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="175"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45973" checksum="FF42CF94E94BB4FA" modified="2023-02-22" version="1">MDTEAQLPNSSTTAAESVTSSLDEDISSTVNNECMVCSDKATGLHYSVNTCEGCKGFFKRTVQKQLKYACRGIGHSGGCLITKESRNNCQHCRYKKCLSVGMNVTAVREDRAPGGRPHAKKLKSDPTTPALEPEPQAQDQATERSHCEDILDAASSSEEQDSRHDDIMAPDKSNDMMQLLEELKASRPDIIPVGGSQDVEGPGDEAVGEQASDEASSMMQCGYKELQLIIRWAKKVPGFTDLSIGDQMCLLKSSFMELNILRLAYRSMATCRNKILQFAEGVVLNEEETVKMGWDLELIKSTCTFAKRLSEMNVDYSDFCLLNALILSFPDAAGLQDKEVVQRLQARFMDCFYFYCQTKRPQDTKHYGQMLLRLQALRALSAKAANCFFDMIDKGTLPVDPLAQEMFVDGFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z833</accession>
    <name>A0A913Z833_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047166.1">
        <property type="nucleotide sequence ID" value="XM_038191238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z833"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191238.1">
        <property type="protein sequence ID" value="XP_038047166.1"/>
        <property type="gene ID" value="LOC119721255"/>
    </dbReference>
    <dbReference type="GeneID" id="119721255"/>
    <dbReference type="OMA" id="CTQANSF"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052309">
        <property type="entry name" value="C-type_Lectin_Domain_Fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490:SF6">
        <property type="entry name" value="ASIALOGLYCOPROTEIN RECEPTOR 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46490">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037618556" description="C-type lectin domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="19036" checksum="FA1CF7DD95F70B77" modified="2023-02-22" version="1">MQVFSPCLLVLLVAGLAAAQRLNNCPTMWSGAGEYCYQFFKQPLPWQEASNFCSKFSSCATGAAASLLKLDSAQADTRLEKFLSPKGNPSPPNTWIGLGDPMNTGQLTWPDGTTTQSVGYNNFGQGGRNGNCALKDTRTNQWTFAPCTQANSFVCQMQRSVPPQTGGPGTNFPSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9S3</accession>
    <name>A0A913Z9S3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047635.1">
        <property type="nucleotide sequence ID" value="XM_038191707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9S3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191707.1">
        <property type="protein sequence ID" value="XP_038047635.1"/>
        <property type="gene ID" value="LOC119721740"/>
    </dbReference>
    <dbReference type="GeneID" id="119721740"/>
    <dbReference type="OMA" id="FPVGESW"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="459" mass="52368" checksum="0A4EBDB2846D6925" modified="2023-02-22" version="1">MFHQVRLLPEERRMFRFLWKDDQLDKWVVFEWMVLPFGAACSPCCAAFALQKAARDRVEQYPQVQYTVEKETYVDNQLASRDSEQEATELVLGTRKCLQKVGFQMVKYASSHPNTLQGLPVEACSTRQVQSLSLGLQEGDPEPALGLCWDWKSDELHHPAKVPDNQVLTKRIALRVLASQFEPLGDIAPFTARAKLLVRDLWLEKLDWDERVTDTGLTQRWEEWCTELEHIPQMRLPRCYTPPSVDTATAKRSLHIFCDASEKLYGAVAYLRTVYSQGEVHLSFVLAKCRVAPKRLLSMPRLELMAALLGAQICQVVLEALTIEIQYSVMWSDSTTVLSWIQSESCRFKVFVGTRIAEIQTLTDDIEWRYVRSEDNPADDITRGLPVCKLGEGSRWTEGPKWLLDPQEEWQKDSASVLAQTRVNSSVGQNEIRSVFCGLTVPTSEVDVDFKAFPVGESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA97</accession>
    <name>A0A913ZA97_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047810.1">
        <property type="nucleotide sequence ID" value="XM_038191882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA97"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191882.1">
        <property type="protein sequence ID" value="XP_038047810.1"/>
        <property type="gene ID" value="LOC119721927"/>
    </dbReference>
    <dbReference type="GeneID" id="119721927"/>
    <dbReference type="OMA" id="PAVTHEN"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="695" mass="77605" checksum="4548292D9E6ABF45" modified="2023-02-22" version="1">MARWLTHCHQVHVRDVGRKALDLLTEGLGSRPGVANTMRTPCNMRLVNRLRTRWCSSSSAASTMDYLHALSPVPTMIFQPAIPQVPIPSLQDTCQRYLASQWAFLNPREFAETKTLVGEFEKGAGVDLNNELLELNKKNSHTSYITDFWMDVYLRYRDSVILKTSPMTFITNDHRPEYMDQTIRATNVIVSLLRFLKTLREDKLFPDVVHKNPAVTDTEGFWRSFRSLSAEDAYRHAVDSSVQPLDMSQFTRIFNATRIPRNNRDELYKDDTKRHLLVIANSHMYVLDVLDSDGSLVPLQDIRANLQYILNHSSSLPPPEHPVGYLTTDHRDTWTRLREKLLAACPDNEETVRLIDSALFCVCLEDDTDDSKEQLARKGLYGNAGNRWFDKPFQLIVTSDGQLMTNVEHSWGDGVTLKRLFTDAYEDAVSRPAITPGGTAHTSSIDSSKSVSKLEFKLDSALCQGIKEAKANHALATSQLNVQWMQYPRYGSSFMKKCGVSPDAVAQLALQMAYHRVTGGVAATYESCSTSMFKHGRTETIRSATAETKRCTEAFYKNSGVNMDKKRSLVQACSDKHRLLSKEAILGQGWDRHLFALRCLASVTGRPMPAVFQDPAYANINTITLSTSTTGVSKSSAGAAFAPVSPGGLGVAYTVTGDGVSWMGTSYSASPSLSDFARSVHEAYDDLYEVMSYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAZ8</accession>
    <name>A0A913ZAZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048065.1">
        <property type="nucleotide sequence ID" value="XM_038192137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192137.1">
        <property type="protein sequence ID" value="XP_038048065.1"/>
        <property type="gene ID" value="LOC119722111"/>
    </dbReference>
    <dbReference type="GeneID" id="119722111"/>
    <dbReference type="OMA" id="DVQSHEM"/>
    <dbReference type="OrthoDB" id="3066195at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="31037" checksum="E75A6BD3943690CB" modified="2023-02-22" version="1">MSSAQEFDPKQPQPAADDQDNDDASEGRETDDFHVAMDGLTKRKATPFTSTMDVALATAYTTEKNILDGTLREHGVPSRQQKMAAWERIRDCVNAFSGDTNQKTVQQCKDRHRNLIQAVRFKRSSGFLEGPLPMPSDVQSHEMGDQQSQLGHQQQQNRDSTSESIKASQQQVRPPEAANGIPSTSAPAHSPKEKRPLKRPSTSSVDTLDDYRKRKLAIMVKEHIARVDLMKAQAEYYRTKTELMVKHSCSRPTSVTSNSQSKLPAPHLHLHPNLPGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCL1</accession>
    <name>A0A913ZCL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049522.1">
        <property type="nucleotide sequence ID" value="XM_038193594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193594.1">
        <property type="protein sequence ID" value="XP_038049522.1"/>
        <property type="gene ID" value="LOC119723085"/>
    </dbReference>
    <dbReference type="GeneID" id="119723085"/>
    <dbReference type="OMA" id="LSYILMK"/>
    <dbReference type="OrthoDB" id="6282848at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027877">
        <property type="entry name" value="Smim15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28644:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15086">
        <property type="entry name" value="UPF0542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="99" mass="11563" checksum="CD2BC8837AAB73DF" modified="2023-02-22" version="1">MADGADDPTEPKNLDDFPGEDDGTWRYWFEKNIILWVAKDPYGFLYTVFLFLTPLFIISAILSYILMKDIDKKEKEKKRKAKREANIARARGRSSKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD76</accession>
    <name>A0A913ZD76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase 47</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin thioesterase 47</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-specific-processing protease 47</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038049001.1">
        <property type="nucleotide sequence ID" value="XM_038193073.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193073.1">
        <property type="protein sequence ID" value="XP_038049001.1"/>
        <property type="gene ID" value="LOC119722767"/>
    </dbReference>
    <dbReference type="GeneID" id="119722767"/>
    <dbReference type="CTD" id="55031"/>
    <dbReference type="OMA" id="CEWIVSK"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045578">
        <property type="entry name" value="USP47_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF702">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25985">
        <property type="entry name" value="Ubiquitin_USP47_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19718">
        <property type="entry name" value="USP47_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="189"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="871"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1405" mass="158632" checksum="F9E813BD99B5E6CE" modified="2023-02-22" version="1">MVPVNSTQLVPSEASCSADDRMILCIIRDITNPQWNSCKITVTLPIRTTTRDLCDEVAKQANYEPDTFNLVWQRSGADGTDDVLMNDRGTQTLGEAGLLPDRKKNLFQIQDKEGVQPVPINAGATGITVTNGDDNFAAMATAASSARNDGEDTQPLITAPSVDTCATFTDYSYSSYASAVTAKSESGYVGLINQAMTCYLNSLLQTLYMTPEFRNALYKWCFDESVEDPTKSIPYQLQRLFVQLQTSTKRSIETYDVTRSFGWDSNEAWHQHDVQELCRVMFDALETKFKNTENEDLINRLYQGQMKDYVKCLECGHESARKDSFLDIPLVIRPFGSTKTYGSVQEALQAFITPETLNDTNQYFCEHCNKKCDAHKGLKFQSFPYVLTFQLKRFDFDYSTYTRHKLNDKVTFPELLNMNTFLEDEKQEEDETDVQSDREADDFESPSILAGPGQNHSPDDTVDEGIDVEQAAQVTTPSKSQPAATPYLYELFSIMVHSGTANGGHYYAYIKSFSDGRWYCFNDTSVTRSTQDDIRRTYGIEALPGRSAPNSTLPNAYMLMYRRVEPNKNANFTTVEQFPSHIKELKARLQSEEEEERRQREIDRNTCKIKLFGVHPLTGKSVEARLEVHKDKTLREATEMAHKLLCYDKHTPLECCRLVKYDEFHESLERSYEGEEETPMGTLLCGVKTTYMFDLLLETRREDQEFVVYRPGGVTNKLFVVDLEAETIANPISLRSYVNTTIQDFKTQIAEVTGLKVETMRVVWEKYYNDLKPLVSGHKTLKNEGFLKSNKVFVESSNIEDKRVPFMDSKLYQLLDRNANTIRLQVTLPLFYQDEFKPPKSNSNSVSPCPSLTSSTDEKYNDLQLETDIAMNTAPTPSPTGSSSTLSDDHPLDKNSANLLGSETDSGVVSLNDGRTHDDLSGDNDGNSGELRGSPEGAVDGDASPANPTRSEDVGDVHIPERDVQSQSGTVDATSDPCWCEGRGCGDCSKLQRGNSDQSSGAVSSPLSPLSSISSPMTTTSDNKSGSIPSDTDPGAGGETRGSVIKYEDPNEDSEDEIYENTRHTKMSNWYFKAEPIQTVDNSRLMPVYVDKRMSLAVFKKALEPYVGTESQNFKVYRVYANNQEFESIRLTETLQSYSEDSRVVVKLGRALKKGEYRVKIYQLSANSSEPCKYLFDWVFAKGMSVQQSKTELLPELKAKCLIDVPLNRLRLRKKAWKNPGAIYADTQLYEEDIPIFTNWEVFVEILDCPEPVTDPNHLELFVRRWRPSEFKLDPFEEIILTDCTVDDLKKELSSRSGISQENVCFAKGKGTFPCEVSLLEMQTDLEWNPNVTSLNSWPLYISDDGAVVYYCDGSEDLKELTEEEKQDIQKKENSRLEKTSQKPNYPSPRKERALKIYTDLSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD93</accession>
    <name>A0A913ZD93_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048910.1">
        <property type="nucleotide sequence ID" value="XM_038192982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192982.1">
        <property type="protein sequence ID" value="XP_038048910.1"/>
        <property type="gene ID" value="LOC119722719"/>
    </dbReference>
    <dbReference type="GeneID" id="119722719"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="708" mass="79607" checksum="4632E1ED8135D7C3" modified="2023-02-22" version="1">MAETLRTEELMNYRRLDSSLPRRGPKEKSPDGSQRQEQKLRSLHEQQITLLKERRVAKLSNLAIGEWSPCKELVEVKVEKGKFWQTMGYHSGGRKYLYAEEGLFLLEMNGMELRHRGVPLTMQEAYELMIPEQFSLEHYQVYSHLMRLGYITTRHKENDITDYEYRIRLHQYRHNQNKVYRKVQGWFQQMDDDTKTDMQEEVIDRYGDTSAHTSIPEGQQTSNDMSNSSFAGVSSRASNDQAVTGDAMNSGGFPPLPGSETSSSSSINNLPSEASSLYSDSPVMVRPVRQEGFGASINLLNYHKMFLQASDNVADDSVKRSLPSSTSYTESDEKGKEEEDLEHSKKRRKLDLDNELIVYSDSGRDSSVKTNQALYRPPSSEDSPTKCNPLKEYPLNFQIKKEDFDKLLRPSNTPWESSDLGTSHPSCTPSVNIDDVLDTFLPTFNDRSDSDSMSCPYSSWNFQTIKLPNLADGKWSENYSAFFKDCKSKEIPASKDKKSDMSDENAEQLMKASQELLKTSAKMIATSGKMMANSGKTASSLEDRAGFMKNKLPTNWGEYKKLLMLGVEEDSQDLLECPTAHLWQGDVKPLVHPSEATYTGNLLSKLQVISSANVSSEHVRLSPPLGSSIKLAFDVFLSSPTHKKTQPGRPKFHVVVARVTDAVPDLFTLANLLQQASAITLLVAVVDNGDITFYTLKGIELSTDISLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDJ6</accession>
    <name>A0A913ZDJ6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049131.1">
        <property type="nucleotide sequence ID" value="XM_038193203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193203.1">
        <property type="protein sequence ID" value="XP_038049131.1"/>
        <property type="gene ID" value="LOC119722840"/>
    </dbReference>
    <dbReference type="GeneID" id="119722840"/>
    <dbReference type="OMA" id="TYRPMWT"/>
    <dbReference type="OrthoDB" id="9890094at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038102924" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="396"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="749"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="881"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1214" mass="130913" checksum="B407303A37C105B5" modified="2023-02-22" version="1">MDAFLKLLLIALVAGFAQIASSTVTLENCPGNIYSKTGEASFTLPTAKADPGVDVTKLECDHAHEPTFYTEYVTKVICTAEDAEGGKASCEFNIYSPDGAGCPKRQDATNDKCVCSPLRAFFDPCECVGNYSGLTCQVLNADKCTGTSDPPSCDCSSSPCNCKDGFKGETCEIDFQAPMITCPQDIFTREESVQLPPKDNLIVSDNDGDEPSVKCSPELGTFVNSTGNTIRSVTCSARDTVGNRADCSFKVVIDVEPPRIPYCPGIIHTNNSQHEWPVDIAVDNSHQKLNVTCEPKSGDPLTDYITNVTCYVQDMAGNAAEKNCTFKIYLDGGTCSNSDANCDCNSGCFCKDGFSGLTCEVEDGSDCASSSETGPGCVCDGGCTCRDGYKGANCDIDYQPPELSNCPFGEIWSQIPVVTYRPMWTKDNNDTNAPTTVTCYPEEGSEFYDYRTDVTCSAEDESGNKESDCQFPVRRNSASECESDGNNCYNCQSRCRCMPGYRGPKCQVCADCDNGGYRENPEDCQCQCKGLYHGLDCAECYEPNADHCLNGGTFVMDTCSCDCAGNWTGRHCDQMPGDECLSVPPADRVGCLCSNSICTCEPAYTGPKCDTCKPCQNGGNNQDSSTCICTCPGYFIQPLCLDCDTSVVCQNGGTLDENTCTCQCVDGWKGKDCSEAATFGDKCPSDIIMQPDAGQTTAKVTWKDPTETDASVECQPASGSQFQDGTTNVVCTATYTGGTTSSCFFKVIIDGRAPFVNCPADMEPYHQRWKDTAVISWASVTAEDEVSGTLPATCIPPSGTVFGSSTVVCTASDQAGNLGFCTFDVTVYLRGSTTRFPTSMSCRKCYNGNPYGRCTYQEDDDEYVCYCSSGYTKDADGICQDIDECEENETCDSNAKCVNTIGGYRCECNDGFYGSGTSCREFPYETYPDLPEPQANEPPFEKIISIDVSIASESMFGCDMTNDPTSSECKILHTVFTQNLREKYLEFSPALLRIELPQSNTRKGNFGHTVVYDYSRLSASQKATSAQDFYGETIASSVEDGELGGLKLVKDCTECAPPKDLTNLCGNNIAKPECGDGYFLKKVESADKTSCYYACDSLCTTDYCSAGTCVHNPPFEAICRCPDNTFGPNCEPITVTTDKDDGGGGGGGDKKDKLDLPLILGCSIGGGVLLILILVIIGYLIYTKNNAKVKKSYVENGKANEAFSMEKTHQVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDQ6</accession>
    <name>A0A913ZDQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049085.1">
        <property type="nucleotide sequence ID" value="XM_038193157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193157.1">
        <property type="protein sequence ID" value="XP_038049085.1"/>
        <property type="gene ID" value="LOC119722805"/>
    </dbReference>
    <dbReference type="GeneID" id="119722805"/>
    <dbReference type="OMA" id="INEIPWG"/>
    <dbReference type="OrthoDB" id="10039713at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12823" checksum="0B8A2D2F9D41AEC0" modified="2023-02-22" version="1">MYRRQIHEQLLIAVEQGDLLNVQLAVKQGANINEIPWGMESVLMRAIRCRHSPVAEYLIEQGVDLGYHYEKTSSPRGPTRSMQETARDYAEFYNLPDIVELIDRRMGQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDW0</accession>
    <name>A0A913ZDW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Soluble interferon alpha/beta receptor OPG204</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with host IFNA1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049968.1">
        <property type="nucleotide sequence ID" value="XM_038194040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194040.1">
        <property type="protein sequence ID" value="XP_038049968.1"/>
        <property type="gene ID" value="LOC119723420"/>
    </dbReference>
    <dbReference type="GeneID" id="119723420"/>
    <dbReference type="OMA" id="VYLSYDW"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF44">
        <property type="entry name" value="X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0244">Early protein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="5" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="9" id="KW-0922">Interferon antiviral system evasion</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="338"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="585" mass="65634" checksum="1F68D3B5D43EB39F" modified="2023-02-22" version="1">MIDNAHLDPHTMAASKIRHLLSLTALVTAFVTVFVTSPVRGSAVCQLHNQRDNGNLGFEESDLKQLGYRHKYTELLCGARNFCNIQWTKGGQSLNLSKNVELRDRNQTLVFKSLDEADRGVYTCMASDGKTTITRRVTLIVIESSTSQKPVDLQHQSCSNATANIGGSVTFYCEFLVPKQDCGNSHGSWTMVNKSAPIDDLRYGYVDLYKMTGGTTFNETEYPLEKMAENGAKCQYTDCDSLFGFMLETNNISQDAFGTYRLTVYSSCTDKTEKFLELSYEPPTLLPRVQPKDWHEHLTIPLACVVGVAIIVLVTSYRFRTDFKLRWKDFAGKRDESKDYDVYLSYDWNSETDRSFAISLVKRLEERGYKVSWEMDCLPGGDTDEDILEILKTSSRCVIIFSPDYLASHRNLDVVYTMDNVRNYKREIIPIIYRDISSAMAGEDQGALVKQILSMPCLHYDRLQQSQPLSKAQKIIKSVIGSPYSEKSLNKEMLLRLPPPARTPPPSSAASDLNLVSSEVPQHISSRESVSQYQPSSELPASNGLTTGLLSFPESPRNADLPTILASSNIYPDISRLSSVELSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF22</accession>
    <name>A0A913ZF22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050059.1">
        <property type="nucleotide sequence ID" value="XM_038194131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194131.1">
        <property type="protein sequence ID" value="XP_038050059.1"/>
        <property type="gene ID" value="LOC119723464"/>
    </dbReference>
    <dbReference type="GeneID" id="119723464"/>
    <dbReference type="OMA" id="LYCYIWE"/>
    <dbReference type="OrthoDB" id="6232294at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="330" mass="37150" checksum="517C27844604C4C5" modified="2023-02-22" version="1">MDAEFVLRIVRTIVGCLGILGNGLVCLVIAKVPVMRTITNAFIFNQAVIDFLASLCLIIKSNCFPTMPSEPTLAVLYCYIWESGYYLWVFFLASSFNLMVLTSERFVAIVYPFKYVKLFGAKQAGIMIAVVWVTAFGYKAYLFATREIRNQVCKERDFTAKQLLGVATFLIEYFIPLLFLGFCYVRIILCLKQGAARVAQQSSSPRHGGESLRGSLVRAKRNTIKTLIIVFMSFIVCWSANQISYLMSNFGWPLDFNGNFYIISVSLAAFNSCVNPFIYAIKYRQFKKSARSLLLPCIPARTNRVMVASTSFNIATRGQNDSELGVNECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFE9</accession>
    <name>A0A913ZFE9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049695.1">
        <property type="nucleotide sequence ID" value="XM_038193767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193767.1">
        <property type="protein sequence ID" value="XP_038049695.1"/>
        <property type="gene ID" value="LOC119723206"/>
    </dbReference>
    <dbReference type="GeneID" id="119723206"/>
    <dbReference type="OMA" id="TNCTFTV"/>
    <dbReference type="OrthoDB" id="444034at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037688020" evidence="4">
        <location>
            <begin position="33"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="94"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="621"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="826" mass="89133" checksum="E32A4CE9135B1FB5" modified="2023-02-22" version="1">MGFAAAMTPKCFLLLVATSFLVTIATVPVVSAAACPSDRTLVTTSGQAYSNAAITTTGLACNNTTPPRWQVGVHTVFCTDVNDDTNCTFTVTVTDNEDPRITCPNDISRQLSVDDRFSVSWNSVTALDNVGVASSSCSPASGSSFKTFVGSAKTVTCTAVDDAGNTATCTFRVTLTDDVPPTITCPGNQTERTTNGEETRDIPWNIQTSDSVGVASRVCSRPDSNTVFSLGTTVVTCTARDAAGNDATCSFQVTILDGNPPVFTSCPTGTINKTIDSTEISWTLPTLSVRVTWDEPSAEDDDGVAPMVESSHSSGDEFPVGITDVTYNATDMAGNTKICSFSVAVEFQPPQEVSETFGTCQPTPCFNVAWTRSQDPTVSEYIISAWKGSQGESEALQDIVPNADSTYIRHEFKKQFSPGELYTIKVEAVVGQSRQLIGTMQQWTMPDMPGTIEVVPGTRSTTSVEVTWPRVSLQNVEQYRITSAGHHSGYVTKTTDKILLDNVFPNIWVNVYAVVGSGDMRKISSGRGKSVSFQDYQEESKLLALSTESTVRVYWKSNQSPSNEPHMLYIEPEDAEENYLTAFSGTQAEFTGLEPNTEYQIRLINNFGLSLSTSVKTKPGPPSNVRPTEVLNNSLTLEWDPPTEGDVESYEVYISPGDSTEPVEVSGTSHTFSSLTAMTEYFLRVVSVYDDVKSLPMTLMVTTGVTKPSPSPPLNIIAIALGVGLGVVALLLIIGIVVTCRKYRKLKAAMNTAAGYERAIPTVAKPATPRVPVKVDVDERRYENAAVADQMADREARGQKKGKSVPMVAMKPPTDYGDEYAYVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFG6</accession>
    <name>A0A913ZFG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038050538.1">
        <property type="nucleotide sequence ID" value="XM_038194610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194610.1">
        <property type="protein sequence ID" value="XP_038050538.1"/>
        <property type="gene ID" value="LOC119723757"/>
    </dbReference>
    <dbReference type="GeneID" id="119723757"/>
    <dbReference type="OMA" id="MIAFEAF"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038155409" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="63129" checksum="28FB47648DA7CB32" modified="2023-02-22" version="1">MLALLAILTVTAAGPLGVLCAGPRVDISGLGAVVGETVHFQRNTYPILDTYVDVYRGIPFAEPPERFAKPQPKKPWSGDLDATKFGTQCPQPLVSTNTGEDCLNMNIWVPNPKPTKAAVMLFIHGGAFLVGSGSEETYNGISLAAYRDVIVVTFNYRLGVFGFLSTGDGELPGNNGMWDQLEALKWVKEHIADFGGDSNRITIFGESAGGVSVSLMTLAKQSWGYYDRAIMQSGTATAPWGVLDPTKARDDAFGLGRNALCFAFGSSSSLVSCLKTKTTDEIMSAATPILLAALFTKNNLIPFVPTIDGEFLTKDPAELFRLGEFKSSDVLLGTQRDEGAMIALKAFLPASLGSDPVISKDQFDGSLSSYVFMEHDQSMLDVISAYYTDSTQSNYLRPFSRLTTDEGFTCPTDTVVKAFAAANSNTYLYQMTHVSSFHFVPLPTWADIVPHADDLVYVFGSTFMSGLERPVLLTAEEVDISVDMMRYWTNFAKTGNPNLESLNHVETPDAKTWHKFNTQTMYYKDLSPSMVDRQNLLKDECDLWNVQLPNMAPSRHASRHAGVVSSDLLSFLMIGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFW6</accession>
    <name>A0A913ZFW6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050687.1">
        <property type="nucleotide sequence ID" value="XM_038194759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194759.1">
        <property type="protein sequence ID" value="XP_038050687.1"/>
        <property type="gene ID" value="LOC119723870"/>
    </dbReference>
    <dbReference type="GeneID" id="119723870"/>
    <dbReference type="CTD" id="9869"/>
    <dbReference type="OMA" id="CEPNDED"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21181">
        <property type="entry name" value="Tudor_SETDB1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20384">
        <property type="entry name" value="Tudor_ZGPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040880">
        <property type="entry name" value="DUF5604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041292">
        <property type="entry name" value="Tudor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041291">
        <property type="entry name" value="TUDOR_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18300">
        <property type="entry name" value="DUF5604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18358">
        <property type="entry name" value="Tudor_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18359">
        <property type="entry name" value="Tudor_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MBD" evidence="20">
        <location>
            <begin position="1133"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="18">
        <location>
            <begin position="1265"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="1341"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1808"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1049"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1404"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1523"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1696"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1523"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1542"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1567"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1591"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1630"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1641"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1706"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1717"/>
            <end position="1726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1824" mass="203473" checksum="AF57913BD52E8F19" modified="2023-02-22" version="1">MMDEVYHWNELPAQVEAVLSEVWIKLDVDKQLQQAQEKIDQINNGHSEIGEIFDSVEQGLIDIENELHPTKANGERTRFYADVADSMSKVKSDLQDLHLKIDALETCHDDANDDQTSEGVFVFVDSDDDSSSQPSPKCPSDKDLELMDATCNDTEKKETGETNHCDADSQQASTDQQAILSTDTKPCDNVTANKIDSTSSSRQDASQDVCEPRTVQGGSKQIDASSSVASHQQTVSAAKPVTSVDKPSANTHSKQSTTVMSKPKTMHVKPEPGSKTSESLKSVTASQPKPYNVGEVIDLCDGDDSSPMEDDQDVIECIQTKIKTTHIQDSSIQLTQGSRVLAKNMKKGDTWHDATIISIIKDNTSQQKFKLKFDSKGNSLVSGKHIAVKSFPKPSRVHVGSRVVAECESGEKTSQCTLYAGIVAEVPLHSNKARYLIFFDDGYTQYHGLKKIHLVHEASDNVWEDVPEDTKEFIQEYLEKYPERPMVRLHRGQCVKTEWKGVWWRAKVIEVDGSLVNVNFPNDGRNEWIYKGSPRLEPLHRELETAKYLRESGRLIAGSSVSKKRGGPCVEYQRVNPDFLVSENDILALAEGKKPLIRPETTSQFSQSKGVVSSKIVEKMPVVQWAVITLRKWCESHRVSPTFEDLPNEGLAALLERIYREGPTEEPDVFTSHTLQGLRCSLSTFLTEPPISRKVDIYRDAVFNKANKALTDSVRSQDKDKPVIKKMMIGQPGMSRRDLLKLLKSGLVCLSNPLGLMRLVWLFMQPFVGRIKGKIKSLDLDQLQKKDVLCKVAKSGLPYYEINSPVLGLSGGQEQKIYATGNRFYCPHHAISLYISKLNPDCPDFFQKPRIKSNFKLEAIWFDPEPVKSAAISSLMSVIGAAAKLSRPYNNADIRATPWDNLQDAIEDFSENLRMGYRRNPPPQAQKTSAVTTTTTATTTAGRPVGKQVSPSAVTGKALKPVSQQSAVYIKPEMQQGNVNKPVRKALYQQAATCTTKQPTAQADSDDDVIIIGTTTSDSSASKGASKMSASQCLMQMSNLYKAEFKNERQQTAKKSTSSQSHYHYHHHKHRRGNHRYDTNPYDSMKGKLQVSTRQMHQLTAETRHAKMTFVPHNCSQQCVVASIPDEKRKYKIRKQNPLHVPSMYGWVRRLAKQRGSGRRHVVYRTPCGRSLRTISEVDRYLTDTKTEDICVDAFTFDPFVYTELRKYRVSQRYLEISDISKGSEPVAVSLVNEIDNDQPPDVKYIAHRQPEKGSMIITDPDFLICCDCTDNCKDNSRCACRKLTQRSAQDFPELSRNTSEIGYKYRRLNVMVSTGIYECNPRCACNKQCHNRVAQNGLSLRLQVFKTDKRGWGLRCLDDIPQGAFVCTYAGQLWGAEEANMRGQTFGDEYFAELDHIEVVENSKEGYESDPMEDEGISDSKESLSSNSSNSDQCLTSDDDYRIGSDESETSSIAIDVENNSDDSDELAKEQSGDSSATKMVFRRHQYESGQGSMIEGSCWSVAFPDKDSSQSKVEAWVKRNLSANSDSIATASEESGIDEAAAKMEKDSTESKMQRKGQPDSLADSTDRSYKDGTSDVDYKPLAKKSVGPRREQVAVKRSGRRDSSNKETDSSTSSIIKYGYNTSPGKVLDKSQIDAFKKRSHTSRLHMRKKSKEAGDDMMKTASVVSDGETSGSEYSSTADMKAVKIDSKSMASCVPLPDQQPPIASTPPSKDTGSGKETEKKAQVIRTRSFFGETSGHVMDAKFIGNLGRYLNHSCSPNLFVQNVFVDSHDLRFPWVAFFAKKYVRAGAELTWDYNYDVGSVPGKSLICLCGSHECRGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGF1</accession>
    <name>A0A913ZGF1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050872.1">
        <property type="nucleotide sequence ID" value="XM_038194944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194944.1">
        <property type="protein sequence ID" value="XP_038050872.1"/>
        <property type="gene ID" value="LOC119724022"/>
    </dbReference>
    <dbReference type="GeneID" id="119724022"/>
    <dbReference type="OMA" id="MCIRSAK"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="203" mass="20625" checksum="D634F1BD60ACE05D" modified="2023-02-22" version="1">MCIRSAKNTPKIRRAKIDYRRKYATKPGDRLGLPSPTGDGPGLLSPTGDDPGLPSSTGVGPGALCSTGDGPGLPSPTGDGPGLPSPTGNGPELLRPTCDGPGLPSPRGVGPELLSSTCDGPGLPSPTGDGPGSLSPTCDGPGLPSLTGDGPGLLSSTVDGLDYQVPRVMALDYRVPRVMALDYRVPSVMALDYRVPRLLALNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGI0</accession>
    <name>A0A913ZGI0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050156.1">
        <property type="nucleotide sequence ID" value="XM_038194228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGI0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194228.1">
        <property type="protein sequence ID" value="XP_038050156.1"/>
        <property type="gene ID" value="LOC119723525"/>
    </dbReference>
    <dbReference type="GeneID" id="119723525"/>
    <dbReference type="OMA" id="HIYNHEL"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="110"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="405" mass="45095" checksum="8FE114A9EDC63846" modified="2023-02-22" version="1">MNSSWVILTVLLAYVCFKLYTPVPDAIEEKLKFRAFVALPRIFRFVGSVIGLFNGKNSLQNMQELSAFLPRPPFDVEGSNIRSEVVTFDGVRVLLYEPINRKGRGAVGGLMFYHGGGYMLGSPETHDGLTRQIAEELDVVVASVEYRLATEQAFPAAHEDCMTALRYFLNHAADFGVDPSRIGVAGDSAGGHLAAAVAQEATDDASLPRLRLQVLLYPLLQLLDLNTPSYQQYRSDFGPNGGVVPRNIAGVFRSFLLFGRQDDAFVEAMMANNHTSLAFKKSNPHIYNHELVPKSLKQHASYKGPVVDTGNDELWSKHKYLFLDPRTSPGWRGDLSGMPQAYIMSCQYDGLRDDAVMYAARLEQAGVKVQLTNRYNGWHGMLNAQTFNVAQRALKHLIVYLKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH48</accession>
    <name>A0A913ZH48_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051113.1">
        <property type="nucleotide sequence ID" value="XM_038195185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195185.1">
        <property type="protein sequence ID" value="XP_038051113.1"/>
        <property type="gene ID" value="LOC119724229"/>
    </dbReference>
    <dbReference type="GeneID" id="119724229"/>
    <dbReference type="OMA" id="DIGGRCN"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042137" description="Collagen IV NC1 domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="549"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1260"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1759" mass="170634" checksum="F2FEE7EB6874B67C" modified="2023-02-22" version="1">MKYREVIERHVLVCCLLVLFVWAQWANAAACSGCLKDKCICNGTKGERGDRGYIGLPGHVGQPGFPGPEGPMGFKGSKGDTGSSGSVGSKGYRGSQGIPGFPGSPGLPGLPGPSGPIGEAGTPGCNGTKGETGSAGLPGTGPAGPQGQSGLMGSKGEPGEPAVNLPGNKGDRGTSGQPGTPGSSGVPGYDGQKGDRGPQGMTGERGPPGPQGPQGTPGVGFFGEKGDVGDTGPQGPPGEPCEDGTPSTGPGTGEILPGEKGDRGYPGPRGEKGMKGTKGYLGNPGLLGDDGMKGPKGEPGPTGRIGKRGKDGAPGQPGYKGDRGPNGVPGAEGYNGPQGPKGDKGDTGRRGLQGPPGAPADSTGEGAPGPMGPQGRDGPPGPPGPPGDKGSRGLQGVEGRPGNPGASGPQGQQGPPGIGEKGDQGPPGIPGPSGPVGATGVPGREGAKGDPGMTGLSVQGPPGMDGIPGRQGNLGPPGPPGDTGPQGQPGIPGSSEGKVGPRGPLGPSGPEGEPGQTGNPGPRGFQGRTGEAGEPCGQCPAGPRGMKGDPGPNGAPGRPGPQGFDGPQGTPGQQGQRGDPGVDGEPGLNGPIGPPGPFGEKGDTGEPGPIVPGPRGDKGDKGDRGYSGRFGEKGANGLPGPPCSAPSNISAMLKGEKGEPGFQGDPGVAGLPGRQGIRGERGASVVGNPGPPGPQGGRGEDGPRGPTGPRGDKGENIFISEPGQVGPRGPPGPPGPFGDLGERGPPGGPGARGTKGNRGFDGQKGEMGDQGPPGIGMPGESGEKGFRGTPGDPGPQGLPGSQGFPGEPGDDGSQGSKGDPGIAGIPGIQGPRGLKGGTGPPGAPGARGSTGQPGGNGEPGPDGPKGDKGDVGSPGPSGRPGEPGAIGDSIPGANGPPGEDGRIGEPGQVGEPGPQGPTGPPGFAAIKGQKGEAGRPGRPGDLGLPGPAGEPGEDGPSGLDGRPGEKGDRGLAGNPGQLGPPGEQGENGLSGSKGDKGSIGLPGVNGNPGPLGQKGDRGKDGLEGSKGEKGFPGPQGQSGLPGQNGQPGGPGPAGEDGPPGVDGPKGDRGLPGVDGLKGDTGGPGEPGPGGVPGLEGRRGLKGQMGDMGEPGQRGEKGQMGPEGTTGAPGREGLPGIPGAKGQPGLPGREGPSGAKGTPGPTGPGGPQGEKGHVMVVPCSLEMKGAQGPAGEKGDGGDPGPNGLNGLKGDRGLQGFTGPPGPPGENGAQGELGPKGQRGVPGESGSQGPAGPKGDSGRNGTPGSPGIIGLPGNPGIKGDLGPMGVPGQNGNPGADGEPGERGFSGIRGEKGTPGRAGEALVGPKGSTGVPGPQGRQGPPGSDGAPGEDGRQGALGMKGERGETGPRGPTPVPIPGPQGPPGDTGPIGQTGAKGDTGPTGAQGLPGRPGGRGTPGTNGEDGGSGEKGGDGLRGQKGEPAEPVNMALMKGTKGDIGPQGPRGSDGVPGQDGDRGANGPRGPKGDKGDEGPSGNPGFNGRPGAEGPKGNKGFPGSAGPQGFPGEPGLNGLPGPQVLTGYFITRHSQTSQVPACPFGTNLMWEGYSLLYVQGNERAHGQDLGSAGSCLRRFSTMPFMFCNINNICHVASRNDYSYWLSTPEPMPMNMAPFGGDVLEPFISRCAVCEAPAHVIAVHSQSLDIPVCPQGWRGMWIGYSFMMHTGAGAEGSGQALSSPGSCLEDFRSSPFIECHGDGRCNYYATTYSFWLTTVDSDEQFSSPASETLKAGALRTRISRCQVCMRDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI84</accession>
    <name>A0A913ZI84_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051497.1">
        <property type="nucleotide sequence ID" value="XM_038195569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195569.1">
        <property type="protein sequence ID" value="XP_038051497.1"/>
        <property type="gene ID" value="LOC119724490"/>
    </dbReference>
    <dbReference type="GeneID" id="119724490"/>
    <dbReference type="OMA" id="NENDISH"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="659" mass="72962" checksum="97778F37F51A9CB8" modified="2023-02-22" version="1">MTMILITVSSVYFTGVNNIDLADSMVLGHLIILILSSQVITSSAAPASQDASCNTTCGGLDANCVNQALTNVPLGCSPFIEMMDLRENNLKYLRPDSFMRYRHLVYLDLAHNKISNIAAGAFEGCVSLKKVYLQENLLTEVGEGTFEGASNLNGLFLNANKILRLLTAAFHGLDNLQYLDISDNDLQSLPLGIFDDLGQLKFLSLENNNLQSLQGSLFDGLVNLKKLILSRNDIVSITGFPSLPNLKTLDLFNNDLQDITDLADKINGLDHLYLGENHNIICMCSINSVRVWLQSHRSDEAANRVDVTCHAPQHLHGLQLHNISKYSLCPRSNFTPSLSTTENSPSKKLHVASTLMHVVNMGTMEPVSKTVTFTNHTKQKKTWDGHSKPHSIIMYVTVGTGALLIIIFFLILLNKCLGMLTRRNQQQNRNIIPDQQKAPQQEQSVPMMHITVNRFSQNDGANEVVQPRTPANDSAFGSQADLDVVTEMTQLRQDPIFQAVSTNSDDPFYMSIGDLNAPHCSPPPGLSKEDDLPPLEQEWPTTNPFLRDLTHNNQAYPSPGQYVPRATCTNASRNATPPMSQPVHQLSPMPPREPLQSVQAAPQDVTHYIPHCQMFQSTIPTQTQMLVQTPEHSLQHLNMSESTNPFKKATSKNPFTSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIR7</accession>
    <name>A0A913ZIR7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050940.1">
        <property type="nucleotide sequence ID" value="XM_038195012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195012.1">
        <property type="protein sequence ID" value="XP_038050940.1"/>
        <property type="gene ID" value="LOC119724103"/>
    </dbReference>
    <dbReference type="GeneID" id="119724103"/>
    <dbReference type="OMA" id="DENQGVN"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36415" checksum="DFD5A362939BA5A5" modified="2023-02-22" version="1">MNYQGTITEGEQFDREQDAMILHKAMSGIGTDDKAIIDVLASRSNAQRQHIRAYYKTAFGRELTEHLQSKLSCNYRRTVRALMDPPVEYYARCLYEAIKGLGTDEEALVEVLCTKDNEEIKEIKVHYKNAYKRDLEEDVAGDTSGHFRRLMLSMCSAGRDENRSVDQEKAKADAQAIFDAGEARWGTDEAVFNRILATQSYAQLRAIFDEYDKISDKGIEGAIISETSGDLQDGFLSLVKSVRDTQSFFAERLYKSMKGLGTNDEMLIRCVVSRAEIDLAKIKEIFLANYGQSLGQFIKDDTSGAYRDLLLRIVDGDTCHPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKP8</accession>
    <name>A0A913ZKP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051621.1">
        <property type="nucleotide sequence ID" value="XM_038195693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195693.1">
        <property type="protein sequence ID" value="XP_038051621.1"/>
        <property type="gene ID" value="LOC119724584"/>
    </dbReference>
    <dbReference type="GeneID" id="119724584"/>
    <dbReference type="CTD" id="6202"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000004">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000005">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="208" mass="24092" checksum="8FBE0E584BD84C3E" modified="2023-02-22" version="1">MGISRDRWHKRRKTGGRRKPLRKKRKFELGRPAANTKLGARRIHLVRCMGGNIKYRALRLEQGNYAWGSENVARKTRILDVVYNASNNELVRTKTLVKNAVVQVDSTPFRQWYEAHYALPLARKKGAKLTEAEEEVLNRKRSKKATKKYEERKKTAKLSQMLEDQFSTGRLLACITSRPGQCGRADGYILEGKELEFYLRKIKSKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMP9</accession>
    <name>A0A913ZMP9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052331.1">
        <property type="nucleotide sequence ID" value="XM_038196403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMP9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196403.1">
        <property type="protein sequence ID" value="XP_038052331.1"/>
        <property type="gene ID" value="LOC119725034"/>
    </dbReference>
    <dbReference type="GeneID" id="119725034"/>
    <dbReference type="OMA" id="YEAYDKF"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008336">
        <property type="term" value="F:gamma-butyrobetaine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="118"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45597" checksum="9A7B8E30900157EA" modified="2023-02-22" version="1">MASDSASRDPILKQLRRVDDEGWFVLEFDNGYTGRYPYVWMRDNCRCSACYHPSSWQRTSHVANLDPEVLASREEIRADGAVLAVDWSDGHRSEFQAEWLNRQRFAESVTDHVEGQELQTWGAEMSSEVARFDFQRLLVDEVERYKWLSQLFTKGIALVQGAPCQVGTIGQLAKSVAYLRTTCYGDTFQVFSKPSASSIAFTPKSLGLHIDLLFYEYCPGIQMLHCIQQAGEGGDSQFVDGLNIAEQLRRDHPAEYQLLRTLQIDFRDAGDDYINYHLKTRRPMIQYDRHGKFQAINYSDHCRSTELNIPVEDVKKLYKAIKVFNTVMYRPENVFRHRLAAGEIITFSNGRVMHGRSAFKLVGSQARHLEGGYFDWDEGKSAMRLLREKLYGEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN75</accession>
    <name>A0A913ZN75_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052819.1">
        <property type="nucleotide sequence ID" value="XM_038196891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196891.1">
        <property type="protein sequence ID" value="XP_038052819.1"/>
        <property type="gene ID" value="LOC119725484"/>
    </dbReference>
    <dbReference type="GeneID" id="119725484"/>
    <dbReference type="OMA" id="ASPYTWY"/>
    <dbReference type="OrthoDB" id="5948052at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="262"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="361"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="834" mass="89854" checksum="6D91AEC1A88F42C3" modified="2023-02-22" version="1">MGVDDDICPDGNLNSCGDETTSLETVKSRCQGMSTCTFTASNANFGGDPCNGIGKYLRANFQCKDQDPPSIVCPSNVNFYITNDESFASRPFPTNYNASDNSGSYDVMIYDTYPLGSVFQGPFTPGSLYNFSVSASPYTWYYVVSDAAGNEDNCTIQINAVLVDQDPPSIVCPSNVNFYINNDESFASQPFPTNYNASDNSGSYDVVIYDTYPLGSVFQGPFTPGSLYNFSVSASPYTWYYVVSDAAGNEDNCTIQINAVLVDQDPPSIVCPSNVNFYINNDESFASQPFPTNYNASDNSGSYDVMIYDTYPLGSVFQGPFTPGSLYNFSVSASPYTWYYVVSDAAGNEENCTIQINAVLVDQDPPSIVCPSNVNFYITNDESFASQPFPTNYNASDNSGSYDVMIYDTYPLGSVFQGPFTPGSLYSFSVSASPYTWYYVASDAAGNEDNCTIQINAVLVESTFSTNQPSSPYSTEVPQVSTESTIGESTFSTNQPSSPYSTEVPQVSTESAIGESTFSTNQPSSPYSTEVPQVSTESAIGESLSSTNQPFSTKLTEMPSSQSATTESSFSTNQPISTASTEMPQASSTELSLEDIRSTTHFSSSSEMSSRGFSTEPVTVGMEFSIQLRILDVDGEPAVFTTEHNDKNSLVFRALSAAVRIAILRSLQGSGRTSDVLEFEMTSVLNGSLVVNGVARFPLNSAVDSDIIRDVLHTNMMDNNGRVENSLLIDPLATVVTNPTEDCPAYHCQNNGSCEQQGSFPDYTYTCRCMEGLSSSLCEVSVSGEAGNGGVIAIVAIVGVLVLLVIFALVVACASLANQASKRNSRPSEYREQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP05</accession>
    <name>A0A913ZP05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053523.1">
        <property type="nucleotide sequence ID" value="XM_038197595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197595.1">
        <property type="protein sequence ID" value="XP_038053523.1"/>
        <property type="gene ID" value="LOC119725969"/>
    </dbReference>
    <dbReference type="GeneID" id="119725969"/>
    <dbReference type="OMA" id="SEFLMGP"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="171"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="598" mass="63313" checksum="516000F883359D4B" modified="2023-02-22" version="1">MSPVGNANISSKWTSVRRKIAAGCKDGKIRTYSDKTGEQLQVMSGPRFPVSHLFFDGETIVSAAAAKYHDKYHTTVDNDVFVSNAADGTCRCILKGGSTLLGVGRDRSWTAMELQTHENGNMEGTQKNANSQVPSPMETPPRGLATPEEAVDADGDQQPAKSRFTSHQIATIVGTILAAFTNMMAFSVITVFYPIEAKKRGISQTVIGMVFSVFSLSYGIGSLLIGKMIPIVGARFVFLAGSFFTGGCNILFGHRFIIDMPTIATFTGFSFAIRILEGLGSAAVLTASTAIVASVFPDDVGKAVSLVETTVGCSFAIGPAVGGLLYHAAGFRIPFFVLGGIVLSTVVVNCFLMPNQGSGNEAEESGSVSRVLSIPAVWIALFANFVGFAAYASLQPTLAIFLDELNFSVMAISLLFVSLGLGYGLFSVIWGAIADAKKCARTLIVVGASSSGGLFLLLGLPQILHLPVTGVLPGVTIPIAAATFSMLATPTFVDMLRSAEWYGIPSGLGLTAVISGLWNSAYALGSLTGPLLGGVITEYYGFGYSIMTIACTSFAVLIITCLFGIWEFRCGKGRREPREAFSSEDNSNDQEMRLLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRT6</accession>
    <name>A0A913ZRT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054483.1">
        <property type="nucleotide sequence ID" value="XM_038198555.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198555.1">
        <property type="protein sequence ID" value="XP_038054483.1"/>
        <property type="gene ID" value="LOC119726730"/>
    </dbReference>
    <dbReference type="GeneID" id="119726730"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="219"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="526"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="957"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1413"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1429" mass="157183" checksum="8C782D84073E016F" modified="2023-02-22" version="1">MTLCDSPNGAGYLENPDYSGDSCRDKICGRGDANLLRSCTDSHEWDNAMATDYPEGAISFISRFAVPAISQDSIHLTAVRVSWGQFDELYSPEITSNKRGALIFVNISTPVQNSVETFWVYPRLTTPETAEVTLQVPLPVRQGDNVAITVAYAEHRSNQCLDPLPIQSTCTDCLSVQYRTPAADCKVSDTCHQEYLSWKGDDPCVIVNHDTAIEEIVRPCLPLAEFQFVSPNQTAAEGESVSLFCLGTGLVQPVVEWYDVSDIVQVRGNGSAVLEVVVDSTPQSFQCFLDRYTAGAVTHETVTTVSSISDECQSLSAELRLFSTDEAGCFSLSQRMGIEGLDLDRIYISNSLTGWTTEVFIYQITVSSSVLRGQLVNRYGQDAVPIVVSVVLEMSPDYFLSQPRQTIEEYRRQYDLMYVPNDPETILTFDLTPPLQANSNFGWNVSFAVPDLRPSSEIIGGERIGQPPQAVALNCSDTTSVDCADLTAPWSNALQRYNQAGCNTARSYRSLHEAYRICRNISVAEPQIVVSPSSADVPVYGEGSSPGVTFDCYIENAVEYRWYKTAPAPSETFIRTGNQLVFQGVRENQDQGAYVCEGIPGKPYENKKVRTELATLTLTEVTTFKVTMKLLNRTYTEDLAVTDSEDFGNLQSELEQSFWSSVTRNLEQELGMRYNTEFEMLAFRNGSIIADVLVFFRRLEGNCGGPCTFGDLALQERLIVAIQERLQTSEFMVESETINVVNLVSCLQEVYLEGNLTFPQTRLGQTAQSLNLCPGFTTRAGKPRATRDCVGDFTSQPQWKQPVILNCFAGDVTENLDELAKMTVTSENAEEVAREMAFLTSNASAISPAAVTSVAEILEKLAVANNTSPEVAVQIIRTVNNVLQIDNETTLDEASRDNSPSRIVLALESFVTALHNSGAGNFTEVQSSVAVQALSLPRRALSNGLGFASSLGDPGTDDLTVNQTSVFTKEDPPMETEASIFLPAEILERISEAGDSDQVPISFFLYQNSRLFRSPTLNEATRPEDGVRRAVGSRVIAATVEGVKIDNLRMPVTNVFSLLNATSGNETVSSAECVFWDLTRNDGYGDWSTKGCRSESLPNGIIRCLCDHLTSFAVIVDIHGQQDSVFLDVISKIGCAVSVVALIITLVTYLYSKKLRTKRPRQILISLCFALLGLYLIFLVGIEATASRGGCTFVAVSIHYFTLASIAWMAVEATNMYLLFVRVLNANISHFLLVASIAAWGLPLVIVVIILAADYTQYEHQNYCFLKPGNAIYYGQILPIGLVLLFNFVIFTLVTRKLTCARKTIGTSSDKSQRQERLRRLQNAVAISVLLGLTWVFGLLSVIQAASFAFQVLFAICNSLQGLMIFVLFCARQKEVHQVWREMFPCKRDAHRRGLVSGTGLDSGTQGGLPLSSKGTKTTDFSEASQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT85</accession>
    <name>A0A913ZT85_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054649.1">
        <property type="nucleotide sequence ID" value="XM_038198721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198721.1">
        <property type="protein sequence ID" value="XP_038054649.1"/>
        <property type="gene ID" value="LOC119726869"/>
    </dbReference>
    <dbReference type="GeneID" id="119726869"/>
    <dbReference type="OMA" id="SAPMIGY"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="462" mass="51947" checksum="97304AE2BC547B4C" modified="2023-02-22" version="1">MASSVTVQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLHDVRQSQDPSGTKLTCPLCRRETMLKVSGVADLPNNFAFSALVEEVTMQEKLLEGQGSDIKCQNCDEENQAISRCADCDHFLCQECQKAHGRMTVMKSHKMYTLAELRSGEIVYKSKLRDEVPKCGKHPDQNLNVYCNTCEQVICLMCTVLDHEKPKHSFIGLPEAFEKCKKKIEELVAKVGKSKTELSTTIEETCISRKKLDIMFANTKKKISEKADQEVAKIRQEEQKLLKETDRIYQERVATFEAAQATNRKEVTQTEHKLEEVKQLMNNLIAVGYEGKKEISLHNPDGSLIRRLSAPMIGYYLTMYNHRLIYTTGMTKRLVCEDYYGASVFSVDMTSNKQGGWCPTVVCCDSDGSIYVAVYGHPPSNILHYSPDGKYIGCAIKGSGPLRGITFTPNGDLVVAVGHSVKVYHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZI7</accession>
    <name>A0A913ZZI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056745.1">
        <property type="nucleotide sequence ID" value="XM_038200817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200817.1">
        <property type="protein sequence ID" value="XP_038056745.1"/>
        <property type="gene ID" value="LOC119728537"/>
    </dbReference>
    <dbReference type="GeneID" id="119728537"/>
    <dbReference type="CTD" id="9847"/>
    <dbReference type="OMA" id="TMFYLES"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112826" checksum="78E2B9EBCB1F8CA9" modified="2023-02-22" version="1">MPGKLKVQIIAARDLPVMDRASDLADAFVEVKLGQVTHKTETCRKSLNPQWQSEWFKFEVDDEELQDEPLQLRIMDYDTYSAHDAIGKVYIDLNPLLLKDGASEIAGWLPIYDTMHGMRGEISVVVKVDLLENVSKFKESSCGVQFFSSSGIPTCYTVSAVHGFVEELVVNDDPEYQWIDMIRTPRASNEARQQLFTKLSGELQRKIGLKVLEREGNAVLGYWQCFDLEGESGIVVRGIGTAALIHRTNPLTSPLSTSPPQDQLNPKEFSVAEDTPDGTMIGSPLYTQQFSQPAPRSPSKVAPCRHLSDSDLTSAHLVGSQEKPGSGGSGGLTQRLSLLPKPTLPPITIDILEYPFFTIKKFPPGFLVHLGGVVTARSVKLLDRIHNPDEPETRDAWWTEIRTEIRSHAAAMGCHAVLGYKETTSICDEICLLSATGTAAIVNLAAFQYPVIPLSTQTQPNLLTTSLDRQDFQQQIQQNSQEKTPPQTDSVMSENPTAATESCPKCAICHIPYNESSLPFPVTVSKCAICKRSKVPDVLFNTVEPPPELPYTGRGCCIHASVCRSKKKATGESNAAMISDALPFMEYEIHRQLMNKLKVKGMNALFGLRVQIVVGETLLIGVATATAAYVTALPPPAPLRVTSQSGGGETQVQALQKLLLDTTAKNKDIYELHLPESLGETTALDSPQPILDNTDDLTDTQFLASQKDTYVLTVDDVEDKETVGGLFDPLLPTGLFSCTTETVPGNFRPSKHLQMFTMMRTQTLAETSTKHFAPIFDDLIQSMCFQLRSMAPCCLCSVCYDVNVPDDDVIQLWLTASAVDLRENATSSPEKVLQNKGIRSTDSELLFSMEELQVTEGVPASPSTPIGKGSKVPMLEKRIVLTDSTVAPVWRPKVEITPLSVVPGGVIDQYLGYINLFFVRESMSVRESGGVSGFMYNFISEVNAIIRSHVASLGGNALVAYNLVDCLVEDRNHQCQCLINVSGDAVHVVYDGSVSGMDSPCPGQLQMSHSQQFRRDSSTEASPQAVESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2B8</accession>
    <name>A0A914A2B8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057790.1">
        <property type="nucleotide sequence ID" value="XM_038201862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2B8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201862.1">
        <property type="protein sequence ID" value="XP_038057790.1"/>
        <property type="gene ID" value="LOC119729260"/>
    </dbReference>
    <dbReference type="GeneID" id="119729260"/>
    <dbReference type="OMA" id="QMRHSYP"/>
    <dbReference type="OrthoDB" id="10257972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000015">
        <property type="entry name" value="Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72467" checksum="F8DC8381A82B58A6" modified="2023-02-22" version="1">MGGAVSAGEDNDHLVDNLKEADYIKTERVEQVFRAVDRADYYLEGYKENAYKDLAWKHGNIHLSAPCIYSEVMEALQLEPGLSFLNIGSGTGYLSTMVGLVLGAHGINHGLEIHSDVIEYAKERLDIFIRDSGSFDQYEFCEPNFIEGNGLLLCSGCRTYDRVYCGAACPAEHENYMKVLLKVGGILVMPLEDQLKKIIRTSQAEWETKNVLPVSFAPLILPSKTEGESFSSIELPEVHPKSLQDLCRIKIRGIIRAIVDVEHPPSKNNKRQPQRPPHHRSMGSVNSCIMIRNVSNMLELAGELMSSDNYDDSDEILEEEEEEDEAEDDEEGRGDGDRERMEEGGEDWKKQDFEMDGPEAGSSDKDGARDHKEEGKRNGRRGHRNGRQRHPGFNPPSSRPGRFMMEFSQRPDRHGEENPSGGARARSEEHSARGAVEMCLSEAFEFARNLKRAYDNGAPRDRKRMNDRHSEGDSSKETADAAAEDLLLHEGKDSKPHLSSSPVDDSLTANGSTRDESDDTTRDFTKQPDSISTPPETEEDAGKSKSSKPPALPPADARPPQMRHSYPFRSRDQAPGEDSGNSSDSSHSSSSGISDETIYDHLKRKKRLAKQKAAAAAAAKPVGPNYLREKILKLPLPQSLMSYLLYHREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5G4</accession>
    <name>A0A914A5G4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059097.1">
        <property type="nucleotide sequence ID" value="XM_038203169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5G4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203169.1">
        <property type="protein sequence ID" value="XP_038059097.1"/>
        <property type="gene ID" value="LOC119730329"/>
    </dbReference>
    <dbReference type="GeneID" id="119730329"/>
    <dbReference type="OMA" id="NDWPIDS"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="143" mass="15759" checksum="76DB423CC04AE19B" modified="2023-02-22" version="1">MEDMTIADGQIRASSSTANAPAIEARLNNMNGKWNPKSTDANPWIEVDLEKSTVVYGIITQGGLIDWYVKKYTVAYQKQPSTVYDHVSDGNGDIKVFVANTNIHSPVTNLFDESVVVMVVRIEPTSWSGGVGLRLELLGCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5K1</accession>
    <name>A0A914A5K1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058686.1">
        <property type="nucleotide sequence ID" value="XM_038202758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5K1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202758.1">
        <property type="protein sequence ID" value="XP_038058686.1"/>
        <property type="gene ID" value="LOC119729965"/>
    </dbReference>
    <dbReference type="GeneID" id="119729965"/>
    <dbReference type="OMA" id="MSTQTCE"/>
    <dbReference type="OrthoDB" id="10636191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1112" mass="118239" checksum="B61B66C38B6C7E31" modified="2023-02-22" version="1">MGCPQSRKRKRRARESGKEHQQLSKSALKKQKKAKAKMAKALADTKAKGDAELRAVALAVAGLGGVQLPAITSKQTPEQTPEQTPEQTPEQTPEQTTTIPEQSLTDDEHTTPEGILKTKKEIKSPKGMMTTDSSVAAAITDAVAKVISDDAVSKSEDLKAILGLTQATLATERPTSSASIGPRLIVVNEADICIDNTAEKPSNATPKPEALIKEPTIADNEHAAFVAPVSVKGDIKIKGEDDKANDQIDDSSSNLTLEAANLVEAVFANLDKDELNAPQPEVLDSAADEIAAAEQAAILEQEAAYLVDAVFDSLDREDEDDDGTSTLATDVPMDVEASFNLADDAAEIVNAVLARVTADLQYEGQTAGTDIQTVDMATDTVQQTPRSLDLEAAKLVDACLTSITEEEMEMQTASTTTAVEVQPRDDLKEESKQCNLDQQAAEMVGAVLASIATEDKITTLSKVTSTATDVTSSTASVDAAELTRIILSGLKKSSINLPRPTSEMSTQTCEMSIQTDDIMSEEASPSKKPSAVSKIKSAIKSASKKSRTALLGKKDKQNEDKKSSGIGKNIKCDKASGKGKTKLADSKKPARDVKKSTSRRKKSPTVDRKKSTTDELKARNASSRMLKLKEAANGTSSSSTATSSKGKQIATKKSEASKNVKKSTTAAGSTTKGKAKPAEKLKASKSSSSPRKGGKHKSPNNSVSANTAKNKESSLSANNLPDEKQQPKTASVTNKATKARDNSTMKSKSSRNLKPGRVSFQAPQDVASSPTAHRKVMQASTVESKDGYIALTSTDCPRSSKMSTKHQKHLRKGVKSISSEGPPRRANSAQRAHGPKTSLAMLADARPSTVLATQMESATIAEQLRFQGSDGSAMGDNIEVIRENSVTHQLSLEDQPLDQLQQDAVAAVNFNNQEHQQQDQVQIQLTHGNDTNAVGYSTVQSSTVSPVAVEGDGCAHSITQPRSRPSTGKITPVSSAHLLAAKKPSSSILDCSRIQSRRPHSSESRVRDTPEIPNKNDILDSGSPRGRSPLRRASKTPTPTKMPSKKPSSDILCSPGHLIRDAASAVEKQRRMKSRSTTPSATPGHLTPVGGGGESPRQETAEVQLGCTQRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5Q5</accession>
    <name>A0A914A5Q5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058741.1">
        <property type="nucleotide sequence ID" value="XM_038202813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5Q5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202813.1">
        <property type="protein sequence ID" value="XP_038058741.1"/>
        <property type="gene ID" value="LOC119730022"/>
    </dbReference>
    <dbReference type="GeneID" id="119730022"/>
    <dbReference type="OMA" id="SSTNELW"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27661" checksum="9E9B80F67CCB56E0" modified="2023-02-22" version="1">MCELSLATRREHPEDFNATQGSVYFDADEDTSRYSLTDSPLDRYRSCKMLLDAGYRSSCIYTIYPEGFSDGGLRVYCDMETDGGGWIVFQRRQDGSVDFYRNWTEYQSGFGDLSGEFWLGNDNLVTLTSDDSRGTWELRVDLEDREGNTAWAKYADFQISLGEYNLNIGQYDASSTAGDSLAYHSGRPFSTNDRDNDAWGSNCAQSRHGAWWFVMCSRSHLNGRFTKLGAVEITCIGTTGKAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A611</accession>
    <name>A0A914A611_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059302.1">
        <property type="nucleotide sequence ID" value="XM_038203374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A611"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203374.1">
        <property type="protein sequence ID" value="XP_038059302.1"/>
        <property type="gene ID" value="LOC119730457"/>
    </dbReference>
    <dbReference type="GeneID" id="119730457"/>
    <dbReference type="OMA" id="PLMIHHT"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF4">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="40"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="249" mass="28683" checksum="3899134FA3AF9959" modified="2023-02-22" version="1">MSALLPPAVVAGSALTLQAFNRALDRLPRRYGPCGRYSNTDKHKWRNAATSLLNSFVLSVLVLSCFYWYPELWDDMANYSMQLGEITYTALFGYYMYDFYDMVIYNKFSAIWPVLGHHLTGMLLLGMLHAYKQAMSVILVALLCEISAVFLHLRQLLLMHGVPRQSILFRVVKVVNLATFVIFRLIPIVFSFYCTLTYDLAAILAVITRLCNFALIVVNVVLFRRVVYSDFIRRDNNNKNEDEAFIMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7A3</accession>
    <name>A0A914A7A3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059301.1">
        <property type="nucleotide sequence ID" value="XM_038203373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7A3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203373.1">
        <property type="protein sequence ID" value="XP_038059301.1"/>
        <property type="gene ID" value="LOC119730456"/>
    </dbReference>
    <dbReference type="GeneID" id="119730456"/>
    <dbReference type="OMA" id="CCMSMFN"/>
    <dbReference type="OrthoDB" id="10072151at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037549575" evidence="2">
        <location>
            <begin position="25"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="559" mass="63910" checksum="C8B49CF464EDBE03" modified="2023-02-22" version="1">MPHHNARFLVILLLFLLQPLPSRTAATPKPRSETFWRKFCGFFCPYQLSCDSDVYLSSQQQLELLNSQEFLDILELFPQILLENEKLQHTTLVRLEDHQRDLILLRYKDFFHPRETLPLARQRVVSQLAKDQQGFQGDPVAEPLPNEIHLTVDQVQQLLEKNAHLKDNQVHDEVLPEDEVVGTPNWDEAESFIRDYVNKQRIQQSEKKETHLPDVTSQIPSNRVSGKKAAHKTPSKKDKPIALNINQLQDHAEHLNVEQILKELEKMGHSFDLNNLVSDQDRDSSEAQYSQPEPHRTTDSDPTVLQQVPTKTGDSNHNSSRKKSAHRKGPHAKHVNRITDKKSKNSKEPYSDSHDARTLEEHFYSHQQTNLPSKQQIAQALEFLNSPPSSAQYSSVQSRTGKKRTSSSESNSGHRRRVGQKRPSGFVYEPGGSGEEGGTDEGDRESQEVSKRHSRRKREVLSMQVCPVVETWSNIVLAETVNGTLVQIAQFPEVNLEQWFLEERCLYKESQIINGVTCEIRERLVDAVVIPVVNPSQPIQRAQIKVDCCMSMFNVDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8C1</accession>
    <name>A0A914A8C1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059669.1">
        <property type="nucleotide sequence ID" value="XM_038203741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8C1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203741.1">
        <property type="protein sequence ID" value="XP_038059669.1"/>
        <property type="gene ID" value="LOC119730724"/>
    </dbReference>
    <dbReference type="GeneID" id="119730724"/>
    <dbReference type="OMA" id="HKGRTHI"/>
    <dbReference type="OrthoDB" id="6769862at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="521"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="81974" checksum="8FFA2AF9CAB9BF69" modified="2023-02-22" version="1">MCDKYSSGNQSPSRFGFHYQHREIHSCPYSEFNIPWFSYRLFIHDSLSEPGEDRKDNQPLPRDFGGANCHSSTTLKPHRQVIVHNSGSFSSPDLLPQSSGGQNLRPPQGEQLRISCHPFTSFPGGAANMGAMSACMERSAFSSSDARFDPSNGRFYVGMGSLSSLHDRRPLDNSRTTTSYQLPRTVSSLVCHPISPRREAGHPCSSSDGQFNSHCIYQPPRRDSLGSNVSTSCQDLGMVSQEKHHSSSSTYTGVPEHHSRQDVTSVRRSGGMATPPRSLPQHHGCPTFCPIGRPLCVSPEYTTRNVRFMAARPHGLEGQCSSSKLEGCKRLRFSSVFTSSENPSKDPQRGSYSCSCRSSMEDSSLVPHAAGTSNRRATAPPTENRSPSASPQLVTSSSTDRPPPTGRMEVIRANLSSEGLSQTVSATILASWRPQSNAQYNSAWRRWASWCLQRKLDPVHTPVADFLEFLQQLFDEGLSYRTINGYRSAISSAHCLIDNLPMGQHRLVKRFFKGIFGLRPPRPKYNSTWDVGKVLRFIKSLPDNRRLSLRQLTLKLAMLLALVTASRRASLTAIDVDNMTRSSDGKYRFLLVKPSKCVSVSKPFHQIEISKFQPVRNLCPVRSLEEYLQRTRHHRGTGSSRMTQLFLSHSKPFHPVVPSTISRWLKDLMSQSGIDTSQFQAHSTRSASTSAAARAGVSTSEILKTADWSSASTFANFYHRHLPLSDFGGAVLSSATQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9I7</accession>
    <name>A0A914A9I7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060418.1">
        <property type="nucleotide sequence ID" value="XM_038204490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9I7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204490.1">
        <property type="protein sequence ID" value="XP_038060418.1"/>
        <property type="gene ID" value="LOC119731329"/>
    </dbReference>
    <dbReference type="GeneID" id="119731329"/>
    <dbReference type="OMA" id="YLCALTI"/>
    <dbReference type="OrthoDB" id="10061436at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="395" mass="44527" checksum="904ACCC006B03128" modified="2023-02-22" version="1">MPTRSEREYILAPDESCYKSPDFKMAERHSDHCSRKQSTLNRQVDDRMFSETVADHRTGHPSPKPGVLGTGVFSLLTILVEVAKQTIVFAVRHFNTTKLYPFYIGSIVFCTELSKFLFCYLIFCVQHRRMRFMPSPVFVFPAFFLVAANSAFLYCVYYIAPPTWNIFLQSRAVFTALGGFVVFGRPIERRTWVAMVLLVVTAMLAVLFSPGVVTSQYYPYEEDTKMWVFAAFIGVACSAFLYDSFEYISKLGKRPIAEKHIQLYFFSTVLGFIGAEFTSNGNIFELDIRMFFPLDFYMCVLTLVVWGFGGLGLFILMNRLSTPADEANFIPAWIPPVLFLLSTVVSSLMFPTQQGYSHGVTAVIFLLMGTVSVLYSSGGSSTVPPEQNKVAIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9U8</accession>
    <name>A0A914A9U8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060182.1">
        <property type="nucleotide sequence ID" value="XM_038204254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060183.1">
        <property type="nucleotide sequence ID" value="XM_038204255.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060184.1">
        <property type="nucleotide sequence ID" value="XM_038204256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9U8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204254.1">
        <property type="protein sequence ID" value="XP_038060182.1"/>
        <property type="gene ID" value="LOC119731189"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204255.1">
        <property type="protein sequence ID" value="XP_038060183.1"/>
        <property type="gene ID" value="LOC119731189"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204256.1">
        <property type="protein sequence ID" value="XP_038060184.1"/>
        <property type="gene ID" value="LOC119731189"/>
    </dbReference>
    <dbReference type="GeneID" id="119731189"/>
    <dbReference type="OMA" id="HFGANNG"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000031">
        <property type="entry name" value="Homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43144" checksum="06A558B8CECAE4BC" modified="2023-02-22" version="1">MFKFDNRRAFSDILPSFNHFGAPNGGQHPTSSPVSTNGSDLLNMDANGLQQQQQQPVPHNGHVSPGMLVQTDSNGYGIATTPHRVLEKSGAPPSGLIDTSSTDRHQPRMTELCPVGASTAGSRAMVDLVMDDVEVKGRKIARNDINGETNVENGNTSATEENSSENEASKKRRQRRQRTHFTSQQLQELEGNFARNRYPDMSTREEIAAWTNLTESRVRVWFKNRRAKWRKRERNQLNELKNGFGSQFNGLMQPFDDGLYSGYSYNNWAAKSANPLGSKGFPWSLNTVNPLAGVSNQPMCFNPQTTMSSGFPSPNVNGVMSHQNLNNSAGAAAAACPYASVPASSYMYREPCSSSIATLRLKAKQHSGMGTFSYPVRQSPTLSACQYAGLNGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9Y0</accession>
    <name>A0A914A9Y0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060214.1">
        <property type="nucleotide sequence ID" value="XM_038204286.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060215.1">
        <property type="nucleotide sequence ID" value="XM_038204287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204286.1">
        <property type="protein sequence ID" value="XP_038060214.1"/>
        <property type="gene ID" value="LOC119731209"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204287.1">
        <property type="protein sequence ID" value="XP_038060215.1"/>
        <property type="gene ID" value="LOC119731209"/>
    </dbReference>
    <dbReference type="GeneID" id="119731209"/>
    <dbReference type="OMA" id="RFKLICW"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="616" mass="68343" checksum="C5C7C608821B8091" modified="2023-02-22" version="1">MVLNPKKKQESIPLVTKETPSINHGGTDSSSVDSSPEHHAPNSNPHASESHAHWESDHPLHRRAYTQILIFQSLISVAFLAVQENIVLYCTEVLFYVDGGAPKMIEVYAALVPCLPVFGGLLADIYAGRYKMIKIGAFTTLAGLLLLTFDIIPFENWFARSISIEAKRGIFIFGFTVMFLGFAGYGANVGPFAARQVEQAGEKAVRTLFHWFYWSTTLGLAIALPIADYVDRVINFGVGFAILTVSLVIGIVVLMCLGSDYVEVQPQRDALFRVFKIIYQGIRNRVISSQQEERETDSSRERPDGTLDYAKQEHGGSYCRLNVDQVKHLLKTLPAFHTVTIYAIVYYFMTIIYYEQFKRLNPYLGDIGESVHLPNVTFELYSTGVVLLFTPIFCYLYPWLEKKGVKVTPLRRIGVGVFFCLLSVLSACLVEVHRKVVMADGGTFPNPVGNTTYEASTLSCFTLVPQFTFGGLAQAFVRVAGLEFAYLEGPDNLKGFSTGLYILMSGVGSYILAKILILLINAMSYASPWYTSEINDGHMQYFFLVLVGVQLFDLIYLGLICRKYEYAHWRERAVREGAFPDVVPGNDPVTSGYAVVPDTSASDTDGSPARGAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAA9</accession>
    <name>A0A914AAA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060703.1">
        <property type="nucleotide sequence ID" value="XM_038204775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204775.1">
        <property type="protein sequence ID" value="XP_038060703.1"/>
        <property type="gene ID" value="LOC119731585"/>
    </dbReference>
    <dbReference type="GeneID" id="119731585"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13244">
        <property type="entry name" value="PH_PLEKHG5_G6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040181">
        <property type="entry name" value="PKHG5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217:SF11">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13217">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="417"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118167" checksum="A16A8E32518F7C18" modified="2023-02-22" version="1">MDQVPQITVSESTHPMDKTDTVHISFEEGQQPPSNDMDADLHDNARSSFISSSSGTSGTSDESINYRDSVISYTSIDSMDRQSIASEAGGLSRINSTRSMPPERTHNDSDGSEDGHMLIKNVVRKTLTRKTAIRRTHTLTPNSSPKVKDRRNRSISSSDSPLAELQKRGAVKEFITVYFELRFYTQTHEIQTTRDLLLRDAIKPILATAEIDLRGIDIFIESSTSPTPLDFPTYPLSGRHLHVRAKAGKNSKAVISPSFAQKTMEDGEEKEDSGEPFIATIPMRKDMSKFLGVEQKEIQPTPRQSTQTLERKKDLTKLLGINQPDPIPNSKGNRRTSVATGQPVTIKDPAKEKVDPKFLKLKQTLDDFMINGLPDFPALLTFTTKREDDEECFQFEESWRAMGDEETVSQLTKKQTDQQEAIWEIIKTEVGYIKNIRIMVDFYLCTLINLQASAMLNQIETEKIFSNISAIEKLHTRFWKEKLSNVVTKARAEKRIPSATDLAEAFEGFADLFAPYIKFCTDEHECMKYLRERTKDNEMLRFFIEWAERHPNSQRRKLQDLLVYPMQRITKYPLLLIAVEKKTLEEGENAVVSTRISEVKEFVMRVNHELRQEQERQTMEDTIDHIESFEAVSVPSGCEELAKLVDEHATLDLLGSMPNAPPAQARWLHMKGAFKMRDADNRFDAYGFLFTDMFVLAKPKKGENYKIIKPPMRVDMIRTQELKDGSGFALVHVDEYNCAVYGCVLSAANTQEWLHKMETARELYENMCSFELNYHNRKEVDDGSGEPPTSPEAMVFSMQNTAFPLIVDNNSPYSSPLNSPRLKDRRMLSPLSMSIQGGSQSSLNTAGGVSPVPEEDTEEGEEGKDDASSEVHQVSSPGAAEVGIDGGSPADKLNSLSDQGRSTFPPSKRQSQNGDKVQNSVPTVASGETNGGSPTKTQTKSNQRRPANLTLPPTHPQPTSPVSPNNTTIMAFESDDDEPSEPMCPMPLSVAPSSPRKISLQQPPMYPVNKSPNRTRRKTTTALGNNKKQNGEETKSKGKFSKLLNKKKSAPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAS9</accession>
    <name>A0A914AAS9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060868.1">
        <property type="nucleotide sequence ID" value="XM_038204940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAS9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204940.1">
        <property type="protein sequence ID" value="XP_038060868.1"/>
        <property type="gene ID" value="LOC119731716"/>
    </dbReference>
    <dbReference type="GeneID" id="119731716"/>
    <dbReference type="OMA" id="TIHYSEN"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="370" mass="42233" checksum="C8680699E4BCB8E6" modified="2023-02-22" version="1">MMFTNKARMTTLLVICVLTMVFYIGVHQGRVSEYVKIALGYINDDVNPPDVMTRNGTLFERQPVQQIGTGIAKIDAEEETVHERSDVVGVGGTMIDLETAEPKELMNRMVIVTATSQNHLKESKGMIGSVQEFLPNTRIVMYDLGLTPSGIKEVRRLCNVELRPFDFSRYPSHVRNLLKFAWKPLIIQEALNEFGIVFWCDASARFKRNPLVLFSLLKEQHGFMSEVVQYKPDYMLIRTHPKMFEALGIDREKFKKDDGYAMCIEANRLLFVNSALVRRNIIEPWVDCALRPACIAPNGSVIRQFMAGPKLYTHRFDEAALALIIYKNLRGVFKEQNDRSELFHDVVKLSRSSQGYEKAKVCKSLATILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABR3</accession>
    <name>A0A914ABR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060794.1">
        <property type="nucleotide sequence ID" value="XM_038204866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204866.1">
        <property type="protein sequence ID" value="XP_038060794.1"/>
        <property type="gene ID" value="LOC119731661"/>
    </dbReference>
    <dbReference type="GeneID" id="119731661"/>
    <dbReference type="CTD" id="340146"/>
    <dbReference type="OMA" id="GWKDPTM"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="346" mass="36994" checksum="5BBF763BC8BFD971" modified="2023-02-22" version="1">MTTVPGQSARWSGVSAAVFYGVLSGSMSFVNKVVLSTLGFHFPCFIMLCQMILTASVFKCLGILGHLCLPPATFTNLKLCWLPSILGLFHSVLSLHALGGMNVAMYTILKRCVPLMNLLLTPCLLQKGAPSLPVVGSVMVMTAGCVFTGLGDLTFDLTAYTFGMLSVFSQSLYLTLVQSLSSQHETLSAADIAYLNSLNCIPLLLLYTTATSEFTQILDFPDLHSIKFLVAFLVVISMGCALNYSVFLCTTLTSALTLSVVGVMKSVVVVIVGLFTFGGVQLSVLGGMGVTLNTLGSGWYTYAKYQEKIGSVKMEVESATQELVSEFTMGNGHLTNNQALTGIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC09</accession>
    <name>A0A914AC09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061006.1">
        <property type="nucleotide sequence ID" value="XM_038205078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205078.1">
        <property type="protein sequence ID" value="XP_038061006.1"/>
        <property type="gene ID" value="LOC119731806"/>
    </dbReference>
    <dbReference type="GeneID" id="119731806"/>
    <dbReference type="OMA" id="IPSDPWK"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49943" checksum="AD6F22FA67D1F408" modified="2023-02-22" version="1">MPSYKLYYFDGRGWGETSRLLFAVRGCEFEDVQLEYGGDQTKWKELKPKTPLGQIPVLDVDGKQLPQSRAIEGYLAREFGLYGSNSLEAARIDAVYDTVRELIARPTKLIFYENDEEKKKAELAKYYAEEAPRRMGGLTRLFEMYGGGEEGFFVGNKMSLADIFFFAMMEYFDENELKKYPKMEALHNRVATNSRIATHMKNRPAYTFKAFLSTRLFDCRLNRTRTSFAPVESKMPSFKVVYFDARGRAEPTRMMLAHVGQAFEDVRYKGEEWAKVKAETPLQQLPLMEVDGKPIPQSRAMHGFVARHFGLNGANNEETTKIDIVLAITEDLVDPLAKILFQEKDEAKKKEKMAAYLKDTAPRFLKGLEDILKHNGGGDGFFVGSKISRADIVYLVATEAFNNDEVLKQYPKLYALKGRVAQDANIAAYLAKRPKTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD33</accession>
    <name>A0A914AD33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061381.1">
        <property type="nucleotide sequence ID" value="XM_038205453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205453.1">
        <property type="protein sequence ID" value="XP_038061381.1"/>
        <property type="gene ID" value="LOC119732078"/>
    </dbReference>
    <dbReference type="GeneID" id="119732078"/>
    <dbReference type="OrthoDB" id="10664001at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038138439" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18074" checksum="40A11BD64A4FB94D" modified="2023-02-22" version="1">MLNKMAVVSYCLVGVLLLTALVSGQGDLLASEPQLELLNGKVKIVTDVFRPLVDSMTKNPFLCTACENFVQFLRNAADNQQLLAELVTLILPVCDWLPSAMHEECLGAVRKMPTLLKMYTYVYLDPKTDCALLCAASRMANAPNLVPLTVNDLVQMMNKKPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADS1</accession>
    <name>A0A914ADS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Follistatin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061883.1">
        <property type="nucleotide sequence ID" value="XM_038205955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205955.1">
        <property type="protein sequence ID" value="XP_038061883.1"/>
        <property type="gene ID" value="LOC119732438"/>
    </dbReference>
    <dbReference type="GeneID" id="119732438"/>
    <dbReference type="OMA" id="IHAGNYT"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF81">
        <property type="entry name" value="KAZAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="8">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="428"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="103491" checksum="06BC829853A4228F" modified="2023-02-22" version="1">MVFGRSDYQQDIIMRAVAISLAVLFAAMCMVDARPKGHKRHHHGDDDYKDDQVNPCNFMVCPKGSECTFNSSLADPICVCIRECKPHQRPVCGSDGVLYDNHCELHRAACVKRTRIAVVPDAVCEKPTTAPELIGGNPEVFGDQKPDTHDEIVDQHIDETIEDEEDDAAAADDDADDDEKDDPEVDEEEPEVAEEKPEVVENDTEMVEEEPVVDTEKPVLEEIPTEVVCSEEGLAEFKTNLLDHYRTQFNNPRDDPVLPELDKKFLVSLMTNHFDSSRDSLLTGDEISSVISRDNIEGLSAQCSLLDVLRIYDKNGDKKLDPYEMYDAFDVQIVTISEDLRQQVKVATAGDNVVLVCRIEVEDKSNVIWQRNGVDLIDVQLMDGMKTYDDGTLYFNKLTLMHMGIYTCYVEGYRSVKQTYTVEVRVPPSVHTCPQSRFQSKGKTAKVQCYAQGVPEPEKLWSKKGLTLSDRPGLRLEDCNTTVCIESLDYPDTGKYLCRASNPVGSVQSVSSVFIQENTKALDLGPMHVYYLFHSDGVRVIEPDTCGYRLNIPALHVLPKPHGLLCPPGPSGEIACSWGEAVNVKNQFVYVTQPENNRIIAIDVRTQLIIEVIPTDRIPVSLHYIPHLDTLWVVCWQSTDAEEGQRSIQVIKYVSQRETHTPIHTTPIGHHFDVVKGLFIPQVQIPNQGNYKFGYVVHSQQMAITKINLETTTLSSTIVLSQHQCYPDSVAFLATGGYVIVSCADGRESRPSKQLFLDYLTDTVLHVNEGIRGTPYTSPDGRYIISADNQHGLIYVQKVTLSGKVKSLFEVSTNLGVSDVGFFPTKASTHTYDIMVTSRDRPDVLFVDLETSKVKMIPGVFHPISAESWPWNEHNRHIVNSGVFGPHLATPAADHVVLIDGKKKSVQCDIDDVSQSNVIVWVGDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADY8</accession>
    <name>A0A914ADY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061701.1">
        <property type="nucleotide sequence ID" value="XM_038205773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205773.1">
        <property type="protein sequence ID" value="XP_038061701.1"/>
        <property type="gene ID" value="LOC119732311"/>
    </dbReference>
    <dbReference type="GeneID" id="119732311"/>
    <dbReference type="OMA" id="HSWNGSI"/>
    <dbReference type="OrthoDB" id="6262482at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036849884" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="72"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="222" mass="24004" checksum="61FD0F7B6BBCEAF8" modified="2023-02-22" version="1">MDGAVAWILMASAVAVFLVGVESKARVCYFGPPPEPDPENPDGWMKQVMQEVRARCPGQGRRQPTTAGTAACSSPEPLGMEDRTIPDDRIKASSSLLCCPANNSRLNGDTAWVALDSEALNSWIGVNLVKRTVVSGITTQGHHYGDHTTKYKVAYKERPSSAYEYVTDGNGDIKVFIGNTDGSSPVTNMFNENVVATVVRIEPTAIYVHAALRFELLGCRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIF0</accession>
    <name>A0A914AIF0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063174.1">
        <property type="nucleotide sequence ID" value="XM_038207246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207246.1">
        <property type="protein sequence ID" value="XP_038063174.1"/>
        <property type="gene ID" value="LOC119733880"/>
    </dbReference>
    <dbReference type="GeneID" id="119733880"/>
    <dbReference type="OMA" id="ISHPAAW"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586138" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="132"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="26751" checksum="AED939C5FAB5C54D" modified="2023-02-22" version="1">MKICVATVLSIALLLGNSVNLRASVTGPVASDGDGPASQACPMCCQGPAAIPGIPGLPGSLGQPGSKGEPGQKGDIGQSGPMGERGAAGPQGDEGIGQPGKIGPRGVPGVVGPTGETGVKGQKGEPGEAPDDSNQRVAFTVVRTSSSDASTSHDTRLPFQATKTLLPGTSFDLETGTFTCGVPGTYVFMFSVCKYPSSSDLYVYLRKNGDAVVSGHSTDSSHHEQVSGSAVVVLQRGDTTYLTMSGRALGGSWTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIJ2</accession>
    <name>A0A914AIJ2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063547.1">
        <property type="nucleotide sequence ID" value="XM_038207619.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207619.1">
        <property type="protein sequence ID" value="XP_038063547.1"/>
        <property type="gene ID" value="LOC119734244"/>
    </dbReference>
    <dbReference type="GeneID" id="119734244"/>
    <dbReference type="OMA" id="VAWERAM"/>
    <dbReference type="OrthoDB" id="10006908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07168">
        <property type="entry name" value="NR_DBD_DHR4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="255"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="427"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="680" mass="75941" checksum="4D6E6A24461613AF" modified="2023-02-22" version="1">MRETTEPVQRRHSMKRCSVDIEFPNGTCLDSKSPKMDIICNNNNNNEPVFKKLPPTKRWSGLYKGGEERLAMSPLSKSPGRDEVFICEDSVMDGITMHCRPPLPPPPLLMVSNLIPPSPCQTIACTTSDSGFLLKTKRPSLGGMDSPMCAISPFSVLSSPSCQPSPSPSLPTPGAFLPPSLPSGNFLFPPFTAGIPFSSAASSRFPFPPQLPFHQAPQFLREGELKLRSQSESAVSGLDSQGHSEESNSDEDDSLMLCSICCDKATGLHYGIITCEGCKGFFKRTVQNKRVYTCVGSGNCEVTKAQRNRCQFCRFQKCLQMGMMLEAVREDRMPGGRNTGLSYKCKPKNYDKLRKKFQQIAQQKAQLSRKNRADKQALKAARETLKSEKDQKSKTLTQSPSENSNSSSSSNSGGGRDKHQSQLDVRQLRPQTAQLIEVLQQTESAVLKMSTKENTGKNGHPPTXAPNPGLPGLDEFTHQQCSLGDSLVFNLVQWVKHLPFFTQLSPVEHTYMLKTKWVELLILCTVARAMYFKQNSGEKVLGFEHCVHQNLLTLQECMNKTMDLKLDMGVFREEMGEAVEELTRLAASFRTLNISRNEYLLLKVIVLLNLKNGASNDLVRQVQHPYVLALRDFVEVNHHKSRFEELMSQLPELRKCSELLCKCKLLYMPYLLNAVAMAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJQ8</accession>
    <name>A0A914AJQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063791.1">
        <property type="nucleotide sequence ID" value="XM_038207863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207863.1">
        <property type="protein sequence ID" value="XP_038063791.1"/>
        <property type="gene ID" value="LOC119734370"/>
    </dbReference>
    <dbReference type="GeneID" id="119734370"/>
    <dbReference type="CTD" id="10211"/>
    <dbReference type="OMA" id="AFQIQDI"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="86"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="427" mass="47615" checksum="536043B57D6C5240" modified="2023-02-22" version="1">MVFFEVCGPNEAMVVSGCCHSKPLLVSGGRTFVWPWIQQIQKLSLNTMTLKIDTDNVYTRLGVPISVTGIAQVKVQGQNKDMLLQACQQFLGKTEHEVEMVAMETLEGHQRAIMGTMTVEEIYKDRKKFAKNVFEVASSDLVNMGISVVSYTLKDVRDENGYLKALGLARTAEVHRDARIGEAEAKRDSGIKEARAEEERMAARYANDVEIAKAKRDFELKKAAYDMEVQTKKADSELAYDLQAAKTKQRIKEEQMQIRVVERTQQIQVQEQEISRREKELKAQVKQPAEAERYRLETLADANMKRVVMEAEATAEAIQLKGEAEAFAIEEKAKAEAEQMAKKADAWKDYQDAAMVDMVLETLPKIAAEVAAPLAQVNKITMVSSGKGDVGASKLTGEVMDIMNRVPQLVENMTGVNISEAITATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AML3</accession>
    <name>A0A914AML3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064833.1">
        <property type="nucleotide sequence ID" value="XM_038208905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AML3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208905.1">
        <property type="protein sequence ID" value="XP_038064833.1"/>
        <property type="gene ID" value="LOC119735201"/>
    </dbReference>
    <dbReference type="GeneID" id="119735201"/>
    <dbReference type="OMA" id="LICEHER"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="92"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="36135" checksum="68795D0E7FEE974D" modified="2023-02-22" version="1">MGHLAIPRDRLSNFRELGHGEFGKVMLAEARGITQGSEVTVAVKTLPDEPPINGKKDLMRELDLMTTLPYNPYVVRLLGFSVEEDPPYIILEYLSRGDLKTLLIESRSKGAHAYDNLHGDSTSLTAKQLMHFARDVADGMKFVSSQLCIHRDLAARNVLVAEDMTCKVSDFGLARDVKNMRVYEHQSGDNLPLRWMAVESLIDHTYTTESDVWSYGVLLWEIVNLGADPYPAINREEVKQEVQSGYRMPKPKHCQQELYDMMLKCWQEKPEDRPSFAFIGNELNRLMNVGKDYISTTNYDRTVYEISDLICEHERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMW8</accession>
    <name>A0A914AMW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065087.1">
        <property type="nucleotide sequence ID" value="XM_038209159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209159.1">
        <property type="protein sequence ID" value="XP_038065087.1"/>
        <property type="gene ID" value="LOC119735457"/>
    </dbReference>
    <dbReference type="GeneID" id="119735457"/>
    <dbReference type="OMA" id="CQMATSK"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037386916" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="18621" checksum="F0BBE9CB283E1019" modified="2023-02-22" version="1">MAFMRALCFVLLVGFTAAFQPDCSSKCPPKCPPMWTFYNGNCYRYFGTVKTFAQAENHCKEFTQVGQCHLASVASVEENSLLLTMLKSVRGTTTSSSMWIGFTDVAEEGNFIWTDGSAVGFTRWRSGQPWIKAGEADCTEMVSGWDGEWNDDPCGSTKAYMCQMATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN08</accession>
    <name>A0A914AN08_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064891.1">
        <property type="nucleotide sequence ID" value="XM_038208963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208963.1">
        <property type="protein sequence ID" value="XP_038064891.1"/>
        <property type="gene ID" value="LOC119735260"/>
    </dbReference>
    <dbReference type="GeneID" id="119735260"/>
    <dbReference type="OMA" id="STEATHF"/>
    <dbReference type="OrthoDB" id="10023911at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="188" mass="20222" checksum="4A8B4A5FE1219B23" modified="2023-02-22" version="1">FQSTLGGLFKSAQKAVGGAANTVVREVDRHVSSENLEMFNNGNIVSLQSRETSRCLQVSSCGVLSANGLQHDKSGHFRVVNCGQNVVLLQSAIYPSWYIANHGGRIVGNGSGDPSCKFRLHETMNGFITLESVASPNQHVGVNADGEMKPADLVRKENSAMWVPTVVCGPQPIVHVEQTTVTRSVHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANV4</accession>
    <name>A0A914ANV4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065293.1">
        <property type="nucleotide sequence ID" value="XM_038209365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209365.1">
        <property type="protein sequence ID" value="XP_038065293.1"/>
        <property type="gene ID" value="LOC119735600"/>
    </dbReference>
    <dbReference type="GeneID" id="119735600"/>
    <dbReference type="OMA" id="PPCDHEK"/>
    <dbReference type="OrthoDB" id="10065091at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="27990" checksum="43A036EDA1E7DDB2" modified="2023-02-22" version="1">MSRPVRTSTSSKAAEAKSNTHFLKNRVEELEAEVTSLKKRLDDLRKAKNTTVHKKQKEYVTTSTIEHKSGDDLKVSDLQRRMDDLNLQHTKEMEDLKRSHRDSLQKLKKAPSSPTPCNHEEEIAALKRKNKDLQSENEELKLFNEELKTENSAMREKFEELFAELSIKEAQWCEKEEQLNLKMKLQWGEKYREWMEVTEKKIADLQAANDLLGAHLNMGAVRMTLKCPTRSYMKNREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARC8</accession>
    <name>A0A914ARC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066162.1">
        <property type="nucleotide sequence ID" value="XM_038210234.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066317.1">
        <property type="nucleotide sequence ID" value="XM_038210389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210234.1">
        <property type="protein sequence ID" value="XP_038066162.1"/>
        <property type="gene ID" value="LOC119736174"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210389.1">
        <property type="protein sequence ID" value="XP_038066317.1"/>
        <property type="gene ID" value="LOC119736334"/>
    </dbReference>
    <dbReference type="GeneID" id="119736174"/>
    <dbReference type="GeneID" id="119736334"/>
    <dbReference type="OMA" id="KIANYAT"/>
    <dbReference type="OrthoDB" id="6092644at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="311" mass="35437" checksum="5DDB49457AFD81EF" modified="2023-02-22" version="1">MADLPEERLKPGPPFTQVGIDCFGPWEVVSRRTRGGTAQSKRWGMIFSCLTSRAVHIEVIEEMSTSSCINALRRFIALRGKVEVFWSDQGSNFVGVMNDKLFQSYLEKNDTQWKLNPPHAPHMGGVWERLIGVTKKILNGILLETKHQSLTHETLVTFMTEVMAIVNARPLVPLTSDPEDTSFLTPSMLLTQKHGSIDEVIVEDSASNMYRAQWKMVQVLADRFWKQWRLRYLQSLQHRRKWINPERNIAVGDVVLLRDKDIRRNQWPLGIVDGVSPGDDGLVRKVNVRLPSTGKTYARPVHELVLLVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARW2</accession>
    <name>A0A914ARW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066388.1">
        <property type="nucleotide sequence ID" value="XM_038210460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210460.1">
        <property type="protein sequence ID" value="XP_038066388.1"/>
        <property type="gene ID" value="LOC119736441"/>
    </dbReference>
    <dbReference type="GeneID" id="119736441"/>
    <dbReference type="OMA" id="YCTINVN"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="458"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="78975" checksum="92FE43E50FABFD08" modified="2023-02-22" version="1">MTKFDAAFKGFSLILFLGMIIFVDGHKFHPHQQIMYAAENRALQGFEYATKNVQSRVICGRECSMDESCKSFNFNYCSKLCELNLATRREHPENFNATQGSVYFDADENTPHYSMTDGSLNRNRGCKMLLDAGYRSSGIYTIYPEGFGDSGLRVYCDMETDGGGWIVFQRRQDGSVDFYRNWTEYQSGFGDLSGEFWLGNDNLVTLTSDDSLGTWELRVDLEDWDGNTAWAKYSDFKISSGEYNLIIGKYYASSTAGDDSLRHHRGSPFSTKDRDNDRATYKCAQYFHGAWWFNVCLHSNLNGRYYPNKHVTAGDRGVHWYYWKGSSYSLRTCQMKMHSSTMAKLYAGLKVCNLMVLLEVVILVSGHQFHTRQQLMYAAENRALQGLAYATKTVRSRAICGVKCGMDERCKSFNFNDYSKMCETNLATRREHPEYFNATQGSVYFDADEDTSLCSLTDSSFNRYKSCKMLFDACFRSSGIYTVYPEGFGNGGLRVYCDMETDGGGWIVFQRRQDGSVDFYRNWTEYQSGFGDLSGEFWLGNDNLVTLTSDDSRGTWELRVDLGDWENNTAWAKYSDFQISPGEYNLTIGQYDTSSTAGDSLGYNRDYAADRFHRGQPFSTKDRDNDAVNHSCAQKNTGAWWFNRCFISHLNGPYYPQGQVGRAEGVQWERWKGYNYSLKKCSMKMRELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASB9</accession>
    <name>A0A914ASB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066955.1">
        <property type="nucleotide sequence ID" value="XM_038211027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211027.1">
        <property type="protein sequence ID" value="XP_038066955.1"/>
        <property type="gene ID" value="LOC119736980"/>
    </dbReference>
    <dbReference type="GeneID" id="119736980"/>
    <dbReference type="OMA" id="YMSAHEN"/>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="226"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="511" mass="56191" checksum="2758897E84D900F6" modified="2023-02-22" version="1">MLDHAECVEDPTHFVHSQEHRKTMAGFNYCTRNLAWWFLLLMLGLLVKSSASEQYMAELCGRTIHAESSGGVLHSQRGPHYRNNVDCTVTITADPGRKILLTFLFLETEGIAPNCRSDYLQIWDHRDGDDQPAPDLVSLCDRFTGNVASKTNAVSLRFETDGSVTYRGFKLAYTSFKKAENGSCDLGEFLCDNSRCIDSSLKDDNFNHCGDYSDERHTFKAMDQLCGQTITAGKNAGLLHSQAAERYSNNLDCTVAIQADYDRTLLLRFEYLDIEGDGDGSGCLHRDVLMVYDGVSAGTVNRTLLCGSRAADIATSGRVATLRFKTDSSVAYRGFVVLYTSMRTPGASDCYWTEFRCTNNRCINANLTFNSFDNCGDNSDEQHFFTVGGGDDSIITTHSDTVFIVAAWVIVVIVIGCIVGLVLIVLCCAFICYLACRSSNRPAQQQASYTAVPAPPQQVGAPSTDYNQQPPMAMQTTGPPANPQPDGQAATYPQLHLEPSEQAPPPYEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT47</accession>
    <name>A0A914AT47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066649.1">
        <property type="nucleotide sequence ID" value="XM_038210721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210721.1">
        <property type="protein sequence ID" value="XP_038066649.1"/>
        <property type="gene ID" value="LOC119736709"/>
    </dbReference>
    <dbReference type="GeneID" id="119736709"/>
    <dbReference type="OrthoDB" id="5976912at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19533" checksum="B8A3A2660BEB269A" modified="2023-02-22" version="1">MARFEELVRKRCPRQCSNDTEKADSCQRLGLEDGTIPDERIRASSASYNRHAALARLNGPSYWVAIYCSPSCWIEVDLLQTTRVSGVITQGNKFPWVSYLVTEFKVSYKPKPTSGYEYIKETNGDIKLFDGGDIDSPSTPHTNYFNQAIMASAVRIYPTRYTLPAVDVRYGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATC7</accession>
    <name>A0A914ATC7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066601.1">
        <property type="nucleotide sequence ID" value="XM_038210673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210673.1">
        <property type="protein sequence ID" value="XP_038066601.1"/>
        <property type="gene ID" value="LOC119736658"/>
    </dbReference>
    <dbReference type="GeneID" id="119736658"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="HYR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="8">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="8">
        <location>
            <begin position="281"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="8">
        <location>
            <begin position="415"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="691"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="794"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="892"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="946" mass="100657" checksum="72A0B169AF7EE6C9" modified="2023-02-22" version="1">MVTMVTWTDPTATDSTNVDPIVECTPASGTDFVIGQTPVTCTATDAAGNKATPDCTFTVTVTDFNECTATNSDRHTCDESISVCMNTDGDYNCNCNAGYSHNNGDDKTCEDIDECQPSPCTNAQCTNTAGSFTCTCNAGYSQSSGDATMCIDDPPVFDTQCPADINRFADPRSTTTTVTWTDPMASDVVDGGSVNVVCNPPSGRDLQIGTHRVTCTATDSAGNTRDCSFDVIITDFNECTASMEAGRHDCVNAVCINEDGGFSCTCNDGYSKPNMNDHTCTDTEPPVFTPGSCPQAISRVADPRSMVTMVTWTDPTATDSTNVAPTVECTPASGTDFVIGQTPVTCTATDAAGNKATPDCTFTVTVTDFNECTASVGSPGRHDCVNAECNNEDGGFSCTCNNGYNKPNMDDHICTDTTPPVFDPNTCRSPDAQVADPESMTSTTVTWTTPTATDTTGIAPTVTCTPSTNHAFRIGDTDVTCTARDAAGNMALINCVFTVTVIDFDECTAVTNGHNCDTFANCTNTDGGFLCTCTAGYTGSGVTCTECADGFFGVECLSPCTCVQGADCNNVNGTCTCTPGFTNAVCDKNYLDVELSVTEEPVLDTAAVDNATLRCQVNLLSGDLVPINPVTITNPNGTSETASMIMEGLYEIIVHDISPDNSGKYTCTATTVINGVGLSDSDEFELDVLAPGRIISLNESTEGKLGETATVDCVVYARPRPVITWYNKNNAVIETTDPKYSISSVDGQERLTSSLSVLNLARSDNGTYFCETSNNLTLDRDRREAAIIVIEVPEVDNVDAMAISATEVEVIWRVSYDGNALPFMCKVDYQKPGRPDWTLGAFAEEPPLSRRITNLVAYMEYPVRVICQNRAGVGLEVMRPNPIRTLQAAPDAPEKVRVTAITSSSLTVKWDAPVIERGTIAHYVVTVDSAFDEPKSHQISAHYNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATC8</accession>
    <name>A0A914ATC8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067300.1">
        <property type="nucleotide sequence ID" value="XM_038211372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211372.1">
        <property type="protein sequence ID" value="XP_038067300.1"/>
        <property type="gene ID" value="LOC119737194"/>
    </dbReference>
    <dbReference type="GeneID" id="119737194"/>
    <dbReference type="OMA" id="CERHSHR"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037184661" evidence="2">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="17498" checksum="54BCE56949D36A7D" modified="2023-02-22" version="1">MFPVLILCLMLVSGVEGTWGTKNRDPSDGVMGPAGPAGPAGPSRVIVELGVRGAMGAPGPIGPAGRPGSDGPPGRRGSPGEDGSVGRQGARGVKGPRGPTGSDGRDGSDGATGAKGSTGSQGDKGPPGPPGPAGTAGMPFKNIQRNHTNPRSEKVQGGKTGTFSFRKTSQVQVVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATX4</accession>
    <name>A0A914ATX4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067123.1">
        <property type="nucleotide sequence ID" value="XM_038211195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211195.1">
        <property type="protein sequence ID" value="XP_038067123.1"/>
        <property type="gene ID" value="LOC119737101"/>
    </dbReference>
    <dbReference type="GeneID" id="119737101"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="185" mass="20309" checksum="E14A1232D348BC48" modified="2023-02-22" version="1">MAGTWLGCASLLGAETRYQCPADDSVFYNRPGNFSGFWDWPQAVFDDSNSLQVSYCLFMEGPTDQYTVTKALCKSTRDGQVMCERALQATTATPAPVENSAKVCYVLGEPDPDSDDQPRHRWFVPQPDPCACTEVRMGGLNARPVAKPFAVQFMDSVLVSEDQEEISSWLGCGGMTADDVTQEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVR5</accession>
    <name>A0A914AVR5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067852.1">
        <property type="nucleotide sequence ID" value="XM_038211924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVR5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211924.1">
        <property type="protein sequence ID" value="XP_038067852.1"/>
        <property type="gene ID" value="LOC119737508"/>
    </dbReference>
    <dbReference type="GeneID" id="119737508"/>
    <dbReference type="OMA" id="HFHTTTN"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="422" mass="46476" checksum="D859AB080567B4FC" modified="2023-02-22" version="1">MPRSFLVRRFVRPPVAEQSTKWDKCATPASDDEDYGPFSPSCLRIPTTPTKGQTVSAALPTTHRIIKPLHFHTTTNPYETIKKTTPKKHRSKGGKKGPRGAVGSNPLEEISAGENLASTPAGKQYISRSGRPVGRRVSTEKNDAYKQFVIKRNDIIVRDDRSKYSTSTTSTSFADNSQLYIDTSVLNLSMNGPLSQQSYGLVAATATATCVQAGQTSPTSADEATQPDIGRSSPDNQPQMTVLRNVFVSTPPDSKTDLSDVLNLRPDSPRELSVLTASSHVCPECGKGYSTSSNLARHRQTHRSVNDQKARKCPHCDKVYVSMPALSMHIRTHKLGCKCNLCGKCFSRPWLLQGHIRTHTGEKPFTCPKCGKAFADKSNLRAHVQTHSNVKPYVCNKCNKAFALKSYLYKHVEAACIRDVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXD9</accession>
    <name>A0A914AXD9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA excision repair protein ERCC-6-like 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068189.1">
        <property type="nucleotide sequence ID" value="XM_038212261.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212261.1">
        <property type="protein sequence ID" value="XP_038068189.1"/>
        <property type="gene ID" value="LOC119737712"/>
    </dbReference>
    <dbReference type="GeneID" id="119737712"/>
    <dbReference type="OMA" id="WANPDCL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20400">
        <property type="entry name" value="Tudor_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="263"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="639"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1544"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1260"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1364"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1556"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1567" mass="175695" checksum="D0C7FC9F08406E36" modified="2023-02-22" version="1">MEDNIEQWHVGGKCMAPYSGDGAYYRACIQSLTRRHQGRLMASVRFSGFTEEEDEIVDVRHLKKRPVRVPGDRGGTFTDSGSSGSVAPPSITSPLTYITEEDRLRAKYADLFDDSDHRGGAGNKSSKSRDSSASPMTSSSASSASSSRFISRSNHKRKAPVAVGGEVRILSEDVTPPKRSPVSSHAPPSMPVRELSEKDSFGFLDEGFSCEEMEKPYFPGVSTASAKIPLVLSKDDSGSVVQVPATINRYLRDYQREGVKFLYRQYQKGEGGILGDDMGLGKTVQVLAFLCAVLGKTGTREDCQRRLPEFLQKKLKTTRGHSSEVFLIICPNSVIYNWLDEFETWTYCTVGKYHGRERQETLWKAMKGKLDAVITSYETYRIYMDSLLQVKWAGVIVDEVHKIKEPGSQITQALKEVNTMRRYGLTGTALQNKLSELWCVLDWANPDCLGSLAKFKLNFEESISKGQKFHASKRELAESRKVSSQFAELRDQWMIRRTKALISHQLPTKDEKVVFCKLSALQLSIYQALLESDDMQLILKQKDTCDCGSGSIRIQCCYKYNSEGEKVKALTMTFMSLLIKVANHVALLTPDVSMSDVQRKRAQKYCDIAFARHPQFVALSREARFCTLSDPSYCGKMQILEKILTVFKQEGSKVLLFSYYTQLLNIIEMYLKTTDYVYRRLDGKTPIQDRQRFVHEFNTDPDIFLFLISTKAGGLGLNLTGANVVVIFDPNWNPTYDLQAQDRAYRIGQHRDVRVYRLISTGSIEENMYLRQVYKQQLASAAVTSENPMRYFTAVAGDKKQQGELFGLHNMFALRADTSCLTKDLIQRHVKTEQGITLAKYISPPPSVSDTEQTSKEEALSDSDGESDSSHGNHGNTDAEDDHGVASQFLGDGDFSDEETNDDPQKPAFKEHDTKRKTSPPNSINPPGKTTAPSCHKRNTAKTFVVPTSKRREHHAQMASGSDSDEDTKVDRRAVRGKAILHRDGRVERRIKGVAADQPNNSATRVKGQAKLGKRSEATSTKQDGGRVAGNRIRAKERNKSTNAVDDVFKECGVAFIHSNMKIVGGSRVEDHVTNIAMRDVYDLGLNSQQPANYNVPTLQESMSNSSSQEKDSVQSHEPLPASLLAQSQRASHRINGTTVLFGQTPRGIKRHQFGSMAKTLKHPSVRDFAKHILSLPQEQYASLLQDYYASKHLELDLAKLYQPLRPGAEELNDAPAQGRSARRAKPVRARVSRKHGTRTRGPRGVGHFESLSEDEEFDDRGNGRDGDVEHAERHETERCSDNNGKTFQATVRANRASRTASSKQGNLTRTKPTEQQRKRATKPLAEKSVIAERPHLRARRQVMDSENEDWLREDLNQNEKTDQLFQRRQPKTQNRNKSPSVSNDSSLEHSALSNSSPTTVPKDDNMSFLDEIFLTEKSKKPPKPPPKKKSPRVPPKRTTVCFVKGDLSDSDIEMEDLTDARLTSIDSIDTDARQVLEVSGGTLWKRNSKFASRQSALEQASVEAQLESQSVFEKYAESFVPNEHFLKRGLDKEHEIYVEETVMPEDSGFSPELRPSTSVVAETASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY76</accession>
    <name>A0A914AY76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069100.1">
        <property type="nucleotide sequence ID" value="XM_038213172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213172.1">
        <property type="protein sequence ID" value="XP_038069100.1"/>
        <property type="gene ID" value="LOC119738324"/>
    </dbReference>
    <dbReference type="GeneID" id="119738324"/>
    <dbReference type="OMA" id="YHANYAD"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="341"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="571" mass="64726" checksum="C6559456E84E7A3C" modified="2023-02-22" version="1">MIDLDSRGCGQRMGRFVLPPGDPCTCTGVRLGGHYHRYAPEMQGQDPPLYMDMLPEVTAEVIGRWFNCTESKPVESTLGVTETAPELTSKVAPGSTPVASTPTDTTQVISITPEPSMPPADCQVILDAGQSASGVYTIRHAGQNMQVYCRMELGKGYIVFQRRLDGSVSFDRTWQEYAEGFGNLTGEFWLGNQKLRSLTRNWGRDMVINLRAFDGEEARIRYEDFNVDSSENKYKLFVRWFSEDGGDAGDSLWTHSNEDFSTLDKDHDDTVGENCAEKFHGGWWYKRCGSDISHRFVSNLNGLYYNNATVDDYMGIQWVTWKGKAVSLKGCEMMTRPKCNWSITELPADCQEILDAGQTTSGVYTILDHYACQIMQVFCSMEPESGKGYIVFQRRLDGSVSFNRTWQGYAEGFGDLTGEFWLGNQKLHSLTRNGKWELVITLRAYDGDEARVRYGYFLMDSSELKYGIHLSGFSEESGDAGNSLRIHRNEDFSTLDKDHDNTNRHNCAEKFHGGWWYNRCGSYTSRDFKSNLNGLYYNNATVDDYMGIQWVTWKGKNISLKGCEMMIRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2I6</accession>
    <name>A0A914B2I6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070550.1">
        <property type="nucleotide sequence ID" value="XM_038214622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214622.1">
        <property type="protein sequence ID" value="XP_038070550.1"/>
        <property type="gene ID" value="LOC119739630"/>
    </dbReference>
    <dbReference type="GeneID" id="119739630"/>
    <dbReference type="OMA" id="VQTEFFF"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF12">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="625"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="769" mass="85541" checksum="7A2E7DC7F5377873" modified="2023-02-22" version="1">MFNKFAAALHHAVEVLAPTQTLLEDFTFHWKSVTHYFINTKDDKKPVQESNIPSHLDNMLALLTQEERQVEDDQTGPCMEYLLQHKILETLHTLGKADCPPGMKQVVLMFFLNLLGKIKQPLLPHVNVYKPVHNLIKVCGEVRAGPTEKEEIQFLCTVCSKLKQHPYSVNFFLELPRQKSKKPRHNSSTSAAGSSSRTSLDDITQPEFSLVNSLIALAQSPDSRIAVKACEGLMLCASLPEKQAAQCIVDHTQFCALLAERLCTLYNALPLSMDPVDVDSVEAKWGLYMLSDGEDTNMFPGKRQLISLLSWYDYCDQVIKEAHPIVGRSLANQIRERFLVPIMEQLLLQSSEVGILTSTAHLVKFVKMTSSPALLDVLIKFILGEETAPEKPGEGGYKLRQRLIDRCDNISDEICIMALKLFETLFLKSNGHIITNLVLRNLQSRVYHGRPAPTEHNNQGSGDSSDQRSSNPRDPCDQGCGDTADQGSGNPSDQGSVNGTVSDSGVETLSNGPESPTLVPDSPVRDGVPDFVSDPESEVAQASPSISVSSSEADDKPNIHKIVNSFLGLMPEEARSSYLTGDIGYDTYLREAHRLFRECSVNCLPYDWPNYATPLELCPNEAFYEGAFLKILLDKLSRMLDQTYEVNLQVTSLLSKICLFPHPHIQEFFLDPYLPVAAGCRTLHSVLLRVVSDLSARIKAIPDFQKQVLVVRKQLMGMVEEDDRGKKSIAPIMNLPYIDLLEGVIVLEEFCKELAAIAFVKFHAASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2M7</accession>
    <name>A0A914B2M7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038069756.1">
        <property type="nucleotide sequence ID" value="XM_038213828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2M7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213828.1">
        <property type="protein sequence ID" value="XP_038069756.1"/>
        <property type="gene ID" value="LOC119738859"/>
    </dbReference>
    <dbReference type="GeneID" id="119738859"/>
    <dbReference type="OMA" id="DERYHAW"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="44680" checksum="47E24E4689247AB1" modified="2023-02-22" version="1">MYLTRSKAKKAMGVIFVAITCFVAIQEIANRQSRVRKDTQESPPLAPGKQRESLMSETARENPSDVNLLHETPLERPSIKQEIANQPPNASSQNNPLYSDEVINQHIVNFTVVNGDACNRNASSQHRKVFLLILVKCRPGDSFPREQIRKTWGGLSEVDGKRILTMFLIGMTTNSTLMAKVVDENRQHGDIIQGDFMDHYLNLTHKTMMGWRWASEFCPGAEYVASADADVLLNLHNIVRRLSERPRERFAEGKVQAGAKPFRGNSKWHTSKETYPEPTYAPYFSGVCYVLSGDVAARVYKESAHVRFLPWDDVYIGLVLKRLGVVPKNVRKYLKFKESYQGIEDALSSGPAVLVGTEKDHAWTTHDRHNAQLVKIWKKVTQKQDATDRTKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2T2</accession>
    <name>A0A914B2T2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070645.1">
        <property type="nucleotide sequence ID" value="XM_038214717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2T2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214717.1">
        <property type="protein sequence ID" value="XP_038070645.1"/>
        <property type="gene ID" value="LOC119739695"/>
    </dbReference>
    <dbReference type="GeneID" id="119739695"/>
    <dbReference type="OMA" id="ISCFKAP"/>
    <dbReference type="OrthoDB" id="10041421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="517" mass="55261" checksum="DE4B868F0508EF8A" modified="2023-02-22" version="1">MARYGGLPCEVVATSDCKDANSDSIVLVASSLEKLTGCLELYKTVLLAQQKVDSSVGCSVSLIALPLNPPKALVFSPTGPINRDYDDVRRFADAAGAGIQRAITAGSKHPLLVCAPDDTFPKTNLVSLLGALQVLYVPFEIRQDVSSKAKKVEKLLVWCEDAASKDALIKQATAIESGRLVARDIGGSDPERMAAPNVAQYVAGLFQDSPSIKVSVVFDDNTLMQSYPLFSAVNRCAKLVQRHQGRIIKLEYTGAGEVKKTLMLVGKGVTYDTGGADIKAGGHMAGMHRDKCGAATVAGFFQTLDLLKPKNIKVIGTMAMVRNSVGVESYVSDEIITSRAGKRIRVGNTDAEGRMAMADCLCEMKEKAGNEVNPHLFTIATLTGHAIRAMGPKYTIILDNGPAFQTKNAQAVQAAGDQMGDPFEISTIRREDYEFHTGKSEYEDILQCNNEPSSSTARGHQSPAAFLIMTSGLDAHGIDSNQPLKYSHLDIAGSSGPFPGVPTGAPIPALTFMYLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5A8</accession>
    <name>A0A914B5A8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Charged multivesicular body protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Chromatin-modifying protein 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070666.1">
        <property type="nucleotide sequence ID" value="XM_038214738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5A8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214738.1">
        <property type="protein sequence ID" value="XP_038070666.1"/>
        <property type="gene ID" value="LOC119739710"/>
    </dbReference>
    <dbReference type="GeneID" id="119739710"/>
    <dbReference type="OMA" id="LQLQFMR"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057471">
        <property type="entry name" value="CHMP7_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF21">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25239">
        <property type="entry name" value="WHD_CHMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHMP7 winged helix" evidence="13">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="444" mass="49998" checksum="1CFB74801F7C70D4" modified="2023-02-22" version="1">MAEESKKSDRFPPSWGDDERMSYLFSDFRQNRMVNPNDWDNKLKFWSQLVGDCCRRDKSVVMDCERMVEGFRRKGRLPMGINRVLREMANNAQIVNTADFISSVNSTWVSWGVNNFLRRPLTWAIGSLFKSSEQPLTGNYIFMDVLKEIAESIVDLHQQCSNIDNADNLVEYTTLREVCQDVCGDETSLDLALLYLQKMKRVHVEAIADGSKVVKFVSKNQRTVTPLTETELGIVGLRRTINNLKKQIEQHEKDMNNLRNEAALTVRKGLKSSAKNILRRKKILERRLAKKETTLDTLQQLLDQIKGAETSTMTLEAYRAGASALKQTLKANGLTPEAVDDTLSDVQEVMELCAEIEDTMSQGNKAIDDSVSFSAGFDTETLEAELADLLDESTSQDIGETVKPTTDKSSMNQEDFLAGLPEVPETEPQNSDKAAKTTEPLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5K1</accession>
    <name>A0A914B5K1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 74</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Isoform 1 interacts (through WDR repeats) with NVL; the interaction is independent of RNA or pre-60S ribosome particles. Isoform 2 does not interact with NVL. Interacts with MTREX; the interaction dissociation in a late stage of rRNA synthesis is required for appropriate maturation of pre-60S particles and depends on the ATPase activity of NVL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071521.1">
        <property type="nucleotide sequence ID" value="XM_038215593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5K1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215593.1">
        <property type="protein sequence ID" value="XP_038071521.1"/>
        <property type="gene ID" value="LOC119740328"/>
    </dbReference>
    <dbReference type="GeneID" id="119740328"/>
    <dbReference type="CTD" id="54663"/>
    <dbReference type="OMA" id="KNVCRMR"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000214">
        <property type="entry name" value="WD repeat-containing protein 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000287">
        <property type="entry name" value="WD repeat-containing protein 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="41876" checksum="49AF1E2B50C7B8F4" modified="2023-02-22" version="1">MAALMNNVWLGTETGILKGVNVCKKIATNYCDLKKLDKEKEVTAMCWATEEEQQVLTGLRNGTVQTFDLEKGEFTDQQDCSGAEGVFRGLATHGDAVITCVESGLLKVWRGSDKESTEIKVGPNVRRMRQNPAKRNLVATGGNENDLKVWDLQDPEKPIFRAKNVRNDFLELRVPVCVNDMHFIPDSSKIVTCTGFHHVRLYDPSTPRRRPVLSVEFDEYPLMAMGITQGGNSVIVGNTHGAMAHIDLRKGQVLRAFKGFAGSIRSIECHPSLPLVASCGLDRFLRIHHIPSGTLDNKIYLKSRLNCLMFSSASFDTVDPEEILKAKERPAGPVDEEAENIWRQMEEVTEGSTKVKRMVSEVSTRSTTKRKAPAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B898</accession>
    <name>A0A914B898_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072381.1">
        <property type="nucleotide sequence ID" value="XM_038216453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B898"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216453.1">
        <property type="protein sequence ID" value="XP_038072381.1"/>
        <property type="gene ID" value="LOC119740947"/>
    </dbReference>
    <dbReference type="GeneID" id="119740947"/>
    <dbReference type="OrthoDB" id="9935774at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037724049" evidence="4">
        <location>
            <begin position="30"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="113"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="7">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="273"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="353"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="5">
        <location>
            <begin position="438"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1121" mass="121052" checksum="A2EBD6E5EA61F557" modified="2023-02-22" version="1">MIMIVTWNRSALIGLLAGFALLWAPVARCEDYEDHVFLSCPPNITINLTLVKAEAVATWQPPEISDTSGDYNFTSDHSSGDVFPIGDTTVHYTATDASSNTATCEFVVSVKDLRVLEFSNCPTDITQILQSGQSRDVAAWREPIISLEGREVSVTANHRPGELFDLGRTEVSYTAVDTLGNSAYCNFIVIVTGYPYNHFVLIEDSFLPGRDDRILLHSSVEECLIACIKEESFVCQSVDFSAKEKCMLSRTTAADLWGILAKHEGFAHYERLMEGTRPVLIGCPQHMTLPTEAGQAYATVSWREPTMSDGEPAVIKGTHSPKSRFYVGATRVVYTTSDSTGNTLSCDFFVTIKDEEPPIISNCPQNITKVTSDQEAVKASWVEPTATDNLGPPQLMSSNHRPGNWFPPGSTTVTYSARDNAGNRAECSFVILVEDIPDSNYIWLHLVLHNITYSDALQDNNSVEFQKLASTIEKDVLNIFRDDGTVLGVKIDRFRSDTDDGVAADVKIGFSEPLNHEDQQSKLHAILAAILNRVLANVAKVKLEQDNGKFQILDACTLSPCPATMNCRAIGLQCIAMCTDNAEYCLNGGHCGTNEQNLITCNCHGENQVYTYSGDRCDLTRMALSGKQLTIISLGGVWAAIMLGMLAMYCIAFRCRRRRKGFLSCYSEASIPLHVFADSPAEVPRGTHMVTSDDLGYTSQGEDELSPAESDSHIRIHLEDSREESPLDQSEGRPGGRLGAHDSMVGPHEGSARPHDGSTRPRNEVPGTHGGIPGTHDGIPGTHGGIPGTHDGIPDTHDGISGTHDGIPGTHDGIPGTHGGIPGTHDGIPGTHGGIPGTHDGIPGTHDGIPGTHDGILSPQGSKASPQESSLGSHDNSAIPGQSQSSSSCSSCTSCSSASDSSDCRSHTCSSCTCDSGTEVVQFPSLGDSNTTPKGAAITPTATPPQMTVQVDVERIPFEPSDSTHSYDGMIPDPLVESDVSVDESVPLINPHPQALDPPETTPFLSHCFDREMPECDQPISESASLLEIQPQVKRENMSEQRSVSSHGTHSYEGTIPDPVSEFDERRDKQSGDIRDPTPTGDGAPIELYNDESSSGQLFNIPSIHFVEESDDIVMTEEYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA75</accession>
    <name>A0A914BA75_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072740.1">
        <property type="nucleotide sequence ID" value="XM_038216812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA75"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216812.1">
        <property type="protein sequence ID" value="XP_038072740.1"/>
        <property type="gene ID" value="LOC119741123"/>
    </dbReference>
    <dbReference type="GeneID" id="119741123"/>
    <dbReference type="OMA" id="YWNTPAN"/>
    <dbReference type="OrthoDB" id="6097775at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037495135" evidence="16">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="249"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="469" mass="53016" checksum="2812B0E23CF20DAE" modified="2023-02-22" version="1">MSVVFIFIVMLSRLLVTAGNDTVVERSAQVRKISQEQRLVADLFQNYSSIIRPVMNQNETLIVTCDAALQTIADFNQKKQYIQTNMWLRLKWKDFNLQWNPDDYGGVSSITVPLDLIWRPDLHLHRNRNKDTSGISSISPRLTSSGVVYWNTPANIMSPCRYDASYFPFDEQHCQLTFSSWSYNYDAVHLRVSNSIADISNYQDNGIWDLLGMLQVVNTTYYTCCPKPFSVYIVTIVVRHRPLFYLSNLLIPCCLIVAITMCSFLLAVDSGEKISLVVTNLLSLVVFMNNLSKAIPNSSDGIPLMIQYIAVTIAIVTISMLATVCVLRIHYRPSLAKPVPAWLKKVAFVYLPPILILRVPAYKMTPATPAIGEPLREMPSSSDAGSDGGTTLANFVSINRRLRCLTARCKRQDAAREIVAEWKQVARVIDRMLFVVFLVVTVSLTMGILMQSKPQTSPEQIEIWQQPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC58</accession>
    <name>A0A914BC58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab-like protein 2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073611.1">
        <property type="nucleotide sequence ID" value="XM_038217683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BC58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217683.1">
        <property type="protein sequence ID" value="XP_038073611.1"/>
        <property type="gene ID" value="LOC119741787"/>
    </dbReference>
    <dbReference type="GeneID" id="119741787"/>
    <dbReference type="OMA" id="YHEAHAC"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001656">
        <property type="entry name" value="Rab11B GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26749" checksum="7561B9C76E65F259" modified="2023-02-22" version="1">MAASTSDAVLPETDGKTNENTVKIICLGDSAVGKSKLVERFLMDGYKPQQLSTYALTLFRYNTKVGGQEVTVDFWDTAGQERFSSMHPSYYHQAHACIMVFDVTRKVTYKNLPQWYKELRSYRPEIPCLLAANKIDVDYNITHKNFNFAKKYNLPFYFVSAADGANVVKLFREAIKSAAAYKANPTDFMDEVMQELENFDDLKLSPDGSLDLVNNSEDKESEKETSPASTPEGAPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCQ7</accession>
    <name>A0A914BCQ7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073829.1">
        <property type="nucleotide sequence ID" value="XM_038217901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217901.1">
        <property type="protein sequence ID" value="XP_038073829.1"/>
        <property type="gene ID" value="LOC119741940"/>
    </dbReference>
    <dbReference type="GeneID" id="119741940"/>
    <dbReference type="OMA" id="CWAAAKI"/>
    <dbReference type="OrthoDB" id="10049667at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="165" mass="18382" checksum="129C37967BC21D29" modified="2023-02-22" version="1">MYITLTTSPQPESEMTTDAQSPPTAEELERTIEQSGLILTKKNIADEESFVVELQEVFNVGYLTLHPLFALPVCWAAAKIRPAPGRPLNSELFDEADEVVDITTVVAFPKEVKKLQMPAQLDVFRCSRISLPPKKMGGPNEDALLIYSYKSQENNNKTANDVIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD12</accession>
    <name>A0A914BD12_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin heavy chain-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073944.1">
        <property type="nucleotide sequence ID" value="XM_038218016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD12"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218016.1">
        <property type="protein sequence ID" value="XP_038073944.1"/>
        <property type="gene ID" value="LOC119742009"/>
    </dbReference>
    <dbReference type="GeneID" id="119742009"/>
    <dbReference type="OMA" id="ESRMTDG"/>
    <dbReference type="OrthoDB" id="10533287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040417">
        <property type="entry name" value="GRP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33548">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037184671" description="Fibroin heavy chain-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="90240" checksum="25F8409BCFDC8C13" modified="2023-02-22" version="1">MARVVVWFTVLSLMLMAAHGQQQGILNKLRESRQDGAPQAWKKLRISSPQGVAPRTPLKAFQLVTNDVITGRRWKGLPREFTQAKNSMQDKDTYQMVYVEQERPQSFRQDPKNSFLVSNEIGHDFKQASQVRITGPDSGANLPDNALEQTRVGGSEPELSNEVVNHIRHEDPGTGHTDAVVSDHTQDEKSGPDLGNGPLKDDGSGSGLGDTPVSDLYRDDGSGSGLGNALVSDLYKDQGSGSGLGNVLVSDLYKDEGSGSGIGNALVSDLYKDQGSGSGLSNALVSDRYEDKGSGSGLGNSLVSDPYKGQGSGSGLGNALVSDLYKDEGSGSGLGNSLVSDPYKGQGSGSGLGNTLISDLYKDEGSGSGLGNSLVSDPYKGQGSGSGLGKALVSDLYKDQGSGSGLGNALVSDLYKDEGSGSGVGNSLVSDPYKGQGSGSGLGNALVSDLYKDEGSGSGLGNSLVSDPYKGQGSGSGLGNALVSDHYKDEGSGSGLGNSLVSDPYKDQGSGSFLGKVLVSDHYKDEGSGSGLGNSLVSDPYKGQGSGSGLGNALISDLYKDEGSGSGLGNSLVSDPYKGQGSGSGLGKALVSDLYKDQGSGSGLGNALVSALYKDEGSGSGVGNSLVSDPYKGQGSGSGLGNALVSDLYKDEGSGSGLGNSLVSDPYKGQGSGSGLGNALVSDHYKDEGSGSGLGNSLVSDPHKDQGSGSFLGKVLVSDHYKDEGSGSGLGNSLVSDPYKNQGSGSGLGKALVSDLYKDQGSGSGLVNALVSDLYKDEGSGSGLGNSLVPDLYKDQGSGSGLGNALVSDPYKDQGSGSGLGNALVPDLFEDEESGSGLGNSLVSDPYKDQGSGSGLGNALGPDHYNSDGSGFGLSNTVVSDHDQVDGSGSGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFE4</accession>
    <name>A0A914BFE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA helicase MCM8</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038074651.1">
        <property type="nucleotide sequence ID" value="XM_038218723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218723.1">
        <property type="protein sequence ID" value="XP_038074651.1"/>
        <property type="gene ID" value="LOC119742604"/>
    </dbReference>
    <dbReference type="GeneID" id="119742604"/>
    <dbReference type="CTD" id="84515"/>
    <dbReference type="OMA" id="THTVDWQ"/>
    <dbReference type="OrthoDB" id="422555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097362">
        <property type="term" value="C:MCM8-MCM9 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17759">
        <property type="entry name" value="MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000007">
        <property type="entry name" value="DNA helicase MCM8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058767">
        <property type="entry name" value="MCM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26065">
        <property type="entry name" value="MCM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="414"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="857" mass="94854" checksum="BEF38F72B1272D1C" modified="2023-02-22" version="1">MSNNDRGGSQGRGRGWQRGQGRGQGRGGTYRGRGRGGGWRGYNGNRGGRNSNYSTNRGPTSSTRHADASIVEALTPYKGWRYYFKDEGYSEHSPTVAKVKAFEKFFKSRMKAYDKDEIERKGSITVDYKELIEDDDVSETLPDLRTDIKDLPEKTLNCLGLSIHQTLTRDLEHQATMLQQQATGETGQQEVEVPSILVSVPIIRARLVNYEPVTPLKNLKANYYGKFVTVRGTVVRVSNIKPFCTKMAFQCNMCGDIQIVNLPEGKYTLPTKCLAPGCRGRSFAPKQSSPLTETVDWQMIKVQEIMMDGQRESGRIPRTVECELTCDLVDCCVPGDVVTIGGVVKVSNIDEGHGRNKDKCMFLLYLHANSVQNQKRGKKAASAGEGSPSRTGIAMDFTLKELYAIQEIQDQKNLFRLIVGSLCPAIYGHEMVKAGLILGLFGGTHRFVNDKNRIPVRGDPHILVVGDPGLGKSQMLQAASNVAPRGVYVCGNTTTTSGLTVTLSKEGGSGDYALEAGALVLGDQGCCCIDEFDKMGNQHQALLEAMEQQSISIAKAGVVCSLPARTSILAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDKPDEEMDSMLSEHVMALHAGKKRATEGAHSSMDAQATDPEQTQALRLWESDRPISERLKVGRGEAFDPVPPQLIRKYIAYARKYVHPKLSSEAATVLQNFYLELRRQHKGRDSTPITTRQLESLVRLTEARARLELREKAEQQDAEDVVELMKFSMIDTYSDEFGFLDFQRSQHGSGMSSRSKAKRFIAVLNRVAEQTYNSLFSVQQMRDIARDANISMPDFEGFVASLNNQNYLLKKGPRVYQLQTASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGN9</accession>
    <name>A0A914BGN9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075259.1">
        <property type="nucleotide sequence ID" value="XM_038219331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219331.1">
        <property type="protein sequence ID" value="XP_038075259.1"/>
        <property type="gene ID" value="LOC119743023"/>
    </dbReference>
    <dbReference type="GeneID" id="119743023"/>
    <dbReference type="OMA" id="ICYENPC"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF44">
        <property type="entry name" value="LDL RECEPTOR RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037686627" evidence="10">
        <location>
            <begin position="29"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="8">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="366"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="427"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="467"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="567"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="642"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="829" mass="88391" checksum="9E6A9B6710D45DD2" modified="2023-02-22" version="1">MGHLLVEGLLGVVWVFLLLGAAFQPVQAGDFALVADLHNGTIYGGSMGRGLADIAPLPLNDVKRPVAVDYDPIDRMVYWSDLASLPSPRISRAHLNGSSQMIVVDQLHLPDGLALDVEARMMYWTDGIIGYIGRVRMDGTGGRETIVDGLDKPRTIIIDHENGFIYWTDWGNSSKIERADLDGSNRMTLVSDDLVWPNGVVKDGDKLYWCDANLDKIERSDLSGNNRELLIDLTSYSNIHPFDLAVYGDYVYWTDWGYVTLIRVHTSGVGAQNYGPHTFQQSGGLHIEKEPNYCDSTPCHNGATCVDVINGFSCICPAGYQGLTCFEDPCGSGPCANGATCTILPTSGFNCQCPSGYAGPTCMMVVHCVVSLDPSDVLMVTSGQRDVYLPGESVTFACPDGYQFGGSATRFCQSDFTWSGQPAECIQEDPCGSRPCANGATCTILPTGGFNCQCPSGYAGPTCMMVVHCVVSLDPSDVLMVTSGQQDVYLPGESVTFACPDGYQLGGSAMRFCQLDFTWSGQPAECIQEDRCNSGPCLNGGTCTSVQGGFTCHCLAGYDGDTCSIVIGCLPPITSTHVTLVESDIALFQAGEVATFMCDSGYAVTGSTNDQSATRVCLSGGTWSGEPVSCSPTSPNPTPPVIGCLPPITSNHVTLVESDVALFQAGEVATFMCDRGYAVTGSRSDQSATRVCLSGGTWSGDQVLCSLTSPNPTPAPPEKSYVSAIAGGGCGLAFLILVLFGVLVVMKRRRIRNGDRTVRVPVNMDLIVAGKTNYGEAHHGSDNPTHIYETSVCQSWQAHGNPPPPPHVSAPDPIYMDVSDYDTSLVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIY5</accession>
    <name>A0A914BIY5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075870.1">
        <property type="nucleotide sequence ID" value="XM_038219942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219942.1">
        <property type="protein sequence ID" value="XP_038075870.1"/>
        <property type="gene ID" value="LOC119743520"/>
    </dbReference>
    <dbReference type="GeneID" id="119743520"/>
    <dbReference type="OMA" id="NDIFQCK"/>
    <dbReference type="OrthoDB" id="10058437at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="25331" checksum="4DA493A00B45A68B" modified="2023-02-22" version="1">MSYLGPPPAQHVILLDKISRALIAEDIPRFKNRCLAEGVRPGEVERHSVLELLQLLDRRRVIAPGKYDKLVQVLTDIGRGDLVQEFFPLKRGQENQSTASPISCQKETDNHPPHHHCRHHSATPTMNSVVTEKALSWLASKMGADWEQIGIQCLGMSKNDIFQCKADNPYTVQNQIFSLLNKWRCRSGYNVTYAQLFEMLLQFQEFDKNILEEMQTKIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJH3</accession>
    <name>A0A914BJH3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075592.1">
        <property type="nucleotide sequence ID" value="XM_038219664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219664.1">
        <property type="protein sequence ID" value="XP_038075592.1"/>
        <property type="gene ID" value="LOC119743262"/>
    </dbReference>
    <dbReference type="GeneID" id="119743262"/>
    <dbReference type="OMA" id="SICQMAR"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038127784" evidence="2">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="89" mass="9560" checksum="F6D94DADB7C9CE28" modified="2023-02-22" version="1">MAQARFFEHGLLGALCTPCLACSLARQLGESCCVVACVPGGVFALRTKLRMQQNIEGSICDDCLTLSCCCPFALCQMARELDNAEIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLE6</accession>
    <name>A0A914BLE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Profilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis. Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076287.1">
        <property type="nucleotide sequence ID" value="XM_038220359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220359.1">
        <property type="protein sequence ID" value="XP_038076287.1"/>
        <property type="gene ID" value="LOC119744431"/>
    </dbReference>
    <dbReference type="GeneID" id="119744431"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000007">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF2">
        <property type="entry name" value="PROFILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="18767" checksum="9286398CEDB3B21D" modified="2023-02-22" version="1">MASILKSSHLTMGMEALALLVSFLEKDDLRGDTQEDRVKMNQLQNLLHGALIATEHVENSAIIRRRDVSLRASSAGFTVSNDQIQRFIDAFKDPSATREKGLYFNDRIYQCVRADKSSIYAKSDKLGIVLVRTATLIIIGTYNDNMFPSVCVEAVEKLASYFKEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLY1</accession>
    <name>A0A914BLY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038076771.1">
        <property type="nucleotide sequence ID" value="XM_038220843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220843.1">
        <property type="protein sequence ID" value="XP_038076771.1"/>
        <property type="gene ID" value="LOC119744746"/>
    </dbReference>
    <dbReference type="GeneID" id="119744746"/>
    <dbReference type="OMA" id="GKHRWTA"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="574"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="777" mass="88172" checksum="E0B66A90FC84403C" modified="2023-02-22" version="1">MEKKSVDVVTQDGRKPAPAKPPGSSVNPFVNNNMEGSQQKLTFEEQIGHRKPSKVYMAILIVLVLATIAVLVPLVVIVLERNELAKEVAELKSAHTPQTCTSQQCIKSAAICLDSMNRDADPCDNFFEYACGGWIKQKVIPDDKSSYSAFTVLREQVEIKCKELFEREGKEDEAKPIISVRNIYKSCLDLDRINERNSEPLLDLLVTVGGWPVLGNLTGGNWDPTTFHFETLWALLNGKYGSDMIVSSWVSVDDKNSSSHILKLDQPSLGLRSRDYYRNVEFEEERAAYLQYMVDIIVELGGDEAAARSDMSDVMTFETAIANMSIPKDERRDNEKLYNIFTLEELNAAYPQINWTLFYDLIMPDKVKPILPTERIVNKVPLYLKNVTEWLVRQDNRVIANYMVWRLVNGMVSDLGQIFIDIRQRYLNVLLGTSSTPARWKRCVIEANNVLEFATGRMYVEEYFPAIAKEKTIEMIGNLKIAFKAMLETNDWLQEADKRVAAEKADQMRIDVGYPDWIMDDAMLDEKYKGLDFVADGYFENSLLYLRWSKVESLSLLRDVVDRTEWTAGPAVVNAYFSASKNRILFPAGILQPPFYHQDLPWYSNYGGIGVVIGHEITHGFDDGGRQYDKDGNLVDWWSADSVVKFKERAQCIVDQYGSFVMPETNENMNGVQTQGENIADNGGLKESYKAYKDNVPDEPLLPGLNLSADQMFFLTFGQMWCSVYRPEGVTSQILGGVHSPGRYRVIGPMQNNEVFARAFNCSPSSYMNPTDKCNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BM02</accession>
    <name>A0A914BM02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077149.1">
        <property type="nucleotide sequence ID" value="XM_038221221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BM02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221221.1">
        <property type="protein sequence ID" value="XP_038077149.1"/>
        <property type="gene ID" value="LOC119744997"/>
    </dbReference>
    <dbReference type="GeneID" id="119744997"/>
    <dbReference type="OMA" id="IMSFTEP"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34541" checksum="439D098D7EC06EF9" modified="2023-02-22" version="1">MNPHGEPNPQLDAYEVSFGVLSALTVVLILTLNPICLVALYRANGIQESTKVFMASLTVSDICIGLFWVLPELTRHFNGEWVLGSFLCTVWGVSLTSFSALSMFSLVLLTVDRFFAIVYSLRYPTLMTLKKAKIIVATTWSMTLTFNIIVYGIFLPNAISPRKCYVNWTTFKIFAPIVVSEIAISLVTIFILYMYILNVARQQARRIAAQNQISVELGDQNAPQRVGTKSATTVFIITMTVFICWIPSVIFTVDFSISGALPVDFSDITNLIFATNSWLNVVIYYLRNRELRQTLHELIASCFHRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP08</accession>
    <name>A0A914BP08_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077227.1">
        <property type="nucleotide sequence ID" value="XM_038221299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221299.1">
        <property type="protein sequence ID" value="XP_038077227.1"/>
        <property type="gene ID" value="LOC119745077"/>
    </dbReference>
    <dbReference type="GeneID" id="119745077"/>
    <dbReference type="OMA" id="ESHARYE"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="3">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="35128" checksum="44268FE997CEF0E4" modified="2023-02-22" version="1">MATISVSPSSSLMDERVVISVAGLASHCPVTVRSHVTEITKRFQGWAHLIADEDGRVSLDKDPSIGGTYSGVEPMGLFWSLQPCPGQQLGIRFAKKHPDKPVVVILSLHRGHLDETQLATDEPIHVAVAHKWYMRETDVDRIKLTGHDFIRGVVYKPKGPGPFPAVLDMFGTAGGLMEFRAALLASRGYASYALPIFAYEDLSETMLNVDFEYFEEALKWFAAQSYVQPGGIGIVASSMGGSIGLHLAIKYPQLIKATAFVSCPPFMPNVTLNYRGKALPFVWFDTEATTFDDEGVLHPLTGWPAARDIKDKEFIELFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP77</accession>
    <name>A0A914BP77_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077939.1">
        <property type="nucleotide sequence ID" value="XM_038222011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP77"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222011.1">
        <property type="protein sequence ID" value="XP_038077939.1"/>
        <property type="gene ID" value="LOC119745563"/>
    </dbReference>
    <dbReference type="GeneID" id="119745563"/>
    <dbReference type="OMA" id="VWLWDRG"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000063">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000034">
        <property type="entry name" value="kinesin-like protein KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="7"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="976"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="896"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118098" checksum="B72321EAFD1FE86C" modified="2023-02-22" version="1">MSGGGESVKVAVRVRPFNSREKERGAKLVVEMKGATTKLLCGDGSGEEPKTFTFDYSYWSHDGFTEQPDGILLADPGSSYASQQNVFNDLGQGVLDNAFQGFNCSLFAYGQTGSGKSYSMVGYGNNKGIVPITCDVLFKTIEASDGKTKYEVTFSMLEIYNEQVRDLLQKVNPKGGLQVRQNPKEGLFYVQALKKVAVGSYREIENKIEEGTSNRTVAATQMNATSSRAHTVVTIQFDQISKNDVGQETKKTSVINLVDLAGSERADSTGATGDRLKEGANINKSLSSLGNVISALADLSMGKKKVLVPYRDSVLTKLLQNALGGNSKTIMIAALSPADINHDETLGTLRYADRAKKIKNKAVVNENPVEKLIRELREENERLKSAMTGGGIVAPEGGVNMSPEEKEKMRQQMMEEIKAQLMANQEAMEDFDWDKKHQQQMEDEPTLDHKAINQSRRSKEPHFANLNEDNMLSNVVFHFLGSDETTIGRKDADPQPTIMLSGLSISKQHAIITNSDGEITLRPYSSSCKIKVNGVPLAGARSLEHLDRVMFGSNHLFVFHNPLNPKAAEGTPPVVEWEFAQKELAEARGLMAGGNLTQDQQRTQDQIVELLPMVNEVNAVSEELDKHKGFEIVLLSEEAQEGTNRETKVMVKMKDLLNQNSWLWERGKFINRRYVIQELYQRYIDGDEHVLKMPKEEDPFWEPPEDVLIGTANVFLQSLSYYLDFDDKVAVTDFKGKEEGSLVVCIAPCNQNGQPIGEDDFVDDPNELLGKPYHFKVNIRNGEIHKSRFSHGLKVKYKCYNENEYTWTDEKKETLSPEWNHSRIVSIPSTTEDVLSYFENSSVKFSVYGRQIDTAPDSKLTKLTTKELRQMENMQDSGRKARIGSSAVDADGQDEVGQIKGELLLLKRKFERLEKKERRLQEICKQWEQKPAEEQQFEPFYRSVSAVAFSTGAKLKTRVHMLNKEDSVSVFSFELEASSPRSKQPIKEEPEPAPKQKDEATPPPRIVEEPKPVPATNGETPKRAEVPSKGSQDAVNGAKVVQTNGDQKAQGGSKACAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPE5</accession>
    <name>A0A914BPE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077362.1">
        <property type="nucleotide sequence ID" value="XM_038221434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221434.1">
        <property type="protein sequence ID" value="XP_038077362.1"/>
        <property type="gene ID" value="LOC119745211"/>
    </dbReference>
    <dbReference type="GeneID" id="119745211"/>
    <dbReference type="OrthoDB" id="6577359at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="32112" checksum="F2F01BBBE5EADC69" modified="2023-02-22" version="1">MTSAQGAGDKQREEADVVCHSEASQNPVDCLPNEILWKIIGFLSLEDLCYLAVCSKTWRNVTNTNSLWLHLCKLRDWERFGTEVDLRKETPIHSTGTSTSGTSPTFQTDSVINDDCNLKDLAPTCEWKEVYMRAWHLDRNWSEGRYQEHSLVLSDSGSDFNNATTRCVASDGTIFGAGDTTEYVGLWELKSGQFLQKIQPSKYIPLPRTSYNEIEAMTMKDNIGVAAFMGGILVFEASTGNVLKLIRGTASDFDRYKPSGLYMEEDKVIVSYRHYQRADNDEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQE1</accession>
    <name>A0A914BQE1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HDGF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078368.1">
        <property type="nucleotide sequence ID" value="XM_038222440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078369.1">
        <property type="nucleotide sequence ID" value="XM_038222441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQE1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222440.1">
        <property type="protein sequence ID" value="XP_038078368.1"/>
        <property type="gene ID" value="LOC119745820"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222441.1">
        <property type="protein sequence ID" value="XP_038078369.1"/>
        <property type="gene ID" value="LOC119745820"/>
    </dbReference>
    <dbReference type="GeneID" id="119745820"/>
    <dbReference type="CTD" id="84717"/>
    <dbReference type="OMA" id="NSDQEFT"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05834">
        <property type="entry name" value="PWWP_HRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000017">
        <property type="entry name" value="hepatoma-derived growth factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="951" mass="109366" checksum="63F3603C8961AF48" modified="2023-02-22" version="1">MAGRNFKPGDKVFAKMKGWPHWPARIDMVPEGAVKPPPNKLPIFFYGTHETAFMLPKDLFPYEEYKHKYGQTHKKHKAFNFGLEEIIDNPDVNLYAQQPPSTSEEEIEEEEEEEEVGEAEPESSEEEEEEEEPLAKKIKPKEKTASAKKRKKSVDTAKKSSKKKKALSSDEAETDYEELSEEEEVEEADESDEFVPEKPSSGRSKKKDSKRSKPRERKKSRARSSSSSEEDQDEAGQSEEEKAASSSDSESDDEPVVKKPKKERVKKESVKKPRTKAEKKPRAPRTKKKSPSVPAPKKELSISLSSSDSSSDDSDYVSKWRKQEEARRAKIEEEKKKKQEEQYRLMREKERLQEEMERLEKAQKKKKKKKRSSSESKDKHVESEDEERRLVDSDDDSDHLVIDETPLTIKPKRETKKKAKNNEAPAKVVKEEQVVPRTVEDEDEEEEDEVDKPSVEGSKTDPADRKAEKLKKKEDKDKKRQEKERKKQEEKERKKEEKLKKKLEEKKKELEAKKRREEERRRREEEEAQRQKEAKKRREEARKRQEEEQRQMEEQQRKEEEMKPAAMEQSNDKEISKPDKLERKRPEKKKGLSKLEETVERLHLELKVSLSMDHPDPAKSLAVMAQIDDLGGTLTPGVLRKSKDFVQTIKKVRKYKPDEKVRKKAEYLYNKLKSICLMQETTGGVEEKKHITEQTDITAAEDNTGGDMKPVVEPRIQENGTPEDEPSKTNVEDQVTANADTKATANTPTEEAFSALADPPVELPKAEDSEHLGAKELPEEPIEEPKEESVPEPEPVRTEDETDNKRTVGDDVRPKDVENKEEDAFAVKDEVEEGEVEEGEVGEADEEDDEEGEGRRDLSERLEKIFGSQGGFQIPGLVMDGGEEKPKGSGEKRREQKRDRRRSTGMSGDQIGEQPMDLDEDTEEGNNSKGENTATDQAFSDDNMDLDSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BS07</accession>
    <name>A0A914BS07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078959.1">
        <property type="nucleotide sequence ID" value="XM_038223031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BS07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223031.1">
        <property type="protein sequence ID" value="XP_038078959.1"/>
        <property type="gene ID" value="LOC119746216"/>
    </dbReference>
    <dbReference type="GeneID" id="119746216"/>
    <dbReference type="OMA" id="YNIMSDR"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="45407" checksum="CD0D8E85AB7A8A83" modified="2023-02-22" version="1">MAGTEGYTLLDDQDHAMNTTYSGSIINIPDNPDQAEAMSPVNVTDANLHLFLYSTVDTLLVTAVMPLIFTIGVLGNLAVIAVFVRVRSMRTVTNHYLVSLAVADLTFILLSVPQFWVMYATSPLFGDYRVLQSGYCKLTIYLTESSIIASCFTVILVTFERYVAICWPHKFKELSTKPRAVLLCTLVWVFALGYKIPTLCFSTVVEKEIVWMISAKTVTYPDSIYTCYFCYPEESNMCNAFKKSLTLDQIMLLMVIPITMVMYSLIVLQLQKLAKSTMIRGTGSSSSTRMKKQVVRMLIVTITLFVICMTPFRILNLFNIYNFKLPPNSQWVLVNVGRIMLYTNCSVNPIIYNIMSDRYRQAFHDTFLCCLPKRGEANHEQSSCNRKTTKYTASMWAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTC4</accession>
    <name>A0A914BTC4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079240.1">
        <property type="nucleotide sequence ID" value="XM_038223312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223312.1">
        <property type="protein sequence ID" value="XP_038079240.1"/>
        <property type="gene ID" value="LOC119746398"/>
    </dbReference>
    <dbReference type="GeneID" id="119746398"/>
    <dbReference type="OMA" id="WLYREIT"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF418">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="359" mass="40812" checksum="68A1E1E82BDE5A8D" modified="2023-02-22" version="1">MHQNTFYFDASKNEICLENCGGMNGAFDIIKCTVVGIIALLIIIGNIFCLLVLWRTKEIHLISRLFMAALTATDLTFGFLVVLPVAVSSAYNIWPVIHDTMCHFHEAITSVLGGALTMSLLGISIDRLIAVCKPLQYPTIMTQRRALILIITLWALPFIYRIISKWSIGLYQLQFRSDSDMCWVCTKQTGHTVYTAGVGLFMVIPCFCTFCIYARLFVIARRHARRIAVLPNNVPQNMDGEVFNMHTKSAVTFLLITATFGICWMPFTGVWLYREITGEATSEYLVVAAQLTTFSSSWLDCLVYYYRSKVFKRTARKMICKMCCCLRSSRRNTTRLPTVRTINVREAHELDCSTTSDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTD5</accession>
    <name>A0A914BTD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Proton-coupled zinc antiporter SLC30A9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 30 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc transporter 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078807.1">
        <property type="nucleotide sequence ID" value="XM_038222879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222879.1">
        <property type="protein sequence ID" value="XP_038078807.1"/>
        <property type="gene ID" value="LOC119746089"/>
    </dbReference>
    <dbReference type="GeneID" id="119746089"/>
    <dbReference type="OMA" id="HSMFSEC"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009882">
        <property type="term" value="F:blue light photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21078">
        <property type="entry name" value="NTD_ZNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000004">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000002">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007024">
        <property type="entry name" value="BLUF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50925">
        <property type="entry name" value="BLUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="BLUF" evidence="24">
        <location>
            <begin position="497"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="574" mass="64188" checksum="542E6A568D169135" modified="2023-02-22" version="1">MSFSPAIIRIARQLVFQPAFHRYNGKPIFASNFKTSRNHLRFSRANTSPLLTWWGLRAMCTHKDGDKQGKDGDKGEQTAEQTPQQTTQGTENVKKEDENNVAQARSTKLPTETKTVSYKDKRRRIDYSKKYTDNITITAVRAMSEYLLKSSDLEQLRKTTRRSPYEQEGNSEAMMVFLRSDVEAKAIEVWGSKEALELEKKRRKQREDIYKEHVFLLKRAMKEFDSYFGEAKPPKPSFFEGAGKVVMSAIIINAANFLFKLVAWMYSGSSSMFSEAIHSAADVCNQVILALGIRQSIKGPSPDHPYGFTTIRYVSSLISGVAIFCIGAGLSCYHGIMGLIHPEPMESLLWSYCILAGALLTEGATLSIAYNAIKKGAKEKQQSFTEYVLRSRDPSINVVLLEDAAAVLGVLVAAGCMGLTSWTGNPMYDSLGSLAIGSILGFVSVFLIYSNTEALLGRSIPETELLKISSLLENDVMVRGVYDVKATDMGVGTIRFKAELDFDGKEVTRSYLDGQDLESLLKELQTYTTMEEIEGFMLKHGERIIDKLGAEVDRIEKEIKKLNPDVRHVDLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTQ4</accession>
    <name>A0A914BTQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079002.1">
        <property type="nucleotide sequence ID" value="XM_038223074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223074.1">
        <property type="protein sequence ID" value="XP_038079002.1"/>
        <property type="gene ID" value="LOC119746244"/>
    </dbReference>
    <dbReference type="GeneID" id="119746244"/>
    <dbReference type="OMA" id="NATYFRY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037344197" description="Carboxylesterase type B domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="615" mass="68627" checksum="28A905B97C161830" modified="2023-02-22" version="1">MTDSFLVVANALRVILVLNVFLAQTAAQTAAQDAPTVTVQQGVLVGTTETFQESQFIGVNKTIDVFKGIPFAELPVGRLRFEPPVAKEPWVGTYDATYFRDACVQDPLQAFGMPMSEDCLHLNIYATRTTFPEGAAVMVYIHSGSLNGGSAVLPDFNGLPLVSVGDVILVTINYRLNVFGFLTTGDEASPGNVGLKDQVMALEWIKQNIAAFGGDKERITIFGVGSGGLSVNLLVLSQQTTGLFSQAIMQSVTALSPSFYEDQELLRQQAFQVGERVGCRVSDSVALLDCLREINATALITAAPQSLFRSAPVLDGTFLDDTPANLYATGRYNHVKLLLGSNKDEGTFNVYLSQQFGEYRTKEQAPIINEEAFDQLVTEKFVRDYGYSNDQLTDAIRMQYIDWSQADNDSYDFFRSYVDFATDFSYACPVDQVARYHAQSGDDVYVYQMTHVPSVSYWNYGGFGPGWLLAGHAEDVQFVFGFPFIPAATALRGELQDDEKALSVKFMEFWTNFANTGNPGVQTPGSPPDPQRDFWPRFTIPELEYKELSLNLTSSRALKSDKCHFWNSYMVQLRTMLADLDVAEREWREAFHTWKYTDLADWRYQFAEYKAINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU11</accession>
    <name>A0A914BU11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079267.1">
        <property type="nucleotide sequence ID" value="XM_038223339.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079268.1">
        <property type="nucleotide sequence ID" value="XM_038223340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BU11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223339.1">
        <property type="protein sequence ID" value="XP_038079267.1"/>
        <property type="gene ID" value="LOC119746417"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223340.1">
        <property type="protein sequence ID" value="XP_038079268.1"/>
        <property type="gene ID" value="LOC119746417"/>
    </dbReference>
    <dbReference type="GeneID" id="119746417"/>
    <dbReference type="OMA" id="SLMVRED"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="4">
        <location>
            <begin position="33"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="593"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="867" mass="96365" checksum="A7C4A44306D7F20B" modified="2023-02-22" version="1">MEKLLPGRRLVHRTWVILVLEYLVCYATVITATSGMFQDQVPKFVTSESYYADLRMFPGQSLTAMSLSLDGSQLYLGGKNMFFIMNLTQPFGQSSAIRNVSWVSETSVIDSCEMKGKQGWQCQNFVQVVLMNNETNRLLVCGTNAWAPLCRYFSPNTLGNYEELNGVKRCPFSPEQKSTAIFADGALYSAAVTGFTAVDSVIMRSMQGDVIETKDVDTKWLKVPEFIKSFEVGDWVVFFFREIAVEHVNSGEAIYSRVAKVCKNDIGGDWVLERKFTTFQKARLNCSFPGSFPFYFNYLQDVHMVGEGSNIIFYGVFTTGDHEIPGSAVCVFSLDKIEEIINEGQFKRQQQGTWYPVPVDDVPDPRPGLCAENSKAVPQNTLEFILAHPLMHQSVPNLGGDRPRFDLTRADFRIMQVVVHKQKAANDKTYDVLFLGTDDGRVLKVVIFQDTNGQYRSNLLEEIFISPRDHSEGVVNMEAIQQQIGQPQVILVNTNSTVVELPLQRCKNLTECACQQDPYCVYNNLSQMCVRFHDNKYDSSDVEDIRDCPKEEVPVPQTTTPVECFCPTAQPCVKTGKDCDGEDPDNLPTTIHPPAAVATSSSSPTSPRELITTPKKGTTLQTTEGQTTIPPRSTPRPPIVQNTDNEVHVKTSPTQKIPTKGPNAVDPYLGESVGYNKGPPSPVFWSFFAIGWLIAFILMVFLIHLFVTKRCKGNYQPTDTEESVLGSSYKPSPKIVKTVLPSENGKPPLMTSMQESPVRVTPVNGSLPQSRTHSLTPSTDPNLRNSTNGSYQPPRGSFTYGMDNSYLTPYPGGSLERRHPPTGGVDEGSPHRLPSETESRPSASGASDSEQCDDSDIWLKMPDDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZY1</accession>
    <name>A0A913YZY1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045133.1">
        <property type="nucleotide sequence ID" value="XM_038189205.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045147.1">
        <property type="nucleotide sequence ID" value="XM_038189219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189205.1">
        <property type="protein sequence ID" value="XP_038045133.1"/>
        <property type="gene ID" value="LOC119719708"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189219.1">
        <property type="protein sequence ID" value="XP_038045147.1"/>
        <property type="gene ID" value="LOC119719720"/>
    </dbReference>
    <dbReference type="GeneID" id="119719708"/>
    <dbReference type="GeneID" id="119719720"/>
    <dbReference type="OrthoDB" id="10221790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="246" mass="26061" checksum="F15D7BB8A3918735" modified="2023-02-22" version="1">MQGPPSTTEKSTTRVTTTEALLTTAPPSTTAQPSTTAPPSTTMEVTTVVTTTPESTTKEVTTVESTTVSTTSPPSTTPEVCADDLDKLPNVTIIREDPESGKELPPTEWWRPSNPPNDVTSPHNGSCLGATFSPRVEITSVIIKTEQGPPGDITVSFKFQPGDRQPYLPLVDEAGSPIFIGKTDQKIYLPSSMALVTGLKVCIITSNPDGYKVIFNGCEHGVTTTKAPSTTEAPSTTGELGFCLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3F3</accession>
    <name>A0A913Z3F3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAM20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046242.1">
        <property type="nucleotide sequence ID" value="XM_038190314.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046243.1">
        <property type="nucleotide sequence ID" value="XM_038190315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3F3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190314.1">
        <property type="protein sequence ID" value="XP_038046242.1"/>
        <property type="gene ID" value="LOC119720585"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190315.1">
        <property type="protein sequence ID" value="XP_038046243.1"/>
        <property type="gene ID" value="LOC119720585"/>
    </dbReference>
    <dbReference type="GeneID" id="119720585"/>
    <dbReference type="CTD" id="9917"/>
    <dbReference type="OMA" id="AVWEDDM"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="11">
        <location>
            <begin position="264"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="478" mass="54441" checksum="AE3716EF5F74850A" modified="2023-02-22" version="1">MVWLKRRRVLVLASIFILTWLVIIIYTPSPSGSQKNANHGAKRGASQQKPPQSGSRRSGKLPRIRIVDVDENPSIDKEEQKIETQLRDASQDFSDNKNLTFSKIKILDGENGDSKALLNIELDLIPHALPEGVRTQGAIWNLAGSWVNSKQITPADNPDLGMVLNAMANRPIVKADIGYKGTQLKARLELSGGQWVVFKPGRYTRDHVIDGTPYAGYDRHTGEIAAFHLDRVLGFHRAPIVVGRRINLRTEIKPVASQSLLNTFLNRGNQTCFYGKCYYCKPEEPACADEHDMMEGSLTLWLPRDKKLKKWHHLWSRTYRDNKKAQWEHDNNYCQGVLEKYPLEKHRHIMDILDTAAFDYLIGNADRHQYETFEADGDQAMLLLMDSAKSFGNPHHDERSILAPLYQCCKIRKSTWDKLLSLQDGRLSHVMRRVLSHDPLAPILTELHLQAMDRRLVTVIATIKKCLSDHGAEYVLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z452</accession>
    <name>A0A913Z452_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046492.1">
        <property type="nucleotide sequence ID" value="XM_038190564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z452"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190564.1">
        <property type="protein sequence ID" value="XP_038046492.1"/>
        <property type="gene ID" value="LOC119720738"/>
    </dbReference>
    <dbReference type="GeneID" id="119720738"/>
    <dbReference type="OMA" id="FMFHEDK"/>
    <dbReference type="OrthoDB" id="10006207at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36265" checksum="C791497DFAAEFC4B" modified="2023-02-22" version="1">MPGQEAPKSQGTQTGAIPFTLWLDPAYIEYVRSGLLVLVFLAAMWTRSRRTWILVDTVAVFAFGLAFMFIPDKLLGFQVESKVKIEGVMVMLCRTFGSFMIGSGFSWFFLRKSTDNYTQVMLLATRIVGNAALLIAMYVAKTQDKLLNDQFVRFGVLGAVLWTLGSALHFLMAKNYGGHTQLDSWLNLHLRIDFFLTLMFGLFWYAYPHLVIKMHAPGAGVKVNGIHVLVEQSVGAMLIGSAILSAVAPGFMFHEDKRNVLLCRILTIIMVVITALSSVDHSDIDKSAMLAHLVGVAWIINAGLGYFAPHETDGYWSSRKRANKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5A0</accession>
    <name>A0A913Z5A0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038046929.1">
        <property type="nucleotide sequence ID" value="XM_038191001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5A0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191001.1">
        <property type="protein sequence ID" value="XP_038046929.1"/>
        <property type="gene ID" value="LOC119721104"/>
    </dbReference>
    <dbReference type="GeneID" id="119721104"/>
    <dbReference type="OMA" id="ANWNTWH"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19854">
        <property type="entry name" value="DSRM_DHX9_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19855">
        <property type="entry name" value="DSRM_DHX9_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000026">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000677">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044445">
        <property type="entry name" value="DHX9_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044446">
        <property type="entry name" value="DHX9_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="389"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="633"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1189"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141134" checksum="EDCDC5B5BF0F6CD6" modified="2023-02-22" version="1">MGDVKNFLYSFCGRKKVTPNYEIKNSGPKHRQRFLCEVRVPGYNYVGAGNSTGKKEAQANAAKDFLMYLVRVGEVRESDLPVQSMPKPEESDGQPPSELPSGVALAPHLAVGDSAAPPQASSSFEQQGQREGGMPSYQRNFFDTRGEKRKLEESENVDLNAGIHGNWTLSNAKSRLHQYLQVNRLPGEYKYSSVGQDHNRSYVAELSLFIKSSRRTIHAREQGSNKKTASLSCALSLVRQLYHVGEIEAFTGVTKKRKIESLEPYNVTLVGEVEAKLTDALEQLNLPFVPEPTIQNEPVKLTSEKDDQTFENPEGPRGAYGVSWSPPQPNWNPWLNCNIDEGPLAQMTLEDVSNEIYQDSQHKLQDSRFQKMLGERHSLPIFESQQNIIDTITRSPVVIIRGATGCGKTTQVPQFILDAFIQHGKGAFCNIIVTQPRRISAVSIAERVAVERGEDLGISSGYSVRFDTVRPRPQGAMLFCTVGTLLRKLEAGLRGISHVIVDEIHERDLNTDFLLVVLRDMQRSFPDMRIILMSATIDTTMFSQYFGDCPVVEVYGRSHPVQEYYLEDIVQMLNFVPSANTRKSKNKSRDDDDEEEADDEFSENMNKQVSNQYSERTRNAMAQMSEKEMSFELIEALLTYINNLNVHGAVLVFLPGWNWIFALMRHLQEHPKFGNRGYLILPLHSQIPREDQHRVFESVPEGVTKIILSTNIAETSITINDVVYVIDICKAKTKLFTSHNNMTNYATIWASKTNLEQRRGRAGRVRPGFAFHLCSRARFEKLEDYTTPEIFRTPLHELALTIKLLRLGKIADFLGKAIEPPPLDSVVEAVAALKDMHALDQQEELTPLGKILAKMPIEPKLGKMIILGCSLFVGDAMCIIAASTVFSEPFVTHMGKVTNLHKSYCGIRHSDHIAVLGCFQEWEQALSNGGEDGAMNYCDRKQLQMTSLRMIYEARNQLKDILVMEGFPEQCMELEFFNFGGQDVKLEVIVSLLAMGLSPNTCYHKEKRKLLTTENKSALIHKSSVNFSKFEQTFPSPFFVFTEKIRTRAVSAKGMTMVSPLQLLLFGARSIESCNGLIMLDDWIQLRMPHASAAKITALRPAVEALIFNMTANPDSIMSPSPPDETLLNVIRELSSPRAGFFGNSQEDSGDQGQGRGPAGPSRFRFSNPPGYAGGRGGDRGFRGDRGFRGGGFRGARGGGGYGGGGNSRGGGGNFGGGRGGNFGSGEGNFGGGGGGNFGGGGGRGFRGGNSGFRGFGGFQGGRGRGGGGFRGSRGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6G9</accession>
    <name>A0A913Z6G9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nuclear receptor coactivator 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PRIP-interacting protein with methyltransferase motif</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047408.1">
        <property type="nucleotide sequence ID" value="XM_038191480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6G9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191480.1">
        <property type="protein sequence ID" value="XP_038047408.1"/>
        <property type="gene ID" value="LOC119721409"/>
    </dbReference>
    <dbReference type="GeneID" id="119721409"/>
    <dbReference type="OMA" id="MKYWVQR"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000066">
        <property type="entry name" value="Trimethylguanosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="600"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="797"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="925"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1197" mass="133306" checksum="ADFB0CEEF9226754" modified="2023-02-22" version="1">MAEHYYSQCVAELQFTMPPNPNEQRPQVSVRCTRAFCSDSKLYEWGLYGKPDPSKYKDLEAKELDTDEDELDRALTESDQLKSGDVITNQLDVVPELTTEIFQSESTGDDVTLCNEQYEYSSSNIRVDGKNISPYTKPSLPFQGEFASEQEVMRDMGLPLSFVRSLRDFDEDDDYMPKVRYGNKQANKKNKKKKKQQRVWSHDLDPSHHASETDVSHHASETDVSHHASETNVSHNALEAPEKEEQAPDTCVAPLPGNWSTVTSKEDECCHGDGIQATDVAEEADVDTGWKEYWETYGETLIWENWVQKYPDQVVGDGLIEASSMQSGGEHQLQDEMSEPVKNESNTNIVEAICAQDFPVSFDEATKFEANEILGSKSSLLRKEHTVTDLVATEHVSGSEIEEHLHQFQEATIQSVAEEMSTVSLEDCKTTSTMNVTNDSDSLTRVESGPTDDRKLSDQSAIFLKITGKGESFPNSCEELPDEFNGKDAARQDLENASTQIGNENSVGELQSNSCTRNGWTEEWSRLWDEHCGEVYWYYHQYYHTNIKNGVTENGEHGLPDCRTSQSEERTCSVADQSQLVLHSCADYSQSCEEVEDSSDCTANQLPSDESVHQSQASNTSGDAVDQSQRVNSCNGIDHNTEELNNSNGSNRDCDNSCRSDSDVDKEPFDGKSKRKKVSQKSQLSGDGANVSQQIGHGSGRLHSKGGGDGVGHGGDGEEPPEERPRQMKRSHELETDGEGGRDVLKRLGLSSDAESKKFREQERFSSVRVKYIRKNVSKKSKSLNMRKAPMHIWFDEEAGEASNGEAEIQRERSDGAESLKQVKKMPGSNTISKVKAFLSSQGEERSNQLQRKSAPLGETADNNASTENTERGSTEEQNATSTSVSLEDETKDSGVFVEQTLCWTSDQENSSAACGLQKDSAFEEITETESQDQESMSEASKAVTKENGNSSKNLPQDVGIREAGTSLGAPQNKKSTASSQDPRLAEYPEISSNPSMMKYWVQRYRLFSRFDHGIKMDEEGWYSVTPERIAKHQARRCRSDIIIDAFCGVGGNAIQLAFTCERVIAVDIDPVKIDCARHNAKVYGVADRIEFIQGDYFLLADRLKADVVFLSPPWGGPDYLQADVYDITTMMPLDAFKLFEKTKQITENIAFFVPRNANVDQLASLAGPGGRMEIEQNFLNKKIKTVTAYYGELVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6P3</accession>
    <name>A0A913Z6P3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046676.1">
        <property type="nucleotide sequence ID" value="XM_038190748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6P3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190748.1">
        <property type="protein sequence ID" value="XP_038046676.1"/>
        <property type="gene ID" value="LOC119720882"/>
    </dbReference>
    <dbReference type="GeneID" id="119720882"/>
    <dbReference type="OMA" id="NVGQMNA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1171" mass="101863" checksum="AE3D43E81A28CC9B" modified="2023-02-22" version="1">MDECAKFNELRECNCLRSESVQPSQAPDWTTIPPTVAGGDATTAAAVGDAATTATGEDATTAAVAIGDATTAAASSDTTTAAAGGDATTAASGAAGGDATTAAIDGEATTAAAGGDATTGGAGSDATITTAAGSDATTPAAVGDVSTAAANGDATTAASVGDGTTAAAGGEATTAAAGGDASTAEGGDATTAASGGDATTAAVVGDASTAAEGGDATTAASGGDATTAAVVGDLTTAAAGDDTTKASAGGDASTSSAGGDASTAAAGGDASTAEAGGESTTAAAGGDATTAAAVGDATTAAAGGDATTESLQPSHATDSTTVPPTVAGGDTTTAAAVGDATTAAVGDATTAPASGDATTAAASGDATTAATSYGATTAAAGGDASTAVVGYATTAAAGGDTTPAAAGSDATTGAAVGDASTAVAGGDSTTAAAGGGATTTTTGGEATTATEGGDATTEAASGDTTTAAASGDATTAATSYKATTAAAGRDATTAAAGSDATTAAAAVGDATTAAAGGDTTTSPTGGEATRTAGGHDASTAVAGGDSTTAAGSGDATTTTTGGEATTATAGGEETTAETRYGATTAAAGGDATTAAAGSDATTAAAVEDATTAAVGGDATTVAAGSDETTTTTGGEATTATAGGDATTAAASGDATTAAASGDATTTTTGGEATTAAASGDATTAAASGDETSAATSYGATTAAAGGDATTAAAGSDATTAAAGSDATTAAAVGDATTDAAGGDTTTSATGGEATTAAGGHDASTAVAGGDSTTAAAGGDATTTTTGGEATTATTAAASGDTTTAAAGGDATTAAAGSDATTAAAVGDATTAAGGGDATTAAAGGDDATTTTTGGEATTATAGGDATTAAASGDTTTAAAGGDATTAATSYGATTAAAGGDATTAAAGSDATTAAAVGDATTAAVGGEATTATAGGYATTAAASGDATTAAASGNATTAATSYGATTAAAGGDATTAAAGSDATTAAAVGDATTTAAGGDITTAAVGGKATTTLGDATTAAVGGEATTAAAGGDATTLAAGGDATTTGGFDTTKAAAGGDATTTAAGGEGTSVAAGASSTESLKPTQTLDSTAVPPTAAGGDATTAAASGEATTAATGDEATTAAAGGDATTSATGGDATTAAADDEATTAAADGEATTTAGGRKTFFLYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7M0</accession>
    <name>A0A913Z7M0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047727.1">
        <property type="nucleotide sequence ID" value="XM_038191799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7M0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191799.1">
        <property type="protein sequence ID" value="XP_038047727.1"/>
        <property type="gene ID" value="LOC119721858"/>
    </dbReference>
    <dbReference type="GeneID" id="119721858"/>
    <dbReference type="OrthoDB" id="10066781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="631" mass="70755" checksum="A9ACA6AF4DBF0043" modified="2023-02-22" version="1">MKYYCIAKESEIDTEDSFRNVKLESCLLMNDFAEASPLVKTVLVGMKQDKISQVVKQDPLIIQLGNAHSRTFGMDPQRRRHYVAQEMRLVARLMINLHEITQSNALVDDFIEPQKFDTVVRGVRLTSGQTDEIERPSVALKLGHTLSKLAAIKRCSALRRGDKKAEQEAKCFLKLKEAEWAEQISSEVLGKISQRKYNKVTELPESDDVKMFTSFLQENIEKATVNLEQRASAVNFRRCSELVLARLTTFNKRRTGETEQLALKSYTSRPNWDAASISDIKQYLTPLERHLMQELDMVYTRGKRGRKVPILIPAETKAAMDQLTTCRDVCGVPKENPYFFARPGCNTNLRACDSLRELTKEANLQKPHLIRTTKMRKYTATVSQILNLKDSQLDWLADHLGHSINVHRDYYRLSAPTIELTKVAKLMLAIDSGNVGKFVGKSLDEIDLDDIPVPDMDSDTEEAQVGTSEAAAGSTTHTRKKRGTGDVTDVRASAVSSPMQSPEPGPRPTGESNAAAGSTTHTRKKQRTGDVTDVRASAVSSPMQSPEPGPRPTGKSNGTAPKSRRPWSKSETSAVWTGLHEIIKCHRVPGKSECEACMEKMHPALNQRSWRDVKYKVKTILCGIERDKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA74</accession>
    <name>A0A913ZA74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048529.1">
        <property type="nucleotide sequence ID" value="XM_038192601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192601.1">
        <property type="protein sequence ID" value="XP_038048529.1"/>
        <property type="gene ID" value="LOC119722468"/>
    </dbReference>
    <dbReference type="GeneID" id="119722468"/>
    <dbReference type="OMA" id="AHREYLM"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13751">
        <property type="entry name" value="TGF_beta_GDF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF33">
        <property type="entry name" value="TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038033572" description="TGF-beta family profile domain-containing protein" evidence="8">
        <location>
            <begin position="32"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="321"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="48708" checksum="9FB594C252708375" modified="2023-02-22" version="1">MPFHAKESPSPVLVLVLCLLTLLVGAQRASGLPSPHHRTPAARAAGGPLDQSTARTGDPASRSSSTDSHSREERRLEAIKESILATLHMEEPPSPEVIARAKANLSPEDVERAYTEYEEKVRELSETDENIPTRTPIQTPRREIRQYHSVGSSRESVHFSRHLKPVTLFFGTGGAVSSSRRAEDVADGKLKLYLRPHPVGHTRHHTPRGKKVACSIFMVRRDNTTVKGRAVLEGSEIQLLDSKEVSLQSPGWKTFHITEAVRGWLDRTDGDAEELALVVTAGGRSADNLFYLEQGSGSTRTAAFQPRVDVLYREPPPVFNRERRQANHDYNCQPGDGVTTCCRYEQHVSYSELGWSDWIIQPTSYKSYQCSGGCPANFRSATAYSRIKSLMHTIDPDDWNAPCCAPVRFSPTVYLYMNGTGGFEVATQTDSVVEECKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBS0</accession>
    <name>A0A913ZBS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048491.1">
        <property type="nucleotide sequence ID" value="XM_038192563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192563.1">
        <property type="protein sequence ID" value="XP_038048491.1"/>
        <property type="gene ID" value="LOC119722442"/>
    </dbReference>
    <dbReference type="GeneID" id="119722442"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000008">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000820">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="882" mass="97546" checksum="85B8A519DB55200D" modified="2023-02-22" version="1">MASSISSHRALSSCTSTSDARPHHQPSSTVTAPPFSTTSHLDLSADDSFNEQSIGRVFGSRAGDQPGLQIDGEEDENQTHLSVVWHGGQLGAAYYDGETAEIHMMRDSAEPDTFTLLKQVFHQVQPKFIVTSATADERFLKAVKDLQGGKDTTSTVGDIRQTSSVSGPGTDGEPDSSMGDNQLQLLPSLDYTLEVCKRRILAMSLPSIPEHFTEEDRTIFFSSLIPFDCLCMVRAVGGLLKYLEKRRVGVELEGYNVRVPVLSIRMFSLEHIVSVDENTYSALQIFQKERHPSAYKSAGSGAKEGLSLFGILNKTKSVVGSKLMRVWFMRPSCDLALLTQRQNAIAFFLASVNTEVTSTLQECLKQVKNVARILKQMRQAQASVGDWQALYKTTYNAINIGDICRAQRADIEIFKKIARGFTEDLHYIASVISKIVDFDESAAQNRFVVKSNVDAELDHRKRTYNGLPDLMTQVAREELNRLSSDIEECNVIYLPQLGYLLAISCTSKMQQEKDFSVPGLEFVFLSNNMVHYKSASTKALDVKLGDTQCEITDLETQIMHRLQNSILERSEVLFTVMQHAAELDCLLSFAAAAKDQNYTRPDLTEDNIIHITGGRHPLQELCVSPFVPNDTYSGGKFGKMKFLTGPNASGKSVYLKQAGVIAFMSHIGSFVPAEGATIGMLDGIYTRVQTLESVSIGLSTFMLDINQMALALNNATAKSLVIVDEFGKGTEAVDGIALLCASLKHWLGRGTLCPHVLVSSHFHSIVKQSLLPQSQELTYQTMEVLQNGDEMVFLYQLIEGHADHSYASHIAAQAGLPEELLKRGKQVTDLLAQSKPIHRVNAESIDSQFQKCQDIADVFLKLDLEHTNVTEFLRDKILPNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZC40</accession>
    <name>A0A913ZC40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038048621.1">
        <property type="nucleotide sequence ID" value="XM_038192693.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192693.1">
        <property type="protein sequence ID" value="XP_038048621.1"/>
        <property type="gene ID" value="LOC119722525"/>
    </dbReference>
    <dbReference type="GeneID" id="119722525"/>
    <dbReference type="CTD" id="178"/>
    <dbReference type="OMA" id="YEEGHVH"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="130"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="710"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1561" mass="176530" checksum="17ABFD88AFBF97AB" modified="2023-02-22" version="1">MEVKMEEIRQLTLRDKEHKDTTLHRLQKGWKLHFVLGPSLQSKQVHVFTNHPPGHTPVQRPFNRGEFYELEWKTESSSRLDKSDQYCEVRLHLAGAFQYYFTHGTSNAPQGSGYFVVDPTLKLTSDTDILELDCITLQTVLTKCLGPLSEWEQRLATARETGYNFLHFTPIQELGASNSSYSIRDQHKLNPLFTSKGQQPVSNDDISALVVKLQYDWGMLSLCDVVWNHTSFDSPWLIEHPECAYNVHNSPHLRPAYVLDRVLWHFTLEVIDGKWTKHGVPSIIKSEEHIENIRSVLVDKVLPKYKLEEYYQLDVAATLDKFKTAAKAAKTVSSAEDSKEDDVKLIKDPKFRRLGGSVNMEKALQCFNIQRKDAEDEEDRLQKSCDAFKKHLLYWNNRAANEMSEDIRHALHNVCANVRYHRVDEHGPRCEKVTKNDPLVPKYFIHLGPNTDPTTEEKVMDSDKAPFLQIGNGWVMDADPLKNFAEPGSKVYLRRELIVWGDSVKLRYGETPEDCPYLWNHMLEYSRTMARMFHGLRIDNCHSTPVHVAEYFLDEARRVRPDLLVVAELFTQSEHVDNMFINRLGINTLIREAMNAYNAHDLGRLVHRFGGEAVGSFLQPRVRPLTPSMSHALLMDVTHDNQSPVMTRSVYDLLPTAALVCMACCAVGSSRGYDELVPEHIHVVKENRLYTSWKEDADVCHLEEVSHNHGIIKAKRVLNELHQTLGAKGYTQVYVDQVDENIVAVTRHNPVSHQSVILMARTAFKHPSNPSYTGYIPPLCVPGVVEEIILEARMVQKAEAPPPKSDTHINGLGHFTVDLQSNIQLYSSQMVELADHGSEKQSSVQEIDFINFPPGSVIAFKVTLNPASRKALSALRACISQFGYRVRTLSGNPPNQNQVTSNFHTIARKLSLADLNRVLYRCDVEERDDGKGSGGYHIPQHGSLVYCGLQGFMSALDKIRSKNDLGHSLCENLRQGDWMAQYVGNRLKLHASTRQLGQWFEAAFSNFSLIPRYLIPCYFDAILVGAYVTLLDLCWQSMSKFVFEGSSFTRALALGSVQMCGIVKTCPLPELSPKLSDVPTVTDEETNRREQCAVTMAAGLPHFSGGFMRSWGRDTFIAVPGLLIVTGRMDDAKYLILAYAATLRHGVIPNLLGGGSHARYNCRDAVWWWLYCIQLYCQGMEDGYSILECPVSRIFPGDEDEPQPAGFVDQPLSDVIQEAMQRHVEGISYRERHAGKGLDQNMSHEGFNVTIGVDHETGFPFGGSKWNCGTWMDKVGESDIAGNRGTPATPRDGSAVEIVGLCKATVRWLAKMHEAGHYPHSGVTVRLDGKLTQMSYKEWDAKLQANFEKNFWIAPDANKETNELINRRGIYKDSVGATQFWADYQLRPNYPIAMVVAPELFTPSRAWTALEMAEEFLLGPLGMKTLDPSDWGYVGDYDNSYDGHETKRARGFNYHQGPEWVWPIGYFLRAKLHFARRLTPDPSPSGAEPQDNLFQSTVNFVRQTLTRHHTEVELSLWKGLPELTNSDGQFCKDGCPTQAWSMGCILEVLNDCDKLLEDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE38</accession>
    <name>A0A913ZE38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050042.1">
        <property type="nucleotide sequence ID" value="XM_038194114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050048.1">
        <property type="nucleotide sequence ID" value="XM_038194120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194114.1">
        <property type="protein sequence ID" value="XP_038050042.1"/>
        <property type="gene ID" value="LOC119723450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194120.1">
        <property type="protein sequence ID" value="XP_038050048.1"/>
        <property type="gene ID" value="LOC119723455"/>
    </dbReference>
    <dbReference type="GeneID" id="119723450"/>
    <dbReference type="GeneID" id="119723455"/>
    <dbReference type="OMA" id="IANEWPY"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37777" checksum="41A5A53873D891B8" modified="2023-02-22" version="1">MMNETNLTLVEDDVGLRVIEGIAFVSITLLILTGNCLCLLVLRLARDMNHVTRVLLISLTAADLLMGTVVAAPVLGTVITHGWPYGYVFCAISASGNQICATTSLFSLLLINAERYICICRPLRYPSIVTVNRARVAVVCVWVFALFLGLSNCFLPGRIANYHEYLHSCFFDPLSGEPDVMGTLCVILFVFAPFPVLILMYIRIFVIARRHAKDMEARAIAMYEQAQRLSLQENGRVSLDQGRRRFFPEYKAAKTFGIITLTYAMAWMPFFSIVIYENLTMTKAPRGLTVTASCMALSNSWLNVLVYYARNAIFRTTAKRMLSGRRHRYSASSNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHU2</accession>
    <name>A0A913ZHU2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038050610.1">
        <property type="nucleotide sequence ID" value="XM_038194682.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194682.1">
        <property type="protein sequence ID" value="XP_038050610.1"/>
        <property type="gene ID" value="LOC119723810"/>
    </dbReference>
    <dbReference type="GeneID" id="119723810"/>
    <dbReference type="OMA" id="QEESTNT"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000006">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000018">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="955"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="1926"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="226"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1171"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1262"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1708"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1900"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1175"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1235"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1276"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1304"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1720"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1739"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="2290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2323" mass="252711" checksum="A0E5647C5EF569EA" modified="2023-02-22" version="1">MKQLRLCSDCAESNSAGAQPEGLEQRSLSTFCAAERSWSFEQGGTFSDNFGKNLSVSTARKSTEIRHCPEHNLLGWVCLRLGPPPIMADHIPSLHQSGGSSYQHQQRRTTRRGATATTSTVASTSINHYEALTSTHPAPVNKQTAKISNYKVTGEASKRKSEPLNLSIPAKQPAREIQEVKLNATIQFAHFGSALSSPSFITKYPASNEKTLPVELNAFDRHLTFESTSHSSSSTSVVSGQPLLNSNRERSRSRSRTTETKPAKEDHPHHPLLKDTRVCIPDNSSGKKRKASSSSSAGSSASSEATIGEKHSKLRLRAAHDQQESETREASLPGLSEEIPLITFRSLRSYSRDHPYQYEALDYYAPRRTPGRTSTQRRAAPPWGASTSTTVSSPPTTSASKSESKTPIGTSSTAAASSGTARSRASSLFSGLSNRSAENTSAESVGSGTHHTQPSTSGVSTRQKASRSRASSTPTSGVEEKGTALPVNLKGPLKGRATSSKGKSKARTSSPKPDSSRQRATDTNTGTCASTRSRRSSGMSKRGQSGASRSDTSSGRDTTAEGASATGRNANEDSAPGATATASGSGGGAPALALGGEGESDDSEVGRLQALLEARGLPPHLFNALGPRMHQLLHRSMGTGASSRAHQLLTGLQASGDESQQLQAVIEMCQLLVMGNEDTLGGFPVKQVVPALTTLLAMEHNFDIMNHACRALTYMMEALPRSSTVVMDAIPVFLEKLQVIQCMDVAEQSLTALEMLSRRHSKAIVQAGGLASCLLYIEFFSIAAQRNALAVAANCCQSIGSDEFNLVVESLILLTGRLQHQDKKSVESCCLCFARLVDNFQHDDKRLQQIASHGLLTNLQQLLVVSPPIVSTGTFIMVIRMLSLMCSSCPGIAVQLLKQNIAETISYLLMGSSEQASQEIELVPRSPQELYEITSLIGELMPKLPSDGIFSINTMIRKGNHQVPDSAIWQWRDDRGMWHSYTRIDNRIIEAAHQAGEDEVCLSTMGRTYTIDFNAMQQINEDTGTARPVQRQPNPACSASSAAANSTPNEDARATLLKEDPDLAALFIKALFAVLYEVYSSSAGPAVRHKCLKAILRMVYFAEADLLQDILKNHAVSSHIAAMMSSQDYKVVVGALQMAEILMQKLPEIFHVYFRREGVMHQVKLLAESPIEADSSPPLKPKTSTPSTSREASQGRDLGSADVGADFDTPPQGRLSDVLKWKRPPKRTVGRKSKYASNDDSSTSPSPFDVLEAHHTRLSSMAVTGAGKSTPTGRPSAAAKGKAAIGKNSGASQRSSFLSSLNPSRWGRSNSSGNGVTPASGNSNSSGSTPPSDKSSFSSSSRESGLHRAGSHHGHHHHYHQAADARAFGLDSHQGIGSGASVHLGTAGSSGGSSSQKEKVKQWIKEQANKFINQYFGVEMQGDSHPALGMLNKLCLAVDQLLLEKEQGIDCLQDIANILTNSDVSPFEILHSGLVSRLLNFLTSNSGREVLNRNTRLKRFLHVFLHCPLPNAAPIRAVDQLVTPPFVALVSKVNGCINHLEQFPVKVHDLPGGSSSGTRGSQALKFFNTHQLKCQLQRHPECTTLRQWRGGPVKIDPLALVQAIERYLVVRGYGRLRQEDEDSDDDASDDDIDESLAAAFSSSNMNIKHKLEFVINDRTLPYNMTVYQSIKQFGSMTEDDRDTDDESNPLGRAGIWIKTHIIWYRPASENSPEVSQGTPKSATSNSSNTSIGSGGGGASSSSSSSSTTKRGKGTGSSKAASKARKHDELWLDGICPTYISPLELYLTPKLPGGVVIDDPSVEAISLLRVLYGLCKHWNCLYEGAAPQPALSPSELTNSKLMAKAARQLQDPLVIMTGNLPSWLNAVARACPFLLPFDTRQMLFYATAFDRDRAMQRLQENNPDMNTSDTNERVAPRLDRRKRTVSRDDLLKQAETVMDDLAGSRAILEIQYNNEVGTGLGPTLEFYALVSQELQRADLDIWRGEHVMLLEAKGAQAGVKYVHSTQGLFPAPLSRSAKSQAVNKIKAKFRFLGKFMAKALMDSRMIDIPLSLPFYKWLLGKSESLNSYDLQYIDPVLARSFFQLEELMQQKKKLLEDSSHTPASLQLALDSLTIDGSAMEDLGLDFTLPGYGNIELKKGGKDTLVTIHNLEEYLKLVTHWTLVEGVSRQFEALRDGFQSVFPLSNLQSFYPEEMDQMFCGNSSEPWDIKTLIECCRPDHGYTHDSSAVKFLFEIMASYNPQQQRQFLQFVTGSPRLPVGGFKALTPPLTIVRKTFETSENPDNFLPSVMTCVNYLKLPDYSSSEIMQIKLRLAAEEGQLSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIE6</accession>
    <name>A0A913ZIE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050815.1">
        <property type="nucleotide sequence ID" value="XM_038194887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194887.1">
        <property type="protein sequence ID" value="XP_038050815.1"/>
        <property type="gene ID" value="LOC119723965"/>
    </dbReference>
    <dbReference type="GeneID" id="119723965"/>
    <dbReference type="OMA" id="CACAEYL"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="287" mass="32393" checksum="652A44A11C00BDA8" modified="2023-02-22" version="1">MSTEKGESSKTVDQSDMPEDKPQIGALSIKLPPFWPADPLIWFAQAEAQFHTRGIKREDTKFAHILAAVQPEIIQEVRDLVITPPKKNPYQKLKEEMIKRTSASEQKRLQMLLTEEELGDKKPSQLLRRMRQLLGEHKLEEGIFKQLFLQRLPSNAQLVLASSRDSVSLEQLAALAERILEVYVPPVNVVTTPAPSSSGELAELRDQISKLTMQVSSMQAQLKRQSHSRSQSRTHPRSASRDQASTPSDTANTQTLCWYHRRFGAEAHKCVQPCSYTTQQGNDPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJM1</accession>
    <name>A0A913ZJM1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051983.1">
        <property type="nucleotide sequence ID" value="XM_038196055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196055.1">
        <property type="protein sequence ID" value="XP_038051983.1"/>
        <property type="gene ID" value="LOC119724819"/>
    </dbReference>
    <dbReference type="GeneID" id="119724819"/>
    <dbReference type="CTD" id="25813"/>
    <dbReference type="OMA" id="SGIWRQI"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000002">
        <property type="entry name" value="sorting and assembly machinery component 50 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="9">
        <location>
            <begin position="153"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="52347" checksum="A1F4A655C6E01317" modified="2023-02-22" version="1">MGTVYAKEPVINEDAMSNTTDSEDPTEGPGTSPESRIQHIFHGDIKVKVERVHIEGLGRTKEDVILKHVSQLFKAETFKDVIFTSGVVKQELEELDMFQGVGVLIDTSKGPKARQDGLDVTVIVKESRRITGNAHTSVGNNEGSLVLGAKCPNLLGRGEHLTAEYSRGTRHSVGYNATFTTPLQGDIGKRFTATVFRTSGDFLSSSYKEIDHGTLLEVMLPSFLGQHSFKWEGNWRDISCLSRTASFAVREMAGHSLKSSIKHVFTRDTRNERIYPTKGYLLQISQELAGNRLGGDVQFLKGEAEIQLNRKLLKDCVVSCSLQAGLMKPLNYTETLINDRFFIGGPTSVRGFNFRGLGPHADGDAVGGEAYWAAGLHLFTPLPFMPGRGGLGDLIRTHVFVNAGNLCNLNLAEEQTVHQHLERLRDNFRWSYGAGIILRLGRIARFELNYVIPKTALHSDSINAGLQFGVGVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKI8</accession>
    <name>A0A913ZKI8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052308.1">
        <property type="nucleotide sequence ID" value="XM_038196380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKI8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196380.1">
        <property type="protein sequence ID" value="XP_038052308.1"/>
        <property type="gene ID" value="LOC119725015"/>
    </dbReference>
    <dbReference type="GeneID" id="119725015"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="39649" checksum="D735CA3245B0DDB7" modified="2023-02-22" version="1">MTGTTANTTPRTTATAVTSTANGTTAVMSTTNGTTVVMPTANGTTAVMPTTNGPTTAVKPTTNGSTAVMPTGNGTTAVISTANSTVITNTTSGTSTARTFPLSNTTKVTPGINLPTFYLEGVSGGVIGVCMLAVMEAELEIHYKTKNKTTLRTTIPVSYNARAFGYCGTSERKFTIGRNSATPPINSSAGITFIFHQPTETTYALSKLLGGWYYEEPFFDKDAVMYGKLGTLEMDMNLLSGTVGKTYKCHEVGYSWTIKETGMEGVFVFKKLIMFQPYADFSKDKGSFGEVEDCDRPKTTGMPPSTAFPTTRFLPTKPSSINVGMIVGIVVGTFALAVIVIGLACYFVRRAKKKKEVHVPYDQIVNSSVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKL6</accession>
    <name>A0A913ZKL6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051635.1">
        <property type="nucleotide sequence ID" value="XM_038195707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195707.1">
        <property type="protein sequence ID" value="XP_038051635.1"/>
        <property type="gene ID" value="LOC119724595"/>
    </dbReference>
    <dbReference type="GeneID" id="119724595"/>
    <dbReference type="OMA" id="LICELQV"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="122"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="245"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="11">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="893"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132807" checksum="16F8A8BD09D53A95" modified="2023-02-22" version="1">MPDFELRLVEEGLLGATRGLVQGRCGGRQKWGAICSNTFDLSTAGHVACRDLGQPPAISVGEVDPGAVYPGHAPDYTLFVDIGCVGDEASLSECEHYSLRQCESYATLECFNGTRDIRDIDIKLVNGRAPNEGRVLVRWSSDFEWTAMCFSLNYTEAVAFELCRWLGYPFVCGKEAAGAGRTDDPSLANISSVAYLTTCRSDPNDVFAGGCSLSATPDPVDETPCSHEQDMWLSCGFAGMPDFEMRLAEETSDSSRRLVQGRCGGIHNWGAVCGNRFAKQRAGRVVCRDLGLSNYSISTGALALGEVDAQLVPDYMLFVDIGCVGNESSLSECEHFSLRQCNSYFTVECFTEIREYAETAYLCGSKQLCGQECNQQIHPLPDSTDVFHYCKCDDACVLFDDCCFDSADVCDRIPPSLELGGFTADWFGCVWVLGSQFTHIGYVMVDRCPDDWRDGSMRSLCDKPVDATDVIGSMPVYDEQGVDFKNIFCALCNGRSLNRLNRWDVLGSDNGIESTVNTYYPSLNQTLPTKGWVSNPPENHTEIRKCPAHVIDTCLDEFRGTETERACRSYYAPIRADEKNIRYRNPHCAMCNGKVLVPDNSCMDQVCRDKCEPEPWGGCQSICSPYDDFFTIEVLFDFTSSSSINGRSCSEGQIYDPFLERCRVLTCAAGYRINGDECVAYTPADPPINGSKETSAIECWAKRLGKDTAGGQALLAGQTIIMKDPDADQLSALVLLTTAGEALDIVAAFDDALESIDNSTTLSELFCNISTLSILVPFAFAASSNCQTVNGNETFSGYVGNLFEVVRFQDIGHKIEYTKQRAEPLCLKVADLNCSSLLTLKGSEYMILADEILEVDVSGIRISEDEYVRFPDGSAVTCSFTEPLPEGLEQKIRRAISFAGSCLSLLALAATFVTYCIFPELRNTAGKSTMNLVVALFVAILLFLLTGYLRQSHVACVTGAVAAHFAWLAAFCWMTVVSFNVARTLASKVSRPRRGRGIDRSLVNYMCLAWGIPLIIVTICLALQFCNCTRLPTIYAESNICWITDANVRVVVFLVPVAVSLALNLTLYVFTVINFWRNRQLSKAARNQTTTDAVREELSVYLKICALVGVTWVFGFVSQSVTGIVVFSYIYILLNYLQGIFIFIAFCLNKRVRGLWRQKLRKMPAHTGKTNINPTPHHPKQQTDTMSSGMPGTSHSKKTTESTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKV9</accession>
    <name>A0A913ZKV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051725.1">
        <property type="nucleotide sequence ID" value="XM_038195797.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195797.1">
        <property type="protein sequence ID" value="XP_038051725.1"/>
        <property type="gene ID" value="LOC119724650"/>
    </dbReference>
    <dbReference type="GeneID" id="119724650"/>
    <dbReference type="OrthoDB" id="161570at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20386">
        <property type="entry name" value="Tudor_PHF20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF51">
        <property type="entry name" value="MBD-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="980"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1536"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1571"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1587"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1670"/>
            <end position="1690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1791" mass="196591" checksum="C0E435059D7D78EC" modified="2023-02-22" version="1">MEEESGVLGASGMLRQSPKDEDDEKTATSEKTSEEIDVEGDSDDEVQDVRPPSQEPQELEEKLEEADRSCPTQEVAVDENFGSGSVEKRSESGSPTDRQIEKQVCSPVEELQADASDKKLASGKTEQSVASEAKKTEVEKDHIPESKTTEFSEKVPESSSGETLKNPGDQQDVAKPDSDVLTIQEAPTVAQASEKIAERKTTHVPESKTTEFPEKVPESSLGETLKSPDDQQVVVAKTESDVKTVQKEPTVVQAKETIAELETKQIAKTQKLKSFEDAFKASLGKLNIEVPRRKTLIKRPGITLKPVDSASQRPPSETQQQRPKDSERITGLTDKGLNVMVPEKNETGPSSSSSSEKIPGGRPNASLDLTSSQKPARDNQKIEEDTSDDEGDNSRDVDNFSSDSSSTIIDIEMATKESTEEEIPGNLNKSRSTLQDQSSKEVLTDEVEKAKSRESNPTSDTRSRREASDKRMSSSTVPSRDHTRTRTIHRTHRTGVPTSVADKKQEIGSPSNTYPEKTREFSRLKSAARLRERSKSDESQNVLGKKYRISKHGIVLQPGIKLEAMDYSKKWYLARIVSVDETDSTVLIHFAGWNSRFDEWLEFDSDRLRPMARVSARRETAKEVKALGGYKVGDEVLARWSDCRYYPAKILGIKTNGSYRVLFYDGIEKIVMGINVRDMPDSLKSQQFFSNLEHQFRALLNKKRRGSKDAEGKSKGGRLSKESPSSSRPASPVQQPQKRRHPSASQTPATQPAKRSRQDSGRPQKLQKGYVMTTEPIPPSPTLPQEPTDLLPSPTSSEASELMSALEHGLMGNKKRYREPLIFDKTSGLIRDPRRIVAPKELVIDLDHNKYKCEVPDCGKAFRKASLLEYHNKYYHINKPATSTSAMTAAKNAVTRSRKRLSTSAMAPGSSKMRRTESLDVSPAKITSRPMRASAPSIMTASYKRPLPSPKLESPAETARPPKTIPMSSQFLKKPEVKQPLPTLRSERPAVKLDPAPPPPMAPTLPAPKTQGSEVIAKVVERSRRVSGSSVSKEDKPSTSKWEVVTTTIVEKPEAPPKAATPTPEVKIKTEPGVAPPAQKPETKLEESGTTNKNTEVKGQIQAPTEVTEVAAVKAEVPKKARRNKPHKKHKRHKARGRDRRSREQSRSERRRAAERAKQRRLEQRQLKEQFEASAAAAQKPEDVTEWTAKYLPITTGKNVTQSPAQSSDDPAAKPEAVDSSTTEDGGPRDMISCICRNQEEEGFMIQCETCYGWQHGRCVGLTEHTVPKQYICSFCIYPENLRTHARHRYDQEWFRTGRLPTLTQPAQPEEESSDLTDSMLKTHQLMADMINVTEALDGLQRKLEILKSDNHPDLKLWSHHWGLKDESTPLDDSAHSQQLQTSLEESDIHLTSADTSALTESMRSDVVIDSIAAEEVVMEVAGTGTSDANVESGSSAVGNRPDGGVACEMGQPQEGDKPMDGPNSPGASIQTSIPETRNQDPQKFGSDSVDTEASPMEVDTDKPLETSLSMQATKSKTEQNIEVGGGVPIVPDNSAPMSSKPQESQAESAPAEKSTACIVPDPEPSTTQGAKGGVTNEGGKPGIPVHDGKLDSTAKNVINDKTDLAKNAPTIDESGIPIQTTEKKDSVTGEQGELGAPKHHGKADGVAKQQARTDGNSSDDEPLIKYSKKTATSSETESESTSTAAKTTTPPLPQPSPAAVPVLVDISSSGQTVPASICKLNLFNHIVCVEEELKRRMDYVEEQIEALELAFNQSAGSKDSPYVPPDSLKMKQTISTLMVDLERVNKLVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN85</accession>
    <name>A0A913ZN85_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053197.1">
        <property type="nucleotide sequence ID" value="XM_038197269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN85"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197269.1">
        <property type="protein sequence ID" value="XP_038053197.1"/>
        <property type="gene ID" value="LOC119725724"/>
    </dbReference>
    <dbReference type="GeneID" id="119725724"/>
    <dbReference type="OMA" id="GKIFNMC"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="23">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="52761" checksum="544783A3637259C0" modified="2023-02-22" version="1">MSSPAEKHHQYKVRYSCITVEPVVLLFFISYSMIVTLRAEYVTLRIAKGLDDTKGSRAAVLAPDDTLCRLSNQSTDALYAETQSRASYWLLLLNLFQVVPSLVSAPLIGSWSDLGGRKRALIIPIIGYLIGSFVWIFVTYTNGKLWYLLLAEFCLGLTGDFSAVLAVCNAYLVDITTERERTFRLIMVGITIEVGTAASQILLGYWVVRQGFGLPFWFVVAAMLASLLYITCVLKETRAKSGGLENLELFNNRLLDDIYGMLMRYGSEKRRQMIFFITILGLHMMILYTAFLLVLLYVLSPPLCWTPVTVGYYVASALLLGSAGTLLGGKIFNMCVDDLGVVQMGALSFATSLILVAFSKSTMTLFFAGIFGSFRFLVSPAVRSRLSKLVDEEEQGAMFSLASSIESIGHLIGPLIFNLMYGVTTGFYQGFTFLVMAAVYAPICLMTGYYQVRGWMSNKTMSTNTEDDKERLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRC4</accession>
    <name>A0A913ZRC4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053944.1">
        <property type="nucleotide sequence ID" value="XM_038198016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198016.1">
        <property type="protein sequence ID" value="XP_038053944.1"/>
        <property type="gene ID" value="LOC119726360"/>
    </dbReference>
    <dbReference type="GeneID" id="119726360"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000031">
        <property type="entry name" value="RIKEN cDNA 5830411N06, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="232"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="344" mass="37205" checksum="CD80BB4FA735C884" modified="2023-02-22" version="1">MVTIDFRSNGWIPSAPADQWIQVDLGKPMVVIGLTMQGDDSVTCCHVTAFSVQHSLTAELDDWQSLANADGGAIRFTLSSGRPTNVTFPVLPMARFIRILPLAWVHQHYRVRFEVFGCQVPDGYVRLVNGTDASRGRVEIYHHDTASWGAVCANDWGINDAITVCRQLDLGAAIQANTASEYGRGDLPIMMSRVACEGTESRLVDCPFVCTDYQQCESSNVAGVFCYPKNTLRLEGGSNEFSGRVEIFRNYTWGTICDRGWDATDGGVVCRQLGYSGAVEAKSGAHYGEGSGLIHMEGVACTGSEEGLANCPSLCWTASTCSHSRDAGVICSVETSGSEETNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS07</accession>
    <name>A0A913ZS07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053862.1">
        <property type="nucleotide sequence ID" value="XM_038197934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053866.1">
        <property type="nucleotide sequence ID" value="XM_038197938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197934.1">
        <property type="protein sequence ID" value="XP_038053862.1"/>
        <property type="gene ID" value="LOC119726288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197938.1">
        <property type="protein sequence ID" value="XP_038053866.1"/>
        <property type="gene ID" value="LOC119726296"/>
    </dbReference>
    <dbReference type="GeneID" id="119726288"/>
    <dbReference type="GeneID" id="119726296"/>
    <dbReference type="OMA" id="THERREH"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="867" mass="97630" checksum="BA4C879A2BF5F8E3" modified="2023-02-22" version="1">MEPDQSSTSMVMQSLTQASEMDIFEMEGQSMADERDRLLEGTTSEAGDTIVVTAGEDEVAVVMMGESADADYRHSIDQAGDVVPLMSYSDNTMIDSTEAGDTTVVPPSESVDTMVLTSEAGDTMLVTTNEAGDTVLVPTSGTGDTMVFATSAAIDQTLLQPLDLTLPIPGKEVEDGTTVDAVEGGRADEGPADIISETQTGHDSDKELTDGQQGLHITNVDGREIIFICTHGQTFRCKPQAGTQISAAEKEQVMAITPCTCNKSKKPSQGHVQVAVQENDWPLRTRNQKFTCNKCGGRFTQKASLDRHMTAHESDEEGEKDTTEAEMDEADAQSKTNADQPSRKTRMQLRGSNTKALINECKVCGKVFSRLKDFERHEKRHQQYSKQKKTVGSKTKADEAMSKKEYKCSICGMVLENKYKLERHREEHLPSHPSGSLSCKVCSKLFVRPFNLKRHEKTHEEKHQASKLPKSFACKDCPKLFTRKVHLQRHEQLHVKETGMVFSCTLCTETFEDKFSYKNHSKTHTMKKYYREMTCEVCQKVVKGPITLKRHMRTHTKEKPFPCRIGCGSYFSSTSYRRSHEQYHCSAGPDLLCPFCGKVFENKARLITHETREHRDGLDEEGSARKRHTYPCRHCGRVFRFSAVRSRHERIHTNEKPYMCQFCPKAFCHANSLLCHERVHTKERPYKCTVCGKAFSQTTHLTTHMRVHTKEKPYECRYCKQAFAHLGTRKSHERTHKEALELKDIPQEDPKSQHILVSRFQGVSYQSAEENPVIQDSTMQANISTGNPEGTYQDIADPGLQETDHQELQGDPGDIPDSEMQDVTHRIILSHPEHEVQAADVILQLLQSGNRMANFDGLVHIVQSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS95</accession>
    <name>A0A913ZS95_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054638.1">
        <property type="nucleotide sequence ID" value="XM_038198710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS95"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198710.1">
        <property type="protein sequence ID" value="XP_038054638.1"/>
        <property type="gene ID" value="LOC119726855"/>
    </dbReference>
    <dbReference type="GeneID" id="119726855"/>
    <dbReference type="OMA" id="VNDHAEL"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="38610" checksum="F966AACEBCCC6492" modified="2023-02-22" version="1">MADISLIYRICETIIGVLGVLGNGLIITVIWRVPFMHTSSIAIICHQAIIDFLGSLLLLLQRNIPVPAQVPQTFGGELLCRVWIGDVTLFLLFVASTYNLLALTLGRYFNIVHPLRFRLMQSRKGVAAVIVIVWLLAPLIKTYSFLHYSVVDGQCNFRQLPASKVMGPLIICLQFFLPMVIMLYCYIHMAVALKRQAKLITLKTDDVGQDNTTAEVGRAAQMHQQHQLLKVRRDIFETLVVVFVTFVVCWAPSQVAYFMFNIGLLELDVKGPVHIISTIMTASNCCLNPIIYCFKYKLFRRAMRTMIGRPDNEQFDGLIQTAATNTTQNYNMQELKMTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT02</accession>
    <name>A0A913ZT02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054883.1">
        <property type="nucleotide sequence ID" value="XM_038198955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198955.1">
        <property type="protein sequence ID" value="XP_038054883.1"/>
        <property type="gene ID" value="LOC119727091"/>
    </dbReference>
    <dbReference type="GeneID" id="119727091"/>
    <dbReference type="OrthoDB" id="6159421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="287" mass="32747" checksum="7CD8011116368C41" modified="2023-02-22" version="1">MANFEFAAAVIIMGEVHKRLERTFQLFQNRDLFFQRVDKEVSSTISSIKRLPTRPMLKTELVDWLEQGKLHESGIVFSEEKWKDFIDQVATPFVDSVAANIKRRLPDSKDLECFKIFDPVQAAEHSNDPEYGFQEIETLATRLLSRAKAPGSHKEVTTAATNEWESFSYSLTSAEFEHKSVEQVLQKLVKEGMYDLYPSLSTMAATALTVPVSTAEVESLFSTMKRVRTPLRNRLQRENLSTCIRLSGFSPKPRTVNFGEMVRVFYTKNPNRRVECSDNKCDICGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXY3</accession>
    <name>A0A913ZXY3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038056348.1">
        <property type="nucleotide sequence ID" value="XM_038200420.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056349.1">
        <property type="nucleotide sequence ID" value="XM_038200421.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056350.1">
        <property type="nucleotide sequence ID" value="XM_038200422.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200420.1">
        <property type="protein sequence ID" value="XP_038056348.1"/>
        <property type="gene ID" value="LOC119728261"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200421.1">
        <property type="protein sequence ID" value="XP_038056349.1"/>
        <property type="gene ID" value="LOC119728261"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200422.1">
        <property type="protein sequence ID" value="XP_038056350.1"/>
        <property type="gene ID" value="LOC119728261"/>
    </dbReference>
    <dbReference type="GeneID" id="119728261"/>
    <dbReference type="OMA" id="QWTISGI"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275649" description="protein-tyrosine-phosphatase" evidence="18">
        <location>
            <begin position="32"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1404"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="319"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="414"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="511"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="609"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="714"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="821"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="919"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="1017"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="1118"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="19">
        <location>
            <begin position="1491"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="20">
        <location>
            <begin position="1667"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1269"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1369"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1432"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1432"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1848" mass="205366" checksum="F92C9A1376FBBA57" modified="2023-02-22" version="1">MSLRQRDSLSSNCLLICALVTLVWMSDLCVAVQPPVITRELQSEFGIEGGVIVFVCQASGDPEPSFRWEKGSRNAQNTRSEIFPMPSGSVLRIEPLRDGRDDAEFHCIASNIAGTARSTARLQVYTSTRIPAGFPVITRDPVLDVVEKGFPILLHCEAEGNPDPEIIWFKEYIPVDLSTERVKLTSSGLSISVSEFSDRGKYQCAARNSAGIRFSKTALLYVRVRRVAPRFTIFPETQEVVPGGNVNLTCAANGSPMPVIKWMKGDEDLSGPDDTLPQGRSVLVLKNVQETAEYTCYAMSDLGEIEHTVTVTVRTRPDSPPVPTLSQHTANTVTVQWIAGTDEPIKTYVLKYEPSSSPGAAKEIAGITVTEYTIDDLLPFTEYNVRVAAVNTIGRGDFSRALTVTTAQLAPSTAPREVRASPLSASTILVQWTAPETPNGIVRGYNIYYSNTPSQNLSFWYKHSVEDGTQRLTTISDLNPDQIYSIRASAFTAIGEGPASNAVQVITKQGVPSQPEMFVGEAISATQIRLTWRQRETEAQILYYELYYNDSKTGNDEHRSIPKAETYTLEDLKPNTVYNIRLAAKSRAGQGASTPIVSVRTEQAVPGAPPQDVKATTLSSTSLRIEWEPPPQDRQNGDVTGYKVSYVKVPRSGEVDTQDEMLLAVGPNDRSCVLVNLDKWTIYQITVLASTKIGDGPASRPISAETDEDVPEGPPRKVSVEALNSTTIAVRWSPPVLDRQHGEIRGYQVHFQVVSADEDPLGPPQVKWVPLPDIRENADEQEKILENLSPKTYYSIEIAAYTIKGDGERSRPKLVQTPGQVPGQPKRFVVERIESGDYHAHWERPDDTHGDLLMYKLSYQTSTSRPLYREIRPPATEFYPITLNKGQRYIFTLAAKNSEGYGLQAETDVITPEGKPTGAPQNFTGRALTSTSIQLSWSKPSDEESNGVITLYSILYYLEKEPGQEFTNDTVNTQVTFTNLKPSTQYVFKVRAHTGVGSGPYGTEVILVTPHPAPREAPRYVHAKPVSTTSILVEWKPPLDIDSSRPGLTYIVYYTSGSVDSNLDSWQRRVVGNFHSEEISGLEPKTVYAIVVQLQTPEGNSPRSYVERATTLKEESTAPDRFQAELKDGNSVKLVWDTPSSTDGSTTGYRIVYATSPQGQKEHPDHVDEGQSVTLTNEHRTFHISALKPNMEYQFNITAVTETGSSPPATVLVHTRRAAPNHVPIPEVDMALTTATTLTITIPPLDSRNGQIDNVLIVVVPLDGPSLPTGSPSDYSMDELLPSSGHRNQRDTSLRKRRATSNSLPYITAYLLASELTVPFTIGDERYINGFHNRPLEENRYYTFFIKARVLSEDEELLVASSDYSHPVQVKKRISTAPGGNNGTPEPNRSNPSKEPSDSSSMPAIIGAVIGVIILLVIIVIIIIFLRNKRRSGPTERRPKRKEVKSTNPSDPVEMRRMNYQTPAMMSHPPIPVMELSDHIEHLKSNENLLFSQEYESIEPGQQFTWDHSNLEVNKPKNRYANVIAYDHSRVILSRVDGLPGSDYLNANYCDGYRKQNAYIATQGPLPETLGDFWRMVWEQRTCTLVMMTKLEERNRVKCDQYWPSKGHETYGDIQVTLHDMTDLATYSVRNFSLINIKKPAEKREVRQFQFTAWPDHGVPEHATQVLAFVSRIKACNPPDAGPIVVHCSAGVGRTGAFIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYIFIHEALLEAVLSGNTEVPARNLYSHIQKLTQTEPGETITGMESEFKRLANQKALPSKFVSANLPANKFKNRLVNILPCMYFPVISPNHSETITLGVSGASKCRIDSVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY19</accession>
    <name>A0A913ZY19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase/reductase SDR family member 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055951.1">
        <property type="nucleotide sequence ID" value="XM_038200023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200023.1">
        <property type="protein sequence ID" value="XP_038055951.1"/>
        <property type="gene ID" value="LOC119727943"/>
    </dbReference>
    <dbReference type="GeneID" id="119727943"/>
    <dbReference type="OMA" id="ETWAINY"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19512" checksum="9B4C89230C08935C" modified="2023-02-22" version="1">MECVEDREALHGVAYKGTGESGDSCPGPTGRADDAGHVNGDSIIMALEDWAVALVVIGSVLAVMCLLSFVYYWFVLRYRVASSSVSMKGKTIIITGASSGIGKATALGLARRGARLILACRNEEKTAQVISEIKQKVPQGPEILYRHLDLASLQSVRKCAEQITREESHIDTLINNAGRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYK3</accession>
    <name>A0A913ZYK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056390.1">
        <property type="nucleotide sequence ID" value="XM_038200462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200462.1">
        <property type="protein sequence ID" value="XP_038056390.1"/>
        <property type="gene ID" value="LOC119728282"/>
    </dbReference>
    <dbReference type="GeneID" id="119728282"/>
    <dbReference type="OMA" id="ETFRKPH"/>
    <dbReference type="OrthoDB" id="5804096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="215" mass="23930" checksum="64017E8BE2BC4068" modified="2023-02-22" version="1">MESLDIQHVRRKTVHVAEPYFGVNSMSVQLIYRQFLAATFMMGLFLCSFAEGSEDNVKCNNLQIGQYVCEDPVIDPETQAAVNCLPERLVTVSCMPVAGTQCDGEIYNGSTVAPDLKRMVPCRYTTGYSYNTSLLLSIFLGMFGVDRLYLGYPALALLKFCTVGLLFIGHFLDVILIALQVVGPADGSDYILDYYGPVLQKSNLDNYTYYMPNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0E8</accession>
    <name>A0A914A0E8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="20">ETF-QO</shortName>
            <ecNumber evidence="20">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 20">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="20">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="20"/>
    <dbReference type="RefSeq" id="XP_038057065.1">
        <property type="nucleotide sequence ID" value="XM_038201137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0E8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201137.1">
        <property type="protein sequence ID" value="XP_038057065.1"/>
        <property type="gene ID" value="LOC119728760"/>
    </dbReference>
    <dbReference type="GeneID" id="119728760"/>
    <dbReference type="CTD" id="2110"/>
    <dbReference type="OMA" id="INFQNCV"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000088">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 20" id="KW-0813">Transport</keyword>
    <keyword evidence="17 20" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="606" mass="67037" checksum="417C0B6F0F4C061F" modified="2023-02-22" version="1">MALSSSHLCRVACRLARTSKSLYSTTSTPKITTHYTVIPREKDERWKDVEMERYADEVDVVIVGGGPAGMAAAIKLKQLSNEKGTDLRVCLVEKASEIGGHTLSGACVEPRAFEELIPDWKEKGLPFHTPVTKDKFAFLTEKRRIPIPIFKGLPMYNHGNYIVRLGNVVRWLGEHAEELGVEIYPGYPASEILYHEDGSVKGIATSDVGIAKDGSPKATFERGMELHAKCTIFAEGCHGHLAKQLFKKFDLRKDCQPQTYGIGLKELWEVEPSKHHPGLVEHTVGWPLHKDLYGGSFCYHLDEGAPLVSVGYVLGLDYSNPYISPFKEFQKFKQHPSIRPMFEGGKRIAYGARALNEGGLQSLPKLAFPGGMLIGCSPGFMNVAKVKGSHNAVKSGTVAAEALFDKLTQENPTSETQGLYVEEYEPRLKESWVWKELYQVRNIRPSFNNPLGIYGTIMYTGLFYFLGRGMEPWTLKHPGRDSEALKPASECTPIEYPKPDNEVSFDLLSSVALSGTNHESDQPAHLTLMNDSVPVECNLGTYDGPEGRFCPAGVYEYVPTEEGEGMRLQINAANCVHCKTCDIKDPSQNINWVVPEAGGGPAYSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1N4</accession>
    <name>A0A914A1N4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057544.1">
        <property type="nucleotide sequence ID" value="XM_038201616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201616.1">
        <property type="protein sequence ID" value="XP_038057544.1"/>
        <property type="gene ID" value="LOC119729100"/>
    </dbReference>
    <dbReference type="GeneID" id="119729100"/>
    <dbReference type="OMA" id="HINAGHA"/>
    <dbReference type="OrthoDB" id="16287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043516">
        <property type="term" value="P:regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="366" mass="40980" checksum="4D127226138547CC" modified="2023-02-22" version="1">MLRNGVIMAVINLEGFERRYINDCVGYGLFTTKHFSKGDFLLEYRGKLRKGNCNNDNDYTFFFNHQGVEYSIDNAMNPNSCMARWINDAKDTPNCVMKKLVFESCDEPHLCLFALFDLEVGSELRYNYGIDNLPWRQTKWKQDHSDNDCPCQLYSPSFHDEPQQSHINAGHAAQMPSKLSIAEPHQSHIVSGGPHCLKKDVQAADQMPSKSLDEPQQSHIVGGPHCLDKDVQSADQTPLKSSLDESQKSHIIVRKHAPSYPVEDSLDSPDEYPSDEDDPDFIPDSNSSDEDIVPESSDEISLRSPSPVIPIPSRESSNHPVSSDETVSSTSEIEVMTTSNSEGSATGTNHSTAHFVFSNRRNYHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1X1</accession>
    <name>A0A914A1X1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057826.1">
        <property type="nucleotide sequence ID" value="XM_038201898.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057827.1">
        <property type="nucleotide sequence ID" value="XM_038201899.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057828.1">
        <property type="nucleotide sequence ID" value="XM_038201900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1X1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201898.1">
        <property type="protein sequence ID" value="XP_038057826.1"/>
        <property type="gene ID" value="LOC119729287"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201899.1">
        <property type="protein sequence ID" value="XP_038057827.1"/>
        <property type="gene ID" value="LOC119729287"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201900.1">
        <property type="protein sequence ID" value="XP_038057828.1"/>
        <property type="gene ID" value="LOC119729287"/>
    </dbReference>
    <dbReference type="GeneID" id="119729287"/>
    <dbReference type="OMA" id="IYGQTAC"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="211" mass="23588" checksum="BDC946C99D9360EF" modified="2023-02-22" version="1">MDGPIMSEVHEAAAAGDSEQILNLLNLGKYDVNQKDAEWHDRTPLHWAAIKGHAESIRVLVDYGANVDAVTDSGWTPAHFAAEIGKISALKALHKLGANVEIQDSCGDTPRDVATVYGQTECVEFLKLAEYEDRIQRERDKQEKLEREERERQDEEKRRREEELRMQRKQEAEKRAKEKGKEKGKKGGGNNGGKGRNLASVGKAILLMGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2G6</accession>
    <name>A0A914A2G6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057840.1">
        <property type="nucleotide sequence ID" value="XM_038201912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201912.1">
        <property type="protein sequence ID" value="XP_038057840.1"/>
        <property type="gene ID" value="LOC119729297"/>
    </dbReference>
    <dbReference type="GeneID" id="119729297"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098660">
        <property type="term" value="P:inorganic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="663"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="76290" checksum="EA9EF6EA64129A6E" modified="2023-02-22" version="1">MDCSASTCTRSISRLSATSETVFCVSRTLRVLLKSVRRLSLKPLHIFINLYRAIRVTFHRLVRHIVSSISSYNMAKVNTTFQTADYLVCASTLLVACGIGVFHACTGGRQRTSAEFLLADRNMSPFPVAVSLVASFISAITFLGTPAENYTQGCMYWLYAISYIFVGLWTSRCFIPIFYRLHVTSAFEYLELRFNKVLRICGMLTFFLQMIIYMGIVIYAPALALSAVTGLHLWGSVVAIGLVCTFYTTIGGMKAVLWTDVFQVTIMISGFLALIIAGSMRMGGIGKVWEVAEAGGRIDFFNFDPDPTVRHTFWSVVIGGTFTWSAVYCVNQAQVQRYLTCGREPVAQFALFLAVVGMVIVVSLACLAGLVMYANYAGCDPFTLGYVDSSDQLVPYFLMDLFHESPGLPGLLVSAVFSAALSTVSSGLNSLAAVTGEDIVKTISPDIEEEKYTKITKALAAGYGILCIGMAFVASLLGDVLQAALSIFGMIGGPLLGLFSLGIFFPWANSKGALTGLICGLVFSFWIGIGAQFYPPPNPNKPLLSIDNCPNVTEASLNATFYMTTELPYTMAKEPERPHVAQLYAVSYAWYSAIAWLTVIGTGLIASFATGYTEPSEVDPRLLCPVVDAMYCCLPEKWKGPLRCGAKKYEPGDDQEKVVTMKETEEYKSEQDGQGAFSQVVTDGDPPAYDEAVDQLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2V4</accession>
    <name>A0A914A2V4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057990.1">
        <property type="nucleotide sequence ID" value="XM_038202062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2V4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202062.1">
        <property type="protein sequence ID" value="XP_038057990.1"/>
        <property type="gene ID" value="LOC119729492"/>
    </dbReference>
    <dbReference type="GeneID" id="119729492"/>
    <dbReference type="OMA" id="TIYRMEM"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037846627" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="13">
        <location>
            <begin position="18"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="511"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="820" mass="93026" checksum="E07C2597D4D97C2E" modified="2023-02-22" version="1">MHATRLLSYLFVANTVALFQANGATFDPNTSATVANTTSDPLVSGQRTPIYIGGFFAFPNNSIFGALPRTVQTAIDHVNNLTGILDGYELRMRFRLTNGKPNEALELLNDLLYEGPTLLMSWGPILSRQALVVNEVAPYYNVVQVCLANSQALRDRTRYPLTVQMYWSEDSVNPARVAFMRYMAWSRVAIIFEDNEYFRLNAEDLRAKLEAERVTVIAIEAISDAGKPEQQLLSLKRHDARIIFALSYFDTAIKLFCTIYRMEMFGPRYAWILVGWYPEEWWMAVNDDDCTAEQLEKALGYHFSVPAWRSVDNLDEINYGHIKPPDYQLDFLRGLLSREGVDRLEHIESYDSLIHIAMSLNRSIEKLASLEPARALHDFSYTDREMSGVLLESVYQTRFVGPTGSVLIEHGGFRLENNVRFFIAQFQDGKSTEIIEYHNESTTFREVQNRRFRWPDGTPPVDGKTLIDQKDTIGPPVRLTFFIFTSSGIVLDVAFLYINVKFRKERAIKISTPPLNNLIVLGSLMLYASVFLFGVDQSDFTDTEIIRLCHIKLSLVCVGISLAFGALFMKTYRIHAIFSRAVAKLKRVALPNSKLILGVFLAVAVDIVVFTIWILFGETYVAETRSEPRLDVSRPGEEIYIVSVIPYCTSDYVSYFMGVIYATKGILLMFGIFLAWETKKITVSSLNDSKYIAMSIYVVAIFLAIVLPLLNLHVVRQNVTIEFAILGSAIIITNTTVLCLVFLPKICLLYKVGRANFHVSMMMTRFPSNHSTATFSDYASASSVKLQEKLQQKEVLLERLKQHLAIVVASLHKRQQITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A308</accession>
    <name>A0A914A308_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057984.1">
        <property type="nucleotide sequence ID" value="XM_038202056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A308"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202056.1">
        <property type="protein sequence ID" value="XP_038057984.1"/>
        <property type="gene ID" value="LOC119729488"/>
    </dbReference>
    <dbReference type="GeneID" id="119729488"/>
    <dbReference type="OMA" id="FNGDVEH"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051253">
        <property type="entry name" value="11-beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279:SF2">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="33308" checksum="CDC283B9FB9425B9" modified="2023-02-22" version="1">MGWIKYLIAIFAGYIGFLLVGRFDPESINGKRVVITGASTGIGEQIAYQYASLGARVLITARREAVLQQVVARCKELGAQEAFYLPLDMGKENDTRRLIDEAKARFGGLDHLILNHITNNYMSLWAGNLEKLRKTMDINFHAYVSLATFATPMLAESKGSIAVVSSVAGKAGVPFVADYSASKFALHGFFDTLRQEYQMQNMGISVTIFVIGSIDTPNAREYSKKVMASGLFFTTSSSTGYRIMTGTANREREVFYPAYETLFAPLLRDLAPRVLEAIMKLTFNSDFLDEILKNPQPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A356</accession>
    <name>A0A914A356_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MICOS complex subunit MIC13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MICOS complex subunit Mic13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058268.1">
        <property type="nucleotide sequence ID" value="XM_038202340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A356"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202340.1">
        <property type="protein sequence ID" value="XP_038058268.1"/>
        <property type="gene ID" value="LOC119729671"/>
    </dbReference>
    <dbReference type="GeneID" id="119729671"/>
    <dbReference type="OMA" id="YLQQMPS"/>
    <dbReference type="OrthoDB" id="5948578at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026769">
        <property type="entry name" value="Mic13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816:SF3">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15884">
        <property type="entry name" value="QIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="109" mass="11252" checksum="9E8B9DEA5CDEA808" modified="2023-02-22" version="1">MAVAIVKGLGKLAVGAGAVYVTVDQGIWSASSEGASSLRNLTAAYTIPSQQEYLQQMPSAKGIAAQLREGWNSGVKSTFGYIVAAPEKVEDLASSTSNWIADSVAGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4I7</accession>
    <name>A0A914A4I7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058738.1">
        <property type="nucleotide sequence ID" value="XM_038202810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4I7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202810.1">
        <property type="protein sequence ID" value="XP_038058738.1"/>
        <property type="gene ID" value="LOC119730020"/>
    </dbReference>
    <dbReference type="GeneID" id="119730020"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037608291" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="296" mass="32489" checksum="FB35FA89D78B48C5" modified="2023-02-22" version="1">MAPLILWSFLAFGLGVYMGVVESQLRTWYFGPPPKPLPGEHWMQAAAREIRKRCPGTRSSTEVSDEAEATLAGEISTTPSGPRYAGCSESLDSGTGGTGVGVVTIYPSQYPNGTTVYCRLDWILIQRRYDGSVNFTRSWAEYRDGFGDLTGEFWLGNEIVRQLTSEGTWELQLVVKDASRGISFIPLGEFQIVGDNYALGLKDISFANVQVGQWFSTYDRDNDADGNANCAAQLKGGWWFTTCTGGVGNVDLVPINLNGEYSYPVTYTGQDYRGVRWAGLANGQIISCALEIRPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4U6</accession>
    <name>A0A914A4U6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058872.1">
        <property type="nucleotide sequence ID" value="XM_038202944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4U6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202944.1">
        <property type="protein sequence ID" value="XP_038058872.1"/>
        <property type="gene ID" value="LOC119730163"/>
    </dbReference>
    <dbReference type="GeneID" id="119730163"/>
    <dbReference type="OMA" id="ITWHINS"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037541355" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="140"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="539" mass="59705" checksum="303D99D32F8F74DE" modified="2023-02-22" version="1">MMSASMMSPIGLVFVMLLYTAEGVFTIHPRNQTVYEGDNVTLTCGSEYMTQCNYQRFYWCRSTTSHPAQQYVSGCIQVVPSLRNRMTVELDVLTRVFHLNIQNVQLQDGGQYWCQLFYAQNSHLNKNSSKATLTVIPRPPPSCMVTSPSNPRVGDNVSFTCTLAGSDPSAAITWHINSSSGHRPLTSIQEVREGRVSRVNRVLQATDNMKEFVCVAGLDFNTGPRCSVTPLQIPTRVSISPTFQSVYEGDSAVFTCNVRAIPPLTDEEYRWRIYKTDESEVTVTGATLTSFDGRYNMMGNTLEILAVSADFHNSYITCTAIYPQDSSISINRSLLTVLSVTTVLSATSSTATATVQESKDPSVLQTEETHFGVKTPDHYSTSVRTTITNELKEEDDTCLCQIIPIGVLIGGVLALLLLLVVIILLASFLLRYKRKVRRLRQTLAGNPVQISAIGSSEGMDLTYQSLQKDVGNQGATELTYMDLNLQQGEGNQVRPQAESEVSYKNLPRNDPSYPDSSACRERPEDMAENETGLYENISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6N1</accession>
    <name>A0A914A6N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sphingomyelin phosphodiesterase 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059463.1">
        <property type="nucleotide sequence ID" value="XM_038203535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203535.1">
        <property type="protein sequence ID" value="XP_038059463.1"/>
        <property type="gene ID" value="LOC119730561"/>
    </dbReference>
    <dbReference type="GeneID" id="119730561"/>
    <dbReference type="CTD" id="55627"/>
    <dbReference type="OMA" id="EERGKIH"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050290">
        <property type="term" value="F:sphingomyelin phosphodiesterase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14724">
        <property type="entry name" value="mit_SMPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="97243" checksum="D6E2B44E6E0BCFE6" modified="2023-02-22" version="1">MAASLFGANLTFSSTSSISSLPRSTDILDACNKPMRQRCEEIASFIHRSSSKELHSVYPQLLDNIFGYNQNPGWGLHVVTQQTSRDDYRVLQEFMSPRGPLMLMVYKLQADGVLRYEFPVSSLPAPTRDAILEGAMPGLYAHKLSYQTQGRLPSTISLNAFEYFMYSFAYLIVFRHKQQSLQQWTDADDWLYPSLLNDYLHHFLPIDGSSVPPAPFTSGTQTPTPGQGHSPPYRLPQYGVLYHYLYSGGSQHNQLFRNDVASGMAHHQHPHQHHQPLFNLAQSAPMDYSNQETWRSETFLQALGEFWLSQNALQPKEQGFRQHVRENYIPSSDHVRVVRILVKHLHFFVNSARPPLAITAYQQPEQGQLEDFKRYVIPQFIQKKLYVFLRHGFDNWPLDSTFRQILEVWLSYIQPWRYTEQTREDERSPVNMRDTARDRPLQEERWLKFVSSNLLFYTVLFQEFLPRAFRQDLTGPKNAIVLFRVAKVFAQSNLAQVLEEAERRLVEDYHSPVRGRSGSFGSSFISHQRVPSSLDLGSQIAELEAPGFAYWPLFGDEVKSGIERLLQTVHQAHITVSNMNYSPIANPDEGFFSWLGFSDLTSEGQGSYGHYHHHQLQDDIGPGDIRKLSRYLECTADYLCKIFQVSAPSITNGSMDGGSSGGVGSQQNGQPPHCIEGKLSPLGRYQLMNGLRRFEITYQGDPDLQPIRSYENAFLVRRLYKLSTSINDTFGNKIQELYHRPDFTGAVAKQFFTPPTVTPTHRQTPKRTLSYSPTPARSSSGTQQYRPRVSLRFLASHYTLAKLVVFFLCLWLMGFGPVGAVFMLVIAVALYGVIGGTMYTFGHDKETHEHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6P5</accession>
    <name>A0A914A6P5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059149.1">
        <property type="nucleotide sequence ID" value="XM_038203221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6P5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203221.1">
        <property type="protein sequence ID" value="XP_038059149.1"/>
        <property type="gene ID" value="LOC119730364"/>
    </dbReference>
    <dbReference type="GeneID" id="119730364"/>
    <dbReference type="CTD" id="5928"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="430" mass="48445" checksum="E7729043DE813795" modified="2023-02-22" version="1">MADKEQVPEPFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTSQWLPDVRRPEGKDYSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPTIIATKTPSSDVLVFDYTKHPSKPDPNGECKPDLRLRGHQKEGYGLSWNPNLSGNLLSASDDHTICLWDISGDEKDVCVVDAKTIFTGHSAVVEDVSWHLLHESLFGSVADDQKLMIWDTRVNNTSKASHSVEAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHRDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPGELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEEPDTPAAELEPPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6S8</accession>
    <name>A0A914A6S8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059465.1">
        <property type="nucleotide sequence ID" value="XM_038203537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6S8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203537.1">
        <property type="protein sequence ID" value="XP_038059465.1"/>
        <property type="gene ID" value="LOC119730559"/>
    </dbReference>
    <dbReference type="GeneID" id="119730559"/>
    <dbReference type="OMA" id="GSEHRCA"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037633689" description="Farnesoic acid O-methyl transferase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="28175" checksum="C698BD08BA39ADBC" modified="2023-02-22" version="1">MKVLQVILIAVIFCAEFSISNGSAPVKYSSNFGVSGHGNDKTVPRAQRVISSSVAGSEHRCAVKCLKNDRCWQFCHVATSGLCVLQDASLVQKSGGPSKVDNCTYFTRKVCNSTYQLKSRQKLFAFPAFNGNEFVLDFAVQADQAAKIVLSTDGTGGGIKYHLVLGQTGNTRTTIRRCFSCYVLKLVSTPGVLSAHKMRRFWLRYDHGTFALGKHQQAAFFEWTDPTPQDIPMRFFGFVSYNTPQIWAAYHTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6X1</accession>
    <name>A0A914A6X1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059612.1">
        <property type="nucleotide sequence ID" value="XM_038203684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6X1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203684.1">
        <property type="protein sequence ID" value="XP_038059612.1"/>
        <property type="gene ID" value="LOC119730690"/>
    </dbReference>
    <dbReference type="GeneID" id="119730690"/>
    <dbReference type="CTD" id="84057"/>
    <dbReference type="OMA" id="VCYWAFP"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398:SF0">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="10">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="11">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="205" mass="23759" checksum="0C7C1B255179FF59" modified="2023-02-22" version="1">MSRKRGLSLEEKRQRMMEIFFERKEVFQLKELEKIAPKTKGITSMSVKDVVQSLVDDGMVDSDRIGTSNYFWAFPSKASNARKRKISDLSGTLDESEKKRAATKKLIAKATVGKEDTDDRTELLSTLAEQEQENSRLKAELEKYRECDPEVLEEVKKQTLVARDAANRWTDNVFTIKSWCKKKFSMEEKTIDKHFGIPEDFDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7A8</accession>
    <name>A0A914A7A8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-secretase-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059306.1">
        <property type="nucleotide sequence ID" value="XM_038203378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7A8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203378.1">
        <property type="protein sequence ID" value="XP_038059306.1"/>
        <property type="gene ID" value="LOC119730461"/>
    </dbReference>
    <dbReference type="GeneID" id="119730461"/>
    <dbReference type="CTD" id="54103"/>
    <dbReference type="OMA" id="CHIVCAP"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="2">
        <location>
            <begin position="892"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1138" mass="128867" checksum="93959A7CADC0D60B" modified="2023-02-22" version="1">MENLCNFSCCFDVKKDISGFINTLRSPEAAANNSSDGNAKRKKDKSELDVRIIGQERFNEVLYVWDDVSSFSNKAVTHVGLYDPAKQKNSVLFVHEKKLNIISCTMNQERSMIAYVTLEGPSKSDSYKDSTKQKTKTKISPFVVYRAFLAEIFPQHRIFDLNVERRNLLRVQFLWNRQPKDRDSANRESKLLFLLHKESIGLYSLPLARMGNKGVMMSGPPDTLQVLKQFIWAQWDVVNQRLFVVLMKSWPGNEKLVPIMRCLEFNSKTSPVTKILELVLPFPIKFSAGKEQYSDVTPSRTMSESSFNMEVIVQAGGSFCVCYQHPTKPKVKTPPTHKSYPKISTVHTSERLSTDSDTDSLADSVEQSSSLPSQMDLRDPPQPDTRRRAISDISSFSPSAPYIKEETLHNAENLELSSDLSSITSSTEVVHHPLHLDIHRATQHTQSPRESPRTPSSAFSSPMMWGERELPSPLPNAEKQDLVDLNYSVLILHHMTVLHCSVPQIPRALAESTKLYFTCLGSYILVYSPGHMLHLLNVSPEIVPCLHIAFHGPSVPVNPVIENNGEGSSAFWDSSKGCQILTHFNRERTGSMSGDCIFNAATGKVFRVSINKDVIPRLLIQANCHSVKLALIHLITVHIRDSVLIQKFMKELSMDVTNLDLSELMAEHLMGATFSAIRRQFDRDTLRLLQFTNTDTTRGQLVETTDGERLVSFRHAGYNTQPQVNVHKRDWMERRLTMEVSSSTLWETLEQRVRAHSLPSDPTIVSKPPQRFHPRSIEQEIRKQRTQSAIGVGLTRQGPSTQRSSFFKKMAASARRAMTPTKKSVITMQPERDSSLVLMDEDASRPDNSQDGILSMTSERLTSHLSLYSASSVSHEKILNMSQEYVMCQLQQVRQLVLLMLHSCGYPDPRTIPRSTIRLNTKPPPMGYQLFRLLERFYMAVQSLCFPVPPGFQTFFTIQGFRCLEPAMFLQYVDHGILRLTEEFMTRLMQEVPDDTEEQVNMKIQILTRLPKGSVQVLQRWNHPISMEYLAQQYVAETLKEEGVRTSDYRTRSSRSASQNSQSSGMSDGSLTGIASTFPPLSTLLRLLEAKDPKVWSTIKSSDDNSPIVHHLDTKLVERVALRQSVEQYGSDLSAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8E5</accession>
    <name>A0A914A8E5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PiggyBac transposable element-derived protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060038.1">
        <property type="nucleotide sequence ID" value="XM_038204110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8E5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204110.1">
        <property type="protein sequence ID" value="XP_038060038.1"/>
        <property type="gene ID" value="LOC119731092"/>
    </dbReference>
    <dbReference type="GeneID" id="119731092"/>
    <dbReference type="OMA" id="FWLEIST"/>
    <dbReference type="OrthoDB" id="6141774at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19304" checksum="F81D9B50955A1C42" modified="2023-02-22" version="1">MGGVDRADQLPSYYMYTCSRKSQKWWKKLMYFLVDVCRVNAWLSHVHHHPATHIASSSASEDDLERPEMQSGTISHSKFIMEVPKGLIDGYSKGSAPRQSRTQPLSSHSAPLHQRQRMPGKYAKQCRWCLRTKKKSTKRVPKTRHGCLSCNVNLCEGRCFQMFHGAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8F6</accession>
    <name>A0A914A8F6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059694.1">
        <property type="nucleotide sequence ID" value="XM_038203766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8F6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203766.1">
        <property type="protein sequence ID" value="XP_038059694.1"/>
        <property type="gene ID" value="LOC119730744"/>
    </dbReference>
    <dbReference type="GeneID" id="119730744"/>
    <dbReference type="CTD" id="55005"/>
    <dbReference type="OMA" id="EMFFFRE"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="273"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="59457" checksum="67EBA086F97C35F0" modified="2023-02-22" version="1">MVPKLHLLPAETLLLHNLKIDWCQPAMFRHQLYLAGCMFSGSNLCGLLHKARNVAPGFLQKMAQKRTGTIHTSCSSLQLCKLHKCQHEKASSVYQWKLEGSRTIHRKMTDLWTPNSRGLSTSCTPRTPARCLCSVMTKHGFPYHERTPAWRMFRVKHTKSGQGEVPLVFVNKAPSVVGKKNQKKQPTEPKSPVVRSRTKKPTRLGLQDKKDTQDSWLCTAFSTAEEYHLEHLSLDLQSQGSFLPVAMPQDAQDVLLMDVASSDAENKTEPSEMFFFREGSVVFWNVPDSTLKKVLRIVNKYESRPYEVALVTWENEHINYSYGSQGTKLTDDAIILDENADTETTMLEKFAFSNAMALSVKLGIWELSVDKFTSSLERIPESLKHGHRLKMSRLEVMRKTGELFSLRHQINLSSDLLISPDFYWDRDDLDELYNKTCHFYSIGRRTRVTNEKLNHCSELVELMRTHLSERHSLKLEWMIILLIAVEVMFEVVHYIRRYYEDSGQGIAEQTTSMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A915</accession>
    <name>A0A914A915_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059924.1">
        <property type="nucleotide sequence ID" value="XM_038203996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059925.1">
        <property type="nucleotide sequence ID" value="XM_038203997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059926.1">
        <property type="nucleotide sequence ID" value="XM_038203998.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059927.1">
        <property type="nucleotide sequence ID" value="XM_038203999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A915"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203996.1">
        <property type="protein sequence ID" value="XP_038059924.1"/>
        <property type="gene ID" value="LOC119730927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203997.1">
        <property type="protein sequence ID" value="XP_038059925.1"/>
        <property type="gene ID" value="LOC119730927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203998.1">
        <property type="protein sequence ID" value="XP_038059926.1"/>
        <property type="gene ID" value="LOC119730927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203999.1">
        <property type="protein sequence ID" value="XP_038059927.1"/>
        <property type="gene ID" value="LOC119730927"/>
    </dbReference>
    <dbReference type="GeneID" id="119730927"/>
    <dbReference type="OMA" id="LPQHMMI"/>
    <dbReference type="OrthoDB" id="3156061at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000966">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000185">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001239">
        <property type="entry name" value="Zinc finger protein 615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001111">
        <property type="entry name" value="Zinc finger protein 92 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001671">
        <property type="entry name" value="Zinc finger protein 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF161">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="43714" checksum="5F4C0573F96154CC" modified="2023-02-22" version="1">MHNGDQTLEKTFPCDTCGEAFSQQSHLKVHIRVHNGERPFDCDTCGKAFKFQSGLNRHEMIHLGEKPFVCETCGLSFCRRISLREHTRVHTGEKPFVCDTCGKAFSLRGNLNKHHLVHTGEKPFACETCGRAFSQRSGLQSHIRIHTGEKPFVCQTCGQAFSHSNRLSTHKRVHTGEKPFVCAICGEGFSHQKGLNIHDRIHTGKKPCVCDTCGKAFKFHSQLNIHYRIHTGEKPFVCETCGRAFARRYNLVEHKRVHTGEKPFVCDTCGKAFATHTCIRRHDRVHTGETPFVCETCGKAFSQRDDLQTHIRVHTGEKPFVCKTCGRAYSHRSSLKKHTKVHTGGLSRQELIHTVDEKPFVCEICGEAIACQSELYRHIEGHMGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA51</accession>
    <name>A0A914AA51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038060732.1">
        <property type="nucleotide sequence ID" value="XM_038204804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204804.1">
        <property type="protein sequence ID" value="XP_038060732.1"/>
        <property type="gene ID" value="LOC119731605"/>
    </dbReference>
    <dbReference type="GeneID" id="119731605"/>
    <dbReference type="OMA" id="WIVRNCY"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="203"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="418" mass="48405" checksum="BEF39B84F5BC0F0F" modified="2023-02-22" version="1">YDSFETLSWVYLLFVLQKWVLVVIAVCVVLQILAFTATKSTFLHPFGISDDLTDTYKENPYNVLIFGAKEHLSQRLDFLEETGGVWKHEFSCDEDTKMVVSVGKNKTDFSDQDAVVFNMDEAAVVRDITMLVSMPASHNQAWIYYGMEPAARLRWLFKADSGSLPLHGVWSFRRDAEVQMRYGYFVAGESATNDSQPMDRWLRGKTKLVAWIVRNCYTTFWPRYEYVASLQKHIAVDIYGACGPLFCPFEPRSECIKILKQYKFYLALESAECDDYATEKLWETAYTYGLVPVVYGAQREFYAKEAPPNSYIFAGDFNSTKQLADFLLYLDQSPMQYAKYFDWRQTGHIELPKMADHSLSPALFCPLVPFIDKVKSGKIAKRTLFEHPYYISCAVLKGRDATFRPKLRWKLRRWKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAG4</accession>
    <name>A0A914AAG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060850.1">
        <property type="nucleotide sequence ID" value="XM_038204922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204922.1">
        <property type="protein sequence ID" value="XP_038060850.1"/>
        <property type="gene ID" value="LOC119731702"/>
    </dbReference>
    <dbReference type="GeneID" id="119731702"/>
    <dbReference type="OrthoDB" id="10046852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="84"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="238" mass="26547" checksum="2C2718F21BDB1A48" modified="2023-02-22" version="1">MVSCHQVCFFGSEYNPQSGIPVNWFLPYKDPCNCTAIRLGGMSISASSSHQGAPYYLNDFFLSEDCDEIHAHFNCTPAEKDPECASHALGMEDGTIPDDRIKASSEIYTDCCPAVYARLNSNKRWIPSNTDANPWIEVDLIGSTVVIGVITQGWMPPSSDPQYVAQYKVSYQKQPSSDYDHVADRNGNIKVFIGNTDDHTPVTNLFDESVVVTVVRIEPTEWQNLCSLRLELLGCRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB93</accession>
    <name>A0A914AB93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061018.1">
        <property type="nucleotide sequence ID" value="XM_038205090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AB93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205090.1">
        <property type="protein sequence ID" value="XP_038061018.1"/>
        <property type="gene ID" value="LOC119731818"/>
    </dbReference>
    <dbReference type="GeneID" id="119731818"/>
    <dbReference type="OMA" id="MDCPFFL"/>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="745" mass="83315" checksum="B483CADCB25C52D7" modified="2023-02-22" version="1">MEKQVESAAMVLSKISRSHLECSICHEKYQAPKLLDCLHSFCERCLVAYKKSTAKSSDMMPCPVCRKETKLSSDGIPGLRTNFHLMGMVDDFTLQEKLTQQKSFKLLCELCQDQPKAEFRCMDCPFFLCVNCREVHRRIAATTHHDVLALDALRSGTVSLRSKVKDEPPCEKHRGEKMRFYCETCKELICRDCTVVEHRESEHKFTTVHDAASRFRKATQERIVKVKESLTAHKETQVEMTKMADQLNKTDSLSHQQVIDQANEEGSKIAERESNIRKDLSRRKKFRLKTLQINGISFTKSRPQESKSTESSSTAEENMQKYSQSLEDKFAKVDKALVTLGQNVETLIKTDQDMHSVIDSLNEEALKDANDDRSKAAASKDKLSSQIQSTYDLRQQVIKELAKMTDAQIQRLSHALDTASDVVKSASDVDFLNLHSVIDSDLQNLLEESPANLHPGYPKIEFKSSDDTGLGELVVGATWKWEKDMSSAGNYLVRNFCAFTSGSKVLVRTDGGLCVWDTTNSSKTGQGVSGERIAMFPDNAFVSMDSSYVRLYDLNSSSPKSQFNLPSTIKQDGSDNDTTLGQPISIAHYKDKLLVIGYTNWQGVLVHDSSDGKVIHQLPISIKPDFLTSTSHGRMLVAARSPAVIEVIDSRGDAVVTIHPTVEGVPEGKQVGCVGMCRDKRDTIYVALLIDGESKVHVHQYSPYANFLGCSILDISPPVCGIAVTEEDRLVLAENYKMKVYETKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABE1</accession>
    <name>A0A914ABE1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060771.1">
        <property type="nucleotide sequence ID" value="XM_038204843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABE1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204843.1">
        <property type="protein sequence ID" value="XP_038060771.1"/>
        <property type="gene ID" value="LOC119731643"/>
    </dbReference>
    <dbReference type="GeneID" id="119731643"/>
    <dbReference type="OMA" id="MVEYENS"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="151"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="302" mass="32847" checksum="247F6C9A14E12CB2" modified="2023-02-22" version="1">MSPSMKCTLLVTVIFSTLSIEAVFVLSYQVCFIGSVYDARTGNQRRWFLPNEDPCECTAIRLGGMTVSDPSCQQVAPYYLKGFILSEDPEEIRDFLDCPVSTSTAVSSSTAVSSSTAVSPSTAGSSSTTVSSSTAFSTSTAVSSSTAAQGCLEPLGLRDGTIPDERITASTTQGSFAASHGRLGYDGFWRPTNHDSGAWIEVDLVRDTQVYGVITQGSNESYFRVTQYRVAYQQPSAPYSQLYAKNDKGSIEFIGNEEDAEAEITNFFEESVLATRVRIEPTKWSNKIALRFELLGCPLYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADL8</accession>
    <name>A0A914ADL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform</fullName>
            <ecNumber evidence="4">2.7.1.137</ecNumber>
            <ecNumber evidence="3">2.7.1.153</ecNumber>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Phosphoinositide-3-kinase catalytic alpha polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine protein kinase PIK3CA</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:55633"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77137"/>
            <dbReference type="ChEBI" id="CHEBI:83243"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:43397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3. Interacts with RASD2. Interacts with APPL1. Interacts with HRAS and KRAS. Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2. Interacts with FAM83B; activates the PI3K/AKT signaling cascade.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="4"/>
    <dbReference type="EC" id="2.7.1.153" evidence="3"/>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038061444.1">
        <property type="nucleotide sequence ID" value="XM_038205516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205516.1">
        <property type="protein sequence ID" value="XP_038061444.1"/>
        <property type="gene ID" value="LOC119732122"/>
    </dbReference>
    <dbReference type="GeneID" id="119732122"/>
    <dbReference type="CTD" id="5290"/>
    <dbReference type="OMA" id="RWSEWLN"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005943">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class IA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005944">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class IB"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05165">
        <property type="entry name" value="PI3Kc_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000006">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000041">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000007">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF111">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE AGE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="25">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="27">
        <location>
            <begin position="185"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="28">
        <location>
            <begin position="325"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="26">
        <location>
            <begin position="493"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="24">
        <location>
            <begin position="740"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1040" mass="120176" checksum="80D197AA4DAE51C0" modified="2023-02-22" version="1">MPPSSGELWGSHFMPAKINIECLLPTGIIVPLECVREATLENVKALLWKEAKKLPLANKLSEASSYIFVTITQDAEREEFYDEGRRLCDLRLFQPWLKVVEPAGNREEKMLNYEIGTAIGMPVTEFDSMKDPEVVDFRRNILTLCKEVVEEREMQGKTEHAMYVYPPNMYVLPELPKHIMQKLDRGRVTICIWVISSSGDSMSYTCKIAHDCKPEDIIAETIRKRTESMALSPNQQQRCVEEYKGTYVLKVCGCDEYIMDNYPISQFKYIRQCILRKKTPKLILMARDSLLNSLPEVTFPLPSYMRRAPPTLPRDNLQAKCLWDVSDYFKVKINCAMYVNVKELDKIYVRSGIYHGSESLCPQVMTEHVPCSNPRWNEWLTYELRIPDIPRSARLCVSICSTSKRKGKKESVCIAWGNVNLFDYTNRLQAGSLRLYLWPLPQGHDELLNPFGQTGSNPNKDAPCLELECERYKYSLVFPQFQEISDHAANVPSKPSKIPSVEEARLLDEIIRRDTLHEMSEQDKELVWDCRLYCQARPNSLPKLLNAVKWNSRDDVSQLYILLKDWDLVDNETALGLLDCSYADLGVRTFAVESLEQNLTDEELLQYILQLVQVLKYESYLDNPLARFLMRRSLYNQRIGHFFFWHLRSEMHKPKVSQRFGLMLEAYCRALGPYLKLIVKQVEAIDKLTNLTISLSVRKDDTSKDRLKYLSDQMQQADFIDALQHFPLPLNPTFTLGKLKVEDCRIMSSAKRPLWLVWENHELMADAMFADMKIIFKKGDDLRQDMLTLQIFEIMDNIWQMNGLDLNMQPYKCLASGNATGLIEVVQNSLTIYDIQHKAGIMGTLQLKSSVLHQWIKEKNKGDQYDDAIDMFTKSCAGYCVATFILGIGDRHNDNIMLNENGQIFHIDFGHFLGHIKKKYGIKRERVPFVLTEDFLRVITKGNDINKSPEFKKFQELCCSAYLILRRSANLFISLFSMMLATGIPELQSIDDISYLRKTMAVEKEEAEAVEYFMKQLNEAHGGGWTTKMDWLCHALKHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEG2</accession>
    <name>A0A914AEG2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062320.1">
        <property type="nucleotide sequence ID" value="XM_038206392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206392.1">
        <property type="protein sequence ID" value="XP_038062320.1"/>
        <property type="gene ID" value="LOC119732753"/>
    </dbReference>
    <dbReference type="GeneID" id="119732753"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000051">
        <property type="entry name" value="zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002075">
        <property type="entry name" value="zinc finger protein 646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001134">
        <property type="entry name" value="Zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="779" mass="87619" checksum="ED6C0A605DD82F81" modified="2023-02-22" version="1">MEQTKQKTFVCETCGKAFSCRAYLNRHDRMHTGEKPFVCATCGKAFTQRSHRNLHERRWHTNEKPFVCETCGKAFTLRSSLNMHEVIHTGEKPFLCTTCGKTFSQLRLLKVHGRIHTGEKPFVCVTCGKAFTDPSGLRQHKIMHTGEKPFVCETCGKAFARRGHLNGHYKSVHTCRKPFHSETCDETLIIQQCDPNRQGRINTDVKPFVCETCGEAFTQQNDLNLHACVHTDVKPFVCETCCEAFTQQNDLNLHASVHTEAKQFVCETFGEAFTQQNDLNLHASVHTDAKPFVCETFGEAFTQQNDLNLHASVHTDAKPFVCETCGEAFTQQNDLKLHVSVHTDVKPFVCETFGEAFTQQNDLNLHAGVHTDVTSFVCETCGEAFTQQNDLNLHASGHIDVTPFVCETCGEAFTQQNDLNVHAWVHTDVKPFVCETCGNIFEELLALRQHEKIHTGEKSFCDSANCGKTSTTQSSRNKQNKVDTGEKPFVCEICGKAFSCRAYLNRHDRMHTGEKPFVCATCGKAFTQRSHRNLHERRLHTNEKPFVCDTCGKAFTLRSSLNTHEMIHTGEKPFLCTTCGKTFSQLRLLKVHGRIHTGEKLFVCVTCGKAFTDPSGLRQHKRMHTGEKPFVCETCGKAFARRGHLNGHKSMHTCRKPFHSETCDETLIIQQSDPNRQGRINTDVKPFVCATCGKTFAQLRLLKVHGRIHTGEKPFVCVTCGKAFTDPSGLRQHKRLHTGEKPFVCETCGKAFARRGHLNGHKGVKTCKNHAILKPVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEM5</accession>
    <name>A0A914AEM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062222.1">
        <property type="nucleotide sequence ID" value="XM_038206294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206294.1">
        <property type="protein sequence ID" value="XP_038062222.1"/>
        <property type="gene ID" value="LOC119732662"/>
    </dbReference>
    <dbReference type="GeneID" id="119732662"/>
    <dbReference type="CTD" id="136332"/>
    <dbReference type="OMA" id="CNQISEM"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000828">
        <property type="entry name" value="leucine-rich repeat and guanylate kinase domain-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF18">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="376"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="775" mass="85271" checksum="343DD64F5AF527E6" modified="2023-02-22" version="1">MEDSHVDCFRPDSGPVNDELERASPYFIESTVSPNGNLPNGDNRFEIHDHGDESGASEDEELSPDGVLDERTVAKGLSNLGRTAGGNDLVFLHLTLPGYNLQDITTLKDYTHLQKLEIPYNKISDLSVLSFMPYLVELDASNNEICNLNSFKSPLNLKEVDLSFNNIEDLNDFTEHRTITKLVIDNNKISSLDGLQACKSLSYLSVAHNRIEKIENLQALPLKYLNLRGNRLKEIENIESLGQLQQLDVSGNFIGSLKGLETNRLLETIDLENNHVESIDDVKHVQEISLLRNLNLLRNPIQGVADYRLSLLYCLPQLTELDRHKVEAEEKVSASNLFNAPMDVEAAEDHRRCMVYASLRSARIYDSTLPSMETPYPMLVLVGPPGSGKHELAHKLVAEFPTYFGYGISHTTRAPYTGEMDKKDFHFVSAGSFDSKIKQGVFLLTYQSEGHQYGVSQEAIEDVAKEGLACILTMEVEGVLSLKLSYYEPRYILLLPLDQAAHETRLRAVGNLSQENIEQAVREMGRYRGIHQDKPGFFDMTVDSSDLTAAFDRCRELVSGYLGLGETEPQHLTISNWVPSSDSPSPTQARSDSQTPMGDRSVTPLRSTSGMKTWSDRVKSADTGSQISRKLMSPGMKAMLQPKRSSVEQASYERRKSAARAAAAGIEPKPLDQLIARPPGTAPETLQGKGLDGSTTRPKTVPAGYYEAPSPDSSAASRSGSELSGLSEARGMSGNVSPDSTASQQLPVDMTLPGYGTDDGMGGRSDGSLIMSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFA1</accession>
    <name>A0A914AFA1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062650.1">
        <property type="nucleotide sequence ID" value="XM_038206722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206722.1">
        <property type="protein sequence ID" value="XP_038062650.1"/>
        <property type="gene ID" value="LOC119733147"/>
    </dbReference>
    <dbReference type="GeneID" id="119733147"/>
    <dbReference type="OMA" id="CERGNSA"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71470" checksum="327C9A6D78BE6DE1" modified="2023-02-22" version="1">MATALKNIGPHLECIICADKYKQPKVLDCMHSFCQKCLEKYYTSRYAGQPKIPCPVCRRETVLPETRIQGLKTNFHLMGIVEEVSLQEKVVSSENTKVTCEICDEGNEAMHRCLDCAQNICSNCRKTHLRCTATSNHTVATLEDIRQGKVTVKKTPEEDESRCHKHKGEVKRFYCETCEELICRDCTVVDHCKPEHHYIDSGEASRKYKQSMKDTFPDFTTGIKRLEQALTTSSQVKQKFTQNVTKTVKAVQDKADKMRAEITTQETKMIKEIKQLQQDRNRTYDEHQSTLTMMLESKKHSLGTSQDIINTASDSDFLSLYPIISKDLKSLKSQNTPQIDPKLSYLSFTPGHGYINLGKLDGVEAVKWEMCRKFGKRGSGRGEFNLARGITATQPGEIAVADMMNNRVVICSNEGQHKGTILLKSNPVAVAAIHNHEQCLLVLDLGNKYVKVFNMKDNTLVMQFPTMLKHQVDKTKMNLQSLAVTKNSILVGDTNNMVWTEHRPTDGEILRTIPVQTPPHFLAVDDDTDRVVVSGGNTKKVVVGDTKGRTIWTINPTINGEPVGNCKGVCCDSSGIYLAIAMHQGVSDTGHIHHYDQDGRFLNCLAQGLYDPQGIAFTSDGQLAVADWFSIKMFHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFM7</accession>
    <name>A0A914AFM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062174.1">
        <property type="nucleotide sequence ID" value="XM_038206246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206246.1">
        <property type="protein sequence ID" value="XP_038062174.1"/>
        <property type="gene ID" value="LOC119732628"/>
    </dbReference>
    <dbReference type="GeneID" id="119732628"/>
    <dbReference type="OMA" id="HVTFWQA"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000433">
        <property type="entry name" value="zinc finger protein 384 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="517" mass="57218" checksum="74ECDC8C1BBE86A8" modified="2023-02-22" version="1">MSLQRPPFSPPPSHVTFWQAEVEQLQRNHHFSTQVPGMDPRPPLTPGKPPTTGYECNKCCARFASIASHVAHEIAGCVTMSPSTSQQQAAALYTRNTVQPTPVVNQAASRPAPVGSNGLPNHSGNTTSSSPRGKGGHKAEKVTSPRSFLEAEQGGQEYHCKICPQVYYSKSDVLLHARSHTEGKPYKCEDCGKGFATTSYLSQHSRVHTNHKPYNCTYCDKSFKQLSHLQQHTRIHTGMKPYKCFDAGCDKAFSQLSNLQQHWRRHNKDKPYKCRDCYRAYDELEKLQNHVLSHENTRREKRFSCGVCGKTYSLEVYLQKHMDKHPQHPQLANNGLANLPIVDSNKQSNSSAGSNLTHHKKHKKSKKKSNPDPAPTMNMHQPVMNMNDYSAAETTSHLVPMLMHLQAPDSVLQPLTLPPRCGVQSQTTDAKPGTQPHGFPAHTATSPAVGSHPLNLHIPMPTSLGYMNRGPAVFSTESPTFTSSSPAFQSPSHIVDSRMPYFPLPVSAPNVSHVIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFT6</accession>
    <name>A0A914AFT6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062593.1">
        <property type="nucleotide sequence ID" value="XM_038206665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206665.1">
        <property type="protein sequence ID" value="XP_038062593.1"/>
        <property type="gene ID" value="LOC119733086"/>
    </dbReference>
    <dbReference type="GeneID" id="119733086"/>
    <dbReference type="OMA" id="SERAMCK"/>
    <dbReference type="OrthoDB" id="10032694at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="20575" checksum="D724FCDE36DFC265" modified="2023-02-22" version="1">MSGANIPSERAMCKTQKMLLKDNLAGETIKLFFNTNAADGINGMKLKETPFVYVKDIGAMILDYLDRHDQQGTLTWHNGVIPANEIWIKVGGDKGGNSFKMDFQIVNVAHPNSIKNTVVFSCVEATDSMANIRRALLPIFEQLSVLSTLKWRGRSLRVFLFGDYELLNKVYGICGCNARTAFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFZ2</accession>
    <name>A0A914AFZ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062431.1">
        <property type="nucleotide sequence ID" value="XM_038206503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFZ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206503.1">
        <property type="protein sequence ID" value="XP_038062431.1"/>
        <property type="gene ID" value="LOC119732924"/>
    </dbReference>
    <dbReference type="GeneID" id="119732924"/>
    <dbReference type="OMA" id="EPWPKEF"/>
    <dbReference type="OrthoDB" id="6512834at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38945" checksum="917D6176CD805F71" modified="2023-02-22" version="1">MAVFSFQKMRLKFHVTYKSSKRIIEHESANERGNVDEITKSICEQFKIPRDGEQVQLQYFDKDFGDWVDVAPMSSLENMTRLQVLMTAAHSDNEHDEAVPTPVSECSGESPKASEGPTLSTTTSPKTFRVWPVQFNFPVYALRAGVLQKLRSGEKLSRGERTQITDAVYQEVTKYTYYPKEWQYTEVVTAFMEKFPKVKSNENLSMSLWRQRIQYRFQNDRRRRDCVPGKRRLADPTSTAAGPPPTKNDKLMWGLKNYISQRPEGEDSTSIERHQAAMKVELAKRNPDRSRVDRLMALTFADRREFIIKGNPLMADIKARFPALLAGGSEVFIWLLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHE6</accession>
    <name>A0A914AHE6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063415.1">
        <property type="nucleotide sequence ID" value="XM_038207487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207487.1">
        <property type="protein sequence ID" value="XP_038063415.1"/>
        <property type="gene ID" value="LOC119734131"/>
    </dbReference>
    <dbReference type="GeneID" id="119734131"/>
    <dbReference type="OMA" id="DDNICIA"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="40283" checksum="094953A9A1F4BADB" modified="2023-02-22" version="1">MFCSDCRGLYKKTALYRHKKMCPRHKPNKKRTRHLRAGAALMPVSENVTRHLNGVLDGMEHDQISLIARNDSLILKLCEHYAAAAGHTNNSNHYVSQKMREAARLLNTARTLDDNICIAKDLVNPRNFDTVVEATLKCSNFDDSTFEFSTPSLARKHRHILNRMAEIICAVALKTGLSDNSGAGFKRLMQLEWPTRVSGHALRQAANSNWNEPKRLPLTKDIMKLHQHMCKEEREIKGQTKQYGISWETFSQLAKLTLAQLIVYNRRRPGETQFLKVETYRKKKSRGMDANSDVVDSLSLSERLSIERLSVVYIRGKRDRGVPLLLTPSVRESVDVLVGSREEVGKTRKSICVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHP2</accession>
    <name>A0A914AHP2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063051.1">
        <property type="nucleotide sequence ID" value="XM_038207123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207123.1">
        <property type="protein sequence ID" value="XP_038063051.1"/>
        <property type="gene ID" value="LOC119733751"/>
    </dbReference>
    <dbReference type="GeneID" id="119733751"/>
    <dbReference type="OMA" id="FCTENEG"/>
    <dbReference type="OrthoDB" id="10003658at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="279" mass="31755" checksum="9BEBE6961420A1D8" modified="2023-02-22" version="1">MSTPQGHQGRAVLKRKTTSSGVVGGTSGVDKIYNKVLTLFEERGLYFCTENEGTYVVQTLTRALWCITNPHSTLARKKSLPCLWHGFENFNDLKKKKHRKQCLCSSDLTRHGDEFYALQGRPSISGSKWKDVRCAVRELGECLIEYAEYLRIQAEKQNKRQKMNHCVTQLSDAASVAFRVKVSHVDDQYRQIDEVVAAQSFGESVLFDEHLHLLKPFTNRMQQMRFFEDLHLSVDVDMLKYCPGGSHVAVYVICKVPVDRPYSQAPTDAAKLLAANQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIG7</accession>
    <name>A0A914AIG7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063336.1">
        <property type="nucleotide sequence ID" value="XM_038207408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063351.1">
        <property type="nucleotide sequence ID" value="XM_038207423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207408.1">
        <property type="protein sequence ID" value="XP_038063336.1"/>
        <property type="gene ID" value="LOC119734030"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207423.1">
        <property type="protein sequence ID" value="XP_038063351.1"/>
        <property type="gene ID" value="LOC119734051"/>
    </dbReference>
    <dbReference type="GeneID" id="119734030"/>
    <dbReference type="GeneID" id="119734051"/>
    <dbReference type="OMA" id="MFIMAPL"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="30731" checksum="2A17371798B69DA8" modified="2023-02-22" version="1">MSGVVSNSLEGPDGGRPGWVAVLALWTENLMETGITKGLGIMLPILQIQLTSQMWIIGWIASLTIATSGFVAPFGGLVSRRFGADYVMMTCGVMMSAAAIAGSFVENPLQLALLYTLLAGTAIGISSVVAKEVVGRCFTKNYATANGIARTGYSVGLIVFAPLVQLFLNTYGWRGTMLIVGAITMHFVASGAVMVATRQPELDQSNAYQTLPQTERTNSPSAHESTLRSHRSSLRKFVSKNFEAGLLLNARFWLVAVISCCTIYAYLMWIVYFVSQAQSNGFTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIU6</accession>
    <name>A0A914AIU6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Suppressor APC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063652.1">
        <property type="nucleotide sequence ID" value="XM_038207724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIU6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207724.1">
        <property type="protein sequence ID" value="XP_038063652.1"/>
        <property type="gene ID" value="LOC119734297"/>
    </dbReference>
    <dbReference type="GeneID" id="119734297"/>
    <dbReference type="OMA" id="TMGLERN"/>
    <dbReference type="OrthoDB" id="10035013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11414">
        <property type="entry name" value="Suppressor_APC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="3">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="54882" checksum="64144677244C4B83" modified="2023-02-22" version="1">MASSVAATQTSKPPEVTVEGFPKAFVASMKVLFDILDEDVDGLVHIAEIEKRWAAEGGTTGLPFGVLNGLRKAAPKNGKLSFERFCGGLKMSLNFERGVGRVGREDKQPNTATVRPNNVVRPMAVRTRSAPQLPRAPNARPRSLSNNTDPVTDWEYAVQKARSSEDKVHNHSGKYRVREDLKLKRRSAPGDINANDPSHPRIQKESNHRASRRSEGDYVRYQPAQAPRPGPQGPGRVGPKPERAVNGPVYDHPRSPVETKPVNGHVSSERHSPNHSPKQKSEAKERSRRADPRRHTVSNGIDYNLLKRMKQLEQERDVLLQGMEVAERSRDWYQRQLAYVRQRQPGYSGNSQFTHGEDSPVSGQQDRLAYRMSRILEINRQLTHLMENPEKDFPDHMNLALASFQPSQAPPKQRMSSTSSSSSMNSNLIAQLREQNKLLTKEVSEKSELITQLEKDKAALIRQLFEARGKTHQNNKKKEMPNNTTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ54</accession>
    <name>A0A914AJ54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038063434.1">
        <property type="nucleotide sequence ID" value="XM_038207506.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207506.1">
        <property type="protein sequence ID" value="XP_038063434.1"/>
        <property type="gene ID" value="LOC119734161"/>
    </dbReference>
    <dbReference type="GeneID" id="119734161"/>
    <dbReference type="OMA" id="DRSHISA"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="108"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="544"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="666" mass="75027" checksum="D44EE99B351E1270" modified="2023-02-22" version="1">MTAVDRSLFRAARFVRFVFHSLPPFRTMLKLGIFGGFAALLRGYFELEWRTVGVAVVTVYLATGGWRFAKILVRTLPRDLKGLFALIRLRVTLYRRSLNHELVHNVLETRTKLHPDKVAFRCEDEVWTFRDANNYANAVANYFFEKGLRKGDTVAIFMETRPEFPCFWLGLSKIGAVGALINFNLRQESLVHCIQVAQPKAVIYGVELTDAIKDVKSEFGRNIPFYSTXGYVDAGFPALNLDPELQATSKLPAPVVLGRKFTDILFYIYTSGTTGLPKAAKVTQIRFMYMAYGIRYAFHFRFDDIIYNTMPLYHSAGGXVGMGQVVLNGSTMAMRRKFSASRFWDDCIKYQATIIQYIGEICRYVLAQPXKPTDTQHKVRSALGNGLRPQIWKEFQERYRIKQICEFYGSTEGNSNIVNISGKPGAVGFISLLVPSALPLSLLKVDEGTGEVIRGPDGLCVPCRPEESGHLIGKIKVGHPLAGFDGYVNKQATDKKIIYDIFRKGDQAFLSGDILVMDQDGYMFFRDRQGDTFRWRGENVSTSEVEGIIQKHVQLNDAVVYGVEIPGLEGRAGMVAIVDTEGTLDLVKLNQSLKSSLPPYARPLFIRIMQEVDTTGTFKLKKVDLRKENFDPTKVGDDKLFYMNGKEFAPLTQSVYDDIIAGKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJZ9</accession>
    <name>A0A914AJZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038063948.1">
        <property type="nucleotide sequence ID" value="XM_038208020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208020.1">
        <property type="protein sequence ID" value="XP_038063948.1"/>
        <property type="gene ID" value="LOC119734489"/>
    </dbReference>
    <dbReference type="GeneID" id="119734489"/>
    <dbReference type="OMA" id="KITHKVA"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000008">
        <property type="entry name" value="dynamin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="17">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="522"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="16">
        <location>
            <begin position="659"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="756"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="848" mass="95030" checksum="C476A90FB48857AB" modified="2023-02-22" version="1">MGNHGMEDLIPIVNKLQDAFASIGLSSSLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLNQSKAEYGEFLHCRGKKFTDFDEIRKEIEAETDRITGSNKGISPIPINLRVFSPHVLNLTLIDLPGMTKVPVGDQPADIEMQIRNMVMEFVMKENCLVLAVSPANSDLANSDALKVAKEVDPSGTRTIGVITKLDLMDDGTDARNILENKHLPLRRGYIGVVNRSQRDIEGKKDIKVALAAERKFFLSHPGYRHMADKMGTPFLQKVLNQQLTNHIKDTLPALRNRLQQQLLSLEKDVADFKDVNYDDPTRKTKHMLQMVQQFGADFEKRIEGSGDEINTMELSGGAKINRIFHERFPFEVVKMEYDEKELRREISYAIKNIRGVKVGLFTPDMAFEAITKRQVSRLKEPSLKCVDMVTNELNNVVRQCGEKMQRYPRLREETEGIVTRHIANKEQKTKQQVMLLIDIQLAYMNTNHEDFIGFANAAAATRRSTTNNPNSTKTRSVTNQVIRKGYMNMHNVSFIKGGSKDYWFILTAESISWFKDNEEKDKKYMLPLDGLRLRDVESGFMSRRHSFALFLQDQRNVYKDYKQLELSCDTSEEVDSWKASFLRAGVYPERTKDENESGEAPSGDAMGSMDPQLERQVETIRNLVDSYMKIVSKQIRDLVPKACMHLTINDTKDFILGELLAHLYSTGDQDSLMEESQEEAQRREEMLKMYHTTKEALKIIGDINLSTKAVPLPPPVDNDDLIKPFANGPTPAPSSSAPRRPGTHGAPSRLAPGGAPAAPGPRASPIPMIPSRPDMPARQAPSVPKRPAGSSAPPIPGRPAVPARPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK07</accession>
    <name>A0A914AK07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stereocilin LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mesothelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063896.1">
        <property type="nucleotide sequence ID" value="XM_038207968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207968.1">
        <property type="protein sequence ID" value="XP_038063896.1"/>
        <property type="gene ID" value="LOC119734462"/>
    </dbReference>
    <dbReference type="GeneID" id="119734462"/>
    <dbReference type="OMA" id="TCEMIDN"/>
    <dbReference type="OrthoDB" id="8195838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010335">
        <property type="entry name" value="Mesothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048992">
        <property type="entry name" value="Stereocilin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF17">
        <property type="entry name" value="OTOANCORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06060">
        <property type="entry name" value="Mesothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21058">
        <property type="entry name" value="Stereocilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037403261" description="Stereocilin LRR domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Stereocilin LRR" evidence="8">
        <location>
            <begin position="225"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133274" checksum="9911F88337CA4D04" modified="2023-02-22" version="1">MLQLFQAGLLLVFLFGRQFLETRASDSSNQRARPSPTPDHQWHEAFDMTEHDADILNDRSLHDVADVYDNFFVPGASGWRDLNMTAIMREAEKQRQDAMQNGHSSRPVFIKQPVIPNTVLKRLSPDIIQNMTAAEVLQLADATEMSYESMTHLLSNLRPQEFDKLLSLSRNYTDFETESPDPTTAKAVIDSCHRHWGPVSQWTVSQVARLGPMLTSLNIEQIKQLNDEVLPEVIKAFARLGFQGQATRTLVLKAKRSWGAIGTWTLDKFTTLGPLQTYLTPQDLKQIQPGQLNFTSLLSLLGSLDLDRGQARAVINIAAGLPEWRWTLEQVQSLGKMTRFLDSRELRAAPASAFASPELLKELLPSDGRGHQQQTKEIARVLKESRGTVNDWTAEDFRSMGRAASGLEVNDLEQLDPSVVQGAIADIADAEYSPRQRNVLIEKYREARGSRDTSMSADEVRQMKGLAVGLSTSDLAHMDPQDVRESMDVFASNANKMKKTQKREIIKQLKEAPGGIQDAIQDMGDMVKELPLRDLDSLCTANFTAAADENSTGVAAAGRMNWTEGQSMKLFRCFKDEVLGSSEGEGGSSADLLTPATIRYMGSMAKGMSCDDVEGFVADDILPTVGAMMEQEGWSPRLLDCTHQKIKASLSAAHDDYTADFTEIEIAALRGQLLKELSVEELNSIPSSHCEMLYSEIGNEDLIGLKRDKRKALTSNALQCLGVDGQANTIEQDTMDIIGNLACDLEADMLRRLSSDVFTGNLYSMQKCCLNIDQMVVIGERLVQEMGSPNQWMSDTISDIGPLLVSLSELEIQNLEEEQFSLVAEDVMVRFAEYKDKWSRYCDVDLRPQDISSREEGFVTMAIKAKDALVAVAQADVSGRKRRDSTYSPTCNEIESLSDGNIAWTVDELGAMTVNTFDSCGYALGEVTGFSDAQLAALLDKAKEAWGQAADMTPDQISQLGHIASKFTAAEIGQLNLTETDTVYAIAQYNIYTSDQLSAGVGRFSELSGLSVTSLDSLDLTALANFLCGLTAVEMEDIASIAYQEAANAIGELRSCDAGQWATLKTKAVDGYGAINTWMPEVFAEVGSVVAGFTTQELSSLSDASIAGIKPHAVSLIPPQTLAAGWSSAQLSKLDQLQAEAVTEEQLAALSQEQRSALLEAEYGDDISLAEIEETTEVVVVEDDGDKDGNGAGNQSAGLVPTIIIMCNLMYRAISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKU7</accession>
    <name>A0A914AKU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064054.1">
        <property type="nucleotide sequence ID" value="XM_038208126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208126.1">
        <property type="protein sequence ID" value="XP_038064054.1"/>
        <property type="gene ID" value="LOC119734591"/>
    </dbReference>
    <dbReference type="GeneID" id="119734591"/>
    <dbReference type="OMA" id="AFTHTSM"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="101"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="38270" checksum="86C06C4DB4B87FAB" modified="2023-02-22" version="1">MEKVTTAAATTEILDGPGLDTMYAVITEIVTVISPVLTDENRMVSSDAPISSEDSTISITTDSSVETGNTIQLPIFPPSPLYLFLLKAFFIGLVLVITIIGNTLVLVSFATTRKLQTYTNYYLVGLAVADLVSGGVTPALLNVTFMIGYWPFGPVICRVFIYLNTVFVHATFLLTFIICVDRYRAMSRPLKHLKEKTRNHALKMILPGFLVPSLLWAVVILILPECGVFTPLPPYACHIPYASNKIVLLISSLFISWVPIIGTSILYACIYFGIIRKRPARRSTSLKERNSASVVESDPGSVPDLPKERELVDGDGDCKAREKGENTDEDTCTCATIIIECVWFLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL66</accession>
    <name>A0A914AL66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064482.1">
        <property type="nucleotide sequence ID" value="XM_038208554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208554.1">
        <property type="protein sequence ID" value="XP_038064482.1"/>
        <property type="gene ID" value="LOC119734918"/>
    </dbReference>
    <dbReference type="GeneID" id="119734918"/>
    <dbReference type="OMA" id="ATILYCE"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="457" mass="50698" checksum="E23BA12641E402F3" modified="2023-02-22" version="1">MDKTDSEYTDRMVDSTGNGQIEDENETDAFLPTEPAVPAGGQQCNGKLRNLVAFWILGSSSCYMYVVMLSAAYDILGENYETQDLEHILGMLSRNTTVNENDTSTGRLDCQSLSTGAVLIADILPEMIVTLSAPWYLHFVSYDIKVSCTVATAVLSCLIVALVPFRALTILGVLFASASAGFGEFTGVSLLSFYDKSVVSAWSSGTGAAGLVSALVYAGLTEIGMTPRHAVLVQVIVPFCIAVSYWGVLVRAPTSNRFKMDDEGDEDPDRLVEYDPFQGKCKDSEERHLTFQERVHYLKYLLKYIIPLWLVYFGSYFINHGLLELIFVRGIWLTHESQYRWFQVLYQAGVFISRSSINLISFQRLWIFPILQWAVLVVILCVICFAWTPSIFIIFAIVFVEGLIGGASYVNTFYQISQNEAPKYKEFAMGATTSAEASSVVLAGVIAIPVHDLLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALJ0</accession>
    <name>A0A914ALJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038064870.1">
        <property type="nucleotide sequence ID" value="XM_038208942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208942.1">
        <property type="protein sequence ID" value="XP_038064870.1"/>
        <property type="gene ID" value="LOC119735236"/>
    </dbReference>
    <dbReference type="GeneID" id="119735236"/>
    <dbReference type="OMA" id="LAMCTMV"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="51560" checksum="38BCFB1C33E65C23" modified="2023-02-22" version="1">MENENNKTEPQLVSALKPITGKSCLLILSILVTAYVWLFSGAFTISRDVVKGPDLRVQETTDGCYLEDKLQAPHLPDLHSVFADRISGQVVFVGLKLLRQTWHRVLFRCEFPSGDISVVHAVDDRRSFGHLPQYVVVLTCPIPNEYRLRSSFNITLRRLPGTDAYRNIKACATSNEKHFLAMCTMVKSVDAFIPQWLDYHRYLGVQHVYIYDNDKPAQSTLQTSLQNYIKAGFVTLIPWAHSTSVNKTYLEVQIAHENDCIWRHKHDVDWMIKIDVDEYIQPMDARRPRIPEYLNDSLYDSVAAVRIQNWFFGHPPRIAPRGDSVIERNRWRAEKHTLQNTGHDKNILRPINVHYYKIHSVKLGGDVISADPYTEMRLVHYRTDNQRARHFDLPKFKERDESMVRIRQALVNHRLQGRSSKNNKRRISKKVRKPKISKETIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALN9</accession>
    <name>A0A914ALN9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038064344.1">
        <property type="nucleotide sequence ID" value="XM_038208416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208416.1">
        <property type="protein sequence ID" value="XP_038064344.1"/>
        <property type="gene ID" value="LOC119734837"/>
    </dbReference>
    <dbReference type="GeneID" id="119734837"/>
    <dbReference type="CTD" id="90850"/>
    <dbReference type="OMA" id="WSERHEA"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="273"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="922" mass="102205" checksum="EF1A6177F7382B7A" modified="2023-02-22" version="1">MSKTTDSISSTCVLCCGSIKYYAVGQCNHHICLKCSTRMRVLCEQRYCAVCRAEMPKVIATAKLHPFDGIISHKFPINRKAGIAFATSKIQDEFRRLLWEVCTLCPLRPPEKSCKDLQDHLRREHELFYCELCIKHLKVFSFERKAYSRKDLALHRRKGDGKDTSYRGHPLCEFCDERYFDNDELLRHLRQDHYYCHFCEADGVSNQYYHDYDNLKEHFREQHYLCEEDRCSQEQFTHAFRSSIDLKAHRATAHSNQMSRAQARQMRQIDVEINLPPRPSERGGGGGGPSFGKGRERRYHGNRDDGLSTAIQASMETKKREMAEHRDARRQEREDRDARRTKDKPQPKKKSAANAEPEPDRDGTGEEASSDAVAMETVAKEAGIDETRLQKKGGRASPQVEEAKTEIKEEMRAPSSKNTECLEDENGNRKADTNLPQPVETDTQTGKKKKKKKGKGASDKNENSSENESLLSVPKPLDNKPMETSHQSSDAKAEVHPPKPVTRMSSGAKVEDFPALMKTSTPANVGTTGAPGGFNFYSALQKMDTQPKPQHQPVAVPAQRSFKNREEDFPTLSSIAGILGVEAAPSRTTPTFKTKTTPAWATPKDKSAAMPTEAKPVAGKSKKKGKKSSKENPDIGTSKQNPKAPPGFDIAKKEAKPKESQAVAPQRIPPGLPPGLAPKGPAASQARPVSAAPPVSVAPPVSVAPPVSVAPPKPPAASHPVSPPPGFGVSFHMPNPTLPPGFNVFVPPTDFQERNLQLAKKIKAFLGHQEAKFDRFRSISRKFRDGSMMAAEYYYECQSLLGQNLPLIFNELVSLLPDFVKQQELISAQNDAKFQSKPRQDNSSLAGEKTEPVRAKGRGRGTGAWKGTINAASSCPQCGQVIQRSELEAHLNMHKEFPSLSANAVGKRQPITAAAPTWPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM73</accession>
    <name>A0A914AM73_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064621.1">
        <property type="nucleotide sequence ID" value="XM_038208693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AM73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208693.1">
        <property type="protein sequence ID" value="XP_038064621.1"/>
        <property type="gene ID" value="LOC119735014"/>
    </dbReference>
    <dbReference type="GeneID" id="119735014"/>
    <dbReference type="OMA" id="KCCKIGK"/>
    <dbReference type="OrthoDB" id="10063453at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037502220" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="190" mass="21609" checksum="CECD3511C97AECCF" modified="2023-02-22" version="1">MQTQLALLVLSLLAAVCAEVKLEETIIPEGHEDVIPQGQDGDTPADNPLETAEDAAQVLDELEHDIFDQVEPGTPRPNPYAKTARRCCKLGRQVAENGLFCNLDFLQVQKRPNVVHRRKMKFHGPEVNGKTVYKDLMRKVEKCSLSNAAESMFVKCCEWQEDIIHDLEQCKLLGTLSQRRRCRRRVQARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMJ0</accession>
    <name>A0A914AMJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 72 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CEP72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065250.1">
        <property type="nucleotide sequence ID" value="XM_038209322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209322.1">
        <property type="protein sequence ID" value="XP_038065250.1"/>
        <property type="gene ID" value="LOC119735567"/>
    </dbReference>
    <dbReference type="GeneID" id="119735567"/>
    <dbReference type="OMA" id="HPRAKCT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000489">
        <property type="entry name" value="Centrosomal protein of 72 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055320">
        <property type="entry name" value="CEP72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311:SF5">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 72 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311">
        <property type="entry name" value="HEAT SHOCK REGULATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="633" mass="71368" checksum="7B2BDF5581E4094C" modified="2023-02-22" version="1">MALTISEKWIRERVHLDPENLDDVRSLALPGTYHEKVTHLGTSLQNFCRLKHLDLSRNALQSLDGLQHLTMLEKLNIYYNNISTLKDLYQLGHNTCLQEVDLRLNPVTKNEPDYRLFMVHMLPNLRKLDDRSVRESERKAALMHFNSDQANELTEHLPVKRQTETDRVINPRVEMVANMPRKTTVLDDDDCDVLDLIARSGGDLGRPRDITGSKARASQAATHSHAERLNRESADPRPSSVVDLPSTKYPPSPSQAPAPPAAQIDGPRRPNAWDEDEAAIRNRNLEERMLGLEVSGGTDITGSPTHPAGSHPQSKERVRVQFSDSENGQDSNRDSNARYAEESQAYTAYTSRGHFTPHPDHSDQLREPEGTSSQRDHVNTHPLEGAIDTQPTPTEDSHIDLNLFLDNFLSLVDRYWNGTKSLHRHGKFQSQAHTLLSTLMNRIIASVSQPRPEIPKESSTETSKLRQALRASQDRVGNLKDELDAALADKRNLQANLEAAQRETPSGDRSTDRSGVRSGDSSQQTDRSVRSAGVLEREIEKLRMENESLRLHVKHFNQLQELATMLQESHKSLVTTNDHLLQELDETKQRHLEEVKQLHWSYSELKRTVELAPNMQSAGRHAGLGYATANGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMM8</accession>
    <name>A0A914AMM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064848.1">
        <property type="nucleotide sequence ID" value="XM_038208920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208920.1">
        <property type="protein sequence ID" value="XP_038064848.1"/>
        <property type="gene ID" value="LOC119735214"/>
    </dbReference>
    <dbReference type="GeneID" id="119735214"/>
    <dbReference type="OMA" id="SANIMFH"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="246"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="397"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="77740" checksum="3AE69B3F6C56108C" modified="2023-02-22" version="1">MMIRILGYRFIGAIVRAGLSPNFTENLPCGLPATSEQSKDGAEITFLCEPPQTARYVSVDIDTSMPGVDADQAYLQLAEVAVENVTSGEGADVNDPHPWWLLDLGSKHCLGRINVTLRKDYGGFRFVGAIARVGLSSNFTENLPCGSPATSEQSKKGAEIPFLCEPPQTAKYVSVDIDTSMPGVNPVEAILQLAEVAVEEYTSGECAEYVCINLNPCRNGGTCIPDTAGNFYNCSCPAGFSGEDCQNDVCSNPNPCRNGGTCIPDTIGNFYNCSCPAGFSGGDCQNSAEDPCIPNPCMCENGTSGNNCQNANSNTMPIIIVVVIVVVFLIVGLVIVMVSLFKRSRRKRRGGRPSAVDSGRGQELIENKKSNVYWIDTLQASTSEFSGPAKEFPRDKLHILGQLGSGSFAVVYKAEAEGIIRRGTNTTVAVKMLKESATPNDQSDFKKELQVYSMMDQHLNVLSMLGYCTEKDPMYIILEYVPHGDLQTYLRHIRTGTEPFYMKKEEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHKDLATRNILLGEGLICKVSDFGLAREVAEKSQYEMKSQGKVPVRWMAPESLLSNMYTSKSDVWSFGVLLWELVTLGSHPYPGMSSQKVIDEIKQGYRLPKPEHCSDNIYQIMKDCWQEKPEDRPDFAGLHTTIDDILADAAGYLEMGNVNLDDYMYLKPGQGSSSMETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMP4</accession>
    <name>A0A914AMP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064786.1">
        <property type="nucleotide sequence ID" value="XM_038208858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208858.1">
        <property type="protein sequence ID" value="XP_038064786.1"/>
        <property type="gene ID" value="LOC119735155"/>
    </dbReference>
    <dbReference type="GeneID" id="119735155"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="152" mass="17299" checksum="C76CF223DF663F97" modified="2023-02-22" version="1">MGDSRIPDDHITASSQYNWVDHAPWKARLTTSGHSAWCSKQAVDPTPWIQVDFSRDLYVTGLVTQGRDIQYDQYVKSYEVAFSGDGQVWRPVTNASGTAIKFAGNTDRVQRTTTKFDDVLRTRFLRIVPKEWNNGCCMSFEVMGCNRTELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANW0</accession>
    <name>A0A914ANW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Out at first protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065124.1">
        <property type="nucleotide sequence ID" value="XM_038209196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209196.1">
        <property type="protein sequence ID" value="XP_038065124.1"/>
        <property type="gene ID" value="LOC119735491"/>
    </dbReference>
    <dbReference type="GeneID" id="119735491"/>
    <dbReference type="CTD" id="220323"/>
    <dbReference type="OMA" id="CHYGLSL"/>
    <dbReference type="OrthoDB" id="5947176at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026315">
        <property type="entry name" value="Oaf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053897">
        <property type="entry name" value="Oaf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053894">
        <property type="entry name" value="OAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423">
        <property type="entry name" value="OUT AT FIRST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13423:SF2">
        <property type="entry name" value="OUT AT FIRST PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22873">
        <property type="entry name" value="OAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14941">
        <property type="entry name" value="OAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Out at first protein BRICHOS-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Out at first C-terminal" evidence="4">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32730" checksum="0F71DD08D30DC432" modified="2023-02-22" version="1">MASVRKKKELRQNQFSELRFSCPVILAQLFVTLTCISIVSCQLVINVKNKGGDLIQESLHGNPAENTISLKFQKLDGTLLSMLIDFKSEVQIFKMIVLGEEERADESQYQTMCFIFKFIKSEFISADAMSKLRQKNPGTIRNPEEDKGEERLIMNLGVDLGQASRFSPWVFNVCSEAKGRIFTRDSDLKAWAAGNNLTYTSRLEATHSFPLFTTSRCDETKDTGAACVCRLPICIGWYPCGLKYCRGRDSAGKTVSYRCGIKTCRKCRVFDYYVEQKLNCMWESVNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR91</accession>
    <name>A0A914AR91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066173.1">
        <property type="nucleotide sequence ID" value="XM_038210245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210245.1">
        <property type="protein sequence ID" value="XP_038066173.1"/>
        <property type="gene ID" value="LOC119736213"/>
    </dbReference>
    <dbReference type="GeneID" id="119736213"/>
    <dbReference type="OMA" id="AICTACY"/>
    <dbReference type="OrthoDB" id="5957171at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="33503" checksum="5A352F08D912DF5D" modified="2023-02-22" version="1">MTENFITVLQCCLSGVCAVATVENLLVIAVFAGTKKLRMKFYAFILNLALADLVFAIAAMLGTWIKTPVISACINATFAVSILTILAAAINRYLALSLMPPARYDSLVTGCRLVGVCIVLWCLGLGFCLLTSDAVIKAVLNGVQYVGLSLAVCIVWVITALVYFLAFRKIKQYTPPLASAAAGTSANAERDQTRVQQTRRLLVVFVLILAVSFISWVPISLLRVIRFFDRPFGQSDNFQVYIWGSRLLYTLSTAINPLVYWWRLDSFRERFHSLFCRCVSKAKPSEIEADLTTNDKTIAESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARI0</accession>
    <name>A0A914ARI0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066660.1">
        <property type="nucleotide sequence ID" value="XM_038210732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARI0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210732.1">
        <property type="protein sequence ID" value="XP_038066660.1"/>
        <property type="gene ID" value="LOC119736720"/>
    </dbReference>
    <dbReference type="GeneID" id="119736720"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100291" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12341" checksum="E9F3155396545C73" modified="2023-02-22" version="1">MEWVWGCILLVLPGGLQISAQTVSASEDPNSVFCHSNPCQNNGTCVNMLRPGSDRSLSVCKNGACYKLILEKKTWEEATLACNVMGSSLIAMETTEVQGDFVNTIKDHHLHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASF1</accession>
    <name>A0A914ASF1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066384.1">
        <property type="nucleotide sequence ID" value="XM_038210456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210456.1">
        <property type="protein sequence ID" value="XP_038066384.1"/>
        <property type="gene ID" value="LOC119736438"/>
    </dbReference>
    <dbReference type="GeneID" id="119736438"/>
    <dbReference type="OMA" id="LACITQD"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="34814" checksum="B65F6B91DCA6F0BA" modified="2023-02-22" version="1">MSVEVKPDGTEGTPPPTPPPSNPFQPPVMPMQAAVSLKLPPFWPNDPTLWFTQVEAQFVIRHITTQETRFAYVIGSLQPEVAQEVRDILITPPSTDCYDKLKSELIRRTSVSEQKRLHQLLTSEELGDRKPSQLLRRMHQLLGDNKLEERILKQLFVQRLPHTVQSILASTADTVGIGALADLADKIVEVSAHSTPASQISTVSSPPLHPPQRHASPEVLTLHAKVDDLTRQVQALTFQLQGMQRQGRPRSSSRSRPRQRSPTPSADNQPSGDRQCWYHWKYGTNARKCTSPCSRRTEPQRNQENGQAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASP0</accession>
    <name>A0A914ASP0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Thromboxane-A synthase</fullName>
            <ecNumber evidence="6">4.2.1.152</ecNumber>
            <ecNumber evidence="27">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="33 34">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 31">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="6"/>
    <dbReference type="EC" id="5.3.99.5" evidence="27"/>
    <dbReference type="RefSeq" id="XP_038066484.1">
        <property type="nucleotide sequence ID" value="XM_038210556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASP0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210556.1">
        <property type="protein sequence ID" value="XP_038066484.1"/>
        <property type="gene ID" value="LOC119736542"/>
    </dbReference>
    <dbReference type="GeneID" id="119736542"/>
    <dbReference type="OMA" id="MYITEEQ"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="20" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10 31" id="KW-0349">Heme</keyword>
    <keyword evidence="17 31" id="KW-0408">Iron</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="22" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="31" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="16 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="219" mass="24599" checksum="77B7264CC079E44C" modified="2023-02-22" version="1">MYITEEQRAAHKEGVVFKKTRVDLLQLMLNAHNDPEVDQEDTPSSDKAKGKGVVQRKLLSTEDVMAQSLTFFLAGYETTNTLLGFTAYLLATNQDTQEKLHAEIDNLAPTRDNLGYDVISKMEYLDMVINESLRMYPPAVMFSPENKASIKPCTFMPFGLGPRNCIGMRFALLEAKMALVRVMQQYRFDVCSETEIPPTVGKAGLMSPKNINLKAIPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVB6</accession>
    <name>A0A914AVB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068040.1">
        <property type="nucleotide sequence ID" value="XM_038212112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212112.1">
        <property type="protein sequence ID" value="XP_038068040.1"/>
        <property type="gene ID" value="LOC119737612"/>
    </dbReference>
    <dbReference type="GeneID" id="119737612"/>
    <dbReference type="CTD" id="494188"/>
    <dbReference type="OMA" id="AFACVTM"/>
    <dbReference type="OrthoDB" id="9858120at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22112">
        <property type="entry name" value="F-box_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="51472" checksum="6710A9D1A7C41669" modified="2023-02-22" version="1">MHRNATSTQITTRACRRSVRLENKDYHSRMSWCVQSDPLGFFALLPTELMYHILNTLRIEDLGFLSVTSKAFRDVIIEYTQSTSGLKRLQLRQTAPSRRTASKRAVCNNLVNHFKNVGLLLKRTTCLFPTRERLKTVEFIVSQLQCVHRSFTCQALSCYGNLLSTFTRGWEERECLRAYITISENQSMISKILIMLSGNPGSNPAVEIKTRRFFRHVLLDQCKTMEDLSMWLHFILKPFPMVHQARLLYLLYGPLCPGTDAVFWDCMRETSVGDRQTRSSTIAPLGEIAMALKALVNHREWSDDDVISVLEELTGCPDEWLIENVARLLILCGEPMALKVLGSKAINGKMNELGSIVVAFSVVLYDEGLHMSWLIKVVQQLCGMMKTAQDIKSFLASVTATYKDFIIALMYSPEEEVTRMQFQLHHVAMAQADFMQAMMQQLFNTQTAQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWB7</accession>
    <name>A0A914AWB7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068037.1">
        <property type="nucleotide sequence ID" value="XM_038212109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212109.1">
        <property type="protein sequence ID" value="XP_038068037.1"/>
        <property type="gene ID" value="LOC119737638"/>
    </dbReference>
    <dbReference type="GeneID" id="119737638"/>
    <dbReference type="OMA" id="NDQENQC"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000010">
        <property type="entry name" value="Unconventional myosin-Ie"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF729">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="13"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="15">
        <location>
            <begin position="724"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="912"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1104" mass="126282" checksum="9DE556BBA6F76589" modified="2023-02-22" version="1">MTYHWQSNTKKQSGVEDMVLLTKIQESSIVENLKKRFMDDWIYTYIGPVLISINPFKQMPYFTDKELDMYQGAASYENPPHIYALTDNMYRNMLIEYENQCVIISGESGAGKTVAAKYIMGYIAKVSGGGAKVQHVKDIIIQSNPLLEAFGNAKTVRNNNSSRFGKYVEIQFSRGGEPDGGKISNFLLEKSRVITQKTSERNFHIFYQLLKGADAEMKEGFGLTNPDYYYYLNQSGTFQVDGMNDAMEFNDTMSAMSVIGISEDDQSSVLNCVAAILHLGNIQFKEQGNYAVVAQEDFLDFPAYLFGVDKELLRSKLISRQMDSKWGGQTESIKVTLNTEQAAYTRDALAKAVHARVFDFLVESINQAMQKDREEINIGVLDIYGFEIFQVNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVNEGIKWNPIDYFNNKIVCDLIEEKKSPPGIMSILDDICATMHAKSEGADEKLLQKLNGAVGTHQHFQGTGTGFIIHHYAGKVTYSIDGFCERNRDVLFPDLIELMQSSESHFIQRLFPEKLETTERKRPTTASTKIRTQANLLVTRLMKCTPHYIRCIKPNETKRPRDWEEKRVHHQVEYLGLKENIRVRRAGFAYRREFDKFLRRYSVITPETWPQWRGDVRSGIKHLMNAVNMEPDQWQLGRTKVFIKAPESLFLLEEQRERKYDHFARILQKAFRRFNAHKHYLRLKEQASDLLYNKKERRRYSLNRNFAGDYIGFEHNPLLQALTQRRERVEFSDKVNKYDRRFKVTKRDLLLSARNIYLIGREKVKSGPEKGQIKDVIKRKIPLEQVQSVSLSTLQDDIFVLNIQNDFSSLLESVFKTEFLTVLSKKYRDAAGRELQLDFRDTINVIVKKEGWGGGGTRTVRFAQGTGNMAVMKPSGKVMTVSIGPGLPRNSRPGIRQTQVTGADRANAAPMGNGPPRRAPGKAPGRPPPSASYAQVDKQRRSPQTSPQHKPMRRSSRRMSGDHPSLPKGGAAKWAKNPKMAHLNTAFLQTPDAGVAGFKRQSLKRPPAQPKPKPLPKPKLPKCRTLYAYDAQDTEELSFSPGETIEIMNEDSSGWWRGRLGRREGLFPSNYIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY92</accession>
    <name>A0A914AY92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ERI1 exoribonuclease 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exonuclease domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ERI2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069115.1">
        <property type="nucleotide sequence ID" value="XM_038213187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213187.1">
        <property type="protein sequence ID" value="XP_038069115.1"/>
        <property type="gene ID" value="LOC119738337"/>
    </dbReference>
    <dbReference type="GeneID" id="119738337"/>
    <dbReference type="OMA" id="YESTCWE"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000062">
        <property type="entry name" value="ERI1 exoribonuclease 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="563"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="688" mass="76136" checksum="DEA46F1F54830FE6" modified="2023-02-22" version="1">MKSTKELARQLGLLRRRSTTSNQQSRDARRVKKTNQIFSYLIVIDFESTCWKDKKNVSQEVIEFPAVLLNTSTGSIEAEFHTYVLPEENPQLSAFCTELTGITQDQVESGVPLRFCLSKFSRWLTKQENEKSIAYNSGDEGKKLCTFVTWSDWDLSVCLHYECRRKQLLKPSALNSWIDLRATYKNFYERKPNGLHGALQDVGIEFRGRQHSGLDDARNTAHLAWRMMCDGCLMKITRTMPGTQQLKRKQTAQLPEQPTKVQVKQNTGKERQEPDSLCVNTHRGIESEDRLISHTQGICDEFSQSGKIRNTSLSSSIHFKIWEDATQPATVHSVIRPETSLPSLKDNEIGLNSSKNEGTEFFPVQTSLGAKIQSENRGMNKGKTHDAKLQSLNKGKQALFVRNTFNSRSSNCNGNICGNKDACSKSDVGENALQHTASHNLVNKIPTRVKSLVNTTTNAVPTRKNNKQFAGSARTGLQSTVTSPASLHGSSTSPPTPVVFKTPLSTPLHKQSVKPSPSDGFKTPYAPRTCTTPGSGSFKTPTQPSNTCTTPSLMGGKITPPMCQCGRRAKRRTAQSPGPNVNRVFYSCASGRRSSEAGLKDVTNSKKGCGYFKWESMVLAEKQRLVATSPVNQVSPWSAQRQSAVTSTSQLKKSAAKFSTSKTVTPVGFTGKRLGIAMRAVLRQQNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYS1</accession>
    <name>A0A914AYS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional apoptosis regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068406.1">
        <property type="nucleotide sequence ID" value="XM_038212478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212478.1">
        <property type="protein sequence ID" value="XP_038068406.1"/>
        <property type="gene ID" value="LOC119737851"/>
    </dbReference>
    <dbReference type="GeneID" id="119737851"/>
    <dbReference type="CTD" id="51283"/>
    <dbReference type="OMA" id="GNDQMPT"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16497">
        <property type="entry name" value="RING-HC_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="53461" checksum="96129D91E67D149B" modified="2023-02-22" version="1">MKVKVEAPCYEIVVSPMDVDNPEGELNLRPGNYGNHVSQSEDLTMSSEHLSPMSESTFTCGCCYEIMVQPTTLNCGHSFCRLCLARWWKTQKRTTCPECRHPWTGFPHVNIILRNTMEKLCTPQLEARAATLQTPTSASILEEFEQFGQELEKTQTKGMAAGNRAPRGFVWGVLTTLGVVFVVQLLLNWGSGDSNMLVYKPLSTWKSEEVSDWLQELGSWAGNQYSQQFLEHSINGNLLMGLTEESQLEDEPFNIKNVLHRRAILAALERVKERGAKPPRDLWEYKSLHRGLATFLLFVVKEFPRITISSMYIFYYEDIFLPFIHITCPGSQSEDIVEGMQLPKNYNDTIEWDQWAEFIPKFIFLPYYLMAELSWAWIDVNFMPVIFILANCVFLTMIEAKTVRKVLKHGLKVLIPTIKKPANTMLFILVSVVMWPLIPSIFCDFAFYISLYYSPCGNFYTIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ05</accession>
    <name>A0A914AZ05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068754.1">
        <property type="nucleotide sequence ID" value="XM_038212826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212826.1">
        <property type="protein sequence ID" value="XP_038068754.1"/>
        <property type="gene ID" value="LOC119738096"/>
    </dbReference>
    <dbReference type="GeneID" id="119738096"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="115"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30457" checksum="9A590FC802DC44FC" modified="2023-02-22" version="1">MLVTQMILSSFGEVLDVILESIRFIKTAKQGYYCTSFHFQAMPCTITQEPDPHTGRYRWLIPAVDPCECTQIGMGGFSTFVPYRPYEVTYYDTFLISSDPGEIQQWLNCPGDSPCSVEGTLGMEDGRIPDQSITASSFFRNLTAFGPVRARLNLKGNAEAWCNDDVTDNISPWIQVAFNGTVTITGLITQGRGDYDQWVTEYRVTNSRNGGQSWNNVTDVDGKPIGFPGNNDGNTVVTTRFPFALRTRILRIRPTAWYVHCSMRFEVIGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ90</accession>
    <name>A0A914AZ90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068574.1">
        <property type="nucleotide sequence ID" value="XM_038212646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068575.1">
        <property type="nucleotide sequence ID" value="XM_038212647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068576.1">
        <property type="nucleotide sequence ID" value="XM_038212648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212646.1">
        <property type="protein sequence ID" value="XP_038068574.1"/>
        <property type="gene ID" value="LOC119737969"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212647.1">
        <property type="protein sequence ID" value="XP_038068575.1"/>
        <property type="gene ID" value="LOC119737969"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212648.1">
        <property type="protein sequence ID" value="XP_038068576.1"/>
        <property type="gene ID" value="LOC119737969"/>
    </dbReference>
    <dbReference type="GeneID" id="119737969"/>
    <dbReference type="OMA" id="CVSANCK"/>
    <dbReference type="OrthoDB" id="10261083at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="998" mass="109871" checksum="530A858DCD7E62DC" modified="2023-02-22" version="1">MFKSEFQGGAYVEVFSCQGKEPLAKWKLTGAASIHKVYEKEAKSFVHVLEGAGTSTKIQLPKDVKQTLALVQRFLVLQVFVPLGQDFSIELGVSDMGNNKRRLLFSTAQKEIAATPLHAKIPLTVVRRAMWLNLCIDLVSMVSEAFRLQTYKSLDSLIVCASCHLRKVFTMKTQPPDDTDDDDQYDCNPPTNNMELDSIPRSCQFSADVSCQTQVLNMNKLRHAEFKLKPDSRPGSSTEPLDLNSSMKGRRNRPTHIAFGSKVPVPAIGAGKKPASAGSQREGSESASSRSSRSSHSRALKQEGDPLVSDRSVSAKKEVDRLTVHSGSRQRQASDPGTEVADLESRVDKGTLKGSNTWSAGLEASKEDNFVQPHPPRQKSGDKSRRVVKVRPNSGKRERGDSMSAGSDTSTSGRSGHYDRSRYADNGGSGAQRRDSEESSDADRPSRVSDAAILKYASSRIKAGADVNVNGDESKGSEKPMNKNGNHQGVRPTVDSLSESDELAGRSNQKGRTQRRKKKADRPPPLSRMDSLSESEEGQRQRGKGRSHGDRGEGGGGVARSGRPEKREGGGSSRMEQLSDISTTTDSGVTDLHSAATSRGAEESRDQTRPKPPNTSRHGNKQSRAEGNKSSNDPLAKGNGKIYTFTSPPRSAPLRPIERSRHLEPKKLQLQKISEGPPRISPTPPPADDDRPSPRNSSPSDRLNGEGGRTRYNAIFRRTPSPRQIRSLQLSSSGEFSDHKRNDVDSPKPTASMSPQQTRKSLLTASALQSHSRASAASPARGSLSRLSIHSKKLREIPKDDPRLSDDYDWMKYQSNNSSLASSLEANMLASLRRQQLEEMYEEDPNDERQQANNSFDIHNYGDDDLSSSSDDTATTYSTFKPPDALQKAHRYQDEMHFPSNTNPLTQSNPRDWSNLFSPPIVLPSEKIKADHEAAILSPGKDMPTAFRTDKARTKSTSSDDPGRAFTESEEDEELDLLYDPCLNCYYDPRTGKYYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0U8</accession>
    <name>A0A914B0U8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069118.1">
        <property type="nucleotide sequence ID" value="XM_038213190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069119.1">
        <property type="nucleotide sequence ID" value="XM_038213191.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069120.1">
        <property type="nucleotide sequence ID" value="XM_038213192.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069121.1">
        <property type="nucleotide sequence ID" value="XM_038213193.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213190.1">
        <property type="protein sequence ID" value="XP_038069118.1"/>
        <property type="gene ID" value="LOC119738340"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213191.1">
        <property type="protein sequence ID" value="XP_038069119.1"/>
        <property type="gene ID" value="LOC119738340"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213192.1">
        <property type="protein sequence ID" value="XP_038069120.1"/>
        <property type="gene ID" value="LOC119738340"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213193.1">
        <property type="protein sequence ID" value="XP_038069121.1"/>
        <property type="gene ID" value="LOC119738340"/>
    </dbReference>
    <dbReference type="GeneID" id="119738340"/>
    <dbReference type="OMA" id="LHDGKHC"/>
    <dbReference type="OrthoDB" id="6426227at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04714">
        <property type="entry name" value="BAH_BAHCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20469">
        <property type="entry name" value="Tudor_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052429">
        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048924">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056841">
        <property type="entry name" value="TNRC18_BAHCC1-like_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21744">
        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24912">
        <property type="entry name" value="SH3_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="3049"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2478"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2699"/>
            <end position="3009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1630"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1676"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1940"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1954"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2007"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2104"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2141"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2165"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2176"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2207"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2292"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2304"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2375"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2428"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2750"/>
            <end position="2760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2776"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2799"/>
            <end position="2810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2811"/>
            <end position="2820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2821"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2843"/>
            <end position="2859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2860"/>
            <end position="2873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2874"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2897"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2939"/>
            <end position="2949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2977"/>
            <end position="3001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3172" mass="340613" checksum="57198850126DF33D" modified="2023-02-22" version="1">MEGRTGLPVSGTPPFPAPVLPPHGTVPAPAVSCSDSTVLSPVFADLPGGPNGGATRTSSAVAAASSIASPGHANYQGKLFSSSVAALGGGSGFSYLGNYIGPSSTDSFKQSSGVVAQPASMNQYWLPNSEGYAGFSVSGAHSYPPYLTALNSLPGPGTQGLLAVSATAKSESQRIPASHHIRSSDLWEGPPSKLSKTSPHILKEAALSPKTPTHPPAKSRHTSGSEDRKASKHDSSRSKNKDRVLDSTLVEEKKESAASRCSKTSSKEKGNCCDSTPKTEQNLQSDSRQDLQTKKSEKLSEPKQKFPSNPGTLTIEINNGEELSNSASKCNGDASVLSPKKESSKGNPSLQASSPKLKESSSEKRKKASKRKDLSVDVNGNAVLSSIPSVAEKKIAPPAATIVCISENLTPVASFASETLNASNSAHLPAGAESTNKNQPIQMDASTNGNNRMSTSADTVPLTASPLSSITVPSSEKLSPRSLPGKVSSPASAPLLSTSPRCSSHGTDSSAAVSPSGKTTGGVISVQTSSPGVIMSTSSLGDCTQRTSTSGDSPTAGADVRKINSPVDIPTSLNSSDISHPKACPIGAGPATSNVPTSSPLGATSSVANPSLAYPTDVNPKGVNATGVNPSGTHPIGTNPKGTIPIAANPTRASPTRASPQGTFSSEGRTTEANPTGANPTGSNSAGLSPTGTKPTRSSPLIIGSLSSPHSVISGDLSRESPVEKEKLPSPRSLVTTTALSTCVTSSVSKPISFPAHGSLPSPSSQTQPSYISHLPIYLHGTGHLSLEREVGRETPRDGSKVHATTFVPALGEFIPGPASSATMQVKESKTKTSTNGKESNHGPLVSDKEKEKVSLKKEPAKVGTSLSTKEQIVVLPKGDVGTERTKVGSSHQDCGAKIKESLDSKSTLTKAKGEKSDKHDKLKKGHSSSKPSHESRDHHLSPSELSASGKDRVMEGTHRTPSDSIHRETCRTSDAAIISTTPSMHSYPHHMAGFSLPLSSMVPSSREGNKLEAPPTLYSTEEQRRYLEWHMAAAKRGYCYEHPGNRVSSSEPPKLDPSMMHRTPHQPSFPSPRTDSRPEPMPEHSRGRDYPSYTAPQESMLRSVLTAGMHQAHSEAQRTSPGSSSSGSGTSGKAAKQSSETKTENRNKSVSHGSKTSSDSLGSQGRSTPGTKGSDGRNPPVGIAVAQKRQDSDSVSQGRPSTITTQRNSPHVGSDEAEDRGARSRAIHGVDRDGKHREHSPRSHREATDLLPPTKYHHHRYPGDLGSNLIVTGGASLGPSPHHFDPTEGRMTPSHPAHLALPPPWLPRAPGPPHAPSLWLGHPFGLTTPPGTALHAAAGEGASSHLQVPPAGLQVARDPATGHLVLVPQVPAVHSDSSVPPNLSMWPYLVPPHLQPHSHQLQQLVLNQPSFAPPLPHQASHPLTHRQDQPLPNADYHFALQQHQEALAQWYRQDEQRQREEQRRREQQSRKSSGGGGEKTQSDNKSHKSGSGGEPKSESHTEKQPASHHHDVLNLKIPPHAPYLPGVSLPGQPPVSYVYPPQQVQYLYNHAGVFPAVSCSSSPRTESGASTASPKQTTTKSSTGSDGNKNTKLDSSLKTALKSISVQTSPSETPASVDDSNETKPAASEETEENEEMDTSLRTEDSEDQELIIVDVVNDDASDSPMLESEKINQENKNSSTQANSETEPAVADTKLVEKSRTSAMIVDPRTNMLSSAVLSSTEIQTDMSLDPAMTQKMISETVIPITPLTTPPLDTEVPSLETPPAPIQEEPGKDSLISNVLTTTQSFASRMEALDQDQLAAIEGIALLSEVAEQKVFSVCNDNDKTNAAQTSQTRDDSYLLDARHQDNGTPLQGNTASALTSASGNTLQLISQSCPTSPTDFIFKRSTSSEGVDSFASPGDILNPNEVEMTQRLAELQRKYQEKKRELDKLQRKKDKKDKGSRSLDQDRRRGPGRPRKRKISKESHQESGPCPIIKSSTAVLLEAAASLEESSPFLVPKKKKKKDREDKEKGKTEDKKKSSKKDKEAKAGHSETSKSKKRKHKSKEDVQDSSPTSEDVSSSSSGGKSKSKSKSKSKSSPSLSPSSKDTNKQKASSKSRKVSLTDSASSDSLAKSGKSPKTSGSIRSPRSQNSSTEFDTDSSSIIWPSTSTTASTSSKIPATKSKSKSSKKKTKEAKVKDGKKDGAKSQGSSDPAEDATMEAIENVIRKSCDGQGSSEKEPARSGPLQHALHIYEDDSDSPWETAMIDAKQKKNSGHAQQKGLALLAGISSQELMKSARPSKESKTSSGKDAGDGKTTDADKSKKKSGKTKKRSISPATSEQGTPKKARKMSPVVFKKEKDFESPSKLPKSTKSVKKKEKTPSEPTPRSTSVVKQEKKDLEEKPFFNEEIWTRRRSERIFLSDISPGASRDASPLAKGHDVAKTPKKVGGPPAKPKGQSESSGGEQGAGSDHSSTANIGSVLDALKTDTLQIRKKLASMSAQEDEKDDVPRKTKKKLSKKRDQGKKSSSKQDGKTDSGRSKHNDDILDSSCSEAENLPLSNFLDRQNPPPPRSCIINKDELQNGLRVLIPIDGLFYAGNVNAIQPPDVYGVILDGERGSRPHVFSQEQMLQETFVDVKPLSTRFVPEGTRVCAYWSQQFRCLYPGTVVKGTPNPNEDPNFVCVEFDDGDSGRIPVDHIRMLPQDFPIVEFEPIPAELQRKRRRRTSDTSCSTSYKLEKGDTDEGTTASKSKTSSPKKKSKMTESNKSAADQHEMDRISESGEDDVFLPQTQKVQSKSKKSKSHDKSKKSSSKVDSKLKEKKKKKKRKREERRQESGDRKSSKRSSSKSPRRSPARSPSRSPGKSKKKKRKEDRKKKSSSKLSSSNGDSSPKSKSSKKKSSSSSNKRKSHRDDRHSSFCTVETETVYSTHPINGSQVLTEEESASETPTFDNGKGVWNKHRDTRDHSLDDWSSTDSSKDSSSDSDETSSDSLSSKDNTPLTPSRKSRSSILPSTSKMTGSPSPSPSPCNAVAFLPARQLWNWFGKATQRRGAKGKARKVFYRAIMRENEIIRQGDAAVFLSTGRPHLPYIGRIESMWESWGGNMVVRVKWFYHPEETKGGRKSHDGKMALYQSLHVDENDVQTISHKCEVLSVDEYKRYASGKKHKYTMDSEDVYYLAGTYDPTSGHITSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B370</accession>
    <name>A0A914B370_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070769.1">
        <property type="nucleotide sequence ID" value="XM_038214841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070770.1">
        <property type="nucleotide sequence ID" value="XM_038214842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B370"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214841.1">
        <property type="protein sequence ID" value="XP_038070769.1"/>
        <property type="gene ID" value="LOC119739776"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214842.1">
        <property type="protein sequence ID" value="XP_038070770.1"/>
        <property type="gene ID" value="LOC119739776"/>
    </dbReference>
    <dbReference type="GeneID" id="119739776"/>
    <dbReference type="CTD" id="1639"/>
    <dbReference type="OMA" id="DECDENA"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="907" mass="100763" checksum="45278957FA6AD20A" modified="2023-02-22" version="1">MAEKPVRIGSKVEITGKGLHGKVAFVGVTAFASGKWIGVVLDDAKGKNNGIVQGKKYFSCPDNHGIFVRQSQITIEDSPPGSGTVSPGVASPAVSAIPRSGIPKTEKSSPSGKKQPPSPSQKPSEPTAPAEKPLSVRRLAKFSPARRSTESLSRPRVESPVPDPSFAPTSRLPQLSASSKPASGDGSQSSEQVGALKLEVQDLKEKLETLRIKRAEDKLRLKDAEKMKIQMAQLAEFKARMIESKNDQERQLQEAKKEAREATDARERYQEEMSEVAETIEMATLDKEMAEEKCDSLQAEVDTLKERVEELTLDLELLRGEIEQGGTDGASASYQMKQMEQQNARLKEALVKLRDLSNAEKHEHQKALKDKDKIVAELKESKAQKESANKALKEAENQIIELKEQVDAALGAEGMVETLTDKNLELEEQLQELQTTVADLESLNEMNEELQENARETELELREEADMQRSKVAEYQRRMEAMKEAASDNQETISKFRQLTASLQEKNRELLSQQQNAALSQDSQADMPTFDFKAKFLETKAQAKAVEIDMYKLRIDQASQHVDYLCSFMPDQFLRRGGDHDCVQVLLLISRMLAKSDLLVNQLKERAEIPETMNREEVLRNNKGEQLSFTNFLIFIISQLQAILNKYQTALTSCNVALFCKIGTLYPEMSPHETALDYLIDLMRKDQLDETTSQESLLKAIGFFTHLYSVHLAQENVDQTLIMADSVRLVSSATDLVGLEIKKLRVLMQAMQETSDFSILLKDLEGTNADLKTFARMIRRRLPQVEGSDGPTPGPQALVYGGDVQTSLAECCDHLITLVAGLRDLGQGAMKAAGSLADTPEKDKEKKTKQGKKEGLWKVLASCTLQLTATSSSINNYSDTSLHRIPCCFCIDLNTNTGVIYETSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3P1</accession>
    <name>A0A914B3P1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070647.1">
        <property type="nucleotide sequence ID" value="XM_038214719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3P1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214719.1">
        <property type="protein sequence ID" value="XP_038070647.1"/>
        <property type="gene ID" value="LOC119739698"/>
    </dbReference>
    <dbReference type="GeneID" id="119739698"/>
    <dbReference type="CTD" id="340348"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000007">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="302" mass="34098" checksum="5EF4E93631E29A21" modified="2023-02-22" version="1">MNEGRDLAKTHINPCIKYTLFVLNFLLWVFSIGLIIIGVWALIERQNTNHIQIWAVIESQNSTHIKSNQQDIFTGSSIVLIVTGSVSFILGFTGFLGALRENCCLLLFFLLFMFLIIILEGSAGTLAFDYSRAFYLTVDEIVERSIAQYRTDLDLTNFIDFAQRTLECCGGDGGYKDWSLNRYFDCTEENPSREKCGVPYSCCMKTEDANGDPNIINTQCGLFTREQYLVPAKVSNEIHTAGCVDKFLVYLSQKSYIVGPTALSVAAVQLLVMLLALRLHQQIKLECSRYHKCKKRGINNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B447</accession>
    <name>A0A914B447_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070271.1">
        <property type="nucleotide sequence ID" value="XM_038214343.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214343.1">
        <property type="protein sequence ID" value="XP_038070271.1"/>
        <property type="gene ID" value="LOC119739400"/>
    </dbReference>
    <dbReference type="GeneID" id="119739400"/>
    <dbReference type="OMA" id="IREDYIL"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002692">
        <property type="entry name" value="Zinc finger, NFX1-type-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="1765"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1853" mass="211857" checksum="655A98866B9F0865" modified="2023-02-22" version="1">MDANPFRVRGHGANQGGAADGRRRQENDQPRDQGNPGRFGNQRGQERGGGYGWGRGQGRGQGRGQGRGHFRNVGPNHQDHRDQEGFQDGQGARPRTQRERPIRQPGYRMLQSLLDEEKCPAEVVQELTSFGKGLESLLREREIRRDMMVLLIQVMDRVCDCEDSPQSVVRVLNAIVDTDFLSRNLSQHINSMTTEFDDRYLMKVPDLIGSILKLMQTLIQKVQNTMKDVHVVLTLIDSVARTLETKGYPLESETKVLLSQLLLCCQQREKEKAHRSQRQRTDQEAPPPNDFREIPIFPDVAEITTNADNYLRPNVVHGRYRDLNHYLDVQFRLLRQDFLEPLKLGIAEYHVSLAQTNMKRKLRDIRIYHDVGVHFPICTNEGITHRVSFDISKLRKVRWQATKRLTFGSLVCLSKDNFQSVIFATVANRKPEELEEGLVDLRFQDMARVSEIDSSDCFIMAESSAYFEAYRHVLQGLQEVNDNSLPLQRYIIEVSSDVKPPQYLRRNRFSTYDLSSLTHTEEEGDKDDEGKVLRDLRRLSTKASAVQVLTPSSWPRAETLHLDESQLKAVHAALTQELAVIQGPPGTGKTYIGLKIVQALLHNREVWKEDDEPNPILVVCYTNHALDQFLEGIMNFNQNIVRVGGRSNSEDMKDKNLNFLKREQRRKRDVQRAVHIRTSNILREMYSLRQCMEVSQRKVEKSMKGIINEDFLQPFMTKEHYATLTVIFRETGYNRPTSYILEWLGLSGTFRVATGQEVGIAAFMGQDDEPEEDDQEEDEEFAVAEEADAIAEQRILDDKEDDMFLFDEDPQENHLVLDIDSLVAAQPEQEGWQMQSHQKKRMRKMLLHNLRKSEKMTERDAGRVKNVWAIGDINSRWKLYRYWVSEYSKNERRRMEIVQEKYEALSQELKEVRVEEDLSILRRASVIGMTTTGAAKHRNVLQRVGPKIVVVEEAAEVLESHIVTTLSAECQHLILIGDHQQLRPNPTVYRLAKDFDLNISLFERMIKNGVPCQSLVQQHRMRPEISTIMRNHFYPDLKNHESVRSYPKIAGISSDVFFLDHDIEEEEVDDSRSKSNTHEAEVLVALCKYLIQQGQYQPTQITILTTYVGQLFNFKRCMPRSFFNGVRVCAVDNFQGEENDIILLSLVRSNQEGNIGFLKVSNRMCVALSRARHGFFCIGNFQGLAHGDSLWKNIVQEMRGRGLLGRYLSLVCHNHPKTITRVSTSKDFLNVPEGGCSLACAFRLDCGHSCGMLCHPTDSEHKEYKCLKKCEKVLRCGHRCKLLCFQKCDRCKEKVDKTLPCRHQKKIPCYQNPDSATCLEQCMKKLPCGHRCRRKCGEEPCTEICLETAFRSDWPCGHAVQVKCSDGPEKCPKKCGVELECSHQCQGSCGACKRGRLHVQCQQKCNRTLVCSHQCTALCTRECPPCAEKCKNRCVHSKCPNRCGDPCALCQEPCAWRCPHYRCSKKCSEACDRPPCNRPCPSRLGCGHPCIGLCGEPCPDKCRVCHRDEVTEILFGDEDEPDARFVQLEDCGHVFEVGKFDQWMEMKNEEQKSIQLKACPRCNTPIRRNLRYGNIINETLADIELVKERIFGTKREIAAKKVQVRTMLYSVATDVDLDTFADRISRPMGLAELTTIENQLLLLKDMAKAKKKATDVARDVPQYIRKIEVHRKNLLELEKWLLKPRMYLSTQELDDCSREVQRLSMCFSFFFIKAKVQAAASNSNKASVQIVEDLLLSGKPLEENSVKTVKTLLEKLRRECTGLGISETERVMIVKAMGFSKGHWYKCPNGHCYTIGDCGGATVESTCPECKAAIGGTGHRLVSGNALASEMDGARYSAYSEEAFMENYDLREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4Z7</accession>
    <name>A0A914B4Z7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071326.1">
        <property type="nucleotide sequence ID" value="XM_038215398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4Z7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215398.1">
        <property type="protein sequence ID" value="XP_038071326.1"/>
        <property type="gene ID" value="LOC119740180"/>
    </dbReference>
    <dbReference type="GeneID" id="119740180"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="36914" checksum="95FF3F4A5B1EB0FE" modified="2023-02-22" version="1">MSVAEQIQALMPDLINGKRHQQLEEELAESDQRTGRHVVNGIKFPFHVTRSNLEAMKTFEVRDDDVFVFSYPRSGTHWMLEIVGFILHDGKDDFDRTFMTNGLEFSLAEDPTKVESVTPGYKTYAAMASQRCILSHCLESYRPPQILTKQPKVVYVARNPKDTLVSLSKWAPFWDFAEFFWAFSLGKTVFGSWFDHVLSYWRQRNNENVLFLKYEDLHKDLRGSICKVAKHLGKDLPHDVIDGIVERVTFGGMLKTYQHLEEERGEEGKRMTSHKGNTFLRKGKVGDWKNHFTVAQSALFDKIYALRMEGTGLDFDFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B564</accession>
    <name>A0A914B564_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071386.1">
        <property type="nucleotide sequence ID" value="XM_038215458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B564"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215458.1">
        <property type="protein sequence ID" value="XP_038071386.1"/>
        <property type="gene ID" value="LOC119740227"/>
    </dbReference>
    <dbReference type="GeneID" id="119740227"/>
    <dbReference type="OMA" id="QTHTEIP"/>
    <dbReference type="OrthoDB" id="10070446at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01268">
        <property type="entry name" value="PTB_Numb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000031">
        <property type="entry name" value="protein numb isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010449">
        <property type="entry name" value="Numb_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06311">
        <property type="entry name" value="NumbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017607">
        <property type="entry name" value="Numb/numb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="97"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="679" mass="74518" checksum="8CE893FF008688C1" modified="2023-02-22" version="1">MGRLKSFFFGSSHGRHKYNKNPPPDTGPASPGPSAEANPSSSTSQSPASTPKRNSRLRRSLSMKKLRSSFRRKEHAHVPAASKPHQWQQDEKLVRAGSCNFPVKYLGSIEVTESRGMHICEDAAKQLRANTKKKVRAILWVSSDGLRVVDEESKGLIVDQTIEKVSFCAPDRHNDKGFSYICRDGTTRRWLCHCFHSLREPGERLSHAVGCAFAACLERKQQRDKLCGVKVEFDVNKTSFTRQGSFRQATMTEQMEEAAAREDEKENQEQDLAGPAPNMPFARPRQHASEAMLMRQGSFRGFPNLNIQSPFKRQLSLRLNELPSTLQRQQNVLHTHPEMPSEEETIEQQSEASPLGTPTSPTASTSFPQQQQQQQQRPVPQQQQQSFLKQQQQQPSQVVSISAACQELSDGLFELSSKEGYPAQPAQLQQQQPQVRNVMPPAAGAIPAQPTTALQQHPVPQQPMVTTRHPMATQQVLAQPETNPWAPPPQPQVGPNPWDPASAQMAGPNGISQAEKWLKQTSQTVSTPYGVPAKPPGLGPAGEQRMGPNAAAVSPVQNGYSSVSHHHQGIHLQNATYEAQPMAQVPAGNFNNSATAPVYIPNRPQQQQQPVTAGGNVGISGGWTSDLSRTLPDSGAQAGTTNGYSSSFEARWESLPSNQTPVMANNPFANATKAFEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5F3</accession>
    <name>A0A914B5F3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071313.1">
        <property type="nucleotide sequence ID" value="XM_038215385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5F3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215385.1">
        <property type="protein sequence ID" value="XP_038071313.1"/>
        <property type="gene ID" value="LOC119740170"/>
    </dbReference>
    <dbReference type="GeneID" id="119740170"/>
    <dbReference type="OMA" id="IAVITCR"/>
    <dbReference type="OrthoDB" id="5977853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15059">
        <property type="entry name" value="7tmA_alpha2_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF189">
        <property type="entry name" value="ALPHA2-ADRENERGIC-LIKE OCTOPAMINE RECEPTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="52"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="413" mass="46409" checksum="05A184DB203A3B45" modified="2023-02-22" version="1">MEYFNSTENWTANSTELTPTVTYPFPPSGYHNAHIIVWSIVVGLIIIGIVFGNSLVCISVVRVRALKGTQYRFLVSLALADLMVGILIVPLSITNELLGCWVFGTFLCLMWKVIDVLACTASILNLCLISLDRYYSITRPIKYAKWRTHRRAYFMIGAVWTLSFIISVPPLFGWRNEDKTVNGYFLCEVSSDPGYVLYSTMGSFFIPAFVMVFVYIRIWGAAKKHARTSLGQGIGDPRPSPSQAGNCGKSTAYELVDTDEASSQAAGAMLRVDKNRNNQNGGKLSPQEPPGSRRFTNNSMLSPNSASSDIRRRTSSCDYREVDRKRRKVAQARERRATVVLGIIMGSFLACWYPFFQLYVIATVCGDACNIPDFLFKFVFWIGYCNSALNPLIYTIFNRDFRKAFKKVLGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6N4</accession>
    <name>A0A914B6N4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038071470.1">
        <property type="nucleotide sequence ID" value="XM_038215542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215542.1">
        <property type="protein sequence ID" value="XP_038071470.1"/>
        <property type="gene ID" value="LOC119740277"/>
    </dbReference>
    <dbReference type="GeneID" id="119740277"/>
    <dbReference type="OrthoDB" id="10067432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="607"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="853"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="912" mass="99381" checksum="57E10E41A4C7CA9D" modified="2023-02-22" version="1">MHHRQCSAAMATRPASYSNQPLPIPGTPQFDWDRLQSSSHPAPRSDNLITSQKQKEVTSLVANYGDGSLPASAPRNASFRNSSVCDLPSFPSQGQGAKMRDKISSDEEVGIPNADPLTSISRGDGKPHEEGRESGDHGCGWESISVPVSPSPSHQSVSSSSKNSSPSQNVGSETDVEDFIYNVDGESSSVSSMSDSSWAMPNSEADVDVDSFDEKTIADKSRQRFTELPPLRQQRLALKMAPAFALKTSYPEDFAHWLTVVLSCIERRDVMRRMQLVSNYKTPFTRKEAWEIHANAAKAKDIMRQLNQIISLSTKDEESSIESLQLASPANPVKKDSEIEGDRRTSSATPQVPKDAWSSRQVASSKDSEPSASITAKTKFETTLKEHKEKVEKSDSDQEEVTPAECPESSISKLSEMMSTESKPWDVVNKASPCAHLPTISKKSSSNDASRAASHAQKDTLSLAEAASEKGAEYTSSMNAKKYIVYAQKEMDEIARKPEETEKSDSDRPSGSPASLLPKLSDKTHTSASLRVVVNKASIEENHHSPQPKISKNSSWKDVATTDNTSSTANASSKSPQATQSPQQGLPELTAYPSIDPSELEFIMSDNGKEVALRSGSCGGVLLMRHKADNTLLAVKVLVKNFSFLQHEVAAMHAVRNCPFFPKFVGVIDYCSYAQELVGGVGRNTAYDFRKALQDDLLNALEWLHVCRDVTKGLKALHAAGWLHCDLHCGNAMVCPNPPGSDVAWRGKIIDLGNALQISNPGPVTILDDEQQKKLYELAKQCAPEILEGRDTFTEKSDIYSLGNLFVDVASDANIPHGLRLLGEFCMRRIPDARPTLDAISGKLDDFISEMMQAEQQPSSPSPIAPSSSSPSPNLRCHLIAEMVQAEQQPSSPSPIPPSPSSPSPKMRCRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9B5</accession>
    <name>A0A914B9B5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072594.1">
        <property type="nucleotide sequence ID" value="XM_038216666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9B5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216666.1">
        <property type="protein sequence ID" value="XP_038072594.1"/>
        <property type="gene ID" value="LOC119741051"/>
    </dbReference>
    <dbReference type="GeneID" id="119741051"/>
    <dbReference type="OMA" id="NCIDIFA"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918697" evidence="7">
        <location>
            <begin position="17"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="133"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="40616" checksum="6A22AE4F4F062FD7" modified="2023-02-22" version="1">MHTCTLVLLLLVGVAAAGFAPLHKVNESIKGRYLIKFKDDLDVDTVVDDIQRRVQQQRLGHAKISYRYYRVVKGMAAELSEEALEYIRTLDEVECVSENPRSHATTPWGLDRIDQFNLPLDGSFSTSASYNEGAGVEIWVVDSGIRPTHNDFGNRASVEFDAYGGDGIDCHGHGTHCAGTTGGSYYGVAKRATIKGVKVLGSPPCSKSGTGDAMIAGLDYVAANAKRPALISMSVGFAGTWDYFDTVVRNVISGGIPVIVAAGNDNIDACTVSPSRISEAVTVGATDNTDSRAWYSNWGNCIDIFAPGSDIPSTYYTSDNAVYTMSGTSMACPHVSGMVALYLAENPNLTGAQVMNKLVNSATWGKLSNIGAGSPNLLAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBZ9</accession>
    <name>A0A914BBZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073564.1">
        <property type="nucleotide sequence ID" value="XM_038217636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217636.1">
        <property type="protein sequence ID" value="XP_038073564.1"/>
        <property type="gene ID" value="LOC119741754"/>
    </dbReference>
    <dbReference type="GeneID" id="119741754"/>
    <dbReference type="CTD" id="84684"/>
    <dbReference type="OMA" id="REHEKHK"/>
    <dbReference type="OrthoDB" id="8953942at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000488">
        <property type="entry name" value="Insulinoma-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF4">
        <property type="entry name" value="LD18634P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="457" mass="50789" checksum="286D6737541C6CB3" modified="2023-02-22" version="1">MPRGFLVKRNKKSGSVSYRSRCSDEDQDDAYIENDGMDGYTKPFNSPDSGYGHSPVTLLVKGSPAFRFDRESVYSPVSSPHLNTCSYPSPLTFSSSSPASLNTERDKTLWPFTVTPTTPPRRLPSGVPPPLRIKRPLSEETERKQHKAKKPKAARKLNFDEDNTSPVHGTIIRGDVPTDGGPDNDNGKGVNGACNGDKGVDNSLGGDFVCQLCKEQYPDPFSLAQHKCSRIVHVEYRCPECDKVFNCPANLASHRRWHKPRPNSRSTPNSPRILPASPAKPDGSKTFEVTHRTEQSDESLTLIKDDLTSTGSDSSRSTPSPGRATPNEEGQYECDQCGKKFRRPANLRKHMQHHGEEDTYPCQYCGQTFSSLTSRAKHVLTHAVGPKEITCDVCGGSYQNKMALEQHVRLHHSSEIYPCKYCSCNFTSSPGLTRHINKRHPSENRQVILLQQLPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFK7</accession>
    <name>A0A914BFK7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074645.1">
        <property type="nucleotide sequence ID" value="XM_038218717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218717.1">
        <property type="protein sequence ID" value="XP_038074645.1"/>
        <property type="gene ID" value="LOC119742603"/>
    </dbReference>
    <dbReference type="GeneID" id="119742603"/>
    <dbReference type="OMA" id="DIWHEYM"/>
    <dbReference type="OrthoDB" id="10424082at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="36925" checksum="9F64EE28377F8D77" modified="2023-02-22" version="1">MPVRHLECFCDQLVRATSNTFTYTHSATVRIESTLFRNFHLSRETRGLSTTQMFTCSVFFLHDQHVSLTNGHIMGSKHSAGSTSWIVYLVIVLFCSTSTEAQTAVGFEFREDYSRIAHDVDNFTSLLQTDIRKVFTFTNTTEVSSTEVTSSPHGKIRVNFTLTIDTTIDSKIRARSHLEDSLRMEQYEFVFEGDDYLVNGSTVWIMNSFPDIWHQYAPEIAIAVICGLAALAIFVASVQLICMNRKRPRRASYVPRPSLPVSYSGNSLGRTNGGFMMEELNGGNRVHTPKSSIGSTRFFYDRDTLYDKLIYGAYEVPPKHMYDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFX7</accession>
    <name>A0A914BFX7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074775.1">
        <property type="nucleotide sequence ID" value="XM_038218847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFX7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218847.1">
        <property type="protein sequence ID" value="XP_038074775.1"/>
        <property type="gene ID" value="LOC119742684"/>
    </dbReference>
    <dbReference type="GeneID" id="119742684"/>
    <dbReference type="OMA" id="HKTTEDT"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59132" checksum="2F1C39208380C982" modified="2023-02-22" version="1">MFYNLLSGLRCCFLGSLFPARMEASIFVGLHTLLLFAVTFLLVMAAVHRFRVRAKNLPPGPWGLPIVGSLLSLGANPHLTFLEMTKTYGNVFRVNLAGQRVVVVNGFEAVREALVKNASAFAGRPKMPLFHRLTEGQGIVSSDFGPIWREQRRFTLHTLRNFGFGKKSFEVKITEEINHMLAAFKEKGSEPFHADHILEISASNVVSSLNFGRRFDYKDPQFQLLVDMIYRFSEIGTNAAAANFFPFLINLPLPNIREMFNINDIITGFLTSIIGQHKETYNPVAQRDFIDAYLGEIARRQQECLQDEVTASFTERYLYHILSDLIFAGTETMSSTLRWAILYMIVFPDVQEKIQAELDSVIAKDQLPCIGDRKQLPYTEATLMEVQRMANITALPYPHKTTEDTELSGYSIPKDTPIYINLYSVHVDPTQWTEPEKFRPERFLDENRKVRNRPALMPFSAGRRACPGENLAKMELFLFFSSMLHAFKFSVAPENPQPSIEKNYGISLNPSPFKICTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHA8</accession>
    <name>A0A914BHA8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075653.1">
        <property type="nucleotide sequence ID" value="XM_038219725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219725.1">
        <property type="protein sequence ID" value="XP_038075653.1"/>
        <property type="gene ID" value="LOC119743321"/>
    </dbReference>
    <dbReference type="GeneID" id="119743321"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="573" mass="63632" checksum="BD5767DD97B1717E" modified="2023-02-22" version="1">MHYEDILKHIGPFGKYQKLILFACVLIKIPTAFHSIGQVFLAANTDHWCAVPASQMINCSQLQLAECQEEQKSYSIPYEIDDDGNKVYSSCERYVMNDEDVGRNMSLNSTDVISCDAGWKFAHSRYKSTINEDFSLVCDRQDLPAYAQSVWFAGLLVGSLVWGSVGDWIGRRKTFILTVILVTISSTVTSFVPNFTAYAAMRFFTAASGYGLNIMIYVLASEIVGPKSRVGATTVLFLAFAVGYMILSLLAFILTAWRHLQLAISLPFVLTFLAIIVFPESPRWLITKGRYKEATKIIEKIAKVNGTEAPEDLLDKLSEDSKEDKKQPSRIPVTQLDLIRTPNLRKKTLILWVDWFVANMVYYGLSLSTSALGVDDYLAAFVSGAIEIPSYLFCWYMMDRFGRRITLVAFYIFGGVFCLTTIFIPLGAARAAVAMFGKFAITAAFGHIYIYSLEIYPTIIRSIGMGTSSMMARVSGILCPIILILGKYWKPLPLCVFGGSAIIAGVLSLMLPETMGYSLPDTIQDGENFGKGRSFQLCVKGNDDGENESPTQAPIDYLPLSTKDETPKQPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJR9</accession>
    <name>A0A914BJR9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076061.1">
        <property type="nucleotide sequence ID" value="XM_038220133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220133.1">
        <property type="protein sequence ID" value="XP_038076061.1"/>
        <property type="gene ID" value="LOC119744272"/>
    </dbReference>
    <dbReference type="GeneID" id="119744272"/>
    <dbReference type="OMA" id="ANICQEN"/>
    <dbReference type="OrthoDB" id="10468766at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="718"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="908" mass="99561" checksum="BA11C72BE60E4C21" modified="2023-02-22" version="1">MSSNSSMSVGVCVKSSPLSTINCNTVNTAERSPTRRSTMKRRSQNAEIRTSFPDSVNAVGEGKENMEPFVEESDNEEDEEVFFGDITDMERFKMAKLRRKTQVFVANFRDVSSSGSGTDSLDESSSMHHSTSSQDSSVVISSSAEPESPASCNSSGETVAAMHQHPKLSHLERMAPSSTDSPSVLAHRAAAKIQTWFRLTRQAQEYQGVMREVERLEAKTDDFIQKIRREKERIKQCSTPEQGGRLDTASSSPMVIVPSHRLHLVETSPQQDNDVTTLQQSLNPAQLSTDSTANVIFNATNDSESIDTTTSGSASFSPVKLDESISAQSEVPKADSESNCSAAEQESYDTPDRHVQGTYQSKTNASVESSLYSTPSFVQSGSASQVTSVSSAGTLYHAAYSKVASDVKAHAVSEEHFVGTPLEFRKTEHNATNSPFLQVEKSSASYPQRTPLRQLHTSGTLSSFPKVTYEQIQSPTVFSSPRLFPVTVQAVQPQQSVSSAALFSPLKISDHTPVQDYQHSETMMSQSFSAKVTESQKPQKEIEKENHNLAFDFDTRQPTARNADSVRQDLDYQARPCLDSFTASSTPLAALPVSPNISVLRSAQKVAIVTPNSPLLPNTSRSDSKSHSTRCEMEYKTMPIADEGPRQQLSTAQEKGPSRHFFPSPLVMTRDTPETTTQSVPVTHPTGRPDPSNASRLEAAYGGRPGITTSPFTGARSCESARRKVELLEQKRAELARLRAEKAELKQTLKTENEMCFAMKQEVKAALHSNTSQTNIPVHLLSLGCQGISSLTLTDQELDIVTRLHTIRNSHHDNLQGVAASPMVTPIPHKGSLHLQWHSDLVTEVHCLSSPGHPVRVARPILANQDVCKARRVPAARTASPAQRVPTRQDKSRYPSGYTRTPREKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK06</accession>
    <name>A0A914BK06_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076141.1">
        <property type="nucleotide sequence ID" value="XM_038220213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK06"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220213.1">
        <property type="protein sequence ID" value="XP_038076141.1"/>
        <property type="gene ID" value="LOC119744340"/>
    </dbReference>
    <dbReference type="GeneID" id="119744340"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815391" evidence="2">
        <location>
            <begin position="26"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="318" mass="34701" checksum="7D85865E30520302" modified="2023-02-22" version="1">MAKSRWKRWSLELALVLVCCWTGDAVLRSRGQADSEDLPVVRPSIPDAGTVHGHRGYAGTLGVLTAAALVIPAGIISIIYLLYTHICKEGDEDADEMITGGKNEWSEISSNDVMLVNHLWSKTSGWPEEEEDEEMNALLLEGALGQDIQDGMEKLSLISRNGSSGDVTNDSGGFATMNGPDADSITPERETLVEAGKEPVEADRNGDLTTNTVEVHVTADDTYGPKATNHGMEESKRPVVAEQEPARFKQSVNMKVVNQVHVELRLTDLGEDSAPPAVNDGKEKYMSEMQLYLPGFERKTDERGRSFGVDINDNGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMN7</accession>
    <name>A0A914BMN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077006.1">
        <property type="nucleotide sequence ID" value="XM_038221078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221078.1">
        <property type="protein sequence ID" value="XP_038077006.1"/>
        <property type="gene ID" value="LOC119744886"/>
    </dbReference>
    <dbReference type="GeneID" id="119744886"/>
    <dbReference type="OrthoDB" id="8044756at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037180549" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="140"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="274" mass="28399" checksum="2D7E5DED8A09A1AC" modified="2023-02-22" version="1">MKICVAILSIALLLGNSVKLRASVTGPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPGGPMGPYGQPGSKGDVGEKGHKGEIGPMGERGAPGNTGSKGDYGIGLPGKVGPRGLPGFVGGTGETGVKGQKGETGETPDDSNQRVAFTVVRTSSSDTYTSHDTRLPFQQTETLLPGTSFDLGTGTFTCSLPGTYVFTFSVLKYSTSGSLEIHLVKNSYKVVTAYVVQNQREHVSGSAVLVLQRGDAVYMTMYGKAYGSRTYHHTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN42</accession>
    <name>A0A914BN42_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077707.1">
        <property type="nucleotide sequence ID" value="XM_038221779.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077708.1">
        <property type="nucleotide sequence ID" value="XM_038221780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077709.1">
        <property type="nucleotide sequence ID" value="XM_038221781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221779.1">
        <property type="protein sequence ID" value="XP_038077707.1"/>
        <property type="gene ID" value="LOC119745438"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221780.1">
        <property type="protein sequence ID" value="XP_038077708.1"/>
        <property type="gene ID" value="LOC119745438"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221781.1">
        <property type="protein sequence ID" value="XP_038077709.1"/>
        <property type="gene ID" value="LOC119745438"/>
    </dbReference>
    <dbReference type="GeneID" id="119745438"/>
    <dbReference type="OMA" id="HEKTTER"/>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="8">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="302" mass="32897" checksum="0ECA40D93811194A" modified="2023-02-22" version="1">MEDENNSTEQNNAAISAAEEKLQLITTQALPVSVVMSGMSSQPVAVSSVIQSNNTQPSVIQTTPLHTVQVQVTPVQDGEEQTTTTTVVADTEVDRKRRQDILSRRPSYRKILNDLSSTDTPGVARIEEETTEEDNTGTITLAGAAGLHGFPTVMTTGGATIQIANPAEMPSLQTLTMTNAGAPAGTIVQSIQTQDGTQQFFVPTASGDIQAYQIRPATSLPQGVVMASTNLQSSGHLHVHEEAGRKRELRLMKNREAAKECRRKKKEYIKCLENRVAVLENQNKTLIEELKSLKELYCHKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BND4</accession>
    <name>A0A914BND4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="18">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_038076987.1">
        <property type="nucleotide sequence ID" value="XM_038221059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BND4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221059.1">
        <property type="protein sequence ID" value="XP_038076987.1"/>
        <property type="gene ID" value="LOC119744873"/>
    </dbReference>
    <dbReference type="GeneID" id="119744873"/>
    <dbReference type="OMA" id="WRMFKNI"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000002">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="671" mass="76346" checksum="AB670D7A91E4A012" modified="2023-02-22" version="1">MASRQQPVLPLAQRYVNGVPVPEKRFSLRTSEKYFVYLIVLVFISLCYSALFLLPELRTRTTYVDAPEKMFQHNVDLPGGNKGGVVGHNPLDKTGEDIHGSEDKKKFRLQLRLDETLQRAKDALNGGMNMGKEIVQDSKKDGMGENAEKDDKLRVDVAKDEHKDVKEEVDQDKQKFLEKQKEEEAKRKEEQKEADLKKAEGNFEGVNLPDGEPDDEESKKRRDAIREMMLHAWNGYEKYAWGANELKPISHVGHSASIFGRSSVGATIIDGMDTLYIMGLKDKFLKARTYVAHDFHFSATTDLSVFEVNIRFVGGLLSAYALTGDEIFKTRAKEIADKLLPAFNTPTGIPYGLVNIKSGSGRNWGWASGGSSIIAEFGSLHLEFMYLSEITGEPVYRQKVDKIRDVLNSMTKPNGLYPNYLNPKTGKWGQQHVSLGALGDSFYEYLIKSYIQSGLKDERAKKMYFEAVEAIEKKMKQTSPGGLTYIGEWRANRIEKKMDHLSCFSGGMFGLGARYSNKKEHYLELGGQIAETCHQAYDNTATKLGPEAFRFEGRSEAVAMRQNEKYYILRPETIESYFVMWRLTHDQKYREWGWEAAEALNKHCRVDSGYSGIRDVYATKVGHDDVQQSFFLAETLKYLYLLFSNDDLIPLDQWVLNTEAHPFPVIKNWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPQ6</accession>
    <name>A0A914BPQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077477.1">
        <property type="nucleotide sequence ID" value="XM_038221549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221549.1">
        <property type="protein sequence ID" value="XP_038077477.1"/>
        <property type="gene ID" value="LOC119745295"/>
    </dbReference>
    <dbReference type="GeneID" id="119745295"/>
    <dbReference type="OMA" id="TKAPNDD"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036789022" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="306"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="633" mass="70849" checksum="12F086055F528BDF" modified="2023-02-22" version="1">MESSLRILCLVSFLTVFVNFCSCDSPEHGIFNVTLNERDRFNGVSKNLAEDTEIAITVDCNGKGKFAIEWVVRYTECNGLTMDNATDYISSLFDGTRDLPLHERMKFDAEDYIALQWSNASNKLSCETPHLLLQDESGPDSYTCYTAYDNKHCQYRGVWTPTTETPATASAAAAPAAAAPAAAPAAAPAAPAATKQKSPGDKGKASSEVKRRDTDGLDADKNPKPAATNPSGTPTPTPKPSATTKKANATLPKPLKGRVTTTNKRAGRYWVLVHLKPLETLDPTFKVTLTITMKSPSGFLSAYQAPLLVFYGVMCGAYSILTFIWLILLAMQWRDLLRIQFWIGGVMLLGLLEKAVFYAEYENINNYGMSVPGAIIMAELISCFKRALARMLVVIVCLGYGITRPRLGKDLHWVLGVGMLYFIMSSVEACLRVKGTDQNDMIAILPLSVLDAIICWWIFKSLVDTTRTLRLRRNMAKLWLYRHFTNTLIFCVVAAFVFLLWSMRVHRWTDCMKKWNELWLDDAYWHVLFCVILVVIVILFRPTANNQRYAYSPLTDREGDDESQEPMLNDAFEGMKMRNVVSNRNESQTSHKTDDDLKWVEDNIPAAVADAALGAFDDSEEELVTNLERSKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQN6</accession>
    <name>A0A914BQN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 33B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077802.1">
        <property type="nucleotide sequence ID" value="XM_038221874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221874.1">
        <property type="protein sequence ID" value="XP_038077802.1"/>
        <property type="gene ID" value="LOC119745498"/>
    </dbReference>
    <dbReference type="GeneID" id="119745498"/>
    <dbReference type="CTD" id="26276"/>
    <dbReference type="OMA" id="QVHIYMI"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.850:FF:000001">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69155" checksum="B3172F2855BE2810" modified="2023-02-22" version="1">MAATSGSPKFPDFSVLKQLSKEHLVHLLESIPEKKDLVIDPDLMRPLDRIAGAQLLKRHGVDKIFKLESNKLEISGDSRMYLARPSVKNVKNIANQIKGDQENGRRKKYKILFVPRKLYFCEMLLEQEGVYGAVELEDFKLDLIALDRDILSLESPGFFRDYFVEGEHSLLHTIATSIVNLQSLFGTIPHVYGLGRCAKMVWDLVNTLKSLQGEPRAPIRNEIGHLFLIDREADLVTPLCTQTTYEGLLDETFNIRSGYCEFGPEVTGTDKSMRLLLNCEDQIFEDIRDRHISHVFAYLSAQAKMVQTGYQKGRELQNIGDVKSFVQTELKDLKQQYKSLTIHIGACERILNLKTKQINFEEQLQTEHSLLEGINLKECYTYIEEQIDRQVPPDKILRLLCLLSLTQNGLPTKDYQTLETHFLQSHGHKHLLTFSNLRKLGMYTEQPSVEVTKMTAADVRTKLTDKALMKKTAFRMLCKKLNLIPKSGEVNLRNPEDMSYVFSGAFTPLTCKLVEQVLAKGGWAGLDDVTKLLPVPTFAEHKAQSVKGRGSNGHHQVAPSEKVVLVYFLGGCTYAETAALRLLGKMKGYQFIFATTAITNGAALIGSINDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT61</accession>
    <name>A0A914BT61_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079160.1">
        <property type="nucleotide sequence ID" value="XM_038223232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223232.1">
        <property type="protein sequence ID" value="XP_038079160.1"/>
        <property type="gene ID" value="LOC119746341"/>
    </dbReference>
    <dbReference type="GeneID" id="119746341"/>
    <dbReference type="CTD" id="84128"/>
    <dbReference type="OMA" id="WILNTRI"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="337"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="759"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="851" mass="95229" checksum="01E3C757118CD867" modified="2023-02-22" version="1">MAALSAGRVVVRGGADLVKNRPVFSSDSKYVFVASGYTVKVFNVASGDCVRQLRGHDGEVTGVVVNPQNKLQVFTSSTDGTINQWDYMDSVLLKTLYVRSPIHGLFAHPAIPDYLFATTFDEKSDKKSRLKLVKIAIPKMAGTCVDVQDKFLLGNVLAGDKGIAFGVGGEFIATVKGNTLKILFMEDLSLKKLSPDKTPLTCVACHPVDYCIAVGDEKGRISIWRNFHKKERRALEHWHSLRVEDLCYSPEGSVLYSVGHECTLVEWQHESLQKKFLPRQGAPINHVTCSPNSQQRALSLMTNAILIQSHQKTTQTVQGLVHTNFNRRREGYLPTGLVIDPHTRALVTNGMVGQLQFYQLEEDRLLFSLDITGENYISPADLGHPLMHTEVEKVTFDLRGEWMATVERRDDKQTSPEMRLKFWQFDKLKQSFVLNTVISEPHTGRISCLSFRPSSSSVSHDMYEPMAVTAGDDGKFKLWALANDDDSHSKNRSWGCDSVGFFREDMPRCACFSSDGSLLVVAFGHVVTIWDPDVNVLKKTLCHGTKDHLIEHMAFGHGSASHCLVSASSSVLNVWSLLTCSVIWRVNMKVSVLAADTESEFVAVFDKSGNLFVFHPLEPKLVYSKQDLPTPHIISAVFIPKTREDTSAARRSDLLPWETHSHLYFVTKCLMLATVTSQVDQQRANRADLEERLPPTPFAMLLNNQQRKVDKEGEGVRMQDLPASANMREMLQSPAHILPPVKSLCATFLQGLLNPGAKALQRRDEVDTDESDAESDKESDSEESDMETETAVRGHMTQSKDTGNSTDQSEHHVRSGDQYANEALSEADYRRLEKVSRSGLKWMRKVFQETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYK3</accession>
    <name>A0A913YYK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044643.1">
        <property type="nucleotide sequence ID" value="XM_038188715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188715.1">
        <property type="protein sequence ID" value="XP_038044643.1"/>
        <property type="gene ID" value="LOC119719308"/>
    </dbReference>
    <dbReference type="GeneID" id="119719308"/>
    <dbReference type="OrthoDB" id="1565622at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43878" checksum="49F7D8467CED1833" modified="2023-02-22" version="1">MSKMERRPESDHTVRLHGRSYDDDVASIVIDSGSSMTKAGFAGEDAPRVSFPTVVGRPRHKGVMVGMAQKDAYVGEEAQSKRGILTLTYPIEHGIVTNWDDMEKIWHHTFYKELRAAPEEHPVLLTEAPLNPRANREKTAEIMFEVFNVPALYVEIQSKLALYASGRTTGIVLNAGRGVTFAVPVYEGYALPHSVTRLDLGGDELTDYLMGMLSDRGYSFTTEAEREVVRDMKEKLCYVALDFEQEMASFSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFVGMEGDGIHEATCRSIDKTDSSIRHEMYGNILLAGSSTMFPGIADRMQKEVTALAPPTLKIKIIAPPERKYSAWIGGSILASLSTFQQMWISKQEYEESGPSIVHRCGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZF7</accession>
    <name>A0A913YZF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044782.1">
        <property type="nucleotide sequence ID" value="XM_038188854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188854.1">
        <property type="protein sequence ID" value="XP_038044782.1"/>
        <property type="gene ID" value="LOC119719412"/>
    </dbReference>
    <dbReference type="GeneID" id="119719412"/>
    <dbReference type="OMA" id="ILYHTPS"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="166"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="973" mass="108775" checksum="E0D60A91C82A41C3" modified="2023-02-22" version="1">MAAQSEAACQTDVPTMMQQEAQVPTPSATTDSPQRTGAIRKIGTVSGSNNPTIVGSNVVNFYSSASDGAGVLPQSRRPDQEPRVGDLNQEVGNKTRDILRKWYKTTRSYVQLNPGVPGDQRPIVGIYTKLRVRTKKGSVEEEYSDENVYSTEYDKIFQDWPETEFNRAILFGIGGVGKSTIFDKIAYDWVDETCEFLKRFKLVFLLKMCALSQESDLVASIFDQLLGETSGVTKIELHKFIQANSNKVLILLDGFDEMRTKTFDAASFGSILKALNRTAYRDCFICVATRPSHLETLMSKSLVQNPCTHIEVLGFTDEDVNEYIRKFYYKDPDSGNALIQHIAKSNTVHDFASNPMFLLLICLLWREKKQLPETTSRLFTEAVDNMFTRKGYSSENASKTVIAVGKTALSGFISADQNFSFQKDEFEQNALDLALKAGILTQERVIKNLKCHNNIQFMHKTIQEYCAGKYLQRVHLSSRGFVKRTAYKVVPLGKFQKQLRQLCQSVESIVSNEFLLRFCCGDNKKCMTDIVTLLERKFKEQNKPGCMYQKAVTQAISRQCFFESQSKKVPRCLTSNSLIPSDIEVDNNTDFRILIYLLEIICRSEFQVSQLACIETMKVSKVSSVSGLAFAMGYMENLRGLTLDCTLGKGELEKFLSSLKCNYLLTSLDIYHCHTLGGRAVVWAPHIKHLTSLEKLKVRRCELQSTDIEHIASAVGDMPKLTDLNLNSNNSLGECAAVWAKELPKMMHLNKLDLGNCDLTQSDIPHIASAVGNMPKLTDLDLRSNDSLGECAEMWANELPKMMHLTMLNLGNCDLTQSDIPHIASAVGNMPKLTDLDLGNNGSLGECAAVWAKELPKMMHLTMLNLSNCDLTQSDIPHIASAVGNMPRLTDLDLSNNGSLGECAVLWAKKLPKMMQLNKLNLSWCNLTQSDILYIALAVGSMPRLTELDLCFNLALDGWDKLQSFFSSLGVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZG5</accession>
    <name>A0A913YZG5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucocorticoid-induced transcript 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044968.1">
        <property type="nucleotide sequence ID" value="XM_038189040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZG5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189040.1">
        <property type="protein sequence ID" value="XP_038044968.1"/>
        <property type="gene ID" value="LOC119719566"/>
    </dbReference>
    <dbReference type="GeneID" id="119719566"/>
    <dbReference type="OMA" id="ISAHNYV"/>
    <dbReference type="OrthoDB" id="10037581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF8">
        <property type="entry name" value="GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49635" checksum="E24F561D833568DC" modified="2023-02-22" version="1">MSSQPPQRPRRNASPRAGPQPMRATLPVTLQVRQSSPTRSSNGRRSSPALASSPTQPWTTGENHHKVKHRRSPDHRASPERSPSSPGFRVEKPKAVRASPIRRTNSLDTIAVPYLSGYWPRSEAVTCPVSTTSSLSNSHEPNQKDQSTQTEEIDRKGSSHKRSSSWGSADNLKEKLRQQLRKQGSRQSTANTQRASPVHANHSTAATYTAPSSSPAAPTNQPLPRSSAIPVPNNSLKAPTPKIRGSVEGLNQEIERLVLQGVRREDDTDKRGVIIQTQEVTLDGRRAPPPVLASIDTGTQTPAENQDDGNISEENGSRGSGSRSHSVSPTFQMDGSPSRPSSRSSSTGNGEVKGEKGEASPDFHGGKYASSPSHNRSYQLTRDPPDGCEKVRSIEEPSRIPLFIEGDLEYCPDKKVSFKLKPSDSSAFCPLPNYPPGEFTKALQATVAATQTQNAACGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1F7</accession>
    <name>A0A913Z1F7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_038044514.1">
        <property type="nucleotide sequence ID" value="XM_038188586.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044515.1">
        <property type="nucleotide sequence ID" value="XM_038188587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1F7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188586.1">
        <property type="protein sequence ID" value="XP_038044514.1"/>
        <property type="gene ID" value="LOC119719216"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188587.1">
        <property type="protein sequence ID" value="XP_038044515.1"/>
        <property type="gene ID" value="LOC119719216"/>
    </dbReference>
    <dbReference type="GeneID" id="119719216"/>
    <dbReference type="OMA" id="LPKRRQC"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23433">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000096">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 13" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="451"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="579" mass="66079" checksum="00E54CCD1F73B127" modified="2023-02-22" version="1">MMPKRRQCKIIIATSLVWILIDFGLLLYYTAPCIGPGCAKEAAVDDQGPIQRMIEKANDWMQHRPEERKQIEVPRQFNSDGPGEMGKPVIIEPENKAESERLFRINEFNLMASDRISVNRSLPDVRPRGCANKVYPKNLPTTSVILVYHNEAWSTLLRNVHSIINRSPRDLLAEIILVDDASDQEHLGKKLEDYVAKLPVPVRITRMPERSGLILARMTGAGIAKGDVLTFLDSHCEVTEGWLEPLLGRIAADRKTSVCPVIDVISDENFGYQHGNDPQMGGFGWSLFFKWYPIPHRERLRRRGDNTEPVQSPTMAGGLFAIDKKYFEELGMYDPGFKIWGGENLELSFKLWMCGGKLEFVPCSHVGHVFRKKSPYHFPPGTNYVNKNNKRLAEVWLDEYKNFYYRISPVVAKTDAGDLSERHALREGLHCKSFKWYLENIYPESSWPVDYKSMGEIRNVQNNKCLDTMMKDSGHKVGLFGCHGQGGNQIWAMTRLQELRHDDVCLDVARGGPIMMLSCHSQGGNQQWAHNTETKELKHSNGLCLDLSDKSQDEPSMKPCNGHKSQQWDMTSWNWNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2S6</accession>
    <name>A0A913Z2S6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046129.1">
        <property type="nucleotide sequence ID" value="XM_038190201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2S6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190201.1">
        <property type="protein sequence ID" value="XP_038046129.1"/>
        <property type="gene ID" value="LOC119720513"/>
    </dbReference>
    <dbReference type="GeneID" id="119720513"/>
    <dbReference type="OMA" id="SSTHNEM"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11401">
        <property type="entry name" value="bHLHzip_Mad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF54">
        <property type="entry name" value="MAD-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22736" checksum="246F205584E3C459" modified="2023-02-22" version="1">MAAVAMTNITQLLQAAEFLERREREHGYASTMPYNPESSRRKLNKVKRLHSNSRSSHNELEKNRRAHLRNCLERLKEIVPLTTESARHTTLGLLTNAKDFIANLEREERKYQLHKDKLAREQRFLKRRLDQLSVGPGRHKIRQDSTGSSSLMSDDSEKDDVDVIGYNSDSDLSSSSEMTGSDGGLAVSTVKEIIIVEQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4F1</accession>
    <name>A0A913Z4F1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045871.1">
        <property type="nucleotide sequence ID" value="XM_038189943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4F1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189943.1">
        <property type="protein sequence ID" value="XP_038045871.1"/>
        <property type="gene ID" value="LOC119720302"/>
    </dbReference>
    <dbReference type="GeneID" id="119720302"/>
    <dbReference type="OMA" id="ENCNINT"/>
    <dbReference type="OrthoDB" id="9976543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="750"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="883" mass="101396" checksum="B2E9D093BA003047" modified="2023-02-22" version="1">MHYRSSYETTSFRTLTAYVTPAILYAHLTITKENCNINTATMSSAETFGHFLLPMTMNKGHIETKLADYVFKVRSRYLELKENRPERHALRNLLGMLAFRIGQFEEALGYLDKILSAGEDPENLNALANRKYMCEKLFRLPEARESERKILELTTEDGTEESKNRCRRLRARSLAEQAFAYSFELFGESVTVERYCKSVELYDQATQLAGNSICQEDREDWAIVYGMDCHKIYTKCKRDSSLRDQSTTWCEKAVNNFLLIIQESQDIRLLSESWRHLGELFKNPRHLPSIPKNMLRYVERPEDCFEEALEISKGDSRILARYAAHFKHKGNYSMAMLKVNESIMKDRSDFNNHAYFVRASIWLETYKNQLKNMKRRPLELPNPNLLENAESDLKIAHQQSDTPWHLHCMAEVLYHKAKDPNEQAKQGAKRKANLQLALTYCAKAVTCQDGQKQAQYHRLRGDCLCAMGEHQAALGCYKRALECEISVHYFLGSGNSLVIEFEHILKENTSLIEDSHFLDDMVYWLHKVANICLSIRWTLWNLQNLKQLPVQWKTFVKYCEDNGYESKIQTIELAAVDVTKRQRQSGTQRLYSFPLTEDRASPERSIRRHQSYPGTHSFDIEASVFAPDETAGVQTEIDQEKVVETLPGGKVAEGAVVSPGASAASEVPITDKIGKDVLTVPQHLSQVDLDGNEEHPIAPDTIHVTYSVNLKTGKTHHVATRPSPEEPPTEVVSKKHVRVAPERPLNHLERKYDFFVIYSSSASEWVQHHMLEELEGTGFKGCIKDRDFELGKPRLDNYSNSIEDSVCIIIVLTRDFETNKNDVRGMHMALDSDRLVIPVLREDRVMPPVLKSIEHLDATGAVDWPRLERCIEQQVKLEVLWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6V1</accession>
    <name>A0A913Z6V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038046731.1">
        <property type="nucleotide sequence ID" value="XM_038190803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190803.1">
        <property type="protein sequence ID" value="XP_038046731.1"/>
        <property type="gene ID" value="LOC119720936"/>
    </dbReference>
    <dbReference type="GeneID" id="119720936"/>
    <dbReference type="OMA" id="ESQACEY"/>
    <dbReference type="OrthoDB" id="10009406at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19695" checksum="031EA1C80BE0FA54" modified="2023-02-22" version="1">MKVVNWVVEKCSLLDQLFITLTKLRLNIGHEDIATRFNCSRPTVSNVFNTIISALYNILYVGMMENNIPSRSKNAMSMPSCFSKFPNCRIVLDCTEISVDNTEQLDAQCSLYSNYKGRTTLKSLIGVAPNGVITFASNLYGGSVSDKAITLDCGILDQLEEGDMILADKGFLIHDILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6X8</accession>
    <name>A0A913Z6X8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paraoxonase</fullName>
            <ecNumber evidence="7">3.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a phenyl acetate + H2O = a phenol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140310"/>
            <dbReference type="EC" id="3.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5 7">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.2" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038047563.1">
        <property type="nucleotide sequence ID" value="XM_038191635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6X8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191635.1">
        <property type="protein sequence ID" value="XP_038047563.1"/>
        <property type="gene ID" value="LOC119721555"/>
    </dbReference>
    <dbReference type="GeneID" id="119721555"/>
    <dbReference type="OMA" id="WEDENTG"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01785">
        <property type="entry name" value="PARAOXONASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="In form B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="37812" checksum="DC25E5F71A528080" modified="2023-02-22" version="1">MFLRRLMLGVHRHSFNHTPGPCRVVPGIDIGSEDITVTSSGLAFISSGLKYSPADWETESERQSRIFTFDFNHPERNVSEVSIKGESFDKEGVNYFGLSIWEDENTGKVTLFVVNRAKTKSSVELFDYGQETNTLVHKETVTSENIYSPNNVVAVSTRSFYVTNDSKYRSILEIFSPIPTGTVAYYDGKKARIVATGFTMANGINQSPDGKYVYVVGVFDGEISIFERNKDGSLRLLKKMDMHTTADNIDVDRATGDLWLGCHLQPYKAIFGGEHSHNRGTSQVLKVTFDKDLNADVREVLIDDGQLLASGSSVACTYGQQMLVGTVREKMLYCQLLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9J7</accession>
    <name>A0A913Z9J7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048453.1">
        <property type="nucleotide sequence ID" value="XM_038192525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9J7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192525.1">
        <property type="protein sequence ID" value="XP_038048453.1"/>
        <property type="gene ID" value="LOC119722417"/>
    </dbReference>
    <dbReference type="GeneID" id="119722417"/>
    <dbReference type="OMA" id="ANCDDPQ"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13322" checksum="1B4DA6A5317D6C5E" modified="2023-02-22" version="1">MAGEDLPVSKQGAATIDGIHTDVVCTAFKDRIFVAITQYEKLGTIVHVIPDSTPADTRQQSFTTKVLLGKDEPITHVMAKNLATKICEGPDSKPLLLAIALKEHSPSVLKSLQELVVQFRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAI7</accession>
    <name>A0A913ZAI7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048634.1">
        <property type="nucleotide sequence ID" value="XM_038192706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192706.1">
        <property type="protein sequence ID" value="XP_038048634.1"/>
        <property type="gene ID" value="LOC119722530"/>
    </dbReference>
    <dbReference type="GeneID" id="119722530"/>
    <dbReference type="OMA" id="CAEYMKT"/>
    <dbReference type="OrthoDB" id="10122539at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295746" evidence="3">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="36145" checksum="44555C0B26DE1CAF" modified="2023-02-22" version="1">MKYVGVFVLSLLGVIALTQGAPDCLDTFTAAQCAEYMKTGGAQIVLPLTEIPQLDAEKQAMLKYVLANVSDEYVIVDVEPKHVLITNIHLSADNGNRVAVDFFVANPTGSVVMPVSFRTNELYLVLKLNKEKIDDMLDYKVTVVEPDSANNLPIPTWALAIIVYAALVIVIGLIYYGTKDFRRQWSEAQDKKLRHAVLGDSDMELDPEAGEAGTGQGDSSEPNGPAKMYRDSQISFGVQVTKDDIEATLGITYATVESKDDAKKEDKCLDSPPPEKSHKPPDYHEATAPSASDSEASSSDTASKKSEASSAIEGAVNAAYEADEQDGEGDQTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBE4</accession>
    <name>A0A913ZBE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048351.1">
        <property type="nucleotide sequence ID" value="XM_038192423.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048352.1">
        <property type="nucleotide sequence ID" value="XM_038192424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192423.1">
        <property type="protein sequence ID" value="XP_038048351.1"/>
        <property type="gene ID" value="LOC119722355"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192424.1">
        <property type="protein sequence ID" value="XP_038048352.1"/>
        <property type="gene ID" value="LOC119722355"/>
    </dbReference>
    <dbReference type="GeneID" id="119722355"/>
    <dbReference type="OMA" id="HVFLEPF"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000453">
        <property type="entry name" value="GLIS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="327"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="798"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="967" mass="104997" checksum="529B5FB4624FD2A1" modified="2023-02-22" version="1">MVSTASRPGGAGPAGNMSMPCPPSTTGVRRVRLQSNNLSQSPTLSDISNIRNTPRIPSAMSSVSQAGQNQPPGGEHRQMFLEPSTVVPIKQEWSSSRMLPSLTPHSQGPGSQAGSDVGFPPPSSSLSHYASSFNSLSPFPVEISPSGSSFASPRHSARSFSARSRKRALSLSPLSSDDLNSIIRTSPTSLVAYIIGSRASSASISPSPGMQAGDYGHLSARNSSSPMSQGSSGNHPSYHIPRANTGDVSPPPYHPPKGGNGYRYNTYNNSSNMGPQQMEPLEQSSLPSIPQMASQFVVQPRNEVLQQDFQNYNPNAYSQNEQYKQEPIDSFPDSASTFSQSTSFSQQPSYPQTSANLSYPQLPSQPTNFSQAPTFSPPQPPAGYQMNPGYNHSQPGTPYQQQSMPSAQPVMANQVVQPSHMQPPPSYSQHFESHSRQASPAITTQVNSPGSSTAKSSLEMDSERVHICRWIDCSAVFEDQEDMVRHIEKVHIDQRKGEDFTCFWQACTRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCNKAFSRLENLKIHLRSHTGEKPYLCTHPGCTKAFSNSSDRAKHQRTHLDTKPYACQLPGCTKRYTDPSSLRKHVKAHTAKDQQARKKLRTRDEFGHPQDILTDCLTIQPLHPMSLADSPMELSDSGLGRSPHSSMAGTSSDMYPNMFSSAHSSRSGTATGASSYSNHPSPVHSMQGSPHNPTTHSVGNLDDARDSRVGMYPHPPMSAVSPTRRTFPPALLPRRIPQGLSSIPLKPRPPTSSPGINITPRIQIQLPAKPPPPPLIAPAPPLTLTLTAPAPPLTAPASQSDAPGRAMPPPISHMRLHATTRPSLTFQTLQPVPRPSVTNNNNNNYYKQLRHIPSPRGLYPIPTFEETLSPTPAQYEAIERVLSAHSSSDRGLTGDMPGSPGEFSILSAGRSLDDSPLLQMNAVDRCPSQLSAVYADGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD48</accession>
    <name>A0A913ZD48_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038049707.1">
        <property type="nucleotide sequence ID" value="XM_038193779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD48"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193779.1">
        <property type="protein sequence ID" value="XP_038049707.1"/>
        <property type="gene ID" value="LOC119723216"/>
    </dbReference>
    <dbReference type="GeneID" id="119723216"/>
    <dbReference type="OMA" id="CWEENEY"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF100">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038158121" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="78"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="17943" checksum="8E5CBADD83AC04A6" modified="2023-02-22" version="1">MKLLLVLLAATVALANSAAVQKSDISNLYQFGNLISCYGGAGFFDGLDYNGYGCYCGYGGKGTPLDDTDRCCLVHDNCYGRSTAEADCGSWDPYVIVYDYTETTVQAGNCVIECKKAADYSWYSTDPECREFICECDRAAAQCFAEKRPTYNQAYESYDKDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDB4</accession>
    <name>A0A913ZDB4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049767.1">
        <property type="nucleotide sequence ID" value="XM_038193839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193839.1">
        <property type="protein sequence ID" value="XP_038049767.1"/>
        <property type="gene ID" value="LOC119723285"/>
    </dbReference>
    <dbReference type="GeneID" id="119723285"/>
    <dbReference type="OMA" id="SLYDCEE"/>
    <dbReference type="OrthoDB" id="10028716at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037963282" description="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35373" checksum="2DBBD0FE2EAEA40D" modified="2023-02-22" version="1">MKLLNILVLLVLVGLCCGQYMERLSRRKRESCFPESTGTTPFIKEIFLGRCLELQTETAIPNACPQSPVNCTLLWDVFHDAIAYKDPCAIPLDAYREFIAAVPHQLPADKSMFWSGTSYIVHEYTEAANDLLTLEDTLLGYMVDGLQWCSSTDASSTGLNYQECPDFWQEGCAVASTAFYTATSSAIGRQATGVITVMLDATRTDGAYRNDSFFAKYEFPNMDPEKVTRGDIILVNRLGNPIVETCGTGSVAVLERLFTEKGIEWTCTDNDERVYHVQCSKDPTHTECITPADVTGSSATSRPSLIILAMILVCMVAELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE10</accession>
    <name>A0A913ZE10_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050017.1">
        <property type="nucleotide sequence ID" value="XM_038194089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE10"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194089.1">
        <property type="protein sequence ID" value="XP_038050017.1"/>
        <property type="gene ID" value="LOC119723435"/>
    </dbReference>
    <dbReference type="GeneID" id="119723435"/>
    <dbReference type="CTD" id="51122"/>
    <dbReference type="OMA" id="NGDHNTQ"/>
    <dbReference type="OrthoDB" id="10257479at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04750">
        <property type="entry name" value="Commd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037354">
        <property type="entry name" value="Commd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15857:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="23254" checksum="F22E59A90DC90CF1" modified="2023-02-22" version="1">MLLVLEDEHKEHLNFLVSVNVEVVQEFCRIAMEFIRKGINHKMYLIAAQKLKVDAETVQHGVEGLMYLMSESAKLMVTEIDFQDSILTLGFSEELKQELLRLYLDNRKEIRTIQSEMAMDLPHYHNLEWRLDVELASRSLHHQTSPSILLKLHTEESGSKTTQLLETDPSNLLHMTQCLESALAEVKSQHCRRIMRNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFI7</accession>
    <name>A0A913ZFI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="RefSeq" id="XP_038049735.1">
        <property type="nucleotide sequence ID" value="XM_038193807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193807.1">
        <property type="protein sequence ID" value="XP_038049735.1"/>
        <property type="gene ID" value="LOC119723242"/>
    </dbReference>
    <dbReference type="GeneID" id="119723242"/>
    <dbReference type="OMA" id="HYDCNEL"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="174"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="503" mass="53928" checksum="02639357E9C895D9" modified="2023-02-22" version="1">IVGIENKPKGKLCFNFPPTGRNYVVEAKTQAQTGATGKIVAVIGAVVDVQFDEGLPPILNALEVQGRPTRLVLEVAQHLGENTCRTIAMDGTEGLVRGDKCLDIGSPIRIPIGPETLGRIMNVIGEPIDERGPIVTASKAGIHQEAPEFVEMNLTQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIIELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIEGGIISLTDDTSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRGIAELGIYPAVDPLDSTSRMMDPNVVGEEHYSVARGVQKILQDYRSLQDIIAILGMDELTEDDKLTVSRARKITRFLSQPFSVAEVFTGSPGKLVPIADTILGFKQILNGDYDHLPEIAFYMVGDISEVIAKAEKLAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGC7</accession>
    <name>A0A913ZGC7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038050852.1">
        <property type="nucleotide sequence ID" value="XM_038194924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194924.1">
        <property type="protein sequence ID" value="XP_038050852.1"/>
        <property type="gene ID" value="LOC119724002"/>
    </dbReference>
    <dbReference type="GeneID" id="119724002"/>
    <dbReference type="OMA" id="HAPSLMM"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="10">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="231"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="410" mass="44734" checksum="8A146BAE706292D1" modified="2023-02-22" version="1">MEELQAFVTKSFESSESPKLGANVLTVKRNLPKFDTAAWLNAIGESTPTHRRPAKSSAGKARPTGGASDPSDPLTASAAVQAVPVAAKLPSFPTSLFGTADTDLARERLALFKRGTPQQLSKSTSAKRPKGTTEKRKLDRKSPWEDVGQVSEPQQITDVDLSPVDHDDDVDIDTDPDDDIPLHEDTDLSSADRGDHARLPARQPHDPKQTASGSPSPVPGVTATHPSKLKQRRSRTNFTVEQLGELEKLFDETHYPDAFMREELSRKLGLSEARVQVWFQNRRAKCRKQEHLGGKGTPIGANSNVDTCRVAPYLSMGSLRMPFDRVQEQLQLNLTSNVTAAPPVPRPLPSIFTHAPSLMMFPPPAYAFPLATLMSSMMRPGGSKTSSIADLRMKARQHAAALGLHSFLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHF4</accession>
    <name>A0A913ZHF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051217.1">
        <property type="nucleotide sequence ID" value="XM_038195289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195289.1">
        <property type="protein sequence ID" value="XP_038051217.1"/>
        <property type="gene ID" value="LOC119724301"/>
    </dbReference>
    <dbReference type="GeneID" id="119724301"/>
    <dbReference type="CTD" id="57213"/>
    <dbReference type="OMA" id="HMGNEVV"/>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="1">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="21266" checksum="F0E6098B18741ED6" modified="2023-02-22" version="1">MAACFCCFRCWPGGGFRTGHVPLKEIPTVTLDMSHMGGDVVIVKSGRRICGTGGALGNAPLVQDKAYFEMKLQSTGNWGFGIATRKCNLNVLPLGSKSESWMLRSDGTISHNGECLHKLEAEIAEGDIIGITYDHIELNFYKNGTPLNLPVTGIRGTVYPATYVDEGAILDVQFSEFYHTPPAGFDKVMFEQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK40</accession>
    <name>A0A913ZK40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051450.1">
        <property type="nucleotide sequence ID" value="XM_038195522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195522.1">
        <property type="protein sequence ID" value="XP_038051450.1"/>
        <property type="gene ID" value="LOC119724461"/>
    </dbReference>
    <dbReference type="GeneID" id="119724461"/>
    <dbReference type="OMA" id="WKEDPYS"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="79" mass="9518" checksum="4D6694059F9F9019" modified="2023-02-22" version="1">MSRLENGYQMTKPSNCDDEIYNLMLMCWQVDPAKWPSFNQLVTRLTSMADNPNEQTYMRMLPKTEEYMHMMIRPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKU2</accession>
    <name>A0A913ZKU2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051944.1">
        <property type="nucleotide sequence ID" value="XM_038196016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051945.1">
        <property type="nucleotide sequence ID" value="XM_038196017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196016.1">
        <property type="protein sequence ID" value="XP_038051944.1"/>
        <property type="gene ID" value="LOC119724799"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196017.1">
        <property type="protein sequence ID" value="XP_038051945.1"/>
        <property type="gene ID" value="LOC119724799"/>
    </dbReference>
    <dbReference type="GeneID" id="119724799"/>
    <dbReference type="OMA" id="RIGIDVC"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="30404" checksum="E645ACEF641F0CFC" modified="2023-02-22" version="1">MNSPPPPYNGHQQVTQQPQPMVAIQPNPSASDTTGSRSYWKGLQITGYMQVVLGVISVLLGFLAIVFKSFMYPIGIPIWSGICFYIITGIFGIASGRKQAKGLVITYMVLCIMTALAGCGVCIAHGIGILIQGFVGCPDFQHHPYLSNHDPYDFIYRVGCSSSFSSRAAINGLISVLGCIEMIVAIVGASFTCCVLCHSTTPTQVVTYTSTVPQQTVVQYAATPQQQYVQQPQYGNAMYPVQQVVVAPPQYQPQAQGQVQNQPTPQGQAQAPPPEKLPPADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLK8</accession>
    <name>A0A913ZLK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052683.1">
        <property type="nucleotide sequence ID" value="XM_038196755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196755.1">
        <property type="protein sequence ID" value="XP_038052683.1"/>
        <property type="gene ID" value="LOC119725357"/>
    </dbReference>
    <dbReference type="GeneID" id="119725357"/>
    <dbReference type="OMA" id="HGERNIQ"/>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="563" mass="61196" checksum="C73C508A58E9AAC9" modified="2023-02-22" version="1">MSSKSGKRGRSSSKSQPEPPGKPRLCRMVRGSSGYGFNLHSKQGQHGQYIRGIDAGSPAEAAKLRKGDRVIEVNGVNIERETHAQVVTRIKSGGDRTTLLVVDSELDQHNKKYALTVEAKTAEESQFIEEDAPAQQPEVEAEEEDAPKVNGDASSPEENGVVLTPVITAAEVTQEEAAPERIEEPVEEAVVSVEESVPVESVPNDVHATAVEAETEETARQPEEDAIEPEVIVAVAAADVESTPEYIREPSPERESSPEPERIIAPEIQVEEPQEPPQEPPSDPEPVPPVVLVPDPQTVQDPEPETQPEPTQTPEEPEPEPEPPLEPEPIKEPEPIKEPEPIKEPELEPEPPLEPEPIKEQEPEVSEEPETPVEKEPEPELAAPPAVIADEPSPEPELEPEPEREPTPEPEPEPEPEPEPVTEPTPEPTPEPEPEPEPVPEPEPVRAPTPEPVREPTPEPEPEPEPAKVPTPVPVVVDEPDHSKSKAPSPPEPEPQPEPKPVKPKATEKAKASKPERPAEAPQKGGLDLSDMAKARALAAGKKKKKAASSADWKSKYNAFQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLW2</accession>
    <name>A0A913ZLW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038052051.1">
        <property type="nucleotide sequence ID" value="XM_038196123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196123.1">
        <property type="protein sequence ID" value="XP_038052051.1"/>
        <property type="gene ID" value="LOC119724852"/>
    </dbReference>
    <dbReference type="GeneID" id="119724852"/>
    <dbReference type="OMA" id="FACPLSG"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="11">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="604" mass="67511" checksum="22683A2C4BC3DB18" modified="2023-02-22" version="1">MARFSPQLAAIFGGRFLADGQKLPGMSSRFSLGNRNILPGTTKQPRPETRRMAGLPGPLRWVHTTPCSSQCRRTDHEEKSQDMVPERKDDGLVSLEDLVFRILSNSKKKVALRDFFSVLASKGLRQTDPRLQESLEKIKEKFTQQYPDNIGDTLLDKLDFQECISSNIVLIGRALRNMFILPDFPLFAAQVDKLYEEIKMNTGGELATYIPQLARQNPDHWGISLCTIDGQRHSVGDTAVPFSLQSCSKAPIYAEVLTRHGSDHVHRFVGHEPSGRTFNDLCLNDSNKPHNPMNNSGAMLMLSLLNQSRNMADRFDDIMQRFKEMAGGEYIGFSNATFLSEKESGNRNYALCYLLQEYGCFPEGVNPMETLDLYFQVCSLEVTCESGSVIAATLANGGICPMTGKKVFDPAAVRDALTVMSSCGMYDYSGQFAFKVGMPAKSGVAGGIMVVVPNVMGFMLFSPPLDRFGNSVRGADFCEKIVSTYNFHNYDNLLHATKKQDPRRQYLQSKASRVVKLLFAAYNGDVSVLRQYLLQGEDMEQRDYDDRTALHVGAAQGHVEVVRFLLEKCKVDPSPKDRWDHTPLDDAERFGHTEVAELLRVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLW5</accession>
    <name>A0A913ZLW5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052324.1">
        <property type="nucleotide sequence ID" value="XM_038196396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLW5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196396.1">
        <property type="protein sequence ID" value="XP_038052324.1"/>
        <property type="gene ID" value="LOC119725030"/>
    </dbReference>
    <dbReference type="GeneID" id="119725030"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="219" mass="24885" checksum="0FC20A6D22BA832C" modified="2023-02-22" version="1">MLGAIFSGELDPSVRDATGAYVMDRDGPIFRHVLNFLRQGKLILPEDFKEWDLLASEADFFQIPDLVAAVSSRKDDLTRPPMAVADDPKKEFVEFVEQDNKNCKYRGSWETLERLPRKFRRVLEADPSFALSVQPQESRRSNEDMRTIVEGCGEISGYWGSYSVQCLPWHPNTSYKVTDPPNWMAVFQRASKLGFQLLSTSAMPGEKSSLFGRKVPPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZM96</accession>
    <name>A0A913ZM96_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038052872.1">
        <property type="nucleotide sequence ID" value="XM_038196944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZM96"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196944.1">
        <property type="protein sequence ID" value="XP_038052872.1"/>
        <property type="gene ID" value="LOC119725523"/>
    </dbReference>
    <dbReference type="GeneID" id="119725523"/>
    <dbReference type="CTD" id="3417"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="46295" checksum="924B6E7B69520796" modified="2023-02-22" version="1">MSKISGGTVVEAKGDEMTRIFWETIKEKLILPYVDLDIKSFDLSIQNRDETEDRVTVECAEAIKEHNVGIKCATITPDEKRVKEFNLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVVGWNKPIVIGRHAHADQYKATDFVIPGCGKVEIKFTPSDGTEVLNFTVHDFKDGGGVAMAMYNTDKSIRDFAHCSMKYALERKFTLYLSTKNTILKKYDGRFKDIFQEIYDSDYKSKFEAAGIWYEHRLIDDMVAYAMKSEGGFMWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVESEAAHGTVTRHYRLHEKGQETSTNSVASIFAWTRGLAHRAKLDGNAQLAKFVKDLEASCVDTIEAGFMTKDLAICVKGMNSVQRSDYLNTFEFIDKVAEFLGAKIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMR8</accession>
    <name>A0A913ZMR8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052351.1">
        <property type="nucleotide sequence ID" value="XM_038196423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMR8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196423.1">
        <property type="protein sequence ID" value="XP_038052351.1"/>
        <property type="gene ID" value="LOC119725060"/>
    </dbReference>
    <dbReference type="GeneID" id="119725060"/>
    <dbReference type="OMA" id="CHESCIA"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037610436" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="37559" checksum="42366E6720C0EA30" modified="2023-02-22" version="1">MKLLFAVFLGLLATVSSSPVKSLEQDFVEYSADLVEKINLMNTTWKAGANFARETAASLLERFSTPGLSLEKAPKAPIVKHGRAGALPTEFDARTQWPHCPSIGRVHDQGRCNGGYALSAAAAISDRHCITFPGLHWNFSAEDAVTCMTPTIGLDGCTGGYSSDTWRYWVQHGLVSGGGFNTSSGCRPYAYKPCDHYEKGSYGPCQARPSSAVCHESCIAGYPVHYTADKRKGATYYRTGTDETDIQREIMDNGPVNADMTLYEDFFTYRSGVYQHKTEQSMGFHAVKIIGWGVENNQKYWLCVNSWNSEWGDKGMFKILRGTNECRMESNVHGGKIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNI2</accession>
    <name>A0A913ZNI2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052934.1">
        <property type="nucleotide sequence ID" value="XM_038197006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNI2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197006.1">
        <property type="protein sequence ID" value="XP_038052934.1"/>
        <property type="gene ID" value="LOC119725558"/>
    </dbReference>
    <dbReference type="GeneID" id="119725558"/>
    <dbReference type="OMA" id="FMTATEQ"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57060" checksum="5F1712C946AA2ADD" modified="2023-02-22" version="1">MATREPAKSAGPRQNAPRSKIFLRENTMTLSEKIALYHHRADDSEDFRVAALRNRTCVANGGRTFVTEEAQEEAQAANTKPEGGNGRRNAKGGYIPTGRRSASDMSLAVCVSVTDSTHELMEAAEKGDTTAVRRVLKESSADMNFGHGGDYRTALLRACQYGQVDVVKELLEAGADAGIRTVKNRTLLHEACIGGHPKVLQLLLDRVEDIDAVDSEGQSACHAAGFQGELDCLQVLSEKGADTSLEDKNLKSPAHLAAERNHPRILSYLLSRGVDIETSDRLGRRPAHYAAIHGGLESLILFVQGNCDTLATDNAGCIPAHFAAKKDHLDCVRFLVKHGTDLGAKDGSGRTLAHMAALYGAMTCLHWLFEKGADASAKDNQGNTPAHLAATGGHAKCFNCCLQHNGPLDALNDRQDTPMDCARRSGHPQLMSRAGNNEVRCVHCADNYELVEWERSHQPSKVQKAIKEKKGGMFSSPLPRKPKAQEVQKPKVVRSKFTGSQGSSSSTEVLPKRDLAAKYFGRGEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNY9</accession>
    <name>A0A913ZNY9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053092.1">
        <property type="nucleotide sequence ID" value="XM_038197164.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053093.1">
        <property type="nucleotide sequence ID" value="XM_038197165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053094.1">
        <property type="nucleotide sequence ID" value="XM_038197166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197164.1">
        <property type="protein sequence ID" value="XP_038053092.1"/>
        <property type="gene ID" value="LOC119725668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197165.1">
        <property type="protein sequence ID" value="XP_038053093.1"/>
        <property type="gene ID" value="LOC119725668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197166.1">
        <property type="protein sequence ID" value="XP_038053094.1"/>
        <property type="gene ID" value="LOC119725668"/>
    </dbReference>
    <dbReference type="GeneID" id="119725668"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12476">
        <property type="entry name" value="RRM1_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="173"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="247" mass="27805" checksum="D40E6CC7904CF71E" modified="2023-02-22" version="1">MNVPPNQTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIVALKTLKMRGQAFVVFKDINSATNALRSMQGFPFYEKPMRIQYGKSQSDAVAKLQGTFVPREKRPEKRKPDPAPVQTKKSKKQEAAKQNALAAAMSQGPPPMMGQMPPNMMGQPPPMQMQQPPAMPLPDQPNAILFLTNLPEETNEMMLKMLFTQFQGFKEVRLVPGRHDIAFVEFENETQSGIAKEALQGFKITPTAAMKISYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP29</accession>
    <name>A0A913ZP29_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <location evidence="10">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053548.1">
        <property type="nucleotide sequence ID" value="XM_038197620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP29"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197620.1">
        <property type="protein sequence ID" value="XP_038053548.1"/>
        <property type="gene ID" value="LOC119725999"/>
    </dbReference>
    <dbReference type="GeneID" id="119725999"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="261" mass="28604" checksum="62252FA1B89202EA" modified="2023-02-22" version="1">MYLIFSSDTVFTYPGFSLRVEQVSPDQVSCNAGQTPCDYKDFICVNENSEGVCPDLECDSDAVTFLDDAVIVKSPGYPQPYPAGLYCRWDVPSRGLAPATLFRVLDFSTEAGEDVVQVSGLTFPGGEPADYTLAGTTTKIRAVVFNATTSVTVRFQTDFNIQLTGFHFNLINVNFTEWESDWCITDKQTGFICEGLCLVASAKCDGFLDCLNGEDENECAEVYCPSSYHCSQTKTCIVSEQLCDGEIHCEHGDDEVECGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQM5</accession>
    <name>A0A913ZQM5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053435.1">
        <property type="nucleotide sequence ID" value="XM_038197507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197507.1">
        <property type="protein sequence ID" value="XP_038053435.1"/>
        <property type="gene ID" value="LOC119725904"/>
    </dbReference>
    <dbReference type="GeneID" id="119725904"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="698" mass="77357" checksum="42E2AD92FB0E05D5" modified="2023-02-22" version="1">MSSQTNCDHCGGPYQKRVGGSSYLRYRVGLMVDQESAEVLFPLVNATAGFVCQKCRSFAMSKCRKVKGLAISKCRKVGRRTRAAYRLPPSAIARWRSGLPLEEDQEQGTEACAPLDSGSPMEAVGSLPPTNNSDEANVMPHSLPAQPLLYKRGKKPTYKVSTKRRTLAAIVADSPPPRKPRALKRLNKNIEQEHDYAKMVASVRESDNLKSKLATQKECANPFGSGSTMVAVGSLPPTNSSDEVNVMPHSLPAQPLPYKIPRRKAAHKKDAINSARKSNYRETLEHLWCLKQGRQAIIEFVKHKLKEELRSVQGTRKLSTLHKSATMENVQEFRWSNVVQEAKSVMPFTMVTLKGLLPSLSSVKRKKRKGPRTERKKLTTREARAVWNLKAGNILAILLFMWRPDIYNLWQSVLGVEMWHQGATQKLITIFHRLGLCQAVVTVRSKVNQICTLYDRELMEKAEVANVPDATVMNVPDATVMNVPDATVMNVPDATIMNIPDATFINVPDATNMNVPDAPVMNVPDAMQQPPDTRLSIKGILTSVSRLKLGNGRKHKTLQICADQHSKDKIVVILWENAATQDMPGLNSAVTVTNVATKMCSNRMTFNSTEETHVKPDDQCTTKDIAVTSLAEERCNILLLTEDNEVLYVAPSIFSSFSNTVLEQVVLPFSATVTFNAATNVISDMQHIPCSASVMEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR23</accession>
    <name>A0A913ZR23_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053824.1">
        <property type="nucleotide sequence ID" value="XM_038197896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197896.1">
        <property type="protein sequence ID" value="XP_038053824.1"/>
        <property type="gene ID" value="LOC119726266"/>
    </dbReference>
    <dbReference type="GeneID" id="119726266"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986692" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="129" mass="14270" checksum="F05E1DA966A1073A" modified="2023-02-22" version="1">MAPPFCFYLVAALMALSMSSPPTVRASSSTRRYYSCTDLAGAKLQVKLEVLRANEEAIVSLSNEYLNTSLPDSPWDLRLLRAFKRLKQRRNRHDDIGALVANITVDLNEQTQTLVQACNGNGLLLNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTV6</accession>
    <name>A0A913ZTV6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055173.1">
        <property type="nucleotide sequence ID" value="XM_038199245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199245.1">
        <property type="protein sequence ID" value="XP_038055173.1"/>
        <property type="gene ID" value="LOC119727376"/>
    </dbReference>
    <dbReference type="GeneID" id="119727376"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="17440" checksum="9B1EB6C58CAC4941" modified="2023-02-22" version="1">MTAPTAPRTDEYPPSNPPEKIITSQPAADDTYPPEPSPYPPDARSYPAAHVPYPPEPSPCPPEPISYPPPHRPPNPKPQATAASHVRVSVDDQGGRAAYTHQSTAATRQPQPQPTTITVKERRRRRGSGASDAVECCLLMAACSGMCEDCDCDDCDCDCDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW37</accession>
    <name>A0A913ZW37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055276.1">
        <property type="nucleotide sequence ID" value="XM_038199348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199348.1">
        <property type="protein sequence ID" value="XP_038055276.1"/>
        <property type="gene ID" value="LOC119727465"/>
    </dbReference>
    <dbReference type="GeneID" id="119727465"/>
    <dbReference type="OMA" id="NDISCDP"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037241096" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18564" checksum="9AE4DE554023B1DD" modified="2023-02-22" version="1">MMLPKRLIIGLISLCLMIRCTGGNERCGASIGGACPPAWSQWGDKCYKKLSENLPWAEAIQECIKMGSVLVMPQSQEETDFLQKNVYLWFWINCNDLQVEGTWVCQDGTTDVEYRNWRVEPAEPNNYGGGEDCAVVRRSGDWNDVECDSQIPTICQRPAPQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYF6</accession>
    <name>A0A913ZYF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056673.1">
        <property type="nucleotide sequence ID" value="XM_038200745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200745.1">
        <property type="protein sequence ID" value="XP_038056673.1"/>
        <property type="gene ID" value="LOC119728487"/>
    </dbReference>
    <dbReference type="GeneID" id="119728487"/>
    <dbReference type="OMA" id="KHATYTT"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037931875" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="170"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="436" mass="47255" checksum="E350BCA3DB6B45BC" modified="2023-02-22" version="1">MALSTRTVSCLQLLLLLPVITWMQSHGVGAIRAVTRPINTTGVVGQDAEFSCSVADKSANEVLTWRLQWDDTASPQSVHLSAEHNATMLEFDESAKHATYTTRYSVNGPIHTTVLHIANIQPSDAGSVACMYQITVSGSVIYYTIPEYTPVRLTVWIPPTPTCSFTNLDPNATAYGSPTIGATVELTCADTVGVPTPELTWRADERNPNTVNRSVYYHELQAEDNGRWFECQAISPASQTPVICSVRPMAVPPTAKVTPDVLNIIEGGNIEFTCTGSGLPEISSYQWFLDGSPTHAVNSQIYPSIKVTNTATGSVLTLEKISKLGQTVVSCEVMLSAGLTGRASGLVVISKQQVTVTPAARQQAHSEQQLGTAPSVFAIPLAFLFLLLILMVALLVWHRQLRHDSDTQKLSSDTTVNGVAPKQAKRSWKVYRVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A049</accession>
    <name>A0A914A049_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056965.1">
        <property type="nucleotide sequence ID" value="XM_038201037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A049"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201037.1">
        <property type="protein sequence ID" value="XP_038056965.1"/>
        <property type="gene ID" value="LOC119728705"/>
    </dbReference>
    <dbReference type="GeneID" id="119728705"/>
    <dbReference type="OMA" id="CLNIPWM"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="357" mass="39343" checksum="E165F34271ABFAB6" modified="2023-02-22" version="1">MELSTTAGVLSTGTSSPEMSTPGIISILTPIQRVILTSIMIFICIVGVLGNIIVISAVILSKKLRCVTNIFVVSLAVADLMTCLNIPWMAVATLSEAGWILPDWICTACGFVLMVCIGSSIYTLACVATIRSVVITGLPGRCRTLYTPPKICAILILIWTVPLAVATIPLVSNFGKLGYDFKYSSCTWDTSNPNSGNFSKLISGVFYPLPFIIITYSYFKIYRHVRRHSRAVAPILSISSSVAVRPSENRPNATGENIAMNPNNNSRDHRTGNSFRERLNKRQVDVTKNMFYIVCAFVLCISPFGFCLMYDASDPFVPYAGMFLFGNSCINPFIYATKHPDFKKVIRLMLTCKFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A150</accession>
    <name>A0A914A150_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057557.1">
        <property type="nucleotide sequence ID" value="XM_038201629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A150"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201629.1">
        <property type="protein sequence ID" value="XP_038057557.1"/>
        <property type="gene ID" value="LOC119729115"/>
    </dbReference>
    <dbReference type="GeneID" id="119729115"/>
    <dbReference type="CTD" id="54802"/>
    <dbReference type="OMA" id="TAENWGC"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.890">
        <property type="entry name" value="Crystal structure of tRNA isopentenylpyrophosphate transferase (bh2366) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="628" mass="70263" checksum="35E4CA145F8F9E3A" modified="2023-02-22" version="1">MAAPMTSVFRRLPVVVVLGATGTGKSKLAIQIGKRLGGEIISADSMQVYKGLDIITNKVTAQEQQACPHHLIDFLNPLSRYTVVDFRNKALPVIEGLLKEGRVPVIVGGTNYYIEALLWKVLLDTEHSKMEDLLLEARGDPITLHIRKNRKHSDMNHATNKEQDQNPVAASSSGIISDPSAAENTTRTSDFDDLDDSNTSCGSTGKGSNPDLSSSGIGKGKPDTAPGLELSKPEERIRTETETPRRQAAIAHCSQQVTGMDWQSFDKTGKESSPKESSQPDRGLDLYDATNEFVNALDTSQDNDVLENEESITIKVEGTATEDLYKILAEVDPCRAETLHPNNRRKIIRSLQVYEQLGRTHSEVLSGQMEEDGGGPLGGPLRFEDVCILWLQCDRDVLDRRLDERVDDMLCRGLLKELADFHHEYNRKRVESQADSETLYTQGIFQSIGFKEFHPYLILPEDDRETEGAQSLLKEGIEKLKIATRQYARRQTRWIKNRFVRRPGSNVPPVYAVDSTDPASWHEKVLQPALDILDAILEGKEPPVAPLVHEGGSPSDEASARHVCDICEGRVFVGKQQWLGHLKSRRHYKKSRKLRLASLMKSYEEQKTSSTETTNTQRQDTNQDVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1E0</accession>
    <name>A0A914A1E0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057439.1">
        <property type="nucleotide sequence ID" value="XM_038201511.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057440.1">
        <property type="nucleotide sequence ID" value="XM_038201512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1E0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201511.1">
        <property type="protein sequence ID" value="XP_038057439.1"/>
        <property type="gene ID" value="LOC119729026"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201512.1">
        <property type="protein sequence ID" value="XP_038057440.1"/>
        <property type="gene ID" value="LOC119729026"/>
    </dbReference>
    <dbReference type="GeneID" id="119729026"/>
    <dbReference type="OMA" id="FRETSAX"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54324" checksum="08A66EA75965C453" modified="2023-02-22" version="1">MKERSRSRWSFASWRPRSRKKAREAREAALANKSSTDDIQVSYSSDNATPAVKGTMTPPVERKSKKSTIPRFFKPWKWKRKKKAEPGKEPIQAFGNEVPDSSTQPHSPTQEVPTPADTDVTATNPEAANSFDTSTGQDYVPTSAEMSDQTAAGSTEVTKVEINNADPDLAPVPGEPVPSLVTPPAPTSPEDVAPPLPEKTGRVSPAVPPKKNRSPAVPPKRGVRMGNVHGAGSPAVNHTGRSVGFDAGQQAPRGVGFGSHVQNIPDTDGDAPDPSAVAGQCNGDINHAEDSDEDSLSDYDNKENSREEDSESDEDCNTSLVARVKRNDSLAFHLRNRPTREVLQERNILPQKSNDEMKQIMNAIGSKLVRRLSQRPTQEELEQRNIYKAEATHRTDKDLMEEKRRNLVRKLSFRPTVEELRQRNIIKFNEYVEVMEAFDYDRKAEKPWTKLTPQDKASIRKELNDFKSEEMSVHEESRKYTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1N5</accession>
    <name>A0A914A1N5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057550.1">
        <property type="nucleotide sequence ID" value="XM_038201622.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201622.1">
        <property type="protein sequence ID" value="XP_038057550.1"/>
        <property type="gene ID" value="LOC119729104"/>
    </dbReference>
    <dbReference type="GeneID" id="119729104"/>
    <dbReference type="CTD" id="9439"/>
    <dbReference type="OMA" id="QKHQKQR"/>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1372" mass="155912" checksum="0DCAF8FDE4745DAB" modified="2023-02-22" version="1">MSASTLDSQLQEILNDALRTTSIEEAFCGYILHSPEDDRNKVFCCIDSFNRFWKSLSPESHDLVLESYVAYFHRQKSHPRIKLLCDMLLTAAEKASIPARSLCEALLSSPSLDYKSSELWCKTFQMVDRIIVSVDYKGCRDLLKVILEKIELIPISVNVSASKQLDVAVKVLAKILDRNACLLPSYFAVNELKKLFPDDKPNTHWAVGQLVTNFIDTFRPTARMVSITGRPSLLPVVGHFNATHNSWKLDPVSLTFPLKGLLPYDKEQTQRQTNLLRYVLEQPYSRDMVRTILGLNIQHKQRCLVLEEMLVDLVVVAMERTEQTDGTFELGSPTDALWQHLSSQLIFFVLFNFASFPHMVMSLNKKLSNRSLTKGRDHLSWVLLQYISGSIKKNPLSDFFPILKLFDIFFPEKEPLPVPDVSHPQCTHRLAMACIWIHLSRKAQSDKVSLQRPAPPSLKLHLEFLQQSYNCSNLPLTDYRIAMLCNAYSTSTDMFSWPMGVLVDSIYSSGQTSVPMPGPSMCVASGPTAPLSMSLLDSLTVHAKMSLIHHIVGKNIIPAIHHKQSSMALSPALVETYSRLLVYMEIESLGIKGFITKVLPTVCEASAWGMLHTLLELFSFRLQHIQPQYIVQLLCNLHSLSKIPLANQNQLYQCIESTALRIITGLGSADVQPQLSRFLTEPNNLLSADSEELNRALVLTLARAMHVTGSETLSGSWCKDILTTLFTNTPHNWASHTLKCFPTALQEFFEAHPAPQEDRSLLKKTVEDEHRKWKAMTNEAEILNRFAVQGTQPGGPARGASQGNQHLFLCLIWKMLLENEPNHINPVAVKVIERIGPRALSSHIRTFADFLVFEFSTSAGGQHVNKCVETLNDMVWKLNIVSLDRLILNLALRNHEGSEAQVCFFIIQLLLLKPVEFRNRVNDFVKENSPEHWLQSDWHTKHMSYHRKYPEMYYYEGMLELTGATMSTPCQNLPVYFSNVCLRFIPVFDILIHRFLELPPASKSLEVLLDHLGGLYKFHDHPVTYLFNTLHYYEKKLRDRPQLKRKLVGAIIMAQKSVKPAGWCLTPQYLEYINKPGEEVAWEPDHDYYCKLIGRLVDTVSGKTQPPFQNMDWRFNEFPNLAAHALHVTCVELMALPGQGKFVGNALLEVIFKNPSILPRDDVMSWINTIALVLTSLPSCYCDVIQDRILEVLNSDLLLGKSVTPGAGILGNAFAVFDFRGTHSSHTEMMCAYVLAMTHAVWHHSNIGQLTPLQQFIRDQVKPVVKSEEQYLFVCHMVGPFLQRFHEERTRLLFEITKNLYDMLLVVDQHCSQIVHMDVICDFLYHIKYMFAGDGIKADTDRVIKGLRPAWQLRLRFISRGVDPNAVPPVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2K5</accession>
    <name>A0A914A2K5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057834.1">
        <property type="nucleotide sequence ID" value="XM_038201906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201906.1">
        <property type="protein sequence ID" value="XP_038057834.1"/>
        <property type="gene ID" value="LOC119729294"/>
    </dbReference>
    <dbReference type="GeneID" id="119729294"/>
    <dbReference type="OMA" id="MTIYMAC"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098660">
        <property type="term" value="P:inorganic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="72161" checksum="A109E003DA96578A" modified="2023-02-22" version="1">MVGEENRVFQVWDYVVFGLMLAISVFIGLYYGCTGGKQKTTSEFLLADRSMNPIPVAMSLVASFISAITVLGTPAETYIYGTMFWWFGLAYIGTGIAVTRLFLPVFYRLGVTSANEYLEKRFNKVVRVAGTLTYFIQMVLYLGIVIYAPALAFNAVTGINLWGCVVAIGVACTFYTTVGGMKAVLWTDVFQMCVMMAGFLAIIIEGSLRLGGFQQVWKIAEEGERIDFWHFSPDPSIRHSFWSIVVGGCFTWTATYGVNQSQVQRYLTVGNVKKSKISLYLATVGMVIVVSCACSAGVVMYAYFATMRCDPYTGLADQVKQTDQLIPFFVMELFGGLPGLPGLFTSSVFSAALSTVSSGLNSLAAVTAEDLVRPCFKKMEEERYTLVTKGIAMGFGLLSMLVAYIVSLLNKGILQLALSLFGMTGGPLMGVFSLGMFFPWANSKGAFTGLIVGLAMAFWVGIGAQIYPPDVYKPPLLVDGCFSPNVSTTSTYDATGFTDMAHLTTLLPTEEPAKPRIAALYTLSYSWYSCTFWLITVFVGLLVSFMTGANKPRDNDPMLKQHIADACYCCLPEFIKRPMRCGDDKLDYYEDDDVKDKDASLYVKEVEAKRGYDFQISESNGVGALSNMKYIPDVRDAEENVYDNPMELEHPVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3N1</accession>
    <name>A0A914A3N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase RNF10</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING finger protein 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNF10 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038057986.1">
        <property type="nucleotide sequence ID" value="XM_038202058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202058.1">
        <property type="protein sequence ID" value="XP_038057986.1"/>
        <property type="gene ID" value="LOC119729487"/>
    </dbReference>
    <dbReference type="GeneID" id="119729487"/>
    <dbReference type="CTD" id="9921"/>
    <dbReference type="OMA" id="PRWKKCP"/>
    <dbReference type="OrthoDB" id="10064108at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000112">
        <property type="entry name" value="RING finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="451"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="741"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="812"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="853" mass="94486" checksum="9F70A894CC1B878F" modified="2023-02-22" version="1">MSEPKEMEKNIALNRSACGVSKIPSEPKKDNGRGNGNGQSFHKKRESSLSKAGPDAGVQRKSNPQRSRGFTDKRPRSSKDGSWTGRRDEVTKSQRAEFGSALSGGPKKMNLNHLINFTMAPRESSMDNRGPGGWRGRNKWAHRYPKYNKEQFLQANCQFVVKAANDYTLQCVDSDKLVEWDLIEQVRILSPEVPSCPICLYPPTAAKITRCGHIYCWTCMLHYLELGEKTWRKCPICYEAVHQKDLKSVVAKETHGYSRGDEITFRLMKREKGSVITQPHSTREYGKLFTIEDDPTVTCMVKLLLASPEQVREKIIEPERAALEAQLQERNGELEDSFTEAALRMIKEREESIYKVHKIEALASHIVGLNLKDDTERQDVDEPVPMMSPSCKNYKHYSSAFSDEELDLAEDHDPNRQSQGFTVEEPFEDIAVSPAPKQDSGKDEAINAAGEAVARHQSPGLIAEEMGVTEGGSEEDTEKVGEEHYTSASSSPEDQARATGGSANGKDHVYYFYQAEDGQHLYLHSLNVRCLIREHGSFAQCPERITAKIVEVEHMSMNEALRRRLRYLFHLPLTCDFGICELEFKPPLVSKATLQYFAGDFQQRKKARERKVRNEKKQERKMQLKENKRNGKYVPPKFSLQSSIQFPSFGVDSVPGDVSYVISETSSSVTSLDSPASSSVGSPTSLSQEETAYGSLAQASGHCGLGSDSTGGPSPVIGSWASAASAEEHTASCPSFAQMLREGKTRAETSNWPKMEKAGGARSLTDKPPGEIRKASGPGPDGSDDSSNEDYVPIPQYKDAFSDAIQAALDKAAIQAASHKTDDDVTSSPGSSKRGKKGKKKQLLFSTAGPRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A411</accession>
    <name>A0A914A411_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038058304.1">
        <property type="nucleotide sequence ID" value="XM_038202376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A411"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202376.1">
        <property type="protein sequence ID" value="XP_038058304.1"/>
        <property type="gene ID" value="LOC119729693"/>
    </dbReference>
    <dbReference type="GeneID" id="119729693"/>
    <dbReference type="OMA" id="DPDCGMR"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="39491" checksum="E0220581D0F4EBFC" modified="2023-02-22" version="1">MPLKTTVIGSYPKPDYLAVPSWFETNDHTDMLSRHGKFLSEKKATPEFSDQFERAVKEVLSEQAELGIDVVTDGELDRESYVWYLCRNMKGFSFENLEVCTYRDGACTSVLPQVVGQIGAGRACDAIIKQWTFAQANSSMPVKATIPGPLTIMDSTKNKFYSDEKQLSRDLVVVINKIFTGLVEAGCRHIQLDEPLFVREVERCLDFGIDHASRCIEGLGNEVTKTIHLCCGYPNYLDQTDYHKADPQGYFHIADKIDQAGFDEISIEDTHRRNDLSLLAHFKRSKVILGSVTIASSKVEPVTEIRDRLKSALNYIPSDRLGVAPDCGLGFLPREIMRQKLKNMAEAAKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A500</accession>
    <name>A0A914A500_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dyp-type peroxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038058476.1">
        <property type="nucleotide sequence ID" value="XM_038202548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A500"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202548.1">
        <property type="protein sequence ID" value="XP_038058476.1"/>
        <property type="gene ID" value="LOC119729800"/>
    </dbReference>
    <dbReference type="GeneID" id="119729800"/>
    <dbReference type="OMA" id="RACKCIF"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="463" mass="52788" checksum="09195A75ACCDED48" modified="2023-02-22" version="1">MEHRAVKRQKKRHPETRSLADSAHAKESTYLLAQPGIFYTRPKYGCMVVVNLNDKTETGKTGVFNAIQAVQQKCDLLQGRNGYVVSFDPALWKTWSPNDDIEDRPQGNYMLSSSRKFVNTGGDVSFFLKSDTEDVVPKLFQEVENNLHGLASLDVTHTRVYNDRAINGKFRDGVANPVDKTTVERFILTPQTTTPRSGGGSYFYTQKFRMNFSIFDEMTIRQQENVIGRKVTDEIVIGADSRSHIRRARLAEASIHLKILRGSMPYGRDDTGQEMGQEGIYFNAFADHFQLFLDLMQSLVGDDPDFTQDKLISMTQGIEGSFWYTPSLYQLGFTDEPDVGQAPTLDFLPLWDVRSTNDYMFYNWREYLHRMSFGLYAPGDPPTHRVIKLLSVIFSEWSDQWYEKPHTARIPHLSNYLTAAEKPYLEESAAIRKGMAIKKTLGTLIPKTDYGTKTTSSAYTRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A620</accession>
    <name>A0A914A620_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058851.1">
        <property type="nucleotide sequence ID" value="XM_038202923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A620"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202923.1">
        <property type="protein sequence ID" value="XP_038058851.1"/>
        <property type="gene ID" value="LOC119730147"/>
    </dbReference>
    <dbReference type="GeneID" id="119730147"/>
    <dbReference type="OMA" id="WAISVNA"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="413" mass="45097" checksum="8A9CB043D1066ABA" modified="2023-02-22" version="1">MKGLAVLLPTLQGQADTYTWVIGWMIVIMEVTADLTGPIASPLERRFGIRACLMVSGVMITVAFIVSAASSSVLVMAVVLAALAGPGIGLSHVLSRELIGRCFQSGGTSTAFSISQTGTPAAYIAIPWLSQLFLDTYGYRGTLLLLGAIFFHLTACGALLRFPSDNDATVTKEGRDYISLVSGAEEGTQSSTDSNASRRSSDQENRAKTSALRSFWQNLHTELFYDVTYWLLAIIYIIIQFVYTAWLVYYVPHTQAKGFSLSDVTIFTAISGLTRILTGLSLGPLLDKIKIIGNKGFMGITLILLALYYLIDPWLTSFWSTAVNQGVYGFAIGLAWLLADVLLCEAIAVDRLGSAFGWISMKSGILRFSLLYLPGLIYDLTRSYTLTFMLLGGAHLIGFAVLLLLVWLQRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A692</accession>
    <name>A0A914A692_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059382.1">
        <property type="nucleotide sequence ID" value="XM_038203454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A692"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203454.1">
        <property type="protein sequence ID" value="XP_038059382.1"/>
        <property type="gene ID" value="LOC119730499"/>
    </dbReference>
    <dbReference type="GeneID" id="119730499"/>
    <dbReference type="OMA" id="RITANWP"/>
    <dbReference type="OrthoDB" id="10101301at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037242149" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18358" checksum="E0A65E52ADF9177A" modified="2023-02-22" version="1">MMLGTLVLSLMLLSRITANWPDGSKDATRANMGFYTLNMTCNDAGTECEACYRARAEGLVYLHTVEYTEGPAKFEFRGSAASRDWKQFVVQDDPTEPFRYCMQQDEIQDLDYGGDTWRFSICMDNNFSGISVPAECVKPLAVVSMVSLRTDNEAHGEQTLYCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7P7</accession>
    <name>A0A914A7P7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059469.1">
        <property type="nucleotide sequence ID" value="XM_038203541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7P7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203541.1">
        <property type="protein sequence ID" value="XP_038059469.1"/>
        <property type="gene ID" value="LOC119730564"/>
    </dbReference>
    <dbReference type="GeneID" id="119730564"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12567">
        <property type="entry name" value="RRM3_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12569">
        <property type="entry name" value="RRM4_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12318">
        <property type="entry name" value="RRM5_RBM19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12571">
        <property type="entry name" value="RRM6_RBM19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000240">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000277">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000813">
        <property type="entry name" value="RNA binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034419">
        <property type="entry name" value="RBM19_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034420">
        <property type="entry name" value="RBM19_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034423">
        <property type="entry name" value="RBM19_RRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034421">
        <property type="entry name" value="RBM19_RRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="325"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="433"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="618"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="750"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="855"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="975" mass="109354" checksum="64F5B6CBB97FF4C1" modified="2023-02-22" version="1">MSRLIVKNLPKGIKEDKVRNLFAAHGEITDLQLKYTSAGVFRKFAFVGFRAKSSAPKAAKCLNNTFIDSSKLQVEIAKDLGDESIARPWSRYSEKSSAFQKKLTRQKEKEAAKEGKEKTTKTAVQQETDSKQKKKDKTKADPLHELEDDAGFQEFKEAHQVRSKKPLWSNDATVTDPRTTGQGLKVKGNESKDVSREAAEGSEDDTSSDEDAEMDEDDDDEEEMEEEEDAASKEANKPVSDMEYLQSKMVKKAAPVDTKSDTDSDTDSDMDSDTDSDADSGKDSLSEDEEKSTKKEKPQVQTQETPKTKLMKAVKKDDKFDRGQYVLKMRGVPFSVKENDIRSFFAPIAIKAIRIPLNEKKQRTGMAFVELNTEADLVQALKRNKDYMGKRYIELFRDEWNQGGQQGTREREAPWAKQAAELESSDEPIGETGRLFVRNLPYVCQEEDLETLFSKYGPLTEVNLPIDPLTKKIKGFAFITFMMPEHAVKAFTDLDGKTFQGRLLHILPGKEKKTAEAEGGDREGSSYKNQKKAKEKARSGSSHNWNSLFIGSDAVAEAIAQKYQTTKSQVLDTETGRSLAVRMALGETQIVAETRQFLLDNGVALDSFSQPSGSRSKTVILVKNLPAGTQATELRDLFAGHGSLGRVVLPPAGVTAIVEFIEPTEARAAFFKLAYTKFHHVPLYLEWAPVNVFKTEALSDPAADDTKGDRQSEEHTQEEGEQRTEANQPDAENKSTKEDAEEEEETEPETTIFVKNLNFETTEESIRKLFSQCGHLKSVTISRKKDPKHPGTMLSMGYGFVEYKKRKSAQKALKELQHSTLDDHSLKLKLSHRATSQATPASSRKGAGNIKQKSSKILIRNIPFEAKKQEIQELFGTFGEIKSVRLPKKMSGTGSHRGFGFVDFLSKQDAKRAFEALCHSSHLYGRRLVLEWAEAEETVEDLRKKTADQFIEGGQRKRLKKSKLKEDLELTMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8F4</accession>
    <name>A0A914A8F4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059711.1">
        <property type="nucleotide sequence ID" value="XM_038203783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8F4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203783.1">
        <property type="protein sequence ID" value="XP_038059711.1"/>
        <property type="gene ID" value="LOC119730757"/>
    </dbReference>
    <dbReference type="GeneID" id="119730757"/>
    <dbReference type="OMA" id="CVYFCYL"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="87"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="580" mass="63182" checksum="8F49B95C533A2969" modified="2023-02-22" version="1">MHLMNMASEASAPRLRGKTGEKLPLKDSTTVQGSAGLLDEAEAALKMLEYGSNSSWPKTTSDAAEESGDYSVNDAIDAIGVGWLQITILIMSFLAMLAVFAQILLSTTINEILRCTLKLSDDKVALISTMLFVGELLGTYPISKLMDTYGRRPGLILITCLMFFYSAIVSIAPNYVWVLILRLIAGIFVVGVQSSFMLYLGEITPSSFRALFVLGQVLFFGIGSVYVATLGYLVLPVMGWRFQCLFAAMPILPVMVAAWIFPESPRYYALTGSLKSAVETMKKIAAGNNKELPEGKLIQATIRDKEERSSVFQLLSPELSRQTLMLWIIWFCVYFCYLGIALSSGRLIRITSPLPPTAGNESLNLDIDPNSTLFIPPDPVAEGVVKAKPENVLRVATEDILPDHPHPRMTAPTCAEEDKEPVECEVIVSNSEYVDSVVASFGDFMAAPCIVVLVYTFGRKGGMSISLLLAASFMLCIIVTLGQIPPLVFIFLSRALTMGTYGGLFLYTMEAYPTSTRAIALATGQFFAKMAGALTPFVAESLIKRSPVDAILIYFFVCITGSITVCLLPLETQGMGLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8Z0</accession>
    <name>A0A914A8Z0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059901.1">
        <property type="nucleotide sequence ID" value="XM_038203973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203973.1">
        <property type="protein sequence ID" value="XP_038059901.1"/>
        <property type="gene ID" value="LOC119730908"/>
    </dbReference>
    <dbReference type="GeneID" id="119730908"/>
    <dbReference type="OMA" id="THWAVEI"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="36264" checksum="5F80C43FD47C4B46" modified="2023-02-22" version="1">MANQNGQGKPPGLVKLYGVTWPGMVTKEALDALKAYDVWEDDVWVVTYPKSGTHWAVEIVNLILVDGHEDKINRAQQSHPVEFHIKRPNAPPPQYEAMKDWKAPRVVMTHLTEELMPSQIYQGKGKVVYVIRNPKDTTVSNWNFVGKMKFDPKFEKWDDFVRESFSEDMMYGTWFAYVLNFWKKHRHDKNFLFLKYEDMKTDPKGAVIQISDFLGKNLSEEAIERVVEFSSLNSMKARFSQAKPAKEAPPQSPPADKASAPSSDEAKAGPSKTKFGAPSIIRKGIVGDWKTVFTVAQNEELDALYREKMAGSGLTIQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9K6</accession>
    <name>A0A914A9K6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060438.1">
        <property type="nucleotide sequence ID" value="XM_038204510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9K6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204510.1">
        <property type="protein sequence ID" value="XP_038060438.1"/>
        <property type="gene ID" value="LOC119731337"/>
    </dbReference>
    <dbReference type="GeneID" id="119731337"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="91" mass="10387" checksum="C363C9AEF10F34B3" modified="2023-02-22" version="1">MRTSESSLKDRYPRQRVLHRDGTDSKYCKVVNLLNALYTLFNAIISNYDVYKDESIDDAYMLVSCLLIRNGSRHAGMIASTAWHLLEGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACE6</accession>
    <name>A0A914ACE6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061595.1">
        <property type="nucleotide sequence ID" value="XM_038205667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205667.1">
        <property type="protein sequence ID" value="XP_038061595.1"/>
        <property type="gene ID" value="LOC119732230"/>
    </dbReference>
    <dbReference type="GeneID" id="119732230"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07603">
        <property type="entry name" value="BAR_ACAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000025">
        <property type="entry name" value="arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000026">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF399">
        <property type="entry name" value="BLOWN FUSE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="271"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="404"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="660"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="805" mass="88771" checksum="73D816AAC5808D23" modified="2023-02-22" version="1">MSGVVMNLKPKIGFEEALKDSPNFRSTLEESEHGIADLESKLEKMVKLCNTMVDAGKAYNNAFSAFIQGVKELGGHFTGDNLVQVYLMKFIHALSELQGFRAMLDDQAHRSVSRALGLFMKEDLKKVKETKRVYDRISDDLDNALHKNAQAPKAKPGGGDNEEVNNVLTATRSAFGHTALDYVFQVKLVQSKERHEVLNTMLSFMHSQFTFFHQGFDLIKDLQPSLKELGTQLQILNDRAKADKKDMEGRHPLVQKMESLWNVTFTPSAGPITMEGYLFKKTNNAFKTWHRRWFTVKNDQLVYQKRTKGGISIAAEDLRLCNVKPLDDIDRRFCFEIVLPGKTLQLQADNESIRQAWIQALQAGINSAYCLSPTQQSKPEDFSNQNAAPHVVNGSTSSTEPKSPSFKAKIQSLPGNDKCCDCKNENPTWCSINLGITLCIECSGIHRSLGVHISKVRSLTLDSMEPETLKVMLELGNNLVRSIFEARVDETVAMPASPNCSSAVRRKWIEAKYKDKSFLSKVPGSFRSTSLRPRSTSRIRRWRVAKPESVDRNKPPGTVRACSVKQEPGGSAGAREENFNDSGIGGSRDAIPVEPGKADEGSDSSDGEEQEAAKTKEIAEEPEFTATELLFQGSSSGNVGLMMDAIAHGAAVNEMDSNDDSRTPMHKAASSGNLGALEYLLLNRSKVNVSDVSGITPLHIATSVGNTGMVCLCLKRGAVQTAKDKDGIDPLAIAINSANADIVTLLRLARLNEEMKESEGLCGNPVEDDETFQDVFRDFTNLASNNPEALNRNFQEPDKPTSPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADA3</accession>
    <name>A0A914ADA3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061461.1">
        <property type="nucleotide sequence ID" value="XM_038205533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205533.1">
        <property type="protein sequence ID" value="XP_038061461.1"/>
        <property type="gene ID" value="LOC119732136"/>
    </dbReference>
    <dbReference type="GeneID" id="119732136"/>
    <dbReference type="OMA" id="KVCPTSE"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="304" mass="33552" checksum="5C57A497DC697C98" modified="2023-02-22" version="1">PNPNPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRSPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADW2</accession>
    <name>A0A914ADW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038061539.1">
        <property type="nucleotide sequence ID" value="XM_038205611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205611.1">
        <property type="protein sequence ID" value="XP_038061539.1"/>
        <property type="gene ID" value="LOC119732185"/>
    </dbReference>
    <dbReference type="GeneID" id="119732185"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 17 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="396"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 20">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="475"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="19">
        <location>
            <position position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="689" mass="77285" checksum="5409FE5AD5B4BEC4" modified="2023-02-22" version="1">MEGSHLTSVLGTNLTLNCKLRDDINITTGKVNFNWYFVDKLVSLCTEDRQPDGSSCSLVIGPVRASSEGLYKCTMFDGETFFESTTELTVVSPYTTMDLLDLSSGDLVDSNYSLSCVPLDAKRTFECSLRNIKPDRWNLSWLIDDSREVLGQFEVTSAGTGGLMIARSRFTVPDSDHKDLPDNLTCQATGVNGELFTVTVQLQFCSEGPLIKGANGVLIATVALVSVLGTLVVLPIVMFVKFRRNRREHNVQIKRSSVEMDVASDPDALGQPGQSEVGRSPGVDFEDRIAPRGPHKYEDKLATEDPHQYEDNIGHQVGYKYEDSISPQDPHNYEYNISQQVVHKYEDRISVHQVDEQEYDDTTPPQEETPMLPESDDDDNLPPWAEGWEVPRCDLIMDERVLGRGIFGEVRSGAVIKDGELTRAAIKMLKGHASTSEKDDFIDELRTMTSFGHHPNVVSLLGACQHRQVLFVALEYLSRGDLRSYLRTARSQSDSDEDALSSDQLVKFALDVAKGMEHLAKAGVIHRDLAARNILLSEGLTAKVSDFGLSRGEDIYVQTSKRRVPVRWLAIESIRYKRYTTKSDVWSFGILLWEITTIGGTPYPTTRSESLARKLKGGYRMPKPSNCDDKSFALMRKCWEEDPNNRPSFSELVSTLSGTDDSKIEHTYFSFNRVRYENLSVIQPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADX5</accession>
    <name>A0A914ADX5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062135.1">
        <property type="nucleotide sequence ID" value="XM_038206207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206207.1">
        <property type="protein sequence ID" value="XP_038062135.1"/>
        <property type="gene ID" value="LOC119732621"/>
    </dbReference>
    <dbReference type="GeneID" id="119732621"/>
    <dbReference type="OMA" id="YRINCES"/>
    <dbReference type="OrthoDB" id="6256226at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="143"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="797" mass="90495" checksum="341C505BD1D4CA99" modified="2023-02-22" version="1">MLKVSNEFGVGDEALIRQGTLRRKCSYPTCTFRHEITNYRHLNGGVPTSIKYLNTMSGYFQRSSQPSSMEPETSHNNSSTPLRLFVDAKKKINEIFGEIASHTRESKDFIAGIPSDLHVVSDDLQEKVQGFYTQVQGIREVLARDHMKVAFFGRTSNGKSSVVNAMLRDKVLPTGIGHTTDCFLCVEGSETNESYLQMDDSTQKLSVQNVGQMANALSNERICGQSSIVKVFWPKSRCHLLQNDVVLLDSPGIDVEPDLDQWIDKYCMDADVFVLVSNAESTLMRTEKSFFHKVSQRLSKPNIFILNNRWDASANEPEMEAVKKQHLQRNIEFLVDELKVVTRQQAEDRVFFVSAKEALITRIPRPSHTPDSSGPLADGFQARLFAFENFERKFEECISHSAVVTKFEQHAKQGKQIASCTQDILDEALQQSSKKRATCIEKRKEQTDRLQYVTSQLKILTGECKEKIKDIAEQAETKVSAAMTDEIRKLSLLVDQFDRTFQSDPLVIKVYKEELQKHLEAGLGRNLDARCTSAVMQDVQQVQEQMTEHMSALLPDEAKDQFSRLLFRRDFGPSYRLECQHLFADFSENVEFRFSLGFTSLMNRFLGPKNTRVAMAGFANVIPRPLASVGVESGSRSQEDMTVAMVTGLASLTSRTSMGLMIVIGIVWKAVGWRVLAVGGGLYSLLYVYERLTWTNKAKERTFKQQFVQYASEKLKLLVNFTGSNLSHQIQQELSTTFARLCLEVDNHTNDLKKELIKMEDESQKLEGMMSRAKVLRNKAGWLDSELDRYIHSYLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE20</accession>
    <name>A0A914AE20_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061736.1">
        <property type="nucleotide sequence ID" value="XM_038205808.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205808.1">
        <property type="protein sequence ID" value="XP_038061736.1"/>
        <property type="gene ID" value="LOC119732351"/>
    </dbReference>
    <dbReference type="GeneID" id="119732351"/>
    <dbReference type="OMA" id="RWKQAQY"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1856" mass="209743" checksum="B56BF56DA8A061EE" modified="2023-02-22" version="1">MYADNMSVVSSGEHSVKHHDGDSMCGDGERQGELVRPEDSASQLSSRTSTTKSSLGRTRKRLVAKMAALEAEAASLQEMQAIELEELKLRQRKQELALKTKMDMAKAEKLVYAIDEDCLHMTPPNSTPSPALSDKQESSKDSVPEAGDEQTPQKEPRYSPVDSPSNTTPKNEEPSVDKPKTTPMDDDNPEKQASLLELVKRGQQQQRCLLATMQLPRAELPTFDGNPLQYWTFLRAFENSVDNADIDDSAKLIRLLKYCTGKARKIIECCAIMQPDVGYQRAKALLKERFGSDYVIAEAWVNKVTKGAPLASHDRVGLREYADDLKVCKETLDTMGYTQEIGTQGVMVKLVEKLPSYLRNRWIKHVRGFRKSDKSPKIVNLVEFVEDAAQEANDPVYGNLHVSAYKPQKPEMRPKVTRPDKTSYALVTNSKMNEHVTCVMCKGNHTLFGCSEFKGKTPEERFNFAKAERLCYNCLRPGHVSSACSLHRVCSVTGCGKRHTKFLHPLKQTPSSSVGDARPAGLEATAQSSFTETDLGTSCVTGVGVYRVALPIVAVKVSAVDGDCSIDTYALLDNGSTSSFCTEELASQLNIEGKRQSLTLTTMTKAKVKTETTVVSLVVNSFDQQGAVNLDKVYTRHSLPINDDNIAEPEDIKKWPHLQDISIPQVEKGKVHLLIGQDSPDALVPLEVRSGETKAPYATRTRLGWSLNGPLGMSRRAAVTSSYVAVDDTLEQQLQRFWKLDAVESLYDDDKGMSVQDKRAIALWEKTVCLKDGHYELPIPFKNNPQRLADNRMVAEQHLTSLGRRLKRDCQLKARYTEGMKELVGNGYAEVVVGDDCVTDAAIWYLPHHPVLDSGKQGKMRIVFDCAAKHNGQSLNTQTISGPDLTNKLLGVLLRFRQEQVAVLADIRAMFHQVRVSPENRDVLRYLWWPDGDTSLEPAVHRMTAHPFGGTWSPSCCSFALRRTAEDNRQDFHPDTVGCVKRSFYVDDCLVSLATEAEAIRVSRELRELLSRGGFQLTKWLSNSPEVLESIPQEDRAVGVRGLDLNHEALPTERALGMQWDVETDCFGYKVSQKEKPLTRRGLLSIVSSIYDPHGFASPFTLLAKRIVQDLSRKKLGWDEALPSRHREDWQHWKQDLGKLEQLRINRCIKPYGYKDGVSYQLHHFSDASEAAYGAVTYLRMVNSAGLSHTCLLLSKSRLAPLKKVTIPRLELTAATLSVRLDAMIKKELDLPLEESVFWTDSTIVLRYINNEEKRFHTFVGNRVAVIQNQSSSHQWRHVKSGLNPADIVTRGQMADELLANQKWLIGPEFLRQDGHLWPSLPISTTLNDNDPEVKPEKEIVTVYATERKDSANPTDRLIARHSSWYELKRSVAWIMRVADSLLRRIRKQPAVQDMKTLTTNDLARAEASIIRYIQAQSFQEEFSHLKKGEDKIQKLKAEMKKKGQLYKLDPILTEDGIIRVGGRLRNAPGNMSNQPPILPKGNHVVSLIMKHYHLESGHSGREYVLSLIRQRFWIIKARSMLRRVLSNCFECRRRSAVPVQQKMADLPSDRVTPGRPPFSFVGVDCFGPFLVKQGRNQIKRYGCIFTCLTSRAVHIEVLHTLDTDSFINGMQRFICRRGQPIELRSDNGSNFIGAERELKEAWKGLSQEKVDKCLLKKGIQWKFNPPTASHMGGVWERQIRSTRRLLSSLMTEQVVSDETLSTVMCLVECIINNRPITTVSDDINDLEPLTPNHLLLLRGAPHSLGEFDKKEMYTRRRWKQAQYLADVFWRRWIREYLPTLQKRQKWLEPKGNIMVGDLVLIVDNDLPRNKWLLGRVLETYPGKDQLVRVVKVKTKSSILTRPVQKLCLLESVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE41</accession>
    <name>A0A914AE41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Graves disease carrier protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061756.1">
        <property type="nucleotide sequence ID" value="XM_038205828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AE41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205828.1">
        <property type="protein sequence ID" value="XP_038061756.1"/>
        <property type="gene ID" value="LOC119732371"/>
    </dbReference>
    <dbReference type="GeneID" id="119732371"/>
    <dbReference type="CTD" id="8034"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32775" checksum="9BADC04453142F58" modified="2023-02-22" version="1">MAALAGSGEIIPNFLAGGIAGCCGKVTTAPLDRVKILLQAHHRYYNHLGVWSSVAKVIEYEGVRGLYRGNGAMMVRTFPYGAIQFVAYDWFKKKTKRKLLSGSLAGVTAVLFTYPLDIVRARLAYQVQGECLYRGILHTCQSIWHQEGQLKALYRGVGPTLLGMVPYAGAAFYSYETGKAYVLVKGPTYLSKPSLADPNERILTAQANLVVGGLAGAFAQTIVYPLDVGRRVMQLGTMVPNSNPTSSCLETLILVYTKHGAQGLFRGVSINYLRAIPAAAISFTLYENLKQYLSIHLDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE77</accession>
    <name>A0A914AE77_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Migration and invasion inhibitory protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061664.1">
        <property type="nucleotide sequence ID" value="XM_038205736.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061665.1">
        <property type="nucleotide sequence ID" value="XM_038205737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AE77"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205736.1">
        <property type="protein sequence ID" value="XP_038061664.1"/>
        <property type="gene ID" value="LOC119732279"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205737.1">
        <property type="protein sequence ID" value="XP_038061665.1"/>
        <property type="gene ID" value="LOC119732279"/>
    </dbReference>
    <dbReference type="GeneID" id="119732279"/>
    <dbReference type="OMA" id="KHTCIHN"/>
    <dbReference type="OrthoDB" id="10002384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031466">
        <property type="entry name" value="MIIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34831">
        <property type="entry name" value="MIGRATION AND INVASION-INHIBITORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34831:SF1">
        <property type="entry name" value="MIGRATION AND INVASION-INHIBITORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15734">
        <property type="entry name" value="MIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63960" checksum="950A026D6E8F2DCB" modified="2023-02-22" version="1">MTEDLSDMERLRAQNLSLLKELQKGQRDLRASIRSTGANRGSPLKESSVKFQRDLLDVSTMSSVRHKPTRDAPHSRLTSTPKHTNSATKPRGGSHPQDEPFPNPPVVDPVPTATPTRLYESFLSESHSTFGRSSGKRDKAKTVKQTRRKTPGSSTKGTTGSIKRKSRTPRKSPKYRTGASVTTFTPSPNKKGPKIPYSVRLETSSLLPPPLSEKENLRGQGSRYGYRRPLDLAHEESYYQLNRDSPLRTGPQMGQLERSFAGQLLADGNDRRQRKRSQEVTTQPKSILLTPGTRLNKSRNRVSFRRSPSASATFDPDDSLANRSQPLLGYDWIAGLLDSDAPVSEHSEAFFDELRQFRQANREECIHKATTEKLDVSALTASVTDDLQEDMKPDRHTCIHNYTLNPRLFAVPLHGTQNGQSLCAICNDRRKPKQPGASSPSYIRVSIPRSTLASPYRLRPHRRKSYDPTDSVGLSQHCLAGWQSSKPSMLPTASNIDLKGCVDKMASSALNLMSYPSQEPSFRCENAARISKHTQELLNRSHALQLDLQKLERVGMSVARLPPRPHSTSYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEX2</accession>
    <name>A0A914AEX2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062061.1">
        <property type="nucleotide sequence ID" value="XM_038206133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEX2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206133.1">
        <property type="protein sequence ID" value="XP_038062061.1"/>
        <property type="gene ID" value="LOC119732566"/>
    </dbReference>
    <dbReference type="GeneID" id="119732566"/>
    <dbReference type="CTD" id="27247"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="280" mass="31040" checksum="8357910DF2FD8061" modified="2023-02-22" version="1">MAAYRRGLTQSLRRIYVINSTRVANGRVQSEPTAVRGIHILQSVNTTTQGNSKQLLQRWAPTPSIQQARSMFIQTQDTPNPNSLKFIPGVPVLDQGGTVDFPSARTAHNSPLARLLFRIDGVKGVFFGSDFITITKVDDDTTEWAVLKPEIYATIMDFFTSGLPVMTDEQPAADTEIHEDDDETVAMIKELLDTRIRPTVQEDGGDIVYMGFEDGIVKLKMQGACTSCPSSVLTLKSGVQNMLQFYVPEVIGVEQIEDEADHVTSEEFDKLEKKLGEEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFL7</accession>
    <name>A0A914AFL7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical S-adenosyl methionine domain-containing protein 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putative heme chaperone</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062293.1">
        <property type="nucleotide sequence ID" value="XM_038206365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062294.1">
        <property type="nucleotide sequence ID" value="XM_038206366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062296.1">
        <property type="nucleotide sequence ID" value="XM_038206368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206365.1">
        <property type="protein sequence ID" value="XP_038062293.1"/>
        <property type="gene ID" value="LOC119732719"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206366.1">
        <property type="protein sequence ID" value="XP_038062294.1"/>
        <property type="gene ID" value="LOC119732719"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206368.1">
        <property type="protein sequence ID" value="XP_038062296.1"/>
        <property type="gene ID" value="LOC119732719"/>
    </dbReference>
    <dbReference type="GeneID" id="119732719"/>
    <dbReference type="CTD" id="55316"/>
    <dbReference type="OMA" id="CDNHLSL"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="COPROPORPHYRINIGEN III OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF5">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01065">
        <property type="entry name" value="anaerobic_coproporphyrinogen-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00288">
        <property type="entry name" value="HemN-like__clustered_with_nucl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="109"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="524" mass="59129" checksum="DE207EEEC80AB991" modified="2023-02-22" version="1">MFFIIANHLKQKQDFHRVNCFTSKKMKFLVSRITHAWRSQRLSDYVKSNVPPLHVLTSANKTARNICSTCRKVQSCPPTVKQQLHLSSSVVQPAPVDTTSPELDHQPSTAWMDEATLYVHWPYCQRRCTYCNFNKYIDSNVDHTKMQQCLVREVQTLIDMSGIKRIKSVFFGGGTPSLAKPQTLQAVLDTVAGVVDLPSNAEVTMEGNPTSVGRYKLRDFKHAGINRVSLGIQALNDDDLNVLGRDHSTTESMHSIKEAQKLFPGRVSLDLIFGRPGQTLPSWEQELQQVLTLCDNHVSLYQLTLERGTELFKMHAKGEVALPADDDVADMYIMAVDMMEEQGLRRYEVSNFAREGSECLHNQAYWEGGQYIGIGPGAHGRFMLQKATSRSGKSEVKQGNFETLREARIQTLEPGPWMFEVLKYGHGTRKRVCQTQLDVLQELLLVGMRTSRGVTSKRWAELSGGCLSEVFCDDNVQRLVQDGLIVKDRTGLRATPHGMVLLDSIIPHLILTLQEWYTGFLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGD7</accession>
    <name>A0A914AGD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063040.1">
        <property type="nucleotide sequence ID" value="XM_038207112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207112.1">
        <property type="protein sequence ID" value="XP_038063040.1"/>
        <property type="gene ID" value="LOC119733733"/>
    </dbReference>
    <dbReference type="GeneID" id="119733733"/>
    <dbReference type="OMA" id="GIFINCG"/>
    <dbReference type="OrthoDB" id="10057873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272:SF161">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN RICESLEEPER 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="178"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="257" mass="29003" checksum="798C7B9B03B0BBF7" modified="2023-02-22" version="1">MSWGDKSATITQVVPVVLDINSHLSKWKDDARVCKTLVTALHKSLKKRFRGIFINCGMDTEPGSGSHQEPFIEKIYLVGAVLDPQYMLHWVDADVVFTGSPEKSKNKLKDTLKEMVITEAERFVSNAEEAASLSHTSSEEEDIPAKVPRLLAKYKTIRSRTKSGEKDSVRIQLEKYIRDEERHGLDAVTFWQDSGEGKNKYPSLHALAKNILCVPASSAPVERIFSRGGLIMRPHRARLTPQMLETLMFLKCNEHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHK1</accession>
    <name>A0A914AHK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063475.1">
        <property type="nucleotide sequence ID" value="XM_038207547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207547.1">
        <property type="protein sequence ID" value="XP_038063475.1"/>
        <property type="gene ID" value="LOC119734194"/>
    </dbReference>
    <dbReference type="GeneID" id="119734194"/>
    <dbReference type="OMA" id="FAYCINM"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="92"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="630" mass="68984" checksum="819F9EC716570509" modified="2023-02-22" version="1">MDPDKESNEQRQVRFARVLASYQAAAVVDGAAKPPSTMESKPTGLAAKFTDDGSDYGSLSGGDADRDNPCCFIGPDEATLRYCPMNEGMLPFKLLYIFFRGGVACIGPYLSVFLSLLSLPPSMVGVLLGLPHLVTAFVNPACGILADRFQCRKGVLLVCLSLWFAFVVSVTFPKPLEPANCQEVVSNLGQVSRTLSKNSREFLHLECIVNRSSDEYSLEEKGRPSVGADQDRWKPLLSLLHLPDPFSPDLGDTCASMATRDLDDPIRSLVKNIQTFGALFIPRVIPLQNGTSIGIGWLFEERSLLQSFIKVSVLMNLGGVMYRSTMALTDTATLNELGEQAWDRYGWQRSFGSAGFAVYSIAVASFLGLMRFPQILCGLEIEIIDYRIGIVMFGGTVACAFGLLFACCFKFKYYTKAEYKFSNVLPALCSGYYGSIMMTAFVLAVCNGCVDGYLFWHLRNLGATEITLSLVLAVRAGSELLLAFHTPRLIGCFGPVHLLCAGLLVYCLRFLCYAYVTNPWLVLPVEVLHGMSIALTWNILVSHMSPSVPFECMATLQGFLSGVYFGLGHGVGAIITGFLVTSYGAVATFYGFAFAAMCYTIAFLIAVKVFKPPRTIVTSYRMLSSKDPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIZ8</accession>
    <name>A0A914AIZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063526.1">
        <property type="nucleotide sequence ID" value="XM_038207598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207598.1">
        <property type="protein sequence ID" value="XP_038063526.1"/>
        <property type="gene ID" value="LOC119734227"/>
    </dbReference>
    <dbReference type="GeneID" id="119734227"/>
    <dbReference type="OMA" id="MEREMYQ"/>
    <dbReference type="OrthoDB" id="10255247at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="541" mass="63926" checksum="164402D0DB8B093E" modified="2023-02-22" version="1">MTSAKQDGAMNAWTVYDHIDECRGKVALKERDHRAYYESSQVDKQFNEVEIAALRQNNKDKRVNLAQQTFHGDERVINEALESHRDENLALRRKTAEEAISEMDQKMCEKEKQLNSLREQREKRENRIKELETALARLDLLAKNSDNNYAQYDLKTIRMVENNLDKARIKHETARKLQQTYIEIVRCLEEERLSLPKKLKALEGALEEQRHELRELTGISQDARIKRDQAKAELSVLEQTMIEAKRSRDRTLTRMKKQAEKQKEMADKIEKRARATLQTDDPSQESKRQSQMDEDNWVKVTTYEEAFKRIQEATGVSSIEEIEARFMNQGGTYEHLLAQKRTSEKQRKWLSEQKRQLTQHYEAMKYSGESKMSQGQQMLEKMQEHLGKTEQRRDLLRNSVHRNHMVTTDVKNGIRHLYDTLKDIKLKPPMKNNANPDDYLDQLQICENKLQKLMTQANVRDSASFKKIMNSTEFHEFMENRQKTENLRVRLDEPDSYDSDDFGYDSQDNEDMMTNADIKREGQMLMDQKKNKKRARGRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJK7</accession>
    <name>A0A914AJK7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064169.1">
        <property type="nucleotide sequence ID" value="XM_038208241.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064170.1">
        <property type="nucleotide sequence ID" value="XM_038208242.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208241.1">
        <property type="protein sequence ID" value="XP_038064169.1"/>
        <property type="gene ID" value="LOC119734703"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208242.1">
        <property type="protein sequence ID" value="XP_038064170.1"/>
        <property type="gene ID" value="LOC119734703"/>
    </dbReference>
    <dbReference type="GeneID" id="119734703"/>
    <dbReference type="OMA" id="REPKFEI"/>
    <dbReference type="OrthoDB" id="5973359at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000275">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF7">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN EAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324111" description="non-specific serine/threonine protein kinase" evidence="16">
        <location>
            <begin position="31"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="176"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="637"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1163"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1215"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1479"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1245"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1261"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1479"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1518" mass="161892" checksum="77AFE0DCC16E7A98" modified="2023-02-22" version="1">MKVQSSLPKMVRHGLLAAVLILAVCELIDAASLADTRESVMNATGLSDMTVISILSVASCLCLIIAFVGCASCCKTGFAQKFEDTTTETTVVGEQYTRFSDFSPPTMSTPSRPPGSHEPETVTIEPLPQLPGRTSNQWVNVIRVSGGTGGGLDPGQTLQSIKLIDSPRFQFPRGQISYVDEMGNGWFGKVLQGEAQRMHPGLRKSRVVIKQLRDTATPEEQLLFLQEVQPYREVNHPNVLLLLGQCIDSMPLLLILEYAPFGDLKSYLRKHRDDVQQMAQQDIQLKMAADIVSGLMWLHQADFIYIDLATRNCQVSADTSVKIGDYGLALEKYPDDYYITKDNTQAIPIRWLGPEVIDLAEDGTVKTKKITKESNVWSFGIMMLELSTGAKRPYAKLTDEQVLQQVVKEQEIRVDKPNLSIHYAARWFEIMMYCWLEADIRPTMKELHDLIQYLKDHRDRVDMPDFEARWNNLKPAALQESSESGKEDEVAPPSTIQKNPPGFDDDFISQQQNEKPSPTKQSPVIVPPKAKQESPAKTVGFNSDFGSAPVAFIKSPPENVTDMPSPNRNMNAETGTAGDQPLFDDDFVTAVVQPTIEAAPQPDVPVDQFQSEFVTQVEVPATQSAPLFLVQDGGINIKDETPKPVLQSDLVPSSAPTDETSPDISLQAPQEISFDEPQPELDAEVQRTSTPVVSEEHYDPSANFSMVSPAADHDPNTFISTSSLSLSKTPTPNEDSITFHSMATPDSKDQTEFLSFDTANTTPSTNYLTPTKDHTPTMDNTFDTTTSFQDEEPTFIIKTDTTPVDVQSTDPLSAPLPADHSPTEFTTFVTGEAHPLAAEDQSAAAVPSSDVTPLETNESLVVQLSTPTPADHSPTEFTSFVTGEAHPLAAEDQSAAAVPSSDVTPLETNESLVVQLSTPTPADHSPTEFTTFVTGEAHPLAAKDQSAAAVPSSDATPLETNDSLVVQLSTPTPADHSPTEFTSFVIGEAHPLAAEDQPAAAIPSSDATPLETNESLVVEPPGEDTLMQSGFFDSTDSSFATPQQAPRDLSSLSLLPSTETSQIVSSPFTITMSTDGAGSPLEGALSVHSGTGNGTVSHSFTSSSSSSSSTRVMKTTRTVRQVRIVGGQEIVMEGDGETIEGDGVVSVVPGADGDGTVIQTLSGGELQTSSSSFQSTQQTSSSMMRQTSGSEQLASFTVTPGGEMTSSDGTISVTRQMSGEMSSSSSTSSVTRQVSSQQVSSLTSEMSGEATSMVWQMSGESTSSMTRQLSSSSSSSSLTAASSSKVVTSQKTVAEASALQQVSSSNNAISGSGDLTFMLSGDNALKQMGSSSTSVVSHSSSSQSLSRSEMSSQVVSSSEQSGEAPSNVTVSRSMSASASQQQQSSSVQIMTQSSSNAQQPVAFDLNRLSLDAANGNSLVEGEPGTTVQKTMKVTTGPGQVSVGQAMTMQGGGSDVREMENGTKVSVQWQGSAAAKQEHSVFSTEFTTDGSSGQLEGLPGQSSQLAVTLPEGDSTSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKB9</accession>
    <name>A0A914AKB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transposase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038064016.1">
        <property type="nucleotide sequence ID" value="XM_038208088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208088.1">
        <property type="protein sequence ID" value="XP_038064016.1"/>
        <property type="gene ID" value="LOC119734552"/>
    </dbReference>
    <dbReference type="GeneID" id="119734552"/>
    <dbReference type="OMA" id="WTEWEAN"/>
    <dbReference type="OrthoDB" id="10009406at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="5">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51032" checksum="EDD3128D49341CAA" modified="2023-02-22" version="1">MPGYLLFTQAIICSIHFQDEKPSKNNPYPSLHMGYKPHKQLSSGRHAPRLRRDLKLQEQESVSVSEHAVHEMPHASPVCGETILPASLATTCKDASVQWYDFSTADHTYATNPSCPMKSQVKATQTRQTDTSPELSASDMGDDTSKFYTGLSVHVFWALVKCLSILPNLPTFKMKLCNQLLLVLMRLRLGLFFFDLGTRFKVSQSTACQIFREWIPILARFMREHLIFWPSRDTLQRIRPRCFLEHYPRATCIIDCTEMFVQRPRNLKQRAQTYSNYKHHNTFKLLYCIAPNGFVMYLSKLFGGRASDKFITQSSGILQHLQPGDEVLADKGFTIDDILPPGVKLSIPAFTTGNKDHILPEEEVTRTRRLANVRIHVERAIRRLKCYKILSTVIPGRVMNVDNIVTVCAGLCNLQPLLIQGEPETEEMITESDDDFEDEWLFEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKC6</accession>
    <name>A0A914AKC6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063864.1">
        <property type="nucleotide sequence ID" value="XM_038207936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKC6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207936.1">
        <property type="protein sequence ID" value="XP_038063864.1"/>
        <property type="gene ID" value="LOC119734433"/>
    </dbReference>
    <dbReference type="GeneID" id="119734433"/>
    <dbReference type="CTD" id="6158"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="149" mass="17077" checksum="754281E2E80A3C9B" modified="2023-02-22" version="1">MRIYPAVMNNAAPDLQWMIIRNNSCFLKKGNGLTFSSEPNNLKNKNTFKFNGLIHRKTVGIEAAKDGKGVVLVTKKIRGVANKPAKQYSRIELKKDARRTLTSIRHVLKKNKYRRDIKNAALRRASAILRSQKPVMPLRKKRGSRSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKE5</accession>
    <name>A0A914AKE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064041.1">
        <property type="nucleotide sequence ID" value="XM_038208113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208113.1">
        <property type="protein sequence ID" value="XP_038064041.1"/>
        <property type="gene ID" value="LOC119734576"/>
    </dbReference>
    <dbReference type="GeneID" id="119734576"/>
    <dbReference type="OMA" id="PILYCKT"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="47"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="382" mass="43732" checksum="C08813575BAE5796" modified="2023-02-22" version="1">MEIMLDEGNMNESQPPTTTTDTLADDLPALVAMTVYMSLLAIMGLIGNILVIVSVAISPRLRTTSYAFIVNLSVTDLAVNVLVIPVMTVSFYNYGWPHIPFWCRFVAYIFCLSIGISFVTLTMIAANRYSLVSCSRRVRLKYCGWKGTTLCLFFNWFSAFCLVLFQEFYYKATVRYDTVLRFCYPDSSEPATYWYLSAILIYGTLIGFILIPILYCKTFHSLQVSRRRTETWARPAGKTRPRKQNNQSQRRVHPAEVKLTKLMAVIFTVIIICWTPLWVVHFFKLTYDIPKGVERLCILLVLTNSSINPYLYAWLNKNFLRAYKKVLLCGRNRKDQFYEELNTTIRGIPVVEQLYLLGEFNARVGSDHNSCPAASLTLALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKE6</accession>
    <name>A0A914AKE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064460.1">
        <property type="nucleotide sequence ID" value="XM_038208532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208532.1">
        <property type="protein sequence ID" value="XP_038064460.1"/>
        <property type="gene ID" value="LOC119734902"/>
    </dbReference>
    <dbReference type="GeneID" id="119734902"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="284"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="338" mass="35610" checksum="F322A6DBB5BE15F6" modified="2023-02-22" version="1">MFGLIARNSSRRICQSFSVLSRHNSTLVIVEHNNESVTPITLNTLTAASKIGGDVSCLVAGTGCGKVVEELSKVPGVSKIMVADNEAYKGFLPEALTPLLVATQKQFNFTHITSGATAFGKNLIPRLAAKLDVSPISDIIGIESPDTFVRTIYAGNAVSTIRSLDAVKVFSVRGTAFEAVEVGSGSAASEQAPEPGATNDLSTWESQSLSKSDRPELTSADNVISGGRGMKNGENFELLYKLADKMHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDPEAPIFQVADYGLVADLFKAVPEMTEIIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKM8</accession>
    <name>A0A914AKM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hemicentin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064282.1">
        <property type="nucleotide sequence ID" value="XM_038208354.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208354.1">
        <property type="protein sequence ID" value="XP_038064282.1"/>
        <property type="gene ID" value="LOC119734796"/>
    </dbReference>
    <dbReference type="GeneID" id="119734796"/>
    <dbReference type="OMA" id="QGPQTGH"/>
    <dbReference type="OrthoDB" id="10062639at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037138905" description="Hemicentin-1" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="644"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="833"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1565"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1624"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1280"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1376"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1391"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1482"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1509"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1571"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1628"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1652"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1672"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1682"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1696" mass="187905" checksum="B7383A2D08111BB1" modified="2023-02-22" version="1">MIPSELLSPIIILCTVRLIFGTPSTHLSPEMSAALHLLRPEAKVSFAGACLGEYRCSEAEVASYAWQSSHADTAVRKRFWHTYDCTWNEDPSQCPVDGGWSSWSEWGDCDTTCGDGTKLRYRACDWPQPKNGGNECHGQNSSVTSCRVKMACPPPDNDSTVTKGSPGESVQHKALLAMEPFNKGNAELQSACMDGRCSYQQVTEMVTPRNLADVYWTNLICYKHFEGCPVDGGWSEWSMWSSCSSRCGTGKAYRSRRCASPQPRHGGRYCDGTEYEEGMCFDDSCVEAVGVLLTPWSMWSACSTTCNDGVKTSTRRCHGSDVCDVGKGQVAALLTREIPCSGGLCPEVGGWSEWSAWTVCSAICSKGRRVKERACNKPRPQGEGNDCEGESFTEEECSQHAPYCEGIPEDVTMYEEWSHWSECSAPCDSGMTIRHRTCLEQGHPCRGELYDLQLCNDDLPCKADGDWTPWTEWSVCTVTCGEGDTERYRQCSNPRPEFGGLSCEGDADEKKKCLLSECPADTPTWESWGEWSQCTVTCAGGTSTRTRGCLVSYGNGQEPRQVPFSRCAGEYQQINVCNYLPCPVDGNWASWGDWASCSRSCGDGVVKRDRTCTDPAPAGEGEVCGGYGTEIVPCYQQPCPVPDEILRTFDGSAFMMYHRAAAPSKLLLFYMRFMPSNPSSLLALRHDDVVHSEQMVTVGVANGHVRVYAKLGQAESVVVSSNGIHLNKWNRVEVTISGGHTSVRLNDGAPVFSNFTLPLPAHLDWDQSMYIGGALPYLFPGPAREYVGFVGAISALRVNYKEYTLHDIRPEWTGVGLPFVSFDVGTRLADINAQVTVFTGREYTFLPCPNTTDEQFSLKLTLRPDGPDGIVSYVMGLVPGSFVALTMMDSRVALFVSFGDSIATAKSVDIALSKWAIVELTLRGREAEMRVNGGPAIQLAVEGTDFAPAPRVHIGGVPGPDRTVARMTTGWDRGLVGAVYEVTVNRYQYLLTETALNMEDMYLDSASTTISAHYREVRRPLHSSVALHCNYANIRKEKPMVTWLYGDKILEESTHVSIFKPSVFSPHKSILNLHILQSDNEGPYACMVWYRGKAVITHAFGVSIYEPKEFEFHLESNVELMVIGNVALIVGFIIGIIALSCFRVCRRRFFFLDMMHQSTVFYFGLDEWAWLRDPDVPDRATMLQVNATFDKDFSAREEKIKFDQALKKKKTLEQLKTKAKEVKGKMKRKKTKKNKGDVESGLDSRENAENATEKPGKSPEKLKKIKRKETKNNDDEESTLDSKKVENATEKPENAAQHKTGKTPEKVTLLEQLKTKAKEAKGKMKWKKKTKTKGNVEVDLDSRENADNATNKKQEKGTTVITVTPNEALEMTAESSTKHSERSEEGPEVSLKSSQIHNNVNQSAGTYGSLLQRKPSESLSDREINLRRLSHEIVTGKPESSTSSSSHGGESPEPRPVNGDSVSSLVIPEDKRQVDLIELDDQERRGDWEKEEPLYVNIDTIRDRRRQSKSSLGSLRLSQRGSSSTSNDSEPPPAPPRLLPSEETVEVDMDAVRENWRQSISREILSDYGASKSSATEVLSTQDRRRQSMAQAGHDAGRLFNHRGSIGGAVTKLSEAVAEDAIAGFGEMNDEGSEEDEMQDEDNARRQLSLVLEEEDGEDQPLLDQASSASASDEDEDESPDDNEKNFLIAERDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKP1</accession>
    <name>A0A914AKP1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064136.1">
        <property type="nucleotide sequence ID" value="XM_038208208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKP1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208208.1">
        <property type="protein sequence ID" value="XP_038064136.1"/>
        <property type="gene ID" value="LOC119734679"/>
    </dbReference>
    <dbReference type="GeneID" id="119734679"/>
    <dbReference type="OMA" id="RIRCVLM"/>
    <dbReference type="OrthoDB" id="10059150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="14">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="13">
        <location>
            <begin position="254"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="12">
        <location>
            <begin position="473"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="11">
        <location>
            <begin position="648"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="820" mass="89715" checksum="997A12EE89D94728" modified="2023-02-22" version="1">MQSGTQSRSAVCSEKVISEVSGKRLLRRRVQKRADGAKCVTVDGRTDWDELCKQNTWLRTQSGLVVKPDQSIKRRKHLGLIQLNVDFDTAKLWIQEKLGSKVKVDGVEGTLKQFLIEPYLPHQENEESYLCIYCHTESHDAVLFHSKGGVDVGNVDEEADHLYVGLEEMPQQQTIQETLLKNVQNTKTQMLCSFIQSLIKCFRDLHFTYLELNPLVVTDSEIHILDVAAKVDSKAAPLCKELWDGIQFAPSLCRDLHPEELRIAQLAAGTPCSMNLTILNKAGRIWSLIAGGGTSLVMSDTAAELGVRDEVACYTQFSGRPSADQMYEFTKTLIDLMVEVPHPEGKTFILSSNVADMIMMIKLKVGPMQGLMRALQECKEKLKTHKISLLMRRATLATVPKGQIPSALTELGLPVHIFSIAVPMTHLIQCALGLRDVETGVDDTDKICQPMNQQAESHEVIAKNNLDEIFNGDTKVIVVGLMTQAVQAMLDFDFVCGRKTPSVAAIVNPGGSEDKEESFLWAEGQVNIQVYSSLETAMSNHTDATVVVNGAPGRDAYHCAMLAVKCRHIRCILMIAGHIPDRQTRTLVQMAHNNGVLIVGPCTPVHLMQVNFIKPGSFRCNKFGTIGGSLDDLVSLRLYRPGSVGVVTRSGGLSMELIIYIARNTDGLYQGVSLGGGKCTGSSFMDHLMSMQANPDVKILLLLGEFGGSEEYDICEALCSGKLSKPMVAFCIGECADMFKSEPGYFGHSGAGNDVALETAAAKNQALAEAGAVVPKTFDEIGEKLREVYASLIAKGQLVPKPEPPVPSIPANMKPRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALL2</accession>
    <name>A0A914ALL2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064436.1">
        <property type="nucleotide sequence ID" value="XM_038208508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALL2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208508.1">
        <property type="protein sequence ID" value="XP_038064436.1"/>
        <property type="gene ID" value="LOC119734886"/>
    </dbReference>
    <dbReference type="GeneID" id="119734886"/>
    <dbReference type="OrthoDB" id="10070172at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="40480" checksum="3B5ED433347249BD" modified="2023-02-22" version="1">MANVGDSNWSLGASTGSLGSTSSTPRLCTYRGMYRGSGSADIMSPQQLSPCMDSVVESPTTSCSSKERDRHSQTMDVAHIRLRPEIKPDLPSSVPNSAREPLPGYSPSHHRDPANHRSVNEQLDKYMVIRQRSFHGYARSKQDLRQLPQTDPREETDTIPNWLHRSKTDIYIERRRAKLASQRARRRGGSGGYNLDGITLGSLVNQLPVPGKRDYNGNCKLDSSMTVNPGSLTGECREETRFPPLTMNRMKQMIRNDIRTYTIESQATEHRRPSTTSALPTSSSTFPVPDPPPNSPPPQTREPTGHKRGRLRKQPLGSIPLRIWEPSLDYVLRSNAKELQPRQAVPSFAHQASVRQQPSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN84</accession>
    <name>A0A914AN84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064961.1">
        <property type="nucleotide sequence ID" value="XM_038209033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209033.1">
        <property type="protein sequence ID" value="XP_038064961.1"/>
        <property type="gene ID" value="LOC119735336"/>
    </dbReference>
    <dbReference type="GeneID" id="119735336"/>
    <dbReference type="OMA" id="GRRMEKP"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="284" mass="31745" checksum="C12841011FF3F159" modified="2023-02-22" version="1">MAPSEEIDVISQPANQEPRTAAYANTPTTHKAFPRDQLNIIKELGHGAFGQVLLAEASGMTQGSKVTLVAVKTLKDGAGQSDKADLIRELDLMKKLPDHCNVVRLLGFCVEEDPPYIIVEYQSRGNLKDLLEDSRSKGRRVYGNRHGLSNTSKDLMKFANDVADGMAFISSQRCIHRDLAARNVLVAEDMTCKVSDFGLARDVMDIRVYERRSQGPLPMRWMALESILNDVYTTESDVWSYGVLLWEIVTLGARPYPAMAPSEMIDKLQSGYRMPKPQHCQEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQF3</accession>
    <name>A0A914AQF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038065868.1">
        <property type="nucleotide sequence ID" value="XM_038209940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209940.1">
        <property type="protein sequence ID" value="XP_038065868.1"/>
        <property type="gene ID" value="LOC119735964"/>
    </dbReference>
    <dbReference type="GeneID" id="119735964"/>
    <dbReference type="OMA" id="FTHKLER"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="470" mass="55875" checksum="BD00A9385734F9A3" modified="2023-02-22" version="1">MMRRLRYYVMTHPWTGWIAFLAVIILWFLSSTVLQPSLISARKQQEHRAKRREAARAEWRTYTTMLDIKHNASAYSRSRPTDETCFFTHKLERPDMPTIHSAFFTPESNSVVFVGVRFFRDKWNERFVCEFQNGETTANDPMVDDYRSFGYLPQYVFVMTCPLPEAYLRKNNFTMSLHKETWRRQWYRYTYTNFTVCRGVGSKPVAKKRFLSVCTMVRDMDNFMSDWLDYHKFVGVEHAYIYDNAPEDLSLLRETVKEHIESGFVTVIPWSHRSSQEKSYLEVQIAHENDCLWRHRYNSHWMIKIDVDEYIQPMNPSMSKIPEYLRDPHLDHVGAVRLQNWFFGRPNLTEFAPGSIIERNRWRSEDPTLSNTGRDKNILRPINVHYFKIHAIKLGGEARSVDPWTELRLVHYRGDNPRIRHFDLPEFSVLDESVVNIWQRVKKSKLRDLVDPDSGHDEKGSQIVKLLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR50</accession>
    <name>A0A914AR50_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065914.1">
        <property type="nucleotide sequence ID" value="XM_038209986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR50"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209986.1">
        <property type="protein sequence ID" value="XP_038065914.1"/>
        <property type="gene ID" value="LOC119736000"/>
    </dbReference>
    <dbReference type="GeneID" id="119736000"/>
    <dbReference type="OMA" id="MTRPGCS"/>
    <dbReference type="OrthoDB" id="5949187at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="392" mass="43494" checksum="81DA6FA5D4DCED89" modified="2023-02-22" version="1">MIDFFFLRKSQTSCLADCNMSFGGLKWLTVVFTVILVWSGECYGVSESCGELAHRVVRALDGALGFFDREYDKVNLDAVVGVRMAQSQLQAALAELDAAKPPELKSLQDELQKLSDQAETICDRAIPVVKRQYPKDYKDLGLLISGDFWNAGSTAEKRQTDRSLGSAPRQDEGWEPLSEPLTDRCISQLLGTKTEPCSITSFCWLAMTPRGYRSYSLSHQVLYLTVGSMMGCESHMIKRLHTPDETDRTGGSMLDSLTDGFCSDVLREAEATAGEGYPTGSQDLFMEQVLLCGLKGYEDFFRLPWLQAVLSWQDASGCFKNDVYRPHASDVDLDDPKNADVSGHVRIRRRENEVSGTGCLMHKTAVGTGFLSIYLRMLIDTMATGETVTNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASD7</accession>
    <name>A0A914ASD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066369.1">
        <property type="nucleotide sequence ID" value="XM_038210441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210441.1">
        <property type="protein sequence ID" value="XP_038066369.1"/>
        <property type="gene ID" value="LOC119736422"/>
    </dbReference>
    <dbReference type="GeneID" id="119736422"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433000" description="Ig-like domain-containing protein" evidence="13">
        <location>
            <begin position="34"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="38279" checksum="F8FE559CE888A6D8" modified="2023-02-22" version="1">MAGAVMLSTMIQAHKPDLWMVLVVSLVVICIQARSNDDGTIFLERGNPGILSCPPVASGRIPLDQIDVMYWYFPRVRDENILISYFLGIVAPQNGILDGVYDINDNFSLVIENVTDSDEGTYYCRVKPKLEVMVDGQVTKRVKVSPKEPFPDVTQCTELISETACEAELPNDIKKPRLTCIVRDAKPAVALRWLLEYSDGDTQLIGERFTVQPSEYLVNTFTTSASIPVIVSDGDKFTYICQAYGEALGARNGSHVTPQTLYLTSTQPTTSLTVMPSMLGFTSAMKDAPDSSQNAVIGLAVALCLSLAVVVGLVSAVCKMRKPGQTNGIQLPADNHTDCETTDPLNEQSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASP7</accession>
    <name>A0A914ASP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066688.1">
        <property type="nucleotide sequence ID" value="XM_038210760.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210760.1">
        <property type="protein sequence ID" value="XP_038066688.1"/>
        <property type="gene ID" value="LOC119736749"/>
    </dbReference>
    <dbReference type="GeneID" id="119736749"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000185">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF560">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037779220" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="515"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="616"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="715"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="810"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1012"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1188"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1298"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1472"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="946"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1578" mass="173869" checksum="B1BE21D3F39F0A20" modified="2023-02-22" version="1">MASLCLCRLRDVVLPALFLCAVLLPNKGLALNLRDKPTNQSTTTDPADSLPENAVDGNLYTISYTNLCAGDRWWRVDLEAIYCLKKITIINRVDGYGKRLAGAVVRAGLDPSDFSENTQIGDAVRSSQATNGATIDFIADPIVSARYVSVQKTNGILSLAEVMVVEIQDTSTVEGKVDFTLVANPARIGQTGDDAAVIQAYKGPNYASAGIIFGRQLTTGGSNVELPTGSMVVDDPQTICAVTLSSTLPESAGIDRTGVFYAQAVQNENVTRIQTIILNKDDGTVHTRPTQRTQIANIGESVVLQMENVNSSANSNYRWKHNGDDTARNSQLSVNISNAAVDDGGIYSCFVSGQESQQQHGFMRLIVRGCAAGMWGQDSCQNTCRRCYNGGICDDKTGTCICAPGFSGEYCQQVHGRHIFGQNASHTCSDSTDPHNDACRGRLFCLPDPYGCSCAAGYMGLDCMQECSEGKYGADCRQTCHCSSGDSCEKDTGECTGNCIPLYFGSNCQCSTDNGVLGLKVMPIDRYQLQVSWQPDPCVSGYILEYALTNRGQCEEIESPQWVSLPGPLDGQTTSHVITGLISSSTYMVYIRPLYNGTQGLEASTSGTTLKQENPSVSPVVVTSYDSARVTLSWREVYCANYFVQYALQNKEGCLPINPPTFIQHCLCSGTTSTKIPGLFANSMYEIQIFAKVNESSGETVTTSVHTSTKAPSAPPQQVTVTSTSKRSLTFSWSQPACGSRGGIITGYTYKLSGPGSRLIFNVFTAEQVEINGLIPFTNYSFQVAANTSAGAGPYSDVVNQRTNEAEPTVPLDVAIQNVDYVSITLQWSEPDPPQGIIIHYTVRYWRSGQSGKLTLINNVVQLMYEITGLETNETHFLQVQAETSVGAGPWSEKVFATTLIEAKKFEVPSQFAVIVPVVVVVVILALGLVVAFVVYKSSVNSNVNDGAAVSDKPHRHKSKSPRKPRQKQAGPEQSAEEGGNEQLEFVPPPSVRKEELAEYIRQKEAMGDNGFLADYKSLPDGQLYLWTVAAKPENRAKNRYVNVIAYDHSRVVLDPLEGDPHSDYINACYINGYKTKNKYVASQGANKASIKDIWRMVWQLGIDKIVMLTNPVENGKRKCLQYWADTGSTTISGIVVTTDKEDVFLDYTIRNFSIYQVGCAESNRSVKQFHYTTWPDMQPPEYPAPLLNFLRLVNGHHNPGRTMVHCSAGVGRTGTFIALDAMQQQMAQEGQVDVLGFIYQMRQNRIKMVQTPEQYKFIFDALLAASVTGDTTYSVADFRQKLTALKKKDKGAKETGLQKQFATLIQLSDRRGKVENMSGQLPENKDKNRYPDFIPSDRSRPYLFTSVQEDETNYINATFLPGYRKKSMYIGTQMPMPNTVTDFWRLMYDHKATSIVMLNTFDANDKTMCRYWPEEGTINFGKLSIELIQTKRSDSVTRCTFTLRNTDNASEEARTITQFQYHDWPSDQEIPNFVPGMLSLMDLARKWNGDKGPIVVHCMDGLGSTSVYCTLMALLEQFNVEKAVDVFQAAHRLRMVNQNMMNSLDQYALCYDVIQAMLDSTGIYEPITPSAGLDSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASQ7</accession>
    <name>A0A914ASQ7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066504.1">
        <property type="nucleotide sequence ID" value="XM_038210576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210576.1">
        <property type="protein sequence ID" value="XP_038066504.1"/>
        <property type="gene ID" value="LOC119736562"/>
    </dbReference>
    <dbReference type="GeneID" id="119736562"/>
    <dbReference type="OMA" id="EDSICNC"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="281" mass="30871" checksum="B182DDA8D0A97DC8" modified="2023-02-22" version="1">MANCQPLLFKFLKVYATMRNLGSKGKLETAAWDTLNKTLFIRELDVTKQGTISSVVDEILRENGRIDVLVNNAGFSGVDGIDMKSIEWCQSMMDTNYWGVVRTTRAVLPAMKKQKSGRILNVSSVTGILGTPFYATYASSKFAVEGFSESIAAVLRDGFNIRVSIVEPGPVTTDLMTNLVTNLEGHAAGFNDDKLKEMYLAQAKSMQPIVDRVAQNPDEIAKLHLKIILSDNPHLRYQTSPAMTTMVADKLKDPTTDALLDALKIPAKLDALLDALKVADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT78</accession>
    <name>A0A914AT78_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066556.1">
        <property type="nucleotide sequence ID" value="XM_038210628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT78"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210628.1">
        <property type="protein sequence ID" value="XP_038066556.1"/>
        <property type="gene ID" value="LOC119736613"/>
    </dbReference>
    <dbReference type="GeneID" id="119736613"/>
    <dbReference type="OMA" id="ICAAGWE"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 16 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="743"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for interaction with phosphotyrosine-binding proteins" evidence="18">
        <location>
            <position position="1015"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1037" mass="111653" checksum="23F71A9BD196394A" modified="2023-02-22" version="1">MVTPTPYGAGISQSSASISCFRSSPDADAALSFGRPFRIAVPESTIYASTTLPAGSREIVNASVGAITQDLTSSVDATGLFYCEGSNRGLTTRVYSIIHSVHRRLETVDGLVTKTVNKGENVTLTVTQVGSGGLPLWRRTRNGVLNYTYPDARQSSIKVPPRETVDGDLYTAVADPFDVSDNHFSMTRLIVRGCVAGKWGPPGCEKICNLCFNGGVCDDETGDCICPPGFSGPNCLTACGRHRFGWHCEHECGGPNDVIQSCSGSQFGLPDPYGNSCISGYSGRYCDTVCTSGSFGAGCTQTCHCQSGDCDPYTGECTNGCEFGWSGTSCQIPGDCPVGYYGVQCLSKCHCFDDEPCSRDSGLCSNGACALGLHCVSVPEACPAGFFGANCVRACHCLNTAACNENSQYCVGSDGECEPGFQSDVHINNCLFGITEFKVVAKTNPGQNVDFRCAASSFDTLPASSITLSTSPNGNGDTFRITSSATVNWVLVNTYSVPGLRTNESIYCILNYNMITTSMSLHVDFYALPQLSLPPSVTVASTSATCGCSEREGPGGEGPMCPATQFTLTLPELPPTLTTGGPAAMESATPSTQSTMESATSSTESTTRVKNLPPIAYTTSNIKAPTPPQPTPSGSSSIVLIVVIVVVVIVVIVVTVVSGICFLRHRRSRRKSAKTQSTGGQELVTYENEMFQPNDTSVTDYERVGHARPVSYDDVSVAPSPTYEDPGLPSWAQSWSIPLKNMIIGEKILGKGNFGEVRDGAVMVGGDISKAAIKTLKANASANDRLNFMEKFRTLTTVGQHPNVVSILGACQHEDNLYVAFEFMPNGDLRTYLRNARSLGDDDQSTLSSEKLIQFALDVAKGMQHLAALGIIHRDLAARNILLGSQLVAKVSDFGLSRGEDIYVQTSRTPVPTRWLSLESLTSKINTLKSDVWSFGILLWEIATLGATPYEDIKSKNLLSRLENGYRMSRPSNCDDEIYNLMLLCWQDDPANRPHFKKLVTRLTSMADSQNEHMYMRLLPKAENYMYLMIRPELDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATV5</accession>
    <name>A0A914ATV5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038067103.1">
        <property type="nucleotide sequence ID" value="XM_038211175.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211175.1">
        <property type="protein sequence ID" value="XP_038067103.1"/>
        <property type="gene ID" value="LOC119737081"/>
    </dbReference>
    <dbReference type="GeneID" id="119737081"/>
    <dbReference type="OMA" id="GEEVIWC"/>
    <dbReference type="OrthoDB" id="1866797at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056602">
        <property type="entry name" value="Beta-prop_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23748">
        <property type="entry name" value="Beta-prop_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="16">
        <location>
            <begin position="636"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1305"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1906"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1312"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1906"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1939"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1970"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2119" mass="239659" checksum="B31A0B0FA07737F6" modified="2023-02-22" version="1">MATDDGFSTDMTEVLAEALLDNLRQKPTSEVARFLQTFSEDARRHLFRFTEGNENRHSFPYPFLQVACQYAKIDAVLMLLSYGADPSLRTEKEGTALEVASRHGRLDMIKKLIEWEPKLIEDRDIVKDLLAIACFAGHQDITEFWLTKLKAMKNGEAICKDDFVGTNDPLIAACRGEHYGLAIHLLETQVTVITRETALRTGLKFNPILQMWCEKETDETQENERCDAKWSGRHLHYFDAAWLTRNPDLKRTLVRINLSHNALSSIPAVLLWELPCLESLDVSHNNLAELPGPETLEVLKETRLTNLKVSHNILQFPVLEIFMHPVLETLDLSHNKITSLNHKRFPSELVLPAEDEKVWKCSNLMSLNVSSNSILRIPQYINAAKNLKKLNVSHNRLNKLPAPWDCPLATFNAAHNFITDVPDMHGYWSRSLTNLDFSYNMLPEIPWTICQLTALNCLKLTNNHISKLPDPESWSIYSLRDLILSCNRLVFVENTAPASPKRKSSNLSAKLNFKRDSGVSSTTFYSDSSSAGSDSATTIVFPECFSDCLMTLDLKNNRLRDVPPSLSNLSYLQKLDLSGNTGIEKLPDTMAKLKNLYSLNLSGLKIKEPASVVSIMQEKEHKTRKILEKLNERFLKCSPYRGMKLMLVGPEKCGKTSVLSCLTKREPDDDLGVNICSWTLQDPARLVVKPSLKKKLFHPKPDQSTSGQNDVHFSAWDLKGGEMNSIIHQSFFTARALYLLVWDLRDRLDGVEKLRPWLLNIQSRAPESAIIIVSTHLDKGRKSQSLDSIREEIRSKYSCRDGFPDIAEIVEVTGTTPEGEGIKELRHAIYKTALGMRIKKRWGSGAVTSTSLIGQMIPRTFTILQEIIASGADRCKRSIPPLPPIMKDAELTSHIKKIPDNKIETGQDIEEAAEFLSISGTLVHFSDHLQGLTSLYFLDPVWLYDILSNVANINSSYVKEGRIHRSSLEEQFKKSGFGEGRFEEYQQLLQRLEIVLPISRIEYLIPSRLPKEKPGQDFSPVLEDGGNTFQVLERLYKLPYTPPGFWSRLVSRVYVFLKFLGENGGRKVKAIAKRDLRRGVQIKRSSRLRQSMRVGLKLSRTNIMYWQQGVSVQHNTGQILLKPITFLGDKPGICVRISCHIGEFQPMGFMVDQIENLIKEWYPGLLGVDEFTGKPLIERLVPCPVCRKLSVQTERPLAMTHNLESDEVCHHFSVSKLALSATMKGMEHAECPRHQEGLKLRKLIPDLYLIDLPVGMLNKKDFDFDPRVSPSLGSGGYGEVFKAQFRREDVAVKMLIKSTFFNSRTDSGLHSSADEDSKKSSAGSDRSDSGKQSVSPKSYDENNADVNAIFVMEGFSNLRGEVATMSKLRHPCIIHLIGISIQHLCFAMELAPLGDLASLLKREMEAQRGFFTINSKIYRTILDRVLTFKIAMQIARGVSYLHKQRVIYSDLKTDNVLLYSMDVEAPVNIKLTDYGIARSMDLQGARGQAGPTGFCAPEIQRGRTFTEKVDWFSYGMLIYHLMSGAWPYDNLKSAVEVRNAVNMGIKPGFQFRDYTIVSLFPNLERLMMKCWQDNPLKRPNGEDIAGMMQDASFTCLRNVLRFDMEEITCIHPGASEISYVDDEMELVAKDTDTNLEDHLKAGEDEKQKRCHSPRVRKQFNRNCERLWLWTGEGGSRRCTKIHIRFFNEGELYPKSIVGSRANCLVQVGLWELVGTKDNSIQLFGPPDVGPQHIVHQHDFQLDAEVVCLCYQPIKDKTIQGHLFAGLADGHLVIFNHAAPETNRTSVGSRSSTHEPCWFKTKTLTFENKRCSHLELVVEREELWIACGTKLRVLSTEIMLLDAAITVTSRAEHTILGLAHHHDNLFCIIDRSSRVLQYSMATRQLVQILQCGRFELEKGVSLIADEEEEVGEVEEVEEDSKSSPSSDSSEDKEMSFRDSYYSTPEQQMQPSSTLPAPPKRTITASCKHPGNSRDDAGLHRPFSEGSDRRRCSVSIPEVQAILTVKDTLWIGTTHGDIIIMCVDPNNRQGFKFGEVLAVMGLFLEKDDKKQPIKQLMRAGEEHVVAWQELKLSSPGSLVSDTREDKLHHYQLLVWQAWGSEDVGKFDHIHTMLNGAEQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATZ9</accession>
    <name>A0A914ATZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
            <ecNumber evidence="5 13">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_038066969.1">
        <property type="nucleotide sequence ID" value="XM_038211041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211041.1">
        <property type="protein sequence ID" value="XP_038066969.1"/>
        <property type="gene ID" value="LOC119736996"/>
    </dbReference>
    <dbReference type="GeneID" id="119736996"/>
    <dbReference type="OMA" id="GTHGVQS"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037249049" description="Alpha-amylase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="401"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="491" mass="55336" checksum="A9FC66754B1ED07C" modified="2023-02-22" version="1">MAIIWVFCLFLGVAVAQWDAHTMDNRQVIVHLFEWKWKDIANECENWLGPHGFAGVQVSPPNENIKLEPERHWYERYQPIGYGLDTRSGNENEFKDMVNRCFKVGVRIYVDAVINHMAANTPDGSGPYDFWRVPYSELDFNYPQGKCPTPSGIDYSNVDSIRNCDLKGLKDLDLGKDYVRGKIAEYLNRLIDMGVAGFRFDAAKHMWPGDLQPIYNRLKNLNTNFGFPSNARPFVVQEVIDQGGEAVSAWEYLNIGRVTEFNYGIKLAEGFYKKNPLKSFQNFGEAWGFIPDYNSLVFVDNHDNQRGHGGGGGIITHKDSRRYKMANAFMLAHPYGLTRVMSSFAFSDPNSSPPKDAAGNIISPIFYADNTCGNGWVCEHRWRQIKNMVDFRRVTVSQAFANWWDNGFYQIAFGRGNKGFIVINNEDFSLSQTLQTGLPSGTYCNIILGDFNNGKCTGPTVYVDSNGFAKFDIAGSGNDDPVVAIHVGAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV20</accession>
    <name>A0A914AV20_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RBR-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067939.1">
        <property type="nucleotide sequence ID" value="XM_038212011.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067940.1">
        <property type="nucleotide sequence ID" value="XM_038212012.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212011.1">
        <property type="protein sequence ID" value="XP_038067939.1"/>
        <property type="gene ID" value="LOC119737561"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212012.1">
        <property type="protein sequence ID" value="XP_038067940.1"/>
        <property type="gene ID" value="LOC119737561"/>
    </dbReference>
    <dbReference type="GeneID" id="119737561"/>
    <dbReference type="OMA" id="CEIHYKE"/>
    <dbReference type="OrthoDB" id="9978677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19815">
        <property type="entry name" value="Bbox1_HOIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047543">
        <property type="entry name" value="Bbox1_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047542">
        <property type="entry name" value="Rcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032065">
        <property type="entry name" value="RNF31-UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041031">
        <property type="entry name" value="RNF31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057426">
        <property type="entry name" value="RNF31_UBA_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LUBEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18091">
        <property type="entry name" value="E3_UbLigase_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16678">
        <property type="entry name" value="UBA_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25163">
        <property type="entry name" value="UBA_RNF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1278"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1656" mass="183536" checksum="426B94EB23D57952" modified="2023-02-22" version="1">MENPSAAECYLPDTYQPPSKVDETNLDSGAFQHVKDLHVQVENYMKALPVNEKSIAEHVDQIVALDFPLPAKFSKVNVVDLIKKNKNIKADDSLPTLASALGLLEKYGRNLLKPERPQLWKCIYFANSVFRMRVDIIKGARDVLKLMGYSEVVEDGLSFPTDQESPSLDLVAIVTADLAIAKREIELFSQGEHPYSYRIQDCLDGTIAMIQFPPDSPSGQPKNIFMRRPAQGGKTIYENVTLMQPPHKVDFSERFNQQLNLGSTTDGNWRDALEVVPALAPVKINPFASSLQPASQGEGIIRRIGDPMPASGPAKSDVGLGYFANTSGQVAQVPNVAPSTAHQSVVVPSQTVSQVPAINTEKTSECVMCGKATAKLQCSTCSGLRCESCDKQWHLHPNRRAHQRKMIDLPPVIEVTTSQPLPPIVLCDVCGTQPASLFCVNCSSSTDSGRYCSDCDAVFHGHPLRQDHSRQPLELTKTDPADKPPPKNIVLSPVSSQDSSQPTESGPALAKKRPIPAPRRSFNKNQARKEPSEAAIPEGTTLSDDVFTVDESKWIQPDIKHPPSTQRTTTRSQSETDLEHTASGPVSPKAYHSLPASKKEIMSEMEAVVKMDIEILQKIQADRDIMSTCDKGSPRYETLQAEISRLTSEHEGLLRRQKELEALEKSATLGVVAEKETTEEHPEVRYPPAKDYKSFPSRQTTMAATTPKGSPPTNTTASSNAPRPQPRSVSTSESLRQTNQVTNTQPASAGIPYTYQEPFAPPNQGSQFLPASASSAPSVAVRNPPEITPSAQPAVMDVGSPIVQPGRVQQLVKHSSSGSTVRGAPNSTSQAPINGSQSAYGAWVCQSCGNHNTASSSNAVCMTCLSPLSTTQRQTVAALSQQLSHTLPMAAPPRQPQPGTFQMKAASTAQAATAWAEEPVTAAGATPVPSRSLPSQPFKPVSVFTYLQMEEEAMLKEKQKAKEEYEMQMAAQREEKPKTPSPPPRTKKAHKKEQELPSERAPMSPRMKLSPNQDDVLLTPLAKDFTAAPRSVSPGRSHVMSLEDKKRLDEQRSQSLDLIEILRAAEGAGYFPEEVVAASEQMQGSNSEATNELQWLEENWDNYVSTVTTMATNHLKKEIGKSFSKVRSQDASQALRKHYGNVEKAVEECVTEIQKRVLSLVDLGFSHKRVCELLSTCDGGVDEVLIKLHQERAAEFVARIWAAENSASQKKQVVDLGVCRDNESKERRLRILLAEYDLSSWGRAETAATLIDRNKYDFDDAITAAGQCGDLERAKQYLEKECQVCFAEFPMNKLSTLSHCQCLICSGCLEGYFNEIITNRNIMKAACPVCDKPDLRRNDPEVTDYFGFLDSLLKGILDAQSYQLFQTKMRDWNLMKENNFRWCANCGNGFINEAPGRRKMRCHECNQITCFECKKPWMDQHENTTCAEFQAWKEANDPNSQAEGLAIHLKENGIDCPKCKMRYELAKGGCMHFKCVQCTFEFCCGCGSLFNKGNECRRFASCLNRGLHAHHPRDCLFYLRDQDIEALQKLLQKHNVEYKRNNPQANQQQVCSVKEQKELPDGLEDAECGREVVQQTGLCSVHYKEYLVSMINQSHIDPADEYNIADLTIILKRNEIAVPARANKESEGAYRTRILKEVKEKLPLERKNPRDRAQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW78</accession>
    <name>A0A914AW78_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068355.1">
        <property type="nucleotide sequence ID" value="XM_038212427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW78"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212427.1">
        <property type="protein sequence ID" value="XP_038068355.1"/>
        <property type="gene ID" value="LOC119737812"/>
    </dbReference>
    <dbReference type="GeneID" id="119737812"/>
    <dbReference type="CTD" id="7385"/>
    <dbReference type="OMA" id="APKFALY"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="458" mass="49396" checksum="DE9FD2ECB0C61CD6" modified="2023-02-22" version="1">MMSLSGLRPVFAGLSRRLYAAQVATATQSADKAPLPQESVQVSKLNNGLTVASLENHSPVSRIGLMVNAGSRYETSQNLGVTHCLRSYANLTTSNATTFKITRGLDEIGASFEATTTRDLMIYSMQCLRTHLDEAASYLQAATTGQQFRPWEIKDNRQRLFFDLASVRDQLQIEVLENLHAAAFRTTLGRSLYAPEYMVGKIGSEMLLEYVNNMYTAENMALVGVGVDHGDLKAFGEKFDVKRGFKTVAPAANYAGGEIRSQRDSPYSYVAVGVQGAALSSKELLTLGVLQQLMGAGPYIKRGSQLASSKLSQAASKATTVPFSANCFNMSYTDSGLFGMFAVTHAEQMGAMLKSMMGQMGAVTKGNIDDKDLSRAKNQLKASILMSLENQSTVFEDIGVQALCTGDYVSPAAMMAEVDAITGQDALKVAKRIFNGKLSMAASGDLDNTPYLDQLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX89</accession>
    <name>A0A914AX89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068750.1">
        <property type="nucleotide sequence ID" value="XM_038212822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212822.1">
        <property type="protein sequence ID" value="XP_038068750.1"/>
        <property type="gene ID" value="LOC119738088"/>
    </dbReference>
    <dbReference type="GeneID" id="119738088"/>
    <dbReference type="OMA" id="WQSANDY"/>
    <dbReference type="OrthoDB" id="6038967at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32509" checksum="FC9E9A80E155E3C0" modified="2023-02-22" version="1">MCGRECSMDMHCMSFNFDEGTNLCEINQATRNEHPGNFSATLGSLYYDGDEETPLYSLSDCCLNRYRSCKMLLDAGCRSSGVYTINPEGFGNGGLRVYCDMETDGGGWIVFQRRQDGSLDFWRNWAAYQSGFGNLSGEFWLGNDNLATLTADDSQGTWELRVDLEDWDNKTAWARYTDFKLSLGKYNLSYDKYDSKSTAGDSLEYSKGFPFSALDADNDNWPYNCARYHRGAWWFNSCFMSHLNGQYYPSQHANDDMGISWYTWHLFPYSLKTCGMKIRETGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZP1</accession>
    <name>A0A914AZP1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-fucose kinase</fullName>
            <ecNumber evidence="8">2.7.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13241"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57268"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.52" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038068725.1">
        <property type="nucleotide sequence ID" value="XM_038212797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068726.1">
        <property type="nucleotide sequence ID" value="XM_038212798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZP1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212797.1">
        <property type="protein sequence ID" value="XP_038068725.1"/>
        <property type="gene ID" value="LOC119738071"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212798.1">
        <property type="protein sequence ID" value="XP_038068726.1"/>
        <property type="gene ID" value="LOC119738071"/>
    </dbReference>
    <dbReference type="GeneID" id="119738071"/>
    <dbReference type="CTD" id="197258"/>
    <dbReference type="OMA" id="QRWREAW"/>
    <dbReference type="OrthoDB" id="271303at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.120:FF:000001">
        <property type="entry name" value="L-fucose kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="11">
        <location>
            <begin position="83"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="10">
        <location>
            <begin position="844"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1101" mass="121219" checksum="641CACE9D9A350E9" modified="2023-02-22" version="1">MMGKQRTKWTAIIVTCTDEASVQPLQYELEVRQKKGYIDKDVLLLTVEDPQVRVGSGGATLNALLVVSEHLSQRHGYTVVNSDVLLDSYILILHVGRSFLFDSCGRAFVSLPAKHESGTKAGYEGVVTNMDHLIHTVTYKLSAGCPPGVWVCSTDMFLTVPTTPKMDWTGFDGACVVSVPATQEYARNNGIYRINQEGYVLDIFFRGGPTAMKMCSLHDGTGDASDGMVSLVAGIVFLSSRAAEKFLFLHVLPGLDACTYMGLDSGVKPLELSLFFDVLLCLAKDVTKEEFVSGEKGIPYDKMRHKRACEQGIVRNARAQMWEKLRGIPMKAMLVPDGNHQYLTTSPREHLKRAISCPLYSDEDEHFNWANITHAFIQETCSVEESAVVTNAILEGDVTIGAQCAISHSHLQGEIQIPKESILVNIDCKASKALQQHSLSPGIFLQAFRLRLGGSQKLKCEVYTVMGRFDQLETAYVKGTSTFCNSPWIVFLTRTGIDREDLWPTNQTDYDRTLFNAKLFPVWNLQQDIGIAETLWLEGGEQDMDMLTRWRSSWRLSFEDILSCIDLSAELSRRRDLFYSGGQRRVRDVLLRGGNQVLMPFFKSATVEGYAQQLLENIDQGICDSNSPSIAARGLAFIANILGAMAGGKGGLRSGPAANAAWQSAFKLLEEGKLHEGVKALARERQQWLNRPDRLVRAARHYEGADQIFIRLAVMSAREYIFTSPGESPPMNKWVTATCPGRMDVAGGWSDTPPITYEHGGAVVDAAIRLDGKKPIGARARKITEPHLVLVLGSDQEHSVQIVCKELSDVADYNNPQSSGALLKAVVHCAEVISLPSSQSLQEQLMSKYGGGIELNTWSDLPQGSGLGTSSILAGAAIAVLWRVSGQAYDHSSLIHAVLLVEQMLTTGGGWQDQVGGLTPGINIGHSEAKLPLKVEITPIPVDEETRCKFDQHFLLVYTGKTRLARNLLQDVVRNWYARSPYIVENCDNLTKNAWECKKAFAEGDLEKVGVCMNAYWTQKKVMAPGCEPVMVQRMMTALRPHVHGQCLAGAGGGGFMYVLTKEPNAIGQVREILGSEEGVEDFTVHSVQLDQAGIEVEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1B4</accession>
    <name>A0A914B1B4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069782.1">
        <property type="nucleotide sequence ID" value="XM_038213854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213854.1">
        <property type="protein sequence ID" value="XP_038069782.1"/>
        <property type="gene ID" value="LOC119738879"/>
    </dbReference>
    <dbReference type="GeneID" id="119738879"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926340" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="154" mass="16971" checksum="47148E19FB42DFC1" modified="2023-02-22" version="1">MKAYICLVVLVCLGSVLSAKTNEADEVVVKQYLGAPCGFDSPPCDPGLTCMPWGRCEFTRKRMANVEADEVVVKQYLGAPCGFDSPPCDPGLTCMPWGRCEFTRKRMANVEADEVAVKQYPGAPCGFDYPMCDPGLTCMPWGKCDFARKRMAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1P9</accession>
    <name>A0A914B1P9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069833.1">
        <property type="nucleotide sequence ID" value="XM_038213905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213905.1">
        <property type="protein sequence ID" value="XP_038069833.1"/>
        <property type="gene ID" value="LOC119739070"/>
    </dbReference>
    <dbReference type="GeneID" id="119739070"/>
    <dbReference type="OMA" id="LQLIHKP"/>
    <dbReference type="OrthoDB" id="5976674at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="195" mass="22756" checksum="B87CE68375176ACC" modified="2023-02-22" version="1">MANDPYSSAEPGKKWDETADATELQGLSGRRCREKTSLLLTYYKKEDAEALKRSGTEEEMEEKHQLLQEIKELQEEQVTRLESENKKKEKQRKIAVEIRKAALETLPKKRTSDESQISDSDSDNNATPRKARRSSSSSDLMMFLKSKAEKEMSLKEQEIKLKSEQLAFEKEKFELERKEREKKMEAESEERKMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B233</accession>
    <name>A0A914B233_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069849.1">
        <property type="nucleotide sequence ID" value="XM_038213921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B233"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213921.1">
        <property type="protein sequence ID" value="XP_038069849.1"/>
        <property type="gene ID" value="LOC119739087"/>
    </dbReference>
    <dbReference type="GeneID" id="119739087"/>
    <dbReference type="OMA" id="VINIYLC"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="395" mass="44736" checksum="9BA4642CE66E1E98" modified="2023-02-22" version="1">METTVSLSFSELQSSNNESLLEEGRSCALEATVVLDATRIEFIDSMLLYSRLQIVYIFVVIPIITSLAVITNGSYLFVVAKTKSMHTVINIYLCNLAVADVLFLLSSCGIYIYYYFISGGVYANLPNAGTLDCNSSQFANIFYVTSAILIVAVTLDRYYAVCYPLKHRMFSKTRAIKITIAAWVFAVLYRVKDVLVFWYKTRVCVIWPDLPRYSELSPVLGYCDTIFTEEVRILVVHFFDPLLFVLMMLANSFMYFKIVKALKNRPAQRDGQQGLSDSADRTRRSVTRMLLANSIVFFILTAPEFIQKSLHGLQKFKVELPPALTNVVGSHVTSITTNILVNINSMVNPIIYNVANSRYRQAYREAFLPCRQTADRQRRKQLSGNIVATNMTVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2M8</accession>
    <name>A0A914B2M8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070053.1">
        <property type="nucleotide sequence ID" value="XM_038214125.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070054.1">
        <property type="nucleotide sequence ID" value="XM_038214126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2M8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214125.1">
        <property type="protein sequence ID" value="XP_038070053.1"/>
        <property type="gene ID" value="LOC119739265"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214126.1">
        <property type="protein sequence ID" value="XP_038070054.1"/>
        <property type="gene ID" value="LOC119739265"/>
    </dbReference>
    <dbReference type="GeneID" id="119739265"/>
    <dbReference type="CTD" id="9688"/>
    <dbReference type="OMA" id="RPHAVHM"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="827" mass="94248" checksum="B245809FFE1DC811" modified="2023-02-22" version="1">MEVDSFDDLLRDAEQLTANVDSGGELPRVERNLHQIMETSQRLWTKTAQVGVPDAADVKASILLGSKGLDVPRISQRLETLSATKTFEPLEPIADTDIQSFLRNERENAVLAVIQETKKNTLQQTEKRFWETMQSEWQEQRQRILNALISSGEDLLDIGPDTESMLSETVAMDGRSTMDSVEMAYARQVYLYNDRVVHGGVRPNLIQLFEQISLQFEDKRVSELWAMVREMTSVPLISTVDTVQARSAQEMQMAFVRQARSYLENSYLKYISTIVGENLQRAQVGGIPGTFHRVQGFMKVKLPHPVPGLEDGEVNGQPVWPIIYYCLRCGDLDAVLHAVQRAAQDLGEFEEYLKEYMDSEDRRLSPNMQTKLRIHYRSNVRNSPDPYKRAVYCLIGCCDTTDSHSEVISKTEDYLWLKLSQVSFVEESGPSSLDRLTLPQLQTTLLEEYGENHFSAHQNPYLYFQVLFLSAQFEAAIEFLSRSDLRLRCHAVHTAIVLYEMGLLVLPANIQTQVLSKHLDDPSPMRRLNFARLISMYTSKFENTDPREALQYFYLLRGLKDHQGENLFITCLSEMVIETREFETLLGKLGQDGTRRPGAVDKFQANTQRILETVARDTEAKGLFEDAVKLYDLARNADKVLEILNRLLSPIVAVPKSGQSNRQRLQALAVAIAGRFQSQAVTGNQSNTKSFYLLLDLMTFFDEYHGRELDRALETIKTLQLVPLTPETVDDKVNAFKQYTDEVRRNMPDILLATMNILHTKYRNTRNTTLQNAQGRPTARSEDGGKESYLADLRRQAKSLITFAGMLPYRMPGDTNARLVQMEVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2N5</accession>
    <name>A0A914B2N5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070173.1">
        <property type="nucleotide sequence ID" value="XM_038214245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2N5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214245.1">
        <property type="protein sequence ID" value="XP_038070173.1"/>
        <property type="gene ID" value="LOC119739347"/>
    </dbReference>
    <dbReference type="GeneID" id="119739347"/>
    <dbReference type="OMA" id="DISVWVS"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="207" mass="23470" checksum="119CEDDC3DF4A71C" modified="2023-02-22" version="1">MMPTYRLIYFNNRGRAEATRLLFKLAGQEFEDVRIPGEDWAAQKSKYPLQQLPVLDIDGKLIPQSRAIASYVAREFRFHGSDSWQTLMIDVVCDTADDLTRPLGDAIFLEKDETKKAAAIKNYYENEAPVVLDCLEKYLVSNGGGDGYFVGEKISLADISVWVSLDLCFSQRKDILANYPKLAKLSDRVTSRPIIAAYLAQRPQMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6V3</accession>
    <name>A0A914B6V3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071936.1">
        <property type="nucleotide sequence ID" value="XM_038216008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6V3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216008.1">
        <property type="protein sequence ID" value="XP_038071936.1"/>
        <property type="gene ID" value="LOC119740643"/>
    </dbReference>
    <dbReference type="GeneID" id="119740643"/>
    <dbReference type="OMA" id="GTREEKC"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="42997" checksum="AD9C1BAEE637B6EF" modified="2023-02-22" version="1">MDVTTSTVVIEGATLDPTESSTYEFSDYTQRVIVATMILVIALLGIFGNTLVILAVLLSNKVRTATNAFVVNLSVADFLTCLVIPWNAVALLGREGLPVGVWVCSIIAVVQNATIGCSIFSLVAIALNRLLLITRPATTYHKVYTPKKIVIWLVLVWLVSLFISTLIPSFINISGFTYNKKYHTCGSTTSQASSRTYNTIVGGIIYPILLIIIIVCYVLIWRHLKRHYRRMATVHQEARQLTPSSIPTTTTVTISPAHMTSDDRIQSPATPSSVPAINSQVTRRQNDITKNMFYVVCAFMLCITPYAVVVMCGDSPARPYLFVLFIFNSCVNPVIYATKHRDFKTIFGCILRRNLAAVPEPSEFLKFLQRNMCCGTTEHRAVNINRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B703</accession>
    <name>A0A914B703_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071986.1">
        <property type="nucleotide sequence ID" value="XM_038216058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B703"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216058.1">
        <property type="protein sequence ID" value="XP_038071986.1"/>
        <property type="gene ID" value="LOC119740683"/>
    </dbReference>
    <dbReference type="GeneID" id="119740683"/>
    <dbReference type="OMA" id="PRTHCST"/>
    <dbReference type="OrthoDB" id="6340082at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="139" mass="15551" checksum="737B6AA45F8046C8" modified="2023-02-22" version="1">MGWILLPHHPKPLTYDDAREACRGLGAKMAAPRSDQENDFLASLAQGSKIWVACTDRRQEGEWKCDEGSQDGQGIYINWMGDQPDNAGGNEHCATIWSPDKKWNDYRCNGEQLAVCKQQPRTHCSTTNSEGRLEADSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8S9</accession>
    <name>A0A914B8S9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072394.1">
        <property type="nucleotide sequence ID" value="XM_038216466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216466.1">
        <property type="protein sequence ID" value="XP_038072394.1"/>
        <property type="gene ID" value="LOC119740950"/>
    </dbReference>
    <dbReference type="GeneID" id="119740950"/>
    <dbReference type="OMA" id="MHERQEL"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="11">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="107" mass="11636" checksum="99158248A2457D4B" modified="2023-02-22" version="1">MSKDATKGFVDAAIADNKVVVFSKTYCPYCKKAKSALNDVGLKGYKIIEIENMDNMDAIQDYMLQLTKGRSVPRVFIGGKFVGGGDEVAQLKSQGKLKPMLQEVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9L3</accession>
    <name>A0A914B9L3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072132.1">
        <property type="nucleotide sequence ID" value="XM_038216204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9L3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216204.1">
        <property type="protein sequence ID" value="XP_038072132.1"/>
        <property type="gene ID" value="LOC119740783"/>
    </dbReference>
    <dbReference type="GeneID" id="119740783"/>
    <dbReference type="OMA" id="CKEIDAC"/>
    <dbReference type="OrthoDB" id="9888558at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23539">
        <property type="entry name" value="TFP_LU_ECD_CinHb4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037265215" evidence="4">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="284" mass="30238" checksum="774B345813D8E911" modified="2023-02-22" version="1">MPNSMNSKLGLVIVMIVASKIRCGNAISCYVCDSNNNDCNPGTATTCGSGQICMNEVRDENSLFIVRKVCKEIDACHTQENQNPSQCHRGENVNSVCYYCCDTNLCNSGDYLDVTTVAASTTHGTTQSLPDPTTLPVTTAPPDPTTLPVTTAPPDPTKQAMTAAPIDPTPSAHFSAVDQDTTTTHVAQSTSTVTPSQASSCSSDWRSQSSYFVVTDLHHTIHSSEMIIKTPARSRLACSLMCIHQSGCGFFAFNGETLACSLGGGIYESSKVQAQDGSTVFQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAD7</accession>
    <name>A0A914BAD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038072800.1">
        <property type="nucleotide sequence ID" value="XM_038216872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216872.1">
        <property type="protein sequence ID" value="XP_038072800.1"/>
        <property type="gene ID" value="LOC119741166"/>
    </dbReference>
    <dbReference type="GeneID" id="119741166"/>
    <dbReference type="OMA" id="IVCSIRH"/>
    <dbReference type="OrthoDB" id="10057603at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF562">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340461" description="protein-tyrosine-phosphatase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="552"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="740"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="846" mass="92526" checksum="C0E9F489C72EE64F" modified="2023-02-22" version="1">MVKSRRRWSFRLRFAVQWYLVCCVILGHKIGLSAPADDSQPEIPTTKDPHKVTEGPGLNTPNNQPGVTDEPPPPDKTTARPPRLTTARGEPVVTAGSGFTTGGGVVEPKVTTSVVTHAGSTQVPELTTLPSVTTVSLVPTTPVPVATTPGMTTGPATTGTSPSITTVTVAPPTTPTIPGVATTRSLRTTTRAHTTEAVTTSQPHLTTHNPPPPITEPHRPSTRHPPIIPTEHQPTEEPPPPHTQGPPPETEPPPPTKPHKPTRPHPTNPPPPTTKAGSRPTNRPTARVTGSTPTSFPKTPIPYPSVAIQLVLQETWKDFCPGIKQFLSSIAEYSKMALSLSHSPYIALLNDTKSCFEAETNLQDTPFNEIRVQVDICIQTKEGSCDTNLTESVGVAMQSNQEELQRYLIPTVLSVRVYKPLQGTPGPRPTKSATGVAVGLSFGFLIMASVISIGAFKINKSRLAKRRALNNRYYFDGKELHDTFSESHQLSPVHHTAAFTMPATITITHRLVPAINKGLIMDDEEDVVAVKYPSHVLSMHGLSQFYSYLEAITEEFETLLDFQKDLSKPHSPSKTSSLSPIKTSTLSPGLFHPPPRTRVPLEKSSSDNQHGFLNASFVKGYGNTTYSYIATTNPWGTNLNDFWEMIWEQQSRTIVCLCSPEEMGVVCPWYWPRDEGIQNAQLYGDILVMRQGCVLTENYSMSTLLIKNIQKNLCRPINHFWFTQWPVVCNQVPSSPTLLLSFLLQVRQTVQDSYGPIVAHCSDGCGRTGTLLAIDSGMRSMEDLCTVDVPSIVCSIRHDRGAAVLQKEHYVFIYKTLFEYSVMLTRGLADGMAAEVDGIDTDASLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB25</accession>
    <name>A0A914BB25_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073224.1">
        <property type="nucleotide sequence ID" value="XM_038217296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB25"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217296.1">
        <property type="protein sequence ID" value="XP_038073224.1"/>
        <property type="gene ID" value="LOC119741513"/>
    </dbReference>
    <dbReference type="GeneID" id="119741513"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037746709" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="518"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="803" mass="89872" checksum="52BEF27C048BB7BB" modified="2023-02-22" version="1">MLRDCFLVALLLMAGSVLTEGTLGYYEGGTVFWEARNPDNPREITVDFELNFDARRNSGTHHQCTEESIRTHKKLRTGGQFIVGNDKMFADYYCVKLDPVKQTATGYYNLTYTLPPGESTAQISYTECCWIDGIGNNGGDIGTGKGWNLASTINIAHKDGVSINSPPQSKTFAKYAIMSGCTYSMRIANDDANNDVVKCRWASKKKNECNVNALDICGVTYFDEGRKKPVASLDKESCDLTFGEEETIPPGTYAFMVMLEDFAPNKLKKPMSKTPVHFLMDVFHYEGDCRQPQLHVPRMCFAHVLGEEFQMRIVATATAPNYRITSIDVQGYPTDAPSKVSGTDSDYDIIFTFMPRKLKTYTICVLAYEDERFISSQSCFTVNVVQTEPPALRVDQANSIPAKGDQEAEAIVPNWAIKFDRTIRKGVFSPAYVTLRDSNNDVVWRVDATGPDAEIVGETLTFPNSQDVYLEYEAEYTISLDEGVVQSNDKKCSVKSKPSEWSFVTGVPEPTFVILKPVCSVSSMTMFLPKLLLDLGDYGPEIMHLRDPQCQGVNFNDTHYYVWTSYGLCGTTFQRNGTDYMYSNTIYIPEAPYSPAGTKVTRVPHREIHFSCSIPAKTTKTLTFDPSPGTIGHEEFNGRADFLDNLADTTLKLFNANYDQAYGELSKPLKVPFDTRLYFEGEASCDNRQCDAFFQSCWATTSENPYNWPRHELIKGGCIQDNTLTVHETGVSNKVRFSVDAFAFLGWRIRDTVYVHCNVFVCSSSDNSSICKQGCLQTRAMTSDGVSRRDFMSVVSSPGLIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB73</accession>
    <name>A0A914BB73_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073458.1">
        <property type="nucleotide sequence ID" value="XM_038217530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217530.1">
        <property type="protein sequence ID" value="XP_038073458.1"/>
        <property type="gene ID" value="LOC119741683"/>
    </dbReference>
    <dbReference type="GeneID" id="119741683"/>
    <dbReference type="OMA" id="YAGPRNA"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44234" checksum="6091CE599CE470AE" modified="2023-02-22" version="1">MAPNHKLSEASVDEEYLTGKNYPAKDGRFWLWFLVGTLLNVCIIAASVGLTVMYVHTELQSLKDQMQIHEERLAWLESDSSKQDAGGKDVPTWKYAQLRTRRDRQPQVSSGRSGQRNETHLPGYAGPRNAGAALCRDGRDGRDGKDGQDGAQGPAGPAGPTGIKGEKGDPGIDTDRGSSEMMLHRRAKRDLGDGNSSHTAENRESGAHDVYPTLRPSGGETYVRWGRTTCPSDINTELVYAGIAAGAHYSHKGGSVDFFCLPSEPEWSASHNDGLNSNSFLYGMEYEVSAFDPFSHENAEFLHNRDVPCAVCRLTDRGTQHLFPAKLGCPENWTEEYRGFLMSGHHGHEQRSKAMCVDEAPEAIPGSQTNQDGALLYIIEGRCGSLLCPPYVEGREITCTVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH28</accession>
    <name>A0A914BH28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKI-interacting protein SKIP SNW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075195.1">
        <property type="nucleotide sequence ID" value="XM_038219267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219267.1">
        <property type="protein sequence ID" value="XP_038075195.1"/>
        <property type="gene ID" value="LOC119742976"/>
    </dbReference>
    <dbReference type="GeneID" id="119742976"/>
    <dbReference type="CTD" id="22938"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="171"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="536" mass="60887" checksum="9000705675D79794" modified="2023-02-22" version="1">MVSLADILPAPKQWGQEEFESDRPRQLSVVSLARSTAPPYGRRKGWVPRTPMDFGDGGAYPEIPVAQFPMDMGRKPGKGNAIAKSVDAEGRVKYDALARLGHGKDKVVHSKPQDLVPTQITNENDPDVQKPDEEEIEDTTEKTRQALEKLVQSKISAAMPVRCAEEKAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEVQKDPIEPPKFRTNKKIPRGPPSPPAPVMHSPTRKVTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQNPQINENFAKLAEALYIADRKAREAVEMRATMERKLATKEKEKHEENLRNLAQKAREDRAGIRTQAEADDEARERDKIRDERHRERQRDRNISRAAPDRRAKFDKQKERDISEKIALGLPNAGGRADDMQHDHRLYNTSKGISSGFAGGEDESYNVYSEPWRKDQNVSSSLYRPSKNADKDVYGDDLDTLIKQKRFVPDKDFSGTDRSRRRDGPVQFEREEEEDPFGLDKFLKDAKKAGKRPAEGGKSRDHDDHDRSGKRRKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH92</accession>
    <name>A0A914BH92_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075459.1">
        <property type="nucleotide sequence ID" value="XM_038219531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219531.1">
        <property type="protein sequence ID" value="XP_038075459.1"/>
        <property type="gene ID" value="LOC119743158"/>
    </dbReference>
    <dbReference type="GeneID" id="119743158"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="231" mass="25459" checksum="96C0741F9CA7436B" modified="2023-02-22" version="1">MRIIQFRPYSAAPRDNSNYSDVTMFLRWAFPRVELEAYNVDASKAVFFLILAVHAVLPIQAEIKPSLDPNQPQEKQAGGEDQHPYQITTFVIVVLMLVMMVIGMIGVIWFCAKTNRTGTDQHQLSPYVKFTSSDVENGDGEAETNNEEEQVPELDLPTSSQPGACIASISASVAHGTSTSNPPQNQDPYEKSATEIHTVIDGNNNTVHISSGVRYYMNSGYTTLHSDTDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI57</accession>
    <name>A0A914BI57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="10">PARP</shortName>
            <ecNumber evidence="10">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038075117.1">
        <property type="nucleotide sequence ID" value="XM_038219189.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219189.1">
        <property type="protein sequence ID" value="XP_038075117.1"/>
        <property type="gene ID" value="LOC119742923"/>
    </dbReference>
    <dbReference type="GeneID" id="119742923"/>
    <dbReference type="OMA" id="SYENIQM"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="866"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="937"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="1363"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="15">
        <location>
            <begin position="1664"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="14">
        <location>
            <begin position="1793"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="13">
        <location>
            <begin position="1937"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1455"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1637"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2154"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1463"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2155"/>
            <end position="2185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2185" mass="245376" checksum="60D2A59DF7C22A5F" modified="2023-02-22" version="1">MRVKVVPNNQLTPNLNIKVVQKDPMFEVKNESEIPEVSKFVQCKRSIRAVLTNDMSLLKKLIENKNVPSVFHKRSVSDERTALAYAVRTENHAALRLLLPEIDNYRERAKLPDVVMEYQSSGRARFANSGFGQGFFMGRGNKEGNNAFTKDLSQRVDLRQNYIDEVIKCGVSTGTIDLILATDTEDGEPEDTLFKSIHKIARAGHYKLAGYLVDKARQLSRLGFNKVHQEVLLAKQPEDISRCLTVSVKKKAYWEVDKITPVHFAAINPNPKILDKLMSILPEYSIMDSYGLRPIHYAAVCEGSGPLELLLNRGVNPEDKHTGGVTPLMMAAKAGRAKNVEVLLKSIEEKRKTIEEDRRKNIERLRKIAEEKGETFKEEIEPEDHSGVKQKTSGGNMAIHFASEGGSVDCIQILVNHGADIEAKMGAFYNNITPLMIATLHGHFQAVEALLDMGAVIEQKDKFNRTALMLACMEGNYPIATLLLRKGAIPDAQDSSGNTPTHYAAAYGWWHCLKLLLKAGADPNFTNDWKTTPLGVAFMKGHIGCSDLLLEQPTVNVNFRDNSGATLLSLTAESPLTKDMVDQIHYLLEKKADLTLVDIHGRNVFHYLATSSPPRDCDDETKKAVKSAKQGVAKLLIEKGCDASARDKDGNTAVNIALQQVGSGNMDPEFVKLLLEHGFSLSLNERVEDGKNALHMMAQKCAKVDMGALLPVIAKNMKQEKSRMKTGDGSHAPRTVTLEEAAKVVDNDGYTPFLRCVSQKYPSNNAQQSANVLSMVKALVEVAKSDINTVVGDADDSYKQYSALHFVCTHADEMSTLNMLLKWKPNLELFDNAGLTPLHLSVQRGRKDAAEILVNAGADVNKCTRGNSTSLLIAASLKMDDILPLLVTRGANVNAVDPDNKKTALHYVMTPFSVSHCLANCKVLLNAGADPNALDAKGRTPLHYAVNLDGGSFDGAPSISELLIKNGASVFVRDIRGRLPLHYAFVKMRKHRSRDKTDPIEIVTVLLDAMKGQQVDTQDKFGQTPLHWAAYRGATISAKYLVQKGKNLEIKDRNGNTPLAMTALGGHDSVAIVLIEAGANINITVTFVPPELEDLANKGSTEPSKSWIWKPLIQPQPVPFTASFVQAVLGEGWESVIFLIMPRMQKFRLSFISVMQAIFEAQKLQLACTMLLKQPDDKKVQATDSRNRNFLHLLAIHSNLDDPVQIYEEIANPLLERGVKLFARDDKGCTPLHYAAANQNNRLCKLFAEKDQASFKKCLSCKDNRGRTPTVAVFWNIGHSNLTEEVLNLFTSYNASLDIRAQLPDVQARIPQQRADTIDAWYHGPLEKSVSSTPLILMIHTNDFKGCKFLLQKGASCNYADENGLTPLMHAVQQNEMELVKLLLDHNCDKHFERGEGNLNAGSLSTWAVNLWEQRKSKPNDKERYIKTNTLGKLDGLDYIDQVSDYDISKALEEEDKKKNEEKDEMEDEEEVEEDEKNKKDLEDEDEKEALLEARKKEKRKQLEEEKRQDAAKKFAETSKVDLNAVDSAGRTAIHHLVKTHSYGTHENVIMLDLLFRLGAKISMRDKHEQTPLDYAMEMRSAKLAIELQRFMKIKESKWKLPKPTPLSWTDANHFKAHKPDFKADAQAMIKQLESSAARAKTKGKKKEEETGAKVDPLSNFKEGGVVLMDEEQGIPFDALLTRVDVKHGMRGMNNFYKMQIIHQTGKDIILLFTRWGRIGEEGQYQRTPFSTKEEASKEFRKIFRAKTRTDWADVKNFQKVDKKYQLVPSDPWRATRKEALKEFKFDLESKVPSKLPKVLQKAIKELIKPNVIAKALSDSGIDTAIMNMGNHLPRESLLKAKEVLVKIREVLEQVDEDKKASTRDMLKYQANMDKVWDLSSEYYQLIPCVNFTYDRIPPLTELRTLEQNAKKLEILLDLATTNLILLGAQYRVKETNPLDYISSCLGCQIQIMDENDQETQLILQYIDNTTDKDKHSVCAIFRLAREGEDKELRSLKLDNHRLLWHGSKCSNVISILKRGLLITPPEAAVTGYRYGRGIYTSDAFAKSIDYSIESFGRKNANFVFLCEVALGKMAVDHSDPDSVVKDGFDSLQAQNYTKILLPSRNIYLPSGVTIPLARLQDSSSYRRYFDYTEYVVHRESQVCLRYLVQCHPDESEDDDDIDGEDYYGYDDDGDDDDDDDDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK46</accession>
    <name>A0A914BK46_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075814.1">
        <property type="nucleotide sequence ID" value="XM_038219886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075815.1">
        <property type="nucleotide sequence ID" value="XM_038219887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075816.1">
        <property type="nucleotide sequence ID" value="XM_038219888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075817.1">
        <property type="nucleotide sequence ID" value="XM_038219889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075818.1">
        <property type="nucleotide sequence ID" value="XM_038219890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075819.1">
        <property type="nucleotide sequence ID" value="XM_038219891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038075820.1">
        <property type="nucleotide sequence ID" value="XM_038219892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BK46"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219886.1">
        <property type="protein sequence ID" value="XP_038075814.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219887.1">
        <property type="protein sequence ID" value="XP_038075815.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219888.1">
        <property type="protein sequence ID" value="XP_038075816.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219889.1">
        <property type="protein sequence ID" value="XP_038075817.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219890.1">
        <property type="protein sequence ID" value="XP_038075818.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219891.1">
        <property type="protein sequence ID" value="XP_038075819.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219892.1">
        <property type="protein sequence ID" value="XP_038075820.1"/>
        <property type="gene ID" value="LOC119743474"/>
    </dbReference>
    <dbReference type="GeneID" id="119743474"/>
    <dbReference type="OrthoDB" id="9882192at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23637" checksum="46C0CF20A763AD8C" modified="2023-02-22" version="1">MKGTIERLRTKVEYLSNTNMSLKQQLSMIHTSSLKHLTNDSENQSILQELLQHMSEEHTQLLHHHLAQLRLYTQACALSKSAPEESAAESTVLVPDLADQSQDISHMAMMSSSEGTLGNMEQTVVMTIMSEEDSEPLGNIVDNPGDTVGYDSLTLDKDVHLSPNDILYQLTSEGLSPRHATSESGHVYQSGRTHSHHNTGCDVSQQDFHKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKA7</accession>
    <name>A0A914BKA7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076350.1">
        <property type="nucleotide sequence ID" value="XM_038220422.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220422.1">
        <property type="protein sequence ID" value="XP_038076350.1"/>
        <property type="gene ID" value="LOC119744485"/>
    </dbReference>
    <dbReference type="GeneID" id="119744485"/>
    <dbReference type="OMA" id="EPEMQFH"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037272521" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="11">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="485"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="562"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="601"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="809"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1288"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1331"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1360" mass="144153" checksum="0AEE2C52FCF26CA0" modified="2023-02-22" version="1">MAVVSRTVFLGVFLCWIITGVWSRPNGAPTTACVSMLPNHGVPSQAANTSPFTVTADTTDFTTEQVITVTVSSGGSVTFKGVLLQARVVDTDTPVGVFSNIPDGYQPLNCSSADDAVTHANNNVKNSLTVEWTAPSNALGDIEFVATVVYTREIFWSQLRSSVITALPDVCLSEPCFNGGTCYRASDKRSYFCGCTAPSEMGPNCETLNPCNPSPCLNGGVCFRSATSAAHYTCLCTGHYSGQHCENVIAACSPNPCLNGGVCREAGDTFSCFCPSDRHGARCEFEIITCDPDPCLNGASCLATATGHECICAFGWSGDDCGTSLICQADSCLNGGTCFDSNPPGSVMFYCYCNVYYTGSRCETADPCRADPCANSGTCNQVGDTEAFTCSCIDGFEGERCETTTNPCQASPCMNGGTCFRDTNGATMCQCPSDYIGDVCQTRVHPCDLPVTPCMNEGTCFKGSSGYSYFCQCPSGYSGMDCETLDDPCASHPCMNGASCTPGSGEEYTCTCPAEFFGSNCQNRGACFGADCQNGGTCIPRSDQLAFTCQCAPSYDGPYCQYANGCELNDLCLGGSTCSYIGQGFTRCDCPDGLAGTYCELDVSCSGTPCRNGGTCRPLGDGSYQCDCLAIYSGSNCEIYTNPCMPDPCVNSECIILLDPDTAWNCTCGKDYSGENCTIYNGDPCDVFECFNDGQCISGAQGSTCVCGPDYSGEHCERPLNPTLTGCPSGLAISYPLQQGSNSAYIDLSITARGHLNQLIPITVTDELEFPSTIMFTEEYREGKDITVQAVDENNENRTSTCSFKLRILDNEIPTVQCPADMSTITAENSVAVFFPMATAMDNLGITKPLQYTPSNGSQFDAGRSHTVIVKALDTFDNQGECSFQVVVNKKESDCTEPTAPDNGVSTCVADGESRTCSVSCNEGFGNAVGINEYMCVHQSPAYWTPRPNTDICVPYKPGNSASKVVSLRFSIDSALCNTLNFDNSVADSLTESLQALGVCETNDARMSCSFELECGSGSGAGRRRRANVDLNVDLGLTSLAGEDDSTADVEARLDGAVDNVKAGVATSSLSIEIEGETIMNEPTALGESDTTWNCKPGQVTKSNGCLSCPPGTYHDAVRKTCSYCETNTHQNKPEQESCSSCPDGTETQQNGAFSEDHCVPIDKEPLAGPWTPTLIGIVGGAGGLIVLLLVILACVCIVKSSRRPSHESRGESKESPLSNFTHLNKAYEETDETEMQFHGDPSIDSDNTYQNIVDDDQSRTGSTDYLVRIPSLSQYSDYYATLNARSAPNLEPETPPPPPPVSAPAPPEPQLNGGPPSPPPAPPAPPAPGLNTNNSNMSTDHTHLNGSVANGGTRAKFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKN2</accession>
    <name>A0A914BKN2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076346.1">
        <property type="nucleotide sequence ID" value="XM_038220418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220418.1">
        <property type="protein sequence ID" value="XP_038076346.1"/>
        <property type="gene ID" value="LOC119744482"/>
    </dbReference>
    <dbReference type="GeneID" id="119744482"/>
    <dbReference type="OrthoDB" id="10180424at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037333107" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="22827" checksum="0E63F4873080F8E8" modified="2023-02-22" version="1">MARTLLLSLAVFLGFQVVAGIVSEWIAKDEMDKVCMKIKFDGMINVRDNPEYNTDFGSAVVIDPKPNCMEDERTITIGVGNSSLQLTFRKQSQSFVFTNITAKWLKPGSGLENVTGSLSDKNFLSGAVPLGCFYSQDEPLSIPFQGGFSAELKNVTFQPFADCAKNDYGNDYSSRDCPTDCSRAARPGSDIIYVLLVAVVGAISVKFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLL3</accession>
    <name>A0A914BLL3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076352.1">
        <property type="nucleotide sequence ID" value="XM_038220424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLL3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220424.1">
        <property type="protein sequence ID" value="XP_038076352.1"/>
        <property type="gene ID" value="LOC119744487"/>
    </dbReference>
    <dbReference type="GeneID" id="119744487"/>
    <dbReference type="OMA" id="YWIGQND"/>
    <dbReference type="OrthoDB" id="538816at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037272141" description="C-type lectin domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="238"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="403"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="555"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="689"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="691"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="769"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="902" mass="100040" checksum="8A938FF1CEDA231A" modified="2023-02-22" version="1">MAFVWRECFRWAPLVFLLIVTPGALAQDSDADQMPGFLEIGPATIAPASTISCEDIHGDSFGNQTAKPGVCYLVADVKGDFHDARAYCQALNDSLGWDVADIEDVVENMLIQDALTTLKENGSLSSATTFWVGQNDLETENTWAYLNDSSNACNRSVYLNWRYEQPNGGRRQNCIAYFYNENGNFQDRKCDDDYYYLCKVKVTSDTVPSCPDFVEDISTEASDACLDIWPVAFSNPAVPGVCYAHESYQQFYFEDALNFCKSLPGGSWSVVDIEDAEENLFLEAWNRDNFPKNNGYWIGQNDREQEADWRYTSSGQCPVYLNWRNDQPNGGREQNCMVMFKTDDGAFQDKACNERRYYSLCKLKKDPGPTPNPEFINCNGSTLPSEVAECTSLKSGAFGSVDNPGYCYYMSGNQMTWEQAVQSCQALGWELIDIENALENEILAARFRDFWPTKRYYWVGQNDRATEGVWQYSSNSTPVAFAGVYLNWEDGQPNDVDHTQNCIMMDKTGQWEDKSCTSYYYVTCKKRVGQIPTTTAAWTDPCPKYQESAFGDEANPGVCYILTNEKNTWEEAQKVCDGFGSGWQVPDIEDDADLLALVTMNSRSFRSNDGYWIGLNDAATEGTWVYLDTSIPGPAYERWDSSGNNQPDGGVSENCAVFQESRDGKFKDVPCGSESFFVACKNRNAYDVSSTVTTHEPTTDATTTQSQTTEGATTQSQTTMGATTQSQTTEGLTTPPSIGTTQLPTTVATTRQQTTESATTGQPIDTTEQPTTKVTTRQQTTEGATTEQPSDTTEQPTTEATTPQQTTEGATTEQPTDSSPITGSGRFVFKSADATCSSATALHTSSARDRFHCARKCLIQGNCRSFSFAASGEEDACELCSEVLDADNLQRKIGSVYYFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSB6</accession>
    <name>A0A914BSB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079183.1">
        <property type="nucleotide sequence ID" value="XM_038223255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223255.1">
        <property type="protein sequence ID" value="XP_038079183.1"/>
        <property type="gene ID" value="LOC119746360"/>
    </dbReference>
    <dbReference type="GeneID" id="119746360"/>
    <dbReference type="CTD" id="9318"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000001">
        <property type="entry name" value="Putative cop9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="247"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="51857" checksum="7C5D6E3015005C02" modified="2023-02-22" version="1">MSDADDDFMCDEEEDYDLEYSEDSNSEPDVDLENQYYNSKALKEDDPRTALDSFQRVLDLEEDKGDWGFKALKQMIKINFKLGNYEEMMKRYKQLLTYIKSAVTRNYSEKSINSILDYISTSKNMGLLQEFYETTLMALKDAKNDRLWFKTNTKLGKLYFDREEFNKLAKILKQLHQACKTKDGSDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLQIKSAIPHPLIMGVIRECGGKMHLRECEYEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSDINPFESQEAKPYKNDPEILAMTNLVSAYQNNDINEFEKILKNNRRNIMDDPFIREHIEDLLRNIRTQVLIKLIKPYTRIHIPFISRELNIDVSEVESLLVQCILDNTICGRIDQVNQLLELDRHSQDTARYQALDRWTVQLASLQKAVGNKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSV4</accession>
    <name>A0A914BSV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">THD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078686.1">
        <property type="nucleotide sequence ID" value="XM_038222758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222758.1">
        <property type="protein sequence ID" value="XP_038078686.1"/>
        <property type="gene ID" value="LOC119746008"/>
    </dbReference>
    <dbReference type="GeneID" id="119746008"/>
    <dbReference type="OMA" id="ICINDRP"/>
    <dbReference type="OrthoDB" id="6159739at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051748">
        <property type="entry name" value="TNF_Ligand_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151:SF24">
        <property type="entry name" value="A PROLIFERATION-INDUCING LIGAND-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151">
        <property type="entry name" value="PROTEIN EIGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="9">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="396" mass="43040" checksum="1D8836C569DD394C" modified="2023-02-22" version="1">MTKSHPYQRLVDPEVCRAKSAAGLSRTVNAVLVVGVVAVLLTVVVIGSLLAYVYLLSAEPCSSSSAGIQPCSSPGLASSSSVDVDKLLERLDSLEREVAALKSECRRWSSSDSGHDNQQSSDQGSSAPEPTTFLQEDVQGKMSPEESPSSTIIPTWPTIPTRPPLDDDLALTLALNSDLELSPRQQHRNPSSKNRMKRRREESPDDIAQPLEEEERGDGGRGDGKKKRDKRCKHCIDNDKPVMKGIGTDDALQARVLMFGKAAHVHGNRDGNIPIPGDGWIRGPQMWEMSPSAGEFVSLSIVGSVTVHESGWYYVYSQVLFYDSNNTVGQSICINGQPRFTCVKSNISADAKQSTCYIGGVVHMSEDDQIAIKLSIPNVTVALYADTTYFGLFRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1M3</accession>
    <name>A0A913Z1M3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045723.1">
        <property type="nucleotide sequence ID" value="XM_038189795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1M3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189795.1">
        <property type="protein sequence ID" value="XP_038045723.1"/>
        <property type="gene ID" value="LOC119720207"/>
    </dbReference>
    <dbReference type="GeneID" id="119720207"/>
    <dbReference type="OMA" id="CKDEEND"/>
    <dbReference type="OrthoDB" id="548295at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="980" mass="108132" checksum="4165E7202A78B5FE" modified="2023-02-22" version="1">MSKNSDQAMSSSSNNSFFNLMGFIKKKPPLPEGWIVKQSSTYPDRIYFFNVRTGATTWTAPGAMSSDTGSTISDTSDKPLRSKTRAAHPATSQTPSGVPASSNTRRLPTPTHPGNKPQPSRVTSPPAKGRSESLGKHASKIKSPSPVALKREDWLKVQHFKLTNMSRIQKATKRRLQEEKVRMVTPSPPWGIPLKGSHPAGTLTPESLTPKSLTSPNGRDASSVSSRSSKLGSPAKSKPLRGSPTNSKPQQVRKKRSFESDSSDSHALDSRAKSKHLKATIGQKPLSDSRSEATPRLPTTRNSSNNSGKTVVKQPQGTTPADKRDLRIHMERSKQLKTVPQQPQREKQASRNQAAKLPSAPTSAPKLPPTANHTGKPGSESSASVASRDSQPSSKPKKTSRASWRRKEFKASAKEINCKGSNISFVKNYVSTVAANTNSAGNSSSCGVFNKGPGVSSFPAAEEDDELCQMEIDFPDDTVDTGGNSDNKNVHLGLRVVLDTNVLMHDLKFVKDLLDKRIQGLGLPTLVIPWVVMQELDSLKIGSTKGGAAWNAVQFLHKCVMNEHPRVKGEPMRKSSEEADFEITCNDDWILQCCLQQQKIVGKDLVVLLTNDKHLCSKAVISSIKAFSKETLLSGLEALSDILQHRPPLPPVPTDSPAPETHRPRTPIESPLTANAEKELCDELICQVKETLLQGLTVVLEKEMKDAYEDLWTEIVIIKPPWSFNDVMQCYEKHWIAVFGFFLNREDRRHFQQIVELTSILNVSLDSVKRLINSSVYFCRRLHNQKRYGTALEQPILRLGDFKKRCLAPSPEGKQSPNQALPSEDLALKLSGATEIVPIVFEAVWLKICQLSALIFEGLGIPHDLETDKTSVIPSALECHACLDILCPLLQQIIKALERVTEIPDSCIGETPLPFERLCQTMQIFLREFISHDRERYASLTTLALQKFVMVYSNRQLLRNGIVQLANALTRLAQCHGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2G6</accession>
    <name>A0A913Z2G6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046023.1">
        <property type="nucleotide sequence ID" value="XM_038190095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190095.1">
        <property type="protein sequence ID" value="XP_038046023.1"/>
        <property type="gene ID" value="LOC119720431"/>
    </dbReference>
    <dbReference type="GeneID" id="119720431"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="27134" checksum="88A3138157B77C0B" modified="2023-02-22" version="1">MLGGQVHPHEDEVSGKAKEEEEYEEKELEKDVTATENEYADKSEKRHKAKEEDREEENYKEKEEEKMVKAEADEERCASAQSQTRNMSPTSTQTGEESRTDSPTADSDRQGNFEYSDQSGESHSSTVEDQTNTRQESEGVTTTKSDDRDERAESLGPDDEKKENYGKGPQKKLRNTRRMKRKRKERVPVTYQAFFKHGRGTFAWVFRAKAREKDQEQYDKEEEKEKAKEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2K7</accession>
    <name>A0A913Z2K7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046063.1">
        <property type="nucleotide sequence ID" value="XM_038190135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2K7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190135.1">
        <property type="protein sequence ID" value="XP_038046063.1"/>
        <property type="gene ID" value="LOC119720463"/>
    </dbReference>
    <dbReference type="GeneID" id="119720463"/>
    <dbReference type="OMA" id="WCANDDS"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977361" evidence="2">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="35048" checksum="E7B6660ECBA4928A" modified="2023-02-22" version="1">MRRRRSSEALFVAFLLFVVTIQASVGTTTPPVDGSPTPPDATLPQAIPPGTATTAGTTTPQVDGSPTPPYTTLAQAIPPGTSTAAGSTTPPVDGSHTPPYTTLAQAIPPGTSTTAGSTTPPVDGSSTPPYTTLAQAIPPGTSTAAGSTTPPVDGSPTPPDTTLAQATPPITSTTAEMGTSQKPTPTPEPATTPVQTTTSEPTTTGGPTTTSGQTTNPEPTTNSGPTTTPEPTTTPEPTTTSEPTTTPEPTTTPEQTTTPEPTTSPKPTTTPEQTTTPEPTTTPEPTTTSGPITTSEPTTTPEQTTTPEPTSTPEQTTTPEQSTTTPEQTTTPEPTTTPEPTTTSEPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2S7</accession>
    <name>A0A913Z2S7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046012.1">
        <property type="nucleotide sequence ID" value="XM_038190084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2S7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190084.1">
        <property type="protein sequence ID" value="XP_038046012.1"/>
        <property type="gene ID" value="LOC119720419"/>
    </dbReference>
    <dbReference type="GeneID" id="119720419"/>
    <dbReference type="OMA" id="DQGEAPC"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="99" mass="10781" checksum="4AF6A3C843D1B80C" modified="2023-02-22" version="1">MAGAPSSTVTQTPNIDYGQYKETAVEKLKRKAYDEPFVPLGITAFVGALVWGAVSYKHRKGMSTSIYLMRLRVVAQTCVVGAMTVGAAVTMFKNTMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4D7</accession>
    <name>A0A913Z4D7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045856.1">
        <property type="nucleotide sequence ID" value="XM_038189928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4D7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189928.1">
        <property type="protein sequence ID" value="XP_038045856.1"/>
        <property type="gene ID" value="LOC119720287"/>
    </dbReference>
    <dbReference type="GeneID" id="119720287"/>
    <dbReference type="OMA" id="PQGINED"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="458" mass="50344" checksum="C8F2FFC2DDF713A5" modified="2023-02-22" version="1">MSCAICMEQLQQSQQPKVLSCGHSFCLACIEHWFDSKQRRAPKDGSRRRAVRCPVCLQYTPLPTEGLTSLPTNFALLEAREENSIKLCDDDDGDRSSRMCLLHVGKILEFQCKTCAGQLVCRQCVGSQHRPAAGHRIGSLASLVRRQSTERAELEQMVMELQMRTIELTESNAVLQLDLLDRESNSKTNFITTTEKDINSEKSGTGETSKSETGCSSDDTVILGTETYQTQPRPRLRSGNLPEGKRRPPPVPPNLKTKSLPYAGLERKYGVPPPPPSSHTRDNRQSNTLPIRSPPPPPPSSANQRSAGQGLPTSSHVADGYQPRRYPSRNNRQPHTLPPPPPTAPSENHRSAGPESPTSSTAVGDQQTVCDRLAPSVLPRRHQPAGVTRVDSRSLRPHLHARVPSSTSAQSDNSMTESPSHLETNQQSYPRRSRGMAPPPPPPRPKTRPPSHPAGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4J9</accession>
    <name>A0A913Z4J9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045660.1">
        <property type="nucleotide sequence ID" value="XM_038189732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4J9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189732.1">
        <property type="protein sequence ID" value="XP_038045660.1"/>
        <property type="gene ID" value="LOC119720168"/>
    </dbReference>
    <dbReference type="GeneID" id="119720168"/>
    <dbReference type="OMA" id="MHIESIY"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="995" mass="111509" checksum="CAA688B7ED43C0E3" modified="2023-02-22" version="1">MQQEAQVPAPSVATGSPQPTGTIGNSGTISGSNNPNIVGSSGVNINYNFPLEGPGLPASRPQLSQRPDQEPRLGASSYQDVGNKTRDILKEVYTTTGSYVRLLPRCRVGNDQMHIESIYTKVRLETREGVAVVCTPTGKTATKSSQRGETVNSIEYDKIFRFRKGTKELIKRLIFVGEGGVGKSTIFDKIVNDWAEGEDEFLKRFDLVFLLKMCALRQESDLVESMLNQLLDEDSGIEKDALEKVIQAKPNEVLILLDGFDEMMTKTLDEASFGSILKALNRKKYRHCCICVSTCPSRLETLMSTSLVQNPCTHVEVLGFKEEDVNEYIQKFFKEDSDSSNALIKSIEMSKTQQDFAKIPMLLLLMCLLWREHKQLPETTSRLFNKAADHMFSTKDNDKERPPDAKKRKPNISNVSKTVPIEIGQIALRGLMTDQFSFQEGEFEPEALHLALKAGILTKQSVVKNLKSHNSIQFMHTMQKYCAAKYLQSLEKGEFQRSLEPLCTTIDRVVSNDDLLRFCCGDNERCMTGIVNLLDHKFNQPQPRYQSDVVQVISRNCFFESQSSKVPRCLTSDSHIPSTIDVRNNNDLRSLVYLLEIICKSDSSKAQLTCVKDINVSRASSVSDLAFALRYMENLSSLELDICPLGNSAFVKILSELKCNQQLTYLKLCRCDGLGGRAVEWAPHIKHFTSLKELQIWECKLQAADIEHITSSVSDMPSLTHLALPFNDTLSETASSWSTELPKMTHINELGLSYCNFTPTDIEHIASAVGDMPTLTDLELDEAKTLSELAESWAKELPKMTHLKKLNLENSNLLPTDMKYIATAVGDMPSLTFLNLSFDDTLGSWAHLWAKELPKMKHLNKLHLRCCCLSPTDMTHIATAVGDMPSLTDLNISENTFGGLLWANELPKMKHLNKLHLRSCSLSRTDMKHIIISAVGDMPRLTDLDLRGNPRLDGLDEFGLQSRSPSLTVRMGSWYGTNCNELSHFKEVTRVESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6P5</accession>
    <name>A0A913Z6P5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047374.1">
        <property type="nucleotide sequence ID" value="XM_038191446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6P5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191446.1">
        <property type="protein sequence ID" value="XP_038047374.1"/>
        <property type="gene ID" value="LOC119721385"/>
    </dbReference>
    <dbReference type="GeneID" id="119721385"/>
    <dbReference type="CTD" id="9444"/>
    <dbReference type="OMA" id="KIRRQDM"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000028">
        <property type="entry name" value="protein quaking isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="147"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="462" mass="50829" checksum="8E87F987302BF531" modified="2023-02-22" version="1">MSVVVPNDRGDGLSVVPPGTNSMSLPVPISIPPPNSLVNSVVPSNAALTGGVFLPGPMPVPLPVHTPPMKIMADHHTTEKQHPPIPNNTDYLAQLLNDKKSLVLVPNMFIHVERIIDEEISKVRKNMYNINNDNTPLVLPEPQGPTITLSEKLFVPVKTYPDFNFVGRILGPRGMYAKQLEKETGCKIMIRGKGSMRDKKKVWKEEMNKDKHNWEHLAEELHVLVTVEDTANRAGLKMERAVSQIKKLLVPTADGEDELKKRQLMELAIINGTFRDTTSKAHQSSNPNTPLSKCAESDNTQQYLKYEPYGMRHLTTVELPPGGCTFIPASPRQMIPPGTALIPQPLRSPTPAANPQLIAHPSAALFPRMASGQTILANGMAPPMVSTADGTSIMFSPYEHYPYAMTPTMLDYPPTPSEGTIGAVPKLRRAIREHPYQRVLDSRDLSSMVMGATLPLPNPLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7I0</accession>
    <name>A0A913Z7I0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047644.1">
        <property type="nucleotide sequence ID" value="XM_038191716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7I0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191716.1">
        <property type="protein sequence ID" value="XP_038047644.1"/>
        <property type="gene ID" value="LOC119721750"/>
    </dbReference>
    <dbReference type="GeneID" id="119721750"/>
    <dbReference type="OrthoDB" id="6117453at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025452">
        <property type="entry name" value="DUF4218"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48258:SF8">
        <property type="entry name" value="DUF4216 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48258">
        <property type="entry name" value="DUF4218 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13960">
        <property type="entry name" value="DUF4218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4218" evidence="1">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="358" mass="40392" checksum="39590C75FA69B5A0" modified="2023-02-22" version="1">MTAVKFDFDDLDTNRFCSVMMTKKKCGDVLMPWLDDKPLEELNIVSPSTPASLTVNVSLAVNASLGHHHHQMCARGMEVVGSCHDFVLFGLFTGRDDTVKMRAAEMRAAEMAMDRHQHNRQNSPWTLTSQEKKTADDRLLQVRVLCTRLPSQFSTSALPYMKCSDWKKLASNSILKYAFRDMFGDNQQQTFFQLCDVLAELMDHSVDLTCLAILEEDMHHVPSLIERDFPLGIQTLCMYIMHHACATLKEFGPASSQWMYGFERFMAFLRGGILNRRLPEANAIEAYRIYEFSQFIAMAGLLPEGSICTSNTLTVLAATEDQNKDDMGNACILVIHRFPTSICIVKCSKSSQNLKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z937</accession>
    <name>A0A913Z937_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 77</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048159.1">
        <property type="nucleotide sequence ID" value="XM_038192231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z937"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192231.1">
        <property type="protein sequence ID" value="XP_038048159.1"/>
        <property type="gene ID" value="LOC119722185"/>
    </dbReference>
    <dbReference type="GeneID" id="119722185"/>
    <dbReference type="OrthoDB" id="191169at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="41546" checksum="E9CEC052665E4F25" modified="2023-02-22" version="1">MDTLSFGTLIHSIESPKFWTKIYCAVWALRFSAPCMLRLMVHDRTHKLEWELRQREEEIAELQKALSDMQVYLFQERDHVLRLFAENDRLKIQELEDRKRIQHLLSLSSPSGPEVTYFHKEPSTRAIVTQKHPQKRHPHAEGEILGFKSQSAKQTTEQEMQTVIERDRSKIHSLNEKLHRTQQMLYDSTKDYLELKYEGRSQERVWMAEKDRLLQELDRCKEQLDVSKDDVLVISDHALEERQTQNLEIEDKTEKLAKRLHLMNQRYEAMEKRRNLEIEGFKNDTRILRNQLKDVEKQLYKVTVGVGEDGDMFMLHNIHQTAKRSKKMQSELHQLKALIYGVETDLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA83</accession>
    <name>A0A913ZA83_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047911.1">
        <property type="nucleotide sequence ID" value="XM_038191983.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047914.1">
        <property type="nucleotide sequence ID" value="XM_038191986.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047916.1">
        <property type="nucleotide sequence ID" value="XM_038191988.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047923.1">
        <property type="nucleotide sequence ID" value="XM_038191995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191983.1">
        <property type="protein sequence ID" value="XP_038047911.1"/>
        <property type="gene ID" value="LOC119722009"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191986.1">
        <property type="protein sequence ID" value="XP_038047914.1"/>
        <property type="gene ID" value="LOC119722010"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191988.1">
        <property type="protein sequence ID" value="XP_038047916.1"/>
        <property type="gene ID" value="LOC119722012"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191995.1">
        <property type="protein sequence ID" value="XP_038047923.1"/>
        <property type="gene ID" value="LOC119722020"/>
    </dbReference>
    <dbReference type="GeneID" id="119722009"/>
    <dbReference type="GeneID" id="119722010"/>
    <dbReference type="GeneID" id="119722012"/>
    <dbReference type="GeneID" id="119722020"/>
    <dbReference type="OrthoDB" id="10066781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="682" mass="76617" checksum="D822249890CEDC5F" modified="2023-02-22" version="1">MLSTDVPCRPDPSAFDILEDICGGYVYGNQKTECHIDMESFHSIIDDRHLLQEPVKLPFQNKVIQAHGKTVQMTTDNSESATEEDSSDTSENSSDYHGSESDESESDEESIVFDQLTDNSSQFQPRPCRGKAELEANGKVQPSSDSSSDGSDSSFDEIHIEYYKQKEVEGGLIRAYNKFNACLFCEKLVNDGGVTMGDFLKPSKFDAVIQAVEDLAGQDEGEGGDHELQRPSFALKAGYDLAWLARIKRGRAIRSHDITSEEEANKFLQLHRSEWGLKVSASACNTLNTRKSKKPVSLPKTSDLQKLSKYVTSEVKKCNEMFTTSSTANYSFLKRMQKVTLVRLLLFNKRRPLELSQITTDTYINRPGWNNSRVEELLCQMTSLEKKLLESHDLLKMIGKRGRTVPVIVPPDCSKSLNAISKLRHLFIPPSNQYMFARNTPSTHMQAGHVLKEIISEVSLDSPQDIRTTKMQKYTATVAQILSLQPHQLEWVASHLGHSVNIHKDFYRVQDSTIELCKVSKLLMAIDAGDVGQWAGKSLDDIQVEDIEMEATDEIDDDGDEDEQEMNQVSLQTCFNKSSSAREPSPSCAPRCTPRRVETETRSSSREMPSELAEGSRPLRVSGKGDKFPWSKQETSCIWAQMRELILKEKVPGKKECQACITASVPILDKRTWQCVSIRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD42</accession>
    <name>A0A913ZD42_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049702.1">
        <property type="nucleotide sequence ID" value="XM_038193774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193774.1">
        <property type="protein sequence ID" value="XP_038049702.1"/>
        <property type="gene ID" value="LOC119723212"/>
    </dbReference>
    <dbReference type="GeneID" id="119723212"/>
    <dbReference type="OMA" id="GEWATIC"/>
    <dbReference type="OrthoDB" id="10159327at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="810" mass="92199" checksum="0A2D6DF7292B8CDB" modified="2023-02-22" version="1">MENTPSISKVYQRMTAWICRRIPSALSGVSHTKVQVLSSTHCVPPEADFKCPTPEKSCKTWASRIRPNPKPENYPGNEKGGDGKPVDEITRNFSHQARDKHISTDEEHPPTCCPFLPGLRLCRLSRRRRAKVAPFDPPSPPIKANLESAIGGEDTRVHPLTTEVSVFDLEDVEGQESPGLGLPTRQMMEEDFNKWRESKRGEIKLGCEKDEIEGISRESILLPPRPKTSRGLGEKCGQRDQPLLGKGEQSDEKLNVWTINHNEVKQDDVLSLETENTVGNGTDKVLYYWKNLNVEDYEDGEIISTRSGGALATSSDEAVVPGQGEIVTDNDSQYEDSGGSLKSSEEDLYSSRPKTSRGHRRENGRGDSSSGRGGNRSATEVTTTATKVEDKVEDRQTISDNCIPQKTQFMESGMRSKESLSLEEPQGSGEVLNIWRNLDDIDLKDEERRQADESSEDHRYDRREKEQMDSRPNEVVPSSEKNSEVKNPKSSNESVDAAGVTMTSEEECQYERQQRQQWQLAAIGEWATICQDYDEDDYLVECYLRMDEFQKEQAIMKEWKSIVERYHSLGVIQDLQNIQTLCKCTINQSERALRQFARICRGPVPLSKSGQTKTEAIASLSRLVQQQTRMISEDVSNIFSESYQIFEELDLLRERQDRVEEFLENDLRRRDAEAALSRSSSRGSTITPRQVSSRLQQREIDQDLADTYMEKCRVRSTDLFNVMPTIYEDKAFHLEEIQEEEESDFPGYEEMNDNFPDYKVDVLENETANDREEVFLMKSAGSEDEKDGDVEQNQQDEQDVGEDEEPRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDZ2</accession>
    <name>A0A913ZDZ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049276.1">
        <property type="nucleotide sequence ID" value="XM_038193348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDZ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193348.1">
        <property type="protein sequence ID" value="XP_038049276.1"/>
        <property type="gene ID" value="LOC119722936"/>
    </dbReference>
    <dbReference type="GeneID" id="119722936"/>
    <dbReference type="OMA" id="CGTELMS"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="30814" checksum="602683A6E64B6967" modified="2023-02-22" version="1">MSFLCGPMRLRTKKRRGDSESLLHDDNVLTAAKIPNDPASQMTVLYDFISCLKDELSVNKGQTVDILDVDRKWAYVASGSGRGFVPLSCLGPSSAPKRSDSSTIGKPHTEHEDSPSRTGTESVFVRDPNGQYVVLYDFTAQDENDLSVVSGDCVMLLNEDDPDWTWVQKSDGAEGFVPRAYLYSDSIPTDNVSVSLSVQDSLPSSEAHLHKLQLCGTELMSLYDYQGRIADDLTVVRGDLLYADMTNQTHDEWIWAYCPRTQTCGFIPKGYARPPAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEI4</accession>
    <name>A0A913ZEI4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038050202.1">
        <property type="nucleotide sequence ID" value="XM_038194274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEI4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194274.1">
        <property type="protein sequence ID" value="XP_038050202.1"/>
        <property type="gene ID" value="LOC119723559"/>
    </dbReference>
    <dbReference type="GeneID" id="119723559"/>
    <dbReference type="OMA" id="RDPDYQN"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000027">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="75"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="350"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="561"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="834" mass="93772" checksum="C48EA43960709B9C" modified="2023-02-22" version="1">MSASRGEHNNSAGGPSLDFTLPMPQDEYGTYPEVSCDTVRQKLTPLDEILKTIPLEEFLIKDKANAKEQEKNLLWFHGKITRETAVHILQDNGNTEGLFLVRESTSSPGDFVVSLIHDSQPQHFQIHCLGDFYYQVDNGPLFQGLDALINFYVEGANGLSTRLVDFCKGEVPPAMARRRGRTTPLHRAVIDGDLKLINRILQSPYCCPLDARNMAGQTVLHDAAMLGDAKVVEKLLESGASVNCKDSNCVTPLHTACIHNLPHICKLLLQRGADPTLRHPMTGWVPLHEAAMRGHSKCVEELLRFGAPCHPRSVDNDTPLDLARRYEHDATIRALKNYQPLVPKTMKGHWDHGMLDRNKAMEVIQKQGAKDGQFLIRSSSHKVGIYVLSMAANGSIYNFEINKKGDSFFIDDGPYFDTIEHLVDHYMHYDDGLPMRLLQPISQYGAPANQYPAVPDHPPRGAVRNGERPPILGPRPPDLARELPVPASGPPSSPSKNMRKGPFADQQGSPPSARPSGFSRLFSKTKKRATQKLLQQQQQQQQAKAAANRETDMVNINAKDIVKGQEIGQGEYGSVLQGKWRNYDVALKTLHQEHLQAGQREFIREARVMHGLDHPCIVKLHGVVRGPPMMMVQELVPMGSLLNLLEDHPDQVLEENCRLWAAQIACGMKYLETKKFVHRDLAARNILLESKEQVKISDFGLSRATGENNDYYRATSGGRWPVKWYAPESIYFGTFSHASDVWSFGVTLWEMYTFGDQPYGDMMGSDVIKMIEAGGRLPQPDDCSRKIYDIMLRCWSYDAKDRPTFMQLNQSFSEDPDYREFYHAGVKQAPSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFL4</accession>
    <name>A0A913ZFL4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050239.1">
        <property type="nucleotide sequence ID" value="XM_038194311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFL4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194311.1">
        <property type="protein sequence ID" value="XP_038050239.1"/>
        <property type="gene ID" value="LOC119723585"/>
    </dbReference>
    <dbReference type="GeneID" id="119723585"/>
    <dbReference type="OMA" id="RVAHKCF"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="58"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="48709" checksum="F969E73AEAFB18CF" modified="2023-02-22" version="1">MYKLTLLVTSSRPDSIMAVIQIISILTVIALLYMSVFATSTGPDPQLELADANNRFAFHLYQTLADDPHRDNIFFSPMSISIALAMTSLGARGNTARQIKDVLKFSTLEESRLHSSFAELNSAIFGANADKYVLRKANRLFGHKGFDLRQEFLADAERYYSSHMASLDFVEDTEVAREFINSWVGRETEDKIRDLLPHGSITGMTQLVLVNAIYFKADWVRQFDKSKTFDQDFHVSKDQVLEVPMMHRKSKFNFAEDITLRCKLIELPYVGQDFSMIVVLPDEIDGIDRLQKHLTNEKLQHLLNNLSNVTVGVAIPKFKLEETLHMNDVLYSMGMRDLFVRDKADLSGITGTRDLFVSSVIHRAFLEVNEEGSEAAAATAVTINKRSISLAPEFIADHPFLFFIADSKTKAIVFMGHCRKPEGVSLNHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH53</accession>
    <name>A0A913ZH53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">[histone H3]-trimethyl-L-lysine(27) demethylase</fullName>
            <ecNumber evidence="12">1.14.11.68</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60224"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15544"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.68" evidence="12"/>
    <dbReference type="RefSeq" id="XP_038051115.1">
        <property type="nucleotide sequence ID" value="XM_038195187.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051117.1">
        <property type="nucleotide sequence ID" value="XM_038195189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051118.1">
        <property type="nucleotide sequence ID" value="XM_038195190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195187.1">
        <property type="protein sequence ID" value="XP_038051115.1"/>
        <property type="gene ID" value="LOC119724231"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195189.1">
        <property type="protein sequence ID" value="XP_038051117.1"/>
        <property type="gene ID" value="LOC119724231"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195190.1">
        <property type="protein sequence ID" value="XP_038051118.1"/>
        <property type="gene ID" value="LOC119724231"/>
    </dbReference>
    <dbReference type="GeneID" id="119724231"/>
    <dbReference type="OMA" id="SHADDTW"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.20:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="1142"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="300"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="701"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1448" mass="157725" checksum="AA79AF9D1CD2B6DF" modified="2023-02-22" version="1">MFKVNSDYESSLKHYQLALIDSSPCSLTKAEIKFHIAHLHEIQGKFQTSVEAYEEILSFIPLPDTVKANSLRQLGWLQHSCEQLGDSASRETKAIQFLIKSLEVDPNSGQSWYFLGRCYSSGGKVHDAFTSYRHSIDKSEANADTWCSIGVLYQQQNQPMDALQAYICAVQLDKTHVAAWTDLGILYEACSQPKDALTCYMNASKCSKNSGTTSLGPRIKLLQAQVNASPQLHMQTKSKTLPSIEEAWSLPIPAELTSRQSNMTTIQQARMIPPSVAVTKAMPPPPYPNQLTSQLTVPNAAAPNCLPSQPTPVSLGGGVQSNTTSSGSTTPQPGNAPKRRKNSAAQKKKSSTSVAELLSIHQQQQQQQQLLQQQQQQQQQVLQQQQQQQPGSKQPVGPREQQPQPPSPPSFYLTPQQVALLQQLQQNQSSLNAEQTVVMQHLQHNLWLMQQHHQQMLKKHQQMQQQQEQQQQQQNAGAQLQLPNSDASGGIQQPPMQSLGGLHNVSQLGDSRPGQAHPADSLPASSGSDLLSRTTGRNVVSAVGSGVVVTANGGGQAVCTGGAFVSAGNTVTSVGFTSLGLGVSSAQAPGLSFARHPSPADTPKTQELFNNQTVPGSLQSRSITASPLHGPKRMVTPPGPAGSPQTTSLQKTLDSPAPNVVAPHDMNQKLAEFKSRTGSTAEPQSLMSPQEIADSMLAQLSHTDNTSSRSSGNFMGGSSPSENPTGVRHSSVGNAFFSTMPPGMGAGVSHESNSSRHEGGVFKTPPPVTSSVNSLESIFSQTFHPGADAKPKTPEHRAAGLGSPLHPAGPTHSMDGINSVVTGLNNAISNSASPAQSVGTPPSVSSQLSQMECGTGEHGMNALSGRGSPMGSSLVRRDGVTAGCVQNHVNGMGTGRYDQTLSVNTSSVSSRGSQAASPCLSPSGLSIYSSSAKVLEACRKLGKNGLRINSILLEKMPPPAPPPAPYPPLPKDQLNPPTPNIYVETKADAYSPTLAEYCTSPKQPITVIRGLAAALKLDLGLFSTKTLVETHGDHPVEVRTQRQQPPDENWDQAGLKKVWKCESSRSFTTITKYAQYQASSFTESLREENEKKFMADDPFSAKRKKKSNGGVAPGVREGGREGGREFKMLKFGTNVDLSDEKKWKKQLHELTKLPSFTRIVSPGNMLSHVGHSILGMNTVQLYMKVPGSRTPGHQENNNMCSVNVNIGPGDCEWFAVCNSYWGTIMNLTERYNINFLKGSWWPVLEDLYEENVPVYRFIQRPGDLVWVNSGAVHWVQAVGWCNNIAWNVGPLISSQYKLSVERYEWNKLQGYKSIVPMIHLSWNMARHIKIIEAKLFEMIKYCLLRTLKQTQLTLDSLKDIGVEVHWHGRAKNETAHYCVNCDVEVFNILFTTEKDRKYEVHCQDCARKASHNLEGFVVLEQYKLKDLMDVYDAFVLHVPEKDENRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHP2</accession>
    <name>A0A913ZHP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051303.1">
        <property type="nucleotide sequence ID" value="XM_038195375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195375.1">
        <property type="protein sequence ID" value="XP_038051303.1"/>
        <property type="gene ID" value="LOC119724356"/>
    </dbReference>
    <dbReference type="GeneID" id="119724356"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="594"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="315"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="901"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145490" checksum="97CBE27AC49B237B" modified="2023-02-22" version="1">MDGQIEEPMETNAESQENKENEPSPSQTDPPRSISHETSINTSQSSVNSAAKRPSPDEPRLMISKIVTENFKSYAGKISLGPFHKSFSCIIGPNGSGKSNVIDSMLFVFGYRAAKIRSKKLSVLIHKSEQHRNLTSCTVAVHFQKIIDTGPGDNDYNVVPNSTFVVSRTAYQDSSSNYYVDGKKVSFKEVTALLKLSGVDLDHNRFLILQGEVEQIAMMKSKAQTEHEEGMLEYLEDIIGSNQYKEPIEEMAKAVEQLNEERGEKLGRVKAVESEMEQLEKPMKEAQEFLKTENEITKKKHKLFSKYVQDCNVNEKKSEEKRNKVAEAFKEMKEELDKFAEDNKTKTKENKKIFKTYEKLSEIAEQKKADFAEFEQQDVKCREDLKHTKEKQKKLVKSLQKEKTKLEELQAVPAKSEQEIKELEAGKETLEKRLKTEEAKMGEIMASLKTETQDLQAEKDVKEEQLMGMQKAVNEAKSKKAEADFELETQVKKQGSAKAKLEKAKADLENTTTTLAERKGSIKELERQIPQLQSQLPKAQSDLATIKQAEAKASQELHALVTKVEEARSSLQSARDRGAVLEGLMEQARRGKITGIHGRLGDLGAIDEKYDVAISTACGALDNIVVNNIETAEKCVKFLRDNNVGVATFIAMDKMEERARNAQVKFNAPENVPRLYDLVRMKDPKFAGAFYYALGNTLVAKDLDQATRIGLQGSKRHRVVTLNGQLIEATGTMSGGGKQVAKGRMGCAVVVDITPEQFAAMERELEAKRTATAECRDRLRELEQGAHELEKQLNETKLTLKKHNMDIKAKAEQEVTLRDQIKELETVYKNSGKDVDMTALEKNAAKYTKEYNKVADAAAKVEGEVKVLHDRIMEIGSTKMKSQQAKLDKVTKEIDETSTGITKAKVAIKNAKRNIKRAEESVENMEKEEKENAETMQKIEVEFKRLEDDATRVLEAFREAEMQMKDMEGQLEKSKVELEKLQQQESEIKKRQVEVKHELEKYDSLVKENQQKGKHWKKELGKLELHALVGETSESLEELSEEQLAGIDTEEVQYEITVCEEQLAKMSPNLAAIQQYKKKEEAYLARVAEYDALTESRNAQRRSLEDMRKQRLDMFMRGFGSINEYLKEMYQMITLGGDAELELVDSLDPFSEGIVFSVRPPKKSWKNICNLSGGEKTLSSLSLVFALHQFKPNPLYVMDEIDAALDFKNVSIVGHYIKERTKNAQFIVISLRNNMFELADRLVGIYKTHNCSKTVSINPRKLAAQQPPLTEQQQQQQQQQPVTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHW9</accession>
    <name>A0A913ZHW9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051378.1">
        <property type="nucleotide sequence ID" value="XM_038195450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195450.1">
        <property type="protein sequence ID" value="XP_038051378.1"/>
        <property type="gene ID" value="LOC119724408"/>
    </dbReference>
    <dbReference type="GeneID" id="119724408"/>
    <dbReference type="OMA" id="YAEGIIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140535">
        <property type="term" value="C:intracellular protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000002">
        <property type="entry name" value="Probable translation initiation factor eIF-2B subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="512" mass="56152" checksum="9A03E3960EF67470" modified="2023-02-22" version="1">MDNEVQSSAADSSPATDKEAKKLSKKERRQLRLKEQGKLDGAKSPAVGGASQGPQGGTSAAPETQGATKSKAELKAARRAKQEADREKKKLAGGSPAVAGGGSASVSDKQPKPRLSKSVSDSTASKKEPPRVSDDLQQDDPKVQKRRAKKLERHQIPQRVEHERKVSLFSHLDQYERQVSVTRGLSFASGGIHPAILRLGLQYAEGIICGANARCIAMLHAFKQVIADYTTPPQKELSRDLESKIKPYISFLNVCRPKSVSMGNAIKHLKLQISHIPQDMTDAKAKEHLYECIDNYVKEKILLAAVAISKDAIKKINDGDVILIYTCSSLIRQVLCDAHRAGKKFRVVIVDSRPKMEGIEAVRRLMKHGIKCTYILINAVSYMMQEVSKVFLGAHALLANGYVMSRVGSSVIATVAKAYNVPVLICCETYKFSERVQTDSFVSNELGDPDDLVKTGKPTQYLSNWRDIQSLTLLNLVYDVTPPDFISMVITEIGMLPCTSVPVVLRVKSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJX5</accession>
    <name>A0A913ZJX5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052088.1">
        <property type="nucleotide sequence ID" value="XM_038196160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196160.1">
        <property type="protein sequence ID" value="XP_038052088.1"/>
        <property type="gene ID" value="LOC119724872"/>
    </dbReference>
    <dbReference type="GeneID" id="119724872"/>
    <dbReference type="OMA" id="CAVIRSD"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777865" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="160" mass="17702" checksum="AF3D66F920CCA31E" modified="2023-02-22" version="1">MHSSVFTIFACVSITFVAHVASEGCRPWNAGPPCPSKWHHRRASCYLITESTIKWSDARAECGNLGGVLAVPRSQEEHDFIMSFLPGYGGRAWIDCNDQTTEGIWGCTEGGVEVQYRNWDRGQAGKNAAEDCAVIRSDLLGWHDFPCHFLIPAVCKKPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK66</accession>
    <name>A0A913ZK66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051431.1">
        <property type="nucleotide sequence ID" value="XM_038195503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195503.1">
        <property type="protein sequence ID" value="XP_038051431.1"/>
        <property type="gene ID" value="LOC119724442"/>
    </dbReference>
    <dbReference type="GeneID" id="119724442"/>
    <dbReference type="OMA" id="NHETHAS"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="42189" checksum="8B03F6602956E4E7" modified="2023-02-22" version="1">MPAFDLNLTMVQNLTMASTIEAPSELHSYGVLVFVACVWIIVAVLGITGNTMVILTAILSEHIRTTTNVLVVNLSVADLWTCLSLPWSSVALLSNGTWPLASRIPCQIAAFMWHTGLGASLYNMALIALNRLVKITRPLATYNCIFSPRKMVFMVALSWLVPIFVIIFPLTIGVGGLGLDLRDKTCTDDDSHPRGDEYDLAQTIGFYPIPVTTVIISYAIIYVHVRRHFSKRNFKKKDPARDAVGLSAGMASMSMSTSAEAMEKREYHQGEERKRRISRQQLTITKNLFCVFCAFTLCISPYFISLFFAINRDVFALYGATILIFNSCVNPIIYGAKHPQFKKVLRPMLLCRWQKIPQPSHTLKAILSMRQRENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKK1</accession>
    <name>A0A913ZKK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038051575.1">
        <property type="nucleotide sequence ID" value="XM_038195647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051576.1">
        <property type="nucleotide sequence ID" value="XM_038195648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051577.1">
        <property type="nucleotide sequence ID" value="XM_038195649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195647.1">
        <property type="protein sequence ID" value="XP_038051575.1"/>
        <property type="gene ID" value="LOC119724547"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195648.1">
        <property type="protein sequence ID" value="XP_038051576.1"/>
        <property type="gene ID" value="LOC119724547"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195649.1">
        <property type="protein sequence ID" value="XP_038051577.1"/>
        <property type="gene ID" value="LOC119724547"/>
    </dbReference>
    <dbReference type="GeneID" id="119724547"/>
    <dbReference type="CTD" id="18400"/>
    <dbReference type="OMA" id="RLMKYPR"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17331">
        <property type="entry name" value="MFS_SLC22A18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="479" mass="51964" checksum="2C4A0BB8300A5514" modified="2023-02-22" version="1">MKLRSNRQTATEPAGQSRLRTSSSRQEPTEDMEDTTNHRRDTNGNHQNQEDKDWKQDKESGSSPEVTVMAPPSELLNGDDETKRDHNLSSPSWGVAKRVLHFNIFLYAACFWLQTGVLPYLTKKLGMDMAVYGYLQTFYNFIQLVGTPIYGRFGDLYGGRAALTLAYAMAASMYGLLGVATTGAFVFLSRVPALFLSANHGTQMVITDLTDDTQRAEALGRLGLSYGLGMIVGPLIGGMVTKYYSEQHAALVSCMGSLLSVLLVQLFIPVQTKKVATTKIQEEKSKSGVFSLEKYITLVTQTPGALFFLLVTMVSGLPNAIFQSMLPMILMEKFDLSAVYNGYVLSSLAIVSMLIQGLCIGPLTKRFSDMALLRASAVLLIVSFTVMAFAQNIVHLAIIMLPLTCGNSVIRIILNTVMTKIVSTTDTGTMLGLGSAGSSLVSIFAPTIGGILITQCGFFSFGVVGLVANAILLVILCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKX1</accession>
    <name>A0A913ZKX1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052448.1">
        <property type="nucleotide sequence ID" value="XM_038196520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196520.1">
        <property type="protein sequence ID" value="XP_038052448.1"/>
        <property type="gene ID" value="LOC119725159"/>
    </dbReference>
    <dbReference type="GeneID" id="119725159"/>
    <dbReference type="OMA" id="CGRKVIT"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="31416" checksum="886337873F26D022" modified="2023-02-22" version="1">MAEATAQTDLGEILLKEKWQLKEKFGKKGTGDGEFQFAAGVACFSNGDVVVTDGTEKRLSLFSSKGQYKTSVPQGPDRHQLENPRRVAVTRDDQLFVTDRKKVKVFDNELQFVREFTPSVDDAEELSKSNLRGIAVDKQRVAVADCGRKVITVHSLDGLLIASTSNNMVYCDLAMSNKERLIFTNYDEKKLLCVDFKGNEVFNVMPLLNGKPAKPTGVLCDDDGSIYVALHTGNWGNTEVHHYDSNGAFIATVAQGLYNPLGMAFTPAGDVVVADLHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLK6</accession>
    <name>A0A913ZLK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052214.1">
        <property type="nucleotide sequence ID" value="XM_038196286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196286.1">
        <property type="protein sequence ID" value="XP_038052214.1"/>
        <property type="gene ID" value="LOC119724954"/>
    </dbReference>
    <dbReference type="GeneID" id="119724954"/>
    <dbReference type="OMA" id="ICRMILC"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="72851" checksum="5FEF8F5178E68A0C" modified="2023-02-22" version="1">MHVVPFRGGAQPGQQQCSSLGRGQRYQQDYNRVDHNRPPSLNLASLQQNFNSLWDRTKKKVNKAYNIVYSPDPPSENYRVQEADGTEMGSLELSLRYPTGVHIGVEPETHHYNERLMEDGHDDDNDDVWTLLSMMHAMVVVTIVIVLDTAQIFLRYSEGVNAVTPAHVEGFFIMLYLISIAWILVVVVLKRPLPASDDEERTDAEAGSRYLYVGLLFFGIGGSLWMIMRTASYIEMSGKNCGNQSVFAFGSILCVVFTMLQIYYFWRFSKYCIVRWKPIAKLAVMHLMATNAALCVRTLVEETWEDFLLDYLKSSYAKHDAGYTGKLGHLVSAEGGNLYGKYNTTYNGTGGYPVDPCYIGKTADGLSGAVYKASVFLYSFTIEYTIIAGAMAYIMWQNIGRRVHHPHKEQTPRQFNFSFECGLLVGVLCTMCGVIILILNIIYLGDYEKRDQSFMSYRGYRVFLNLVCIIACIGAFIGIHKGGWQQDHHSGPAHRVDAALLLICVGGSLLQSTYTFVAAISSLGQLHAGLVFFDDFSHIIQTVLQCVLILDAMHRKPPADFRHTRTKQLLMFLLVANITWWLISTYELKGGYDLYALENGFYGATTWYVIVHLAAPLEILFRFHSTACFFEVWNLPGVDANAGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMK3</accession>
    <name>A0A913ZMK3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053038.1">
        <property type="nucleotide sequence ID" value="XM_038197110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197110.1">
        <property type="protein sequence ID" value="XP_038053038.1"/>
        <property type="gene ID" value="LOC119725627"/>
    </dbReference>
    <dbReference type="GeneID" id="119725627"/>
    <dbReference type="OMA" id="CGREKNR"/>
    <dbReference type="OrthoDB" id="10055077at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024868">
        <property type="entry name" value="FJX1/FJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147:SF5">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02072">
        <property type="entry name" value="4JOINTEDBOX1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037609957" evidence="2">
        <location>
            <begin position="28"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="640" mass="70837" checksum="75A90C61825C71D9" modified="2023-02-22" version="1">MSRRNAPFGGLFSVSFSLVVLLCRTHAIRGTEHAGDFRAQGRICLYVDLQQEFDRTVRAVKDVLDLSDSSHQEKLNHTIYKGLLNHVIGQSIPYPTEIQGGVPEADAAVVRELEEAGFVVLANLAKKDYSAPGGSASVITEPVSVEDDRPHPEVIPLSKLDGVVAGSPCDKISPHIEDGKNQGSLSEGPGPTSTHAQSRSCQTTQADLTRTKQDTPCAILREYTLQNPHSKEPTPGTPSIFGAQQNHPDYNLVLQTVSNSPPEGVRSSEASKPIRVGAAPEHGQLPSVNRDGRSRLVNREGVPIIEDDLYWSAEIDEATPKGVSQQELGEWKDRLSKQSVRSFEPGGLEKCGREKNRFIVLEDGTKLCARYRYPLITSMTGELYSYHLARMLGMTNLPPLHLSVATANSSFWRGQGSNFQDAEWDDGKVVMLTQWIEDLDKAFLPETLVQGPLPVTALNGGLRNLTTKELTSLLQWSDLLLFDYLIGHFDRLTINLSSVRFYNDSALLRSEVHNLVQHPHTKQLWIVDNESGLLDGYSFLSSSGSKDGLLQGELHEQLLRMTCVFRRSTADSVRALLADPEPARLLTARVLAQDPVSRGVFPEFDRIQKHAAMLRDRLTNIEDWMQECQRRNAAALGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNT7</accession>
    <name>A0A913ZNT7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053395.1">
        <property type="nucleotide sequence ID" value="XM_038197467.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053396.1">
        <property type="nucleotide sequence ID" value="XM_038197468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038053397.1">
        <property type="nucleotide sequence ID" value="XM_038197469.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197467.1">
        <property type="protein sequence ID" value="XP_038053395.1"/>
        <property type="gene ID" value="LOC119725873"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197468.1">
        <property type="protein sequence ID" value="XP_038053396.1"/>
        <property type="gene ID" value="LOC119725873"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197469.1">
        <property type="protein sequence ID" value="XP_038053397.1"/>
        <property type="gene ID" value="LOC119725873"/>
    </dbReference>
    <dbReference type="GeneID" id="119725873"/>
    <dbReference type="OMA" id="WDYEERI"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="BRD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056522">
        <property type="entry name" value="KIAA2026_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095:SF3">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23450">
        <property type="entry name" value="KIAA2026_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="361"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1683"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1741"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1818"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1859"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1478"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1749"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1777"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1819"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1874"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2542" mass="277931" checksum="A187BB89C183C0A4" modified="2023-02-22" version="1">MNPGMEPGIRDGSGIPRKKALLNGSLDDESLIPSQLIQETLALDERAPQIKCDVENPPIGAGNREDRLLLPKLSNQSKDEVIPQKIADSVSKPMPPDFFDSNPDSHLTLQRTAEKSVDDKNQIRNEIVVMEATSFKATTSNSPENQQSAPLDNPPTEPCPVDVRFQKSNLIQTCAENESDTKPFQLNTPHSAIDSNSEQDRVVDASIKPKEQPCNNTTPTTSSLTAPESSSNRCIESVEATGETGMDVLVEEYEEIVNESKNEVTRSSLLSMSPNSAFGETKSEQSETTNNSRATSRRDPLTSSSDSQRPTATDTASSSRSASSSQKSSSKLRGNAMIYVPYLSEELMQGYRILTEIFGDKCKSFVWPFLDPVDTDTLWDYESKIKHPMWLRKIESKFVNKEYQSITEFAVDIRQMLENCYRYNGIKHQISKYAQTLECVFEQKLALLSRPLQEKTTLYVTSDGKYNDGCPNTVELSSGRLRRTCTRLASRALEQKAAAPLAFHIKQELEQQEREEKRQKIVDRRDEIIKERQDLLEWDKQLIGETQWTYMKSIWEIPAIGHFLCLCQSSLELEEISFFELERSFAIPMESMILRRIFTTLLSTPYQRTRLGKKPPMPYKVWEARLREWVRGWYVVYNKLGDPTKVYEKIGVPERFFEVLGPHFPLDRVQYHELTYYERVWIMKALCDQLFETQMSIRRCVLAQPVEEQRPIILGVDGEANSYVHFPQFCGADLRIYRQSKYPDLLKKSKKDRVKTEEMEDPTEEQYTQRRKYRKGPAARKRIAKPKPVIVETPRSRPSRLRQRLTTTVHYGTYAESVISSTESEDVTSEFTEMEDEPESDSQSECQSTSNSQSECQAASNSQSECQVTSRSQSEGQTISGSQSKDCTTSNSQSEGHPTSNSQSKCPTTSDEPQEDAKPMDGVQEEEIVKDPKRDNGDSFNKSRANEECETVAEIQTGEEKHQPSHTTGVVKQEPTLTVESMDSRVDYLNAELKPSPTEQLCNGETTSSHSSTTSENISLEGHPKSYPEQETKDGIFKDAEKCRSPSFQNGTSSQGSDFSASAEHSIKTEGEAEAAAASEGSAVTEEPNTNNNSSQTLDIHHDMKLLAEPNDKPCGDTAPNAGDDTVPTAGDDTGPPASPPKPHVEVLPVLGEFELVCDSMESLKELVDKFGPPESKPLPPTTGRKRKATMYVKPPVRKRCEKELHEKLTNLLLELTPYEAKLAKFAIRNRERFKKEYEAAQTAPETDQDIKDIWASEESSSESASDAESESDEEAQPAKDNDEDWDACSEGMKLRKRSAKKSAAAAQDADEEAGETVQEDVPKKPKRPRPSGRRSPPHKNQLNTSLMGLFKSLSTDGLQDACKRLQTMIKRAESTRNHMFLKSKISPASLSGCGDGQAVMAFLNKFFWFGAKPPAVEGKVAKTVEELTSTYPTFVHNLIFRNIKSGLSKLANTAKSTSHDSTNQKNEPESKEESDIQSEPSQEAVQSQSTEGENMSDALTSSGRIETRSSVSNTSQENNSKLESNIKTKEVMDDFTLAGLYTVLSQTKGLLRERLATGLSELLPDYPNLQDSVVKIDQMVKNEHGDSVQPSLPSSRSETDKELLLKMLPKPSQYLRGSKSAAEGSAHVTHVKYISNEDIASMGSTIKPGNSLIVPVPTSKLPFMPKSRSKTETAKAAIPAIKPAHPITQATATTGSPQLSDNPGAVPHGVYTIKVDASVWSQLQGKPELQQQFVLQQIKEMQRKQTESGSSTDSTGSLNNPAQAVTCIRSPPKAQATVQKPSSQTRPTPARNTGRISQTTNLQNISDLSSLQPIKLSKPARPKASAKHHGGLPEPASNLSQKELIALLQQQQRQLQLHRQQQQEKQLLKQKNEQQPQQQQQTHTQQHAKQQFVLSASGALLLPPQPQQVTLTGMPKTPIVPGVGNTSQRVVPSCVQPSSAVNSSVQPTIAPSLASHATKLSTKTTVTAAVKQPKMTTNLNNPQPGAVASSATTILSQSGQQPQIIHRALVPQNPVLVSNPPKSPGSQLHLVQTNNGTQFVVRTGSLQAPRLQSQPSAGIIGNPRNTFPVVMAGQNSQAAAIGVTSANSTVLALPQTAQFLMQPSQAVPNTAKCQPQSVQGSCNSLLGQATTSVYLVGATQAGPQSNQDTPRRANNALTNQSVGQLAQPQRQTAPVVIQKPQLAVLKGLGDSKVIVGSPTKMVRLVHPSHLSTAATFVPTSVPGQVGSLPVVVTKAVQVAPQGVQVVGQAPAQQQLVHPPVQPGKMESVPSALVAQGSPSASGTIIQEHLHQVVLQQLAAGKLKLTPQTIPVSQIVHQVNQQQAPNQQPKAAQVVNTNPLVLSQQAPQLITKVQQSLPTTIKTSPPISGTDALFDRQLQASIKILSQAKTGQGSAVRLLAAPSMTNQGNLSGQEPQRLQLVSAASSVTGPACSLIQVPAVQNSPTQIAVQASHLVLAQPSLNNQAISPTVPTQFILQTESNQLMASPQNAVQKGVKRSSFAPVVASVVKVPRVTAPDQAATAQAVPATTFSGFPPNTTTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ60</accession>
    <name>A0A913ZQ60_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053206.1">
        <property type="nucleotide sequence ID" value="XM_038197278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197278.1">
        <property type="protein sequence ID" value="XP_038053206.1"/>
        <property type="gene ID" value="LOC119725729"/>
    </dbReference>
    <dbReference type="GeneID" id="119725729"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119482" checksum="AAA48CAB8521F817" modified="2023-02-22" version="1">MDVSQVPEKKANTLKEEHQQSGGGWHGLSSAQKRMVMMQQAAPESTAYVETIAVRTTNQIEPRDVFKTLTSLHPILTSKIDMDGNRKEFVVTLGSNVAFDVKPEVLDADIDVEDYIKQSTPVINIFHEPLVQYRYCIQGENHILVLHIHHLIVDIVTIINIWTDVHGLIEGASNVQGAPVSPTSYSSFVAWESTERQSARHGADQVFWKETFSSMPTRASLAVLPLSECEWSDASVYKARQAKIILPRESTESISKYCKSIGVTPFKYYLACTMLVYQRYIGTEDVTLAVPISTRPQAHQNTDGLFVNTVFFRKVLRTDMTFTDYVKDVAKSWMETYSHSQYPLEEVVKIVKEAHGMSMSSFCCMMFGSYTMQTSNVMRIPAKHAKMPVEFDVTFKRGEETIEIVVGWAEEFIDAGVAQRLAEGVVHTFCKAYQQADDVTQSIQVLSSAELDLLESFGRHPGKSQTIPEQPVHVAFEDHAVKNPELIAVSCRDVSLTYKQLNIMASSIAQGLLENTDQVTLQKRPVVIVMENDEYTVASVLGIWKAGGHFLPVAVSFQNLLKGIFERCEPATVLYNTRLKDLSIPTTKQCPVLNVKDLTTYPADDMVQSRLVGKTPVDNLAYVMRTSGSTGIPKQCSISHRSLGIVAAAYTKMYNLPDMTVNCLQWAPISFGVFIAILVRALVSSPGRLTICPDEFRLDVFHILDLIHEQNVNLVEFTPQLARHLVENAKLDQLESIQLLIIGSDVLQVHFYNRIKDLLNSNQRVLNGYGMTEATMDSSFFEGPVVSRTRSGMVPIGKPFPGVRYHVLNSSTLQPCPVGTVGELYISGDVLASGDAELVHLEHLQCVALKTGDAAYWLPTGDIDLMGRLNRMVKLRGLRIGTTEIENKILQLVPGVKAACVVPMTNSEESGSTDQSLCAFLVLDESSQTGGIEIDRRSVCQKLQGDLPNYMLPNIVSIIDEVPLTPNGKVNYKILPSINDIVKMETKKETTDNTVETKTASTLRMLLAEAMGFPDSSRIPSDTTFMELGAHSLVLVRFSVLLRQKTNFDVKVTDLFDYPSLRSLADYIEQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRH7</accession>
    <name>A0A913ZRH7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053691.1">
        <property type="nucleotide sequence ID" value="XM_038197763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197763.1">
        <property type="protein sequence ID" value="XP_038053691.1"/>
        <property type="gene ID" value="LOC119726150"/>
    </dbReference>
    <dbReference type="GeneID" id="119726150"/>
    <dbReference type="OMA" id="NIHHYSP"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="677" mass="75952" checksum="D9D0864DD586374C" modified="2023-02-22" version="1">MASSVTTQSVLEKISVDHLECSICTNRFGQPKLLDCLHSFCLQCLQGLRQSQDPSATKLTCPLCRCETMLKGSGVADLPNNFAFSAMVEEVTMQEKLLEGQGSEIKCQACDEENQAISRCMNCDHFLCQECHKAHGRMNLMMKSHKIYTLAQLRSGEIVYKSKLREQVPKCGEHPDQNLNVYCNTCEQAICTTCSVLDHAKHTLTGLPEAVEKCKKKVTEMVRKSERRKTELGTTIEDTCKSCKELETMFAKTQKKISKKAQQKITKLQQEITKLKQEVAKIQKEITKIQKEEKKLLKETDMIYKDKLKAFEAVQATNRKEVTQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDKLTFMDFEEGERSLGRLILEEEPKAAAKQSSRPARSCVKEKWKLKTELKKFGLIIGSLFSCKLLVSALSNNEILALRRFFGISALFTVSMPNGQHTPSPIPQRLQISGLTDDVRCIAVSRDDKLLAVDGQVVKVFNKQHQLLHQFTPGRGSDSQPTCLAVDDSNLIAVGYKEKKEISLHNPDGSLIRRLPAPMIGGYLTMYNHRLIYTNYGKKRLVCVDYYGASVFSVDMTSNIQGGNWHPDGVCCDSDGSIYVVVYGYPTGDILHYSPDGKYIGCVIKGCDDPRGMTFTSGGELVVAAGDSVKVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSB5</accession>
    <name>A0A913ZSB5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054522.1">
        <property type="nucleotide sequence ID" value="XM_038198594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSB5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198594.1">
        <property type="protein sequence ID" value="XP_038054522.1"/>
        <property type="gene ID" value="LOC119726752"/>
    </dbReference>
    <dbReference type="GeneID" id="119726752"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="165" mass="18377" checksum="1EF946303CA60EE8" modified="2023-02-22" version="1">MEEFKSNLPFLHLILSRSLTTKNGRHKTQIQDGQIGHLVPGLGIIIAMVAKMRTGRFKLIPALLGMSMYKNGCSAMLLNALSKTGLCHTSGTVRNIIDRYGVRYDQDIQAAKTEMEAKILHDTTKVIQLPPEETLDHSVGLPEWSFLTEDNPYDKTQGWVTPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT44</accession>
    <name>A0A913ZT44_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054604.1">
        <property type="nucleotide sequence ID" value="XM_038198676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198676.1">
        <property type="protein sequence ID" value="XP_038054604.1"/>
        <property type="gene ID" value="LOC119726816"/>
    </dbReference>
    <dbReference type="GeneID" id="119726816"/>
    <dbReference type="OMA" id="IGCINDC"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="670" mass="75046" checksum="70382B00FDE41EE7" modified="2023-02-22" version="1">MASNVTAQSVLQKISVDHLECSICTNHFRQPKLLDCLHSFCLQCLHGLRQSQDPSGTGTKLQCPLCRRETMLKGSGVADLPNNFAFSALVEEVTMQKKLLEGQGSDIKCQACDEENQAISRCMDCDHFLCQECQKAHGRMTVMKTHKIYTMAQLRSGEIVYKSKLREEVPKCGEHPDQNLNVYCNLCEQIICITCSVLDHAKHSLIGLTEAAEKCKKKVTEMVQKSESRKTELSTTIEETSKSQKELDTMFANTQNKISKKAQQEITKFKQEIAKIQKEEQKLLKETDMIYKDKLKALEAAQATNSKEVSQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPQQVPDNFNFMDFEEGERSLGRLILEEPRAAEKLKLRPARSCVKEKWELKTEVKNFELPNAFITHVEALSNNKVMALSIKSNILFHKTNMSPTIHPIITVSLPGSQHERTPIPQRLQINGLTNVMCIAVSKDDKLLALDGPVVKVFNKQHQLLHQFTPGRGSDSQPTCLAVDDSNLIAVAYKGKNEISLHNPDGSLIRRLPAPRIANCLTMYNQCLIYSCYPTWFNKMLLCVDYYGASVFSVDMTSMQRGLFPSGVCCDSDGSIYVAVCGHPTGDILHYSPDGKYIGCVIKGCGSPRGITFTSDGDLVVAAGQSVKVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTQ5</accession>
    <name>A0A913ZTQ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054817.1">
        <property type="nucleotide sequence ID" value="XM_038198889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054819.1">
        <property type="nucleotide sequence ID" value="XM_038198891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054820.1">
        <property type="nucleotide sequence ID" value="XM_038198892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198889.1">
        <property type="protein sequence ID" value="XP_038054817.1"/>
        <property type="gene ID" value="LOC119727010"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198891.1">
        <property type="protein sequence ID" value="XP_038054819.1"/>
        <property type="gene ID" value="LOC119727010"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198892.1">
        <property type="protein sequence ID" value="XP_038054820.1"/>
        <property type="gene ID" value="LOC119727010"/>
    </dbReference>
    <dbReference type="GeneID" id="119727010"/>
    <dbReference type="OMA" id="RRCHETK"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20188">
        <property type="entry name" value="T-box_TBX2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000026">
        <property type="entry name" value="GD16690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000014">
        <property type="entry name" value="Optomotor-blind protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000022">
        <property type="entry name" value="T-box transcription factor TBX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="111"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="T-box" evidence="6">
        <location>
            <begin position="116"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="652" mass="71426" checksum="3221A212B91E28BD" modified="2023-02-22" version="1">MKQAELPSTFPAMAYAPILPPRLSDFSVNSLLTQPHFFPGVFRGHSLAGAPGASAGSMPAGFPVPKLSDLHNPYTALQADLLAAHNHRQTMQQIHGIEPQESDTDDPQVTLESKELWDQFHKRGTEMVITKSGRRMFPSFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPSTGEQWMQKTVSFHKLKLTNNISDKHGFQTILNSMHKYQPRFHIVKANDILKLPWSHFRTFVFRETDFIAVTAYQNEKVTQLKIDNNPFAKGFRDQGTGKREKRKYPSASYDLDHRDPDDGASDQEPEAGEVSTTNSEKHEDKVLSHHERDIAARLAADHDEVTELLRRRAENERRCHESKLEDVEMRDVSREKVPTLGDRHPHEDTAGHGGKSDTEDRITGSRKPETGRESDKSDLSSSSGPKSGGSPGSLLNPFHAAATGHGPHPPVVTPVYPTPHPFFLHPQMALPGSVANLGAMSHMIPFVSQSSGSYSPSSHHCLDVHSAFALSAHQSLLASQSSLAASGFGLYSDPSALSQAYASNACTGAIFSGHPRFRFSPYALPATSTTMVTTASPLASTLPYDNSLHSSSLLGHSATSPTISTSKSSSSPGASVVSSAASELQSIQRMVSGLEKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTU1</accession>
    <name>A0A913ZTU1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055017.1">
        <property type="nucleotide sequence ID" value="XM_038199089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTU1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199089.1">
        <property type="protein sequence ID" value="XP_038055017.1"/>
        <property type="gene ID" value="LOC119727223"/>
    </dbReference>
    <dbReference type="GeneID" id="119727223"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="58874" checksum="F481E75E05C3E727" modified="2023-02-22" version="1">MEEPFAQCDAMALSVPTKDHFSNLPNEMKVLVLQHLSAEDLCHVALCNRSLREAANYDALWRPLCREKRWEKFDAVVDLCVEPPFIPSSPQHGGDGGVGDSVTFAFDSVVTGSSWPGLVNTCKWKEIYMKARHLERNWKNNLYHVVSFEFGSAGYTKSSRKNDCSEPEVTVRGLAGEGNILAGALSNDTLHIWDISSGKRRHRIKVGIGRIDKALKMKNGVIAVGCRGGKIRTYCAQTGEQLQVMSGHRLDVSRLFFDGDTIISIAAELDGDMREVRADGDIRVWNAIDGTSRFVFESTSDDPFRCRPIGVDYFDKTVAGAYIDRKIRLWDAQSGVCKQTIVSDANYLISCHLGDGIVISAHWGNVMKIWNVESGECIRHFDVPGVDFEDWDPDDESSHFHFNGEFLLATSLSNVRLFNLDGKFIRDIISDDDIYKQYLLRINYVFGNKCIACDDCGRGPMYLWNIDDLNNVFHLVKCCMFVGDNAVWMSETKLAFVRYLEYDKDENKIQIPKIEVHHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUH0</accession>
    <name>A0A913ZUH0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055353.1">
        <property type="nucleotide sequence ID" value="XM_038199425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUH0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199425.1">
        <property type="protein sequence ID" value="XP_038055353.1"/>
        <property type="gene ID" value="LOC119727497"/>
    </dbReference>
    <dbReference type="GeneID" id="119727497"/>
    <dbReference type="OMA" id="SEACTHE"/>
    <dbReference type="OrthoDB" id="6158042at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037273546" description="YqaJ viral recombinase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22234" checksum="915815597867BD18" modified="2023-02-22" version="1">MSFTRLTTLLTFPLQTTLILNSDYADNNTATAITQEETEALEQATVQQANCNLWYKCREQRLTASQFGRVITRKKDVNTKFLTSLCKVCDAGQTEILEVKCPYSARDMTVAEAVDGNPNFYMAKSGNGLQLKKTHQYFHQVQGQLMVTGAPFCDFVVFTSKDIHVERIVPDTAVWEAMLSKLALFYKEHVTPFLANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUK9</accession>
    <name>A0A913ZUK9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 59</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055154.1">
        <property type="nucleotide sequence ID" value="XM_038199226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199226.1">
        <property type="protein sequence ID" value="XP_038055154.1"/>
        <property type="gene ID" value="LOC119727361"/>
    </dbReference>
    <dbReference type="GeneID" id="119727361"/>
    <dbReference type="CTD" id="55379"/>
    <dbReference type="OMA" id="CASVNTI"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF42">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33649" checksum="69F9D0B34A9A9A95" modified="2023-02-22" version="1">MGKESLRDHLDGNELDLSLSNLTKVPVKELAALPKATRLDLSCNQLTSLPDNFCTLTHIVKIDLSNNSLTCLPENIGNLQNLQHLDLLDNQLEHLPISFANLRNLRWLDLKDNDNLDKDLKRVAGDCLDDKQCRECAKRVVAYMSAIQTELETQKLKKLEKEKKKAAAREKKQEALRKEKQVQKQLERQKKTEEYEAAMAAKRRKEEKKERKNAKAAGQKANGVQHTPVKTKSGSSCLVVFITLCVTLVALGLGIYFFCESDKANALCVDLQWVIDTVVTTTKERTQQLRDKIASYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVT0</accession>
    <name>A0A913ZVT0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055642.1">
        <property type="nucleotide sequence ID" value="XM_038199714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVT0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199714.1">
        <property type="protein sequence ID" value="XP_038055642.1"/>
        <property type="gene ID" value="LOC119727697"/>
    </dbReference>
    <dbReference type="GeneID" id="119727697"/>
    <dbReference type="CTD" id="22880"/>
    <dbReference type="OMA" id="ILWNCLR"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16931">
        <property type="entry name" value="HATPase_MORC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056360">
        <property type="entry name" value="Chromo_MORC2_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041006">
        <property type="entry name" value="Morc_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337:SF3">
        <property type="entry name" value="MORC FAMILY CW-TYPE ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23337">
        <property type="entry name" value="ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23327">
        <property type="entry name" value="Chromo_MORC2_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17942">
        <property type="entry name" value="Morc6_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="9">
        <location>
            <begin position="497"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="819"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119710" checksum="14DB78B3A5C49594" modified="2023-02-22" version="1">MVVYQGLSRAQLSFDYLHTNSTTHEFLFGALAELLDNARDARARRMDVFTEKDETLRGGYMLCFLDDGTGMDPAEVATVIQFGKSTKRMMESNMIGQYGNGLKSGAMRIGKDFLLFTKQGATMSCLFLSRTFHEEEKIEEVIVPMPSFEKNTRHPFGQSSDEKQRHKIEMDLIYKYSPFKTEEEFFAQFDRIEGDSGTLVIIYHMKLMDNGDSELDISTDASDILLAGTVSNTGVLDDSLVPERQSFRAYTSILYGEPKMKIYIQGHKVHTRRLAYTLYKPKLYKYTSTRFKTRSELKTSEAVHQAKVANEKAREAESKARDLEKKHGQGGPKDKRAMTRQAQTEAFELRQRANIMKKISEKQQKSLKEPKTINFHFGINLSNRRYDGVFIYNCGRLIKMYERVGPQVDGGVQCSGIVGFVDVPYLVLEPTHNKQDFADAKEYRHLLKAMGEHMIQYWKDINIASLGVTKFWENFGYVSHNWKDPPSDDPKFVRKRAMQTPVLVQCDACLKWRIMPFSSSNINRVFSDDWQCSMNTDSTHNRCSSAEQKVPIATGVFKKEVKSAEEQKKEILEDIKKKQEKLGKIEREKKRSSWSHFADDDFEEPYQYRERRTSLPSSTPPKPIGKASPVQSYKEKPTSRPIGKASPVVNQQQSRRLSAQSTASSNKPATATVSRYTTPAAKNDNKKTAPIVERKAASRPQKTAPPAPIAKKVYATKRQISSSTTSAAEAKNEDKAPEPAKKRRLTGNSQISTDEEMDVGKDEESSDSTLPSCDMQLESESVGKRVEARVDGKWYAGKVVKVFQKQDCVKWKVKFDQHPKDKYDKSFDKNSEDIRPIQEPPASATDDQSESPEAVPADIPPELPEPAPTTREPAVQKVTPTTTALPTAVTPPQDTAPPTTPRTTPKTTPKTTTSATPQAAVPPSKAAVTPSDNTEELEENLKDERLSQGFRKCLRYFLPPLWPMNKEMINNLSVEELSEFPLDNFFDQYEKGLRNLVGGFQAEAAEKARETEATKIKLAELRKLIAQLLRSINDEIVVSDTAGEEVDVMLAACVKQAMQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW86</accession>
    <name>A0A913ZW86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055784.1">
        <property type="nucleotide sequence ID" value="XM_038199856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199856.1">
        <property type="protein sequence ID" value="XP_038055784.1"/>
        <property type="gene ID" value="LOC119727792"/>
    </dbReference>
    <dbReference type="GeneID" id="119727792"/>
    <dbReference type="OMA" id="ANTTNWW"/>
    <dbReference type="OrthoDB" id="6782814at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="329" mass="37471" checksum="B00A7A751F98E5EF" modified="2023-02-22" version="1">MEQNIRCGRSFPTGDPHVIISTDASNEGWGASLPPRQAAGTWDDNTRSLHINVLELQAVVNALHHFQADVVGRSVLIKTDNTTVVAYINKQGGTISPQLCYWTWEMFQWLIRHKVDLRAIHIPSAENDIADSFSRGKVVPTEWSLNRRIVRQIFSILGRPHIDLFASAVNTQLPVFCSRAHHPHAWASDAIDWTNMFAYAFPPISILTKVIGKLERDRCKMLLIAPFWPRQPWFPRLVRLLVGSPLILPDRHDLLVQPQSRFRHPSPGDLHLTCWPLSSVPTEQQVFLKTLQLWPQRDVVSQHDKSMTVDYDIIVGGAQNRLWICSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWU3</accession>
    <name>A0A913ZWU3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056118.1">
        <property type="nucleotide sequence ID" value="XM_038200190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWU3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200190.1">
        <property type="protein sequence ID" value="XP_038056118.1"/>
        <property type="gene ID" value="LOC119728079"/>
    </dbReference>
    <dbReference type="GeneID" id="119728079"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="147" mass="16880" checksum="67A2655D7BCD6A80" modified="2023-02-22" version="1">MSKTIPVAKKKRERKSPCLTFEQNAKRQKSSEPPSCEQMNLTAPANKAIERAGNPEVPVPSKNPISSDDESMGSKSDIENEEIEDPIEHQAVKEIEDEMEVQSTGEEIDRKVKPKKARLSQTQYILRDQNPHKQDDRRLKRYPNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYF3</accession>
    <name>A0A913ZYF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056592.1">
        <property type="nucleotide sequence ID" value="XM_038200664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200664.1">
        <property type="protein sequence ID" value="XP_038056592.1"/>
        <property type="gene ID" value="LOC119728432"/>
    </dbReference>
    <dbReference type="GeneID" id="119728432"/>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="154" mass="16190" checksum="1F62B90F6F60E261" modified="2023-02-22" version="1">MAASSASTQAARQVWKMIVSGKRFENVLSKVNITSASPGQCSCELTVAEEQANRRGSLHGGFVSTLVDTLTTVAVLSSPAGVPGVSVELSVSFLKAARIGDQLTMDAEVIKAGKSLAFSKANLFNANGDIIAQGNHVKHVGRKNTVEDFIDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ17</accession>
    <name>A0A913ZZ17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056306.1">
        <property type="nucleotide sequence ID" value="XM_038200378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200378.1">
        <property type="protein sequence ID" value="XP_038056306.1"/>
        <property type="gene ID" value="LOC119728224"/>
    </dbReference>
    <dbReference type="GeneID" id="119728224"/>
    <dbReference type="OMA" id="NCFFNTE"/>
    <dbReference type="OrthoDB" id="547291at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037725274" description="SRCR domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="143"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="40736" checksum="EF79EC246AA73AD0" modified="2023-02-22" version="1">MATSISQLVLIFLVASITSVYGYKDGDVKFLKDDGSKLNSEYEGVVQMYRDGTWGGVCYDGTIPEFTAKYICRALGFEFVTRWVNARDAFPKNDNNEVTVNHIDCSGAADLSGCTKDWSDDRPTCEITNLLALACSPRTDYAVRLMGGSTWYEGRVEVYHEGSGSGHHHWGLVCDDYWGKSDAKVVCRQLGYGDPDKARYTDGDKYKSGSSGMPTLLDNVHCSGSEKSLAYCAGNNWHSENCFFNTELAAVICETASKTGVLSTAAIAGIVIGSLVILGFIVVLFCIYYRQSKMRKRNSRQAAVGNTGVGHGGVTYVNQGGMGAGGVTFITPGQGQQQVQYVMPGAAPAFNPPPYSPPGAAYGGDGGNKHDSANPGPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A151</accession>
    <name>A0A914A151_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serotonin N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aralkylamine N-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55469"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77827"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038057333.1">
        <property type="nucleotide sequence ID" value="XM_038201405.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057334.1">
        <property type="nucleotide sequence ID" value="XM_038201406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057335.1">
        <property type="nucleotide sequence ID" value="XM_038201407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057336.1">
        <property type="nucleotide sequence ID" value="XM_038201408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057337.1">
        <property type="nucleotide sequence ID" value="XM_038201409.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057338.1">
        <property type="nucleotide sequence ID" value="XM_038201410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057339.1">
        <property type="nucleotide sequence ID" value="XM_038201411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057340.1">
        <property type="nucleotide sequence ID" value="XM_038201412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A151"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201405.1">
        <property type="protein sequence ID" value="XP_038057333.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201406.1">
        <property type="protein sequence ID" value="XP_038057334.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201407.1">
        <property type="protein sequence ID" value="XP_038057335.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201408.1">
        <property type="protein sequence ID" value="XP_038057336.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201409.1">
        <property type="protein sequence ID" value="XP_038057337.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201410.1">
        <property type="protein sequence ID" value="XP_038057338.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201411.1">
        <property type="protein sequence ID" value="XP_038057339.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201412.1">
        <property type="protein sequence ID" value="XP_038057340.1"/>
        <property type="gene ID" value="LOC119728951"/>
    </dbReference>
    <dbReference type="GeneID" id="119728951"/>
    <dbReference type="OMA" id="IHLMCKE"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="171" mass="19483" checksum="0E97442C6A3ADDAF" modified="2023-02-22" version="1">MENMASPDVCIRKVTEQEVHDAWLIGSLSFPSDETASEERCKFRQREAPDLFWGYYESGKLISITHGTRTLKNELTHESMYTNDPEGTVVCVHSLCTHPEHRGKGVATALMKHLIQHVRDNLVNVTKICLLCHDFLVAFYESVGFQCLGLSQVTFGQMPWYNMVCNIQTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A176</accession>
    <name>A0A914A176_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057368.1">
        <property type="nucleotide sequence ID" value="XM_038201440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057369.1">
        <property type="nucleotide sequence ID" value="XM_038201441.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057370.1">
        <property type="nucleotide sequence ID" value="XM_038201442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057371.1">
        <property type="nucleotide sequence ID" value="XM_038201443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A176"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201440.1">
        <property type="protein sequence ID" value="XP_038057368.1"/>
        <property type="gene ID" value="LOC119728975"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201441.1">
        <property type="protein sequence ID" value="XP_038057369.1"/>
        <property type="gene ID" value="LOC119728975"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201442.1">
        <property type="protein sequence ID" value="XP_038057370.1"/>
        <property type="gene ID" value="LOC119728975"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201443.1">
        <property type="protein sequence ID" value="XP_038057371.1"/>
        <property type="gene ID" value="LOC119728975"/>
    </dbReference>
    <dbReference type="GeneID" id="119728975"/>
    <dbReference type="OMA" id="LQYRECT"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="24650" checksum="6807CBDDBF9ABEE1" modified="2023-02-22" version="1">MPPKKLAANKSASTKPATKKAAASKQPSNKPATKTTATKTNATIKDPATAKKEEAVKEPVDLGVTIKLGELTNELLGEEASYKKSGRWPLVLDPTGNSATFLKYRNTNMLNAKTPNDLVSNTIRLAVLGGLRYGKPVVLDMEDADMFDVCVTKFDEVQKELMDDILSKEITKNEKYLSLVKDTDGPEYSPDRFLSEVDKFVFVIITKIAPPASLRKRTFVVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5N5</accession>
    <name>A0A914A5N5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058721.1">
        <property type="nucleotide sequence ID" value="XM_038202793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5N5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202793.1">
        <property type="protein sequence ID" value="XP_038058721.1"/>
        <property type="gene ID" value="LOC119730002"/>
    </dbReference>
    <dbReference type="GeneID" id="119730002"/>
    <dbReference type="OMA" id="EDWEYNT"/>
    <dbReference type="OrthoDB" id="6275059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29560" checksum="0E7D34057EC6DD9C" modified="2023-02-22" version="1">MAVLILVNGFQGDHCGNRKHISIAADNRALQTFTFREEQIKSAVRCVSYCHADNNCRSVNYHKTDQLCQMNNLTRMQYPADFFTHYGSVYFDDDVHTSLFSVPQFRGCDEVLQAGHNVSGIYTIIPAGFNDGLQVYCDMETDGGGWIVIQRRQDGSVDFSRNWADYQVGFGSLSGEFWLGNDNLRSLTETEGKWQLRIDLEDWEYNTAWAEYDDFQIRGDNYKLRIDSYNSYSTAGDSLTRHNKMMFSTKDRDNDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8J5</accession>
    <name>A0A914A8J5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059751.1">
        <property type="nucleotide sequence ID" value="XM_038203823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203823.1">
        <property type="protein sequence ID" value="XP_038059751.1"/>
        <property type="gene ID" value="LOC119730793"/>
    </dbReference>
    <dbReference type="GeneID" id="119730793"/>
    <dbReference type="OMA" id="VELHCKH"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16532">
        <property type="entry name" value="RING-HC_RNFT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF0">
        <property type="entry name" value="LP20373P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="42449" checksum="89ACDB506C5D8B7F" modified="2023-02-22" version="1">MAASGEQRPLSDRLENVLQGIIPGLGTMEDPPRPPGGGGQGRDAIIIDMPAVNPEEENRNGAGNQNDGAGDTSEGENGDRQGGLAEGQFRALRPLMERTLPFVLILLLKILYDHRIGVIVLIGMGAAFFHFNGKLKEQVAQRDKRNLKSLLFMSLLLPFNIAVVYYVFADQQLPKCLIFLKPNFEKMDFWTLLWVIGITDYVIKYITIATKCLVTALPRVCLSFKRRGRVFLCIENISQLYRSLTPVPVWTAFLSEDTDSHWLFSYALVLLYIMAKSYMTYSKIFECYTTVKNVFKDSQYGSRPSSDHIQGVGEACPICQDNFTNPVELHCKHIFCEECVTMWFDRERTCPMCRAKVADSPQWRDGSTTSIIQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAF4</accession>
    <name>A0A914AAF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060416.1">
        <property type="nucleotide sequence ID" value="XM_038204488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204488.1">
        <property type="protein sequence ID" value="XP_038060416.1"/>
        <property type="gene ID" value="LOC119731327"/>
    </dbReference>
    <dbReference type="GeneID" id="119731327"/>
    <dbReference type="OMA" id="RYNDRNF"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000022">
        <property type="entry name" value="Matrix metalloproteinase 1, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037493331" description="Peptidase metallopeptidase domain-containing protein" evidence="16">
        <location>
            <begin position="22"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="17">
        <location>
            <begin position="107"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="428"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="514" mass="56505" checksum="AC50D048269B622C" modified="2023-02-22" version="1">MTGLTLLLTALLASAVTVIHSRPVENDFDAMTYLSYFGYLKRQTNDGTGMDEDEVRQGILDFQFMGNLTQTGVLDAPTMEKMNMPRCGMPDNIGHAMDARRKKRFSLGSKWRNTDLTFRIDNTTPDIPNRADVDATMVAALKVWSDVTPLTFTRVTGNTPADIVISFSPTDRDHGDGNPFDGPSGVLAHAFFPENGDAHFDEGERWTINSFSGINLFQVAAHEFGHSLGLGHSNVQGALMEAFYAGYVPNFQLHSDDILGIQAHYGIGSGGPDVTMAPNPPAPDIPCTGRVDAVTTTRDQSTYIFEGSNVWKFEMGASRISAGFPKSISSTFVGVPDNIDAAFYYPMYRSTFIFKGSQYWRFDNEVMDANFPRSITGDWGLPGDLDAAFVWSGNNQVYFIKGNEYYRYNGRAVDANYPRDLSVWNVPGNQVTAAVQWTNRVTYFFTPSGGYYRYNDRNFRVEGGRGYPAPVASDWQGCANTIEAATPTADSGVSGLAPSLLAMMLPVVLGTTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABZ7</accession>
    <name>A0A914ABZ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061440.1">
        <property type="nucleotide sequence ID" value="XM_038205512.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061441.1">
        <property type="nucleotide sequence ID" value="XM_038205513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205512.1">
        <property type="protein sequence ID" value="XP_038061440.1"/>
        <property type="gene ID" value="LOC119732121"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205513.1">
        <property type="protein sequence ID" value="XP_038061441.1"/>
        <property type="gene ID" value="LOC119732121"/>
    </dbReference>
    <dbReference type="GeneID" id="119732121"/>
    <dbReference type="OMA" id="FLTQLYW"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000622">
        <property type="entry name" value="ATP-binding cassette sub-family G member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="41"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="660" mass="73666" checksum="D85CB75AE45C1CEA" modified="2023-02-22" version="1">MDSTVPNGGTSPVSGPNSVSVAISYEQELKNKELQVSGSTISFHDINCEVDIKVKRKKTTKHILSDINGVFQPGMNAILGPTGSGKTSLLDILARRKDPKGLTGTVLVDGAPQPSNFKCVSGYVVQDDVVMGTLTVRENLTFSAALRLQDDISHEERKERVEDVIMELGLTDCANTRIGTDFIRGVSGGERKRTNIGMELITRPTVLFLDEPTTGLDASTASAVMLVLKSLSKRGRTVIFSIHQPRFSIYRLFDKLHLLSKGETVYHGPAEGALQYFESIGFQCEEHNNPPDFFLDVINGYFGAPSFEMPSRASALTDGKENHHAEKSTQVVLNEMDQPSLRSLYRQSDVHAEMMREAGEIYSVHRNGDEDIAVPSIQYATSFITQLRYVSKRTLINFLRNPQLSVFQPLTVVFLAIILGLIYWQIDTSLNSGIQNRVGAFLFVTMNMVFGNMSAIEIFIKERVIFIHETASGYYRVSTFFFSKIVCDLLPMRFIPTFLFSLITYWMLGLKSTAGAYFVYLLNLTLVTFTACGLAFFISCCVTLQSVATLLISMTFVIMLVFSGLLVNIASLPSWIQWIQYFSFFRYSLNALSINELVGLTFSDEANNATMRITGESYLEGQGIDYSTWGLWQNELALAIMCVGFMTLAYIKLRLIPKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEU9</accession>
    <name>A0A914AEU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062287.1">
        <property type="nucleotide sequence ID" value="XM_038206359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206359.1">
        <property type="protein sequence ID" value="XP_038062287.1"/>
        <property type="gene ID" value="LOC119732715"/>
    </dbReference>
    <dbReference type="GeneID" id="119732715"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="159"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="607"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="91807" checksum="FF60864DEA5374FC" modified="2023-02-22" version="1">MNIASSMLRGNKMVKYQRSSLSGADELSDHDQATVTALPNSQPAAHNQNSTASGLAEGDSSNGKMGENNCTKVPDVHYKNSNANNIKYIKGEMGGPSGKLSGRTLLEKILVVLCVVLLLVVLILAILYAIERQEEFCLTGPCVTIAGSVLSSMDKSIDPCDDFHKYSCGSWIKEHPIPDGQSRWTTFGMIWRENQVVIKQVLEGELNTTSTAEKKAQNYYTSCIDKEDSIDRLGAQPLIDIINTLGGWNVTGTFNLTNYNFNKVFQKMEALYDEKPFFTLLIGGDDKNSSINILQIAEGSILLPDESYMVNKTEDDPVVGAYFKYMRRVTELIGAEGEEVDRQLRNIWETGVDIANLSVSLDDYESYEDMLNYMTVEDMQREFPAFNWLEYLTYLFKDTEVKITSKEQLIVFTPKYLAAVSDLVLNTDPVALHNYMIWSLITSYTKYLSEDFRRAEDDFDKELYGQTTEQPKWRSCISDTDDNLGFALGALFVKETFKGKSKERASAMVEEIRSAFKNNLPDLEWMDEETRHAARDKANAILDLIGFPDYILNSAKLDSSYADLEINATDYFGNNIRISQFHTRQELQELRKRVNRGQWEMTPPQVNAYYSPPKNEIVFPAGVLQAPFYDKDYPKSLNFGGMGVIMGHEITHGFDDSGRKYDKFGNVKQWWNNATIDRFENQIQCMVDQYSKYEVNGNFIDGKMTLGENIADNGGLKSAYRGYQDWIKEHGEEKPLPALGLSHRQLFFVGFAQVWCSSQTAKEAQLQLVTDNHSPARYRVIGTLSNSEDFAREFNCPAGSPMNPKKKCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFJ6</accession>
    <name>A0A914AFJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062512.1">
        <property type="nucleotide sequence ID" value="XM_038206584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206584.1">
        <property type="protein sequence ID" value="XP_038062512.1"/>
        <property type="gene ID" value="LOC119733000"/>
    </dbReference>
    <dbReference type="GeneID" id="119733000"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="48922" checksum="BFB2DB08B502DE71" modified="2023-02-22" version="1">MPPKPRKSTNNVFGASGYLQKSIRHRIPCPTFRPTERLAGVIWYQGSIVNDTSTVRLISRDLQWSHTKDLPADERYSMSSDHGLVIDGVEDRDEGGFLCQVIPQTTDVRVGRVYVQVIGDTFPGGRSQVFSTVSFHRGRRQTLPCECASQTPDAPISVVYWSTGEGVTTDTQIIGARFSDGATLKVGHGADYSIGSDASLIVNSLHDVQDTQRFWCHEFKSDGTLRNCNVDVQISDQQTPNHALKASSTSFHILEGGEQSLPCSSWIPGVATCEVLWFKIDRAGRHFLLSSNDVDAESEYEFASDFGLIIKSVDDEDAGRYRCDTGGGISEVDIDVRVIAFLRYEIGSPVTVFWSFANPDNHTTTTVIGRLNLPGSSNTMSDLIGNACFSISEEGALLLNMCFQEDDVRYWCHVFPEDEILMRSYVDVLIKGCPTFKPWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG04</accession>
    <name>A0A914AG04_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062899.1">
        <property type="nucleotide sequence ID" value="XM_038206971.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038062900.1">
        <property type="nucleotide sequence ID" value="XM_038206972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206971.1">
        <property type="protein sequence ID" value="XP_038062899.1"/>
        <property type="gene ID" value="LOC119733392"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206972.1">
        <property type="protein sequence ID" value="XP_038062900.1"/>
        <property type="gene ID" value="LOC119733392"/>
    </dbReference>
    <dbReference type="GeneID" id="119733392"/>
    <dbReference type="OMA" id="YGHIHHY"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF50">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="42457" checksum="34DE55D3401DC152" modified="2023-02-22" version="1">MPKANRSASAQASGKGKDARKLRRSPRLCAIQSGVRGRQSQLEDVTTPEVGCQQQGWDRAEEPKLDQVPGPSRGSGPRQRRIQAKSQTPPQIDPKLSYLSFTPGQRIGDINLGKLAVKGKWEMLREFGKRGSGPGKFDGVVDITATQPGEIAVADYRNKRVVICSNEGQHKGTIPLQRPLAVAAIHNPEQRLLVLEDGSKYVKVFNMKDNTLDFKFPTVAPSEVEETQVNLKSTTVRTNGIILVGDIERMVWTEHRPTDGEILHTIPVQTPPQFLAVDDDTDRVVVSGFHTKKVDITDCKGSIHTTIKPTINGGPVWCDGVCCDSSGIYLAVDQGAAGTGHIHHYDQDGRFLDCVDQGLCFPLGITFTSNGQLAVAEHYFIKMYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG38</accession>
    <name>A0A914AG38_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062481.1">
        <property type="nucleotide sequence ID" value="XM_038206553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206553.1">
        <property type="protein sequence ID" value="XP_038062481.1"/>
        <property type="gene ID" value="LOC119732969"/>
    </dbReference>
    <dbReference type="GeneID" id="119732969"/>
    <dbReference type="OMA" id="DSYGCVR"/>
    <dbReference type="OrthoDB" id="8196415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF22">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="584" mass="65924" checksum="2A284B1584B33AE8" modified="2023-02-22" version="1">MLYLCTKVMVCLSFHYIMPYIDGCRFQNMDFIKLEIQSVLPTLPEPLLLAVVDKVTESGVEGVQDLQFIEESDLAELLKPVQSRKLMRAWKAKGNDQSSGVSVVQNDVPVTPPAGAELPQHDYHQASTSTAGASTSWSITPPVQMCVPPNWSETMDIPWSKMPVGITQAVKNAKRPSPADRRKMVRKTVECMQNFQLNPTKSQCSTVARRIVSKHPNSFADVTDKGEKLGSGYYSLLMQLKTRVEHVNRDNTMARIRKRRKSVQQAGEGAPARNVPVDTYGCVNWQPEEMPDDENEESLEAKRSALEELFNQHGPAPSGTSEKKIDDTMSLTYFLLRQHINNKDPVPSISELKQKWPFLFVPRCFFAHFKCLTGIEIVTRLYEAFQSKGKRIQGYMEHQNEQVRKQVKNVLADIQSALPEVDDEHQVLYPGVILLMMAYFEEPEDSLFMLADVTATAAEIEALPDLPNTPRLIMKGNSILTALKWMLCIEGKVVCASSSTDFMTGLAFLFGSYYILNLEYQAEAATTLEFIQRCFMRINPESGSKCTAKGKSKRTGQEVQRKRELINCRVATFVRKLADHEWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG80</accession>
    <name>A0A914AG80_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062521.1">
        <property type="nucleotide sequence ID" value="XM_038206593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG80"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206593.1">
        <property type="protein sequence ID" value="XP_038062521.1"/>
        <property type="gene ID" value="LOC119733012"/>
    </dbReference>
    <dbReference type="GeneID" id="119733012"/>
    <dbReference type="OMA" id="ECPLGIC"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="641" mass="71422" checksum="C4A9BB16380C2CEE" modified="2023-02-22" version="1">MATGPAVSSALETISRHHLECCICQERYQQPKILECLHSFCEQCLLKYCSTKHEGSTAIPCPVCRQETKLPEVRVQGLKTNFYLNGLVEEFELQEKVVCSGSKQLLCEVCEEESEATDHCMDCCKNMCSKCTKFHMKFAQLSVHVISSLDDIRKGKASSYQIKSKHQQISKCPIHVGEVTRFFCKTCETLICRDCTVIDHCKPEHSYIDRNLATSTYKQSLAELVSPLEKSMTELERSREKVSKMKEDLDVTVQRVMTEVQDRAAEIRAEVTAQENRILNDIKNIRTDREQKLDECEKTMGLAAERFQFSLDTAREVTRTASESDFLSLYATISKDLKLLAGQSMPRVDNRLAFLKFKQSQGVGGISLGEVVTEGKWELCREFGREGRGPGEFHGAWDITARQPDEIAVTDFLNNRVVICSIDGNQKSTIPMQGRPRGIAATRSDNRLVVVEVGASHVKVYNSDNTLAYKFPTVPPSEVVKTTVDLQSVAVKNDGTIAVGDVARMVLTVHSPTDGELLHTIPVKIKPHFLAFDSNDRAIISDYESQTVDIAGGNGTTKRTIKPTINGQPVRYCFSVCTDSSGIYVAMHNGGNTGHIHHYDSQGGFLQCIAQGLHYPRGITFSSDGQLAVADYSSVKMYHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH12</accession>
    <name>A0A914AH12_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062983.1">
        <property type="nucleotide sequence ID" value="XM_038207055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH12"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207055.1">
        <property type="protein sequence ID" value="XP_038062983.1"/>
        <property type="gene ID" value="LOC119733657"/>
    </dbReference>
    <dbReference type="GeneID" id="119733657"/>
    <dbReference type="OMA" id="HILYCAT"/>
    <dbReference type="OrthoDB" id="6601747at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36416" checksum="DABD0DCD8E5F3AD7" modified="2023-02-22" version="1">MDAEAIADAIIETSVKFGLKTENLIGQGYDGCSTMAGKDNGVQTRIKSIPPKAAFVHCSSHRLNLVVTDLNSVPDVRNAIGTVKAVIKFFCDSPKRRKQVPNLQLLCETRWTAKYKSIRIFAENFVAIVKALENLSKNELETTRQTAHQLFCASTTANFLVTLRIIARYSALLEPITQSLKAVNLDLLGVQEHIQKLLNVLRSHRSESEQVFTQDIMPVVKQTAEELSIDLSLPRRCGRQMFRSNPDSNSFEDYFRKSVFIPYLDSILQSLQIRFGEDNKPHFSLFALHPAQLSKNDRTEIINIASKINSIYEIDNLESEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH43</accession>
    <name>A0A914AH43_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063305.1">
        <property type="nucleotide sequence ID" value="XM_038207377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207377.1">
        <property type="protein sequence ID" value="XP_038063305.1"/>
        <property type="gene ID" value="LOC119733994"/>
    </dbReference>
    <dbReference type="GeneID" id="119733994"/>
    <dbReference type="OMA" id="KQSWPEC"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000864">
        <property type="entry name" value="Prot_inh_pot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036354">
        <property type="entry name" value="Prot_inh_pot1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091">
        <property type="entry name" value="PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33091:SF29">
        <property type="entry name" value="SUBTILISIN INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00280">
        <property type="entry name" value="potato_inhibit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00292">
        <property type="entry name" value="POTATOINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54654">
        <property type="entry name" value="CI-2 family of serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00285">
        <property type="entry name" value="POTATO_INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037552731" evidence="4">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="99" mass="11077" checksum="2FA0C99B0EA9C784" modified="2023-02-22" version="1">MMAGKSTLMFCCTLVLLAVLVAEGCRQEGGISKRSRKERWPELVGQTGQRAKTVIEREDPTLQVEIVPYGQVVTADYNTNRVRIFLDRERRVAAPPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ70</accession>
    <name>A0A914AJ70_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064035.1">
        <property type="nucleotide sequence ID" value="XM_038208107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ70"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208107.1">
        <property type="protein sequence ID" value="XP_038064035.1"/>
        <property type="gene ID" value="LOC119734571"/>
    </dbReference>
    <dbReference type="GeneID" id="119734571"/>
    <dbReference type="CTD" id="79831"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056520">
        <property type="entry name" value="ARM_KDM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24472">
        <property type="entry name" value="ARM_KDM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DM8" evidence="12">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin-like" evidence="11">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="40355" checksum="36E3B8CE09FF8AB9" modified="2023-02-22" version="1">MEGFPMALRGVLPKNVKEMALEDLAQEVTGRALCLLLQECADDFFRGDIPQSLNKSEELLSYTWEKLNTGHWKDVDIAWRHVYTYASLLKAMGICRECEHEDRTEDAIQASYKKALEACDMGLLMGAPVLDNILSRFARAIQTTYKPLKPASCTSRILDQSVEPSLPPHQIPAISKQHEIPRVFCPSLLSFQSQYMQTKTPVIIQGAMEHWPALGLRKWSLDYLRQVAGSRTVPIELGAKYTDEAWSQSLMTISDFISKYIEGKELSKRKGQVGYLAQHQLFYQADKDLPHYPKSLVLDPGPTRIFRGTRFTLARIQQAFYMGQALFTGKIQVWIRVERLYLGRNQKSTADFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJH2</accession>
    <name>A0A914AJH2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063564.1">
        <property type="nucleotide sequence ID" value="XM_038207636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207636.1">
        <property type="protein sequence ID" value="XP_038063564.1"/>
        <property type="gene ID" value="LOC119734258"/>
    </dbReference>
    <dbReference type="GeneID" id="119734258"/>
    <dbReference type="OMA" id="RSWRKPC"/>
    <dbReference type="OrthoDB" id="10280867at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038007914" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="104" mass="11503" checksum="85784CFB1BFBFE44" modified="2023-02-22" version="1">MTNYILFLGLVVAMFAILATSSDDAALNDEVQSPEDAEALSNFLDGLLQSRVDRSWRKPCDGNSCIQSGGRGWKRNRAPFSLDGFKCVGAGCDRGWKRTSERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK57</accession>
    <name>A0A914AK57_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063951.1">
        <property type="nucleotide sequence ID" value="XM_038208023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK57"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208023.1">
        <property type="protein sequence ID" value="XP_038063951.1"/>
        <property type="gene ID" value="LOC119734491"/>
    </dbReference>
    <dbReference type="GeneID" id="119734491"/>
    <dbReference type="OMA" id="PSHRENH"/>
    <dbReference type="OrthoDB" id="10455439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34438" checksum="F1A5E05742CA657F" modified="2023-02-22" version="1">MPHKMCIRHPAPRVADVKVYKGLTFATSISSKLHLDKVLQENSKLTKKKLQIMELQARLPLSVLLLSVVFVGLSASPVPINLLSRLRRSASTTTGTTLESSVPTTEESLSTVSASPSARVVRQARSADSLSMHYNLLHTEVHVVSREHQELYSNYKRERFGNDTDPIVRDMGLSYLPSVHDLAHEIVRSSLPDSELVTVHYNNLIIFRDTLARVRDSETRNVSERVDAVIRPLRLVINRLETTMILNGQEDSIIHVESSIPEFHSDVTIQERNMRTLFVLQEFHEYMPHVMHDYKKLAHRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKI7</accession>
    <name>A0A914AKI7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064086.1">
        <property type="nucleotide sequence ID" value="XM_038208158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208158.1">
        <property type="protein sequence ID" value="XP_038064086.1"/>
        <property type="gene ID" value="LOC119734623"/>
    </dbReference>
    <dbReference type="GeneID" id="119734623"/>
    <dbReference type="OMA" id="ITHIYIP"/>
    <dbReference type="OrthoDB" id="6097796at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037207258" evidence="6">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="251"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="424" mass="47467" checksum="794755C46E7506A6" modified="2023-02-22" version="1">MNRVISVLLVLVPAITAVGAVPWNDEARLVSDLWTNAGYDAETRPVRNASETVQVALRVDVFSILNVDSKEQEIRIASVFNMKWQDDRLKWNPDVYNGLEYLSVAADKTWYPKLRVLNALEESRLITDDTEVMITSEGVLHVLHSLIFEAQCHLQQALFPFDVQECQFLVGTVGVPSGVMRLEASEADKPRESVQSISSWHLDDLTVRGILSPTCIDAHAVADGEECHRTSETEVNLKLRREPKYHVYTVLAPCTILTLLASMIFWLPTECGEKLSFGISIFFGFVIFQLLVQDALSEAGGEKPSLLIRYVLFNFALVGVAVMISAVSIALYHRGDGGETSQSTALCKICAPHAQVGIEDPQQARLTQDREGDAAKDEEKPQSKAKKPWNWKKIAKYLDRVSFVVYYIAFFIFFLAIVVEVIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMG9</accession>
    <name>A0A914AMG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064624.1">
        <property type="nucleotide sequence ID" value="XM_038208696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208696.1">
        <property type="protein sequence ID" value="XP_038064624.1"/>
        <property type="gene ID" value="LOC119735017"/>
    </dbReference>
    <dbReference type="GeneID" id="119735017"/>
    <dbReference type="OMA" id="NDISHGT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037150113" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="120"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="37343" checksum="F1798094A1844622" modified="2023-02-22" version="1">MASFGIFAVLLIAINALATADVCYSGQQLGGSDGDDPQWVIPHSQPCKCTRILPGGVNVAKSQQGRLVQAPLSKTAIIAADEKSEILTALGCNKQSTEPLTPTLSQSITVVSNSNGNPELVPQNLGSYCPEYDNDISHGTGQTTATIYPLGIPTGINVLCELDSDGRGWIVFQRRNYTDWESRQVFNKTFEEYKNGFGSLTGDNFWWGNDNLATVTADGTWQLRVSLRLWDATNKVEEYRYATYFPFRVTSPEYTLSISNYYPSGNLSDILSNHHGMAFSTLDRGAGSACATQTGGGWWFQNVDCDEQINLNADTPCHAIECWLKIPAVLINCEMKIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMZ0</accession>
    <name>A0A914AMZ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065112.1">
        <property type="nucleotide sequence ID" value="XM_038209184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMZ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209184.1">
        <property type="protein sequence ID" value="XP_038065112.1"/>
        <property type="gene ID" value="LOC119735478"/>
    </dbReference>
    <dbReference type="GeneID" id="119735478"/>
    <dbReference type="OMA" id="EESSFAW"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999988" description="Farnesoic acid O-methyl transferase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="24615" checksum="E0F86DDE3B80DADD" modified="2023-02-22" version="1">MLVFSWTLGLLCSLSLLPVQGKMCSAMIKAAPGDDLTALRDNAFAAFRTECRGKQGNLDDTKSCSFTLEPSDPPVATFILQPLRAPFRLDFDVKTHRDAIIVLAEEKTEASVFAWITIGGWSRQRSAIRACFIFGSPECGQLLGGRSEHIEVDIVVDSESRPFWMEYKHGVVTVGKGGQEEAFLEWDAAAYHHRHISTPVYVGISSWTYVPADWVFYQFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANS0</accession>
    <name>A0A914ANS0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065079.1">
        <property type="nucleotide sequence ID" value="XM_038209151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANS0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209151.1">
        <property type="protein sequence ID" value="XP_038065079.1"/>
        <property type="gene ID" value="LOC119735452"/>
    </dbReference>
    <dbReference type="GeneID" id="119735452"/>
    <dbReference type="OMA" id="HINAMNI"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003851">
        <property type="term" value="F:N-acylsphingosine galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF54">
        <property type="entry name" value="2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037586140" description="Glucuronosyltransferase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62336" checksum="3A9FFAF6132E5579" modified="2023-02-22" version="1">MTSPDIRIHQLVILLVIFLLGGQCESTLTVQQTQLKLLYYTASDGGSHHLTSTKIAAALVRNRHDVTFLLSDSCTKWRNASGADMFRFAVHRSLYTAEERERNLRGMSRHALRGELRGAVNAMKFLLRLRYSAEYQGHRELFNFLWSECDSLLGDNATIHSLREESFDLLIGDDLSDCQPLLAEMLGIKFVLVSGTGITPSKASWHGIPNHPAYIPERQAGLTDTMSLPQRILNTCRYVVIGLARRVALWRFEDLQRKYNLSPEKRMAEMLAQAQLLLFYGDFGLEFARPLQPNTVMLASPMLGLPSNEKISVEQHTFLDDANEGVVLFTLGSHVKEVESAQAQMFANGLAKLKQRVIWHFPGSVTHLHIGNNTKVVQWMPQQEIMAHRNTKALLSHGGLNGMYEAAWYGLPMVGIPLFGDHFDNMEQAVAKGMALQLDIATLTEDALYDTVTRVIEDPRYRERAQHISRLLRDDPVIPSEKAAHWIAHVGKYGGEHLRPRAADLSWIQYHLLDVYVSLAAILFGVLGVLLLGCKGILWLACHNRRQQKTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASE4</accession>
    <name>A0A914ASE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066281.1">
        <property type="nucleotide sequence ID" value="XM_038210353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASE4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210353.1">
        <property type="protein sequence ID" value="XP_038066281.1"/>
        <property type="gene ID" value="LOC119736310"/>
    </dbReference>
    <dbReference type="GeneID" id="119736310"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="207"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="438" mass="46616" checksum="973B4DCD304C728C" modified="2023-02-22" version="1">MAKTEAPTAAPVASRWSRLLRRSVDGAPPQDPLTMADFMKVAKSKIDASAGELNTISQEIWSHPELNFNEHHAHEVLTDYLEKEGFNVERHFVLDTAFRATFGSDNAGPNICVICEYDALPEIGHACGHNLIAECGVAAGIGIKAALEASGNKYGKVTVLGTPGEEGGGGKKRLIKANAFVGIAVAMMAHPYRYNVPRPIALSMTALVIKFQGKASHAAAAPWDGNNALDAAVTCYQSISNMRQQMKPACRVHGIFTNGGAAPNIIPEEAELTYYLRAVDENELAVLKKKVEACAEGAAIATECKVEIDASGISYANLITNDGLSIMYEAHAQGMGVEFSHDEALRRGGSTDMGNVSYVVPSIQPKFTPGSGDAAIHTRPFASVAGAPEAQAPTLIQAKALAMTAIELLQPSGQDTLKKIQKEFKETVSKLPMPDMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASK4</accession>
    <name>A0A914ASK4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066331.1">
        <property type="nucleotide sequence ID" value="XM_038210403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210403.1">
        <property type="protein sequence ID" value="XP_038066331.1"/>
        <property type="gene ID" value="LOC119736387"/>
    </dbReference>
    <dbReference type="GeneID" id="119736387"/>
    <dbReference type="OMA" id="TTVICRM"/>
    <dbReference type="OrthoDB" id="10363087at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="50389" checksum="DB24BAA5062A7094" modified="2023-02-22" version="1">MGQTHAGNSITRRVKDENADQPRRRIKLAHRRHRLIARWSQYESSSEDDVFGSSRPRSVCDSEHGSVALKQLHKLSQSYPDKIDYGSNPILGSGDNCEALSVSEARSSRLSETTFSSAETLVADDESSTLKRVKYRSNEILFRSSKSLNEVSSVIRPLPTEDSAEVRVAEVKDSPESDVGPETEMVGDVARLTVLAEDTHESAISWKLGENEGEKRGREAEEATPKDGVSVEVSSVQDPSSIVPVPGSEEPNEHGIVIPANAIFGSSKRRKRTLTSRSRSYKLATDGMTTVSPAASPPTVPKRPSSRPPRPAEKSWLKTGHLAHQRRNFVQRENERNARQQQQAEEASIWGHRRTKSVAASHMVDRQTSLAACHRRAVSMRDSIVDNDRAYNLLRCLDSGLRLWCKLSSDGYDSSILISDKTGNLLEVADDTQTTVICRMGGSVRCRVDISEAICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATY4</accession>
    <name>A0A914ATY4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067133.1">
        <property type="nucleotide sequence ID" value="XM_038211205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211205.1">
        <property type="protein sequence ID" value="XP_038067133.1"/>
        <property type="gene ID" value="LOC119737106"/>
    </dbReference>
    <dbReference type="GeneID" id="119737106"/>
    <dbReference type="CTD" id="79661"/>
    <dbReference type="OMA" id="IMFEYKS"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000007">
        <property type="entry name" value="endonuclease 8-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015371">
        <property type="entry name" value="Endonuclease-VIII_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF27">
        <property type="entry name" value="ENDONUCLEASE 8-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09292">
        <property type="entry name" value="Neil1-DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="47833" checksum="4ABE856FB584C133" modified="2023-02-22" version="1">MPEGPELHLASRFVNRVCSGRVFTGKVVKSPVHKSDEVPFHAQSYIITAASRGKEMQLILSEIENPPKSKGRGKKPKNLANLKTMKILFRFGMSGKFQFTTVSEVHKHSHLQFFTNDDPAMVLSHVDVRRFGRWEVDAGWSKVRGPDPMFEYQLFRSNVVKNIKSSAFDRPICEVLLNQKYFNGIGNYLRAEILYRLSIAPFEKARNVLEGLNEDPPEVKPKVKGQEVKVKVEDPKVDILHLCHTVPLEVVNLGGGGYDPEGKSADYSKFNAWLQCYYQPDMNNLVDHNKRTIWFKGPVGPMAPKESKSRSPVKKRKKKETASANDEESPKKKAKAEEKAKVNTENKKKSPRKRPAKTQVSTPSRKSSKKTSVNAKKVENTPRQAKTQIPDAHEVKGYATRSKVTVNGMMKSKTPKKKTAKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUV7</accession>
    <name>A0A914AUV7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067076.1">
        <property type="nucleotide sequence ID" value="XM_038211148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211148.1">
        <property type="protein sequence ID" value="XP_038067076.1"/>
        <property type="gene ID" value="LOC119737071"/>
    </dbReference>
    <dbReference type="GeneID" id="119737071"/>
    <dbReference type="OMA" id="AHSMPQT"/>
    <dbReference type="OrthoDB" id="10059453at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="121" mass="13691" checksum="21AB81E65B4B40FA" modified="2023-02-22" version="1">MSKKSTPSKAGVTYRTSSRRNGWSCPPHPLQFVAWIFIAAFAVMFHGMAVPTIPYHWQPACHMIVGVVLAVHVITHLVCLTINPADPSTLRRDKKAMPEFDRTQHKHVIENNHCYLCEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUV9</accession>
    <name>A0A914AUV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038067298.1">
        <property type="nucleotide sequence ID" value="XM_038211370.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067373.1">
        <property type="nucleotide sequence ID" value="XM_038211445.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067455.1">
        <property type="nucleotide sequence ID" value="XM_038211527.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038067547.1">
        <property type="nucleotide sequence ID" value="XM_038211619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211370.1">
        <property type="protein sequence ID" value="XP_038067298.1"/>
        <property type="gene ID" value="LOC119737169"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211445.1">
        <property type="protein sequence ID" value="XP_038067373.1"/>
        <property type="gene ID" value="LOC119737169"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211527.1">
        <property type="protein sequence ID" value="XP_038067455.1"/>
        <property type="gene ID" value="LOC119737169"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211619.1">
        <property type="protein sequence ID" value="XP_038067547.1"/>
        <property type="gene ID" value="LOC119737169"/>
    </dbReference>
    <dbReference type="GeneID" id="119737169"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000001">
        <property type="entry name" value="X-ray repair cross-complementing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000080">
        <property type="entry name" value="X-ray repair-complementing defective repair in Chinese hamster cells 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="37"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="15">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="602" mass="67836" checksum="DF4D76A445290ACD" modified="2023-02-22" version="1">MSNWGNWGTSFGYADGSGDEDEDGDAGYQTAFSTKDGLIFLVDCGESMFQKAEPDEDSHFQLCVKCARSVLTNKIISSDKDMLGVVLFGTEKNKNSGNFEHVYVLQDLDNPSAARILELESLLEDDYDFKANFGHNAGFSLSDALWTCSNMFSQSTQKIGHKRVLLFTNNDDPHANDLAAQRQAKTKAKDLHEIGIDIELMHLAQPGKDFDHSKFYQDIVFSPDDEDLGVLPDPAEKFEELLNRVRAKDHKKRSLGRLNFNLGQGLDLGVGVYNLVRQQTKPYPVKLYKKTNEQLKSKSRMFCEDTGELLMPTDIKKYQMYGGRNIVFEKEEITEMKNFGESGLVLMGFKPRSSLKRYFHIRPSQFLFPDESVVKGSTSLFSALLQRCLARDVVAICRFIPRKNSTPFFVALCAQEEELDEHNVQVTPPGFHLIYLPNSEDIRKLTLPEQPRANVDQIDKAKEVIKKLQFKFKSENFENPVLQTHYRNLEALALDRDKPEDIVDHTAPDFAMITKRAGDKIEEFKDLVFPDGYVPGAKQRKVGGDSSRAKPTVDVDMNQYAQQGKLGKLTVAVLKEFCSKNGLSTAGKKNDLIKTVSGHFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVZ8</accession>
    <name>A0A914AVZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein preY, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PREY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067426.1">
        <property type="nucleotide sequence ID" value="XM_038211498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211498.1">
        <property type="protein sequence ID" value="XP_038067426.1"/>
        <property type="gene ID" value="LOC119737283"/>
    </dbReference>
    <dbReference type="GeneID" id="119737283"/>
    <dbReference type="OMA" id="MICRRAL"/>
    <dbReference type="OrthoDB" id="1884515at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505:SF4">
        <property type="entry name" value="PROTEIN PREY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505">
        <property type="entry name" value="ZGC:162634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="115" mass="12818" checksum="FE6B5504F03E0790" modified="2023-02-22" version="1">MAAPMRCLISRSSAFLFTKCVKTGVQVSSLRRFHLSSSVFYPAEFDPSILDTVVCPLSKSQLRYDVEASELVNDELGVAYKIIDGIPNLIPEDARMIKQDKDSADKNSDQTKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW88</accession>
    <name>A0A914AW88_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038068012.1">
        <property type="nucleotide sequence ID" value="XM_038212084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW88"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212084.1">
        <property type="protein sequence ID" value="XP_038068012.1"/>
        <property type="gene ID" value="LOC119737620"/>
    </dbReference>
    <dbReference type="GeneID" id="119737620"/>
    <dbReference type="CTD" id="55661"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000842">
        <property type="entry name" value="ATP-dependent RNA helicase DRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="239"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="425"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="651"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="796" mass="91387" checksum="40C7939169AC1847" modified="2023-02-22" version="1">MALPSDFIRTIQDDEEISVAYEDSSSDEEAVKPKKLSKLKRLKKGQEDFSQEFEFSERAFDEDSAWTPNLLKSLKPRGHTRIETNTSLEQKIARIRSEKRKKKESEELAEAKDNQSDSKEAKDQDQNGREVDGDHGNADDEDEEEEEEEEEDEDMGVEDMEWDQIKVKTTSEKRLKRKQQKDESDDSEDEEAKKAKFFAQAPEMTGYSSFQEMNLSRPLLKAISAMNFVKPTPIQAKTIPVALLGKDICACSATGTGKTAAFMLPVLERLLYKPKHSMTVTRVLVLVPTRELGVQVHTVTRELAQFSGVDCCLAVGGLDIKLQEAALRKGPDIVIATPGRLIDHLHNAPTFDLKDVEILILDEADRMLDEFFAEQMKEIIRLCSHSRQTMLFSATMTDEVKDLVAVSLRNPVKLFVNENTDVAYNLRQEFIRVRPNREGDREAIVAALCSRTFHDHCIMFVQTKVQAHRLHIILGLFGLNVGELHGNLSQAQRLEALRRFKEENIDVLVATDLAARGLDIEGVKTIINFTLPNTLKHYVHRVGRTARAGKSGRAVSLVGERERRLLKDIVKKANNPVKSRVVPQDVVQKYRDKIASMEEDIEEVMRLEEEEKEIRITELQMHKASAMLEHQKEIFSRPKRTWFQTHKERVQEMDKLQLQPGKMDKKSKKRAKKQQQQADEDPNDRRMQRELEKSQLFSKREAKRSHKGQVIRGFRNQDQSSENKKPFGKRGKGQGGQFKSSFDKELTSTNKRSVKQFRNKTHEARKDQKRNQKASSKPNKQNKSKSKPSKFNKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX18</accession>
    <name>A0A914AX18_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068670.1">
        <property type="nucleotide sequence ID" value="XM_038212742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212742.1">
        <property type="protein sequence ID" value="XP_038068670.1"/>
        <property type="gene ID" value="LOC119738026"/>
    </dbReference>
    <dbReference type="GeneID" id="119738026"/>
    <dbReference type="OMA" id="DARMSPC"/>
    <dbReference type="OrthoDB" id="10134841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999994" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="132" mass="14953" checksum="96AE0F0E43231585" modified="2023-02-22" version="1">MKSVILFVAVLALTSLTTGIETCPKWTTFSETMYSVCLSSKTYSWDMGMKYCYQDMVGSHLCTLKELAALYELGARDNHWGLTNGHDRDARMSPCGDYKGAECYNNGAPEPYFPNTPRPNSWDEVYCCKSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AX91</accession>
    <name>A0A914AX91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068755.1">
        <property type="nucleotide sequence ID" value="XM_038212827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AX91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212827.1">
        <property type="protein sequence ID" value="XP_038068755.1"/>
        <property type="gene ID" value="LOC119738093"/>
    </dbReference>
    <dbReference type="GeneID" id="119738093"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037125455" description="Sema domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="3">
        <location>
            <begin position="30"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="713" mass="79222" checksum="64AA27C5E844357C" modified="2023-02-22" version="1">MTMVHSHLIGWFLLQTLYFSSAEKDRFPRYPTVLYSETVKFEGSSDDQMCGSGPGTQPYRAPLVFKDDFSELYVGGRNVLEIVDTSSFSMGRELHFSTCTNPPPENDPCPYVKIIQQMNASCLFVCTTGTLPACYFVDTTDENLSKAPSDFNVDFGEAAPVDSNQNISWMYVTDESKLFTATGRRTGQSESPFRLSNQNGCSNGASDNPIKSDSSEAWLNNAEYVGEPFLHNGYVYFTYREYSSEDINAAGRITYSRIARVCQNDTGGAQFTQLEGEFTTFKKARLDCSLKQADDLRFEYNEIQGTYKSGKTIFAVFTTPRPDVASSAVCVYNVDEIEELFDRGELKGQPGNGLLWAALDDANKSPNFDKLFNCSELFVPLLDPDVTFLQDWALMNLPVPNKRNYMDESTNDYKRDSDAPLFVLDDVRFSQIVVDENVNNMDVMFLGTERGTVIKAYVNDSGAFLVEEVEFNMELPITNMVKGDNSQPFISNGNCMYRYMLPSRSCSNKTACECEEDPYCVCDDGNCIARTNEVGSPGTCNCVPDPPPPPGITKVRPDEPPNNVDSVHRGKPANLNFAARASEGAGLKESEVVCTGEQSAQCGKEESPMETTVTKSVCSGMEYVTVNAVISNVTSECSCNVNFTTNGDEKLATIKIVFDGGDLIVEDPCVQEVTKYDKKIIVYKFELNNWKQQWSAKCLENNSDAAYCNEQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY29</accession>
    <name>A0A914AY29_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069050.1">
        <property type="nucleotide sequence ID" value="XM_038213122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069051.1">
        <property type="nucleotide sequence ID" value="XM_038213123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069052.1">
        <property type="nucleotide sequence ID" value="XM_038213124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY29"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213122.1">
        <property type="protein sequence ID" value="XP_038069050.1"/>
        <property type="gene ID" value="LOC119738285"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213123.1">
        <property type="protein sequence ID" value="XP_038069051.1"/>
        <property type="gene ID" value="LOC119738285"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213124.1">
        <property type="protein sequence ID" value="XP_038069052.1"/>
        <property type="gene ID" value="LOC119738285"/>
    </dbReference>
    <dbReference type="GeneID" id="119738285"/>
    <dbReference type="OMA" id="FPNNKVH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056963">
        <property type="entry name" value="PUS7L_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056961">
        <property type="entry name" value="R3H_PUS7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23943">
        <property type="entry name" value="PUS7L_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25094">
        <property type="entry name" value="R3H_PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="460"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="827" mass="92058" checksum="2DCA03B2402D051C" modified="2023-02-22" version="1">MEQAEYYQHCPRSKLGMDIFLSQHKGFLGSIKTRPGDFRVTEIDLSGKPVQLEKSGDFQGLPSAPCHVKAKEGRSDGDGSKIGGNSSCRIPDGLSVSSKIVGSTSFDDLTELESLTPIFVGIIGVQVMEDLGVFSERELRLNDPSSKTTVRTSDPVHGPVNSQNSLAEDGDTSQEKCFCIGVVQDKEARTFVHKAVQCLFPHLKTSTSKLPDDTSKSVSVSTNPTYWDFRNLLEDLQVGKLIRFAGSKFSTRTFSIDAEGTDSKETRTAIHRLISKHFGKFLETKTCRTASGKQEVVVRFREKFARKDSRGVKRKADATETEGSGDVFTGFTLKKSNLETLDALQKLARVLRVQPSDFSYAGVKDKKAVTLQSVAVKGINSKRLEQLINVANLPGITVGNIHPRIAPIHVGDLTGNLFDILIRDIRHRGDGEPIGENRGVEGALLKEELDTCFASVKEKGFMNYFGEQRFGLLQDGKSQSAAIGQSILSGKYQDAVNQILAPEEDKDDPVNRAKRHFLQTRNAKEALALMPRHKTRECLVLRALHRHGLDRDGCMRALLCIPHAMRQFYAHAFCSLVWNHMASVRLRLYGYRVVAGDLVLMGDEKRGARDKIQEVSEDDVKAGIFSIQDVVLPLPGNNIRYPSNRMGDAYTKYLEGAGLGSCKYRPTELQLNIPGDYRRLIEWPKELRWDLEHIRDDDEIQTNLVPDKLGMDCEVDSKEDRECLGDERATLNFHEVNLKCSNDSSEIDGQNPPESNNDDISLRSELSSSELDEGNSPSDRQATGVNLRVKFRLASSTYATVFLRELMKKYSAVASTMLQQKQDEQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZX0</accession>
    <name>A0A914AZX0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069257.1">
        <property type="nucleotide sequence ID" value="XM_038213329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213329.1">
        <property type="protein sequence ID" value="XP_038069257.1"/>
        <property type="gene ID" value="LOC119738434"/>
    </dbReference>
    <dbReference type="GeneID" id="119738434"/>
    <dbReference type="OrthoDB" id="5797898at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409980" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="241" mass="27872" checksum="0E792EA9C8460F21" modified="2023-02-22" version="1">MSWFLENLIWILFLLLLVSNRGFLQASCPPGWLKWRQSCYIRLPNRMNWFEASEACDRPGGSMIVPNSREENLFIWESLVKGTGGLWIGCTDAAQEGVWLCDGQPAQYTNWHPSYPSRSNKRNCARISAYEGWRWVDKTLCNRQRFAACEMTPFSVPAYHTFTGLDGRVPQRCLLHHDIKNLTAEGLLACGWACWADPRCRSFNLYQSNKKEKMCQLNDVTRLVADDNDFKATDNCYFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B099</accession>
    <name>A0A914B099_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069397.1">
        <property type="nucleotide sequence ID" value="XM_038213469.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213469.1">
        <property type="protein sequence ID" value="XP_038069397.1"/>
        <property type="gene ID" value="LOC119738562"/>
    </dbReference>
    <dbReference type="GeneID" id="119738562"/>
    <dbReference type="OMA" id="GSEANPX"/>
    <dbReference type="OrthoDB" id="10369343at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12832" checksum="EABEA810E57EEE7D" modified="2023-02-22" version="1">MMVWISFFLQQTKARAMPADLILYGGDIITMEGSEANPXSRGADSPPKTEAVAISGDTILAXGSIDDVVFRPAGPDTQVIFLNQQTLMPGFIEPHQHAIQCPIMRSQYINISALNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1R8</accession>
    <name>A0A914B1R8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Thromboxane-A synthase</fullName>
            <ecNumber evidence="8">4.2.1.152</ecNumber>
            <ecNumber evidence="30">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="33">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="34">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 35">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="8"/>
    <dbReference type="EC" id="5.3.99.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_038069744.1">
        <property type="nucleotide sequence ID" value="XM_038213816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1R8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213816.1">
        <property type="protein sequence ID" value="XP_038069744.1"/>
        <property type="gene ID" value="LOC119738847"/>
    </dbReference>
    <dbReference type="GeneID" id="119738847"/>
    <dbReference type="OMA" id="TEMHEEW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="23" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 34 35" id="KW-0349">Heme</keyword>
    <keyword evidence="20 34 35" id="KW-0408">Iron</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="25" id="KW-0456">Lyase</keyword>
    <keyword evidence="22 36" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 34 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0492">Microsome</keyword>
    <keyword evidence="35" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="19 35" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 36" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 36" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="36">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="36">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="34">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="514" mass="58310" checksum="73FE23772A92208B" modified="2023-02-22" version="1">MELFGLDVSVTWTLVVGVLLLLAWYDWWCHHYFQRRGIPVADYIPFFGNILQWRRGIQTTFTDYVKKYGRVVGTYVFRKPVLIIADPDLLKNILVKHFSSFYNRRIPSISQKPLNRGMTRLVNEEWKDARNVITPSFSASKMKKMSSMINECCDTLVASIGKAREGDKFIDFRVVFGGFTMDVIAKCGFGLEVDSQGNKDDPFVKNAMRLLNFNRFNPLFLILTVVPFMGRVFAFLNISLVAPDALKFFTDVTEAACKMRTAEGAQASQRVDLLQLMLNAHNDPEVDQEDTPSSDKAKGKGVVQRKPLSTVDVIGQSLTFFLAGYETTNTLLSFTAYLLATNQDTQEKLHAEIDNLAPTRDNLGYDVIAKMEYMDMVINESLRMYPPAVMFDRACNDTITFEGLTIEKGVGVIASVWTIHHDEEYWNNPEKFDPERFSPENKASIKQCTFLPFGFGPRNCIGMRFALLEAKMALVRVLQQYRFDVCSETEIPPTVGKAGLMSPKNINLKAVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B398</accession>
    <name>A0A914B398_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038070795.1">
        <property type="nucleotide sequence ID" value="XM_038214867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B398"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214867.1">
        <property type="protein sequence ID" value="XP_038070795.1"/>
        <property type="gene ID" value="LOC119739791"/>
    </dbReference>
    <dbReference type="GeneID" id="119739791"/>
    <dbReference type="OMA" id="MVMMEIS"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="220"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="49626" checksum="30F84DA41E944BAD" modified="2023-02-22" version="1">MTVSVHVRPISTDELRHVLAGEAGDTRRVLLVDSRPFMQFNDNHISGAHNIHCPRLLRRRSKGALAMDYIVTCPETRAEFLAGLFSAVVVYDQGTGEIGESTIRDNSDLVLVLESLLQAPVSHLTTEITFLQGGFVKFFRENPSMCSASSDQVQAQARPPMETEEALPAGCGVAPAPSLRLQRLTRCATVPLAMVPPSAGDAASVPPAAARTIPVHQEGEPVQILPHLYLGNAFHAARRDLLEAHAITAVLNVSRCVPNYFLAEGAITYKSIPVDDDNEADLLSWFPEAIDFIDAVKLSGGSVLIHCRAGISRSATVCLAYLMKVQAMRLEEAFEFVRSLRKVISPNFSFMLQLLKYESELKQEREVAGLGGAVLPGRDCHTPHDFSRTLPALFPGARRTRSASLPCLVHGGLSEKPRQQLPQSKCPSVFNFAIAPPCGWQQPDHTQGAKPICSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B581</accession>
    <name>A0A914B581_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071104.1">
        <property type="nucleotide sequence ID" value="XM_038215176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B581"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215176.1">
        <property type="protein sequence ID" value="XP_038071104.1"/>
        <property type="gene ID" value="LOC119739996"/>
    </dbReference>
    <dbReference type="GeneID" id="119739996"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="146" mass="17031" checksum="DAA1DEECD4D988C5" modified="2023-02-22" version="1">MKRNPFVSSSRRKSRKRHFNAPSHIRRKLMSSPLSKDLRTKHNVRSMPIRKDDEVQVSRGHYKGQQVGKVVQVYRKKFVIYIERIQREKANGAQVFVGIHPSKVVIVKLKMDKDRKRLLERKAASRSQRDKGKGKHTEESVAMATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5B1</accession>
    <name>A0A914B5B1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038071268.1">
        <property type="nucleotide sequence ID" value="XM_038215340.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215340.1">
        <property type="protein sequence ID" value="XP_038071268.1"/>
        <property type="gene ID" value="LOC119740136"/>
    </dbReference>
    <dbReference type="GeneID" id="119740136"/>
    <dbReference type="OMA" id="FVERNTH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02903">
        <property type="entry name" value="Macro_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1670"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="2073"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1631"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2268" mass="250617" checksum="B87A5A81BBA133D0" modified="2023-02-22" version="1">MDASRRSIYVGLPRTESIEKKLSVLEDKLTIYFQKSRYGDVDSVLVIKPDRGDKLWMEVTFDEPSGVEQVLSVAQHELKLEGYDLIPLEVRTDLPPKPTESSSDDGEESFVLVPEGNVDKETLKDGGLTKEASAPNKDKNQSPSQTDGPPSRPCSSRIAATLHLPGVASSKTGELPPGPHAAHHTPDPAEMSSQQPTVGTTVQGEEHYVDATDEDLYSPNGSKKPFAEKEVPPGPHSAHHTPDPAEMSSLQSTVGTTVQGEKHYEEGTDEDLYSPNGSKKQFMENQTPYPAKKLKMEASHSQDIANKDLHGRGDDCQKQASSQQQPRASGDRHQRQPVEPSKHQLEGGGATQKGNLRPQQMGAAAQDQMNKQDQDHHGPQNTTKLSGPQKSKKSRRKQKGKKADSEISEQEQTTAGRRGHSEAPLIPQEQVREENSPDEKEEEEEEEEEEEKFVEVTGFNQLSSSSEEMLRMHFENPKRSGGGDIKTWEHDPKAKAIKMTFENPSLTSKVIAKKHKVGGDNLVVRQIVKKKPRPRPVKKRCLFLCGIPDGCNSELVAMFIENRSGTDEFKIQYGEMPGTALCTFKEDIQDFENVIKRISSKVLSGAYLTAEKVKESDCILVKGVSPRTSLEMIELYFDNKKKSGGTGVREVQQGPTDTQAIVYYEDWKVVHDVLSKRSPHKVAGTELLVEEYHECLGRLSQLDAPTPHVPKPVTVQVQKPIMEFIFGKGQHTKKTLTQKLRDAKAILKWPDGDDKTTARLEPLLEDGQRQSSWLKWSETATQILTDSLNRCKSSRIAVPSSFWKDAVDKINQLGTKSFSIQFDASTHLVTLVGEQQDVHKGHTDIDGIIKELRAKTEYEAQQIKEDITLTEEKSQPFIICGIKDKIEKDFPNLKITVISSQDKLRVVFEGSRKIVQEAELSMRRQMDSLEKVELKTGPNKVKFVLNVIDKIHEILGSQGSRAACKGSDDGKIIISGATKKDTTKAKAYIDQEIEEGVIPIKSQAAMDVLQNQTGQRLLDGINKQKFVMAAISSKGNVVELAGFKTNLGETKQKIMLFLKDNVIIKTMVPANKNKICLIENFYGEDLVNIMKNTKNHVKIQPQKGGRRKGFVIQGNEEGSEAASQAISSLIDRIKEQPYPVSKTGMAQLFREDKGKKFLETLEKEYLCVIRENVQEDSDDEAEVEGDAAVRPMVSTRVLCRIALPNGFTLKVCIGDLTRQQVDCIVNAANTELKHVGGLAYDIVKAGGRAIQTESEQILIRSKRRQLYVGEPVHTTGGKLPCKKVIHVAGPKWPHHRGDTFIPDDDEPSYEEHLLYNGVIACLKLANKLNMQSIAIPAISTGVYGFPVDLAAKQILNAVAEFCQSMPNPTLTEIHFTNNDPPTCDVFKKAVMDRFSQFQEDEDGTDVDKGSRGASLGPPIVDDVPQPPPVSAPAPAPRFTSSGQNILTTMEGINITLKKGSITSEMVDVLVNTAGSDMQLGNGAVSKAILQAAGQALQLECSTVTSARGKIPAGEFIQTGPAALTCKKVYHCVCESYSSPARAEQFLKKLVLSLMEDAEQNEMLSIAIPALGTGNLNYPADVTARVMYESVLEFSSQHPNGVLKDIRFVVYDKDVKTIQCFESEIQRLLNPASPGGATGFTPSGHGRKLKKPGSSSGPTDRQAYSAIQRDATGMLQTKIGSVCLQVGQGDLVKETTDGIVNSVGARLDLNGPVSQAILAKGGKNIVQECDFHRNKDPRKLMYVTTAGRLQSSCIFHVVTPRTVEEIKTVVLRSLNEAEKIKLKSVSFPALGTGQAGQSVADCASAIMTAVGEFAVRKKPQYLRLIRLVIFQRDMVSGFQDALQKEVGTSFKEQKGFFSKGLGKFMSALSGAISGATADASTDDESLQETIILNIYAMDMPSVKKAADKIDQFQDEQYTSENLSDEHGMIDKMTDAHGAILKEIERKHHVKIKCCGKGQAKSFNVRGPTLSVKDACIQIQALFTRIQKEELELQQREHLFKEVQWKYSTQHGMEAYDPEVNAIIEEAHKNNRPSVILNLEDGNVTINFQAMEEISPSGNLVVQRIDMKKAASFEMPSNWIPMTKDKHFAMVQLTAGTPEYTTVETQFQSTGGGHTIREIHRIQNRDLLMQYQARKGAMEARLGRTNIEETLFHGTDEQTCDKINKFGFNRSFCGKNATVFGNGTYFAVDSNYSARSQYAKPNANGVQHMYLTKVLVGDYIRGNQGIITPPNKPSHPDQQYDCVVDNVNQPGIYVIFHDAQAYAEYLIKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6J8</accession>
    <name>A0A914B6J8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071435.1">
        <property type="nucleotide sequence ID" value="XM_038215507.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215507.1">
        <property type="protein sequence ID" value="XP_038071435.1"/>
        <property type="gene ID" value="LOC119740251"/>
    </dbReference>
    <dbReference type="GeneID" id="119740251"/>
    <dbReference type="OrthoDB" id="10067432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1407" mass="153298" checksum="AA9C3AE49CC101AA" modified="2023-02-22" version="1">MYNYASAYAAAFSESYKKACDSNPMTAGGGQHYGTCGPYGSATVRGRCPHTARVDGSENPWGGDTRPRSRNAGQLMTGSRWVSPSGYVHRQIDSAKDERNLKPPLQGPQARKACNSDPSAGGSGQRYDNCGPRSATVQGLCPHSARVESGNPRGGDTRPRSRNAGQPMTGSQRVSPSGYVHRQIDSAKDERNLKPPLQGPQARRLSPLRRLPQRNKVRPLNIDGLLLTSEARPPCPSDSARSYAMFNASSQISNTTQRSGNLVVAGQSRKLANITSDRTSSSHPEDDIDRPPSVVVGQAFVPTTSRSKRTWKTRLRSLFAPRSRGTKTTVQPFVTPQGQSEGQVSRPRSLEEDHSDPGQVNRPRSLKEDHSDPGQVSQPRSLKEDHSDPGQVSRPRSLKEDHSDPGQVSQPRSLKEDHSDPGQVSRPRSLKEDHSDPGQVSRPMPLKEDHSDPGQVNRSRSLKEDHSDPGHQSHTSALMKNREAKGFGGDALSIKMHHRQCSAAMATRPASYSNQPLPIPGTPQFDWDRLQSSSHPAPRSDNLITSQKQKEVTSLVANYGDGSLPASTPRNASFRNSSVCNLPSFPSQRQGAKMRDKISSDEEVAIPNADPLTSISRGDGKPHEEGRESGDHGGGWESISIPVSPSPSHQSVSSTSRNSSPSQNVGSETDVEDFIYNVDGESSSVSSMSDSSWAMPNSEADVDVDSFDEETIADKSRQRFTKLPPLRQQRLALKIAPAFALKTSYPEDFAHWLTVVLSCIERRDVMRRMQLASNYKTPFTRKEAWEIHANAAKAKDIMRQLNQIISLSTKDEESSIESLQLASPANPVKKDSEIEGDRRTSNATPQFPKDAWSSREVASSKDSESSASITAKTKFETTLKEHKEKVEKSDSDQEEVTPAECPESSISKLSEMMSTESKPWDVVNKASPCAHLPTISKKSSSNDASRAASHAQKDILSLAEAASENGAEYTSSINAQKYIVYAQTEMEETPRKPQKTEKSDSDRPSGSPVSLLPKLSNKTPTSASLGKVVNKASFEENYHSPQRKISKNSSLKDAATTDNTSSTANASSTNPQVTQSPQEGLPELTAYPSIDPSELEFIMSDNGKEVALGSGSCGGVLLMRHKGDNTLLAVKVLVKNFSFLQHEVAAMHAVRNCLFFPKFVGVIDYCSYAQELVGGVGRNTAYDFRKALHDDLLNALEWLHVCRDVTKGLKALHTAGWLHCDLHCGNAMVCPNPPGSDVAWRGKIIDLGNALQISNPGPVTILDDEQQKKLYELAKQCAPEILEGRDTFTEKSDIYSLGNLFVDVASDANIPHGLRLLGEFCMRRSSDARPTLDAISGKLDDFISEMMQAEQQPSSPSPIPPSSSSPSPNLRCHLIAETVQAQQQPSSPSPIPPSPSSPSPKMRCRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8A9</accession>
    <name>A0A914B8A9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072059.1">
        <property type="nucleotide sequence ID" value="XM_038216131.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072060.1">
        <property type="nucleotide sequence ID" value="XM_038216132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8A9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216131.1">
        <property type="protein sequence ID" value="XP_038072059.1"/>
        <property type="gene ID" value="LOC119740731"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216132.1">
        <property type="protein sequence ID" value="XP_038072060.1"/>
        <property type="gene ID" value="LOC119740731"/>
    </dbReference>
    <dbReference type="GeneID" id="119740731"/>
    <dbReference type="OMA" id="AHTEHET"/>
    <dbReference type="OrthoDB" id="10520569at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="929" mass="101711" checksum="EFBFE73D980ED0E2" modified="2023-02-22" version="1">MQRLMQNSHSSSVDRRARPPMVSNRLEEPMALFAVPLPSSSKSDFLCLCKRLFWSVGTSYFSAFCPLTAEETRLLPHSSAVVQLVSVTPAVPPGNDGKQYLKQDLLAYTIPGDIVGIPYVAISKNHQPRGKLAKAFPFDDLASCAWVPAINAPFVGCTADEIGIGPQKDVFIIKNDEKTRQSLLKGENVIFSQQDGQSSNSEESSIKSAPELRPEQVIPRNLPRKESALPTNVSPTSSSLYKLYNSGKRDTENGTSITPSANGLNVPVKESTPTPPKKKKELPTMVLPRIDAVFSLADSTTTNESLSKKIADTLAKRSAFSSQQSHAVKTSTPVDSGTTSKDAPLKQGDCGIPKSQLTNSPRTSAIGATMASELRESRSGTTRTLATPTMASRSGSVQSSPVCSLDSTRQPDERPSAQTVHPVNAIPRGKTDGGAQAQQQQQLVKLWESSEITPSGPVSQYRQGLENQARSCRRSPGLTVKQILMSRRQLTSPLHFAHSTSVSAGTGAFRSFEAVYANEVADVNDAQTCSAFQTNSDESNTTTLGEAIGIVVDCVNSSDAVSPCEEGEKVKVPPLKMVIKTKRDSDNKVKTTCHPVEEKLADFDGKVLCLKLHKLDISRYSFADSDLIVKSDCESKENASLLGAQETTSVGNTANFQNGDKHVIQPEATVGVHVLDQLTTNLDVEDTVDNIDIGIPGNVKRLASVTNGCDQDGEHKKKKKRRRKFRLTLSKRCKPSHNHDRPTFQRKLERKIDSTLTEGREHLSDCQNTLPKRTKQHILEDLSCNNVSAFDNYFQGQPTDHEPSITHEVAEEFQSHIDGSGKEFATDVSHTAQKIHEFQDDLWSDGASSTDIDSEWECPDKKSAEVDSDWDSSLEDEETNSPFKGVQPIKSSPFGDLQHMVLQDRLRLLEQTLKEHQSVLNAIQRPHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9F7</accession>
    <name>A0A914B9F7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072746.1">
        <property type="nucleotide sequence ID" value="XM_038216818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9F7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216818.1">
        <property type="protein sequence ID" value="XP_038072746.1"/>
        <property type="gene ID" value="LOC119741127"/>
    </dbReference>
    <dbReference type="GeneID" id="119741127"/>
    <dbReference type="OMA" id="GPWENEA"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF46">
        <property type="entry name" value="GAG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="363" mass="40544" checksum="5E87507A221C0955" modified="2023-02-22" version="1">MSDTEFKDALEDFLKAHGKTTEDLPSTPSKPTTSDQPVPKAVGEAVVKHVVSSSSTHRRRLRLFSGKTPVPSGEFDYESWKRPARQLVEDSNISSSEKLSRVIESLLPPASNIVWALGKEATAEECLDGLEKAYGVTADGDELYLRFSECFQRPVEAASEYLVRLQELLTRVQDTGGVNPDRVDNVRIQQFTRGCLYHEPLLMKLDLKKRPTPPNFVSLLQEVRLEEQREREKEERRVGEQKVATKRVAVAAEASPIPMDDVKQLQEAVALLQQQLAAVQTADHHHGIPANPGQQKSSWSRPHPHNRQVQKPRARHPLICFNCGQQGHRLTECANETNAPLVQQQMASRCKPASTSGNEGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA27</accession>
    <name>A0A914BA27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin polyglutamylase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072949.1">
        <property type="nucleotide sequence ID" value="XM_038217021.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072951.1">
        <property type="nucleotide sequence ID" value="XM_038217023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217021.1">
        <property type="protein sequence ID" value="XP_038072949.1"/>
        <property type="gene ID" value="LOC119741269"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217023.1">
        <property type="protein sequence ID" value="XP_038072951.1"/>
        <property type="gene ID" value="LOC119741271"/>
    </dbReference>
    <dbReference type="GeneID" id="119741269"/>
    <dbReference type="GeneID" id="119741271"/>
    <dbReference type="OMA" id="SYRRSCK"/>
    <dbReference type="OrthoDB" id="10249691at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039231">
        <property type="entry name" value="TPGS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36035" checksum="1D9BBC9B68C6455A" modified="2023-02-22" version="1">MPKNSEESGFRLLHFAKSFFQLTIFFPEKRAGICDITLADLQPAERHQVVSWEQRNSCMLPDDLKRFYLTSDGLLLTWSVRFDDQLQSVGRMEINKISNVTKLAGNKAPSNANTPSLADVDYASDEEQCDEDTDVPAKPHFDTRSRIFELDPCRGIAKVCLVYRNTRPGSPAQHPEVWLLDRALRWHFLAHTFSQYFRMMLMHLGLPQWQLAYTDVGLSPQAKQWFNLYSPLRIRLDSETSLAEEEPEKDDSWQAAKGAPKSDSTEVNKLDFGRVFKGKSDKKSKSSQNKKKHGPVGKPLSGGTNNRSGSQLGGGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBV8</accession>
    <name>A0A914BBV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073519.1">
        <property type="nucleotide sequence ID" value="XM_038217591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217591.1">
        <property type="protein sequence ID" value="XP_038073519.1"/>
        <property type="gene ID" value="LOC119741722"/>
    </dbReference>
    <dbReference type="GeneID" id="119741722"/>
    <dbReference type="OMA" id="CRTAEVQ"/>
    <dbReference type="OrthoDB" id="10018381at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100296" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="46574" checksum="1A40BE9CA33A73FF" modified="2023-02-22" version="1">MMFPQASLVDRLAIFIPLVLLWLSSFRAQAQAIAKCWVFSPVVDEASVRAEVSTVSTVEPGTSRQLWSVSSRVTWDRPQTLGSDGAYAVSVLRMPSFQAPQFCTMEENEVLVHTEEHTFTGLDFGFLYEFTVFVLNGTSMAKSLVGVSKGFGTPDCFQATADREFCRGAVVQSAGAPIEPRLESQCQQENSALITARLSWEPPIQLNGHITAYKLQYSEPDAPPGTLPEVVTAMPESTTPEGRVTTDLRNMTLGSSYTVLISAFVIDPEDGSFKEGLQVELKFRITRTTTNVPICPKPVPTTPPPPTAPPMITTPPPKRRPNASAQQPTPAEKPQKPGNGGTHRPGHTPTRPSHEHHQPTTVSTTKGDVKEKPVPTSKKAGIAIAACLVSLGIICAVVMIVLHVVKGKMSKKPRPDTKGAQKGKKTTTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCP6</accession>
    <name>A0A914BCP6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073781.1">
        <property type="nucleotide sequence ID" value="XM_038217853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217853.1">
        <property type="protein sequence ID" value="XP_038073781.1"/>
        <property type="gene ID" value="LOC119741908"/>
    </dbReference>
    <dbReference type="GeneID" id="119741908"/>
    <dbReference type="OMA" id="IACTPLW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="30881" checksum="8813D1BAF1E5F54E" modified="2023-02-22" version="1">MSRDGLLPSVLSRTNERTKTPLLANLLGTCISVVFAVLIDIKILIQTGSMLYTLETVIIIFAVTILRYRPPNRSGGYVELGGVDKGDFKEGANEAHGRKNTTTDLKGLLKPKPETDTAETNATNELPKRPSWIHKGCAIILRWIREHTTRSVILSLCFHLIFEFLLVALLTFKMDDLLRVHDPGLILGIVVSSALTLVSCCPLLLLPQYTDDLPFKVPLMPLLPLIALLAAVILLLHFNSLVYVGVVVWLCLGLIVYFTYGMKHSVEATRQDVHLNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDE5</accession>
    <name>A0A914BDE5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074079.1">
        <property type="nucleotide sequence ID" value="XM_038218151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218151.1">
        <property type="protein sequence ID" value="XP_038074079.1"/>
        <property type="gene ID" value="LOC119742118"/>
    </dbReference>
    <dbReference type="GeneID" id="119742118"/>
    <dbReference type="OMA" id="AYTASPM"/>
    <dbReference type="OrthoDB" id="8186305at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="345" mass="36939" checksum="0FD45DDC008B5EAD" modified="2023-02-22" version="1">MAQQAPDDLDPSRLLKCRRCTKVFLQRRSLYRHIQAAHGPPLIASCLRCSFKSKRRDNLRRHYRRVHPTHLDDLGGILMSLGEDNSEPSPLAPNLHSSGIRRWGAEPPLGQPRMVPPSASPRMRASHGKEQPMAVEPVPCAMATQPSLPLNDLLPINDEALSLSPSPSMSLFIDELDIGAMITAPPEPAYTASPMPAAATAPPVATYTAPPVPAYTASPMPAAATAPPVATYTAPPVPAYTASPVPTAATAPPATLGGKPLALLKSQQVHQPESSDDSDDSTAEDAADTDAPIPVSSKAVATVKKTFLETALEGRVTKVTETLNKYYRSGDLKQVCRVRVYEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BES9</accession>
    <name>A0A914BES9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074380.1">
        <property type="nucleotide sequence ID" value="XM_038218452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BES9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218452.1">
        <property type="protein sequence ID" value="XP_038074380.1"/>
        <property type="gene ID" value="LOC119742505"/>
    </dbReference>
    <dbReference type="GeneID" id="119742505"/>
    <dbReference type="CTD" id="10629"/>
    <dbReference type="OMA" id="QKCRFSP"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000040">
        <property type="entry name" value="TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="7">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="632" mass="69968" checksum="32C28C4AE2674CA3" modified="2023-02-22" version="1">MADDKKFTVLTPSSVKMVGESAGISGLSDEIASMIAEDVCYRLREVTQASTQFMKHAKRKRLNAEDFNKALRWSDVEPIHGYGARDPLNFIPVKDSELFFSEDREINLIDLAMDGKIPSAPGTTSVKASWVAIEGIQKSSGAQAGTGVTHKFQSLSQDFQQYYKDVTKAILESDKQQAELCLSDLRKNTKVSGLLPYLVNFVSCGVKMVSHDLCQLMRLMHLVDALIHNQALFLGPYLVNLISTVKYCILEPLAVSINPLNDHWALRDYAARLLSQILRSSKEIMGRFEHQLLAALKEVLSDPARPLCSHYGAVVGLCALGTRAVEEVLVSQLSSYWPILQQVLEDTSISNSQVKVDGHKVHGAILAAAEMLLKTKQDQSVDEESVTPSQEQSPNASPDHQAEFAFGTASHLMHLSGSGISGSAAADPVRKPKRCSISETYSHLYEYLGDSLTLRLHPKGEPSKQTLEPPKDIDLMQLLNTEHQSSQHYRGNYQGGLLNLTRRKYPNRPRLLSGGTGREGLRPRHAKTPKKIRGRAASLKDAFPLAKTIKIHKSDFKTQLSIPGRLVSLKTKTGTSEESSAVPAWLKTNSDVWKINMRMPVFGKRRIHSTEPSEDIQSSSNQRTVCDLNALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEX5</accession>
    <name>A0A914BEX5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074623.1">
        <property type="nucleotide sequence ID" value="XM_038218695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074624.1">
        <property type="nucleotide sequence ID" value="XM_038218696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218695.1">
        <property type="protein sequence ID" value="XP_038074623.1"/>
        <property type="gene ID" value="LOC119742590"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218696.1">
        <property type="protein sequence ID" value="XP_038074624.1"/>
        <property type="gene ID" value="LOC119742590"/>
    </dbReference>
    <dbReference type="GeneID" id="119742590"/>
    <dbReference type="OMA" id="MMETEVA"/>
    <dbReference type="OrthoDB" id="10453072at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="153" mass="16703" checksum="3B95469EE8C69E64" modified="2023-02-22" version="1">MHGCVIVSHLVLLVILCSKVIQVSLTLNATFDRIMQRKDNFIGKLKMFLAMQFGLPANAMRDFKLRRGSVIVDFKVSSDATSDVNVEDAVDMMETEVSMGRFGFVYEGEEVQAKPDSFQSAPLEEMPGMAAAGPVYSAIGVMAGIVIMIMSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF76</accession>
    <name>A0A914BF76_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074087.1">
        <property type="nucleotide sequence ID" value="XM_038218159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218159.1">
        <property type="protein sequence ID" value="XP_038074087.1"/>
        <property type="gene ID" value="LOC119742128"/>
    </dbReference>
    <dbReference type="GeneID" id="119742128"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="460" mass="50009" checksum="C1FF6EF260110C07" modified="2023-02-22" version="1">MITLCCAPVGKDEDPGPLPEREERRRWLVLLAAYLSFLLWEGLCKSLGIMLQSIAVQLNTETWPVGSAIGIMLAARGLTGPLLRALEVRWQYHQIALVSGLVAGVGVIGASFARTLLQFAACLVLVTGPAFGLVLNISLVLLGQYFHRLYACANGLAYSGASIGILVYAPVSQILLDTYGWQGALLLVGGIQLHLIALGSLQRPPSCHRRGEVGYREVGTDHVLRERHEPSASELNRHISANGRGSCLKFCLKFSKAMGLDLFLDLSYLTLILCMGNLCFVNIAWIVYTVPHLIAKDLTTSSSTTVVWAGGIGILVGQLGHGLLVDFKLLKGRLVMYLANLLMGCTLLCDPLLFGKWPLAASNFFFGLGLGIGLPLTYTLMRDVVGVARMTNAVGWAEMTGGVFRILSSFLTGWLYDKLGSYDLSFVFLGSSSCVVVVILMTEDIYRLIQRRISNRVAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFV8</accession>
    <name>A0A914BFV8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074755.1">
        <property type="nucleotide sequence ID" value="XM_038218827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218827.1">
        <property type="protein sequence ID" value="XP_038074755.1"/>
        <property type="gene ID" value="LOC119742674"/>
    </dbReference>
    <dbReference type="GeneID" id="119742674"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="135" mass="15971" checksum="1A790F88909D0AF8" modified="2023-02-22" version="1">MLIQSEKIKNDYTCLWLARCYIMNRKARLAWELYLKMETSGELFSLLQLIANDGYKMGQFYYAFDVLERLDPNPEYWEGKRGACVGVFQQIIAGHEPRETLRDILQILRNTGNPQMEYIIRVMKKWAKDNRVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH16</accession>
    <name>A0A914BH16_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038075379.1">
        <property type="nucleotide sequence ID" value="XM_038219451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219451.1">
        <property type="protein sequence ID" value="XP_038075379.1"/>
        <property type="gene ID" value="LOC119743098"/>
    </dbReference>
    <dbReference type="GeneID" id="119743098"/>
    <dbReference type="OMA" id="ARIMTNV"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="577"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="780" mass="88653" checksum="6AB1DE3BC84677FC" modified="2023-02-22" version="1">MEDKHTTPYQLALEDSVASKSHSKIPLILLGIFAAATIVLTVTTIVFVLQKNDIAAELDKLKANKPPVLVDLDRAVCTTKQCYDSAYEYLSNMNQSVNPCDNFYEYGCGGWVQRYAARNMTGSYTNILTVLGDELTDKLKVIFERSPVAGEPSSYHIVRNDYQSCVDINTINALGAKPLTDVLTSLGGWPVLGSIPAGGNWNATEFDFEKLWAAIRGTYDVNLIVATSTYPDPNNTAKYKLDAFLPEFVVPSVDIDRTLSQDVRALIDEREDSRSLAVRILLDENYSKERKAYLQYMIDIAVALGANETVAKEDMTKLIEFESHMANLTVLHPDDGIKYVEYTFKQIGMGVINWTRFYQLMLPASVNPGVTDDEPIVNYRPDYIGNVTLWLRDQDDRVKANYMIWRLVSELVPFMSETFLAIEQKYQEVADGTSAATPRWKTCAKNANKIYKYISGRMYVEDHFPEDAKQKTLELVRNLQTAFKSMLKTNDWMQEADKAVAIEKADAMDIAIGYPEWIKDNAKLDAKYADVTAKDDEYLQNNVRYREWTSQGEMALLRQDVNKNESLWATRGPAVVNAFHSPYVNGICFPAGILQPPFYHKDLPWYSNYGGIGVVIGHEITHGFDNRGRRFDKDGNNKVWWSQESIDNFVEKKQCIIDQYSEFVMPQNNRKLNGDRTQAENIADNGGLRESYKAYMDNIPEQPRLPGIDFTEEQMFFLSYAQLWCQALTLKGVDEYVDKWKHSPGRYRTIGPLQNNEAFNAAFNCPAGSYMNPEVKCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHY7</accession>
    <name>A0A914BHY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075042.1">
        <property type="nucleotide sequence ID" value="XM_038219114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219114.1">
        <property type="protein sequence ID" value="XP_038075042.1"/>
        <property type="gene ID" value="LOC119742880"/>
    </dbReference>
    <dbReference type="GeneID" id="119742880"/>
    <dbReference type="OMA" id="CRVWWSE"/>
    <dbReference type="OrthoDB" id="9876908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="43399" checksum="2C39DA3BC331482D" modified="2023-02-22" version="1">MANQPTIYVTDSVTSGQPLLQSFTVSSTATALGGKVDFGLLFSVILSSMGMLGNALVCFVMLRHRKVFYSPTNKLIIHQSFVDLVASTIFFVRRFALAVPPIADGFIGGFYCRVWWSEWPMYGMFVTSTYNLVAISTERYVATCHPIKHRNAFSPFRLKLVMAAAWLAGWLPAAHLTLICYYDAEVRDCGASWPNFEVQAVAGTLIFVHEIIVPITVMFFAYSRIIWSLRRRSRVREGENNDAAREMFSKANRNVTITLVVVAAFFAICWLPTDIYYLLYNLHVHNNFVEHPVYQVFSVIVVLNLCINPLIYCFAYDRFRKKLKQEFCGNRWLARRVGIAEDGTSNDTGTRITVAAGRGATAGNDKTLTTTVQTAGCSFQTETVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKB6</accession>
    <name>A0A914BKB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IQCH-like ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076728.1">
        <property type="nucleotide sequence ID" value="XM_038220800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220800.1">
        <property type="protein sequence ID" value="XP_038076728.1"/>
        <property type="gene ID" value="LOC119744723"/>
    </dbReference>
    <dbReference type="GeneID" id="119744723"/>
    <dbReference type="CTD" id="64799"/>
    <dbReference type="OMA" id="MHEFIIR"/>
    <dbReference type="OrthoDB" id="2117703at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056855">
        <property type="entry name" value="ATP-grasp_IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465:SF0">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24923">
        <property type="entry name" value="ATP-grasp_IQCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQCH-like ATP-grasp" evidence="2">
        <location>
            <begin position="691"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123938" checksum="5AB8CAA36FFFE30B" modified="2023-02-22" version="1">MTEVERRPEEVGEILVKVQEDLHHLKEHLMQKSLSDGHRELIDLTALQNAIQKTEDGIKAQSEKIIQVVNNRVTTLPSVDASSKAKTMEPSSFSQESVFDLSGLGSDLPLRRISNKGLADKKLVSRYTAVDPLGGGGGPCGPSPGQQAKLLYNLKAIQDPTSTLNRKVVSDNYGVSLPLIVDKRHKVPTQKVVMGSNVEHLAVLPKANRVDPQLIPPPISEKDARKGILSLMERGLIPPAAELTLDPSPVRQKLQTLHDAQDKKNIPKGPPLGFGDGSFNLASVKLDLDPYPMEPMPTRPIVARRPRSASLAESPEPAWVSPRSGATSAKSARSLVPVKNMEPLPPPTTPASEFKHLHHRFAIQHGRLRESSKDFAAFKQHYCLSWGNIVTMLRHLEKLLGNYAVPLAFINGDKLADLAVEFELDKPPTTKALLGVIMNIDDVMALLNRPGRRFLGPDGEDVAATKIQSTWRRYKDRSQYLEYRRKKWAAGVIAISWVMHVKMAMVRKQLKETRKIQLEEFRRRTKDFSASWDRIQRNRRVIVHIPSLGYSQKIRTTIGDFNIQQNQQMARLCDLHDPNVEVIYVSPVNINDETLQYYNKLLGLRPAVESGNVEDQRDMSDRFKIIVPEAINSFPTHSMCLSTLLKYSPRALQRIQNLTAGKEAYIVPGVMHKDDLSLAHELNLPILGCEPEVSHLYSTKSGSKRIFASAEVDVPPSDFDVYSLEQLHESLAQLVTDNLDVKRYLFKLDDEFDGRGIAYCDITPHLRCHSWAKKEAARYGEKWAKKWAQEPAYIKIRAEVPDILANNATPINKKLYSSWPKFLEAFLSQGGVIEACPPSDSVTAITVNILITPDGKVTLVSSGDQIHAHSPFTCWGLSVPQSSVDPGQLNRACAKVAKSCLQRSVMGYFAVDFVTFIDPNTRDQKLWAVDLNLWYDDTVSTTGLMLYVSGGTLNNKTCEFHVPPPKKERKKSIRRRYEDLEPEEPPNTSRYAVMSTRLLHTNLAVVHYSVFFQMCRAHGIGFDIKEKQGTAFTLIDSYKREGIGMLTVGEELQGTLASFARNLSVIHQEISAPNMQGQSNFQAAIEDIEGILGTTIQNMDRPEDEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKH4</accession>
    <name>A0A914BKH4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076609.1">
        <property type="nucleotide sequence ID" value="XM_038220681.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220681.1">
        <property type="protein sequence ID" value="XP_038076609.1"/>
        <property type="gene ID" value="LOC119744636"/>
    </dbReference>
    <dbReference type="GeneID" id="119744636"/>
    <dbReference type="OMA" id="HHIDGSC"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037757718" evidence="6">
        <location>
            <begin position="19"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="8">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="583"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="664"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="749"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="792"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="878"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1609"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1695"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1333"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1634"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1720"/>
            <end position="1729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1879" mass="202117" checksum="4BC79B2235F4D237" modified="2023-02-22" version="1">MDLCWLLVTLAVCGLCQAQDCPDVDEKALPPRQTVGVCEYEKPIIVTVNRQVKAVRQEPYNVPCGIQNTDSCVMHRSVYYLKTTPVEEPSTETVLECCQGYTGDPGTGCTPTCTIPCANGGTCTTPEECSCPAGWTGVDCNTPCPTNTFGVQCSQRCTCENNGRCNRFTGECQCPPGYQGFHCEDECADGTYGLRCQFLCECHNLAACDVVTGTCSCASGFQGQLCEEYCDQGSYGPQCSRTCRCQPGAYCYAEDGSCSCPPGYTGDFCENECSQGFYGVNCQSPCMCENNAACDHVDGRCTCPPGYTGLTCRSICSPDMFGQDCRQRCTCQNGACHHVTGVCSCFDGWTGANCDAPCRANYYGRNCFEECQCLNGASCHHMTGVCQCTAGWVGTFCRDPCPQGRFGMDCTSPCRCDNEAACHHVDGSCRCRPGWKGAVCNEPCAMGFYGLECAERCQCRNGAECNHISGACRCTAGWQGRNCERPCSEGFYGLGCNRACRCRNGADCSHIDGECSCTPGWQGQYCDAPCNPGRFGYECRMDCLCQNNAACHHVSGLCTCSPGFTGSTCSDICPMGYFGQDCRSECQCQNGGACHHVTGVCSCTAGWLGLTCSDPCPQGKYGLDCGDNCMCKNDALCSNIDGSCSCAPGWQGTICDQPCGALRYGTRCEKICRCQNGAICNHIDGMCTCTPGWQGVFCDVPCDDGFYGHNCAKVCRCVNGGICDTVTGACTCPPGWRLFCSDPCESGFFGQDCSGVCRCQNGAECSRFDGTCTCTAGWYGASCDSPCRPGLYGPGCEQNCRCRNEATCSRFDGSCSCAPGWTGRFCDTPCREGFYGADCTEECTCVNSLSCSPFDGTCSCSAGWKGQNCQDPCDNGWYGPGCSSPCQCRNGASCSRIDGECFCTTGWQGRYCEDECDRGTFGPGCTETCQCQNNAPCSRFDGTCECSPGWMGLQCNIACPRGFYGANCDRECGCSNEASCDRVTGECVCTAGWTGRFCDTACSRGLYGPNCESNCLCENDASCNRFDGTCQCSAGWTGRFCNLACERGRWGVACSEACQCQNNAACSRFDGSCSCSAGWMGRACDIPCRHGTYGINCQGTCSCMNEAFCSRFNGACLCPPGFMGSSCEQPCPEDFYGLQCKLPCTCANRVSCSPVDGSCICQAGWMGDLCDTECPHSRWGVDCSQFCSCSNNAGCNRFTGECACGSGWTGKDCNIECSVGFYGVNCLQRCSCANNAPCSRFDGSCSCGQGWTGPNCNEPCEAGFFGENCQHACGCQNSGSCNRFDGSCICPSGWEGTFCNQPCMEGFYGRNCENRCECQNGASCSRFDGSCECDAGWTGFECDQPCGDGRWGPGCMQRCYCRNDATCSRFDGVCSCTTGWMGRYCHLPCTQGRHGPGCTALCQCRNGALCDRFTGRCMCTSGWKGVLCDIECDEGTYGTNCAQTCRCENGARCHRETGACSCSPGWQGEFCNEPCVGDRFGLDCQDQCDCRNGGLCDAITGACNCPAGWYGLTCEQRCPPMRYGPGCSQICRCLNEATCDPSTGRCECLSGWMGTRCDVPCQQGRFGIDCLQQCDCENDAQCSRFDGTCVCPPGFVGQRCERRCSGNTFGLECTAECQCQNGGICSTFDGSCICQSGWMGQLCQIPCDAGFYGPYCNSPCRCFNGATCSRFDGSCACTDGWTGSSCNIACSGGRYGQACAQRCQCQNGATCHHVTGACTCTQGWTGPFCTQRVQEEVIGIGKRQTVAGRVVTCNQASIFPLNGYHYFECLDIRVDNNLRFPNTITCRNLWVDRIIDSTSPGYTERTDHLDFCIHLLKANKLDGRFEDRDVSIEARYTCSRTRETRIQWLYSSWRYGGSQDAGYTQDLRCKVPLGKLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLC4</accession>
    <name>A0A914BLC4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077093.1">
        <property type="nucleotide sequence ID" value="XM_038221165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221165.1">
        <property type="protein sequence ID" value="XP_038077093.1"/>
        <property type="gene ID" value="LOC119744941"/>
    </dbReference>
    <dbReference type="GeneID" id="119744941"/>
    <dbReference type="OMA" id="EKTPQCI"/>
    <dbReference type="OrthoDB" id="8185227at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054709">
        <property type="entry name" value="CFAP107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037662">
        <property type="entry name" value="CFAP68/107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180:SF2">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22595">
        <property type="entry name" value="CFAP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="238" mass="27729" checksum="597B0CA3E4933F1A" modified="2023-02-22" version="1">MAQGDPMKWNLPGWRIEQKYSPGVLIGNWSENRNKFQRAPIKSGSTHRTDFVKYPQYRPDVMTRRNAMMKNDGLDNKHLFAHHNNDFSSNLISWYDEQFNKRERMGRDTLPELRYWDSNRLAWEPEKSDHPIRDGPSTNFGLQEKLNDKWKREQALAGLGEYHTTYGQSYIPQPSNALVRNHYAPPRELSTRLHPVNLINKDLGLRSVNVLQTPQELQLPTRTEPATRSLHGPTQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLL4</accession>
    <name>A0A914BLL4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077183.1">
        <property type="nucleotide sequence ID" value="XM_038221255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLL4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221255.1">
        <property type="protein sequence ID" value="XP_038077183.1"/>
        <property type="gene ID" value="LOC119745032"/>
    </dbReference>
    <dbReference type="GeneID" id="119745032"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="369" mass="41683" checksum="0B57F1D87B37CBE7" modified="2023-02-22" version="1">MSVHPAYKVLLLLISVVLVSLIIFNSIPYTVVLKPLAVYHVGKWSAVGKECGATHANTGINTVSYGNENISREIHDEQEATDRTEIPVQGRVTAKIAITERVTRGRLSNCSLADIRKRSGVVLLTTTNFAFLDMTLNMIESIKRAGLCVNTTVIAEDQKCHQYLKERVRDDPAVHVIMTSSGETKSQLIRRYTREFFRFFNKRQAYILALLEQGLDVLFTDSDTFWFRDPFPYFRGDFDMSMMDSKSPYPTRAENANFCAGFAYYKSTAVTIRFVKAWIQTMENNEKAGKIRADQGVMNSLLRSDDPVHVHVQPLDINLFPSGPKFYSLLAKQANYSAIVMHAASIRGHEAKIEKFKSSNMWLVNITTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMA7</accession>
    <name>A0A914BMA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077418.1">
        <property type="nucleotide sequence ID" value="XM_038221490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221490.1">
        <property type="protein sequence ID" value="XP_038077418.1"/>
        <property type="gene ID" value="LOC119745256"/>
    </dbReference>
    <dbReference type="GeneID" id="119745256"/>
    <dbReference type="CTD" id="9325"/>
    <dbReference type="OMA" id="EFNSYRH"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056994">
        <property type="entry name" value="TRI4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23135">
        <property type="entry name" value="TRI4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="448"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="594" mass="66671" checksum="EB8353817FA5F66E" modified="2023-02-22" version="1">MATSIGPLIQWCSSELSALLGGDASEDFAKYLLEIDNVKDLEDYLQELLDIADPKAQAFIQELLRKKHCSAPPDNMTVYKKPVEDNDYAPKTTKTQAKSKVKEKKPGGFIKVDLSALKSEIRMPGDPPPPATVPPTAAPHQPIAEAQANRQGAKRKQKYVALYSKEGEARSVVHLAGRHWCECQAQKHSLVANCLKCGRVVCHQEGSGPCLFCGTLVCTREEQEILARNSKTSEKLRRKLMGEGKKEEPGAKVANNGDISLPHVAARLQSGLDKALQHKDRLIEYDKTSVRRTKVIDDESDYFSTDSNQWLTKDDRAKLEKRKQELRELKHGSRLKKTFTLDFAGRKVVEDTDQVNMYDGQDEVVQAVNFGKSGQVKGHRGPVGDSDIINPNITQDAPHFVQSKEDRYRLSDPATMHKSEKLSLSSKTGALRIQDRELMEMSDEGYCLSMHQPWASLLVTGVKKHEGRTWYSSHRGRLWIAAASHQATAEEIAQVENAHLATHQADDAEEEIFFPREYPTSCLLGCVDMVDCLSQDQYQEQYPRGDSSSPYVFICENPQELVVRFPIKGKHKIWKMDGQILKAAKKGLRKPKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMQ6</accession>
    <name>A0A914BMQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076752.1">
        <property type="nucleotide sequence ID" value="XM_038220824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220824.1">
        <property type="protein sequence ID" value="XP_038076752.1"/>
        <property type="gene ID" value="LOC119744737"/>
    </dbReference>
    <dbReference type="GeneID" id="119744737"/>
    <dbReference type="OMA" id="SYFGREN"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="46411" checksum="7D4CBDC40891740F" modified="2023-02-22" version="1">MGQKISCRLTGKAGGWAGPVAVLTMWTYCFMSTGVIKALGVMLPTLRDQFETKSWVIGWITSMVVAMSGFIGPFVGPLVRRFGASGVIMTCGAMLGLASIAGSFAIATYQLALAYTLLAGAGLGMSDVISKQVVGRCFDQNHATAIGIARTGASMGLFISAPVVQILLDAYGWRGTMLLMGAICSHMILCGALMHQYGSSKPRNEDYQEIQGVSDFSSAIHPANLLSSLCTIWKSFVVNLDLKLFLDIRFWLTAIIYCNSKFAIDMWKIYFVSSVVSRGFSLEDAAAFVAVGGVGSLVSKLAQGFIVDRGILPCWAVMAIGLGCGTVSFCTTPWLKSYWSIMLLSSLLLMTGYGLTICIDVAVKQMLGVDLLAGVYGWIGILTTILRCTLGFLPGLMYDYSGSYNAPFFFLGCMCMPSLFSVLVLRYKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMZ4</accession>
    <name>A0A914BMZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="11">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038077315.1">
        <property type="nucleotide sequence ID" value="XM_038221387.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221387.1">
        <property type="protein sequence ID" value="XP_038077315.1"/>
        <property type="gene ID" value="LOC119745163"/>
    </dbReference>
    <dbReference type="GeneID" id="119745163"/>
    <dbReference type="CTD" id="54617"/>
    <dbReference type="OMA" id="FWKKNER"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001304">
        <property type="entry name" value="DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="15">
        <location>
            <begin position="289"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="533"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1019"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1430"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1449"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1570" mass="179127" checksum="621C6F0E79C4DE00" modified="2023-02-22" version="1">MSEGSKAVGSDAVLPEGPVGGVPQAKPLHIQRLEKAICLEPYLAYVEKVLTASTPEHSQEELYKEEIGRDAVPPDDEALKEDDNRDKDIKTVHGLITSRAERKADRRRLYNLCKVKKSRRWLKNILLSDSSDSSAAEEEEEDKPLTAEELKEMIQLHRYKRQCQSKFYTEGELQQYQYYSTGLLSSYDNFLDHKKLVLGPKEKQLKKEKVSPSQSVPIMPEEQPEPEKLKKVTPKPKKKVETKEKQDVQVRATPPALVSVATSVAHFQDALNHKKLMAIKDVEARRRRVWHAIIRKDIPKAQKHRTSVHNNILTNARKLAQACQKEQRRQAIASQRVCKETPHRARRMTREMTAYWRHYDKVQKEHRKKAEKEAQEQRRLDDEMREARRQQRKLNFLITQTELYAHFMSRKLTGEGEEQKEQILSRLEDHTPRRQLTIQGGVLVDVEEDDYDCDFMKQQALSNVSLAYTTHQERQQVFDGDDPKPETTPSQQAFDKEFSLSNPAMLSESERPQPSMFRGQLKSYQLRGMNWLANLYDCSINGILADEMGLGKTVQSIGFLAHLAESQGIWGPFLIVAPASTLHNWQQECARFVPNFKVLPYWGNPQERRILRKFWSQRPLQTTDSEFHILITSYQLVIQDIKYFQRIKWHYMILDEAQAIKSSSSVRWKLLLQFSCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAERQSGINEEQLSRLHMILKPFMLRRVKKDVENELSDKIEILVYCHLTTRQRLFYQALRNKISIEDLLQSSSSSSSSTSSSTSSQSLSTANSLMNLVMQFRKVCNHPELFERRDSYSPFYCQLDPPVHILPRLIYHEGMVDCMDTTRNKLLRSTFSVFTPDYIHTSLAPSPSHRPRSSCFSFARFVDVSPAQLHSQLVMGLMARWLALFLIMKSAYRVHHGYQWATDKDHSRYLSRRSLLLWPCWPTSPPNVATSQPFQDLIFTGHTSTLVSHDTHTYYFMPETHWHRRIRLGGVQDSDSASVNGEGTPDRQSPRSPRSSGGSPRSPRSPRSPAAARKVRQGNSSHNVSGLLSSGHFLPIMSDRPSAVRICSPTLLPDFISHYMPKVLAPSMGRYCRDRQAEYDRIRQELGGSLDAWQCALHGSPDHYRDSLKGALFPPPLAGMRAVRPPHGWSKIHIPDKQYLVTDSGKLYVLDELLTRLKRQGHRVLIYSQMTRMIDLLEEFMWHRKHTYMRLDGSSKISDRRDMVADFQSRSDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEEKILQRAREKSEIQRMVITGGQFKPEQLKPKEVVSLLLDDEEIERKFHEQQREKKLTEERNRAKDRKRKREKYAEMKKEAVKKIKSDTLPGIPLGSLAPDSANVSVDGEDSILSMDSGAPSPLSVVSVGSETQHQSQTYTPVSIDENSNDGLVIADEQSQLGDGELDDSARPHLPGSGKRGGASQGGKTTPSPGTKKLQIRPGRARKGTGAAAIAGARAGAVAGTAAAYAAYGFSFKGKGRRSSILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN12</accession>
    <name>A0A914BN12_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077335.1">
        <property type="nucleotide sequence ID" value="XM_038221407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN12"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221407.1">
        <property type="protein sequence ID" value="XP_038077335.1"/>
        <property type="gene ID" value="LOC119745183"/>
    </dbReference>
    <dbReference type="GeneID" id="119745183"/>
    <dbReference type="OMA" id="ALLMNHF"/>
    <dbReference type="OrthoDB" id="2019266at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23745" checksum="65A3358F9810ED08" modified="2023-02-22" version="1">MTEIIKHNYVLSSCTFFKPHVTSFSQDVKSSGYEAPRVCAEALGKVLSDKSALIVDCAAGTGIVGEELLYLKNIGFNSIDAVDYSQQSLDISASKGVYRRLICNKFDENKIEEIKDDSCSALICVGALLMNHFTQTAFPEWNRIVKQGGFMVFTLSRVEYDDGLPDHRLVIGNGIQELLDKGTWELIEKTAIPYHSGYLADMFTIRLKNKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN69</accession>
    <name>A0A914BN69_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064667.1">
        <property type="nucleotide sequence ID" value="XM_038208739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077395.1">
        <property type="nucleotide sequence ID" value="XM_038221467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN69"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208739.1">
        <property type="protein sequence ID" value="XP_038064667.1"/>
        <property type="gene ID" value="LOC119735048"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221467.1">
        <property type="protein sequence ID" value="XP_038077395.1"/>
        <property type="gene ID" value="LOC119745243"/>
    </dbReference>
    <dbReference type="GeneID" id="119735048"/>
    <dbReference type="GeneID" id="119745243"/>
    <dbReference type="OMA" id="FYFDTQF"/>
    <dbReference type="OrthoDB" id="10051210at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="38918" checksum="E8EA5C8E18E98311" modified="2023-02-22" version="1">MSDIEGMFSQVLVPRDDRDLLRLLWWDNGDIKRPLTEYRMTVHVFGAVSSPSCANYALKKTADDHAGCEEIAHIIHRNCYVVDCLCSTPTVSKAGQLVKGLTETCSKGGFHLTKWVSNKKEVLENIPKDERGRNWKDLNIDGEKLPVERTLGMMWSIEDDEFGYKIEMRDRPPTRRGILSTVSSVFDPLKCVSPVVPPAKQLLQAACRMKLGWDEEIPPDLSKKWQNWQLELPRLAEFKMVRCLKPDGFEEPKSVTLHHFADASELGYGTISFLRLVNYEGEVKCSFLMSKSRVAPLKQVTIPRMELTAATVAVRVDHMIRKELEIEVDDTYWTDSMSVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNZ3</accession>
    <name>A0A914BNZ3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038077854.1">
        <property type="nucleotide sequence ID" value="XM_038221926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221926.1">
        <property type="protein sequence ID" value="XP_038077854.1"/>
        <property type="gene ID" value="LOC119745532"/>
    </dbReference>
    <dbReference type="GeneID" id="119745532"/>
    <dbReference type="OMA" id="WLEFINE"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="98"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="573"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="777" mass="87890" checksum="7DB120FA6199C332" modified="2023-02-22" version="1">MKDKLTTSKAQLAREDSVVSKSPSKIPFILVGIFAAVTIALMITTIVFAVQKNDIAAKLDELKANKPPVPVDRETCTTKQCYDSAYAYLSNMNQSVNPCDNFFEYACGGWNQRHTVPEDQIKVSVFSSLRDDLKDKLKVLFERSPIAGEPSSYHIIRNDYQSCEDLDTINELGAKPLTDVLTSLGGWPVLGSTPAGGNWNATTFDFEKLWAALRGTHGVQIIVYIDTVTDPNNKTKHKLTASTPFFVVPKVGIEKTQLRGVKTLIDERDYSEELGIKILLDESYSKERKAYLQYMIDIAVALGADETVAKEDMKNLIEFESNMANITVLHPYSGTTENTLKEIGMDVIDWTRFFQLMLPASVDPGVTDDEPIFNYSPNYIGNVTMWIKDQDNRVKANYMIWCLVSEMVPFLNETFLAIQHEYQLEVNKTMSPTARWKTCVNNANDQYMFISGRMYVDEHFTEDTIQKTLEIVHNVRTAFKSMLKTNDWLQEEDKGVVAEKADAMDIAIGYPEWIKNNTKLDAKYADLTATDDEYFQNNLRYREWLSQGALARLREEVKDDYSLWSFGGPAVVNAMYGAAINGILIPAALLQPPFYHKDLPWYSNYGGIGVIIGHEITHGFDNSGRRFDKDGNYTVWWRQESIDNFLERAQCIIDQYSEFIMPETNRSLNGGQTQGENIADNGGLRESYKANMGNIPKQPRLPGIDFTEEQMFFLSYSQLWCSVFTPEGADDVIDNDVHSPGPYRVIGALQNNEAFSAAFNCPAGSYMNPDLKCKVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQF6</accession>
    <name>A0A914BQF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077896.1">
        <property type="nucleotide sequence ID" value="XM_038221968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221968.1">
        <property type="protein sequence ID" value="XP_038077896.1"/>
        <property type="gene ID" value="LOC119745556"/>
    </dbReference>
    <dbReference type="GeneID" id="119745556"/>
    <dbReference type="OMA" id="KRQVGYR"/>
    <dbReference type="OrthoDB" id="10043580at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="159" mass="17854" checksum="17AD4C47E9DC06C2" modified="2023-02-22" version="1">MAGRPSGINYVKPSEPSFLTKFKQHAGYKEGPSVETKREIPKFDDDDDERPEADDDKPTVVVLRDGDLTQTEAEEFMKDVDKKDEETQPSDGKILFKKPVKRSSEEGTGSDLNASSSKKKKEHKDKRKGSGDRKDDRKKVKNASLLSFGDDDDEEEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BST1</accession>
    <name>A0A914BST1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079030.1">
        <property type="nucleotide sequence ID" value="XM_038223102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BST1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223102.1">
        <property type="protein sequence ID" value="XP_038079030.1"/>
        <property type="gene ID" value="LOC119746265"/>
    </dbReference>
    <dbReference type="GeneID" id="119746265"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037317764" evidence="1">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="126" mass="14901" checksum="479A96771B7C9FB4" modified="2023-02-22" version="1">MERRLFLGWPAILVLLVPLLFELPRQSSGAPFNYAAHCRDMDSGTNSLFIYTVREYQDRVADTYSRHYGTELTPPHGVNRLVRMFYRLREVRDEAQDIDQLVSEVEDTFLLRLERLERDCKRQIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSZ6</accession>
    <name>A0A914BSZ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078726.1">
        <property type="nucleotide sequence ID" value="XM_038222798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222798.1">
        <property type="protein sequence ID" value="XP_038078726.1"/>
        <property type="gene ID" value="LOC119746040"/>
    </dbReference>
    <dbReference type="GeneID" id="119746040"/>
    <dbReference type="OMA" id="WESAYED"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="204" mass="23022" checksum="63F2C97AEA7196E7" modified="2023-02-22" version="1">MAASTASCSLQCLHTRRDLLRSCEELLKSIWPHSATERLYRLESEECIGLPCSLVLIEHRAGSPDEVIGHVRLVKVSHPETPKSAFIEGVCVKRSFQGSGLGKKLMQLTEQYMAEELGYEQAFLICLAPVGDFYRRLSYEEFPILTLETVGANLLLTFDRVSWYGNKPAIGWESAYEDGPIVSEDEMRLQAYGQLTMRKYLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTL1</accession>
    <name>A0A914BTL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centromere/kinetochore protein zw10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079385.1">
        <property type="nucleotide sequence ID" value="XM_038223457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223457.1">
        <property type="protein sequence ID" value="XP_038079385.1"/>
        <property type="gene ID" value="LOC119746487"/>
    </dbReference>
    <dbReference type="GeneID" id="119746487"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009361">
        <property type="entry name" value="Zw10_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06248">
        <property type="entry name" value="Zw10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="95" mass="10828" checksum="E1D851EC192FB8F1" modified="2023-02-22" version="1">MTSLVTDVLLANTDLLEKEDLGTRIGKLSTHIDEIKGEIYHAVHEKYANYRPTRDSTQELHNKVQTLSTEMQTLSNKIKVLTHKITIPPAPLTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZB6</accession>
    <name>A0A913YZB6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038044076.1">
        <property type="nucleotide sequence ID" value="XM_038188148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188148.1">
        <property type="protein sequence ID" value="XP_038044076.1"/>
        <property type="gene ID" value="LOC119718746"/>
    </dbReference>
    <dbReference type="GeneID" id="119718746"/>
    <dbReference type="CTD" id="10380"/>
    <dbReference type="OMA" id="QTEADRC"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000023">
        <property type="entry name" value="Protein CBR-TAG-231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="34594" checksum="222AA07DCF2F5B44" modified="2023-02-22" version="1">MAASSASPLIVRLVSASVAIANRAGSIIRKIMKDGSLNIVQKGGEGIFDPQTEADRRAQHCIVASLMTRFPGITVIGEEELEKEKMEDRQVEMGDSQEVLAVECPPQYQDVDLKDVVVWVDPVDGTTEYTQGFLDHVTVLIGVAVKGIAVAGVIHQPYFNYKTSPVEEQGRTMWGILGLGGFGFEHKESTKRVITTTRSHLTEDVQKTIDAMKPDEILRVGGAGHKVIQLLDGTASAYIFASRGCKKWDTCAPEAILHAVGGRLTDCHNKSYIYHKDVEHQNTGGVIAAYSNHQFYVERVPMSIREKLPTQTGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0A0</accession>
    <name>A0A913Z0A0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">WD repeat-containing and planar cell polarity effector protein fritz homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat fritz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044090.1">
        <property type="nucleotide sequence ID" value="XM_038188162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0A0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188162.1">
        <property type="protein sequence ID" value="XP_038044090.1"/>
        <property type="gene ID" value="LOC119718755"/>
    </dbReference>
    <dbReference type="GeneID" id="119718755"/>
    <dbReference type="CTD" id="51057"/>
    <dbReference type="OMA" id="NSMNWNT"/>
    <dbReference type="OrthoDB" id="10013020at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097541">
        <property type="term" value="C:axonemal basal plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024511">
        <property type="entry name" value="Frtz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667">
        <property type="entry name" value="HOMOLOC-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11768">
        <property type="entry name" value="Frtz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="721"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="86271" checksum="B00955762EB6A06B" modified="2023-02-22" version="1">MASCMVELHIWSLKSSVTIRDIDVGCHTYHDKGETVVTGYLDQKQQYAESRDLLWTPKNRRPEKLRDLLKEVEDLLTSHQVVFTRWRSRRQFQVMLSNCVLLSFQVSAHSGDVERILIDKTLQGKFCSENINSAVVTDSFVVCTFPDKPKLGYAYFSKRPSSGQETGKKMDKMSSYDPKITHVDLPGVKTKRERKLSVNVSQEWVLVWCCTGRDDSSAWPWTPMTSDKERANVFLYAVNGSKLEELCFVSTEYEPLDVTFSHSQPRHIYTLEGVSSSTSGDYNVDTCIYECSKQGYIQRATVTTIPLKARVVAHGRNHSEDKLILGCSDGKLVLYDESKRVTQFVQSDLVSSLITWHPAGSLVLVSGNKGEIQCFDMALNPLNLLTVGETSRSLPTLQLTKCFRSPVTIGTLVWSHSTSLSDCIADAQDSLLMIFNGGPISILQLHLGVLSRGQLGPQELIQQYLNHQQINEAVNLLNVMNWNTDSGSCFTCLTTIINNLLKLPLNPDREAALEASLGSFYAPLRPLSEVIVVDYRDPISRLARRFFHYLLRYQRFEKAFLLAVDLHSRDLFMDIHYLALDKGEMALATVAKQKADEIEQEMPSESDNFDSLSDSVEEEDFSSDSYSSGSEDQPRPASPARATGASGRDEKQRGPGSSRASPEPVRAGRHIEREAWYQAEEQIDVAYGLGSDLEEIHLDASEGLASIPGDVYTQVLTDNPFGWDNQKPDDDQRSREAPEARGGIVEEGEGQERKEDGTTKTVKVIHFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1I6</accession>
    <name>A0A913Z1I6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044545.1">
        <property type="nucleotide sequence ID" value="XM_038188617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188617.1">
        <property type="protein sequence ID" value="XP_038044545.1"/>
        <property type="gene ID" value="LOC119719242"/>
    </dbReference>
    <dbReference type="GeneID" id="119719242"/>
    <dbReference type="OMA" id="IATNWID"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="36819" checksum="139334353E66C97D" modified="2023-02-22" version="1">MAPAENAMEVVVPVTPMEEEFNVTDTDEASAYLPYGVTNTVFICVYGVNFILIMTINPVCLLVIRRMANMQPTTKNFMTSLLVSKMGYGIFVLIPFMIRTNVVFAEGSFWWILFFICDVVFNWQSFLSLLLLTVDRYLAVAWCLHYPRLMTIRRSRIIICISWAAGLIFGLAFFFSTGTSLHAYTIQNFILITIIFIGIALIVTLYLHILVIARRQARRIAQDNQAVAGNNAPQRVSTKSFTTIFIIVTVILLCWIPVCLFTLLLRVQVYVSPVVYFSFGVLYIATNWIDAVLFCARNKEFQKTLPKLALACFNGLMQKWNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2K6</accession>
    <name>A0A913Z2K6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="21">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="21">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038045231.1">
        <property type="nucleotide sequence ID" value="XM_038189303.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189303.1">
        <property type="protein sequence ID" value="XP_038045231.1"/>
        <property type="gene ID" value="LOC119719806"/>
    </dbReference>
    <dbReference type="GeneID" id="119719806"/>
    <dbReference type="OMA" id="RCWQECE"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 21" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 21" id="KW-0408">Iron</keyword>
    <keyword evidence="13 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 21" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="253"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="1288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="281"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="907"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="939"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1106"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1356" mass="148806" checksum="D2581172F3B3525E" modified="2023-02-22" version="1">MVRVLSTLTSLTTDTIMDNLAVKSDSDTLLFYCNGTKIFDPDVDPALTLLTYLRTKLRLTGSKLGCGEGGCGACTVMVSKYSPKDKTISHIAVNACLTPICSVHAMAVTTVEGIGSTTTRLHPVQERLAKAHGSQCGFCTPGIVMSMYTLLRNRPQPTMEEIESTFEGNLCRCTGYRPILQGYKTFTKDGCCGGTNTTCCKNIPNGISVQEEGVLTTLFDASKFTPFDPSQEPIFPPELMINLYEMDSRPRTFVGVRVAWFRPVTLQQLLELKATNPKAKIVAGNSEVGVEVKFKNQHYPVLVDPTHIPELTSVERTPSGVRIGAAVSLTSVSDHLKEIIHKEPEHKTRVFAAIVEMLRWFAGHQIRNVATIGGNIATSSPISDLNPLFMAAVCTIELSSKSGKRTVSMDGNFFTGYRKNVIKTDEIILAINVPFTCENEFFYGYKQSPRREDDIAIVNAGMRVVLTPGTNEVQDCSLSYGGMAPTTVLATKTMKNITGRCWSDGLVEAMTPFLLEDLPLTPGAPGGMEPYRQSLTLSFFFKFYLAVLEQLRLKQPGLISGSAVPPSYKSANQPYHKNSARGVQLYQEVPSGQPDSDAVGRPLTHQSAFKQASGEAIYVDDMPPIKGELYLALVMSRKAHANILSVDTTVALALNGVHAYVNADDVPGNNLLGSSPVYDDVLYADKTVNFVGQVIGVIVADNQAIAQRAAKLVRVEYEELLAVFTIEDAIEQNSFFPVSRCIQTGDLDQGFETSDHIIEGEVRSGAQEHFYLETWTTLVIPGEGGEIEVISANQSPSRTQSLVAEALGIASHKVVSRVKRLGGGFGGKEARACLHAAVCAVAANKVKRPVRLMLDRNEDMMISGTRHPFLARYKVGVTSYGQLRALEVDLYSNAGSTYDCSPSVLERSMQHVDNCYKCPNVKVTGHMCRTNLASNTGFRGFGSPQAMLVAETIMSEIALKCGLTQIKVRDVNFYKGGDETFYGQELKHWNLDKCWDQCLVQSDYDNRRLDVDEYNRKNRWRKRGLAITPTKFGISFIVKYYNQAGALVHIYNDGSVLVSHGGTEMGQGLHTKMIQVASKTLRIPQEKIHINETNTSQVPNTSSTAASFSSDLNGMAIKEACETLLHRLEPFIQDNPKGTWESWVDAAYKDRISLSSTGFGRARDLYFDWEKGKGDPYAYFVYGVAVSEVEIDCLTGDHQVQRTDIVMDVGDSLNPAIDMGQIEGGFIQGYGLFVLEDYRVSPSGQLLTTGPGFYKIPSFGDIPAEFNVSLLTRAPNPLAICSSKAVGEPPLFLAASIFFAIKDAIQSAREDAGIPRAFRLDSPATAERIRMACQDQFTKQISTPEEGTYKPFFLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3H1</accession>
    <name>A0A913Z3H1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046376.1">
        <property type="nucleotide sequence ID" value="XM_038190448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046377.1">
        <property type="nucleotide sequence ID" value="XM_038190449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046378.1">
        <property type="nucleotide sequence ID" value="XM_038190450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3H1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190448.1">
        <property type="protein sequence ID" value="XP_038046376.1"/>
        <property type="gene ID" value="LOC119720661"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190449.1">
        <property type="protein sequence ID" value="XP_038046377.1"/>
        <property type="gene ID" value="LOC119720661"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190450.1">
        <property type="protein sequence ID" value="XP_038046378.1"/>
        <property type="gene ID" value="LOC119720661"/>
    </dbReference>
    <dbReference type="GeneID" id="119720661"/>
    <dbReference type="OMA" id="ACVINPV"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="432" mass="45741" checksum="2AF9D50285C1AA71" modified="2023-02-22" version="1">MANALSYREGGWGWVAVFSAFLAELIVYGSLKAFGVLITSMKEDFQTNLWIVGSICALHFGVQFVLTPLATAAACQYRSRVVITLGGVLYGFGLVISSVVQNIVPFAVFLILIAGSGAACTLETTRAEVAFYFQEKYAVASFLALAGGPIGMMLYGPVTQVLLETYGWRGALLLIGGTSFHLICSGLLVRRPTRVYAKLLDDCTDPGPDNGPSSSQTDRCLAKLSKVIAGTLGLDLFLCLDFLLLAAVRLFTNACYGGILVYMVPNGLAVGLSPSEAALLTTVFGVGSLAGLSLTALVLHTEVLSCHATGAIAGCMTVVALALDTFISTPIGHMANTCIIGAGIHSIIQVTSVLTRGLPYGDDRFVVVLGWQSFLAGVATSGGDTLSGWLYGATQSFHGTFFMYSAFMTATVLFLLVDFIRAFITTRRRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z415</accession>
    <name>A0A913Z415_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 223</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046534.1">
        <property type="nucleotide sequence ID" value="XM_038190606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z415"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190606.1">
        <property type="protein sequence ID" value="XP_038046534.1"/>
        <property type="gene ID" value="LOC119720767"/>
    </dbReference>
    <dbReference type="GeneID" id="119720767"/>
    <dbReference type="CTD" id="79064"/>
    <dbReference type="OMA" id="PLEHISC"/>
    <dbReference type="OrthoDB" id="5950063at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026100">
        <property type="entry name" value="Tmem223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29096" checksum="6E86E2D1B7310D1A" modified="2023-02-22" version="1">MLLGRATAIGANKLVLLFPRNGSSAPTSMMTTLTRRLVQPLLSCSGKTLCRDSGQYLSMQLRQISNHSKTLVDKNILIYRNDGFTFFRVVGVFALAQLGFWSYLTYSAYTSMTDSRKFELAKYGPEGAPSDKKNWTTLSGIRMKLHSGVWRYAITALCVVVGGVIFTGALTYSKKCIHRIVLRKGGDRITISTFGFFGQPWSFTVPVTNVSCQHSRHGVRTQLPIKVKGHSFFYLLDKEGKLYHAPLFDQTVGMKRMLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4I3</accession>
    <name>A0A913Z4I3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Spondin-like TSP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045644.1">
        <property type="nucleotide sequence ID" value="XM_038189716.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045645.1">
        <property type="nucleotide sequence ID" value="XM_038189717.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189716.1">
        <property type="protein sequence ID" value="XP_038045644.1"/>
        <property type="gene ID" value="LOC119720157"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189717.1">
        <property type="protein sequence ID" value="XP_038045645.1"/>
        <property type="gene ID" value="LOC119720157"/>
    </dbReference>
    <dbReference type="GeneID" id="119720157"/>
    <dbReference type="OMA" id="GRDCMDP"/>
    <dbReference type="OrthoDB" id="5814848at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000120">
        <property type="entry name" value="Thrombospondin, type I, domain-containing 7Ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF30">
        <property type="entry name" value="SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324081" description="Spondin-like TSP1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="7">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="7">
        <location>
            <begin position="578"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="7">
        <location>
            <begin position="707"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1496"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1604" mass="178613" checksum="04C6E46D20C8C085" modified="2023-02-22" version="1">MDTLCFLVLPVCLELIFAPLAGAIGGMFGDSSTSFSYSWSTGPWGPCNGNQCGFAGSQTRHVWCTHPVLGTQPPSKCDQVTMPESRRNCFKVCEEHRHLFAWLAGDWEKCQRTVDTGPLECGETSLGMKSRAVKCVDTSTGFLKEETREVVPQYICEQFEIKPPTEMECFTPCPQNCIVGAFSKWSECTSTCGNGTQTRTREVVVPPIHSGRSCPNLSETRMCKNNPPCESNEFTYFTKVGTWMKCQPPARGTGNNRLPGIGLQLRTVSCLKNNGEKVDDGLCYQYENENSLVPSKFQSCLVPRDCATTSWSTWSTCPNPCKSRPDPESGTVYKERKRSVTVAPLGGGTLCPKLVERLACPASDEPRRLECPTYVWHSTEWSDCSVDAVLSPYEKLHFGNDEPLCGGGMHQRDVFCTMLNDTGTDLAPVSPSLCNPNTKPELISPCEVPCPSTCQVTPWSQWSDCISEQCSPENNKKLKGHKIRTREVAVEAEDGGEDCPHLTEYVPCDIAICFKWHAVDSGECIPADSTARCGQGEQELNITCLDMNQNVVDEDLCSSISPKPETQVQCWVPCPNDCVVGEWGAWSPCSMVCGKGGVQTRYKNIRAYPGPGGYECPMPQHLIETRACNDHSCAHFAWRTEKWSECISGLRPVQLEGVEGMCEVGRQTRTMECYRTLQDKVAPEKRCGEQGKPASVRECYIPCPQDCRVSSFGEWSACPQSCETGMGFLHERDRFVLQPVRHGGQPCPQLQERQVCPVPDSCYSYQWVPSLWSDCQLPLGRQRGSWDPCGDGLKTREVQCQREGGMPVDVDLCLRYGPPMPAAAEKCRILCEGECELTEWPRWSVCTDNCNGRRNRKRRLIGQSRRTPECDNPEIYPLIEYQPCRCHTYTLEPMGVWSNCFIEPSQFKVSPEAGGLMGDSAGGVSGGCGLGVKYRAVMCLDEERRIVDVGKCGAETDFTVEMCDILCPEDCELSPWSSWSECSETLNVGQRVRWREILQEGSEVGRPCPIPDRGNRMYQRMPCRSDAHSRLLWYTGTWHECEMPLNGSCGDGHQRREVRCKIDGPPGFYGPDNSSSLCDHRFRPPMTRSCSKPCPGECAVSDWSEWAPCPQDCENVSFHTRTRVVLRRPTSSTEGSITCPPLTQVEPCNMGDSCVTYRWNATDWGSCVMEPRGACGTGKKIRLLQCLQSNGLEVENSICDKLDLPKPETLEASCHVECPGDCILSPWTEWGKCTQACGHSVGRTRSRTVLRSANSLGRPCASSLYQWRPCKPSPCYRWVTGPWGHCLPRGGDCGIGWRQRNVTCQQEDGVLVSEELCQTGIYQSNINVTELGRERLEREQPCNIPCPSECQHTQWNTWSDCYVSCLQGRTVGNEGIQVRSRAALGPDSGCPTDQLEIRPCSGETCYEFLWQTGPWRKGKREVWCQRSGGLNVTGPCLMDMKPSTMVICEPDCTVMHSFCSEDNMCLCKLGYAAKFSETTGELIECTDEWIMIQDGDGEHRTPDQTVGSNQPNQAATTENNTVAKGKEGDAESKGFFESIPPWGYAIVGCVGLLILVIIIVVAIVYGCRNAKRKEEEKRKYQHAADYSIYWDDNAKKKYNGEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z598</accession>
    <name>A0A913Z598_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045935.1">
        <property type="nucleotide sequence ID" value="XM_038190007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046009.1">
        <property type="nucleotide sequence ID" value="XM_038190081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046082.1">
        <property type="nucleotide sequence ID" value="XM_038190154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046164.1">
        <property type="nucleotide sequence ID" value="XM_038190236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z598"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190007.1">
        <property type="protein sequence ID" value="XP_038045935.1"/>
        <property type="gene ID" value="LOC119720326"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190081.1">
        <property type="protein sequence ID" value="XP_038046009.1"/>
        <property type="gene ID" value="LOC119720326"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190154.1">
        <property type="protein sequence ID" value="XP_038046082.1"/>
        <property type="gene ID" value="LOC119720326"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190236.1">
        <property type="protein sequence ID" value="XP_038046164.1"/>
        <property type="gene ID" value="LOC119720326"/>
    </dbReference>
    <dbReference type="GeneID" id="119720326"/>
    <dbReference type="OMA" id="ADEFNSP"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000025">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="272" mass="30094" checksum="7B3839F040902FC7" modified="2023-02-22" version="1">MADSYHDHMDDLVSDQHDRGLKRPLDTTSTSASDESADEFSSPTSQKRMKFDDLGSPPEPHGLLSALGDFSSAGRNKDMNRQAGSLESVTDDTAKQPASTEQPHQEQAVETEAKSEGQPSDLGGSKEGDAEGDREGEKPAGPRLERSLSAAEEHKLKEQIEEEMRQKKQILVDSLSEAQLNRYEMYRRASFPKAAVKRYMQSITGCSASHNVVIAMSGIAKVYVGEIVEAALDVLEQWGDTGPLQPKHIREAMRRLKSQDKVPSEKRQPLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5X8</accession>
    <name>A0A913Z5X8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047134.1">
        <property type="nucleotide sequence ID" value="XM_038191206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5X8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191206.1">
        <property type="protein sequence ID" value="XP_038047134.1"/>
        <property type="gene ID" value="LOC119721236"/>
    </dbReference>
    <dbReference type="GeneID" id="119721236"/>
    <dbReference type="OMA" id="IHCNTPN"/>
    <dbReference type="OrthoDB" id="6147043at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="25299" checksum="34886E2C3A0B0395" modified="2023-02-22" version="1">MRPAGSSRSLPSVPQARQPYQMSVSDDGSVLRDSTPYRLPKIQQQLAHRLPRTERVTRSEPTDLDQLYKVDYVGSDRMEMYLSKRHKLPGPPYTISQRHRQEGIHMPTFQKVQFEPVLPCNRVVEANGHAELERSTSRTSLSTRDTVILGLGRHVAGTQQESPPAVDKHSAWRLSPHKHKNYDIQAIQGQTGPFSRDFVIHCNTPNSWLQMKLNKQKTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8L3</accession>
    <name>A0A913Z8L3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048082.1">
        <property type="nucleotide sequence ID" value="XM_038192154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8L3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192154.1">
        <property type="protein sequence ID" value="XP_038048082.1"/>
        <property type="gene ID" value="LOC119722120"/>
    </dbReference>
    <dbReference type="GeneID" id="119722120"/>
    <dbReference type="OMA" id="VIEMIIS"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="759" mass="81344" checksum="A9E05442F7E00557" modified="2023-02-22" version="1">MGRKRKENAAMDLEPEPPDSGWAWVVLCSVFVGQFLVIGFLASVSVYVYVWIAFFNGSAAETSLVISLCTFMMGVLSPIAGSICKRFGPRVTVMAGGTMTCVGLVFSSQATGIIFLIISLGLFTAFGISMTFNAGFTVLGMYFKKRLAMAIGLATAGTSIGQLALPPLFQYLIDQYGWRGSLMITSALAFHVVAAGALMRPLVPKKQKRSSKRSKRSELEDKTSDATPNKNCQSTEVGSTGLSFLSPSIFGGEDFVCSPGAGDTTLGEGSIFQGKPDVAMTIDETEDEDRIEYTDSDSWSLSSTSEGDMTAMNNNVWVPVAITTLGNLPKERRRSYFRRRPRSASMVSQTLVKKSSDLIRLLRNPSFLVLMAVSIGNGFGRASTTYHLVSRAESINIEPDNAALLLTLMGAGSLIGRLSIGWIVDRNWMRPELCYTLTFGVCALATFITPLITEFKVLVAVALVHGASSGAATVVVMMTPRLVVKPWLASTSMAYFLLAWGVGEISGGALAGWFYDALKSYDYSFYAAGSVMTSASALMLIIYFLQRAKRRRQGHHAKSFGEQAGSVQPGSNQLDPELAGSMHDDLGRVNPVFSTRKGFETCIDLCEGEIMGESVSVCEADVDLEGSEWSLKGQMVGGSLGEGCNDVGESLVCKSVPVSEVDAVQLASQSCQSNAACNRERSELSQTGQTVGGSVGEGCNDVGESLGIENPINENDSDEDHANYTLSSQSDTHAEVHKKEIGLDENETPGSVTGPSQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9J5</accession>
    <name>A0A913Z9J5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047560.1">
        <property type="nucleotide sequence ID" value="XM_038191632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9J5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191632.1">
        <property type="protein sequence ID" value="XP_038047560.1"/>
        <property type="gene ID" value="LOC119721552"/>
    </dbReference>
    <dbReference type="GeneID" id="119721552"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036745395" evidence="1">
        <location>
            <begin position="28"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="36331" checksum="FFFCE4EF3F9D5E57" modified="2023-02-22" version="1">MGRAWTWLVPPLLAVALHLVCYTPVLSQNFPNEFCSAVQLNSSNQVVVISDGSLTLCLNVTAPPGTAIRATLHRSVAIVFDYSVCAFSFDGFEFFSTRCREKIEVFSPRELLTMVPPYNPGSRPRFSFEAVSNEQVCGNGDHLCTFNNGSFCIGENTTCLCLTDGYCYDYEEVCPYIVLDSNQAVSISEEVGLYSEWSGDVTKGTSCWAVPVLYDIVINVTFQSSVDQFFTRITHKTFEGVLIKHYDSFVVPRTASFVNGFGLIILSAALYNESSNSTFSFNLQKNRFNIDYFGGYQEAWAIGNDDPTDKDFNDNIYDNDKNQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9J6</accession>
    <name>A0A913Z9J6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048422.1">
        <property type="nucleotide sequence ID" value="XM_038192494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9J6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192494.1">
        <property type="protein sequence ID" value="XP_038048422.1"/>
        <property type="gene ID" value="LOC119722399"/>
    </dbReference>
    <dbReference type="GeneID" id="119722399"/>
    <dbReference type="OMA" id="HEMKSYE"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000096">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="303" mass="34449" checksum="F0587D01A46F2FB5" modified="2023-02-22" version="1">MSAINRTTVEQEVHLEVKPYSHDIRSKVTGKREQHHHKRSVCDICGKGCTDNGHLILHQRAHTNKKSFVCDICGRSLSSRSSLLRHKRVHTKEKPFVCGICGKGFSNSSSLQRHKTVHTIEKIFFCDICGKGFLHSSSLKRHTEVHNNKKPFVCDICGKSFSLNSSLQSHQLVHTKEKRFVCDICGKGFPRSFALKRHTKVHTKEKPFVCDVCGRSFSLNGSLQRHQWVHTKDKPFVCDICGKGFSHMYGLKTHLEVHNNEKPFVCDICGKGFPRRFSLKNTQKGSTLTRNHSFVTFVAEASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCU9</accession>
    <name>A0A913ZCU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049344.1">
        <property type="nucleotide sequence ID" value="XM_038193416.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193416.1">
        <property type="protein sequence ID" value="XP_038049344.1"/>
        <property type="gene ID" value="LOC119722980"/>
    </dbReference>
    <dbReference type="GeneID" id="119722980"/>
    <dbReference type="OMA" id="DTNESTC"/>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF4">
        <property type="entry name" value="GEO03726P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="2963"/>
            <end position="2993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="955"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1074"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1382"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1651"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1777"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1838"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1900"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1965"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2034"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2114"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2319"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2386"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2445"/>
            <end position="2464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2470"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2807"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2915"/>
            <end position="2966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3023"/>
            <end position="3051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3074"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1209"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1305"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1495"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1654"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1777"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1838"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1900"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1965"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2034"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2324"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2387"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2414"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2503"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2566"/>
            <end position="2579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2598"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2620"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2655"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2718"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2761"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2773"/>
            <end position="2783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2836"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2916"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="3037"/>
            <end position="3046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3089"/>
            <end position="3098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3098" mass="338926" checksum="D793DF6ED1FD98DE" modified="2023-02-22" version="1">MGRRSLLANGSKKTRIEQSHLVHKNGRIKKPRELDVSQSVVMKPTSVYCRSPDDGGGTCKSTSAVSEGRRTFMHLRPHKTYTPLIGLSRRRLKTGMNHAKASAADTHLSGRDSLSLQKVHPPASHAQGRSSGAQEKSALKRVRQSETLLEMSRTTAASSNSRKNHCKGKRSQHVKQATLTCHRAWQPPSYSRLLQTMGNHRLSVTLQPLPSRSDKQHVLEASNGKASRSADTDTEADGMKTKCQLIKVEPNISSNCAQWQIDKRRLAKDMLPKNSLSRQDSQLKSKEESERTHKTAMLLRSNKKYVSVFQRKPRRSAPACVALSSTASGDQSSNCQLSFKDLQSSPSVERQTPEKHENVNEASAASLTSPEQCTTIQSPKCVHSNITPTFAMESKCNVEPTTQEVEQSSNRRVLNSGEETGSLAVLQNERGSSQGSQRIQQTDSGSLQSENKQSVMSAGELQNTLENGQVDNEKSSVLPKSRVDHKRHSTHQKLDIGDISTHGEPEISKLGGSNFALRSLLTLRPYSSYRLMAGKRLLCGTERRHWLLTQPGCRSLYHSHDYAPKVLMRLQPFTRYRRVVSKPQLHETKSRHWFLVQGVSAHSRQTMETIPDNLCEAQELSESLKSGTCSNLSNPNLPTEKTPAEDLKAVESNEFEVDESPQSIKESGSEKTLEETSATQPTKAGELDGSLSQETKLTTKHCTQKRSRQKRRKSAKNNCHAAIKSFKGVKKEQSNTDHTSASKPCRSEQIIETEENVSGQSCMAQNIASGQSCESPTCMFSTSLIDVPEIALSHNTGQRDEDADSHQAVSPAQDIVLTSTDASIQIKTQSVPDYSPKIVMMMRPYPAYQKVAGKSMLPCKFTGHWFLTEVQGSDFKREKVDDMVRNAEQKSDSLLAIKAVESNEFEVDESPQNTNPNAPAEKTPEEVLLPVELSNPSEILLPQHIQAVESNEFEVNESPLNIKQSGSEKTLDETSAPQPTKAGELDGSLSQETELTTKPCTQKGSRQKRRKSAKNNHHTVIKSFKGVKKEQSITDHTSTSPKPCRSEEIIEAEENVSGQSSMAQNIVIGQSCESPTSMLSKSPIDVQEHSLSENSHQKDKDADFLQAVSPAQDIAPSSTDASIQIKTQSVSDYSPKILMMMRPYPAYQKVAGNSMLPCKFTGHWFLTEVQGSDFKHEKVDDVVRNAEQKSDSHLEITAVESNEFEVDESPQSTNPNGSVEKTPVEVLLPAELSNPSEMFLQPQHIKEVESNELEVDKSPQNTKQSGSEKALEETSAPQLTKAGELDGSLTPETKLTTKQCTQKGSRQKHRKSAKNKYHVASKSLNGVKKEQSIMDHTSKSPKSCRSEETVEAEKIVSGQSCMAQNIVSGQSCENPMLSKSVTHDLSQNTRQRVKDADSLHLGKTVQTRSLTQKLERPKRRLKPTEKSLLHQLAKAVKTCRHSAKPTLKLKTVRKPTKKSPKPEFGKKSSNSKSKQRAVFATKILVPSRQSSGPDLRADATCTEREPDSTHPSLLQETSDESVSVIQSQVGLSQGLGDCLKVDKVTGDKKATLAKQNRLHKVCLDIQVRGLSQLHHLISIANQISTMPSAIPDSDTTSGNDNLTTEEQCTDSEVVLDSKPQVVDTMQVDDTNESTCVTDVAVSSPCLSTMPLAISDSNKTPGNDNQTTEEQYTDSEAVLDSKPQALDTMQVDDTNESTCTTDITVSSPCLSTIQSAISDSDTTLGNDIQTTEEQYTDSDAVLDSKQQAVDSMQLDDTNESTCAADVTVSSPCSSTIPSAISDSDTTLGSDNLTTEDQCTDSDSEAVLNSKPQAVDSMQPDDTNESTCATDVTVSSPCLSTMPSAISDSDTTLGNDNQTTEEQYSDSEAVLDSKQQAVDTMQLDDTKESTCVTDVTVSSPCLSTIPSAISDSDTTSGSDNLTTEDQCTDSDSEAVLNSKPQAVDSMQPDDTNESTCATDVTVSSPCLSTMPSAISDSDTTLGNDNQTTEEQYTDSDSEAVLDSKQQAVDTMQLDDTKQSTCATDVTVSLPCLSTMPSAISDSDTTSGNDNLTTEKQCTDSDSEAVLYSKPQAIDEMQLDDTKQSTCATDVTVSSPCLSHMESESISVEDMISTTDGMQSHTEKDHNSMPEQEEHQDESSRDFLTEDAANITTEKNKCFADSPIPIFSGKEEEKNKPGTEVLNLTKGRQAKPRRRTTMRLRKKDKHFLFSRLGFKKTKRRAFHVVHNNKHGRGRKPLTVRAGETNICEQGKGLNEHGTEISQGILGDPGSSALPSCTHRLRKRRANVFRLTHVMFAAASQKPSPSANPKTKPTIGRPRKLTHVMSAAASQKPSPSVDPNTQSSRGRPRKPTNVMFAAASQKHSSIADPNTKPTIGRPRKLTDVMFAAASQKHSSIADPNTKPTIGRPRKQTHVMSAAASQKPSPSVDPNTQSSRGRPRKPTNVMFAAASQKHSIADPNTKPTVGRPRKLTDVMSAAASPKRSPNAGPNTKSSRGRPQKPTHVMFASASQKHSSIVKPNTKPTIGRPRKLTHVMPSAALQKPSPRADPNTKSSRGRQRKPTHVMFAAASQKHSSISDPNTKPTTCIGRPRERTDVMFAAASQKHSSIADPNTKPTIGRPRKQTHVMSATASQKPSPSVDPNTQSSRGRPRKPANVMSAAASQKRSPSADPNTKSTIGRPRKLTYVMSAAASRKPLPSADPDTKSSRGRPWKPTHVMFAAASQKHSSIANPNTKPTRGRPRKPTDVMFAAASQKASPSADPNTKPTRSRPRKRKLSPHENSSPTNNILPSLHTCRRGKEFCTTELPSNVQLDLQHHRQQNSRSIKLQDKLDDANSNALSKPRGRKRKKRVFPKRKGDLQSPGTNLSRDAPPACMPASSPDHLPPAKRIKQLIPGYVSPDKEEFTLEEFCSLKTLEEAVEMAARETSNDELPHLSPVSKRKMKSSDSKLHRVSSSSNKKSRAKRSSRSPEGSYWDCSVCTYRNKAEAFKCAMCDVRKGTSTRKPRLNAQLVAQQQAQQNLSPLVHVKTVKPAPRSSPVQRKTGSPKKPRPRLKNIDRSSAISTEVVVNNVPVIITEYKEKSHTRTTVDSDEASADRTNGNVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZED2</accession>
    <name>A0A913ZED2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050146.1">
        <property type="nucleotide sequence ID" value="XM_038194218.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050147.1">
        <property type="nucleotide sequence ID" value="XM_038194219.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050148.1">
        <property type="nucleotide sequence ID" value="XM_038194220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZED2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194218.1">
        <property type="protein sequence ID" value="XP_038050146.1"/>
        <property type="gene ID" value="LOC119723517"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194219.1">
        <property type="protein sequence ID" value="XP_038050147.1"/>
        <property type="gene ID" value="LOC119723517"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194220.1">
        <property type="protein sequence ID" value="XP_038050148.1"/>
        <property type="gene ID" value="LOC119723517"/>
    </dbReference>
    <dbReference type="GeneID" id="119723517"/>
    <dbReference type="CTD" id="84984"/>
    <dbReference type="OMA" id="AKKCGIQ"/>
    <dbReference type="OrthoDB" id="2163581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="18639" checksum="58B2DFDF27B20D0E" modified="2023-02-22" version="1">MSITPKKCAIRVDPPTLVLTYTDEVTGKDRQRSMPLRNFTKRSGVDRFVRELKANPRHKKYLENVSAIQLEKLLSIIKERLSGLSMEESLEKVKKELSVDPDEDLNQLDDQALQKKKSIMDETFEKNRKKPGEEGFQYDVDVDFGGGIESSGWDSGEESDPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFX0</accession>
    <name>A0A913ZFX0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050329.1">
        <property type="nucleotide sequence ID" value="XM_038194401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFX0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194401.1">
        <property type="protein sequence ID" value="XP_038050329.1"/>
        <property type="gene ID" value="LOC119723637"/>
    </dbReference>
    <dbReference type="GeneID" id="119723637"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23721" checksum="3F8310F2ED8482AF" modified="2023-02-22" version="1">MQQRSAATEDNFDLVFGVNHFGHFLLTNLLLDLLKKSSPSRVVTVSSAAHYFAAHYFAPEPMNLTHEDPAVASLLYPHLEGYGISKVANIQFGRELARREVSSGVVSVSLHPGTIYTPIIWKNLMTAETDLVWIKTLYYTLSPLMWLFFLDEEAGTQTTLHCALDDSIPQLSGSYFDNSQVMAPSALAEDDELARRLWQVSCEATSLECTSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFY3</accession>
    <name>A0A913ZFY3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038049900.1">
        <property type="nucleotide sequence ID" value="XM_038193972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFY3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193972.1">
        <property type="protein sequence ID" value="XP_038049900.1"/>
        <property type="gene ID" value="LOC119723370"/>
    </dbReference>
    <dbReference type="GeneID" id="119723370"/>
    <dbReference type="CTD" id="56922"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="45"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="164"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="632"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="78707" checksum="F84005A9D1E71C6E" modified="2023-02-22" version="1">MATIMRASRLLVATDVLRQGRNTGRWFKINSQSSCRQLSDVATMPISKVLIANRGEIACRVIRSARKLGIKTVAVYSDADKHSMHVAMADEAYHIGPAASQLSYLNKQKILQVAKSSGAQAIHPGYGFLSENTEFADLCDKEGVIFVGPPSSAIRDMGIKSTSKSIMSAAGVPIIEGYHGTDQSDDRLRAESEKIGYPVMLKAVRGGGGKGMRIVMTAADFDEALESARREALKSFDDDVMLVEKFVDTPRHVEVQVFGDRHGNYVYLFERDCSVQRRHQKIIEEAPAPGLSEEVRRSIGEAAVRAARAVNYVGAGTVEFIMDSQQNFYFMEMNTRLQVEHPVTEMVTNTDLVEWQLKVAGGDPLPVTQSDLRLHGHAFEARIYAEDPDNNFLPGAGPLVHLSPPSGDQTIRIETGVRQGDEVTTFYDPMIAKLVVWSADRTSALEKLRHALREYHIVGLKTNIRFLDDLAKHPEFIKANVHTGFIPLYEDQLFSRKGPLNRQTLCQAATALVLFEQYKGQKEAVDSGDPFSPFSMGSGARVNENFIRRVAFTDKDDNIDVTVRYQSDGSYVVQIGDESFDVQATLTQIEDNTAQLVSTINGIKADTKVVMHEGAVHIFAEVGGVEVTRPVPEFLGDSSSGTMGDRAPMQGDITHIYVDPGAAIEKGDPLLALESMKMEYVIRAPKKGIIERVLVAKGDNVQKNAPLVVYQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIZ9</accession>
    <name>A0A913ZIZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptor GRL101</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051025.1">
        <property type="nucleotide sequence ID" value="XM_038195097.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195097.1">
        <property type="protein sequence ID" value="XP_038051025.1"/>
        <property type="gene ID" value="LOC119724165"/>
    </dbReference>
    <dbReference type="GeneID" id="119724165"/>
    <dbReference type="OMA" id="CANYLDE"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1297"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1388"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1464"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1512"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="641"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="801"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1277"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1628" mass="179374" checksum="AF58823BB1A08B1C" modified="2023-02-22" version="1">MDGQFLCDTGIQCVNTSMRCNGWPDCEDYSDELGCSVACGPGQLSCTFASQDVCLSDSQICDSTKECDNFLDEISCTSGCGDQNIQLQPNRTHTLASQNAPTAHPAQFICVWFVTAPPITRILVQTLRINLNPGTNLTVGDGPSVNMSHVVWNRQGGTAPSHAVSRSNEIWIAFEDAQEISAFSQPAIAVGDAHFVLDLSILEDFVNCSDGDQFACKDGYRCISSSEVCDGVVQCFDFSDEMSCTDECPDDAARCVDNEGNHVCLNKGDFCNGLENCANYLDETLCSNICGERYINLEEYPDFTYSLSSPDNGFPPQTACLWIFTATPGLIIQMDLVQQFIGSADFFTFGDGTNPSNTSSIISYLPGNHYPIASLHPNGLWMTFAATSGELGSFLYRISIFNTTVSCREDQFQCSVSGLCIDASKHCDGVLSCNDNTDETGCEHCNGISTFNVTNGQSFVLQLSYEPDDVNFPFGRNCVWYVTASAGHRIKITYREYMLSEDNALYFGHGAVLESNAETVSSHSTYTKLHIISETDNLWIALISTSMTSANRLNLEIEELRPVECNDDEFACPSGLACIPQNQVCDGYPQCPMRGDEIGCGPCSEQQYRCPEGSCIDALEQICDGTAHCLDLLDEMNCFPCGESVVTLNNSTHTSATLASLNYPNDYPDYALCAWLITADVGSTIALRFSAFNTERHYDTLTIGNGHAPSDGISVIGRFSSSLTSLAVFSKDHTAWMEFKSDYSLNEIGFEVTITQERSQASCRQDEFACQDASSGLICLARDDTCDGFALCPDRSDESNCGECGPQNIYVYEKPFTLTSPMYPGGYPNDLNCIWLIKGELMTPVTMRIEDFEMEDGFDYLKVVFLGEGERPEELFRLTGADVSRRTVTWDHDAGVLKLQMKTDRTTGRRGFSLLISHYQNFTEEFEEGDLEALCEPDEFHCGNGFCITNSSLCNGYLDCVNYEDELDCNDVFCPGSYKCDNLNTNQTYQPPTRPPTRPPEDSGSSSSDSSSPSSDSSSSSSDSSSSISVADVLPQAQCIPRAQVCDGEENCPESDDEIQCDVKRCPTGCKCSYKDADLVVNCTNGWDSSTLADLALTTHTLQLSGVNISKLDQGMFKGISHLKVLSLRGNLISEIQERTFDGLDKLLWLDLSKTSISELQGSAMEELSRLRGITIFDVPLLRIRKDAFSGLGQVKTLIIVRKIKGLPPLEVEDGAFKGLDDVSELYVDNHRLCCFFPSAECKTLEPQPPLFMCSELMPRMVLKAFMWILGISALVGNIFVMVWRCREKTEGRASRVVHSFLVFNLAVSDALMGLYMLIIASADAYFGERYFEVSMEWRTSPMCKIAGFISIIGSEASVFFLTLISIDRFLSIVFPFSIYHLRPKSSRIAASCVWIGTVIVGLVPTILATDSSSDVYGLSDVCIGLPLMTKVTEYETVDQQIDAGGVANITVGIPSPVDYRASWFFSIALFLGVNLLCFTVILICYIAIFIQVKASIKRVRRHKKRDDEVRMAIKMAAIVMTDFICWIPVIMMGILSQARVVEIPTEAYAWIVVFILPINSSLNPYLYTISDMCSQQRKSASVRKSGLPMKDSHSNSENRISGIVNSVTIETQIDSKADHGNNKTMHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKY4</accession>
    <name>A0A913ZKY4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051750.1">
        <property type="nucleotide sequence ID" value="XM_038195822.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065986.1">
        <property type="nucleotide sequence ID" value="XM_038210058.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071109.1">
        <property type="nucleotide sequence ID" value="XM_038215181.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073433.1">
        <property type="nucleotide sequence ID" value="XM_038217505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195822.1">
        <property type="protein sequence ID" value="XP_038051750.1"/>
        <property type="gene ID" value="LOC119724666"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210058.1">
        <property type="protein sequence ID" value="XP_038065986.1"/>
        <property type="gene ID" value="LOC119736054"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215181.1">
        <property type="protein sequence ID" value="XP_038071109.1"/>
        <property type="gene ID" value="LOC119740001"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217505.1">
        <property type="protein sequence ID" value="XP_038073433.1"/>
        <property type="gene ID" value="LOC119741665"/>
    </dbReference>
    <dbReference type="GeneID" id="119724666"/>
    <dbReference type="GeneID" id="119736054"/>
    <dbReference type="GeneID" id="119740001"/>
    <dbReference type="GeneID" id="119741665"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="18263" checksum="534DD4D729DAC8E0" modified="2023-02-22" version="1">MKTNILHSVSLIFQVFIQNTLWKLAFTSRAFAAGEPAVTGQPAAAHFLTIELACLLFTKCTALWSRQEPFLEKATYRGNSCVHCRQQPPSPSSCNAGVVKTNLERHVGSGSPSSSPRLWNFGEQFCLVSAEPTLLAGQYLGHSQTSSLLSIWHQCGPAAAIRMCALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMW3</accession>
    <name>A0A913ZMW3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052445.1">
        <property type="nucleotide sequence ID" value="XM_038196517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMW3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196517.1">
        <property type="protein sequence ID" value="XP_038052445.1"/>
        <property type="gene ID" value="LOC119725156"/>
    </dbReference>
    <dbReference type="GeneID" id="119725156"/>
    <dbReference type="OMA" id="IFRSEMA"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF78">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="418"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="705" mass="78719" checksum="552E61DE1FD78F26" modified="2023-02-22" version="1">MRGSRLHRLALRLLLVKIEKMLLLVAVALTVAVTPCLCQSNVTKLYLLGLFPESGPWAGAETALPAAQLAVDDINGNPDVLPGYEIVLIPRDTECNGGKATDIMYRELYNTSTTKTMIIGGGCSLATEPTAQASHFWNLIQISYAASSPKLSDRLLYPRFFRLYQPETTFNLAKLTLIKKFNWTKVATIYESLPLFSLTFAEFHHEAKKAGIEVIAQETFGDDPTTQMEHLKESGTRIIVGGFYSDAARKVFCAAYHLKMFGAKYVWILPGWLALNTWLVPDDTIDCSLDQLKEVAGYQFGVNALSLLPDTHQTLSGMTTSALLARFNASVGTDDPESLVGFAEIPFSYDTIWTAALALHEAEQQLEQLDPPKTLADFTYDDNTTVQILFDVISNMTFQGVSWERYSYVELPFVYSSVIKMSSPNINNVMLIGGMLAYVSIIFLGVDTNIASTDTFVSMCRVKTWFLPIGFSLAFGAMFSKTWRVHKIFTNKTAMKRVVKDKWLFGCVAVLILVDVVILIVWEIFDPLEAVERIGATKIDDGNDDIVYTPIRMMCESRNQTYWIGAFYVIDGLLLIFGAFLAWETRKVSMPALNDSKYIGVCVYNVLILSFVGAPVSFILEERNAHYALVATLIWLATTLTLCVVFVPKIRMRNEVQPAQSALVTQLTQCHPSGHSPATEEVQRLRQELNKMKGHLDNLGIKYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN34</accession>
    <name>A0A913ZN34_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052461.1">
        <property type="nucleotide sequence ID" value="XM_038196533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN34"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196533.1">
        <property type="protein sequence ID" value="XP_038052461.1"/>
        <property type="gene ID" value="LOC119725172"/>
    </dbReference>
    <dbReference type="GeneID" id="119725172"/>
    <dbReference type="OMA" id="MPGPWAD"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="364"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="485" mass="54528" checksum="4E49BE58EEBC443E" modified="2023-02-22" version="1">MKRTFVGVCDEEIPLSNSTTWQLNKLGGYPDWMYSDCNYPPCNVCGDPLYHVAQMYCPLEASSYHRTLYIFTCVTKSCINKKESWRVFRSQLLLSHIASSKQVTKKSPKVVAMVMDEWCEDADDWGSEPEEEIHNEHVKSSASNDAQDKGGTKPSIRCHPSGDAVAMAMDEWCEDADDWGSKSKKESHNEQIIPSASNGAHDRGGAKPSLECHPSGDAVPMVTRLLQDSTSNDEILTRATAKLAGQDLDEDTVKEQSEDVDPSDAMTRLSISTPSTQQTSKDSNSVLSRSRHHAFTGYFVNVFDEPSPCTSVTELTNHERELIADYQQREGVDLLEWQEEHLQMMSKVSSCEESYEKTSAKHGDKVFQRFAKRLQLCPEQCIRYSWNGTPLYLTSPSEGTLIPSCPHCGSQRVFEVQLMPQLINALHDADQPGIQIEFGVVIIYTCKANCWDDPCQPGQLNLREEYVEFQVDPDSTLIAKSKFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNQ8</accession>
    <name>A0A913ZNQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052681.1">
        <property type="nucleotide sequence ID" value="XM_038196753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196753.1">
        <property type="protein sequence ID" value="XP_038052681.1"/>
        <property type="gene ID" value="LOC119725355"/>
    </dbReference>
    <dbReference type="GeneID" id="119725355"/>
    <dbReference type="OMA" id="EINHAHA"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="240" mass="26317" checksum="4E9C47A7ED20DED4" modified="2023-02-22" version="1">MTGGPAETTGDGHAHGAGGRERSMSASGESLYAILGVEKGADNDALKKAYRKLALKYHPDKNRDDPTAEEKFKEINKAHRVLTDAKKRQIYDDYGSVGLYIAEQIGEDNVDLYFLVNSRCFRVCCGVCFFVTCYCFCFCCCLCCCGCCGKCAPKEEEYTEEEFEEILRGMQDNEIGDPAVRDVEVTITVQPGADASAARSNIHDVPPYKTAIPMPAPEATEKTSLKAAEVVNTSYVVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP41</accession>
    <name>A0A913ZP41_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053507.1">
        <property type="nucleotide sequence ID" value="XM_038197579.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038197579.1">
        <property type="protein sequence ID" value="XP_038053507.1"/>
        <property type="gene ID" value="LOC119725955"/>
    </dbReference>
    <dbReference type="GeneID" id="119725955"/>
    <dbReference type="OMA" id="MICEMPA"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01756">
        <property type="entry name" value="PLAT_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="175"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="309"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="440"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="569"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="699"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="827"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1711"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="1879"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="2010"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="2137"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="2269"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="2412"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1834"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2532" mass="285192" checksum="88FF61CF8ED83177" modified="2023-02-22" version="1">MNSVSVWDAMASGSTAVARPIRTLDPRPPYAVDRPRPQSAPIRKPVSPPKPLWRDSRSDSIPHKQRRFTTSLRSSSANQDSYVSKRAPFAAKRLHALNVERQMMTGTYPRVENGRTVAAPEYDPFADPHLTDYFARKFSIGLPRPPSGAKRRPASANGRTSSTWNGGRHSAASECMYRVTVKTGDKKNCGTAANVFIQLKGSKGKTAKRKLSKKSAKTQSGFMKIKYSRNTSKVFKLKMQDVGELQTLTVEHDGLEKPDSWYLEEVEVTNLSSKQTWLFHCGQWLSLFETDCQLRRVLKALDPKKHGKTEYEVVTITGDVKGAGSDSSVYITLFGMRGTSKKMPLKPRQGVDPFERGNSDIFTFKCNNVGPLRKIRIEHDNTGFAPGWFLDRVVVTDLSNPKKGKYYFPCGQWLAKGEGDGLICRDLMGSRDPLAVRKSHKYKVHIFTGNTRGAGTDANVFVTIFGESGEDCGEKKLTSSKNNFERGREDVFVIEAQALGPLEKIRIGHDNSGPGPAWFLDKVIIDDVEMGTTYEFPCKRWLAKNEDDGKITRELYCGDKAGKGSEKGIPYEVRITTSDKRGAGTDARVYIVMHGGKKGEETSGKIWLDDGKFERGRTDVCSVEIGTILSPLSRIDIGHDNAGVGAGWHLEKVVIDCPAAGIEQTFLCNDWLADDEGDKRIERTLTENKSMRKTKKQKEVWNVTVCTSDVPSAGTDANVLFCLYGDQGKSDEIRLENKSDNFERGQQDSFKIEMVPVGKPYKMRVWHDNKGMAAGWHLEKIDIQRVSSKKSFTFPCNRWLAKSEDDGEIVREMPATGDSIKKPLPLVKYKVSVHTADKFGAGTDANVFCNIFGELGDTGQRPLSKSATNKNKFERKNVDEFIVEAVSLRALKKIRIGHDGTGAGAGWMLDKVVVQQEGKQDSEVVFPCKRWLDRDEDDGQIVRELVPEGNSQLLSTTSYHVSVKTGDERSAGTDANVHIKLFGEDGDSGLIPLKQSENTKNKFERGRTDKFTLEAVDIGKLEYIKIGHDGSGPGAGWFLDSIEVDIPSRGLTYMFAAHRWLAEDEEDGELEVELYPTESKKSKARIPYEITVTTGGCSGAGTDANVVLRIYGEDGAKTEEFNLRNRTDNFEKNSVDKFKIEAEDVGPISKIRIGHDGTGRFAGWFLDRVQIERFPPKRRLKRRKSRSKTRPPSDEDDDSDNNRSKRRRSKSKSRTRSDEDEKSDDGKEVDESQETTKYLFVCNRWLARSEDDGQIVRELVPTDESGNVLKKNSLKMCDYVVHTYTGDVFQAGTDANVFVNIYGEKGDTGERRLKDSETNTNKFERNQEDIFKMEAGDLGGMKKLKIRHDNSGPGANWFLDRVEVEDKMHNRRYYFPCQRWLATGKDDGQISRDLIPVEKEVIQRSLSRRRSSTSVREEIALEAKASMETYHVFVTTADVRGAGTDANVYIVLYGENDDTGQHFLKASKTNRDKFERGKTDEFIIEAVDIGQIQKIKIGHDNKGGFAGWKLDKVEIDAPSLGKRWYFPCGRWLDKGEDDGQIERILHPVETRTEEYQKHVPYEFTVHTSDVSGAGTDSDVFVTLYGQEVVTGQKSLCQTKKQRKECFERNQVDKFVIELEDVGETIEKLRIGHDNAGFGAAWHLNKVEVRRLLENSKGSRTYVFPCNRWLSRKEDDGEIIRELVPAQITEEKVRKDGSMKKKEVKQDTLTMKKYAAHVYTGDVFRAGTDANVFCTLFGENGDSGERQLRNSETYTDKFERGHCDKFSFEAADLGKPFKLKIRHDNTGFSAAWFLDRVEVIDHDGEKYVFHCERWLGKNKDDGKLERSLYAKGYEGDMSSSSTLHRSKSSGSLKSVRSDSPGPLTRRKSMLEMPEFTGPTIPYTIRVITGKEADMGTDANIYIIISGPKKKHTTGRLPLQMVSKTKLEPGSIETFSLEAPDVTEIKKIEIGHDGVTPQEGWFLEEIEVDMPTLGKHVCFPCKRWLSKDKDDGHISRILVSEDGQSANYKPKIPYEVTFFTGDVQNAGTDSVITLTVFGTNGSTPEMTLDKNEERFERGKEDLIKMELDDIAPLKKIRIGHNGKGTRPDWYLDKVHLRNMETGDLTVFKCEDWLSKTHSDKKIVRELPAFVKGKAQIQNVNYKVTVKTSDIRGCGTDANVCLVIFGENGSSEELKLKESQTHRDKFERNQTDIFSYSMLSLGELIKIRIWHDNKGLKAGWHLEYVEIVDESKAQTYMFHCNRWLARDEDDKQIMRELTCVSPNTPRDDKEKITYEISVTTTDKRDAGTTQNAWLILEGDLRSSREFIMENSAKRKVLRKGDTDTFKFSTRNVGIIDSILLGHRERSDGPKPKGTGREVDWHCHEVVVMDTSLGTKYNFPCKGWVPLGFGKDSAMRLNCKKVDEGKMATTRNLAPVQYEVVVVTANEKGAGTDANVCIIIYGSNGDSGKQPLKQRFRDLFEKGQTDKFTLEVLDLGDLQKIHIEHDNKGFNAGWLCDHVTITNLATGKQTLFPCGKWLDKSKGDGELFKELYPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZP63</accession>
    <name>A0A913ZP63_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052831.1">
        <property type="nucleotide sequence ID" value="XM_038196903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZP63"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196903.1">
        <property type="protein sequence ID" value="XP_038052831.1"/>
        <property type="gene ID" value="LOC119725498"/>
    </dbReference>
    <dbReference type="GeneID" id="119725498"/>
    <dbReference type="OMA" id="FKVRANC"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052970">
        <property type="entry name" value="Inner_ear_hair_cell_LOXHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901:SF3">
        <property type="entry name" value="LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45901">
        <property type="entry name" value="PROTEIN CBG12474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="175"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="39004" checksum="D619418172F0FEC3" modified="2023-02-22" version="1">MNSVSVWDAMASGSTAVARPIRTLDPRPPYAVDRPRPQSAPIRKPVSPPKPLWRDSRSDSIPHKQRRFTTSLRSSSANQDSYVSKRAPFAAKRLHALNVERQMMTGTYPRVENGRTVAAPEYDPFADPHLTDYFARKFSIGLPRPPSGAKRRPASANGRTSSTWNGGRHSAASECMYRVTVKTGDKKNCGTAANVFIQLKGSKGKTAKRKLSKKSAKTQSGFMKIKYSRNTSKVFKLKMQDVGELQTLTVEHDGLEKPDSWYLEEVEVTNLSSKQTWLFHCGQWLSLFETDCQLRRVLKALDPKKHGKTEYEVIIVAGDVKRADSDSSIYITLFGTWGTKYESGHGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQY1</accession>
    <name>A0A913ZQY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053496.1">
        <property type="nucleotide sequence ID" value="XM_038197568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197568.1">
        <property type="protein sequence ID" value="XP_038053496.1"/>
        <property type="gene ID" value="LOC119725948"/>
    </dbReference>
    <dbReference type="GeneID" id="119725948"/>
    <dbReference type="OMA" id="FYKQSVN"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036881792" description="CHAT domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="807"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125635" checksum="D14569356C703487" modified="2023-02-22" version="1">MTHDYMHAADVAFLILHLLLQPADECPMSSSASKLHIILCISLLAGIIKTHTFHIGKRDGSSNMAASSYTYIPKLSLKAAHRERIEELMVDVEKQQQRLLAEFRAENYETLSVDERISEAHNLLSTNLPATAALLKQTLTSPALTVKQQMLCYRLLYLVYMSLGPLSEGQEAAKQEYRVVKTVSLSQIGNRSSATGTGNVDPQVSTSSPEINEMRFQAALDLGNAHRFLGNMGDAKIHLDEAMAVAVAMDDTDKITTATIHHGEWILASGHLKDAISQVFQPLLKRNMSDRNRGILLQAFGNAARAAADWGPAKEYMREAIAIAERLNDPIAVADRQGDLGTIFRSEGRTSDALLYQKKQFVFASGRGDQAALCVSCFNIGFTHYSMKPPDYDIALIYHSIHLELAERIGYLAMKSRALNALGKIYTALRDYESAILLLEECLEVHSKIGNHRGLGIAYGNIGTVYRAMGKFDEAIVYHEKYRKNAAERDDVGGVAIMQRELAMDYLFKEDLDMAEQYITDAFFTLERIRAKIGAEDSSRIANFEKNQSEAFNLLQTILIRKGKYREALALSEQGRARALADLIQQNQEELEPGSPRDFNNDSAYLSTISMLEERFTERALSDIFQTASELNTTLVIYSIVTEFTPAGDVEKWLYSWVVARETTEPTNGEIRNVPPSDPTNRGGATVKDGDWKVHFAKGMLSSEKKTQEAILDDKHVNALCRSLAELSVKENIDVKEPDVCASKDQTECTEASTDHIEDSPARDIPHRLYRQEKLAHVYGGLEETKPKQPVTDPRLQRALDKLRVDYDIFIAPIESFLPEWREGMADVPRITFIPQDYMFNLPFCALLGPDNLHLIQKYVISFVPSVRTLKLTNQRLTQLRQTSTTAPPSVLAVGNPTMPHPKIPALPAATEEAKMVKKYFQSHSSLSSLEGEPGTDSMVLTGNDATVDNVRQKMTGHSVLHFATHAEQDNRIVKMIKEGTQDCQPERVPTGDFSMQGFLVLARSHENCSGLLMAEEVKDQRLKAEVAVLSCCQTGKGQVTGDGVLGLYRSFLVAGAASVVVTQWKIYDKATAQFMRHFYQDFIVHRDSARALREAMLSMLADRGEHHLPQHWAAFALIGASRLIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRN7</accession>
    <name>A0A913ZRN7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053751.1">
        <property type="nucleotide sequence ID" value="XM_038197823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197823.1">
        <property type="protein sequence ID" value="XP_038053751.1"/>
        <property type="gene ID" value="LOC119726215"/>
    </dbReference>
    <dbReference type="GeneID" id="119726215"/>
    <dbReference type="CTD" id="51031"/>
    <dbReference type="OMA" id="CDAECNG"/>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08358">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000014">
        <property type="entry name" value="glyoxalase domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059155">
        <property type="entry name" value="GLOD4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21207">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="297" mass="32683" checksum="DB649A55C242AF87" modified="2023-02-22" version="1">MSSRRALHFVFKVGDRTKTAEFYRDVLGMQFLRHEEFEEGCKATCNGPYDGKWSKSMVGYGAEDSHFVTELTYNYGIKEYRLGNDFQGITIQSNKAVQNARSKNWPLLPVSDGVYSVEAPGGYKFFLLDQPPPAGDPVKKVTVGVSNLAKSTDYWTKLCGMTLYEQTTNTALLGFGDSQCKLELKDAGGAIDRGTAYGRIAFACPRDQLPGIESSMKSADQTIVTPLISLDTPGKATVEVVILADPDGLEICFVGDEAFRELSQVDPKADQLLDEGIKADKSDEYFAKHPERKGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS16</accession>
    <name>A0A913ZS16_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Histone-arginine N-methyltransferase PRMT6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054563.1">
        <property type="nucleotide sequence ID" value="XM_038198635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198635.1">
        <property type="protein sequence ID" value="XP_038054563.1"/>
        <property type="gene ID" value="LOC119726785"/>
    </dbReference>
    <dbReference type="GeneID" id="119726785"/>
    <dbReference type="CTD" id="55170"/>
    <dbReference type="OMA" id="CIHVDYT"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000016">
        <property type="entry name" value="Protein arginine N-methyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF73">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="224"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="412" mass="46513" checksum="337756E7EEAE5ABF" modified="2023-02-22" version="1">MLHVFHTTVPHTLCMHSGPTDCSYFIALLVSQAEQIPESQHKQSHRTSHCSLSLHFLIMASNGSDEAPAKRIKRRRQDEDGFYFKSYAGVSIHEEMIRDEVRTNSYRLAILRSSEQIAGKIVADIGAGTGILSCFCAQAGAKKVYAIEASAIAEQARKVVKSNGMEQQIQVIQGKVEDVELPEKVDVIVSEWMGHFLLYESMLNSVIYARDKWLKKGGIILPSKASLYLAPITNEEIYKERIDFWSEVKSKYRLNMDCMIPYAKECIFGSVQIEDVIGSDLIAHEREVATIDISTITEQELQSIQGSFDFKCFGISKFCGFAAWFTVTFDDIQDRDPVTISTSPYKHPTHWKQSVLYLPEPVSVEQDTEMKGLITLSPGMTNSRYLDVALQYTVGEMPQISRHYTMSDDYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSU7</accession>
    <name>A0A913ZSU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054494.1">
        <property type="nucleotide sequence ID" value="XM_038198566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198566.1">
        <property type="protein sequence ID" value="XP_038054494.1"/>
        <property type="gene ID" value="LOC119726736"/>
    </dbReference>
    <dbReference type="GeneID" id="119726736"/>
    <dbReference type="CTD" id="4438"/>
    <dbReference type="OMA" id="KMTMLYK"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000013">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000003">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="900" mass="100565" checksum="5F4FA7FCDBF7CCF1" modified="2023-02-22" version="1">MCTGTGSAEQVSQESHFLMASSSSTSKGTNPRYAFELSDVTSNSGSSGPWRASYLRDAQTSSGPSTHVLTSVGTSRLNASSSKFSTPRTSTSVTGPTPGSRSSRQTSYRGYSISSNTPATGPQSSNLVAIVEGRGLAQGEIGMASIDLKQPELILSQFSDSQSYVKVTTKLQIYQPIEIVMPVTACEGSMTKLFKLITDNFHNTSIATVQRKYFNETKGLQYIKHLCVSDFITVEMEITSKYYCLAAAAALLKYVEFIQNVVYAPSSLKVVFRGSEQSTMIDATTARNLELVQNMKDPKSQHTLFGILNYTKTLAGARLLRANILQPPCALDTIMLRLDVVTELTKNEELFYNLQSVLTRFLDVDHLLSLCVQIPKQETVKTAEAKITNVIHLKHTLELVPPLMMALEGSKNKLLLAYFKSLGDERFNTMLEKIHTVINDGTRYQKGILNMRTQKCFAVKPNINGLLDVARRTYTEIVDDISDLISQLGEQYSLPLRTSYSSNRGFFIQLYCGNKNPISTDSMPPIFIKVVKSRNTISCTTADLIKLNDRIRESLNEIYLMTNIVVSELLNEIREHVGCLYKLAECVSTLDMLVAFAHTCTLSEYVRPEFTDTLAIKNGKHPILDKISYEPHVANNTYVNEESNFVIITGPNMSGKSTYLKQLALLQVMAQIGSFVPAECSFFRVCDQIFSRIGCDDDIETNASTFMLEMREINYIVQNCTNKSLIIIDELGRGTNSEEGIGICHAICEYLLSVKAFSIFATHFMEVANLDVLYPNVENYHFEVEHEGSTPRGNKRLAYTHVLSKGRTDEKHYGIKLAEISNLPESVVTDAKQMCETLSKQKRQQHAADHDDQDQRVVYRLARRLMQAARNSRLDEPSLRSYLANLKAHYLKELQAVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTD2</accession>
    <name>A0A913ZTD2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054862.1">
        <property type="nucleotide sequence ID" value="XM_038198934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198934.1">
        <property type="protein sequence ID" value="XP_038054862.1"/>
        <property type="gene ID" value="LOC119727041"/>
    </dbReference>
    <dbReference type="GeneID" id="119727041"/>
    <dbReference type="OMA" id="HIRRSEP"/>
    <dbReference type="OrthoDB" id="10566038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824156" evidence="3">
        <location>
            <begin position="32"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="44153" checksum="134D321FB430A5F5" modified="2023-02-22" version="1">MRQLAAELRPVITAGCVLVFLLLGGIPCTSGAGTVRSLPRVLNASLSEIRDYFCDSDMCRPGPACKLCRQDRDHDAYCEKPLEETSNGDCDWDQDLYCTYNDASVCVYDQDFSSSCMYYYTILGPLIYCVCDGSEVPRGLRCSDTTSAPTQQTRKPTTSSPPEATLPSSQTNVEAIIIGSVLSAVLLLVLLIIFWLCWTKKLTLLRRSQNAAGDAHDGTNSKDKDHPLKLQPRELGTNADQKPDSPGLLNPTYSTSLDLNQDHYYSKIRDEGGTPVEGRKRHAQDDHVRPSAPPIDTEAPADHHYFVLERDGEQVETDDQAGSPEEPNNHDYFVLEKDDSQHGNDYGENVNATDGATSRPRASADVSYDHIRRSEPGHSEDAPLSQVTGYDHIKRPGQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTN5</accession>
    <name>A0A913ZTN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054565.1">
        <property type="nucleotide sequence ID" value="XM_038198637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198637.1">
        <property type="protein sequence ID" value="XP_038054565.1"/>
        <property type="gene ID" value="LOC119726786"/>
    </dbReference>
    <dbReference type="GeneID" id="119726786"/>
    <dbReference type="OMA" id="VSPICKI"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="2">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="426" mass="46379" checksum="87EB0B59B7C9E980" modified="2023-02-22" version="1">MAEGCAVPTLAATDAGLSSRSRSGSSSGSSESDGSPICKISPLVAPVSSSPRPLTPKKRHRAEMEEEARRQEALRATEKEKAESEDKTLSADDKSKEEKELTVKVIPESETETPAEAEATSPSTTPVKSKDTEIEATPTEKDNKRRSTKKRKAEEDVKDPDAAETTPAKRRTTPKKKEVAKTPVPSKSPTKAPKTPSSATVTESGDEPPLPDGWKRMVTQRMQGESAGKFDVYIWSPSGKKFRSRPQLLAYLEKTGSPLSIEDFSFKPPRSKTSATPARIRKSSPVKEKKTTTPTKKKKKTAAVEKATPRKDRPKKNNVAKKSPGKQAAGKAKKGKQQRKVMKPPPDTGSKKASRAQQLQKLLVKINFQKPGDIREMSEEDSSEESSEDDFDPGTTEEAGPDVSDVSLTPSPPKSKKIRRHSSPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUL7</accession>
    <name>A0A913ZUL7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054945.1">
        <property type="nucleotide sequence ID" value="XM_038199017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUL7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199017.1">
        <property type="protein sequence ID" value="XP_038054945.1"/>
        <property type="gene ID" value="LOC119727154"/>
    </dbReference>
    <dbReference type="GeneID" id="119727154"/>
    <dbReference type="OMA" id="FLPEIVM"/>
    <dbReference type="OrthoDB" id="10328822at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="285" mass="33434" checksum="753A25FB9854B2F7" modified="2023-02-22" version="1">MQMPQMLAYPQRSSPRKKSTKWHGALPVSAIEKVLAQENRFADSLLTERLKRIHTDRYRAQRLLDWQEQSFVLRQAIKETELREMGIAHTSFLPEIVMKMTEPDVRARRPFGRAHRSVTEVDLKANKIGKPQASLNELQTRESRWTATTARSDPFLEETFNKNIFTRLHGIDLPLYGPQADAKRESREQEFVHHLQRQQTKTKVTLDPRFRKLEQSLIRDETNLLVRHPKEQNEHVVTDEDKIEDKLIQNDRRVATKSATVIHKVQTELSQKPKSVFARSVWIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVI2</accession>
    <name>A0A913ZVI2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055081.1">
        <property type="nucleotide sequence ID" value="XM_038199153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVI2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199153.1">
        <property type="protein sequence ID" value="XP_038055081.1"/>
        <property type="gene ID" value="LOC119727301"/>
    </dbReference>
    <dbReference type="GeneID" id="119727301"/>
    <dbReference type="OMA" id="MKWTHIA"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="21">
        <location>
            <begin position="102"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="509" mass="56430" checksum="7540EF14FC73D7DA" modified="2023-02-22" version="1">MSYDPIPGLGAPVARIRHFVGGLLPRGKQDEEHLHFAKCDSTELSVLGPGEGDQAQLDGGAENGKPPVVNGGVSAAGNPLASAGQTGRSYGEASNVNIAKKQISTWDAGWNVTNAIQGMFLVALPYAVLHGGYWGLLALISAAIVTCYTGKILVECLYVTDDVTGLRMRVRESYVDIAKEVWGDRFAAQIVHSAQFIELIMTCILYLVLCGDLLSNSFPTNKLDETTWTMLATFFVVPCAFLRDLKAVSRLSFGNAIVHVIVNLILIGFCLSYAAHWHWGDVAVHVDIHYFPVSMGIVIFSYTSHIFLPSLEGGMVERSKFNKMLYWTHALAGLFKALFAYLCFLTFGPGTRDIITDNLPTQGFRAVVNVVLVIKALLSYPLPFYAAIELLERAFFSGRPRTFFPSCYALDGYLNSWSVALRTLVVIFTMLLAIFIPHFNLLMGLIGSFTGTMLSFVWPCWFHLKIKWHEIPWYQKLLNIFIILSGMIVGLIGIIYSMEALIKIYHEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVL8</accession>
    <name>A0A913ZVL8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055116.1">
        <property type="nucleotide sequence ID" value="XM_038199188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199188.1">
        <property type="protein sequence ID" value="XP_038055116.1"/>
        <property type="gene ID" value="LOC119727335"/>
    </dbReference>
    <dbReference type="GeneID" id="119727335"/>
    <dbReference type="OMA" id="HHIPEAY"/>
    <dbReference type="OrthoDB" id="1293503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF28">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="382" mass="42083" checksum="146E7081D199CA64" modified="2023-02-22" version="1">MMLYTGASTVARTGAGDSRSFEVKVGVHQGSVLSPLLFATVMDVVSSETRGGLPWELLYADDLVLIAETREQLHAKMAAWRVCLASKVLKINAGKTKVIVSRVSGGPMTSSGAWPCGVCGKGVAANSIQCTTCRKWVHRRCSGLKGSLQAASATFVCKRCRGDGLRPEEREAGLEVCGDTYEVVESFCYLGDMLGAEGGADAAVTSRVRSGWKKFRELAPFLTSKAPPLKMKGQVYTACVRSSMVYGCETWPTRVGHIQQMERAEMRMIRWMCGVSLADRLSSEELRRRVGVEGIGIVLRRHRLRWFGHVERKEDVNWVKRCTNVIVGGSTPVGQPRKTWQSSVSDDMRLLGVNARDVTDRAKWRRAIGRKQANPEQTGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVR9</accession>
    <name>A0A913ZVR9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038055763.1">
        <property type="nucleotide sequence ID" value="XM_038199835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199835.1">
        <property type="protein sequence ID" value="XP_038055763.1"/>
        <property type="gene ID" value="LOC119727776"/>
    </dbReference>
    <dbReference type="GeneID" id="119727776"/>
    <dbReference type="CTD" id="145482"/>
    <dbReference type="OMA" id="EEKCRYA"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF5">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="355" mass="38842" checksum="7B27017940B29A6A" modified="2023-02-22" version="1">MATSSNKRVCLASRPGANGIPSVENFRMEDCPMPELEDGQILVKLLCLSVDPYMRCRMNMDTGTDYMSPWKLDTTIDGGGVGVVVKSRSMGHSKGDVIEGFHLPWQLYVALDVQGFNCLIVNKVDVALVKKHWSLMLGLYGVSGISAYLGIKEKGHVVPDGDQTFVASAAAGSCGSLAGQIARLEGCTNVVGICGSEEKCRYLTEELGFNHAINYKTEDVGERLRECCPKGVQVYFDNVGGSVSDAVIQQMTPDSHVILCGQISVYNTDLPYPPPIPEETQQALTEHNITRERFLVLNYIDQFPDAIEQLCVWYNKGEIKYKETVAEGLENAPFAFVSMMTGGNIGKQIVHVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW40</accession>
    <name>A0A913ZW40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055515.1">
        <property type="nucleotide sequence ID" value="XM_038199587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199587.1">
        <property type="protein sequence ID" value="XP_038055515.1"/>
        <property type="gene ID" value="LOC119727625"/>
    </dbReference>
    <dbReference type="GeneID" id="119727625"/>
    <dbReference type="OMA" id="YKMCGRS"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF908">
        <property type="entry name" value="DEUBIQUITINATING APOPTOTIC INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="439"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129798" checksum="E592F0E5A7422EDB" modified="2023-02-22" version="1">MDKILLGIAASTHSEAVKRAIIERVINSAGKGHPEDLVKAILDISSHWITDNDSEFLQQIGRQLFHAWAKHNQTIFEEFFNHQFLVRILGLEILHPERMVHFVHDGLKMLQNRATAVKIVQMQVVALVKKHRDLVTLVEVSHLLLAFPDCLPKGTAAGLLCISAVENVGALEVAPSEATMKANLEGMIHISALLHHIWHDNMVTVLPSLAAVFNLISTLPSSDRPSPSVALGALVQHVPVELIATITKNAASDMSIVDERMTTALTRMIEWLSWPRVQNIDRWIVSFLKNLALAQKFTILINVTLASVKKVFVKLCFPIVRDSALPVLTHMQLSFQHSPEAFHKIVAHVPELMKRLKTENSASSQDCTQKVAELMYCLMYHHAGYPDLYEPVLDALKDIPRPSEEAMKETLKLSAWTSRAPVNSAFATRFLPRSETGKTGLVNLGNTCYMNSVLQALFMTSGFHEAIMACPVYNDQCVVARLQTVFAFLTHTQRAAYSPREFLIASRPPWFSPGTQQDCSEFLKYLLDRLDEEEKSIRKFEAGLQRTREWVEHMKRKNAKKMEEEAGRMSSEEGEVGRRRIGGETDMEGCGRLGVESSTEMDTSSNEIATKEEASKIEMEDKTEKRKMIPERGEKQPKGCDEVVMETSVSSPTIDASTISLSPCIISEQGHSVCTPKPEDNSAATKLVAVKLSGIQSDQASGDTKIKFLDRNTTSEPPIGPSIVEEYFSGKSVTRIRCLTCNSVSSRTEAFFDLPLAFPGSDTTSSMRGGESCTNKDDASKSLGLAADRLAQEELASGSKQWELNGGAAASTSAIKDLMSGPGQSGEGSNSSTAPPSSLEELLVHYLNPELLTGDNQYHCEKCRCLRDAEKRIEISKAPKVLMLTLMRFSYDVKTQSRCKILADVRFPKILNLVLNHPERDNGDKANTEADKVSDEQDLSQDPPCSKRLRQNSENLTTSNDEETKHRFALYGVIVHSGLSSESGHYYCYARHSNFSPDSQRKSKPSKIKTECESGDSKMQDLLPEDVEEDLLPDQWFLFNDSRVSFSSYDSFGNVTKRFPKDTAYVLFYRQVPEESNEQSGCQTGSDTSPVELREKPLKKNLQERVKKDNAQYLKERELEARTMALRTSQGLENFSSNRRDFDDRNDPPSGCGGGGGMEPPRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWI1</accession>
    <name>A0A913ZWI1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055421.1">
        <property type="nucleotide sequence ID" value="XM_038199493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199493.1">
        <property type="protein sequence ID" value="XP_038055421.1"/>
        <property type="gene ID" value="LOC119727567"/>
    </dbReference>
    <dbReference type="GeneID" id="119727567"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="142" mass="16372" checksum="488E368F2723713A" modified="2023-02-22" version="1">MLRPAVSGGSVSCNVTLVRMAKKTDKKKARSALNEVVTREYTIHLHKRIHGISFKRRAPRAIKEIRKFAVKMMGTEDVRVDTRLNKHIWSRGVRSVPFRVRVRLARKRNEDEDSPHKLYTLVTHVDVPTFKGLQTVNVDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWU5</accession>
    <name>A0A913ZWU5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="6">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055984.1">
        <property type="nucleotide sequence ID" value="XM_038200056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWU5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200056.1">
        <property type="protein sequence ID" value="XP_038055984.1"/>
        <property type="gene ID" value="LOC119727972"/>
    </dbReference>
    <dbReference type="GeneID" id="119727972"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000461">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="788"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127870" checksum="71C04DED3F1ECEB5" modified="2023-02-22" version="1">MASRFFATGSSSESESSSSDNEEPVPSKVITQQRFALSDSEEEVKRVVRSAKSKRHEEIMDVIKQIKNQKKIRDVSRVLSSFDDLTRVYQKSQKVLNPDGGHPPRFYIRTLVEMEEFVNECWEDKKKLTKMNAKSLSTLRQKLRKYCRDYEEPINEYKENPDVEREQEEEEDEEISGDEMDSGDEDGLGVTGTKRTPSKIKDEESDSDSSFWDESTESESDSSDAEAGGYGGLTAAYFLKSNNPEKEDRQQNVRLHRRKEREARRAKQEEEEEGDEEWTKVTKGLPISKVMFDKGTDITHTLVVKKLHEIVSARGRKGTNRKEQIELLRELRTISAQNNLGVAIDLKVLFNITAAIYDYNPNVATCMKPDMWIKCMDSITEMLELLKKNPDITINENIPEDAETYNEKPYRIRGCVLTIVERMDKEFTKILQSADAHSTEFVERLKDETRVTKIITTLQAYLEERGSASDLCRIYMRYINHIYYKYDYDKLQQLEEQVQERRAKILRESQEGTGKDPDTTGDNKTETGEGTTDSKGEEKGSIEEKEGSKEESKEESKEESKEESKEESKEESKEESKEESKEESKEESKEESKEESKEESKVESKEESKEDESKEDATTEDGSKEDASKEDVVEGEGEGSEKKKEEVSKKTKGDGSETTAELMDRMCKFIYSKDTTDLIRTRAMLCHIYHHALHDRWYMARDLILMSHLQSNIQHSDIPTQILYNRTMVQLGLCAFRHGNIKDAHHALLDIQSGGRAKELLAQGLLMQRQQERDPTQEKIEKSRQLPFHMHINLELLECVYLVSAMLLEIPYMASHNFDIRRRMISKSFHHQLRLSERQTLVGPPESMREHVVAASRAMRYGNWRACKDYLLNDKMNGKVWNLFPNSDHVRELITRKIQEESLRTYLFTYGSVYDSLSMNTLAEMFELEKPVVHSIISKMIINEELMASWDEPAQTVVMHRCEPTKLQNLALRLADKVNNLVENGERLLEYRQNDGRGFNKGGGQQFRDKQGNYRGDRSDRGGERSGYRSGRGGYRGGGGGGNYRGGGGYRGDRSGGGGYRGDRSGGGGYRGDRSGGGGYRGDRSGGGGYRGDRSGGGGYRGDRSGGGYRGGRRSNQNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXG4</accession>
    <name>A0A913ZXG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pachytene checkpoint protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056236.1">
        <property type="nucleotide sequence ID" value="XM_038200308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056237.1">
        <property type="nucleotide sequence ID" value="XM_038200309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200308.1">
        <property type="protein sequence ID" value="XP_038056236.1"/>
        <property type="gene ID" value="LOC119728184"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200309.1">
        <property type="protein sequence ID" value="XP_038056237.1"/>
        <property type="gene ID" value="LOC119728184"/>
    </dbReference>
    <dbReference type="GeneID" id="119728184"/>
    <dbReference type="CTD" id="9319"/>
    <dbReference type="OMA" id="NVCDSVQ"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19508">
        <property type="entry name" value="RecA-like_Pch2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000662">
        <property type="entry name" value="Pachytene checkpoint protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="179"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="49503" checksum="7F1E054C589AB2AF" modified="2023-02-22" version="1">MNCHVVLHKLKDMYRVTDLEDALPVTPAKSVHVEVCQNPCSTVHRESIKDHVTKLLHRQRVSYGDMNLTEFDDPYLKEHVKWIAICDTELDGSGKQAIDLCQSELHLHVFQLSNEEPGMEELEGEEMAAASHWLLPAADFEGIWDSLVFDTHIKSHLLHYATTTLLFSDCKVDPNIISWNRVVLLHGPPGTGKTSLCKALAQKLCIRLSDRYTYGQLIEINSHSLFSKWFSESGKLVMKMFQKIQELIDDTDALVCVLIDEVESLTAARKSSLNGTEPSDAIRVVNALLTQIDQIKRHPNVLILTTSNVTEAIDLAFVDRADIKQYIGPPSASACFKIYHSCINELMRARIISPAQQLLDLRALEVMRFIENDATKLSLKLKEIACKSEGLSGRTLRKLPFLAHALYVKANPVSLEDYLNALSDAVDKQFKERQQLKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXR4</accession>
    <name>A0A913ZXR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056438.1">
        <property type="nucleotide sequence ID" value="XM_038200510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200510.1">
        <property type="protein sequence ID" value="XP_038056438.1"/>
        <property type="gene ID" value="LOC119728316"/>
    </dbReference>
    <dbReference type="GeneID" id="119728316"/>
    <dbReference type="OMA" id="VIEWDYW"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038100982" description="Triacylglycerol lipase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="10">
        <location>
            <begin position="364"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55108" checksum="0FDF80ADF75374DC" modified="2023-02-22" version="1">MRTLVVVLGALLPLVFGASEVCYPNIGCFDYGYPFLDPPDRPLSWAPQSPSKINPRFLLHTRRNPLKAEAQTLDSDDPSTISNSHFDSTKETKFICHGFIESGVIEWDYWMTDMVQEFLNYDDYNVIRVAWGSGSLFPYTQAMANTRVVGAETSRLIDTIRGMYGISAASFHFIGHSLGSQIGGYVGKRQPGLGRITGLDPAGPGFENTEPEVRLDPTDAIFVDTIHTDAQHTLDLGFGMIQPVGHMDFYPNSGRDQPGCDQTIFEDFIDEGLIGGAVKFVACNHMRAHEFFSDSINKCPIYGFKCPNAADTYDNFVNGECFNGDVAMMGFHSINNKPASGVIHQTYYATTTDKSPYCLDNPFQIRLYFEDPWFSETFKGWAFVTLTGGKGSTSRTKLHENSLNFKPGTERNFIFTTDTDPGDLTQLEFYWDHDFEFLNPGDWPIFDDVEVFIAKIEIKGLRWQKSYTLCNRKPSTGINSNTKAYFDVSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZT7</accession>
    <name>A0A913ZZT7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056964.1">
        <property type="nucleotide sequence ID" value="XM_038201036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZT7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201036.1">
        <property type="protein sequence ID" value="XP_038056964.1"/>
        <property type="gene ID" value="LOC119728704"/>
    </dbReference>
    <dbReference type="GeneID" id="119728704"/>
    <dbReference type="CTD" id="152503"/>
    <dbReference type="OMA" id="VHKSCMK"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF48">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="832"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="901"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1240" mass="130367" checksum="C4C686B6E40499F8" modified="2023-02-22" version="1">MDGVESAETSSTSGNPVPSKRPTIIRAFPRSGTTNNDEDNNQSSNSSTVDSVQQPADNSDTVIKKTPPARPSTGPSREASFEAPARPASVHLRSSELKSAPRPASVHLRNSELKSAPRPASVHLPLSQAPTVKDKPAAGKPQRKRPEITIVSARPLSEVAGFSKDTFSPSGKPTPTAAAKPTVGTPADKATTAATEAPSNVPSSHPVAAPRRGLDKDISKTTAPVDDRKIQPPGVTGGTDMSGAPPPLPTNRPKGPYIPPPLPSTRPKGSYVHPGSGPSSSVTEEKASSEATPVPKPQPRSVLADTEETPKGHAAPSRPPQPVTHNHVSDESSKLPTPRNRGLVDSEKPVFVLPPAPSSELEGASKPHITLKPPVSVEQPSQAPVVHSKTQETPQLPPKPADKPALTDPVTAPKPAEKPPLPHPVAPPKPTQQTGNTSAIAASASSDSHKPSQGPVPSKPTMPLMPHASGQKYSRTDILSLFDSTYQKNSKPESSSDAQKKVAGAVARNVSTEDALKFGSTAATVAASDKTRSGNEVSALHFASAAAQNTTKQDVNNISGGVNVLRQSEDGQKAASSFGRIAKSTASDVRSADSSSGDLKWQVASSAAKNVTADDAKNIGKAGVTLAKSEQGRKAASSIFNITRASMNQVNQTQSQNPPAPSPTARARPKNTGQQSGSSFGSLMGLMPPPKPQAVAKPSTTSVNKPAPVPKFKISAEPTAAGAQRFKPTIIRPGAEKPGSKPNSRNNSPEPKRKVPPPRPASGPQGKSKGSAPQRPNAPSGQPKSSTSSANLKPKRRAPLKPGGAPPRKSSQSESLPPRPGPGHLLYNKYMVSEPHGIALYDYKPIQPDELGFKANDVIVLLKRIDADWLRGRCGDAEGLLPAAFLKIVKDIPQTGNKPSTSEPCAVAVYSFEGAALDELRFKEGDNIVLLDRVGDQWYRGQCKGRTGIFPANHVKVIEDLPVKSLTVGSSNISGPRCTAKFDYDSTNPEDLTFKAGDVIKLVEDMGSQWLKGRLGSKTGIFPESFVDITEALPAKTSSTVMNGNSGNVVKAMFDFSAAESNEISFKAGDKITILSQVSSDWLHGELGSGLRGNLPSTFVDHIPANLPSFTADSPSEIGECIAKFDFEPAGEGELALKMGDRVTLLEYVGEDWLRGRIGSKEGIFPKTFADIVGKGGPSSGGPSLGTCKAVYDFHAEEADELNITSGDVIEILEYVSADWINGRLKGKTGKFPKAFVDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A088</accession>
    <name>A0A914A088_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ motif and ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057005.1">
        <property type="nucleotide sequence ID" value="XM_038201077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A088"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201077.1">
        <property type="protein sequence ID" value="XP_038057005.1"/>
        <property type="gene ID" value="LOC119728730"/>
    </dbReference>
    <dbReference type="GeneID" id="119728730"/>
    <dbReference type="CTD" id="642574"/>
    <dbReference type="OMA" id="SEHDRCQ"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65477" checksum="3C0D015238718D46" modified="2023-02-22" version="1">MPPKKPAAKPAGKPAASKSTTKSTPAKKVTPVKAGAKTPNRPGGKAASTPKAGAKKDNAPSKPKPPSKETLAAVVIQKWVRRFLGKGHLMKLRREKEEYEAMMEKLEKEAFVAMVKREQERAEEEHRKEMEERQRRKLRQQRIKRFLEAAFDGENDEILMVLKEVENDDVKQGIGTDPMGLALRAKHQLEMIDCEDANSNTPLSEAASGGHADTIKLLIERGADVNSRGQFERTPLYRAAFAGHLTAAQVLLQNGADPRLYASDGATPEQVAAHEPLTVLLQEWDITLTDTMITKMETQREQRKEEERKRREAEMAKLENQLAEAQKDHDTRQLQLNKAYCELNKRITEHDKCTAQNVKTDITLQVVKDAEHDLEIAKLEAEKTRERLANVKLQIREQQKTARGLEGEPEVGVKANIKELHDVLMRDVGDKIKNDGRWPLIIDPSGRASTFLRYQDINLINALNPNHMQPEVIRMAVLGAIRYGKPLVLDMLEVDMFETCTERFDEVHPGFMEDIMSKELIKNEKYVYLIKDSDGPEYSKNNFNDHRTKHFLFVIVTKIEPLDSLLERAYPIRIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A206</accession>
    <name>A0A914A206_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057391.1">
        <property type="nucleotide sequence ID" value="XM_038201463.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201463.1">
        <property type="protein sequence ID" value="XP_038057391.1"/>
        <property type="gene ID" value="LOC119728986"/>
    </dbReference>
    <dbReference type="GeneID" id="119728986"/>
    <dbReference type="OMA" id="CMGCGVT"/>
    <dbReference type="OrthoDB" id="5987960at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1480" mass="168509" checksum="951FBF781F681AE0" modified="2023-02-22" version="1">MGCARSSDHQVRECNDKKVCRICAGAHLTCLHRNFQQRRPEETASSHPQSATASKQPADKVPTNSSPPKEVIAVHPKRDEGMSNCIQVCSQPDQEGEGDHSMIIPVLVRSESDPAREFLEYAILDEQSNSCFVSKSLCERMNLQGPETQLLLSTMQEQNVQITSSRISGLEVLDVNREHTVKLPVCFKRDSVPAKKSQIPKPAVVHQWPHLKSLGEKLMPYDPTLQISLLIGSNCPRVVRPREIIAGGEDDPYGQRSLLGWGVIGNVCKAARQTDDQPAVCNKVVAAEPQRYQHFVYGTRVKEVLNPEKVLKVLESDFVENHQRKPYSVEDEKFLSVMEKGIKKASDGHYEMPLPLKSDAATLPNNRQLAVKRWNQLSARFRKNVKFREDYREFMKDVIPKCAEKVPLDQLEVDAGKVNYVPHTGVYHPKKPDKIRVVFDCSAKYGGVSLNDHLLQGPDLTNGLLGVLCRFRKEEVAFMVDVKSMFHQFYVEEKYRDLLRFLWWENGDPEKPVVEYRMKVHVFGAASSPGCANFGLKRAADDGEDEFGAEAANFIRNDFYVDDGLKSLPTVERASLLIKASQNLCGKAGLKLHKIISNKRELLEKFPAEERASGTRELDLKVDVLPMERALGVTWCVESDTFQFHIELKDRPFTRRGILSTVSSIYDPNGYVAPVTLRGKRILQQMCRDKLDWDSPVPEMLQPEWEKWRLEVLGLEKIQIQRCFKPKDFGTVTAVELHHFSDASQDGYGQCSYLRLVDENNKAHCSFVVGKSRVAPLKLVTIPRLELAAATVSATVSEFLRRELCYEMLHEYYWTDSKIVLGYINNEARRFHVYVANRVQQIRSLTNPERWMYVDTKENPADEASRGLTAKELVEKSCWLSGPDFLQKDGPFQPQPAVVAPLSESDPDVKKVSAFVTTAENNARHHHFEVSRLDCFSSWNRACRAVALCLRLKTKLRNRVVKKPCEGKVCSTPAKQAITVAELQNGEMEIIKNVQHEHFSVELQALQELGVIGQVTDGKTARVRNDYLKKTSCLYRLDPFLDVDGIIRVGGRIARSDLPIEAKHPAVLPYKGHVTQLLIRHIHEKVNHMGRGMTHNELRQRGYWVIGGSSAVSNYISRCVTCRKLRGSLQRQKMSDLPVDRLEPAPPFSYCAVDYFGPFLVKERRSQVKRYGVLFTCMASRGVHLETANSLTASSFINALTRFQSRRGPVRQLRSDQGTTFIGARSELREALAEMEQDRVHQYLLESNCDWIPFKLNTPHASHMGGVWERQIGTVRRALEGLLLKTTTQLDDECFRTFMTEVEGIINSRPLTTDYLCSSDAPEPLTPNHLFTMKPKVVLPPPGKFQKEDVYARKWWRRVQFLTNEFWVRWRKEFLHHLQERKKWVNPVRDLQVGDVVISKEGEQTRNQWPLGRVVETYPSNDGRVRSVKLLMADGTRDNLGRRQHSPSLLDRPVHKLVLLVPAEKPEAQETREVPTEEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A270</accession>
    <name>A0A914A270_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057456.1">
        <property type="nucleotide sequence ID" value="XM_038201528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A270"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201528.1">
        <property type="protein sequence ID" value="XP_038057456.1"/>
        <property type="gene ID" value="LOC119729035"/>
    </dbReference>
    <dbReference type="GeneID" id="119729035"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="OrthoDB" id="10266268at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="13">
        <location>
            <begin position="52"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="330" mass="37108" checksum="95BF4C6485F2FE56" modified="2023-02-22" version="1">MDSGMAQKTWEISNSIETIQSVDEIYKFDKKQQQEILSAKPWTKDNHYFKYIKISALALLKMVMHARSGGNLEVMGLLIGKVDGETMIVMDCFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVGTQMLNQQFQEPFVAIVIDPVRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYSLDVSYFKSALDRKLLDSLWNKYWVNTLSSSSLITNSDYTTGQVGDLSEKLEQAEAQLGRGSFMVAMDHEKKAEDKLAKANKDSCKTTIEVIHGLTSQVIKNRLFNQVNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2B4</accession>
    <name>A0A914A2B4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ENPP1-3/EXOG-like endonuclease/phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057759.1">
        <property type="nucleotide sequence ID" value="XM_038201831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201831.1">
        <property type="protein sequence ID" value="XP_038057759.1"/>
        <property type="gene ID" value="LOC119729243"/>
    </dbReference>
    <dbReference type="GeneID" id="119729243"/>
    <dbReference type="OMA" id="WIGREGD"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="757"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112935" checksum="287ECD293078FDFE" modified="2023-02-22" version="1">MSGSIYHYSDSDYEMVDPLQESLSRTPESGNSRTVAPEPTQRTPVGSSPQKPPRPASMAGAQPRNHSGEQSRSSSIQMDDIHITDPRYSEVPEPYETISIKSQPADPNFNEPQVQPTNKASPNQYTPTEPSFIQPEDRPSTKSSSDRYQPPQTKTTQSQPPANNSPRSEPINKEERKKAVLVNKLKAADEPDDDYDDYENSFMQRHRRPIMVVVFLLLVALAIALGIGARNASMVTFEGSFSKNIGKQCTHLCKDVNRYSTPPLVVIALNGFQSGFFRHQSLVSNMARLAECGVHGNTIPSYPSTAIPNLYSVVTGIHPAYHGKASDWLRAYSLNETEFGPAEHPNTYSRMDPKWFQLNGLWGIAADQGLLTASHSWIGREGDIDEERPPSPSYYQTYDSGVDYRNRIQTVLNWLNLDPSERPDFITVYFEDPGVTVQKYGLDSEQTMNSLARVDAAIGKLLDAMYEESNLGCINVMVVSTGGLAERSCDRTYYLIDDLRDVDDFTLLPDSVTSVGSITATDRAPSEMDTSEEIMEHLQCKVDHGQVFTKRLLPVHLHSSYGLQYEDTVVLMDEGWTFAKQQEGYDRSNCKGASDGFNPYSSNMQGMFVGFGKSFKTAKTVPAVRNVDLYNLMAELINVTPRDNNGTAGILSDVLTSPTTQDTVVMEFSSPRNADCSYPANDNEYDQRQRDSATGCVCTQATLDSYPETNGVVLKDKDENIRQTNAASSRQRNAPFGFPKISRNVGPTGQDYCELYQYNFITAYENRLEIPLFATFTMQRNAGRVTQIINCLRYDVRLQPEKSPKCSNYDSNMNPRLPIDVVQGLLYDPSLADSVDNELNALTSANIVPMYTAFQQDVWLPLAGKIRQWANHDNRSAEMNVVIGPVYDWDSDTLQDTYRDLAASQAWVVDTPVPSHYFIVASRCKEDVSLNMCPLQSLEVISFVVPHTNSVRICKTFDDYLSTHLTSLQDVELISGLQLFPDMSTNEELKMEYLRFKTKMPTMSPWMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2G1</accession>
    <name>A0A914A2G1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057835.1">
        <property type="nucleotide sequence ID" value="XM_038201907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201907.1">
        <property type="protein sequence ID" value="XP_038057835.1"/>
        <property type="gene ID" value="LOC119729295"/>
    </dbReference>
    <dbReference type="GeneID" id="119729295"/>
    <dbReference type="OMA" id="ENRRDCY"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037181370" evidence="13">
        <location>
            <begin position="40"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="16">
        <location>
            <begin position="153"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="250"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="90"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="545" mass="58843" checksum="3C772F71763EC4D0" modified="2023-02-22" version="1">MMMLPKDGIATLRCPCSRGVMRISQMVFVLCGLLARVGCQPYEITEIRLMDGPPDAPNSGRVEVLHESTGDWLNVCDVNYWGDNDGTVACRQLGFPGFSRARRTSYYGEGTNNGSVGGIGCSGDEDSLGQCTHQPVKETEGCNGRVAGLICTVPGFLGCFTDDRNNRVFSEMRLTAANMTISLCLDRCRRQGARYAGLENRRDCYCGAEGTQIDIYGRLRDRDCKSDCLGNPDEICGGGGKLSIYDLTLGYCMDPGTPANGGRRPADGDAFHYGVNVTFFCDDGFELVGSDSARCVLGDSPQEVRWDEPMPQCRSLSVSTTPDPGLVDDMLSSGQGAGTTAGIVVACVVVFVLVAILVILFIRKRRRTLDRNANRTPGDKHGNAYSEPDPASRYQTSPGTTSANSEYQDLTLPSNDAEGPYTSLRKPAQHRTSEKEIPEYLELYAEGINPLKEQQGGKPPKLALASGAGAGKMPAAARQKASRTGKARLPSPEVHENEYSYVDASRFSSNSQGLGAGKPQDARPQQSQEYAEADSVYYSVPPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3G8</accession>
    <name>A0A914A3G8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058376.1">
        <property type="nucleotide sequence ID" value="XM_038202448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058377.1">
        <property type="nucleotide sequence ID" value="XM_038202449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058378.1">
        <property type="nucleotide sequence ID" value="XM_038202450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3G8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202448.1">
        <property type="protein sequence ID" value="XP_038058376.1"/>
        <property type="gene ID" value="LOC119729734"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202449.1">
        <property type="protein sequence ID" value="XP_038058377.1"/>
        <property type="gene ID" value="LOC119729734"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202450.1">
        <property type="protein sequence ID" value="XP_038058378.1"/>
        <property type="gene ID" value="LOC119729734"/>
    </dbReference>
    <dbReference type="GeneID" id="119729734"/>
    <dbReference type="OMA" id="XNLLPTT"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09537">
        <property type="entry name" value="SAM_CP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF21">
        <property type="entry name" value="GEMINI, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="9">
        <location>
            <begin position="45"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="510" mass="57346" checksum="C9909BAD53F5C6D0" modified="2023-02-22" version="1">MSWRLQLDGGLAADFDSNLSGLGTELGTAAYNMSEVLALPIFKQENVEDAFQYILNAATSPATKVNEETLTYLNQGKSYEMRLKKLGDVSQFEGKLLKSVVRVLFNDKRLQYAESEQLASWRTNRPGERLIKLDVPLSHNLIEFNASSSALNAVEFLWDPTQIASCFVQVNCISTEFTPKKHGGEKGVVFRLHVDTHIHGKEQEKPFHSASCQVKVFKPKGADRKHKTDRDKMDKISDSEKEKYHPSYECTVLTEQEIHLSGSESNGKVPPSPSELDWSLGQSPLMHKHVSPFRLPTENIPVPLQLREQSPIFHPDDSFGSFEDSANNQSSSSETVEHLGAGNFVGTPSVGTSIQDTQDWLKQNRFGTYTKLFQNFAGADLLRLGKQDLIQIMGPADGIRLNNALQKRHVRPRLTLYVCQEQEQVYHAVYLELQTLQELRAKLATLYHIPSEHISTILRQGPTGIRVLVSDEMVQNFQEECLFSLQTIKDEPSSGLDKHVQGETYTIIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3Q8</accession>
    <name>A0A914A3Q8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058011.1">
        <property type="nucleotide sequence ID" value="XM_038202083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3Q8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202083.1">
        <property type="protein sequence ID" value="XP_038058011.1"/>
        <property type="gene ID" value="LOC119729504"/>
    </dbReference>
    <dbReference type="GeneID" id="119729504"/>
    <dbReference type="OMA" id="YLHITIV"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="323" mass="35247" checksum="93F19680DAB3D661" modified="2023-02-22" version="1">MGAAITLQVVQNCAGVIGVLGNTLVCIVICRVQSMHTLTNGLILNQAAIDLLGSLVTLISANVGKLDPVPDGPTGELYCRLWFSKFLNWAFFAASTFSLTALTLERYLAILFPFTYQTRFTRRAAILVVIAVWLTGCACSAYNIAIKRFNGIGSCESVNVGGSQLVGVLLFCFEYLIPVTVMLYAYIHIIVVLKRKARRVGVMGGNGTGSSAERQAAGRGEGQAESLVRARKNVLKTLFIVFCSFVVCWTPNKIIFFMFNFGWPLDFQGALYVISVALVVSNSAVNPIIYALKYRQFRHGVLYMFGVRSNADEVVLGMSSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4P4</accession>
    <name>A0A914A4P4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058817.1">
        <property type="nucleotide sequence ID" value="XM_038202889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4P4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202889.1">
        <property type="protein sequence ID" value="XP_038058817.1"/>
        <property type="gene ID" value="LOC119730106"/>
    </dbReference>
    <dbReference type="GeneID" id="119730106"/>
    <dbReference type="OMA" id="NIWETSW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="343" mass="38286" checksum="74CA41F869D76C68" modified="2023-02-22" version="1">MELITAIIIIIATLAVLYFRHYKKHIASRRYCRSNASLEGKTVVITGANSGIGKVTALDLARRGARVILACRNLQKAEDAAKEIKTRTGNSEVVVRHLDLARLQSVREFARKINEEEKKLDILINNAGIPEFGHEGDVTKDNFHAVFGTNHFGHFLLTNLLLDLLKKSAPSRVVTVSSNAHERVRSSLDLSRAVDARRPGRTDGAAPVLYPHLRDYAQSKLANILFSRELARRLESTGVTSVSLHPGVVFSSWWLNMKVNSVRTLVYYINCPIMWLTFIDEEAGAQTTLHCALDESVSQLPGRYFANCAAEQPSELARDDEMARRLWDVSCQATALEETTNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8K5</accession>
    <name>A0A914A8K5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060097.1">
        <property type="nucleotide sequence ID" value="XM_038204169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060098.1">
        <property type="nucleotide sequence ID" value="XM_038204170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204169.1">
        <property type="protein sequence ID" value="XP_038060097.1"/>
        <property type="gene ID" value="LOC119731141"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204170.1">
        <property type="protein sequence ID" value="XP_038060098.1"/>
        <property type="gene ID" value="LOC119731141"/>
    </dbReference>
    <dbReference type="GeneID" id="119731141"/>
    <dbReference type="OMA" id="ICCRARF"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF9">
        <property type="entry name" value="X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="280"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="596" mass="64959" checksum="E3E43CDB5ADB64E3" modified="2023-02-22" version="1">MFMYCWGAKCHGQLGLDDRTAGTSDTDTDEPDSNKGDLVSTPLEVRFFRRRDVCAVACGLRHSVFLLKDGTVYTCGSNDKGQLGHEMHGRIPGQVKALETCVIRHVACGEAFTVVTAENGTVLSWGDDSCGQCGCGSEDREPKRTPRFLKRLSMHHVVQVACGGAHCVALTKGGRLFVWGDNTYGQLGLGHTSVKYVEKPTEITSLHGLPVMRVAGGGAHTFVVSVSGTVFGWGRNHCGQLGVSDTKDRSQPTLLKSLRTQKVKFIACGKNHTAALTADGGVFTFGAAADRQLGHSSSSNEINPRKVFELMGSEVTQIACGRCHTLAFIPKTGRVLSLGLLSHQQSTTRPAYRRSMSTPINISGPWAEGASTQNNLPNETPKHHKSTEQSPSEQNRKKLKEFQSNVDDEHGVLELESDLNEEVSIPEVVSAGEDSAEEMETDDIANHEVDTDFGRLRRGLRTRTTGETQDETKEERRVREIFSGGDHCFLAATFAKASEDVVDHREIPIDNHIATIDAVFMDTLEAASSTESLSEPVMSSIEEVFSSAACLNASFLKTNDEHFGSSRQNHGMDLDAAREQFRRLAGKEAVVRYVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9R6</accession>
    <name>A0A914A9R6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060508.1">
        <property type="nucleotide sequence ID" value="XM_038204580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9R6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204580.1">
        <property type="protein sequence ID" value="XP_038060508.1"/>
        <property type="gene ID" value="LOC119731409"/>
    </dbReference>
    <dbReference type="GeneID" id="119731409"/>
    <dbReference type="OrthoDB" id="448621at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052682">
        <property type="entry name" value="MZB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15881:SF2">
        <property type="entry name" value="MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="107" mass="11960" checksum="E6D6A36DB7D67EDE" modified="2023-02-22" version="1">MQANLKTIVGIKEIKGVKRLSGPGLSTKDVPGIMQGGGKWPGRMREVCNQYAGDLEEENIYNAYKENKLQNFLCYEKGRHCAKVAGSKTKDSNKKINKTKKEAKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD10</accession>
    <name>A0A914AD10_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061356.1">
        <property type="nucleotide sequence ID" value="XM_038205428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD10"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205428.1">
        <property type="protein sequence ID" value="XP_038061356.1"/>
        <property type="gene ID" value="LOC119732060"/>
    </dbReference>
    <dbReference type="GeneID" id="119732060"/>
    <dbReference type="OMA" id="VFGMDDP"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF308">
        <property type="entry name" value="BMP-LIKE PROTEIN UNC-129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862868" description="TGF-beta family profile domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="357"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="492" mass="54396" checksum="69EFDF226F73291B" modified="2023-02-22" version="1">MLLSRQSCILLVLTVCCLMVMLPHASSRAVARVDENLSGTHPSSSRGRDHPSPASNLGEGTVHHQSQSGVDEESNVIMTQQKEQVLGELFRAIGLENNTLEEPARRPQPPPFMLDLYSSIADPSSGKMKMPRPFNANTVRSLPDKADKHRLHFQFNLSHVPATEMLLQAELHLFRLKPKMRPTVTVSGKRQPFYQIQLYQLASEDLTSIEGAKLIGLRLVRSVGTEWEVFSITDAVSSWLADERTNFGVLVTISSLTGEPMDENFIRFAQQGKHHPTKHPFLVLYTSDLRQMDSAHTGQDAVESAYETFFETYGNLNSPPFTDSTQAGPTPNVNTNRYSDDKVTTTKETRTGTATSRNRRDNRQDLDTESPTEDSATAGGSSGKKASPKGTCARKSMYVDFHEIGWSDWIIYPVGYNAYECAGRCPFPLGQAVRPSNHATVQSLMHLISADVAAPCCVPSQLDPIVVLFFDSDSNVVLKQFDNMVATACGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADI9</accession>
    <name>A0A914ADI9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062000.1">
        <property type="nucleotide sequence ID" value="XM_038206072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADI9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206072.1">
        <property type="protein sequence ID" value="XP_038062000.1"/>
        <property type="gene ID" value="LOC119732516"/>
    </dbReference>
    <dbReference type="GeneID" id="119732516"/>
    <dbReference type="OMA" id="QHWVAQG"/>
    <dbReference type="OrthoDB" id="9985152at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000059">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000012">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024175">
        <property type="entry name" value="Pept_S1A_C1r/C1S/mannan-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF38">
        <property type="entry name" value="MANNAN-BINDING LECTIN SERINE PROTEASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001155">
        <property type="entry name" value="C1r_C1s_MASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 16 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 21" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 21" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961980" evidence="22">
        <location>
            <begin position="28"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="190"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="364"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="24">
        <location>
            <begin position="442"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="(3R)-3-hydroxyasparagine" evidence="17">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16 19">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="308"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16 20">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16 20">
        <location>
            <begin position="366"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16 20">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (between heavy and light chains)" evidence="16">
        <location>
            <begin position="426"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="713" mass="80501" checksum="DA9E04CC82693AAB" modified="2023-02-22" version="1">MAPTSNWQCFIAAALLCVLCFPAESCGETLQLSALHGQLASPSYPDPYGDNEDLAWNISLPQGYTIDLYFSLFQLEPSNNCEYDYVKVLSKGKELVTYCGNEIVMEDRTPHNVHLTSPNNNMLVRFHSDFSNEEPFLGFLAHYRAEDIDECAVENGGCQQLCHNFVSGFYCSCRMHYELQPDNHSCRVSCRDLLYTYESDEFQTPDYPQEYPNDADCNWVVRVESGFVINLVFQSFALESHPDVHCPYDYVTVHYDGTDLGPYCGESQADWPPNIVTSGHEVNVIFHSDNSEQRTGFHARYFVTARPCPPLTAPAHGSIIGSNFTFKQSVSFRCKAGYFVNGSSSRTCQGNGTWSGTQPFCQIVTCDTPPTISNGRILFYSGSNFSYTNSIGYECNRFYELHGMSFRECQANATWSFQNPTCVPICGESSIDPRERGSETRIVGGREAVRGSWPWQALVKVYAPEHDFVTEESFCGGSLLNEEWVLTAAHCVTGRNENRPRFYGKRVPTDALEMYLGVHNRQQHTTETLYTSVQEIIKHPEYDAESWDSDVALLRLNQSVQLTDYIRPICLPEQNRRPGRNDDSTVRIRNVADGEDEGVVIGWGRKDYNRPTSNVLREVYVGVNVPRDECNEAMEFRHVTRNMVCAGPREGGRDACTGDSGGPLMLRHATTGRYFPYGMVSWGEGCGDEGKYGVYVRTENFVDWIKSIIEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF33</accession>
    <name>A0A914AF33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062126.1">
        <property type="nucleotide sequence ID" value="XM_038206198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206198.1">
        <property type="protein sequence ID" value="XP_038062126.1"/>
        <property type="gene ID" value="LOC119732615"/>
    </dbReference>
    <dbReference type="GeneID" id="119732615"/>
    <dbReference type="CTD" id="1173"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="431" mass="49182" checksum="8737688A858F8048" modified="2023-02-22" version="1">MIGGLFIYNHKGEVLISRVFRDDIGRHAVDAFRVNVIHARQQVRSPVTNLARTSFFHIKRGNIWLAAVTRQNVNASMVFEFLMKLCEVMSSYFGKINEDNVKNNFVLIYELLDEILDYGYPQNTDTGILKTFITQTGIKSQTREEQAQITNQVTGQIGWRREGIKYRRNELFLDVLENVNLLMSPQGQVLSAHVAGKVIMKSYLSGMPECKFGMNDKLTLDKQGKGDSDSSKSKSSIAIDDCTFHQCVKLSKFESERSISFIPPDGEFELMKYRTTKDISLPFRCIPLVREVGRTKMEVKVVLKSNFKPSILGQKIEVRIPTPMNTSGVQVLCMKGKAKYKSSENAIVWKIKRMSGMKEVQITAEIELLPSGEKKKWARPPISLNFEVPFAASGLKVRYLKVFESKLNYSDHDVIKWVRYISRSGLYETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGX4</accession>
    <name>A0A914AGX4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062771.1">
        <property type="nucleotide sequence ID" value="XM_038206843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206843.1">
        <property type="protein sequence ID" value="XP_038062771.1"/>
        <property type="gene ID" value="LOC119733255"/>
    </dbReference>
    <dbReference type="GeneID" id="119733255"/>
    <dbReference type="OMA" id="HSECDIC"/>
    <dbReference type="OrthoDB" id="6048873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="638" mass="71814" checksum="436D6E28CD893CEB" modified="2023-02-22" version="1">MALAPKQINPHSECDICQEKYKRPKVLDCLHSFCEKCLENYYYSSRYEGQTKIPCPVCQRETVLPKKRIQGLKTNFHLIGKVDEVSLQEKVSCSENSKVICVVCDMGNEAMHRCLDCAQNICPNCYKTHLRCTATSHHTVATLEDIRQVKKRPEEDESKCQKHKGEVKRFYCETCEELICQDCTVVDHCKPKHHYIDSGKASLKYKQSLKDMFPDFTAGIKRLEQAVATSSDAKQKLTQNVTKTVKAVQGKADEMRAEITTQETKMIEEIKQLQPDRNRTYDEHLSTVTMMLQSKQHSLATSQDIINNASDIDFLSLYPIISKDLKLLKSQNPPQIDPKLSYVSFTPSQRIGDINLGKLAVKDRWEMCCVFGKAGCGPEEFNGARGITVTQPGEIAVADWLNDQVVIVSNEGQHKGRIPRQPKGKTPLQRPCKVAAIHNPEQRLLVLELGSKYVKVINMKDSDLVMQFPTVEQSQVRKTQMDLQSLAVTKNSILVGDIRRMVWTEHRPTDGEILHTIPVQTPPYYLAVDDNTDRVVISGCHTKEVEVADRKGTAISTIKPTINGKPVECHGVCCDSSSIYLAIHQSREGTGHIHHYDLDGRFLDCLAQGLSGPYGITFTSCGQLAVADRHSIKVYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH03</accession>
    <name>A0A914AH03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063263.1">
        <property type="nucleotide sequence ID" value="XM_038207335.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063264.1">
        <property type="nucleotide sequence ID" value="XM_038207336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063265.1">
        <property type="nucleotide sequence ID" value="XM_038207337.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063266.1">
        <property type="nucleotide sequence ID" value="XM_038207338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207335.1">
        <property type="protein sequence ID" value="XP_038063263.1"/>
        <property type="gene ID" value="LOC119733965"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207336.1">
        <property type="protein sequence ID" value="XP_038063264.1"/>
        <property type="gene ID" value="LOC119733965"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207337.1">
        <property type="protein sequence ID" value="XP_038063265.1"/>
        <property type="gene ID" value="LOC119733965"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207338.1">
        <property type="protein sequence ID" value="XP_038063266.1"/>
        <property type="gene ID" value="LOC119733965"/>
    </dbReference>
    <dbReference type="GeneID" id="119733965"/>
    <dbReference type="OMA" id="CACTSIF"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="681" mass="76185" checksum="3BFF4211C4B01272" modified="2023-02-22" version="1">MKEYSALDVCKDESNPPTAGKAIELDSETTPAIAHDQRDGEGKGDGARGSWGGWLEFILSVLGYSIGLGNVWRFPYLCYENGGGAFIIPYLIMIAFVALPIIFLEMSLGQFSSLGCISVWRLSRLFKGVGFAMTSISACFCLYYNIVLGYCIYYLVVSFYDPQPWVGCDHEWNTENCFERGSRVDEVDGPLAANSSASTLPPYATATATAMYGWNVTTPANMTRTRVRASEEFWKRQVLGKSDGLHDLGAIRWQLLLAFLAAWALIYVCVSRGIKSSGKAVYFTATFPYVLLFILLVRGATLEGSMQGVLFFITPDFKKLGQAKVWQAAANQVFLSYSPGWGGMHTLSSYNKFNNRCYRDAFIFCISCFCTSIFSGFVIFSILGFMAYDSNTNVEDVVDAGYGLAFVAFPEAVTRMWLPQLWSCLFFFMLIILGMDSQFVCLETLITAIIDELADVWPNARRWKGRLIFATCFVMFLIGLPLVTEGGIYVMELLDWYVAGFSPMVTAMSEVLIVSYVYGVKRVVRDIEAMLGFTPSMYWQLCWMLFCPALLTFIVVFAFADYEPPKTADYTFPPWADAIGWCLASIVLVYIVVYAVYYLCRESGTFVERLRRAVQPSPDWGPHLNVNRVKAGYAPLPGRGPYPKINTSDKEDAICLPASDLMTKQMTSDIDLDHHQDESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AH48</accession>
    <name>A0A914AH48_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062719.1">
        <property type="nucleotide sequence ID" value="XM_038206791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AH48"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206791.1">
        <property type="protein sequence ID" value="XP_038062719.1"/>
        <property type="gene ID" value="LOC119733203"/>
    </dbReference>
    <dbReference type="GeneID" id="119733203"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="13694" checksum="AE2D43D570826DD8" modified="2023-02-22" version="1">MVCYLMGSPYPVGSPGSSIWAYTPGSSGDWIPSSNLEDIPGTAANRMPNFPHQDTVKRGWLPNEQTPVSRFGEQHEPMSGMHHNMAMGDGGGVTAHGMAGTVWNPVATMQLHGTNPKVWGASRSQSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHG3</accession>
    <name>A0A914AHG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tripartite motif-containing protein 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062819.1">
        <property type="nucleotide sequence ID" value="XM_038206891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206891.1">
        <property type="protein sequence ID" value="XP_038062819.1"/>
        <property type="gene ID" value="LOC119733292"/>
    </dbReference>
    <dbReference type="GeneID" id="119733292"/>
    <dbReference type="OMA" id="SEDMENW"/>
    <dbReference type="OrthoDB" id="25275at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71381" checksum="F9AD314A07642EA8" modified="2023-02-22" version="1">MATALKNIGPHLECDICADKYKQPKVLDCMHSFCQKCLEKYYASRYAGQPKFPCPVCRRETVLPQTRIQGLKTNFHLMGIVEEVSLQEKVACSENTKVICEICDEGNEAMHRCLDCAQNICPNCRKTHLRCTATSNHTVATLEDIRQGKVTVKKTPEEDESKCHKHKGEVKRFYCETCEELICRDCTVVNHSKPKHHYIESGEASRKYKQSLKDMFPNVTTGIQILQKAFATSSQAKQKFTQNVTKTVKAVKDKADKMRAEITTQETKMIEEIKQLQQDRNRTYDEHQETVTMMLQSKQHSFSTAQDVINTASDSDLLSLYPIISKDLKSLKSQNPPQIDPRLSYLSFTPGQRIGDINLGKLEVEAGKWEKCCEFGEEGSGPGEFNGAVDITATQPGEIAVADFYNNRVVICSNEGQHKGTIPLQHPVAVAAIHNPEQRLLVLESGSKYVKAFNMKDNTLVMQFPTVPKHQVDKTEMNLRSLAVKNSTCTIIVGDVKRMVWTEHKATDGEILHTIPVQTPPHYLAVDDDTDRVVVSGWDTKKVDIADSKGTTNASIKPSINGKPVKYCEGVCCDSSGIYLAVRQVVSGTGHIHHYDLDGRFLDCLAQDLYLPRGITFTSNGELAVANRFSIKMFHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHS8</accession>
    <name>A0A914AHS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063272.1">
        <property type="nucleotide sequence ID" value="XM_038207344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207344.1">
        <property type="protein sequence ID" value="XP_038063272.1"/>
        <property type="gene ID" value="LOC119733966"/>
    </dbReference>
    <dbReference type="GeneID" id="119733966"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="121"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="253" mass="25627" checksum="F2E6E8BA5ACF967E" modified="2023-02-22" version="1">ALLLGNSVNLRASVTGPVPSDGDGPASQACPMCCQGSAAIPGIPGLPGSLGQPGSKGEPGQKGDIGSIGPMGERGAAGPQGDEGIGQPGKIGPRGVPGVVGPTGETGVKGQKGEPGEAPDDSNQRVAFTVVRTSSSDTSTSHDTRLPFQATETLLPGTSFDLETGTFTCGVPGTYVFMFSVCKYSPSSALYVYLRKNGDAVVSGRSSDSSHNEQVSGSAVVVLQRGDTMYLTMHGRAVGGSWTSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI15</accession>
    <name>A0A914AI15_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063029.1">
        <property type="nucleotide sequence ID" value="XM_038207101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207101.1">
        <property type="protein sequence ID" value="XP_038063029.1"/>
        <property type="gene ID" value="LOC119733718"/>
    </dbReference>
    <dbReference type="GeneID" id="119733718"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="208" mass="22463" checksum="9554B1B01E16898A" modified="2023-02-22" version="1">MDEDEYIRKEKRREQKAKWAKKKRDALRIVSVLEEVRRRPLCADAPGNSAPGPSNPVNDVSSPVNLDSCDGTSDEEGSTDHAVHVEVDEETVTEDELFERQLQEIFGDSSPNPTNRVYNASETGSPDGNAYNYSSTSDEDGDNEEGDDVTAKPNGNIRSSASPGYDTPGPASPSYDTPGPASPGYDTPDPASPGYDTSYLPLLLMTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIF8</accession>
    <name>A0A914AIF8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063326.1">
        <property type="nucleotide sequence ID" value="XM_038207398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIF8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207398.1">
        <property type="protein sequence ID" value="XP_038063326.1"/>
        <property type="gene ID" value="LOC119734023"/>
    </dbReference>
    <dbReference type="GeneID" id="119734023"/>
    <dbReference type="OMA" id="VANEDCA"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="195"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="380"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="547" mass="60647" checksum="9A9BE5B7582BF78E" modified="2023-02-22" version="1">MYREGDRRLITFLAVYSTVTSWEHARSFGHVSQTTLRAATTTVPPVLSCGPDSVPYAGECLHIFHRPSKWLDADAVCQHLNGARLVTIVDQAMNDFLAGIIRDDVWIGLHDTHEEGSWRWVDDTPVNYTNFNSGDGTDQRGDADVATVSPEHTTNCVVLRSGTGKWKDVSCHSTKGSICALPRGEPLCPDGGTFFRDRCYWYNLVNNWDNANRDCENRFGSGVKLVIVRDAELNAFLSRHVHPTVWLGLRYNHGDDTWRWVDGSPLDHNGYERWSDGELENMQNGRDCAVLNHNDVNGGHWSRSYCTPYTRTVCALQTCYDGPGGGSGAGNGDTDSPDEEPNCLDFGDQPKCSCVSNALCRLTGKCHCDPLFDGMKCDKDELTVTIHAPRRVERGANVTMRCHVNLPSTDVTVLWRKVSGTEMLPEGRTRLQDRPEVGDYDLIIENLQENDTGSYVCAATTVIGQIGESEMDSTYLHVAVPDVPTPLTPGKVYEGNNEGLSSRETGLIVAVGLLSVCFVCLLIAFIAVQVRHAFTQRHTRRPSDMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALM3</accession>
    <name>A0A914ALM3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064446.1">
        <property type="nucleotide sequence ID" value="XM_038208518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208518.1">
        <property type="protein sequence ID" value="XP_038064446.1"/>
        <property type="gene ID" value="LOC119734893"/>
    </dbReference>
    <dbReference type="GeneID" id="119734893"/>
    <dbReference type="OrthoDB" id="19938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053964">
        <property type="entry name" value="INT1_R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053965">
        <property type="entry name" value="INTS1_R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="3">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="242" mass="26791" checksum="EBF7CFD61C34AB56" modified="2023-02-22" version="1">MFAVRFLKATIAMVTVLLQGRTHLNFKEFRIRGHLRFFNHILGILQLLEPQLFAQPSTVLHGIMEAYFPILPHSVIAKKPLESIITKFIQLLYQYSSHNPTQAQPLLEKHSTALNNLSQVYPDIQQLKSLLASITLTSSSKDQSGLGSAPNQAEPAMDEIPGVGGREETYSPTLAAMMGADASWDTEDVKSFAERLSQEEDSEGMAEALNELEEKSSSAVGIPQHFVAELSTQMTSCNKDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANT1</accession>
    <name>A0A914ANT1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065407.1">
        <property type="nucleotide sequence ID" value="XM_038209479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209479.1">
        <property type="protein sequence ID" value="XP_038065407.1"/>
        <property type="gene ID" value="LOC119735670"/>
    </dbReference>
    <dbReference type="GeneID" id="119735670"/>
    <dbReference type="OMA" id="RFSPMML"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="63"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="48995" checksum="74AE969B4EE84D55" modified="2023-02-22" version="1">MATESLNTSYASTCNCNHTDMRVLVANNHHPVSNHASLNQISIGNVSNSTSSSQMIKRRTRLVEKDGTCNIQYENMSKSRWCKIIKDIFTSTVDMPWRYNILMVIVGFLASWLLFAVLYYGLAIARGDFDHLDDPEWKPCFRNFQNFKSALLYSIEAQTTIGFGFRSPTEQCGEVLFFLIVHTLWANFIEAFILGSFIAKVSRPKARAKTLQFSHYACMTKLDGKMCFTFRVGDLRQKSHIVEGHMRLQMVRHYVTKEGNVIPFKFLDLNIGHEFGADRLFLVWPLQIVHVVDEKSPLYSISRDHLRHMDFEIIAILEGIVEATGTTTQARTSYLPDEIMWGFQFENMVEVRDDCHFVDMKRFHMMRESEDFSRCSAKEVDEMREAEDREVDRDSVWTSRRNSGIIRRSSPILRDAENVESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQN4</accession>
    <name>A0A914AQN4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065721.1">
        <property type="nucleotide sequence ID" value="XM_038209793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209793.1">
        <property type="protein sequence ID" value="XP_038065721.1"/>
        <property type="gene ID" value="LOC119735855"/>
    </dbReference>
    <dbReference type="GeneID" id="119735855"/>
    <dbReference type="OMA" id="HEVRKCP"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="573"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="864" mass="97621" checksum="068B8F614BC2B40E" modified="2023-02-22" version="1">MTIDPNATPVVRPPRRIPAAMQDKVKSELQRMTTLGVITPVSEPTDWVSSMVATHKKNSEEIRLCIDPRDLNEALKRPHHPTRTVEEVAAKMDGATVFSVLDAKCSFWQIPLDYESSLLTTFSTPYGRYRYLRMPYGLCSASDVYQRTMEQIFADLPCSIIVDDILVGGRTKEEHDRYLKTVLDRIRKINMRLNPTKCRFGLEQVSYVGHVFTASGLKPDPAKVSAITDMPPPNDVTALQRFLGMVTYLAKFVPNLSDLTAPLRELTHSDIHWCWLEQHNAAFLAIKDKIANAPTLTYFDVRKPVTLTCDASKFGLGAACLQEGAPVAYASRTMSDTEQRYAQIEKELLAVVFACTKFHDYIYGKDIVVETDHQPLVTIVKKPLLSAPARLQRMLLRLQRYNITLVYKKGKELFLADTLSRAPLTTTGTETDDLQVMTLLSISDMRLEQLKKATACDSAMQQLTDVISRGWPSHINNAPPKAHPYFAFRDELVLDRGIILKGHKAIIPKSLRAEYIQILHEGHPGIEATKRRARDVVYWPSMCLDIEQSVSGCTVCNATKAHQQKEPLKSYPPPSLPWEHIGVDLFHWNGMDYLALGDSYSGWFDFASLDNTCASTVIEVLKRQFSIHGIPRIVISDNARQFDCFAFKQFAQSWGFQHTTSSPHFPQSNGLAESSVKRAKQLLEKTKRDGSDLYRNLLNIRNVPTNPQLGSPSQRLMSRRLRTTIPTPTPLLKPAIYTRVTAQLRKRQQQQKSSYDKSAKPLRPLKPGQVVRLQSPKGHDQLGIVQKHSRNPRSYIVNAQGTLYRRNRRHLLPVSEPPPEQQHSPDFYLPPQDPLPQPAIPHAPPPQPVLTRSGRISKPNPKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARK6</accession>
    <name>A0A914ARK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066402.1">
        <property type="nucleotide sequence ID" value="XM_038210474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210474.1">
        <property type="protein sequence ID" value="XP_038066402.1"/>
        <property type="gene ID" value="LOC119736456"/>
    </dbReference>
    <dbReference type="GeneID" id="119736456"/>
    <dbReference type="OMA" id="MENTSYC"/>
    <dbReference type="OrthoDB" id="6109871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="43"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="413" mass="45571" checksum="674766BB5B041B08" modified="2023-02-22" version="1">MENISLSNSTDTFEGLDESSYSTGRYVYRLLVRAAVLVLGVPGNCLIIRVYWTKTRKTSTHVFIMALAWADLAACLLEIHSIARDALEFTGRELHPAFFFILAFQNAVIATSVVTTGIIAADRYDCVCRSQKRFFTPRRAKACAVTALLYSVVISVPKFINAFPGAPVSVAAGVLPYALQMFSFMVVLVAIVVCYGKVYATIRRHVRSRVAALPGPTPADDFDGLRPWHSPTAPGVAIIDNVASMIANRESASCNTRNVPSATSPGRAIKLHHWGPGKLDRDPGDSRIRTTQQTRCDGFSSAKQDPPAAVIGRYPGEGPRRTRSVAVLQRKTTRMLFVTSNVFVVLWLPYWIFVTLHIAACAGGNVSKTALQFLLDFHMVLLMNHAINPLLYGAANRRFRRDCREAFKKTKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS65</accession>
    <name>A0A914AS65_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066299.1">
        <property type="nucleotide sequence ID" value="XM_038210371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS65"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210371.1">
        <property type="protein sequence ID" value="XP_038066299.1"/>
        <property type="gene ID" value="LOC119736361"/>
    </dbReference>
    <dbReference type="GeneID" id="119736361"/>
    <dbReference type="OMA" id="YMLICIL"/>
    <dbReference type="OrthoDB" id="6093123at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037173247" description="C1q domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="168"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="310" mass="33319" checksum="51121F9B23EA97FA" modified="2023-02-22" version="1">MTNLTSRLFLGLPLLLLLSATGTLALSTFHQDVAFSYIDTEDITQFPRNTYDEPPLLDRLGTGPVFVASFPGTYVFTFHAPGTGKNFSGPPSRINYQFSWSPGGVNAQSVLRLTGDGPVAGHALLDLQSDDHVMIEILNGSATPIVNTTTPVIFNGFLLYHRCLCSPLVLRQSAFSASRKSTGLGPGTLFIYYFEMDLGREDEFDTANGIFTASLPGIYVFMYSFPNQGVGRPGSVTVSLTVNDAVKSSVTSVSSAAATVEYAGTTVVLDLVVGDRVRLEKRGGQLDIPEVYVGGTLEYVSPILFSGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASQ6</accession>
    <name>A0A914ASQ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066802.1">
        <property type="nucleotide sequence ID" value="XM_038210874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASQ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210874.1">
        <property type="protein sequence ID" value="XP_038066802.1"/>
        <property type="gene ID" value="LOC119736864"/>
    </dbReference>
    <dbReference type="GeneID" id="119736864"/>
    <dbReference type="OMA" id="GHAVAMI"/>
    <dbReference type="OrthoDB" id="6493031at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="48470" checksum="C027AA3CDAEEC767" modified="2023-02-22" version="1">MGDAERCSYRCWHAVLGLRLHVDWLLWAGLLKGLGMMLPTLKEQFTAETWMIGWLIATFNGAASFTAPLSVPLEDKFGTRAVVTVSGFLVGTSMILSSFSNTAIQMMLTSLITGPGLSIVNVLARAAMGRYFTTNYTSANGIGTSGHAVAMILIAPITLLLLDTYEWRGALVLLGALYLHLGVCGLLLTSSPIAPTQAQDEYLPIISSEEEKSPPDKASHDTKNAFKLSNVKGAIWAHRNLLLGCQMCWRVEFWIVSLVYGCAFFVSSLWLIYFVAYTEAKGFSGYEAVTFTMAGGIGNLVLKIMVGVIVDRGLLKLRLSMSVMIIVNSVALLVLPWMNSYWLMVANAFIFNGFNGALSSLIDIYTRELLGAEDLLSAFSLMDLVATAFQQTLGFFPGWMFDRTGSYDTAFVILGCVAMLPLVAPFMERVLNRWNWKEQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT36</accession>
    <name>A0A914AT36_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038066639.1">
        <property type="nucleotide sequence ID" value="XM_038210711.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210711.1">
        <property type="protein sequence ID" value="XP_038066639.1"/>
        <property type="gene ID" value="LOC119736697"/>
    </dbReference>
    <dbReference type="GeneID" id="119736697"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1282"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="578"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="676"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="779"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="872"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="973"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1173"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1448"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1625"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1737"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1918"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1345"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1381"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2009" mass="219785" checksum="15A7B562A1763B17" modified="2023-02-22" version="1">MSSIVRDCYFNFARGVGQFQSDNPNVLPGMSGCKENKWDLTTCESACPLCFNGGICDDRSGDCICPPGFSGDICETPEGPNRFGQSGSFGCDSSELGGGPTCAGMLFCLPDPYGCSCAAGYQGIDCDETCAEGFYGANCEQRCHCMDGVSCNATTGECRGNCAPGYTGINCQEKLTFDDFTCITKPRIDIDSEYTYIAAYLHGGNANLSFARTTYTYTSVDNINDPLGLPSYHRLKPRSSSEGDEISILRLPAAGGKTRIGAFACNAMIAGSGNVSIGTVIMSKTADFLPTRVSQTVYRGDAVNLTVTATARTNTRWRKDGGEVFPGRHGSLYLDFINASVADTGIYEAHFAGKRSDGKQALMRLIVRGCKRNKWNPPLCNADCPVCFNGGICDDRSGECICPPGFSGDFCGIPEGPNRFGQSGSFRCEELGGGPTCAGMLFCLPDPFGCSCAAGYQGIDCDETCAEGFYGADCAQTCHCMDGIACDETTGQCPRDCALGFIGINCQACDNYTYGQDCRLCHCMDGVACNRTTGECFGDCAPEFTGLNCQEICLPYNGIASCSTTCTEFPDSATESFVPQNVSSFTLDDSDASRTFTWQPVSCPNGVMIVNYVYKFGLVESDQELEAVRAEGNSVSVHLSPCGTRYGFEVAAETTEGIGSFSYKHLFTSNSKVPDAVDKLTVEGTSHNSVSLLWDAPGTSQEYPCLASDYLVTFDLINLEQCLEVHQHGGSVTTTDTSITLQGLKAYSTYNVSITPRNEAGNGTISSLRFITRETIPQVLPEFIGSPATTDSITWTWNPIPCGKKGGNIIGYETRLTSSSLINRTSTSTTSVTHTDLEPCTNYTLGVSAYSSKRSGLWLTVHQRTATDVPGPVSHIFILAISRERNEFDVRWTSPKGPCPATSYKVTYELIRMDRCMQQNPPIVIDVGTVDTTHVTIHLPAYYSKYRVNVAPINEAGHAQGSFKIIVTNENVPSASPVIRGTATNDSVTFSWDPIPCGSRRGNITHYEYRFKGPRPQEKGKTNEKSNISKLSVTFRDLSPCTTYSIRVRAFTRIGAGLWANWTHQDTVVIDEIQSFNLDPSTNKIRTSWTTAGNEDNPCPVTSYRVSYQLLNLEQCQPRTDLAVINKTVVNGSGIEFTSMHAYSTYNVQVVPANNAGAKYRKSKTVTTDEGVPLAAPVVDTMLPFNQSVRVSWHPIPCGKRGGNITGYTYELRDASGSMVKTADTTAESVEVDGLSQGASYLFRLWAFTRVGPGPWKEGDFEIPKDDAAPPTPPGSSPAGSVLGVVVFILVVAVLALLIVVVVKKRRQQRTKALSKDITGDCVQDIYGKGDQVGVELKNLPSTSGYKPYATKDHEPVVSSTNPPKSTDQVAVDVLPKVGPSTDSASASGPSTSTKAPVKPKPYVNPSTKPKLKASAKTSPSFSQAGPVAMAQLAEYIKSRTAGKINGFQQDYESIQSVPIHSWNVAKLEHNKKNNRYNNILAYDHSRVVLECLEDNPHSDYINASYINGYKHDSKYIASQGPTKASVRDMWRMVWQERVGKIVMLTNLIENGKGKCEQYWPASEGSANYGDLFVRHVDETKHANFIERIFHLSKSTEPEGEYRELTQFHYTTWPDMKPPESSPLLQFVRRVRATDASQHGPMVVHCSAGVGRTGTFITLDSMLEMAEAEGQVDVLRFVRDMRDQRFLMVQTLDQYKFIFDALLESSLSENTAISADRFHQSFAKLKKRDKKTGTTGIEAQFQMLESFTASPSEEQCMGGRSAANVDKNRFKDCIPKDSTRPYLMTKGDEGSTNYINATFLDGYNSKHAYLATQAPLPNTRGDMWRMVFDYKASCIVMLNSMDNDPSVVQYWPEKDSLEFGPLTVTLTNEDRYSEDIIIRQFDVSYPARKNDEVQSVCQIQYLGWPPGKEVPRSPSSLLKVLEAVKMWTTDHPDGPITVHCIDGVGCSGTFCALLTLLDQLAVEKDVDVFQAIKKLRITRAGMVNTLAQYQLCYQVIQTYLDSGSIYENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATI1</accession>
    <name>A0A914ATI1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038066978.1">
        <property type="nucleotide sequence ID" value="XM_038211050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066979.1">
        <property type="nucleotide sequence ID" value="XM_038211051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211050.1">
        <property type="protein sequence ID" value="XP_038066978.1"/>
        <property type="gene ID" value="LOC119737002"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211051.1">
        <property type="protein sequence ID" value="XP_038066979.1"/>
        <property type="gene ID" value="LOC119737002"/>
    </dbReference>
    <dbReference type="GeneID" id="119737002"/>
    <dbReference type="OMA" id="TWMNPWQ"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="89"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="59332" checksum="8D87CA5C153FAA56" modified="2023-02-22" version="1">MDARVTALSNSTMAAADAILFNKPVEVPLPSQYHRLVHLDLKRAPLKMEFLTKLIVKLKEWGATGLLVEYEDTFPYTGELAELALPNAYSLADIEALQQITRDNDMEYVPLVQTFGHLEMVLKHNKFVHLREVAEFPTSICPSKEESLLLIQEMLEQVIQAHEGLKYLSIGGDEVAHVGLCHKCQHRIETDLGGYTCSLYLDHMTKVLRYMRKQHPGITCIMWDDMLRTINPKIMNDFKLGELVEPMVWNYSDDITSFRLRFHQGMWQNYAQVFKHFWIATAFKGSFGHTLYWPPVKLQVKNHLLWLQELDKEIPKTLALRGYALTGWQRYDHLSVLCELLPTGIPSLALCLQVLLQGGYSHDLLERVSKQLGFSEPFQLEFPQHIESLDPKVAFSGSDVYSAVQDLVIFESSSRFKDFMSQSQLHANTNPNASIATDLPMVHYSVEESATEAKSLSGQLDAIRQRARAALRNVYHTTTNEEWLELRINPILRALKMFVGGGSMDEVKEEDEDEMEVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATX2</accession>
    <name>A0A914ATX2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066939.1">
        <property type="nucleotide sequence ID" value="XM_038211011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATX2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211011.1">
        <property type="protein sequence ID" value="XP_038066939.1"/>
        <property type="gene ID" value="LOC119736965"/>
    </dbReference>
    <dbReference type="GeneID" id="119736965"/>
    <dbReference type="OMA" id="NITWIGH"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="439"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="690" mass="77237" checksum="FF8C13EF3D29B730" modified="2023-02-22" version="1">MAVHTEQPTQLAFQEILGVFSNNIYTAVAADTYSYSPEEQVIQVVSIDVSNTDPLSTTLDENLEDNSVMGPTTDRLSGEMDCTRVPDSTVQEGTFFTKPENWDPILRNSDPMLRNSDPLSSLDHLEKTDIDQDDSRNSGSLSIVDPLDYNDPLNTMEPYAEILKPRGLFSQKTEIVSSSSTEAIVNQPTSNFPDPTRICDALPDIPATKPVPNYVSVHRKQPEKLAVTPERDQRITRVAAILRGDYGHSNTNQSNQDGLGLLEYIDDGYSTISKYRDDKEDDGNGDWRQPPEISGKQSESVLRQPKSHASGPSNSSSTTRLSSCAFGLEINTSRQKLLRDDKVRFGTLDPRKMEDVTSSVLRNGCYVNPWDTWKEPSCGSGFKFMCTRSERLPSKQELDLNLPVVTPDFNKICAPPSSGINVTWFGHASLLVQFDGVSILTDPIFSSFCGPASLVGYQRYRPAPCTVDQLPKIHAVVISHSHYDHLDLPTVKQLNNRFGKDLRWFVPIGLKDWFIKTGVEDVIELDWWQANCIPSHSKVAFTFTPAQHWSMRKGYDRNKSLWGSWSIIGPNHSFFFAGDTGYCEAFKEIGQRYGPFDLAAIPIGAYKPRAFLSPQHVNPPEAVQLHLDIHAKQSVGIHWGTFQLGKEGYLAPLEDLKIALDEARLTDQDFFTLKHGETRLLAEEEDQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVT7</accession>
    <name>A0A914AVT7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helically-extended SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068215.1">
        <property type="nucleotide sequence ID" value="XM_038212287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVT7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212287.1">
        <property type="protein sequence ID" value="XP_038068215.1"/>
        <property type="gene ID" value="LOC119737733"/>
    </dbReference>
    <dbReference type="GeneID" id="119737733"/>
    <dbReference type="OMA" id="RAHFENE"/>
    <dbReference type="OrthoDB" id="10071033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043443">
        <property type="entry name" value="FYB1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029294">
        <property type="entry name" value="hSH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830:SF12">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830">
        <property type="entry name" value="SH2 CONTAINING ADAPTOR PRAM-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14603">
        <property type="entry name" value="hSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helically-extended SH3" evidence="3">
        <location>
            <begin position="497"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="599" mass="65452" checksum="13387AE1E592EDFE" modified="2023-02-22" version="1">MSCGEVEDLQEGSSDSKEENSVKNIASMFNQPNQSAGMARPAVAAKPTVGSKPSVLAKPPGKLDLNSSIKIIGPNVRSPRFEKPSNGAVKSPSKDSLKRDSPKPAAAPAKAPVGGPVMPGTNMAEILNMRNMLKKAPVPAPSPTTSQSEPRVDFKRSLKKSPVAPPTRTTPSLHQKTAPPSQGTDEMDTSSKENISTSKSEGDCSSLSSFTSDSSIPRRGSATSQKTTGDNQKPILEILPPLETIGPAPRKPAKPVNVKLPKSAAMPPSANPEPIDSGADSGEIYDDVAVETNKRFSLIPTMDSDEETGDDIYDDTEVVPSAPLPPLPACLSIPTIAQTSGPDDGPQEIYDDVSLEGESEELYEALDVSTEDAQQKRQPEKTWPKVKTKGRSTSVGSTCKKNRPTSKWYVSRDAAATDVKRPSIESSDSADVASRPTTTPSSLLSPRKTMSTKKQEEKQRKEQERLEKERRKKEEEMRKKREKEEKKRKEKEEKEMKKKFNIKGEIQVLDSGTVTQDCGSDYERTDLICKRGDRLEVLRRDGNPPGKWLARDLQGRYGFVDADFVAIETDFQEPYDDVIPCDGSGSEEEEEQEIYEAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVZ7</accession>
    <name>A0A914AVZ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GlcNAc 2-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetyl-D-glucosamine 2-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Renin-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N-acyl-D-glucosamine = an N-acyl-D-mannosamine</text>
            <dbReference type="Rhea" id="RHEA:19033"/>
            <dbReference type="ChEBI" id="CHEBI:16062"/>
            <dbReference type="ChEBI" id="CHEBI:17274"/>
            <dbReference type="EC" id="5.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19034"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:19035"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Forms a heterodimer with renin and inhibits its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N-acylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038067868.1">
        <property type="nucleotide sequence ID" value="XM_038211940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211940.1">
        <property type="protein sequence ID" value="XP_038067868.1"/>
        <property type="gene ID" value="LOC119737517"/>
    </dbReference>
    <dbReference type="GeneID" id="119737517"/>
    <dbReference type="CTD" id="5973"/>
    <dbReference type="OMA" id="DDLKYCW"/>
    <dbReference type="OrthoDB" id="414129at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050121">
        <property type="term" value="F:N-acylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00249">
        <property type="entry name" value="AGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000021">
        <property type="entry name" value="N-acylglucosamine 2-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010819">
        <property type="entry name" value="AGE/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034116">
        <property type="entry name" value="AGE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15108">
        <property type="entry name" value="N-ACYLGLUCOSAMINE-2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07221">
        <property type="entry name" value="GlcNAc_2-epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="15">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="239"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="725" mass="81603" checksum="4F2C19DCC5427E7A" modified="2023-02-22" version="1">MRKAEMETIKDQYKDGQAKMLGIIPPQMPLGYIVETYPAHRPSGFPAVSSPVLENNTFIPGQTLPSSGGVKRPALAGISPIDLTTSATNLSAHSLDGDDGRYPRGSYHLQSPDGRLQDNVIMQCEEIPDDDDTSQFEEGVEVLSDASSFGSEGGSALEGYREDDEETAEQDSTDMASLDETLFPHTYSEVYTQRSVAYVISGYAYTKNRQQLDKTYLRCRQRGCGARAMIMGDIRRATVFNNSHNHPPPSDITQKARKRRYSMSPPSDSPSEGIGGGPDSVSSVQMMPPSRPHPGGGAWKSMPPGSQSDAIPRIVYVRSLQSSKMATTAKARLPEFLEMMERELDRVMDFWLKNSHDTINGGFYVCLGRDGKRYDDLKYCWLQGRQVWMYCKLYNNLPKYHTPEILQAAKKGGQFLMNYVKNPTTGKCYFTVTKEGKAVKVQRTIFSECFYMLAMSELARATNDDVYKQEAIKMLDQLQHWVCVDDTALGRPQLLGAPRVNSLARGMIFLNLLDELTAGDPALQEKYASLEKWSIEQSLQHMQREGTVILETVSTEGKELPGSAGRLMNPGHAIETGWFLLQCGTKHELAELKKLAVDNFIARPFQTGWDQEHGGLYSFLDVDGLSPTQLEWNMKLWWPHCEALIATLMAYRETKEERFLDMFEKVFDYTFSRFVDLEHGEWFGYLNQEGKVTQDFKGGPFKGCFHVPRCLLLCTQMLQKILKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWL2</accession>
    <name>A0A914AWL2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067894.1">
        <property type="nucleotide sequence ID" value="XM_038211966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWL2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211966.1">
        <property type="protein sequence ID" value="XP_038067894.1"/>
        <property type="gene ID" value="LOC119737536"/>
    </dbReference>
    <dbReference type="GeneID" id="119737536"/>
    <dbReference type="OMA" id="VWNMENV"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF6">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="11">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="618" mass="68919" checksum="01A2E27DE9A4DBC8" modified="2023-02-22" version="1">MATSVFAEEPSVHLFCPSCKHLLQDPVISVACGHTFCRLCLTDGKDSVILEACPVDEKPLKNTSVVANRAITSQLDDILVYCKNGIKRFSSRNDELVTDTCGCPELVHLSQKAEHESSCPYSSLACPNSPECGVIQRLHLEDHFLSVCPYVKCRYHEQGCTFSNKSQAVEDHCQSCKYKEHPGYAADSISKQSFEEQILLQKQVQMLIEKVLFLENGRDEMKAQLDACTRALADMETKCNDLKSTITKHDAKLSSSSFNRSQRPSIRPRTASDRRDSSSPENTITSHDHWQVPFEFKCIGTLRGHDAAIHCLATRGHKLYSSGADKVIKVWDVDALSKGCVQNIKGHTDTVNALLAGSDFLYSAGEDQTLRMWKYDTMKEHKCIKKAHDSAICALVKNGKYLFSSGYSTIKVWHVNTLESVTTISGQHHWVRALTLEPSKEVLYSGSHNTVCLWDATGQFNLKRKLEHEYGSVYALAITSKYIIMGTRGESGKEEGSKNSLEGHSGSYNRNMQLFDVITHQHVKCLGGHIGIVTGLATSPAGQFVISSSYDNTIQIWDLQNFLSLQVLSRHQGSVNAIVLCHSLLFTASEDKEIKIFKYFRLITYSSFGNHILPGKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZI1</accession>
    <name>A0A914AZI1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068929.1">
        <property type="nucleotide sequence ID" value="XM_038213001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213001.1">
        <property type="protein sequence ID" value="XP_038068929.1"/>
        <property type="gene ID" value="LOC119738217"/>
    </dbReference>
    <dbReference type="GeneID" id="119738217"/>
    <dbReference type="OMA" id="WILCKLV"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="333" mass="37630" checksum="E44A74250971A835" modified="2023-02-22" version="1">MSVQNGTNDIWIENASHLMDAVKTIIACLAVLGNGMVITVMLLRRRVFSSFTNRLILHQSMCVAGVVFLVWQVVLLNILTPMSLKGTIYDQLMCRLIYTDVPFWCLSVTSTYNLVMISLERFMATCHPVKHRNCGSSAKLRFAMGTTWAIGFIYGSHFTFLLKAGREGCQMTQMEIGLKIFATSVAMVIEYLVPITILIYAYSRITIKLAKKSANPMYRPRIDMNKAKKNVLVTTMLIGLMFAVCWTPTVVNHVRSLITGIKGDLSYAVATSLVSCNTFVNPIIYCWKYEHFRLELRSLFIRRCRRNRVEDGNAIPMPAAVTRMNPNLAVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZJ0</accession>
    <name>A0A914AZJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069088.1">
        <property type="nucleotide sequence ID" value="XM_038213160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213160.1">
        <property type="protein sequence ID" value="XP_038069088.1"/>
        <property type="gene ID" value="LOC119738313"/>
    </dbReference>
    <dbReference type="GeneID" id="119738313"/>
    <dbReference type="CTD" id="51069"/>
    <dbReference type="OMA" id="EHNKEHV"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000157">
        <property type="entry name" value="39S ribosomal protein L2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF73">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="197"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35894" checksum="2E6545B939D03B83" modified="2023-02-22" version="1">MALAAICRSLQSLALKSQQDCQQQIIRTIRHQAVRSQTLSNHLTSGWMPTSSAASSVCLLRQREAHKLVLSPSRPEIHTSAVVGKFIPWKNTPKYTIRAMGLKQSAGRNKTGRVTITGRGGGHKRRYRMIDFKRIGPEKGEPYMEKVLGVRYDPCRTANIALVAGGNHKRWILATVNMEAGDIIKTSGTIGRMTVAANEGDAYPLGALPIGCLVHNVELFEGEGGRFVRAAGTSAQVIRKTGGQVILQLPSKQQISVSEKCMASVGRVSNEEHNKRPIGKAGRNRWLGRRPSSGLWQRKGGWAGRKIKPIPPIKVYQSAGKKGTHIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3L7</accession>
    <name>A0A914B3L7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070096.1">
        <property type="nucleotide sequence ID" value="XM_038214168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3L7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214168.1">
        <property type="protein sequence ID" value="XP_038070096.1"/>
        <property type="gene ID" value="LOC119739290"/>
    </dbReference>
    <dbReference type="GeneID" id="119739290"/>
    <dbReference type="OMA" id="HKIKIPW"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF102">
        <property type="entry name" value="RH30783P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="178" mass="19204" checksum="44C8DABE46D31DF9" modified="2023-02-22" version="1">MADRKQIVLPTISSLTNVPTGLKYLTLPEGILEIIEVACLMIAFVCVTAAPNKSPDESSYWHYQAATMGFGLVTVLIMIGYMTGVVHKIKIPWSVLEIVYCAAAGLLILTTGAHIAANTFGNAALIVATVFGFIAALAYIIQIFFAIRAWKRSIIADTLRMVEAERAQHTGATTDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3P9</accession>
    <name>A0A914B3P9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP-3 complex subunit delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070429.1">
        <property type="nucleotide sequence ID" value="XM_038214501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214501.1">
        <property type="protein sequence ID" value="XP_038070429.1"/>
        <property type="gene ID" value="LOC119739525"/>
    </dbReference>
    <dbReference type="GeneID" id="119739525"/>
    <dbReference type="OMA" id="QMMGYDI"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000055">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010474">
        <property type="entry name" value="AP3D_dom_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058898">
        <property type="entry name" value="Mu_AP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06375">
        <property type="entry name" value="AP3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26171">
        <property type="entry name" value="Mu_AP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01354">
        <property type="entry name" value="BLVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit delta" evidence="8">
        <location>
            <begin position="667"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1257" mass="141134" checksum="3EEBF795A35CC3EB" modified="2023-02-22" version="1">MALKKVKGSLERVFDKNLQDLVRGIRNNKDSEAKYIASCIDDIKQELRQENIAVKANAVAKLYYLEMLGYDISWAAFNIIEVMSSSKFTFKRIGYLAASQSFHEGTDVLMLTTNMIRKDINSTNQYDASVAMNGLACFTSPDLARDLANDLMSLMASTKPYIRKKAVLLMYKIFLKFPEALRPAFPRLKDKLEDPDPGVQSAAVNVICELARKNPKNYLSLAPLFFKLMTSSTNNWMLIKIIKLFGALTPLEPRLGKKLLEPLTNLIHSTSAMSLLYECINTVISVLISLSSGMPDHSASIQLCVQKLCILIEDTDQNLKYLGLLAMGKILKTHPKSVQSHKDLILDCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMIHVDRAEGSQYRDELLAKIIQICSQNNYQYIINFEWYVSILVELTKIEGTKHGHLIASQMLDVAIRVKAIRAFAVQQMAKLLENTSLLVGSAAQLNGICEVLYAAAWIVGEFSDFLLEPRSTLEAMLRQRVTSLPGHIQSIYVHNIIKLYSAILMKLEPDGEKEQITEVTQLISEKLPVFAESANLEVQERACCILQMLKYINKLQEKDVGVAEEVAALFAGELNPVAPKAQKKVPVPEGLDLDKWINEPPSESSDDEVTIDTMFVHDAHRGTSLRVSHKTKYEEPNEDELRRRRDVRREEQASNPHYLKDSRKKKLKDLAAENDVTVDGIPVAKIDLNVPLHVPGFNVTDEYMKKSKTSKKHRKKHKKGKRGRHISESSDDIKVAHTVDIVGEEMPEGATFSDDDEDDRALDDPHRALDIDLDRPLDDHDKIPIREHRVVAAGLKMETGQEATEIAEGEKPKKKHHHHRKEKEHKEKKSKKDKKHKKKSAEAVEETPATNEEAVDLMPGMEEAEPTRTNGQITDAVTQANTAGAEAKPEEPAKDDLSFWLSKASDEPSVATVVEDAPADTSEPPPEEKHKKHHKKEKKAKKEKKEKKKRSHKGHHGDEERLEEEETGRTEQMENGTVQESAPEVVIPPMSSYRLLAENNSIKMMYETRVELKTQNQVVVSVIFSNLTSSHLKSLDFNVLDSLNTRLIRVDLTSQHEGVKVPFQLPPGMTNEGQFAFTVKSITMAQKLRGTLTYMLKDDAGSTSEKIDFKVHLPVSAYFVPKQCSSAEYAELLSGGDLSSKQSMTIPNIEMDFSIVLARVHFFGHLSLVERVDTTASLYGQSIQGHQVCLLLKALPNKSISVDGKSSDSSLLSSLLDDVKTFLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3U0</accession>
    <name>A0A914B3U0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070696.1">
        <property type="nucleotide sequence ID" value="XM_038214768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070697.1">
        <property type="nucleotide sequence ID" value="XM_038214769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3U0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214768.1">
        <property type="protein sequence ID" value="XP_038070696.1"/>
        <property type="gene ID" value="LOC119739732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214769.1">
        <property type="protein sequence ID" value="XP_038070697.1"/>
        <property type="gene ID" value="LOC119739732"/>
    </dbReference>
    <dbReference type="GeneID" id="119739732"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36629" checksum="719DC2B41001FCD4" modified="2023-02-22" version="1">MSFAEQIQAMMPDLVNGKTHQQVEEKLAALDRMLGSHVVNGFKFPASVQPSNLEALKAFEVRDDDVYVFTYPRSGTHWVGEIMQYILHDGKGDYDRTFMTNGLEMTIAEDPTQLEGVTPGYKTYAAMASPRCIVSHCLESFLPPQIFAKRGKVIYVARNPKDVLVSVYNLVAEQLDFDEMFFGFVQGKVVMGSCFDHVLSYWNHRDKENFLFIKYEDLHKDLRGSICKLAKHVGKDLPDDVIDDIVERVTFVGMQKTYQQIEEEHGKEGKLMTRFLGVTPYLRKGKVGNWKNTFTVAQSALFDKIYALRMKGTGLDFDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B470</accession>
    <name>A0A914B470_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071091.1">
        <property type="nucleotide sequence ID" value="XM_038215163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B470"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215163.1">
        <property type="protein sequence ID" value="XP_038071091.1"/>
        <property type="gene ID" value="LOC119739987"/>
    </dbReference>
    <dbReference type="GeneID" id="119739987"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="491" mass="52664" checksum="018E2335B8A35CBC" modified="2023-02-22" version="1">MAGSGRTSVGARVQDQPSRWGIIVVVAAHMNLALVESCLRTCSVFYLNWRSEFDTNAKETAAISSIMTSVSCFSMFFAGVLIQRCGCKLVGITGGVLTTLGMLGSVWVQTISQLYLTAVVAGVGLGITTNTALVAVALHFKKGYKTANALAYSGCGTGKMAAPPLIQLVLDSFGLRGAVLIVSAIMANIVVFSALFRKPRTDWKSGPDHRAIIDQLTERQEADFQTVHANGLAEMASESDGTSDDSDATVNHETHAEEGQSNVYTTHNISRHASKLKLNPIRKMWSRLGLSVFRKSYRFSLLCLLAFISTIPYFGADLFIIPRAESIGVALSSAAFLLSLNGIGGLLGRLVNGLFISCKLSAEIVCSICAAGAGVSVLLLNADNYVCLSVASFLLGLFTGVFYAVAIVLIRRYVGCKRFSVCLGIYYAFVGAGGLFGPVAAGWVFDISYSYKTVFYVLAGVDFICCILMFLFPVLKRVEPGIDDHQTNEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B551</accession>
    <name>A0A914B551_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071069.1">
        <property type="nucleotide sequence ID" value="XM_038215141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B551"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215141.1">
        <property type="protein sequence ID" value="XP_038071069.1"/>
        <property type="gene ID" value="LOC119739974"/>
    </dbReference>
    <dbReference type="GeneID" id="119739974"/>
    <dbReference type="OMA" id="FMLNFTN"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24044">
        <property type="entry name" value="ASKHA_NBD_NTPDase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="629" mass="68143" checksum="7E00069BA9E23D42" modified="2023-02-22" version="1">MQITVKAAIGAEVTSVPIEVEPSWMIQSVITEFCQRIDIPMTGNVQMKDDSGLMLNKHASIGEAGIHNGDTVFISHSDPESDDEAIDVRPGRSMEKPGMSNILMLFVGFVLVTGSICGIIALAMRFTEEICTDEGYGAVFDAGSSHTNLTIYSWPGDTKTDGTGIVKQEGTCRASGGGISSYDDNPQDAGPSLVSCLDDAKQVVPKQHYNLTSLHLGATAGMRLLEKAEPSTSALIMESVRQTMASYPFNFHPDQATIISGSEEGSYGWVSANFLSGTLNPSSTLSSAITAAFSSDPPSTFGALDLGGASTQITFIPQDPSSIPPQYAETFMLYGVNYTMYTHSYLCYGVNEAIRRFKATLVKDSGYADITDNPCAPKGFKEPVDSKYLWEVPCSSGPQALEGWGSELTPPASAQNTTFQLNGTGDLDQCQTAVGKLFNFTTPCLIEPCSFNGVYQPKPFGQFLAFSTYEKLISGLGLPKNATILQIQSTMKSFCAKTYDEIKKMSGNTQFLVLYCFEINFVLTLLREGYHFDTDTWKISFTGEVRGQELGWSLGFMINATNMIPSEAACTEFTRSGFYIGIAILIAAFVIGFILLVCGIYRCTRPKQQGGYEELNPDFAHGGHKYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7I9</accession>
    <name>A0A914B7I9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072146.1">
        <property type="nucleotide sequence ID" value="XM_038216218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7I9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216218.1">
        <property type="protein sequence ID" value="XP_038072146.1"/>
        <property type="gene ID" value="LOC119740792"/>
    </dbReference>
    <dbReference type="GeneID" id="119740792"/>
    <dbReference type="OMA" id="EVKRKWH"/>
    <dbReference type="OrthoDB" id="6117994at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="413" mass="46004" checksum="01D746489429A24D" modified="2023-02-22" version="1">MEARAAKRKPNWTDTEQIIMLDAYAKYKEVLACHVISCHEKNKCWFEITKQLNLRNSSVQRSIEEVKRKWHNLLGQGRRDFYDWKQACQNPNMVPGPSPMPAISRRVLELHGGFILEEWKERLEPGSAQTASHQDEEEFIYVEASSPDMSEDQGTYECLDSPDIAEPEIKALASDPVKRECPSPQVLVMSDSSEASAHQTSAALSATSPISTAFHTSTTSNLHISTPPYPTQPPNPASLTFNTVQSTQITDAQTNGSRNQANSVSPLLNQTPQNPSPRHITPPTLVSMATISNISSSVGPTRQPPSLFGPTTNPQSSYLSSLFSPTTNPQSSYPSSLFSPTTNPQPSEPPRKKVRVSESGVSERGAGLHVEREAELRLDILQLEKDKLWLETEKLRLEIDILRKKKQQMNSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B938</accession>
    <name>A0A914B938_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Direct IAP-binding protein with low pI</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Smac/DIABLO protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072641.1">
        <property type="nucleotide sequence ID" value="XM_038216713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B938"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216713.1">
        <property type="protein sequence ID" value="XP_038072641.1"/>
        <property type="gene ID" value="LOC119741064"/>
    </dbReference>
    <dbReference type="GeneID" id="119741064"/>
    <dbReference type="OMA" id="PGNQKFG"/>
    <dbReference type="OrthoDB" id="6153032at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009062">
        <property type="entry name" value="Smac/DIABLO-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015142">
        <property type="entry name" value="Smac_DIABLO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247">
        <property type="entry name" value="DIABLO HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247:SF3">
        <property type="entry name" value="DIABLO IAP-BINDING MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09057">
        <property type="entry name" value="Smac_DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46984">
        <property type="entry name" value="Smac/diablo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="267" mass="29435" checksum="743E82C9F31E8C34" modified="2023-02-22" version="1">MEPLLSLCRSKLSKGMVWRCSKQLQFCERWRWLFQSVLNRHRPVQLSPNRGLWSLRILTRPLYRSWFVGLCGLSGGGVLLSAMPCVPVGSNEKPSAQSTSASLQSNAGSLTHRELIKNAAAIAVDSSCILLTHAALAAISLHKEYSEMVNILRLLLEEHAQFVGPPSQEDDLWQDIIRQRVEIEDNIRAIEDANVMLTSAILVVERAAEAAYQADAELSALTAGQHLQLVQAQLGAARKVSQKAKEELTNIQAQTIKKEGDGEQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA81</accession>
    <name>A0A914BA81_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038072909.1">
        <property type="nucleotide sequence ID" value="XM_038216981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216981.1">
        <property type="protein sequence ID" value="XP_038072909.1"/>
        <property type="gene ID" value="LOC119741238"/>
    </dbReference>
    <dbReference type="GeneID" id="119741238"/>
    <dbReference type="CTD" id="22933"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="420" mass="46295" checksum="3B15CB9E50DD48E8" modified="2023-02-22" version="1">MPVLIPIDESGRSLVIKMSSEGSKDQASGSDGSGGGGASKGKVGGSSSDGEQQHSGFNPMETLEQLMRLLRPWQQADEDEEAAAKPEQLLEDVTLEGVVKYMQSNKCKNIIVMTGAGISTSAGIPDFRSPGTGLYDNLEKYNLPEPMAIFDIHYFMERPEPFFYLAKELYPGKFRPTPSHYFIRLLADKKILLRNYTQNIDTLERIAGVPGDLMVEAHGTFHTGHCIGKCGKEYTQQWMKDEIFADRLPKCTECEGLVKPDIVFFGESLPMRFSKLVMEDFPKCDLLIVMGTSLVVHPFASLIERVPVTTPRLLINKEKAGEGIPRLRQLGMDAGGFDFESKDKYRDVAYLGTCDDGCYKLAEMLGWKDDLDKLIKSGHEQIDGQSAASQPSKKPSEGETDQAEPSTKAESPSKAEAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB15</accession>
    <name>A0A914BB15_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NXPE C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NXPE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073030.1">
        <property type="nucleotide sequence ID" value="XM_038217102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217102.1">
        <property type="protein sequence ID" value="XP_038073030.1"/>
        <property type="gene ID" value="LOC119741353"/>
    </dbReference>
    <dbReference type="GeneID" id="119741353"/>
    <dbReference type="OrthoDB" id="2112051at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="3">
        <location>
            <begin position="328"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="558" mass="63936" checksum="59AB1E9BDDD06F88" modified="2023-02-22" version="1">MRRFRISLPRLVLIALPVIMCVVVILGYAALSAKFRTTVRDTTEHIQTVNLKHDVRVVTPAAWPRFNAIPTARNTKYIAHEVPGPVEKGLPGRWQHRRGNLGMTSSKTSTISLTSPANVTEGEMFRVMIEARDTSNRSRTMGGDFWYATLATKGGGSTSGRVLDHANGSYSVYFFAGWSGKASIQITMVHPSEAVDYLVQTVWHAYDRINWLGRFEDGVNKSTTPCVLRRGGPWTGKCELSHPYALGKTVLLCDEPAHGLKCDSLVAVYNNNTWIRERARELTKGREQLFQGKAKDSRKDLLLKQLPECEPDQPKPLSAGYWRDSRTWVSLACRTKEWKVPRDIGRCLVNKMVYLLGDSTSRQWYELLSGMLGVPFVRKDLLEQNNIYRHFDEFNLTTIFKFHPLCLTRNPRPTPFNLFSFEVDVLDALKDRSCNYVILISPWAHYPQWTKDMFLERVSLLREALLRFRARCPDAPVVVKGSHPRDQPGLEGRIFYNNFMLYQLGKILRETFQGTAAWFLDIWDLNMAYPASKMVHMPDDVVKQELSMFLSYVCRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBB0</accession>
    <name>A0A914BBB0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073503.1">
        <property type="nucleotide sequence ID" value="XM_038217575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBB0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217575.1">
        <property type="protein sequence ID" value="XP_038073503.1"/>
        <property type="gene ID" value="LOC119741710"/>
    </dbReference>
    <dbReference type="GeneID" id="119741710"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037470803" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="170" mass="18871" checksum="7FDA792413BB73CF" modified="2023-02-22" version="1">MFTLLALFSLAFLGSANGNWPVGNDDSYEGLKFYEMNLECNDALSECEHRFSGHFSPVKGLPLTTDHVLEYTKDPYELKFGAKVATLGLKVRFDQDDPSETFHFCSELTEDKALPVIGLYHGKWTLCLENDFSGLTIPADCTAPVAVSKIVGRFTDEKLAGQQVLYCMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBY4</accession>
    <name>A0A914BBY4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072942.1">
        <property type="nucleotide sequence ID" value="XM_038217014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217014.1">
        <property type="protein sequence ID" value="XP_038072942.1"/>
        <property type="gene ID" value="LOC119741263"/>
    </dbReference>
    <dbReference type="GeneID" id="119741263"/>
    <dbReference type="OrthoDB" id="5989392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="443" mass="47504" checksum="1DB759119DFA0D38" modified="2023-02-22" version="1">MDQLPKFRRLSNGTLMLGYSAAAQQVQAANKGKPITPCLSAAVVKQKASEQVKHFGGNPQDTMSLLGQYQIQFGAFRGQTFKWMLENGLGYCGWMADSMRGERPTDAPLSKNKFAFKLYLETFAEGKEVIAKKKAERLQKAGQVMQSSPPPSTLIPPATSLSSLMVGKLTPQRVKKKVQSSLDSPKGTISNRVIKCTLCSSVNTVGLHFTVTKKTEAVPVMRSSPPPSASRAPAASRAPAASTSTMKDEKSTPQRMKKTVQTSLVSPKEAILKKTAEAGQLMQSSPPTSAFRAPTASTSTQRGKKTVQTSLVSPKAIVKKKAEAGPVVQSMPAAPSTFRAPAASTSTLMDATPQRMKKMVQTSLVSAKDKSPIATDDVSDEELLRAVSDVEATLQKDYAPADTEGSSTSTKSLQSPAGTRDHSDAQYKSKLSTVLSNRRQVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCM6</accession>
    <name>A0A914BCM6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073595.1">
        <property type="nucleotide sequence ID" value="XM_038217667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217667.1">
        <property type="protein sequence ID" value="XP_038073595.1"/>
        <property type="gene ID" value="LOC119741770"/>
    </dbReference>
    <dbReference type="GeneID" id="119741770"/>
    <dbReference type="OMA" id="RSMAYRI"/>
    <dbReference type="OrthoDB" id="7744248at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24512" checksum="EF31A5FCF4AF65F0" modified="2023-02-22" version="1">MAATGRYRRISDVDRNRLIDAFEADDADYLQVADTLGIKHSTARSIVGVYLRDGRRNKLPKGGPINQKVDDDMRDALQGYLDDNPLLTLRQLNTQLRADLPDKPFVTTSTIARTLDGMLITLKLAEDVPEQRNEPRILDARVIFGNWFLQVGVLGHTVYIDETGYNIWTRRSYGRAPRGEPARRVVHGQRGKQVNITFAISGEVGQNIIRDCDESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCW2</accession>
    <name>A0A914BCW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074073.1">
        <property type="nucleotide sequence ID" value="XM_038218145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218145.1">
        <property type="protein sequence ID" value="XP_038074073.1"/>
        <property type="gene ID" value="LOC119742110"/>
    </dbReference>
    <dbReference type="GeneID" id="119742110"/>
    <dbReference type="OMA" id="IVCEVEH"/>
    <dbReference type="OrthoDB" id="3156061at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002737">
        <property type="entry name" value="AGAP008430-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000051">
        <property type="entry name" value="zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="399" mass="44860" checksum="258D7313FBE734AF" modified="2023-02-22" version="1">MDTQGPDLNCHLRVHTDEKPFVCATCGKAFTTESDLQRHNRIHTTEKPYACEICGKAFAQQAKLCTHERIHKGQRPFPCATCGKAFARQGGLRVHDRVHTGEKPFVCADCGKSFATKGSLQRHERIHTGEKPFVCVTCGKAFTTKLNLHLHDLMHIGEKPFGCKTCGKAFTTEGSLQRHERIHTGEKPFVCETCGKAFTTHSHLRQHEMIHTGEKPFVCATCGKAFTRQSDLQAHQRIHTGDKPFCCETCGKAFTWQSDLSKHRRIHTDEKPFACETCGKAFTRPSGLRDHQRLHTGEKPFVCDTCGKAFTRQADLHKHDRVHTGEKPFVCAACGKTFTQRAYLYTHGRIHTGERPFVCGTCGKTFTRQCGLYRHERIHTGQKPFVSETSGNAFSSTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD51</accession>
    <name>A0A914BD51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074163.1">
        <property type="nucleotide sequence ID" value="XM_038218235.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074164.1">
        <property type="nucleotide sequence ID" value="XM_038218236.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074165.1">
        <property type="nucleotide sequence ID" value="XM_038218237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218235.1">
        <property type="protein sequence ID" value="XP_038074163.1"/>
        <property type="gene ID" value="LOC119742196"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218236.1">
        <property type="protein sequence ID" value="XP_038074164.1"/>
        <property type="gene ID" value="LOC119742196"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218237.1">
        <property type="protein sequence ID" value="XP_038074165.1"/>
        <property type="gene ID" value="LOC119742196"/>
    </dbReference>
    <dbReference type="GeneID" id="119742196"/>
    <dbReference type="OMA" id="CNCKIAP"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="395" mass="43601" checksum="32E1CEECB0B9DF7B" modified="2023-02-22" version="1">MTMTTDTFAMTTDMMSTMTPDSETVFISVSANSPDSFMTSDTFPHENITIASVIASTTEGPLQGFRFEDYTQRAIMATIICLVSVVGFVGNVMVLLAVNLSRKLQTRTNVFVVNLAVADLLTCFCAPFVAVALFSMSGWPMPEIVCSNIAAFGFIGLACSIMTLASISINRYVLITKTIATYRSIYTPKKIAAMVVFTWGYPALVVCCLPILGVGKLGYSDKYKTCTQDTSHETSDLFSSLSSALIYPIPLIVLFVCYFKIYRHITGHMKKMMGKGKGVEMTDTSHFSTAASTTQLHKNPPASFSKRQVEITKNLFYVVCAFVACLAPFAIALMIPPSDPVIPWTGMIIIFNSAVNPIIYGAKHPHFKEVFRHMLRCRYHMIPEPSGCLRKIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFB2</accession>
    <name>A0A914BFB2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074127.1">
        <property type="nucleotide sequence ID" value="XM_038218199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFB2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218199.1">
        <property type="protein sequence ID" value="XP_038074127.1"/>
        <property type="gene ID" value="LOC119742160"/>
    </dbReference>
    <dbReference type="GeneID" id="119742160"/>
    <dbReference type="OrthoDB" id="10683182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037702879" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="590" mass="63232" checksum="C87E4100299D9389" modified="2023-02-22" version="1">MDLTLVCLLLCWYSHRVSALLPPIQVTTAISQPADAEPTEGDTVTLACNASGLLESYAYTFDWHRHVMGTTWEPVTTNGIVLNARYFAFIIGDPPATTTAILIVRNVTRDDRLFECRVSQNGNQVSAPYPILTVRYFPSDLYPICAPSGSFTVPEGATLLMNCTTEPGYPLVWVEIIQSTVGVTWSEITGDEIELVLSSQLSVSADHQDATFTFNVTSASAFPGRASSCSIGPLHVLRMETPGVSSYPDAPTAEPGPTNNNARTENPKVPTQPDAPTTAESGPTNGVFQTTPDSQTDAAPVAWIVVSVVLLILLAVSVPINAVFITRCWRHRRSKTSHPQVPDVELEPGGKDTNAYLVPTNEEATGEAVYQTVLETKEPEYTYVASDENIEKISGHATVDQSVSKTEGAKYTYVASDENIGKKSGPATVDQSVSKTKGAEYTDVASDETTGKKSGLATVNQSVSETEGAEYTYVASDETIGKTSGPATVDQSVSETEEAEYTDVVSNETVGKTPGSATFDQSVSETEEAEYTDVVSNETVGKTPGSATFDQSVSETEEAEYTDVVSNENTGKTSGPTPDEKHYQNVKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFP2</accession>
    <name>A0A914BFP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074680.1">
        <property type="nucleotide sequence ID" value="XM_038218752.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074681.1">
        <property type="nucleotide sequence ID" value="XM_038218753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218752.1">
        <property type="protein sequence ID" value="XP_038074680.1"/>
        <property type="gene ID" value="LOC119742626"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218753.1">
        <property type="protein sequence ID" value="XP_038074681.1"/>
        <property type="gene ID" value="LOC119742626"/>
    </dbReference>
    <dbReference type="GeneID" id="119742626"/>
    <dbReference type="OMA" id="IKENACM"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF519">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="243" mass="26285" checksum="D77BD145692E6002" modified="2023-02-22" version="1">MVEGCAKCIKYLVFIFNLLFFISGCAILALGIVLHVKEGGFATLIPDLPFLNAANVCIAAGIIVMFVAFLGCCGAIKESACLLLLFFIFLLLIFLLEVVAGIVGFIYKGQVETVVTDDLANGMKNYGKDGQAGLTSGWDRLQTEFECCGVNGISDWSTNHDSYILNSTPDSCCVEALRTDRCGINPTFIGKYSKGCKEALIKKLEDSIYYIAAGGIAIGLFQILGMVFAMVLYCNIKRENAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGI5</accession>
    <name>A0A914BGI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein unc-79 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075209.1">
        <property type="nucleotide sequence ID" value="XM_038219281.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219281.1">
        <property type="protein sequence ID" value="XP_038075209.1"/>
        <property type="gene ID" value="LOC119742985"/>
    </dbReference>
    <dbReference type="GeneID" id="119742985"/>
    <dbReference type="CTD" id="57578"/>
    <dbReference type="OMA" id="GKERRWM"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2444" mass="273061" checksum="299373FB3E9852B8" modified="2023-02-22" version="1">MSTKSEQFSAKIRNLTDYQNRILHNIAPLPTGTDIANTLRYFIHTLRSILKEAPADLGDLKQSARRRLNPRLPHYPSLDYLCLYETLDSLIEIVPSVQYGQSDLGQAIQQLFGCILWFLEPEIVDTIPHTVASTLAIFPTALQKETVDLLCTTLLPICLSEVQSIEGDTYAEMSVSAVIMLVLQHCKNKAHHAQLMECIMTYKKDIFKDILCTIAFGPSSARGAASNLLFHYWPSLVPANVEDRDFSYTCWKPIMCQRSNCLSPVNNAAVKMCMDPVIAGKYSKHPPPLYLCQVCSDYVNREMSDCKPFLNVLQPQEVVSKICENKNCSSPDKTALFTCYSSECTGYKGNRPIRYCTSCNTYIHSDRKEHIMQDFPQDPLSCDKETQSYLCEAIISLLKEAHVVEKDPLMAAAEAETTTDNYSQPSENEVVDLEGVEGDSRLLSRFGLWLLIEKCNPTDRTPDEVVGRLLSMAFQWFGFTATLTQDSVALESLKADYVTTWLMKILKSHFTVFVSCLLPLPPDYARVGGDYDSLCSRITELLGGLRKVFSLTPYNAITFEVWDYIMPHWMECICSDIPDEELPQLQDVLCRLFDVDMSPLPFSTEKLFNFVACRFRGMAANDQEKALLWLQILTETDIVIPLKLLLSIFSDGLTSMSKIQVAKQKLKNQQQQASSEPSEAPADTAHQQHQQQQPCDEVTIEAPPADPPSATPPPAAGPPTGGPPEGGVVMGGVPVEPPHVTIDPSPDDGPMQEQDEEQILRCFVLMLDMLVIQVDLQYLPFHQGMENSQSKDFVSLLTQTLSMTWLDPHQCTNHRSGKFQPHGQQPRALGACSTCDLWGIYFQLSLKLLEHISPVSETKVCDMPEVSEYQFEKFLEDGLAKAKALNNDVKGKKNRMAERGSSKQKRFTKTKDPGKGFLSATEMKPVEVFTAETVKLPSAKDLKAEKEKAVKKATAGDKTSKGKKDGDNGSQKEARFKLEELPKSIQLLYVLLKEVPRQRDPDVLLNLFNCIKILCLNAECLRQAAKDHDAFLKYAQNKLLIPSFWNLLKGELSHVNELLVPLFLHSLALPHGSDAMWNLLQRDVENEDWKARFCAVERVTALLRFVEKKSLGNNSVIMCSLACAFSTLVSASDDICPAVSSRAMIMLETVPKKVLKVLVGCLEFQWDCVVEDRVMILNALYKLQHFLPDMMILSWEFFMNRLDTLALEAQVEMEHNKEFPFPIDLSRSQAGVVDRMDTFLNKQTRARVARSQSEMNSSLKPRRLSSFNMKTNFKRRSMSSPATANGFSRIYFASTNRSTYSRLSESSESESAGPLGESLFENGHLQTVQEEQQQPDMPTCALDLSSLDKETVHKLISLLMKFMTRDSSADEEQTSGRAMNSVKGRNMMRKSTVLRHLSVLMGYNQVEKCFILAPQQLRESAVFYAFMAGAPKMLDHNVKVGNVLLPMIMELFAYCPSPQKSPQDMQPHDYTLWFLEPHCRHSWLLSVLIILYKYNFDQLELKAEVKSLMRITINTLEAQRHQCKPKRPEPPTPEDIWGATTSLEKKRSESSLIQAMGENEEQENGEEVSSNASAGPSSPLLPVAPREIPAGLHQQVECEPDMLFVPEEEVTALTIKKSNLSFVASTIVEVEEENEESVEALEPLNKVEAIPAKALMVSKEEPVSAQAVPRVVTEMAKVERQALEPTLMSAKVESFFSPFEKSKLQPRFRSKKQRKMGVATISSNALSQRIDNKLGGGGGGGKQGDLNLDLSAAGGGVNAGITKGGMTRKSKEKGKKRSQKLKDQAQKTPEKNSSVYSAAKRYHEDKNFMALTRCTDCGVLLEEYDDDTVSLAIVVLSTLVHRDPELAAPLLLEMLQVVARIASGIFSPWQAESIGSPPGHCCTVAKQFLRCTLHQLAPNGVFPQLFLSKIEDGDFLKTMAVALTDFSDLSPMDAVSFLLEGLNEKKTLPSLRILLVLMNLAEYMENLPLEGSTAWGNLIPLFETFFRKLVFAMPENCDTNDLFRIMTVILKSPATKTLGTLLDPMTKLIGFVLQKCHFKLKLLIEICSLCNRIFVKERERQSLARCIVMEFVSALKFKSSLPDINLIQLVQFICLDAGGKMSDFGNLVGDADISEACIAELSSSGLTVDCMKQYLNDAIEYVGDLHTLTKVKDKMKGGSHQNLNEDTLGSQLKAGVAQIIALEFTRSSQRDASKAVNRYLPWLYHPPSAVQQGPKEFIDCIAHVRLLSWLLLGSLTHAAVCPINSSVTGIVCHPIPLEAGNHIADHVQVILAGFAEQSKASVLHMSSLFHAFILCQLWTMYCEQMASINAPQSDQHNTAMMSVMDFWGRVTPGVLQLLSHSKVLADMVNLHFLSLMEALQECNSSVLTKLFPMWASILFSYPSKLPGSLQVRLQNCENWAPPSLTKGEVTTYHSSVLLKWLKRLQFKMGQIEIQSSAAAQFYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH76</accession>
    <name>A0A914BH76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075618.1">
        <property type="nucleotide sequence ID" value="XM_038219690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219690.1">
        <property type="protein sequence ID" value="XP_038075618.1"/>
        <property type="gene ID" value="LOC119743287"/>
    </dbReference>
    <dbReference type="GeneID" id="119743287"/>
    <dbReference type="OMA" id="CLWSCWK"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="34"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="221" mass="25097" checksum="A81FE4558F8514CA" modified="2023-02-22" version="1">MLPANLVLHLTAKLNVNVNPTFPNHLLLFPYHLVVELIYWRDPKKTAPVFASVLLVLLALSMCSFISVVAYLLLAVMTVTISFRVYKTVMQAVQKTGEGNPFKAYLDQDMTLSKAQIEKYTDKVIDHINAHSGCLRHLLLVEDLVDSIKFAVVLWLLTYVGAWFNGLTLVMLAWIDLFTLPIVYEKYQVQIDEAVGKAHTQINTVIANIKTKIPWLKKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIF6</accession>
    <name>A0A914BIF6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075631.1">
        <property type="nucleotide sequence ID" value="XM_038219703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219703.1">
        <property type="protein sequence ID" value="XP_038075631.1"/>
        <property type="gene ID" value="LOC119743300"/>
    </dbReference>
    <dbReference type="GeneID" id="119743300"/>
    <dbReference type="OMA" id="YQAHAIS"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000030">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="43"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="257"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="406" mass="46254" checksum="DA4048F6DDE8A94A" modified="2023-02-22" version="1">MPENNIVHDSQHTSTTLIRNCSIKLYTPRGSWDAKPMSGNYEKDIVASLLNNYGSRVIRPLRNSSQPVDVTLRLLISQIVDFDEPRQQLTVNAWQKMSWRDDFLVWNPNDFGGQDTVYVLESDIWIPRVVLLENVHYEFPSVDEKELIVSSDGTVVWYASAMFQFSCKVYVKRFPFDVQHCNMTLMAWSYDISALNLSYFDDEDTKQYIFSKNGVWNLTGVEMTRVETKYACCEHPFPQIIYRLTFQRASLVYIFSILIPSILLAMLTLMVFCIPPESGEKISLGITNLLAFVLFQQLISGSMPPIGDETPILTIYIFSMVVIGCASIFVSVYVLWLFHSPPERTVTRRLVSAMTYFSHDPSKSRVTWKAVACKLDRALLVLFLVLTLIVILASCIALAVAKDGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIW5</accession>
    <name>A0A914BIW5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076228.1">
        <property type="nucleotide sequence ID" value="XM_038220300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIW5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220300.1">
        <property type="protein sequence ID" value="XP_038076228.1"/>
        <property type="gene ID" value="LOC119744391"/>
    </dbReference>
    <dbReference type="GeneID" id="119744391"/>
    <dbReference type="OMA" id="YHAEDKD"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07864">
        <property type="entry name" value="STKc_CDK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000102">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000074">
        <property type="entry name" value="cyclin-dependent kinase 12 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="480"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="832"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="954"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1148"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1258" mass="138343" checksum="8F71C70B11A8C83C" modified="2023-02-22" version="1">MPGPRQPSSRGRAFREESPPNSNRARKHKKATRHKHKRSRERDRREQAPKVKPLVEYDDISSDEEVYLSPSPPPVQFVSETKPPTKSQRTKSQRAVSPATALKEYRNRQEERNSPQIHARSSSSNRPSRQPYVPAEAPKAYRRQSPTNPPRAYRGSPDTIRVVERKRSRSPRRKSPSPARKRRAEKTQRSRRSPSPSPSRRRRSSRSSSRSPSYSRKRSRRSRSRSRSPYRSRSRSSSRSFQRRRSRSRSFDFSTARFKMGLGSELKKNTKKLVESKTVDPSTGKGIPPTRKALVQEAQSPATPSPSSLPTTITKPYSGSPIKVTIKNEAALNRAKAEESPQRTVMEVPGNRNQPFQNLLIRKEVKPEVKKESPLPAPVTKPTPQVTTLPPLPLPPMIDEKHSSTPPLPSKEEKYRPSIKDLPLPPSAPKSAAVPSPLLAPTVPFTPSKPTSQKRERIKRRRVEQMASGLNWGKRCVDVFDIVDQVGEGTYGQVYKAKDKQTGELVALKKVRTDNEKEGFPITAVREIKILRQLNHPSVVNLREIVTDKQDALDFRKDKGAFYLVFEYMDHDLMGLLESGLVSFTEEHIRSFMKQLLDGLSYCHNRNFLHRDIKCSNILLNNKGQIKLADFGLARLYHADDKSRPYTNKVITLWYRPPELLLGEERYGPAVDVWSCGCILGELFTRKPIFQANQEIAQLELISRICGTPTPAVWPDVIRLPLFNTIKPKKNYNRKLRDEFALLPKPALDLLDKMLTLDPEKRISATDALNCNWLKTVDPGKINSPNLPCGQDCHELWSKRRRRLEKQQAAQNQSSASKRKEVGLGLVSDENVKIPGISGDGESASRSGGSKGGRSVPSDGEPEAQDSASGSKSSEKQLAGLVSLLQSQSGLDVNKLAEALNVKVDRSTIKLLENLNMQLLLAAAATNQSKGGSTSRAKDDNLVSTASALLALSKGNAESKGETSGSGAASVDPKTKDRPQEIPSTLTDYVSSLFGKSTAPANTVATGSAGTSTSGSAASSVGQPVAEGGMDSGPYRPTGSRGSSYNSPANKNYGEYDYEPHDSYNAGYQQRGPSTPPLDAAMGDGSRGDGEGWKPPTPLGPPPDSPEMEQDSQPEETTLVTPGVKAALMQMLKAQGLPELGLTNQGSNEVTPTLSEHPLEPQGTAPVPPDCYGNNTHVDSPGYPENSNFNSRLPGNNNVPQDYRGYRQDVHQEGDRGRGWGGGTGNGAPRGNQGGQFGAESFSRSRGGAGFDQGASWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJC1</accession>
    <name>A0A914BJC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metalloendopeptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038075926.1">
        <property type="nucleotide sequence ID" value="XM_038219998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219998.1">
        <property type="protein sequence ID" value="XP_038075926.1"/>
        <property type="gene ID" value="LOC119743577"/>
    </dbReference>
    <dbReference type="GeneID" id="119743577"/>
    <dbReference type="OMA" id="WVISSPV"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018996">
        <property type="term" value="P:molting cycle, collagen and cuticulin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000028">
        <property type="entry name" value="Zinc metalloproteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017050">
        <property type="entry name" value="Metallopeptidase_nem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036365">
        <property type="entry name" value="Astacin_nematoda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="108"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="354"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="467" mass="51970" checksum="A29E91575D734EB8" modified="2023-02-22" version="1">MGVIWENVRPLLRCVSIIVNVLVLMGVGLSQARPSTTPMESSDLTTAPNLSKTPLAVSMEPKEEEPSPGAVQSDMMLTAAQLTLLREAEADERRAIRPTNGRRRRRRKAVSDVARLWPRGIIPYEISLSSMSDRTIIEDAIAHWEDKTCLDFRPFNRRLMRDLRHTSKIVFFKGSGCWSSVGRSHSGAQSISIGEGCAVLGSIVHEIGHAIGFFHEHSRPDRADHIRVHTENIHPRYHQDFRALSWGRVATMDVPYDTKSIMHYGSHYQSMNGEATITTIDPLQQANLGRKDALSFGDAKLANIIYQCNAHCDITTAETECLNGGYIGPSCGCVCPDEYSGQNCSVYTPKLTGCVRVLTEERGVVSSPNFPAAYENDMHCIWQIKGSANSTIQVNVLSFSMEGGDGCPYDYFRYLQSDMRPLGPRYCGETSPPTNVTFPINEIVVEFQSDGEINDNGFQFEYLFVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMM5</accession>
    <name>A0A914BMM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077195.1">
        <property type="nucleotide sequence ID" value="XM_038221267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221267.1">
        <property type="protein sequence ID" value="XP_038077195.1"/>
        <property type="gene ID" value="LOC119745039"/>
    </dbReference>
    <dbReference type="GeneID" id="119745039"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037594223" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="168" mass="19521" checksum="506EE56138CA9E38" modified="2023-02-22" version="1">MCNHNMRNRIHLLFLLSVRIGVVTALCNICPFQWTPFGTNCYRLYKEGLSYDMAEQNCLDLSTYRKEAHLVSINSQEELDFITQLVSNVYRGQWKEIWIGMRLDSTAQTATWEDGSDPTAFSYWYGSTTTPVRYGYGDCTLYTISTDKWHPWWNCNANVPSVCKIDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNN5</accession>
    <name>A0A914BNN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077097.1">
        <property type="nucleotide sequence ID" value="XM_038221169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221169.1">
        <property type="protein sequence ID" value="XP_038077097.1"/>
        <property type="gene ID" value="LOC119744946"/>
    </dbReference>
    <dbReference type="GeneID" id="119744946"/>
    <dbReference type="OMA" id="FSNVKQM"/>
    <dbReference type="OrthoDB" id="6424969at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="255"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="48294" checksum="D58EC2FCE0DF4024" modified="2023-02-22" version="1">MASRSIKKKGFFQGMRKRSASFAHPGETGPKECSTDFQAYLKAIVESKATQHPETPPKNEDEEEQPQRRLRSYSDPSGGLSSHKTTPNPILKTIPETSPSKTRRSSLSQTQNLTSDFTFFEDEENEDDIWSSVESFDSGDVEIYSNSPRTRRHSCSEKNVRFGPVQMRDPPLNQGIEVFTWLPNGNRLTLTGQPGMKIKDLVADVTMEYQIPRHRLRRASTLGIVRDDARLSTLARQEIIIESRCVEETEEDADKRLAVLNEFISTERAYCNLLQSIFTTYKEPLRKSPSMPKSDHTRIFSNVKQMVTVSVTFLTKLEEVASSWDPNTSTIGDLFDEEFLEEFKEYYAHFRVMRLLLVFLQNNNKDFVHLCREKRGASWHTLDSLLLLPVSHRFKVAVQYGMSSHLSPTVHPTEACSLGLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQL0</accession>
    <name>A0A914BQL0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077941.1">
        <property type="nucleotide sequence ID" value="XM_038222013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQL0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222013.1">
        <property type="protein sequence ID" value="XP_038077941.1"/>
        <property type="gene ID" value="LOC119745566"/>
    </dbReference>
    <dbReference type="GeneID" id="119745566"/>
    <dbReference type="OMA" id="MLHNIHF"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="219"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="816" mass="93073" checksum="D5B30939134E6FE7" modified="2023-02-22" version="1">MDIGSLFGRDPLAVKFAAKLFGKKFARTNKFIHTNKLWMQTIPTRDCDVLMTFPAKTDDDTLMWLLSRLRARTPELGVHVRHHGNTGVYGFYLTARYSNLLKGAEDLGLRKPIKEEYGGGLKEFTCAEEGIFEGVDNKKEFFSSQQRQAIVHHMLLNLRAIEGDKLGKIKFLEAQAIVPKLLSKGIVTQVLPLHNSEALASLKTNWVQAVFRLQPIDDICAYFGVKIAMYFAWLGQYTKALIFPALLGAVLTFYTESNQESEDFNFVIFTMFNIIWATLYLESWKRKGAELAYHWGTLDSKHELIEDPRPLYTGDPQISPISGRLEPHFPAWKRNLFRYFVTLPIILLCLAITFGIILTLFELQEFVNRQIEKERFSGWVGVLPKILLALVIYVLEEFYKKIAHWLNDKENYRLQATFENHLIIKLVVVQFINNFLALFYIAFYLQDMKRLKQTLATTIITKQVIGNIKESLLPYVLEKLKVYQMTYKLVQGSVDMEDGADDEPKTEKPKTDKEDSGTDDVENLDAAPDDEQKELYHSKEPNEKFTLTQAEVESSMKTYDDTFEDYLEMFIQFGYVILFSSAFPLAAVCALINNVIEIRSDAFKLCSSMQRPFSQRVENIGTWQDAMEVMGVIGVLVNCALLGTTGQISRAFPGLAVAGVILVVMFLEHFILAIKFAIAYAIPDIPHWVSMEMAKLEYHRREALKKLELATLQSTKENLCRESSMSTTAATSENSRDAPQHQRVVEKPRSLPSEEPVKPKKQETSRVWPPAMADVAANYNVFKDLEKIRSPPTSPTEPDTPISLVTPKSDEEKKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BR53</accession>
    <name>A0A914BR53_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly [ADP-ribose] polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078445.1">
        <property type="nucleotide sequence ID" value="XM_038222517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BR53"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222517.1">
        <property type="protein sequence ID" value="XP_038078445.1"/>
        <property type="gene ID" value="LOC119745867"/>
    </dbReference>
    <dbReference type="GeneID" id="119745867"/>
    <dbReference type="OMA" id="NGENCSH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23466">
        <property type="entry name" value="WWE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="7">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="326"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="61128" checksum="7F508C58E0F92E62" modified="2023-02-22" version="1">MIGRLVCWLAIGFSGLYFLHLWRSSSKNKKPPKQTRALTSRDEHQSQVPPVSSWRPPATLWRPPATIDQHQSQVPPVSSWRPPATLWRPPVTIDQHQSQNPPVLSWRPPATTVRYDHGVLLKSFATTSNQICIFNLRGMCAFGNNCRELHSEQHYQWQYSADNGQTWTNFGDNVAIEETYCNIRMEGINIQELGVIRTLFFETMKWSQMDVRRLEIQLTNTSDLNSWQSVLATKWQWYFLDNGNIWMKYTNRINTKVEEAYQMFLSTGQDPTFEFWIVGSHRYMLYFQRMVQRNKNVGTVRKVRRRPKFVTEDMGESCLKLPKYWESNLASADPLSNFVRRKLDPRLHEEECRMVIGHFAKEIDANSFLAIKRVQNIELWREFSKRRDLMQDGQEDSSKAPVELMLFHGTEKQNIEAICQENFDPSLHGTNVGAKYGQGSYFSKSAKYSDAYASPDYKGRGHMFLVRVLVGSYTRGDPKYCWPPLKEPNGLFFDSCVDDPSNPKIFVIFDQNQVYPEYLITYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRM3</accession>
    <name>A0A914BRM3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078953.1">
        <property type="nucleotide sequence ID" value="XM_038223025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223025.1">
        <property type="protein sequence ID" value="XP_038078953.1"/>
        <property type="gene ID" value="LOC119746211"/>
    </dbReference>
    <dbReference type="GeneID" id="119746211"/>
    <dbReference type="OMA" id="ANHREAN"/>
    <dbReference type="OrthoDB" id="9901374at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="5">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110648" checksum="6E8238F8EA5CBFD7" modified="2023-02-22" version="1">MATESTTDKDKDTMSHSKGNTSIELIKEKMKEKRRKKALNDSNTSWSRSFSKRKGTTASYVLKASLRSNNQSLAKALAASKHDAQQAHQNILELQRDRQFLLQQANSKRMAEKECIQRFGNIKQVLSKVTHSLLDGVSSLGQAIDLCSSLPLRESSLGLIPRASLTSDDDSFRIVQKADQGSATYCRQAQLSSAIESAASHVMQAADTMATATINQSEPSSVRQSQNEQAQGTSTSEELKGSVQSEPVCDGTSQSASSLIGVPLSDKLKDLANEELDLEFPSLDDLDIPLRFIDETPDSKVSGSSNARRQSSRLEPPVKRSRTATLLTDPIAIQKALAEDADYTAYTEDPDENNQTVLSPEPEQGFRQTPSTTFLDPSPSINPKNQTVKSTNKRPAVKSRRATYNISPVRSEAAGNKTFEVSGSPQTPGVPDQQTTGVVKERYVFIHTPPGNVSNYKTMDMELTGVTNNSTSTQDEQNKSLANKSRFNHDEQVIRPWGNIHMDKPKNSPAAKVNKQKNKTKPPTNTSKSLLPKPQKKISKESGKILTGKGIKKAGSKKPSKKTCLMSESFRNDLAVFDLSAGDSFSLAPPIFNRVKSKTTDALAGFTGTNTARDAGSCFDDEKSTEIPIVYRCPEPMPQGEQLQPITDSKPNTDRDAGIHSDNEKSTAVPSVLRCSEPMPQGGQLQPFQQEELLDSFPLEEHLQAESLKLVESVKTNRGSKIKRKSKKAKSVESPGVDKMTGGVLKAKPNVAIVDSEVNDIFEGTCLAKMGNTQPTTSWQPAEDINDAIPVLTSNKPTKRRPTKEKKVKVKSSDPPKTEILIEDTKSAFMPKQHPHKTLSTDKAVPFVTFNLSSPAQMTNDDGDDILGDIDVPSRKKKSTSPSSSTVPISTSKMDTETRCSPPSMATKNNSQPPISIQPAMDKASSSRSRRGQKRMADALKEEPTAEMEEEGAGSQETGRTSRRAGRISYKEPSLRDKMRNDHSSHMGKKKATQKKVKKSKRAALETVTNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRR0</accession>
    <name>A0A914BRR0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078854.1">
        <property type="nucleotide sequence ID" value="XM_038222926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222926.1">
        <property type="protein sequence ID" value="XP_038078854.1"/>
        <property type="gene ID" value="LOC119746127"/>
    </dbReference>
    <dbReference type="GeneID" id="119746127"/>
    <dbReference type="OMA" id="VWIHPFV"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="285"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="599"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="689" mass="77605" checksum="5CDFAF08E67D98FE" modified="2023-02-22" version="1">MITKWRLIIRAVAVLLVCLIAARVFSGSLFTLNLKSMNSSPDSSAFSSPAIGKLIGVEATTGKISIQNHKGNTVLSGSLAASSPASVKGLECSAEGNALCYTWKAGIAEVKIELVDTNEARPFTCAHVQWESFVADTPLRDCYSLDGAHWYGAGERYRQVWPIEKMSGSSTMFASGDVYTNLQRYGSVVDRYWLSSRGVAIRVSHDTPLHISLNDNGDGMLCFKSTYDNSYYPNFTNNLHLLDYTVCTHDDVRLVHDAIWREIGPAGGKPTGLPDERMIRSPIWSTWARYKIFINDSVVNDYADEIIAHGFTNSQIEIDDGYSMKYGELDFDHTKFSDVKGTVRKLHDKGFRVTLWVIPFANIDTNAYQEGKEKGYWVTKRGQNEGVVKWWNGLGGMLDVTNPTAVDWFVARLKKLQQDTGIDSFKFDAGETNYLVDDFETYVPFVNPCEYTTLYAKMAARFGGQIEVRAAFENQNLPIFIRMMDKDSRWGWDNGLKTLITTALTFGLMGYPYILPDMIGGNSYESDSEFHGLEVPPRELFIRWLEITAFMPAMQFSISPWQYDDEVVTISKKWVTFHEDVITPKLLQIAREETIVKPGQPLIRPLWWIAPTDEDSLKMDTEFLVGDDLLVAPIVNNATYSRDVYLPPVDGLWTRMPQGDSVEGGQWLRNVPVPLDEVAYFILNKANSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0J8</accession>
    <name>A0A913Z0J8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044195.1">
        <property type="nucleotide sequence ID" value="XM_038188267.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038044196.1">
        <property type="nucleotide sequence ID" value="XM_038188268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0J8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188267.1">
        <property type="protein sequence ID" value="XP_038044195.1"/>
        <property type="gene ID" value="LOC119718847"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188268.1">
        <property type="protein sequence ID" value="XP_038044196.1"/>
        <property type="gene ID" value="LOC119718847"/>
    </dbReference>
    <dbReference type="GeneID" id="119718847"/>
    <dbReference type="OMA" id="SEGVYMR"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324059" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="441"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="825" mass="91367" checksum="5968B76491C41FB5" modified="2023-02-22" version="1">MASILRRVCLPLVVLLYLAAARVSSQRTIKVGTWLPGQRVCVATACAYTVDIALADCNGRQLTCLPLKFNQAVNMDMGQNSINRLPRGMLTGYLRLRSLDLTNNLISTIEDRAFNSLGTLKSLTLSFNRISRLGVGTFTGLRSIQNLYLQGNSIASIHVNSFTGLTEIRDLNLAGNRLVTLPDSVFSPMVNMRRLMLQENQLSTTNRFLTGLRSLVELDLDGNRFTTLPDLSGMRMLGDLEITDSSIRRIKNNSFAGCGRMKELILSSNSIDTIDILGFNGLRDLTDLHLSSNVLQTIPQTAFRQLIFVERLYLQNNLLKTLTANHFATLTRLLVLSLGNNQLTVFPPLPTLRSLTTLDLTSNQLSTFTKDMLLSLPLLNRLLLTNNPLQCDCRLKYLRQWFIDSGRRHRSFEIPQCELPALLSKTRLTAAPASGLLCSPPSVWARTESVSGLEGHNITLDCSGTGGFPSPSISWRSPDHQELLPDVLSGRYLVSDDGPMTVIRATMADTGLFTCVGSNPAGMATVAVALRVKKNPNLPIPTPAIGGTIPVTPAQVDPLTSPGVDRPITPYIDVVTSFNTPSEKLPPDVLPTSWEPGKPGWEEKPRLPGEQPPPSDDDLYWDETGCGTHPTKVAWGIFLTFFLTCILCTIFFWSWYHRLIPRIIGRSLNLRSLKSRRPMSRNIVPLRSRAARAYNQMQSEGIYMRPGSYSGSDDSRSSSGTFDPDSRYVITESAVDPETLVRRQLILDRLTLKPSVVSGADRHTYMNADVVLSESNYTALCTTKDANRSSVQPGTESNEEHSTKQFKHKSLAERSVDSRIYMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z227</accession>
    <name>A0A913Z227_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase LRSAM1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045752.1">
        <property type="nucleotide sequence ID" value="XM_038189824.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045753.1">
        <property type="nucleotide sequence ID" value="XM_038189825.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045754.1">
        <property type="nucleotide sequence ID" value="XM_038189826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z227"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189824.1">
        <property type="protein sequence ID" value="XP_038045752.1"/>
        <property type="gene ID" value="LOC119720219"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189825.1">
        <property type="protein sequence ID" value="XP_038045753.1"/>
        <property type="gene ID" value="LOC119720219"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189826.1">
        <property type="protein sequence ID" value="XP_038045754.1"/>
        <property type="gene ID" value="LOC119720219"/>
    </dbReference>
    <dbReference type="GeneID" id="119720219"/>
    <dbReference type="OMA" id="LWCSSEC"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16515">
        <property type="entry name" value="RING-HC_LRSAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="581"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="692"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="247"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="350"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="85444" checksum="DF37456225149D43" modified="2023-02-22" version="1">MNPVNGIHEIDMPKSKLLHRQSESARKRMEHCQYLATESPEPTYDLSRCELYEVPSGTFSMCKVLRKEALILSDNLLSSLSGGGNIKDLAMLRVLDLHSNKLSEIPDALTGISGLQVLNLDNNQLKKLPRDTGKLQALQTLTIKGNQVKELPGTICLMKSLRTLDISDNKIKDLPSKLCYIRTLETLSLDAKNMRHPIASICMQGTEAIMKSLCAECGTDYSPPSQHVLNVLDPPKVSPSEDKPSSLRSLEEEEANLSNSIMQYEKIQESKRLERMRLERELEEMEREQAQLVTQTDKRHLGLLKALEKEQADLDSGIKTLQERSDIEKQNLLSVLHDVERQSTDLVHQLLEMNEKARKKEALLDQLEKERMELDATFLVVSEEHDLLREKDILKFMQVIMKENFELDQLRNRYDKHKENIRKEAEDSENVAFNQLSSQLHAKQLNNDAIVANLMKAEEFQREAFEMLLLSKDAKHKRLTEEIYMLQQQLAEVTMAELEKQSVKAESTNIALEQKREDLAALLKQLMIEREDREEELKKRLLEMEQRREDDVQDYWLIQFQRLMDRKPQSLIDQENNLEFSVLEILNRSGADDYIPMFARHRVTIETMLQLTDNDLKEIGVHEVGLRRSILSNIANFTKERDNASLKAKEMESHVDVPRRDPTAPSIDEAGASAVAGAALVKEVTVRVNAECVICMENNSDVLFLNCGHVCCCGTCSGSLRLCPLCRSDIHTKINMQKSSQSVIGGCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4C8</accession>
    <name>A0A913Z4C8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase eta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038046639.1">
        <property type="nucleotide sequence ID" value="XM_038190711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4C8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190711.1">
        <property type="protein sequence ID" value="XP_038046639.1"/>
        <property type="gene ID" value="LOC119720850"/>
    </dbReference>
    <dbReference type="GeneID" id="119720850"/>
    <dbReference type="CTD" id="5429"/>
    <dbReference type="OMA" id="QYNTWQG"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000007">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000003">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="19">
        <location>
            <begin position="8"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="20">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="471"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="736"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="797" mass="86461" checksum="3F0E710019490F4B" modified="2023-02-22" version="1">MPSPERIVTLIDMDCFYVQVEQRRNPALKGQPCAVVQYNTWQGGGIIAVSYEARAHGVTRQMRGGLAKEKCPAIQLVQVPVNRGKADLTRYREAGAEVITVLTQFSNCVERASIDEAYVDLTEAVHSRMAEMGGESVSVDMLPNTHVAGWDGQQGAGLETSEGEDEGNGEENEGNGPSAAPLTAEDARRTGTFQWLDQVTDLENKRLAVASVIVEEMRAAVLEQTKFHCSAGISHNKVLAKLACGLHKPKQQTAVPKQSVELLFKTLPIKKIRNLGGKLGRSLTDDLGIEFMGDLCRYTEKQLQAKVGDKTGAWLYGLCRGIDDEPIKARLLPKSVGCGKNFRGKMALDTKQKVKHWISQLAEEVTERLVREQDLNNRMAKLLSVHVQQNCNPPTSLSRSCALHHIDAATIAKDVFMVIQSLNMAGNQQEAWVPAITSLGVSASKFSEIQTGKSGIKRLDTFLTSVARLSEDQPCTSSATEDDEDTDLDQPGKARPSAGIQQKGSDVASGSKDLPAARKYGIQAFFTPRKDDTNNSSSPVAEDKGHCKDTGDGTPRLESPRRGPKKGYVKKNREPFFRNYTQTVREGTEGDYRTHGVNRTSGENNEVFDRENVGLEGSCFGGATNTNSKLHSGTSSAAENGKGLMENQTLEKIEPLCMSECSASQAVMAEQGPSLMCNPSVQQPKASLNPTSDTSLTSDMIVCDKCNKSVSPWDYPEHLDYHFAVELQAEMRVATASAASSQRSPTHNTLGQNPSGPGKGGAGGVKRRSKSPRSSEGSKKPKTKAASGTLHSFFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4X0</accession>
    <name>A0A913Z4X0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046056.1">
        <property type="nucleotide sequence ID" value="XM_038190128.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190128.1">
        <property type="protein sequence ID" value="XP_038046056.1"/>
        <property type="gene ID" value="LOC119720457"/>
    </dbReference>
    <dbReference type="GeneID" id="119720457"/>
    <dbReference type="OMA" id="VECECAT"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF16">
        <property type="entry name" value="FIBRILLIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2124"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="16">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="15">
        <location>
            <begin position="154"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="17">
        <location>
            <begin position="313"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="679"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="818"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="862"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="904"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="946"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1030"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1070"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1238"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1280"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1326"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1368"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1456"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1499"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1658"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1698"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1737"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="13">
        <location>
            <begin position="1951"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2061"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1687"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1726"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1767"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2070"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2089"/>
            <end position="2098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2243" mass="242038" checksum="A44E91BF208E78B2" modified="2023-02-22" version="1">MVAPFWADVNGNRFTGVKNVFFQVYDSSGSTMLSTLSSIVSARYGSFTAAWALVITWRFVEAISPNKNTNSFQAVLVTDHTHGYVIFNYERCGMNWNENLLPNDNVIQGFTCGQSGNKFYLDIPSDLRFRPGNMVGNTGMYGRWVQQLDNLPDNFVNPRLYCRNWYSRQFVTMSTLFWWFQTAHTCPCSWMNAFLDPRWTHIGFNYFLPNSGSSSSVAAVCYARRFQFPNNAGLLCCYSTSTWSLLRGVRSAVVASVFEHYPVSPLFSTESFYNQRYDQEVLPRYYCCSASTLCHLYDDYRPAMGCWRYRPPFWFWFWGDPHIKSLDEVEYTFNGLGEYTVALIENDNGAQIFELQGRTQRATNAETGELTDATFYSGFAAEYPGEGRVEVKLNKRQKADDLITTVNGDVVTPTTAGLLIGNITVKRDASTNKVVTMFPGDIQFTVGVNNSIGDITVQFGQTYRGKTKGLLGVWDDDQSNDATRRDGTIQPATGDGGEMIERDFYNFAETWRITEENSLFYYVGDETWALSNNHSFQPSFYEDLVAAATPEKLTKAQELCGDNKMCLFDTLATDDESIGQSTVMLNEMNSASESAAKNFPPNITASDTFRVMVGVEFEEQLEAVDPDGDDVVFSLVEPIENASITEDGGLFKWTPMEKSKVMVGLLATDGQANATHEPVVQLCDCMNGGTCLWDEFVMGTDIVEDRFGVVLCECDPGWSGEFCEVDYDACEDGPCFMGVACFDEAPPSLNSTCGPCPQGLEGDGRFCQDIDECELYKDEPASSGGRGCDQICDNLLMDYNCSCESGYSLYIDNRRCIDIDECEMDLHNCNVNAVCNNTQGSFECKCKPGFRDDFMDGTSCTDLMECMDNSSYTCDEKAKCENTIGSYLCVCIAGYEGDGKTCQDVDECTRDMDDNCHAEADCTNTVGSYTCACGDGWTGDGTNCTNIDECAASLPVCNENAECTDTQGSFTCQCNTGYVGNGMMCVDLNECTTGQDDCLAVTGECSNTVGSFDCSCKDGYTGDGRTNCTDFDECQESNDCSANANCTNTVGSYQCDCVTGYTGDGQTCTDIDECALGLDDCQQECSNTEGSFACNCSAGFTLQDGVCQTETMCLGTNCTQGDCYRASNADMCLCYSGYAIDGDNTVCEDIDECTSPSDPHMCGANSMCDNLDGSYECRCLPGYALNSDQRTCADVNECQAGTHNCDAMSQMCANDEPYFTCDCKPGFSSESFNGSCSDINECLNDTLNDCHIDADCLNNNGSFTCQCKDGFTGTGHLCFDIDECSVPTDDPNYANCSPFASCINLAGSFQCNCTMGYEGDGHNCQNIDECDSAIAACATYSSCTDNPGSYLCTCDDGFRGDGFTSCVNIDECQENPGVCHSLATCTDTAGSHFCNCNQGYQGNGTYCEDVNECITGAHECAANIAECTNNVGSYMCACMGGYVSAEGFPTGRQCDDVNECALNLVDCDTSNSQCNNTIGSFTCDCLEGYEKNALGLCEDVNECDGSPCTMANSTCANLQGTYECNCMSGFYQQNSTCLVADSKEASAVFEIINGVAVSSAGFDLATGSVTYRQELKSSMEDAFLGSSLSSSFRDVVITDLTLNSDSSTALLSLVINFKSGSGHSDLDIIMALLGQLTGSSGGQLAPDHQLTRRTFIIGDPKCDVTPCINSGECVEENLATGGYTCSCPPGYSGQNCQVAPCDVNPCMNSGDCAVDSTTDTGYNCTCSLGFSGERCETIAPCQMGHDCENGATCSNNLNIARGYSCSCVAGYSGTNCETCSLSCANGGTLDPAACTCTCANNWSGLSCNDCQLSCTNVGMLNETTCQCECDQNWIGNTCIDCILNCTSGGTLNTTNCECSCAQGWTGVDCSECPLSASSCENGGEFDANFCECLCPYDYSGPTCEVASPCLSDTSLCPDAEGKFCQPATNDEGFICQCNGFKGFFANSNGSCTQLGSLPFVMALNLPFQTAYNNPASAAWKNLAEMVISALREKLRDDSSTSGVIAVTVLSFRAGSVVAQTALAFQGQQPLVDVISNAIAAGGTLNGIPLVQGSVGYTNPSSLADCMQGDCMNGGICERSGFTPQLTCSCTASFTGERCESTVPTTPPAETTTTAAPGDGGVSPLALVLIAVGCTVTLLAIAGLVMCLCMLTRRRYDAGRIGHWSRRQQQGYSAADYSEEERRMSRLAHVMSRSPFLQTMKSNPEFIRPYVATGNEALDRIREDEARGGREVAGRLMYNRPLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6X1</accession>
    <name>A0A913Z6X1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">G-protein coupled receptor GRL101</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047558.1">
        <property type="nucleotide sequence ID" value="XM_038191630.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191630.1">
        <property type="protein sequence ID" value="XP_038047558.1"/>
        <property type="gene ID" value="LOC119721550"/>
    </dbReference>
    <dbReference type="GeneID" id="119721550"/>
    <dbReference type="OrthoDB" id="5852403at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1220.10">
        <property type="entry name" value="EGF-type module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908000" description="G-protein coupled receptor GRL101" evidence="15">
        <location>
            <begin position="28"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1869"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1902"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1962"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1993"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2068"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2116"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2152"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="1294"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="1439"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="1881"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2182"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1238"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1593"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1605"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1644"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2213" mass="246095" checksum="453059A3DA249656" modified="2023-02-22" version="1">MGRAWTWLVPPLLAVALHLVCYTPVLSQNFPDEFCRAVQLNSSNQVVVISDGSLTLCLNVTAPPGTAIRATLHRSVAIVFDYSVCAFSFDGFEFFSTRCREKIEVFSPRELLTMVPPYNPGSRPRFSFEAVSNEQVCGNGDHLCTFNNGSFCIGENTTCLCLTDGYCYDYEEVCPYIVLDSNQAVSISEEVGLYSEWSGDVTKGTSCWAVPVLYDIVINVTFQSSVDQFFTRITHKTFEGVLIKHYDSFVVPRTASFVNGFGLIILSAALYNESSNSTFSFNLQKNRFNIDYFGGYQEGRVTCRPDEFKCGTGGVICYDSTIVCDGRQDCDLSWRHDERDCDYCENDDQIILPRNSSYDIKYPAGQLRGDPTILTSTRASCSWTVQASSDQVIRIRFLVPTTHSLLKWFQLNFFVGSPWQPVAAFWKFDKSSMVIHSSEVRITFSKIIFEYPSRLYLRIESEYPASCKNETEFSCVPDNVCIPISKRCDGFPDCDSKADEIGCGTCYSHQFRCLTSDGHSTCVFSSYICDQQPHCQNMYDELNCATCGPPVDVSDGGIYQLTSPHSSDSQPITCVWLVYASPGHLINIRVTDTSLIISGNIRVGSGHDPSNESSTIINKSTGTIPEGFTVHLGRAWISCVVSNNNFSFEITQLSEVVQCNTTTEFACSSGVQCVAADLRCDSLRHCDDYSDELGCLTCSKDQYLCGHQGECVDSQQICDISNDCGNFEDEWECYSTCGPSLVNVNISAVLSVPSIQHSIYVCVWQITSDLNTYLTMEVVTMEIGPESYISFGNGHEISSMLAKETDMQVAGTLYLFYGNQMWMVAHIFSDAFDFEATLNAGTIRGSCDAQSLQSGSKCVPGSSRCNGRADLPDYSDEVDCGVCGTTNLNLSTHKEVVTVEVAYGHDGYKQQLVTVSVRDHQNIPLVIANTTSNISECVWKVSSSRGTRIEITVARFVGTNLRIGNGHDPSEGAPIWSHSETLLSRKTLFSSGSAVWITTVVYSYHWEPYQLQFTLRNFTSIDCDEGQFACTSETMCLNQSSVCNGIHECPTYADELSCTSCQEEFLCSTGECIAIDNVCNRYSDCPKRNDEFNCGFCGETNIALNASVSRFFTAAFDVNRENDCVWTVTAEPSTRILITVTTHRYLSTTFCDGNYGDFVRDSNRSGCTELATLQGSTAVFRRQASSSGPALWIEDTVHSYYDNRDLTLTLSQFVDIVCQNGEYMCPSGRTCIDQSAVCDGWPDCPEYEDEFGCRGCSKEEFACRTGSECYEKQHICDGSLNCNDFSDEFHCGPCSDRHVNMTLGYANLTSPGWPWNYPTNIRCYWFVLAPEDHRILVIFLEFETENRFDYLKWSSGRTLTDGLKISGSNSPSRIASRGTELSLHFFSDWSIEEKGFLLQLEQRPTDEISCEVGEVMCQYTEFICVPPNTEVLQCPQNNCGEDTVLVDFLPVNFSSPNYPANYPAALDCTWTITTSWFLVIFVQIEDFYTEALYDVVQFQGPTFYGDLTSDFKMDGTTKVRSMVFNSSSMFIKFTSDTARERRGFRVSIETVPIFSPHFTWCDVDESSGEDCETMLIEEIPVSCDMHNNSLFDCKDGSCVIPEARCDGFTDCNSGLDEQNCENIHCPEFYACNVSSKCIYWQEVCDGTADCGSGDDEIDCVNKRCPNGCKCSYDVDDFHVRCQQGWSQNTLANTAKRTGALELSHGDIRTLELGAFKGLHYLQALYLTDNNIQQIDQGAFAGLNITYLDISNNNITRIDSPIFYELEQLETLMMVNVPIRSISAVAFLGLSSLKTLVIIAKLRGDMFIEVEKGAFQELKSLQTVYVDDYRLCCDFVELEHFSVETDCRTTELQPPLNLCGSLLQNHVLRVALWVLGLSALLGNVVVIIWRIKGAGGRGGKKTHSFMVLNLAISDFMMGVYMLMIAGADLSYGEAYFRTASVWRSTVVCKIAGVISVLSSEASVFFVTLISIDCFLCIAFPFSRGIHLQDRSTKIVVGLLWFVAVCLSVVPTVSVGPDSDLYGLSDVCIGLPFTTKAAGADTIQAELNTNNPLGSQQLTLNVGTDKKPAWILSVVLFLGVNLVCFLVVFCCYVAIFVSVKRSSKLVRKSAHRNREIKMAVKMAVIVGTDFACWMPVIIMGILSQTNTIDIGADMYGWIVVFILPINSSLNPYLYTIYSACTPRATSNSNSIDKPDKKNRNTRSVETLDVSMSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7D3</accession>
    <name>A0A913Z7D3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046921.1">
        <property type="nucleotide sequence ID" value="XM_038190993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190993.1">
        <property type="protein sequence ID" value="XP_038046921.1"/>
        <property type="gene ID" value="LOC119721099"/>
    </dbReference>
    <dbReference type="GeneID" id="119721099"/>
    <dbReference type="OMA" id="SIIACHA"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="546"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="839" mass="91344" checksum="84BFFA4AA5E684CB" modified="2023-02-22" version="1">MVAAGPSAGGSIPDAAHVSLTSPGDVILGASLPMHGWSSGPPCSGSLGLWGNELAALFWFAIEEINNRTDLLPNVTIGYDIRDNCYSETLSIWTALSLASTSERPQEDVEFTKISPAEYGNLFCIIGTQSSATTIPTAQAASLYRIPVISPFATSNELSNKRRFPYFLRTVPPDSVQAKAIADILLRFGWKYIGLYFQLNTYGIHGAQALLDLAELHGICVAFSVPVRSPGTKAELYDAVSRLAAFPKARVVVIISDAPAAGSIVRTIEELFGILHNITFVGSDAWAFPSSLQAYYGVDLRGLQGSIYVQLKYNQIPGFQEYFNSLETRDAMFSSWFQGFKDIWMKDNQCSDIALCPMRLNNNDNFLVDAVNAFAYGLQDLLRDRCNDTTDCNSTIQAITGQDFLPYLLGLRFQGLAGKYVFDVNGNPGGKYKILNYQFQDDVFQEVSIGEWEASEDRRLDVNLSAIQWVGGSRDPPASLCREICTPGHIEVPLEKKCCVGCQQCQNNAIVHNNLCEQCPVDEWPDASFQVCRPIVPTPPSWSEPTVVSILILSGLGLVLSLLAALGLFHYRHHVLIKAASRELSSINILGLTLAFLAPFPLLVPPTAVSCRASEIIVALCFTLTYAPTLLKVNRIYRIFNAGKKSNKPPRFIGPRSQLTIVLGVFAAMVVVAVAGTLASPTLPAKLIFYPPADYIEAFCEFGNGFLASLICNLLIVLVCCYYAFKARKVPSNYNESKFIAISVYSTLVFGMAAVPVYITAATVLQKVATLCVAILLNSFLTLFCVYLPKLYAIQLAMDVQVSEWRANDESSSGTGSTGVQSTSGTIKVQPVSGAVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z871</accession>
    <name>A0A913Z871_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHFL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047206.1">
        <property type="nucleotide sequence ID" value="XM_038191278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z871"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191278.1">
        <property type="protein sequence ID" value="XP_038047206.1"/>
        <property type="gene ID" value="LOC119721281"/>
    </dbReference>
    <dbReference type="GeneID" id="119721281"/>
    <dbReference type="OMA" id="WWRKVFS"/>
    <dbReference type="OrthoDB" id="9423182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026795">
        <property type="entry name" value="SHFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135">
        <property type="entry name" value="REPRESSOR OF YIELD OF DENV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16135:SF2">
        <property type="entry name" value="SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15135">
        <property type="entry name" value="UPF0515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="259" mass="29336" checksum="AF036485783C48A8" modified="2023-02-22" version="1">MGDDMERTFHIPVEKLLDKHTTVSEDVKRKRIKAICTAITIESGSAITVQYDIHDNGTISFRIHGPMDKISIVIGLLERHLKQERRQERSTLPKNVAPLTVDNLRTHNHTMMEKREFACQPCQNVWWRKVFSYKPVSKCSRCHVLYNAVPMDKVFGWGKFTCHCGNVFFGRAQAGVPSICYQCHASVLPDVGSIGPMRINGPRQNTRNRHACDLCDNGRIQPCPGYNKVLCPSVRHVSTGSTASTFLTQSSYAYREPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9W8</accession>
    <name>A0A913Z9W8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048556.1">
        <property type="nucleotide sequence ID" value="XM_038192628.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048557.1">
        <property type="nucleotide sequence ID" value="XM_038192629.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048558.1">
        <property type="nucleotide sequence ID" value="XM_038192630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048559.1">
        <property type="nucleotide sequence ID" value="XM_038192631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192628.1">
        <property type="protein sequence ID" value="XP_038048556.1"/>
        <property type="gene ID" value="LOC119722485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192629.1">
        <property type="protein sequence ID" value="XP_038048557.1"/>
        <property type="gene ID" value="LOC119722485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192630.1">
        <property type="protein sequence ID" value="XP_038048558.1"/>
        <property type="gene ID" value="LOC119722485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192631.1">
        <property type="protein sequence ID" value="XP_038048559.1"/>
        <property type="gene ID" value="LOC119722485"/>
    </dbReference>
    <dbReference type="GeneID" id="119722485"/>
    <dbReference type="CTD" id="133690"/>
    <dbReference type="OMA" id="MKGVYHA"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="24125" checksum="275FCC74397532B8" modified="2023-02-22" version="1">MAGTARHDHEMKMNARKKLQTTKDPIEKLRLRCLERGSAGIKGIGRVFRIMDDDGNRTLDYGEFKKGIHDYGFSFDDKAIKEMFAAFDRDGSGKIDFDEFLLSLRPKMSNTRIDIICEAFKKMDKTGDGVITIEDMKGVYNVKKHPKYLNGEKTEDELFRMFLDTFEPDKSKADGKITREEFQNYYAGVSASIDQDSYFILMMKNAYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBC9</accession>
    <name>A0A913ZBC9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048879.1">
        <property type="nucleotide sequence ID" value="XM_038192951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192951.1">
        <property type="protein sequence ID" value="XP_038048879.1"/>
        <property type="gene ID" value="LOC119722699"/>
    </dbReference>
    <dbReference type="GeneID" id="119722699"/>
    <dbReference type="OMA" id="MRGCGEM"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1007" mass="106383" checksum="E3CA930FA5C4C099" modified="2023-02-22" version="1">MDARDDEWHRTRRRARAMHHPMATERDFHDFARMPGGIWWYVEELKQQGNDIVHHKPREAVGLYTKAMEIDENPEHPFDLLTPREKAMLRSNRCTALMKLQQLGPAFEDAIECIKIDPSFQKGYWRAATVMKQMGKEDEALEALIDGYPKILGDGKEADDFRSNFVYEITILTVQLWDKWQKSQFLFRLLDVSTSVWTEVVQRLARNKEYQGLHLVFLRGGTQSGKTFEIGQGGAAKGCDTSGIDLRPLVRDLSSREYDSWSMQLVVELLKHGSKVVGLSQKEGDTPLHCAVENALRTGWVGLLEYLFIHLYTTSGGRNQPDISGDSVFHLVAKKSGPAAHTKLVVDVLQKYGVLAWDQHVKVQQKQQQQQQQFQQQSRNPRPSDSTPFFDHSQLFVGPQQEKCRQEEEQRKQEEQRKREEVQRQAEAYVMKLEEEQRQMEAEEEHWRHEEKIQKEKERQERLRLQREEKKRKENLKRKERRRMQKKKETDMATGRDDEVKADGGAAVAGTAIVGTTEGRAVKTGTAPEGGRAEITGGREETARGQKMGGAKKGGRAEKTGGAKNGGGAEKMGGAEAKGGAKKTGGAEKTGGVEEIGGAKETRGAEKTGGAEDTGGAKKGGGAEKGEGAKETGGAEKTGGAEARGGAGKTVGAEKVGGAEKTGEAKKTGGAGKMREAEKKGQAEKMGGTEKTGGVEETGEAEKKRKAETKGGAEKTIRAKKVGGAEKGEGAKEIGGAEKTGGAEAKGGAGKTGGAEKQGGAEKTGGAKETGGAGKMKGAEKKGQAEKTGGAEKTGGVEETGEAEKKRRAETKGGTKDTGGVKKGGGAEKGGGAKETGGAEKTGRAKKGGGAEKGEGAKETGGGEKTGGAEAKGGAGKTGGAEKKGGAEKTGGAKKGGGAEKMGGAKETGGAGKTGGAEKKGGAEKGEGAKETEGAKETGGAKETGGAEEVGGGEAKEGAEEMGGGPATSQSLSDETGGPAPDGSRRVGEEAAAATGQGRTEEERGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD29</accession>
    <name>A0A913ZD29_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vitellogenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049424.1">
        <property type="nucleotide sequence ID" value="XM_038193496.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193496.1">
        <property type="protein sequence ID" value="XP_038049424.1"/>
        <property type="gene ID" value="LOC119723021"/>
    </dbReference>
    <dbReference type="GeneID" id="119723021"/>
    <dbReference type="OMA" id="YGHCHHR"/>
    <dbReference type="OrthoDB" id="10058647at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037363665" description="Vitellogenin" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="9">
        <location>
            <begin position="25"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="1524"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1646"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1889" mass="215556" checksum="589FD3732F817AB6" modified="2023-02-22" version="1">MRQLLLLLVGVAFAHAAVPTQEGYFAAGREYLYRYEGQVLSGIPGVSKEVAGIKIVADTRIQMRDDNKCLLELEEVELSKLQTETENPAKQQSQDKLQRLQPEIEHPILHQLVKTIEFRYVDGKVSHIVTSQDEPVWSANVKKAILELMLVNIRGTDDLNEPDSQSTQPSNIIRQKEHYRVMERGIAGNCESVYNVKVSKPVSNIIDKQVQPQRFVLNITKTRDLMECQQRTQRSKLSILSGKKCQRCQKEQQQEDTQRPLTNEPIPEPFSQPTEKKEDLMKCLSQVRYSISLKDHTKFVIDAVVAEGKHIFQPFGQKGGRAVTFVNQTFILKNTRETPPDQLIPDVTNPKQQPEDLGFVFQDWTKHQHDAEEDRELTAEDGPHMSQIRHKVKLFLQTIYDSIHDDRITEDAPKRFILLVKTLNKFSPLELTHIYDRLGKKFASDTEDVKEKKQILLDALIQVENDKSVEILIDQIGKRNLIKEEASQILSTIALINEPTEDMLDNILRLCKGPVLNGINADKQVRKTCWLSFGSLVHKACKINQVCSEVKKQEYSLNLLAGIDPSRTPEDQRMCLKAIGNAGLILKHSTDAETDSIDRIAEIIKSKTVDVDLRVQGIYSLRRLAKNEPQRVVPLLMPFVKNMEEDPQVRVAAYVIIMDAEPKADVVLSIVNDLKQDKSKQVASFVYSHLEGLVSNYQYCKKNLTKVARKALLTLKPIVQGALYSKRFMWSPTSWQQKISLSTEASLIGTPASPFPVSGSVKLGATILDHSLNIVEAGFHAKNLRDIAEKILGIARPVRKTKEFMKKLNAPLPDGREKSPAQRDLDALDGQLRTTVIDSDTNALKASGYLKFFGNELRTVTVDKPTIWSYLEGTSEKMVDIEDKMRSGENPYSYRKLFSLGRGVHEIPTEIGLPLQLWVDSAAMVALDVSGRAVLTPRLTDVLSDKAVKLETVDVTGTVKPRAAVSIMAKMKISLDNVMSGLYLNGAMNTSAVLTGKLNVDVAKKLYETRFDTPSTEHQAVSLRSRPYTFTYIEKPEQETIGTPEVVRESQENNRYTFNKRLIKGKLMSPRPVTSTWNIGKESLGVEMELKTRRVPRSCSFTNGPTHLIFNGPVDVNVTVRPGQNAPRNVVAYMKLENEFKTQQQYQEFKEKFLLKQHFMTESSSEESDEHDHVNGKDVPIPMYQKPQTSFRTVGMEFLKRFEDWKYDSAKWPFTREEVEDRSHDHTEEVIPDSTKSVELYHIYFNVTTNGTQPIRELVSRISLDQQDEFYKAVRFDVMTAKKIFRPDPVHQDQLREETEDIQTLCIQGELEHPAYAVTLPESQKLEPIQGLPDVPLDPKVLFKFNSQWGKSCLDDQKMQIKARVQRSEKQQRELLEETPDKIECLKNIRETNKCSQACKALRKEREELRAIHAELTHNEMVKKPYKAFFYQGLEMVKNLIWGRVTTEQAEVHNPDKTALLTGELEKTNKKMNISIKHVRGNVKFERVWIPQIIQDLKVLQPYKLQRHMVMSYSEDMLSGRNIHHCKSLRNDSIITFDKMIFNYEQSKCDHILAKDCSSKERFVVLSRKLTQTGTKKIITVYIDNTKIQFVPNSLNEDITTLVNESNVNLEVLQKLIVEDGVIKKVAIDSPTVHIMDLEKQEEESLWPEPFRTSRERKQQSWDMPESASSEEVEMGSEELQYWEDFKDHVKADIAMAPQQLSAKPKTIAKIIRKKLGDSIMLFAPEQELKVFFDGHNVKVELPLKYKGLHCGLCGDFNGEVSDELVGPNRELYKNPHRFGRSFQHTTEQCAKEDQCAPSMEFAYDTEISLPGNKNQFACITKTPLPRCLLTCRPSQEEPVDVELVCIEHEGTTDPFATSSRDVLIKKYGAKTADYKTTLPMATRCVRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDY9</accession>
    <name>A0A913ZDY9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049175.1">
        <property type="nucleotide sequence ID" value="XM_038193247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193247.1">
        <property type="protein sequence ID" value="XP_038049175.1"/>
        <property type="gene ID" value="LOC119722859"/>
    </dbReference>
    <dbReference type="GeneID" id="119722859"/>
    <dbReference type="OMA" id="ACSFRFR"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="308" mass="31240" checksum="5872B11AB3464BC3" modified="2023-02-22" version="1">MTGSVSTSSSAIWSSGQGGTSTSSTTNWSSRQGGTSTSSTTNWSSRQGGTSTSSSAIWSSGQGGTSTSSTTNWSSRQGGMSTSSSAIWSSGQGGTSTSSTTNWSSRQGGMSTSSTTNWSSRQGGMSTSSSAIWSSGQGGTSTSSTTNWSSRQGGTSTSSTTNWTTNWSSRQSGTSTSSTTNWSSRQGGTSTSSSAIWSSGQGGTSTSSTTNWSSRQGGMSTSSTTNWSSRQGGMSTSSSAIWSSGQGGTSTSSRTNWSSRQGGTSTSSRTNWSSGQGGTSTFLGPLCNLRRQRGLSEPAEVRQVLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE58</accession>
    <name>A0A913ZE58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049341.1">
        <property type="nucleotide sequence ID" value="XM_038193413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193413.1">
        <property type="protein sequence ID" value="XP_038049341.1"/>
        <property type="gene ID" value="LOC119722977"/>
    </dbReference>
    <dbReference type="GeneID" id="119722977"/>
    <dbReference type="OMA" id="PNNISYR"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="34073" checksum="2E633F289E746D09" modified="2023-02-22" version="1">MQQVFPLFCKSIGHRRHDKKMSADTRRFEKEDHAAVYVLARPDWPKDIIEKSIAFLREKKSKPFLLAVDVGCGSGQNTRPLAPHFEKVIGIDVSEAQIKAAQSVETPSNVEFRIGSGESIPVPDGSADMITVAEAVHWFDIDAFFREVDRVLKPCGCVAIYSYYNTHPLVEGDDNKNQLLKDVVLKFDSFLEPYASDRIRHVRNMLADIHIPYEETIRDDTLQIKHDTTLASFMNFFRSWSSYRHYRVKNPTGPDPVLAMQDRFMEILGLADCPLENAQISTSCPVVLLLGRKPENQPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE89</accession>
    <name>A0A913ZE89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050102.1">
        <property type="nucleotide sequence ID" value="XM_038194174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194174.1">
        <property type="protein sequence ID" value="XP_038050102.1"/>
        <property type="gene ID" value="LOC119723493"/>
    </dbReference>
    <dbReference type="GeneID" id="119723493"/>
    <dbReference type="OrthoDB" id="10398013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="43308" checksum="FFB82E9EC30317F5" modified="2023-02-22" version="1">MSNTMYVRQSRNRPSVRPGGSRRGRARSMSRSPTRLILTPANRSQTRDDSGLGRAMPARLKLQVREPANGRPARQSRRPAARPTARPTTTTSDENEMANTRSANPENFSKTFFRIVFLGATRVKTSEPSILELNALVEEIRTRARVYRERGVAIPLYTVHINAKSVALLETQTRDVQHIPINQVHFVAADPRYPSIFSMVARGRGNRFLCHVFECSSYKQCDTITKTVSEAFRVAYEKWLRVEENQRRLEERRAREMDMGGLEYFQEWDDHAPRGMPLYNISSYYNSGHARPREYLRPRDELPGLPERLIVSRSNQGNREPEPEPYSMRFNFDDDDYDDSPQEEVYVRQDVNNGRRGRQQQQPVVFDIRPDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF54</accession>
    <name>A0A913ZF54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-type lectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050089.1">
        <property type="nucleotide sequence ID" value="XM_038194161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194161.1">
        <property type="protein sequence ID" value="XP_038050089.1"/>
        <property type="gene ID" value="LOC119723481"/>
    </dbReference>
    <dbReference type="GeneID" id="119723481"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054126" description="C-type lectin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25698" checksum="C68E6CD877C1A990" modified="2023-02-22" version="1">MEAPLLLAVILGCLLTIVSNPAEAYTYQPCNNGWKHFKGNCYLFQYNLHLWGGDASFDAHQKRCKSKGGNLASIHDYDENNYIGQSIRNFKAACWIGFEDKDGSKAFQWLDGSRAEYTNWGYGHVTVTGRRACTTMQATDLYWRIDYTCDQRAVCSVCKKPSTKLPCAASRCLNGGNCVEPKWNGGKEPSDFTCACRKGYSGKNCELDVDECKTASCASGKCVDGRGSYECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH73</accession>
    <name>A0A913ZH73_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050406.1">
        <property type="nucleotide sequence ID" value="XM_038194478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194478.1">
        <property type="protein sequence ID" value="XP_038050406.1"/>
        <property type="gene ID" value="LOC119723686"/>
    </dbReference>
    <dbReference type="GeneID" id="119723686"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037138889" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="333"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="566" mass="62552" checksum="46FEF0133B00A8B1" modified="2023-02-22" version="1">MALRGKKREYLFVVFLILMTSSSKADIPTVVTHVDDEKGTCHYELKIPAQSCKQCKCQPDSLGHVVDELERRLFAVEKQIQQITSLEPPDLDISEYSSTTLSSIIENDDPYASPLFTNEGASVEELLSSSSDQDDLVPLPSNPETRSAATDQGNDLGTPGQAEIKEGFPAINPPGFKGQIEAVPGDEETSTVIELTALEKPLPLYPNQVTDSPPAKEETRSRDMEHFPGKLEGDITGTTEADEGTPPVKGTEKPRGAKLGILSGRSAGDLDSASKASRPSSSVTDVPLFGAGDDSDTVDQKKKPRWKLHDRPSAVHRPPDSRSAPRELLGRAGANCMDGCSCMRVWGYWQDGVYDISNPPGSGKKGESVPAYCDMSTDGGAWTVIQNRQDGSRNFYRQWSSYANGFGQLESDFWLGNNLLHGLTARLPYQLRIEFSDWDDERGYAVYDRFMVGSADDKYRLVLGEYIAGNRGDSLSYHNNSLFSTHDQDNDASTEVNCAQLRQAGFWFLACNQANPNGRYIYREDATGLQGGVITWGSWEGHGFTYALKTFRMMIRPVHYDRILYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHP3</accession>
    <name>A0A913ZHP3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactosylceramide sulfotransferase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050873.1">
        <property type="nucleotide sequence ID" value="XM_038194945.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050914.1">
        <property type="nucleotide sequence ID" value="XM_038194986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHP3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194945.1">
        <property type="protein sequence ID" value="XP_038050873.1"/>
        <property type="gene ID" value="LOC119724023"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194986.1">
        <property type="protein sequence ID" value="XP_038050914.1"/>
        <property type="gene ID" value="LOC119724066"/>
    </dbReference>
    <dbReference type="GeneID" id="119724023"/>
    <dbReference type="GeneID" id="119724066"/>
    <dbReference type="OMA" id="TIFCAKA"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42719" checksum="C98975813B31212D" modified="2023-02-22" version="1">MGTERSSSAVRCEPKQRIVFVKTHKTGSSTVTTMLQRYGYKNNLNFALPTKRHVFYEFVKFQASRVFQYDLKDAKGNLVWPALGGFHILANHARYNRSEQDALIPNAFYFTIIREPASQFESAFNFYHMDKRMPKHAMTDMFQIPPKWFSTKVKHFFPFMRNGQMFDLGLDQETQDNKTVGETFEALSHEMDLVMITEYFDESLILLKEMLCWDFDDITYVSQLVRKSSARKNLSSDLMEKIYKLNHADVKLYRHFNRTLWDKIHAYGPGFQDDLETFRQINAAVNEQCLTNATMSFTRSQKLSQYALPQNASEKCRDYIRLDQRWVPMLRDYMARKSSAFMNNDLQRNRLSKNVTVGFNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIY7</accession>
    <name>A0A913ZIY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051324.1">
        <property type="nucleotide sequence ID" value="XM_038195396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195396.1">
        <property type="protein sequence ID" value="XP_038051324.1"/>
        <property type="gene ID" value="LOC119724374"/>
    </dbReference>
    <dbReference type="GeneID" id="119724374"/>
    <dbReference type="CTD" id="84945"/>
    <dbReference type="OMA" id="WLPEQGY"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="190"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="427" mass="48393" checksum="A6AFF69C68B1CD8D" modified="2023-02-22" version="1">MRRQNLPFDSELRHYLMNPSEGVEDSNHGQNMSDRQEEVGHPSRPATSAPQESVQNTRSNPSPKRNSAKKKSSSKCSILCRLFYNLLNYVIATFWGLCTAWILVLVLVYLFYGTTLALVLALVAILGLAYNIQDKLLYFPDEPESSRFYVAPPQSTGLPYEDLYLQTSDRVRVSAVLFKQAEPLFSRAPTVLFFHGNAGNIAHRYFNAHGLYAMCGCNILFLEYRGFGRSEGRPSEAGFYLDAQAALDYLHRRGDIDTRRIVVFGRSLGGAVAINLASQTVNRGKIAGLVIENTFTSIPDMGTVIFRTGLLRWVPLFLVKNQYFSINKVKHIRTSTLFISGVEDELVPSKMMHELFLRCGTKNKQLIRFEGGTHNETWRCHGYFTVLREFLTQATYRETQLIKDLPVGAQRVRDTSETSTRHHIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJK2</accession>
    <name>A0A913ZJK2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051250.1">
        <property type="nucleotide sequence ID" value="XM_038195322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195322.1">
        <property type="protein sequence ID" value="XP_038051250.1"/>
        <property type="gene ID" value="LOC119724328"/>
    </dbReference>
    <dbReference type="GeneID" id="119724328"/>
    <dbReference type="OMA" id="YHYICER"/>
    <dbReference type="OrthoDB" id="10058112at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037645219" evidence="12">
        <location>
            <begin position="19"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="13">
        <location>
            <begin position="189"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="14">
        <location>
            <begin position="438"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="612"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="874"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="905" mass="99774" checksum="A76FD07EDC21F792" modified="2023-02-22" version="1">MERGFIVIFILSLSATHGAIETDATPIQISSLWDVSRALWHNETCDDLCACLMGIMEGMRTAQICLEVSGYPCHLVKQLTRAATTRNCSVTVGSSWFECDKGVTDCVGGEMFVDNEANCTGSDDGAAGNIAYLGCETTPGGNTSVTCMLSRDSQSVGQCVNNAECVYKKVTKTDPVSERVSCPTNWIPYKKHCLSPINGILEPNILDQKTWSGAQNYCQRRWDASLLSLESFGESALKGLEDRRIFVTDQEVWLGLFRDTSNSTFRWLDGTETLQPQDSWPWADGHPVPDLNFVYILNKTLYSSESSRVNRYSCKFKVSKSLKCRQPMPTKMPLTTVMDAVGPGSTHPPTSPRTKEEETLEAFREELTQVRDDVSNYLKTFTNDTGVLEEIDSLISFSQYSSLNASSNTKAQDQSTTIIKSLDSVVDGLAESINGPAKALVVSTPDIVLKVLTLCLDCEGGETLGGQLGNQSFSLSLPDSVKAAGATLALSTASLLHEQLPSTIDDGGEGGRTEIGSLVSTISLRRWDRESIELTKDEPLKLTFSSLEKFPDSTPTCRYWKADEGNEGVWSSEGCFVAKANDTHTTCDITHLTSFAVIMQISHSEDPLPVALDYLTWAGCALSMTCLTIMLIIFLSQRMYRADRNIIHMNLAASLLLAQLIFVFGIDRTENEGACKAVGICVHFFLLATFFWMLNEGIFLLSKTTSAKTRWLRLPTYFTLGWVFPLVIVGVTMAASFDSYDTTDRCWLTVRDGGIWAFVGPAAAVVLINICVLVQVIRVFLSLRANMNKKKVERIRIALRAILLTLPLLGCTWLIGMLSFNSSTIVFAYIFVILNSLQGVFIFILYCLLNDEIKKGLRKRLALLQSLSGRTTHTRASRTATSGSNNLKTNRLSKTMPPEQEGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLM4</accession>
    <name>A0A913ZLM4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052000.1">
        <property type="nucleotide sequence ID" value="XM_038196072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196072.1">
        <property type="protein sequence ID" value="XP_038052000.1"/>
        <property type="gene ID" value="LOC119724827"/>
    </dbReference>
    <dbReference type="GeneID" id="119724827"/>
    <dbReference type="OMA" id="EKRFCVI"/>
    <dbReference type="OrthoDB" id="9906976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="513"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="587" mass="65479" checksum="B19312930C1AA596" modified="2023-02-22" version="1">MANLTDDVARLQLKESMLDGPKGRYPPDGMEMKPTCMSQANSGCYSRTESLDVETDAVPSNEDVGQALDMRDQLGITQEMPEKSTEEDIPVKDKEMPDLITSSKEPDLRNDTKTAISPNRENPEQQQTKPSTVLPEGQLARVEDRNHTQCSDERMRANKTGDSHTDTGQAPVDDIDVAKVHISDHPAVPAAPCSRDIQDGTTASQPNSKPATSPKKRTMAPVFSSHQAPTAPHTSTPPQETNTLTSEHRSQVSHSVPPVSEDIGEVTTAAQPDSQSTIQGKLNMAAAASSSPLPYHQSARNMATSPHTPTQETIPWEEEHFDVLLLHSEHDTHHVEKFMEYAKRYSWKVTSPDEFPANLLKQIGFNSAFERSSFTVLLLSGNFLKDCWCEMRYQTALVQSIENPEKRFCVIPIKCQDHFKMPMELSVLTGVYLKAANCEKILKNTIRIERRIQREKMAASAHQGVSEVETAGLSLDELYNRKRPELNPGQSASHVFLSDETFRQICVRLDERNALGRDWRLVAEKMGFKASSIEALKVEKSPAAQILECFCQLKTVQGKSRKDILEILRKILSDIQRADVADILTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMJ2</accession>
    <name>A0A913ZMJ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052281.1">
        <property type="nucleotide sequence ID" value="XM_038196353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMJ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196353.1">
        <property type="protein sequence ID" value="XP_038052281.1"/>
        <property type="gene ID" value="LOC119724987"/>
    </dbReference>
    <dbReference type="GeneID" id="119724987"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="14" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="18">
        <location>
            <begin position="359"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="831"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="931" mass="105386" checksum="420B7BCBEB04E4DC" modified="2023-02-22" version="1">MATPGGMMNKKKKDFLGVSAPLGYVPGLGRGATGFTTRSDIGPAREANDISDDRHPAPKKKKKDDDDEEEDLNDNNYDEFAGYGGSLFNTGPYEKDDEEADAIYEAIDKRMDEKRKERREKRFREEIEKYRQERPKIQQQFSDLKRELSEVSEDDWLNIPEVGDARNKHQRNPRADKITPMPDTFLQKHAMSSETMTKLDARQQALGGIATPFPGAMTPGMLTPTGEYDLRKIGEARNTLMDVKLNQVSDSVSGQTVVDPKGYLTDLQSMLPSYAGDVADVKKARLLLKSVRETNPNHPPAWIASARLEEVTGKLQAARNIIMRGSEVCPRSEDVWLEAARLQPGDTAKAVIAQAVRHLPNSVKIWIRASDLESETRTKRKVFRKALEHIPNSVKLWKLAIELEGQEDARILLSRAVECCPSSVELWLALAKLENYDNARKVLNKARENIPTDRKIWITAAKLEEAEGNHTNVDKIIDRALSSLRSNMVEINREQWIKDAEECEQAGSIVTCQSIIRAVIGVGLEDEDRETTWMDDADSSASHHAIECSRAIYAHALTVFPSRKKIWLEAAYFEKNHGSRESLESLLQKAVGHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEDERARRLLARARNSAPTARVWMKSVKLEWQLDCIDRARQLLDEGVKHYADFAKLWMMRGQIAEQLGEREDARKTYQQGLKKCSHSVPLWLLAARLEEKVGNLTKARALLEKARLSCPQCPDLWLEAVRAESRAGNKNIAQATMARAMQDSPSSGILWAEAIFLEARPQRKTKSVDALKRCEHDPQVLLAVSKLFWSERKISKAREWFNRTVKIEPDLGDAWANFFRFEIQHGNEEQQESVRKRCVEAEPRHGELWCNVSKNIKNWRCKTNEILPMVASTISTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMV8</accession>
    <name>A0A913ZMV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052440.1">
        <property type="nucleotide sequence ID" value="XM_038196512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196512.1">
        <property type="protein sequence ID" value="XP_038052440.1"/>
        <property type="gene ID" value="LOC119725152"/>
    </dbReference>
    <dbReference type="GeneID" id="119725152"/>
    <dbReference type="OrthoDB" id="10041400at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="151" mass="16903" checksum="FD279C74C2B8710A" modified="2023-02-22" version="1">MNDYILFLTDDPCESNPCWNEGSCVNSSADFSCICAPGFIGLFCESQSHPLDLVFVTDLIPPGIYVAPTDTFNFTLIPGLDGSHVNIRQPRAINYDPLERMVYWTDYDGTFSTLNRAFLNGSGVEVLFMDLQGKPIWHFVCLCWPSLCLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQZ1</accession>
    <name>A0A913ZQZ1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053560.1">
        <property type="nucleotide sequence ID" value="XM_038197632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197632.1">
        <property type="protein sequence ID" value="XP_038053560.1"/>
        <property type="gene ID" value="LOC119726011"/>
    </dbReference>
    <dbReference type="GeneID" id="119726011"/>
    <dbReference type="OMA" id="ICKQETA"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="661" mass="74897" checksum="9F7CCD18B6F1D780" modified="2023-02-22" version="1">MAEAAAKYVLGTISRGHLECLICCCRFIDPKMMDCLHSFCLNCLEELISRQQPKADQITCPICKQETAVPDTGLQGLPNCFSLSSLVDEFNKQERLLEDEPSNAPPTCEECEEGLEAVSRCLDCDGNICQKCRDTHQKMKSTKKHLIVNLDQSEAQVPTVDLLKKDIPQCNKHTTNDLCFYCETCKTLACAACVALDHRGAKHKYREVADAIRSYRQDVGKIMQRFENNRHEYKVTDDSLSHARNRLKIMVARACKDITAKEEEEFAKIRNKSRLLRDKVTQIGEEREKKFEEVQKRNHDKMERAEQIVATVNKLMQQADDFELLDLKPKVMHNLECQEKLRLEHAQHGLSFVGVKCQDVVADADLGEVLEHEIWQSEEEFHCWDVPEFDQSDIDPSDFAISVACLGNGDIAVNDLLGQLVILTSTGWYKSKVNREKLNRPARVAASSDGLLLVVDEDYVKVFDSSLKFIRQFEPSRQINEVDGEPESNVSGIAVDKKHRIAVADRGRKLISLHHLDGSLITAIRHDLVDFGLAIGIEERLIFTNYRESKLICTTYTGEEVFNIKIYFSLDPVRPTGVCCDDAGDIYVSVHCEEPEHSRVFHYSAGGAFMGPVALGLHSPYDLTFTQRGDLVVADEISIKFFQRVSVEQSRKRIVHCSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR84</accession>
    <name>A0A913ZR84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FAM33A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKA2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053660.1">
        <property type="nucleotide sequence ID" value="XM_038197732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197732.1">
        <property type="protein sequence ID" value="XP_038053660.1"/>
        <property type="gene ID" value="LOC119726123"/>
    </dbReference>
    <dbReference type="GeneID" id="119726123"/>
    <dbReference type="OMA" id="AMFQKAD"/>
    <dbReference type="OrthoDB" id="193920at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000940">
        <property type="term" value="C:outer kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026762">
        <property type="entry name" value="Ska2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042091">
        <property type="entry name" value="Ska2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32017:SF3">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11362">
        <property type="entry name" value="DUF3161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16740">
        <property type="entry name" value="SKA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ska2 N-terminal" evidence="15">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="273" mass="30304" checksum="C2429EBA4964BFA6" modified="2023-02-22" version="1">MESSQQIGEREGEKLCHDMANSVDKVEALFRKAESDLEYMSRKLEDEFRQQLGGNNQHLNPSEMMQRLQRVKKEYNSLVQDAEGIKAMQSQMASYFRSQLQTACTAIKALQENAPQAQITDSSEQEAVVDSILGLRLGDQTDTNQTSDGEVCTKESPAQESSQKTKNTSGKATSELSQAEKRARNEGFTAITEEELQSVSPLVRGRVKLADVNAVYRTLFEHFKVNGNSESLTIQDMSKKGLRITGATGEAKLKVLRALKVLHMSKNGAVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSI5</accession>
    <name>A0A913ZSI5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054587.1">
        <property type="nucleotide sequence ID" value="XM_038198659.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054588.1">
        <property type="nucleotide sequence ID" value="XM_038198660.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198659.1">
        <property type="protein sequence ID" value="XP_038054587.1"/>
        <property type="gene ID" value="LOC119726802"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198660.1">
        <property type="protein sequence ID" value="XP_038054588.1"/>
        <property type="gene ID" value="LOC119726802"/>
    </dbReference>
    <dbReference type="GeneID" id="119726802"/>
    <dbReference type="OMA" id="ENWHERQ"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="763"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="961"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1246"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1308"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1358"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1442"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1822" mass="201669" checksum="D44B2F9888BEA05B" modified="2023-02-22" version="1">MAQELGLFQGPTQNGPPSVQHKQDRRSFGGFGDDGQGMSTDSMVPDISPDHASRSRLNPDQSEDSNPQSSPRPNRLTLSSVEFHRRAGNDATSSSASVWKDGESLNSEETMVQQLMRKISHVGNGDDGPKTAANYTGFPSGFQRRNYYEHSKKLTDLVDVTYNPRTRQFIFLDTRGITTWDKDGIEHTVTRSLSYPKYVNKLLRNIIYARKYNVYFCLAKDFSLKVLNKDFDETCNVASDLSSVMFLIFNPVRDELITGGVKGTKVWEFKQVTDQVWTEIKPMANYGLFLKRELSGIKGGWIRKVELEQQLQHLYCCSDTDVLCYNMDGKPLFRLVDAHKSQINGCKYSPQAKTLITCSNDSDVKVWSMTGGHVHTFRGHSRSVTGVVLHPDTSTLVLTSSTDGTVRMWSLDIMEPMYTIVISTDGIEWLGLTGERFLWTATHRDLGVWHLNHVVQFYALARCRVTSLHVAGCEGKTSRLVAVGEDSSVRLISMKDQKSLSTVLPPPSISPLQQVLGVTYNRECSVVYLLISPQEIWVYTMRTDPACRTAVWDTEHLQDKVNRGQSAGSRAGSAAPTTPRLQPGVKGLSSVQLGHTLPTHRASQGRGAHTTPSPCTSIATITTPVMYWTEEGFVCPLNQNFLVLGLQDGRILLMDPMEYGHRYCELQASKDAIFDMEFDHAHSALVAKSHLRDEDVYQFWSLPSLELQHLVVVPRDVTAFARLGSVFLTGHSEGSLSLHQLKPVTNMMGYPTNDVGEEMRETRRDHTAPIVAVDSCLNLAIFVSCSSDGAVKVWDADKLLLTEIALDEPISCARFINARGDLMMGYMNHLFVIDHTKILPSSSKTQFPDENLETESEIYEDPAVRYEGAAENPDPLDLDSYLVPYNLDFNERFRGGRASPSTSHASSVKSGDEDSGSEFSLAPTEMYTSPYMTPRRLSAIDLLTSGQDTRRAEITSRVKALSLTRKRRSRSSRLNLTQTDDVQLDFDMPQFGISPGPSPTPSPPSSGSDFDVSEDESEIEDDSGSEAEEEGEETQHKEAGSKMTVRASELEEVKKKESKEIKVGDIRLSDLKQPPEEVSKYSMSKMKIDAKSLLKQKIPVTIPKPLKLDRTSQPLMATVAEIKTLEEKVKKPTGQPRMKTPVKKKMKKGERVRVGDRAAANRAKLAAEPSAETIPSPTVPSTTDMTTATKLTVSLEGGVKEKVQSGVIKKVSSSSASSSSASLSQQTSDSSIKPKPKVSIPALPKAPKDSKPEDKKSSKPADKPAKAKPEKGKPKSVLDDWKKPKGGTSATETTACVSDEEVQRAMSAGTSGSSGRPASSVHGADVATDLGEGSTAMYKAAARMAIANKYNPLRSKSAEATPSLTDTQPDTVTNLDPEGLGDAGELESLRADSRFDGVLSRGSVQSVTSPPGRDLESPAATSGQRSRMEGTYADGEEDQDTSTRPPSRHQVSPEQVATTPSPKISSTLPPRPKSHIALPPRPTRLVDRDHATREARPEDRYRGKEVFVPTASTEEQVLVKEEMEGRLARPNTAEGRSLLLQRPHTAGATLHVNFEDEQTALDGHDTPIARYLSCPGSPVDLRHIYRNDGLHFEDNWQEKMIVRHHILKQQKEQRAQSAADRRRLLELRKRQRRKALLGHHHCATDGTYESPTQETYVTRSDTSLHKMKRCQSAPIGRMVPSSSPPVQPQQAFGQSKEVDLSSETPYRFRINRSAPQSAKPRIPPEEIFEEVAPDPSHPGSLLIKRPQSTKSIPSKTRRYVLVTKVQDDPDIPVPTVLERQLLKERFPQTRHRIKHLQEIHRRNSIPNMELINISSVGDGPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVH6</accession>
    <name>A0A913ZVH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055076.1">
        <property type="nucleotide sequence ID" value="XM_038199148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199148.1">
        <property type="protein sequence ID" value="XP_038055076.1"/>
        <property type="gene ID" value="LOC119727294"/>
    </dbReference>
    <dbReference type="GeneID" id="119727294"/>
    <dbReference type="OMA" id="DSDCLMH"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="39365" checksum="096CAF4D608F09E6" modified="2023-02-22" version="1">MATAGFSKDYSNDQGKSECMGPTSLSYQLIDKESQIKPAIDDIGKGRETAGSLIAVDCEGQYLSRKGKLSVVSIATENQIYIFDIQALGESVFDKGLRDILDDYSRNKLMFDCREDSDCLMHQYNVKLVKVLDLQLLQIMEREATEDAGILEKQPLLESFLFCLVKYVKNEDLIKAKEEGDKKLPGTDAWLERPLSDVMLKYAACDVMGIFKLYSKLKHVCKGQALDRLRVASDSYLDIFRSLPSRSCDSRETSSHLPKNVIPSEFQLLFLPQSETECITCHKQFPYFDRNEQRGIPQLCQLCKLKINFGNLAHKALAMENDPYDSDDDDRPAWMKVGLGPNYKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVJ8</accession>
    <name>A0A913ZVJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038055698.1">
        <property type="nucleotide sequence ID" value="XM_038199770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055699.1">
        <property type="nucleotide sequence ID" value="XM_038199771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199770.1">
        <property type="protein sequence ID" value="XP_038055698.1"/>
        <property type="gene ID" value="LOC119727735"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199771.1">
        <property type="protein sequence ID" value="XP_038055699.1"/>
        <property type="gene ID" value="LOC119727735"/>
    </dbReference>
    <dbReference type="GeneID" id="119727735"/>
    <dbReference type="OMA" id="NAYYCDI"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324100" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="320"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="410" mass="46620" checksum="2FE5E9C4E781A9E4" modified="2023-02-22" version="1">MRTILLLVSVSLVMPAVYSLDNGLARTPPMGWNPWERFRCNVDCVNDPDNCIREELFIQMADIVAVGGYKDAGYEYINLDDCWMSKERDAQGLLQADPQRFPSGIKNLADYVHAKGLKLGVYQDMGTETCDGYPGIWGHIETDAKTYAEWGVDYVKMDGCHRLGPKLFPEGYKNMTLALNATGRPFVFSCEWGVYQPNPNYTDIAAHCNTMRNYIDIQDSWEQMLQVLDWYVSKQDEFYLVNGPGSFIDMDFLVVGDFQLSFAQAQAQMALWSIMSSQLIMSSDLRKMDPQMKEILLNHEVIAVNQDKLGKLGKRFYNKNQFQAWTKELDQGCYAAVILRRARNMPMNFTTTMEYLGFGSNTTYTVRDLFLHKDLGVFGPTDPLSVSVNPGGVVMIKATPKPIKKFVRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWV9</accession>
    <name>A0A913ZWV9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056004.1">
        <property type="nucleotide sequence ID" value="XM_038200076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200076.1">
        <property type="protein sequence ID" value="XP_038056004.1"/>
        <property type="gene ID" value="LOC119727995"/>
    </dbReference>
    <dbReference type="GeneID" id="119727995"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="640" mass="71494" checksum="CB3DE80B414110AA" modified="2023-02-22" version="1">MAEAAAKTVLDKISHGHLECPICCCLFKDPKMLDCLHSFCLNCLEEMMSKQKPEAEKITCPICRRGTQVPDGGLQSLSSSFFLSSLVDEVKQQEAVLGESSAPTTTCDCGEGKEATWRCLDCSDNLCQECWKAHGRLKHTKEHQIISLGDWQESKMPPAEHSKPITRMCTIHHDHPLCFYCDTCDTLICSMCAALDHRSAEHNFLKIDDLIRSFRSEVGNILQKFEKSRQHFKSTEKSIEHARKRLQKKVAQARSDIDAKAEAEITKIRNKAKLLTDKVNEIGQERDSEYEKALTHNHEQMERADQTIAAVNDLMSQADDFELLEFKPKVMHNLEYQKELKFEPANHGPSFIGVRCHDVVSDADLGEVCVSEKWQLKEEFGRQGTGDGEFQFATAVACFGNGDIVVTDTDLERLSLFSSTGRYKTSVAKGDLRHQLEAPVCIAVTHDDLLFVTDKKKVKVFDTEFYFVREFTPSADDVNGRSKSDLAAVAVDSQRVAVADRGRKVISVHNLDGSLIASISNSMVMIFSAISNFGCLVFTNFWDQSLQCVDFKGKEMFSVKTLMNGKAAKPAGVLSNDDETIYVTVHSGKRGGTEVQRYDSNGTFVATVAQRMHNPLGMAFTPTGDVIVADVYSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXN8</accession>
    <name>A0A913ZXN8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056269.1">
        <property type="nucleotide sequence ID" value="XM_038200341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXN8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200341.1">
        <property type="protein sequence ID" value="XP_038056269.1"/>
        <property type="gene ID" value="LOC119728206"/>
    </dbReference>
    <dbReference type="GeneID" id="119728206"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="215"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="666" mass="76290" checksum="2CDB1DA730EF61A0" modified="2023-02-22" version="1">MASDLLKQNQLRWDLSPEDIKKRADDLIKETKAVYDAVGGLEKDKVTYENTVLALANNDREYSVLRNMLDFPQHTAPDKALREASTEADKKLSDFDVEMSMRQDVFDNLVAFQEKTDLSKLKPEAKRYLEKLIKLGRRNGLHLPKDVQDKVKALKKRASDIAIDFNKNLNDENTILEFTEEELVGLPEDYIKRLEKTADGKCKVSLKYPDYFPAMRKGRNPETRRKLEFAFNSRCKNENTKIMEELVEIRQKLADLLGYPTHAAYILELRMAKTPETVASFLKELAGKLRVLQEAELKTFLSYKKEECEKYGYPFNNTIDLWDMRYYMNMAEERQYSIDHNKLKEYFPLEVVTKGLLEIYQELLGLKFEEIPKAPVWNDDVTMFSVTDKESGDFMGFFYLDLFPREGKFGHAACFGLQPGCLAADGSRQVAIAAMVANFTKPTADSPSLLTHDEVETFFHEFGHVMHDILGQTDFCYFSGTRVERDFVEAPSQMLENWCWQAESLRRMSGHHKDGTAIPDEMIDKLVKARNANAGVFNLRQILLGTFDQSIHTSAKADTTSVYAQISDDILGIPATPGTNMCASFGHLADGYDAQYYGYLWSEVYCMDMFYSRFKKEGIMDPKVGADYRKYILKPGGSIDAMDMLKNFLGREPQQEAFLISKGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYP8</accession>
    <name>A0A913ZYP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="2">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038056196.1">
        <property type="nucleotide sequence ID" value="XM_038200268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200268.1">
        <property type="protein sequence ID" value="XP_038056196.1"/>
        <property type="gene ID" value="LOC119728179"/>
    </dbReference>
    <dbReference type="GeneID" id="119728179"/>
    <dbReference type="CTD" id="60496"/>
    <dbReference type="OMA" id="WVFEESL"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="9">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="36281" checksum="198D9E9CC40F1DFE" modified="2023-02-22" version="1">MECQLCAYMCHMHCGCTVLVFAVCMMGSVRWAFRFGSWKPTQAEWTLASRCIQQEEKDKIGKFVFKKDGKASMAGRLLIRKVVAESLSYPWKEISLVRTDRGKPYLANENIADPDFFPNFNFNASHAGDYTVLAAEPEWLCGVDVMKVESRGTPSIPEFFRLMTRQLTPHEWEVIRAEDTEWKQLEMFYRFWCLKESYIKAIGIGLGLDLQTIEFHPNTKVLQKGVVTTDTKFHLNGKLDATWYFHESKLDDLHFACVALKRPDGVSADVHVPTTVFKELTFPDLVSSAQPLLPEDASYWEAFDKKEERPSGHDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZ27</accession>
    <name>A0A913ZZ27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056580.1">
        <property type="nucleotide sequence ID" value="XM_038200652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZ27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200652.1">
        <property type="protein sequence ID" value="XP_038056580.1"/>
        <property type="gene ID" value="LOC119728422"/>
    </dbReference>
    <dbReference type="GeneID" id="119728422"/>
    <dbReference type="OMA" id="ENRCAVA"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="289"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="849" mass="96119" checksum="3988A92779E74665" modified="2023-02-22" version="1">MGCCHSCRCRKSKSASEPEPASHYIYSNNPIPEKNHIPFTDMQMQLTGSQDLHIIPPANGNIKDGQSTIGSTKPRGSNVSLAKRSSAFYRLSKLGSDFSIGESIRTDGSTWTVASSINDQKEVDDPNYAADVLTKLNRFRHANKYTDFTIYVGNLTFRCHKVVLSATSRFFALNICDEVTEEGEVIIKHDMTLNDIRPDVVGLLLDYIYTARLMISGENVVDLLTAAQCFYLHSAEQACQEFLERQDNRSRNSITDSSKIMAEYTFEQPYHVNEILLGLNDQRFDNRFVDVTLCAGEEELPCHRVVLATVDSAMEERLQTADETGRVKITDVSAPVMRMIVNYTYTSKLEVCEENAKEALVLASTLRHESAVRKCSEFLKTMLDPANCLSIQRSASGPSCELLHKVATKFALKNFREVIKYEEFLDLSPQELVDYLGDDNLNLFSEEEAYKALIRWIKHDFEARKEHLPFALKSIRLPYASPKVLDAVAEDPLVKECEGCQDLILESRAIHILIRDGKQKSDPRMRPRKSFADVTFVIGGRNKNQQWIPDTSYYDNIRRKWFPLEPFPGSNTEYKVVALSNDVYVISGRFREGQLCGNVWRYNSLFDEWTEVASIHLPRVSHGVGVLQDLIYVVGGRVDKSNEPLQEVERYCRQTNQWKKSESMTYGVLDPVVTSHSRRLYVVGGLSEEGQVLVQCFHLDKNAWTVIKDVSLPFEPRFGATVKSKIYLVGGKTEYQVQVYNPNKGEDKMIGEMQHAEGHARELYSATVTNRKIDVTGGQWTVGTIEDALTIATNSVEQYDPLTNEWTVLGPMPRALTFHGCVTIKMYIGLPKGTDSWSSNKKSYQISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZB7</accession>
    <name>A0A913ZZB7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038056912.1">
        <property type="nucleotide sequence ID" value="XM_038200984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200984.1">
        <property type="protein sequence ID" value="XP_038056912.1"/>
        <property type="gene ID" value="LOC119728670"/>
    </dbReference>
    <dbReference type="GeneID" id="119728670"/>
    <dbReference type="CTD" id="10846"/>
    <dbReference type="OMA" id="ANTILLW"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000067">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="559"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="890"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="641"/>
            <end position="645"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114152" checksum="C35C8ACA88F7CF3E" modified="2023-02-22" version="1">MNRQRMSGPSKQAASRRLPPLPAHKRSPATTSPHASSKGHSVYLGPSPPSHTTGGKYAHIQGHYGYGIARSNHDRMIVTGQSSTLSNGIGRHRAVLTHPSFSESIEVLPDHILQEQVRSYLNENPAFLEDYVLSHVDYDILERWTGQVRAQKHKVTYSRSRSMSRENSGKSGSSQGTGPPSPKPHHWKKGVTLHDRKKLVHELTQDVQHYASRVRILQEMAKCVATQIQADGYTLYLLTETGTELYEYSAEHKGEEPSVTWPIGKGKSIAGYVAHSLHTVNTSEIRTADYPEGVVADGVTASAVLALPVLQANEDLVGVIEFYRDTNHGHGSFTEDAQETASAFLVWGCIAVHYAQMYVSMSKQRKLNDFLLTVTKSVFQDIISMDTVIMKIMNFAQKLVSADRASLFLVDNKTRELYARIFDVGNGIGMQVVEKEQKEIRFSMDKGVAGHVASTGQVLNIPDAYLDQRFNRDVDQQTGYVTKTILCMPIYNRGNVIGVVQMVNKKQGHFTKTDEQAFETFAVFCGLALHHAKLYDKIHRSEQKHKVALEVLSYHSQCHEEDLENLKKVALPDPMPQLARYDFSPWGLDEEAKPLYVLCMFQDMFTLNGDDHNDNSERFDYEDLCRFILTVRKNYRKVPYHNWTHAFSVAHSVYTIIKTCQEDTFTPVECLALFVACLCHDLDHRGKNNSFMVNNATPLAAVYSTSTMEHHHFNMTITILQNEGHNIFKHLTSDEYKQVLSDIRHAILATDLALFFGNKAKLKVIVEAGQFSWTNPEHRKLLKAIAMTACDLCAVCKPFEIQRQVANECFEEFYSQGDEEKAQGRNPIPMMDRSKSHELPTNQVSFIVGICLPCYDLLGQLVPSAKPMYDGAARNLQNWSAIVAKQKAEEEENLKQEELAKQEDQREDGDNAQEGPSASTTENKDTSKTAATAKSQTANTEQSKQADKSKDNQGRRRTASDANQRSTGHGGKEVAITATKTNPDTHEQTKVPNQESNTTGIQSSNDSKTSINGDHQVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZC7</accession>
    <name>A0A913ZZC7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 33A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056680.1">
        <property type="nucleotide sequence ID" value="XM_038200752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200752.1">
        <property type="protein sequence ID" value="XP_038056680.1"/>
        <property type="gene ID" value="LOC119728490"/>
    </dbReference>
    <dbReference type="GeneID" id="119728490"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.850:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1910:FF:000005">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71391" checksum="36CB3F484EB94C26" modified="2023-02-22" version="1">MATHLSGGRINLAVWREVARRELLECLDKCVGSKAIVWDDHLTGPFGLIAEYSLLKEHEVDKMFPLRPGRLPISAGSGQGSMIIQNIIFLVRPRLDLMEIVADAIRRTEEAAGRFHMEFHIFFVPRKSLMCEKKLTELGVYGTLTTVGEYTLDLLPFDSDVLSMEMEQSFKECYLQNDLTTMFYVAKALMKIQALYGIIPKIYGKGTLSKHVADTILRLRREMAGNERQVQPQIDTLLLIDRTVDLLTPLATQLTYEGLIDEIYGIHNTNVKLPPEKFVRKNENEPQQELPTEPKKIILNSSDELFAVIRDKNFNAVGPELSRKAKILSAQYEERKDAKTVRDIKQFVTKLPHIQAAKASLATHTSIAELVKERTDLESFMDSLQTQQEFMNGVDTDKVNNYIEECIAKREPLIKVLRLLCMQSVTNNGFKPKIYDFYKREITQTYGFEHIVSLNNLEKIGLLKVQGQKTYNTIRKTLRLVVEDVNEQNPHDISYVYSGYAPLSVRLAQFLAKPGWRSIEEVLRLIPGPTVEETQQIPYGLLKKRTIGDSQSDNQKVTLVFFIGGVTYAEMAALRFLSNQDDGPMEYLIATTQVINGHNWLRSIMEDLVVPTFSEKEFGSTTGSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZY6</accession>
    <name>A0A913ZZY6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Unc-50-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056636.1">
        <property type="nucleotide sequence ID" value="XM_038200708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200708.1">
        <property type="protein sequence ID" value="XP_038056636.1"/>
        <property type="gene ID" value="LOC119728454"/>
    </dbReference>
    <dbReference type="GeneID" id="119728454"/>
    <dbReference type="CTD" id="25972"/>
    <dbReference type="OMA" id="YRNFMYR"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31266" checksum="996C6FE67EA4859F" modified="2023-02-22" version="1">MLSSVIIAKSSPPNSPNGSRPTSPNPMLENRHTAQAKRRKFMRRILMFRQMDFEVAMWQMLYLLVAPQKVYRNFQYSKQTKDQWARDDPAFLVLLSICLGASSVGFAIVLRLGFLQFLKFLLWVVFVDCIGVGLLIATILWFVANRYLRVSVPIRQDVEWGFAFDVHLNAFFPLLIILHVVQLFLYIPLIDGNGFLSTLLGNTLWLIAITYYIYVTFLGYSALPFLKRTVAFLYPPCLIVLCLYVITLIANWNITRNVMFFYEYRVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A080</accession>
    <name>A0A914A080_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057232.1">
        <property type="nucleotide sequence ID" value="XM_038201304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A080"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201304.1">
        <property type="protein sequence ID" value="XP_038057232.1"/>
        <property type="gene ID" value="LOC119728872"/>
    </dbReference>
    <dbReference type="GeneID" id="119728872"/>
    <dbReference type="OMA" id="LYHANCV"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="37191" checksum="4B1B3794CCDE1BB8" modified="2023-02-22" version="1">METTWPPNKGIIVTSNSTENNIENEHTSTTLVILVAVLAVLAVFLCVLLNPLMLFTLRRVTSIQPTTKIFMASLTLSDLCNNLYWILVLTELFAGSWLLGDFLCVVYGVTSYLFVSLSIFSLFILTVDRYIAISQPLQYPSIMTVFRSKIIVFSSWAAVSIFCILIFGIDGSRIVSLDTRYYLCIGHYDWRNYLAVLLAVVIILSIFILYARIALIARKQARRISAENQAGNGQGGQRINTRSTTTIIIITGTLIITWIPTVVRLLIVIPSPQHTWTQYLAGTFTNVLLLCNGWLNVMIYYLRNRDLRQAVRALLSDWHQSLQQRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0Y2</accession>
    <name>A0A914A0Y2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type IV membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus membrane</location>
            <topology evidence="17">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057319.1">
        <property type="nucleotide sequence ID" value="XM_038201391.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201391.1">
        <property type="protein sequence ID" value="XP_038057319.1"/>
        <property type="gene ID" value="LOC119728943"/>
    </dbReference>
    <dbReference type="GeneID" id="119728943"/>
    <dbReference type="OMA" id="LEHESHE"/>
    <dbReference type="OrthoDB" id="10016565at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21189">
        <property type="entry name" value="CH_PLEC-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="56"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000008">
        <property type="entry name" value="microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000099">
        <property type="entry name" value="Nuclear anchorage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000048">
        <property type="entry name" value="Short stop, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="103"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="53"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01129">
        <property type="entry name" value="DELLA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="119"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="99"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="22">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="22">
        <location>
            <begin position="143"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="840"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="15568"/>
            <end position="15603"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="15604"/>
            <end position="15639"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="24">
        <location>
            <begin position="15648"/>
            <end position="15720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="254"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="972"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1057"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="5130"/>
            <end position="5151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="6823"/>
            <end position="6854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="7669"/>
            <end position="7726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="8493"/>
            <end position="8517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="8553"/>
            <end position="8572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="10267"/>
            <end position="10286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="11114"/>
            <end position="11141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="11950"/>
            <end position="11980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="12831"/>
            <end position="12852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="14380"/>
            <end position="14399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="15239"/>
            <end position="15264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="15453"/>
            <end position="15516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="15744"/>
            <end position="15846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="15875"/>
            <end position="15921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="580"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1869"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="2080"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="2222"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="2995"/>
            <end position="3022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3582"/>
            <end position="3630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="4434"/>
            <end position="4482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="4938"/>
            <end position="4965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="5404"/>
            <end position="5431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="6153"/>
            <end position="6197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="6972"/>
            <end position="6999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="7357"/>
            <end position="7384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="7854"/>
            <end position="7884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="8719"/>
            <end position="8752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="9079"/>
            <end position="9123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="9575"/>
            <end position="9602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="9712"/>
            <end position="9739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="10291"/>
            <end position="10318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="11252"/>
            <end position="11321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="11520"/>
            <end position="11554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="12127"/>
            <end position="12154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="12271"/>
            <end position="12323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="13038"/>
            <end position="13065"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="13910"/>
            <end position="13980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="14457"/>
            <end position="14484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="14568"/>
            <end position="14595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="14949"/>
            <end position="14976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="15391"/>
            <end position="15432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1277"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="6835"/>
            <end position="6853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="7698"/>
            <end position="7726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="8553"/>
            <end position="8565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="10275"/>
            <end position="10286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="12833"/>
            <end position="12847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="15242"/>
            <end position="15251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="15252"/>
            <end position="15264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="15757"/>
            <end position="15772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="15791"/>
            <end position="15808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="15896"/>
            <end position="15921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="15921" mass="1838618" checksum="8234AB4674AC5581" modified="2023-02-22" version="1">[encoded data, 15921 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2B9</accession>
    <name>A0A914A2B9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057764.1">
        <property type="nucleotide sequence ID" value="XM_038201836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2B9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201836.1">
        <property type="protein sequence ID" value="XP_038057764.1"/>
        <property type="gene ID" value="LOC119729248"/>
    </dbReference>
    <dbReference type="GeneID" id="119729248"/>
    <dbReference type="OMA" id="NDFSMEV"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037218098" description="Sushi domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22316" checksum="E348506135CD41E2" modified="2023-02-22" version="1">MERHCQAAILHVLILLYVSVVSSSCPPPPKQLGTNCSDETIVNFQVNYKITCTCMFGYNPVGDLTRTCTESSTWTGSDDICRIDAVSVALACFAGLAAILIFTTLSCCLISRDRRRRRRAERRLTIQRREEEAANAGLNGPAQQEPDHYTRTPSTKERSDSGLQTDLDMEDIDFNDFSMEVDSPTDNNPPEGLNLDFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3G4</accession>
    <name>A0A914A3G4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058382.1">
        <property type="nucleotide sequence ID" value="XM_038202454.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202454.1">
        <property type="protein sequence ID" value="XP_038058382.1"/>
        <property type="gene ID" value="LOC119729736"/>
    </dbReference>
    <dbReference type="GeneID" id="119729736"/>
    <dbReference type="CTD" id="5125"/>
    <dbReference type="OMA" id="DEDTNDC"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008038">
        <property type="term" value="P:neuron recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.850:FF:000001">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF3">
        <property type="entry name" value="FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036917987" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="24"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1795"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="439"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1847"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1855"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1868" mass="205561" checksum="4C9DC4A3F530D6CD" modified="2023-02-22" version="1">MMNTHLITSVLLLLHFGGTGVHSTFTNEFISNIEGGPEVADNLAASYGYINFGEIENFPDHYVFHHLATEKRSIRPSRGDHTAIKHEAAVNWIEQQKIRKRVKRGVERINDPKYPQQWYMNRKDAPNMNVEPAWEMGYTGKGIVVSILDDGIDYTHPDLAKNYDPLASCDINSHDDDPMPSANYDQTNRHGTRCAGEVAMEAGNNICGVGVAYNASIGGIRMLDDQVTDRVEGSSLAARRNHIDIYSASWGPEDNGMTVDGPGRLAKKAFHDGIKKGRGGKGNIFVWASGNGGRAKDNCGCDGYTNSIYTISVSSTSERGEAPWYLEECASTLATTYSSGSPKEKKVITTDLGGRCTDDHTGTSASAPLAAGLCALALQSNSNMTWRDMQYVIVMTSHNNSLNDGGWLVNGAGYSFSHRYGFGLMDAGAMVQLARNWINLPEQLSCEISLISSSREIKGRGMLATFTLNTTACENGPIYLEHVQSTVDVTFGSRGALVLTLVSPSGTHSKLLGIRPKDRRKGSFSSWPFMSTHFWGERAKGVWTLQVENGLPKSNSGQFRGWVLTLCGTDSLPTTATPPKKPAIRQGSKSPIKEMIDDVDHSRVAIPRSSDYSPCHPECFNSCSGPLASDCWKCLHYRDRKTDECITHCPDGYYDPPEVHTRCKACAPTCLTCAGPSYSDCLSCRNPFFLMESWSECVQVCDQKFYEDIETNTCIQCAPLCSKCEGSPNYCSACEPHALLSSDNTCLSTCSTNEYLEGSACHPCDSTCHTCSGSQDNDCLSCVPGSVLKERTCVEEWRCTDGYYVERGSLGNGKECLRCHVSCKNCKGQSSSECTECNTGDILQDGACIKNCLAGYFKDSNDDCLTCSYGCDHCTEEDNCVQCQSEFVLVDGTCKQGCIDGSYEHEGSCLSCHSLCETCIGGGPKDCTSCKLMEADLRYLLEGACVPFCPEGQYEDQQTLKCEECDETCRTCSGSEVNNCQSCYDGFLLNGDVCQEQEGKYCDPKCKECMYGSEDRCSSCNDGKYLQEFECVDNCAAGYFADEIGTRDECVRCNPSCKTCSGASSQDCTSCNENRFLYDSSTCDSHCPYTTYVDRSDGTCKDCHSTCQSCSGPGSDACETCEGNLFWSDNECVSACPNSTYGDEGEQQCMKCYPTCKTCDGPLSENCLTCIAGLKLTGSICKQGDCPHRTYKDGDVCNDCHDTCQTCKGPEADDCQMCDYDRFLNEENQCIEVCNPGYYPDYENNICRPCHSSCKTCVMEGPQDCMDCENGMYILSNEDGVFCVNHCPEGFYVLEEGPDDDRSLTCQMCSPQCLDCSSSYSHCISCRDNTFLFRDQCIPSCPGGFMEDVESNRCLVEDRICPLHCTSCNEWGECLACKGGYQIYYGECMQPASQCAEYKYRAVDSSGNTLCRDCIAHCKRCLGPRPDECLACDTDYQLNNGHCRQNCNAKQFDQDGVCVACHPSCETCEGPSPYECTACPEGMVHTTSNSNLGECSIGCPEGTFRDQNQCLACHDTCQNCDGNSQDNCLSCKPHFFLTGNQRCVQTCPDGTYHYLTDDDSGSPSEFECRPCHSSCNTCYGPLERECTTCHDSMYRLDHECVAHCGTGNYPGKQSVCQPCHFDCISCWGNGDNQCITCANGKKLLDGLCVDECPLDHYLSLDFGAVCKPCHVRCKTCYDMGPFNCLSCHEGYELEDNVCYSRCDLGTYYINHTQHCMPCDPKCQECYGATDKHCIACHSGQSLSKVDDEHYTCLSCCKEGLDEANCCQCNKDEQCMELQGNDNSEQPVVGPKLNHGAIVFVCFLVLAVFGLFFGLLQARSRKKLCWKNTYEQLPAFYSNKGEQPKITLRQNALPSSDEDDYFDDSEGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4G4</accession>
    <name>A0A914A4G4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058269.1">
        <property type="nucleotide sequence ID" value="XM_038202341.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058271.1">
        <property type="nucleotide sequence ID" value="XM_038202343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4G4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202341.1">
        <property type="protein sequence ID" value="XP_038058269.1"/>
        <property type="gene ID" value="LOC119729672"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202343.1">
        <property type="protein sequence ID" value="XP_038058271.1"/>
        <property type="gene ID" value="LOC119729672"/>
    </dbReference>
    <dbReference type="GeneID" id="119729672"/>
    <dbReference type="CTD" id="23621"/>
    <dbReference type="OMA" id="VLMEAFY"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000003">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000007">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009119">
        <property type="entry name" value="BACE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009120">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01816">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01815">
        <property type="entry name" value="BACEFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275676" description="Peptidase A1 domain-containing protein" evidence="16">
        <location>
            <begin position="29"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="75"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="530" mass="58914" checksum="7FAE0C509CC68764" modified="2023-02-22" version="1">MADLATVVNLWWTLLLLHVCMHSVVVRAEILRLPLHTAVRRVNDGVRSRVGERSHNVLRRSAPRDNIGGKPGLGFYVEIELGTPKQKLNVLVDTGSSNFAVAASPNSLITKYFHKDQSQTYRDLNRKVYVPYTQGEWRGELGEDVATIPTSHPNISVTVNVVSITYSEEFFLNESNWQGILGLAYADIARPDDTVEPFFASLVDQTDVANIFTLQLCGVPENVVHTGTTDVTGTMTIGGIDPGLYTGKMWYTPIRNDWYYEVIIMDIEVGDQSLGMDCKEYNFDKTIVDSGTTNLRLPARVFDKLTSLIYTALTKKMENVTIPTDFWSGADMICKEGTVEEPWVKFPTLSIILNGTEPGTGFRLRISPKQYLRHVETSNKKETCYKFGVASSDSGSVIGAVVMEGFYVVFDRENQTVGFAKSSCAYEFEFATPAPEVEGPIREVATDCGYVAPDNNNLALTIAAYVLAGLCVLCLTPLAFLYVYYRCRLCFANTTKNDDSELLEDRTDSSETDALREEAQQGEPQQGQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4W6</accession>
    <name>A0A914A4W6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058435.1">
        <property type="nucleotide sequence ID" value="XM_038202507.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058436.1">
        <property type="nucleotide sequence ID" value="XM_038202508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202507.1">
        <property type="protein sequence ID" value="XP_038058435.1"/>
        <property type="gene ID" value="LOC119729767"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202508.1">
        <property type="protein sequence ID" value="XP_038058436.1"/>
        <property type="gene ID" value="LOC119729767"/>
    </dbReference>
    <dbReference type="GeneID" id="119729767"/>
    <dbReference type="OMA" id="QTSTCIF"/>
    <dbReference type="OrthoDB" id="10364855at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275665" evidence="2">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="121" mass="13257" checksum="28B9D7E3CED6DB3E" modified="2023-02-22" version="1">MGTNVCVLALLLMACVAAVTCTNARPRRGCDTLCKLKSLTHQAGKRTKSVDRNQGSYPWNQGDTSPTYTADDMTKDPKSTCIFDEALKRISPKWQERLLSVLEGALMETKGKEVDDGSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A559</accession>
    <name>A0A914A559_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058664.1">
        <property type="nucleotide sequence ID" value="XM_038202736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A559"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202736.1">
        <property type="protein sequence ID" value="XP_038058664.1"/>
        <property type="gene ID" value="LOC119729946"/>
    </dbReference>
    <dbReference type="GeneID" id="119729946"/>
    <dbReference type="OMA" id="LAPTENC"/>
    <dbReference type="OrthoDB" id="7940501at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="23963" checksum="D4CA02B9A15C5A72" modified="2023-02-22" version="1">MSRLGVYTIYPPQYPNGLTVYCRGQWIVIQNRKRGSVNFTRSWAEYRDGFGDLTGEFWLGNEVVRQLTSEGTWKLQIIVEEAKGLKRITWTQFKITGDNYTLHVDPLQPGDLHYSKGKSLTDVSLGQPFSTYDRNNDADGNANCAAQLKGGWWFKTCTGGVGNVDLVPTNLNGEYSYPVNYTGQDYRGMRWAGALEFGDQILSCRIAICTCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5W9</accession>
    <name>A0A914A5W9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058801.1">
        <property type="nucleotide sequence ID" value="XM_038202873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5W9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202873.1">
        <property type="protein sequence ID" value="XP_038058801.1"/>
        <property type="gene ID" value="LOC119730087"/>
    </dbReference>
    <dbReference type="GeneID" id="119730087"/>
    <dbReference type="OMA" id="WRTNGSI"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="548"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="889"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1257" mass="138948" checksum="C2F21CC6726DCDD6" modified="2023-02-22" version="1">MEQAPAGSSNSTISYSFSGSGPSGGEKHASPPPPPTSNSKKRGCFYLHLDLSFNNISILPADAFRHLPRLDTLILIGNRLSTLDKNVFRGLRNLDTLNLKLNRFQQVPRKAFRNDDLANLRKLHLDSNWIRDVPADAFMNLTALHHLNLDHNQLSEVPTAALHHLSNLRILHLEYNSIPVVPDHAFAENSHLMELILRHNKITHLSAHAFAGLPNLWVLEFLGNSITSIAHTAFRNLPALQNLIISEVKNLSVFPDLTGTTSLEHLGIERCSLRAIPANFCDNMTGLTSLNLHNNLIEGLPSLAKCSSLEVLHLGTNKLTSLEGQPFSGLHDLYDLQLKENDISYIPADAFQSLSHLDTLSLNNNTIREIDSQAFASCTSLQYLDLSNNSFPVLPTAGLQMLLKIRTYDNEQLEDFPPPSELPSITEIATAYPYHCCEYIELAEEYLQSLADRPNISETTYWASGSVPDYYNMTFDINSDSWIDSSPGFGSLFIGSQTWLNGNYSRLLVPHNISCRPKPGPFMPCVDLFGSWPLRIGVWLVFLLAIIGNAIVIFVIIVSHTKMDVPRFLICNLAFADFFLGVYLGFLAGVDTSTLGVFRKFGARWQLSAGCRLAGFLAVFSSEFSIYTLSVITLERFYAIKHALHLEKRMKLPHAITVMCFGWIFSVTAAVLPLVNVSHYHRFPVCLPFDVDTTVAKVYVGSILILNILAFVIIMACYASIYLAIQGSHAWNCNDSRVARRMSLLVFTDFACWAPIAFFSLTAAFGLRLISLDGAKVLTIFVLPLNSCANPFLYTILTKQFKKDCKTIMRSLSNRVFRQRSMSRSITLSLGRHPSMRSTQAHQTSQLRWRTNGSISQDLTGDPCLVSFKTENAETSNVYTVSNFSSLADPRATETSNTNGSCSHDHSHSDSSTMLDPNTSNQTLADPRRGSRSPLLDLVAHVRGKTHDYKPKAKTRRKFSIPIPFFSNRSPNKTPAGDSGQPSPARSSPLGHRHKRSHSVTEGLLHKMGRKKPLTSVLSAPGVTSPISKSSERLHQGNSVHSGAIRIIIPQSENPGKDSTSATSAEDGDLQHQIRALQDPWNPSSTLFRSQKGPDQMEAQCLLDSPRSFNDPNSSKDEASEDISEAERLLRSSHDNPVRDQLSSANPSPLLHRPQELELVTVPATGSDNPDCDSGLGTASSPFPDSTEYMKFLPESPHKLNSGEICAAEPDSQKTKSQGLGSLLVHLTRSEQNNSYNEVPSSPSKSDILCKPRESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6X3</accession>
    <name>A0A914A6X3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="3 7">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_038059166.1">
        <property type="nucleotide sequence ID" value="XM_038203238.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203238.1">
        <property type="protein sequence ID" value="XP_038059166.1"/>
        <property type="gene ID" value="LOC119730374"/>
    </dbReference>
    <dbReference type="GeneID" id="119730374"/>
    <dbReference type="OMA" id="FHQSTDK"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000021">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="361" mass="38915" checksum="C4F80FF3EE2C41D7" modified="2023-02-22" version="1">MSQYLTIEQKAELVDTANKIVAPGXGILAADESTGTMGKRLANIGVENTDENRRLYRQLLFTTDPAIGKNISGVILFHETLYQKADDGTPFVDLIKQRGIIPGIKVDKGVVPLAGFNAGECTTQGMDDLGARCAKYYQDGARFAKWRCVLKITDLTPSDAAMRENAHILARYASICQQNGLVPIVEPEVLSDGSHNLARCQFVTEKVLSYCYRALNDNHVFLEGTLLKPNMVMPGQSCPVKYTPEQVGQATVITLQRTVPPAMPGVTFLSGGQSEEEASLHLNAINACPGKKPWALTFSYGRALQASVLQAWKGKPENVKAAQDELLRRAQANGAASQGKYGGGATGAAGGKSLFVADHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A746</accession>
    <name>A0A914A746_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intraflagellar transport protein 22 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rab-like protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059241.1">
        <property type="nucleotide sequence ID" value="XM_038203313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A746"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203313.1">
        <property type="protein sequence ID" value="XP_038059241.1"/>
        <property type="gene ID" value="LOC119730427"/>
    </dbReference>
    <dbReference type="GeneID" id="119730427"/>
    <dbReference type="CTD" id="64792"/>
    <dbReference type="OMA" id="NERHDQE"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001100">
        <property type="entry name" value="intraflagellar transport protein 22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="186" mass="20724" checksum="C9040541FF5BA39A" modified="2023-02-22" version="1">MLKAKILVVGPCESGKSVISNFLADATETSGGEYHPTQGVRILEFESGSNQMGARSSTAEVELWDCSGDQKFDECWPAIMKDANGVVIVYNPDVPTHERELDMWYSHFVVQQALREAQCLIMGHHKPSAKSSSTVEIPSSMSKVHHIQTNLEEDAEGIRREFNRFLGKLLGGMSRKQDQEELSIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A753</accession>
    <name>A0A914A753_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059600.1">
        <property type="nucleotide sequence ID" value="XM_038203672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A753"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203672.1">
        <property type="protein sequence ID" value="XP_038059600.1"/>
        <property type="gene ID" value="LOC119730682"/>
    </dbReference>
    <dbReference type="GeneID" id="119730682"/>
    <dbReference type="OMA" id="FMHLEVF"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19340">
        <property type="entry name" value="Wnt_Wnt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000003">
        <property type="entry name" value="Protein Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013301">
        <property type="entry name" value="Wnt8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF81">
        <property type="entry name" value="WNT INHIBITOR OF DORSAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01892">
        <property type="entry name" value="WNT8PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037495126" description="Protein Wnt" evidence="11">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="344" mass="37825" checksum="20E8F9A75198ED97" modified="2023-02-22" version="1">MLVQCMILHSLMMVAGGQLLARGWAPASNLLLSGSKGLQRYISYSDSVSAGAATAMKECRHRFQWDRWNCPEGSLALFNEPLPTREMSFVHAISSAGVMYSLTKNCSVGQFENCGCDESKRGGKTGGEDWKWGGCSDNIKFGEKIAKVFVDGMEQGQDALALMNLHNNDIGRKAVRQTLTRRCKCHGVSGSCSIQTCWDQLGAFGIIGEALRKRYETAVLVDYVSGGLHPNEKKAQEDRAETQNDLVFLQPSPNYCHVNSTVGTAGTLGRECLRGRGTEVTAWEARSCKRLCSSCGLAVQRSKVVVSSSCNCKFHWCCEVRCETCTREVTKLTCARKSESRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7R1</accession>
    <name>A0A914A7R1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059830.1">
        <property type="nucleotide sequence ID" value="XM_038203902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7R1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203902.1">
        <property type="protein sequence ID" value="XP_038059830.1"/>
        <property type="gene ID" value="LOC119730849"/>
    </dbReference>
    <dbReference type="GeneID" id="119730849"/>
    <dbReference type="OMA" id="SAGAPKC"/>
    <dbReference type="OrthoDB" id="6084362at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037999984" evidence="1">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="223" mass="24175" checksum="590335F005E05B40" modified="2023-02-22" version="1">MSAKTIVFLFLVALATSHAQAPAGPCCYPDQFVIAYGSQSGISHFGTAAAIGIFANSAFDFTNKMIGEEGTLVVEGQPPKDYKVIQDYAQGVQYTIDRGESKCDKTKLAGPMQHCVPGGAIFNATAYLGDKKLNIDSYYYVILTPQQQGRLALSVTQGDCLPNSYSFTGKAGPTSILTVTGYFNYVQGIADPSAFFDVPDYCPSYITAESELLKQLKYQRVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A956</accession>
    <name>A0A914A956_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060375.1">
        <property type="nucleotide sequence ID" value="XM_038204447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A956"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204447.1">
        <property type="protein sequence ID" value="XP_038060375.1"/>
        <property type="gene ID" value="LOC119731301"/>
    </dbReference>
    <dbReference type="GeneID" id="119731301"/>
    <dbReference type="OMA" id="CIINIVV"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038057126" description="HYR domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="349"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="46863" checksum="D31F7CFDC92B5581" modified="2023-02-22" version="1">MDLKTLIIASLILLLLIAPAESMWRRRRRRRSPPPSGPGLAAKTPPLRTRLLQDVDSPDLNCPSASTVYAERGSTAAQVNFQVTASDNSGQQPTVTCDPESGQFDLGQYLVSCIASDPAGNAATCSFQIEIVERTCTALPIPAYGDYIGDCCHVYGCVCSLKCINGYQLIGSRQASCEFNGTSTYWQQDDTPHCQLITCEALSLPDAVQVTPSICTAGRPLAGTLCFFFCPRGLSLVGSVSQVSCGGEGLWDVEAGNLPTDCEDRIPPVLTFCPGPIYATRGGEAGVSVTFDIPTARDNNLSGTLTLETSPSGITSPHSFSESTEVSYTFTDEGGNSVTCTFRVYVLDDLEPEVIYCPDDYAITARDILTQVTWDEPIFRDPLGHDLVVSNNVAEGHTAILPWGRHTVVYTTINTDNGQKAACQFAIDITREQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9A0</accession>
    <name>A0A914A9A0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras GTPase-activating protein-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060422.1">
        <property type="nucleotide sequence ID" value="XM_038204494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9A0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204494.1">
        <property type="protein sequence ID" value="XP_038060422.1"/>
        <property type="gene ID" value="LOC119731334"/>
    </dbReference>
    <dbReference type="GeneID" id="119731334"/>
    <dbReference type="OMA" id="YGQMDIN"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000010">
        <property type="entry name" value="Ras GTPase-activating protein-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="55863" checksum="E3A8FBD0FF41AD43" modified="2023-02-22" version="1">MVMATNPQSAPSAAPAGAQRTAAPNTSDANIAGNNAVVSPESVGREFVRQYYTLLNRGPEHLHRFYLNNSSFVHGGVDPDGNPEEPVYGQMDINEKILSLNFRDCHAKIRQVDSHATLGEGVVVQVTGELSNNGEPMRRFMQTFVLAPQSAKKYYVRNDIFRYQDEVFNDTDSEPENDGCGSVSEGEEATAEQPISTDISVQDATVSSYYEPHQPVVSNGTAHLESPETTPTKPAEISDPVGMEITQESPPTISEEVAQPPAPAMDNHEQEPEEEQPEPEEPVDKGPKVPSWADKARNVPTAASTPPSSNYPSMQTQPVPNQKPSEPSAQASNPGGPPRGGGMEPLPQREPRRDRDREGQRDLRGRPTGGRRPMEGPEQGNRPRAPQNPDSHQLFVGNLPQDVNDEELREFFSTFGTVLDMRINRNTGPKPLPYFGFIVFSDRLPVQTILKQKTKGPILLRGEHRLNVEEKKTKRPGSGGPPRGGASGRGGPRGGMGGGINKGGGPGRGYNPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAA4</accession>
    <name>A0A914AAA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060319.1">
        <property type="nucleotide sequence ID" value="XM_038204391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204391.1">
        <property type="protein sequence ID" value="XP_038060319.1"/>
        <property type="gene ID" value="LOC119731261"/>
    </dbReference>
    <dbReference type="GeneID" id="119731261"/>
    <dbReference type="OMA" id="HHTRAAM"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="46"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="150"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="361" mass="39518" checksum="645EE510E787371C" modified="2023-02-22" version="1">MRLISFAASAKTLLQKTSLQKSSVSCLFFEKIISRTMSDQPRWKIYVTRRLLPEALDLLKEKCDIEIWDHDNVVPRDELLKRIAGKEGMLCQLTEKINKELLDAAGPSLRVVSSMSVGYDHVELQQLKERNVLLGNTPGVLTDATAELTVALLLTTSRRLVEGTHHVKNGTWGSWKATWMCGPGLSGSTVGLVGFGRIGQAIGQRLKPFGVKRFLYCGHTPKPEAPMLPAEFVSQDELLQQSDFVVVCCALTPETRGMFNSAVFKKMKKSAVFINTSRGAVVNQEDLVEALESGTIALAGLDVTTPEPLPVDHPLLKLTNCVVLPHIGSATLETRTAMAMLSAENLLTALEGKPMPAQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAL5</accession>
    <name>A0A914AAL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060808.1">
        <property type="nucleotide sequence ID" value="XM_038204880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204880.1">
        <property type="protein sequence ID" value="XP_038060808.1"/>
        <property type="gene ID" value="LOC119731672"/>
    </dbReference>
    <dbReference type="GeneID" id="119731672"/>
    <dbReference type="OMA" id="ENCTWAD"/>
    <dbReference type="OrthoDB" id="6021576at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="57"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="345" mass="38878" checksum="4B807FC90FD0334C" modified="2023-02-22" version="1">MNFSAGEMADNCSDSTGAENCTWADPTGLVPSYPDITGWLQFSITTQFLLIFVIFFTNATVLVLVAYFKTLQVLENSFIVSLAAADGLLSVAMIPGVDITLNPTRAGNKYACLLLWCSIMFSSSASVFSLLALSLDRYLKIVYPLHQYMTAARVCGILAFVWSYTFITAFVLPFVGLNGIKDPFFVCFDFKDVFNIAHLQFYCYINGLAPFLFMFVMYGKIFRVVWEKLRAESDQIPAGAEGVGRSKQWLRRELKVIKKLTMVLGTTAVSWIPTTCMLLRQIYDPTYYPTFQTRVILSTLTYMNSAVNPLLYSLRIQPFREALSKVFCRRCQRPNAIHPSGRDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AB13</accession>
    <name>A0A914AB13_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060636.1">
        <property type="nucleotide sequence ID" value="XM_038204708.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204708.1">
        <property type="protein sequence ID" value="XP_038060636.1"/>
        <property type="gene ID" value="LOC119731535"/>
    </dbReference>
    <dbReference type="GeneID" id="119731535"/>
    <dbReference type="OMA" id="SAWTACN"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF278">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="19">
        <location>
            <begin position="2474"/>
            <end position="2675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1439"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1463"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1486"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1517"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2677" mass="296620" checksum="FB09409B81A410D8" modified="2023-02-22" version="1">MHQRISKSIKQDSNSSKTASSTQTESSHRREKRFVSLTRHVELMVVADSKMLNHHGANLEHYLLTLVALVNKIFKDPSIGNDINIVLVKLLVLRREEENLSITSDAPQTLRNFCAWQQDQNQKEESHPHHYDTAVLITKEDICRSAFDCDTLGLAELGTMCDPFRSCSIVQDNGLSAAFTMAHEVGHVFNLPHDDNTRCQEFSENLSGKYGVMAPTLNYQINPWTWSLCSKNKITDYLDMGYGQCLLDSPTDAQILPSYQPGEVYNVTKQCELVFGEGSTVCPIMKTCNRLWCTGSSQGSRRGCRTQHMPWADGTPCGHNKWCDRGKCISRRHHSLASVDGGWGKWEPYGQCSRTCGGGVRQAIRQCTQPVPQNGGKYCIGRRARFGSCNSRPCPDGSIPFREEQCAAYNGNNFNIQGVPRDVRWVAKYTGVQIKDQCSLFCRVEGSIAFYKLAKKVVDGTPCGPDTSDICVQGQCWQAGCDHILGSKTTRDDCGVCGGDHQACTTITDTYNEAHYGYNKVVEIPAGSTKLDIQQRSPPGAPEDDNYLAIKNTNGEFLLNGHFVVSMFQREIKIGNVVMKYSGSNNSTEKITCYEKITSSITIYVLSVGNVVPPDILYSYNIPIPGKDIYVWDMYGPWGSCNKMCKGEKEQGLRCLRQSDRLQVKDSHCRGGRPDPFTSKCNTGCELRWVITAESDCSATCGRGRRTRRVQCKKSGGRRRISMVVADANCNDQARPAEVVECGSECEAAHWEYSAWSQCSRSCNSGTRRRSASCRDSSGYYTQDSNCDSSTKLVVERCNTQACPIWAAESWSECSVTCGSGEMQRSVRCYQGNQIVDLTQCDLTMMPETATPCQMEECAVWHQGEWGPCSATCGQGSMQRLVSCMVGDQQTEVTRCDLSLMPDTTRSCQAADCPFWHQGEWNSCSVSCGQGEKLRLVSCYQGNYVVDSSRCDRSQMPESMVPCDAGECAKWLASDWGPCSVTCGHGERQRRVSCFQGNQKVDVSHCVLDEKPESVSPCRMEACAAWQHGEWEECSVTCGQGTQLRKVSCYRGNQVVHDNECSQTSAPTTRVCHMIDCAIWKHGDWGECSGTCGEGEKQRFVGCYQGNREVEAHQCDQASKPDSVTSCEMAECPLWHQGEWGPCSASCGDGEQQRAVACYQGDHVVDISQCDLTLMPESVTSCKLTECAYWQHGQWGPCSVTCDEGEKRRSVNCYQDNQIVDASQCDASILPDTVMVCQMVECPAWKGEDWDPCSVTCGQGTRQRTVNCYQGNLKVDINLCDPTMMLETTLPCELIECTDWYQGEWGPCSVSCGSGEMQRRVSCSQGGRNVDMVNCDLTSMPETVTGCQKPECPEWQAGQWGQCSTTCGQGMMQRQVDCYQGNSIVDLSQCDLTLMPASSRDCEPGQCPVWRHGSWGPCSVSCGLGYQLRGIQCRHPNDTPVPDDQCSPDDQPPNRQECRTPACPAPTLPATDPPETQPPVKPAPTVPATTAAAPVPAVLRRPSALTPRQSPRPPRPSSSQRAIADPSSSSSSTISVARKPSDPRPLPKSSPVTAMEVLREEPRRRYSSQWRTGMWTECSTTCGYGTRERYVSCRDRYGYISEERDCNTANRPAAIEQCQIKPCPHWRTGQWNRCSVTCGQGTTSRYVACVNGDSSIAVDEDCDLRDKPSETDVCSRLDCPVDQPVASGMASERASALLRGRWRTGQWSKCSSTCGSGLRQRIVICQDETGDVQTCSEKNRPQNIEACNTGIACPLWSFGEWGQCSATCGGGIRSRLVLCRLRSGRTLSDSSCNLLSRPENTRICSANPCPTRHSWRTRPWSWCSVTCGTGTQQRSVTCEDEAGAVKEDEECGMEGAEKPASERECLEQECPSAPAWKVGDWSECSVSCGTGTQLRSVTCQDEAGILQQGEECHLEGAEKPATERVCREQECPSGLAWKVGAWSECSVTCGVGSRQRTVTCEDETGIPTQEEECEMEESDKPETGMECRQADCSRPTWRAGDWKECSVTCGTGSQDRTVTCEDETGDEVPADNCEVGESTKPDIQRECHLMECPRLKWNVEDWNHCSVTCGVGFRERRVVCVDEVGNEIEDKECETNETIKPASRRDCRQVECPPSRPGWSVGDWSKCSVTCGSGTRERTVTCQDHTGTSKQEGCEVDGMPRPATHTGCQQADCPRLRPRWTVGDWSECSVTCGKGSRRRTLRCEDQSGQQREEEECEENGSARPASVKECRLRTCPRPTWIVTKWSDCSVTCDKGVRVREAACQLEDEVVEESLCLRKKPKTSKKCRRDKCMKYRWKKGRWSQCSKSCGGGHKLRKVHCTDSKDNEVDNSLCSSQSMPRDNNKCNTHDCDAPRLMWLAGPWGECSKTCGPGQETRSVTCRAFSPDGWAMPTDDKTCRQDSKPKDTRPCFIGLCSSDSHWRMGPWSMCSKECGGGIKERKVQCRDRQGKRQPASSCGPPTIRPETRDVCNHEPCQPESCRDIQLQRNLHEDADYSILVQGKPLTVYCHGMTTDAPTEYISLSAGEGENFAEIYPKRLMRATHCPYHGNRNDDCECTDDGHREAGLTTFTKLRLNITNMEIIISDPTFAVVHRGKFVPYATAGDCYSSADCPQGQFHINLTGTRLALAPEVDWGTEGYAVSRRLSRDELNQRVAGRCGGFCGTCFPDKKRGGLRVTFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABK0</accession>
    <name>A0A914ABK0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase/reductase SDR family member 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060830.1">
        <property type="nucleotide sequence ID" value="XM_038204902.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060831.1">
        <property type="nucleotide sequence ID" value="XM_038204903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060832.1">
        <property type="nucleotide sequence ID" value="XM_038204904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABK0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204902.1">
        <property type="protein sequence ID" value="XP_038060830.1"/>
        <property type="gene ID" value="LOC119731691"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204903.1">
        <property type="protein sequence ID" value="XP_038060831.1"/>
        <property type="gene ID" value="LOC119731691"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204904.1">
        <property type="protein sequence ID" value="XP_038060832.1"/>
        <property type="gene ID" value="LOC119731691"/>
    </dbReference>
    <dbReference type="GeneID" id="119731691"/>
    <dbReference type="OMA" id="IVLCTQR"/>
    <dbReference type="OrthoDB" id="6417325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29444" checksum="E1AF615359DFEA90" modified="2023-02-22" version="1">MASIGGGMQRWAGRVALVTGASAGIGQSTARALVRHGMKVIGCARNIKTIEEDAKVLSGDTSVTGSLHAIKCDLTKEEEILAMFAEIKEKFGGVDVCVSNAGINHADSMTSPMGILNGETAKLRDMFEVNVLAVAICCREAVKQMEEKGATDGQLLVTNSLSGHRLTTKDTYFYAVTKHAVTALVEAIRRELREKKNHIRIAQISPGIVETEFRERMYPGDNRDKARKLYKTMEPLLADDITDSMLYVLGAPTHVQVHDILIRPTEQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABL1</accession>
    <name>A0A914ABL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038061237.1">
        <property type="nucleotide sequence ID" value="XM_038205309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205309.1">
        <property type="protein sequence ID" value="XP_038061237.1"/>
        <property type="gene ID" value="LOC119731969"/>
    </dbReference>
    <dbReference type="GeneID" id="119731969"/>
    <dbReference type="OMA" id="HANDACA"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="16">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="15">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="16">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="768" mass="85161" checksum="FECF5E6E23D74654" modified="2023-02-22" version="1">MDEQQLGSELRSLVAKTVQYKAALKSVKVDKPESGGTVAVRESQPIVVHFNYNIANSPIVGGNLQDSYINYSYDNNGAKGVAIPPDPQQHKVLTGTGLEQLKEQEDKEPKADGQDTGQISKKQDLELKEDGREIKDTTVKELAENVCKEEHTVQECIAAPYKQEKGDWSFIGMRVVRGPDWQQGDQDGGCGCVGTVVTVKDAESKSRIWVRWDSGILAEYHGGREGHKFDLRIFDNAQRGVKHPRVACDGCLENGVVGIRWKCLQCDDYDLCHSCYNECKHDLDHPFMRIDEPGVPGVKVPCRLGATRLKAFGIFPGAKVVRGPDWKWKDQDEQSVGTVTEVENVKGKDGDSPGSSYRSLVRVRWPAGNSYNYRCSFQGKMDLQYFKKASNGEFFIDHLPVLDATKCRPWFAIGDKVRLMDIDLDKLKDLQQKRCGWIEEMKNFRGRIGKVKMVDSEGDVRVKFGRSLYAYNFRCLQKKTAADYVTRGPYTAYVNLLIKSAVTGDTSKVKEIITDHPDAAKHPNEQGITALQVAAHLGHFDVVSALVEGNAPLELKDGDGDTALAFAVMGNKPDVVQYLLLVGSNPNTYDEHGVTPLHLAAGHANDACAQALISSQEQQFDVNSQDIDGDTPLFIAIGLPRDNNTMIDLLIEHTTDDGLRLTNNDDFNSLHFAAFHGKKHAVEKILQRSPSMINLVKNDCFTALHIAAINGYTEIVKTLLKQENCDISARTAKGQTARDLAFEESKQECIDLLDAVSGGKKREDIMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACM9</accession>
    <name>A0A914ACM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061680.1">
        <property type="nucleotide sequence ID" value="XM_038205752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205752.1">
        <property type="protein sequence ID" value="XP_038061680.1"/>
        <property type="gene ID" value="LOC119732289"/>
    </dbReference>
    <dbReference type="GeneID" id="119732289"/>
    <dbReference type="OMA" id="VTLHRNM"/>
    <dbReference type="OrthoDB" id="10159826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="326" mass="36384" checksum="816DEEF0F9A653E4" modified="2023-02-22" version="1">MAVRSEDVSLSRTSRYELEGRTTSFACIVTRDDMGEDSKYHIIWSLGTSEISNSTSDLLHVTLHRNMSGAVLVCQVFSPSFNFKKATWTLDVMYPPNGVTLDVNSTHSCESDSMCSADVTVGRYYRFTCNASGSNPASNITWLINTKGRWGTTQREIPADRSRCRQAETDTDWDTSSHINLQILLEDRHGSVACRVMFLDASTVFREIVMTLQVVEPVEEPRNRPKVPLPENPELAKWVMVACIPTAAIITACVIGMVIARKLKHQSAPRQPRPQADATPPSSPKEGESHVSEDEGLYQELPVIHDQQTERSSPDQNTPLYHTTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF05</accession>
    <name>A0A914AF05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062298.1">
        <property type="nucleotide sequence ID" value="XM_038206370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206370.1">
        <property type="protein sequence ID" value="XP_038062298.1"/>
        <property type="gene ID" value="LOC119732721"/>
    </dbReference>
    <dbReference type="GeneID" id="119732721"/>
    <dbReference type="OMA" id="MQIRFLR"/>
    <dbReference type="OrthoDB" id="10443852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816350" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37222" checksum="6C927F73E0085668" modified="2023-02-22" version="1">MERILNLRTLLMILQAWAIVGFVSFDSADSLTSMMTPREQKVPEGEIFELKCVSRRVLTNGSRVRNELYKVEGDSRSYLSPSEANAGETNYTMPGPDRATVTTIFRLQAKENSAGRYGCVPILENATRPATFTSNQKRREVTVQVCSEPELEVEDIESDGELIYVGAESCGYNGELTWRVNGRQAPRRSTPDDERFPVVEREDSSLKIRSARCHDETIHNTCEVTAVFTYISAEKRVTSASKTKQIPDCCVQDVFLPTTEIETNADTTTKASSPAIFPTRSVDVDEKEVLALEKQVLKLKLEALPMQIRFLRRLNRDHSQGRDMEKVEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF41</accession>
    <name>A0A914AF41_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062362.1">
        <property type="nucleotide sequence ID" value="XM_038206434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206434.1">
        <property type="protein sequence ID" value="XP_038062362.1"/>
        <property type="gene ID" value="LOC119732830"/>
    </dbReference>
    <dbReference type="GeneID" id="119732830"/>
    <dbReference type="OMA" id="KIACNAD"/>
    <dbReference type="OrthoDB" id="10032694at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="55819" checksum="23437C3F4F78F860" modified="2023-02-22" version="1">MIPSERAIRKQQKQLLKDNLIGQKIKLLFNSDKADGMNGYEIREVPFVFVKDVPAMILDYLDRFERQGTLTWHNGIIPKDEVWIKIGGDKGGDSFKMDFQVVNVAHPNSLQNTVVFSCFEATDSMANIERALPPILEQISGLTSAKWCERSIRVFCFGDYELLNKMYGLCGCNARYCCIYCLASKTDMQQPLHERGKCQPRTLKSIREHHQLFLQDGARRPRAKDISFSVVNRPLIPVEIDHVVLPTLHISLGVFKKLYDLFERDCHDLDLELFHLRVKAQDNSDLTNFDDQVANEIERLRRIQEQLHDKRSALESAEEDLPLYVLQNEMEEIDDRFRDAASIAFKLRNDIQNLEKEAETSQLSYATGPVASSLDKVLHTFKVQRQAYHGKAFVGNHVHKCCEPKVIEALTKTPSKVIEKHLTDNMPLAALDRLRRKAATIQEKFEDIFLKFADVHKGINHTHAVTDSDIHCIGKCILQYIHTFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGA8</accession>
    <name>A0A914AGA8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062551.1">
        <property type="nucleotide sequence ID" value="XM_038206623.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206623.1">
        <property type="protein sequence ID" value="XP_038062551.1"/>
        <property type="gene ID" value="LOC119733039"/>
    </dbReference>
    <dbReference type="GeneID" id="119733039"/>
    <dbReference type="OrthoDB" id="6153184at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7121"/>
            <end position="7143"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="6799"/>
            <end position="6890"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="7032"/>
            <end position="7077"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="7079"/>
            <end position="7113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3420"/>
            <end position="3440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3793"/>
            <end position="3812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6435"/>
            <end position="6456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6738"/>
            <end position="6760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7176"/>
            <end position="7233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="6738"/>
            <end position="6747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="7180"/>
            <end position="7195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7196"/>
            <end position="7208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7214"/>
            <end position="7226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="7067"/>
            <end position="7076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="7341" mass="811012" checksum="F75CF8E0F7D955F5" modified="2023-02-22" version="1">[encoded data, 7341 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGP7</accession>
    <name>A0A914AGP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062887.1">
        <property type="nucleotide sequence ID" value="XM_038206959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206959.1">
        <property type="protein sequence ID" value="XP_038062887.1"/>
        <property type="gene ID" value="LOC119733373"/>
    </dbReference>
    <dbReference type="GeneID" id="119733373"/>
    <dbReference type="OMA" id="GIVECEC"/>
    <dbReference type="OrthoDB" id="5918941at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="552" mass="62890" checksum="F3143154C2E00176" modified="2023-02-22" version="1">MTDDTMEAAAPCTSRPHLSSYAEKLQIEDPLAYGRYIRKITDIGEDPFIHINKGSKTSGYSTHWRDLPEVTYRDIIFYLVETHSFYTIQQMRAYKGTDAYRFVYSGWVTTVRSKKCDDSKIIVTGKVRHSQQPSKTPCYSWVCTTADGIVLYGHCTCKAGLGEVCSHIAALLFYIDETVFHNTNATTNQECCTSRLCQWIVPKQLDKLELKMVKDMDFSNPKSRHSQLKERCATPRKEVKQPTEEEQSQFFRSIAACNQTSKVKCKPAILSLQDEFAEEYMPKTDSLPQNLLQLRQSDKLQTSLVSLQDEAAEIMTTLRVTPAQATNLQCSTCEQTQSKLWHTHRAGRVTASNMHAATHTSVDKPSTSLVKRICYPHTLQFSSDATDWGKNKEKEARNMYKEHLKSEHIHVNVSDCGLFIHPDFPHLGATPDGIVECECCGIGVCEVKCPYTCKNNTISSGVVKCLQRAESGDLCIDKRHPYYYQIQCQIFLTEAKYCDFIVWTNKDLHIERVYPDIPFWNDVVVKATSLFKKVLLPELIGAYWTRSAHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHF2</accession>
    <name>A0A914AHF2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063113.1">
        <property type="nucleotide sequence ID" value="XM_038207185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHF2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207185.1">
        <property type="protein sequence ID" value="XP_038063113.1"/>
        <property type="gene ID" value="LOC119733783"/>
    </dbReference>
    <dbReference type="GeneID" id="119733783"/>
    <dbReference type="CTD" id="25809"/>
    <dbReference type="OMA" id="DWNFYWS"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="423" mass="48980" checksum="4B76ADF3F4F2A27D" modified="2023-02-22" version="1">MSGRVVKFATDQDKTVLMGNFEKRGWVQVSPEEDWNFYWSNVQTTRNIFNVDTGYRLQDDQVINHFPNHYELTRKDLMVKNIKRYRKELDKEGSPLAEKDENGKYIHLDFIPVTFLLPADYNLFVEEFRKNPSSTWIMKPTGKARGIGIFLINKLSQLKKWSRDSRTSSFQAPSAKDAYVISKYIDNPLLIGGKKFDLRIYVLVTSYRPLKSYIYKLGFCRFCTVKYSANVNELDNMFIHLTNVSIQKHGEEYNSQHGGKWTVHNLRVYLEGTRGKEVTDKLFDEMNWVIVHSLKAMANVMANDRHCFECYGYDIIIDDNLKPWLIEVNASPSLTSTTANDRIMKYNLINDSLNIVVPNGEPPDVRWNKIPSKESYGNYELLYDEELAQLDSMERDSKSRLAGGMGFGARGRDAKTKGQATWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIN6</accession>
    <name>A0A914AIN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063845.1">
        <property type="nucleotide sequence ID" value="XM_038207917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207917.1">
        <property type="protein sequence ID" value="XP_038063845.1"/>
        <property type="gene ID" value="LOC119734418"/>
    </dbReference>
    <dbReference type="GeneID" id="119734418"/>
    <dbReference type="CTD" id="54680"/>
    <dbReference type="OMA" id="YWRVEWL"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="333" mass="38384" checksum="5462A2778CB3C931" modified="2023-02-22" version="1">MLLEQPRCKMSCEVCEQVQPKYKCPGCNVKTCSLHCVKKHKTARGCNGVRDKTTYVSIKGFTDQHLLSDYRFLEDVDRKAYSAITDDIAKQTQYKPKYYQLRKFCQTRKTFLKLLPPSFSRHKENTSWVSKREKVINWRVHWKFPQSDAEYIDKSVCEDRTLCDILATHLDPGKGDPVQRQRLKKYCRPGVNNLRLFMKEEGRPVNSLRYHRLNLGTTLRHNLSCKTIIEFPVIFVVLKEFADSYEMPVQVQSTSLVAQQESCPQPSSECIPEQATEDTPAHCSNERDAAIDTSVELHNGKVTEMTPDPGTEHSEDSKPPTEREPVPLEQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK73</accession>
    <name>A0A914AK73_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064018.1">
        <property type="nucleotide sequence ID" value="XM_038208090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK73"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208090.1">
        <property type="protein sequence ID" value="XP_038064018.1"/>
        <property type="gene ID" value="LOC119734555"/>
    </dbReference>
    <dbReference type="GeneID" id="119734555"/>
    <dbReference type="OMA" id="SWSTEAC"/>
    <dbReference type="OrthoDB" id="10065076at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="35794" checksum="5E8248BF5D7AA728" modified="2023-02-22" version="1">MMATEMAVGFGHQGMTAVNFGHNFPLHQHHQIDGYDYYTHQPARSYQDHVMVAQHNQHHDEVDEEDIEDEDIDEEEEEESENESMYTSADMDSEVASEDLAEPEPNVAEQLLEFAQAVNRDIQKYFGRKKSAHEPDSSVGTVYEDRFASGKSGRELYYADLLRVAQNGDAAEPYSTGRGRRTDASISPRASTSSASSAAENADVINANYSCQKGLGPLKELFDFAIGGCMDSISNDRRDGHWQSQDSSSSQKCFPTLPWRKRALPSSFFVEPGSRGQPRNGSVGYGSHVTMIPEHETPDFSDLVANFTSDYDNQLTATTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKM7</accession>
    <name>A0A914AKM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064550.1">
        <property type="nucleotide sequence ID" value="XM_038208622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208622.1">
        <property type="protein sequence ID" value="XP_038064550.1"/>
        <property type="gene ID" value="LOC119734963"/>
    </dbReference>
    <dbReference type="GeneID" id="119734963"/>
    <dbReference type="CTD" id="5170"/>
    <dbReference type="OMA" id="QYRVPDN"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000126">
        <property type="entry name" value="3-phosphoinositide dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="187"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="641" mass="72693" checksum="EFB1EE9531F9B21E" modified="2023-02-22" version="1">MSSADSLRRTAEPTGALLSPGAQLVPASCLCGHSELGPVNNKGLSGRGNDNKKSRLAVLRFARMLAVAFRRWTSKTKKSKEQARQPMRSSESQSRDKTATNGRSQAQCIKPQASRTVSAGTSCQRGSPSPSSSPSSAPTSSSLPSTSSEYLQNRPSASAGTSALAKKDMNQSPQPAAAPKKKQRQDFKFGKILGEGSYSEVVLATEIATGNKYAIKVLVKRHIFREKKEKYVMREREVLSKLDHPFFVKLYFTFQDKDKLYFGLSLAQRGELLPYIQKLGSFDENATRFYAAEVVLALEYLHNMGIIHRDLKPENILLNEDMHIQITDFGTVKILDANAKEVRANSFVGTAQYVSPELLTEKSAMKSSDLWALGCLIYQLLAGLPPFRASNEYMIFQKIIKLDYDFPEGFPEKAKDLVSRLLVLDPVKRIGCEDCGGFAELKAHPFFEGINWANLPNETPPTLKPCMVVDGEEIHSDFYIDEFDMSPLSEFLGQIKTNEENNRQKDTNQYKAKYVLPYTREEKAALLEKQKRECKWHRFVEGNLILKMASIDKRRGLFARRRQFLLTEGPHLYYVDPENMVLKGEIPWSHHLRVEVKNFKTYFVHTPNRLYYLIDPEGHALEWCRAIEEVYRHTYQNEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL61</accession>
    <name>A0A914AL61_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038064306.1">
        <property type="nucleotide sequence ID" value="XM_038208378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208378.1">
        <property type="protein sequence ID" value="XP_038064306.1"/>
        <property type="gene ID" value="LOC119734809"/>
    </dbReference>
    <dbReference type="GeneID" id="119734809"/>
    <dbReference type="OMA" id="TICYTEA"/>
    <dbReference type="OrthoDB" id="5859976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="35863" checksum="C7E8FC9B1243FB60" modified="2023-02-22" version="1">MYAVFQALFSVVGSLGFIGNVLVCVTICYTEALHSITNLFILNLAVADALASVAHVADPFTTQQLSVEKSLYNDTVTCPVQLNFWVSVQSVVYYLHSSLLAHSVFGLTLVTHERFIGIVKPLQHASYFSRRKIAVMLLAMWMTPLVVELPRFVYVIDYQRQKCTGDSEYEYMFSILSMLLLAGPTGAMVWMYVQILKNLKQGAKNLQQLGVKGSAKELLEAHKKVTVAMALVTAAFFILVLPTKIVKLTFEIIVKPSPLAVSQTFTLLVVLNSAINPVLYGFKYKQLRESFVSMVVGKCRKLKRQNHVQQAPRVEMVQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALA7</accession>
    <name>A0A914ALA7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-microseminoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064527.1">
        <property type="nucleotide sequence ID" value="XM_038208599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208599.1">
        <property type="protein sequence ID" value="XP_038064527.1"/>
        <property type="gene ID" value="LOC119734952"/>
    </dbReference>
    <dbReference type="GeneID" id="119734952"/>
    <dbReference type="OMA" id="CICIEYK"/>
    <dbReference type="OrthoDB" id="6076852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008735">
        <property type="entry name" value="PSP94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05825">
        <property type="entry name" value="PSP94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037617295" evidence="5">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="112" mass="11997" checksum="E4D0D42978C8EF40" modified="2023-02-22" version="1">MAAFTLVFALSLLFMAGVANTCEVVDGVECSVVGATVKDGLPKSVSGNCFTCICIKYNRATAVQCCSNALMPTGYDESKCELILNEKTCMYAVHEVESPHNGCPFTGYFFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMM5</accession>
    <name>A0A914AMM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038064684.1">
        <property type="nucleotide sequence ID" value="XM_038208756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208756.1">
        <property type="protein sequence ID" value="XP_038064684.1"/>
        <property type="gene ID" value="LOC119735064"/>
    </dbReference>
    <dbReference type="GeneID" id="119735064"/>
    <dbReference type="OMA" id="CFEKQSD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="51265" checksum="764244F4207CE78A" modified="2023-02-22" version="1">MFYTQKIHIDFHSDCICYCSPDFGANIKMMKVAVIGGGAAGLCAARYLCAKPKLYQATVYEQSEQIGGTWVYRDDVGKDKYGQPIHSSMYSRLRTNLPKEVMLFPDLPIAEGGKTSFIKHTEVLQYLNRYVDTFHLQKCIQLLTRVESVKPVTKCGKTAWEVTVQSVVNPDSPPTVNQFDAVMVCNGQYAVPNWPSIPGLETFTGKVMHSHDYRHPEHFRGQSVVLLGAGNSGIDISLDLHAYAERVYLSHLHPLLQASLPANLQQVPGIKSVREGRVEFTDGRSVAADALILCTGYLYDFPFLTPECEVSVDRKRVTPLYKHVIHTKFPSLSFIGLVWRICPFLLMSCQVRFVMAALEGTMILPSKEEMDADTQRDYDYRCKELNMPHHYAHKLGDMQWEYCKELVRLANDVDAEDATKPIFEELYLDCSYWRSQDPLNYKTRTYELPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANS2</accession>
    <name>A0A914ANS2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L17, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065675.1">
        <property type="nucleotide sequence ID" value="XM_038209747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209747.1">
        <property type="protein sequence ID" value="XP_038065675.1"/>
        <property type="gene ID" value="LOC119735806"/>
    </dbReference>
    <dbReference type="GeneID" id="119735806"/>
    <dbReference type="OMA" id="MAFLEYC"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L17, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="29168" checksum="EE86EC43A39223DD" modified="2023-02-22" version="1">MPNAGSPSIFNVSAKSQCKRTLANLGFEIITFWEKTLWKIEILRKYFVSYQQGTMRYGKVYRRMAGGPQQRLNLLRHFITALVKYERFEAPYAKAHETQKYAERLINIAKRGDTDEEAMKIADYWLSDKKQIHKLFKVLAPRFRDQQKNYTQLLRVPGFSGEGNVAMAFLEFHGNPYPPLRPVKKKNPDWIVNVLLREAVQELKASRVLAEGRSRPEEGVMTQLGEALDNLRLGESPEGAVADGPGADPQKDGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APZ5</accession>
    <name>A0A914APZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Selenoprotein S</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the selenoprotein S family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066110.1">
        <property type="nucleotide sequence ID" value="XM_038210182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210182.1">
        <property type="protein sequence ID" value="XP_038066110.1"/>
        <property type="gene ID" value="LOC119736160"/>
    </dbReference>
    <dbReference type="GeneID" id="119736160"/>
    <dbReference type="CTD" id="55829"/>
    <dbReference type="OMA" id="KIAMWEN"/>
    <dbReference type="OrthoDB" id="75792at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036513">
        <property type="term" value="C:Derlin-1 retrotranslocation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036502">
        <property type="term" value="C:Derlin-1-VIMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009703">
        <property type="entry name" value="Selenoprotein_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28621">
        <property type="entry name" value="SELENOPROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28621:SF1">
        <property type="entry name" value="SELENOPROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06936">
        <property type="entry name" value="Selenoprotein_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21374" checksum="7753C6FE7CC7B12E" modified="2023-02-22" version="1">MSEGLFEDRKLPEDGNQTPESVTQGVGYASEFLSSYGWYIILGILGFLYLYGRFGSRLEQWKQKREENTNLSQYDAGDVLARQEAMEKARQRMQQEYDAIAAEHAEKQKEREEEKRKEQVEDWERHKRGQGYRSKKLNKEDGQQQASGTASGSKEKPKKPPLRQGYNPLMGGTGSGFRPARSSRSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASE6</accession>
    <name>A0A914ASE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066379.1">
        <property type="nucleotide sequence ID" value="XM_038210451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210451.1">
        <property type="protein sequence ID" value="XP_038066379.1"/>
        <property type="gene ID" value="LOC119736429"/>
    </dbReference>
    <dbReference type="GeneID" id="119736429"/>
    <dbReference type="OMA" id="KIMTQHY"/>
    <dbReference type="OrthoDB" id="10035043at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="476" mass="52599" checksum="EC6B5A6888D199A5" modified="2023-02-22" version="1">MPIKLSTNCLRSLNERHSLAMAVPSPRASVLVAALVAAVWSHASHAAEENPVVVAPAAAAAATGEVGWTDFWLVRLSLNILGYGSVCLPAWLFIRYVKRSGYLEQGGENGHNCMFRSIRLCVAGNEEKTSLEEGGVKATAPEPPKFNKGVVLFFCVLGLQGSYLTWGVLQERIMKHEYGKDENNPGEKFTNSQFLVFMNRILAFSAAGVIILVTRQPRHTAPLYRYSYCSLSNIMSSWCQYEALKFVSFPTQVLAKASKIIPVMLMGKVVSGKTYEYYEYLTAAMISMGVAMFLLTQGKEATGPTTVTTFSGVLILIGYMMFDSFTSNWQAELYKQYNMSSMQMMFGVNLFSCIFTSWSLIGQGGFAVGLGFMLKHSTFMFHVLLLSLCSATGQLFIFYTISQFGAVVFIIIMTTRSGLAIFLSCLIYGHPLTVIGVFGVFIVFAALFLRVYAQQRKKAQKAREARQSELSNGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATJ5</accession>
    <name>A0A914ATJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067370.1">
        <property type="nucleotide sequence ID" value="XM_038211442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211442.1">
        <property type="protein sequence ID" value="XP_038067370.1"/>
        <property type="gene ID" value="LOC119737244"/>
    </dbReference>
    <dbReference type="GeneID" id="119737244"/>
    <dbReference type="OMA" id="DSANCME"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000018">
        <property type="entry name" value="DNA cross-link repair 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="768"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="866" mass="95608" checksum="5F36719FA66C9502" modified="2023-02-22" version="1">MSTFGGLMVEYPQIAIDRFLGPAVLRARAYFLSHSHADHMVGLDSSKFSQRLHLSKRIRLYCSEVTREFLLTDRRYVHLESSITSLPIEEPTTVALYNEINGEEEQVLVTLLAAGHCPGSVMFLFEGEAGNVLYTGDFRLAKGEAARMLPLHSGNRIKDIKSAYVDTTFCVPEAMYIPSREQSRDALLDLVEKQIQQSPTHMVRLACKAKYGYEYLFVEISKEFNLKVHVSPVVMAQYERVPDLAKHLTSDGRSTQVHACRYVDCSMQHATNVLVVVPSTMWFTSNARPSDVLKKVGHRYRLCFSFHSSFSEVRDFVGYIRPVNIYANVIPYNCTEEIINERLQDLRRAADKPQSVNQPSVYKPLGQLKKSVRASWRKTAVPHTNDENDDELAEMFNSSPPPVKKRKERSPQGKELCDGQAWENVHVSSESGDFLEGSTQESYLAMDDSDLSSGELDLYDSAPDQSQPVEDSQEGSKDLDNGLGEFVKSLRDYTPHNLRSDPVGSLQGAGLSEGGSEKQLQRESKRAEIDSWLRFLPDADTDKESKEGGGSETATPPPSGQQHSLTETEPADTHPRGDAGPPDSANCMETKHGSITELGSSQDESDKTDEYSIKNSQETPAPDGELMRRTKQSISVQLDGSRCKADQSDDRTSEACDKEDKMETITLVDLTDAQQKHGSGTLLDLVDNGAMELQKEVAQVCSDDCKTLKPDSVGLRSQESQVKPVVCSSRETMGQDSANTERHKNTNISHTAVYGTVIESKSHGTVVLSSQNSSAGSVVPLGTDDTLGTDDEAHLELSQGTSQSQDTFLPSSQGSVVSRSSSDFDVPCTPEGKGLRPERLEAVWVMIAKGESMPVMSCNKTIQLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATX9</accession>
    <name>A0A914ATX9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067128.1">
        <property type="nucleotide sequence ID" value="XM_038211200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATX9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211200.1">
        <property type="protein sequence ID" value="XP_038067128.1"/>
        <property type="gene ID" value="LOC119737104"/>
    </dbReference>
    <dbReference type="GeneID" id="119737104"/>
    <dbReference type="OMA" id="HILMNRM"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="5">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="216" mass="23211" checksum="5742C9F04086EB06" modified="2023-02-22" version="1">MIRLVSGDDKWSGQVEIYRHDAWGAVCDSSWDMKDATTVCHQLGFIEALEAKTGLSSRESDRPIVMNRVACTGTERRLADCPFVCTGSQQCSSSTVAGVVCKPRPDELRLVGGSRTSGRVEIYRGGSWGTICDSNWNETDAGIVCRQLGFSDALEAKSAAHFGQGSGPVHMDGVACEGSEEKITDCPSYCWEETSCSHSHDAGVICSDGNTVTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW09</accession>
    <name>A0A914AW09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067942.1">
        <property type="nucleotide sequence ID" value="XM_038212014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212014.1">
        <property type="protein sequence ID" value="XP_038067942.1"/>
        <property type="gene ID" value="LOC119737564"/>
    </dbReference>
    <dbReference type="GeneID" id="119737564"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18067">
        <property type="entry name" value="DEXHc_RAD54A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000169">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000147">
        <property type="entry name" value="RAD54 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="183"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="513"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85045" checksum="27341F1C0D64E139" modified="2023-02-22" version="1">MLRSLAPSRLAQTDRHNGKRKSAAEHAQGDDTAYNKTGPRKKSKLSDGASQKPSPGPGFTSIMRRPLNMLNNAGASPARSSHEDMIRSILSRPFKVPIPNYKGPTLASRGLGIRRQGLRQPLHDPFEEGALVLYAPEQVSAQEQLTIDREKMEVHVVVDPLLSKVLRPHQREGVKFLWDCVTGRRIDDSFGCIMADEMGLGKTLQCITLIWTLLKQSPDAKPELDKVVIVAPSSLVKNWHNEISKWLGSKLNALAIDSGSKKEIDANLESFLTQKGRRILNPILIISYETFRLHAETLHRGSVGLVICDEGHRLKNSENQTYQALNAMNAKRRVLLSGTPIQNDLLEYFSLVHFVNRGILGTASEFKRKFELPILRGRDASCTDKDKQKGQEKLLELAALVNKCIIRRTSALLTKYLPVKIEQVVCCNLTPLQNALYKQYVDSKMRECTAASKGKPAASSLSAITQLKKLCNHPALVYDKCRDGDGGFEDSLQLFPDNYRPGKLQPDLSGKMLVLDYLLAVTRTTTSDKVVLVSNYTQTLDLFEQLCRLRGYIFVRLDGSMSIKKRAKIVDKFNSPTSPEFIFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDDQAMARVWRDGQKKECFIYRLLATGTIEEKIFQRQAHKKALSSCVVDNEEDVERHFSLDQLRDLFPLNESTISDTHDKIKCRRCVNSIQARPPPAGTDCNSDLAHWNHCASKRGIPDVVLKQALETNRVTFVFHHRSHEQIKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW19</accession>
    <name>A0A914AW19_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067451.1">
        <property type="nucleotide sequence ID" value="XM_038211523.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211523.1">
        <property type="protein sequence ID" value="XP_038067451.1"/>
        <property type="gene ID" value="LOC119737295"/>
    </dbReference>
    <dbReference type="GeneID" id="119737295"/>
    <dbReference type="OMA" id="HCQALWH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004162">
        <property type="entry name" value="ATP binding cassette subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006082">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="311"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="695"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1567" mass="176313" checksum="6D1FB746F3C625A4" modified="2023-02-22" version="1">MDTTEASPFDWYCGANATENLASFTFDLNHTLYNACFVDLVYTLPHLIFILLGILVLFVLRCCTSIRKEQHPYLVQFPGHNIRWVLNFVLLSLTVCELGEGILTDIDVYLDTPTIPRLYVPALLSLTAALLTMIYYNQMELWSRPHMSWVLLAYWLTALGVEIIRFLNLNHDEDVNYLILRYDLTIAAIVMYFLYLMLEVWVIISKICKCCCEEEEFPEDLKKEDMYYLQGYTSLLSSAFYWWLNWIFKKGFKQALELTDLGSLSEVHTTQYQRDAFTRALKKEQVRAKAHRKPLSLFRVYVRAFGFRMMIGGFVKICGDISTFIPPLALASAINYVTDVYYGRELQDYGDTKYISAGDFLRNGFILVVVMFWATIIKVICQQGHYHVVITESGHIKAALQAAIYDKSLRLSSYTMSGGYMTMGQITNHMSVDTTNILNSAQWFHYIWSIPFVIAGYMVILYSQLGSAALIGCLVFFVTIPIQVFIARQTAKYQKTTMLKSDERLKRTNEMLQGIKLIKLYGWEDMFYTSISKVRALEILAMVKQMVFKVVLMTISNACPILVTIVSYSLYTKLTGEPLTPDIAFAALSVFNQMLTPLFIMPNVFVYHINAIISTGRLRMFFEAPEIERQEGEEFWAGGRDKNGALQSGRRSSKPEDKQRLLSNDNQADHDNEYGTFDAKTTSFIVPSVPDDIAVRVKGSFTWDSSAKSPTLENISLDIPTGKLTMVVGQVGSGKSSLLSAILGEMTTVSGRVQWNRKYNSVSYGAQKAWLLNASLKENILFGNKFDHERYRKVITACSLQPDIDILPAGDQTEIGEKGINLSGGQKQRVSVARAMYSRNDVVVLDDPLSALDTHVGGHLFKKGIEGFLMKKSKRTVILVTHQIQYADKADKIVYMKDGHILHQGTVEDIQEENRELVASWRATMKMLAESESELSGSETGVDVTEERAKLVRQVSKQLQEAKRMEEEVQASTSGRLVQKEERAEGSVSWRVYLSYVQALGYWVFGLILLLSVLQSGLSIGTNFWLSEWSEAGANMTNATESELLDSLTYYLGGYAGLSVSSIVAGAGATAMLYIGSLYAARMLHNGMLRTVMHAPLRFFDVTPIGRILNRFSSDANVIDQKLGVTLSSLLRNGLSCVSAVLVNIIVVWFFAIALIPIIILYLLMMKVFIRTSRELQRLDSINKSPVYAHFSESLGGLSTIRAYRQQHRFQDLIIKKIECSNITFLYLNTSNRWLGSKLDLIGALIVLIAGLTTMITALTTHTLTPSLVGLAITYALNISTQLNWVIRMSADMEMQMNAMERVEYYKSIEMEEYRGTQSPGPDWPDRGDIVYDNISARYATHLDPVLYNVSIHFKAGEKIGICGRTGSGKSSLTLTLFRIIQTFTGSITIDGVNIAHLPLVEVRRRLAIIPQDPVLFTGTIRFNLDAQNAHDDNALWEALETAQLKDVVSELDLGLDAMVTEGGENFSVGQRQLFCLARAFLRKTRILVMDEATASIDLETDAILQEVVATAFRDRTVITIAHRVQTILDSDHILVLNEGRIAEYDTPENLLAWEDSIFASLVRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY28</accession>
    <name>A0A914AY28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068424.1">
        <property type="nucleotide sequence ID" value="XM_038212496.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068425.1">
        <property type="nucleotide sequence ID" value="XM_038212497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212496.1">
        <property type="protein sequence ID" value="XP_038068424.1"/>
        <property type="gene ID" value="LOC119737866"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212497.1">
        <property type="protein sequence ID" value="XP_038068425.1"/>
        <property type="gene ID" value="LOC119737866"/>
    </dbReference>
    <dbReference type="GeneID" id="119737866"/>
    <dbReference type="OMA" id="XENADEC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50574" checksum="045C0F39B14EDA02" modified="2023-02-22" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYVGDSKLQLERISVYYNQATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVSELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGIMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADDDDGDYEDEEEEEEDENEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYC7</accession>
    <name>A0A914AYC7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein BRI3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain protein I3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with BRI3BP. Interacts with MGAT1 and IFITM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069150.1">
        <property type="nucleotide sequence ID" value="XM_038213222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069151.1">
        <property type="nucleotide sequence ID" value="XM_038213223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213222.1">
        <property type="protein sequence ID" value="XP_038069150.1"/>
        <property type="gene ID" value="LOC119738358"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213223.1">
        <property type="protein sequence ID" value="XP_038069151.1"/>
        <property type="gene ID" value="LOC119738358"/>
    </dbReference>
    <dbReference type="GeneID" id="119738358"/>
    <dbReference type="OMA" id="PQHNYPN"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="123" mass="12823" checksum="90A129EB3F615A21" modified="2023-02-22" version="1">MSDPFKGEQPPAYTPAPQGYGAQPAPQAYPGVQGYQGYQTGAPPGYQQVTGAPPAGYIPAQPIRVTSTNVVVVGGCPACRIGILEDDFTLLGVCCAILFFPLGILCCLAMRQRRCPNCGAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1M2</accession>
    <name>A0A914B1M2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069694.1">
        <property type="nucleotide sequence ID" value="XM_038213766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1M2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213766.1">
        <property type="protein sequence ID" value="XP_038069694.1"/>
        <property type="gene ID" value="LOC119738806"/>
    </dbReference>
    <dbReference type="GeneID" id="119738806"/>
    <dbReference type="OMA" id="PRHKYID"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="60260" checksum="A05C6DF1E2595CAF" modified="2023-02-22" version="1">MAIADKVISVLTNAIYISTVPFLLCAVVTFLVTTLIWRRLTYWSKYTWPPGPRGWPLVGNSLLIAPNSGQTNANITRIGKQYHPDMFTLTLYLGKKVLILNSYKAIKDGLIRQSELISNRPPDWPFKYINKNRKSVGIFFESYTNSWKREKKYMMRTVRHFGYGTSAAQPLIHREANHLVELIKKRNGQPCFLGNPVSLCFLNVTFSMIFSATYEEDDREFSKILNIIRNWFTPIFNMYDVEPLLPFLHRFGLGSRLKQGKRNTEDLLGFIKNHIDRHRVTLDPDNPRDMLDECLIEMAKGDPNSDLSRGFKEENLQWMLVFFILDQGDTTTGLFLFLILATAFHAEVQQRVFQEIQDVIGDRPPSQNDKEKMPYTEAVILETLRMDTNFWLWIAHFTAADVDVLGYKIPKDTSVIPNIYSVHFDPELWGDPEDFRPERFIDEQGRISKPEYLIPFSIGRRRCIGEQLAMKEFFLFYITLLQNFKFKLSESDPKPKLEAKFLEVFPEDYRVVAEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1R6</accession>
    <name>A0A914B1R6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sorting nexin-16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Homooligomer. Interacts with EGFR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069942.1">
        <property type="nucleotide sequence ID" value="XM_038214014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1R6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214014.1">
        <property type="protein sequence ID" value="XP_038069942.1"/>
        <property type="gene ID" value="LOC119739183"/>
    </dbReference>
    <dbReference type="GeneID" id="119739183"/>
    <dbReference type="OMA" id="CTRMEDK"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000011">
        <property type="entry name" value="Putative sorting nexin-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="17">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="399" mass="43639" checksum="63D8D2BED90ACE64" modified="2023-02-22" version="1">MPSPRKACERMEREIDHQRIDGTSAMTDVAVDASSETRPQKTAAALAALSMSMPSSVNDPDVQSLPREIVDGQPEASTLMTSTPNSSSAAQRPRNLPGRLVAAPGTSGQHRSSGYSASSLGVGTCVNVAVEDPAGEEITLRAPIVGYEVMEQRAKFTVFKILVRKSEQDSWFLFRRYTDFVRVNAKLRHIFPIFRLALPPKRWFGSNFDPNFLEDRQLGLQAFIDNIIGHKDIVLSGPVREFLCLDDPPGPYDNLEESRALCESLDETVYNLRLELAERDRQIVSLSAELETAQEHISQLQNSSGGKSKTENVPNSSTPVSGESSTIEGDLHSQAEADQSMSFPQSEIQHSPETSLNKGSISANDTESKASPTPRKGTGHKQGGTRQDDQQTNNIISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B262</accession>
    <name>A0A914B262_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069879.1">
        <property type="nucleotide sequence ID" value="XM_038213951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B262"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213951.1">
        <property type="protein sequence ID" value="XP_038069879.1"/>
        <property type="gene ID" value="LOC119739122"/>
    </dbReference>
    <dbReference type="GeneID" id="119739122"/>
    <dbReference type="OMA" id="WKARKRF"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036742607" description="Bactericidal permeability-increasing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="9">
        <location>
            <begin position="273"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53355" checksum="ECFAD4A3331F0B59" modified="2023-02-22" version="1">MALTIALLLATCLMMGPSVEAEVRPGFEARISQSGLNYLRDAGLEILKEEIKHLSIPDISGKAHVSVVGNIYYTISNMRINSFAIPSATLTTQSGVGLVLRASGITLSLSGNWHYSNHGFIHISDSGTFDASLSGASLAVTLRIGKDQAGRPTVSSASSDCSFNAGSVHVKLHGGASWLYNLFSGSISNSIKSSLNKQTCSMIIKEVNTDLQKQFSKLKTQAPIDQYAVIDYSLVTAPQFSGHVDTAHKGEVFPRDTPHKEAPYTVPVIPPDPDVSRHVFLWVTDYLFQTAAYVYYEAGKFEFNVTQDKMPPGKYSLNTSSFLVESLLPNVSKKYPNLLMQVNANATAPPVINIGEDNVNVSLKADLDFFVTLPNKTLVYLFTLNSTISCSTLLSSDGMSLKWMTDSLRIVVALKRSAIGKIQMKPISEAVHALTSFFLIPWINEEGRKGFPLPTSPNIKLEKTVINWLYNLFSGSISNSIKSSLNKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B279</accession>
    <name>A0A914B279_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase TRIM71</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein lin-41 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase TRIM71</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 71</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038070018.1">
        <property type="nucleotide sequence ID" value="XM_038214090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B279"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214090.1">
        <property type="protein sequence ID" value="XP_038070018.1"/>
        <property type="gene ID" value="LOC119739235"/>
    </dbReference>
    <dbReference type="GeneID" id="119739235"/>
    <dbReference type="CTD" id="131405"/>
    <dbReference type="OMA" id="WKQFDSP"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19812">
        <property type="entry name" value="Bbox1_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19796">
        <property type="entry name" value="Bbox2_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000080">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF48">
        <property type="entry name" value="PROTEIN WECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="22">
        <location>
            <begin position="385"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="502"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="546"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="593"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="641"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="687"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="23">
        <location>
            <begin position="734"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="774" mass="86148" checksum="E003DDF4C9D52292" modified="2023-02-22" version="1">MAAFAPAAVAEDYNNEQQWCALCSERLQGTEPKILACLHRFCRPCLEMRVAEPDRIRCPICYQESQLGDLGVDGLPSDLFISNILDVVGSHEDDGDGVVSSSERRTCSSCDEGQVASRLCRDCNERLCESCVLAHQRVRLTKDHEIVTLQSSGPSTSGSYHRHAQRQSYQAQIQPVSDRPPSYCEIHQNEVLRLYCDSCSKAICRDCTMMEHRGHSCVYLQNAVEDSKAITLRLLSDAKNGMQALQESLSHTKGMAERVEMRTQLVVKEVQTTMHRHLTALEEREQDLLRKVDKIRQVKGRALHMQMEDLKRGLESVSNCVGAVEKALQSGTDLDVLKTKDMIVNQMQALRSLRGHLQPHEDDQVVFTPPDTALHTAISSLGFISSSAYAPTSYATGDGLKRALQGKITTFVVHAKDHNGECRCIGGEAVEVIIQGPEGGLYPAEVIDRQNGTYSISYRPQLEGRHVVSVTIRGTHIQDSPFIVTVRTGRNYTNISHVQLAFGTEGEGDGQLCRPWGIAVNKDNFIVIADRSNNRIQVFNPDGTFHHKFGSAGSRNGQFDRPAGIAIDNQGNIIVADKDNHRIQVFSFEGQFLFKFGEKGSKNGQFNYPWDVAINNEGKILVSDTRNHRIQLFHPDGTFCNKYGFEGALWKHFDSPRGVAFNNEGHVVVTDFNNHRLLVIHPEFKTARFLGSEGTNNGQFLRPQGVAIDQEGNIIVADSRNHRIQVFQPNGNFLCKFGIQGMQPGHLDRPSGICVTHDGLILVVDFGNNRVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5G1</accession>
    <name>A0A914B5G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071323.1">
        <property type="nucleotide sequence ID" value="XM_038215395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215395.1">
        <property type="protein sequence ID" value="XP_038071323.1"/>
        <property type="gene ID" value="LOC119740178"/>
    </dbReference>
    <dbReference type="GeneID" id="119740178"/>
    <dbReference type="OMA" id="TGIHWLW"/>
    <dbReference type="OrthoDB" id="6366227at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037034210" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="252" mass="27803" checksum="173742C93B0A83F3" modified="2023-02-22" version="1">MYIAAALSICSAVVLATWASETCHSEAGCCPRGWEPWGGSCYLIIKSGNWDDAWSACLAMGGVMAAPRSQEENNFVADKAHGMTGIHWLWVACTNTRGTWRCGGQDMGGFVNWRPGQPSGGVREQHCAALTSWAYDNYGKWHGVRCNNMYRRTAAACVRRPSQPRQFCLFTGRDGRPVESRCLHGHVVREYPLASATVGLCGRACYNDPRCFSFNIKKYHNGETICQLNNATSSDDPVKFQDSGSACTYFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7E5</accession>
    <name>A0A914B7E5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072106.1">
        <property type="nucleotide sequence ID" value="XM_038216178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7E5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216178.1">
        <property type="protein sequence ID" value="XP_038072106.1"/>
        <property type="gene ID" value="LOC119740767"/>
    </dbReference>
    <dbReference type="GeneID" id="119740767"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="37771" checksum="77439172A78D5879" modified="2023-02-22" version="1">MLEMENLSAVMKKKGELVLENTPIPLPGTEEVQIRVSAVGICGSDNHYLEHGGIGPFRVTSPVILGHEPAGVVCALGEGVTSLQVGDRVAIEPGVPCRMCSYCKEGRYNLCPDIVFCANKPTRGFMRRFSCHNADFCHKLPDHVSLEEGAILEPLSVAIHACRRAEICLGSRVLIMGAGAIGLLSMLTAKAMGATRLIVTDVVQDRLDFAKKLGAHHALRVDTRDAEEMARRVEAALGCKPEISIECSGAEPSIQTGTYATRSGGVLVLVGNGSTPTVNLPLVNAAVREVDIRCCFRYVNCYPLALEMVALGKVDAKPLITHHFPLEKTLDAFETSRTGAGGAIKVMIHCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B857</accession>
    <name>A0A914B857_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038072005.1">
        <property type="nucleotide sequence ID" value="XM_038216077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B857"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216077.1">
        <property type="protein sequence ID" value="XP_038072005.1"/>
        <property type="gene ID" value="LOC119740699"/>
    </dbReference>
    <dbReference type="GeneID" id="119740699"/>
    <dbReference type="OMA" id="SEYYYDT"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF2">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="449" mass="51280" checksum="6BD61638ADECBB42" modified="2023-02-22" version="1">MICKLFNCKSSGHGRFISNRVVRLVLALCLGMTVYTLVIGTFKFTTIQTIRERIPFLANKAFTIRPLTSGRNDTLHSTAPQMKEESGNLPNIDTLIQGIAFNQTYKDALAADIERREAQRPSNWRLSDAQYTSDTQFVNYMNCATSVRKKLLLESFFTKKYLPEVPILIWNKHYSQEEYERLAQFRSIFGWKVASASVISSALSLLNTTSNTYMFDHDRSPGQDGCTSCAVIGNGGILNGSKMGKEIDSHDYVFRVNVALTKGHEEDVGTKTSFYCAAFRSLSNSVMSGARYGFHAPPYQKGIRYVFFPKTDWAYMFLSAVFSDKPAPRNPADGRSPPKFQTKLTANDVKLVHPDFERYIRDRWVNSTRRKNVEFYRPSTGAIMLILALHTCDKVDVYGFAGSFTKYSEYYYDTAFRKHVSYLNHDSDIEKELWIQLHQLGIINLYTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8N4</accession>
    <name>A0A914B8N4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071782.1">
        <property type="nucleotide sequence ID" value="XM_038215854.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071783.1">
        <property type="nucleotide sequence ID" value="XM_038215855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215854.1">
        <property type="protein sequence ID" value="XP_038071782.1"/>
        <property type="gene ID" value="LOC119740515"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215855.1">
        <property type="protein sequence ID" value="XP_038071783.1"/>
        <property type="gene ID" value="LOC119740515"/>
    </dbReference>
    <dbReference type="GeneID" id="119740515"/>
    <dbReference type="OMA" id="ETHSMPR"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039737650" evidence="17">
        <location>
            <begin position="28"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="245"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="502" mass="57538" checksum="950E089CBD41AABC" modified="2023-02-22" version="1">MDAISFCAPLVVLLSIILSIFPQGCLASEAEERLFNTLFTGYNRLIRPVRNNTDTLKVEFGLTMSQLIDVDEKNQIMTTNVWLKQQWFDYKLSWNPEEYDGIMILRVPALMIWLPDIVLYNNADGKYEVTLMTKALVYSDGTIYWLPPAIYKSSCKIDVRYFPFDQQECIMKFGSWTYDGLLIDLMPLGGPDVDLEDYWQSGEWYIIGTPGTKHTVKYPCCDEIYTDITFNMIIRRKPLFYTVNLILPCVLISFLTVLVFYLPSDSGEKITLCISVLLALTVFLLLIAEIIPPTSLLIPLIGRYLLFTMVLVTLSIVITVIVLNIHYRAPSTHIMQPWVRRVFLEILPPLLYMKRPQRYPSKANKGTQRDPNYFELKEVVHKDADSTRSNGRDIYDNHHSGFKLRTLSDDVAGSDGESSKSSGGTRFSKEFKQAVDGVRFIATHLKTEEDYNRMTDDWKYVATVIDRIFLWVFLICVICGTSGIILSAPLIFEPVLEQDDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9T0</accession>
    <name>A0A914B9T0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072943.1">
        <property type="nucleotide sequence ID" value="XM_038217015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9T0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217015.1">
        <property type="protein sequence ID" value="XP_038072943.1"/>
        <property type="gene ID" value="LOC119741264"/>
    </dbReference>
    <dbReference type="GeneID" id="119741264"/>
    <dbReference type="OMA" id="VCDQSEP"/>
    <dbReference type="OrthoDB" id="10058592at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004333">
        <property type="entry name" value="SBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24401">
        <property type="entry name" value="SI:CH211-243P7.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24401:SF29">
        <property type="entry name" value="SI:CH211-243P7.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51141">
        <property type="entry name" value="ZF_SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP-type" evidence="2">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116827" checksum="85CB1587C7D132AD" modified="2023-02-22" version="1">MCTHPPRVDNYFAQKLLLWLPRRLWRVKLYCPQPLCINRELTSAGLYPHIRQVVDIDSRYNLATEYLECSHCRRKVISWSDDILKQLSVPQQTQFPVILTYKKACDVKVIRLLRQRGLGNSASQLQKKIHEQHSESWLMKTAHYLSDCKIFVDASNQGLISMPNLEEPVPFVALPQSRWFQTVYCKEVLQHLPEVKAAITSVFGNVLKMDSTKKIVKKLAGTGARTASWATNVGNEFGQVLISVMTASEGHAGLKPMVTGLVERYRSSGMTPPQLLYVDRDCCGSQSHLRTLFGGWPSLMIRLDVWHFMRRIATGCTTDAHQLYGVFMGRLSNCIFEWSASDVERLKVAKRGQLQGQHVSGLSDDDIIKRITRKELARHCRRRTRTVANIEKSIHELLVAFLGNQGKDTLGVPLLKADMMRKIWDTQKKHLACLQDPEGLQLYAQTGTIMKGGFQLPVYRCARGSTSLESFHLHLNRFIPGSTANDLNFQAYLLEGLVRWNEDRALAATDTPAGVRSYDGLLRQSVNELGQTVFGKNFGGSYTVPQKYTGELIGMEYLYRQTGEVLEDIAEQPNTDEDDTGEDDIGDDDDDEGFYADSFDDLTVPSPDSVAPHHTSPLQVRQQLALDSDVASTSAEPDIKAMPHGQKSSVPLAAVDMPAMDTTFQEIPLPSAPTSPPVESPESTCPPESHNPDESVGPDSIPGYGRVDQLAQTLFTLKDQSGPVTYVQAMEIVRLWRSLEVYDKKPTVFSPRFKAKITTGRFKVSKTTVQPGVESTKRCFLGESSGPAQWPDCNRYVESLMSKLCECFPSSTRSEGKHTPRWTHITRAYKNIRQKVLDSAIIMSETSLQLVDVNNTTLMQWYNKKMKKQEKAVLMQGITHKPAPHTAPDPLPEPVTGPRLMPQPKSNQPHVFVMPANTAGQANTRGYVAQPMMFQVLGQPAVSQPLQAEPSTRPASTLWYQKRKAEKEAAGQFSRKYVKKTDKIICSKCQQPREKETHKQYYGSWYCATTSDKTYDEWKEGLPSYQKKNRAQNPPTSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBF0</accession>
    <name>A0A914BBF0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073376.1">
        <property type="nucleotide sequence ID" value="XM_038217448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217448.1">
        <property type="protein sequence ID" value="XP_038073376.1"/>
        <property type="gene ID" value="LOC119741621"/>
    </dbReference>
    <dbReference type="GeneID" id="119741621"/>
    <dbReference type="OMA" id="ESWCAVE"/>
    <dbReference type="OrthoDB" id="5945439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="93" mass="10854" checksum="E8D6B55AF994E71D" modified="2023-02-22" version="1">MSKNSAQNGGSGEPNMHEINMQRESWCTVEMNSRQDWCRAERKHDKNAFKSSVFSEGQSQPDSDSRCTFEVNDKTHKERRHFPNKSYYSHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBM8</accession>
    <name>A0A914BBM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073632.1">
        <property type="nucleotide sequence ID" value="XM_038217704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073633.1">
        <property type="nucleotide sequence ID" value="XM_038217705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217704.1">
        <property type="protein sequence ID" value="XP_038073632.1"/>
        <property type="gene ID" value="LOC119741807"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217705.1">
        <property type="protein sequence ID" value="XP_038073633.1"/>
        <property type="gene ID" value="LOC119741807"/>
    </dbReference>
    <dbReference type="GeneID" id="119741807"/>
    <dbReference type="OMA" id="IMANKRF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="23"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="48601" checksum="8DE7F893AF1D4C49" modified="2023-02-22" version="1">MVSAGLQQPVTVNYDQDRWGWLMVAAAFVNAFVIMGQLKALGVLLIPMTNDFDSELWLVGWVAVLYSMTQDCFAPVVGALSRLLGARPMIVMGGVLYTLGLILASISPSVPLLAVFVIGLSGFGASFNWYIGFAVMASYFKEKYPLAIGLSTMGIPLGIMAYGPVTQVLLNTYGWRGTMLLLGGISFHLVACALLVRRDPSSNSANSDTDQYQEVLVLDEEENAQEEGDAPNHTRRTQEKREKTYCQRLIEAMDFKVLADKRFALLVCGGCSAAFAYSAWLVFMVPYGKFQGLNDTQASFLPTAFGIGNVIGKLLAPLLQELGMKLPMTFWACFGAALISGSFVVNAFIRPFIGLLAVTGLVGVGYAAMYQAIDVILRFISTDDRLVSILAWQGVFAGVAGALGGLVSGWIYEWTGTFFISFFVYAGVTLLSIPFFIMEAAYDKQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBS1</accession>
    <name>A0A914BBS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CTCK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073479.1">
        <property type="nucleotide sequence ID" value="XM_038217551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217551.1">
        <property type="protein sequence ID" value="XP_038073479.1"/>
        <property type="gene ID" value="LOC119741695"/>
    </dbReference>
    <dbReference type="GeneID" id="119741695"/>
    <dbReference type="OMA" id="MAVRCDC"/>
    <dbReference type="OrthoDB" id="10006958at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF13">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00068">
        <property type="entry name" value="GHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961936" description="CTCK domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="7">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="129" mass="14473" checksum="3E01049B2D4C0BA7" modified="2023-02-22" version="1">MATIRLTFGQYLAVLGILVVVVMNSRPCVSQLTCVPREYLVYEAQKSGCRAQTITTMACYGRCHTSEIPQLLPPYKVSDHDMCSYDQTVERQIQLSDCDPGVDPTFTYLDAVTCVCKRCQRDTTHCHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDQ8</accession>
    <name>A0A914BDQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073985.1">
        <property type="nucleotide sequence ID" value="XM_038218057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218057.1">
        <property type="protein sequence ID" value="XP_038073985.1"/>
        <property type="gene ID" value="LOC119742041"/>
    </dbReference>
    <dbReference type="GeneID" id="119742041"/>
    <dbReference type="OMA" id="YIMRPTN"/>
    <dbReference type="OrthoDB" id="1712432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="119"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="38674" checksum="A5FED6AF39FD0A1D" modified="2023-02-22" version="1">MASDHVFKVLFFIQSAAFTLFIINYSHISTVVLKPVGKLSAEKQCDCEPTGTREVFNKSAFVRQNGELLMPIRGQLSNCTLADIKKRPGVVMLTTANLAFVDIALNMLESVKRIGVCVNTTVIAEDQKAYDLLLKYAKGDPAIYVQKTNSGEMDEIEPSRRHGSHYYGIMNKRQAYILTLLEQGLEVLFSDSDTFWFRDPFPYFQGDFDISIRSFSKTRIISKTHFCSGFIYLKPTNATIQFVRTWVELMDNNKKKGEFPPDQRVMNGLLTADKPVHVNITILDEDLFPWGSTFFDPSWQKQNHSTVVMHAANIRGHPAKLSKFKEFGMWLVNVTTSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFE7</accession>
    <name>A0A914BFE7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074809.1">
        <property type="nucleotide sequence ID" value="XM_038218881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFE7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218881.1">
        <property type="protein sequence ID" value="XP_038074809.1"/>
        <property type="gene ID" value="LOC119742714"/>
    </dbReference>
    <dbReference type="GeneID" id="119742714"/>
    <dbReference type="OMA" id="SECTPSD"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="297" mass="32819" checksum="C10D2DF4079215AC" modified="2023-02-22" version="1">MATKSEPQNPDSGGSSGASPVSAVALKLPPYWPNDPVIWFAQVEAQFLTRGIKSELTKYSYVIASLQPSIAQEVRDLLVNPPADNPYSKLKEELIKRTSESERKRLQKLLTTEELGDKKPSQLLRTMEQLLGNNTLEPAILKQLFMQRLPTNIQLILASTSDVDIAQLAKLADKIVEVSPSPAQACAAVPAPALVAAVKPSAASEIQLLQAQVEKLTAQMELLVRQNQYQHGRSRSRSRDQSQHRRDRSSSASGDNPTDSCWYHWKYGDKARNCKEPCNYTRNHSSNTAQGNQQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGC7</accession>
    <name>A0A914BGC7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074918.1">
        <property type="nucleotide sequence ID" value="XM_038218990.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074930.1">
        <property type="nucleotide sequence ID" value="XM_038219002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218990.1">
        <property type="protein sequence ID" value="XP_038074918.1"/>
        <property type="gene ID" value="LOC119742810"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219002.1">
        <property type="protein sequence ID" value="XP_038074930.1"/>
        <property type="gene ID" value="LOC119742821"/>
    </dbReference>
    <dbReference type="GeneID" id="119742810"/>
    <dbReference type="GeneID" id="119742821"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="453" mass="51195" checksum="10439EC856ED6143" modified="2023-02-22" version="1">MAEGGVTDLVLDETQKELQECPICYTEYKDPRKLDCSHSFCLKCLQELKLTQNKDDKNIVCPLCRKETALTEAGVDMLPGGSKDVNQQEQTEGQGLKVMCQACDEAENEAISRCMDCKHYLCQECQKAHNRFAALKSHKIVALTELPVEPEEITEDTELKKVPKCREHPDQDLCLYCNTCEVLICNECTNIDHKGSIHSHVSIDQAKAEKEIAKIREKEQQLKMEARDIATKREKQFAYAVTSEKILGKVNKVMTTATCYEILENKKKMLRDLNEQVEVHKSLDIKHGKSFLGFKESKEDGQFGTLLLEEKWETDVAFSEYVQGRDYRHIAAYSTSEIAVVQSDKLLTLGIKGKVISTKTYKPDPDKPNEPHDPNDIQKATALAINKDDQLLILDNPAVKIFNKEYQLLHQFLPGKEAGVDGMPTCLAVDSSNLIAKHNLQQDKLPNQAFFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGI7</accession>
    <name>A0A914BGI7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075011.1">
        <property type="nucleotide sequence ID" value="XM_038219083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219083.1">
        <property type="protein sequence ID" value="XP_038075011.1"/>
        <property type="gene ID" value="LOC119742861"/>
    </dbReference>
    <dbReference type="GeneID" id="119742861"/>
    <dbReference type="CTD" id="10972"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="78"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="29391" checksum="B1494B2C2682D950" modified="2023-02-22" version="1">MQNRALPLPLVRLQHLDRRSFNFYGHFRIKEPTNDTEIQLMLILKMNATWLLAALLAVLSCTVTQVLCLSFMLPPNVKKCLQEEIHKDVLVTGDYKLSGAPGHKTLLLVKDDKGHILYQKDDAQFGKFAFTTDVYAVCDICFITNLPRGMRGADREVYLNVKRGVEAKSYEDIAKSEALKPMEVELRRLEDLSEAIVNDFAYMKAREEEMRDTNESTNTRVLYFSIFSMVCLLSLATWQVFYLRRYFKSKKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGV9</accession>
    <name>A0A914BGV9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075319.1">
        <property type="nucleotide sequence ID" value="XM_038219391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219391.1">
        <property type="protein sequence ID" value="XP_038075319.1"/>
        <property type="gene ID" value="LOC119743056"/>
    </dbReference>
    <dbReference type="GeneID" id="119743056"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="178" mass="20345" checksum="0E27CA1B188F0E06" modified="2023-02-22" version="1">MCFSHLFPIYRLNNTVTPLWNQPYENQLSTKQTNTREFLRNLSKMLQRNIGEMSPWLKQQRNSHSGMACELEPIKPSPVLESYRNKYEFTIGKSVDGIDNTVGFRLGAYKGLDPQDNHSTSTSDGPVTGASITDPYHYLTQQPFTSEIFKIEIQNLPRHFGFAPVLYATSVSLPWARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH89</accession>
    <name>A0A914BH89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">glutamate carboxypeptidase II</fullName>
            <ecNumber evidence="18">3.4.17.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.</text>
            <dbReference type="EC" id="3.4.17.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="18"/>
    <dbReference type="RefSeq" id="XP_038074787.1">
        <property type="nucleotide sequence ID" value="XM_038218859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074794.1">
        <property type="nucleotide sequence ID" value="XM_038218866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038074802.1">
        <property type="nucleotide sequence ID" value="XM_038218874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218859.1">
        <property type="protein sequence ID" value="XP_038074787.1"/>
        <property type="gene ID" value="LOC119742693"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218866.1">
        <property type="protein sequence ID" value="XP_038074794.1"/>
        <property type="gene ID" value="LOC119742693"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218874.1">
        <property type="protein sequence ID" value="XP_038074802.1"/>
        <property type="gene ID" value="LOC119742693"/>
    </dbReference>
    <dbReference type="GeneID" id="119742693"/>
    <dbReference type="OMA" id="QGSTEWV"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000089">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000002">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="20">
        <location>
            <begin position="236"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="22">
        <location>
            <begin position="421"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="21">
        <location>
            <begin position="688"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="817" mass="90619" checksum="03B7663FAB6402EC" modified="2023-02-22" version="1">MNPIRYDNRYEYLDSDSEAAMPGEEEDDQPTAEIHLTSPLRSDLEIRDPDAGVTVRSYRTGKSSPTMHLSNRTIVVIAALVAACVGIGIGVIIGWFSSQAQLPKVGSCETGWSDALKEEDSDAGTLLMNEMQAGNMKEYLRKLTSTPHLAGTPADKSNADYVRDEWIKYGLEPVRQNAYNVLLSYPSKEDPNYVSVLNSDNTQFFQSQAEEPPLDVGTLSNDTVRPFNAYAANGTVQGDLVYVNYGRVEDFQLLEGSLNMNVTGKIAVARYGKIFRGDKAKQAEAFGAIGLILYSDPADYAVDGISSVYPDSWWLPGSGVQRGSLYIQQGVGGDPLTPGYPSLDSAFREDESSIDMPSIPVQPIGYDDAKKLLDELEGAEAPEDWRGALQGLTYRLGPTLKDAKKVKLEVYNRNERRTVYNVIGMVRGSIEPDRYVIVGNHRDAWVFGALDPSSGTAVMMEVARAMGKLHKEGKFRPRRSIVFCSWAAEEYSLIGSTEWVEEFAKTLGGRAVAYLNVDIAIQGNYTFRAKATPNLFNALYQAAKQVPDVQDPGHLATVYDTWLDRNPWSDSKQLPHVLNIGSGSDYASFLGELGISSVDLRYDYNHDYKISSYPLYHSMYETFHLVSEVMDPTFNYHLATGRLWGELARSLADSLILPFDCQTYVSHLEESIASLKTKYTDQMSPQGITFDAIDAALAKLIQAADWLHDYISKMDMKDPFDVRKVNDQLMMMERAFLDPLGLPGRSLQRHVAFAPSSKNSYYGDAFPGIVDLMFDIENAEDSAKQWDLVRKHMSVVAFTLQSVASTLTGVDVLGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHC8</accession>
    <name>A0A914BHC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038074837.1">
        <property type="nucleotide sequence ID" value="XM_038218909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218909.1">
        <property type="protein sequence ID" value="XP_038074837.1"/>
        <property type="gene ID" value="LOC119742741"/>
    </dbReference>
    <dbReference type="GeneID" id="119742741"/>
    <dbReference type="OMA" id="ALWWIRY"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="210"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="561"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="667"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="581"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="773" mass="85639" checksum="43EF09368E4E1872" modified="2023-02-22" version="1">MDRSESSQKIYGITSPISLQGPKPEDLVYTEQLVEALKPHGVFENEEELNHRMVVLSKLDGIVKDWVREMSLKRNIPPNIAETVGGKIYTFGSYRLGVHTKGADIDTLCVAPRHVDRSDFFGSFQEILRAMPEVKDLRAVEGAFVPVIKMIFDGIEMDVLFARLALQIIPEDQDLTDDSLLKNLDQKCVRSLNGCRVTDEILNLVPNKENFRLALRAIKLWAKKRGIYSNALGFLGGVSWAMLVARTCQLYPNAAPSTIVHKFFLVFTQWVWPQPVLLKQPKPMTDLTFPVWDPRVNVSDRFHLMPIITPAYPQQNSTYNVTLSTKFIMEQEIKGGLAITQEVVQGTADWDKLFEPISFFQKYRHFIVLTASAGSVEHHLEWVGLVESKIRILVGNLERNSHIKLAHANPKSFNPQQTEEKTDIFASLWFIGLDFQQMDPSTNVDLTFDIQSFVDTVHRQAVGIGMLKDGMKIEAKHVKRKQLIQFLPNTILKFKKKSLQNQDSPSSTVSTELQQKDRKEPTTPTRKTGAAGAVIQPVQMTEEEFLYGAADENHSGIQLTKSASSPALGSGQTGQDRVEVTGSSSDTCVRSSNGNGQPTDTQPSGASTESSEASQENLVESTKESSQGGRISPSTEGVSVFKEPLSPESLQTAHPNKSLEVSLDSIDSTIDSGRGTPDEGSSSVKRPSSPEPSPLQSPPKRAKADTEQDDSTLTTTEDQSVQRNGQASVKTATLEPMTIDIRQRLPSGELPDMSSPMPKQVTLVKNSIKLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHM3</accession>
    <name>A0A914BHM3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075390.1">
        <property type="nucleotide sequence ID" value="XM_038219462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219462.1">
        <property type="protein sequence ID" value="XP_038075390.1"/>
        <property type="gene ID" value="LOC119743109"/>
    </dbReference>
    <dbReference type="GeneID" id="119743109"/>
    <dbReference type="OMA" id="MNCARIT"/>
    <dbReference type="OrthoDB" id="6081947at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036973793" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27523" checksum="0A5833D473812CAC" modified="2023-02-22" version="1">MAWFTPSSPCILFLISASLLRSQALPASCPPGWLEWHQSCYILLPDKMNWFEASEACNRPGSSLVVPNSREENLFIWKSMVEGAEGLWIGCTDAAQEGVWMCGGQAAQYTDWAVDFPSVNDEMNCARITVYNKGRWRHDVPCDIINDRKSAACEMPVFAAPAYHTFSGPAGRVPQQCLLHHDIKNLTVKGVLACGWACRADPRCRSFNLWQNSKREKTCQLNDVTRLGADRIDFAAVNDCYYFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHV8</accession>
    <name>A0A914BHV8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075679.1">
        <property type="nucleotide sequence ID" value="XM_038219751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219751.1">
        <property type="protein sequence ID" value="XP_038075679.1"/>
        <property type="gene ID" value="LOC119743352"/>
    </dbReference>
    <dbReference type="GeneID" id="119743352"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="23231" checksum="7DE555F88D4F067D" modified="2023-02-22" version="1">MEKLMLMSQHLNQMAHCQQVEELVGDLEALVGDLEALVELEMEKLMLMSQHLNQMAPCQQVEELVGYWEALVGDLEALVELEMEKLMLMSQHLNQMAHCQQVEELVGDLEALVELEMEKLMLMSQHLNQMAHCQQVEESVGDLEALVELEMEKLMLMSQHLNQMAHCQQVVELVGYLEALVELEMEKLMLMSQLLNQMAHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIN6</accession>
    <name>A0A914BIN6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038075765.1">
        <property type="nucleotide sequence ID" value="XM_038219837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219837.1">
        <property type="protein sequence ID" value="XP_038075765.1"/>
        <property type="gene ID" value="LOC119743437"/>
    </dbReference>
    <dbReference type="GeneID" id="119743437"/>
    <dbReference type="OMA" id="PHIYENH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="16 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1048"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="337"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="563"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="662"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="855"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126195" checksum="03CA5C83EE02D03F" modified="2023-02-22" version="1">MSKLLGETALCNKRLSSNLVSCQRFTEFPWLDRTGAGESPSAPGVIVITTMAAYLTRPYRASVLLFLIAVSLSKVISLNVVGKPATQSSTADSEVAGLAVDGDLNTYMQTAFSTAEEMTDPWWRLDLETVYCLRSITILNRQDNFCYIPERRNCGYRIIGAIVRAGLNPDHVSNRVIGTITEEQAIDTTRPIEIIANPVVTARYVSVDLRGTDRILHMREVMVGEYLYTEGGDGEVDFTLVTNPALLGQTGDDHATIAAYKGLYGISDDVSFGRQVTTGGSNDLPSGSNQLQHPLLGCRVRQLNLPEEGGIDRTGVFYCEATRADMTNTRIQTIILPKDGSVVHIRPVKRTQIANVGDSVRLEMQHVNAPNKNYRWRHNGRDILTSWNDQLIVSIDDVAVNDGGVYSCFASDQENRQLHGIMRLIVRGCSEGMWRPPSCLNTCRRCYNGGICDDKTGTCICAPGFSGDYCQVFGRNVFGQNAIYRCSDDCRGRLFCLRDPYGCSCAAGFAGPDCTQDCPEGTFGADCKQTCHCAPGDTCSKDTGECSNGVCASSYLGTNCQCSIRPVEVTPTSILQRSLAFSWQGPLCPNFGTMTGFVYKLTDVKSGPHVPPLFNAIKQTVTIDGLMPYTVYSFQVAAITCAETTMYSEPINVTTLEAEPSAPPNVNIQNIDDVSITITWSPPNSPNGIITNYDITYWKSVDAGTQTLRNDVGVSPLVYCVDGLEISTRYRVQVRAKTSAGAGPWSDTVTAFTQIGAGATDAPNNGHVNVAAIILGVLLAIAVIVIIIGCVVWRKRNSDSAPKLDDQLIELSNVRHPSTHGIESPIIEDIERDINEDIGLPSWATGLEIQWQNLTIEDKVLGKGIFGEVRAGSLEIREMSKVAIKTVKGATTTASEDFLVEFKTMSKIKPHPNVVGLIGACIHKAVLYIALEYLPNGNLRDYLRSTRPQQQVTMKSDDGVSPLTSSNLLTFGIDIARGMDHLSDTGIIHRDLAARNILLGEDLTAKISDFGLSRGEDIYFQKSKNRVPFRWLAIESLTRRMYKSKSDVWSFGIVLWEIATFGATPYPGIQSKLLAKRLQEGYRMPKPENCADEIYDLMMKCWQAHPSQRPSFAEITAALEKMNDPSDETMYLIPYVDVNHVIKPEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJD7</accession>
    <name>A0A914BJD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="RefSeq" id="XP_038075941.1">
        <property type="nucleotide sequence ID" value="XM_038220013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220013.1">
        <property type="protein sequence ID" value="XP_038075941.1"/>
        <property type="gene ID" value="LOC119743601"/>
    </dbReference>
    <dbReference type="GeneID" id="119743601"/>
    <dbReference type="OMA" id="HPRAYIT"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036896098" description="Alkaline phosphatase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="533" mass="58167" checksum="0C542579CEDE2AD0" modified="2023-02-22" version="1">MRFTGWTMIWLLLCLAFAGCTWAQNAQFWNIQAQDTLQKALTREASLNRNVAKNIVFFLGDGMGVSTVTAARIMKGQQAGMTGEETVLSWEKFSSVALSKTYNTNRQVPDSAGTATAYFCGVKTKEEMIGVDDQAVLGDCQSSLNAAVDSVMTDAEKEGKATGFVTTARVTHATPACLYAHSPDRNWENNADVPEAEAALGCTDIAHQLVTLGQNIKVIMGGGRREMLPDNFTDYEYSALTGQRTDGRNLVDEWLASKDAQTSHFVWNLDQFNEVDPENTEYLLGLFESSHMQYEGERTNEPSIAEMTEKAIRILQKDTDGFFLMVEAGRIDHAHHDGFAGNALNDTVAFDAAVAKAVELTNEEDTLIIVTADHSHVMTLGGYQSRGNPILGLVDLSSAEDDLPFTSIGYTNGPGGIAEQVSYKLFGRRRNLTDNDTENPRFTQPGIVPRESETHGGEDVAIYANGPMSHLFHGVHEQNYIAHVVRYAACLGNRQHCDEYVAPCGSGASSVPSGGVTMITVLLNLWLALVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJT1</accession>
    <name>A0A914BJT1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038076359.1">
        <property type="nucleotide sequence ID" value="XM_038220431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220431.1">
        <property type="protein sequence ID" value="XP_038076359.1"/>
        <property type="gene ID" value="LOC119744491"/>
    </dbReference>
    <dbReference type="GeneID" id="119744491"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037815737" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="141"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="275" mass="28344" checksum="A75DE400605B4DB9" modified="2023-02-22" version="1">MKICVATILSIALLLGNSVKLRASVTGPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPVGPMGPFGQPGSKGDAGQQGEIGPIGSMGERGAPGNTGSNGNDGIGLPGKIGPRGLPGFVGGTGETGVKGQKGEPGETPDYSNQRVAFTVVRTSYSDTSTTHDTRLPFQQAETLLPGTSFNLETGTFTCSVSGTYVFTFSVLKFSNSGNLYIHLVKNDYKVISTYGESNQRGQLSGSAVLVLQRGDTVYLTMYGRAQSSSTSHYTSFSGFLLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMH5</accession>
    <name>A0A914BMH5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077145.1">
        <property type="nucleotide sequence ID" value="XM_038221217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221217.1">
        <property type="protein sequence ID" value="XP_038077145.1"/>
        <property type="gene ID" value="LOC119744992"/>
    </dbReference>
    <dbReference type="GeneID" id="119744992"/>
    <dbReference type="OMA" id="SEHECKT"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="35679" checksum="5D5C6AFFC7751828" modified="2023-02-22" version="1">MNPQSVNFTELLNGEPNPQLDPLEVSFGVLTALTVVLILTLNPICVVMLHRASGIQETTKVFMASLTVSDICIGLFWVLPELTQHFNRKWVLGSFLCTVWGVTSTYLGGLSMFSLVLMTVDRFVAIVYSLRYPTLMTLKKAKTIVAITWSMTLAIGIIAFGIFLPHVISPSAPRKCIFTSDNNIYTSIVVSAIAISLVTIVILYMYILNVARQQARRIAAQNQINVDLGDQNAPQRVSTKSATTVFIITMTVFICWLPSIIFSVISLTPGVQPPPLFKLITNFIFATNSWLNVVVYYMRNRELRQALQELVASCFRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP00</accession>
    <name>A0A914BP00_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="11">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038077431.1">
        <property type="nucleotide sequence ID" value="XM_038221503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP00"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221503.1">
        <property type="protein sequence ID" value="XP_038077431.1"/>
        <property type="gene ID" value="LOC119745267"/>
    </dbReference>
    <dbReference type="GeneID" id="119745267"/>
    <dbReference type="OMA" id="HIGAGTH"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="15">
        <location>
            <begin position="115"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="16">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="451" mass="52263" checksum="82F2C04AB703F698" modified="2023-02-22" version="1">MPGMFNADVLTGTRRLFYAVTPNETSFERLEDVPDYFYEAIPFFGLMSLIEMIVTISDKKVRERFFLADSISSLSAGMLLLLTAFLAYGVNIGMYVWVHEHYRLATLPWNSPWTWVICFVLVDFGYYWMHRMTHEVNIFWAAHQVHHSSEEYNLTTALRQSICQRFVSWMFYLPLALAIPPPMFMMHQQFNTLYQFWIHTRAIKSLGPLEYILNTPSHHRVHHGRNRYCIDKNYAGTLIIWDRMFGTFEPESDPVVFGLVHPLESFNPLYTQYCHFKYIVETAWNMPGLTNKLWVFLKGPGWTPGLPRQGSIKDIPDIHYPMPKYRPKLPRWIFAYIIAHFAINFIVYDAFMTSRTTLSPTATFCSMAYIILTLTCLGAIGDAKPAAPFLEVVRSCLVLVAEAIASSYLPIMQRGSSQWVFYLLRAAFGLSIVVWLPRCVSVLTQRKNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRG0</accession>
    <name>A0A914BRG0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078883.1">
        <property type="nucleotide sequence ID" value="XM_038222955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRG0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222955.1">
        <property type="protein sequence ID" value="XP_038078883.1"/>
        <property type="gene ID" value="LOC119746149"/>
    </dbReference>
    <dbReference type="GeneID" id="119746149"/>
    <dbReference type="CTD" id="200185"/>
    <dbReference type="OMA" id="ITIYYMN"/>
    <dbReference type="OrthoDB" id="1111004at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036861263" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14220" checksum="F29C2D57DD5BD632" modified="2023-02-22" version="1">MAVSTSISFLLASLLAVSTFAGMQMFKVQLAASEWMTILGGFLGSVLFALTLTGVGNLESLLFGKGFQMKIFPEVVLCLGMAMFASGLVHRVCVTTCFIFSLVDLYYINKLAQTKHAPVVSVQQTQGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYN2</accession>
    <name>A0A913YYN2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044497.1">
        <property type="nucleotide sequence ID" value="XM_038188569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188569.1">
        <property type="protein sequence ID" value="XP_038044497.1"/>
        <property type="gene ID" value="LOC119719205"/>
    </dbReference>
    <dbReference type="GeneID" id="119719205"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="6">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="159"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="703" mass="79987" checksum="6D8C0FBF7CCBCF99" modified="2023-02-22" version="1">MSCFTACCRGGSSTDDTDGETGVKLMEGKSDDNLAGTHSKYTILVKTGDRKGAGTDANIFIILHNENQVASKEIKLDKLFRDDFERGKTDEFKTKLPAEFGAVAKIELWRDESGAFDPWYLEKIDIFEVPKEGDKKGPYVFPVHRWIPAKKRVMFHQFDSMLPQNDPLKDTQRKEEMQEIRETYKFTSQAPEAGLPCQVAALPSDEKFSFDYLFDIAKRKANLLLQSKLSKIFTGKWESLDDLSNVYHGKFPKPAGMHMWRSDIEFGLQRLIRCNPTQLKLFTEVPEKFGVTDELVAPFLEGMTIQEAIEKKKLYYVDYEILLKLPVKQGTPVVSPIGLFFVDKDKHLIPVALQLEQQKAPDNPIFVPSDPEYTWLLAKMWFNFADASYHQSATHLGLTHLAMESVAATMHYSLSPSHPLFRLLAPHFLFLMAINSRGLALLISVDGWVDKTMNIGRDGMFDLIGRAFKKWRLNVEGTLPNDLKNRGVDDTEALPNYHYRDDALLIYDAMKKYVTEVVEAHYETPEMIVEDYELQEWGRLMNTPQDEGGVGVQGVPADGKFATVEDVISTITPIMFTCSVSHGVANFSQYDDYAFPPHYPAGMRMPPPTDKSPRTEKDILDNLPDKNVTVDVMTVTRLLSEKATKSLGDFEVQYGFCPIAVKALEEFRKELKHIGIMIDERNRYREFPYDYCHPNEVPNAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZZ7</accession>
    <name>A0A913YZZ7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045148.1">
        <property type="nucleotide sequence ID" value="XM_038189220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189220.1">
        <property type="protein sequence ID" value="XP_038045148.1"/>
        <property type="gene ID" value="LOC119719721"/>
    </dbReference>
    <dbReference type="GeneID" id="119719721"/>
    <dbReference type="OMA" id="WTIYSEL"/>
    <dbReference type="OrthoDB" id="10045093at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="387" mass="45718" checksum="F878FBFEA1FB3908" modified="2023-02-22" version="1">MDDMDELIKKYFKLGYSQVEIAATLTSRYNINLSVRQLQRELQRLELYRHKNQTDMAQVRRFIERQLQASGELHGYRWMHHKLLQAGMVASRETVRRTLLELDPDGVNLRKRRRLVRRRYSGRGPNFVWHLDAMDKLKPFGIGISGCIDGFSRKIIWLEANSTTNDPEYIRGFFLKAVDRLGGCPTLVRSDRGTENGHVGAFQRFLRHHDDALGGDKSYLTGRSTANQRIESWWGQLRKQCTEFWRTLFRWLLEEGFFTGDVMDKELIRFVFMKHIQGDLDAVAEVWDGHLIRKSKQEHVTHGRPLLMFQLPEVYGTRDHLKPVEQERIDLCREECNFKDRFPCDRELFEYCCQSLITNGWEDPRKPEAAMNLYINLREHVRREIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0G1</accession>
    <name>A0A913Z0G1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045399.1">
        <property type="nucleotide sequence ID" value="XM_038189471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189471.1">
        <property type="protein sequence ID" value="XP_038045399.1"/>
        <property type="gene ID" value="LOC119719981"/>
    </dbReference>
    <dbReference type="GeneID" id="119719981"/>
    <dbReference type="OMA" id="CDEYYGE"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF28">
        <property type="entry name" value="NANCHUNG, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="465"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="754" mass="86486" checksum="430D76DC97666C6C" modified="2023-02-22" version="1">MKADVKYGNCDSHANVCMEIYELYEDLVDLAREAGKSHLAQAAFEEKIRGPEISKFLYEGGNGKMVPIKTLVKIRNQDNWIDNDVVDAKDRKKKRRPISKSKKVTGSLGSTNKVGSEQEAQREFCWDIDRRGYSGETLLHVCFMSPHNKDVNFEIAKHLIKAWPKMINDFILGTESYGETCLHKAIVNENISMIKFLIENGADLNVRCYGRFFRPDDQKAWCVDSLEHEHFILYKKTNYEGLTYWGETPLTFAACLDLNHVFRSLWVKGCDINTQDTNGNTVLHMMVLQDKKDMFTLAYELGGDCTIKNKQGYTPLSLAAKLHRIDLFEHILFLERQLSWKYGSVTCASYALDGLDSINYDGSINNKSSLHLIVNQTSKEHLQMLKGVIYKLLDEKWKTFGRFNFCARLAFFLLYLAVITTAFYLRPGKDPRAFTVSDNVTQPNGSVIVAETEITEPCYLLYTDTPTDQARVVFEIITLIGSIIYLFYAAKELYHLGKWSFMDLMILAPAKAMFLLSCCFVVLACFGRIPPCNPYYEDVFITFAILTACPYSLFFLRALKLVGPFIFMIYKMIHGDLLKFLAIYLIFLFGFSQAMHIVFLGYTGKFELLDSVIGMFVMSLGEFGDIYATFDETRYPIMGKFLFCVYMVLVALLLVNMLIAMMGSTFSTIAETENEWQRQWAKIVLILEQSLSPAVRVSILHKYSTPMWDGRQDRAMIMQTENEDHDDTTIQKSKHRHNVNSNREFIDGEWQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z394</accession>
    <name>A0A913Z394_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM124 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM124 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046177.1">
        <property type="nucleotide sequence ID" value="XM_038190249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z394"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190249.1">
        <property type="protein sequence ID" value="XP_038046177.1"/>
        <property type="gene ID" value="LOC119720544"/>
    </dbReference>
    <dbReference type="GeneID" id="119720544"/>
    <dbReference type="OMA" id="RCFVEIE"/>
    <dbReference type="OrthoDB" id="10011619at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029380">
        <property type="entry name" value="FAM124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046365">
        <property type="entry name" value="FAM124_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715:SF7">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15067">
        <property type="entry name" value="FAM124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM124" evidence="2">
        <location>
            <begin position="222"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="45109" checksum="BD0FE31B61E1C789" modified="2023-02-22" version="1">MAQSHQDESDGIFLENELPSSKDEADYSLSVVNLTRAADIPLRYFLPKIFSPMEASMTRSCQRVSEKSPKYRLLNTDWGNRMSSVKEGPGILALVTVEKKSLDEHSVGKVESHIKKLMKATSCQLLRWDAQHILLYFEAGNDYDTFGRLFLDEKLDNCEGFRVNAIEPSILTNPPRCFVEIETMQGTQTRDTLTSFIGNFSGAFKHVNILEIQRLFPAGSAGDAKQGDIPRLAVTLMFSGRAQSRAVEVIKVLSAGDQWKPYQLPEPVARELEDENTTYYQHAALSLPLWGVKTGATSSGVRVTLFVKGGTDFQQMEAFYGKVTGVSPLQQNGGAAAKWSTFPLSNRLEFTLAFYQGLSPRASENHLLYFQTNEQAIGAEKLAEDHWQLKDPENNTAVLFTTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3F1</accession>
    <name>A0A913Z3F1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045235.1">
        <property type="nucleotide sequence ID" value="XM_038189307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3F1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189307.1">
        <property type="protein sequence ID" value="XP_038045235.1"/>
        <property type="gene ID" value="LOC119719812"/>
    </dbReference>
    <dbReference type="GeneID" id="119719812"/>
    <dbReference type="OMA" id="NSICKGW"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF11">
        <property type="entry name" value="ALPHA-TYPE PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34448" checksum="B973CEC42CEED531" modified="2023-02-22" version="1">MGSNQSNTSKVIGYTSAWVEFEDDWFDQGASRYAYKGTFHGEPHLEGKPCVVKVYKEEWYERMSEYAWKADDRAYCKAHDMARLFNIRYNTSKPIEFVKPEFTQVDTRAAYNFLGFIPFERNVKGKLPGTSDSVSNIIPANATLAVERYLEGDYVKFNNNSGYLAREDIATPAAFSHFTYHESNGTALVCDLQGVRSRAGYKFTDPAVSSSGTQLGFYGSTDLGICGIVKFFKNHRCNELCKGLKKPKITNLSLGERVVLAKIVDNMPSHSASTHTYQLSLSSGVSTRDINRIQNNIRLEAVSEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4R4</accession>
    <name>A0A913Z4R4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045996.1">
        <property type="nucleotide sequence ID" value="XM_038190068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190068.1">
        <property type="protein sequence ID" value="XP_038045996.1"/>
        <property type="gene ID" value="LOC119720404"/>
    </dbReference>
    <dbReference type="GeneID" id="119720404"/>
    <dbReference type="OMA" id="YYAKMAQ"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000109">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000178">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000298">
        <property type="entry name" value="ArfGAP with GTPase domain, ankyrin repeat and PH domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF5">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="340"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="13">
        <location>
            <begin position="594"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="753"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="843" mass="92405" checksum="E7572D25BA372920" modified="2023-02-22" version="1">MPHQPSALTMSFRRKKRNKQLRKTRCYSEINYDSFVNSQEWTLSRTVPELKLGVVGSLTSGKSALVHRYLTGSYMQEESPEGGRFKKEIVVDDRSYLLLIRDEGGPPELQFCSWVDAVILVFSVEDEMSFQLLYNFYAKIAHYRNTADLPMILVGTQDTVSQNTPRVIDDSRARKLAADLKRCPYYETCAMYGLNVDRVFQDAAQIIQERKHQQFLSLGPLSTSSSSLPSTPHSVRSNNFGIPGPYPQGTANATAPSTNHSNSGAPPTPTAGRRNMSGGSREGSRDSSQPSPSSTPNFTRKSRRKSNLFTQPGKGKQAETKNGAEPVPRPSHGIGSGRSIPIMQGLLYKRSSKSLNKEWKKKYVTLCDDGKLTYHPSLHDYMNNTHGKEIVLMNTTVKVPGRKPQIVRSNPGGSPSKSAPGSNGIANNMRAMTITGGSTHANQAAFAKDGGVNFHSFKERQEINAKSTSLPRDAMLDSVVISNSSVTPGISNGMDAPMAFPQMGNLVGGKESSKKKHRRMRSSGGGKNLDTSNQQEDTDEYEFVIVSLDNRQWHFEVSSAEERDVWVTAIEQQILACLQANVSAKGLMTNVERSAAVEAIRKVRGNNQCVDCGVPNPDWSSLNLGAIICIECSGIHRNLGSHVSRVRSLQLDEWPPELTAVMLSIGNATANSVWEGSLRNRTRPAATACREEKEKWIRAKYEKKEFAAPPPFTDRPLGVQLMEAVIKEDVRSVILVLIHASQDDVNYHYGEGDGRSALHLSCAMGNVVIAQLLVWYNADVKAVDADGRTALAYARSVGADECIKVMLANGCPDDGGGDMNINNSALRRSHGRGTPNKLASSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4R9</accession>
    <name>A0A913Z4R9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046001.1">
        <property type="nucleotide sequence ID" value="XM_038190073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4R9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190073.1">
        <property type="protein sequence ID" value="XP_038046001.1"/>
        <property type="gene ID" value="LOC119720406"/>
    </dbReference>
    <dbReference type="GeneID" id="119720406"/>
    <dbReference type="OrthoDB" id="9945342at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037938665" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19527" checksum="094B2D7840DFB22F" modified="2023-02-22" version="1">MATFKTSSVLFIICFVLSGTTDHGSMVLGCAPCNTGWIEFGNRCHLIVNKQKSFQDAEAYCQGLSRPGRPAHLMSINSEKENDFLMEYAKTINGLVEMSWLWIGYLKSATPKWLDGSQDSYVYWAPGYPLSWPIETIDLVCVGVYIPVGTWVDLYCITETAFVCEMPYRFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5H3</accession>
    <name>A0A913Z5H3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046025.1">
        <property type="nucleotide sequence ID" value="XM_038190097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5H3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190097.1">
        <property type="protein sequence ID" value="XP_038046025.1"/>
        <property type="gene ID" value="LOC119720433"/>
    </dbReference>
    <dbReference type="GeneID" id="119720433"/>
    <dbReference type="OMA" id="HESTIVP"/>
    <dbReference type="OrthoDB" id="10064617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="517" mass="56998" checksum="7C4B71E717279943" modified="2023-02-22" version="1">MAVSAMHRDRAMEVQFEEQTAPKSLFTKLHDIGVVAKDHLAAIQPLPGNKFEIVYKSSVLCKEFYPKVTTLDKCTVTKFNDVMIVTVHYVSLSMHDSIVRNILGRYGQVIAGRFTTYGDNPTVFNGTRQYRMRINKPIPTVIRIGDRNAWISYPGQIRTCARCGQEGHFAKECNNIKCFKCLQVGHIANECPNSTVCTICGEEGHGFRACPKSFANKVQPDRAWSTSSSTPSAAAPPAAEERPARESPRSEPSEPDKELPITPCSKCKRPSGPFHPSICCFSCKSTISCDSPFRVLECALCKGMNGPPSLVCDREDCRNVQAPERDDGFRLARKKKRPTKRARSPQEAPSSKRATPTTTEVFGSDLESVSSMDSTPPKEQAKTGSSSASNAGSSSSSSSSDASSESEQEQDSTDNDEASGVNPMKIGKVLNHLTRLKLPGLSEPARCRAPKCLFTCQTWSGLSRHTSSVHNDSSLTQVKCPWCPHSACLPTRWTRHIARQHPDKALRKKADFFKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5Q0</accession>
    <name>A0A913Z5Q0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038046115.1">
        <property type="nucleotide sequence ID" value="XM_038190187.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190187.1">
        <property type="protein sequence ID" value="XP_038046115.1"/>
        <property type="gene ID" value="LOC119720503"/>
    </dbReference>
    <dbReference type="GeneID" id="119720503"/>
    <dbReference type="OMA" id="HAICAGE"/>
    <dbReference type="OrthoDB" id="5988713at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206:SF1">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206">
        <property type="entry name" value="PROTEIN CBG10425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="825"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1663" mass="191675" checksum="66B9F0EF018EDEB1" modified="2023-02-22" version="1">MWTLTSSHRSRVSSKCPINCNVYNNTCTSTFVEEWYEFCLYINNFFPHITQIPSSFKMSHQGAMKPFPTSTPPSDQFLRCLQEEWDIDQDEDQLMIVDVPPEPSAAVKQQGLQDGRGGQEQGERAAKGGRYPCGTCGKVFRQLTNLIRHRKLHESGPSVNRKAVTCPVCNKVFSRPDNLKRHRKNHSADQLPSTTRQISGQESAGSTIAEAGTDCNPPQAKSPSITKSTCSACGDVFQRVSHMLRHLQNDHRGVSASYPISFEPNPEPSQFVSENKEDPDMMEADPNVLTSTSPTGVPLPSPPQASQGHICPLCDKSFSRHDSLRRHIKTYHESGATPPSIHEEPLSHQISRPESPETVPEDPREFPADDFGEENLQEADDILKALRRHWLPIRTHYTTGRRIQDVYNFRLAGNSTIDVDLALRMIFQRLRCRVKINLSFGFILRHSETGQLRYFHASQNNARLFSTPETVATEQDMDRVRERVRETDILQYGILRRPDTKWTVAATTNVTVYVNKMPQFPIGSPVEKLPHYVANNRGLTNLLRNTNTGKMLDDNFCFFRCLAVHRGTNSHSTEKAVHHLVETYRQAAGKDRVDGITMDELAIAEVVFKVNVQVYTLLPAEIDDDDDDANEVDKMTGEEQCPNKPTIQVELIRRSHRRYPDTLYLNLWGNHFSYISDLSKYSRSYACSKCNTVFTRSWNLMTHEITCDVNVKHKFSGGSYQLPLTIFDKLSEVGIDVEEDMKYYPYRATFDYECYFQSVSPSMRQRDAKLRWEARHELLSCSIASNIPDYEAPRCFVSNGNPRELVSDMVDYLHTISLAAYDTLLEKYEVIFEKMDEMIEDMQSESMPQSKLHKHINKLREQLDEYLQELPVLGFNSGKYDINVIKRYLYPVLQETDPLKLIIKRTSTYMALKTEKLKFLDITNYLAPGYSYAKFLKAYDCPLTKGFFPYEWVDDLDKLEVGSLPPHQAFYSKLKGCNISEEEYQYCQSVWKEHSMNTVRDFLVWYNNLDVVPFLDAVDKMFAFYRQRQMDMFKCAISVPGLSLHYLFLTLPKDTFFSLIDEANKDLYYKLKDNIVGGPSLVFHRYHEKGKTFIRGGTKLCQNIVGFDANALYLWSLMQEMPVGTCIRRRADQDFKPIRSHKFGVMATEWLDWVAHCEDVHIRHQFNSTEKRVCERMIPVDGYCSDTNTVYQFHGCYWHGHPCHLNPNEFNKVRKVSRDDLRRQTEETSAYIRQQGYNLVEMWECEWRQLQATDQTVESFLQTSRLPHCGKANMTQREILEAVMDGSMFGLIECDIQVPEASRDHFAEMPPIFKNIDITRNDIGDHMQSYAEREGIMNTPRRSLIGSMFGTRILLATPLLQWYLNHGLEVLHVHEVIQFKKNKCFEAFGDAVSDARRAGDSDPSKAILADTMKLLGNSAYGKTVTNQERHMNVRVCNDADAPRYVNKSHFRALHALDDDVYEVDMAKKMIRLNLPLQIGFFVYQFAKLRMLEFYYDFLIKFVHPSDFQMCEMDTDSAYLAISGNTLDDVIKEEMKEQYLREKHQWFPRDDTAPHRAYDKRTPGLFKVEWEGDGIIALCSKTYYCFGSKNKISCKGLNKANNDITKQQYMEVITSQTASGGVNRGFRMQHDGMYTYEQVKTAFSYLYPKRKVASDGVSTSYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7U9</accession>
    <name>A0A913Z7U9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038047802.1">
        <property type="nucleotide sequence ID" value="XM_038191874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7U9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191874.1">
        <property type="protein sequence ID" value="XP_038047802.1"/>
        <property type="gene ID" value="LOC119721921"/>
    </dbReference>
    <dbReference type="GeneID" id="119721921"/>
    <dbReference type="OMA" id="PFYVWDL"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="294"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="403" mass="45410" checksum="AE7C1EE5CBED6322" modified="2023-02-22" version="1">MPIARFKHIVCAISGGVDSSVAALLLKSKGYRVTGLFMRNWDALDETGVCTADQDEEDAQYVCQKLQIPFHQVNFVKEYWHDVFSELLKQYQGGITPNPDILCNKHIKFDRLLRHSRDVLGADALATGHYARTDVGETILDRDWQSKPQPVKLLQAVDSTKDQTFFLSQMSQHALQRTLFPIGDLTKGVVREIARGAGLERIVKRKESMGICFIGSRKFKPFIKEYLEPTPGNFVSLEDNKVVGTHEGYFIYTVGQKAKISGMKEKWYVVDKHPTSNEVIVVPNTNHPALYCETMLTGPVHWIREAPRQLLQEQMMDCHFRFQNTDPLVPCTLTMSSMGSVIVSLSQPLRAITPGQYAVFYLGDECLGGAVITKPGPSLFMLRNRQYRPVDGRASVKTHNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z829</accession>
    <name>A0A913Z829_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047161.1">
        <property type="nucleotide sequence ID" value="XM_038191233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z829"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191233.1">
        <property type="protein sequence ID" value="XP_038047161.1"/>
        <property type="gene ID" value="LOC119721249"/>
    </dbReference>
    <dbReference type="GeneID" id="119721249"/>
    <dbReference type="OMA" id="CIITYEI"/>
    <dbReference type="OrthoDB" id="67296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="281" mass="30968" checksum="8E645E1594CD95E7" modified="2023-02-22" version="1">MGALFALCGTFKMAAPMAKIFPSVQFPLPTNGSDEKDSEYEFRNAVFMIQSPLKSRRCLLTGKHGSGKTSLLFQCAVSCALDGQKVVFISHRRFQSMPLSVHGAPSPDPLLMKHIHILYYQDRPSLLQYLAGIHSVPSPPDVILVDDIDFYATHPKTQDTGSTTALLCAYLIDAGAFIDTHRANNQTRGRENDQRCQLIASVTTPSSGEVALEHVYQSFLPTFLRISGVQGTNEVYQLSLHPNGTSQATCIITYEIRDSIRLLDYHVGDAALGLSQDFTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9G2</accession>
    <name>A0A913Z9G2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038047525.1">
        <property type="nucleotide sequence ID" value="XM_038191597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9G2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191597.1">
        <property type="protein sequence ID" value="XP_038047525.1"/>
        <property type="gene ID" value="LOC119721520"/>
    </dbReference>
    <dbReference type="GeneID" id="119721520"/>
    <dbReference type="OMA" id="NEYESHK"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="365" mass="42461" checksum="5E0AAB12FC627CF6" modified="2023-02-22" version="1">MADVQAMFHQVKVTHEERDVLRYSWWSDGDSSRQPSVYRMTVHSFGGTWSPSCCTFALQRTAEDNRADFQPDAVDTVMQLKQEASDWPSWCQSDEQKHQYIQQYLDKEGIHLEWDKIKKNPGLRAIAKLMLNSFWGKFGQRPNMSKTTYVKDPTEYLDMMTRDGLEIQGVNFVNDEMVEVQWQNTGEFVESSGRTNVILAAYTTCQARLKLYEVLEKLDQRVLYYDTDSVIYVSRDGEWEPETGDFLGELTNELESDNHIVSFVSGGPKNYAYKLARPDKGGYLTHCKVRGITLNYRNQFLVNFDTVSQMVRNEGPKRVQVTDPYKISRNKKTINIETKEAKKHYQVVYTKRVPLENYDTIPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9I7</accession>
    <name>A0A913Z9I7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Josephin-2</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Josephin domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038048299.1">
        <property type="nucleotide sequence ID" value="XM_038192371.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065706.1">
        <property type="nucleotide sequence ID" value="XM_038209778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9I7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192371.1">
        <property type="protein sequence ID" value="XP_038048299.1"/>
        <property type="gene ID" value="LOC119722323"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209778.1">
        <property type="protein sequence ID" value="XP_038065706.1"/>
        <property type="gene ID" value="LOC119735840"/>
    </dbReference>
    <dbReference type="GeneID" id="119722323"/>
    <dbReference type="GeneID" id="119735840"/>
    <dbReference type="OMA" id="QRNCEAV"/>
    <dbReference type="OrthoDB" id="422700at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000003">
        <property type="entry name" value="josephin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="180" mass="20563" checksum="470F6FDD959F3D58" modified="2023-02-22" version="1">MSVYHERQKWELCALHALNNVFQDSQAFSKQVLDELCQNLSPGTVLNPHKSMLGLGNYDVNVIMAALQHKDCEAVWWDKRRCLEALRLEVLIGFIVNIPSPMQLGFVSVPLRRKHWIAVRQIEGTYYNLDSKLSKPAKIGDSSKLRGFLEAELRRKGCELLLVVTKEVAEAKTWLRDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9L0</accession>
    <name>A0A913Z9L0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047575.1">
        <property type="nucleotide sequence ID" value="XM_038191647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9L0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191647.1">
        <property type="protein sequence ID" value="XP_038047575.1"/>
        <property type="gene ID" value="LOC119721568"/>
    </dbReference>
    <dbReference type="GeneID" id="119721568"/>
    <dbReference type="OMA" id="CAYICLL"/>
    <dbReference type="OrthoDB" id="6123456at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="498"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="770" mass="88419" checksum="1893DA3F81CE49F0" modified="2023-02-22" version="1">MPLLVAMIQASLPAKLKRAGHNIIEKRLGTILSIIFFTRAPRKYNFVQATLSVELWRQGCTHKLFQTLNRLGITQGLQTARAHVDNIAADHDNCLVQWKTSVESSDNRNHKKAVRRVSQTGDEGYGVCWDNVQINPHCKHQGKDKKAEFLLWALSFACNNRVPTLHLMDTTTIPACQLIPCIIPQHHDYAELKNLMVYLTMKILMQHLPVMDPMKRHVPRRKHQYSTEMCNKSEVVNLGVLEANPASTAGVIQIMQHLHAYVPEPNGQVLPILCSGDGLSVERMVHAKRARVNGESKMHRLQGLVETPQEFHKEILLLQDTVNMLYSGSSIASRGSLAHMKVFYNHRSMSTDVKQNVQHAWDLIEFTTEAYVTMFAKTILNLDTISDVPANFPSTGRMEEKVEYLRRLAEQIVDFCWLAPKKEDIRKVNASAKSSAIFPEESYGFCCCDEEKEEPMIQCCSYQCPFSWYHLACVGLDEAPTDDWFCCDDCEVDGTYIYCRCHKRKGGEMIQCALKDACRNQEWYHKSCLSDNTFPEVWYCCDECALETEHDDYVLNYTKALMWRGLNHLARRFAVRHGEGETMKSHWKMDLLEFWSSRHHKYLNIAQQFLTGVSGFLSERLRHDMTWNRVANVHGKEGANIGMDLLNEFLNNEFKDMLLRSRGRYTPKQVQRCAQMSGAFGKQIDRLITDGGLGDLVQGNGSKTRHANKKDVLDFVKEFQKDLLFVYHPGRYHRGFEEYAYSTGIKSPDLLGRKLRKTAEVMDMWKNITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDB5</accession>
    <name>A0A913ZDB5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cholesterol side-chain cleavage enzyme, mitochondrial</fullName>
            <ecNumber evidence="5">1.14.15.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CYPXIA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Cholesterol desmolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Cytochrome P450 11A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Cytochrome P450(scc)</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; C21-steroid hormone metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.6" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038049504.1">
        <property type="nucleotide sequence ID" value="XM_038193576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDB5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193576.1">
        <property type="protein sequence ID" value="XP_038049504.1"/>
        <property type="gene ID" value="LOC119723077"/>
    </dbReference>
    <dbReference type="GeneID" id="119723077"/>
    <dbReference type="OMA" id="GPQTHVN"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008386">
        <property type="term" value="F:cholesterol monooxygenase (side-chain-cleaving) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006700">
        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF3">
        <property type="entry name" value="CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="13 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00032666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="592" mass="67113" checksum="77F5770E45F8678D" modified="2023-02-22" version="1">MTGRQVPRIFASASRLRSLRHPASTMAVPRERSTPQQMEETRSDRSTVQMHQLNKVVVDMPSGNPNEPTDSTVNSVAESWGTCPAGLGTTTDAAPVPVEHIKTPSANGVHTHVQSFDEIPGPKGWPFIGTLGTYLVGNGLSRIYEHQIAFTKQYGPIWKERLGSLEFVNLADPELVSMMYRHDNKYPMRVDMKPWKAYRMHRNESLGVLTHEGKQWHRARRLLSKKILPPKTVGAYVGVINEVMEDMIQRLRYVRDVTNQDGLVPELTNEMYKWSMESIFKILFETRIGCLDKQIPAESQRFIDSIHQMFISGQILFVTSPEFFRKYNLKPWRDHEAAWDYIFSFARKAVDNRLAEISAQSEGEGELEADGFLTYLLSSKQLSMKEIYSNACELLLAGVDTTSNTLAWVLYELSRHPEVEERLHQEVCQVLGSDKTRKANTEDLAQMPYLKSIIKEILRLYPVVPANNRILEKDIVIGGYHIPKKTIIGSLQYVIGRDPKVFEEPNSFRPERWLRDNSGRMHCSNSSFASVPFGFGPRMCIGRRIAELELNLALAKISQTFKLEYLGEGTVAPTVQGLLVPGGPVKVGFTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDM8</accession>
    <name>A0A913ZDM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049055.1">
        <property type="nucleotide sequence ID" value="XM_038193127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193127.1">
        <property type="protein sequence ID" value="XP_038049055.1"/>
        <property type="gene ID" value="LOC119722791"/>
    </dbReference>
    <dbReference type="GeneID" id="119722791"/>
    <dbReference type="CTD" id="10576"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10259763at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="524" mass="56875" checksum="76A13170DB8702CE" modified="2023-02-22" version="1">MLAPVQILKQNAEEEKAETARLSSFVGAIAIGDLVKSTLGPKGMDKILQSPNKNSPLIVTNDGATILKSIGIDNPACKILVEISKVQDDEVGDGTTSVTVLACELLREAETLVGQKLHPQTIIAGWRKAVEAADKALAQAAMDNSADIEKFRKDLFNIAMTTLSSKIVQQGREMFANLAVDAVLRLKGKTDLQAIQIIKKLGGNMSDSYLESGFLLDKKIGINQPKRIDKARILIANTTMDTDKIKVFGSRVRVDGMAKVAELELAEKEKMKEKVQKIVKHDINVFINRQLIYNYPEQLFADNGIMAIEHADFDGIERLALVTGGEIVSTFDHPELVKLGHCDVIEEIMIGEDKLIRFSGVALGEACTVVLRGATQQILDEVERSLHDALCVLSQTTRTYKTVLGGGCSEMLMANAVQQLAAQTPGKEAVAIEAFARALAKLPTIIADNGGYDSSQLVAQLRALHNQGKNTVGLNMKEGTVGDMIELGVIESYQLKKQVLHSAAEAAEMILRVDDIIKAAPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZDQ4</accession>
    <name>A0A913ZDQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049907.1">
        <property type="nucleotide sequence ID" value="XM_038193979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZDQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193979.1">
        <property type="protein sequence ID" value="XP_038049907.1"/>
        <property type="gene ID" value="LOC119723373"/>
    </dbReference>
    <dbReference type="GeneID" id="119723373"/>
    <dbReference type="OMA" id="LPLIWCH"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27666" checksum="13573E2990691DE0" modified="2023-02-22" version="1">MAIPPAKAVPKDAEIMAAILKDMGVTEYEPRLVNQMLEFTYRYVTDVLEDAQAYSNHAGRTEIDSDDVKLAIQGRLDHSFTTPPPREFLMEIARQKNNNPLPAIKPHNGPRLPPDRYCLSASNYRLRPLQKRATLTMPSRLSLSSGISMSSSAGSKLSPSFTLGAKQPYNMTVRTPSSSKPSSAPISIIKGVSRPITTPTINMQSSSTATRAPSMSTSSAVHTVIKTEVTSPPPSQSSVIHTTKRKREDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF11</accession>
    <name>A0A913ZF11_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049651.1">
        <property type="nucleotide sequence ID" value="XM_038193723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193723.1">
        <property type="protein sequence ID" value="XP_038049651.1"/>
        <property type="gene ID" value="LOC119723164"/>
    </dbReference>
    <dbReference type="GeneID" id="119723164"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037725270" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="145" mass="16120" checksum="6F44B36F26D716BB" modified="2023-02-22" version="1">MFRPVAICAALCLVAAVGVAFADETDDLKLRALLTDFLENSKRGSDGCMKNLDNGPMAFNWVVQDADKSKFGNIGLWLFKIDGSDQVNFGITIDKYEELIRKTRQWTPQKGAHEKKIDFETDDAYLTMTINFMDGTPVSACLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF64</accession>
    <name>A0A913ZF64_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049696.1">
        <property type="nucleotide sequence ID" value="XM_038193768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF64"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193768.1">
        <property type="protein sequence ID" value="XP_038049696.1"/>
        <property type="gene ID" value="LOC119723207"/>
    </dbReference>
    <dbReference type="GeneID" id="119723207"/>
    <dbReference type="OMA" id="SSCRYTE"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF9">
        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="206" mass="22954" checksum="97B072C552F8199A" modified="2023-02-22" version="1">MDQSRSSCRYTEMQPMSYYDNYPATNGDMANYNTLSHSMYVNNSYHEGIHNGAASPLRGGGGHCYPTPDGSNSSDSCREEDIEHVLAPGYPGGGERRCLLWACKACKRKNVAVDKRKAATMRERRRLRKVNEAFEALKRHTSANPNQRLPKVEILRNAIEYIEKLERLLQVEKGNGDGSEMETAETSSNASDVMVSLRVTLTGCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFG9</accession>
    <name>A0A913ZFG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049793.1">
        <property type="nucleotide sequence ID" value="XM_038193865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049794.1">
        <property type="nucleotide sequence ID" value="XM_038193866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049795.1">
        <property type="nucleotide sequence ID" value="XM_038193867.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049796.1">
        <property type="nucleotide sequence ID" value="XM_038193868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193865.1">
        <property type="protein sequence ID" value="XP_038049793.1"/>
        <property type="gene ID" value="LOC119723313"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193866.1">
        <property type="protein sequence ID" value="XP_038049794.1"/>
        <property type="gene ID" value="LOC119723313"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193867.1">
        <property type="protein sequence ID" value="XP_038049795.1"/>
        <property type="gene ID" value="LOC119723313"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193868.1">
        <property type="protein sequence ID" value="XP_038049796.1"/>
        <property type="gene ID" value="LOC119723313"/>
    </dbReference>
    <dbReference type="GeneID" id="119723313"/>
    <dbReference type="OMA" id="CPRINAN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF42">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="484"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="541" mass="59252" checksum="C210D39E5740E829" modified="2023-02-22" version="1">MDFTEAYSDRCSTVGAAVHTGNVNVLRELIGRGASVNIHDNRGWTPLHEAANAKKYECLRILLTKLTKEDVNARTWEGETAVFLAARAGCLETLMLLIKDGADPNISNHEGGSPILQAVSGNHKDCVAFLLKKGADVQSHLYGGWSLLHEAACCGFSDILQLLLKAGATIAVKDDFGIMPVFTAAQYGKLDCLRLLIENGADPNARAEDDATPLYLAAQEGYPHCVEYLLNHGAKVDIPTKTAEGFRPIHVAAYRGHIECLKLLLPPSFSVLEQGKFPGEWEGLLTPLQLAAKGGHNQVIRILLEAGCDPDCGVRNPSAETKETLLQMAQMLEIDPPPFHCATLSGHYSTAELLLDSGACICLSSSSFCLLTMFRDDSKALEMLLDHGGQVDCKHIISDLFRKLFPLHILGILINRGLRLCFNCRAQHSLCPNINSAVSGLRDSTVIKLIKLIFHYVDRLSLCEHSTKHLQELGCYYKVISLTSNPHSLLHLCRVAITEHMGTTCAPKIIPNIDFLPVLIKDFLLYREILPGTDCTVLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFQ8</accession>
    <name>A0A913ZFQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell division cycle protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050279.1">
        <property type="nucleotide sequence ID" value="XM_038194351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194351.1">
        <property type="protein sequence ID" value="XP_038050279.1"/>
        <property type="gene ID" value="LOC119723611"/>
    </dbReference>
    <dbReference type="GeneID" id="119723611"/>
    <dbReference type="CTD" id="8881"/>
    <dbReference type="OMA" id="DPFHNNA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="66266" checksum="4E0F2ABDB6F2EE49" modified="2023-02-22" version="1">MSKMNDRKSSEGLEVCKLQSLVRLYIDKHQYESAHFWADKLVSLSDDEIADIYWLAQTLYLTGQYHRAAHLLQSKKLNKANKACQYLTAKCHAAVKEWEEALNVLDASESSIKTPGKVKEEDLTSPGVDIQDIPLQNVESSICLLRGQVYEAMENRVLAAENYRLALQQDPYCFEAFELLVKHQMLTANEERTLLDSLPLTKNCRLAEMEVVKSVYETILKKYDKPSLSSLPSCLEPLKDNSDVVTCLAERHYYNCDFRTCHKITSEVLNKDPYHGTCLPLHIATLVELRKSNDLFYLAHKLVDLYPGKPISWFAVGCYYYLVGKNDSARRFFSKATTLDRLYGPAWLAFGHSFAAEGEHDQAMAAYFTASQLMKGCHLPLLFVGLEYGLTKNFKLAEKFFDQALAIAPSDPFVLHEMGVVEFHNGDWDEAEKYFVKALAIVQSMGTQDVPEKWEPLLNNLGHVSRKLKKYEEALEFHRQALVLCPHSPSSYSAIGYVYSLMGDFAMAIDYFHKALGLGRRYVFSETMLARVIEQFILETSPSDGGSVDISELTSPAAPKDDVMILMKDDTSSSLDIEVEMEDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGJ4</accession>
    <name>A0A913ZGJ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050903.1">
        <property type="nucleotide sequence ID" value="XM_038194975.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194975.1">
        <property type="protein sequence ID" value="XP_038050903.1"/>
        <property type="gene ID" value="LOC119724056"/>
    </dbReference>
    <dbReference type="GeneID" id="119724056"/>
    <dbReference type="OMA" id="EMEMPEV"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038032142" description="F5/8 type C domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="185"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="516"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1260"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1384"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1419"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1447"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1624"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1665"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1706"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1750"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1791"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1879"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1920"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1964"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2005"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2046"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2087"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2120"/>
            <end position="2130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2142" mass="230960" checksum="82F81A9CC5FE8D0D" modified="2023-02-22" version="1">MMSPLGVACLPLLMLSAISYNGALSQPLARNNGAMQDDFSQYADRWTLRRSGCTCQFDFTRRDCACCIVGGAQCPIGAHNLCVKCGQEYTCGIPHPVIKDRVVNGWTGAMECPCPGNPSKEACACCINGGCPCANDPYRCTECGTTAGCGDGKNNPAGPPYVLNKDFERSREGYGIHVHRDPALPNPVPLGVGSGRIPDGQMSASSYIDDHMGPHRARLNALPSDAGAGGWSPLELNRDQYLQIDLVNPTIITGVATQGRAGNSDEWVTSYNLAHSSDGSNWNYYGGDREGKRNGRGMMFKGNSDCDEIVHHNLEDPINARYVRFLPQDYYNRIGMRVELYGQEPEVPTSSGGGIQNLALYKPAEQSSTFEPIFGASGAVDGKDDEGIVITKVQTQPWWYVDLQDHYQIYFVAINNPGIMLCAEPKILTNFVVRVGDNPDVNNNPPCTAIYRRKVEPGESVQIQCQSIDGIPPVGRYVSIELNPDNPNELTHLQVSEVKVYGVATPVPGPTCRIKEGAHYLGMESGEINGAQIDASNYLKGYQPQNARLNLPNRAWVAECRPHTPSLAKEKQYYLKIDLLALTDMEGLLTQGSLVPEESYVSQFMMETSVDGEVFVPYKAADGTVKLFQSNMDGVDIVCHLLPSQICVRAIKIIPISWHRCVAMRVELLGYRVQHVEPVEVLPATQPLVEDEPADEGVDMGTVQPATPIEQEPTVKEAAPAVTTAESEPEMELPEVQTTVLVPVLGSKLATLKPVQADVGVSVGKPSAAVPIPTLAPKAAPVETTLKMEAETEIEMPEVQTTVLIPVVDTKPATPEPVEADVGVTAGKPSADVPIPTLAPKAAPVETTVKIEAETEMEMPEVQTTVLVPVVDTKPATPEPVEADVGVTAGKPSADVPIPTLAPKAAPVETTVKNEAETEMEMPEVQTTVLVPVVDTKPATPEPVEADVGVTAGKPSADVPIPTLAPKAAPVETTVKIEAETEMEMPEVQTTVLVPVVDTKPATPEPVEADVGVTAGKPSADVPIPTLAPKAAPVETTVKIEAETEMEMPEVQTTVLVPVVDTKPATPEPVEADVGVTAGKPSADVPIPTLAPKAAPVETTVKIEAETEMPADQTTAELAEVVASTTPVGNIDDIGKPAADETQNTPPEIGKDLPKNKGKDRPKNKGKDRPTNKGKDRPKNKGKDRPKKKGKKGSDEEEPSVDIGEPAADEQQNKPPKRGKDKGKDRPKKKGKKGSDEEEPSVDIGEPAADEQQNKPPNSGKDKGKDRPKNKGKDRPKNKGKDRPKNKGKDRPKKKGKEGSDEEEPSADISEPAADEQQNKPPKRGKDKGKDRPKNKGKDRSKKKGKKGSDEEEPSVDIGEPAADEQQNKPPKRGKDKGKDRPKNKGKGKPQKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKRKKKGKKGSDEEEPSADEGKPAADEQQNKPPKRGKDKGKKKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDRPKKKGKKGSDEEEPSVDIGEPAADEQQNKPPKGGKDKGKDRPKKKGKKGSDEEEPSVDMGEPAADEQKTKPPKRGKDKGKDRPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGKEGSDEEEPSADIGEPAADEQQNKSPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDEPKKKGKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPLADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGEPAADEQQNKPPKRGKDKGKDKPKKKGKKGSDEEEPSADIGARIRARINLRRKERRDLMKRNLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH27</accession>
    <name>A0A913ZH27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051093.1">
        <property type="nucleotide sequence ID" value="XM_038195165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195165.1">
        <property type="protein sequence ID" value="XP_038051093.1"/>
        <property type="gene ID" value="LOC119724216"/>
    </dbReference>
    <dbReference type="GeneID" id="119724216"/>
    <dbReference type="OMA" id="YSAINMT"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002395">
        <property type="entry name" value="Enhancer binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="784" mass="88246" checksum="B4A13BD09EF1546C" modified="2023-02-22" version="1">MSVKGHDTVSLGDTNMPDGEDMETSAEAEHLNNAVADTGQEVTRKRRTGGMNEAQETVEQHSPPVDTDDSLKKIEDASLSDRSTAVPLSLTVTKESLGLQDSADSLVADAGSSVPHSTRIEIRLKEDSTDSHGTEMHPTPEVDVPDTRVLNLEVSCSSDDKAPEGDKANVYAVLYSCNKCSFCTSKLSELKLHAQTERHENETGKEGESSSKDSGEAMRIQYACTDCSFKSERFHTYREHLLTHAKIGEKEMFKCMDCDYSTRHKYNLKTHLKRHAKIGELCEDELFRCPKCDYVSPYKHDLMTHTKKHEAEKPFRCSQCDFQSIYKHSLIHHVRSKHERLRPFKCDQCDYSSARKQDLQTHMGRHAEEKRFKCDRCTYATPYRVSFKAHMDRHMGNKLFKCDQEGCDFATTTKQNLKSHELRHSTVKPLQCTFCDYTAAHKQQMVNHEQKHGVTDRPSSTYSCLSCDYTTAHRYSLQRHMNRHKADRKMPEKDYVCEECGYSTGYKNSLKRHMAKHSDVKPFKCGHCNYSAINMTQMHVHIAKHTGIKPFKCDVCDYATANKQHLVGHMAKHSTVRLNCPKCSFSTAWKQRLRAHLKAHEMGQLFQKKVTTSTGIQTSKILYTLPGSSQDQGDEATMIAERNNALNEISNAIEAFHSYSLQVEVASNQDQHQGNGNTSSGGQGEGSSSQEADEKSKSQRSVEQVHLVDEDGNRVAAALQCVNGEQSIEVALKDLQKDGSQIFVWKQTEEAADSQQISTASPQQSSVESESDVSLLVIDEMKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZI21</accession>
    <name>A0A913ZI21_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051432.1">
        <property type="nucleotide sequence ID" value="XM_038195504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZI21"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195504.1">
        <property type="protein sequence ID" value="XP_038051432.1"/>
        <property type="gene ID" value="LOC119724443"/>
    </dbReference>
    <dbReference type="GeneID" id="119724443"/>
    <dbReference type="OrthoDB" id="5810838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="77"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="382" mass="42441" checksum="190F7AE2027DB2F5" modified="2023-02-22" version="1">MSFLTHFRESVSINQEDIVDLNGGGFFIDLPPVCPIPNTTTIDLSDPSIAVRYEYNSVHTVLVTIVYPCICLFGILTNSIFLLTVFRVPDMRTITNAYLSNLAVSDIMFLSTGAGFGLWKYLSTPVTADYSICGGAAGCFFTTLLNNTPFHASTFLVTVVTVERYLAVCRPILHRNINSRGHTIGLLAITWLVAACLAVFVFFGGSNYIVKCVMWPDDIRYSNFPQTIASCYNSALWAYVFVAFALTAPTFLAFLVTFTLDVFIVRKLSRRINKFGSEQPSSLAQSRRIRDRVAKMLVITGALFFTLITPRFILSIYFFVTFFAGAPGLSPDAEFIVFVTTNALLYVNSAINPIIYAFSNGRYRHAARLALCSRSVIYAVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZK54</accession>
    <name>A0A913ZK54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-glutamyltranspeptidase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051709.1">
        <property type="nucleotide sequence ID" value="XM_038195781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZK54"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195781.1">
        <property type="protein sequence ID" value="XP_038051709.1"/>
        <property type="gene ID" value="LOC119724642"/>
    </dbReference>
    <dbReference type="GeneID" id="119724642"/>
    <dbReference type="CTD" id="2686"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF54">
        <property type="entry name" value="GLUTATHIONE HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="447"/>
            <end position="449"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67163" checksum="DB75C45AAB99E025" modified="2023-02-22" version="1">MDSRQYELLPMNGAKVEESDMEEFVSDKASLIDPAAKPTRTENAPLRTQQSIGHETIFGFEGLHVIIVMAVVVSLAITAAMVITILVGEPQVPPHGAVATGNQVCSDAGVSILQQGGSAVDAAIAAMLCIGVVNAQSSGIGGGGFMLILDAEAAAYTGIDFRETAPANARLNMFADNPGASLYSGLAVGIPGELHGMRQAWEKYGKLRWKQLFDPAIDFARNGFEVTANLGKELETVPLALMSDDLRAVYAPTGVRVREGDMVFRENFAQLLDNIAENGIQELYTGYVAQEIVDMVNNNGGNMTLADLQGYKPVEMQPIQVNYRDYNLVTLPQPSGGPMFLTLMNIMELFNVTAANKDTSLYYHRFIEAMKFVKAEEIGLGESAIANYSQNMISKRNAKLLRANITDDTTHPPDYYFSFAQGILRTKGTSQISVIDSDNNMVSVTTSVNMAFGSLLMTPSGVVLNNQMDDFDWPGKSLTYNSSKSNYIAPGKRPQSHMSPVMGRNTTTACSRRFATGGEGGKYITAAVANVVMELLGFQSSLVNASAPLKRVFATLIPDKVIVEEDVSDKIVADLQAKGHNVEVWTSEKGLFNAVQSVMKENDIMYAVSDPRREGGGASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL26</accession>
    <name>A0A913ZL26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052029.1">
        <property type="nucleotide sequence ID" value="XM_038196101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196101.1">
        <property type="protein sequence ID" value="XP_038052029.1"/>
        <property type="gene ID" value="LOC119724840"/>
    </dbReference>
    <dbReference type="GeneID" id="119724840"/>
    <dbReference type="OMA" id="EYFWRPS"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000078">
        <property type="entry name" value="Chromate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="22136" checksum="013506E71B392FBC" modified="2023-02-22" version="1">MANKLKIVLFLGTCRENRLGERVAKFMINQLKKDGKHDVEFMDAEEFNLPILKKALFFYKDETQAPQILQDAKKKIIEADGYVFVSGEYNHSIPPGLANMVDHFPTSIFTYKPSAIVCYSPGIYGGMRAAMQLRCFLGEIGCLPVSNIFGIPKCHQAISAEGEAIDDHMEKGAAKIIEQLDWNATAMRNHRQAVGVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMN2</accession>
    <name>A0A913ZMN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052350.1">
        <property type="nucleotide sequence ID" value="XM_038196422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196422.1">
        <property type="protein sequence ID" value="XP_038052350.1"/>
        <property type="gene ID" value="LOC119725059"/>
    </dbReference>
    <dbReference type="GeneID" id="119725059"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="335" mass="38224" checksum="8100A9D766D30D99" modified="2023-02-22" version="1">MNATEEHNEEIAGVKRVCQIMAAEGVIGVLGNLLVCYVILRVKFLHNMTNYLLVNLAVADMLLCLEETLYYLTSDCKLIAFAPVSNGVRDLFCRILASRFLAWALTYTSAYNLCVVTLERYIAIVHPLHYARKLTTGRMVTLITLVWVISFLISLPLLFTIETSSYPDRICLIKYPHLLFPIIFSIYSFLLGYLLPLTLMIVAYYKMQVTLKRQAKALNLQHARAAAYDLVIARQNLVSMLKTVLGALILLWTLDYVTILLCLQHTEEAQFLFCGSKGYHYTTLFASLLFTFNSVINPIIYEFKYKKFRQGLKVAFCSCFKRQGGNRVDVEMVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSM8</accession>
    <name>A0A913ZSM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038054414.1">
        <property type="nucleotide sequence ID" value="XM_038198486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198486.1">
        <property type="protein sequence ID" value="XP_038054414.1"/>
        <property type="gene ID" value="LOC119726692"/>
    </dbReference>
    <dbReference type="GeneID" id="119726692"/>
    <dbReference type="OMA" id="PYSHINS"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01816">
        <property type="entry name" value="RBD_RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14062">
        <property type="entry name" value="STKc_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000004">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000036">
        <property type="entry name" value="RAF proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF262">
        <property type="entry name" value="RAF HOMOLOG SERINE_THREONINE-PROTEIN KINASE RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="14">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="496"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="808" mass="90567" checksum="FF83E3BA687B9951" modified="2023-02-22" version="1">MKTVIFRQMKTSKMALDGQHEGFPSPDSLTIDNGHDGLETLVPGYSMEELNHVQHFIELTKKNIQELLAKFPSGPNPPSIFVEEYEELTEKLNELQVRKQELQDCMSNGRQSPSPVPSPYTPEPGPHYPHSLKTLTATDGPFAHGPYRPLEGAVRTHVGDDAYVAKEIPTSPPVSKYVRASLPNKQRTSVLCKPGTTLRDALAKAMKVRELTVEMCNVYKRQPRHPVAWDTDMMYLAGEEVCVEVSEQYPTARSISHNFVRKTFFTLMFCDNCHKLLFHGFRCQTCGYKFHQRCASKVPTLCVAENLYKMLLMKNVDEDEDPYGEEPESPSTPITTDPPKATLPRERSTSAPNVSFNAVNAISNEAFSDSKFVFKQNPADLGARHTHAVSPAVSVARPRQISFTPTILSAGRDTVFDYSPTSALPAMASLASSLPNSVVHSPNKIVSNNQASPTHRDRWKNRGPPSSTSSAEDTKIRKPRQRRDSNDDWEIPTDEILMGPRIGSGSFGTVFKGHWHGPVAVKRLNVTDPTASQLQAFKNEVAVLRKTRHANILLFMGCTSKPQLSIVTQWCEGSSLYKHLHVQETKFEMYNLINIARQTAQGMDYLHAKNIIHRDMKSNNIFLHDDLTVKIGDFGLATVKSRWSGSQLCEQPTGSILWMAPEVIRMRDPNPYSFQSDVYAFGVVLFELVSGQLPYSNINNKDQIIWMVGRGYLSPEPSKARNDTPKALKRLIVDCCKMNRDERPLFPQILASLEGLARLLPKVHRSHSEPSMNRARFQTDDFMYCPSPKTPINSQFGAFPFFTGTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSV4</accession>
    <name>A0A913ZSV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054269.1">
        <property type="nucleotide sequence ID" value="XM_038198341.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038054270.1">
        <property type="nucleotide sequence ID" value="XM_038198342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198341.1">
        <property type="protein sequence ID" value="XP_038054269.1"/>
        <property type="gene ID" value="LOC119726601"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198342.1">
        <property type="protein sequence ID" value="XP_038054270.1"/>
        <property type="gene ID" value="LOC119726601"/>
    </dbReference>
    <dbReference type="GeneID" id="119726601"/>
    <dbReference type="CTD" id="23151"/>
    <dbReference type="OMA" id="WHPVEVT"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034164">
        <property type="term" value="P:negative regulation of toll-like receptor 9 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM" evidence="3">
        <location>
            <begin position="498"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="645" mass="73129" checksum="C970FF0AE25D9E4C" modified="2023-02-22" version="1">MSLRAHLRSRFHKQTPPTEGALQKRSSNTSDIQASSGSDDVNSSADELSLSDHVMEGGSPSSGRKKYDKGGASGDSSSPGTRRKEQGRLSNEESRKRSGSTTSQRSQWEDSEKNIYETQLRTLQEQLVDSMIQNQTLQSEVTKFRENSDMTKLLQMLDHEKDNSAKLSQECEELQQQLENIERRSYSMEERPSSVDTAEEADSVDLAPSETEPQPPRKPTLKTQMQEWLMNTVYEVIADFTEDPDDEKTTENDEGEELAVKKLKANIKRFKAGYQPIIQWLKAVGNLFGWKSAPASFLAFIIYMYAVAKGWLISLMLGLALWHLTKTYLISKGFVIKFSLLPYCEEEENSDMDKQLGLSDKFQLVLLVARRVQNYMGLLADGLEKIQNLVMWGNPEATQKLYTGLLCAFIASVVLPGEWFFICGGIYLGVKVFITGNIFSRFPRVKAKYDSSYIMWQSLPTHAQKQRRNTLERRRKYIIPAVVTERTPADEGQGNFLEMFSLPSEELPLPGWQTGKRCTQIVRDKSVSFKNGRIYLTRSFLCFERSRLKNRVDKHIVIPLADIVTIEKAKPFFLMPGSGMSIEIRVVSEEKPYIFGAILNRDEVHAVILRQVCSVRDVRLKDKTKHKETSVKDGRAAGTSASSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTV7</accession>
    <name>A0A913ZTV7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BMP and activin membrane-bound inhibitor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044389.1">
        <property type="nucleotide sequence ID" value="XM_038188461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055032.1">
        <property type="nucleotide sequence ID" value="XM_038199104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188461.1">
        <property type="protein sequence ID" value="XP_038044389.1"/>
        <property type="gene ID" value="LOC119719139"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199104.1">
        <property type="protein sequence ID" value="XP_038055032.1"/>
        <property type="gene ID" value="LOC119727240"/>
    </dbReference>
    <dbReference type="GeneID" id="119719139"/>
    <dbReference type="GeneID" id="119727240"/>
    <dbReference type="OMA" id="QLICACT"/>
    <dbReference type="OrthoDB" id="6412674at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045807">
        <property type="entry name" value="BAMBI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06211">
        <property type="entry name" value="BAMBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275641" description="BMP and activin membrane-bound inhibitor N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="BMP and activin membrane-bound inhibitor N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="229" mass="25565" checksum="D2DA4E17373ECB61" modified="2023-02-22" version="1">MNLVQMCILGLYVMVITLVQMKTHITHGQLTCACTTPACNDTGSVTCSAVTSCYTQYLDRRDGSSPITRGCIDEKTPLLCENRRPFVHVTPWPHLQCCKESMCNADTVIITPPMWPRKASQSTTAQVFLRDSHPHENSKLPAHDSEQYTDDNFQHPVMVIVLPVVALCLFVILLIVVIVVVRQSRTHHRTGESGANIHAAGLPDSHCRGKFYNTGDPYIREKFFNSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUE0</accession>
    <name>A0A913ZUE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054855.1">
        <property type="nucleotide sequence ID" value="XM_038198927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZUE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198927.1">
        <property type="protein sequence ID" value="XP_038054855.1"/>
        <property type="gene ID" value="LOC119727037"/>
    </dbReference>
    <dbReference type="GeneID" id="119727037"/>
    <dbReference type="CTD" id="6147"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="178" mass="19992" checksum="2B38241AC19B29DB" modified="2023-02-22" version="1">MGPKARKEALRKTGKKGPAQAEPAAKVEARAKQEAKSKAKAEALKAKKAALRGNISTRKRKVRKQVTFRRPKTLKTPRKPKYPRKSVPSRPKLDQFTIIKYPLTTESAMKKIEENNTLVFITALKANKFQIKTAVKKLYDIDVAKVNTLIRPDGQKKAYVRLAPDYDALDIANKIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUW1</accession>
    <name>A0A913ZUW1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054856.1">
        <property type="nucleotide sequence ID" value="XM_038198928.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038198928.1">
        <property type="protein sequence ID" value="XP_038054856.1"/>
        <property type="gene ID" value="LOC119727038"/>
    </dbReference>
    <dbReference type="GeneID" id="119727038"/>
    <dbReference type="OMA" id="KLWMEAR"/>
    <dbReference type="OrthoDB" id="421838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000282">
        <property type="entry name" value="Strawberry notch homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="7">
        <location>
            <begin position="295"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="6">
        <location>
            <begin position="931"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1448" mass="160953" checksum="1A556F96ED78A731" modified="2023-02-22" version="1">MNGLANDGQDLLLAALSESGLAFDEFPGATDANDQNDFDLSLLGPPDPFGANVPPSQYMAGLQSNETDPLLAMLQGEHQQQQQQQQQQRMQQQQQQLQQPPTFVSTPSVHQMPDMESAIPKLTHSSGTNSGTVYVMDKNRSWKPVVSNTPSPIPPIDSKSDFFQTIATPAKNPPPLMPTLGGFGKSGSMLSRIKTAPAGLSDLLNTVPSTSNMPLGFPGRRADKPLGSNAAAINKGLTQKDVSRLWSNDDIKLESVTPKVQKPAEEDIDDEEEENMGHAETYANYMPSKLRIGLPHPDPVVETSSMASVQPPNIYYRLSIPEEVIDRRQLSALQLESITYACQQHETMLLSGERAGYLIGDGAGVGKGRTIAGIIHENYLLGRKRSIWFSVSNDLKFDAMRDLKDISANIPVHSLNKFKYVKINSQANGYVRKGIIFSTYSSLIGESQATHKYDTRLKQLLRWCGKDFDGVIIFDECHKAKNLVPVGSAKPTKTGLTVLELQKQLPKARVVYCSATGASEPRNMAYMSRLGIWGKGTPFPDFNAFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFQGVTFNINEVKLSVEFKKIYNKAVGLWLAARERFIKAADLIGAEQRMRKSMWGQFWSAHQRFFKYLCIAAKVQHAVKLAKEAVKIGKCVVIGLQSTGEARTLDALEEAGGELNDFVSTAKSVFSTLIEKHFPAPNRKKTASMFNLNSNSGASSPAWSESSRGVKRKRDKLTNGLKSKQPKHWWEEDSRENSPLNGNSNSNSNNTGGESDDSDVILLSSSDSDSDSDDDDVSSKGSSNDEDDFNPFRDNSDDDPWVTRKSKVKEEKTKKKKKKKKAEDKNLPMMRNLEGKMNSALYAAGILTKPRLPNTLATMSSIPAATNSMLLPGMDAYERAILMKQELLDMCEEIGSVLPNNTLDELIDELGGPENVAEMTGRKGRVVSNDDGYVRYESRSEYDIPLEILNLTEKKRFMDGDKQVAIISEAASSGISLQADKRVPNQRRRVHITLELPWSADRAIQQFGRTHRSNQVHAPEYIFLISELAGERRFASIVAKRLESMGALTHGDRRATETRDLSIFNIDNKYGRAALESVMKSVVDLQSSLVPPPADYHGHFLRDAREALIGVGMVAYDERYHVPVLDKDFNNMSKFLNRILGMEVEMQNQLFAYFTATLEAIVQQAKRDGKYDMGILDIGSMDQGQKVRKLQTQTFVRTFSTGTVHTELHKVSQERGLSWDSALDMWSALTKPEEGFYVTSQPTNNKRTAVLVKYGTTSNAIKKHLVNVFKPNIGMQGKMESLADVRKKYRKVTMPDEAQGAWEAQYSAAEILCSHAYWRDSCKRVLAGLPCEIGLRRRNFYILSGSVLSVWDRVEKILVLQPGPASKMQILRLKTDDGSKIVGIMIPSNCVQAVRSSLLEGATTYVDNFEDNEIITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW89</accession>
    <name>A0A913ZW89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055787.1">
        <property type="nucleotide sequence ID" value="XM_038199859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199859.1">
        <property type="protein sequence ID" value="XP_038055787.1"/>
        <property type="gene ID" value="LOC119727794"/>
    </dbReference>
    <dbReference type="GeneID" id="119727794"/>
    <dbReference type="OMA" id="PMEAGHT"/>
    <dbReference type="OrthoDB" id="10033306at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="237"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="365" mass="41726" checksum="8906DECE2E6C99AB" modified="2023-02-22" version="1">MEDSPVELELDPPTSQRAAPHKITSGGRKFNTRALTVKDIERVVQFISSYAEEHALVIPGRVSGVKCQDPRVRLLPSSETKSSVWRKYQTYMGDMNSTRRLSGDPDFCIVKQVTFTKLWSQYCPFVLTTRPKTDLCWVCQRNNSLVYQSANQLDGEKLAQLRRQEEHLRVVNMERDLYRSMVADCKQAVGEEHLGLHQPASRRGTAHYSFDFAQQVHYPHNPNQPGPMYFLCPRKCGIFGVCCEGIPEQVNYLVDEGMSSSKGSNAVLSYLHHFFLHYGLGEENVELHCDNCSGQNKNNFVMWYFVWRTLHGFHDNVAVNFLIAGHTKFSPDWCFGLLKQRYRKCVVSCLGDLEEVVRTSTRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX08</accession>
    <name>A0A913ZX08_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056193.1">
        <property type="nucleotide sequence ID" value="XM_038200265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX08"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200265.1">
        <property type="protein sequence ID" value="XP_038056193.1"/>
        <property type="gene ID" value="LOC119728177"/>
    </dbReference>
    <dbReference type="GeneID" id="119728177"/>
    <dbReference type="OMA" id="DITCEWM"/>
    <dbReference type="OrthoDB" id="9934532at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF35">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037526144" evidence="10">
        <location>
            <begin position="34"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="235"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="349"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="761" mass="83051" checksum="6D48FFD19C44222B" modified="2023-02-22" version="1">MLCLKDRSHSTHLCFTCWLHFIIVLCLTVSARGLNMAQAQGTVEIFPVEPTILAGTDFNLTCTIGQSSSVLAQDIKWKRGGETLPAELYSALDDKTSQLQVRKAEFQDSGLYACVSEKSTLDGGNETQVYVGEPPDAAHGLFCYCPNLWDVTCKWELGKDTNLNTTYMLQYRYYHIHEGSDFEEGSCSCSDEQTCTMSGSIHGPIQLRVLSSNKLGHAISTELAFDYESETVPHPPRNVSANPIPRSRLNVTWELPLEWKTSYRDYLYYKLEYYKEGTNVWMEYPGPSDEFINGKTYAELPSPSSLDAYTVYCVRVAAKIKYGSWSQWSDLSCSRTLEQRPDAEVNVTWSSQVNAQNDSLRDVLLKWVPLSQANARGKILGYRVIRGNRSHENVTTVDDPSTTSLEIPGLERYRGYRFAIEAYNGAGPSPRSLLDIAAEQKPAPSFIVTIIVAIVVVAVTFVVIAVIWCLVKHYHLLKPVPSISMIPLERFDRVISRPGQRGAVEREVFDEPRGHRTPNGVLPNGNIPGGSHPPAGGAAANAAEDSERDYVQLREQASPDESFPLLRSNSGNGSCSGKSNSCRKMSQGSVNSTNSSGVCSDKDPESPGSTVANYGKFAKLYVQIPDSALSDSQHSGPGQPRLDSTDSGFGDNGSEYRMPSYTKLSTIPSDPGSVETSPGWETDPEGDYNGGDVYHRIAEGEPVASNQDLLLGQPTVPAYTRLSSIPAPVINPTAPSVGNEVHVTISDGTAPSFGNSGAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYD2</accession>
    <name>A0A913ZYD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056572.1">
        <property type="nucleotide sequence ID" value="XM_038200644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200644.1">
        <property type="protein sequence ID" value="XP_038056572.1"/>
        <property type="gene ID" value="LOC119728414"/>
    </dbReference>
    <dbReference type="GeneID" id="119728414"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036941786" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29465" checksum="B2AE1E157809B98E" modified="2023-02-22" version="1">MYSLKCFAVLAITYVITVLGSHICPSEPAVKCSCPPQWQLWRNGCYRLTSSENNWEGAETGCKDIGGTMAAPRSVEEINFMAKMARSEYSLYEAWIACNDKEDEGTWECDGQKGDEPFLVWDAGQPDNWGDNQDCVLISARYNDRMDDNYCGFQCRAFCVRQADCTHLPTQPRQYCLSTDTHGRILNSTCLLNHTIRELITEGVVACGSACTKESGCRSFNIKKTKEGKKVCQLNNSTSSEDKDKFLKTDYFCMYSQMCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYL9</accession>
    <name>A0A913ZYL9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056166.1">
        <property type="nucleotide sequence ID" value="XM_038200238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200238.1">
        <property type="protein sequence ID" value="XP_038056166.1"/>
        <property type="gene ID" value="LOC119728159"/>
    </dbReference>
    <dbReference type="GeneID" id="119728159"/>
    <dbReference type="OrthoDB" id="6142414at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034609">
        <property type="entry name" value="Syce2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22349" checksum="B82CF7E4FB7D57FF" modified="2023-02-22" version="1">METLQEYSAAAEMDCLSLPQQQTQHAQPVSGEGQGQAEFDPDRADFLEQSIPSESACSNIPLSFTNPTQEFPQTSMLQASAQQMPQTQQMPPMSNSVNREILNQRTQQLIDDINAKRKRDTTLLADFKKAMELQASSSYEGLEQAMFQMYEGNGKAIQEKLQELFATLDRISTLEMELEQFKTSLGALYSEIQGPAARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYQ2</accession>
    <name>A0A913ZYQ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056763.1">
        <property type="nucleotide sequence ID" value="XM_038200835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200835.1">
        <property type="protein sequence ID" value="XP_038056763.1"/>
        <property type="gene ID" value="LOC119728552"/>
    </dbReference>
    <dbReference type="GeneID" id="119728552"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="313"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="38590" checksum="4373F2084F1A57D2" modified="2023-02-22" version="1">MVYRVGVVGAGVIGLSTAYNIKDRIPDAEVTIVADRFSPNTTGDGTGGLWMPYMLGSTPTESVMKWGKRTWDHLIKILRSPEADAAGVSIHSGHILYEQKPEQDPFWKDMVFHFKHFTQRELDILFPGVKFGVHATMMFCLCLRYLPWLMQRYKAIGGRVMKQRLSSLDEIADLYDVIVACPGVRARHLLDDKEVYPIRGQIVTFTNPRSAMSYLDTENPDGGSDTYLLPSPSAEYIHCGGTAQVNNWNEESDPEDVKGIIERCTKLVPSLKSAKVVSTWAGLRPGRSSIRLEKEDKMIGGKLKKVVYNYGHGGSGITLHWGCSLEATELVRQSIAELQAIGPTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYY8</accession>
    <name>A0A913ZYY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056782.1">
        <property type="nucleotide sequence ID" value="XM_038200854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200854.1">
        <property type="protein sequence ID" value="XP_038056782.1"/>
        <property type="gene ID" value="LOC119728563"/>
    </dbReference>
    <dbReference type="GeneID" id="119728563"/>
    <dbReference type="OMA" id="EYPIILM"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 66 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23650" checksum="48AFB2FF29A1D3BC" modified="2023-02-22" version="1">MAASTEGGLPTSALFVINLLCVVPCVVLKVPQLWSLYASKSARGVSLPSVILELISYTIFAVYMFVHSLPLMQYAEYLFLIVQVWVVILMMLHYMDQVHFSLLPYSALYFIAVWIVGSGLTPNWFVALLLTLSTPISASGMIVQILAIYRIKDSGSVSFSSWFISWATGFLRLITFIVAGDMLVVSSYVVTNSLRAAGCAVIYYYQPSPKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A060</accession>
    <name>A0A914A060_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056975.1">
        <property type="nucleotide sequence ID" value="XM_038201047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A060"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201047.1">
        <property type="protein sequence ID" value="XP_038056975.1"/>
        <property type="gene ID" value="LOC119728709"/>
    </dbReference>
    <dbReference type="GeneID" id="119728709"/>
    <dbReference type="OMA" id="NEICWDK"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="91" mass="10129" checksum="5EA1231D16AE96E6" modified="2023-02-22" version="1">MSFDSSSFGGGADGEDAELKAFLAVEGQKAKFQNQVHMFTDVCWDRCVDKPSNKLDSKTETCLVNCVERFIDSTLAMTNRFQQLINKQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0M4</accession>
    <name>A0A914A0M4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA-processing protein UTP23 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057428.1">
        <property type="nucleotide sequence ID" value="XM_038201500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0M4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201500.1">
        <property type="protein sequence ID" value="XP_038057428.1"/>
        <property type="gene ID" value="LOC119729016"/>
    </dbReference>
    <dbReference type="GeneID" id="119729016"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09866">
        <property type="entry name" value="PIN_Fcf1-Utp23-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="251" mass="29138" checksum="F916AA449F45784C" modified="2023-02-22" version="1">MKIKRYKHARRHLGFYKNVFNFREPHLVLVDGTFTCVALRHQTNIKEQLPKYLDGEVQLLSTRCAITETESLGKELYGAANILRRYKMLDCRHRDVPIAAADCFKALIGQDNGHHYYIATQDPELTEFAHSVPGTPLLYMNMNAIILEKPSPTSLDHADKLTKQKMKPSEHQKETLKRLKGPVDRAGAENRRKRKRAKEPNPLSMKKKKKIKTVEKVREEGERSKKRSRRRRQRSEVVTNVTERSGHSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1G6</accession>
    <name>A0A914A1G6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Meiotic recombination protein SPO11-3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038057479.1">
        <property type="nucleotide sequence ID" value="XM_038201551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201551.1">
        <property type="protein sequence ID" value="XP_038057479.1"/>
        <property type="gene ID" value="LOC119729050"/>
    </dbReference>
    <dbReference type="GeneID" id="119729050"/>
    <dbReference type="CTD" id="23626"/>
    <dbReference type="OMA" id="CNVKWIG"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000387">
        <property type="entry name" value="DNA topoisomerase 6 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase 6 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="15">
        <location>
            <begin position="137"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="16">
        <location>
            <begin position="247"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="424" mass="48298" checksum="86E6CB52CC06057A" modified="2023-02-22" version="1">MTSPHRADDKNKMAASRECSSSKWEKLIELQEILQREEKIKQIKRRCFSDNNCGTGSGTSELSTTRTRNVSREDVLRQLESVIEDILTSISHQQPPLLTYNSRSRWDNIQFTDDVGLEMKGKPALTEVRFDAANSVKKFGITLRVVAMCYTLVQSNTYSTKRDLYYNDTKLFGSQSTLDETMENICCMLNVPRRSLHVLATSKGFIAGDLKFTEVDGNHVDCSTSKTGVLVPVHVQDISNVQSRARFVLVVEKDATFQKLLDDGMLEDMWPCIIITGKGFPDVNTRLMVRKLWTTLQIPILGLVDADPHGLEILCVYKFGSKSMSYESHSLTVPCIRWLGILPSDIDRLQVPRDALIPLSKSDLRKAKELMRRPYYKHLPDWMKEMQVLLDLGRKAEIQCLTAISRDYLTKVYVPSKIKYGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A698</accession>
    <name>A0A914A698_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinase suppressor of Ras 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="RefSeq" id="XP_038058931.1">
        <property type="nucleotide sequence ID" value="XM_038203003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A698"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203003.1">
        <property type="protein sequence ID" value="XP_038058931.1"/>
        <property type="gene ID" value="LOC119730214"/>
    </dbReference>
    <dbReference type="GeneID" id="119730214"/>
    <dbReference type="OMA" id="TWRGPIS"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20812">
        <property type="entry name" value="C1_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14063">
        <property type="entry name" value="PK_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000107">
        <property type="entry name" value="kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025561">
        <property type="entry name" value="KSR_SAM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046861">
        <property type="entry name" value="SAM_KSR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046933">
        <property type="entry name" value="SAM_KSR1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13543">
        <property type="entry name" value="SAM_KSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20406">
        <property type="entry name" value="SAM_KSR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="641"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="104273" checksum="20E46B1034B8C0C9" modified="2023-02-22" version="1">MADEPLVVSKALDNLRAIQSVIDGRITSLDGLRKLGSSDYTQQEIKTVEGKLAQLFGRQLAIKQRVKNNGYPLDNELNQFPNLRHLLHVVDIQGNAREKMLDKLQDLSELLEMTEYDIRAQALHCECEERTVRRLLAACKNLKRAYKAQLYGISSNMKDVSDKEPTDTSSYTSNSPESTSPKQKRTSTSSMGSASSEPPSIRVPPTPPPGGYPCEHYGRNQYTVTPPTTPKQWVKKTAAKGTPPPNKKMITVNLPLPESGLKRSKSTEASLPHRIDIEGGGSLSRIRGSKIPPLLKKQTSGGSCEANLNSSRRHSEDTMDRRNMSPHKGMFNSVSAFDTGKARTPPPVVGMLQKGRTANNGAIWQSKSETCLKTDTLAVPPRSPRAPRSNMVHSIKHRFSRKKFFPPPTCDYCHKIMLHGYKCKDCKYVCHNKCQPLAEKVRSCGLPRGYEQVFKDSYENKYGRSGTPSPLLIRRTAVSEASLPQSGQDHRYPPQVPAFSHGESSSNPSSTNSSTSSSPVPFTASSSSTTPPTPAHPSPSPHMDPCKPQFQFPDVTVNGLLNPNFDSYGDTFHSSINSDRTITVDSHNSNDSHDPFTDSERTLPEKVECIDDVDMADQVLHRKNSHKSNVLSEWDIPPDQLEITELIGTGRFGPVYKGRWHGDVAVKMLDIDMSDEEQLQAFKTEVSQFKKTRHDYVVLFMGTYLKPPKLAIVTSLCRGMTLYTRVHQRGERFGMNKAIVLATQVAQGMGYLHAKGIIHKDLKSKNIFLENGKVVITDFALFSIMRLSRENRRPNVMVIPDGWLCYLAPELITALRVDSSGSSDRELPFSTTSDIYSFGTIWYELLAGCLPFHKELAESIIWRVGKGIKQPLTHLQASKDVKDVLMMCWNYNPEKRPEFTDIIKTLNRLPKKRGGLHRSPSHPLHLSRSAESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6U9</accession>
    <name>A0A914A6U9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059141.1">
        <property type="nucleotide sequence ID" value="XM_038203213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6U9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203213.1">
        <property type="protein sequence ID" value="XP_038059141.1"/>
        <property type="gene ID" value="LOC119730357"/>
    </dbReference>
    <dbReference type="GeneID" id="119730357"/>
    <dbReference type="CTD" id="154197"/>
    <dbReference type="OMA" id="SCDRASC"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="61011" checksum="5204D21F55F24F6C" modified="2023-02-22" version="1">MTNVTRHNFEELLPEILRNIERSDFIAIDTEFTGLHFQSDSHNSLFDTPQDRYSKLRQTASQFTVCQLGLSAFIKSSSQNKYSAHTYNFYLFPKSCATIDARFSCQASSIQFLCQYGFDFNKLFYGGVSYLSMEAEKELRQQVEEQESILTSDVDDHLVTSFTSAISDWLPGAKEGDQISLAKISDDMVSIQMQALLRNCFPDIWTSQVDTGEILITKLNPEKKAALLKEERPWTERLLVKLSGFTRVFRHISELKKPLIGHNFLTDLLFLHSKFYKTLPAKFQDFKRNIHDLLPHLYDTKFLIMEIRRELEEAGLSLTSTSLANVYHAMHTDPSKLGVPHLPEIELADNCARYGKEEFFHEAGFDAYLAGYVFLRMAHYITAKDTSIMHPKLLTFRKYIPALAPHENKSNIIRASVPYVNLAGEDPASRRPKLLYVTSRGPSPLQAKELAAMFNTYTSVDVKMIDRRHALLATSTWGGSKDIMRAFKNDRTIHLANYNVFQHSKPVRYGLWGAIAVMGAVCLWTFFGDQPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6V3</accession>
    <name>A0A914A6V3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038059592.1">
        <property type="nucleotide sequence ID" value="XM_038203664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6V3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203664.1">
        <property type="protein sequence ID" value="XP_038059592.1"/>
        <property type="gene ID" value="LOC119730669"/>
    </dbReference>
    <dbReference type="GeneID" id="119730669"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037701599" description="F5/8 type C domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="109"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="28358" checksum="D2762BB0F22EEF2E" modified="2023-02-22" version="1">MDGAVAWAVMVSALTVIVSCHKVCFIGSEYNPQSGIPPRWFLPYKDPCECTAIRLGGTRISASSYRKWAPFYLDELFLSEDSYEIQTYFSCSRATKVPIGRPKTYSLECSSPEPLGLEDGTITDDRMTASDHNQNWPASKGRLNYNGGWAARSLIDPWIEVDLIEASLIAGVITQGDGDWYVTQYKVAYKNQPSSHFEHVTDGSGNITIFIGNTDGNTPVTNLFYESAVATVMRIEPTKWSTGVGLRLELLGCNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7C2</accession>
    <name>A0A914A7C2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059693.1">
        <property type="nucleotide sequence ID" value="XM_038203765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7C2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203765.1">
        <property type="protein sequence ID" value="XP_038059693.1"/>
        <property type="gene ID" value="LOC119730743"/>
    </dbReference>
    <dbReference type="GeneID" id="119730743"/>
    <dbReference type="CTD" id="201965"/>
    <dbReference type="OMA" id="CGMTYTL"/>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="191" mass="22272" checksum="EFFF72B27E8B6920" modified="2023-02-22" version="1">MACKESQEEEKEVLLSIYDGDECFKQTENAYQYRMGPEGHYKSFLLEIRWGDNYPEELPDINLDAFFNNHLQSAVRSSVVERIKAEAEQWLGSAMTYTLFEWAKENVEDLMSEQTEKTAQVKEDRKNTSESVPASKTKERKEALTKAQKRKLANRTDYKGEMPRGWDWVDIVKHLSKTGYSKHQENTDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7F8</accession>
    <name>A0A914A7F8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059723.1">
        <property type="nucleotide sequence ID" value="XM_038203795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7F8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203795.1">
        <property type="protein sequence ID" value="XP_038059723.1"/>
        <property type="gene ID" value="LOC119730768"/>
    </dbReference>
    <dbReference type="GeneID" id="119730768"/>
    <dbReference type="CTD" id="51174"/>
    <dbReference type="OMA" id="ACHPEYK"/>
    <dbReference type="OrthoDB" id="10250004at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000021">
        <property type="entry name" value="Tubulin delta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="52"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50622" checksum="A5716B515FDB9F32" modified="2023-02-22" version="1">MSVVTVQLGQCGNQVGHQFFQTLMSDLTSQDDKKPCLGYHSESLRRFFHDPQDGIFHRTEGSRAKVPTARAVLVDMEGKVVQNVASQAKKSGLWQYDKKQLVSRKRGAGNNWADGFHEQGPRVEEEVLERVQREVETCDAFAGFLTLMSVAGGTGSGVGTRITQMLQDNYPHAFLFNHLIWPHGTGEVILQNYNAILSLAHLYQSADAILISHNDAVRTVCSQLATTAKQNVSFQDMNKLIAHQMSIALQPAHLASSGRRPSSFGFMMEHLVPHPEYKLLTLRSVPQVSEAALAFSTFNYRSLVSRLRQMLITGTVIEEGINWHMKLPSKPSPSSLHNKSLAAFLTVRGKESDKVDLAEFDNSALYADWVPNSAAFAAQWHERPFSGHEKTASLLSNCQTPVWMLDQVLGKAWGMFAMRAYVHWYTRYGVTEEEFIDCFAGLEQVVQNYKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A857</accession>
    <name>A0A914A857_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060047.1">
        <property type="nucleotide sequence ID" value="XM_038204119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A857"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204119.1">
        <property type="protein sequence ID" value="XP_038060047.1"/>
        <property type="gene ID" value="LOC119731106"/>
    </dbReference>
    <dbReference type="GeneID" id="119731106"/>
    <dbReference type="OMA" id="THADSNC"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037457719" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="67"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="25032" checksum="AF8D26351CE8E5C7" modified="2023-02-22" version="1">MIKMKCLLIAVFAVVVQCCLFAATTHADSNCDSCLEAALRPLYSQLDVFRDQLDAVHVSCKKDVLNCSEVGPLGMEDHRIPDASITASSFWGNRADHAPHRARLNFEGGLASSWSSAGDSDPNPWIQVDLGCNVIITSLITQGRGDHDQWVTEFQVAYSDNGQEWTDVTAEGECAPTKFPGNSDRNTHVTTTFPKAFHARFLRILPTQWSMHCSMRFEILGCKSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAC8</accession>
    <name>A0A914AAC8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060810.1">
        <property type="nucleotide sequence ID" value="XM_038204882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204882.1">
        <property type="protein sequence ID" value="XP_038060810.1"/>
        <property type="gene ID" value="LOC119731674"/>
    </dbReference>
    <dbReference type="GeneID" id="119731674"/>
    <dbReference type="OMA" id="TLNMEAQ"/>
    <dbReference type="OrthoDB" id="10070555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="583" mass="69084" checksum="9882DCEE8736DC11" modified="2023-02-22" version="1">MKTMSSGKLAMPFDVGQKSKSRYETLATFGGDEGEEAKEYAAFLREQERKCGPEGFLDSRKYTHSFQVRGKVLESKSNKPKKPEDEEQPKPTQVGLLGTGAVPSKKPSQEGSKIDTVVDLLNRVEKDKDEYEKRMKVIEDHMWQHKQEERELKRSEGDIIKSQHMLRRTMKDFELAINRKKQAEAKKILENKQKEFLITTDHIHKKENLTKDRIEKVINKDQQIKDEDRKAFLTIGDLERKYRAKVSEIELRRAEVQKLSEEFTDRMKTKEEETFALNKELADIALTINMEAQKQRKMAVDTSKDGKTESKDKIKADNEMEAQFDTKLRRNMGKAGQFENNKRRLSLDLAQSNVNMLEKNRDGGRQLLDTRNRLQENNATQRKLQEAALTAKLDFTNRKIAQKLQSHEVRKQRRLQHITALKKKEHEKELKDWEERFDKKQYESTRRGYEDTLKHAVRTVTKQEEIEHDLSNKVRTSEYARKQREQQCKRLQQQLAEMRRKNDQRIKQQMIEYYQKEKELEQKLLREQSELYKSHVNREEGYISLQQHRMMMKEDRIILDGTAKEHERLRKIGEKTELLNSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAN3</accession>
    <name>A0A914AAN3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras association domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060922.1">
        <property type="nucleotide sequence ID" value="XM_038204994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204994.1">
        <property type="protein sequence ID" value="XP_038060922.1"/>
        <property type="gene ID" value="LOC119731754"/>
    </dbReference>
    <dbReference type="GeneID" id="119731754"/>
    <dbReference type="OMA" id="ELMWRIE"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20885">
        <property type="entry name" value="C1_RASSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01778">
        <property type="entry name" value="RA_RASSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21892">
        <property type="entry name" value="SARAH_RASSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF10">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="406"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="9">
        <location>
            <begin position="497"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60592" checksum="89DD22E9A4FCA974" modified="2023-02-22" version="1">MRAADIDGTARETTTSSMNSAGRRHSQPATITHTGNTNNSNTAHETSANSTGLLASLWTKMSEYVELRTLESHPSVSSTDSGRFSAGSDLFDSGESINGLLADKQAVQSAERPVQHRNGHQHKEHGHTHRNSIWNYFFGGGGGGGGGTSSDTKQSSSVTKSKPPSRKNSSTSSLEASGHRPRSASYSSPSLSASANHTKVKESIPTAAETEFAANGTNTWLEWNPLGDEDDSDSSDSSSLVAEDELLHQGTGEGHNFVPVFSNFTWCDQCGGVIWGFRQCLRCSYCKYTCHYKCLNEVKLDCDESPVFKEAPSESPQHTIVAIQDGVEDTSSLTGLSREELMWRIEEFNRKVESYPIKLESDSLIFVGSLRIYMNLSRPISIPSGSPLPKVCSTLRPYDHSVDHSKRRTSFFLPKNTYEDIQIASESTAIQVIQGVLSHIQVIDNCRKFALFERSEENGEVLMRKLADEDKPLLLRLLWGGDNATKRYELRENETGQIEWEAFTVPELQNFLRILDKEEQDHIEQVQNKYLVYEKRLKDAMAYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACU7</accession>
    <name>A0A914ACU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061662.1">
        <property type="nucleotide sequence ID" value="XM_038205734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205734.1">
        <property type="protein sequence ID" value="XP_038061662.1"/>
        <property type="gene ID" value="LOC119732274"/>
    </dbReference>
    <dbReference type="GeneID" id="119732274"/>
    <dbReference type="OMA" id="RYWAITQ"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="52"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="480" mass="53308" checksum="CAF2ABABA4C8C064" modified="2023-02-22" version="1">METQVMETVFTETSMWITENISSTPSGDSIPFSTYALAVFVASMMILITVAPNIMMIVLVIVDRKLRKLSNYYIISLAVADCIVGAVVMPCMASYSILGFWALGGVVCDVWITFDFMCCTASMLSLCMISLDRYWAITRPLKHMGRRSRKRALFYVAGIWVASAVCWVPAIVAFRLVYGSFGKYDCIYLTDPIYVLISAILVYYMPMAAMIYLYVKVYISVKSQFKSLESFENSPIDKPKTSQSTKVDGVLNNSGTSATTILSTTLSEIATNDVSAAYMNRGYMGSTQSLNEVQVESALSNERPSPNDVIKTSGIAVGITGPDMNTSDMLENSTLCLTPTDDITLRSVSATVAGNQGTIVSAAEMRKVRLRKVQLKHAAINRRTARALGIIVVLFLICWLPFVVLFPINAFCNCVPVKLYDASYWLAYLNSTLNPFLYGFSLDFRRAFMRYFCKRCVPVTLQDVSNTEDSKGNLNQSQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADL6</accession>
    <name>A0A914ADL6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061902.1">
        <property type="nucleotide sequence ID" value="XM_038205974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205974.1">
        <property type="protein sequence ID" value="XP_038061902.1"/>
        <property type="gene ID" value="LOC119732450"/>
    </dbReference>
    <dbReference type="GeneID" id="119732450"/>
    <dbReference type="OMA" id="RITFDIF"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF49">
        <property type="entry name" value="FI08416P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="20426" checksum="AD08B5FEF3C65D74" modified="2023-02-22" version="1">MICLSDSIVKRGRTPTDDVSCTLHTDCGNVQNVLHKSPAKSVFHFLDFQTKFALYDKRGDGKIGSEELGDALRATGLNPSAEEVTKITQGFIGGHRITFDEFLALHASLRSTSQTKGTVQEFTEGLQMLDRDQNNLIPASELRHVLTSLGEQMTEEEVDKLLTKFTDSRGMVNYPEFVKKVMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADR3</accession>
    <name>A0A914ADR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD repeat-containing protein WRAP73</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062075.1">
        <property type="nucleotide sequence ID" value="XM_038206147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206147.1">
        <property type="protein sequence ID" value="XP_038062075.1"/>
        <property type="gene ID" value="LOC119732577"/>
    </dbReference>
    <dbReference type="GeneID" id="119732577"/>
    <dbReference type="CTD" id="49856"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51446" checksum="51DA025A50759543" modified="2023-02-22" version="1">MNFSEPFKQSSHICKFSPNGKYLANTLQYRLIVRDVQSLQILQLYTCLDAVQHIEWSSDSAFILCGMFKRGIVQVWSLEQPEWTCKIDEGSAGLIAVRWSPDGRHILTTAEFHLRITVWSLVTKSVSYIKYPKEAKQPLHFSRDGKYLALAERRDCKDFISVFACNTWQLVKHFETDTRDMAGLEWSPDGRVLCVWDSLLEYKVLLYSVDGRCLATFKAYDYALGIKSIAWSPTSQFLAIGSFDQKVRVLNHVTWKTVVEHAHPPNLDSGSVVLYKEVEKRPQLVREGGRGVSNQTNWRPDASMFSVQSKYEVLTEGSIQIPVVKPDPDKANPKVGISQLSFSPDNRYMASKNDNMPNALWIWDVQKLCQSVLLLQVNAIKCMQWDPIRARLAVCTGNNKLYMWSPAGCVSVEVPAEASFQVNWLQWHPDGNAILLMSKDQMCVCFLSEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEG1</accession>
    <name>A0A914AEG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061749.1">
        <property type="nucleotide sequence ID" value="XM_038205821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205821.1">
        <property type="protein sequence ID" value="XP_038061749.1"/>
        <property type="gene ID" value="LOC119732363"/>
    </dbReference>
    <dbReference type="GeneID" id="119732363"/>
    <dbReference type="OMA" id="CTIRRAY"/>
    <dbReference type="OrthoDB" id="6356110at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="226"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="382"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="529"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="672" mass="75445" checksum="88F55BC56E509AF6" modified="2023-02-22" version="1">MSTTSAGAGAWLDQMCQSSALFSVCKLPKQPTYQSRFCGWNVEELKVRDQCYFPSTLLGPTQSDKTWTEAENKCREYGGHLTTAKDLDEQNLVRTLPNVLRSCQETWAVSKSGELWQKQCTNETRREILISNIALLFFHSQSWSDGTWFDIYTDYSEFPGGQLPENVVDEEDCTELRIWQNGEWGRSACGNSLKFVCKRNEISTIPLQPLPGYPTTGECPQDYFRLDNMCFSLRGRDESQRKGWIHARDDCKTASVAGTTLATVSNPGQQALLTAIIKGVGAEAWIGLNGIGVHDQYHWTDATRLDYTSWAPGQPDNALPITDPNSASCVAMMNDPNDPGLWNDATCTIRRAYLCQSPLVMSGGDPPPLPGNPCTDTKYTNYFDTCFLMESTYKRSFDSASFDCHGRDGSLLSVNDRYAGALFTYLLYQAGTDASDDEAWLGMRRNPATGVFEWIDKWPLTFTKWGPNEPNNNNGDCVALTRDGFWAVRQCYVYNYYFCKYPSTPPYVPGQRGGICPPDYVEFPGLDDCYLFNTSATMIKQEAGDLTCAINHDGGKLPSIHSKDEEDFIKAKTKEVFGENAQIWLGVTRNADDFNTWFDQSLMDYVNWDVNEPTDDNNANNNGVLLDVNGGWSDVASTERHNYICKSPKCRNHFALGHFNLKAHTCEYVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF38</accession>
    <name>A0A914AF38_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038062131.1">
        <property type="nucleotide sequence ID" value="XM_038206203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF38"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206203.1">
        <property type="protein sequence ID" value="XP_038062131.1"/>
        <property type="gene ID" value="LOC119732620"/>
    </dbReference>
    <dbReference type="GeneID" id="119732620"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="56"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="459" mass="50626" checksum="530828F0B81CA93B" modified="2023-02-22" version="1">MTSVRVRSRRVLLRDNATIGPAVVEITNGKITRIMEGKGYNGHWDAQKDIDAGSHLVMPGIVDSHVHVNEPGRTEWEGYETATKAAAAGGITTIVDMPLNCIPSTITLDAFRTKLDYAAKMAYVDVAFWGGVVPGNQLELKPMIRAGISGFKCFLIHSGVDEFPHVTEADLHKAMKELQGTDSVLLFHAEVETNLPPDESETSPTAYETFLKSRPKAMENEAIRLVARLCLQYRVPCHIVHLSSAEALPIILDARKQGAPITVETCHHYLSLDAETVPSGATQFKCCPPIREQENQARLWSAVNNGDIDLIVSDHSPCTADLKLTQEGDFMKAWGGISSLQFGLSLFWTGSRSRGMHIHELVRLMCERTALLAGLADRKGQLKVGMDGDLVIWDPEAEFQVTRDKIQHRNKLTPYEGKVLKGVIHKTLVRGQAVYDRGQHSQAPLGKLLFRGQHASSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFA3</accession>
    <name>A0A914AFA3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 192</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM192 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062422.1">
        <property type="nucleotide sequence ID" value="XM_038206494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFA3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206494.1">
        <property type="protein sequence ID" value="XP_038062422.1"/>
        <property type="gene ID" value="LOC119732911"/>
    </dbReference>
    <dbReference type="GeneID" id="119732911"/>
    <dbReference type="OMA" id="FFFNERE"/>
    <dbReference type="OrthoDB" id="6277625at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029399">
        <property type="entry name" value="TMEM192"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14802">
        <property type="entry name" value="TMEM192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="289" mass="33308" checksum="FB911606C6966FD8" modified="2023-02-22" version="1">MVSLGDGRNGGRQEGGFFFNEREPSIVQSPEEDELLITQHLQAEEEPNYKQCNTVWVAVCQMILIIVYLSASVVLPYGIEPKISHNSTEVQLEESFTYIAFSQPCVWLLLLVADRYLQYKHTLLRRHGYLDFTQKTRYLRRTAEFMFSLGNATMLVVVMLRYTIMTQMNIIRPVGTTSIHGVNYQEMIIGIESIIALFCCGRYAMLVCKFNKAKLPPDAEHEEQMIAVMQPSTHLPDIGYRDSQYVDALLERQADMIRYLKHHTEYLSKRILKLRALQNDGRLMGSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHF4</accession>
    <name>A0A914AHF4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063152.1">
        <property type="nucleotide sequence ID" value="XM_038207224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHF4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207224.1">
        <property type="protein sequence ID" value="XP_038063152.1"/>
        <property type="gene ID" value="LOC119733855"/>
    </dbReference>
    <dbReference type="GeneID" id="119733855"/>
    <dbReference type="OrthoDB" id="8044756at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="121"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="253" mass="25852" checksum="A5A182F039128109" modified="2023-02-22" version="1">ALLLGNSVNLRASVTGPVASDGDGPASQACPMCCQGSAAIPGIPGLPGSLGQPGSKGEPGQKGDIGSIGPMGERGTAGPQGDEGIGQPGKIGPRGVPGVVGPTGETGVKGQKGEPGEAPDDSNQRVAFTVVRTSDSDTLSSDRLPFQATETLLPGTSFDLETGTFTCGVPGTYVFMFSVCKYYSSSSLHVQLRKNGDAVVSGYSSDSSHHEQVSGSAVVVLQRGDTMYLTMHGRAYSSSYHETSFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHM0</accession>
    <name>A0A914AHM0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063178.1">
        <property type="nucleotide sequence ID" value="XM_038207250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207250.1">
        <property type="protein sequence ID" value="XP_038063178.1"/>
        <property type="gene ID" value="LOC119733886"/>
    </dbReference>
    <dbReference type="GeneID" id="119733886"/>
    <dbReference type="OrthoDB" id="71166at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="460" mass="52371" checksum="81257E387943482B" modified="2023-02-22" version="1">MPGSCCAVFGCCHRGGHTFPKDKKIRNQWRRAIKRDSFKPIRPWWPTASSLVCKAHFLDSDYEEKSVLGFKVNKKKLKKTAVPSQFAWSKVEPSSPALSREKRLKERNEKRRLEKEEVKQDECRKGESAENDAVVQDLNLAMQVDIESVPVIQEVHIQTDPLPNYSTCTSETQTEFNPSPLGKRVPSAGPASKVKRRYSRGYRKSQEHLEAVRRAVEEALQDTSYIKRTAAKYNLEYHFLYRRVLGTVEVESRNGPDPVHSADEEKNIAHFISEMALRGMGLGPSNVMDLVQNFLQQEKRKTVFHNNRPGYTWYYAFSARHGLALRKGSSLEASRAKVTPAKLDEWFSKYKRFMSYRNLLDQPHRIWNADETGFTMGSKTTKVMAPEMSSHPIPQLSGGSLKNRFTVMYCANAEGAMIPPFIIFPNKKPTGYDPLVGATIGAHAEYTDKGWMDASTFSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIK3</accession>
    <name>A0A914AIK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063234.1">
        <property type="nucleotide sequence ID" value="XM_038207306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207306.1">
        <property type="protein sequence ID" value="XP_038063234.1"/>
        <property type="gene ID" value="LOC119733945"/>
    </dbReference>
    <dbReference type="GeneID" id="119733945"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16114" checksum="75F34900DA5B058B" modified="2023-02-22" version="1">MSGAVSNSLEGPDGGRPGWVAVLALWTNNLMVIGITKGLGIMLPILQIQLTSQMWILGWIASLTIATSGFVAPFGGLVSRRFGAGYAMMTCGVMMSAAAIAGSFVENSLQLALLYTLLAGTAIGISSVVAKEAVGRCFTKNYATAMASHGPASPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK56</accession>
    <name>A0A914AK56_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063794.1">
        <property type="nucleotide sequence ID" value="XM_038207866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207866.1">
        <property type="protein sequence ID" value="XP_038063794.1"/>
        <property type="gene ID" value="LOC119734374"/>
    </dbReference>
    <dbReference type="GeneID" id="119734374"/>
    <dbReference type="OMA" id="DESTWIC"/>
    <dbReference type="OrthoDB" id="9944327at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037010798" evidence="2">
        <location>
            <begin position="18"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="862" mass="98995" checksum="9FE7B8CD292E45E8" modified="2023-02-22" version="1">MYRVVLFLALCGLLAQAAVPSRDASLIDSADNPFNSQTSVDQPSRTGSLWSWFSDGFNYLRGLFWEQEAPKYRPFPPYQELCDPQVSFGYQARSYPKSVWVGLNMTGRFSDVAVLLARPKLEEYFNGKNSRNMTITMTSPLRLKTPRSSGQWGPGYEEKTLIYSMYLPPQLHDNPPEPTDPDMFIIEEEPERYFVITFPSYTYAFLDFQKRNELEDLLNGQREEFLREFFFVDVYNTQTEVTGRQNEVLLLFNPDVQKPNCAPLQKTALPSIPVVPVPEALINNASDPGFTQLCTGAEYDARQYDRAVWVSVTINAISSDVGKFDAFPKLDHYIKGHNDQGVKIEKTLPVRITQEWPKSPYAYNIYRDYTYAYYLPPELYKGIPQPLDPAVRILDEPSAVMFALNYTGFSFEFRDEQMLQKLQNLLIDAGELYMSSRRWARNQYYPSYQVTDCRNDILVYMDPLAKSPRCASACEHRGKECPSYRVLQSLTDDIQRRHISGNLYVLRRTNTCNMTTAYNVAYMPLHRYFRGANNRNESIARPTPVILVHKSTDNPPQGCDFSYNLMFYLPSEKHQNAPEPTEEGVELFRLEARDTFVITFEESSTEEVVDTKLARMKGELDRLELCYARDEFAVATYDAPWRPQPHRHEIWIPQATCARPRPEGSPQYSIQGSGCDVGTECPTYEIVRSYSTFEERLYQRTDLWVCKVTTNCNIEDAFNEAITPLYEYYQSCYDVEPKARPVMSSMSLLDFLSTECNKVIETCAFLPEIGRSLPEQPDNDLILHYYPSESSESQATVYMTALQGPPSVELIQSGITTLLRDVTDADLLHNNKVFVARYTLPWEDDDAKTEVGVQAETLAHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AL16</accession>
    <name>A0A914AL16_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064124.1">
        <property type="nucleotide sequence ID" value="XM_038208196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AL16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208196.1">
        <property type="protein sequence ID" value="XP_038064124.1"/>
        <property type="gene ID" value="LOC119734672"/>
    </dbReference>
    <dbReference type="GeneID" id="119734672"/>
    <dbReference type="OMA" id="YGGPDNP"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="408" mass="46276" checksum="16A0CFB1452D05F0" modified="2023-02-22" version="1">MMLYNWKRMSRLLRTVLVMGTVYLMLCFAAVLTLLPSESKEDHENQPSKIQAVQVEAWHASAKRGGRPRNIFFSSEGREEVNQPAKVESHLNPDPKTLNISKTFMDSKESKKANIPTTLKNNFRQTELSDVFIGVKTTEIYHDTRLPVLFETWLDSSDVRKQTYFFTDADSPKYSKETGGQFINTHCAAKHTRQGLCCKMGAIFSMYLQSGKRWWCNVDDDNYLNIDNLLKLLRSYQHDKDYYLGRSSTSAEITVYDVGDKTLDKSKISQMRSTRRQTTFWFATGGAGVCISRSLALKMSPYAGIGGFPQICNRINLPDDVSIAFLIVDLLGVPLTKISDMHSHLAMLRNLNENQIKRAVTLSYKINSEKATNSVILKNAAFDTTVDPTRFKSLHCMLNPEASVCSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM05</accession>
    <name>A0A914AM05_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065060.1">
        <property type="nucleotide sequence ID" value="XM_038209132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AM05"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209132.1">
        <property type="protein sequence ID" value="XP_038065060.1"/>
        <property type="gene ID" value="LOC119735432"/>
    </dbReference>
    <dbReference type="GeneID" id="119735432"/>
    <dbReference type="OMA" id="EWELHHE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="159"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="70408" checksum="BED739491836F9CE" modified="2023-02-22" version="1">MASVGSAFEKIGTHLECSICTDKYKQPKVLNCLHSFCEGCLVKYRDGTYGGAPQIPCPVCRQETVLPQSGIQGLKTNFHLVSLIEEFELQKKVVCLEDPKLFCETCDEDNEALHHCLDCGLNICTSCHKTHLRFPVSANHVVATLNDIRQGKVNLIKQADQSKCHKHKEGLKQFYCKTCNELICQVCTVVDHPTAKHDITDTGTASKEYRQSLKDDFSALGRDIQSLELSLQDTIEAKTIVKDNMAKARKGVQDRAAEFIAKVKAEEKRLLDEVTTHEREQTEELDEHEKTLSDMLRKKRHSYSTGKDVTSNASDCNLISLYPVISKDLTKMNSQHPPQYPLKLWYLRFKKSQTDIDLGEVEQEGDKWELQHAFGKQGSGEGEFKFARGIAAAAEPDEIAVADWTNKRVVICNNQGQTKNIIQVVANDVVAVSNQWVCADDKKVMVYQRDTTHKFDFHTLPEDEVGKTDGQLRSVVVMPNGNILGGDEKRKVLIELDPRNGDIIHTMPVKIRPSFLAVLSNGWIVISEWEQGLVEIVEVSNGIAVTVDTIQPTIDGKPVKYCKGVCSNSSGIYLAVDTGYNTGHIHHYDCTGHFVSCVVHGLYDPHGITFTAAGQQLAVADLYSVKIYNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN04</accession>
    <name>A0A914AN04_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064886.1">
        <property type="nucleotide sequence ID" value="XM_038208958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AN04"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208958.1">
        <property type="protein sequence ID" value="XP_038064886.1"/>
        <property type="gene ID" value="LOC119735253"/>
    </dbReference>
    <dbReference type="GeneID" id="119735253"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="445" mass="49037" checksum="C8DBAAFF26ADB1DA" modified="2023-02-22" version="1">MVSIDPGGTLKIVCSNCSTTYLSKSYRCTDYSEVEDWQTGIGSTTFTADPGMEDFYISYDNCCWITLNNGGWTRYDALAHVDLNPYNGVINSSPNTSMSTIRVQHGCSQELHIPGTETCVLALGSSLSIGWYAVTINVEDFASASSTTPKSSVPLQFLIQVYYSPDPCSDKPSFVAPTPEDGACYGIAPGMELSFPIRAARGITAEIVLFQKVSPSNLETSAISYFNNSAGPDEYFTTVTWTPTESQIGRHVVCFSALDENSRTSPTRCVNLRVEDDAPTAIRASLDPSESDLWRLELMFSHNVSLPTSSAFVRIYLNGSLVYSVDVSLLSNASLIAKEDTFQIFLPSANLTMGQSYYVMLDGGVAVGPEPCPISSKAMVIGTKGEKYRQSWILNTRMNESSEPSCVQSARNVYMRDMPRPRKEQRIEHVEQYAHIESPTYRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANC0</accession>
    <name>A0A914ANC0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064996.1">
        <property type="nucleotide sequence ID" value="XM_038209068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANC0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209068.1">
        <property type="protein sequence ID" value="XP_038064996.1"/>
        <property type="gene ID" value="LOC119735370"/>
    </dbReference>
    <dbReference type="GeneID" id="119735370"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="309" mass="35834" checksum="3232E94877169B11" modified="2023-02-22" version="1">MDKVIPADLYQKLLSQPLHFGYVEHEGIILYEEGDDVVKALKTFEVRDDDSWIVTYPKAGTTWVQEIMSCVMHDGKLEEVNKRHTAFRVPFIEFNLPKTIRQENKLPLTYQAVEQIPSPRVIKSHLPGQLLPPNIWDKSKVVYVIRNPKDVVVSYFYFLKLINPNDRSGQTFSEFFDEMMSGKILYGPWWDHYLSFWKMRHHPNVLLLRFEDLKRDLRGNVEKVSKFLGKDMPAETLDAITDHCTFANMKKNPMANPDSILADTAPREGSFMRKGKVGDWKSHFTVAQNEAMDALIRDKCYGTGLTFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP17</accession>
    <name>A0A914AP17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065770.1">
        <property type="nucleotide sequence ID" value="XM_038209842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209842.1">
        <property type="protein sequence ID" value="XP_038065770.1"/>
        <property type="gene ID" value="LOC119735896"/>
    </dbReference>
    <dbReference type="GeneID" id="119735896"/>
    <dbReference type="OMA" id="GCENINE"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF210">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="569" mass="62985" checksum="EBC8EF45A2F62FB8" modified="2023-02-22" version="1">MYASIRNECCPGWRRDRYGRCSMAICSTYCPSSRGSCISPNVCRCKRGYYGRSCQYDINECQSESSNQCAQICINTVGSYRCECNTGYRLDSNGRGCWDIDECTMSRTHDCHHRCVNTPGSYRCECYRGYNLRADGKECGDNDECARMSDNCEQICINLAGSYHCSCSMGYDLVSGRHCSDIDECELGRPHHDCDQICTNAAGTFNCSCADGYQLGMDGKTCLDVDECAPPMNCDMIKICDVTDQLQPNCSYVSGSVTDIGECDDVNACSVVDYNCTELQVCQLISLTLTCACIERDGHALTESSRAVSGSLSADPSSIRRCETDAYGSLNCALYRGYQLIIDNTFCEDWIKHNCTEMQACRNTVGGYECPCKAGYITNTDTRECDDIDECSTDYMNCPEEKVQICQTDVNGTIECRCVRGRLEECRGDNCDLCDGGVRVCRDDNTCTCFREYFLNTDNTPCKGGGCGEMIHDCTEMENCVNTIGGYNCTCIEGYVRDDVSGYCADVNECDDGTALCNHICLNLIGNYSCACVEGFMLDPDGYTCRMRVGLYGLVIQPEEKQALCIVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQU1</accession>
    <name>A0A914AQU1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066018.1">
        <property type="nucleotide sequence ID" value="XM_038210090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQU1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210090.1">
        <property type="protein sequence ID" value="XP_038066018.1"/>
        <property type="gene ID" value="LOC119736085"/>
    </dbReference>
    <dbReference type="GeneID" id="119736085"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="14">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="475"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="88374" checksum="6441C84165654924" modified="2023-02-22" version="1">MPGVDPREAYLQLAEVTVENVTSGECAALPVYGKNTSQSSTWDAHPSYKAIDGRKYTYTHTDANDPHPWWLLKLGSKHCLGRINVTLRMNGWGFRFIGAIARAGLSPNFNENLPCGSPATSEQSQNGAEITFLCEPPRLARYVSLDINTSMPGVDAARAFLQLAELAVEEYTSGECAAPGYLGCFGDAEYRSLSVGPAATEYEQSVEWCFRNCLEPTEYKYAGMEYKYECWCGNDNYDKHGKEPDSDCKYFCPGNSNQICGGKWRISVYTVSQGVCSNDIGPPTNGDHTITNPRSLSYNLINFKFFGTRVDFSCDPGYTLHGASSIECIETGYNNVTWSDSVPTCEDNVCINPNPCQNGGTCIPQSTGDFYNCSCSAGFSGGDCQNAIANTTTINVVVVIVVVVVVLIVVLVIVVVCFVKRSRRKRRGSRLSAVDRGCGQELIQKKLSNVYLIDTLQASTSKLNGPAKEFPRDKLHILGQLGSGSFAVVYKAEAEGIIRRGTNTTVAVKMLKECATPNDQSDFKKELRLYSMLDRHPNVLSMLGYCTDKDPMYIILEYVPYRDLQTYLRHIRTGTEPFYLKKEEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHRDLATRNILLGEGLVCKVSDFGLARDVAEKSQYEMQSQGRVPVRWMAPESLISNMYTSKSDVWSFGVLLWELVTLGSHPYPGMSSQNVIDEIKQGYRLPKPEHCSDDIYQIMMDCWQEKPEDRPDFAGLHTTIDDILADAAGYLEMGNLNPEDYVYLKPGQGSNSITCSLTRSATGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQZ3</accession>
    <name>A0A914AQZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066187.1">
        <property type="nucleotide sequence ID" value="XM_038210259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210259.1">
        <property type="protein sequence ID" value="XP_038066187.1"/>
        <property type="gene ID" value="LOC119736224"/>
    </dbReference>
    <dbReference type="GeneID" id="119736224"/>
    <dbReference type="OMA" id="HIHARAG"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000525">
        <property type="entry name" value="Fat-like cadherin-related tumor suppressor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF13">
        <property type="entry name" value="PROTEIN CRUMBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036721001" description="EGF-like domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="504"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="732"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="770"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="808"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="848"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="886"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="924"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="962"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1129" mass="117975" checksum="B1D58752847605F5" modified="2023-02-22" version="1">MVGLILLTLAVCHGVSAYTLQEPDTKLDELLYRDLGFLDRMLIEERSEAETSKMNLVGKPVKQSSQYGSAKPQRAIDGVLNSNWAGKSCSSTKFQRNPYWQVDLQTEHCISKVTVLNRRDCCPARLHSALVRAGPSVEVAYIPACGTRVTKQEAFVRGGTIVRECERPLRARYITVGILSSRAMLTICEVEAYELPMLYCIDECESDPCQNGATCEDGLGEFSCICESGFTGAFCETNIDECASDPCKNGATCEDGINQFSCTCATGFTGTLCETNIDECASDPCQNDATCEDGINEASCTCAAGYTGALCESNIDECASDPCKNGATCADGINDVSCTCAEGFTGALCETNIDDCAIDPCQNGATCVDGINKVSCKCADGFIGSLCETNIDDCASNPCLNGATCTDGIKQVLCTCAEGFTGALCETNIDDCASDPCLNDGTCADGINEVTCTCAIGFTGSLCEIDIDNCASDPCLNGATCKDDINQVSCTCVQGFTGALCETNIDECASDPCQNGATCADGINEVSCTCAEGFTGALCETNIDECASDPCLNGATCADGINKVTCTCAEGFTGVLCETDINHCASDPCQNGATCQDGINEVSCTCAEGFTGSLCETNIDECASDPCKNGATCKDGVNEVSCTCAEGFTGAVCETNIDECARGPCLNGATCEDGINQVTCTCAKGFIGSLCETDINHCASDPCQNGATCQDGINEVSCTCAEGFTGFLCETNIDECASDPCKNGATCKDGVNEFSCTCAEGFTGDLCETNINHCASDPCQNGATCQDGMNEVSCTCAEGFTGPFCDSNIDECASDPCLNGATCQDGINEVFCTCAEGFTGPRCETILPKNPCDSDPCMNDGICIPEADSFSCDCAQGFQGNTCEINIDECASDPCQNGGNCVDSINKVSCTCAKGYTGVLCQTKSNGCIKNPCKNGICIKDRIGGSVCVCSRGYEGAACEINTDECTSGPCQNGAACVDGINRVTCKCRQGFYGTLCESRSQAQAPFQLGNQMIPIQMPEVNSETSVLQVNLITAYCIKKVVVKKHGDCTSDRLTGAVVRAGTSATGLNNGICGSALTAQQAEVRRSTVDFVCDPPLTAQFVTVDIPLLRVTQPNTCEVTVEQAIPGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARS1</accession>
    <name>A0A914ARS1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066472.1">
        <property type="nucleotide sequence ID" value="XM_038210544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210544.1">
        <property type="protein sequence ID" value="XP_038066472.1"/>
        <property type="gene ID" value="LOC119736529"/>
    </dbReference>
    <dbReference type="GeneID" id="119736529"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029776">
        <property type="entry name" value="TMEM179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="24570" checksum="89A6DA56728AAD6B" modified="2023-02-22" version="1">MAVEGCLMITETVLYLAAFFSGLITAITVGISRESFGGDCILFGEVAWCNQTAFAFTQLGSNGVCGFSVGLDIIVAFYALVCCVYHVAVFFKWTKERRWIMLPAIIINAVCLALLFIDSCILSIGFNRFCGSLTSGTDTKVTVCSADLSGQNWNRPPSCKADQKVDHTAYSGGNWFGFLTTAQGASWFGVLFWLVLLISITIRRIRDRPVLDPSSDKAPIASNVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU34</accession>
    <name>A0A914AU34_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067188.1">
        <property type="nucleotide sequence ID" value="XM_038211260.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211260.1">
        <property type="protein sequence ID" value="XP_038067188.1"/>
        <property type="gene ID" value="LOC119737142"/>
    </dbReference>
    <dbReference type="GeneID" id="119737142"/>
    <dbReference type="OMA" id="TNACRTP"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1248"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1278"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="310"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="708"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1017"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1335"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1572" mass="175831" checksum="44B647E45BB5896C" modified="2023-02-22" version="1">MAQSIGWQWLCGLNSSDLDRSGGFNLVNGHDNTCFVDALDTIPHLVFLLLSVVGLFLGCCIFFRKSNSEYLIRFPGHSIRWPVTIILLILLLASLAEGILTDETYIQSLGASRPHLYVPPICALVAISFSLVYYQYMEIWKVSGMAFLLVLYYAAAALGEIGRLINLLELDQRSVTITRFDLTILKLICFVVLLTLELNVIRLKVFCRCRHRDYDTLPEDLNSPGLLYRNDYVNFFSELVFWWVNWIFFLGYRQTLTTEDLGRLPKKLSAERLQQQFKEEFQKEKLKAAAKGRQPSLSKVIFRIYGLRMAWAGIMKLAGDFAGLVGPLCVAGIVLYVEDIYNEHESKEEVRPHFIDLTEFTANGFVLIGATFLASSFQFIMVHKSLFYSILYGMCVRSSIQTMVYEKSLSLSTYATTGGDMTAGQITNHMSTDPMNLLYMFQYFHFSWTVPFLVALVLYFLYEALGVAALLGAVVYVIVIPLQLGIANYMAIHQKKALFFADERLKHSNEILQGIKLLKSYGWEHLYLKVVENIRNNELLSLLKMNVCYGLIGFIVSASPLIVTVLTFGTYTAFSGEPLTADKAFSSLALFNILSGPLFMLPLITTAIVNGYISTMRLQKFFLAQEVEKSCMGEDWRERVDDGRGPYDYQHETTVDATEDGVMTSDVDEATHMLPKIKESKIKRPDGYQATNHTKTTKRSRLPKSVAIKITNGNFTWEKGSSVPIISNINVDIPAGKLTMVIGSVGSGKSSLVSAIQGEMTTLSGNVQFNESTLSVAYGAQKAWLINDTLKGNILFGEEFDNKKYKKTIDVCALKPDIEILPGGDQTEIGEKGINMSGGQKQRVSIARTVYSGRDIVILDDPLSALDVHVGSHVFRKAIVGNLLKKKRTVVLVTHQLQYLHHAHKIIVMKDGKIAYQGTLQDIIDEAPELYSEYQQAVKTATESETEADEIIMTMSDEEKREVFKRRLKRELSKDSQSSHTATKLIEEEEVERGSVSYKVYAYYCRAMTWTMSISFLLGYVANAGFTVGTNFWLAEWSTAGMTDDMNGNSTDDMLGYYIAGYAGLSVGGVVSVLIASLFIVFGAYIASRDLHMSMLQNITRCPMRFFDTTPLGRVLNRLAADTTLLDMKLYQSMDATVFFSVGYVSGLVVNSIILPIFLIFVVPMMVSYYFLAKFYVTTSRSLQRLDSVTKSPVFAHFSETLGGLSTIRAYRDQSRFYGSLLQKVNVNNTAFLYLQTTHRWAGMRMELIGVIGILVAGVGTIISSINGTIDPSQVGLAVSYTLVVANFMNFAVRFGAETEMQMNAIERIKEYSSISNENYKGTEPPESWPQRGEIKMKGIFVRYAKELDPVIKNVTATFKSGEKVGICGRTGSGKSSLTLALFRIIDTYKGSILIDDIDINTVPLTILRQRLAIIPQDPVLFNGTIRYNLDPENYRTDDELWDSLEISQLKETVSQMPKGLDSEVSEGGENFSVGQRQLFCLARAFLRRSKILIMDEATASIDMDTDKILQEVVATVFADCTVLTIAHRVATILDSDSILTLADGEVIEYDTPENLLADHNSIFASLVNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV91</accession>
    <name>A0A914AV91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067677.1">
        <property type="nucleotide sequence ID" value="XM_038211749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211749.1">
        <property type="protein sequence ID" value="XP_038067677.1"/>
        <property type="gene ID" value="LOC119737412"/>
    </dbReference>
    <dbReference type="GeneID" id="119737412"/>
    <dbReference type="OMA" id="ETHCHAA"/>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037861319" description="CUB domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="34045" checksum="35FEF49D6E5D45A5" modified="2023-02-22" version="1">MANLRRQRIIAVGFLMVFIGAANAAEIAKVFMDEKCGETIQAGRSGGQMDSQLSMYYANDFDCTVTITADIGRQILLTFDRVDIEGTPSGDSGCDGDYLEVYEGTSTILSPVQVICGMYASDIVSSLNSVTLRFKTDSSSIEEGFLLSYTSFKSPGLTSCDSDEFECDNDRCIDATLKNNFNDNCGDNSDEDPFGGLDDALNNAISLGIGIIVAIIIGCIVGVVLLCVCVGCICYHCCCKRSQPQQTSYQVVAQTPQQRQQPPMAMQPIGQPGQQAPYDQPGAYPPGQPAYPPGPPAYPAGQPVYPPGQPGGYPAGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVD2</accession>
    <name>A0A914AVD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067717.1">
        <property type="nucleotide sequence ID" value="XM_038211789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211789.1">
        <property type="protein sequence ID" value="XP_038067717.1"/>
        <property type="gene ID" value="LOC119737434"/>
    </dbReference>
    <dbReference type="GeneID" id="119737434"/>
    <dbReference type="OMA" id="TFILGHE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="249"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="53973" checksum="116E592A8A3C51F0" modified="2023-02-22" version="1">MLIRPNWRFIQSWMATHQQHSKIYLQCLSHRSQQMPRIQNILTNPQTRTPVTQQTRKLNTALYSSRLVTQPGRSKLDRPSCGPIQTYQLKTLCQQGGQVPSAVGFRTSSRHQALPPLLVLLFVKPIAKVTAIFSGRAFRNWWRALPHNKRQYFYAALRKHKYKILGVSLGLTGIGSAYYYSHLQMTPVTNRKRFIAFTDSQFKKIAATEYENMKSLHAEKCVHSSHPLYLTIARLVLRITQANNDIPEIRNRNWTIHIIDKDIKNAFVLPNGEIFVFAGILTAVTNEDQLGTILAHEIAHVVLNHAAEQVSLFQFVDVLLIVVLAALWAFLPNDGVAAVATWFKSKVVQLLLEMPYSRSLETEADEVGLVLAARSCMDVRECKAFWELMALRSNSGQDDDIDIEWLSTHPTHQNRADHLGSLLPGVLKLREECKCPPLPDIDPSAVVAKQRLLHLQEQEKRKKEPVIMSGIQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXN6</accession>
    <name>A0A914AXN6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068031.1">
        <property type="nucleotide sequence ID" value="XM_038212103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212103.1">
        <property type="protein sequence ID" value="XP_038068031.1"/>
        <property type="gene ID" value="LOC119737634"/>
    </dbReference>
    <dbReference type="GeneID" id="119737634"/>
    <dbReference type="OrthoDB" id="8955483at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="448" mass="50519" checksum="EAB92E181EE26081" modified="2023-02-22" version="1">MAAEGDAKNGASSLWTSKWTPIPQSEDGSGASDPELCGWVSTVEQAWSVKESFEIAKSLKFNADKSQKYTAGASHDPDAHTVLQHRIRFADVKEHVVPNDGVPFITASRSQMTCMFGRDKHAKRRKRAQEEREKCLKKKEDHPFKRHCRKLQASRKRGCPAAIIVKEVFRFVDYKVEAGCTTWQERKISKAIRTRLESGVLPKWEQRVYIRLPCDADHKESHSIGQHGHGLSCADALRRRAVSEDTIGKLKDLFESGHSPSSALDALKCDLREQHGEQYVYAADRSVCPDLQFCYRLYHKMFKKVYGEVSREETVFDLEKEFQNGGQSSRPTQDQDVQEQLQNMFDTLSRKLEDDPEVFRLPLQSFVSKFETIATDSALASALSSFAKHSTPAARQKIRTKKCLQTSTEIGLQPPTAVTKRKTPPGGRRALITGQPPKTARETEHGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXT5</accession>
    <name>A0A914AXT5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP-ribosylation factor-binding protein GGA1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068081.1">
        <property type="nucleotide sequence ID" value="XM_038212153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXT5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212153.1">
        <property type="protein sequence ID" value="XP_038068081.1"/>
        <property type="gene ID" value="LOC119737663"/>
    </dbReference>
    <dbReference type="GeneID" id="119737663"/>
    <dbReference type="OMA" id="SAPSQEM"/>
    <dbReference type="OrthoDB" id="447025at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14234">
        <property type="entry name" value="GAT_GGA_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03567">
        <property type="entry name" value="VHS_GGA_metazoan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000023">
        <property type="entry name" value="ADP-ribosylation factor-binding protein GGA3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF1">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="13">
        <location>
            <begin position="171"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="658"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="84210" checksum="611317D8B58EBEFA" modified="2023-02-22" version="1">MASADENETLETLLNKATSPMNRDEDWEYIMNFCDRVNIELEGPEISCRLLGHKMQSPQEREALQALTVVEACVKNCGESFHRQVGKFRFLNEMIKLISPKYLGTKSPESVKKKVIEMLYSWQAGLPQEPKIIEAYQMLKKQGLVKEDPVYMDKAYFPSPAPRPKNAAFEDEEKSKLLARLLKSKHPEDLQAANRLIKNMVKEDEKKTEKVSRRMNELESCNNNVKLLTEMMEHFQPGVTSEQEMELMKELYIACEKMRPNLFRLASDSEEKDDGIADVLQTNDAVVKVMETYKDKIGLASLEQPSSPGLLNNAPLAPPAQTQQEDSLLDLSGLDPAPAAVNNPSDGLPSFPPYTPPSSPLGAPGVTSTTQPSSTQLLHDQLSSLGIANSTAAQQIPPATQGFTRTSVTQKTSPTVLESMMGPIPSSNLPNYSIPQQQASSSVFDYQQPTNPLRPRMGAPVMARPTASGAAGVMVRPSQQMGSMGATIQPVGMSPNVNQAGARLPQYSRTPSGGGAAPPQGGGGAHSPFADLESLGKSMVKQQMNGVKQPVSTQQPIAAPQPTTQQQPPVSQPTSQTLPNQQLLTTMQSASQPVTQPPAQQPVQPLLPTAPGLTQPATQGTTQPTAQGTVPPVVASPSPATVLSLADVFVPLETVQPGTVAPITAYEKNLIKTVFHFAKNAPRPDITVLVVSTMSTNPSAVKSVVFQAAVPKTMRVKLQPPSATDLPAFNPILPPSAITQVMLIANPQKEKVRLKFKMQYTVNDQVTTDVGEVDKFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1A1</accession>
    <name>A0A914B1A1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in 20S pre-rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069569.1">
        <property type="nucleotide sequence ID" value="XM_038213641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1A1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213641.1">
        <property type="protein sequence ID" value="XP_038069569.1"/>
        <property type="gene ID" value="LOC119738705"/>
    </dbReference>
    <dbReference type="GeneID" id="119738705"/>
    <dbReference type="CTD" id="90121"/>
    <dbReference type="OMA" id="LAKDEWF"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="197" mass="21538" checksum="4FE58299CCB94733" modified="2023-02-22" version="1">MAASSETPLGIFHRSISSIFDGWTVLQLAVSHGYGGIHGREKALWLVDAVYTWFQENDGIEPEELEDFVAEIMDNEFDTRAEDGSLTVISQTICGNFDLCKAGRHAAVLQRIQEMPKASLGSCQAAVGQDTEDSEDGDVPPMLQEMMGNMDVGTSGGREPTLNGYPEHSEEQPSSTETPPAQTEDDGWTVVRKTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1N5</accession>
    <name>A0A914B1N5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069818.1">
        <property type="nucleotide sequence ID" value="XM_038213890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1N5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213890.1">
        <property type="protein sequence ID" value="XP_038069818.1"/>
        <property type="gene ID" value="LOC119739054"/>
    </dbReference>
    <dbReference type="GeneID" id="119739054"/>
    <dbReference type="OMA" id="GRKCIMI"/>
    <dbReference type="OrthoDB" id="10061340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="215"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="345" mass="39405" checksum="1FCE5BC2A30E8CBA" modified="2023-02-22" version="1">MNIFRKPILVSPKHLQRMRLRLQKYSLHVEYKQGSRMYLSDTLSRASLPTRQVTDQTPDYLIFSVTQEQKLNMELENIEPTIFVTDERLQRVKKATLADQTLQTLMQVIQAGWPGDKAQVPLCIREYWPYRDELSTQNGLIFRGTRIVIPTALHADMTARAHASHMGVQYTTNTARDIMYWPRMHTELVEAVQRCAICQESQPALPKEPLMTHPVPKTPWQLVASDCFEVNGQNYCVLVDLYSDYIDVRALEDMTSKSLIKELKPVFATHGIPHTLITDNGPNYVSCEFTQFANDWDFEHTTSSPYHSKSNGKAESAVKIAKGLVTHAWLRPTKSANSEPIVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B230</accession>
    <name>A0A914B230_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069556.1">
        <property type="nucleotide sequence ID" value="XM_038213628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B230"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213628.1">
        <property type="protein sequence ID" value="XP_038069556.1"/>
        <property type="gene ID" value="LOC119738700"/>
    </dbReference>
    <dbReference type="GeneID" id="119738700"/>
    <dbReference type="OMA" id="CESEHER"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16162">
        <property type="entry name" value="OCRE_RBM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12313">
        <property type="entry name" value="RRM1_RRM2_RBM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="195"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="320"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="951"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116074" checksum="E22BA25E333BA82B" modified="2023-02-22" version="1">MELEINQYLAQQREMAVDQADIRRDRGRDFGWDRNQGRERRRNRSRPSRFDDANENALQGQPRGNYETNVETNNYQEQELYQNNRRSEQRSEVYEDRRDEDRYSGDRYDDAKRYPRNEDRYRGSSSRYDDRQSDRYDERYEERYSEQRRGGDRHDDRRRSGRRSGGDRRGDRMDNDDRHREGRDRRPQEKEKPSRTVMLKNLHNSITDHDIRTVLQMFGAPIKDVRLVKHRDTGVSRGFAFVEFQFLPDAQRWMEENQGHIDLAGQDTQLVYSSNKDREEDWFCSQCGTHNFKRREYCFKCSISKEDSERYSEIGDVASNVLILMGLDALTTEETVTKVLEYISSATMNISIARDTLTRTSRGYCYVEMDTMETATHLMNILVSMQPPFQIDGKQVSVHFCKQSLPEESKTTNPVLTEAKWPAYGSQEDPASTQPPTPETSAGAALFYQQATPTLDPTKLTESQQYVYQPYVVQPAGSQLPAQAEYQVQGALVGSNMLASAVVKGTGVIADREQYKAAVAQEQVQAARRLQLQQQQVQQQLIVTAKLQEESKKQAAGKATTSTTTAAAADQEDQEALAEKARQWSEKKKRKKEEGDKEKASEEKDDGGAALAMASTKKKRRKKQESSSVTEAPVVPVFFQEGQKYPTPDVSKYVYDEISSFYYDPTVGLYYDANSQYYFDGTTQKYLYWDAAASTYLPAPDAKPEQTAANADTTDKAEKTKEKDKKDKNDKNKMAKKLAKDMARWAKSMNNSKANAAKKGGAGMEGGFSVIGAADAGFAMLMKKANPADTKAAVQHVLQKQTSDPGTAASKSAIVASYGGGSDSEPEPEIHPTFATVNPTAATSNVASTVDALTDWSKLICLLCKRQFPSKEILVKHQQFSELHKQNLESLRLDSQELRDQEAAETDYQYRDRAKERRQKFGVDEAPPKKKFRPPKPTVPYEEPTKEGLQEDNIGNKLLQKMGWNKGTGLGKKQQGRMDPIEVQKRQAGAGLGIKGGSYDITATDSYRDAVKKVMRNRFEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B247</accession>
    <name>A0A914B247_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069864.1">
        <property type="nucleotide sequence ID" value="XM_038213936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B247"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213936.1">
        <property type="protein sequence ID" value="XP_038069864.1"/>
        <property type="gene ID" value="LOC119739105"/>
    </dbReference>
    <dbReference type="GeneID" id="119739105"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="326" mass="36828" checksum="0D419E5B2D68099A" modified="2023-02-22" version="1">MNASSGNDENELEPTGGKWICQITAGGAVIGVLGNILVCFVILRVKFLHNMTNYLLVNLAVADLLMCLLIFFFDLTSGGNCALYHIAPTSSGARQLFCRLLVSGYFIWVTSCASGYNLCVVTLERYYAIVHPLQYARKLTATRMKILIALIWIISFLFSIPLVFNTQPSDDPDHTCSEIDYPHRVLSLLIGVFTFLVMYLLPITLTSLAYYKMQIALKRQVKALNLQHARAAAYDLVIARQRLVSMLTIVLGALVILWTPSYVGLLLCLRPTKNGYFLYCGSKGFKYFKAIADLLFYLNSVINPIIYAFKYKKFRQGFKFAWCRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B464</accession>
    <name>A0A914B464_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070285.1">
        <property type="nucleotide sequence ID" value="XM_038214357.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070286.1">
        <property type="nucleotide sequence ID" value="XM_038214358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B464"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214357.1">
        <property type="protein sequence ID" value="XP_038070285.1"/>
        <property type="gene ID" value="LOC119739411"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214358.1">
        <property type="protein sequence ID" value="XP_038070286.1"/>
        <property type="gene ID" value="LOC119739411"/>
    </dbReference>
    <dbReference type="GeneID" id="119739411"/>
    <dbReference type="OMA" id="INDSPMH"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275737" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="768" mass="85346" checksum="3339C6454DEE5C8A" modified="2023-02-22" version="1">MAAQNVKFLVLALCCCAVFADVQVNPLKFKDILYKSWSPPMQSMAQDSYDVSAECEAEINRLINSNPKTLETDVVMALDAFGKPPAGILQLNVAWLGHYDECMTIDGFNYCLIGLNVNTTKLSKSTTNKNIATSLGEVGLFGMKWGVCLPSNCSENDISAVLTHLLDALKVFESVNIPLDALEEQSVTCAKDPTIPYSAGVICTIILCGFIASLMIVGALYDEFLKLQAEKPLGPSLGLRIRRPWRLLDDSDEADDDDDVPILKDVGTAGPSINREGNEMKKQNLATRLLLCFALNRNLAKLMDTKQGDKTIGSLNGIRVISMTWVMLGHTLVFGLGSSDNLPTLLSWVKTHAGFQAIANAYFSVDSFFFLSGFLLAFLTFARFRELRSVKTWALFYFHRYWRLTPLLAFTILIWMYIPQFFGSGPLWQSSAARPLCSQYWWSDLLYINNFWPKAFEGECIAWTWYLANDMQFFIISPLLLAPLFYFPIFGWLALVATLIASFVSTGLIIGTNDLSVDLFGQTTQQKLPGADFSSMVYGKPYCRIAPYLVGIGLGYIMHRIGKRRVKMSPVLALLGWLAAAGLALSVVYGLYPTTHTPPMTKAANIVYGSVSRFVWALALAWVVFACKYGYGGWINTFLSWSAWVPLARVTFPAYLFHPIVIFVFYYNFASPFHFSVYLLAFYFAGVVSVSYLVAVLASLAIEYPFANLEKVLLPTPPRAKQLKDRSNPDTASTDVVTVVTGSPVRNSVAYDDSAYRRGVADSREVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B524</accession>
    <name>A0A914B524_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071173.1">
        <property type="nucleotide sequence ID" value="XM_038215245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B524"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215245.1">
        <property type="protein sequence ID" value="XP_038071173.1"/>
        <property type="gene ID" value="LOC119740044"/>
    </dbReference>
    <dbReference type="GeneID" id="119740044"/>
    <dbReference type="OMA" id="CKNDHCH"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="2">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="780" mass="84022" checksum="B2A9BAC2E418BC37" modified="2023-02-22" version="1">MSLETLPVNSDVTNGAVKEVATVIPCAPIMATAVQITIPIASTNIHIMALVKQPALIDVTPGAVKEDVPATQRLPVNSDVTHGAAKEDAIVILCAQLLATAVQITISIASIHIHMIALETLRATCVDRCYSWGSQGGCACDSACTYYDDCCSDFTSICKRTPGNDTFGDASCQFRCYTDGSQGGCYCDSVCPDYGDCCPDYQTYCVHSTPDDSGEASCQFRCYTWGGQGGCYCDSSCPYFGDCCPDYETYCVHSNPDDSGEATCVSRCYSWGSQGGCYCDSACPYFNDCCTDFNSICTRHPGPSTPGNASCVNRCYSWGSQGGCYCDSSCTFWGDCCSDFSSVCVRQPANDVFGDASCQFRCYTDGSQGGCYCDSVCSNYGDCCHDYNAYCIHSTPNDSGEGSCVNRCYSWGSQGGCFCDSACTYWGDCCLDFTSVCTRSPANNVFGDASCQFRCYQWGSQGGCYCDSVCPNYGDCCPDYHTYCIHKHPHYGAGKATCVDRCYSWGSQGGCACDSACTYFNDCCSDFTSVCTRAPGTDVFGDATCQFRCYTWGSQGGCYCDSVCPTFGDCCPDYNIYCVHSHPHDSSGEATCVDRCYSWGSQGGCACDSACTYYEDCCSDFTTVCKRTPGNDTFGDASCQFRCYTDGSQGGCYCDSVCPDYGDCCPDYQTYCVHSTPDDSGEATCVNRCYSWGSQGGCYCDSACTYFGDCCSDFTAVCTRQPGQSTPGDPSCQFRCYTWGGQGGCYCDSSCPYFGDCCPDYETYCVHSNPDDSGEVHLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6E1</accession>
    <name>A0A914B6E1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071529.1">
        <property type="nucleotide sequence ID" value="XM_038215601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215601.1">
        <property type="protein sequence ID" value="XP_038071529.1"/>
        <property type="gene ID" value="LOC119740339"/>
    </dbReference>
    <dbReference type="GeneID" id="119740339"/>
    <dbReference type="OMA" id="CCCATKS"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF23">
        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036688268" evidence="7">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="27160" checksum="5056371B152B8FA8" modified="2023-02-22" version="1">MALMWLVVRIVFVFVCFSPAFGEYCPGTYSNFWCPTYSDNDGQDECCQDNTPYNHCCYFDTDYESVYQLSVGAIVGIVIGSLILLGIIIAVIVAVCCCCCCATKSGAQGRRTGPTTVTHFQGGTQMTTMTAQSYSQGQPAYPGGQQVPTGQPPYPGQQAYPGQPQAYPGQPQAYPGQPQAYPGQPQGYPGQPMAYPGQPQAYPPPAGQYPGAQAASQYYPSTSAPAGQCPQPNVPGVIAGTGPSDPPPQYENSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6K2</accession>
    <name>A0A914B6K2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071836.1">
        <property type="nucleotide sequence ID" value="XM_038215908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6K2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215908.1">
        <property type="protein sequence ID" value="XP_038071836.1"/>
        <property type="gene ID" value="LOC119740565"/>
    </dbReference>
    <dbReference type="GeneID" id="119740565"/>
    <dbReference type="OMA" id="KHKYSLR"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315:SF26">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NRDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15315">
        <property type="entry name" value="RING FINGER PROTEIN 41, 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="625" mass="71722" checksum="C0B73891B1D6E6AF" modified="2023-02-22" version="1">MAPTRRASCKVARFASSKSQPPGNATNKGREKLTSSKAGKPSGLDGSDTVRRTRSQSALRSRENVQLRINNDVCNKESHRGHARGPEAVEQASISGICFNKECQTRKDMKQKKSCSKAVKDTKKRKRCTRCTSGKSKKRLKGDIQTEDISVQEAVPPAPSQKIESRKSTPEVPAKPQVDSGENASQASPDGHLEIKTRIGLIRQRILEEQARVRGLGDQLARNKDTERASLSCRRIRIHKELKKLREKVQLEDKRRLQAKDHRIQRQLEAGKRKVDSERWSMRTRLAKEWRDRFQRRKSEVRRAKQSLKAQIGAHQVDKRELLKQLQKDWTAQLSRVQAMRERLEMEMVRGGQQWDGEMWRTGTMGKHKYSLRRAPREKTHVYCRAWKMANKKVSSEPKKQDEKPPSGGTVYKETKQKTLMELYQILDSELRCSICSELFISAVVLNCSHTFCSFCIKQWKRRTDRCPICRASITSRNPISKLDPFLTKLCRRVGREVEKKRAETIKDRQGQEKELKEGGRTWGNFASHSLEDWDMDDDDDFNGSLDSDDDSDVDEFLEILQDRVGGSAFRRFFGFGLVDDLEGMDDSDDDLFSSSDEDLDSDDFEDLDSAFLGEDDDDEDDMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B724</accession>
    <name>A0A914B724_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071933.1">
        <property type="nucleotide sequence ID" value="XM_038216005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216005.1">
        <property type="protein sequence ID" value="XP_038071933.1"/>
        <property type="gene ID" value="LOC119740637"/>
    </dbReference>
    <dbReference type="GeneID" id="119740637"/>
    <dbReference type="OMA" id="THFKTEC"/>
    <dbReference type="OrthoDB" id="10064741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1437"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1740"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1757" mass="198211" checksum="27D8D52A09351C30" modified="2023-02-22" version="1">MISDDTTLTDVTITTTSQGTIPVCTSAQPAPSTSPVENRTVPDTSLRAIPSLTTAAVSQIPSMTTLVSGHPTPLCADGHAPMTTSHMSPHSAHQAQPVPTGSPPMVPGATAIDLLVASSYGIPKPALPRFSDGREKEFALLRMALDNLINVHPHLTEQYKFQVMLDRLGGRALKLAKSFMYTRQPYTEALAALTDRYGQPRQLVQCEIAAIMATPAIKYGDTEAFEEFSLDVLSLVGMLQSLEGPDGIELRCGSHVDRLLSKVAPSHRTSFMEHCLKEGILKSNCSQTYTLPQFASWLRRKSQSHSFASRAVSGHTLSNPRPQRYQEQRISRKDTPTAVLMTVPKPKYKPQPYCPFCDNKEHYLGGCPQLKKLNTDQIVSWIQDKGRCWKCGRAHKPDECTLKKPCHTCKQVHLTVLHDAAHKTTSHVFRVQTSSLNVYVDRPIRPHGVMLKVVPVLLHGPAGTIETYAILDDGSERSMLIQTAAEKLQLKGQPETVLLRTVRDDIVECQGSAMSLQVSPKGKPHIKYTINGAFSASNLCLSVYTYPVKALQQRYNHLRHLPLPVINQASPMLLLGADQTDLIIPQCPIRSGPRGAAVAIYTRLGWTLQGPTGNHDLQLEQRVFKTSTFPVTNDLLQHVQMLWQADVLPYANDKEVTRSKQDQYALKMLESKTTRVSLDGVQRYATPLLRTKDGNRFQVTKDAVLPTLRRAEKRLQKHPQLAKKHNELITKLVDSGHVRVLPDDEAAMSDESWFIPHHTVHHNGKYRLVFNCSFQYNNQVLNEHLLPGPQLGASLIGVLLRFRQHAIAISGDIKAMFHQVRLLPEDRPLFRFLWRNLKVEAEPQIHEWQVLPFGSTCSPCCATFALRKHASDHKEQYPEVAESVDKSFYVDNCLDSLPSSREAKHLVHQMRNLLADAGFEIRQWASNDPTVVEDLPPDARSNGCELWLTYGDTDSLEATLGLQWDCSTDNLQYRHRTVDYESLNMRNMYKILASQYDPIGYLTPFTTRARVIVQDLWKTKCNWDDVLEPGAIRDQWQAWEMELPALTDIQLDRCYTPLAVDVKPSSYQLHIFCDASERAYGAVAYLRAEDKHHHIHVSFVMARSRVAPKRQLSMPRLELSAALAGAQLCQLLKRELSLPVKYVVLWSDSTTVLTWLKSESCRYKVFVGTRVAEIQTLTDVKQWRYVNTKNNPADDLTRGKTLMELAQESRWRDGPPFLLSPPDQWPVHPATPPEDVSEYKKSTFCGAVAVDPEDPPDLSKCDTWEDLIMATKEHRDGAADTGDPPELGAEDRANIELLLYRRAQQGSFPDDLAALQAGRDLPRDSKLLQLAPEYDDFTGLIHVGGRLRQAEDIPKDSRHPIVMDPAHPITKLLIREYDEKLLHYGPERVLAEMRRKFWVLRGREAIRKHQRKCFGCQRWRANPDVPKMGDLPPARLRLYKPPFFSTGVDCFGPMTIKTGRRTEKRWGIIFKCMTTRAVHLDLLESLSADAYLMAVRRFVSRRGKPFEILSDCGTNFKGGASELHEAFSAMEPRLKEELSKQQVKFVFNPPKAPHFGGVWEREIKSVKAGLRVVLSQAVPEPVLRTVLIEIEGILNSKPLGYVSSDIADLDPVTPNLLLMGRHDAALPQVVYPARDLLSRRHWKHSQVLADHFWSRFIGLYLPSLQIRQKWQRDGAEMKPDDVVMIVDPALSRAQWPIGRVVDTFPGPDGRVRTASVRVRKKNYTRPVARLIRLPEVTNEGVKDDQENDKDPALMDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9E4</accession>
    <name>A0A914B9E4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072798.1">
        <property type="nucleotide sequence ID" value="XM_038216870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9E4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216870.1">
        <property type="protein sequence ID" value="XP_038072798.1"/>
        <property type="gene ID" value="LOC119741164"/>
    </dbReference>
    <dbReference type="GeneID" id="119741164"/>
    <dbReference type="CTD" id="11316"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000140">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="305" mass="34406" checksum="439642735DE935E7" modified="2023-02-22" version="1">MHHSIMAAQSDVDELFEIRNAFYLGNFQHCISEAHKLKPSTSDLKLMRDVFMYRAYIAGRNYGVVLDEVRSSSAPELQAVKMFADYMASPNKREKIVGDLDKKMSSSVDIDNDTFLLMAASIYYHEENFDAALRCLHQSESLECLALTIQTCLRIDRVDLAKKELKKMQEKDDDATLTQMAQAWFNLAVGGEKLQDAFYIFQELADKNASTPLLLNGQASAYLQQGKIEDAESILQEALEKESNNPETLINMIVLSQLLGKAPEVSNRYISQLKDSHASHPFLKDYLAKEAELDRLAKQYVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA47</accession>
    <name>A0A914BA47_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactosylceramide sulfotransferase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072874.1">
        <property type="nucleotide sequence ID" value="XM_038216946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA47"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216946.1">
        <property type="protein sequence ID" value="XP_038072874.1"/>
        <property type="gene ID" value="LOC119741214"/>
    </dbReference>
    <dbReference type="GeneID" id="119741214"/>
    <dbReference type="OMA" id="MFRFAER"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF86">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60970" checksum="CE5756FEBF897F9C" modified="2023-02-22" version="1">MCVQYLCTQFACRASGLQEMFKKCSRNVQRKCRLLSKPVIYKPSKTSQSVLSIYYVCPDIVSDVTTVVMTLSKQVASVGLAVFLLLMVTVGYIQYDGIKHVVVDTSSKLRSSGIKSSLPNLHKFLGGTEGKTKNLTRVADVSTFLLKTLQLNATPNISRGTERQSEALQAVLIHREIAKANNASSSQAMANHDRAPSTNQGSGKSCNPRTNIVFFKMHKCSSSTIQNILFRYGEAHVLDFVLPPAGNYLGHSAFNKRYMIKFPVEEYNILCHHTVFNAKGMAEVMPVNSVYATILRDPVPMFESLFTYNNMAWQYHLPNNRGLELFLKKPEYYYRIADGGILHIKNPMLYGLGLPKAYLGDQSAIDRKIEELKGQFDLVMMTEYFDESLVLLRDLMCWEFDDVVYFVQNARSKSAVKAVSPQAATKIRKWNYGDTKLYETFNRTFWEKVEAFGFDRMKKEVAQLRERNEYYKKRCIAEVTNKNDRVWHPPGIPVDSFLLKKEASNDVMCNRMAEPELLYTAQIRQIQKKRYGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCH2</accession>
    <name>A0A914BCH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073716.1">
        <property type="nucleotide sequence ID" value="XM_038217788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217788.1">
        <property type="protein sequence ID" value="XP_038073716.1"/>
        <property type="gene ID" value="LOC119741866"/>
    </dbReference>
    <dbReference type="GeneID" id="119741866"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="294" mass="33587" checksum="5A8A41B13EA86A1E" modified="2023-02-22" version="1">MSAIDIITGARYALTGCAAVATVENLLVLVVFACTSRLRMKYYGFLINLTLADLFYAVMAIAFTWGGSEILFSIFFSGYFVGVWTILAEGINRYLAVSCVDTARYDVLVTRNRLVVVCVLIWIVSLTIQIVPEFVPHSPGEALFEGVIKPLTVFVFWLITAGLYIVVFRKIKGYTAPLASSPPLQTSCIEDQVRTRVRQTRRLLVTFTLILITSFICWMPFSVMQMVNYHHRDFEYEDAVFWITGMVYCLAPMINPWIYWMLVPGFKEGSRQMFWRRFNREVPAVYETVSETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCM9</accession>
    <name>A0A914BCM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain collagen C4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073804.1">
        <property type="nucleotide sequence ID" value="XM_038217876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217876.1">
        <property type="protein sequence ID" value="XP_038073804.1"/>
        <property type="gene ID" value="LOC119741923"/>
    </dbReference>
    <dbReference type="GeneID" id="119741923"/>
    <dbReference type="OMA" id="HEELQIV"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41622" checksum="D34E711E3DC11A96" modified="2023-02-22" version="1">MAPMNKSSDIGMEMFDQSKQSNKNAVFWRWFVAGTLLNLCITSVLVGLTVFYVHTELQSVKQRIASNEERLSLVEKAMPQENNDPTSTNTQLRIRRDQMPVSHNADQNLTLPFRRDIGPFEYGGCRDGRDGRDGRDGIQGPAGQQGPQGVKGEPGLPGAAGIRGPPGKAGPRGLKGDSEDTEPSDHRDNIRVSGGETFIRWGRTICPNHTGTELVYAGFATGAHYTHKGGSVDFICLPTDPDWAASYNDGVNSQSYLYGTEYELGFDPFSHENAEVLHNHDMPCAVCRLVDRGTQYLFPAKLGCPENWREEYRGFLMSGHYAHEQRSKAVCVDQAPEVVSGSHTDHNGALLYIIEGACGSLHCPPYVNGREITCTVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD61</accession>
    <name>A0A914BD61_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Syndecan</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073780.1">
        <property type="nucleotide sequence ID" value="XM_038217852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217852.1">
        <property type="protein sequence ID" value="XP_038073780.1"/>
        <property type="gene ID" value="LOC119741907"/>
    </dbReference>
    <dbReference type="GeneID" id="119741907"/>
    <dbReference type="OMA" id="RWSEIVI"/>
    <dbReference type="OrthoDB" id="10404404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037263682" description="Syndecan" evidence="2">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30087" checksum="3AF7532B62B2DCFC" modified="2023-02-22" version="1">MSCNRRTVFLSVMMVWVQGCLAGPLREGSGAFTALKSEKVTITTDTLAYFADQEGSGYSEVSEFSSSSGTNPIYVQMSSMEPSVEEALSSSIYNVHHESDAGTGDSDIVFAESESDTEESIPEDPTMAESDLYELDREENQVGQGVGEEFESQGEGVELDGNEVNGIQPTVTSVTSTSSPGDNSNVIPNGVLHHAPSNTSNDLNIVSSEHGNEVGGHKGHVNDIVDKEVKDENESDDMSGKPGSGIMAVVMFVTAIGVGALLSFMLVGLTKIGKKFFRKNPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDG9</accession>
    <name>A0A914BDG9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073895.1">
        <property type="nucleotide sequence ID" value="XM_038217967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217967.1">
        <property type="protein sequence ID" value="XP_038073895.1"/>
        <property type="gene ID" value="LOC119741980"/>
    </dbReference>
    <dbReference type="GeneID" id="119741980"/>
    <dbReference type="OMA" id="RYFAICL"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="391" mass="44658" checksum="22941031292B910E" modified="2023-02-22" version="1">MATEKTSSIMLTTTGYTEALSSVMAMNGSNSSQPATPDYFIMDLQRVMFIVTCILCSMGLLCNGFIIVILIRFPNMKTLANNFILNLALADFFFMVTFLFLSHQLKTGRWVFGAFLCRIIVPYDAMTQFLVIDFVMIMSIDRYFAICLPIKSMNFRTLRNGRITSAVIWLVAMLSTLPLWIYTVHICQNGSCLCLAGVSSSHNPADNRWWNIYTIIIGFCVPLIIICICYLLILHQLLRNPMQDSKNSSRRAARRVAILVICIIIVFILCFLPFYVVQFVLSTLEETNNIIAMVYVVTWSLMYSHSIINPIVYTLVGENFRKNIGFIFCKRSRNTMYSRQSSMRTSSFHTRRTRNSLKSTNSNDPTGLRPHNGYYVHLDTGQHRGAREDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEJ0</accession>
    <name>A0A914BEJ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074494.1">
        <property type="nucleotide sequence ID" value="XM_038218566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218566.1">
        <property type="protein sequence ID" value="XP_038074494.1"/>
        <property type="gene ID" value="LOC119742548"/>
    </dbReference>
    <dbReference type="GeneID" id="119742548"/>
    <dbReference type="OMA" id="NICHFSA"/>
    <dbReference type="OrthoDB" id="546518at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70286" checksum="798CFABD9FB79B22" modified="2023-02-22" version="1">MAEGGVTDQVLDETQKELQECPICYTEYKDPRMLDCSHSFCLKCLQELRLTQNKDDKNIVCPLCRKETALTEAGVDMLPGGSKDVNQQEQTEGQGLKVMCQVCDEAENEAISRCVDCKHYLCQECQKAHNRFAALKSHKIVALTELPVESQEITGDTELKKVPKCREHPDEDLCLYCDSCEVLICNECTNFDHKESMHSHISVDEAFNKCKQEVHESVSKTEEYIKAFIAANPVSIKHSRYRLDKMLAKTYNQISQKAEKEIAKIRKKEKQLKKQARDIAMKRDKDFACAAIPQQTLSKVNEVMTTATCYEILESKKKMLWDLNEQVRVHKSLDINHGKSFLGFEESKEDGQLGTLLLEEKWERDKTFSEHVHGRDYLHTAAYSTSEIAVVCSDKLLTLDTTGNVISTKTYKPDKPNEPHDPNDIQNPTALAINKDDQLLILDNPAVKIFNKEYQLLHQFLPGKEAGVDGTPTCLAVDSNNLIAVGYKDKEQISLHNPDGPLVRTLPAPKVDTYLKFSNKGLIYTNYKEGLLMAVDLHGNKLFNQSFRDPSGLCCDDAGDIYLLASIKERNHVYKNICHFSADGKFIFSWNFGDHCDITYTLAHKLSCTGYDMRRYHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGI3</accession>
    <name>A0A914BGI3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075373.1">
        <property type="nucleotide sequence ID" value="XM_038219445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGI3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219445.1">
        <property type="protein sequence ID" value="XP_038075373.1"/>
        <property type="gene ID" value="LOC119743094"/>
    </dbReference>
    <dbReference type="GeneID" id="119743094"/>
    <dbReference type="OMA" id="FAHRCET"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036812099" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="50"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="19585" checksum="DCA03F6B4C2D1714" modified="2023-02-22" version="1">MAGILMKVGLILLILSPKWSLFVYMQATGKFAHRCETLQVGACPEGWTARGNHCYKTLDGIHSYAAATTTACTDIGGWLPTPNTPEENAFILSMSVPTAEGVWLNCNDLETEGAWTCLDGGKQVRDRYWGTGEPNNAAGNENCAVIEHNDGRWHDVYCNYKHYSVVCKRSAPGVLSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BGV3</accession>
    <name>A0A914BGV3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075120.1">
        <property type="nucleotide sequence ID" value="XM_038219192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BGV3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219192.1">
        <property type="protein sequence ID" value="XP_038075120.1"/>
        <property type="gene ID" value="LOC119742926"/>
    </dbReference>
    <dbReference type="GeneID" id="119742926"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="218" mass="24639" checksum="7148B8DE025490B7" modified="2023-02-22" version="1">MLSRSQQMRPSLWMLFPMKMRRTNPKLNEYKAVITATEVFEASLRKTGFIAETASPLLTYARDVNVHCANKKCQELIVEARKLMKRELHNTKRVGTMKVDNKNLKDQKQDAKDKCHVSEGIFALPECAVSESIECLVNLAYQTLQEAGSNTPQCAIQLFYTVRNMFEIFCDVVPTYHRDSLQKLSLECALHHNNCMYIVPSPADAGPSVSSILTPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH33</accession>
    <name>A0A914BH33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074742.1">
        <property type="nucleotide sequence ID" value="XM_038218814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218814.1">
        <property type="protein sequence ID" value="XP_038074742.1"/>
        <property type="gene ID" value="LOC119742663"/>
    </dbReference>
    <dbReference type="GeneID" id="119742663"/>
    <dbReference type="CTD" id="740"/>
    <dbReference type="OMA" id="HPIATHV"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L49, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="22943" checksum="C84C9D446A9AAF8B" modified="2023-02-22" version="1">MALSTRSTVLSFLIIKNSIKLRTVSSTARPCIHSLLKRSISTSCPRLDSFPPNFYHPKDLVREEDARTEYIESKEDFKYVERLIPSLEPPTPPAHEKYPTPSGWAPPKGAVPGTPYTVRRTRYHSIPVYLKLKFGNTQQLTVIKNIEGDIWALAEELKTHLERLEGCTLPMRVSEFGRWVHFKGMFRDEVKQWLVEKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI83</accession>
    <name>A0A914BI83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038075142.1">
        <property type="nucleotide sequence ID" value="XM_038219214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219214.1">
        <property type="protein sequence ID" value="XP_038075142.1"/>
        <property type="gene ID" value="LOC119742942"/>
    </dbReference>
    <dbReference type="GeneID" id="119742942"/>
    <dbReference type="OMA" id="HERFHCF"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="21">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="20">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="19">
        <location>
            <begin position="359"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="50443" checksum="97B8782F8C0D0030" modified="2023-02-22" version="1">MEKQHKAALRTNRVALVQDMDLVYVFDGLVERNIFEPADYEDFKADGKASRKINQRFLNALERRGPKAFRAFVDSLREHNHGALANKLQQALATQNPEQMESRPGRVEDSPTGAISGPQGDSQLEIDAEPTTLVMASPTEESQEVPWPGNSSADLTQKKMRISPPPPAVQDASDVDGVYQMKSKPRGIAIIINNKNFEKMPTRNGTDIDGRNLKHVFEELGFMTEYRKNQTRKQMQQILNQAASRNHERFHCFILAILSHGEEGAIYSTDERIVKIEDITSYFEGGRCPTLAGKPKLFFLQACRGESKDRGHEATDSKAVAPGYAYGTQDSVAPISDEELVQRMLEQQLQDDTDAPTANRSKLPSHSDMLLAFATVPGFVSWRHGKRGAWFVQALSEVFLEHAHAKDLMSMMIMVNDKVACAFESSSGRYKQIPAPVTMLRKKLYFNPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLG6</accession>
    <name>A0A914BLG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038077133.1">
        <property type="nucleotide sequence ID" value="XM_038221205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221205.1">
        <property type="protein sequence ID" value="XP_038077133.1"/>
        <property type="gene ID" value="LOC119744981"/>
    </dbReference>
    <dbReference type="GeneID" id="119744981"/>
    <dbReference type="OMA" id="THYIVDD"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="54395" checksum="83B6F3963CB5B60E" modified="2023-02-22" version="1">MSDRETRLRLRLRDIGVCRGESHLEPSSREDKQCCGSLSPLRIKSSTGYKPDITWWQVYRPSARIPRRGTREQHQTCILDKTHIQLGVPETNTVAVCQACNQLQVLGIRARIPGGTMYLTSRHIKQLGLVVTGLCMTVFLLLFTYTNQRKIKGAQTDVGHKTAQHRLEGALSILHGTRQTEMNKQSKDEFLAAQAVIQQERLRQVKVGCQTMSNSTQTVASFEDLSKEALTHYIVDDTHRLLYCNIPKVASTSWLRIFLALKGVLANAYDGDQQFVQKDAASSLRLLSSYGRHEMETILRTYTKFVFVRNPFTRILSAFRNKLDPKLSHEGHRLWSGWIKRIKTHIRNGSSSATELTYDLTFPDFVRFVTDRRSMSNRHWTSMVHRCRPCHINYTFIGKIETINADSRSILQLAKIDKLVSFPDAQGSSPTNSSTSKVMASYFADLSVTDIQRLHKRYKWDFKLFGYDTPKYELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN87</accession>
    <name>A0A914BN87_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077191.1">
        <property type="nucleotide sequence ID" value="XM_038221263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221263.1">
        <property type="protein sequence ID" value="XP_038077191.1"/>
        <property type="gene ID" value="LOC119745009"/>
    </dbReference>
    <dbReference type="GeneID" id="119745009"/>
    <dbReference type="OMA" id="GKTRVWD"/>
    <dbReference type="OrthoDB" id="10063408at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="589" mass="66161" checksum="AC34F3F40BE511AC" modified="2023-02-22" version="1">MTDMSECNEDVASTQLGPHEVPNPEGSPNAQDVYGNVPKRQRMDGNESNSSEQNSQFVSSSNAQLSTDAEQTSSQASSQWQQWRSLFKDIFIETQKPTQTQCLACGDGEGDLVRCLDCGPGVTRCIDCTLSYHKESHLLHKPELVLETGVSPFPLRSRFERKNHQCFTTHTKSIQIFDEKGRLHNCWFTSCACEAPSATLLRWNLWPATPEKPRLAFHEELLRWFESLLAEGLSLRAASEAVRRRNSLKTQEADILYRNLKSGCFEEYKFFRRHCANLGSEPSTVKNGSMYVASPKSSVSELRRESHVPSSESMNEDRMTRSDSHTTLQGPISTVTGIEPQFRVGSPGSSDPSSIEEAVRSGVSVDQNCQEWKVEPLDGDDDSEAEYILVPVNEASAPNQNGLDVKPILFPAYGNGSNQAGQIIPFPGMPPRADQDLNHFDNLGSSDVAVMPTANIGKTRVWDKRQYCLYCRESFAKLPRHLRHAHRDEPDVIFLSRTQCPITQRRLLSKLRNLGNHLQNSDVLRQGTGKLIVVKRPSPGETVARTAADYQPCPYCFGYYVLRDQTKHNCHLKNFRAESALWLNLTLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNW9</accession>
    <name>A0A914BNW9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-mannosyltransferase DPY19L3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077650.1">
        <property type="nucleotide sequence ID" value="XM_038221722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221722.1">
        <property type="protein sequence ID" value="XP_038077650.1"/>
        <property type="gene ID" value="LOC119745401"/>
    </dbReference>
    <dbReference type="GeneID" id="119745401"/>
    <dbReference type="CTD" id="147991"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF3">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="88908" checksum="ADBF250F1A923917" modified="2023-02-22" version="1">MADDKTRLRKANPDSTATGDSVPSPKPYSLKDMETNSQEGAQEDAPPRERNRPRLKRRYTSKEESSTDSAYNSSDDEEPDITAEDGTTLRWFFAWATFLVGVSVAGLLGYAFAMYLITLHENRLWFSSIMEVEREISFRTEAGFYYSFYKQLVFAPSITEGLHGLTHDNDTENWRTINALERFNIYQEVVLAIIYKSLSFIQKSYPPIFFYIYSVFALHGLYLVALYCTAWMLSGSWLAGVLASAFYVFNKEDTTRVDYTIPLRESFALPMLFTQMAFITYYLRPNITVIRQRVSLAFILLSSFLFVLFWQFAQFVFLLQAMALYGSASLQMVPTHKVVRLLLLQAISILAVCLLQFFNKMLLGSLVFSFIAAALLDLQLQGNRPSPGGILTRFIKLLVHVVLVLFLMVLINMSIKFAIGLEADQHIFKFLTAKFGIANIRDFDALMYQCNGAFGFLPIDTIWRLNWRLVFPLYSVVIVGLLAALATAVYQNWSNQAALARAKKDDDATPPPPDASDSAHLLSERPELAYLAIQSVFLACLAVAIQRLKYLWLPHVCVLAAFGICDYRTWRALLTRLGFKSETGVQIARHVATLIVLAVFLTISLPRVYAELEELREFYDPDTVELMNWIREQTPKAAVFSGSMQLLAGVKLCTGRKLTNHPHYEDKELRERTLQLYQYYGRQPPNEVYDIHKAMGTDYIILEDSICYARAAAPGCRLPDLIDITNGHVYNGAKAEELKLLVEAKVGRFCDIIKRQTPEYMRYFHLIFHNKTFRVYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPG7</accession>
    <name>A0A914BPG7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038077596.1">
        <property type="nucleotide sequence ID" value="XM_038221668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221668.1">
        <property type="protein sequence ID" value="XP_038077596.1"/>
        <property type="gene ID" value="LOC119745361"/>
    </dbReference>
    <dbReference type="GeneID" id="119745361"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000106">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="92"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="449" mass="49806" checksum="93A2E0FBE4E9321F" modified="2023-02-22" version="1">MSNSTIRFLKLYNYIGWLNICNHGNRTRNFPKAFITSIDSKKSHHQAELSLRRGLHSSVSSLASESRGSKLVLGIETSCDETGAAVVDEEGKVLGEGLYSQKRIHVKNGGVIPTLAQDLHRQHIDSVVQQALRNAGIQLKDVSALATTTMPGLALCLQVGLQYSKDLLRRLPLPFIPVHHMIAHALTIRMIEKIEFPYLVLLVSGGHCLLAVARGVDDFLLLGSTLDNAPGEAFDKVARRLKLHLHPACHGLSGGQAIERLSLGGNIRLLMDKERPLLKHRDCSFSFSGLKTFANWLIYNHEVKEGISREDDLLLSTIPDIAASFQHKVAHHMVTRVARAMEFCRQRDMLAGTSKSLVVSGGVASNAYIRSALQFVCDKHGYQLHCPPPRLCTDNGIMIAWAGMEKFKLGLGIVEDLQSVRYEPKYPIGMDISDQVRAADIKIKRVKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSL1</accession>
    <name>A0A914BSL1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lectin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tectonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079169.1">
        <property type="nucleotide sequence ID" value="XM_038223241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223241.1">
        <property type="protein sequence ID" value="XP_038079169.1"/>
        <property type="gene ID" value="LOC119746349"/>
    </dbReference>
    <dbReference type="GeneID" id="119746349"/>
    <dbReference type="OMA" id="CEPWELI"/>
    <dbReference type="OrthoDB" id="166585at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF3">
        <property type="entry name" value="FISH-EGG LECTIN-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037230420" description="Lectin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30419" checksum="B6C621BD55866B1B" modified="2023-02-22" version="1">MPPNIYCLMWVLYVTSCAMGQSDAVDICAVEATPWKRFEGTLVHVSVGQAGVWGVDANKLIFYKDPAYGEDPNSCEPWELITGSLKQLDAGKDVVWGVTSRDHIYYRQGITPSAPKGTQWVRVPGLLKHVSVSQRGHVWGVNSNDNIFHRIGASNCNRAGDSWRQISGGLKQISVGSSGVWGVNSGDNIYYRDGTHGDPKSDPDGSGWTQVPGALKYISSADKVFGVNANDAIFYRAGVSAAAPIGNAWRNIPGGLEQIETLSCAVWGVNGNNEIYVKDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTT2</accession>
    <name>A0A914BTT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Espin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Stereocilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079141.1">
        <property type="nucleotide sequence ID" value="XM_038223213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223213.1">
        <property type="protein sequence ID" value="XP_038079141.1"/>
        <property type="gene ID" value="LOC119746329"/>
    </dbReference>
    <dbReference type="GeneID" id="119746329"/>
    <dbReference type="OMA" id="RANDGMQ"/>
    <dbReference type="OrthoDB" id="10261302at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1009">Hearing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="95218" checksum="0F645DBCB1F42901" modified="2023-02-22" version="1">MSVDQTLLAVRTGQLSAVKRAMARGELDRSLRDPYGATCLHLAARSGNLDLVRFLVEEAGHSTIATAQNGALPSHDSAAAGHQSCLDYLLRWGCPDQARDHSGATVLHLSARFGHLNVLRYLVEVRGLSIRDKDKKGVSVLHYASAKGDLSCLMYILTTVPDMVNERTESGATPAYFAVQNGHLSCLQHLVTAAGANVHLRANDGMQPIHAAAQTGQLHCLIWLVQDQGVLPMERDNDGATPLHFAASRGHAGVVRWLLDNGAVCERDHLGGTPLHDAAEHGQLECAKILVEHGCDVNSEDKDFLVASDLAKKCGHFHVAKFLRSIEKRTGKAKGKGQSGHTPSDHEAGVYVKHSVSSPTNTSSSLSSSALSDHDSLSSVGTIEREFVDPPGRYQVIDSPEPTPDPQYVQIYEKLTDVGPTTFQVNGFRATHKTAASPEGRGSRNGSEGLSIPKKVTEVCSQGTQTECPEPRVENGAEDGLENGKSQWESDHKGAATTPPVVSPKKSIRRQSATEQSVISSSRREAWIETNHAAVAGRPPRALKPSPDKKALRFSTTVMVEEIAQQEEEENPVSPTKRNVQLIPLNMSSEARLQSPPPRKSSDLDDVPSPPSITNSPPSYLPTVRPSRPTAIVIPPPPMMASPPTSLQNREDNLDKLREVSSRLSFITSAVLTPLSPPPPPPPQLANGLPQHSPTTSLSLQLAPSVPGPPSPSDLASVVLKPSPQNSRPSSSNSSKGGKLNGFGTDLLAEIQAGAQLRQARQNQSRFLRINKDPPPRSPSPVNDKGPRVFYAADFLDSIPLVDESGAELPDWRRRFLAKKEADRANQRAAMEYRQQKQQRAEERKYRDMPPWKVELLKKKEAKYMGVSDTSWQNGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU19</accession>
    <name>A0A914BU19_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079361.1">
        <property type="nucleotide sequence ID" value="XM_038223433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BU19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223433.1">
        <property type="protein sequence ID" value="XP_038079361.1"/>
        <property type="gene ID" value="LOC119746471"/>
    </dbReference>
    <dbReference type="GeneID" id="119746471"/>
    <dbReference type="OMA" id="NFINERH"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117255" checksum="3B57D1C3BA7195CB" modified="2023-02-22" version="1">MADPLFPAKRSIFVKTYSKIRPLQTFDPDPLKSFKNTCGATPILRTGKPFPFIQPANSIAPTLAPANSPSSDTSSSETPDVEMISNEVEKKLDTEEEDEKSFITLTPTSKKTSKKQSKKKSYSPLKNISNVIKVMHPRKTAPKRVVSPFMWTSTKLRPQGQLASIQESDQESVSSDDQECTNDAKDESKGTASNRKPDRISNLPKGPHHTKKLVSQDIQTGAQGIPLHSQKRSKDSPMMVEGRGVFTSSYSSTMTDQRSTQMYGSQTDDEDDMSTVTYTRQSGETSDESTMVISDVATDDNDSMTTATVKEEEFSDIEIPRDFPGTTTRVMQQLTPTVANLVLPEASERKTLRKTTVSTAKAMPKKRSSVWSNRKPTVKTKNSTLVDGLTALNIQQYEPIEEISDIKEDNSRGDLDPNKKTSTPSSKGRNTMLHQRFIPDVSSIEGDACAMPTIDVMQSLTSTTLADKMKSSSTQKLAELRPVTAPSETKGPAPRSVYSISASSDDDLPTPLGIRGRKAFTIERASPRMSPRLSFGQYPKAATKMISNSQKKTSVVSAGNLSRNDSSSNKHVKFLLSNKAHEVLPEPDPSRSLSIVNLPELPLSSSILKKRETMTGERRTSFASKIEEHTKQSSKQEKQQTGRTRMTSTPQKHSRRSKGAHMLALSFDVSSVDLPSCSDDDVITQPSNHQTESKTTAVVTDREAEEEETITAAGQSTQELMDFEPIPMQASTSINSQPLHLSQVIQEDTRPANLESQLSDNATKHLALATQRATSNPEAIQHPAPATQRYRQAQHPSIATPQQNACQRAEHPVRATDDQRCHRLQEAKKSLRFIQATPSMRASHQEAQNLVQGTQHPLQGTHDEFNPQGDFHPVSGTDDLCSPNGPDIESQQETEYPAPDKDDMCVPQGAENPVYGTHDQLSPRNTQYPDDSTLGTKEAEHPIHATPKSQLKRSSPNGDLPGRPNKKKFLKKDASDEIMVTTPQTCDRATQKDFPRQQKRLDYVDKAVGLPECIFSQLGPTPYRPAKFRQYIDTVNVMDYDKIKNLPQDIFETIPDAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU71</accession>
    <name>A0A914BU71_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038079442.1">
        <property type="nucleotide sequence ID" value="XM_038223514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BU71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223514.1">
        <property type="protein sequence ID" value="XP_038079442.1"/>
        <property type="gene ID" value="LOC119746533"/>
    </dbReference>
    <dbReference type="GeneID" id="119746533"/>
    <dbReference type="OMA" id="TENAGHI"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="263" mass="30172" checksum="EEE138C4D07F843F" modified="2023-02-22" version="1">MLFRSFQGPHNWYKAFPKCAGKNQSPIEINEKDTTRVNLGNLKLEGFFKNDKTSISRWGVANDGLKVYINLEGTYYISKGGLEGRHKAYNLYFNWGRVDGRGSEHKLDGKFYDGEIQIVSYSMSAQKQSGFVTMIKVVEKDNPLLKELINAVKKVKYRGEATNVPTLDNLADLLSPDFGNFYRYEGSRTWPECTTGVTWTVWRTPLEMGRAQMEEFRGLYNKEKGTADNIHIADTVRPLQPRDGRKIEYNSQHNYRTDVEASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4G2</accession>
    <name>A0A913Z4G2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation channel sperm-associated auxiliary subunit beta 2nd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046723.1">
        <property type="nucleotide sequence ID" value="XM_038190795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4G2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190795.1">
        <property type="protein sequence ID" value="XP_038046723.1"/>
        <property type="gene ID" value="LOC119720929"/>
    </dbReference>
    <dbReference type="GeneID" id="119720929"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028748">
        <property type="entry name" value="CATSPERB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048788">
        <property type="entry name" value="CATSPERB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705:SF0">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21548">
        <property type="entry name" value="CATSPERB_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel sperm-associated auxiliary subunit beta 2nd" evidence="1">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="282" mass="31134" checksum="A0C7A4E7F0F36BE5" modified="2023-02-22" version="1">MSNPSLLSDVTKLHLASSPCSPDITVLGLGYNTTKTQGIILGVTTDAFRSDSNSTHWYNVTNQLCQVITPSGCEEMTLIDLILTADQSLLLLTTHGLFLGQLPATDPPVSRGTSLQHQVSWSLVELPSSIVFASFHLSYTPVCYNSYSKSSTEQVAYVAMVNSNEVVYASYPTYTNWTVSPSNSPFSQPTDLVYDHHTDSFVILQKKEGNYSVIAFSSDQLFQVGTVNRSRFPAFDEFPSTFHPAQGKALCFSPATHEVFVYGNQVSGRIFVIWGFWRGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z599</accession>
    <name>A0A913Z599_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046998.1">
        <property type="nucleotide sequence ID" value="XM_038191070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z599"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191070.1">
        <property type="protein sequence ID" value="XP_038046998.1"/>
        <property type="gene ID" value="LOC119721174"/>
    </dbReference>
    <dbReference type="GeneID" id="119721174"/>
    <dbReference type="OMA" id="INCTEAY"/>
    <dbReference type="OrthoDB" id="10026631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000185">
        <property type="entry name" value="basement membrane-specific heparan sulfate proteoglycan core protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000294">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038126824" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="485"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="609"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="664"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="739"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="776"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="821"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="875"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1272" mass="134501" checksum="B5FD331829257871" modified="2023-02-22" version="1">MKYNQLLIIIISSSLAHRTYATYCTSDPCENGGTCFTGESSYLCVCPTRYTGQNCETYIDETDYSTTPCTSSTCYNGGICYTGPNGSYYCKCASGFGGTNCEIAEDTVVANTTDPGSVTSCTSSTCHNGATCYTGISSNSFFCLCPSGYAGVQCDRVTATVPPLAVRYCASEPCENNGTCYTGQSGYICLCLAGFTGQHCETKLLCNSNPCQNGGTCFTGQSSYKCVCPGSFTGEDCETPASCTDVPCENGGSCTPVGGNTADMVCTCPNDFYGVQCEHHVDICSSSSPCLNGGTCFTSSQNQTAFICSCLSGFEGNLCERSNPCANNPCLNGGVCSHPLDPTNDMIMCQCSNGFVGQRCEIMDTGVGACVTGVCMNGGTCIPSPFAAGGLTCLCPASHTGTRCEQQNPCNSSPCQNGGSCIPTSNGTSYQCECPEDFVGINCDVPVPLACGSDPCLHGAACIDVGDGNYRCACLEGYTGRRCEVIGPCVSSPCMNGGLCVEVVYNPGNFVCHCSNQYTGPTCTIPPQEDPCNSSPCQNGGSCIPTSNGTSYQCECPEDFVGINCDVPDPCSPSPCLNSGVCNAIPAAGGTWGFYCVCTGQYLGLTCSVQRACVSNPCLNGGQCVDVPESAGQPIYGTELHSGMLHYNCRCLDGWTGQNCETQITDPCQSLPCKNNGTCFRSHSTNRFFCSCPEGFYGQLCVADPCAANPCKNNATCQSTGNEYTCICATGYSGVDCTVEDPCHTNPCTNGGTCTLTDTWFECSCAPGYIGSDCSQQDPCFENPCLNGGNCMKRGAGNTLDYQCLCPLGYGGLTCGVYFGEVNKCVLNLCENGGSCYQGSASSAGAYICVCAQGYQGRNCNELVLAAPLSATRSSSNPCEPDPCQNGGRCFQGSNSTSYLCVCPEGFIGDHCQSPNTTAVPTTGVPMTAAPMTAAPGCVYSSQTYMDGETWQDGCKDCMCSGSEYSCTTERCQCTSGSRIYNNGESWEVGCLFCSCLNGQASCSDMNCANRCLHESRLYDPGQTRTDNCNMCTCNAAVWTCTNNPCGKTCTYMGRVYLANENRKDDCNTCSCIEGQWGCTERTCDAAPIVIQVEFDFTNDFSSVAGKEEQFTTALKANLMQLLRVRESHIQNLTISAGSIKVRFNLVENKTNNVDIETVAVVLETSISKNSYTFIFDNQQYESDPASFRIVRQGTPTPTPGPESNSLIIIIVVVTCGVAGILIVIGSVCWMVKRHSTTRGITEYGDDRLPSHNPSFDFDNGGDDYQNSISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5L6</accession>
    <name>A0A913Z5L6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038047096.1">
        <property type="nucleotide sequence ID" value="XM_038191168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047097.1">
        <property type="nucleotide sequence ID" value="XM_038191169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047098.1">
        <property type="nucleotide sequence ID" value="XM_038191170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5L6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191168.1">
        <property type="protein sequence ID" value="XP_038047096.1"/>
        <property type="gene ID" value="LOC119721215"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191169.1">
        <property type="protein sequence ID" value="XP_038047097.1"/>
        <property type="gene ID" value="LOC119721215"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191170.1">
        <property type="protein sequence ID" value="XP_038047098.1"/>
        <property type="gene ID" value="LOC119721215"/>
    </dbReference>
    <dbReference type="GeneID" id="119721215"/>
    <dbReference type="OMA" id="WEETAGV"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="292" mass="32870" checksum="B2599FD012E0D40D" modified="2023-02-22" version="1">MHPLSENITTEAVAMPTKMSRSNSPPNNNGSAYMSGLKRKGSTVRRNGVAQAKPFKVIVLGQASVGKTAMTVRFVTRRFIYEYDPTLETIYKHRTFFETENAPVDFEILDTAGQEEKIEEKLKWADAFIIAYSINDRCSFEEVTRLKFLAGRCKKSSSHEQAILIVGNKKDLEYDRLVQREEGLELARSMNCSFVEVSARESYEDVVAVFERLYMDHKNRKRTSTNSPKFTLRRKTSVGSKQDLDSNPPRPRARSTSFAATTPVYTRRMALTGFDGGSGSPLGSDSCDTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7N1</accession>
    <name>A0A913Z7N1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Troponin T</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047732.1">
        <property type="nucleotide sequence ID" value="XM_038191804.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047737.1">
        <property type="nucleotide sequence ID" value="XM_038191809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7N1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191804.1">
        <property type="protein sequence ID" value="XP_038047732.1"/>
        <property type="gene ID" value="LOC119721862"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191809.1">
        <property type="protein sequence ID" value="XP_038047737.1"/>
        <property type="gene ID" value="LOC119721862"/>
    </dbReference>
    <dbReference type="GeneID" id="119721862"/>
    <dbReference type="OMA" id="TGYMQRT"/>
    <dbReference type="OrthoDB" id="330499at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32602" checksum="A5AB4060FD86EB0E" modified="2023-02-22" version="1">MAAPEGEEPDALAIIKEQAEKRREEVNKELHEAREEYRRMKEEKEKELETLRARRDERRKQQAEERKMLEKFAEERRAKEKEEMRKRKEMADMRKKEREARVRAMHDPNAFKAVIIEKEKPQKAPKKSKEELASEKEEAMKERIQPLHIGASTAEDKIREIARNLLQRLQAMYTEIFDMKVRRKRQEYDHKELLQRIKDLTKVKEPVAAESAGTVHKFKAGGVFKPQDEHEQNKSKMDREKEAGSIISSGGVAGRMGMFGGSSAKKAPGLERGPTIDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9M6</accession>
    <name>A0A913Z9M6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047590.1">
        <property type="nucleotide sequence ID" value="XM_038191662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9M6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191662.1">
        <property type="protein sequence ID" value="XP_038047590.1"/>
        <property type="gene ID" value="LOC119721584"/>
    </dbReference>
    <dbReference type="GeneID" id="119721584"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="140" mass="15924" checksum="9C9A4FA69C7712EF" modified="2023-02-22" version="1">MYYDSPSSWVDAFKFCDSKRSHLAVPNSQAEIEFLWRMVLAMETVKRRGVWIGCKRESADSSFECAGNTEGMSFTNWAPGYPEQGAPRCVVMSKGLGTWKTNNCARPSYYKYVVCEMPNTPRVHCLKANANGHFVDDYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9R4</accession>
    <name>A0A913Z9R4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048522.1">
        <property type="nucleotide sequence ID" value="XM_038192594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048523.1">
        <property type="nucleotide sequence ID" value="XM_038192595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192594.1">
        <property type="protein sequence ID" value="XP_038048522.1"/>
        <property type="gene ID" value="LOC119722462"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192595.1">
        <property type="protein sequence ID" value="XP_038048523.1"/>
        <property type="gene ID" value="LOC119722462"/>
    </dbReference>
    <dbReference type="GeneID" id="119722462"/>
    <dbReference type="OMA" id="TKEANTW"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23965">
        <property type="entry name" value="GT29_ST6GALNAC3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23136:SF12">
        <property type="entry name" value="ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23136">
        <property type="entry name" value="TAX1-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="525" mass="59546" checksum="A84CE07FD0FC984B" modified="2023-02-22" version="1">MRLCRTRLGTWGRRKVLMMAFWYFAVIFSAFLYYTYATWRPANMYSALFDVPVAGDHRAGAALLEESPDVLRSQRAELRRILGENVSLAGRKSSEGDTRARARDPASADPQLPFPGGDSSILGLPNKSSRIVRGSGVAANRTRNASAPGGSNQDHVTNENSLRRRVETENEVELTEIDTEEEEDDDEVRYPVTYSLDLTTVGFENATLKPPLAPAVEGYERVSSAEALRLHCGRCSVVSSSGHLINQSRGRDIDSAQCVLRMNSAPTVGYEDDVGARTTVRVIGHVNLLVLNSSREYQHEIFVNRTSRADKIVIPWLHSIRLNKETNLYYKIAQNFSKTFPEVEFYFLTPEKSKMAEEIFKSETGLTTREANTWLTTGWMTLLFAIDVCDEIDIYGLVDEGHCRDHPNDTTPYHYYDPSGMIECKYYQKSEERLTGGHLFITEKAVFARWAHRFNFRFHAPAWNLTANPAANLSLALETPFLKMFYEAKRNNRSVAAVRTRKVVRRIVRRVVIKRKVPVLKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAK6</accession>
    <name>A0A913ZAK6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047935.1">
        <property type="nucleotide sequence ID" value="XM_038192007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192007.1">
        <property type="protein sequence ID" value="XP_038047935.1"/>
        <property type="gene ID" value="LOC119722025"/>
    </dbReference>
    <dbReference type="GeneID" id="119722025"/>
    <dbReference type="OMA" id="GLHQTMT"/>
    <dbReference type="OrthoDB" id="416618at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF14">
        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="815" mass="91428" checksum="2A7FE2E79C8200B2" modified="2023-02-22" version="1">MATIKMGLIGSRPTLKRYSLIVQVGVGLLFLAGHWTPVYSQSQTYQGLVSEGKHFSELVYVSPHNASEAIRVTASSQNADTTYPVLFVVRQQKSVLSWAVPFIIQSMYVYDEVSHTLCPENGFSPTAAHNISIDVTTASVKPVNFTLTVTMMDDFELRTHVPKTVVVSPSNPKYYVYKFPDDADFMTVQATSTSEICTVISVQPAQCPVYDQHRNVEFVGQFQTVTKQGAITVQKKKYPSGYFFVVAVVQPTDKDCLGQTIEYVPLQNMSSQDVLEIAKNRSKEITISVDTILPLSEYWKPIVATVGVLLVFYVIAGIIILVQCKRRKEQHSEHLEEQVHILGEEENSNDVPFAQNQPAATSNYGTTGKDSGNSAVRSRPLNKLSTNEADPDEDDIDMLEDMNEEKEIYRTKMSVCVADLARKKPKTLDRKYKLYYWNILTIAVFYSLPAVQLVMTYQAVLNMSGNEDMCYYNFLCAMPCGLLSAFNNVFSNIGYVMLGFLYLLIVSRKHHIHKQAVASGCEKSKTCGIPKHFGMFYALGIALVMEGVLSGSYHVCPNYSNFQFDTAFMYIIAGLGMLVLYQQRHPDVNANAYAAFATFAAVIFIAFMGVVFVSVYFYVVFAVLHIITCLAVSAQMYYMGTWKIDLGMFKRAAIIFRTELCKCARPVYIDRMIVLIIGNAVNWSITIYGLVKMPKDFNSYLLAIFLVNLLLYVAFYIIMKVRNGEKLIPAVVVIIILALVIWGLALNFYFMGLTGWEKTAALSRESNAPCLVMGFYDGHDVWHILSAAALFLSFLLVLLMDEDLEGKDRTKIPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBC5</accession>
    <name>A0A913ZBC5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048195.1">
        <property type="nucleotide sequence ID" value="XM_038192267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBC5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192267.1">
        <property type="protein sequence ID" value="XP_038048195.1"/>
        <property type="gene ID" value="LOC119722221"/>
    </dbReference>
    <dbReference type="GeneID" id="119722221"/>
    <dbReference type="OrthoDB" id="9015981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="380" mass="42455" checksum="01C66A852BECE3F6" modified="2023-02-22" version="1">MGAGITSGQCNEQDTVNISQEAVSSWLHTRLDICIKAIVVPIIWCLGIITNLTFLFVTVRVRKLRSDTNIYLAHLSLADLLYLSLESIYDIRSYTASVVAFHDPFVNSASCVSFFTVINTGYFASIALVTMVSFERFLALCHPIKHLKIRGRRRTHRMIAICWLVGLLFSASTVPRVLVLNVVCLQWPNVDAFVDYPSSHAYCGPVSPWLNYFIPPLLNIPWIMAVVANVFMYVRILQMLNKRHSNKNITVKKDHNATHIRSHVAKMLVANGTVFFLCQAPYRIFSLSGWICLLAQIPDPFRAALGSGTIWISVVPQNINAMINPLIYGAVNPAYRSAIKVAFKCKGQASRQNASPSVIRAPEVNNTTSLAIDENIETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEU9</accession>
    <name>A0A913ZEU9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049994.1">
        <property type="nucleotide sequence ID" value="XM_038194066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194066.1">
        <property type="protein sequence ID" value="XP_038049994.1"/>
        <property type="gene ID" value="LOC119723426"/>
    </dbReference>
    <dbReference type="GeneID" id="119723426"/>
    <dbReference type="OMA" id="HAQKETH"/>
    <dbReference type="OrthoDB" id="5965607at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="628" mass="69858" checksum="D7A5658441868F39" modified="2023-02-22" version="1">MNKNLMNMDGMKRAAKKMLRGGGDLGSVVMDEKTLQGDVSGKLIPSINNVAMGLLKWSYAESNYTFPDVFSAWADLDVGFTQLLQEYLEECTRYRKSFKAIITEAKKVSDLQKEKERTASKVSTTSSKLEAAKKTAKKNENNEKAKVHVSSAEAELYQARAKDEETEELLRNTTADFECYKATMLKDSLITHCQSLQALLQKGTALCQVKMEIAESMPDEPAMTPDAGNNNNRKVEAIFNKYHLQLPQRDPTVERNLPAQRFKTLPPPLSSYPPTSPRITKQTSLPVKTPPARYPRPLGDILDVESEEGEDDDDYMVPSEDITSRPTVKTTPPELPPRNVAEEEDYVVPTLSPKSPMGNKVQPPSSPGDMEADYFQVISDDEKDGNFSSTPRKPSNPRRRQDDRNAPEPVSEPVYTVPPDENEDNTDSGQLYGNMSNEELEEHNRTSVCIPVKPTPYGKPKKPAVYPKPALKPTKEAPSRRRQDSASKDEECAAEDDDIYSMVCEEENAPNKTGVSPRTPSQRHVFLDSDQPGHDRQTRHTYFNAELSHQDSFDSAGESDNTDVSHTYFNVRIGDKEMNGSDPTLYGNVPPVPDQTAPTSNSKPTPPVAKKPAVLPRKTLHPVQGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGV2</accession>
    <name>A0A913ZGV2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050245.1">
        <property type="nucleotide sequence ID" value="XM_038194317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194317.1">
        <property type="protein sequence ID" value="XP_038050245.1"/>
        <property type="gene ID" value="LOC119723590"/>
    </dbReference>
    <dbReference type="GeneID" id="119723590"/>
    <dbReference type="OMA" id="INGPIHE"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="27219" checksum="6E76456AF9466617" modified="2023-02-22" version="1">MEVAKRTQNLTSKRGGKEIVAEAFTIQSQMKNVKVQNPPKAGAFMEQPGKPTSFRKFYERGDFPIALEHDTKGNKIAWKIEIDKLDYHHYLPLFFDGLKETTHPYEFFARQGVHDLLEHGGNRIVSVIPQLIMPIKEALNLRNHKVICTTLKVLQHLVVSADLAGEALVPYYRQILPMLNTFKNQNLNIGDGIDYGQQKRENIGDLIQETLEALEKHGGEDAFINIKYMVPTYESSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHZ5</accession>
    <name>A0A913ZHZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050681.1">
        <property type="nucleotide sequence ID" value="XM_038194753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194753.1">
        <property type="protein sequence ID" value="XP_038050681.1"/>
        <property type="gene ID" value="LOC119723869"/>
    </dbReference>
    <dbReference type="GeneID" id="119723869"/>
    <dbReference type="OMA" id="ITECIFD"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="218"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="818" mass="91718" checksum="B4F2F5BE9E3ADB48" modified="2023-02-22" version="1">MVIPGKFGISSKMAEQEEMMPTQDAERQGQVADGDCAETQEQALALRRPGNQDQTTDMIPVAAVNQLQQSVQQISGSGHVPIFNPKDCTFNIYQSKDDAHASHHSGHPSVDISENPPSTSQQPTTSHVASGAQGCSAPKKMKLDSPAQDVADCCEDALKSHYRGKGSFVKVLPWVGDDRKHITEIYTKLQLILGKYKVMLTSYADILQRKTKEGDLILIAVLTGLAGRGKTTLFDKIAYDWAVGSSQVLRKYKLVFLLKMHALEQSSDLVDAVFDQLLAKDVCIERGALDMFIKKSPGKVLVLLDGFDELMTTSLCESSFGSILEILSGKMLRGCTVLVSTRPSHFHRLVSEELVQEPFTHVEVMGFSRKDVIEYVNKFHIGEPDKAKGLLNKIKSSGLLSDLAASPMLLLLMCVLWQEECTLPETMSRLYHDGFSYIFQRKGLDSQGKVAKVVIEIGKVALHGLLSPDQSLSFKESDFEPSVLELALKAGILTRQRVRKRLQSHNSVQFFHKTFQEFSAAAYLQNLLEADPEEFHKILNEIMSKGARRFEYLLRFCCGDNEACTYEIMKVFQVRYQEDLSFESEMGLLALHCFFEGQSKRLPPEEFIHSFITDEIHIRGLNRDCLNSVIYFVKCVAEQTKDSGNAYLSKVHKLHVHYCTWTWFIEELAVTMCAMTNLHLVDFNSNADISADKLLRHLPNLIHKLYLAGNNLGGTAALWCMHLKQLKSLTKLDLSYCSLNGQDMKHVAESLEDLPNLGELRLNGNDLGGTAALWCMEVKQLQHLQTLYLMGCHLTEEDKNHIDESLSNLKKNGLSIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIK6</accession>
    <name>A0A913ZIK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050875.1">
        <property type="nucleotide sequence ID" value="XM_038194947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194947.1">
        <property type="protein sequence ID" value="XP_038050875.1"/>
        <property type="gene ID" value="LOC119724025"/>
    </dbReference>
    <dbReference type="GeneID" id="119724025"/>
    <dbReference type="OMA" id="KCEVETR"/>
    <dbReference type="OrthoDB" id="6147913at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="26454" checksum="CCDAF86235A24627" modified="2023-02-22" version="1">MAKVRKPNFSEKEKLLLLSEWEKRQNILRPKFSSKITSQGKHNAWQEIADSLNAQFPSVRRDVADLQKKWQNMNSKMKEETSRHRKDSLKTGGGPAPPDLSPLDQRLVTLVGENTPSIIGINGGFDSLGLLSLPEEQPAVVIFFGKKTHATHVGGVPEPIISQQPRPIQSTTVPRKRRADMNDDEYGKLLVLEQKRSEAETRRAQVEIEKLELEKEMLCLQIAILQQQNFQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJD4</accession>
    <name>A0A913ZJD4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">adenylate cyclase</fullName>
            <ecNumber evidence="29">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="31">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="31">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="31">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29 32">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="29"/>
    <dbReference type="RefSeq" id="XP_038051898.1">
        <property type="nucleotide sequence ID" value="XM_038195970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJD4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195970.1">
        <property type="protein sequence ID" value="XP_038051898.1"/>
        <property type="gene ID" value="LOC119724764"/>
    </dbReference>
    <dbReference type="GeneID" id="119724764"/>
    <dbReference type="OMA" id="CVYMGLS"/>
    <dbReference type="OrthoDB" id="10261550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000006">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000009">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF30">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 29 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="22 29" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="25" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="27 29 32" id="KW-0456">Lyase</keyword>
    <keyword evidence="18 29 31" id="KW-0460">Magnesium</keyword>
    <keyword evidence="26 31" id="KW-0464">Manganese</keyword>
    <keyword evidence="24 29 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 29 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 29 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21 34" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="35">
        <location>
            <begin position="314"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="35">
        <location>
            <begin position="872"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <begin position="319"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <begin position="1004"/>
            <end position="1006"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <begin position="1011"/>
            <end position="1015"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1051"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121927" checksum="ED66F2EA5EEF7585" modified="2023-02-22" version="1">MRGKKSHLGGGETPIISGDLESYPELEMSTTDADIAKMKRRERRKSRLSVGDSCYQFLPAWLRYQFKSASMEATYQTYFTRQRRDALPVLAGFALLFDFVVLALYIFKSLSTAIAIMAITTVTNLIVFALCQYKLVTDWTLLHVMPYAVWCLLTGQTAVDLVFYYFPMSPSDGVGWQVFFIFASFVMLPIRLRYILVLSLFNVIVHSVMVGVMSTVHVSNLGAQLAANLMMYACSMIVGCIVFLMADRKQRRAFVETKAALEIKLTLQEQSTQQEELLLSVLPKHVADDMMEDMGTVNKGQFNRIYIQRHENVSILFADIVGFTAMSSKMSAKELVKTLNALFANFDKLAERHHQLRIKILGDCYYCICGVPEQRPDHAACCVQMGLDMVVAIAAVREKTQSGVDMRVGIHTGAVLAGVMGQQRWQFDVWSTAVVLANHMESGGIPGRVHISQDTFEFLNGEFEIEPGEGETRDDYIKDRGIKTYLIKVNKDSVQKAAAFNSIILSDDASTTKKSEEEESDEKAENANGKTVTFEAEGATESRPDEGITNRKLYEALVERETDAEKTSGMRRLTLWFQDKNLEETFHREKERQSPVGMGCAVIIMIFGFCVQLAVLPRTTTSYVTFGVGIFLVLLIFYTSMATSFRKRYPDVLISVASWMESTYVARTLIVTCVAVTVAASDIVDMVVCENTKNPITELDTQNPSCIYLRYYTYSGILVLVAITVMIQVTQFVKMLLIVIIGSAYALLNLLFYNDLFVRYDEYNKEQAELLAKEGQEEKDYYNDLPSRYIITYQLLAAGAALIFYNRFLETTNRLLFFWKYEARKQKEEVGKLRIRNEQLVLNIMPIHVAKHFLQSKRKDEDLYAQDYPEVGVMFASIPNFSEFYSEDAINNQGTECLRFLNEIISDFDTLLKAVRFRSICKIKTISSTYMASSGMVAEPEKIIYEGEQERWQHLADLVNFAFALRDTLDTINQQSFNNFIMKVGINHGPVLAGVIGARKPHYDIWGNTVNVASRMESTGKAGNIQVIEETMKVLKRFGFKFQQRGYVKVKGKGELLTFYLIGKEEKADVLPNMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJD6</accession>
    <name>A0A913ZJD6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051922.1">
        <property type="nucleotide sequence ID" value="XM_038195994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJD6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195994.1">
        <property type="protein sequence ID" value="XP_038051922.1"/>
        <property type="gene ID" value="LOC119724783"/>
    </dbReference>
    <dbReference type="GeneID" id="119724783"/>
    <dbReference type="OMA" id="LIWEDEC"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17403">
        <property type="entry name" value="MFS_SLCO4_OATP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF100">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="690" mass="74798" checksum="286D1D8355E58CEC" modified="2023-02-22" version="1">MNNSTGAMDDQNDRNEISNQAEVEMRNPNKRTPSISSKEEDANEDVECVPYGWLSIRPKWLQFLNNPKGYLVFLCWFVFVQGMAVNGFISVIISTLERRFVLPSVQSGSISSCYDFSVMIIIIFVTYLGESSHKPKWLGTGAFIFVLGSLVFMLPHFITPEYDVTPSEVDTCDPTRPTANTCLEGDSSLSNYFWMFVAAQALHGIGASPLFTLGVTYLDENVRPASLSIYIGIFQAVSTLGPAVGYLVGGLFLGIWTDFPKEPPGGIADDHPLWVGAWWLGSVMPACLGILMVLPLLGFPRYLKDHKKVAALRVVENQKGTDFKSRSETEGVAGGIKDFPVAVWTLVKNAPFMFICLGLITESMILSSISAFGPKLLESQFSVSSGSSAIIAGMVVIPSGLIGALIGGFLVKKFNLMFRGMILLCIATLSVSLVLMAGFFFNCPSLRFAGVNTYYNNTSLDYKGVFDLASQCNSNCSCDTSYNPVCGDNNIMYYSSCHAGCTEKLDKNADGYQTFSGCGCVSANETDARNGAVAGECSIDCGNLWGFIVVVFAMALFAFVAVVPTVTATIRCVSHTQRAFALGVQSLLYRALGTVPGPIIFGSIIDQSCILWETSCDGARQCWLYNNGEMSLNVFILLASLKLGSCIFYILCYMTYRAPSSAEEGKDSDVKMASDGKAEGAPVGTLSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLK1</accession>
    <name>A0A913ZLK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052657.1">
        <property type="nucleotide sequence ID" value="XM_038196729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196729.1">
        <property type="protein sequence ID" value="XP_038052657.1"/>
        <property type="gene ID" value="LOC119725335"/>
    </dbReference>
    <dbReference type="GeneID" id="119725335"/>
    <dbReference type="OMA" id="ADLIWHR"/>
    <dbReference type="OrthoDB" id="5829348at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="47268" checksum="E3698E198377A0FE" modified="2023-02-22" version="1">MGCGNSSETEGRKEEEHGFFHRRPKVSIRVGQHVEETSKDETLVVFVFGGPGSKKGRIVDDLVHMYGFRALIAEDLILKELPKKVQNVMTIESTRGLAEMLKDNQSLLSLEWILELIGNEIEKDPKRPHIIDIMPNLRFLLRCEKYIQDPEYDMKNFEKRFHNVFALNLAIPEEKVIKQITAHSAKHPDKMKEAGQSDEADTSRTQRRNALYTSSVKNFLNYFTSSGRLVTVDVACGVADLIWHRVSDFFGHQLELEPIRTVNTVIIFAFDELDFDGLDMDRYALQSVTLKNLVDDSKAPPDKVLAALCRHIDTSAPLVEAFAVDAADTTLLSYTSDRKSRSTRFVEHAETYLDKYIFISNLKKTRGRKCSLFQRLYKVVATTQNEVCLFPQETDTELCKRIALYMAEERKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNJ8</accession>
    <name>A0A913ZNJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038052621.1">
        <property type="nucleotide sequence ID" value="XM_038196693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196693.1">
        <property type="protein sequence ID" value="XP_038052621.1"/>
        <property type="gene ID" value="LOC119725313"/>
    </dbReference>
    <dbReference type="GeneID" id="119725313"/>
    <dbReference type="OMA" id="AMNDEYA"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="298" mass="34179" checksum="280EBDBD8AF88A1C" modified="2023-02-22" version="1">MADNLSLSEATQFLKGVLQMQSPMESLARDRVSFLRDLMAAFLSKIPFQSVTAIATPKPERRRLTFQEIKVDMITQKGGLCFEMNYFMKALLEKLGFEVYHVGCTIIGKPNNHLSTVVKNLSRPGDLHLVDVGCGHPMFEPIPLDFDKESPLYKSNYLVHKFVKDADDSFRWMHKSYRDYDGSTGRVVDGWYMFLEFKLEFRDIEFFALHMENIHTVESGPEALAHFLVQLKATDFRNGKLFAITGTSTLEEDASGKVNKKRISSPQELEEAYKFHFPQFPAETIQQAIQTVNLKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNT4</accession>
    <name>A0A913ZNT4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053039.1">
        <property type="nucleotide sequence ID" value="XM_038197111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197111.1">
        <property type="protein sequence ID" value="XP_038053039.1"/>
        <property type="gene ID" value="LOC119725632"/>
    </dbReference>
    <dbReference type="GeneID" id="119725632"/>
    <dbReference type="OMA" id="GANACCC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037723629" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="126" mass="13160" checksum="F1D9EF6F71F71E6E" modified="2023-02-22" version="1">MQWTMMLVLLLACLGVGEAVTECYDCTSSDAGCGDTFDKAAQAKYLKPCTTGLTDACYKGKVNGVVAIRSCMSTAGCAFSGNNDCFEESSDNVVCCCTGDGCNSATTRQVSYVALAAMMFVAKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRB8</accession>
    <name>A0A913ZRB8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054207.1">
        <property type="nucleotide sequence ID" value="XM_038198279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRB8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198279.1">
        <property type="protein sequence ID" value="XP_038054207.1"/>
        <property type="gene ID" value="LOC119726547"/>
    </dbReference>
    <dbReference type="GeneID" id="119726547"/>
    <dbReference type="OMA" id="CPEREYA"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037478998" description="Kazal-like domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="319"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="427"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="57942" checksum="A3DE8703E52DBD70" modified="2023-02-22" version="1">MTGTHGTIFPLLGIWLVVICCIYIPCVRADNDGPASQRRLSCKQSLRRCQRNSHGAITGEVCGSDGRTYPSHCSLLFAACRRHNSPQGRGRSPWPSLVHAGACQDDAYYNVRNNTGPSEAGGSNDGLLPFGEEEEEEEEEWEDQEGERERESEDKSSEKSSEEDESREEDEDNDGNPFNPATRPPTVSSAMTSKPPATTVSSATGFSAASVPNQPMPTQTDRTTGRTDPTQTGATTVPPTCAPSCPLDSNPVCGTDGETYNSRCLLEAHACQTGDQSLIVLYDGPCIPPGVVVPLPRRDPTTLASRREPRPTPADRPVRERLSYCPTEAECSMLYLPVCGSDGTTYSSWCHLRLVACRTPGETLTVSHMGECLESTNTGCGEPCPDVFEPVCGSDNMTYHSLCSLRRITCLRGEDLPTAHGGECILPALVCPLVCPGTNDPVCGTDGNSYPSLCVIRLVACRSADEREKELRMAYRGLCMNEPCQNSCPEREYAPLCGSNGRTYQNECFLWLEMCRHPDLVRFDKDCNLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTT6</accession>
    <name>A0A913ZTT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054486.1">
        <property type="nucleotide sequence ID" value="XM_038198558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198558.1">
        <property type="protein sequence ID" value="XP_038054486.1"/>
        <property type="gene ID" value="LOC119726732"/>
    </dbReference>
    <dbReference type="GeneID" id="119726732"/>
    <dbReference type="CTD" id="79657"/>
    <dbReference type="OMA" id="NFTPDRP"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="403"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="521" mass="59464" checksum="ECC0B371819A4298" modified="2023-02-22" version="1">MADKFLQMQQQLRHDNEDLQSYLRDLKNWEADIKQKDEALRQTKDTQDAVLPPIRNQGKRKPKQARKKKPKPATKPSQSEAGDQNRAGTRHSRIRAYDYRSWDKFDVDKACAEVDSDEEDEVPATQGENGEEMETDTDSEEERELERQRRIQEANMEKDKGNALFKQGKYEPAVVCYTAGMEADPTNAILPANRAMANLKLERFEDAERDCDKSISLDCTYIKAYARRAAARFGLGKLEDAKKDYQQVLNLEPSNKQASSEIKRIDRIVKDKEETERQKLDGVYNIIQAVQKPVHLRSNKPLKRMVIEEIGTGSGGEDDDATQTTHPHKPQHTTPSGRSEVSSPAEQRITGDCHEEDGTKSSETPTPVPSEVRVPDATQTELPPTVSQVPSKPTPPVDIPGIPSSSYQLQSDWKQLQKFSEQLFQYFKNIPPQSYKQLLQDSLDAALLMRILNLLKEQYVIHSEPVYETLAGLSQVKRFEMNVMFMSSKDKQVVQELFSYMERSGNVGEQELTQLRKKYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTZ5</accession>
    <name>A0A913ZTZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054546.1">
        <property type="nucleotide sequence ID" value="XM_038198618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198618.1">
        <property type="protein sequence ID" value="XP_038054546.1"/>
        <property type="gene ID" value="LOC119726772"/>
    </dbReference>
    <dbReference type="GeneID" id="119726772"/>
    <dbReference type="OMA" id="PFSENTW"/>
    <dbReference type="OrthoDB" id="8174896at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037539904" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="33"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="584"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1213" mass="132077" checksum="D3E3C1E85871C87E" modified="2023-02-22" version="1">MMPSVTRSMNLLLLNFLIFTACLQSGEGQFVITNTTSGPVMGVKTPLQPLTDQLVTRYTAIPYAEPPTGERRFAKPVPKAPWEDVLNATVYGPSCPQPGLNMADMDEDCLLLNVYVPHDAVASSGPLPVMIFIHGGGFTSGQSMTYDGTILALHGQVVVVNINYRLGLFGFLSTGDDSAPGNYGLWDQRLAIQWVKDNIANFGGNPDQITIFGESAGAWSVTYQMITPLNDRTLFQRVIAESGVVFPNLVIPATVARFQAFNVGSILGCNLPVVSTSRDLISCLRGISVETLLTQTYTVQSSAIIDGEFLPTNINTLLAHPRVGQYDLIMGFNDQDGSVFISQVSKNYTAEELRSDIQYFLLSCQCENPQEITDAVFAYYFGGQDLEDPDENVLRYLDVTGDQFFKVPSINFLTRHAESAANTSTYFYHFTYETGKEFFLPPEWSGLISGAPHALDTFYVFGFISAFYPNDLDAAILSNTTMDYWTQFARYGNPNGAGLPGLPEWPEFKTENGSYIILDPDFKTGQRFKPDKIAFWNNYIPTITEPASYKKTCSYEVPVRRGTLRKPDNMTLQISSKDGEVLGSVAGALRVADEAMGGQEIAEFLGIPYAKPPLGELRFRPPQETGPWGDEPLGIPANLPPACPQDVTRDPWMVRLGFNQTSEDCLTLNIYAPTQDPNDPALPVLVFIHGGDAEYGTSSVYDATLLASRVKAVVVVMNYRLGALGFLSTEDEIVPGNYGLHDILASLKWVNKYIGSFGGDPERVTVQGHGSGAILAHMLTLSETAKGLFNRAVLMSATAISPPVDNPVLPSASETAKTLASKLRCPTKTSEMMVSCLRNKPAAALVSVTISAPFGLAFPTVVDGDLITDKPLELLKAGRINDVDILVGLTQDEHAAVAFAFTGLDCPSTAEIQQYIDTVSRLSFTNPNKTAFALATEYIGKGGLDDDCQTRGSFRQFINDYLSYWSTLEAARLHADAGHSVYFYSIDLKPPAHHYKGPLPPQVGPTFADDLQFLFGDPYSPLGDELQLSYRLEDKRFTLELMAFLKMYTYNGDPGASLSGAKWPAFDSADLTYMSLTDCPQALSGNDNNWQHLLRFWANYLPSITAPAPTPPEPTPCPPEPTPCPPDRPCPLDPEPCTVSVGGLRLPLSEASTVIAALIGTTVGVGVLAIIFLGLCVANKKARANGAEKEKRLMEAGVGLTHIDTMDNGNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV03</accession>
    <name>A0A913ZV03_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Farnesoic acid O-methyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055382.1">
        <property type="nucleotide sequence ID" value="XM_038199454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZV03"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199454.1">
        <property type="protein sequence ID" value="XP_038055382.1"/>
        <property type="gene ID" value="LOC119727543"/>
    </dbReference>
    <dbReference type="GeneID" id="119727543"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="2">
        <location>
            <begin position="409"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="546" mass="59266" checksum="8AE7CC6D5DB4E47E" modified="2023-02-22" version="1">MRLYWYRVGSYFRMSPTSDIFLLCFITVVSLQAVAGCVCYVGQQSNQRKLTSSWVVLSRDPCGCSGFVPGGFNAKRSRPVWRHYPQAHTRTPGPIFTTGETDDSVKVKLRLGCPDAIAPNTEEAPTAAGIGTTPDIDENSNTEPIPNDATKTISQGVTESTLNIMTKSIPNITTELTPNIATKSIPNIATESTPNILTKSVPNIATESTPNIVTKSIPNIATESTPNILTKSVPNIATESTPNIVTKSIPNIATESTPNIVTKSVPNIATESTPNIGTKSIPNIATESTPNIGTKSVPNVATESTPNLATKFIPNSATEFDLKLATEIFPNLSATEPNIVTKSVPNVSATESTPNLATKSIPNIATEESDPRMATSASKATNEPPFDPEAPCESWVYHTTLNTYTYVFPFAAFDPDQEFFVKFGVRTGTTALLALTVTDKNPQGLEEELYEIVIDYEFSGTSGIRRCKDCESLVSATDAKDRLDEDAYKYYWLRYRGGLVQVGRRGETESFMTWQDDAPLSVRYLGLASNGWDSGWKMCEGMVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVR1</accession>
    <name>A0A913ZVR1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bardet-Biedl syndrome 7 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of BBSome complex.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055758.1">
        <property type="nucleotide sequence ID" value="XM_038199830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199830.1">
        <property type="protein sequence ID" value="XP_038055758.1"/>
        <property type="gene ID" value="LOC119727772"/>
    </dbReference>
    <dbReference type="GeneID" id="119727772"/>
    <dbReference type="CTD" id="55212"/>
    <dbReference type="OMA" id="KGEGCFK"/>
    <dbReference type="OrthoDB" id="414590at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016575">
        <property type="entry name" value="Bardet-Biedl_syndrome_7_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011091">
        <property type="entry name" value="BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="6">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="4">
        <location>
            <begin position="378"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="5">
        <location>
            <begin position="494"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="3">
        <location>
            <begin position="599"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="717" mass="80370" checksum="91D55C67E5BCC58B" modified="2023-02-22" version="1">MMELNLHRADYIQVGVTSPRSMRLLPEKKAKAAQRVAVADQTGVLQCFNMKKREPVSAFKTLPGPKINRLELGGALGMIPDKIFITSGSEVKGFTKKGKQFLGFDTNLTESIKTMWVSGSHLFLGGNYIFNHYVDCKDENYYLCSDRINDIVCLPLGRVKEVTPVLACQDRVLRVLDASNLLYEVEVAGPPQTLCLFADEGGEDGEEVLYGTSDGKIGLVQLGRSAPNHKWEIPNEKRSGGVLCLDNYDITADGIADLLVGRDDGLVEVYGYDESDEPVLRFSQTLSESISSIQGGTVATPGYDEVVACTYAGWIQGLSTEPPLKEAGPGDKVKVSQDTQNKISSLKAELEGLQRRVIQEREKYHYSAMNTKAISAVPYFNINDRFSLNRDDASYTLSIEVQVAIDNVLLQSDVPIDLLDVDKNSAVVSYSACDTENGNFLLATYRCQANTTRLELKVRSIEGQYGTLQAYITPRLQPKTCQVRQYKIKPLSLHQRTHVLDDTRPMNTLKLSGQFSLAEIHSWVCFCLPEIPERTPPGDSINFHFLSTFLDTQLDCLYRKGEGIFRSDNISTVSILKDVLTKEATKRKINLNISYELQDDSIPDTLRRLHPKLEYQLLLAKKVQLIDALKELQIHEGDLEFMSPEYRQILSDAGTLQAEYKKQPCHLERLYGMITDLFIDKFKFKGSNVKTKVPQLLEVLDNYELQNLIDFFNSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWI6</accession>
    <name>A0A913ZWI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055879.1">
        <property type="nucleotide sequence ID" value="XM_038199951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199951.1">
        <property type="protein sequence ID" value="XP_038055879.1"/>
        <property type="gene ID" value="LOC119727875"/>
    </dbReference>
    <dbReference type="GeneID" id="119727875"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22982" checksum="EEF557A645B7005B" modified="2023-02-22" version="1">MNLEVTDEELWGCVRQFDVKTLQEFLSKVDVPKSGSKDCLQKRLFYALKLGLPIVPTASNEELSRRESRERKLRFGEQFKLPHPLTLDGWEGTSANLPPITEEKVNHYFRTRNKELEISTDGSKSLGQGRSMAVSRGRVHTVEHHHISDIGSATFEDWLYHKQEFMSSHTWCGSLYLKIQVLYIRQIVIALQGEIHDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZG3</accession>
    <name>A0A913ZZG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056456.1">
        <property type="nucleotide sequence ID" value="XM_038200528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200528.1">
        <property type="protein sequence ID" value="XP_038056456.1"/>
        <property type="gene ID" value="LOC119728326"/>
    </dbReference>
    <dbReference type="GeneID" id="119728326"/>
    <dbReference type="OMA" id="HIVRPRC"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038008302" description="Peptidase metallopeptidase domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="117"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="291" mass="32832" checksum="A7031A04E8617F49" modified="2023-02-22" version="1">MYVLISACLLLVAAGRTQTNGMNVPLARGLGLEKLMEGMEYLKKYSYIHLDAGKDGNGLDMAMIKSGIGKYQVFHGLPKTEMIDEETLDKMDLPRCGCRDPEFTGEAERDEFRYWLEGGMWNKTELTVRISRIPNLMSKKSVRRVLKQACRVWSSRSPLTFTEVRSGGADINVKFMGTMDHGDRRAFWRPLGEVGHAFSPSDPALPGDIHLDASESYSFEEETDGINLFQLLVHELGHTLGLGHSPHPQSVMYPIARAYDPAFELSRNDMAGLHALYGRKSRARLRNRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2M5</accession>
    <name>A0A914A2M5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038057905.1">
        <property type="nucleotide sequence ID" value="XM_038201977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2M5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201977.1">
        <property type="protein sequence ID" value="XP_038057905.1"/>
        <property type="gene ID" value="LOC119729352"/>
    </dbReference>
    <dbReference type="GeneID" id="119729352"/>
    <dbReference type="OMA" id="IGGSHWP"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF51">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038168676" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="172" mass="19348" checksum="651F5FD9537B5EB5" modified="2023-02-22" version="1">MAGKSVVFLFVCALTLITEGQAASRQKRSLPQFALMMTCATGTNPLEYNGYGCYCGSGGSGTPVDATDRCCYAHDRCYSRLKSDGHCVKETGDVYTMLYRSKQKNCGQSNVQIICKRARQYNWLESLAVFWKTNCAAGACECDRQAALCFKRNRGTFSRSYVNYHKYTRCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2P9</accession>
    <name>A0A914A2P9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058112.1">
        <property type="nucleotide sequence ID" value="XM_038202184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202184.1">
        <property type="protein sequence ID" value="XP_038058112.1"/>
        <property type="gene ID" value="LOC119729572"/>
    </dbReference>
    <dbReference type="GeneID" id="119729572"/>
    <dbReference type="CTD" id="27151"/>
    <dbReference type="OMA" id="CGCARDC"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF139">
        <property type="entry name" value="C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="1670"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1734"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1757"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1797"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1826"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1866"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1884"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1936"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1961"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2029"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2042"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2102"/>
            <end position="2113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2113" mass="237214" checksum="DBD97FF90C3D0B96" modified="2023-02-22" version="1">MELNTRTLVGHLTVIFLSTFVLDVVVANEGYLIAHPELFRPGMVEYISVTIFEPSQPITVQARLVFKNETVASTERNIVGKGKLKLQVPGGVRGRVTLEVCGNCDIGATGYHFKNSTDVDISDKGTSVFIQTDKPVYKPSQRVLINFIMTGPDLRPKNEEMLAYIVDPQGSRMIQWRKLQPMCCGIINTSFPLSDQPMLGEWSVYAEVQGHTYNKTFEVQKYVLPRFEVIIEPPSYIADVTKCSQATVRARYIFGKPVRGKMSVNMNLHGLGYYNNYMGQNNYMFMDIDGSAKFNICISDMITSPLMDHFRGMVHIEASVTSNDGNVFVAMDESCLVQKQLVSLEFSKDSRKHYKPGLPYHGKVLLYYPDKSPANNITVEIVAEVKQDPFFSKNFISHNGVVDISIPSLPPVSGHVWINAKVVAIDGADAGDMYFYNYLSLGSWYSPSKCHLLLRSLQENVKVGDTAIIGVQSTCPCNFTMHYEVMSRGNIVTSGLHDAMLRSSSGRNDGSRRRRFSSHPVIDHFMAENEDGESDSQSCRTTFQFEVTHGMAPLSHLLVYYMRDNDEGVADTMVLPVEPSFENKIKVEMSKNETLPGSKMRMMISAKPGSCICVASVDQSVQLLRPGYQVTAEKIFAEMENYDITDDVSAETAWWGGAFGRRKRSTMWSRSRDANFAFMEAGLKVMTDKIHLNFHDSESVVLDDDWVQLSAVRSAGRDQLSDLERNARRKRAFFPETWMWQCFNLSSLSSEEHIQMRVPDTITTWMTDVIAMSPTYGLGVAETVPLTTFKNFFVEFTLPYSVIRGEQLRVPVTVYNYLDRCVQVDLIVHVQEGVRFLMHTERHQAYKLCLQAQRTETTYVTLIFSELGRKKIHASAEAMVSPDCCVGPVANEGIVGSDKITKNLLVEPEGIERGYAYSVFFCPNERTHISTPNRYSYQFVEKEEGMDFFTFMCKAKNDAHIALAATQDSYQLYEVVLGGWDNTRSWIARSRMGDALVTDLTADIVSWDEFRAFWISWKAGNIQIGHGEVPSNESVIMSWQDDNPMQVQYIGFTTGLGSLGEFRIWKKKGSSEIYREAFTLSLPLNHVQGSERASAVVIGDVMGPTLNNLHNLIRLPFGCGEQNMIHFAPIVYVMHYLQHTNQMDKETEIEANTFLVQGYQRQLTYRRHSGSYSAFGESDTSGSMWLTAFVLKSFAQSRRFIFIDPKELEMSKKWIIAHQQEDGSFPPVGKVLNKDIQGGIQGNSRLPLTAYVLVALMESGVETDEEKTAVSTAQKFLEDNVGSIVDPYTAALTAYALTLRNSPFAAIAVRVLTSKAIRKDSLTYWRLSGEALETLPFFSHVGDLEQTVTSAEVEMTAYALLTYTALGDIAYSLPIVKWLTQQRNAHGGFSSTQDTCVALQALAEYATLAYVGRVNLSISLAYTDLDLFVEDYYHLNNENSQILQVREIPVLSKTLFLSAYGEGCGLLQINMKYNIPDPTGKPAFKLNVNMIESVPYQTRRKRYVDGTTTENLMPSHDDYMVTLEVCTRWLHAGSSNMAVIEVSLITGFTADIESLDLLLRDKYTKVKRYEIDGRKVILYFDEIPSQCMTCVTFDAYQDFVVGKTHAVPVKVYDYYEPHFEASRFYNVSRDSPLARELCEDDHCNQVHETEDSNHSAEQQPMENYNPENCNSIFGDCQSTFDLIQCMCERTCDTGGPKVCASNNVTYDTYCHMEVAACQLNENLEAMPLSNCPVIEKPTEAPTSEGSGSVWGNHGNEDKDEGPDDESSDSSDSSVAWEEMGDHPGFSHWDMMQSPWKFEIESETEKKKGASEDEEGELPEIMWIKEGEEEEDAEDADQQGGDGELVDEPLPEPLPASSNSQGHHPSVGKDDEPDPVKEIPAVMETEQELEEDGVDLTNEELDKTDQAEVEDTWNGDAQTDEREDADVTMETRMRTGEEDDNPENPMPDDEEEGDANEEDEGTMLREWLHGDQEAKTDDETTDDEAAVETGRDFEMDAGKTTQADEEVEEEQPSAAGVPSTSEGAPRHHVHPEGDAKAPDDNLSAHNPQGASEESPTQLTEETAPVHLSSPRVIGLDTMVNDEARLAVDDEEENVQQEENHKTTKERRKRGLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3T8</accession>
    <name>A0A914A3T8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058335.1">
        <property type="nucleotide sequence ID" value="XM_038202407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3T8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202407.1">
        <property type="protein sequence ID" value="XP_038058335.1"/>
        <property type="gene ID" value="LOC119729712"/>
    </dbReference>
    <dbReference type="GeneID" id="119729712"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000122">
        <property type="entry name" value="Centrin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000301">
        <property type="entry name" value="EF-hand calcium-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="19701" checksum="8094EE7B2A9E7CEF" modified="2023-02-22" version="1">MSLSLRSEFGMDKGRRKKRRELTEEQKQEIKEAFDLFDTDKDRAIDYHELKVAMRALGFDVKKADVLKVLRDYDKDNSGKIFFDDFNEVMTDWMLDRDPHEEILKAFRLFDDDDSGKISLRNLRRVARELGENMTEEELRAMIDEFDKDGDGEINEEEFVAIMTGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4A5</accession>
    <name>A0A914A4A5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058682.1">
        <property type="nucleotide sequence ID" value="XM_038202754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4A5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202754.1">
        <property type="protein sequence ID" value="XP_038058682.1"/>
        <property type="gene ID" value="LOC119729961"/>
    </dbReference>
    <dbReference type="GeneID" id="119729961"/>
    <dbReference type="OMA" id="VEYMIAN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56991" checksum="2412970E48E1C4CD" modified="2023-02-22" version="1">MSVLQNMMWLLDVRTVLLCVVVLLVLRWFLGRPKNLPPGPWGFPLIGSVPAIVREIRRGVEPHDLFIRYAAKYGPVFRLQIFNKTAVVLNDYTSVKEAFQHPQLQDRPEMLIQKILSDGVATISGQPWVELRRFCLTALRSFGVGKTSFEEKIGTEAEELVKEMSAFNGKSFNPKHLLGNAVSNVICSVVFGKRYEYTDKEFERLLFLLARNFELLGSGGAINYFPELRHVPFLPTSEIVSNFKEIREFLLKVIDKHRAAFDADDLRDFIDVYLVEVKNNQAKDDIGEEHGYLTDDNLVGTIENIFAAGSETTATTLQWALLYMAVYPEIQQRVQTEIDAVVGRNRLPRMADKPELNFTRAVIWEVQRLSLIVPFGVPHAAASDTQFHGFMIPKGAFLVPNLWAVARDPKVWSDPDQFQPERFLNDKGEAVQADELIPFSVGRRSCIGEHLAKVELLIFFSFFLHQFTFKKPDNSSPLSLKGKNGITYSPEEFDICAMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4G3</accession>
    <name>A0A914A4G3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PFL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038058448.1">
        <property type="nucleotide sequence ID" value="XM_038202520.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058449.1">
        <property type="nucleotide sequence ID" value="XM_038202521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4G3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202520.1">
        <property type="protein sequence ID" value="XP_038058448.1"/>
        <property type="gene ID" value="LOC119729778"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202521.1">
        <property type="protein sequence ID" value="XP_038058449.1"/>
        <property type="gene ID" value="LOC119729778"/>
    </dbReference>
    <dbReference type="GeneID" id="119729778"/>
    <dbReference type="OMA" id="YVVAACW"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051215">
        <property type="entry name" value="GRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43641:SF2">
        <property type="entry name" value="DEHYDRATASE YBIW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43641">
        <property type="entry name" value="FORMATE ACETYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="11">
        <location>
            <begin position="381"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="8">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="135270" checksum="9F7FE810F40569D6" modified="2023-02-22" version="1">MEQRAVKRQKKRHPETRRSLADSAHAKESTYLLAQPGIFFTRPKYGCMVVVNLNDKTETGKTGVFNAIQAVQQKCDLLQGRNGYVVSFDPALWKTWSPNDDIEDRPQGNYMLSSSRKFVNTGGDVSFFLKSDTEDVVPKLFQEVENNLHALASLDVTQTRVYNDRAINGKFRDGVDNPVDKTTVERFILTPQTTTPGSGGGSYFYTQKFRMNFSIFDKMTIRQQENVIGRKVTDEIVIGADSRSHIRRARLAEASIHLKILRGSMPYGRDDTGQEGIYFNAFADHVQLFIDLMQSLVGDDPDFTQDKLISMAQGIEGSFWYTPSLHQLGFTDEPNVGQAPTLDFLPLWDVRSTNDYMFYNWREYLHRMSFGLYAPGDPPTHRVIKLLSVIFSEWSDQWYEKPNTARIPHLSNYLTAAEKPYLEESAAIRKGMAIKKTLGTLIPKRAYGTNNDLFRIHPNELIVGVMPRFSLGVGKYVMPYSREEEEFPWFMKGLNEGGAMGHIVPDHGIVLAVGLGVLKKQHQMLYARAPREQKDFYQSVILALEGVQEYIDSFANLAEQLAQKEEYTAEEKQNLRRINARLLKLKTGAPSNMLEAVQLLFLMHCSMHLIGNPVAIGRLDVLLSPFYDETTTPEAEAQEILDCLWIKLSERVVINRHFTPDLHDRGSTAVMYAASGNFGQGSAVNQWVQQITVGGYQANDDVTPTTACNKLTLLCLKSSRRIPTNAPCLSLRLHKNMPENILQEATRALLSGGAHPILMHDDRLVPSLMNSGSPDVPVSLAAARNYACDGCYEPMIAGETEFAFGTIILLNILEMTLNEGTLYADSGSVYLRGLKVSYPSPHSSQIKTFDQLKEIFLKHLRLQTAQFYITILSNYGNLWDICPSPLLSSLIHGCKESGRDLSNGGSNYHALAMMYVSASNTIDSLYAIKKLVFDPDESLTTLPQLLEALKLDWGFEMREPFFDERAGEVREDANAATYKTLRKKALTLPRFGRGNPEVDEIANWLMENVVSIAKDTIHHPPSVLDGIISGIKEKYSLPGRPFGFVVEPGIGTFEGYVPQALGTGASADGRRSRQPFASDLSPSPAPQDKTAQPASVNIYQAMRSFDYDSINIGLSNGSPVDMNVGEDFPEAKLHEFIRHYANRTKPIGSNLITVTCANLETYQKAVDEPERYDLVRVRTGGWSEHYVAMFPAHQEQHQRRVVFTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4H4</accession>
    <name>A0A914A4H4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RPA-interacting protein A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058281.1">
        <property type="nucleotide sequence ID" value="XM_038202353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4H4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202353.1">
        <property type="protein sequence ID" value="XP_038058281.1"/>
        <property type="gene ID" value="LOC119729678"/>
    </dbReference>
    <dbReference type="GeneID" id="119729678"/>
    <dbReference type="OMA" id="ACDSWTV"/>
    <dbReference type="OrthoDB" id="435311at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028156">
        <property type="entry name" value="RIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028159">
        <property type="entry name" value="RPA_interact_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028155">
        <property type="entry name" value="RPA_interact_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028158">
        <property type="entry name" value="RPA_interact_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742:SF1">
        <property type="entry name" value="RPA-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742">
        <property type="entry name" value="RPA-INTERACTING PROTEIN RPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14768">
        <property type="entry name" value="RPA_interact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14767">
        <property type="entry name" value="RPA_interact_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14766">
        <property type="entry name" value="RPA_interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RPA-interacting protein N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="RPA-interacting protein central" evidence="9">
        <location>
            <begin position="67"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RPA-interacting protein C-terminal" evidence="10">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27064" checksum="4F857603422D9900" modified="2023-02-22" version="1">MATPKGKSPTFSRMEKHRNLYKNTSPQWRDSYRRRCFDRLRSSRENLLQKFRGNEAAADGGSPGRGSVVSELMAEEWKLMQWEQRQARVEMKLTHGQMDDDLLEDLNNDVVMSLVEEIQRELMAEENAIIAEYEASLQLAEASLSATVEQLDIDELSCPICKRNPLMLSKGVIFCACGIRINTEQDCITLANVRQQLENGVGQHSALCHGQPVFTVTDAFNAQNLVLSCQTCDFLYIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5T1</accession>
    <name>A0A914A5T1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS22-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059163.1">
        <property type="nucleotide sequence ID" value="XM_038203235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5T1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203235.1">
        <property type="protein sequence ID" value="XP_038059163.1"/>
        <property type="gene ID" value="LOC119730371"/>
    </dbReference>
    <dbReference type="GeneID" id="119730371"/>
    <dbReference type="OMA" id="VSACEHK"/>
    <dbReference type="OrthoDB" id="8193282at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042320">
        <property type="entry name" value="MMS22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029424">
        <property type="entry name" value="MMS22L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547:SF1">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14911">
        <property type="entry name" value="MMS22L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS22-like C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="115" mass="12489" checksum="3C7830652BF09FF2" modified="2023-02-22" version="1">MTLLLTAMMDACKKDTPLNLQTQLLSVLRGFLSKHLRVHQAAALRSLETVAVQHPALITALISDCSRLVSACEHKRGVGADSTLRQAYCNVLSHLGEAGEAVITRIKNGEKLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A689</accession>
    <name>A0A914A689_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tuberin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Lysosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058921.1">
        <property type="nucleotide sequence ID" value="XM_038202993.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202993.1">
        <property type="protein sequence ID" value="XP_038058921.1"/>
        <property type="gene ID" value="LOC119730199"/>
    </dbReference>
    <dbReference type="GeneID" id="119730199"/>
    <dbReference type="OMA" id="IRWFTSC"/>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000004">
        <property type="entry name" value="Tuberin isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="13">
        <location>
            <begin position="1730"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="936"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1065"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1586"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1971"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="962"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1311"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1665"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1993" mass="222863" checksum="620661FA1EF24B94" modified="2023-02-22" version="1">MARPASKESFKQRITSIFRRKESANIPNVATESRFEEFLITPALLKEIHRESPFSQRVKAVRDLCELVTTKRLEDNGIEALWAATADFLEPQVPMEHRHLMLTFMKCIIVGQNERLELMRAVFFEVIKKHSIFEDLPQRLDVLKSLSANGKNLLHFEEDMGPFLLAWMPDVISYGMTAEFLGLLVNVFKFNSCYLDDHIVSGLVRHTCTVCSRTGREYDIEQSLKVLEAVVCYSCLPTDALYNFVTALCRTVGVQEFAQASWKLMRNLFGTHLGHSAIYTMCSIMENGQNQGDVILLRGAVFYVGMARWGSMRVQSLKHNFTSVLPSFLKALRCKHPTVAYEVTLSLQRLVKKYGKDMQPVTWDIVLDIIEDLFRNIQIYSTHELLPDDLHDLLTTTELLHESKSFSGSASRLFGIVEEFANIRPESSVLTLVSFRAQSIHPTKVDWIQNLQGLMDSYFRTEDRTAIREAALRVLSSVLSSTSHLYEDDLIEMVVLPQLGHISEDPDPVVRQAAVHLLMDVAQVCQTHRCVDILDIIQKVVMRPMHTEASLGITLEPTDTSKNLVPHQRVAETDEDLVDIKAAVLSLMELFRSKLYRLPSNHCVLAFELLVKHMQAQYQHTFNSVTARTIRLMVFEYLLMLRSDSMYHIGLPDKDGNIRYSSYVLCDYKLEMDITGKTSPPSVCASPPIVERFCKTTFIPFADAFKVITTCLKYETDWHVLNKVSQSLAKALQNRTLVLASNANLDLLCLTLCTMVDDKSHIRRLHHTPQTFTRADFYVGVYRVLTALVPYHTQLENRRQVDLIKCLEAGLKLKCAQQCVDGLTLCVMEMQNTMVKILPSIILEMSKMSATPNMAIPVLEFLSSLIWFPHLYTSFVENQYMSIFAVALHYTNPFKFSLYVVSLAHHVIAMWFIKCRLAFRREFVNCITRGLRASSPKMSLDSPGRVKLRRSSSLTEKTSQLSKKDGGKSQEKTQESERASTEILSELHSLLTEGCLDMMARYAHSNCTTVPKRSPVAEFLLAGGQSQSWLLGNKIITITTSGGSSRMQKNGICEKCQSLIKLETGEDPKQCSTESSTIWKSGESSKSVDEPSGEQLALSKGFLRRQRSKSGEKSSSHGTTSPSSSPLPTDKSKSFEYNAPPTPEKSVSETRGSRANSPPPPKSGRTSGDSHKSKSGAASPGSTGRAGSPVVGELKPQAETSKEFMERVQASLHERAESSAAKLSSLNVYQCNCWCQGWAEVYVRRPTGNTSWIMRIENGGALLPTTQDFPLADISSLLLRNRELDLEIDAIEFEEDDDDKDDTEEMILEGDGKMGSQEKDVEHSNQSVAKQQANNLSPTTPDLHVSGESAGINDVGDETQFFPPVMVPLPFGSGPAIVVDPSFIYHGSSFSDDGDEDFKFSKPKLGQSPQVHHGISYFPGYTAAHTDTEDQSVDMATVIEDATTDLENITELVEDPTTDRRIFPRSSSCPNIMETLTSTGSAEAETEDPDELSTSPRTVVKSFQQKQAPISSSYKEMSILEQRLLLQDSAFGSACKDSDAHPTVNVQETTNQEGESKLQDAVDLMNKDLLQTEVVSTAAATSSAKFLVPPDDVSPYTPDQTQRRGGQKKPRPVSLPPQTNGEELQIHVATSDTKKQTYVGVDALKRQQRTELHSVGRPRGHTVASMVSSASNEEYTGRRRRTSENRPRVMNRTGLSPSFIFLQIYYSPMFSDDTERPMALPLSQVTQRAVKVLDRIPPYDTHKIGVLYVGSGQTKDQTAILSNVYGSTRYVEFLRGLGRLISLKDVSPNEVYTGGLDHQGSDGKFAYWWHDDIMQVIFHVATLMPNKESDPTCNCKKLHIGNDFVSIVYNESKEPYQLGTIKGQFNFAEIVIEPLDSESNLVTVQAKQDLEAMIGSRGPRMITNKNLPLLVRQMALHANLASQIYQSQMRGSLAEAYTSNWLERLRQIKRLRGKISQGAPSNTLAAMAATSSLRHHERRKGSSVTLDDFTDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6D5</accession>
    <name>A0A914A6D5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059363.1">
        <property type="nucleotide sequence ID" value="XM_038203435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6D5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203435.1">
        <property type="protein sequence ID" value="XP_038059363.1"/>
        <property type="gene ID" value="LOC119730487"/>
    </dbReference>
    <dbReference type="GeneID" id="119730487"/>
    <dbReference type="OMA" id="SFSEWIC"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="383" mass="42976" checksum="FF401F884150E805" modified="2023-02-22" version="1">MGSCTSSGECGTLQTFNISAEAASQWLYTPADRVIMPIVIPIICLLGILTNSTFLFVLFRVPQLRSDTNVYLAHLAVADVLYLCMTTAIYVWLFASSPVAFDFPFENSASCVSFILVLNTGYFTAIAAVTAVSYERYLALCHPIKHRQIRTRVRTYKMTGLCWLLGLLFASSTVPHSARLILQKFQWPDDDEYQDFPSLVTRCDAVSSWVRYAVPPFQNFPWLITMAANVYMYIQIVRQLNNRRSKNSTMERAQKALLLRNQVAKMLVVNGVIFFMCQVPYRILSFSEWICLIGHIPDPLLITLGSGARWISTLPQLINAFINPLVYGVMSEQYRVALAQVFGCKGRARQNNSAHPPFVISAPGNKNSSTDNATTSDTNETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6Z5</accession>
    <name>A0A914A6Z5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059540.1">
        <property type="nucleotide sequence ID" value="XM_038203612.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203612.1">
        <property type="protein sequence ID" value="XP_038059540.1"/>
        <property type="gene ID" value="LOC119730625"/>
    </dbReference>
    <dbReference type="GeneID" id="119730625"/>
    <dbReference type="OMA" id="CEKETTQ"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21186">
        <property type="entry name" value="CH_DMD-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000075">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035436">
        <property type="entry name" value="Dystrophin/utrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002341">
        <property type="entry name" value="Dystrophin/utrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="179"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1804"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1845"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="964"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1845"/>
            <end position="1941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2243" mass="259226" checksum="5D3E4E68C1680C41" modified="2023-02-22" version="1">MRNDLALPTGQEYCGEEFLDSTGRLNEGSVADVAGIACLVYCILDCLRSGCFLDQREDIQKRTFTKWLNSQLSRDKKSDVVNDLFLDLRDGNHLLSLLEVLCGQKLKREKGHMRLHHLNNVNRALQILSQQQVRLVNISNNDIVDGNPKLTLGLVWSIISHWQAQELLNTEMSDSSRETSTEKTVLNWCRETTQGYRNVDIRNFTTSWRDGLAFNALLHKYRPNLFDYDGLLKLDPEARLEHAFRIAHEEFNVHRYLEPEDINVELPDKKSIMIYVIDMYKILSQQTEVISSRSGHARSGVGKTSSSEHTPVTPSSETSFSDMSEVDLESYQGNMENVLAWLLEAEDHLGHQGAISDNVDKVKDQFHTHEEFMMELTSHQNSVGNALQEGNHLILENKVTEDEENEIREQMSLLNSRWENLRISAMERQTKLHEVLMELQQKQLDDLAAWLDRTEEVISRQEGLGSNLDQVSQQVEEHRMLQESLEEQQMQVNSLTHMVVVVDESSPENATALLEEQLTSLGERWARVCQWTEQRWAILQEVSAHWQRFVEEQRQFSDWLSDKESTLARMRLADVQDVKGAIERVKILKILEQELEIQRNQFDKLNRSAENIVEHLDENNRAVEDIQLVLDEFSQRWDSVVQQMEMHSKWIAESGINLDAIPITDSINTTTTTKTYRGDSGNTVTETQVTKTITQTVHVAPSPSSAASEPHKRPHEDSQLKRQFDGELGSLVSWMEDTEQKLMTSNEPSPEDPNLDEQRKFYSTLERDLNERKARVKNVSELGNKLITQTRLEGTSTEPIRHSLENLQERWQDVRVMVDGRKRNLDQSSQRKQFTDELKRLQEVVQSVQGWLDEQATVADSVQGIQAQLDQCRAKQKEMTINSHRIERLTATARDLTGDATISRTAQRDIRAFKQSWEAASTALKDREKLLGKALDCAPPQRYIEAMRALTQWLQSVEAVLRSEEFCVTEVDELEDQLQKYKELQTTIQQQRPNYDFVNKTGKDLVSGAPSPAQSETLQRDLSKMNQGWSEVTFLVEERQGQLERALSELKLWQDEVNGLKSWMAEVDTFLSAEEIALGDMEVLQAQLEQGQALTDDIQTLQQNMDNITETGQKLAKEGDPPFAARITAELKQLQTKWTRVTKLAQEQRQSLETAHGICKKLKGEMQELNDWLDVTETDYISKDASIQDPADIQNKLKKVKKVQEDTTAKEPIVTSATKGHTALTAKSPQDSTLSSEYTTLLARWTTHQDKLASAHKTLTEAADNWRQLKVLLEEETMWMEGFEKKLKNPSLSLDAEEISEEIDTLELAVQKHAVDNSAKINKLSQSLISNDIMVSAVERETKMYNQKAKEIVTQAKECQQRLENNVQLLQQLEKDMLVLQSWITVVDRTLNNRLASRVSALDVPSEFEQMKSEFEAHETVLSNINNRATALMEQTSSTANQRLHQQVEILRKNMDELQHKFRKFQKPSDFEPKMAHVKGILDNVQEGIGVLVVKNREPEVIKTQQDACMGFYKTLSEIKHEVEYVIKTGRSVVERHQLDNPADLTERLNTLKLLYNQLGKRVTEGRDELEKALSLSRKVKKELVSQGEWCQTKETELGRRCEEDKEGTPQSLNQEIEWCKKLEHDIKKHQTSMGECKKLADKLIGLAEEGSLGAIKDDCEDIEGRLAKLSGQIRDRHIQLKKYLDQIAEFRRSLSEVKPWLSEAEKILDASDKLPREEKVSEEEVARCMKLQEESEDLATRVEEIRDQALELLRLGGDCRRSTEPDLISLNQRWEDVCQRAKEKQLEQKTIVAEMDEAARQLEEAERRRAEEEEKRKEQEERLKEERLKEEVRLKEEERLKEERLKEERLREEERLQEEQLKEAEQLREEQLMEERLREEERLKEEQLKEEERLKEERLKEERLREEQRLKEEQELKEEQERLEAEREQERLKREEEERQAAAAVEAMPKEEDEHLVAMETEVVVQSSPDHMDVPDDTETSAQISEDIIDEAVQCESIDELETQPDLSSLQWVTPGELLAQEVQENSDKTNSLIEEQCEQQIVETVEAAVNFDEMFAGKDDEEVKDEEAERHVAEFHVVLEQTYQAIDLCDHRLVDGMDLRPEDFDQDAEQSVQDTDEAIGALQPDVENLISQGEALISEVQERDPRQSRHLEARLGTLRNRWNTLQGDAEQRNDALREVVPRWTAYEKEVSEMGAWLEELGRRADEGKEDEDTIKVRQTFLFTTVGQFYRTNFCKLSFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A881</accession>
    <name>A0A914A881_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038060034.1">
        <property type="nucleotide sequence ID" value="XM_038204106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060035.1">
        <property type="nucleotide sequence ID" value="XM_038204107.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204106.1">
        <property type="protein sequence ID" value="XP_038060034.1"/>
        <property type="gene ID" value="LOC119731093"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204107.1">
        <property type="protein sequence ID" value="XP_038060035.1"/>
        <property type="gene ID" value="LOC119731093"/>
    </dbReference>
    <dbReference type="GeneID" id="119731093"/>
    <dbReference type="CTD" id="11128"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="249"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1391" mass="155458" checksum="578403E8865166E2" modified="2023-02-22" version="1">MVKEQFRETDVAKKISKVCFGLMSPEQIRQQAHIHVVSKNLYQPDNAARTPIPYGVLDHRMGTSEKDNPCLTCKKPLAECLGHYGYVDLELPVFHIGYFRSIISILQCICKDCAHILLPTADRQSFLDALRRPTLTYLQRKGLRKKISDKCRKQQNCPACMAFNGQVKKCGTLKIVHEKFKSTRRGREGAMVQFLADVDIATQHNKDLEPFLSKAQECLNPLTVHNLFKRIPQEDIPLLVMDSDSSRPQDLILTRLLVPPLCIRPSVISDLKAGTNEDDLTVKLTEIIFLNDVIRKHQQAGAKMSMIMEDWDFLQLQCALYINSETSGIPLNMQPKKATRGFCQRLKGKQGRFRGNLSGKRVDFSSRTVISPDPNLRIDEVAVPVHVAKTLTYPEKVTKANIGLMRKLVVNGCDLHPGANFIQQRHTNNKRFLKYGNRQKTAQELKYGDIVERHLMDGDIVLFNRQPSLHKLSIMAHFARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALTLMGVKSNLVTPRNGEPLIAAIQDFITGSYLLTQKDVFFDRAKACQLIASMLSQADENLKVKLPAPAILKPRCLWTGKQIFGIIIKPNDTCGIIMNLRAKAKNYCGKGLDLCFNDSYVVVHNSQLMCGAMDKSVLGSGSKNNIFYILLRDYGESYAADAMSRLARLCPFFLSNRGFSIGIGDVTPGEGLVSAKMDLLTAGYTKCDEYINDLETGKLQTQPGCSEEETLEAMILKELSVIRDHAGKACLKELHKSNSPLTMAVCGSKGSFINISQMIACVGQQAISGHRIPNGFEDRALPHFKRHSKVPAAKGFVKNSFYTGLTPTEFFFHTMGGREGLVDTAVKTAETGYMQRRLVKSLEDLCSHYDGTVRNSMSDIIQFEYGADGLDPAMMEAKDKPADFDRVLHHITSKFSCREEYTMSSQALHSEAYGVIDGSDFKMCSPDFRQELKCYIDSVCEKIRTCRAQCGLSEVQQERNVLYQLERITPTQLQEFLSMCRSKHMRARIEPGTAVGAVGAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKNISTPIITAQLDIDDDADFGRLVKGRIEKTKLGEVSEFIEEVFLPDNCFILIKLDMDRINLLKLEVNAESVRISICASKLRVKHQNVEVISASMVTVMPQETSKSSMYYTLQFLKENLTDVVIQGISSVSRAVIHIDDKGSKALYKLLVEGDNLQAVVATRGVKGTTTTSNNTSEMEKTLGIEAARRTIIEQIEYTMVSHGMSIDHRHVMLLADLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYHGQKDAICGVSECIIMGIPMNIGTGIFKLLHKAEKISSPVQRQLIFDNPNFHLPEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9B6</accession>
    <name>A0A914A9B6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060026.1">
        <property type="nucleotide sequence ID" value="XM_038204098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9B6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204098.1">
        <property type="protein sequence ID" value="XP_038060026.1"/>
        <property type="gene ID" value="LOC119731082"/>
    </dbReference>
    <dbReference type="GeneID" id="119731082"/>
    <dbReference type="OMA" id="MFTDKAH"/>
    <dbReference type="OrthoDB" id="10043918at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="234" mass="26944" checksum="ED498DD0A223E7FE" modified="2023-02-22" version="1">MGLVRIPYYQDYWSSEPGYYNRLISTTMTRSRFDFLTQHFACSDPATNPERYPHEDPTMFTDKAHKYNFMAKHPLYPLQPVWDTVLSKCRANFNLGRNLAIDEAMVKYSGFKAHVRKFFMPLKPIRTGFKLYALADSATGYLANFIVQPFKSGAPAKMTDIAMAVASPVFGVYHHIFGDKLYSSVELCQRLLADRTYYTGAVKSTSKNLPRDFRTNPDKNPQQHQKIKNLNKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAD8</accession>
    <name>A0A914AAD8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060354.1">
        <property type="nucleotide sequence ID" value="XM_038204426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAD8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204426.1">
        <property type="protein sequence ID" value="XP_038060354.1"/>
        <property type="gene ID" value="LOC119731289"/>
    </dbReference>
    <dbReference type="GeneID" id="119731289"/>
    <dbReference type="CTD" id="347732"/>
    <dbReference type="OMA" id="YETMAVY"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47131:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="50"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="395" mass="46194" checksum="2691EC8955F009FC" modified="2023-02-22" version="1">MSEMQKKISEESVVSDSGSDLIIDDEGPELRWVRPDMSFHRFVVKITESTIFNAFIMFTIVLNAIAMALETDFTLKARYRTAFLVLDELFLGIYTLEFMMKIYAEPIRYFYSSYNLFDLLVLLMSYVQVLLIHVAGGQTNLGALRTLRALRTLRTLRTVSFVRGLQVLVTALLDTIRNSVINVVLLLLLMMFLFGIMGYYFFGYNEGSDKEHWGNLGSAMLTLFSYVTVDGWTDLQAELDKRNMTGSRFYTIAFIFLGHFIFTNVFIGMIIMNIHDATEAYRREQELEKEEAVQKKKEYMIQRQHNEVRQMIDKQNRGHYKNFSDMVREFQNTLSHDDYVISVDLATNLTWLETYIASMEHHDNTVYRLQQLQFEMCHLLASVLERKLKERYGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAQ2</accession>
    <name>A0A914AAQ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060945.1">
        <property type="nucleotide sequence ID" value="XM_038205017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205017.1">
        <property type="protein sequence ID" value="XP_038060945.1"/>
        <property type="gene ID" value="LOC119731763"/>
    </dbReference>
    <dbReference type="GeneID" id="119731763"/>
    <dbReference type="CTD" id="832"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="273" mass="30681" checksum="60310505658289B1" modified="2023-02-22" version="1">MGDLDRQLDCALDLMRRLPPQEIEKNLSDLIDLVPDLCEDLLSSVDQPLKIARDSSAGKDYLLCDYNRDGDSYRSPWSNKYDPSLEDGAVPSDKLRKLEIEANIAFDTYRDLYFEGGVSSVYLWDLDHGFAGVVLIKKAGDGSKTIQGCWDSIHVVEVQDKSSGRNAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQAEKDSAVSEATPHIFNIGKMIEEMENKMRTTLNEIYFGKTRDIINDLRSVGSLNAMDQQKQIANELIKNFQSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC37</accession>
    <name>A0A914AC37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038060904.1">
        <property type="nucleotide sequence ID" value="XM_038204976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204976.1">
        <property type="protein sequence ID" value="XP_038060904.1"/>
        <property type="gene ID" value="LOC119731736"/>
    </dbReference>
    <dbReference type="GeneID" id="119731736"/>
    <dbReference type="OMA" id="ANSPWFA"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903251" description="Multiple inositol polyphosphate phosphatase 1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="515" mass="57877" checksum="797E5A28291B26A9" modified="2023-02-22" version="1">MEAFEFIVFNVFSLIFLTACEPIIGNVPLYATKTGYDISIETTGRVNNVEKNWLELARSTGASVPEGLENCTPHGVYAVYRHGTRYPSDGDIEDVHNIIDRLRSTDVNPEFQFLRDAVKIPLSNASQLAETGYREMRELAARMANRFPVLFPDSDVDLSRYSFQSTGKTRTIDSARGYIQGVVGEQQICKTNYSERSFTVNCTENDGTQTPTSTTVPHNPIDDDLLLRFYDVFEDCTEAINGGRTDREQDEFRDGPDVGEVWQRVAERLAGPGRGTWNISREEVILLTEICGYDLTLNNDNETWCKLFETQDLYAPEYHSDLKNYWNKAYGFNINYRISCTLANDALKYLQDRVDNPTQSPLGNFKFAHTDTIVPLLAFLDLFDDPLPLLASNFLENINRTFRAAHMSPFAANVAFALYGCTTDSAVTYRVQMLLNESPVQLEFCEGQFCTLDEFQTGIEARIGTCDFTEECAEALQDRTTPNPGGSGADINYSVCLQFLLAYVMLVALSFTGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD93</accession>
    <name>A0A914AD93_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061451.1">
        <property type="nucleotide sequence ID" value="XM_038205523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205523.1">
        <property type="protein sequence ID" value="XP_038061451.1"/>
        <property type="gene ID" value="LOC119732127"/>
    </dbReference>
    <dbReference type="GeneID" id="119732127"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="128" mass="13410" checksum="069CE7958F9A4EE3" modified="2023-02-22" version="1">MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGSQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADM2</accession>
    <name>A0A914ADM2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061586.1">
        <property type="nucleotide sequence ID" value="XM_038205658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205658.1">
        <property type="protein sequence ID" value="XP_038061586.1"/>
        <property type="gene ID" value="LOC119732224"/>
    </dbReference>
    <dbReference type="GeneID" id="119732224"/>
    <dbReference type="OMA" id="SIHASEY"/>
    <dbReference type="OrthoDB" id="639466at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56633" checksum="CB0074CC8BF28F22" modified="2023-02-22" version="1">MEALRYIHDNLGISYSLILCLVILLALRVIFKARYLPPGPWGFPWLGMVPYFLLVGRFGGVQRHEALARLAARYGKVFSFTAFGKVIIVLSDPQAVRELFSRQELNDRPEIHIENIPTGTGVALANGERWKQQRVFTIRILEKYGVGKPAFEENIASEARALLRELEKLNGEVFNPKHHLMLCVSNIITDILFSTKHEYDDADYKNYLDMVAEITHLMGTSGATHSLPLINLIPLPSRIRLSQILGSEFDDMHKIIKKHRDRLDRGNLRNFLDEYLNEVVSRREQGSPSEVNDANLPETLVQLYSAGTENTATTMRWALLFMIGKLDVQAQVQAELDRVVGRERLPTLSDEPLLPYTRATLLEIQRLGSVTPLGVAHFSASDVPYRSWTIPAQSTVIPNTWAIHNDPDIWKNPGVFKPGRFLDEKNQIVNDDLIMSFSAGNRICPGRHLAKMEIFILFTHLMHRFQFRKVGSSPLSFRGHGSFARVPDEFELQISLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEF6</accession>
    <name>A0A914AEF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EMI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061744.1">
        <property type="nucleotide sequence ID" value="XM_038205816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205816.1">
        <property type="protein sequence ID" value="XP_038061744.1"/>
        <property type="gene ID" value="LOC119732359"/>
    </dbReference>
    <dbReference type="GeneID" id="119732359"/>
    <dbReference type="OMA" id="ESGCMYR"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087628" description="EMI domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="4">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="19541" checksum="E8E373DE8E037AAA" modified="2023-02-22" version="1">MARSAAFITVLVMGLLAELKLVGTQYIPPQGGVNYNDQQQQQGYYQQQGNQQQQYAGYGGGPAPGSMDPIPVRTSGIPMASSGNELGAGMPHVCPYQEPSMIGHRRPCVKAYTRMVKVWRPNCGYSGQWCVGYERRTAYYTSYRLVYENSYVTRYKCCHGWSRFNGESGCMYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGC8</accession>
    <name>A0A914AGC8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063030.1">
        <property type="nucleotide sequence ID" value="XM_038207102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207102.1">
        <property type="protein sequence ID" value="XP_038063030.1"/>
        <property type="gene ID" value="LOC119733719"/>
    </dbReference>
    <dbReference type="GeneID" id="119733719"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="117" mass="11682" checksum="9769D2044548802D" modified="2023-02-22" version="1">MITAPPEPAYPASPMPAAATAPPVPAYSPVPAAATAPPVPAYTASPVPTAATAPPATLGGKPLALLKSQQAHQPESSDDSDDSTAEDAADTDAPIPVSSKAVTTVKNSFWKLPWKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHD5</accession>
    <name>A0A914AHD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063098.1">
        <property type="nucleotide sequence ID" value="XM_038207170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207170.1">
        <property type="protein sequence ID" value="XP_038063098.1"/>
        <property type="gene ID" value="LOC119733801"/>
    </dbReference>
    <dbReference type="GeneID" id="119733801"/>
    <dbReference type="OMA" id="DNAWSHK"/>
    <dbReference type="OrthoDB" id="6418377at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF33">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036964099" description="Reelin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="20814" checksum="A077E6EB92B33B64" modified="2023-02-22" version="1">MMKYEALVFTVSALVVLGVADAFPDGASPRACVDMVPGHSSTTEPGRVISPQESISPYSVVARGDGYTPGGTVSVSILAEPSNITFQGFLLQARTLTSLDPVGTFLAGTDGASRLLTCNVTGDSITHTGPGVKRSGMTLTWQAPTESVGNIRFLLSVARNHDVYWVRMESNTLSASASLSAVTMPILVFLLGVTMATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHW6</accession>
    <name>A0A914AHW6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neurexin IV</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063307.1">
        <property type="nucleotide sequence ID" value="XM_038207379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207379.1">
        <property type="protein sequence ID" value="XP_038063307.1"/>
        <property type="gene ID" value="LOC119733997"/>
    </dbReference>
    <dbReference type="GeneID" id="119733997"/>
    <dbReference type="OMA" id="WWIARDG"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037126977" description="Neurexin IV" evidence="2">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37646" checksum="6B87AF0249FEDB0F" modified="2023-02-22" version="1">MQQLQPTGLVLFVGLLATFTGQSSGQPALGEIYRLNGLQSDLQMDTFRHVGKLMNDQYRRLDRRLKAIGSRIRRAERDLGVDSPPDEPLGGPAFPNIPDEGPNNIGNRPGNIPDKPVPSPPPVGQIARTCDEIYRMGYRNDNEYVIDPDGQGLRTVPEFNVRCELSRGEGVTIVGHNYETEPVFVSGYEQPGSFQLQIRYTNADFEQLEALTQASASCEQYIKIVCMGAVLFRAQLRRGHRDYGWWIARDGTRMMSWGGVPSSPDSGQCACDLDGSCVNSHFKCNCDSNNKFWSEDSGFLTDKRYLPVRMVYLGDTGGTKEKSWLTLGELRCKGFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIA8</accession>
    <name>A0A914AIA8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063457.1">
        <property type="nucleotide sequence ID" value="XM_038207529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207529.1">
        <property type="protein sequence ID" value="XP_038063457.1"/>
        <property type="gene ID" value="LOC119734179"/>
    </dbReference>
    <dbReference type="GeneID" id="119734179"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="257" mass="30348" checksum="AB9E52B3623E9F91" modified="2023-02-22" version="1">MPDCQKDKRRDHSSSSRSRHRSRDGTRASSTRKGPSKRSETSRGKKRGKKRARKRKVSKAWNLYGYTADDIPAPEKSSGDVEHSSRQTDPNADERLSRTHQWDEDRTLRPQDCRDESGNCSEVEKLSRDNDGMFDWKRHRRELDAIFFRDDSIIKRKSEDYHDFWKFLERYQAFQFKLSASQPHRDKNDVQDKEKSVKSAVLRLPLIYDNVTLKLRGVEEAERRSKWLTSKKDDEDELTTKRIKKISKVLVTNPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIM4</accession>
    <name>A0A914AIM4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063401.1">
        <property type="nucleotide sequence ID" value="XM_038207473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063403.1">
        <property type="nucleotide sequence ID" value="XM_038207475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207473.1">
        <property type="protein sequence ID" value="XP_038063401.1"/>
        <property type="gene ID" value="LOC119734115"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207475.1">
        <property type="protein sequence ID" value="XP_038063403.1"/>
        <property type="gene ID" value="LOC119734117"/>
    </dbReference>
    <dbReference type="GeneID" id="119734115"/>
    <dbReference type="GeneID" id="119734117"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="432" mass="46040" checksum="F95B46CCE6718E04" modified="2023-02-22" version="1">MSGAVSNSLEGPDGGRPGWVAVLALWTNNLMVIGITKGLGIMLPILQIQLTSQMWIIGWIASLTTATSGFVAPFGGLVSRRFGAGYVMMTCGVMMSAAAIAGSFVENSLQLALLYTLLAGTAKGISNVVAKEAVGRCFTKNYATASGIARTGYSVGLIVFAPLVQLFLDTYGWRGTMLLVGAITMHSVASGAVMVATRQPELDQSNAYQTLPQTEHTNSPSAHESTLRSHCGSLWKFVSKNFEVGLLLNSRYWLVAVISCCTIYAYLMWIVYFVSQAQSNGFTLEEAGSFVTIAGIANLFGKISQGLITDRGVMSSWTLVAVCLVMSSVSYLASSLLTSYWPMMTSAVLILFSDGVLSCQTDVLVKQVLGVELLAGAFGWIGLKVTLLLVALGFLPGLVYDLTGSYTAAFLLIGSVQAVPLVPLLMLRYSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIT8</accession>
    <name>A0A914AIT8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063309.1">
        <property type="nucleotide sequence ID" value="XM_038207381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207381.1">
        <property type="protein sequence ID" value="XP_038063309.1"/>
        <property type="gene ID" value="LOC119734000"/>
    </dbReference>
    <dbReference type="GeneID" id="119734000"/>
    <dbReference type="OMA" id="QNHELEN"/>
    <dbReference type="OrthoDB" id="7697851at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="370" mass="42301" checksum="5EAE228D035DC395" modified="2023-02-22" version="1">MELTCFKCNRRIRVNEGTKELAVHLRWVHGIWGSTEERLICCQNGCMKTFTLMNSFLRHIRLFHMFAPIIKNPNGQEIQNHELENDEHNAGSDSEPEEEDQDADDPEQADIEYFNNFDEDLVKQVAALLIVKLRSSASVTFSTRDKVINGTKVIFSNTLQALRQHTLSVMQNHGIDPNADDVQELFGKFSSLENPFSGLETPHQQMNYMLDRLLLVPPVETALGTRIDQAVDRKTGQTIQKLVTETFQYIPVLEVLKLVLNEQVRQLVDSEKKSPQGYFIGYQDGYSAGQHGFLIDHPKALRFQLYYDDVEVVNPLGSKTGIHKLGLFYYSIQNLPHHYNSSMNSIFLLVVCYSADLKKYGFAPIFETVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJD6</accession>
    <name>A0A914AJD6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038063832.1">
        <property type="nucleotide sequence ID" value="XM_038207904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJD6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207904.1">
        <property type="protein sequence ID" value="XP_038063832.1"/>
        <property type="gene ID" value="LOC119734407"/>
    </dbReference>
    <dbReference type="GeneID" id="119734407"/>
    <dbReference type="OMA" id="NECTDRS"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000626">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000681">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="238"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="50780" checksum="15915658CEDF32C3" modified="2023-02-22" version="1">MAAPTSKTSETKVDEEDHTETEEESTFASLGVVDVLCEACERLKWKTPTKIQRESLPLSLKGRDIIGLAETGSGKTGAFAIPILQALLERPQRLFALVLTPTRELAFQISEQFEALGSGIGVTCAVVIGGIDMMTQALQLAKKPHVIVATPGRLVDHLENTKGFSLRALKYLVMDEADRILNMDFEAELDKILKVIPKERNTYLYSATMTKKVAKLQRASLKEPVKVEVSSKYDTVEKLQQFYVFIPAKYKDCYLVYILNELAGNNFMVFCSTCNNTQRVALMLRNLGMTAIPLHGQMSQSKRLGTLNKFKGKSRSILIATDVASRGLDIPHVDIVVNFDIPTHSKDYIHRVGRTARAGRAGKSITFVTQYDVELYQRIEQLIDKKLPLFPTEEQEVMLLMERVTEAQRFAKLEMRDYDDKKKGRGRGGEDDSEDAVGIRKKLKMSHKGNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKI5</accession>
    <name>A0A914AKI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063929.1">
        <property type="nucleotide sequence ID" value="XM_038208001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208001.1">
        <property type="protein sequence ID" value="XP_038063929.1"/>
        <property type="gene ID" value="LOC119734472"/>
    </dbReference>
    <dbReference type="GeneID" id="119734472"/>
    <dbReference type="OMA" id="CTTTAPK"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="175" mass="20221" checksum="EE4A681000954DFE" modified="2023-02-22" version="1">EVMLKNGRELGEDSTFGTAMVEMGESLRQLSEVKDAFDLNVRQNFLDPLDHLKNKDLKEINHHRKKLQGRRLDFDYKKKKQAKGSTIPEEEIQFAEEKFHESQELAENGMRNLLESDVEQVLQLQALAEAQLEYHKQSAEVLESLLSTLNERVEEAGSRPKSERKPRSTFNSYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKU2</accession>
    <name>A0A914AKU2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064049.1">
        <property type="nucleotide sequence ID" value="XM_038208121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208121.1">
        <property type="protein sequence ID" value="XP_038064049.1"/>
        <property type="gene ID" value="LOC119734585"/>
    </dbReference>
    <dbReference type="GeneID" id="119734585"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="40" mass="4120" checksum="B82C2F989FAA2BD5" modified="2023-02-22" version="1">PTTTVEPTTTVAPTTTPEPTTTVEPTTTTVESTTTVEPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALI1</accession>
    <name>A0A914ALI1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Telomere length regulation protein TEL2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064411.1">
        <property type="nucleotide sequence ID" value="XM_038208483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208483.1">
        <property type="protein sequence ID" value="XP_038064411.1"/>
        <property type="gene ID" value="LOC119734875"/>
    </dbReference>
    <dbReference type="GeneID" id="119734875"/>
    <dbReference type="CTD" id="9894"/>
    <dbReference type="OMA" id="FYPQNYF"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000001">
        <property type="entry name" value="Telomere length regulation protein TEL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="6">
        <location>
            <begin position="350"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="5">
        <location>
            <begin position="536"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="96869" checksum="8D44A390F26F7D8B" modified="2023-02-22" version="1">MWNCTGIGMADIKLSVRQLVRESQNVLASSRDSSELCRALEDILPLLPGKKASVKDAPDMPQGEAVEEFGACHYVRFLEFLVGQFSLDWCGRFAADERQRLLDVFFLDGIHHHAFLVLCSTVKHSSPSFKQNKCLSLLEDFLLRGRMSDLIWAQCCVLSDLTDSGSQSTKHRILWEQLLTAIVTLPDRIANKVQGKCSACFFPKQYFTSLAKDLLVVLHKVHNQLKASKDCSLLFVSQLMGRICLNGHADTTFTFLLPHFVKLTAVDFLWSRVCSRVIVGTPERCLESVLDCLLKKIPWYGIMSRLLGDALLSNKKLLFLLTNKFLLLRCYNQELVPQNIIGYLADSPNRRHLVVKSLKTLLDVWGDSSAVKHTSYDQHAYLTKTILICLGHLNQQEKTQHKSVLMQKLLSGMHCHLNSPLVKVRRLGMITAEALTKTLETEGPKLSFEYVKDEESRLLLLLLVPPDDPGMDQITKDVVEMSLGEEETREEATSNQTEQEDATGQQSTPDDDLDSDDDLEPFDMSEDVKTSQVKTPVYIRDCIEGLHAKENRELTETSLKVAEKLVRSKPDYLQEVCVELMQVLLHLEDVFEIDDFTVLRHSAMVAATVQCPIQASQYWTAEFYDRNYNIRQRLDMLQVLAAAAQELSQPLEETTPSSGLQKPCRPLTRASPNPSEEAEHWRDIVQKRIKSKTRRFAKGRSTPAPTPVANRFAPVAGRFFFPLLKSFDSKMNTMDMIGDDFLLLGRMLFTLGIVVHAAQHAPICRQMAVSLLELVWVLRYHTEVFVRQALMFAVSMVILSVPSHLLVSDLQDEMLECKLWLEDIVGKDPNVECRGLAAQTLMVLGSVVQKELSAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANS8</accession>
    <name>A0A914ANS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065146.1">
        <property type="nucleotide sequence ID" value="XM_038209218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209218.1">
        <property type="protein sequence ID" value="XP_038065146.1"/>
        <property type="gene ID" value="LOC119735506"/>
    </dbReference>
    <dbReference type="GeneID" id="119735506"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18412" checksum="F67D9DDBA6295A88" modified="2023-02-22" version="1">MDVGHAVHAVDPACGAWLLGKIVGKNESQLQIKWRDYPKVEPSWIAKENVRAPEKRRQLRREIKVDQWPSLKAPRNLQRGDSVLSVREDGTPGEPFVVEVNDGFMCEVLTTTGRVLRYEFIKETTRGTALPIQAGTSSASTQPPVTVSVFCHNFWTTAKSSDNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP02</accession>
    <name>A0A914AP02_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038065755.1">
        <property type="nucleotide sequence ID" value="XM_038209827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP02"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209827.1">
        <property type="protein sequence ID" value="XP_038065755.1"/>
        <property type="gene ID" value="LOC119735882"/>
    </dbReference>
    <dbReference type="GeneID" id="119735882"/>
    <dbReference type="OMA" id="MENIMNM"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="233"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="810"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="984"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="995" mass="112605" checksum="ABEA465A63AE5ED1" modified="2023-02-22" version="1">MTNKKPYEQRAHHLLDVTDDEPPQDITDDFTMLKHLEPEANTVNKLSVKPYQMELEINNSSITMELDTGSPWTIVSYETYKKVGKLGTIRPSKVSLKTYTGAKVKILGEAEVTVRYASSNPKVLPLLVVEEGVSLIGREWIQQIPLPLTEVLSRHAVKESTEGAATTNKLVTANLKEMLKSHEQVFDDSSLGHLQGFKAKLYPVDDAPKFYKAAPVAYAARQKIDKSLDEMLEQGEIEAVKFADYACPIVVAPKPNGQICICGNYKLTANKVLRLEQYPLSTLEDMMQDLQGGKKFSKNDLSHAYHQIELDEDARKYTTINTHRGLYQYTRVPFGLASAPALFQRTIESLIADIPMCRPYLDDIIITGRNDADNLANLEAVLQRLEKHGMKIKKEKCEFLRESVTYLGHSIDAEGMRPLEDKVQAIRLAPVPKNQEELKAYLGLLGYYRKFLPNLSTQIAPLTMLLKDEYKSGTKCKASQKTSTSPNFKWGPAQQQAFDTSKQLLESDALLVHFDPRKPVLLQTDASPYGLGAVISHEMPDGTEKPIAFASRTLTPCERNYAQYEKEGLSIVFGLKSFHKYLHGNRFRIVTDHKPLVSLFGDKPASPMSSARVARWHMLLSAYEYTIIHKAGRLHTNADALSRLPVESTVEEKIHWMHDILEDESAVKSRINLLDDVDGRPVDAQEVKVLTDKDPLLSKVRSYILRGWPEGHIKGEMSSYTTKQLELSLEDGVVLWDSRVVIPQDFQLRKRLMQELHATHPGIVKMKMLSRSNFWWPGVDKELETLVKGCKVCQESQKMPQQSPIHPWEFPERPWQRLHIDYALDEGREVLIVVDAHSKWIEAVPVNSASSASTIKVVRRMFASHGIPDVIASDNGTPFVSEEFFTFLTNNGVEHIQTVPKHPSSNGLGERAVQTVKNGMKKMKGCNLEMRLQKFLLQYRVTPQASTGKSPSELLYRRQILTKLDKLRPDLAKKLKRQQNQMKDQADRGSKPRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APD0</accession>
    <name>A0A914APD0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Nodal modulator 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065331.1">
        <property type="nucleotide sequence ID" value="XM_038209403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209403.1">
        <property type="protein sequence ID" value="XP_038065331.1"/>
        <property type="gene ID" value="LOC119735620"/>
    </dbReference>
    <dbReference type="GeneID" id="119735620"/>
    <dbReference type="OMA" id="FVFKGFG"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056191">
        <property type="entry name" value="NOMO_12th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056189">
        <property type="entry name" value="NOMO_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056187">
        <property type="entry name" value="NOMO_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23192">
        <property type="entry name" value="NOMO_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23193">
        <property type="entry name" value="NOMO_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23660">
        <property type="entry name" value="NOMO_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037403263" description="Nodal modulator 1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="9">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="11">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO third transthyretin-like" evidence="14">
        <location>
            <begin position="210"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="11">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="15">
        <location>
            <begin position="398"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="12">
        <location>
            <begin position="582"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO eighth prealbumin-like" evidence="16">
        <location>
            <begin position="712"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="10">
        <location>
            <begin position="778"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO C-terminal transthyretin-like" evidence="13">
        <location>
            <begin position="1038"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1208" mass="131405" checksum="5D178AD171954722" modified="2023-02-22" version="1">MGFLHEITLFCLAIYTFCSVTKADDFLGCGGFVKSDVEINFSRIEIKLYTRAGALKYQTDCAPNNGYFMIPIYDKGDFTLKVEPPQGWSFEPTSVDLHIDGETDKCSRGEDINFKFTGFMLSGKVLSKGQSEGPAGVSVSLQRKGGDAAVVQSQTSAGGGYTFKQVLPGEYTLEATHPKWTFVKASIPITIARDSSLPAPPIIISGYDVTGHVMSEGEPIKDVHFLLFSDTVSKEDVTQCDTTPVKGYTNAQGKTPLCSVTSTEEGKISFPSLPSGQYTMVPFYQGQHITFDVMPTSMDFSVAHDSVTLPTTFKVEGFSVSGQVLDSEGGKGIPGVKVKVQDRSEVTSKVDGTYQLVKITSGTYVLTASKDNIFFEPETMKINPNTPRLPDIIASRFSLCGRLVIDKMPPTLPSGGKRRVSLVPEGGSAKDTVSIATDSEGAFCFKVKPGSYVMQPTLSSEEMAAGLKIIPSEQKVQVKNAPVFGINFSQFKADVRGVIKCIDVCGTLQITLHSEAGMEERSPAQISQQTKQASFKLKDVLPGKYKVSVIQNHWCWETPSLDIQVTDSDVTSLEFTQTGYLLQCHVSHPIAMLYHHTKSPKQSKEIDLAKGLNQFCLERSGSYQLTPLSCHKFDQESYNFDTSSPAMLALTATKHLMTGAIVAKQPSSDITVSIRSSIEAEPLVHLGPLKSQKELEEEAKPKAKPTKKGKATAAEEETKVVEDTGPSVYEFTYWARNGERLEITPSSKVILFYPAKAQVTIQAGDDCLGKVVEFEGRAGVFISGQVKPGLGGVKISVTSRSLEDKEVRPAINIDTAKDGRYRIGPLPDTAEYDVQASLEGYVLTKVEGTVGDFKASKLGEITIQVVDEEDVPLQGVLLSLSGGTFRSNNLTQASGSLVFTGLGPDQYFLRALMKEYKFEPGSQMISVEEGSVIKLKIKGSRVAFSCFGVVASLNGEPEQDIALEAQGVGDCGQVVEEGISDQEGKFRIRGLQPECSYELRLKSGEANGHIERAAPKTQIIKVQGKDIADLHIIVFRRLNQFEIGGNVITPSEHLATLKVLLYSEDNLVSPVHTLSLGSSCFFQFPSLPNDGARYVMRLESSLLKSSWEYTLPEASFSTEGYFKHITLQFNPERRSVDQEVSSGSHLALPLIAALIAIGLNHAKLLPILQQLGQNLKGLRSPGSAEGRDMGGAGDQDTRPKKKPKTRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ16</accession>
    <name>A0A914AQ16_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065504.1">
        <property type="nucleotide sequence ID" value="XM_038209576.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065515.1">
        <property type="nucleotide sequence ID" value="XM_038209587.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065524.1">
        <property type="nucleotide sequence ID" value="XM_038209596.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065534.1">
        <property type="nucleotide sequence ID" value="XM_038209606.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209576.1">
        <property type="protein sequence ID" value="XP_038065504.1"/>
        <property type="gene ID" value="LOC119735707"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209587.1">
        <property type="protein sequence ID" value="XP_038065515.1"/>
        <property type="gene ID" value="LOC119735707"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209596.1">
        <property type="protein sequence ID" value="XP_038065524.1"/>
        <property type="gene ID" value="LOC119735707"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209606.1">
        <property type="protein sequence ID" value="XP_038065534.1"/>
        <property type="gene ID" value="LOC119735707"/>
    </dbReference>
    <dbReference type="GeneID" id="119735707"/>
    <dbReference type="OMA" id="GANRESH"/>
    <dbReference type="OrthoDB" id="5979770at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038868">
        <property type="entry name" value="RAP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15932:SF2">
        <property type="entry name" value="BRCA1-A COMPLEX SUBUNIT RAP80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15932">
        <property type="entry name" value="UBIQUITIN INTERACTION MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155521" checksum="A00C6C263B76B775" modified="2023-02-22" version="1">MGKRKVALTFAETSLDGDEDLKPTRRSRRVGNTHPQQTEPNKADSADSDDVHDFVTLPSTTTAATASTAPSTSLPAQRGQRKQQRIQIVEEQQRQAVQRNDEVLRQQEEDDIMRAIELSKLEMEAEQQCSESREEWGSALPPDPQEPCRDSQSPQPLRKSFSSRAEAADVPPQEEFLENNTTESLSSSSSVVSTDCEEGTSPEKVVQTRTDNCTEWQDVIGSANWEDSSPSAGVANCDRGTQPMDNSSETGGQNRSQGGQNGSHRGQNGSHRGENSQYQSASHTITSSQPSQDSRRKRLRRPKRHMEEEVDSPRQEQPAKVRKVPTPPDLDETEEEEEDEEIDVVNEGEAMSGQEDLEEYQQLSPMHKPRKVYKLVDTRKPHCLKHPFYAPHNVGKRSYTRVIYQLIQAYCFQLRRAQAKVLTRVCWGNPIVTGNCYSDTLVQRKRGSRACTFYALSDSDEDGKASEAGTEAEAPSKGKLQRRKKKLAVDAEDDADSDFEDFIPAGRRKASTQRRPRQAAKDVVEMLMQDGRCFLEERPDETLSPTLVEDQIETQDFTTAPGDGCMNKDSDLSQPIVRETLSSQGINNQDDSKKSPHAHADSQSSLTDIFGASSNNETDSGKNAVTSSHQSSRSPVTSPRIDSSHRTNEKSENSCEEDSFDEEILTLSTPKLQSRAESFKTCLQKDNSQTKSVEPTQDRHYEVRPLVSFQQGEKDEVSSLRDSSPPTVGPLDASQNYLLPQQSDSTQSLSFEELRYQFYLSEPALVRPKRFEEKTEGGEYVVDLDNLSQEARNQKSMEHPGADRLEEQSPQTKDISTNIRLNVGQGLENHNKIANGLQDSMHKRRSPPSVNKQSSLINNRRATDDEEEITDCESPTDRDSQYNSCRDTRQSEPDEGWDGSGNGPKGDDDKDYDEELKDFENQEDAERSQGEVEENVHSGDDADATVRAEWEEEQDEIPAMEMREAMDAANEEVSPHQGDRHEEGDYGLEEEEGIITDEDREDDAVGETHHSSMIGVECPLCSVTYHIDQIEAHASGCNGPTSPQQEDERLGLAQGPREPTVGVTAGMALGQQHVYNDRNATVPNNNEGLAGPSTAGTQHHRDQTANDKSKSRPMRGVAAKIVREDAPKHNRNPIQDSVIRKRSDPDHGLDEESSESCSESADQLDASLLQLVEDNKLQLRERKRTRAPDRPAKRQKLSSADKRSEASKDSEATELCFLCHQHISKSAYAEHVQEEIDRAEAEKHLEDTSVLPRRGLRSRTTAPNAAGGESSREADRNTDQSGTTSGMSHTAGDFSSWDGEPDGDSDSDDDSSQTVQEDALFNPRLSESPIKAFRPISKQPMNLIDFKNQFNSTGKTARTGVTSRSTSGKRGRRGQGKGRRGGKRKQRKKRGRSFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATI4</accession>
    <name>A0A914ATI4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067082.1">
        <property type="nucleotide sequence ID" value="XM_038211154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATI4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211154.1">
        <property type="protein sequence ID" value="XP_038067082.1"/>
        <property type="gene ID" value="LOC119737073"/>
    </dbReference>
    <dbReference type="GeneID" id="119737073"/>
    <dbReference type="CTD" id="84240"/>
    <dbReference type="OMA" id="RLKRQEM"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="297" mass="33399" checksum="FC1B28630345193F" modified="2023-02-22" version="1">MTRYARGNKGNRKRPHEASSWSDLKTEDANHQQQKTKDNGDDTPKGKDQTSVKTSKRRKQKSKLRDKGISLDEHKSILKKPQKSKGDELQQEGTGSLHSSLSERLTSWSDAKSAEETERKLETDKKKDKRREERRLKRIKKKSNKMVCYHCREAGHGVADCPKMLLDEEQGTGICFRCGSTEHEASKCTAKVDPSKGDFPFAKCFICQETGHLSNSCPDNPRGLYPLGGSCKHCGSVEHRNQHCPHGLDAQKQTSDTTLPTLSSTLSWSADAEIDEIKPRPTTARQPIQKTPKIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATM9</accession>
    <name>A0A914ATM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067410.1">
        <property type="nucleotide sequence ID" value="XM_038211482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211482.1">
        <property type="protein sequence ID" value="XP_038067410.1"/>
        <property type="gene ID" value="LOC119737274"/>
    </dbReference>
    <dbReference type="GeneID" id="119737274"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="11">
        <location>
            <begin position="85"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="267" mass="30913" checksum="22E1807080A3D4A9" modified="2023-02-22" version="1">MASMLVKPVVTFTKNLVRKQGRHGALFCQLATRNLCSGSSVKPTVRVRNELQANRLADYGKYVADCLPKYVQQVQVSHTNELEVLINPEGIIPVMTFLKDHHNAQFKSLIDITAIDVPTRTHRFELIYNLLSLQYNERIRVKTYADELSPVDSLVPVFEVANWYEREVWDMYGVFFSNHPDLRRILTDYGFEGHPMRRDFPLSGFVEVRYDDELKRVVCEPIEMTQEFRKFDLASPWETFPDYRDGAAQLPATSEQKDTTEEKTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU23</accession>
    <name>A0A914AU23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066809.1">
        <property type="nucleotide sequence ID" value="XM_038210881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066810.1">
        <property type="nucleotide sequence ID" value="XM_038210882.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066811.1">
        <property type="nucleotide sequence ID" value="XM_038210883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210881.1">
        <property type="protein sequence ID" value="XP_038066809.1"/>
        <property type="gene ID" value="LOC119736872"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210882.1">
        <property type="protein sequence ID" value="XP_038066810.1"/>
        <property type="gene ID" value="LOC119736872"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210883.1">
        <property type="protein sequence ID" value="XP_038066811.1"/>
        <property type="gene ID" value="LOC119736872"/>
    </dbReference>
    <dbReference type="GeneID" id="119736872"/>
    <dbReference type="OMA" id="EFNGRCA"/>
    <dbReference type="OrthoDB" id="5843397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324126" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="37"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="142"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="374" mass="41333" checksum="960445EDDAF09CB6" modified="2023-02-22" version="1">MIQAHKANLWMVLVVSVMVIRIQARSKEDGTIFLERGNPGILSCPLVASGQIPLDQIEVMYWYFPRLRDEDILISYFLGNVAPQNGIPEGVYDINGNFSLVVENVTDSDEGTYYCRVKPRLRMLVDGHVTMRVKVSPKEPFPDVTQCTQRISETACKAELPNDIKKRRLTCIVRDAKPAVALRWLLEYSDGDTQLISDRFTVKPSAYSVNTFTTSASIPVVSSKVDTLYSCQAYGEALSSRNGSHVTVTAFYTLQTTHFKSIQPTAAVPAMAELGFNYTVEDTPYCSQNAVIGLTVALCLSLAVVVGLVIAVCKISMRKPGQKNDIELQNETRVRGNKGSKGEPQETCLDSEVTIPLKGENGHVCNLKKQANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUG3</accession>
    <name>A0A914AUG3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067154.1">
        <property type="nucleotide sequence ID" value="XM_038211226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211226.1">
        <property type="protein sequence ID" value="XP_038067154.1"/>
        <property type="gene ID" value="LOC119737124"/>
    </dbReference>
    <dbReference type="GeneID" id="119737124"/>
    <dbReference type="OMA" id="MDSLMQD"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="56674" checksum="448B1D622B744565" modified="2023-02-22" version="1">MEKKEANLPSSNVPGFLAKLWLLVDDATNDELIGWGPSGNSFVVQNQTHFAKDILPKFFKHNNMASFIRQLNMYGFRKKANLEHGCLKLDSDEIEFQHPNFVKGRTDLLENIKRKVSAREENKLKYEDMHQILTDVQDMKGKQENISGTLEAIQRENEVLWREVVYLRTRHEKQQKIVNRLIQFLITMVKPVGLKRKQPLMIEAASDPSKPKYSRLANPGDNIQVIEPVSFDTDIATLPEVGTLPSGAVLSDITDIPSTTGQPLSSPGIEPGMAAVSDQTPATLDPSLFELDIPPATADMAQAVTSPMVTSPAGLEPSTSDLALPSGGDTGMFGSTAWPLQETDGQANAGMASLFDTDDDEQGEGIVGNGLGSPLGQTSGMTSGSGSKAIMKRMLSHDEQRGEIGEHVNTVQENLDLIQHMLTSIGSATPYNLDMDSLMEIFNSENSGNTNETDLFPNMAVSHSQSNEDGDQENVKGNEVVQYVSSSSSPAFTVEDEDSLLRSLDDDAAALASPNNRPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVP4</accession>
    <name>A0A914AVP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067326.1">
        <property type="nucleotide sequence ID" value="XM_038211398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211398.1">
        <property type="protein sequence ID" value="XP_038067326.1"/>
        <property type="gene ID" value="LOC119737209"/>
    </dbReference>
    <dbReference type="GeneID" id="119737209"/>
    <dbReference type="OrthoDB" id="10176605at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037308776" description="Spaetzle domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24762" checksum="982B40BD1D4EAD3A" modified="2023-02-22" version="1">MLLFFVMSAVLCHHISQANHQYFVGSDSKDAYPACSISDCLAYINFRETLHLTYFQKQQVNYRRNYLRSVHSRLTSAGAGARRHGQRVIEITLEQQAKILAMYGNYFTKRGDLPVQNSVQKRDVDICPRVQSWDDLILRLTNDDELIQVVQFDNDDRQWILEESCSQSTCSFVPQCACGTWTRLVRALVVNFDETIIEEKYIKVYCCIAKKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVT4</accession>
    <name>A0A914AVT4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038067872.1">
        <property type="nucleotide sequence ID" value="XM_038211944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211944.1">
        <property type="protein sequence ID" value="XP_038067872.1"/>
        <property type="gene ID" value="LOC119737520"/>
    </dbReference>
    <dbReference type="GeneID" id="119737520"/>
    <dbReference type="CTD" id="4507"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000012">
        <property type="entry name" value="Probable 6-oxopurine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="30615" checksum="02F6C6CAD2EB39F2" modified="2023-02-22" version="1">MHNALSILVGIIGGTGLDNPDIVQDRKEKTVVTPYGKPSDVLITGTIGGVDCVLLARHGRGHTIRPTDVNYRANVAALKEEGCTHLVVTTACGSLQEDIHPGQIVILDQFIDRTTKREQSFYDNAATSPKGICHIPMHTPFCEKTRQVLIESVKHLGYKYHPTGTMVTIEGPRFSSRAESKLFKSWGGDVINMTTVPEVVLAAEMGLCYGAVALPTDYDSWRDEGNEHVSVEVVMTTFKQNAEKGKKILQDAIPRLAKYDWKPVLEERVVTAKESVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW07</accession>
    <name>A0A914AW07_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068285.1">
        <property type="nucleotide sequence ID" value="XM_038212357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212357.1">
        <property type="protein sequence ID" value="XP_038068285.1"/>
        <property type="gene ID" value="LOC119737768"/>
    </dbReference>
    <dbReference type="GeneID" id="119737768"/>
    <dbReference type="OMA" id="IVCRHSN"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15440">
        <property type="entry name" value="7tmB2_latrophilin-like_invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000200">
        <property type="entry name" value="Adhesion G protein-coupled receptor L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048072">
        <property type="entry name" value="7tmB2_latrophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="16">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="479"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="690"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121010" checksum="29D2CDE39845848C" modified="2023-02-22" version="1">MLNTDLTTQSRMRLEAAACGRQLYFACELTVEALYQERTFQCLCPEGYSGEFCHHTSDLQIQESCSDSLLVLTCDHDKHLSIVGSTFHLDNNNVCPPAGVAPVGNCLFSASQINTYLRELILLPGCEGQTRCEVTVTDDLIRDLDPCPTHPKYVKVHYRCRDTYNVHTETCQSLTAKLSCQKPLGLPHIRVDVAAYGRLRASSVCSESTLRPGELSVTDCRSLMTLDIVARRCNGYASCNVTASDDVFGDPCQGVFKYLDISYQCLANITEATAAYPLTYGVATLTPPVFCPAVNRSGVQWRTTQDGKTDVQRCPDGQDGLAYWQCDKQNPVQWSAMGPDLSQCTSPWINDIYRQIESESVSAGVLAQSVLNNTVASSTVQNRDVQKTVSLMNDLLQLQDKQLTGLAEQEQQSTVEAFGEILVEFGSNILDSDKQSTWASAATDEGSAASQTPATPTDVTENLENTGFLVAQYLSRDKTNVVIHSENIVMTVEAIASENAGKAVFFQDTRTTEDGTTDTLNTITLPPSATQTTGNMGSAQVVFLVYKTLGEYLTDTAIDGMEAISRSVNDTDYDFSNETDESLGLQLNSAVMSASARKQEKDVETFENDEEVLLTIKHTLSNITGNVSCVFWNSSKSLGGNGAWSDKGCRLVSSNQTHSACACNHLTNFAILMDVTGTHTKIPVIHEKVLTVLTFVGCSISIVCLFISIFAFTFFRNIWSLRVTIHRNLCLMLLLANALFIAGVEQTQIKILCSVIAGLLHYSFLSAFVWMSLEAVQFYIMLVHVFSTHSRHWPYYLAGYGIPAIVVGVSAGVNYTGYGTDRYCWLSTDNYFIWSFTGPVAAIIAVNVVLLIVSLRIAYSSRSSINKGIAQNDIRPWIKGAMTLLFLLGITWGIGFFFINQQSLVVAYIFTILNSLQGLFIFVFYCLGNERVNSEMRKFVHRQRWLPACIRDRYGRNSASNQSWSQKGATIRRQQACRPEVYHKTDTSAMTTLNTLSEGDITETTKDKYANPAIDVKLVDDNDQDNSSQTANMEYGTTNMAYDTSSLAETCSTVAEGTNIADGSHSGRSWLHNNAINTIVAENKTKSDHQYPPVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWQ2</accession>
    <name>A0A914AWQ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068540.1">
        <property type="nucleotide sequence ID" value="XM_038212612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212612.1">
        <property type="protein sequence ID" value="XP_038068540.1"/>
        <property type="gene ID" value="LOC119737933"/>
    </dbReference>
    <dbReference type="GeneID" id="119737933"/>
    <dbReference type="OMA" id="CESRIDG"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037103318" description="Fucolectin tachylectin-4 pentraxin-1 domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="9">
        <location>
            <begin position="208"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="353" mass="37729" checksum="A247476F5BAD4A26" modified="2023-02-22" version="1">MRMFRWLSAAVLVLGIVGCQIADAMNEVEMELLERVLERAEEKEVAGGQPLSIVDKVTWQSSTQGSYLYPSSKAVDGSSSAILYPDAKCSHTAGNSKNPWWMVDLGEEHCISKVRILNRGDCCSERLAGANVRAGNSPTATDNPTCGSHVTAAQANPHGGTIVFDCSSPLRARYISVDIPRTGTLQLCEVTAEEVPLDQCATKRFGIVGKPATQSSSHGSGLYPAGKAVDGSSSTILYPDSHCSHTNNERNPWWRVDLGSQQCVTKVTILNRGDCCSERLKNAIVRAGSRETVIGNQACGAPITADQAQPLGGTIVVECGRPLRARYVSVDIPGTATLQLCEVYVEVLSSGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWV6</accession>
    <name>A0A914AWV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068004.1">
        <property type="nucleotide sequence ID" value="XM_038212076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212076.1">
        <property type="protein sequence ID" value="XP_038068004.1"/>
        <property type="gene ID" value="LOC119737613"/>
    </dbReference>
    <dbReference type="GeneID" id="119737613"/>
    <dbReference type="OMA" id="DVYVKMP"/>
    <dbReference type="OrthoDB" id="20889at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47824:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="194"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57274" checksum="59BDFB7B125BF3D5" modified="2023-02-22" version="1">MLLDVYIKLTSGRVFHMPVSAYETVRAVCEKVATEEGVSASCLRLKYTGKVLNKDHTMDYLGVRPETILKADIIQTKSLTILIKCPTGETIPLTIQNITTLSEIIARIKDKQNKQGPTDSKIYKLKLKGKFLSGDRTLAEDLGIEDEGVLELVEQAAAATYNEEEVVEEELDQATLDELLANFADGLDKNRKVEVVFSFDTTGSMYGSLSEVRNKLDTTVSRLLRDIPSIRIGIMSHGDYCDQNIYVIRSIDLTSNTDDLLGYINNVPRTGGEGPYACYEWVLHKAQELSWSEDAAKALVIIGDVKPHAVSHTDQRINWHEELDKLCKMDVKIYGVQVTNYGSDKYFYKEMAARSNGAYIKFQHFNYLTDMFLAVCYREAGEEQLQQYAEEVKQEGRMTEELTDMFTQLEENPTKSAMEKSEDDTEENKEDDGPRYVQEPWWDPELDHGQPVYTYSLEEDCWTRFGTSFSTPAAGSAQLNNQTGSRIRRSMRWKGKKGSKRCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXD3</accession>
    <name>A0A914AXD3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068353.1">
        <property type="nucleotide sequence ID" value="XM_038212425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212425.1">
        <property type="protein sequence ID" value="XP_038068353.1"/>
        <property type="gene ID" value="LOC119737809"/>
    </dbReference>
    <dbReference type="GeneID" id="119737809"/>
    <dbReference type="OMA" id="WPHIRVE"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="154"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="257"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="358"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="655"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="890" mass="96887" checksum="CFF825289E460762" modified="2023-02-22" version="1">MFEGKLDNMAGIMDVRLQIAWQLLLFLGQCKEKCLAFEGGRSTFAGDGTTVSSILATHETVPSVALEFNSSEPAPDSIKFTWNTIPYDSTDGNIWYQAQLTHSGREIGWKTVITESVTFDGLLPCSLYTLQVWPHIRVERGPPMLVQQRTNTIVPDAVKGLSFTVFRYGQLNVKWKASTNPDNSCRATDFLVTYELTNLEQCQEMQGNIKTRSTSRTAISIQGLKAYSTYNVTVTPRNEAGLGQSRSKQTQTGRTVPVATPVNITSVATANSLSFGWDPVPCGRRGGPLTGYSYRFGKSGSGRPMTSRDAGSDSATFLSLPACTSYWFKVRAYSSAIWNFGPWTDETQADTQMIVPDPVEGLTLTPLGHDRLVVRWSASSNTNNNCHATDYHVTYELINLEQCHETLDHNVSTINVSVTTMTINGLHAYSSYNVTVTPRNEAGYGPVLYQTVQTGERKPTGTPILGESTASSDNITFTWSQVPCGGRGSATTMYRYKFMKRGNTIAIEKDDTTAMSVTFRGLSPCTSYAFVVRAFNSKGHGPWTDESYQDTAEIHSLNLEPSTDEIKVSWTTAGNEDNPCPPVTSYRVSYQLLNLEQCQQMTDPALIHAAVVDGSDIDLTSMHTYSTYIVQVAPANNAGAKYMKSKTVTTEEGVPLAAPKLDNVFWSNRSVRMFWHPIPCGKRGGDITGYAYELRDASGSIIQTADTTAESVEVDGLSQGGSYSFRMRAFTRVGPGPWKEVDFDIPTVDTGARETSGSGVAGPAFIGVGLALGIIFSAAVAVLVAFARHFRIRCLQTMRPDGTTSPNTGGPDNADAIYFDINDDVELKKMSATPSRESATGASTVPSGKSTTRVSAPRASTKRSTTKATKKTKMADGQSGARHYENTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXW4</accession>
    <name>A0A914AXW4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068349.1">
        <property type="nucleotide sequence ID" value="XM_038212421.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068350.1">
        <property type="nucleotide sequence ID" value="XM_038212422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXW4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212421.1">
        <property type="protein sequence ID" value="XP_038068349.1"/>
        <property type="gene ID" value="LOC119737807"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212422.1">
        <property type="protein sequence ID" value="XP_038068350.1"/>
        <property type="gene ID" value="LOC119737807"/>
    </dbReference>
    <dbReference type="GeneID" id="119737807"/>
    <dbReference type="CTD" id="203228"/>
    <dbReference type="OMA" id="QPFYTSV"/>
    <dbReference type="OrthoDB" id="10252077at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="53213" checksum="385E36955F80EF7A" modified="2023-02-22" version="1">MASFSDDEISPISQKMVFVVDTDRHGPQDYRDSHTLPDTADCPVYALVMGCWNNILGPHAKYIWLTEGKPNFTPDHVSYLSTHTLTSCEQPQSTIDTKVLILPDRGIVVTVFLFSGHDGDEKTIFALSLVIPYEEYRWYLPLHELCVARLTTMIRRLRVLQEKNKDEYNDSALEAFSEEVPSFIRVVTLLKTHGLPSRVALTDTVFAPGHIKQLDNQFTKVAIASHLQTCGCSIVIGNTPADVNVMISTLALFLSPSERRCCLYLDNVPRIYQKDVLIQGFIKDSINLDDYLRVIMTSQYPTTLIDMTTLEVRQTLHYNEHAYRRHVLTSQELQSLWLGSDEPLRYSPVVHFSKKPEAEAIVQKFWKEIYRLKEKCSVRETYVEEFLRLLDRQAVSLIKYVEEETNRGTKPSRLVLKRLKTDLHLIPEGNFRLVLAVAEKLKPGIYTMVCGNPALPRDSYNDLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY40</accession>
    <name>A0A914AY40_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068617.1">
        <property type="nucleotide sequence ID" value="XM_038212689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212689.1">
        <property type="protein sequence ID" value="XP_038068617.1"/>
        <property type="gene ID" value="LOC119737990"/>
    </dbReference>
    <dbReference type="GeneID" id="119737990"/>
    <dbReference type="OMA" id="RMAPMHW"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="42435" checksum="461E099502D7EACF" modified="2023-02-22" version="1">MKIEKSSTKVRFGTLDPRKVEDVTKSVLEHGRYRNPRSWDTWRQPSFITAIKLMFTRSQNGLPSKQELERTLPMNVTNGTVIGSPPDSGIKVTWFGHASLLVQFDGVSILTDPIFSSFCGPASLVGYKRYRPAPCTVEELPKVHAVVISHSHFDHLDLPTVKQLNRKFKSDLRWFVPSGMKSWFTRAGVEDVVELIWWEDTCNYIQLGRDTSTRVRFFFTPAQHWSMRNGIDTNKSLWGSWSILGPNNRFFFAGDTGYCSNVFKEIGQKFGPFDVAAIPIGAYKPKALLSPQHVDPSEAVQIHSDIQARHSVGIHWGTFELGKEHYLAPREDLKKALEKARLDGHNIDFFTLQHGETMLLADKKTGNREGGGESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZD0</accession>
    <name>A0A914AZD0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068874.1">
        <property type="nucleotide sequence ID" value="XM_038212946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212946.1">
        <property type="protein sequence ID" value="XP_038068874.1"/>
        <property type="gene ID" value="LOC119738191"/>
    </dbReference>
    <dbReference type="GeneID" id="119738191"/>
    <dbReference type="OMA" id="KGRTECI"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="693" mass="77262" checksum="9B88F4DB4B38BE2F" modified="2023-02-22" version="1">MARWLTHCHQVHVRDVGRKALDLLTEGLGSCSGVTNTMRTPCNTRLVNRLRTRWCSSSSAASTMDYLHALSPVPTMIFQPAIPQVPIPSLQDTCQRYLASQWAFLNPREFAETKTLVGEFEKGAGVDLNNELLELNKKNSHTSYITDFWMDVYLRYRDSVILKTSPMTFITNDHRPEYMDQTIRATNVIVSLLRFLKTLREDKLFPDVVHKNPAVTDTEGFWRSFRSLSAEDAYRHAVDSSVQPLDMSQFTRIFNATRIPRNNRDELYKDDTKRHLLVIANSHMYVLDVLDSDGSLVPGQDIRANLQYILNNSSSLPPPEHPIGYLTTEHRDTWTRLREKLLAVCPDNEETVRLIDSALFCVCLEDDTDDSKEQLARKGLYGNAGNRWFDKPFQLIVTSDGQLMTNIEHSWGNGVTLKRLFTDAYEDAVSRPAITPGGTTHTSSVDSSKSVSKLEFKLDSALCQGIEEAKANHALATSQLNVQWVQYPRYGSSFMKKCGVSPDAVAQLALQMAYHRVTGGVAATYESCSTSMFKHGRTETIRSATAETKSCTEAFYKNSGVNMDEKRSLVKACSDKHRLLSKEAIQGQGWDRHLFALRCLATVTGRPMPAVFQDPAYANINTITLSTSTTGISKSSAGAAFAPVSPGGLGVAYTVTGDGVSWMGTSYSASPSLSDFARSVHEAYDDLYEVMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZG5</accession>
    <name>A0A914AZG5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069063.1">
        <property type="nucleotide sequence ID" value="XM_038213135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZG5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213135.1">
        <property type="protein sequence ID" value="XP_038069063.1"/>
        <property type="gene ID" value="LOC119738293"/>
    </dbReference>
    <dbReference type="GeneID" id="119738293"/>
    <dbReference type="OrthoDB" id="5797898at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037249050" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="241" mass="27640" checksum="A6DF5287A395EFD6" modified="2023-02-22" version="1">MSWFSATLISILFLLLLVSNRSFLQASCPPGWLKWRQSCYIRLPNRMNWFEASEACNRPGGSMIVPNSKEENLFIWESLVTGTGGLWIGCTDAAQEGVWLCDGQPAQYTNWHPSYPSRSNKRNCARISTYEGWRWVDKTLCNRQRFAACEMTPSSVPAYHTFTGPDGRVPQRCLLHHDIKNLTAEGLLACGWACWADPRCRSFNLWQSKKKQKMCQLNDVTRLVADDNDFKATDNCYFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0F2</accession>
    <name>A0A914B0F2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038069378.1">
        <property type="nucleotide sequence ID" value="XM_038213450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0F2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213450.1">
        <property type="protein sequence ID" value="XP_038069378.1"/>
        <property type="gene ID" value="LOC119738543"/>
    </dbReference>
    <dbReference type="GeneID" id="119738543"/>
    <dbReference type="OMA" id="YDFVGHY"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="352" mass="40539" checksum="3BB5236E38969E3E" modified="2023-02-22" version="1">MENTSAKIGDSQALTKDGDTFWTNAKKEDSEWHTDDRAALETESYRYLHHPETVNETYDVWWTQTLRRKVLRETCDSLVDLETSSSAPGHLLVDDRNRFLFCEIRKVSSIAWRRVLDAVSSVNNSSATGGGHRRSRTGGLRRLGTYSAEERERRLREYTKFLFVREPMLRLVSGWRDKFVAGPQRRDYRSSWGPRIRRYYNSQLTRHSSASQDTGHQPSASVEDVEISFPEFVKYLTAGPPRSPLMRDMHWEPYRSRCRPCLVRYDFVGHYETLGPDAAAILPVLNRWSAGGGSVDFPIRRSDSLGVAQTEFPKLAPEDIVKLAKLYDVDYKLFGYSMSQFMSWLQKNSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B263</accession>
    <name>A0A914B263_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069591.1">
        <property type="nucleotide sequence ID" value="XM_038213663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B263"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213663.1">
        <property type="protein sequence ID" value="XP_038069591.1"/>
        <property type="gene ID" value="LOC119738728"/>
    </dbReference>
    <dbReference type="GeneID" id="119738728"/>
    <dbReference type="OMA" id="RFKERDS"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008069">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01686">
        <property type="entry name" value="EP450ICYP2D"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55907" checksum="A67A4A84F9E21AFE" modified="2023-02-22" version="1">MEAIDGMMALDARSVLIGLVVFLVLYRLLRRTPRNLPPGPTGWPVLGYLPQLAMAKEDPQKIFSKLAAKYGDVISVNVAGNLLVVLHGVDAIKEAFNQPQLSARPKLHVSEKLRPGVGIFISSGEIWTKIRRFSLTVLRGFGVGKSSFEENIATEAKFLIEEWKKEAGTPFEPRHLISRSVSNVICAVVFGERFQYTDEMFRRLIHCTDDVFEKIGAGGAIEFSPFLAKLTFLPVVRRYKESAQALVDQILLMVKKHNQDYDADNIRDFIDTFLKEQSKFGESEVFNVDNMRQVVGDLFVAGSETTTTTLRWSLLYMMAYPEVQTRVQKELDDVTGRNRFPRMSDRPDLPYTEAVICELQRISTIVPLSVPHVCSEDTTVLGYDIPKGTFLLANLWHSHFDPAVWEEPKSFRPERFLDDDGKVISRDELTPFGIGRRICLGEHLARMELFIFFTLLLHEFTFKNPPDGPPVSLEGTNTSTWAPKNYKVCAIPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B426</accession>
    <name>A0A914B426_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038070251.1">
        <property type="nucleotide sequence ID" value="XM_038214323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B426"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214323.1">
        <property type="protein sequence ID" value="XP_038070251.1"/>
        <property type="gene ID" value="LOC119739389"/>
    </dbReference>
    <dbReference type="GeneID" id="119739389"/>
    <dbReference type="OMA" id="HILMCLA"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="142"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="35542" checksum="D7DD72964EE48442" modified="2023-02-22" version="1">MSLRLEPLHPNNGDAPDNDAANQKLKMLAASNRCCKCCGLTAKLGVQDEWFVRDPCGIVCAVFTYLLIAYGTFAVMTCLLLPRGLDLYTIFHGILFCILSGNSVVSHVRAMMTDPGAIPLGNATREHINNMGLSVGQVVYRCPKCISIKPERAHHCSICRRCIKKMDHHCPWVNNCVGESNQKFFVLFTMYIMLMSLHAIMLILFHCLLCVRSQWGPECLYFSSPATIILIMILTFEALLFSLFTAIMFGTQVYSICTDETGIEQLKQEKPTWVKKTRCMSMKSVFGQKMSLAWLNPFVSPDTKWGKEEVYMYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4W6</accession>
    <name>A0A914B4W6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070984.1">
        <property type="nucleotide sequence ID" value="XM_038215056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4W6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215056.1">
        <property type="protein sequence ID" value="XP_038070984.1"/>
        <property type="gene ID" value="LOC119739919"/>
    </dbReference>
    <dbReference type="GeneID" id="119739919"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="322" mass="36850" checksum="607132EBC812A113" modified="2023-02-22" version="1">MSFAEQIQAMMPDLVNGKTHQQVEEKLAALDRKLGSHVVNGIKFPASVQPSNLEALKTFEVRDDDVYVFTYPRSGTHWLGEIMQYILHDGKGDYDRTFMTNGLEFTITDDPIQLEGVTPGYKTYAAMASPRCIVSHCLESFFPPQIFTKHGKVIYVARNPKDVLVSEYNLLGAEQLDFDEMFFGFVQGKVVLGSWFDHVLSYWNHRDKENFLFIKYEDLHKDLRGSICKLAKHVGKDLPDDVIDDIVERVTFGGMQKTYQQIEEEHGEEGKLMTRFLGVTPYLRKGKVGNWKNTFTVAQSALFDKIYALRMKGTGLDFDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5G9</accession>
    <name>A0A914B5G9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071189.1">
        <property type="nucleotide sequence ID" value="XM_038215261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5G9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215261.1">
        <property type="protein sequence ID" value="XP_038071189.1"/>
        <property type="gene ID" value="LOC119740061"/>
    </dbReference>
    <dbReference type="GeneID" id="119740061"/>
    <dbReference type="CTD" id="374354"/>
    <dbReference type="OMA" id="IAMAGVH"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="719" mass="78515" checksum="5E355FF5919310AC" modified="2023-02-22" version="1">MGSINILDMALRAAKTDEQKREIVLKYLERQCDPEDGKIVQDFPEGLEWFNTKQPLSLHRDLRGKLVVLDFFTYCCINCMHILPDLELLEERFPVSDGLIVVGVHSAKFENEKSSANVLNAVLRYDIAHAVVNDQEAVLWNALDVQCWPTLVLVGPSGEYLLPIIGEGNRKKMLLICEVALEFFKSRGEIAANAELPMLTRLKDTLPESPLLFPGKIEVDGQGNDLAVADSGHHRILVTTREGVVLYCIGGTEKGFVDGSFPEARFHSPQGMVWKDHIIYVADTENHAIRKIDLKAQTVSTIAGTGVMGDHKCQWGGAPGPEQVLSSPWDVCLGGLDDSILFIAMAGSHQIWGLFLKESKWLKNKSEHNAGVCMLYAGSGNEENRNNAYPRKASFAQPSGLVNPHVDYLSCMYVADSESSSIRSVSLKDGAVKGVVGGELDPMNLFAFGDVDGAGRDAKLQHPLGLAWNPLVQHLYVADSYNHKIKVVDPVKKSCVTVAGSGKPGKVDGSILSEVEFNEPGGLCISPTFRKLYVADTNNNAIRVWDLEERKVKELKIIFPSTSEAPVSELDSLSISDQPIKPLVPSSTPATSHPLLDVTPEGAVCIQLTVKLPSDCALTEGAPTAWMAYIKDTAHLVFGKRPISSLDTPLLHRWTAPPSAIEKDATLRIEVAVCFCESASGTCHMTGLAFESPLRMAPSGREGDANLTIKHEMCLEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5H2</accession>
    <name>A0A914B5H2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038071338.1">
        <property type="nucleotide sequence ID" value="XM_038215410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5H2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215410.1">
        <property type="protein sequence ID" value="XP_038071338.1"/>
        <property type="gene ID" value="LOC119740190"/>
    </dbReference>
    <dbReference type="GeneID" id="119740190"/>
    <dbReference type="OMA" id="GEDFWPL"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038161815" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="613" mass="68313" checksum="E5A58460EF1BB757" modified="2023-02-22" version="1">MSRYTFLLFMLGKSLIVLSFLAVVRSQPRVTVEQGVIEGTTETFKEDEFTGAGGTKVDVFKGIPFAEPPLGQLRFKPPMEKAAWGEEVYDATFFRPACLQDPFYAFTLGFETDENCLHLNIFAPNKSVEGGAAVMVWIHGGGFTFGSAIERVYNGLPLAAVGEVIVVTVNYRLGVFGFLSTDDEVSPGNVALLDTVLALEWVQQNIEVFGGNKERVTIFGESAGAVLVGFLVLSEMANGLFSQAIVESGGSISQEVGPLTEEGDKVLRQRAFQLGETVGCSKSDSAALISCLQEVDGNGLIQAQLAVYDRMYPNVDGTFLTMTPLDAYASGTYNHVPMLIGTNADEGTLFFAFNPLFVEYLTDKEPPRVNRTVFDALLVSTFKMFALYDKAVFDATEMRYIDWSQAGYEDADYFRSMVEFSGDWLFTCNVDKLARLHARENRVYRYLMTHVPTVSYYSFQGVTPGWIGAGHAEELTFVFGAAFVPGNPSANLTDAEKVFSVKFMKLWTNFAKTGNTSEESAGSPPISDEYIWPLFSSPDLEYKVLDLNLTTSRALKSDQCYFWNNYVEQLRTLLGDLDEVERDWRQSFETWKNTDIADWREEFNKYKATTDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7L7</accession>
    <name>A0A914B7L7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072168.1">
        <property type="nucleotide sequence ID" value="XM_038216240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7L7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216240.1">
        <property type="protein sequence ID" value="XP_038072168.1"/>
        <property type="gene ID" value="LOC119740806"/>
    </dbReference>
    <dbReference type="GeneID" id="119740806"/>
    <dbReference type="CTD" id="5891"/>
    <dbReference type="OMA" id="FHFPFKK"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07831">
        <property type="entry name" value="STKc_MOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000271">
        <property type="entry name" value="MAPK/MAK/MRK overlapping kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000773">
        <property type="entry name" value="MOK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="454" mass="52479" checksum="25979C18DDAC15DD" modified="2023-02-22" version="1">MHKYRVLGKKGEGTFSEVLKCQHIKDGTYYACKKMKQTYDSLEQVNNLREIQAMRRLSPHENILELIEVIFDKKTGTLALLCELMDMNIYELIRGRRHYLAETKVKSYMYQLLKSLDHMHRNGIFHRDVKPENILVKLAREKDDLLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYKMDLWSVGCVFFEVLSLHPLFPGANEVDQIAKIHDIMGTPDASILNKLRNKTRGMNFNFPPKKGTGIQKLLPHASQESIELIFQLCTYDPDERISAKQALKHPYFKDVRDADKRKHQHAAVKKAEEESGKMSPNSVDEVNAKTNNNNNIISTKEVDVTYQPQQRRRRKPRRFQEPDKTYHTTSLLPKVAQSSQITASNVSSFPTMSSFPSSTFPKLHTGPSMLPSIANSHYNKHHQHSKKTTTFQQPTKTIYGHYQLPSIHKGKGTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7R9</accession>
    <name>A0A914B7R9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071855.1">
        <property type="nucleotide sequence ID" value="XM_038215927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215927.1">
        <property type="protein sequence ID" value="XP_038071855.1"/>
        <property type="gene ID" value="LOC119740577"/>
    </dbReference>
    <dbReference type="GeneID" id="119740577"/>
    <dbReference type="OMA" id="CENINCW"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1891" mass="216134" checksum="A9014DB1ECC77EB1" modified="2023-02-22" version="1">MSNRTSSSVHVKAAAKRAELLCRQRLLTKKQELESRHLAVQQARQQEEFRLQRERENFDLQVEIEVSEASISAIEQYEDEFDQKIRFKLPDEIPHPAACASSVLGDRIEAGASEKVSSNEEPNKIENPWSIPQDFQVKVDEVENRMPELTPQVNIGQLHKDCAQLDHHVPEPTTAQRYQPHLQPISDIGELTQLLIKQQVRAALPAQQIETFNGDTLKYTRFVKSFEFGVEDKTTDGRDRLNYLCQYTSGEPNTLVSSCLHYHDAEEGYSKAKELLAKRYGNSHKIAQAVLNKANNWPDIRAEDATGLNKFSIFLSECKNMTSSVSALSELNHTQSIQMLVEKLPYRLRSMWRNKVYEVEEEKKRCIVLDDLVSFVDRHSQILSNPTFGRLRETPHLGKNNIGEKNKRVQVKKEAFGTAVNSHAEKARQKKSCQFCGGNSHHATLECMKFAQLSWKDKSSFCFKHGLCFGCLGVGHTKSSCKQRELSKCSKCPGNHPTVLHNDEKITKTSHPAQNSQTQVTTGCAGVLGAGANLHASGSPRMAIVPVLVKASSSHECIATYAFLDNGCGAVFADSEICRALKVRTRKRSIILKTLNSEEVVDSAIVIDRLQLGGMIEENSFIDLPDVYVKNDIPVSPEDMVTKDDLQEWTHLSHIQLPQLCSPAIPRVTLIIGMNVPAATTPIEVIRGDSGDPYGVKTPVGWVIYGVPGRPKSQLDANYINVLDGLTNLENQYKHYMNLDFNERLGESQDESALSREDMRFLDIVKETTEFQGGHYQMALPLQRPTVRMPDNRSLAEKRAVQLKRKFDKNQEFKEKYVQAMEDTIGKGYVEKVPDSQKFRSDGKVWFIPHHGVYQVQKQKMRVVYDCAAEYGGVSLNRQLLQGPDMTNGLTGVLMRFRQEPVAVKADIEAMFYQVRVRSEDRDLLRFLWWPGGDLSRELEEYRMTVHVFGAASSPSCANYALRRTATDNEQRYRSEVTNAVRKNFYVDDFCKSVPDKEEAKVISREVTDLLAEGGFRLTKWVSNQREVLRSIPREEWSKEVKGLQIDQDVLPPEKTLGVLWCMESDTFGFEINVKVREPTRRGILSIVSSVYDPLGMVSAAIMPAKLLLQDLCRLKLNWDEKIPQEHLHKWNLWLMDLPKLECISVDRCFKPEGFQDPVSVQIHHFADASEKGYGVVSYLRLQNRYGDVHCSFVTSKSRVTPLKQQSIPRLELTAATVAVRVHNSIVRELEIPVDQTFFWTDSMTVIKYICNETTRFKSFVANRLTVIRDSSHPCQWKYVRSEQNPADDCSRGLSIDKFIANRRWFRGPEFLWHAEADWPSTCVTEEPEVDRDPEVKRVMAAVPIENLLSRSNAVKKLIEYYSDWNRLRRAAAWWLRLKRILRKRSKEEFKHDAVNNLTVEEIEEAEVSILRWVQHEAFPHQIKRLQEMNDGPQDLTRESPKQQKVDKLLDQLDPVMHKSLMRVGGRLQAAQLPEEAKHQIILPQRCHVTDLIMQHTHQKIHHQGRNHVLAELRRRYWILKAGVVLKSVLKRCVICKKVQAKLGQQKMANLPANRLLSEKPAFTSTGIDYFGPFNIKQGRNIKKRYGVVFTCSTSRAVHIEIAESLDTSSCINAVRRFIARRGNIKELISDNGTNLVGAHAELKKAMSEWNHETLEKFTTDRGITWKFNPPAASHFGGIWERQIRTIRKILQAMLNEQHMRVCRDEEQLRTLMCEVEYTINSRPLTHASDDPKDLNAITPNDLLLLRPSSLYVAPPGVFSEKDQYAKRRWRQMQYLADLFWKRWSREYLMDLQRRQKWLYPQRNLHPGDVVLVADNQAPRSSWPLGIVEKTYPDKNGLIRSAELLLKDTNQTVDLHKGDLQCSTATISPGTPVSSMQCDLVIADGAAGMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BAW2</accession>
    <name>A0A914BAW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073204.1">
        <property type="nucleotide sequence ID" value="XM_038217276.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073205.1">
        <property type="nucleotide sequence ID" value="XM_038217277.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073206.1">
        <property type="nucleotide sequence ID" value="XM_038217278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BAW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217276.1">
        <property type="protein sequence ID" value="XP_038073204.1"/>
        <property type="gene ID" value="LOC119741500"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217277.1">
        <property type="protein sequence ID" value="XP_038073205.1"/>
        <property type="gene ID" value="LOC119741500"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217278.1">
        <property type="protein sequence ID" value="XP_038073206.1"/>
        <property type="gene ID" value="LOC119741500"/>
    </dbReference>
    <dbReference type="GeneID" id="119741500"/>
    <dbReference type="CTD" id="54883"/>
    <dbReference type="OMA" id="SWHPHTM"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="585" mass="68645" checksum="9F3657B89C2560B4" modified="2023-02-22" version="1">MGGGDLNLKKSWDPRRHDNQEKKWKLEELDKKERQRMKEMLEERQGERSMEDMRRKGEEAGVIQKRKDRVDWMYKGPDSHTNPDDYLLGKEVDKAILEAQHGKKTTGTQGGIASAGAVVGSSASTSIDAKDMARKMREDPLFAIKKRELNNRKELVSNPIRMKQLQQMLQTQVGKDKKKSKKSKKHKDKKSTKHKKSHAASSDSSSEEDHSPSPAKRRNLHQHTSPERYRVKGHHRDEDRRRESPIRSGRDEKRKMPSLDPAKMKKLLEREMLKKHKKHVDVSESSSSESDSDDRNATKQKRQIKSEHLSRGQHAEEDRKQRYRPHENVSDSRKGRKDRSVSPEVLKRKHGVGSEKSSAKYGLQRGARSSRRSQSQSPERVPRDQFRHHHSESKDRHAGKHHDRSPYRDSDKSRDKHAEKTRDLRRDNRSPSPEPKRDKHSDRYGDSRAEKHGRRERSRSRTPVKERGEFRDRSRRSRSRSPQRQNGSRGNVVSKRKLTAEEMERKRAEMMDNAKWRDDQRRERVKVYEKEEHAELEMEKKKAKTAEFVQPLKLPDNSSVEDRIHRNIYSIQRTKAALDKNFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBA0</accession>
    <name>A0A914BBA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA box-binding protein-associated factor RNA polymerase I subunit C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073492.1">
        <property type="nucleotide sequence ID" value="XM_038217564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073493.1">
        <property type="nucleotide sequence ID" value="XM_038217565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073494.1">
        <property type="nucleotide sequence ID" value="XM_038217566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217564.1">
        <property type="protein sequence ID" value="XP_038073492.1"/>
        <property type="gene ID" value="LOC119741704"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217565.1">
        <property type="protein sequence ID" value="XP_038073493.1"/>
        <property type="gene ID" value="LOC119741704"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217566.1">
        <property type="protein sequence ID" value="XP_038073494.1"/>
        <property type="gene ID" value="LOC119741704"/>
    </dbReference>
    <dbReference type="GeneID" id="119741704"/>
    <dbReference type="OMA" id="SSREVHC"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038801">
        <property type="entry name" value="TAF1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049087">
        <property type="entry name" value="TAF1C_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049090">
        <property type="entry name" value="TAF1C_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20641">
        <property type="entry name" value="TAF1C_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20642">
        <property type="entry name" value="TAF1C_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF1C beta-propeller" evidence="2">
        <location>
            <begin position="282"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="TAF1C helical bundle" evidence="3">
        <location>
            <begin position="537"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="95523" checksum="771F19C1C0E4ED8E" modified="2023-02-22" version="1">MSSSAYAFPDTHFPSQTLPNRQTQLPDGYGCYHAADLDTDNRQGMQGELRFRFQYRHGNEGMTLVANEPTLPLLQPQECCQIPLPGMQDLTRVSTIYNTRQIQDRAVDQAYYFYENFPDLVWGSALDFLKDSYIDYEPRKRRKSKKRRVDDATRNLFEVRTEDKLSQLHEMLEPVLYDINPNMLLRLLKEDVNENIHKLYVDQDFYGGCLAYQSLPASSVHEGLIFYPTGPTLEVLNIRTVPHQGVPIYSMKSSPCRQFKLVSPLRQIETVSVPYRGAVVAGLRSDYYFCLMKVTTTKNKIKARVSNFIHSQQKIASVAVSPFIHGECLLGLDTGAIQLVSPEKGLTCVRAMPALEEQSTCRCHYGGHPRCIVVQQKKHIDLVDFRAPEDSGSSCLLSIPSENLPEHQEVFVAKQHPSNHFYHLVATQDLLLLLDERYPKYNVLQWCHMLNAPPNFMDIIPQAVTSDDLTSDPTSNDLTSDLIVLASQCSREVHCFQCSELNGCTPVSTSQPWKIASTDGWFDMLPEYPPVDLDPVRSRLERPLIGVSGAKRTSCAGCEPGVTVFQLSTAGDLFFQTYSQKSCTDDRQDKTLSRGPGCPNVQLGQESLTNCKAWIEGVLRQSVQEPEPLGFKTVDREIARNVFKSMTFPEAIPSKDCTLCKTPESWPLDDQSTDRSQPTDRSLPCPACGVEIVDSAEFQDCLEAGEKIIFRRRGIDEEGEEAVLPGKIDPKMYPDEMSKTLHRLWLRGYDGDDDDDDDSDKDVNQEADVVPKHPHRTHQPSKTSQVSAPKRQKSADATSQDAPDGRTAASQSLDTTDQQRAADLQRIRSARLSKLNWKVKFKRGAMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCR4</accession>
    <name>A0A914BCR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074023.1">
        <property type="nucleotide sequence ID" value="XM_038218095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218095.1">
        <property type="protein sequence ID" value="XP_038074023.1"/>
        <property type="gene ID" value="LOC119742072"/>
    </dbReference>
    <dbReference type="GeneID" id="119742072"/>
    <dbReference type="OMA" id="DIACERM"/>
    <dbReference type="OrthoDB" id="538816at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036742609" description="C-type lectin domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="20038" checksum="1C75D765432F1C85" modified="2023-02-22" version="1">MFWWKVGNLVSLTIVLSDSLSSSTPCSRRHGLCTAPWKKWGGSCYLSTQKPLTYDDARGACRRLGAKMAAPRSDQENDFLASLAQGSDIWVACTDRRQEGEWECEGSQDGQGIYTNWKMGEPNNAGSEGSEDCIKIRRVDKKWNDIACERMFLAVCKRQFVGSCFTTNNEGRLEVDSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHB1</accession>
    <name>A0A914BHB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038075280.1">
        <property type="nucleotide sequence ID" value="XM_038219352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219352.1">
        <property type="protein sequence ID" value="XP_038075280.1"/>
        <property type="gene ID" value="LOC119743035"/>
    </dbReference>
    <dbReference type="GeneID" id="119743035"/>
    <dbReference type="CTD" id="5663"/>
    <dbReference type="OMA" id="MYYQDID"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="484" mass="53638" checksum="1AC244ED01837ADA" modified="2023-02-22" version="1">MANLCADNDSLSERTSLMDSHAEARNPTQSLAAGRPSTGDGEATEVRRSRNAGSGDQNSERSRGQRQRNASEEAEDEEEMLKYGAKHVIMLFVPVSLCMIVVVTTISTVTFYTAPGGGYLVYTPFHEDQGGAGTKAWNAVVNALIIIAIVLALTVVLVMLYKYRCYKVIHGWLILSSLLLLFFFAFLYLQELMLTYNVPLDYFTACLVMWNFGVVGMICIHWKGPLRLQQIYLIVISALLALTFIKYLPEWTLWTILAAIAIYDLFAVLAPKGPLRVLVETAQERNEPIFPALIYSSTMAWMVGMANNDPNKPRSDGCENPGLEESTESGAGNTEPDEEETAGGFDVEFRQRQDRDLQRDLSNSEEARAAVNALRQAPERSQRRQQTEDDEDDEERGVKLGLGDFIFYSVLVGKASAQGDWTTTVACFVAILIGLCLTLILLAIFKKALPALPISICFGLVFYFCTSLLVFPFTDSLASSQVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHG1</accession>
    <name>A0A914BHG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074872.1">
        <property type="nucleotide sequence ID" value="XM_038218944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218944.1">
        <property type="protein sequence ID" value="XP_038074872.1"/>
        <property type="gene ID" value="LOC119742775"/>
    </dbReference>
    <dbReference type="GeneID" id="119742775"/>
    <dbReference type="OrthoDB" id="10148204at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="327" mass="35469" checksum="9A2F75D91EC2F34B" modified="2023-02-22" version="1">MDTSSSTDSQPSEFSDYNQRVVVAIMIGTASLVGIIGNSLVIGAVLLSKVLQTTTTAFIFSMSVAHLLCSLVLPWDVVVLLSTGDLPRGDREWICSVTTVTISITIGVGLYTLAAIGLNHMLLITRPTAKFFTPKKIAAAMVVTWLIPCLVVVVPPLIKVGQVGFNEKFHLCGSKFTPGCKTYNSIRVLGLYPIPLVCIIVCCVLIWSHLRRHAHVPATSSDIVGPTQMITKTMPFLLGATIIFMTPYALCRANRSFEPALAYASAILFSSCSINPIIYGIRHRDFKTVFGCILRRGWNDIPQPSALLQSMGGVKSQDKEEVGLHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHH3</accession>
    <name>A0A914BHH3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075544.1">
        <property type="nucleotide sequence ID" value="XM_038219616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219616.1">
        <property type="protein sequence ID" value="XP_038075544.1"/>
        <property type="gene ID" value="LOC119743226"/>
    </dbReference>
    <dbReference type="GeneID" id="119743226"/>
    <dbReference type="OMA" id="HWALNID"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="56846" checksum="5A2CC26932497EB4" modified="2023-02-22" version="1">MRIGMAASLLDVLDSRTVLICLVVFLLVSWIVRRRRSSVSGTLPPGPWGWPLIGNLPSLAFASNAEEPYEVFMRMAKQYGPVFSLNILGQRMVVVHGYKAIREAFNNPILSDRPELHILRNLFNGAEGVATASGDTWREQRKLILNVFRNFGVGQARFEDQIATEAGHLVSEMKGLQGQAFNPVHLFGNAVSNVISSVVLGRRYDYDDPAFQRVLASMDRSMELIGAGAAMQLLPFVNRLGFLPNIKEMTATMKFVMDFVMDIVKKHQSDCYSEEPRDLMDVYLREMRSKEERNIPTHLSVMNLVLVVSDLFVAGTETTANTLRWGLLFMMLHPEIQSRVQQELDTVVGRERLPQLADRRNLPYTEAVILELERRGNVVPLGLPHKAAADTTLAGYTVPKGSLVVANHWALNIDSEVFPDPLVFNPERFLNDDGEVTKPEELIPFSTGRRICLGEQLAKMELFIFFTYLLHQFTFKKPEGSPPLSLKGYLGITLAPTPFQVCALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIL0</accession>
    <name>A0A914BIL0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075681.1">
        <property type="nucleotide sequence ID" value="XM_038219753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIL0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219753.1">
        <property type="protein sequence ID" value="XP_038075681.1"/>
        <property type="gene ID" value="LOC119743360"/>
    </dbReference>
    <dbReference type="GeneID" id="119743360"/>
    <dbReference type="OrthoDB" id="9882192at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="129" mass="14391" checksum="B4ECA22417DC2E07" modified="2023-02-22" version="1">MKGTIERLRTKVEYLSNTNMSLKQQLSMIHTSSLKHLTNDSENQSILQELLQHMSEEHTQLLHHHLAQLRLYAQACALSKSAPEESAAESTVLVPDLADQSQDISHMAMMSSSEGTLGNMEQTVVMTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIR3</accession>
    <name>A0A914BIR3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075994.1">
        <property type="nucleotide sequence ID" value="XM_038220066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220066.1">
        <property type="protein sequence ID" value="XP_038075994.1"/>
        <property type="gene ID" value="LOC119743926"/>
    </dbReference>
    <dbReference type="GeneID" id="119743926"/>
    <dbReference type="OMA" id="CYLPKER"/>
    <dbReference type="OrthoDB" id="10052339at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="288" mass="32321" checksum="880C462336D455A6" modified="2023-02-22" version="1">MHALLRKVTNRGQIRQNDGNALWDLARDMKKCQITLSQLGYNADMNSSENLLKVQRLLPVHLQADWAKKAQVTIESKREPSFAQMTEFIETKAKTASNMYGQNITKTFSPTSASHSSRTKPKAYPAKVTALSTSVGGDYLHEAKKDKQVKCLCCSQQHKLAECKTFTQKSYDERRQFMRDNKLCDNCFIPWHVARRCRLSSRCGIDGCTWKHHTLLHPSRAPVANREEQKGCKNPASVKPEPAGTCTSTGAGRRVMEGEKDQPGECHAVTSRQVALRVLPVRVKHNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIV6</accession>
    <name>A0A914BIV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075835.1">
        <property type="nucleotide sequence ID" value="XM_038219907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219907.1">
        <property type="protein sequence ID" value="XP_038075835.1"/>
        <property type="gene ID" value="LOC119743485"/>
    </dbReference>
    <dbReference type="GeneID" id="119743485"/>
    <dbReference type="OMA" id="KVWALHC"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="143340" checksum="71042CCE33E95411" modified="2023-02-22" version="1">MGFLQGSSPRRHYEGSMLEILHVHILVPQRCAPNRGRTRTDSPVSGYVLIKKEHDKRGNLLRHNRSTSLVIEKYIGELESSKLNTREFEEEEQLGSGTESDAQDMMQTTGSTFSKMQSKLQALEDRKITCIKILQEMDTYYDEAFSRVKQSTRISIKRSLAELESGGNVRFEEGHSSSAWFASCHDLILSRFCAADYKAYNILGIQIHGITRVHNRMLRYRFDNKLCAIIEEDEPLAVTRTPTLKRLQEYLFFVWDPDLPGGENEPVKILEEGPMDCDTYSQLGLHGAVHLSNSVSLCDKARIESAIGKAKKETCTDPCPFRFGQLVVCKVYLGKSLPALDVNVKISKQLYPIADSVFKPKNFSLEENEHQCECSARQCEWFIFDHELVLPEYVIDFEYKTKEVPPSPFIDVSDNQAVERKPIEQSFDLDVLRLDPVVKPRPRLVSLSEDVILQISGVTSLTLVSVLNLHGNGLTKLRCISSLTSLQKLIISFNELSKLEDLAYLPHLEFIDASFNKLYTLDGFRGMSKLKYLDISWNELTNMKDDLSILRKHATGLTCLDLRHNNWQKPDGVRLRTIGRLKSLSLLDGQAVTESEATAALRMAAGSRVSQVSLLAHTRTDSCRPRSLSLASCAQLLTQISRQKPDRLCETDGNWYSKVTTLNLDGQHISKLSNLERLVNLRWASFNNNDLTKIEGLDECTQLEELALEDNCIYKLEGIGKLTKLHTLNLSSNNISTLEAAGLERLTQLQCLAVCNNRISSLAGLAKTLSLLELYIGNNRIQNIREIFNLKHLPNFVILDLFGNPVASVENYRLFVVYHLKNLKALDGSAVESSEGGTAKDKFGGRLTQDFVAEKLGHSNFHEVRELDFPQSALRQVDLGTGEHFINLRSVNLEHNSLQSFCGLVYLVNLRVLCLNHNHIECILPRPKACGSKGYLKGYREDLTDIYSPGNFTPILENLEVLHLGYNGITDLIRLQISRLPSLKALFLQGNEISKVEGLDSLQDLREIVLDRNRIKGLSEYSFMNQWNLVELHMEENRLRDLSHLQYLENLQRLYLGSNRLQDVCELEKLEALPNLIELSVISNPVSRRLMHRPLLVLRQPNLLCIDGIPVSPEERTKAEMYFLEQQPATSGTSTQETSLPGISPYKNQAAPVKITNVQLQGASMDRSNWGQSAQYSTLEDQVGYQQDNFRAPNRRQRSVHSDTTVSANINGNRAAQSSHAQGHSRTQYQLQHQVPYVPHQGHYQGATTYEDGLQSKYCQNNGGKGLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJA7</accession>
    <name>A0A914BJA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038075527.1">
        <property type="nucleotide sequence ID" value="XM_038219599.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219599.1">
        <property type="protein sequence ID" value="XP_038075527.1"/>
        <property type="gene ID" value="LOC119743212"/>
    </dbReference>
    <dbReference type="GeneID" id="119743212"/>
    <dbReference type="CTD" id="9736"/>
    <dbReference type="OMA" id="KLMYSLY"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000014">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="2083"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1383"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3524"/>
            <end position="3590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3617"/>
            <end position="3688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="3558"/>
            <end position="3569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3632"/>
            <end position="3643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3664"/>
            <end position="3674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3678"/>
            <end position="3688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3710" mass="423040" checksum="96D363A3DE371371" modified="2023-02-22" version="1">MEGCDTCREVFRLVSSYIETCGAGEKFDVRKKDVWILLEFSQIWGQRQCSCLFKDYKNFERLNNLVQLILRFAINIIANPTHPLGDVGDSEIPDKEVSVQESEEKPKEAKLTEEVTRQKAEVESRNPSPEHQKVTQDHSVVSTDANSSTNNESASRINKQDQIFDDEANPTKKEEEEEKGNVENKETCAEVWNLEEEEKLLQFVAKVFQMNFPMYAAHKQYYHSLAEQETSCQEAEALGNYCDMNDLDVPIHLLRNVCFFCDSNGLAVIRQCFEAATPDSLPFSLAHAIIAIVANLRLWLHLHAVMQFVAPLRTHVIRYLCRLPDKELRRASARSMADMMWSAIKEPMEAPLSFDRDSLELALKYFMSSTLTMRLAGLSQITSQIHMFNEVCNNESVADIDNVGSQLTAWLLEKEVVEHLFGPNMHLEIIKQCQIILNFLAAEGALTTKHIDVIWAATQLKHTGRYVHDLFPHLIKHLEAGPLFHLLKLVSRLHPSEHTEQTLYLSQVITKCIWTSALSSSAVGATTLLRPDVRHSQHEFPLLRSSLEMGPDKGQLGVMNSNNSRMVEIYELEEENDDAEETTPSVTEDQPSNCSRNQEGDANKVEPHRTTKKESDTHEGKPRQEISDEPTSGTHSQKTIHAVAIHRRKRLLKPRLAEDGSESSVTEHDSDNIDSENEAMVTSPENSDSDSDVTEESEEHGTQLGSEYEDVSEESNAEMQSEEDEDEEKSGIRHSCCSDRHRSTLLEHQSQLRQCLQGGDISDSASSEESEGIQHRHFFQATVRPQQRIKKQLLVGNLEEKVQDDGQEEVQGQKETEDAKELGRTQTHHEGVIPPSPKSDHRQLPQEAREAEDYYVRNRGLETEVYDCRRYLPHRHTVQSNIMDELISAEEEGSCSSSQASAKSDKNMADFDGEEEEEDSACEDELVQLSAHLSSIHHHQHTHRHRHHQLPDISPVYRSRLSSTCSHHAEKEDLATPFVDFNFDDVCKKGHTLLWDQVQDENAIHLSEGLAAETEKLLCSLVCWFPEREIRMKFVEGCLENLKNNRSEVVSLRLLPKLFGSFQQYRNNYNTHWITMWAEEELHMMDLFFNNLVHYTSQVRSCVQQERTLYTHTAEVQARLQFLTCVFTTLGSPDHFRLTLDQVDTLWTCLATDTECGDEALSWFLNQAGNKDQHALGLETFKHIFFNKMPQLEPESISMTGLNLFQQLCSLARLASSSSYDSPPVEMPGIDHLWKIALRAKNTDVSLSAIKYINTYYINAGNGSLEKEEEFIKRCMESLSQASAKLDSAQDSSLLVLQRGLTLLKTHLEAFRKRYAYHLRQWQLQGRGISSHKRHPLEGHSQTLRVVCQLANRTEKFTVELSSSDLVADLRAEVTHISEQFQQQQLQQQQQQQEESDNTATTAGFSGLAGALSGSTIQAQRPVRMISVGHELTPDLDEKSLKEMAFSDLQLVFVSFGAIRRERKRDGMDQPASCLPPPPQAKLPMMLLLQEPHFSCLFHLLQQLNELLVDNYAGEAAQDLLGRTQMLSRNVWHLLMLLPTSPDMLNKFKVLTAPMDSAMSSEDDHTDIETDKISTAEDEPGSIQTAFTANWPELLDVSNTHKLLYSLQIVESLGQPAKKKRGKSLACVNRGDHSPMTSSSELGTMDLKGIKPSQSESGLSTVGLDDGKESWNTMFVESGGLRHLFNIFMSGNLEARSGQHWNLWQQDCLACILKLINEFAIEQAALDQGQDDVFEAHSSSEEVTSKCPRRTKHNSTEVGGITTKVSKQLLELMSGEGVLDRLITVLYEAAVPSDTVKVRAGYWVIHCALKLLVSWAYSDPEVRVALCQNKLFDKWLQRLVLQTSEVYVRREVCDALYRLCEGSSRPCQHFSWALLASLLSFLSLAQSIHPKKDYSKNIEDYGPGCRNYFWLLCSIMDNIDRKHEWSSGSDVDNSPALDQEKKVINVNTIARHLAEGIQSRLVLEERHNTIEDVALTGMLKLCTAVMKHNPPFKFSKEGQVFLSSVFECLFAVPNMEERNLPKCKSKGSRLAGFDLLIELARGCQDNYSCLHRLMLEQHSPGTHGAYPWLYWPQDDGRSSCGYVGLTNLGATCYMASCMQQLFMMPEARAPILSARLTEDTHHASILTELQRMFAFLQDSERKAYNPRSFCKVYTMDKQPLNTGEQKDMTEFFTDLISKMEEMTPQLNDLVCDLFKGELTNNVVSLDCPHVSSTTEEFCTVRCQVADMKNLYESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKTLPKILSFNTMRYTFNMVTMMKEKVNTHFSFPLKLDMAGYTEAALMGTDRNRPDNPTEDASYTYDLIGVTVHTGTADGGHYYSFIKDRMLSSDDRWYMFNDAEVKPFDSTQLAGECFGGEMTTKTYDSVTDKYMDFSFEKTHSAYMLFYERCTPGVDQQEPASQPTIMLPKEIAEWIWQDNKNYLRDRSIFDHSYMNFMWQVCSYLPSTLPDPSHVQLMASKLTTTFVLETLLHAREKPTMLQWMELMTKQFHTCQAACEWFLDYMANDDWWPQQILIKCPIQTCRQLFQRLCIHVIRQLRDKHAPLYLHPIVDGEDEVDIPPEEIGNYSCVTRFIKKLLSIIEHGVRPQCKHLTEYFSVLYDFAKIDEDEAQFLTSVEAISIMTNFYLGTKAADYVEVVSDDDNEDDEDEDDIISLTEEKYKPTSLEKMISLIAYLVDSSRTDRQLMLSQTDYAVLVAGKGFPFLFQQIRDCINLQQTRNLIISLTRFQPRLAEQIVAMIFNAIAKLNQEAGQPFFKILSMLVETVGGLPGVPPFTPIILQRIWEVSEFNPIQVLDWLAAQTPRNKMAHHWVLQGIKTWVEHFLLAHNNVRVRNAAAFLLISLVPDPHFRQSFRSARSVHSPQKEIQLSPEAVIILQQIYSILLRLLPRARHYVDASIHGTTKLVAYFSVLSHCIISKIEKRMFSQFFMDLWNLYQPKLSEPPLACNHNKQALLQFWYNACVDVPENVELIISNPTVVKHIPYNYILADHDDQEVVMFNRIMLPAYYGLLRLCCQQSPQFSRALAVHQNMQWAFRFLTPYASQYPMVVDELFRMMKLFVSRQPDMRTEESAQIQEFKRMTLRCYLECLERSSCWTTLISAFRVLLENDEDRLGVITYHGLSRLADAFNTLHMMYHEATACHVTGDLVELLSITLLTLECASKYRERKEVKQSLLQWQERMEFAQKLLTLLNCYTPDNVRKESLALLNELVILYPRECVQRLVPIILHVHHQFQKNNIPLATGPYFPRRMPKPAPNKASIRPPRPELQMFLHPSQLETSHGSDPVYDAALREFFLPYHQFVETLCYTALNINLFTEDTINLSVLVALEGVPLQLDWFAKLWRIMYQSEGSDRAGVQMLCSHHTFHDYVEGIILDERTSFNNPAINSFFCIFFPKVYKHILCNNWESVVDSFICGILGDTDNLEHFRQDELKRTAYKVNGDIRTLLLMFSVVPPRAINPNFLPALHHILTTCKNDREARMTVVLRGQSAEVADKEIDKRRCVDQSEQDTEAVPKKKRRSSPDIKESTEGNSSPPPPPPPPPPTTTKDQQTVEPKAQFPKITQNKQEVITMDSIYHADVPADIVRDATLENTLPSSDTEEDKCGGDSSESGSKTTEMAESSILPKANPPTCQPLHDDVSPSSTVSSLSRTLKRGSSLSSSARQQHCVDVLARSIEQLIKCLEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJC2</accession>
    <name>A0A914BJC2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076378.1">
        <property type="nucleotide sequence ID" value="XM_038220450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJC2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220450.1">
        <property type="protein sequence ID" value="XP_038076378.1"/>
        <property type="gene ID" value="LOC119744506"/>
    </dbReference>
    <dbReference type="GeneID" id="119744506"/>
    <dbReference type="OMA" id="VIQECIM"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="112" mass="13049" checksum="6CC83451C64B4FA8" modified="2023-02-22" version="1">MAAAAQDPRIRNIKIKTGVLKRLVKEKTMYEKEVTDQTAKVERMKAEEQDEHNIRKQQEVLEESKMMIPDSNRRIKTAFAELKNLLETTEELKEDENYQTASTLIEEVSPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJH0</accession>
    <name>A0A914BJH0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Homeotic protein spalt-major</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075971.1">
        <property type="nucleotide sequence ID" value="XM_038220043.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220043.1">
        <property type="protein sequence ID" value="XP_038075971.1"/>
        <property type="gene ID" value="LOC119743627"/>
    </dbReference>
    <dbReference type="GeneID" id="119743627"/>
    <dbReference type="OMA" id="LPCANAR"/>
    <dbReference type="OrthoDB" id="8749569at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035107">
        <property type="term" value="P:appendage morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002381">
        <property type="entry name" value="Putative spalt protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000341">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000291">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1193"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1468"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1496"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="504"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="870"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="935"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1024"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1296"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1024"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1335"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1367"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1396"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1448"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1628" mass="182208" checksum="97D409259BC2D555" modified="2023-02-22" version="1">MAKEEYLSEIVTYDLFTSFHSDAGAAKESHLNAANTEETDEDVIIGGVHVCGKCRGEFTVSSDFLQHKQTCSKKPVVVVINNDGQPQAESTNSSRPPSAQNQYGQEITKTVYHNNNDQALNGLQQLQDSQYDDQEEIEEPSVTEESEAHLTQEDGPQDHQQHQPSLDNGMHEEDIKASNSDRLRTQSVDSMEYEESHSLLKQHCENSRSPSSRPVFPGSLENAPFPMGPFPRPPHNRPEMASIQDQLFHLQQQHIHQLQLIQSIQQQLQNLAMQIKNTPATTSANTPVTTTSAPLTPSVESQPQLMSQPTSSSGPSPQLMHPFDSLPRPLPQQMMPSLPLRPSIIPPVSFPMPSPRPPFNMLHQQGVMPPVSSQLLQAPPRLPFPPAMMLQRKGKPPNVAVFDPKFPSDDPFFRHKCRFCHKVFGSDSALQIHIRSHTGERPFKCNICGNRFSTKGNLKVHFQRHVDRYPHVKMDTTPHPPSPPLPNERLPIQSPSIQQVPLPTIPGEMGRLPNDVPTSFHPGIPMSQASGSDSASSSISGDQPLEQQSQEEMCPKSVPDIVLPKSESESKTSDADAVVSPQLSQERSPAFSSAPMTSSFAHSISQIMSESSCTFTTAPIATSKTETPSSLAALAEQGFRPSETSKLQMLVENIEQKISDSSQCVICHRVLSCKSALQMHYRIHTGERPYKCRVCLRSFTTKGNLKTHYSVHRAQPPLRMFHDCPICQKRFSNVLVLQQHLRMHAAEGFQIPQDLSAFEHYAEDKFVEELVCDENQGLDQDDDDEDARLNEMASQMESSPEGFSEPEGAEGELPNGLPVDSGNLKQIKSASEQDKGLTQKIHRDLMDRARGIERVMDVSKEMRMDWMGKEVEESSGVPPTGESTSPPAYLTDDSSLAASPSSEPQPNYTKGIDSIASALHLQASNNAENHHRQLISRLPNPDPQSPSEKSQEGSLVSDQASQSPDDHNDDQRLSQEDVRRHEDEINRHGSIQRSHSSEPRGHSDDLNLQPNYIKNHHDELRRHRDEMGSQHGDSRRHPGSTYQNELQGKQDDKSHAGDSEQISDNECISRNVEPRGATDEHRGEHRHIFDEHKSHPDNLKFHQDDLHRAPLKIDTSRMDNNGALDLTPKSVSSGSSENSLEALKNQVNNSHYLFPMGFPHPGDGRLNGSSAGLLMPDPSNTSYGSRRSNGSSTTCHYCGKSFACSSALNIHYRSHTKERPYKCEICSKGFSTRGNLRQHMLTHKIRDMPTQILDPSHPHYKHQQQQQMMHPMHHLQSPPHSMLMPGMPNFAAEMAMHQYHQQQQQQQQRTSPRPFIQRDPPPSHPERQRSPQTHQQQLPSPLGSPQKISPLNPQRPASPFDDTQEIPLSSQMKSPSSQQSTPPSSQNHLTPSSQLQQQQQQQQQHQQQHQQHHSPNNNNKYQPDIHQKLYPSLQKPHPTDLPIPPSQPSLKRSISESSCPSPPKRLRHSCHVCGKQFQSDSALQIHIRTHTGEKPFKCHICGRAFTTKGNLKVHLGTHMWNGGPTRRGRRISMEAPLMRSPKEGEMFRPDMFGLRPMYEGAFFQYPPPIMNGFAAAMSKANEISVIQNHHSSIGHTRIPEGSNSVIMKSRELGHDSRDQIPESVASQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKQ1</accession>
    <name>A0A914BKQ1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076366.1">
        <property type="nucleotide sequence ID" value="XM_038220438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKQ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220438.1">
        <property type="protein sequence ID" value="XP_038076366.1"/>
        <property type="gene ID" value="LOC119744497"/>
    </dbReference>
    <dbReference type="GeneID" id="119744497"/>
    <dbReference type="OMA" id="PCLNPMY"/>
    <dbReference type="OrthoDB" id="5987175at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="520" mass="57833" checksum="B76B25378DA6B291" modified="2023-02-22" version="1">MDSLEIDVHADFDSEFQQSGRVATNEHDSLEAKLQANSDDIKKLSSSFAGVQNMLLTLLNKDQEKEEAKTEVTCNSIFEDQGCFDPCLDFELISNVTANSPKVDNQGDFDILPCGDLYESTEAKGPEIFANLADRAIKAVTLPIKKKNYNKIAEKYTTLANSPAVTAPRVDADLWSTIPATARTKDVATQLIQKHVVKGMIPCFHIINELREATKSGNPVNSEKIKQFALDGITLSGNASYELSMKRREELKPCLNPMYRGLCSRNTPVTEKLFGQDLNGSMKQVAEAFKAGRKLTYSDSNKRAPRHQRYVPYTQRARGNRHGCNAERGSRDQPYGRSSTPSYYANTHSGNRRGGTFGRHQAKPATSTQDRDKKLMPAIQAGELFQKRTIPKFRDSGQSLTRPITSLHSHSTYVESSTVVPTATPHAHRQPNQTTGGLPSTSTPTTDSQPTPGRLGHLREHWKAKGFSIEASNLIANSWRSRTQKQYESAWKGWIGWCYQQKTNPLSPAIADIVNFLAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL59</accession>
    <name>A0A914BL59_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fas apoptotic inhibitory molecule 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076660.1">
        <property type="nucleotide sequence ID" value="XM_038220732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076661.1">
        <property type="nucleotide sequence ID" value="XM_038220733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL59"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220732.1">
        <property type="protein sequence ID" value="XP_038076660.1"/>
        <property type="gene ID" value="LOC119744668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220733.1">
        <property type="protein sequence ID" value="XP_038076661.1"/>
        <property type="gene ID" value="LOC119744668"/>
    </dbReference>
    <dbReference type="GeneID" id="119744668"/>
    <dbReference type="OMA" id="SQEYRIM"/>
    <dbReference type="OrthoDB" id="6262731at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.180:FF:000001">
        <property type="entry name" value="Fas apoptotic inhibitory molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20046" checksum="ED21F60B448E4275" modified="2023-02-22" version="1">MADLVAVWDVALSDGVHKVEFEHGTTSGMRIIRVDNKEVLHRNWMFKLVGREHFKIGAFKASINIDASGGFSYEYTLEVNGKTLKELREQRSKTAKVWLPVIEGYEFRIVLEKDSMDVWCNGQVLETAGEFVDDGTETHFTLPNGLACYIKAVSSGKKKEGIIHSLVINDNEIPETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMC8</accession>
    <name>A0A914BMC8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077095.1">
        <property type="nucleotide sequence ID" value="XM_038221167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221167.1">
        <property type="protein sequence ID" value="XP_038077095.1"/>
        <property type="gene ID" value="LOC119744944"/>
    </dbReference>
    <dbReference type="GeneID" id="119744944"/>
    <dbReference type="OMA" id="MGWARDP"/>
    <dbReference type="OrthoDB" id="10649104at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037777875" evidence="2">
        <location>
            <begin position="23"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="507" mass="54997" checksum="5DC739B611BC5327" modified="2023-02-22" version="1">MKLFCKVVVMATILYLCVLASGKPIVFGLREQTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGHDFEVKEPTALPVESKTGPDFEVKEPTALPVESKAGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVQSKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESETGPDFEVKEPNALPVESETGPDFEVKEPTALPVESKTGPDFEVKEPTALPVQSKTGPDFEVKKPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTALPVESKTGPDFEVKEPTPLPVESKTGPDFEVKEPTGLPVESKTSPDFEVKKPTEISLEEYLKQARLWEWVYEIRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMP7</accession>
    <name>A0A914BMP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077016.1">
        <property type="nucleotide sequence ID" value="XM_038221088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221088.1">
        <property type="protein sequence ID" value="XP_038077016.1"/>
        <property type="gene ID" value="LOC119744896"/>
    </dbReference>
    <dbReference type="GeneID" id="119744896"/>
    <dbReference type="OMA" id="GTVERTW"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037826257" description="Ion transport domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="177"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="481" mass="53678" checksum="89E67EFE1A75B091" modified="2023-02-22" version="1">MHAGSRLTLLCVLIASTSSWVVDLLVMTDFNEVNISGKEVTDLYIASMTRPLTPVSMLILIWIAGMTVRTIKQLWTQGASVYFTNGWNVMDFVQLILYWIFVIAGITAYFKSLDIAEAEGIFARVPDIKQALSGANTSAHTPESATELPGATVTSNNEMQDTEHTWQDFQAQLVSEAAFAIANVLSFLQILHHLLAFALLGPLLVSFTGMAYDVLKFFMIFCCLLVSFSIGMTQLYHKFEALEVKACHLEAETCGDTPFLNFGKSMVTLFWSLFDMVDLGTLRVNDSLVVTNTVGSIMYAAFMLIGSIVLLNALIAMMSNTYTRVEENSEVEWKLARTKIMAEYISEKASLPPPFNLVPTVKFVLWLFRYIPRKLRRSGCPASQQQFRATDQEGLQNAAYKEASLVLGERCLRAMDMERSESQTSSDLKTLKNSVEKFSCEMMRIQQQLTCILEILNQTKGVVETGDCPAEEATIADKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNT2</accession>
    <name>A0A914BNT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activating signal cointegrator 1 complex subunit 3</fullName>
            <ecNumber evidence="16">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="16"/>
    <dbReference type="RefSeq" id="XP_038077615.1">
        <property type="nucleotide sequence ID" value="XM_038221687.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221687.1">
        <property type="protein sequence ID" value="XP_038077615.1"/>
        <property type="gene ID" value="LOC119745375"/>
    </dbReference>
    <dbReference type="GeneID" id="119745375"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000028">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="485"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="698"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1337"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1548"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2200" mass="249252" checksum="A3F2E93CBE36C143" modified="2023-02-22" version="1">MPLPRLTGAIRAFSDVTAEGADSTDHTDISLLRKQTLRAERQARQGLTWTRLSQEIQTLGGHHKSETSSKLHELVHITREMVSSDAPMALVESTAVFLFTKLKNCNELTHKKSTKLHATIGPFPASLGQQALKSIQSLMGLLSSDAREVLERLIRGAESEQEEFGNHIHFSFEPRNLDIGDDNSESEEESEEPILKFGYDAAAAAQPVSKQPQTTASSNANKKSMNLGWLKVQLQGQFGQGGTPLGLTVDALCAKLLGDLTSAKSNDELQNELFDLLGFECFELIQRLLANRSQLVQAASHNQMSQIIAEGKKERQARPVYGSQVIIQSEQEKELNKQLRKEEKRLARQEARGFNAQGDGAGSEPFFDPQYLRMQRERALIDASKAPLLTKRTSGAPKHVYPYVFDALAEAQKTSAFVGAAKVMLPEGFERKNVKMFEEVTIPPSQPAPIAIGQKRVAVSELDEIAQIAFKGTRQLNRIQSIVFETAYYSNENLLICAPTGAGKTNIAMLAILHEIKQHIEQGVIKKDEFKIIYVAPMKALAAEMVRNFGGRLSPLGIAVRELTGDMQLTKSEIAKTQMLVTTPEKWDVVTRKSTGDIALTQLVKLLIIDEVHLLHEDRGAVIESLVARTLRQVESSQSMIRIVGLSATLPNYIDVSRFLNVNPYMGLFFFDGRFRPVPLGQTYIGIKTNNVFQQRQDMDYVCYEKAREMVNKGHQVMVFVHARNATVTTAQSLREIAKTQGDSLMFRPDQNPAFGNAEKQVSKSRNKQLRDLFPDGFSIHHAGMLRQDRTMVERCFRDGHIKVLVCTATLAWGVNLPAHAVIIKGTQLYDANKGVFRDLGILDVMQIFGRAGRPQYDDHGEGIIITSHDKLTHYLSLMTRQNPIESQFIESLEDNLNAEIALGTVSNVEEAVKWLSYTYLYVRMHLNPLAYGVNYKSKENDPGLENFRNELIVKAGRALDKAQMIRFNEATRDFHSTDLGRIASHFYIKYATIETFNELLKPLMTESGVFSMVSQAQEFQQIKVREDEIKELDFHHSSDGSCYMPAAGGVENAHGKVNILLQTYISRGFVESFSLVSDLAYVAQNSARIIRALFEITLRKGWPLMAAQLLTLSKMVDRRLWSFENPLRQFPQLSQEIQRKLENKKLTIDKLREMPASEIGHLIHHLSMGDKIKQCVNQLPCIELEATIQPITRTILRVRLSITPAFRWNDRVHGTASESWWIWVEDPDNNHVYHSEYFLLHKKQALSRETQSLVFTIPIFEPLPSQYYIKAMSDRWLGSETVFPISFQHLILPEKHPPHTSLLDLIPLPITALGRPEFEALYKFTHFNPIQTQIFHTLYHTNHNVLLGAPTGSGKTIAAEIAMFRVFNEQPGMKVVYIAPLKALVRERIEDWKVRLQQQLGKNVIELTGDVMPDIRAIGSADVIVTTPEKWDGVSRSWQTRKYVKAVSLLVIDEIHLLGDERGPVLEVIVSRTNFISSHTEQPLRVIGLSTALANARDLADWLGIKQNGLFNFRPSVRPVPLEVHIQGFPGKHYCPRMATMNKPTFQAIRTHSPMKPTLIFVSSRRQTRLTALDLIAFLAAEDNPKQWLHMEEQKIENLISAIKDTNLKLCLAFGIGMHHAGLHERDRRTVEELFVNQKIQVLIATSTLAWGVNFPAHLVVIKGTEFFDGKTKRYVDFPITDVLQMMGRAGRPQFDDQGTAVIFVHDIKKHFYKKFLYEPFPVESNLLDVLAEHLNAEIVAGTISSKQDAMDYITWTYFFRRLVMNPSYYKLEETDHSSINKYLSFLVERSLLELENCYCLAIGEDNRTIEPLTLGRICSFYYLHHQSVRMFRDSLGPDTSLPELISVLSDAHEYEMLPVRHNEDGINSDLAKKLPLEVNPHSFDSPHTKAHLLLQAHYERQPLPSSDYSTDLKSVLDQSIRIMQAMIDVSADQGWLATALRVMNLVQMTLQGRWLHDNALLTLPHVEHNILHCFKPPTKGKKTNPIQSLPELLAVCRGNRSTLHRMLTPEVSDGQLEEIWKVIQKLPVIQPKLSVRGWWADGGEEEERPLPTTHITGLPKDRDYLPVHADQEYVLQVDLRRLHRQHQGDTKCHAPRFPKSKHEGWFIVLGDLESKELLALKRIGYVKGRNVVQLAFYTPETTGRVIYALYIMSDCYLGMDQQYSVCLDVQEADITAQFNTEVALEDGELDQLVDHFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPC1</accession>
    <name>A0A914BPC1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077337.1">
        <property type="nucleotide sequence ID" value="XM_038221409.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221409.1">
        <property type="protein sequence ID" value="XP_038077337.1"/>
        <property type="gene ID" value="LOC119745185"/>
    </dbReference>
    <dbReference type="GeneID" id="119745185"/>
    <dbReference type="OMA" id="FATEANQ"/>
    <dbReference type="OrthoDB" id="6092644at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1508"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1810" mass="204182" checksum="07A2C1A1FDEF35B3" modified="2023-02-22" version="1">MSIKSEKPSQPDFKEENSLEMPLLSENGNSHSAPQDKAPSLISKRSSASALSSCNSASLKARAKAEAAKVRLEFARKEAELRKQNATQEAALLLLNAERDAAMAEVEAAVLETGQDVGGSSRKSDDLNLPSGGYKERVEQYLSSCKNASKTVDCQGHTQVNDSLTAPSPQHLDSIKVISEVSNMLMKKELVTSGLRMFNDEPGAYKSWKASFKQATAEIKVKPSQEMDLMLKWLGKDSCKLVTPIHSIHVDRPDVGLSRMWNLLDRKYGTPEVVEQDLQQRIEGFPKISHRDSAKLLEYSHLLMEIEYVKDMDNCPGLLHLDSGRGLRPLVEKLPYNLQEKWLMEGARYKDKHQVTFPPFKVFSEFVSYQAKVRNDPSLTTPHDPKQHDATKRTVSVRATEVGNLKQPNAGGEHCPIHKTAHSIVKCRAFLSKNQPQKRAILRNHHLCFKCCMPQHSARECKANVKCDSCGSDQHMSILHNDHQTQSTERLQKPTNAAQPQITSACSKVQGSMCSAGMSCAKIVPVLVKSKRDQGTCVKTYAIIDDQSNKTIATHKLLDKFNIDYGEVNYTLRTCSGEEAVHGRWADDFVVQDIHGTVSVDLPAVTECSLIPDFKDEIPTPDVTKVYDHLKGVNIPEIDNNCTATLLIGRDVSEAHHVLEQRIGPPDTPFAQKLKLGWVIVGEVCLQGIHKGDNHRSKISSLRTQVLFTGRPTFLEPCPNEFQVKHLFDNDSDGVSLSIQEKQFVDLMKREGGLKDGQWTAPLPFKQPRDRLPNNRQQAFKRAQILRKGMERDPTKREHMLTFMEGVISHGHAEVAPPLQPDEECWYLPFFGVYHPKKKDKIRGVFDSSAEFLGHSLNKVLLKGPDLTNDLVGVLMRFRRGRVAVCGDIESMFFCFSVSERHQNFLRFFWHKNNDFNKPLIEFRMRKHVFGNTPSPAVATYGLRDLAKDAEPDVREFINNEFYVDDGLASCDDSDTAISLIKRTRSMLMEKAGVRLHKIASNSQEVLDAFEPEEVQKDIRNLTLSDSVPTQRSLGVLWNICDDTFRFQTDLEERPYTRRGVLSTINGVFDPLGFLAPVMIQARVLFRDMTAHNAGWDDSLPDEYRVVWESWKSGLAELQYLSVPRTYPAHPENGVLHIYCDASEVAVAAVAYLVGAEEPRSGFVFGKSKLAPKAGHTVPRLELCAAVLATEISKVICREMDIQPSGVKYYTDSKIVLGYLTNTTRRFHTYVANRVHKVLNFSRPCQWMYVPTGKNPADCGTRPIATQSLKHSSWLEGPQQQVPVPTEVTSSEFPLVNPEDDIEIRREVKIQVTKTKLEPANLVSRADRFSTWTSLIRAFSLLVHVARSFSTRNEQTQSHVKDVKLKRDVQTMMVRMVQEQFYHQELICLREGTPLPRGSPLLDLSPMLNQDGLICVGGRLRKSSLPVVLKHPVLIPGKSHIARLLVRHYHSVGHPGRQLTESFLREAGFWITGCKRLVSSVIHHCVVCRRLRGKLASQRMADLPEERLKPGPPFTRVGIDCFGPWEVVSRRTRGGTAQSKRWGMIFSCLTSRAVHIEVIEEMSTSSCINALRRFIALRGKVEVFWSDQGSHFVGVMNDKLFQSYLEKNDTQWKLNPPHAPHMGGVWERLIGVTKRILNGILLETKHQSLTHETLVTFMTEVMAIVNARPLVPLTSDPEDTSFLTPSMLLTQKHGSIDEVIVEDSASNMFRAQWKMVQVLADRFWKQWRLRYLQSLQHRRKWINPERNIAVGDVVLLRDKDIRRNQWPLGIVDGVSPGDDGLVRKVNVRLPSTGKTYARPVHELVLLVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPK9</accession>
    <name>A0A914BPK9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sperm-associated antigen 16 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077636.1">
        <property type="nucleotide sequence ID" value="XM_038221708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221708.1">
        <property type="protein sequence ID" value="XP_038077636.1"/>
        <property type="gene ID" value="LOC119745388"/>
    </dbReference>
    <dbReference type="GeneID" id="119745388"/>
    <dbReference type="OMA" id="VSDDETW"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001313">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001413">
        <property type="entry name" value="sperm-associated antigen 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="506"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69316" checksum="C65CB2B238AF3EAF" modified="2023-02-22" version="1">MAAAAGERIGEDGAYYLEQASLPGDSDDEFNYEEVPIDDDFASEPDEDLHAAVRTIQEAQEDQEALMRGERLVPPPVNLRPELVDDFVRNFLVKMGMTRTMDCFQTEWYELQQRGLLNEEDVKTVPDLYTRNQQMDDQVKTLRRDLDKFKNAANKAKDTYVKLRKERDFNRMHHKRVVQEKNKLIDDIKRLKKHYASYEPTLQQLKQKYEMAMKEKMLAKLERDRAVNQVAGLQATLRNLESGSRDSGSLEFSKADRRLMFASGVGPTQSAVRQAREMFSRPRQPDPENMDVTAQPQPRHPDDSEFPVDTGVNPQLTNIKGPSAHLTRTGGFRLTHTIQAHSLAVSGIALHPRKQILATVSDDHTWKMWAIPSGDIIMTGEGHTDWVADCDFHPSGAQLVTASGDATVKIWDFSKAECVHTFTEHQHAVWGCSWHTGGDFIASCSMDNTSKIWDLNSLRCRFTLRGHTDSVNSIIFLPYSNTLLTCSADKTVSLWDARTGICGQTFYGHSHSVNNATFNLKGDTVASCDSYGNVKLWDVRTCAPMASVDVGPHPANRVAFDGSGSVLAIASNDGTTKMFEVASGQVSNLAGHEDAVHSVCFDKSGDFLVSGSSDCTVRIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ11</accession>
    <name>A0A914BQ11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078045.1">
        <property type="nucleotide sequence ID" value="XM_038222117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222117.1">
        <property type="protein sequence ID" value="XP_038078045.1"/>
        <property type="gene ID" value="LOC119745621"/>
    </dbReference>
    <dbReference type="GeneID" id="119745621"/>
    <dbReference type="OMA" id="RYHCKIR"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="447" mass="50760" checksum="05A997B99518B920" modified="2023-02-22" version="1">MARNIRCVLFGLVAVSAICLLLYGRRSGTLVKSVTAVSREGVRQITQDKSNTQEELGIFSRGTNVSSEESSSCPPCNRNPTSIDPVPNGVEEQPVVGDDSVPAEDTRSSDPPGSRIVVLTSMRTGSSFIGEIFGRNDDIFYLFEPGLALLTELHSRGALFLQPMYIDMLRSLYQCNTSSLDFYIKWLSRQPPLEVKKKVPRIFDSLCYPFETGRTGLKCDAIPAEIFERKCQEKRHIAIKSIRIWDIGMFLSLIQDSNVKLKVIHLVRDPRGMTASRVLAMNVVENTFNKLQADSFTDEMRSYLMEFCSYSIDNKEIGYYLPKYRDNYLLLRYEDMSLDPERVTQLIYNFTGLGAVPETISKWIAENTQAHRPGVYSTTRVSSQVYQSWRTKLDYKTAKAIENVGRCAEMMEHFGYLPVRDESHLKNLSSPLLAPIPPPRDSYRYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQM7</accession>
    <name>A0A914BQM7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assembly chaperone of rpl4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038078464.1">
        <property type="nucleotide sequence ID" value="XM_038222536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222536.1">
        <property type="protein sequence ID" value="XP_038078464.1"/>
        <property type="gene ID" value="LOC119745882"/>
    </dbReference>
    <dbReference type="GeneID" id="119745882"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48315" checksum="DC2282701EAD6130" modified="2023-02-22" version="1">MGGTSKVKGRRRSKRGSTRGERKGLKELTKEPKRSGPGKEGRRRSSDKGRETGDAHTKYSVQQLLGQATDCMDTFNYELAQKFLQRALEMEPDNLRVLEVTGNLLVEVGELEKAKQCMGRAITLSPEAGHSKYLYMGQLFEGEEAVQYLVKGIELMKKEKEKQDKQPEAACADNNSSTDRVTDGDIARAYCSMAEIYLTDSCFAEDAEQKCKEYIDKAIDADSDSAEAYQILASYWLSKEDKEQAKKSIEKSLSLWLPKMKALEEEEVNMDGPTLDPINPCPLNYQNRIGTAKILMELEMNEQAEEILEGLLQEDDQVVQVWYMLGLMNVEKTGEEHKAPARFFLNMAKKLYQKIKCDDEQVLMHTEELLTVLGPGEGLDESWPRNQGESSGSDDTEEDVLSSEDEQEGGKTTDGERKGAREGEEQMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BT42</accession>
    <name>A0A914BT42_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038078682.1">
        <property type="nucleotide sequence ID" value="XM_038222754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BT42"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222754.1">
        <property type="protein sequence ID" value="XP_038078682.1"/>
        <property type="gene ID" value="LOC119746004"/>
    </dbReference>
    <dbReference type="GeneID" id="119746004"/>
    <dbReference type="OMA" id="TRCLPCR"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF8">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="177"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="373" mass="43539" checksum="4E3D6E5650FB1693" modified="2023-02-22" version="1">MRLTRCLPCRLLHSLFSSLHNWKNTLIVVLLVSFTVVVIMQKYWMEARLQLLLAYDLSESPTRQQSDSVRTQMSLYVGNESTNSDVGSRIEFYEPSNCPKSISSLPNYSQWFRERFKPNIKLFLDKLDADNIRNLSFYELPFGFKNEKHDFMKSLLLHNNFKNPSLSLRREKQCISCAVVGSGGILNGSRAGREIDAHDLVFRLNAAVTYGKHAEDVGRRTDFYMFFPESAHLYGFMDKNVTLLYTMYKTFDVEYAAEILNINRQRKSQKADPERLKIIHPDFFRYVFAKFLDAKSMKPTTGAVVVMLAVHLCDSVTIYGFGYDPKFSMHYYDSAFIKRTYRSTWTHDVENEKKLWDTLHNEGVIRFFKRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YYS5</accession>
    <name>A0A913YYS5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044718.1">
        <property type="nucleotide sequence ID" value="XM_038188790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YYS5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188790.1">
        <property type="protein sequence ID" value="XP_038044718.1"/>
        <property type="gene ID" value="LOC119719361"/>
    </dbReference>
    <dbReference type="GeneID" id="119719361"/>
    <dbReference type="OMA" id="EHEDAHI"/>
    <dbReference type="OrthoDB" id="6416613at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="41280" checksum="5DAC75E30FE6BAA6" modified="2023-02-22" version="1">MDDEYDEIEYNSTDDSEEAFEFSDYTQRVIVAVLYLIIALLGIVGNTLVIQAVLLSRKLRTATNAFVVSLSVADLLTCLVVPWDAAAMLGMDGPPFGEWVCSVVAVVQSTTIGCSTYTLAAIGLQRLLLITRPVTTYQAIYSQRKIAACMVVTWLIPFLLTLLPPLFGVGEVGYNRKYHHCGFSSSHERSNDYDLIIAGGLYPLPLITIIVCYALIWRHLRRHAERVTSKAEEPADSATMNLSTVSESVATLRRSPTRQGSLDPARVKRSQNEITKNMFYIVCAFLLCLTPFAICLFYDDSDPFLPYAAAFLVFNSCVNPIIYATKHRDFKTVFRCILRRKWDSIPEPSDFLKAMRRKKCCNRGGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3T2</accession>
    <name>A0A913Z3T2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045370.1">
        <property type="nucleotide sequence ID" value="XM_038189442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3T2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189442.1">
        <property type="protein sequence ID" value="XP_038045370.1"/>
        <property type="gene ID" value="LOC119719956"/>
    </dbReference>
    <dbReference type="GeneID" id="119719956"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42103" checksum="9698CB435A082DC9" modified="2023-02-22" version="1">MSVSGRTCQVPNPCFDLTLCPAEGMYCVANIFNPVGYDCVCDALLGYLAEDGGSCTRYIALVFRLRVLGINGVAVIFLPVFSNPTSSASKEALRIILEILLFILKRNPLTSAVRDVTGISILSGGSIIVEFVALYDNTDTALVVPSVQTIQSVLQSQSTLQGESASLAVDTQYVTTEQTTSTCPMNYCANGGTCDVVGLYPMFTLTCRCSTSFTGERCNDSIMGVVPTAPRTDAPTETPGQGVLPAILIIVVLVVVPVVGLLILVFPCVLLRRRNAAFKSPYRHSADVRPDFNRRVWRDEDGTVIAVFPTASQRDQSTRFSARARHEASSYVPQLQQIPPERRSHFMTPYVVLGFEEMQLREFQGPMEHFGDQDWRNPASYGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z485</accession>
    <name>A0A913Z485_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038046643.1">
        <property type="nucleotide sequence ID" value="XM_038190715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z485"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190715.1">
        <property type="protein sequence ID" value="XP_038046643.1"/>
        <property type="gene ID" value="LOC119720854"/>
    </dbReference>
    <dbReference type="GeneID" id="119720854"/>
    <dbReference type="OMA" id="IANISWV"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF499">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="53134" checksum="A284FDCE27F7906B" modified="2023-02-22" version="1">MLRQARVRPAESESPRCATQSVELETVGNQGTRWRLCLCLGLQADTKKKQQRRQVWRMVVMTLIPILALAILAVVLMTNSSADNVRLQWLRNEVGGSVENAGQLIHRLQIERGMTAFYLSSGNREELDNLQGIYEQTDSAIDRISWVNDNSHAAPAFFEHKEYYRAHLIRFRKNLVSPEGINVTISDVMIFYTNDIDIILGWLAMGIKLYDPAGGLWSKLISYQLLLLAKEHTGKERAIGSTFYSRGGFSQNNDFIWFMNESVAGKRFLDIALQFSLFLEEASEGIIDDTVTSQIEDMRSEIHLNNHQLLEPSLAKGDRWFQNMTHFINDLLQLQTKMGNSIIEELNSDMRWSLSYVVAYAFLLSTVLITGPLIIRGIIRQTHRIQQVGDSLHRKTLELREEKMKSDSLLYQMLPKVVAEQLKLTGQTPAESYDEVTVFFSDLVNFTAMSAISTPMQVRFFFFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5Y5</accession>
    <name>A0A913Z5Y5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046421.1">
        <property type="nucleotide sequence ID" value="XM_038190493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5Y5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190493.1">
        <property type="protein sequence ID" value="XP_038046421.1"/>
        <property type="gene ID" value="LOC119720688"/>
    </dbReference>
    <dbReference type="GeneID" id="119720688"/>
    <dbReference type="OMA" id="WAHVEPM"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="16"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="255" mass="28506" checksum="87AB339E9D22139A" modified="2023-02-22" version="1">MEKTPTDQVTTSRIKTFVFLDLETSGIDPIKERPKMTEICLMAIHREALLSSSRENDAAVGRSTDAVGSGMGLPRVVDKLSLCVYPNKQVSDKAFEMTKLDSHSLSQSSKKIFDGDAATMLKLFISRQEGPVCLVAHYGDNFDFRLLRTELQKIGQRMGEDILCADSLEAYKATDGDRAGFVSYALGNIYRRVFGGTIPDAHHAEADVKAMIRIMLTRAETMSKWMDKNAVLFNDTELYYFPSPSEKRRCTPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z782</accession>
    <name>A0A913Z782_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047663.1">
        <property type="nucleotide sequence ID" value="XM_038191735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z782"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191735.1">
        <property type="protein sequence ID" value="XP_038047663.1"/>
        <property type="gene ID" value="LOC119721777"/>
    </dbReference>
    <dbReference type="GeneID" id="119721777"/>
    <dbReference type="OMA" id="WIANIPQ"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="375" mass="42332" checksum="D00C7FA76C32185C" modified="2023-02-22" version="1">MGSGITSGECSERDTVNISQWAVSAWLYTPLDTSITTIVIPILWSLGIITNLTFLFVIVRVPKLRSDTNIYLAHLSLADLLFLNLTSTYSVWRYVDSPVAYHFPFVSTAQCISYFTFTNTGYYASIALVTVVSLERYLALCHPMKHLAIRGRRRTYRMIGICWLVGLLFAVFTSLSQAILHVQCLRWPDDDAYQDYPSSRAYCASVAPWVSYYNPPVLNIPWLIAMVANSYMYVRIVHMLNKRSGQNLVSNGPNAIKIRNQVAKMLVVNGVVFFLCQTPYRIYSLSGWICSLVGIRNPLWLPGISAWIANIPQFINTLINPLIYGAVNRQYRIAFVQAFRCKSHHSTGQHSPSQPTFTTRAASSKPSTVEEDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7D0</accession>
    <name>A0A913Z7D0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047599.1">
        <property type="nucleotide sequence ID" value="XM_038191671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7D0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191671.1">
        <property type="protein sequence ID" value="XP_038047599.1"/>
        <property type="gene ID" value="LOC119721592"/>
    </dbReference>
    <dbReference type="GeneID" id="119721592"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="265" mass="28563" checksum="ED60F0A849E67054" modified="2023-02-22" version="1">MPYKKKTAVRPAGEDADGAPQPKRSRQPVTHRSEPPARRGPEPPARRGRGRGRGRPRTHPNPAPEEIHADEPAILDVHPPRVQLQDELPHANMNNDSVPRPSVITSSSPGGDVPFPRTGPTSRPDPNSVTSSSCGLVENEMRRLLDASLAPGPVWIVGDSIVRWAEAPLSLPLTVMWQGQSGAQLANVGPPLAGERHAGIGTPTQTIINGPPVALQNRRTISGNQRHTTGGPPLQNRQRSTIGNQRLLFPAFVVPNCSQQFFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z811</accession>
    <name>A0A913Z811_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047867.1">
        <property type="nucleotide sequence ID" value="XM_038191939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047868.1">
        <property type="nucleotide sequence ID" value="XM_038191940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z811"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191939.1">
        <property type="protein sequence ID" value="XP_038047867.1"/>
        <property type="gene ID" value="LOC119721970"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191940.1">
        <property type="protein sequence ID" value="XP_038047868.1"/>
        <property type="gene ID" value="LOC119721970"/>
    </dbReference>
    <dbReference type="GeneID" id="119721970"/>
    <dbReference type="OMA" id="NFYEGAA"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="165"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="744" mass="83449" checksum="EFC8B1CE41302FA7" modified="2023-02-22" version="1">MSSDTSSVSEHQGRITEAQLRSRNFQPRVSTPDTDITEHPQQPDITLFCDKCGSFILLRLLQEHRKYHGALATLEYKESQRQRPESAEALLKRRQAVLAKMTRRATQENKPLSMSTLQKINDAYELLKSYLEDTYEDLIQTREMVYPECQGLALTCSAKCARAMGICSHDNQRWKRSMEDTRVFQDYFGNDENKCFFAIYDGHSGRFAADITANDLHHFLLNEMTKFDPTTSCTCTLNMAEHNDLIGYKLDRPKPVVRKDSIRHILHEESHNIIQQIMHTCKENVSKLEVKTNNQPSKKETKSKIPNKRENDPFAEKMEFALRNAYQLVDYILSYGIDEQSRVRWSGCSALTCVIHSTGDMEEDGNQEEDENEMENGKEKQTETDEETQVKELGVLYVANAGNSHAVLCQNGKAVRLTRKHTPQSSHERARVLRAGGSVKDGAHGGRVNGVLDTTRGLGNHGDPLLKAAVLAEPHTLSVTIDSQSEFLILASHGVWEVLSEQEAVSLVQQLMPGQEVSPRQQLAPDDPLRELYGVGGLDLAPSLGMDDQNMDADDEDHLDQSTKTDMDNGNDVPSEQQSTQGEKDSPQINETSNVKESPIPSVAQIKLENASPASDSASNRKDTPKLLEHDHLLPHQTREACPGNAPHDNGYDNISEQTDFDSMISALMENDDGNEADVDTLTELHTIYAQSRLLEVEQGRQTKHEMYRSLAQQMSERLVQSALLGGSKDNITVMVILLPGCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8G8</accession>
    <name>A0A913Z8G8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(12) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047301.1">
        <property type="nucleotide sequence ID" value="XM_038191373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8G8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191373.1">
        <property type="protein sequence ID" value="XP_038047301.1"/>
        <property type="gene ID" value="LOC119721338"/>
    </dbReference>
    <dbReference type="GeneID" id="119721338"/>
    <dbReference type="OMA" id="RFACMRC"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031752">
        <property type="term" value="F:D5 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000004">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000754">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="59"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="191"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="370" mass="42871" checksum="CC6615BCBAD90619" modified="2023-02-22" version="1">MGVVWEHITANMAASVFTCCLSPQEIEAKSKSQAIDKELNKYKSYIRREIKILLLGAGESGKSTFLKQMKIIHGQEFTDEDFKDYRNIIYSNVIKGLKVLQDARSKLQIPWGDPANEEHVAQVMGCDTAQLEPTVFGQFVPNCRALWADSGIQGAYDRRREFQLADSVKYFLDELDRIGKKDYLPTTQDILYARKATKGIVEHVIDIKNVPFRFVDVGGQRSQRQKWFQCFEGVTSILFLVSSSEFDQVLMEDRITNRLVESCNIFETIVNHKYFCKVSIILFLNKTDLLEEKIKVVNLKDYFAAYEGESDDLKQVQAFILLMFDMRRRERTKTLFHHFTTAVDTNNIRYVFYAVRDIILKQNLEGLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z936</accession>
    <name>A0A913Z936_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047385.1">
        <property type="nucleotide sequence ID" value="XM_038191457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z936"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191457.1">
        <property type="protein sequence ID" value="XP_038047385.1"/>
        <property type="gene ID" value="LOC119721393"/>
    </dbReference>
    <dbReference type="GeneID" id="119721393"/>
    <dbReference type="OMA" id="SATWHVK"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.770:FF:000002">
        <property type="entry name" value="recQ-mediated genome instability protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1020">
        <property type="entry name" value="RecQ-mediated genome instability protein 1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032199">
        <property type="entry name" value="RMI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044881">
        <property type="entry name" value="RMI1_N_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16099">
        <property type="entry name" value="RMI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="8">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ-mediated genome instability protein 1 C-terminal OB-fold" evidence="9">
        <location>
            <begin position="636"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="771" mass="84590" checksum="F4BC7509AAF0AC9D" modified="2023-02-22" version="1">MALQVPEVTAFLRSRHVQVVDEWTVECLDWLQQEYQGQNVKPNEMKQYVYDQWLDSDLTEIASPALPPGIAQQRKTQLTGSYVLQINSVQDISTPAYGQLIKLQGKENENVLVTATQATQQTQSKFEQKSSRMLMLQLTDGHQSLEGMEYQPISQLSVNILPGTKILVHGSVQCRMGVLMLTANNVRVLGGDAESLAENNSQIQILSRALGLDGSQQSQQEPVPAASNQRQPAPQSPIDLTGDSEIIRNTSSSTGRSNHNKQRAASHVNEEDGFFSDDLGEDLDALMLNEIERIEEMDQIQQLASSAGEETEWPADEEEIDEMWLEQVEQNHDVQSTDLSKQNATTKNKSNSAPVITRTAPNISTLNQVPQQSRQAQKDAKVKTEPFAARQGNVKQPTLSKINLSSVNSLTSVRHQDLKMESKRPDKEGLGNVFKTNMPDSKGAFSRTKDEPSANRSTNVSSNTKIGNNPRTSDQHAHRDIPSKANLDSKKTLDYKVPTVPQFLKNKETAGPETKPLVDFQQKAQSSEPSTSSSDPITNFLNLRTGVAKPAPATGIAARITKEPPQGKWDNNAKISSLAATVQSSTSGSEDTETSFEEGLSAAKRRRFRSNEGGWADRGMASSSIVALSSVMGRIQAQDIFTFTIKGFVVTLISALSKNDGHWSISAKISDKSATLDVDLSNEVLTGLIGFSVTEMIQLKKTIKTSDPVKAKELETKLRQGLAQCQKSLINMHCTLTVQVRSNQERPLVIAVGKTDPADLATNFREVPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAB9</accession>
    <name>A0A913ZAB9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048712.1">
        <property type="nucleotide sequence ID" value="XM_038192784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038048713.1">
        <property type="nucleotide sequence ID" value="XM_038192785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192784.1">
        <property type="protein sequence ID" value="XP_038048712.1"/>
        <property type="gene ID" value="LOC119722601"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192785.1">
        <property type="protein sequence ID" value="XP_038048713.1"/>
        <property type="gene ID" value="LOC119722601"/>
    </dbReference>
    <dbReference type="GeneID" id="119722601"/>
    <dbReference type="OrthoDB" id="10046764at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08031">
        <property type="entry name" value="LARP_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="839"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="839"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="941" mass="104327" checksum="47D6AF95E383CAF5" modified="2023-02-22" version="1">MTTDRSNDGDDLSSSTVSAIPKKTTLNPNAKVFQSPKLANSVTSSADSTDSSPDWHDNENRSSQASSPQTAMTTQGPYQMNGDVGKFSALGYPPSPESPVYSIQNGYISGPEYPYLPDGQLVTSDDLSQQELPKGEDLRKLLQRQLEYYFSRENLANDRYLQSQMDADQYVPISTIANFNAVKKLTKDMPLIVEVLRESSCVKVDDKGEMVRPNHKRCTVILREVSQATPLEDVKALFTGENCPKFVSCEFAHNSNWYITFESDTDAQKAYRYIREEVGIFQGKPIMARIKAKPLQRINFSPKPAPVNGYTNTSQQMYTQQFQYPPSQHVNSISQQPSQQQQQQQSSQQQQQQQQQQQQQQQQQQQQQSQSQQQQQQQQQYPFYSTGVGQSQTWGVTSPTYFEPPPMQQPQAFSPGAFPPPPPPPPPQNKFQTINVNRQHAYQGPRSRTHQKSHSRTSSTPELRSTDRVSNSMFQENSIHRSHSERRTTPNGPQVVSPRGVFDSLRGGEGAMDRRDDKERDREREIAYGRRRDVPPVTTLPTSSSSTASRSRYQEETSSSSSNSLQQNSRGPRVSANYRDRRPRRREDDIQNRRNSRDLRDSRDKEQPAPTPKEVPKPPSPQIDLASFPPLPGRTITENEACEKKEEETNNNDLVTPMADIVKGVKDPKVQRAAKSQEPSKPNHPATKDSATNTSSIGDGKEQSPSSAAVKTPTSLPRKQTQVPVATQTDLDLSASPEAIPTPTTTQHPAKVSQTTSTAVNTTVTASASSAAAIVARTTITTVTGSTQTVSTGSQTADSQSSQTCSASCSTSTTTQATECLVPRLSYAAVIARRAAKANAVSTNATVSQASTPTTTTSTLTTNSNESSIPPRQGQLSQASTVLQTQQPPYPHTQAPNKSFRPRYGMRANDREANYEPSSRYRREYYTGRRSPPQPRQMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEP2</accession>
    <name>A0A913ZEP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050258.1">
        <property type="nucleotide sequence ID" value="XM_038194330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194330.1">
        <property type="protein sequence ID" value="XP_038050258.1"/>
        <property type="gene ID" value="LOC119723599"/>
    </dbReference>
    <dbReference type="GeneID" id="119723599"/>
    <dbReference type="OMA" id="VEECYIL"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="526" mass="56663" checksum="8CCEA4BB8369D4D4" modified="2023-02-22" version="1">MANRVNNGTSPTNGHQRPMASVTKATGSSPRRPRPASYHQELSSSSSGSPKSSSEALKRSSVTSPVRGRDQATASLALKIPPRVDKTYRRSGSPGARSSASGSSTGSSDSLPSRKATVTLKKLATMREEDKLIDLNLVFYGGEIKCHRIVLAASSPYFRDMLAVSSHLSRHDSIEMRGVDMQVMRALVDYAYTSTITIGYDRVKTLLEAANMFQFQSVIDACVDYLKRSRRKIRQRSSSRQRSETAGGRSPSSGGSPRSGSPRTTPVQSPRAASPLTTPSPLLPSPREPFNGSSPKIAVINDKVGDDVAKILQDVSLGGNGGTINDEEVDGLMKNNGLSSALGVGPKYSRSVSTGSEGYLTSSIGSDSSTESSTHFVFHDNRHPSRLIREMVKLRQAARLTDVVLRTKIKDFPCHRLLLEASSSYLSRVISQDLDGTNAMDVHMKRISSDVLQKLIHSMYTGRVAVSDRDAAQVYRAAKRFGLEEVCHACAVVDPSLDSTSTANTSLTDSMLSGATNADSLENSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZES3</accession>
    <name>A0A913ZES3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038050287.1">
        <property type="nucleotide sequence ID" value="XM_038194359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZES3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194359.1">
        <property type="protein sequence ID" value="XP_038050287.1"/>
        <property type="gene ID" value="LOC119723615"/>
    </dbReference>
    <dbReference type="GeneID" id="119723615"/>
    <dbReference type="OMA" id="YRHYRNY"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="41163" checksum="941446D06DC83DB4" modified="2023-02-22" version="1">MAEPEAGTQKMKSEETSSDMSESHVKVMGMELAPLHIPLHRRLETLAVLQWELTFLLLGVVVVLASIFFLFTQYYPVVLLAYLWVYYDRETPRRGGRRYEWIRRWRVWVHMRNFFPIHLIKTADLDPGKNHLLGFHPHGIMSMGAFVNFGTEANGFAEKFPAIKPFVLTLTGWFKLPLAREYIMMGGGCDVSRESLDWLLGQSGPGNAVVIVVGGATESLEAQPHRYVVYLNRRKGFIRKALQHGASLVPVYSFGETDVYVQLPNPQGSFLRKLQTRLTKAIGFAPPIFHGRGIFNYSMGLLPYRKPIYTVVGKPIPLEKNPSPTQEEIDKIHAEYVASLVALFDEHKTKYGIEEKETLNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFH8</accession>
    <name>A0A913ZFH8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049725.1">
        <property type="nucleotide sequence ID" value="XM_038193797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193797.1">
        <property type="protein sequence ID" value="XP_038049725.1"/>
        <property type="gene ID" value="LOC119723233"/>
    </dbReference>
    <dbReference type="GeneID" id="119723233"/>
    <dbReference type="OMA" id="SICGANE"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000113">
        <property type="entry name" value="Potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF14">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="14">
        <location>
            <begin position="424"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="556" mass="63393" checksum="25344B766898AB26" modified="2023-02-22" version="1">MRSKHDHRIIDAQARHHLGDWGCKPTWDKKHEPIFSTVLACLIFSVLSTIPSCQFAEGVLFYMEIILVMFFSCEYLVRMWSAGCRQQYQGLRGRFKFGRKPILIIDLIVVVASAAVLCFGSEGHVFAASAIRGVRCLQILRMLHMDRQGGTWKLLGSVVFIHRQELITTLYIGFLMLIFVSYFVYLAERDNQDERGRKQFETYADALWWGVVTLTTIGYGDKVPITWLGKIIASCFSIFSISFFALPSGILGSGFALKVQHKQRQKHFSRQIPAAARLIQCAWRCHAAESTTDFISEATWKIHIAPPNANSTATPTAPSTPAFVNKTHLLKKRKNSKLKEALVQSTLLEFIPSKSSPEKTTGVNDTVFSEDPSSVFDRLNRRRLDGDREPSERYRPLQRLSEMFSMDLPDPESDIFSFAYVPETVTSLTPTHKIAIRAIRRIQYLVARKKFQQARKPIDVRDVIEQYSQGHMNMMVRIKELQRRLDQTVGKPGAYLTIDKRKQTILARMSMMENQMYVMDSKLDGCLKLLSTVAKKLEEQNGGQDSPRLEPAQSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHZ8</accession>
    <name>A0A913ZHZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050670.1">
        <property type="nucleotide sequence ID" value="XM_038194742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194742.1">
        <property type="protein sequence ID" value="XP_038050670.1"/>
        <property type="gene ID" value="LOC119723861"/>
    </dbReference>
    <dbReference type="GeneID" id="119723861"/>
    <dbReference type="OMA" id="WGISSET"/>
    <dbReference type="OrthoDB" id="10125800at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="499" mass="55521" checksum="6E4D1515BACFF7AF" modified="2023-02-22" version="1">MTDIMSQSELKWGISSETGSMDQPPAKRPLSPDDTGSASYKSQKSVSDVLGPEMAQIHLIAGGEAAPNHGVEERVSPALLSEAAALMGAGMETMNDGEGLDEIHAEGDSHRVKNLIQIFEHSGQEEASQEESFNGCIEVEERISSSTATEEEFLPGRIIAKTVHKVKEAVKIVGHTVVEGVKKGVQDLRHDFEIGLEKFHLPQSSLEHRPDNNVHVRHPDKLIGGMVGLGMHIQKDAKGHLVHSVIPDGLAAKSKLQENDIIVSVNENDVTSWEFEELQQFFGSLEEVDFKIVVEREQEDEGGAFVCHKVTISIKILLEGDQVMVDIDVKVHVSQLQFNGESEPYYIFQNQSDHSTKYLILKNNCFCMSTANDLTPCRFKRFYYSYGAMAFININNNSPLDHGEPSRIGVNSSELTDKISEFWTDDRIFFTGRQDNTAMYTFQLASQKDFYLTTDAKGNLTTTFFSDKEAVDASGQFSMEPKSKIDKMTPSDIQKYNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKN5</accession>
    <name>A0A913ZKN5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_038051884.1">
        <property type="nucleotide sequence ID" value="XM_038195956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKN5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195956.1">
        <property type="protein sequence ID" value="XP_038051884.1"/>
        <property type="gene ID" value="LOC119724752"/>
    </dbReference>
    <dbReference type="GeneID" id="119724752"/>
    <dbReference type="OMA" id="PYFQGFA"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="46349" checksum="96018303DF14824E" modified="2023-02-22" version="1">MSLVQLLPRRWAWRLCRHWFPQLFLLLCFVYLTFYAVTQFEFDAPVNLNRPKSIRQYEDFPWMKDNILQVKKPPSAADDVPGPAQAHNESLAQEKGKQNGGQDSKEAFNKEFEPNGFMEQQEAIQMERRSHLDQACSKHAKLSQGSLNMETLRHIYVHEKHKILYCFVPKVGCSNWKRVLMVLSGLRKGTVGISSNEAHFKNGMKRLSALTPAEQKIRLKTYTKFMYARQPFLRILSAYKNKFADIKMYRKEPYFQGFAKRIMKTYRKGATARELQTGENITWHEWMTYLTNPTERAGFDDHWQEIYKMCSPCKVKYDYFGKLETINDDARYMLTSLDLQDQVSFPAKANSHPTNSSKTYDDYFSQVPKATLKRLWELYELDFELFGYSKPDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLR9</accession>
    <name>A0A913ZLR9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052717.1">
        <property type="nucleotide sequence ID" value="XM_038196789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196789.1">
        <property type="protein sequence ID" value="XP_038052717.1"/>
        <property type="gene ID" value="LOC119725384"/>
    </dbReference>
    <dbReference type="GeneID" id="119725384"/>
    <dbReference type="OMA" id="PHCYRRS"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18541" checksum="118B13EC4FDF05B6" modified="2023-02-22" version="1">MRQLLGENTLEDNILKQLFLQRLPTTIQGILASTSTAVNIEQLADIDDKIVEVSVPTVSTVNTHAAAVSSPEPAHTVANFQTLETRINQLTEQVQALTGQLSRQTRQRSRSRDTSNHNRQSRSRSPSRDPTDCWYHWRYGSKARKCVQPCSFKTNPNPQGNAEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN28</accession>
    <name>A0A913ZN28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reelin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect defense protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052769.1">
        <property type="nucleotide sequence ID" value="XM_038196841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZN28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196841.1">
        <property type="protein sequence ID" value="XP_038052769.1"/>
        <property type="gene ID" value="LOC119725435"/>
    </dbReference>
    <dbReference type="GeneID" id="119725435"/>
    <dbReference type="OMA" id="QHRMTIL"/>
    <dbReference type="OrthoDB" id="6418377at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037526139" description="Reelin domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="11">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="124" mass="12861" checksum="BB0D7484B286C678" modified="2023-02-22" version="1">MIFAILVCLVPAALGNSAGPPGSSNPSLCTDMIPTGHNGGVSMATDQDNPPYAIDTSSSEYTPNGSLTVTIRGLGGNQFKGFFIQARRADPARDNEVAVGTFSSAPATTQLLFCHNVAHVRNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNY1</accession>
    <name>A0A913ZNY1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052815.1">
        <property type="nucleotide sequence ID" value="XM_038196887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196887.1">
        <property type="protein sequence ID" value="XP_038052815.1"/>
        <property type="gene ID" value="LOC119725479"/>
    </dbReference>
    <dbReference type="GeneID" id="119725479"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="169" mass="19804" checksum="731227BE75D450CB" modified="2023-02-22" version="1">MPQKTIQQLNAYIKATAVVYDHSNAKVISRKTKVKPRRKQAFLSVLHYRKTSSDDCYAKRKPSKQRIKYESQSNTRDEQQKLQVFVRTPPSHKPKTLYFELHPETSVSSFKEVIQKRIGVEARYQRLYIRETFHLSDLLTLENHGVDKNDIITLRLSKDDEDNDDVPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPN4</accession>
    <name>A0A913ZPN4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Di-N-acetylchitobiase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053090.1">
        <property type="nucleotide sequence ID" value="XM_038197162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197162.1">
        <property type="protein sequence ID" value="XP_038053090.1"/>
        <property type="gene ID" value="LOC119725666"/>
    </dbReference>
    <dbReference type="GeneID" id="119725666"/>
    <dbReference type="OMA" id="CKPISTQ"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000006">
        <property type="entry name" value="Chitobiase, di-N-acetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000250">
        <property type="entry name" value="Probable di-N-acetylchitobiase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051887">
        <property type="entry name" value="GH18_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46290:SF1">
        <property type="entry name" value="DI-N-ACETYLCHITOBIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037711251" description="Di-N-acetylchitobiase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="41988" checksum="1B891A903AF1249F" modified="2023-02-22" version="1">MASFSLVLAALIVCFAVFLADPGLGFSGSTEDGGCPCSDPSHCKVISTQPRKEVFAFWVGSTTWKHYDWTRITTIVMFHRHNPQLMCYAHSKGVRVVSMGIFPAANLSSVADRSAWVMAEVNEAIEQYLDGINIDIEYPMNKSEAHLLTNLVAETAHAFHISIPNSQVTYDVAWSPDCIDERCYDYKGIAEVCDFVFIMAYSEQSQIYGPCIAMANGPYNKTVRGVQGYLKLGIPPDKLVLGLSWDGVDYVCQKVSKDNVCSIERVPFRGAPCSDIPAKERTFAFIMTKLVDSTTGRLYNATYASPYYNYKTNVPGQIRQVWYDDVGSLTLRYEYAKSANLRGVGMWPVDSLNYTQTPAAENQTRAMWEAIDTFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS87</accession>
    <name>A0A913ZS87_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM72A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054497.1">
        <property type="nucleotide sequence ID" value="XM_038198569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS87"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198569.1">
        <property type="protein sequence ID" value="XP_038054497.1"/>
        <property type="gene ID" value="LOC119726738"/>
    </dbReference>
    <dbReference type="GeneID" id="119726738"/>
    <dbReference type="OMA" id="HLWIFNS"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16916" checksum="63C77A9BD1742E53" modified="2023-02-22" version="1">MHPSFRKKHVIKLLCRFCDSYVCRRGMKAVLLADTAVELYSTDSPISGKVSSVGKSYSTKKCTCKICDVACTSCGNILGYHVMLPCTSCLQSCNNGHLWIFNSNTVWAESRLNQSATEMLKWDSLPDAASEQDSELDEWDNYFQEMECCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT37</accession>
    <name>A0A913ZT37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054241.1">
        <property type="nucleotide sequence ID" value="XM_038198313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198313.1">
        <property type="protein sequence ID" value="XP_038054241.1"/>
        <property type="gene ID" value="LOC119726576"/>
    </dbReference>
    <dbReference type="GeneID" id="119726576"/>
    <dbReference type="OMA" id="IPFFICK"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037401775" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="165" mass="18476" checksum="63BD93579C703046" modified="2023-02-22" version="1">MAFRKISCVMFFLVLGLVSADDCPPFWTRYGNYCYRFFGPPKTWQSAEEHCREFFTRNGQGHLASVHSSGENNFLLQMWSSSLLPKEGIVAAAIWIGHSDLANEGQFTWSDGTSFDYNGGWRTGQPNDSGQGEDCGSIYRTTQQVGWNDGPCGSAHPYLCKMPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWG4</accession>
    <name>A0A913ZWG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055993.1">
        <property type="nucleotide sequence ID" value="XM_038200065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200065.1">
        <property type="protein sequence ID" value="XP_038055993.1"/>
        <property type="gene ID" value="LOC119727984"/>
    </dbReference>
    <dbReference type="GeneID" id="119727984"/>
    <dbReference type="OMA" id="HESFTNE"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="453" mass="49111" checksum="78B24ECDD2ED536F" modified="2023-02-22" version="1">MSSPENGPVNNYDHDKYGWVMVAVTFLNWAVIMGNIKALGVLLIPITRDLDSELWLIGWLAVLYILMQFCLGPIVGALCRLLGVRPMMVFGAVLLTLGIILTAISPNVFAMAVFIVGLAGVGSALILFVSFAVMASYFKKKYALAVGLSTMGIPVGVMAYGPVTQMLVDTYGWRGTMLLLGGFSFHLVACSMLVRRNASSSADTEQYQEVTQSDEEENCPSEDGSFRGTNRTNISSDTRQTLSGGWARVCCQSVLKAFDFAVLTDMQFILVVSSRCAPTFAYSGVVVYMVSHGQLQGLSEMQASFLPTSFGSGNIIGKLVMPLLQQMGIKVSMTFWACFASCVVCVSLLLDAFVTPFMGQMVVTGLLGVGYGISIQAMDVIVRFIFTDDRLVNVLGWQGFCTGMAAGLGGLVAGWIYEWTGSFNIAFYLYGGVTLISIPLLLFQDLYAKRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWY5</accession>
    <name>A0A913ZWY5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056057.1">
        <property type="nucleotide sequence ID" value="XM_038200129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200129.1">
        <property type="protein sequence ID" value="XP_038056057.1"/>
        <property type="gene ID" value="LOC119728053"/>
    </dbReference>
    <dbReference type="GeneID" id="119728053"/>
    <dbReference type="OMA" id="ELWIRCR"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="135" mass="15553" checksum="C0620240B31FFECE" modified="2023-02-22" version="1">MTVGVFQTLLAVRPPGWLAWQDACYILLPDKMNWWQGEDVCDRPGSSLVVPDSQEEQDFIWREMKARIQAFGANISSDLELWIRCRDVDNKGALSCYGVDGDPDYKNWGHDEPNKFEHICVRMAEKFNGQWGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXZ1</accession>
    <name>A0A913ZXZ1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055921.1">
        <property type="nucleotide sequence ID" value="XM_038199993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199993.1">
        <property type="protein sequence ID" value="XP_038055921.1"/>
        <property type="gene ID" value="LOC119727914"/>
    </dbReference>
    <dbReference type="GeneID" id="119727914"/>
    <dbReference type="OMA" id="IHAARDC"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF191">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="45763" checksum="92190E7E86DF8245" modified="2023-02-22" version="1">MSHNNSSNVGLSSTLHRKWKADCSEIVKGNEAEIKRVVRILSHQRMIINHKPKKPLMPLDIDVLRWTQDCTTFRRIGDYPQYPLSEEESAFPIAYIMVVHKQSAQVERLLRAIYQPQNIYCIHIDNKSPEDFKGAVAGFARYFENVFVASRTVSVQYAGFTRLLADINCMKDLTGPTALGYPWKYVINLSGQDFPLKSNLEIVRKLQSYDGHNDICVDEPPSYKRKWTGYHHVVEDGHVVRTRQRKEPAPHNMTVYAGLAYYIASRRFVDYVLNNQTAKDLLEWTKDTYSPDENYWATLQAAKGTPGGRWQAPNGTAVRFIRWFGRYKVPVCRGHTIRSICVFSMGYVQYLVSQIHLFANKFDYTFDPVALQCLEEHIENNTRHTITNHESTVSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZK2</accession>
    <name>A0A913ZZK2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057063.1">
        <property type="nucleotide sequence ID" value="XM_038201135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201135.1">
        <property type="protein sequence ID" value="XP_038057063.1"/>
        <property type="gene ID" value="LOC119728756"/>
    </dbReference>
    <dbReference type="GeneID" id="119728756"/>
    <dbReference type="OMA" id="WYSAGYS"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="673" mass="75057" checksum="E61A7AEAB89B558A" modified="2023-02-22" version="1">MEAIPIGHCEEKSGKSYDGTIEQGIEGTHEPDMETDKGIKGDMDATGSDSASRGKWTGKLDFILSSMGYAIGLGNVWRFPYLCYSNGGGAFLFPYLIMLLLIGFPMLFLEISFGQFGSLGCISVWRISPLFKGIGFGMVLMSAYFCLYYNIIIAYSTYYMFASVLNPLPWVGCNHTDFNTEACFAASQGDDLKECPFELVNYTANNTRPIFASEEYFKHRVLKMTDSLGDMGTIQWEILLCFIFAWLLTFICISRGIKTSGKVVYFTATFPYVALIALLIIGALQPGAINGILYFITPQFDKLKDVQVWKAAANQVVFSFGAGWGGLQTLASYNKFHNNTLRDVIAIVLGGALTSILAGFVVFSIIGFMACDAKVPIENAIDAGPGLAFVAYPEAVSRIPVVPQLWSFIFFFMLITLGLDSQFVTVETIITAVMDEASDFLPNIRKKKTWIIFTVCFLMFLIGLPFTMNGGIYLMTLFDWYSAGYSPMLLALTELCVFNFIYGQERFLREIGFMIGINNEIWKVFWKIMWYLITPVLIIFPTVYGFVEYTPASYAGYIFPGWAEAIGWTMTCSSLMCIIIYAIYYLIFKVEGTLLERVKLAIRSSPEWGPAQDKDRAEVGYPPMPKRSRPGEGDIMGLDVGHTNSVFVGDQDVKPPSYTEVTGPETVHVETQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A112</accession>
    <name>A0A914A112_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stathmin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stathmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057568.1">
        <property type="nucleotide sequence ID" value="XM_038201640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A112"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201640.1">
        <property type="protein sequence ID" value="XP_038057568.1"/>
        <property type="gene ID" value="LOC119729123"/>
    </dbReference>
    <dbReference type="GeneID" id="119729123"/>
    <dbReference type="OMA" id="CNFMKSA"/>
    <dbReference type="OrthoDB" id="10522323at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF1">
        <property type="entry name" value="STATHMIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="152" mass="17549" checksum="799C1B2D4C870D74" modified="2023-02-22" version="1">MQTADMPSEIKKNSGVAFELVFKEPSKEAIKSPGQSPSTKPSTLEEIQKKQQAAKERREQQERERLKLVAVTNSKLEESKAIRKEKEEQYRKEAEEKLEGKFKKHKENTLAQEEAREEKQKELNEKQARVLAKKKELIETEGTTAPDLNRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A193</accession>
    <name>A0A914A193_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057414.1">
        <property type="nucleotide sequence ID" value="XM_038201486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A193"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201486.1">
        <property type="protein sequence ID" value="XP_038057414.1"/>
        <property type="gene ID" value="LOC119729005"/>
    </dbReference>
    <dbReference type="GeneID" id="119729005"/>
    <dbReference type="OrthoDB" id="10044191at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037410173" evidence="1">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="276" mass="28752" checksum="96AE28A973BA6A6A" modified="2023-02-22" version="1">MGAHFKWITFVVMAGWLSGSQADFCNSSSISSYDCVTNGDESAATFDSCNRSNTCINPGRPTVATGECNGVTTQICSTVRIPYDPPLKDSCSSSPCAEGGKCISQREGVLCCYCNPATPPASDPACYDPAIVSVSSRTPCAAKDGAPPTIDSCNDVRTSKTVVSEIISDLDVKATDNVNNSLPIHCVETSGALNLTSNDATFNCTATDTAGGEATCTFNVVLELQTELPNMSTSELPNMSTSLPPMTGGTCSTSSSVYYTSLLLGATWLVGFLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A275</accession>
    <name>A0A914A275_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057948.1">
        <property type="nucleotide sequence ID" value="XM_038202020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A275"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202020.1">
        <property type="protein sequence ID" value="XP_038057948.1"/>
        <property type="gene ID" value="LOC119729437"/>
    </dbReference>
    <dbReference type="GeneID" id="119729437"/>
    <dbReference type="OMA" id="GGFHCFH"/>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="506"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="635" mass="71967" checksum="2DCBD07C6F54B9A1" modified="2023-02-22" version="1">MAAHRADAEGEIVYACISNIPHEFHSKNLRNYFSQFLEVGGFQCFHFIHRPEAKISENGFKTAASYHSTTSNVTASDDVTSGKVRTVDSSCRTFDEECEEGFPRQNTGDIEIKTRKNKKGSALNTGAKQQTTTCCVISLTESNFGKLMKMYSGKNWVDSESSVMAQLCHISRIKVVDEDIDKEPPRSSRQALSKSSIRKQEGIAMISGTMSRSMLQKLRELHPPDVMPNGNVGTPTSVFSQLIKECRLPPRVINQLGIVFPKSRSNKRYGNVAYVYDGEIYVAEEEEEVEKDVATGSGYTLRRDKRTCLSQNQVSNQVQDKKKKKKERKHSKTKKQKTGLDNISSSNNCLSPPKSDKDDDSGEEWDRHEALHNDVTNQERTTERLFESEMEVTWDKGSSGLVFYTDAAFWDKQDGDFDEKTADDWDVDMSGYNDPDGGDKDARDFIQMREQQRRLEGVEIVSAFSPDKFNKKEMRERRRRARLRDEMDKRIAEDLARPMGEFEKHSKGFGRKLMEAQGWKEGEGLGKDGNKGMESALHNEGQNSFDKRGIGYYGKQLSPTKSSQPAFKRPKKGKRAVLISTIYDDPEVTDPMERLLRSQGPNSLKFRNNVNFTKAAGTDLKRLHSVPEKEKPTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3B4</accession>
    <name>A0A914A3B4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058323.1">
        <property type="nucleotide sequence ID" value="XM_038202395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3B4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202395.1">
        <property type="protein sequence ID" value="XP_038058323.1"/>
        <property type="gene ID" value="LOC119729707"/>
    </dbReference>
    <dbReference type="GeneID" id="119729707"/>
    <dbReference type="OMA" id="HGKMYRY"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF2">
        <property type="entry name" value="GH08893P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43836" checksum="12DAA06BA7E9D0C0" modified="2023-02-22" version="1">MTRVHIKTAGHMIDTAVVSVNKLGKMAGSSSSKCSFALTLVCLFFQFFVSCAGQGDDVITAQEINADTFERKMEAGNFLLVNFIGPGCKNCKDFTPIFNQVNTELLRAKSDVTAAVINNLDIVQHYDLQKLPSLVFFRKTVPILYEGHHEVEEILAWLSNTRELQGRYLNDNDFEHLTQASTGATTGDWLVQFCDPERPQCIALQTMWETVAYRLKDRLNVATVDTSVNKALVKRFKISVDKTPSVILFHKGNQYPYGLFHFGIASLAHFAEQSYKHVQGSPVLPPPAPLMKDEKMYKIHYKMINGPAERLETWLSTGHKTNKANKVPRERTRVDDLTEDIAKKLKAVQPESKGIFFLIFGGLLVFVLVLCKVFMTSPNRQSGTGGGPKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3N6</accession>
    <name>A0A914A3N6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="10">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038057991.1">
        <property type="nucleotide sequence ID" value="XM_038202063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3N6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202063.1">
        <property type="protein sequence ID" value="XP_038057991.1"/>
        <property type="gene ID" value="LOC119729493"/>
    </dbReference>
    <dbReference type="GeneID" id="119729493"/>
    <dbReference type="CTD" id="2241"/>
    <dbReference type="OMA" id="QEHYHES"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000212">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="214"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="676"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="781"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="313"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="534"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116113" checksum="4A940C5081237B87" modified="2023-02-22" version="1">MSVNELRAKFGAPPPLPGPRVKSSVVTTPAPGPALPPPNPGTGSGNSRPTPPDIKKLPPKLGTSKFSFGNSKGQAEETVKEDPALTEDFYLQADEARGATSPKSANFVSPAPSPSPNPTPGPRLPPPRKLSAKTIPVASPLHRTPSHSSAEARFNGRGGGSGDGVFSRSPAASSPKESSNASLEFQYYASEDVVNPLFWEGTHDVEEVRGASRMGFGTDLQDKTAHDIILKLNDQELKLMETLKRVVQHKIKADKEYATSLGLIGGLANRFEEDSQIQHKGFAVKAWSNIIKETDSVSKLIRQHADEMNTAIVDKLSNMIKEKMDLKKQYMQERTKIDMDYMKVKGEVKDSLARYQKAAKEAKDAKAKYEESIIKAKPKDIDKAKDRYKKTVLKVHKCHNEYVLALKAATLHQEHYRTSILPRLLECLQQSQESQIAQVKQTMSDLANLSSTCTGDFVASQNAVMRSIADLRPDREYSNFVENHKVESPAREYFEFDSSVMEEFPDGLEANTIVVDNLTLESAQHTKTSLSESLDEVREVLTTKKQELQSLDEEIRAIPPSPTVEEVLLDLLSKQKRYRDVSREIQDLKCQEAKLNAQVCMLDQKLPAMGEEDNLPPGIELSDTPVVTPNTMPKSNTLSTPGEKTKKLGRITTFFNRGGDSEQKVPSEIPIADEEWYHGALPRPETEELLVNDGDFLVREKSDASGQYVLSARTNSRIRHFPIITNEDNMYRLEGTAFSTVGHLIRHQLSTGTPVTKNSQACLIHPVVKVRDEHDLRHEEIELKDKLGAGHFGDVFRGKLKKDGTPVAVKTCKETVDAATRRKFLMEANILKQYHHDNIVKLIGVCTDKHPIYIVMELVPGGDLLSFLRNDANDISTKQMVKMAEDTGAGMAFLEAKNCIHRDLAARNCLVGHKNIIKISDFGMSREDDVYTIKGGAMRQIPIKWTAPEAMNYGKYTTMSDVWSFGILLYEVFSHGSSPYPGLNNTEARDKVEQGYRMPAPQGTPQEIYTLMCRCWEYHDENRPKFKEVHSILKKLTHTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5Q6</accession>
    <name>A0A914A5Q6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-glutamyltranspeptidase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059138.1">
        <property type="nucleotide sequence ID" value="XM_038203210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5Q6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203210.1">
        <property type="protein sequence ID" value="XP_038059138.1"/>
        <property type="gene ID" value="LOC119730356"/>
    </dbReference>
    <dbReference type="GeneID" id="119730356"/>
    <dbReference type="OMA" id="IMERYEM"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="566"/>
            <end position="567"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="73111" checksum="C3CE84864D957658" modified="2023-02-22" version="1">MYIFAIARRTSTTDGTEASTSAGTNQAAGMENDGYQNGDETPKHDSEPTTKTGEPQGYDDVDLSISAHQQGGKTKYDVEAAGKKKSAKNRTEDEHKVPSYWFIFMVVLLGVGFFLALGLGLGLGHPDPKLKPYQFFNGAVASDRELCSRVGRDLMLNGGNALDAAIGTSFCVGVLNLHVGGVGGGGYLTFYNKTGTVAGAIKTVAVDGQVVAPSSASMDMFSGQEGSAVKGGMAIAIPGQVAGLFRAHKNHGGTLSWASLVEPSIRLAKGGFEIGEALAKAIKDNEDVIRNDTGLSEIFLTSAGGIKQQGDEVTLPKLAATLETIASQGADGFYKGDLANMIVDDVNEMVGGNISLADLEEYEARSADTVSIELGGGQLYDVGGIMVYAPPPPSSGILTNYILNILEGYSLSWRSTGDTSTEVETYHRMLESFKFALAEHSRLGDPEFEDSVKEVMGILGRTSTATTTRGKIQTDALQFLEYGSMYAPKMDPAGGATHISVKDGAGNAVSYTSSLSLDFGAKKRGTRTGIIFNAGMGDFTLPDESLVEGLSPSPVNSIQPGKRPLSSMSPLVLVDKDYEVKAVIGSSGGLEMITATAMMAAQTVWFEHNVIDAMERARFSTDLGVDSATKSVTYNHEASLETGVVNGLSSRGQIVNSVPLMSSVNYIMQTKKNRWYTNSDTRAPGSGYAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6S1</accession>
    <name>A0A914A6S1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059111.1">
        <property type="nucleotide sequence ID" value="XM_038203183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6S1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203183.1">
        <property type="protein sequence ID" value="XP_038059111.1"/>
        <property type="gene ID" value="LOC119730338"/>
    </dbReference>
    <dbReference type="GeneID" id="119730338"/>
    <dbReference type="OMA" id="WIGHVIM"/>
    <dbReference type="OrthoDB" id="410404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25577" checksum="0E1C5BBA0848E377" modified="2023-02-22" version="1">MVDAYGRAGLVINTKKPEVLQQLSTLNASLHNFHVGNTELAEVDQFTYLGSVLNNSHDLTDDIQRRVRLASAAFGRLSRRVFLNKNLSIKPKVAIYNAVCISRLLYGCKAWVLYRRHAKMLERFHISFLQRILGLRWWNKVPHAEIRRRAESPTLEATVAGRQLRWIGHVIMQRRRRAEFKPIDSKHWPKTEPSGDADAMTVLPAWTPSWSEQRRSSAPAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A798</accession>
    <name>A0A914A798_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059329.1">
        <property type="nucleotide sequence ID" value="XM_038203401.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059330.1">
        <property type="nucleotide sequence ID" value="XM_038203402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A798"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203401.1">
        <property type="protein sequence ID" value="XP_038059329.1"/>
        <property type="gene ID" value="LOC119730475"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203402.1">
        <property type="protein sequence ID" value="XP_038059330.1"/>
        <property type="gene ID" value="LOC119730475"/>
    </dbReference>
    <dbReference type="GeneID" id="119730475"/>
    <dbReference type="OMA" id="WEYLDLF"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="15">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="501" mass="59286" checksum="80148070E497EA09" modified="2023-02-22" version="1">MPPKKKGKKSGKKGKLAKMTEEERILYLEQKMLAEEEMKKKKEDMLNQFLKDKLVKEEKNTRFNMYKITHQWRNIMRAAKSKELKRDIEILSQTFERVVDRKDSVIKSLAKDLSEAEEQYSMALRSHLQNMDALIDLQRNRLAILKSEYDGEQSILMKEFNSERSLIIEQHRREVNDLQDILFAMEQNSNDRENEAKQEFQSLRDEIKNKNLEEKHALRIQLEGQVEDLWKQFQQALKSYNETTEERKAHFETLKSKDEKSAKEIEMQMRKLQRISDTIAQLKGKMAQNSRDSEERNKDLREQREVIAEHFHELKNQMNRFRDNERSRLTKLTLESNAAIKELKRKTDQGDRIVKLAEQCRKMETEEEKVLPFYASSLTQEEQEDVQAAVAEPPSEPLAEIMHEYVSLENFWKRYNKVLLDKVALDKERSTLLEENRQLRTVLKQYLDGISVNDEILSQVNPLFVVNQRTNVQLSVPVMDPRIKRPTQTVVEAAHIIKHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8F5</accession>
    <name>A0A914A8F5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kielin/chordin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060048.1">
        <property type="nucleotide sequence ID" value="XM_038204120.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204120.1">
        <property type="protein sequence ID" value="XP_038060048.1"/>
        <property type="gene ID" value="LOC119731107"/>
    </dbReference>
    <dbReference type="GeneID" id="119731107"/>
    <dbReference type="OMA" id="IDKCNQC"/>
    <dbReference type="OrthoDB" id="6412374at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="4">
        <location>
            <begin position="1495"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1612" mass="175820" checksum="13F6C5D84AC4ABF1" modified="2023-02-22" version="1">MTELLLLFNHNSVFRNFQNTVFLLESRQVRSETMKTLFLLVVLGVASSSNGQFEIPEPEEEWAGPVPPCQLEVNAAEPWDVLPDCDESGFHVPKQCNADRTLCWCVSRCGDPFMETKGGPDIVCEPDDPPCTKELASATGTGMRFGKFKPRCHANGFYHHTQCRGSVCWCTDRCGNQIPSSKHSIGTRGVCECPNDDYAWKCTTNPCDLETTRCPAHPDAVCKPSMCGGCVAKFYVEDKEVECALPDPETLQSQCTDYNGNKHEPDERWKMDKCTQCECMDGEAVCMSPSCAGPPMRWEYCLVKPGMEDVCCPDFDCIGCLDSDGRTHYDVGETWSEGGPSSCNLCTCNDNNNVSCVRELCPGVNRYIPPLCRWVIRTGECCPRDDSQNGIVCDEPISACEPGSVVMQDCPSDLCLTATCDGHPDATCKISHCGTCHTVFYDGDGAKVACQNEAVVMEALCSGSMTTCIVSPCDAGAVCRDYPEAACHVELCNQCDPLFFNERNEPLVCGEIREMCDETHAVGDHWEETCMTCECHQSALIACIPHECGLAPPLPVRCRWAKRTPDECCPSKMVCEEPLSDCPFSASVASSCPDDLCDTTCEGHPNATCLISRCGGCSAKFFDQNNQTVQCEGGTLQVEPKCPTDVPVLTCFASPCDVKTCDHYRFPDAVCHVDYCQPCTAVFHCPCNNLLDCEEKGKKDTIECKDSSNNKHDLGETWLEGCNECTCEETGIPTCRAKTCDAALNLATCEGGHRVGEIWEGSCMTCECSPSLTPVCIPHECGRAPPIPDRCYLAKQTPDECCPSKVVCEEALSLCREGTAVAPSCPDDLCDATCEGHPDATCLISRCGGCEARYFDESGQRVPCGQGLIVSQPVCPEDTPPVTCLIVFCELHPCVNYPDAVCHIDYCRPCEIVYYDELNQKIDCSVETKVDEIECKDSSNNKHDEGETWMEGCNECTCEATGIPSCRAKTCDTATCEGGQRVGEMWEESCMTCECAPSLTPVCIAHECGLAPPIPDRCHLAKQTPDECCPSKVVCEEALSLCREGTAVAPSCPDDLCDATCEGHPDATCLISRCGGCEARYFDESGQRVPCGQGLIVIQPVCPEDTPPVTCLIVFCEQSPCENYPDAVCHIDYCRPCEIVYYDELNQKIDCSVQTKVDEIECKDSSNNKHDEGETWMEGCNECTCEATGIPVCRAKTCDTATCEGGHRVGEMWEGSCMTCECSPSLTPVCIPHECGLAPPIPDRCHLAKQTPDECCPSKVVCEEALSLCREGTAVAPSCPDDLCDATCEGHPDATCLISRCGGCEARYFDESGQRVRCGQGLIVSQPVCPEDTPPVTCLIVFCEQSPCENYPDAVCHIDYCQPCKIVYYDELNQKIDCSVETKLDKIECKDSSNNKHDEGETWMEGCNECTCEATGIPACRAKTCDTDPMPQCNPDEYQESPRGVQTLHRCLKNGQFSPKQCDTSGHCWCANPDGSVATEQFDVPTGKELVCVSEPPCHRELLNNKHKTERGEVVTSDPVCSSTGWYEPAQCSPATGECWCSERDGTVVIGSIRRQGEPLDCNAQCLGDASNIVASIVCSKQYNGCPSDAFCHIPPNHTKGKCCYLPSRAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9A2</accession>
    <name>A0A914A9A2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paladin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060008.1">
        <property type="nucleotide sequence ID" value="XM_038204080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038060009.1">
        <property type="nucleotide sequence ID" value="XM_038204081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9A2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204080.1">
        <property type="protein sequence ID" value="XP_038060008.1"/>
        <property type="gene ID" value="LOC119731070"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038204081.1">
        <property type="protein sequence ID" value="XP_038060009.1"/>
        <property type="gene ID" value="LOC119731070"/>
    </dbReference>
    <dbReference type="GeneID" id="119731070"/>
    <dbReference type="CTD" id="27143"/>
    <dbReference type="OMA" id="WLCTHPE"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="100236" checksum="C4838C56B895EA6B" modified="2023-02-22" version="1">MGTGASSASSRSPSPEMMRNNRKNSFGIEGGGKWKGHNVVCNEVAPIIITKDCFEEFQCTLLAEKQEVTMGSIRDGLPEHVLVQGKYFMVADQFKGIDKMKTTEKHGAPNFRRAGGGFAVFGMGQPTGLGLAKVMDTLGQEGCSELIVCCIREEPVLFLKKNEDFVSYTPRAREKLCENIYTRLATSLDISNNEVAMRKEILRNALRNEENEFWFYEDIDQFVDEPHKYYIVYEEHLKTIQEMYAIHTVSQTNARYLRMPMRSNGAPDEQVIDTFFNVLKDVPTLFDHQDTSTPGLVFVGHMGASRTTFAMVLGMLVLGHKHGFPEEAYEDTKPFSQENPNLEKAEFPVVQQLCRALPDGIQVKQEVDVLINLSDEMSNIRRDIYESKKKMEAIKEDYEIAGGSAKQFFLQRMFKYLERYCFLLLFNSYLHQQKIQMFCQSFEVWMQQHPILYRILGDMDSFEKDNTPGMHLAMGNRFLVADEYLGLDVLSSHREVKVANFRRVPGLPVFGMAQPCREGLSKVVQYLTKEKYTHSSVHIFTLRGEMVLECDGATYTPRKLKSLTRNVFIPGITVEELEDRERQLKNEFLKLNGPVQVYEDITDPRITKEFSTIVTLQEMFENQCKITPELHYHRVAAMEYEGSPPEREFDFLVNVIKDLKDIYTDEDGPALVFNCDCGKERTTVFMAAAGLVIWHQKGFPVGVKLEEQERISVPQAEYTKGEFAVVMNLVRRLPSGPQVKREVDLMLDKCSETMTPMHYHQRETIFSTYNKIKLAKDEETAAKLGNQSFNFLERYIYLILFNSYLHIERPNNWTSKFATWMIETGRKIGAYETLDNLHYHDLDEDDARIVSCIRHRWVNKGNKLGYQGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9G5</accession>
    <name>A0A914A9G5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060064.1">
        <property type="nucleotide sequence ID" value="XM_038204136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9G5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204136.1">
        <property type="protein sequence ID" value="XP_038060064.1"/>
        <property type="gene ID" value="LOC119731117"/>
    </dbReference>
    <dbReference type="GeneID" id="119731117"/>
    <dbReference type="OMA" id="VANICTV"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038035624" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="230" mass="25087" checksum="6812B4AFBD8D66CF" modified="2023-02-22" version="1">MIKMKCLLIALFAVVVQCCLFAATAHADSDCDSCLEAALRPLYSQLDVFRDQLDAVHVSCTKDVLDCSEVGPLGMEDGRIPDASITASTFFYNLANYAPHRARLNFQGGISSAWASAGSSDPNPWIQVDFGTSVIVTGVITQGRGDSPYDNQLVSEFKVAYSNDGQEWTYVTAEGATSPRKFPGNLEGHNSQVTTTFPKAFQAKFLRILPTKWGAHCSMRFEVLGCESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA32</accession>
    <name>A0A914AA32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060712.1">
        <property type="nucleotide sequence ID" value="XM_038204784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204784.1">
        <property type="protein sequence ID" value="XP_038060712.1"/>
        <property type="gene ID" value="LOC119731590"/>
    </dbReference>
    <dbReference type="GeneID" id="119731590"/>
    <dbReference type="OMA" id="MYADWIK"/>
    <dbReference type="OrthoDB" id="2019266at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="81"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="236" mass="27184" checksum="DFFCE59020588720" modified="2023-02-22" version="1">MTDGDLQRIEGELEKRRTFCRRRVHEAVSTEDLKALLQEMYADWIKNDGYEKDMEVLGFTAHIELAETVSHFIPDRTSRLLDCASGTGLLGQELKKRGFLRIDALDASKESLDYSREKQVYTDYLCEYLGPNRLAIDDDTYDGICMCAAMGKAHVRPDCFPELVRITKPGGYIIFNVRGENLTIDDVLKNGRLDDVIHKMAAKGKFEYLEKKRQMYMQCKCNGKTEYCYAFVLRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAN4</accession>
    <name>A0A914AAN4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060823.1">
        <property type="nucleotide sequence ID" value="XM_038204895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204895.1">
        <property type="protein sequence ID" value="XP_038060823.1"/>
        <property type="gene ID" value="LOC119731686"/>
    </dbReference>
    <dbReference type="GeneID" id="119731686"/>
    <dbReference type="OMA" id="PPTAEMK"/>
    <dbReference type="OrthoDB" id="10027414at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="26120" checksum="FF019AA3D642DD5B" modified="2023-02-22" version="1">MAISEKLKKGSTSDFPSGFDRWLALQSVSDKIVRRASTLNAMEKLRLERATKQIDFKIQLRENHYDNVNQRLKETLKDHDLYKRALLRNAPPPRENNQVPPTAEMKPFGRYQGAYHSKMGTAMQREEEEIAQRKLRRRNKLLERAKHESETRIDPKLSTEQILSNNDKPLSERFKRTTTMRIATLRAQTNAVNAFMKVKRDAAVKKQAKRYSKSSLFKGVFQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAY7</accession>
    <name>A0A914AAY7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038061027.1">
        <property type="nucleotide sequence ID" value="XM_038205099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAY7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205099.1">
        <property type="protein sequence ID" value="XP_038061027.1"/>
        <property type="gene ID" value="LOC119731826"/>
    </dbReference>
    <dbReference type="GeneID" id="119731826"/>
    <dbReference type="OMA" id="MQANWSK"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="37171" checksum="F8384EDC5D8AA406" modified="2023-02-22" version="1">MAHSALHYTDNFPYENYEVLASSNRSVWDPEGSYEFEKFEMREVDASLMWFQNNWTKSIVYSALYAVLIYFGRIYMESRPRFNLRLCLVIWSFSLAVFSWIGAIRVWVYTIDFVRTYGWKASVCDPTLYKGVVGFWSWLFVLSKLPELGDTVFIVLRKQKLIFLHWYHHITVLIYSWYTYPQLVAPSRYFVLMNFSVHSLMYTYYALKASKWVSIPSWVNIVITSLQIAQMFVGCFVNGYAYSIRNNGGFCATTDANLRASFLMYLSYFALFVHFFVETYVSSKRRQRDPLAEKTQAQKSLQDSNENMKTEKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACK2</accession>
    <name>A0A914ACK2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061074.1">
        <property type="nucleotide sequence ID" value="XM_038205146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205146.1">
        <property type="protein sequence ID" value="XP_038061074.1"/>
        <property type="gene ID" value="LOC119731863"/>
    </dbReference>
    <dbReference type="GeneID" id="119731863"/>
    <dbReference type="OMA" id="RTPNLCE"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="19214" checksum="B53C29C32450EE11" modified="2023-02-22" version="1">MAKLWFTQPNPSRASPNPSRASPNPSRASPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPSRGSPNPWFTQPKPWFTQPKPWFTQPKPSFTQPKPWLTQRKPNKGITLYNGCYTSCRSINGHPIYQTPSTGFDRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACP3</accession>
    <name>A0A914ACP3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061119.1">
        <property type="nucleotide sequence ID" value="XM_038205191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACP3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205191.1">
        <property type="protein sequence ID" value="XP_038061119.1"/>
        <property type="gene ID" value="LOC119731904"/>
    </dbReference>
    <dbReference type="GeneID" id="119731904"/>
    <dbReference type="OMA" id="MATIDNE"/>
    <dbReference type="OrthoDB" id="10071925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="528" mass="58130" checksum="D900AFD2CAF3C2CE" modified="2023-02-22" version="1">MAETETAATPDTTQEIADPTKNKVEETNNNSEEMPQAAEKPAEDEPAASEEEKPKEEKSGEEDSPPSQEAEASEPASEQNIPQTDGGGEEATPGETDAKEADDSPDAASEEAAAKQEEPKQDEESAREDAAKDEAKEEEAVKGEDAETKQEDIGVEEMPKEEKELGESEPEKVMEEGGTGKSSELVEADAAPGGENRVDDEAPAEDAKAPAEDAEAPVEDAKVPEVVAEAPEIDAEADQKPDESTSEKVPEAEAADMHEQPTDNANSNNDDKQEDRATPIGESNEENKQQTSGETEEATPVLQQDAMPEEGEQTISEAPPTNEKPSSPAPQEQEPNQETPEEAQVSATTEPDKEELTDYELKYRASQKDIEDLRSMNVEIQQRLTKSEEEAKDRKRRGSEKDGMKVQADYMARELSQQQDTEKFLREKLAEVLEEKEESERKCKDLQLRLKRFAKDDQAKDERMTKMESELREISREVQVMEDHLDQETLRKIKAGKGGQSTNGEATTTRTQAKQTTPVPKSKTCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACX2</accession>
    <name>A0A914ACX2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061770.1">
        <property type="nucleotide sequence ID" value="XM_038205842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACX2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205842.1">
        <property type="protein sequence ID" value="XP_038061770.1"/>
        <property type="gene ID" value="LOC119732380"/>
    </dbReference>
    <dbReference type="GeneID" id="119732380"/>
    <dbReference type="OrthoDB" id="10641031at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="138" mass="16896" checksum="BB3A52E448E4D46C" modified="2023-02-22" version="1">MRQHTNGKMVLESIGGLISAGVFIYENGLLRFQSATLQETAYGLLVEKQQRKLHETYTIYLEQRYLGFINEKERKTFSQKRRVEWFSRERKTFSQKRRVEWFSRERKTFSQKRSVEWFSRERKIFSQKRRAQWFSRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADL9</accession>
    <name>A0A914ADL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WD repeat and FYVE domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062030.1">
        <property type="nucleotide sequence ID" value="XM_038206102.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206102.1">
        <property type="protein sequence ID" value="XP_038062030.1"/>
        <property type="gene ID" value="LOC119732543"/>
    </dbReference>
    <dbReference type="GeneID" id="119732543"/>
    <dbReference type="CTD" id="23001"/>
    <dbReference type="OMA" id="GVCHLIE"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2277"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2431"/>
            <end position="2738"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2879"/>
            <end position="2920"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3306"/>
            <end position="3366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2232"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3026"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3039"/>
            <end position="3051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3131"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3165"/>
            <end position="3181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3377" mass="376869" checksum="77006F6CE7F40619" modified="2023-02-22" version="1">MQQVQELTPLEKVEMCFTVFCFLKDSSDKSRVLLDEFRSCQGYIFLADFVLKLESMGDQESVHSLRNLVLLISSLTQCGYSELRPNSAIYEAPFQVQGFTLPQPSGNGNSVRNLQAFQVLQTIFLKANTRSLCSVILEVITNIYNSDNANYFILEPQHTMSQFIDRATTKSAEIQLKIFELLEFVVFNLNFVPYKELSSVSLLIKAGSDVGCLIRAIKCLLRILRHSGVYKDVYREVGLLAVMVTCLHRYAASLKDNQPDNKEDICSVPEVDVPELDEELAFLVMDCLTLLLHDNNDNATVFREYGGARCSHNLGPYIQCRQHALAIVQQLILSKDGEDDMGTLLGLMNSTPASQLQLKTDILQSLLNVLRDSHRSRTVFRKVGGFVYVTTVLVAMEASLSDSLREPWDTAPKDQVFTLLHVVFQTLAAAMRQEPANAKFFASEIRYETLTEEIRRLGCFSDVTELLPQAHCPAVSNDGSSNTEPFHNLFDIGGNPDHISDGLRSSCLLLRCLYDTAIDAFSSKSAQTPINSPASSHHVHDAFTPLPTPPSSPGKPRSTVRRLSPRSAGASPPSASSPLSPSAPPPPNHPTIVHPGAVLALLDLLPSVQCERDRKLALRLQMHIADVIQDLVKSERNQQVMCENGLPQRLLHLASAALADEEHPLHSNLQHMLERLASQALEPKDLRDFLRLGSPLNCKPLDECPNPASQSGYLDIPVSAISNVNAGNPSATGPATIITPEQFSFPAVSPDMSDTNSATSELSGKCSCNLCTTQGSVVPLTRVKCLVSMTTPRDVRLNSTSVTPAFAEFDMSAEGYGCLYLPSIAPQSTPSQTVVSVGMATTGDSANISGVGTGERAFPPQTGLTYSVWFCVDRYCTLDTSTHPVRLLTIVRNAISTENHSTCLRISIEGPERKLVINTSEEPLSKADDRPDNDPSAVRVFCPELAQEGKWHHLGVVFNKAVLKNSSVSLYVDGTHIHSHKMPYIQTHLPGTTSSPTNLTSVYAYVGTLAPQKSLSRLLWRLGPTHLFEDPLAASTLCAIYLLGPTNVGSFQAPRQEEFSSVRVDLSALQIPEEKIVIGIHAHALSVLTISKIRKTFNKFDSKSVAKQLGLSTHENSTPIRIIHNSACHLSGSGRSFGAVLIGNIGVRTFCPKPVASTLENIGGSAPLLGLIAMSTDVEGLYAAVKALVCVVKNNSPAMAEMERTRGYQILAFLLKKKKHLLNSHILHLTFSLVGTIDSGRETTIIPHRTAFEDLLCDLEVWHNAPYDLQRSLYDHFYELLTDSSEADKNRKMMRQLRMVNRLLYMLHDPTLTHATIQSIANLISVMLQGGSSSADLLSVGQFLASTLPNLSADERMVTLDELQCLVSDTDSQKGSRDNESMSEDWTGTISPHNIHLRNVLMDVILKLLFTPNTHNASPSMCEEILKILGYDWLLLFLQSHVHATTVIMGLRILVTMLYSQSAISKFRDGTFGGGWLDKTEAVLQNRMGVVLGFNLGKGKKGLQNREINQETCHMPGFTVLQWLLPRHASVPGIYFLLMAMSLGQQVRELPENCQLDLNSMWQFIFGIPTNQPLSGRVATNICTDAILVILAQIRAMLNHTIDPDEDIPWIQEYPVTLIQFLLYLYHNVPEFKPVCMSAPFLCGLASTMFPYTANTEQDYIHVEEYVIVPSEDSSELSSPSEEIKYLPGLGIPVFGIKSPDRYSNQSGNLANHPGRRYVMDFLRVIVMDSLSLPAPSKTPPVLDLLLEASPVRASPAQTSEFQTEVLANLMERLVAGDVLLEKEGALAIAAGGSFNNLINNVFYLSSRVVDKLWQGVFNHKSKDVFEFVVQLINQAKRRGSHGIPWDTIYHCMNRTVLYQLSRPHNTVADQYSLLESLHQITENRNLLFGHSNSEQEFGICLCHLLFSLTDDLSAGGMCLHCQSTEVNRTTQWHVDPMYPGSHSEGDCQERESTHAQEGQLLVRKASRRVWDELIASKKQFVEEIFKVTLPNSNAGTKGAVSVDLKIARSSMGETASKVWNSYITAEKRNSVRDQQVSSRLSSKVSTSFQLLSSSRKSKRESASFKFNLPSIQEASMWTFTHISIARDLVELQFNQHLESQQHLQRYITDEWSQMEMELTRERGLWGPPCGSELDKWILDMTEGPCRMRKKMLRNDMFYVNYPHQQEYDTLENPSKGRKPISFDSRKFWLRQRGRSLLDRGEGPVTEPVIDTDILMEGVEEEAGTREGLCPSSLVTKQGNSRLDKEWEDSETPDIETPVDKPEETKTDNQMILRLMEEGEKIRHMFRCARIQGLDTSEGLLLFCKEHFYVVDGFTLLSSREICDIDAVPAQHQDPIIPRASRGQRTYQKRTCSKFAYEDIREVHKRRYLLQPSAIEVFSADGRNYLLAFPRKVKNKVYARFVAEAPRLTDDTTSVAGQKRNVQVEGGSSFLGLGNLIGETTVTQRWERGEISNFKYLMALNTIAGRSYNDLMQYPVFPWILADYDSEELRLDKFSTFRDLSKPMGAQTEARLQQFRKRYDEWEDPTAFSPSLAGSVGEFQGETPPYYYGTHYSCAMIVASMMVRMEPFTKHFLRLQGGHFDLADRMFHSIKDAWLSASERNIADVKELTPEFFYLPELLTNHNNFDLGIKQNGVELGDIILPPWAKGDPREFIRMHREALECDFVSMHLHEWIDLIFGYKQQGKEAAEAHNVFHHLFYEGNVDIYSIDDPLKKNATIGFINNFGQIPKQLFKRPHPQKKVSNKIGDSSGNVIPIRRLFFNNLDTLRPSLQPLKELKGPVGQIIPSDRILLAVEQNKVLIPPVYNRFLAFGYADLSLRIGSYDSDKATTVFEGTQSGQILCAACPNTRMVITGGASTVVHVWQLEMRKERTKQLYLKQALYGHNDAVTCLAVSTAYNIIVSGSKDQTCLIWDLNRLMFVRQLRDLGAPVSAVAINNLTGDIATCAGAFLYLWSINGDPVASVNTSTGRDQRILCCAISELVEWNPLNVIMTGSSDGVVRMWSVEYVQVPDVSNSKRSSTSNIPQAVEALAPKVKDEDCTSESQSEDSQSVNSALIDDSEVSTPTKDSVDKVMSDSSPDDLSEGAPDYGTLKANRNSKISLEESRDYTSRPTPPSSLPVDGNYVDNQQGPGITLTQPGDLPTTTPDTLDSSSDQTSFTTADDMSDIINGNQGDDTDSISSRHLGNQGLRVENEVSPPSPMQRGEYVILSESDFDKYEDEYREREKMSASHRNKLKPGFKWQRQLVFRSKLTMHTAFERKDNAQPAAVTALAISRDHMKVFVGDERGRVFSWSVGDPQGKLMTDHWVKDESSDSCTACGTKFSLTERRHHCRSCGKLFCSKCSRFESAVPRLHINKPVRVCQACYNTLRLPKEPDSLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEQ4</accession>
    <name>A0A914AEQ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061839.1">
        <property type="nucleotide sequence ID" value="XM_038205911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205911.1">
        <property type="protein sequence ID" value="XP_038061839.1"/>
        <property type="gene ID" value="LOC119732413"/>
    </dbReference>
    <dbReference type="GeneID" id="119732413"/>
    <dbReference type="OMA" id="PQYMDII"/>
    <dbReference type="OrthoDB" id="9939609at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="234" mass="27157" checksum="433EDAC9F8EFF7B2" modified="2023-02-22" version="1">MAAHMALSRFAVVGKVWPQIIRLSTVGASQRQLSTTSSVFVKDAFRTTEQSWVKRIMRGSGPSQDIDDSLDEEEIVEVEPQYMDIIQTPKAAFIDKPQVRLRSYKPPEDLLDRLKDITLEVVPVATPENWTKLALKDNSIKYQILVNCFKTFNHDVPNFLLSKMHTMADVVTFYQTEVKDKTKFDELSTVDLPPNLKIHWNYSDDSRLELYEDYLEYIKPKKSPKPPEWKYRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGP8</accession>
    <name>A0A914AGP8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062696.1">
        <property type="nucleotide sequence ID" value="XM_038206768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206768.1">
        <property type="protein sequence ID" value="XP_038062696.1"/>
        <property type="gene ID" value="LOC119733184"/>
    </dbReference>
    <dbReference type="GeneID" id="119733184"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="450" mass="49752" checksum="6B536F66F6D147CA" modified="2023-02-22" version="1">MPGKRRAKRGGIRPREKMTTRKAKSSTVKSLEDEPTPGPTMRPKRPRRCKGEGISQQEKMTTRKAKSSTVKSLEDEPRPGPTMRPKRPRRCKGEGISQQEEMTTRKAKSSTVKSLEDEPRPGPTMRPKRSRRCKGEGISQQEEMAEPSAQETITEESSAPGPSKPGSRRGKRGGSKIRQQVSSQGGHWELAREIKKPKTLAHSDVAIRHNDILVLRHYKKGIEMYNPDDKQESPMKFHRGPRIEIAFDDIHNRLVVLNCHCLPAPEVKVFNSDNTLAYQFTTVPIGVHSPPSAATVAIKKDGTILVGFNITHLYNEHRPSDGKLLRTIPTNIIPHRLAADSKGRVFISCGSHGSVEVTDGNGVTLFTITPRIDGQSGLGCGGVVSDSSGIYVGACSRVNMYTAHIHHYDLDGRFLDCVAQGLYNPTRIAFTADGQMAVADQNSIKIYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGW2</accession>
    <name>A0A914AGW2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063225.1">
        <property type="nucleotide sequence ID" value="XM_038207297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGW2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207297.1">
        <property type="protein sequence ID" value="XP_038063225.1"/>
        <property type="gene ID" value="LOC119733936"/>
    </dbReference>
    <dbReference type="GeneID" id="119733936"/>
    <dbReference type="OMA" id="MRCQKCL"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18264" checksum="207CD25A66469F75" modified="2023-02-22" version="1">MATHMALLKASKNNQDKENVRCQKCLEFGHWTYECSGKRKYVQRTSRVSHLNKKIKLAKEQAEMQLVQVSRPKIDSKTAKTKSKRSKKHRKASSSSSSSDTDSSDDSDSSDSSDSSDTSSDSSVVSDSDSSDSSSTSSSNSDSDSSSSSSSDSDSRKKISRKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHG6</accession>
    <name>A0A914AHG6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063167.1">
        <property type="nucleotide sequence ID" value="XM_038207239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207239.1">
        <property type="protein sequence ID" value="XP_038063167.1"/>
        <property type="gene ID" value="LOC119733874"/>
    </dbReference>
    <dbReference type="GeneID" id="119733874"/>
    <dbReference type="OMA" id="MEPRMAM"/>
    <dbReference type="OrthoDB" id="5964668at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF286">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30312" checksum="52738CDCD5F9A3EC" modified="2023-02-22" version="1">MSSINSSAVLSSTGIAAAGRLGDFIKWPAAADIQRFFFTIAGFPGIVGITDGTHIRITAPNAHEVQFVNRKNYHSINQGFVVDNKCNFTQLNAKWPGSTHDSRVLRESSLANVFERGQGENEEVYLLGDTGYPSKPWLLTPFLQPGNRPEARYNGAHSLVERTIGQWKRRFHCLHGEIRLSPERTCRVIAACAVLHNIAKQQGFPDIDEDDPMDDPPNPQPDQPAQLHDNGDLVRNHILLDLDTVQRRNEETNRVWRLAHGTQTDCQTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHQ3</accession>
    <name>A0A914AHQ3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063208.1">
        <property type="nucleotide sequence ID" value="XM_038207280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHQ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207280.1">
        <property type="protein sequence ID" value="XP_038063208.1"/>
        <property type="gene ID" value="LOC119733918"/>
    </dbReference>
    <dbReference type="GeneID" id="119733918"/>
    <dbReference type="OMA" id="CASHREE"/>
    <dbReference type="OrthoDB" id="5979826at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="597"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="923" mass="104514" checksum="164555573F8CF71D" modified="2023-02-22" version="1">MQQYGDLFSGIGKIKDVKISLHIDPDVKPKQQKHRRIPFHTRKDVERELRRLEDADIIERIDGPTPWVSPILVVPKPSGEIRICVDMREANRAVQRERHPMPTLDDIITDLNGCTVFSTLDMTAGYHQFELEEECRNITTFSTHVGLFRYKRLMFGINAASEIFQSAVAQLLTGLSGCRNVSDDILVYGKDQQEHDRNLKAVLDRLQSHNARLNKSKCKFAQPEVKFYGHTFSGDGIAPDPKKIEALINATAPKNAKEVKSFLGLASYVSRFIPNYATVTNPLRALTHQDSKWKWEQEEISSFNELKSILTNTNVMVYFDPRKPTDIIVDASPVGLGAMLSQDGKIVSYASRTLSDVESRYSQTEREMLGVVWAVERFHLYVFGAHFRIITDHKPLLGIFKSSRPTSARIDRWRLRTMSYDCDIVYKPGKDDENPADFISRHPGSQAPNKSVAEDYINYICNNAVPKALTLEDVRAETAKDGIMQKLMTTIQSGKSHDWDDVDMRPYKPVRSELTICNGAILRGNRLTIPASLQPTIIELAHASHQGIVKTKSLIREKVWFPGIDRMVEDKVKQCLPCQAATTNSAERPEPLKMTPLPSAPWKEVAVDFTGPYASGEYLLVVVDEYSRFPEVEIVSSTSARATIPKLNAIFARQGIPDIVKTDNGPPFHGHEFAKFASYLGFTHRRVTPLWPRANGEVERLNRTLGKVIRIAETEGVSWKQQLHRFLRQYRATPHSSTNLSPSEALNSRKLKCELPEIQSPKRPYSRDDSLQERDAQQKSKMKTLADTRLFAKPSNIQTGDVVLVRQPKQSKHTSPFNPKPFQVTMRRGNMVEATRGDKVTRRNVSHFKKVQTPPPDPHTLEDDNSDDPTDDIPLVTDSQPSQDPQSLVKSPAVLEDSPKLKSSLRQSTRVRKPPVRFKDYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIB1</accession>
    <name>A0A914AIB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063388.1">
        <property type="nucleotide sequence ID" value="XM_038207460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207460.1">
        <property type="protein sequence ID" value="XP_038063388.1"/>
        <property type="gene ID" value="LOC119734092"/>
    </dbReference>
    <dbReference type="GeneID" id="119734092"/>
    <dbReference type="OMA" id="ERLYEPY"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="742" mass="81526" checksum="56FC8396AE8D5A1F" modified="2023-02-22" version="1">MHAAMKLDMRVNRVLLPFKAVYFFFLAGMSCLIPFLPIYMHQLGLTITETGLIRSLEPAISFIASPVWGSLADKRSKHKLLLIVSLLGSSLLTFALIFVPSSDTPDAHDVSDNYTTNQELCPSWNWLLNCSEPEWAGSSLCNRSDSGNRRTDVCSEVCDTAASNRDLPMRVGSDVYLNCTLCTSSEMGTAIPPSKPNATVQSTSITWTYQPPMHSSFLRVFCLQLQENSSDLSRKVSKCPNKTSDGDSRCASFSQNSSSSFQECLPWRHCACSNLTATEPREVSPPPHASNLYIFSLVIALILSSKIFVCNVFPLLDSTLMLTLGTRPQDYGKQRLWGSVGWGAFAVISGAAIDAFSRGSPRTNYVPAFYLFIVLQAGAFVSSFFFNSPPHVPNKKILRNLCGLLLQANIVTFLLVVTVAGMSFGITGTYLFLFLEEIHSPHILMGLTLTVNCVSEVPFLFFAGRIIKRITYIGVAYLTLLCYAMRFLGYSLLGNAWLVLPFELLHGFTYGAFWAACTSFASANAPTGMTTTLQAVISAFHMGVGRGLGTALGGVVYQEWGSRTLFRVCLFTCLGTVVVYFLLRRFLVEGVEGPLAMYRKFSLIRGEPSSTDGARKDSCLSELDSDTCKAMDAQQMQLTVTTIDQSKPDSPPVTTTYHTHRPLLHKIPIPNTPDSPEDDNNANADSPSSISSMSRLLRMEERLPAAGQEVLEMRGEGRPPALGEESWPQQEFRGKGGKQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ93</accession>
    <name>A0A914AJ93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063708.1">
        <property type="nucleotide sequence ID" value="XM_038207780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063709.1">
        <property type="nucleotide sequence ID" value="XM_038207781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207780.1">
        <property type="protein sequence ID" value="XP_038063708.1"/>
        <property type="gene ID" value="LOC119734336"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207781.1">
        <property type="protein sequence ID" value="XP_038063709.1"/>
        <property type="gene ID" value="LOC119734336"/>
    </dbReference>
    <dbReference type="GeneID" id="119734336"/>
    <dbReference type="OMA" id="MARPFHY"/>
    <dbReference type="OrthoDB" id="10033658at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029134">
        <property type="entry name" value="DUF4647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130:SF1">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15504">
        <property type="entry name" value="DUF4647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117916" checksum="9E0E7B6A285DDA39" modified="2023-02-22" version="1">MSTVMAADNLLKQYQVEETSCGPLCQHPQCWASNRRIERGLPRLKDPLQTSWNASEDEGALPTLKVQNLLAESGFGATDDYPTTQLPKHQRSSSAPAVNFDNRPKHKFPYTPYTSPLGVRSTSAQTVPSSIAQGHQPAKARSVEVRELFEVDELNSDWQQTFVPSRVYVWCPSKKAYERQLQRERDPIPEPNEQNDVSKPVTLKDMTDKMVPEAPRDKTKGTKKMKKKPSRITPTGGRPYTHPSRSPPVHRQTKPVNMDDSIAELLTLPRDILMDVLVHIKNSDSLDKRKVQLLLSRLMPLIHFDTNQPLHRSLSPTPLLASGILQNKKMSLLQGGARRNQTEVGAAPGASASARHKHPFYLDDSLISAMTTSTYSALTQQLPMEEGVASDQEMGRFGRMAHQPPLGPISAGVSQKVAQVPQSAQVRNKLTSVSTKSLPPLVPGTKPTKPFDYKAAKSLDLTLGPLPTPDNLSPEKPSTPRSEKASTLYVTLPSVLSPDRTELTTPLQPYGRVSAPVYAERFASQYLHDTPSPIASEDFPELFWCDNEHPLHAVSPSLSTGVPQAPLGTPATNIHQAYKPLSASYHRPGRSPSPSKQTTGTLQKETTAQDPLNAEALGTIREVHSELPTSYPGTSAMDTSLPTSPVKYGMTPVSTPWGNCTSITAGGNSDAPSRSPVPPVTPQPSATPEPWPVVDERDFMTSPEKPREMAPGQEISMATPMAPPPSPEPQELKNEFEFAVNDMSKSGMTSLTPLVEEGEEEGEGNEEEAEEDWGKMMEATSRTEDIKEDALKNEDIKENVENKIDHEGAFENEDLMVDVGNKMDNMDNTESKDVREEVEESASNVNEGVVKNVDKGTFESEDINKEHQESDSEIKDIKQDSKIKIDQEVASPSEDIREDVEGKRDESERDAGADSPKPAFDDDEIPQSSLEVLSMSNNLNNSAVTAEDVVADEIVPDPSLTSGDLVMPSSLDNEMAKPPIEDELKLQVVQENPGGAEGYSGTAQVESAAPNETKQEHSDEEKSVPELPMTDLVLDVESKEITPEPQECTIENTVPTANHTADCVGQIEGPVSNMDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJH5</accession>
    <name>A0A914AJH5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063778.1">
        <property type="nucleotide sequence ID" value="XM_038207850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207850.1">
        <property type="protein sequence ID" value="XP_038063778.1"/>
        <property type="gene ID" value="LOC119734360"/>
    </dbReference>
    <dbReference type="GeneID" id="119734360"/>
    <dbReference type="OMA" id="GVEIWFE"/>
    <dbReference type="OrthoDB" id="10031677at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35015" checksum="CA3732EEBD9AD495" modified="2023-02-22" version="1">MSEPVRVIMWSVPRSRSSIVAKCMDGVPDSQIFFQVYSSAFWTGLGEFNSSDSSLQSEGFYRVQDEITNAGAQSKSFSKGEAKADYQWVKRQLEANYPGKRFLFAKEMAYCINGKFEYLPKGYRHIFLIREPVKVFQSLKKTVPEIVAVQGQQIPGMEGGDFELDKQPPHLIAPEYGFKELVNLYEYLQEANMEPDPIVVDSDDLVNDPARILSAVLERLGVQFQDSILNWEKGMDVMEEWVVSRGVKNRITKASSFKSFRDSTGFLQETAVPGTTHSTSANLTADVQHCVEFSMPYFMKLYEKRLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALA9</accession>
    <name>A0A914ALA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064785.1">
        <property type="nucleotide sequence ID" value="XM_038208857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208857.1">
        <property type="protein sequence ID" value="XP_038064785.1"/>
        <property type="gene ID" value="LOC119735154"/>
    </dbReference>
    <dbReference type="GeneID" id="119735154"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000010">
        <property type="entry name" value="Fli-1 proto-oncogene, ETS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="326" mass="36323" checksum="1E2A0A9E27F32DCB" modified="2023-02-22" version="1">MFESTYQHHHQEVPKTSSVSSAVSPHHHSSALQSAVQKPKLSPQSSPVVDHGNTLPSPQQQQQQQQQQQQQWAQCRQQEIIRMKQEPDHGSHGHEAGSLGGRVVEAESPLDCSVTKRQPHGAMTEATQAAPPYPCPPYPGSESDRARSPPPNVTTNEKRVIVPADPNMWTIDHVQQWVQWAVREYSLQDVLVSRFGIDGKQLCKMTREDFTRLTSSYNADVLLSHLNFLKQAPLPNLTSDDVDKALQPSPRAPPSSQATNIGTAQPITEKKYTCNATNYYPDQMQKASASAFPYPVSSHVDTNSRMQRTAFLFQDFNSNPSLQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALY6</accession>
    <name>A0A914ALY6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064598.1">
        <property type="nucleotide sequence ID" value="XM_038208670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208670.1">
        <property type="protein sequence ID" value="XP_038064598.1"/>
        <property type="gene ID" value="LOC119734999"/>
    </dbReference>
    <dbReference type="GeneID" id="119734999"/>
    <dbReference type="OrthoDB" id="6155977at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="102" mass="11020" checksum="0C50906955268D78" modified="2023-02-22" version="1">MFDRWGTLITVGTGICRGCLSKHKQAVTHQTAEQLPSDVRCKEQEEQQCTIRDFTSPAGVQALQPTDTACTSVHEHTSESSSTDGDITQDVGALDSSWAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM94</accession>
    <name>A0A914AM94_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Myosin heavy chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064641.1">
        <property type="nucleotide sequence ID" value="XM_038208713.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208713.1">
        <property type="protein sequence ID" value="XP_038064641.1"/>
        <property type="gene ID" value="LOC119735028"/>
    </dbReference>
    <dbReference type="GeneID" id="119735028"/>
    <dbReference type="OMA" id="NMEQCQN"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="78"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1260"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1306"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1911"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1260"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1314"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1919"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1946" mass="223792" checksum="0B21EAB1710BDB7D" modified="2023-02-22" version="1">MSDDPESFLSVSRKDQLEAAGTQFDTKKNCWVPDQKDGYIAAEVISTKGEQVTLKTVTGKQVTLKKDDTQQMNPPKFEKVEDMAGLTFLNEASVLHNLRSRYFSGLIYTYSGLFCVAINPYRRLPIYTDKVVMLYKGKRRNEMPPHVYSVADNAYHDMLQDHENQSMLITGESGAGKTENTKKVIQYFANIASSHAGKGGSEEGKKGNLEDQVIQANPPLEAFGNAKTIRNDNSSRFGKFIRIHFGTTGKLAGADIETYLLEKSRVIYQQPLERCYHIFYQLQSGQIAGLNEKLLLTGKPTDYRFSSQGKTEIDNVDDKEEMKITDDALNVLGFEEDEKLSLYQLTAGIMHFGNIKWKQRPREEQAEIESTDTADKVAYLLGVNSADLVKNLLRPRIKVGSEYVQQGRTKEQVAYSVGALCKAIYDRMFRSLVHRVNKTLDTKATKQYFIGVLDIAGFEIFEFNSFEQICINLTNEKLQQFFNHHMFVLEQEEYKREGIQWDFIDFGLDLQDTITLIEGPMGVFMVLEEECMFPKATDKTFLEKLIKNNADKPAVFGTPGVGSKKKSGAEYHFEIHHYAGTVGYNVDFWLDKNKDPLNEAVVELFRKSTMVLLHTLFAEIATAGGGRKKGGSFQTVSALHREQLNRLLATLMNTKPHFVRCIIPNENKKPGVIDARLVLHQLACNGVLEGIRICRKGFPNRMPFSDFKQRYMILAPSSVPQGFMDSRKACDLLLKSLDLEANEYRMGHTKVFFRAGVLGQLEDMRDTRLSRILSLLQAVCRGYLMRRIYKKILDQRVGLAVLQRNIRKYLVLRNWGWWRLYTKVKPLLNVARAEDEMKAMDEELQKAKDKALKEEKERKLLEDKNSELMKEKNDMFMQLQQEQDNAADIEEKLSKVMSQRVDMETQLAELQARLEDEEDSNADVSASKRKLETECGELKKDIEDLEITLAKVEDEKKAKDSQIKMLNEDLAAQDEVIAKLSKEKASLEETNQKTLEQLQAEEDKCNHLTKVKAKLESTVDELEDSLEHEKKARADVEKVKRKLEGDLKMTQETVEELEHAKREMEETIKKRDYDLSQLNSRLEDEQSLVAQLQKKIKELQARIEELEDELEAERQARAKAEKQRAELGRELDDLSDRLEEQGGATTAQIELNKKRESELIKMKRELDEAHMQHETSMASIRKKQQETVSELSENLDQLSRTKTKIDKDRQMLKAEVEDMNTNVEMLQRAKMNSDKTIHQLEAQLSELNGAMDERNRSISEMNSQKNRLTNENSELTRQLEESESNSGQMSKNRMQLLAQLEELKRQLDDESRSRQSLHQQLKQAQMDNDSLRDQVEEEAEGRADLARQLAKSNQELQAMKAKFDGEAVHRAEELEEQRKKLMVRLAQLEEQLSQALTKNGSLEKAKARLSGEVEDLMIDVERESNRANALEKKQRNFDQVLAEWKAKVDELSNELDAAQREARQYSTELFKIKNSYEEVIETVEIVRRENKTLQVEIVELTEQLGEGGKSVHELEKARKRLEMEKEELQAALEEAENALELEEGKVVRAQLDLAQTKNEIERRLNEKEEEFEATRKNHQRALESMQASLEAESRGKAEALRLKKKLEGEVNELEIQLDAANRQIADLQKQLKKYMADLKELHGNYEEEIRIRDDLRDQLQLTERRSNLLMAELEEQRASLEHSERSRRQAENDLADQSDRMTDLTAANHSLTSQRRKMEAEIQTMQGELDDLGSEARNADDRAKKAVSDATRMAEELRAEQDHSMHVQKMYKSVELTVKDMQSRLEEAEAMALKGGKTTIMKLEKKLHETERDLDAETRRRSDLDKAVRKQERRLKEIILNSEEERKTHDRLQELIDKLQIKCKNFKRQTEEAEEMANLNLNKFRGAQRELEDMEDRMEIAESTVNKLRAKHRSGVVGSGSTTRITTKTTSGSSSVMRSASSSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APT8</accession>
    <name>A0A914APT8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065772.1">
        <property type="nucleotide sequence ID" value="XM_038209844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209844.1">
        <property type="protein sequence ID" value="XP_038065772.1"/>
        <property type="gene ID" value="LOC119735898"/>
    </dbReference>
    <dbReference type="GeneID" id="119735898"/>
    <dbReference type="OMA" id="DAKCTHT"/>
    <dbReference type="OrthoDB" id="5809364at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="265"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="52867" checksum="A04A71ED3E250711" modified="2023-02-22" version="1">MGGSFSWLTRSDVMASGLVAPWWLLSSLLLTTAWSCIAHNASASHLTETRLRHLIVTGNGIYDMLVRPAITPNQSVVVDLELHMYALISMDEKAQVMTGASRLKLTWHDYRARWDPMDYDNITDLSLGLSEIWTPKILLSNGAGDRIENPVKESVFLALLKWDGTVELQGQVIHKTHCAMQLSEFPFDRQTCWLTFSSQNMPKDMITLRAGASSVYGLEITSQWRPLELYGVVPEYVIGSRTYQLLGLKFTAERLPHYTLMNVALPSGAMTFISLWVFWLPPESGEKVSMAVSILLGQAVFWLVVIESLPITGGQGTPILLSSIECNFLVAGLAILLSVVTVRVHHRPGPLRGRVLRMVFLRILPVVVCVTRAGTRKGKVDMSDSQTPTDAKCTHTVDEDAAQSVSTSTEDRFSDKVAELKSREDPQSCSKAIKDENDSEDMKLVAAVLDRFFFVIAAVLFIYGNLPLIIKWMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQL5</accession>
    <name>A0A914AQL5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066344.1">
        <property type="nucleotide sequence ID" value="XM_038210416.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066345.1">
        <property type="nucleotide sequence ID" value="XM_038210417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210416.1">
        <property type="protein sequence ID" value="XP_038066344.1"/>
        <property type="gene ID" value="LOC119736399"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210417.1">
        <property type="protein sequence ID" value="XP_038066345.1"/>
        <property type="gene ID" value="LOC119736399"/>
    </dbReference>
    <dbReference type="GeneID" id="119736399"/>
    <dbReference type="CTD" id="54919"/>
    <dbReference type="OMA" id="AFQGPWA"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000746">
        <property type="entry name" value="Dynein assembly factor 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001984">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="4">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="3">
        <location>
            <begin position="320"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="2">
        <location>
            <begin position="676"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="834" mass="94633" checksum="8E8991EDE33604E4" modified="2023-02-22" version="1">MAENVESVDARTTEILQAVTRHINCLSENNRATKKRALESIRRETLGKKPALDPEILQRVFDSLLKPLLKCFADSVERCRELAIDAVSEFLDAVPMPEGSLPYLMPTVVQRLGNQEIVETSEELRLSLVSLLVKLSELTKKKIAPYLDDLVKILQRTIVDPFPDVRRESCKCTSLVARSIPEHFHMQSESLITPLLHCISHQHAKVRTQCTLTIGDVLQYGSHKPMDKVISHLAQRLFDQSPQVRVAVTDVVGGWLLDFVDRYSFHHKLIPLLLTSQTDELPDIQQRAFKLWDDIGDKYAKENEEELKDQMDFGKYVKLPPGETKRPNLGCRTLIFRNLSKILPGLLHDLTDWTTSNRIMSAKLLRMLLLNAEDHTTQHMEKLLSGMYKACGDEEKEVVTQILQSAELVGFFVDPAIYWKLMSPTVQLAQSPGVLMTLAALIRGSTQEGFHPQLQSVCDVLVDPEVCRGEQHSYQIHLVSCIEAIMGTSKEQCSEVSLSLLMVLVTVLALERDDALKNKTRDVIESLAQVQGMESSSALYRQHSRQMLDLLKGNYEQWTNFSVERPIFDTLLTESGVLVIELLDDIFPVLQANLKTDKDPELRLKFFSLLSRLVMKAGESPEAKARFGDFSLVVVREMVIPNCVWHGGRTASAIRTTGISCLWALLQSGLLTAEQVSSVMDDLQTQLTSLLEDDSRSTRLITCRVFRKILALCGATFDPDRLHTMYMELLKRMDDSSDEIRVAVAKTFQTFFQCFPADYDRVLYRAHLETLYRGLLVHMDDPDPNIQQAVLDILKQAAPLHPKLLQEEVETVRHKHRSFLLCDELLQHIKTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASC3</accession>
    <name>A0A914ASC3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066266.1">
        <property type="nucleotide sequence ID" value="XM_038210338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210338.1">
        <property type="protein sequence ID" value="XP_038066266.1"/>
        <property type="gene ID" value="LOC119736295"/>
    </dbReference>
    <dbReference type="GeneID" id="119736295"/>
    <dbReference type="OMA" id="GHEQQSE"/>
    <dbReference type="OrthoDB" id="5961208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="299" mass="34047" checksum="A2EF48F63B05C03B" modified="2023-02-22" version="1">MAVNVEDALQYSMTGICTLAVIENLIAIAVFAGTQKLRIKYYTFVVNLALADLIFALFTIPYPWRPKPKILQGFFTGAYTVSLLTFPAVAVNRYLALSLMPPARYDSLVTGRRMIGVCILFWCLSFVYGLVIYNAVPKDVYYLVNFLGYSLAGCVVLAITALVYFLVFRKIKQYTPPLASAAGISANEERDRTRVKQTRRLLVMFVLILVVAFITWFPCFVLRMIAILNPSLGLDEIFQMWIWVSYLLYTLSPVINPWIYWWQLDGFREGFYAMFCRCIIKAEPSEIEADLKTVAETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASP5</accession>
    <name>A0A914ASP5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067080.1">
        <property type="nucleotide sequence ID" value="XM_038211152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASP5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211152.1">
        <property type="protein sequence ID" value="XP_038067080.1"/>
        <property type="gene ID" value="LOC119737072"/>
    </dbReference>
    <dbReference type="GeneID" id="119737072"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="516" mass="56284" checksum="3C1A80BD9BE002BC" modified="2023-02-22" version="1">MTEVREREGKKGEYTVEPVENGGAEPLGKKVPLDGDGVSVGDGKGVKLKRQVGLISGIALIVGTMIGSGIFVSPKGVLTQTDSVGMSLVVWLLCGVLATMGALCYAELGTIITKSGAEYAYLKYAFGDVIAFLFAWVSIAVIKTSSVAIIAISFGTYVVSAFFEGECSQPDVLIKVLAAVAIILIVFINCASVKWATAVQNFFTAAKLLALVIIIIVGFVKLIQGDVRYLTPSTSFQGSSTNVFAYGIAFYQGLWAYDGWNQLNYITEELVKPHRNLPLAIIIGIPLVTVLYLLVNIAYFTAMSPDELLQSGAVAVTFANRTLGVMAWLMPVAVAFSTFGAANGTCFTAGRLTFVAAREGHMVEILSMVHVKRYTPFPALVFQSFIAILMLLPGDFESLVNYFSFAAWLFYGGTVAALLVLRYKHPEWHRPIKVPILIPIIVLIASVYLVIAPIIDEPALEYLFAFLFILAGLIFYVPFVHYKYVPPFMKHITVFFQLLLEVAPTSYFEPEEDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ATT3</accession>
    <name>A0A914ATT3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067182.1">
        <property type="nucleotide sequence ID" value="XM_038211254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ATT3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211254.1">
        <property type="protein sequence ID" value="XP_038067182.1"/>
        <property type="gene ID" value="LOC119737138"/>
    </dbReference>
    <dbReference type="GeneID" id="119737138"/>
    <dbReference type="OMA" id="LTICAFV"/>
    <dbReference type="OrthoDB" id="10428862at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF120">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="44"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="416" mass="45819" checksum="98793985F0707B53" modified="2023-02-22" version="1">MENTTFDDVVFNLSTTPSPIEPPVAGSILVGILLLLLVIVTLAGNIMTISAFISNVLLKQKPSNLLLLSLSCCDLVVGATGLPVAAIHTGLGYWPLGKAACVTFAFFSVVGVSAGMYTVTAVSLDRYFLVSREYPAYLKLQSSRNVKLTIAAAWTVALLIGSCEAILWLVGDYSSVDYSRECLSPVRSDPRFILVIFILLFVIPFFVILVSTLRFSMLLRRRLRKRKGPRRRSVDVVNNRLVHPKDADKDPPTVASSTLMSSESPSEMETTEFSSTPNSHQQPPLSPGGAVEPRRPLKRKTMDASWRKKSFFGLGDGSLGGAGSFSRAKVRRRYVKPAVRLAILLGAFALCTLPYPIFIVLSKGSDCDDCISRQVRNHLSNLLLSNSGLNPFLYAVMHRKIREYFKMKLTCNRKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU11</accession>
    <name>A0A914AU11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4795 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067163.1">
        <property type="nucleotide sequence ID" value="XM_038211235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211235.1">
        <property type="protein sequence ID" value="XP_038067163.1"/>
        <property type="gene ID" value="LOC119737130"/>
    </dbReference>
    <dbReference type="GeneID" id="119737130"/>
    <dbReference type="OMA" id="KQELIWQ"/>
    <dbReference type="OrthoDB" id="5981048at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032013">
        <property type="entry name" value="DUF4795"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47080">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47080:SF2">
        <property type="entry name" value="GLUTAMINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16043">
        <property type="entry name" value="DUF4795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4795" evidence="3">
        <location>
            <begin position="521"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="861"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="990" mass="110149" checksum="8C3F61D045479E60" modified="2023-02-22" version="1">MAGSVSLLELVDLSLGTPEIVNYKGLRTLLVAIVENLKLGDVRAELKESDRAELLASAAAAAAPAARPGSSDIGKGGVEKSKSDLSRVHSAASSTNKEVQDLEHKVSRLESQIEALNSLPSNENLMQRARSTEGMKPMSEMWQLMQLQKKASANEDGVSKLMSMVEDLLGEMSALREHVDGFSSEIANLKDRLNKISANEERFNERLQKLENSTANKDKMDELQKIINDLNNKMNTLPPLDIIVTWPAMEDALKGIHREPISVYDHAMQTMAMTDTSNVQTMPTKSSYSQTRTPSPGPPSNPPSRPGSAAHPSMEIQRILKDIGELKGKHDSVENRVKTLEELMNSKLDLDDVKKLLGEKKDVPEDLTRMLEELKEGLDSLKEGRDKMDQLDRWISEQSQMVPASQRDVQQLRDELAQTQADLAADIVAMAKNLPVGSTVSTARFDSMHSQFQDQLEGHSQGLSQELGKQLGKVTSRLGHLEWRLDSQGKQLEAQASMGMLDSAHRLHEVEQTQGSGGDLDSEVITNMQKLILQLQAEVDKLNHTCVQLVDEHNSKQKHIDALYTFVDRLQENKADKEHVIMEIDVKADKRALENKVSTTHFQGTVDELSRNLNDVLDKLSGHRSAWQEAVSEMKLDIDNKLDRMELDPLKSYLDNRIKSVGAKLVRKVEVDTTQDDAAGFRKQLMQKFNCISCDRPLDMTPQPPLASLPESKGMPGTRTGRPYTTFELEQIRAAQKKAKPGRNVLHYDKALQEQELARQRKQDIMAYLVHFHGETDRPAFIRNVPQLHLQPDRHSGNVDVPDYFSTTRSCGGSHTMTYPHRRNTRMANLTGIVQEEDAVSVNNFVNGSRLEADIQGQDGHIYKGRIGPTDLERLPTIAPHRLPSARSPRPTSSRANRHDNQLSKSTPERQASRPTSARPQSRLQQTRPTSARPQSGRSQGSPTPPQSLNPAEADPRPTTPPNTVEVTAGQDDSSQNVIAEPAEQPIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU32</accession>
    <name>A0A914AU32_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">APCDD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038067570.1">
        <property type="nucleotide sequence ID" value="XM_038211642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU32"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211642.1">
        <property type="protein sequence ID" value="XP_038067570.1"/>
        <property type="gene ID" value="LOC119737350"/>
    </dbReference>
    <dbReference type="GeneID" id="119737350"/>
    <dbReference type="OMA" id="MPLIQCT"/>
    <dbReference type="OrthoDB" id="5985602at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042425">
        <property type="entry name" value="APCDD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029405">
        <property type="entry name" value="APCDD1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021">
        <property type="entry name" value="ADENOMATOSIS POLYPOSIS COLI DOWN-REGULATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_56, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14921">
        <property type="entry name" value="APCDDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01352">
        <property type="entry name" value="APCDDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037271773" description="APCDD1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="APCDD1" evidence="7">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="APCDD1" evidence="7">
        <location>
            <begin position="279"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="501" mass="57643" checksum="5CA9A86A94743057" modified="2023-02-22" version="1">MEVQSLGLVITVSFLVLCGLASAVPSGNQLDSHIVRALSESECGAQMRRLQGNEGVSAIVPPRPKGEWVSMRCEVRPGPEFILRRYKFHSDSSFSLHQFFYTDDQCRHPAYSLKIRGTIALGQQSWVVSGATEAEYHVSKVTMVVYDETFGRTLRSQVNRTCPGFFSSSNDVLELYQRYVIVDWEQESTFTECTEAMDFAMHELQIVRQEFHSEFNTGIAKFVSWEELFLGDIHTDRKQRMYYRPRAYQPPLRKYQANCSFCQLIHNTEEFNPPLLPARTEYQVSLRSEWVSTRCEVRKIHFVIRHLVFHNNYTWEGYFFYFRDPMCQHPVYSIYVKGAHSDGTMSEIVTGGTEFEFVTSQMWVTPKNSEEVVKFNKNDDDCGAAGSWRLNQPQEVTGTGGCSVIGITLPHTESELMRMEQGRDGKALLFNRERPTDGDLSLEKPTSYQSPLRHCAGVNPLIDITVTYENNEENSGTRLRTCYALQTLVWCLWICIYLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU61</accession>
    <name>A0A914AU61_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067297.1">
        <property type="nucleotide sequence ID" value="XM_038211369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211369.1">
        <property type="protein sequence ID" value="XP_038067297.1"/>
        <property type="gene ID" value="LOC119737193"/>
    </dbReference>
    <dbReference type="GeneID" id="119737193"/>
    <dbReference type="OrthoDB" id="10119857at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037895297" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18644" checksum="6B8EDD5752980478" modified="2023-02-22" version="1">MFPVLILCLMLVSRVEGTWGTKNRDPSDGVMGFSYINMTCNEAGDVCQNCLVTRLFGQVFLAVQEYTKEPYKFEAKVSEGRQSRDWFFSQDEPEEKYRWCDSFDSEASWEYDKPWGYTYCIENIFSGIAVPAGCAKPLAVLTYDIHYSDEELHGEQVLFCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVY2</accession>
    <name>A0A914AVY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-245 light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome b(558) alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b558 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neutrophil cytochrome b 22 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Superoxide-generating NADPH oxidase light chain subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">p22 phagocyte B-cytochrome</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p22-phox</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Component of the phagocyte NADPH oxidase core complex/cytochrome b558 complex, composed of CYBB (heavy chain (beta)) and CYBA (light chain (alpha)). Component of the phagocyte NADPH oxidase complex composed of an obligatory core heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic regulatory subunits NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A. Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX4; this interaction mediates superoxide generation. Interacts with calprotectin (S100A8/9). Interacts with GBP7. Interacts with NOXO1. Forms a heterodimer with NOX3 and is essential for activity and cell membrane localization of NOX3. Interacts with NOX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p22phox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067853.1">
        <property type="nucleotide sequence ID" value="XM_038211925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211925.1">
        <property type="protein sequence ID" value="XP_038067853.1"/>
        <property type="gene ID" value="LOC119737509"/>
    </dbReference>
    <dbReference type="GeneID" id="119737509"/>
    <dbReference type="OMA" id="ARTGQYC"/>
    <dbReference type="OrthoDB" id="2445232at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007732">
        <property type="entry name" value="Cyt_b558_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168:SF0">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05038">
        <property type="entry name" value="Cytochrom_B558a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="180" mass="19645" checksum="05F0ADC33B595CB1" modified="2023-02-22" version="1">MADMKSEWAMWANEHGFVSGIVMLMGGITGVFGFDGYEFAAYTIAAGAFITLLEYPRSQRRKGSLVARRFQHILHPIMNLGGPITKNYYIRFVLYLLMSVPSIFTLPTVLGGASLFIAGLIYFKAALGGEGWHVDSMALARQKTLTNRPPANPPPRPPPQGAAKPDDNFTEIPLGNVSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXZ6</accession>
    <name>A0A914AXZ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069015.1">
        <property type="nucleotide sequence ID" value="XM_038213087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213087.1">
        <property type="protein sequence ID" value="XP_038069015.1"/>
        <property type="gene ID" value="LOC119738258"/>
    </dbReference>
    <dbReference type="GeneID" id="119738258"/>
    <dbReference type="CTD" id="6529"/>
    <dbReference type="OMA" id="FNNINHR"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="72180" checksum="105722D6E270909B" modified="2023-02-22" version="1">MSLVADPHQNSLNKSGEDHVESMPLKDKDGNCNAVDHIFKEPSTRLEDGGDEMQELEDADPPGGKRETWSRNLDFVFACIGYAIGLGNVWRFPYLCYKNGGGAFLLPYAIALLIAGVPIFFFEVAIGQFLSLGGLSIWKICPLFKGVGYAGLVMSFWLNVWYVMPMAWALLYLVNSFTTSLPWEDCENTWNTDHCVANYSISDNYSSTPTDEFWNLYVLNKTETIDDTGNIRWELSLTLLVVWITCYFCIWKGVKWTGKVVYFTSMYPYVMLIIMFFRGVTLEGAVDGIIYYLKPNFKRLGDSEVWLDAVTQIFFSYGTGLGSLIALGSYNKFKNNVYKDALIVSCINSGTSFFAGFVIFSTLGHMAHVQQVDVANVTASGPGLAFRAYPAALAQLPISPLWSCFFFSMIFMVGLDSQFCTMEGFFTACMDEWPKYLRRHKEIFIGITCVISYIIGLSMVSQGGIYVFEIFNNYAASGISLLFLMFFQTTAVSWFYGVDRFYRNIEQMIGYQPFIWWKICWVGLVPALCLGVFIFNMVEFKPLTLDDYEYPPWAIAFGILLALSSMLCIPGYMVYLLLVTPGSIRERFTKCITPNWSEEDLRRGLALPRDANRKMQGPYQDYLPPSYATAVAEGGPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY73</accession>
    <name>A0A914AY73_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068652.1">
        <property type="nucleotide sequence ID" value="XM_038212724.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212724.1">
        <property type="protein sequence ID" value="XP_038068652.1"/>
        <property type="gene ID" value="LOC119738014"/>
    </dbReference>
    <dbReference type="GeneID" id="119738014"/>
    <dbReference type="OMA" id="TFCVETQ"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048599">
        <property type="term" value="P:oocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053116">
        <property type="entry name" value="GATA-type_Znf_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47341">
        <property type="entry name" value="GATA-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47341:SF1">
        <property type="entry name" value="GATA-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="281" mass="31427" checksum="2D83C6ABC140D499" modified="2023-02-22" version="1">MSQQCTWSSKFSNLENYKGFFPSFAEDQLDLSTVFSTGEMRDRCEDLVEVKCDRSKIGSSVVRHAEQTTKQTRKSSPEVSEGNGSSSGSGSGGSSGGGSXRSPGTRRRVLRKAKTPRPSARRNDPRFRGVTFCVETQICREKRHRSQLNIRSFYSIKKKFSQDDQAKGHAKTQRRKLSVVSSTSGSDEAETRVAQRIAIPYAGIVYGDKQCASCLTRRTPLWRDAEDGTPLCNACGIRYKKYRIRCIVCWNIPKKDGKSSCQVCSRCGNALRFTIPKRSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYK8</accession>
    <name>A0A914AYK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068787.1">
        <property type="nucleotide sequence ID" value="XM_038212859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212859.1">
        <property type="protein sequence ID" value="XP_038068787.1"/>
        <property type="gene ID" value="LOC119738119"/>
    </dbReference>
    <dbReference type="GeneID" id="119738119"/>
    <dbReference type="CTD" id="84955"/>
    <dbReference type="OMA" id="DTRFVHH"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="604" mass="67291" checksum="196301E8B0ADDCBB" modified="2023-02-22" version="1">MCTDTLQANRDLLDPHFDGYKLSLDPLPKYSVDVECGIDEVKLRSDQYTLQHVKAFGIHNHLVHDQWNPNCVFYIDKRWRVVQHRVVLESQLQPGRVVFEISHECEQRSRPRHNATLHFTSAELCLLADGAGALYLLATGDRDCADLSTWQILYSEEVCSPATPFVLLHSIAQAKSASFDCLLLRIEEEQTEKTGDDPNDAVTTSGHFTALLDWLTIAKADGESSHRVSRRRRLKSKLAPFYAAIEATGQAVFLAGEAEFTITEDTAKTTTGVQEQDMDVEKDSDTSTEAAAPLYTWTQTGDDVTLVFILPPSTPKSAVNLTLTADTINLGIKDGDELLKGALYRAIDVQMCTWIHENRKLEVTLAKAEEGSMWTEVVIGNQRGDYVIDQDQARIIHERLAHLTSDQLHPDPVPGGSQPGIGPNDLEECDALSDGYSTLVRLDRESHTVTNRVSLSSHQVLFNAQLHPQRPPCICLRHDVDGLLWQPGIGADGDHRSPWQHTATFNALGYVQASKRDRKYSCCPPDCSYALVCDCVRHLYVYRQPSAILSPLRNRKSGRVVSQIAKQQLVSLETTDDILGVAAADDRLFVLTNNQLCVIRVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0C3</accession>
    <name>A0A914B0C3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068961.1">
        <property type="nucleotide sequence ID" value="XM_038213033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0C3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213033.1">
        <property type="protein sequence ID" value="XP_038068961.1"/>
        <property type="gene ID" value="LOC119738240"/>
    </dbReference>
    <dbReference type="GeneID" id="119738240"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="169" mass="18654" checksum="D5E3D6E5F27BC796" modified="2023-02-22" version="1">MPAGLFNQWGIPVQYFPQPIYSGLSEHPPASAPTLTAPGSHAQRPPAAAADDGGHLEIVNVSDDESESSFSAVSTAGREPFRLPHKKDTGINPISEKVISWWEELRTHKLSSDDYKEEISPYNVPSGQGKFFSAPELPSGLKKVFKQITRPSNSGWFPMRFTLLPLPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0H8</accession>
    <name>A0A914B0H8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069492.1">
        <property type="nucleotide sequence ID" value="XM_038213564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0H8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213564.1">
        <property type="protein sequence ID" value="XP_038069492.1"/>
        <property type="gene ID" value="LOC119738651"/>
    </dbReference>
    <dbReference type="GeneID" id="119738651"/>
    <dbReference type="OMA" id="VSCHASM"/>
    <dbReference type="OrthoDB" id="6019940at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="21363" checksum="E65E55A7839FC52D" modified="2023-02-22" version="1">MQQMSTALSDLVLALTSFGTALFILRQNLFASAGFILMGMAASCGAYRFSRSTPSPQVLYWHQGLAWITTILGTSLVASGFHRWYTNSVMSALHMGSALALVCLSKATDILAPRTEELLVSAVSSLAVVSIGIFSVLHTNPFGLLGAVLYGIAAAVGTEGDLASIRRVDWFHYLLAFANVVFLRAFTYASPHVFYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1K7</accession>
    <name>A0A914B1K7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069679.1">
        <property type="nucleotide sequence ID" value="XM_038213751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1K7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213751.1">
        <property type="protein sequence ID" value="XP_038069679.1"/>
        <property type="gene ID" value="LOC119738790"/>
    </dbReference>
    <dbReference type="GeneID" id="119738790"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="52507" checksum="E0AB6343BCE918A3" modified="2023-02-22" version="1">MAPIGEKSTARSAGMENGESEPQNLWSSILGEVSSHSGSKLPSCKNILVLGEDECGKTTLISRLQGTDDPKKGHGLEYLYLDVQDEDQDDSTRCGVWILGGEEEHSELLKFALTPASLSHSLAILMVDMSKPWSIMDMLDKWVGLLRRHIDTLRLPPERLRELEERLVQQFQEYVEPEEGEEPKSPRRTTAPGTVGGEDEKVLLPLGETTLTHNLGIPIVVVVTKSDAISSLEKEHDFKMEHLDFIQQHIRKFCLNYGAALFYTSVKEGKNCDLLYKYLLHRIYGFPFHKPALVVEKDALFVPSGWDNLQKIGILYENMPNINPQEPFEEVVAKPVIRKPLQDSKEVNAEDEQVFLMKQQAMLSKNIPPAKQQESPQRPMGMRTPERKANVASVSPITPSGKGKMEPGKPGATNEGVLANFFNSLLSKKTGTGSPGSPASPKPGDKSVRSDAAAELDRMTRGRKSVPGQNSTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B432</accession>
    <name>A0A914B432_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 10">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19 10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 10"/>
    <dbReference type="RefSeq" id="XP_038070792.1">
        <property type="nucleotide sequence ID" value="XM_038214864.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A914B432"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214864.1">
        <property type="protein sequence ID" value="XP_038070792.1"/>
        <property type="gene ID" value="LOC119739790"/>
    </dbReference>
    <dbReference type="GeneID" id="119739790"/>
    <dbReference type="CTD" id="51196"/>
    <dbReference type="OMA" id="FAMFERT"/>
    <dbReference type="OrthoDB" id="10068636at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01780">
        <property type="entry name" value="RA2_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028398">
        <property type="entry name" value="PLC-epsilon1_RA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="1807"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="13">
        <location>
            <begin position="3031"/>
            <end position="3118"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="3125"/>
            <end position="3251"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="3327"/>
            <end position="3415"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="3489"/>
            <end position="3581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="771"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="922"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1285"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1991"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2042"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2297"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2337"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2816"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2958"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3421"/>
            <end position="3442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3614"/>
            <end position="3644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3658"/>
            <end position="3678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2042"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2301"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2345"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2381"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2393"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2434"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2835"/>
            <end position="2852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2864"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2965"/>
            <end position="2979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2980"/>
            <end position="2993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3431"/>
            <end position="3442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3619"/>
            <end position="3628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3629"/>
            <end position="3641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3667"/>
            <end position="3678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3693" mass="411222" checksum="305DB4397108ADBE" modified="2023-02-22" version="1">MAMGDPSSTVALYYLGSGEVCSPLPGKHVEGLVHLLLLRHLREEKASDGTEGLPPPGRPLGETFGRRVDLLQSGDSNGLRAVDHETGVAFMGCKWYAVGQCSVSSTLRQWFTITVGYSDDKEWTCYIFSAPSRRQARRMVEVIAMRMDGVDPSTKDLPCRRASLQPTLLSHRRSTSLAPKALLSGDGSSRVELRSPLLSSRNLPSRLRKASLSNLRTIPCITALTINMSLLVRQLQSVTGNPNVDADVLRMAILFNDVATVSRVLHTHFNLFNVNYDVVGPGTSKARPRSDSLTVQVLLNQSTALISNWERSQEDGTHHDKPKPCVFTNALHLAIACGSTEVVRLLVKCGVDPNCQGVELPEDLGLSSCQQTNGTDPDGLQYFANQIKTVREWFVKPAVHLATRMANCLIVKTLLRYGADPEAEDSRGATPLHVAAQAPLERWECAAIFIEHGARIFKADNRGQRPVDEAPGLEVLQQKVVQETLDVFYPDKGPDDPEEDVLQQRINSVRDNRKVSLGLLALPRFVAKVARSRSPSARDRCATVCIPQEANAERETPEQIAAVEKRSRKMSLGLWHWLDRRRRSREEPVKSEQDHSDSVPASPIEKMPQPVASEPKLSRSRTHTLDDIEEDACCETFAAERSIQIAQRLSANRECLPLLLEYLPVCLPKLQPLTTSLGGQIGLGVGKMLRNILQACTAPAAGDGTLEGLEADGSHHGSGSLEGIRGERLGKLFRIALQFVRCGQGVRDAALSVVNTVLKLHLKMEESRNSCSFACSPKKPSPGADNGTPKRALRHPHGQSGEHLSVSFNRGVNSKESEAQSAPTSPSLDRIRLKVDGHQQPKSASPGLTRKPSFRYSSNSFYAKRLVLRKSVHSKLGKFARSIGRSAKTKQTSSQPAARSVVRLLTTVDIDMLLDCLQSVSKSSDSEEESSSENEKSSPVRSPAEAGPTQVKQAQRLAARALLTIASLPSTRRALMRPEYLWRLLAVLEPTCDQDFLCLVLQVVEVLVLDPTNHVALMSAGLAQRIDKISRHFDRACASDEQSRTFGALLVLHMTRIRVYMGLLDHIDHRMSKSLLGMEAEVRSSKDAYTDGNPASPIHRDAGTAKGSDGRGRASLLLKMPTATLETLVAMAIGHRPCTEGADRDCRCHSHPEPHANTRHHPLKNPRCKPSGRCRFCCFQDTLLETLPMSVHPVILLRVLEQTLLSTLRSPRNGMQDEAEAAQNNNNLQTKILLMLTRWLDTIPEDFHYNPFIRREASLLMRRLPPLNERFQPLIKKIQGILTSLSEAPPRLKRTPDKPSHPHQQQQHQDFPKHNPSISSTESLRLASHTPEQEDTASVGSSFSRPGSRSTAVTSPLSRFKRNASLNSQGSSCSSVSGLQSVGGLPTAMVKKGSLVYGEDLDQLYQKLNREIIEEHLPCSQEDAVKLAALQLLAESPAHHTPTTHARQQGQQPHHYHHHSNPNQPASTTRQPAMGLPTVTLDMPAEDIETPIIDDFILEDEFGRQSPVPDGETHHGLHQTPLPLHHTPLPLHHHHYSQSSDDRYDIPKTSGCHKPSPDIISDEDSPLPWTGGAVSRGGPNIIVTHSSNIPEDAADKLCLEKVKKCLPHGYSNVRAVQKSAKRCFQCYSGALVDVRDPSERGSRAKQMYVEFCKQLPLYGSRMFHVKEMAGSRLKKKAPRILCIGPKDISLLHPSSKSVLRCHRTALLQNWHIGAYRHGISQLVLEFQGNAKWAVQPLTFVELKAICANLTAVMQKTQENGDVNGEVPANEGSPSTLNKTGQDVTRILETQTSLYLEEFECCRKLLHFPEEVALILTETEHALFCEVPPASYVRQVTNGRSQAMEFVNGEETGSKTVRDLLLRFREVSDWVTELIVTEGEENKTTLLISLVQVANACWNMGNFNAVMEILDGLRNFFDCSRSMLVRPLFQGSDEGDVEAMMALYESINSNSMEYRDAVDRAICIPGCKVVPYFGAFLRELQSIYEENSPVVAVPDSTDKDSENGTPKDATVEYTGGLLHTEKMMRTHWVLTDIRLCRKAAERNNSMEKDTDSEGKDDDDLKSTGKTSYITCDDQEYPYDPIHPVPTPHQIEIIPHHLLERDIHLLQCMHHGTTAIHWDEEKSALCQLRLDPTNSLLVWSKTSPAGEDTESSLESVLSSKYSSGTVIANGLEEGYLDLMSAKDVFLGDQEVDFGAMSKRHNLPGLSPSENAFTVLYGGGIADNRLLHFVAPKKTVLLWAYGLQALIRAIRKHRMFNADRRIVWLQREYLNLFFEDGKCVGPTPLEAIKVFGGRNLAMKKLPNDRNQNADSGSTLNKPSTGFSTPTKKIVIKQKSLVAQKGSDDAKLRNRGRKTQSFKKKAMKKVQTRSAASEAFHGSIDMDDSPSSSMDIPDGSRTTNNDDSGISEPNESAPDSKDYDSTSVSASIITDRSRTDSTRSSTKSRTDSSYSELGQDIPLSYYARKKTHNVSTAGTQGLLTMNSQLTFAEFVELFKSFSLRCRKDIKDIFDSYSKAYSANKEQLPAKSDDGETEYMQGTMFSLSRNMFVEPLTDSNRRVADAIAASSVQANSTGVQTVTTHVMGAEELKQFLSREQEEDLEEDAVLRIIQRHEPTASVRDQQCLSFEGFARFMMDKESYAFNNEERAYKQEEQNHPLSHYFIDSSHNTYLTGHQLKGESSVEIYAQILLTGCRCVELDCWDGDDGSPMIYHGHTLTSKIVFKDVVEAINRAAFVTSDYPIILSIENHCSLPQQARMAQIFLDVFGEKLVTRFMCETDFSDDPHLPSPEQLRGKILVKNKKIKANQLPPELLKHRMMQMAGEQKSQWGAELAAATASMGDISEEEDDEFEDAYEDVLPIDETSGEGPDSKSGTLSRMESTATDISELSDDPSKSISINNNNTANAKTYTSQKSKTSTISSPIGAGEDMHKMVQAKHKKKKEGHQIAAQLSNLVIYTQAVKFPGFAEQPGSSKDKTSKNREKERKGSTSSNASIPGSPASSVKELSLSRGESLDMDRGMSDSLPSDQITSLTQTPKCYHCSSVNENNLKRMFRKFPAQFIKHTEYQLMRTYPAGMRIDSSNYNPVIYWAFGIQMVALNYQTEDTNQITNKTMFEQSGNSGYVLKPVNLWDKTNPLFQRFNAYDKVFDGLQAKELTISIVSGQFLSTTSPNSSYSIEIETIGIPADCAKWKTKPVSRNAVNPIWDETFTFQIYYNEIAFLRLSVVDSGGSTVAQRQVPLKCLKTGFRHVRLRSPQNVPLELASLFVFTRLEDMKDMSDKTKLLEAQQKRQMLSNMVYYHIGRERSSKMEFIEVVDGAEVKREAHPVIIYGIILHDQSTTLKATQETKVHEVIAQALGWAEKPLEDIALYALIEDVQENWEEYPGESKLESRSEERTLEMDERILEVQAGWSGKGRFILKQITELQQDPSYCHHSPSHYPPGHHSPSHLNHLNHLNHLKTSSLRSPRFPRNHRRHRSDECAALDASSAEKTFLVWVYNVSQEQPYTVFRALVASTAQDIIAQAMAKAHRLDADPSNYVLTEEVYKDWKGSEKKDIQEKVTSRVLEDTERVFDVQNQWKTPGRFTLRERDESAVSQYLPNVKAAVSSVVGGSGKKSGFKRLTSMKNRKAGKESKERDGSLLSISSAAKKSSTLPRDFKAEDFKAEFEKMEEADKSSSRSSKSKLLSSRSNLVGKLKRWKTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B450</accession>
    <name>A0A914B450_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070703.1">
        <property type="nucleotide sequence ID" value="XM_038214775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B450"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214775.1">
        <property type="protein sequence ID" value="XP_038070703.1"/>
        <property type="gene ID" value="LOC119739736"/>
    </dbReference>
    <dbReference type="GeneID" id="119739736"/>
    <dbReference type="OMA" id="NAYVMWT"/>
    <dbReference type="OrthoDB" id="118105at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="151"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="722" mass="82597" checksum="8E001C0A0DED82E3" modified="2023-02-22" version="1">MDSTFPMMDECVTVKQEVVSDYETSQSVDNEQGNLYHDGNHDHDKMPATWSMYAENVTESSESKSTVDDSDIDDDAAVMTDRRTRCIGDDLFQYDAESDSDENDTNTLQHHKQDVGEKLPWTRQVATTELRPFSPAVAGPTSEASKTLEAPVDFFHQFFPEELYKEAQIETNNYAEYYQEKRRDLGRDWWEWTDTRWHAVESKQDIKKFLGVCITMAVHTLPDPRDYWSRKKHVCNTLIARSGMTMHHFERVMNYFYLSNPWRDPEKIANPERRVEACSRDPLYKVNKTLHEHVKRSCRAHYQPHRDMVIKELTRNVKSKTDIKTKGWRLLVLKDAYTGYITDLQWYRDTDVNSENSSQGMTQEKALTGLVKNLSGLGHCLYADSVFISPTMAMYFTELGTHVTTDCSNWPGDICTSGDIEVGSTLSVQYKVVTATMWKGKRLKRCLSTMHNGQMQSVTLKLCHPTTREYSIKTVPCPLTIANHMTLVGILPQCLLLSEGTMVQKLTNSWWKRLVWLLIDICMNNAYVMWTESRGNCLSLTEFAMEVASKLMGYPSKACPKRYIEVSTVPATSEETAEASSSHNAAQKAMVSYSMVPEFQVRYPELQPSAVSEASDFQEVVQPDRSSPAHESTDADTDEHCLVKFPGRGRNCRQCCADRRRTRSGRRRDTQFGCSACRVNLCRSGCFVRFHEAHGINISAASMAEVRMQPDPPPYKRMKHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4E4</accession>
    <name>A0A914B4E4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase omega</fullName>
            <shortName evidence="5">GSTO</shortName>
            <ecNumber evidence="5">1.20.4.2</ecNumber>
            <ecNumber evidence="5">1.8.5.1</ecNumber>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="5"/>
    <dbReference type="EC" id="1.8.5.1" evidence="5"/>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038070356.1">
        <property type="nucleotide sequence ID" value="XM_038214428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4E4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214428.1">
        <property type="protein sequence ID" value="XP_038070356.1"/>
        <property type="gene ID" value="LOC119739463"/>
    </dbReference>
    <dbReference type="GeneID" id="119739463"/>
    <dbReference type="OMA" id="XSTIDEK"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="27507" checksum="D05C6E5AEB1A4B7A" modified="2023-02-22" version="1">MPFSPEQTGHLATGDLLPPLAKGQVRLYSNRFCPFAHRARLVLAAKEVPFHIVNIDLKKKPEWYFTKNPLGSTPCYESDDKIVTDSAIICEFLNDSHNNPLWPQDPYQKALDKMVLEYFSSKVSPAFFKSSYYPVKGEEEKWFGEYLTHLAVIEDKLKERGTPFFGGAKPGMLDYLIWPWFERQVVYGAKLPFENFPTLAAFREAMKQDPAVQQAAVPDSLYVKQFNNYINGIYDYDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4K8</accession>
    <name>A0A914B4K8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038070998.1">
        <property type="nucleotide sequence ID" value="XM_038215070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4K8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215070.1">
        <property type="protein sequence ID" value="XP_038070998.1"/>
        <property type="gene ID" value="LOC119739929"/>
    </dbReference>
    <dbReference type="GeneID" id="119739929"/>
    <dbReference type="OMA" id="KNYWVGS"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="263" mass="27893" checksum="AB487F2FC0748C36" modified="2023-02-22" version="1">MAATTANRVLVYGGKGALGTAVVNHFKSKGWVRRVEICIFRMKNEQKPFLLKLQWVCSMDLFPNEDAQVNLIVDPAQSWTEQETSIMGRVEETLSGEKLDAILCVAGGWAGGNAASKALVKSSDLMCKQSVWTSVISAGLAAKFLKDGGLLQLTGAKAALDGGTPGMLGYGMAKAAVHQFVRGLGMSGSGLPANSTALAICPITLDTPMNRKGMPNADFSAWTPLDFVASLLFDWSVGNQPRPATGSLVQLITKDSKTELVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B527</accession>
    <name>A0A914B527_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070591.1">
        <property type="nucleotide sequence ID" value="XM_038214663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B527"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214663.1">
        <property type="protein sequence ID" value="XP_038070591.1"/>
        <property type="gene ID" value="LOC119739652"/>
    </dbReference>
    <dbReference type="GeneID" id="119739652"/>
    <dbReference type="OMA" id="IHWLLFT"/>
    <dbReference type="OrthoDB" id="10461897at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037804299" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20073" checksum="4F8E0B1F6D767316" modified="2023-02-22" version="1">MAHHQVYFIREMSGIVLLFIAVSLGCVWCVDGAATTDAGTTPSLYTTIEADARTDDLPQSDGGTTPNFKDSATSTTSGNTTIVSTSSAAPTEVSPDRYGQIHWLLFTGWQMPLVMVGVEIIAYCVTIFIVFGFGQKRSRIKRFGHFSWKRPNPFVGQDDLASRASTLDSRLKVRKPSVRGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6H1</accession>
    <name>A0A914B6H1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071405.1">
        <property type="nucleotide sequence ID" value="XM_038215477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6H1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215477.1">
        <property type="protein sequence ID" value="XP_038071405.1"/>
        <property type="gene ID" value="LOC119740236"/>
    </dbReference>
    <dbReference type="GeneID" id="119740236"/>
    <dbReference type="OrthoDB" id="5979691at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="81" mass="8774" checksum="6847E6A57B4301D1" modified="2023-02-22" version="1">MKAFVCAAFLPACNENGDAIPPCRNLCLVTKANCQVSMEDLGLEWPSELDCDVFPTSDENPHCISGPAEDGLPLRVVIHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8Z8</accession>
    <name>A0A914B8Z8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038071902.1">
        <property type="nucleotide sequence ID" value="XM_038215974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8Z8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215974.1">
        <property type="protein sequence ID" value="XP_038071902.1"/>
        <property type="gene ID" value="LOC119740610"/>
    </dbReference>
    <dbReference type="GeneID" id="119740610"/>
    <dbReference type="OMA" id="WHENPSK"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002448">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF620">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TORSO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="374"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="757" mass="85541" checksum="3DA76FE3C32056C9" modified="2023-02-22" version="1">MPNLAWTFRRCVLNSDDPFNRPVWWHPSCCDEQTVKRSSITPTFIVRTVGPDQWELDVNVSWARPDRLMNFDAYAVQLDYTKTAYVAYSCVEYQNSDFSFTELEWILFGNVPFGSTPYFIIYTANRTAELINRGSTDRELHLADCYESTENVSFCRTQDVEVAGRPIGLKVDSLIGTWRLGGVTLTASVTVSWNPPAQINGEMTGFEVVWSVNGSRLVPSTTIDVPMNLSEYSDPLSLSFNHSFIVDDVENESNLKIEVAAKVNQSDEVLVGNAAVLSITVGPDNFTVPTAGPPTNIVLYVVVGAAALSSCIVVLAITCCICRRKRRPRQDDKPIIQFKRRHMESNYVVEPRVQSKVDECFAEAECDRNVLTEISTIALIGKGSFGVVYKGFAYGTVNGKPDYYPVAIKGLKENAAADMKQSFLEEIRLMIDIGRHPNILSVLGCCTIDEPYLLITEFMKYGDLLHFLWKTREIKMAEVDPMYCLTELNQLQIARQVTCGMEYLSQTRYYHGDLAARNVLVGDNLIVKVSDFGLSDDTYEMGYKRMDESKKRAVKWVSLETNTTNRCSIKSDVWSFGVVLYEIFTRGDAPYQGLSNQEVVEKLKSGYRMGQPDDCPSDVYAMMRECWHENPSKRPSFTHLYKSLDKMMLRHSDYLSFEESASSLNEPQDKVINTDRTQKHAKDTQHGNFESSEFSGKSDELELWLHLKGPLPDGDRTIEFVPQAGEDSIQSDTPTKGKADVKFRSFKRDRDCDVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B974</accession>
    <name>A0A914B974_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071982.1">
        <property type="nucleotide sequence ID" value="XM_038216054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B974"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216054.1">
        <property type="protein sequence ID" value="XP_038071982.1"/>
        <property type="gene ID" value="LOC119740679"/>
    </dbReference>
    <dbReference type="GeneID" id="119740679"/>
    <dbReference type="OMA" id="WESATAF"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037365388" description="C-type lectin domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="176" mass="19997" checksum="79325B3222CA262F" modified="2023-02-22" version="1">MSCFVYIFVSLALFLSSGLNLSPSCNRRHGLCTAPWKKWGGSCYLITQKPLTYDDAREACRRLGAKMAAPRSDQENDFLANLTQGSEIWVACTDRRQEGEWECEGSQDGERIYTNWIDDQPDNGGGKEHCAAIWSPDNKWNDYRCKRDLLAVCKRQPRTHCFTTNSEGRLEADSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B982</accession>
    <name>A0A914B982_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072738.1">
        <property type="nucleotide sequence ID" value="XM_038216810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B982"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216810.1">
        <property type="protein sequence ID" value="XP_038072738.1"/>
        <property type="gene ID" value="LOC119741118"/>
    </dbReference>
    <dbReference type="GeneID" id="119741118"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="534" mass="58493" checksum="CBAC7C8C6796DC14" modified="2023-02-22" version="1">MELNVNNNANGDDADDSAAYAKEHSHSKGKKSLGKFFSRKGRQTIVQIPDEDTADEVGLHGVDSLHSSRSDEEWNEAIHRDEPDGEHQEKHFEFERAEPKDELEKLASLSVVKAVRKRFGGVMSKENNQNPSDKPRKQVPENKTAQISGGSDKEILEFLKAQTKLRRVNPSGKISVSEQTMNKVPVERSKQVQAEPKFVCSTDSDDKESPEFVKVQTKLRKVTPPDKIAITEQDQMMSQPPVESTESIQISPKPTKPNQSTVNQASPTFAGVGRVMYQITDASPSTKNVTTLDTAELQRIIIQQQEEMRLLRRQMQASQLQAAQMQPAQMQQAQLQASQMQASQLQAAQMQASQLHASQLQATQIHASQLQASQLQAAQLQASQLQATQIHASQMQPSSLPNTSQSQPGNVGSMSAATAPHVPSMPFMYSQPNMMMSAVQQPMYYLPHGMQPSGAGMQGPGVQMPGVLPLGNFSSFAPFPVQGMLPMQTQLPPMGMQVQGSVTQYPTTSHLPTMTTAGGSFGSTLGMPEQKHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCP7</accession>
    <name>A0A914BCP7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073819.1">
        <property type="nucleotide sequence ID" value="XM_038217891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217891.1">
        <property type="protein sequence ID" value="XP_038073819.1"/>
        <property type="gene ID" value="LOC119741935"/>
    </dbReference>
    <dbReference type="GeneID" id="119741935"/>
    <dbReference type="OMA" id="DAMAYEV"/>
    <dbReference type="OrthoDB" id="1712432at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="38998" checksum="3E2512438F335E61" modified="2023-02-22" version="1">MRNHLCCSMSKLLSARCLCRAALVVLFSVTFASVGLWMHSKTLLDVTRGVPPESLNETSFLRHEAEFEKQDHLLTVKPSSRASSFADEVRALAKALPERKIVLTTTNSGFLDFTQNMLLSIQRVGIHPEVVVICEDTTTYKTLRLNDSYGVHVLKPPNAIPEAGEALSFGVHDYVTFINNRPKYTHEFIKQGFEVFFIDSDTFWFNDPFPYFKGDQYDVAFMRDYRRVFNAGVGFYRPTNRTEYFLRFWIWILETQPKHRQDQHVLNYLLSSKLNAGIKVRSLSFQVFPTGKILYDWDHEVCRNVTKKTTFFHAAFIPNHDNKKKVFDICKIWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD18</accession>
    <name>A0A914BD18_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073327.1">
        <property type="nucleotide sequence ID" value="XM_038217399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073328.1">
        <property type="nucleotide sequence ID" value="XM_038217400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073329.1">
        <property type="nucleotide sequence ID" value="XM_038217401.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073330.1">
        <property type="nucleotide sequence ID" value="XM_038217402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073331.1">
        <property type="nucleotide sequence ID" value="XM_038217403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217399.1">
        <property type="protein sequence ID" value="XP_038073327.1"/>
        <property type="gene ID" value="LOC119741588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217400.1">
        <property type="protein sequence ID" value="XP_038073328.1"/>
        <property type="gene ID" value="LOC119741588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217401.1">
        <property type="protein sequence ID" value="XP_038073329.1"/>
        <property type="gene ID" value="LOC119741588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217402.1">
        <property type="protein sequence ID" value="XP_038073330.1"/>
        <property type="gene ID" value="LOC119741588"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217403.1">
        <property type="protein sequence ID" value="XP_038073331.1"/>
        <property type="gene ID" value="LOC119741588"/>
    </dbReference>
    <dbReference type="GeneID" id="119741588"/>
    <dbReference type="OrthoDB" id="9901374at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="184" mass="20335" checksum="64DB12738057C341" modified="2023-02-22" version="1">MSHSKGNTSIELIKEKMKEKRRKKALNDSNTSWSRSFSKRKGTTASIILIARLRSNLAASKRDAQQARQNILELQRERQFLQQANSRRMAEKECTQRFGNIKQVLSKVTPSLLDAVKSIGLAIDLCSSLPLRESSLGLIPRASSTSDDDSFRIMQKADQGQAQLSSAIESAASHVMQAADSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BD89</accession>
    <name>A0A914BD89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retinol dehydrogenase 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073397.1">
        <property type="nucleotide sequence ID" value="XM_038217469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BD89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217469.1">
        <property type="protein sequence ID" value="XP_038073397.1"/>
        <property type="gene ID" value="LOC119741637"/>
    </dbReference>
    <dbReference type="GeneID" id="119741637"/>
    <dbReference type="OMA" id="MESHRIA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37340" checksum="95C20C973464B4F7" modified="2023-02-22" version="1">MMALPAWFDGWNFTTVVWTVVPVGVAVLWLLRRYLAGGWCYNKARLDGKTVLITGANTGIGKETARDLARRGARVILACRDLAKAEAAMTDIREDTGNSNLAVVKLDLASLASVRACAEKIKREESRLDILINNAGIMMCPEWQTEDGFEMQFGVNHLGHFLLTNLLLDLIKSSTPARIINVSSIAHAYGKMNWEDIHMKEGYNGGKAYCQSKLANILFTRELSRRMKRKCTGVSVNAVHPGSVDTELGRYLQSQGGLMLIFLKVFYPFFKFVMKNAVQGAQTTIYCAVTLELMHFSGFYFSDCAQKTPAPQAMDDDAARRLWDMSAKMVGLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEL6</accession>
    <name>A0A914BEL6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PRP39 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073857.1">
        <property type="nucleotide sequence ID" value="XM_038217929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217929.1">
        <property type="protein sequence ID" value="XP_038073857.1"/>
        <property type="gene ID" value="LOC119741958"/>
    </dbReference>
    <dbReference type="GeneID" id="119741958"/>
    <dbReference type="CTD" id="55015"/>
    <dbReference type="OMA" id="SMDKVEM"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000063">
        <property type="entry name" value="Pre-mRNA processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000091">
        <property type="entry name" value="Pre-mRNA-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAP" evidence="11">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="823"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="869"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="996" mass="111317" checksum="A3AECC634CC65098" modified="2023-02-22" version="1">MAETVMDSTIEAPENGQIEPQKSEASVISDDYDPSIPTDEKGSVAEFTPSKMKVAELRTELMNRGLDAKGNKAALVQRLEEALDTPQGEVSTPQQPGDEDNGDEEDEDEVTMITPEDIGGKDQEIGDLEMLAPLQSKEESGEGDVDAVEEIDDEGESSATENIEEQGQIEMEMETETAAAGQEQKQEEPMEQEPTEKPTSKPLVPKAKPAEVPAAKEKPKQEPKVVAKPQEKVVEKSKPAKGATKAPAAKAKEETKKPEVEKGPPPELQKYWKAVKDKPTDFTGWTYLLQYVEQQGHMPSVRDAFDAFLARYPYCYGYWKKYADLERKKAKNTEKAQEVFETGMKAIPLSSDLWMQYIQFVGQTASPEEVTDRLRSVYSKAIAAAGTDFRSDKLWDMYINFEKDKQEWQRVTKVYDQLLTIPTQLYSHHFEKFKEHIKKHHPKDSLSVDEFIKLRMEVVEVLGVVEPGIEEGDEGGDDAPPGDDDAPPGVEIAPPGLETPAAKKAASSKQVEMENEAIRKKVLESRGAVYRQTEQEVSKRWAYEEGIRRPYFHAKPLEKSQLKNWREYLDFETANGTHERVLILYERCLVACALYEEFWMRYAKYLEPHSIEGVSSVYKRACSIHLPKKPSIHLRWAAFEEKQGNMTAAQEILQKLEENVPDLLMVSLERLSLERRLGNKEEVVGILRKRMGASKKPEIKAFFAMKLSRYYAKVMNDIDNARKVLQDAVQWAKDKVTLYLQMLDLEMQQIPSDEQAILDLLQKGIEVSKDMDDKMKFSQRRLTYLMDFGTDVAKLQTAYESHQVLLKEQLEILQVANKKRSAETSGASDSAQCQLPGAHASPNTAAAVATPAKPVQRGVAFAGWKRGSDLTSVKGESTPAATPAKKAKTEDSKASTTPTPTTPTTAATPSKPHPLLSNPVSNPSGPAAAQDYNQPPGPNPGWGGYNQPQYGPQGGNYGPVPPGPGGYNQPPPNSYNQQYQQYQQAWGNYNQGYYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BER4</accession>
    <name>A0A914BER4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074365.1">
        <property type="nucleotide sequence ID" value="XM_038218437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BER4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218437.1">
        <property type="protein sequence ID" value="XP_038074365.1"/>
        <property type="gene ID" value="LOC119742497"/>
    </dbReference>
    <dbReference type="GeneID" id="119742497"/>
    <dbReference type="OMA" id="KTCCEIC"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="569" mass="64438" checksum="A964A78331A9632F" modified="2023-02-22" version="1">MGTTSDSSVARYAEHLAHQSTPIVSSEVGHPDVFLVPLKMQSVSSTQTFRSYSCGVPSRMHSPHKVIMVVGETGTGKSTFINAMINYILEVKWEDNFRFKLVHDRGEASGSQAYSQTQNITSYTINNNYHINVPYTLTLIDTPGFGDTRGIERDKAIVEQIREFFSHPEAHGVDHIDAVGFVVQSSQARLTPAQKYVFESILAIFGKDIESNIVLLITFCDGQSPNVLEAIHEAKLTFDKTFKFNNSALLASRGDVGMSFDAMVWQMGYTSMKEFFYVLDDLQPQSLSLTVEVLEERKSLEVALEGLQSQILFAWEQTEQLKKDKKILEEHEKEIQANKSFEYMVNAPKLEKVRDEDKGSTNCSNCLYTCHHPCTFSQGKLLCHAIKKGYCTVCPGKCSLSDHVHEYFRYHWKMVKEKQTYADIKNQYRDAQGRKQTREEVIKCIETDLVKSEAAVSELIDESHRCTQRLREIALKPDPIGVMDYLDMLIESEKETKTEGWQMRVVSLENAKRQANTKAVVKDAHSLGNIRGRHTNGQKLSSEEITKKVEAESGKSRCLILSAIKDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF40</accession>
    <name>A0A914BF40_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074863.1">
        <property type="nucleotide sequence ID" value="XM_038218935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF40"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218935.1">
        <property type="protein sequence ID" value="XP_038074863.1"/>
        <property type="gene ID" value="LOC119742764"/>
    </dbReference>
    <dbReference type="GeneID" id="119742764"/>
    <dbReference type="OMA" id="VEEMSMI"/>
    <dbReference type="OrthoDB" id="9978016at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19697">
        <property type="entry name" value="bHLH-PAS_NPAS4_PASD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056192">
        <property type="entry name" value="bHLH_NPAS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF39">
        <property type="entry name" value="DYSFUSION, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23183">
        <property type="entry name" value="bHLH_NPAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="156" mass="17583" checksum="47AC914C21F04666" modified="2023-02-22" version="1">MHRSTSKASKQRRELIKTEIDRLRELLPLPNAVKARLSFLHVMSLGCVYVRKGHYFNQDQDVVPPVPIWDDTSPFDFTQALHGFLLVMTREGKLLYISENVTDYLGHSMVELLSTGGDLYEVIDPRDHAVVRGQMAVGSSCGGAEAEYQPVSHKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG17</accession>
    <name>A0A914BG17_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075034.1">
        <property type="nucleotide sequence ID" value="XM_038219106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219106.1">
        <property type="protein sequence ID" value="XP_038075034.1"/>
        <property type="gene ID" value="LOC119742876"/>
    </dbReference>
    <dbReference type="GeneID" id="119742876"/>
    <dbReference type="OMA" id="FRELVYW"/>
    <dbReference type="OrthoDB" id="412240at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07207">
        <property type="entry name" value="Pat_ExoU_VipD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052580">
        <property type="entry name" value="Lipid_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394:SF1">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="51"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="629" mass="72302" checksum="BB203886757595A8" modified="2023-02-22" version="1">MEQGKPMSSMSSKFKKTFRFKTVKTPKVHNAILTDSEVDELSSYQYPWHNIVFEGGGNKGLAYCGAVRVMEEIGLWSQVKRIAGTSAGAMTAGLLAVGYDSHDLEAFLKQPELEKIFLDARFGIFSVLPNMLKRFGWHPGHRLYSWFGKMMYKKTGNADITFEEVYKMYGKELCICVTNINFLDCYYCHVKTTPDLPVRMAMRMSGGIPGVFCTVKSTLSSFPDHYVDGGLLVNYPIHAFDGWYLSMRPEDTFLKKVQPLRDIRKLWDRKERFGHKNERTLGMLLYSDFEPEVMKDALNERHSYYQDYVQAVPPTKLAKKRMKKVSNEYIEAQHNSLVEAMDKLVAELNKQDLNMDGNITLDEWKKAFNNEDSGFTDSYKTMLFGEEGLDPEKIFNKLDFDQNGEVSFRELVYWAEKRGLKLLSAFRGYERREITSMMDFFATMMECLLLNMKRIFIQDNDLYRTIGIDCKYLDAMDFKMEPKDQEFLIEQGKLGCMSYLREFVDKFKPAPRRKNKNEVNRDSKKLHRVTMEFSRLLNSESDFEGMVSPTPPQSGVPENAPDDDVFSNQMREANVKAAQSSTAENNDKKDKVTCHKRVTIALPDDDKDSSASAASCEDAELIPEANTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG63</accession>
    <name>A0A914BG63_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038075248.1">
        <property type="nucleotide sequence ID" value="XM_038219320.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038219320.1">
        <property type="protein sequence ID" value="XP_038075248.1"/>
        <property type="gene ID" value="LOC119743013"/>
    </dbReference>
    <dbReference type="GeneID" id="119743013"/>
    <dbReference type="OMA" id="QCEPISS"/>
    <dbReference type="OrthoDB" id="6490717at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1155"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="495"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="597"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="702"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="797"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="902"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1275"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1448"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1559"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1735"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="880"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1842" mass="201403" checksum="E10EA2201248C3EF" modified="2023-02-22" version="1">MAMPCYDHLTRTGLHGRPAYAQLISLGVFLSVSFTFGALPDFTCYNVSPVLASNHIIGGYKSGSDINAGVSFERVLDTGGGETLPTGSYSTDERPDINLYAGKYTMPSAAGDTRIGVYNCIFDQPSTNITTIILPANGDIQPQSPTVTTSVGENVTLTVTFSASVAVSDLRWKHNGHDVTEWNGQSAVTINDADAINAGIYECYQDGNWAAQKHALMKLIVRECPVNKWGSSCDGNCPVCHNGGMCDDRSGKCLCAPGFTGDFCEILFGKNRFGHDCGITCSQRNIDGCRGNLMCLQDPFGCTCAAGFTGLDCRSPCVDGYFGAGCSHQCHCDGAAVCDKGTGTCPSGVPCEEGYRGENCQNSCQPGEIGVDACVTCPVPIAVKNFNITVSSTTTRQLAWSAASNMCPVSNYSIQHELVNQDQCQPASGNYIDVATVDTQSSSYTWQVPNDDDPQYLPYSTYKIRVRAKNEAGLGQFEGVTFDEFTTAEGRPHAPPDNVEFFNSTDDSVSFQWDEVPCGSRGGLVTLYIFDLSTTNDVQPRRSSYEMSVRIDDAILPCTDYTLQVAALTTYGPGPYSNRTSVTTSSRGNFGPNAHGPVENLNTSAGPAPDELQVSWDAPDTSRNPCSIEFIVEYELITRDQCETLSSPRRVPYGLGGDTGLIIAGLEAHSTYKVYVRTSNEAGESDEKSIQSITSSKAPQAPPSNVEFFNSTDESVSFQWDEVSCGSRGGVVSLYMFNLSTAFDFMSGSSYEMSVRIDDAILPCTDYTLQVAALTTYGPGPYSNRTSVTTSTRAHGPVENLNTSAGPAPDELQVSWDAPDTSRNPCSIEFIVEYELITRDQCETLSSPRRVPYGLGGDTGLIIGGLEAHSTYKVYVRTSNEAGESDEKSIQSITSSKEPTKAPADFTSTNQTKTSIRLAWGEIPCGERNADIVGYSLDYRVLEKPYNKTFKPSASFTPVDISESAMLHTVTGLEPSTKYEFRLAGVARLDVDTPGPYGVLDINTAVETDIKPPAEPSVESSLTTSSTVTITLSPPAVSTYITDFQISVQPVGQASDVPVRAGLRHYGPSSAVSLDNRYVTAEFSKEDLPDTFTVGDNGTYGGYRNLPLQAETAYDIYLGSVSSTSDTETVVFREEPLRVKVAGSNFGNNDSQGGFPVAALVVPFLLIILVGLAVGVIFIRRRARKQTLSSDGINLDSSNDLKDINLGTFNAAEEICNSEEAASIPSVPSQSLVVAAKPKPTQRKRQASHQPVALADFEDYVWKKKHDLHGDANGFLRDYKSLPDGTLNPSSVARHEQNRAKNRYANIIPYDDYRVVLEELPDDPYSDYVNASYIDGFNEANRYIASQGPNKASVTDMWRMVWQKNTSKIVMLTNLLEGVKSKCAQYWPDDTATYGQLTVRLQAEERHVDYTIRDFKLQKEGQSTRNVRQYHFTSWPDMGVPYDPSKVISFVKMVKAYSSKDTGPMVVHCSAGVGRTGAYIVLDAMLDQARIEGKVDIWNFARRMRDRRMKMIQTAAQYEFVFDALLEEFKYGGTSIQADAFRSELAGLKKTNSNRTTGLQEQFEKLTRLSSIVSSDQCLGGRDPKNVGKNRFPDKLPVDRFRPRLMTEGGDGSTDYINACFLSSHSAKGAYIATQMPLPGTVGDLWRMVYDYNCSCIVMLNNLDDKDPTFGKYWTDAGSLTCPPLDVSLESTEKMPNNITVRYLTLTNAKTKVSRMLCHLQLPDWPSGRVPASPVTVLQLVAALREWQCDHTETRIVIHCIDGEGASGTFCALLNILEKLKDENVVDVFHAVRKLREARPGMVQSLEEYTFLYDAVRTHMESDIVYENVQAASIHVSCTSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG81</accession>
    <name>A0A914BG81_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074911.1">
        <property type="nucleotide sequence ID" value="XM_038218983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218983.1">
        <property type="protein sequence ID" value="XP_038074911.1"/>
        <property type="gene ID" value="LOC119742806"/>
    </dbReference>
    <dbReference type="GeneID" id="119742806"/>
    <dbReference type="OMA" id="FRCKAKK"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="438" mass="49500" checksum="C8BFB1E4E00817CA" modified="2023-02-22" version="1">MAEGGVTDLVLDETQKELQECPICYTEYKDPRKLDCSHSFCLKCLQELKLTQNKDDKHIVCPLCRKETALTEAGVDMLPGGSKDVNQQEQTEGQGLKVMCQACDEAENEAISRCMDCKHYLCQECQKAHNRFAALKSHKIVALTELPVEPEEITEDTELKKVPKCREHPDQDLCLYCNTCEVLICNECTNIDHKGSIHSHVSIDQAKAEKEIAKIREKEQQLKMEARDIATKREKQFAYAVTSEKILGKVNKVMTTATCYEILENKKKMLRDLNEQVEVHKSLDIKHGKSFLGFKESKEDGQFGTLLLEEKWETDEAFSEYVQGRDYRHIAAYSTSEIAVVQSDKLLTLGIKGKVISTKTYKPDPDKPNEPHDPNDIQKATALAINKDDQLLILDNPAVKIFNKEYQLLHQFLPGKEAGVDGMPTCLAVDSSNLIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BG93</accession>
    <name>A0A914BG93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075114.1">
        <property type="nucleotide sequence ID" value="XM_038219186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BG93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219186.1">
        <property type="protein sequence ID" value="XP_038075114.1"/>
        <property type="gene ID" value="LOC119742922"/>
    </dbReference>
    <dbReference type="GeneID" id="119742922"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="127" mass="13960" checksum="475C3AF658704A36" modified="2023-02-22" version="1">MDSPKPLLRLQARQHITALGEEVPSALNKLSASLRQSPAKKRLFPATSPTTPKRRPESIPPSRPTKVYLPSRSHNKQTDNPSDDILSQAGWSDIEALPDDAFNDEIADGPLTNIPLTDTETPPETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BH94</accession>
    <name>A0A914BH94_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074807.1">
        <property type="nucleotide sequence ID" value="XM_038218879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BH94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218879.1">
        <property type="protein sequence ID" value="XP_038074807.1"/>
        <property type="gene ID" value="LOC119742711"/>
    </dbReference>
    <dbReference type="GeneID" id="119742711"/>
    <dbReference type="OMA" id="WNLIWIV"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="939"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="981" mass="107122" checksum="86B0210FF51324EE" modified="2023-02-22" version="1">MEGKIKGNDSVVCETEPLLNRRAPKLSGRERAASRWVTVEPLLLLAACSYMLTAVLRIQYVLVRVQESYNYTVHTDSPCPVRNQTGNISYISDADTQARIQADSARWMLFFSLVGALPGFFSAIFMGALSDRFGRKIFLNLSTIGSASFAGVCTAVMAFNLRLEVFYAADLAFGLTGGQMSVLSLCYSYIADVTTKKQRTFRIVVIETVFVLAGLFQVGAEYCYEALGFATTAGIATGLGVLAFIYSVIPHILIETIERKGQQPLVQTLRQTVRGVGRLFYSEGGAVRTWCLLLIFATLFMLTPMESSLQVRTLYVQAEPFCWSPVTIGYNAALFSTVILVGNIGGFKLLSKCFSSQWIFHISCFSTVGVYVVFGLVRTTELFFWAILLTVITGLCFPVLRGTLSQLVGADEQGVALSFLACVENFGMYVSPIAVNAVYMATVASYAPLGFFVIAGITCVPPVLFGPYTYAREILWMFKITSIKPNKTSHGIFNMEGKIKGNDSVVCETEPLLNRAPKLSGRERAASRWVTVEPLLLLAACSYMLTAVLRIQYVLVRVQESYNYTVHTDSPCPVRNQTGNMSYISDADTQARIQADSARWMLLFSLAGALPGFVSAILMGALSDRFGRKIFLNLSTIGSASFAGVCTAVMAFNLRLEVFLAADLAIGLTGGQMTIVSLCYSYIADVTTKKQRTFRIVVIETVYVLVGLTQIGAEYCYEALGFAATAGIATGLGVLAFIYSVIPHILIETIERKGQQPLGQTLRQTVRGVGRLFYSEGGTVRTWCLLLIFATLFMLTPMESSLQVKTLYVQAEPFCWSPVTIGYNAALFSTVLLVGNIGGFKLLSKCFSSQWIFHISCFSTVGVNVVFGLVRTNELLFWATLLLVLSGLCFPVLRGSLSKLVGADEQGVALSFLGCVENFGMYISPIAVNAVYMATVASYAPLVFFVIAGITCVPPVLFGIMHVVIKRSIDPQILASHTVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI51</accession>
    <name>A0A914BI51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038075575.1">
        <property type="nucleotide sequence ID" value="XM_038219647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219647.1">
        <property type="protein sequence ID" value="XP_038075575.1"/>
        <property type="gene ID" value="LOC119743243"/>
    </dbReference>
    <dbReference type="GeneID" id="119743243"/>
    <dbReference type="OMA" id="ENKECKA"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="500" mass="57048" checksum="54BC536DF093C79D" modified="2023-02-22" version="1">MLVGATGAGKSTLINRMINYILGVKWEDNFRFKLVDEHLPMGKTQAHSQTQMISAYTIHSNKQHTIPFTLTIIDTPGFGDSRGIERDKAIVEQIREFFSHPEAHGVDHINAVGFVVKASEARLTPTQRYIFESTLGIFSKDIKPNIILLANFLDGITLPVLDAIMAANIPFSGCVFKFNNSALFTENKECKAESDSDEAEEEKALKLYWKKGMKEMQRFFETVSKLEAKSLTLSKEVLEHRKQLEQKVERLQSQSAIYRDKMEELQKEQEALKHCQRDIKVHEGFQCEIEVIENEKIPTDVGSLNCDICQFTCHYPCTKPDKKKKKCHMMDRKGYCMVCPNKCVWSAHVIMKCRHVYTEKKRMKTFTDIERRYRDAVDKTLTVQELIGKIQSDLENVKQAEVCLFLEIHKVLQSLEEIALKPHPIGFTAYIDLSIKSERDEAKTGWEKRVKTLESYKSQHLLVDSVKSVVPQGSGTTLEATTGSNTGSNDWEQTPTDCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI56</accession>
    <name>A0A914BI56_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075580.1">
        <property type="nucleotide sequence ID" value="XM_038219652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI56"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219652.1">
        <property type="protein sequence ID" value="XP_038075580.1"/>
        <property type="gene ID" value="LOC119743249"/>
    </dbReference>
    <dbReference type="GeneID" id="119743249"/>
    <dbReference type="OMA" id="ESWEFTH"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="239" mass="26921" checksum="6F2447A7A3BEEAA1" modified="2023-02-22" version="1">MSSAAVIDTLKEQFSRHGIPEELRTDNGPQYSLSEFSKFCKDYEIQHITSSPYNPQSNGEAERAVQTVKPPWKKCPDRHLAVLDYRTTPLASCNISPAQLLMGRRPRNKLPTSKSLLRPKLYSTQEVKQRFDNDKTKQQFYYDKKAGQNPPALISGDPVRMAPLPGTNRWLPATVANHHSTPRSYVVEHNGRKYRRNRRDLRLATHGANKPLHCTPADSDHVTLPVTTPVATSANGQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ51</accession>
    <name>A0A914BJ51_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076308.1">
        <property type="nucleotide sequence ID" value="XM_038220380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ51"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220380.1">
        <property type="protein sequence ID" value="XP_038076308.1"/>
        <property type="gene ID" value="LOC119744450"/>
    </dbReference>
    <dbReference type="GeneID" id="119744450"/>
    <dbReference type="OMA" id="GRKLMAM"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01907">
        <property type="entry name" value="WORMGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="17455" checksum="BBF6160D775C5BC6" modified="2023-02-22" version="1">MADTEAAPLSSVQINAVQESWKIIVANSKENGVTLIKRMLTEHPEILHLFSFGRCGLSGEAIFQQPMFHRHCQYVMESLDAAVNGLIDLTALVPVLEKLGEKHKSFQVKREHFQYLQEAFVFMLQKALGDDLTKNLAESWLAVYAVMVDTMASKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJU0</accession>
    <name>A0A914BJU0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038076553.1">
        <property type="nucleotide sequence ID" value="XM_038220625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220625.1">
        <property type="protein sequence ID" value="XP_038076553.1"/>
        <property type="gene ID" value="LOC119744599"/>
    </dbReference>
    <dbReference type="GeneID" id="119744599"/>
    <dbReference type="OMA" id="TQLMKHW"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16211">
        <property type="entry name" value="EFh_PI-PLCbeta4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000084">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="13">
        <location>
            <begin position="584"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="703"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134192" checksum="A4BFC3FD150DA615" modified="2023-02-22" version="1">MHMVASSAELAQEWFDGLLKITHNFKANNVCPMTSLMKHWMKICFQVNPSGNIPVRNLTRTFASGKTEKIVFKSLEELGLPSGKNDEIDPQTFPFSKFYDLYHKICPRTDIEDLFKQISKSNQEGLTVSELIEFHNEKQRDPRLNEILFPFYDRERILKIIHTYEKDPEVVKRDQLSVDGLCRYLMSDENAPVFLDRLFLYQDMDQPLSHYFINSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGRNEDQEPIITHGLAMCSDINFKDVIIAIRDTAFVTSEFPVILSFENHCTKFQQYKLAKYCEEYLGEYLLKEPLADHGLDSGIPLPSPNKLKRKILIKNKRLKSEVEKRQLEQLRLKPGTIMNLEDEEDEEPESDSDSEDDVPPPSASVVSKRTRRQSKLSDSPDNEEAKKEDNNNEENSEETPSEETAEDKEKTGQQPVDAHPELKVLPGTNKIGSTGDLENVAGEAAKAPVDTVTKPPTPAPPAEKETPVGTPETAEPVKLKPSLSMKNSNKKNLSRVQLLDARAEAKAKAEALAGENLQGVEQLSQDEEAFMVANYRYTGATTNIHPFLSALVNYAQPVKFQGFDVAEERNFHFNMSSFNEAVGLGYIKTSCIEFVNYNKRQMSRIYPKGGRYDSSNYMPQIFWNAGCQMVALNFQMPDIGMQLNQGKFEYNGSCGFLLKPDFMRRPDKSFDPFSESPVDGVIAATCSVRVISGQFLSDKKVGTYVEVDMYGLPTDTIRREHRTKTVPNNGLNPVYNAEAFVFRKVVLPDLAVLRIAVYEENGKLIGQRILPLDGLQAGYRHISLRTEGNFPLSLPTVFCCIQLKTYVPDGLGDFVDALSKPLEYLSQAEKRAKQMQSMGIEENDISEVPLGGKKSSKSTLKQGAKSPTTPTQSVNSFAPTTNSVMLILSTDTLQKDKVYQKVLKKQSREIESLQRKHSKECTSVKRTHDTAVDKMAVSHDKEKLTEEKSLEKAIKKKGESNCSDLKIETENKVHSIVKVHKIRVKGVVSEQGKEWCKVTARQTAEINALKETHVYQQCDVLRKLMTQKQIDQRKTLEAKHAREMKDLEANQCKMSMESKKLVSHDKSIKNKAEKDRRIRELQSNSLKKFMEERKRLQVRQSKENDELTAEHNKQMDLLIRANEEMIEAHKAKLTETNNSNSKVEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL66</accession>
    <name>A0A914BL66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RETREG1-3/ARL6IP-like N-terminal reticulon-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETREG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077033.1">
        <property type="nucleotide sequence ID" value="XM_038221105.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221105.1">
        <property type="protein sequence ID" value="XP_038077033.1"/>
        <property type="gene ID" value="LOC119744907"/>
    </dbReference>
    <dbReference type="GeneID" id="119744907"/>
    <dbReference type="OMA" id="IKGAQLW"/>
    <dbReference type="OrthoDB" id="10029527at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22558">
        <property type="entry name" value="RETR_RHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043384">
        <property type="entry name" value="RETREG1/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28659:SF2">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="11">
        <location>
            <begin position="54"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="546" mass="60751" checksum="70DB6942658829AB" modified="2023-02-22" version="1">MTQTKTXVNINMDEYGEGVVVNPVKSNFSDAEMRESERQAEVKHREQRLRQFLGPLEGFIMSVQSLLVWEKPARSAVMVLCVNGLFWLAVTTHYRAVFLGAVSCMVFVSMETIRTKVWPEIRVPRPDDDDEGWTPVHAKLLSLPELCEHTARLWVTMEGLNTRMWKLRREHPSKFCLYVCSLCLVMAAVGHYFSGVFISYLIVTGLLLWPALEYHNVTGSLYQRIGPILQQLDHSIDSPRREKKRAQKRARNRSNPTADTDSSSDSDLDEFCPTPGPAVDAALAHAAGRSARNSSGTSVGLFGGLSKGLSLEFTDDEFTDTEPPSYMGGLSQVPSFDNTAYDHSADELEIDLPYDDHPPVPGNPEKSKEQGGREKQRSPEGMPFDPSHFRDSTDVDEALAEDLEFPDVEADGKLGRQNSRGKQTRDEPLLPPGAAMLLSHTVTSLMSDVLTKLQDMGSQDDNSSTSEPSQVLRQRKLPESETSMDRNPSPPKLLTMDSDSTDFEMLDRAELEQEGGQVAGEKKDEAKPRRSGYGIGLLTSWLSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLS6</accession>
    <name>A0A914BLS6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076721.1">
        <property type="nucleotide sequence ID" value="XM_038220793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220793.1">
        <property type="protein sequence ID" value="XP_038076721.1"/>
        <property type="gene ID" value="LOC119744719"/>
    </dbReference>
    <dbReference type="GeneID" id="119744719"/>
    <dbReference type="OMA" id="WIAMHEN"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18299">
        <property type="entry name" value="BTB1_POZ_RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18300">
        <property type="entry name" value="BTB2_POZ_RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000202">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="337"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="508"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="695" mass="78386" checksum="0FED875406DE9DFB" modified="2023-02-22" version="1">MPKHAKKKIPEVKIVIVGDGHVGKTCLCISYTTDHFPREYIPVNFDNYSWNAVVGGKLFAHGLFDTSSTGEDYDRLRPLSYPGTDIFMMLFSVENRSSLESIEGRWLPEIRHHMPDTPILLVATKIDLRGSSQHDYITFEEGFNLAQKHNLAYTETSAVLNTNGKDHAEQPIGCCSEPLTPNHEEVDVFHLYFSVRSKSSLANVESRWIPEIRHAMPDIPILLVATKIDDPWSAHRRRIVSYDEGLKVAKKHNVGYTEMTGLLNMNLKDCFEKAVYIADEASKPLKKRGFGFFGFGKRKQKARPPEKPPLDEAPRIEIQTSTIAEDLGKALEQPSYSDVTFLVEGKSILAHKVVLCSASNFFCCVFGLRPPDQDTGSSSKVWNFTWEDINEGKIAGLAGILDVVTPDSSSCDKPTTQVTISEDISYKTFHHVLEFLYTGLPNIPEGASAEDIVALQMASSTFCLPMLDSIIKNLQNVAEFLNPSIRTFLNDQTGQRAKQLFLNSQELSDIRFRVEDQTFFAHKILLTSRCEIMARMFSGVFTESNKEEIRIEDVSPECFLALLEYLYTDHAPIEEGDAVGIMVAADRYGQERLKNLCELYITKGVDVAVADCIEEAHVDVIGLLHTAQMHNATQLAAWCLHFISSNFMAFKQRAEFKTLEGENLKYISENRWPPVSYLEELEKYNAKYGQKEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLV6</accession>
    <name>A0A914BLV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077099.1">
        <property type="nucleotide sequence ID" value="XM_038221171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221171.1">
        <property type="protein sequence ID" value="XP_038077099.1"/>
        <property type="gene ID" value="LOC119744948"/>
    </dbReference>
    <dbReference type="GeneID" id="119744948"/>
    <dbReference type="OMA" id="ACHARHV"/>
    <dbReference type="OrthoDB" id="9998363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19192">
        <property type="entry name" value="PR-SET_PRDM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044402">
        <property type="entry name" value="PRDM8-like_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="183" mass="19936" checksum="D6C79088CB34F947" modified="2023-02-22" version="1">MIESGPGLSVVVVAAAAAATTALRGMFPAVDLPHASPMLGRAGSVTTKSSDIETSVWTSTEIPADVSFGPFDGEFRLGAAMKDSRDSPYMLEVKYSEGRLVSGPDSHPTRWMRFVAAAHDEHEQNLSAVRSPEGRVMFRTTRSILRGEELLVWYTSAFAEYLGMPTTVNQYRGKKHCIVLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BME8</accession>
    <name>A0A914BME8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD164 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076926.1">
        <property type="nucleotide sequence ID" value="XM_038220998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BME8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220998.1">
        <property type="protein sequence ID" value="XP_038076926.1"/>
        <property type="gene ID" value="LOC119744834"/>
    </dbReference>
    <dbReference type="GeneID" id="119744834"/>
    <dbReference type="OMA" id="CQNDVAT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007947">
        <property type="entry name" value="CD164_MGC24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337">
        <property type="entry name" value="MUCIN/PORIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337:SF8">
        <property type="entry name" value="VISGUN, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05283">
        <property type="entry name" value="MGC-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036815129" evidence="10">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="16499" checksum="2AF8590D46169D08" modified="2023-02-22" version="1">MDTRVLLLVALAAFISTAGAPPTGTPDTVGPDDVTTKTAVTEGPAIVTTQGAVTTKPPTTPAGKTSPTPNPTTAPTLAPTEATETKQPATLAPTAGKATKTPSTDSGPTKPVGPTVKPTPAPSKGGFDAASFIGGIVLGIAIVLIIGFGYSFYKTRRDKNYHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNA0</accession>
    <name>A0A914BNA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077430.1">
        <property type="nucleotide sequence ID" value="XM_038221502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221502.1">
        <property type="protein sequence ID" value="XP_038077430.1"/>
        <property type="gene ID" value="LOC119745266"/>
    </dbReference>
    <dbReference type="GeneID" id="119745266"/>
    <dbReference type="OrthoDB" id="6139560at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037517969" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="279" mass="28591" checksum="99E4B893A7E1E385" modified="2023-02-22" version="1">MKICVATILSIALLLGNSVKLRASVTGPVPSDGDGHASQVCQQCCQGPAAIPGIPGLPGPVGPIGPYGQPGSKGDKGELGHKGEIGQIGPVGERGAAGNNGSKGDGGIGLPGKVGPRGTPGLVGATGKSGVKGQKGEPGESPADSNLRVAFTVVRTSSSVTSSSHDTRLPFQQTTTLLSGTTFDLETGTFTCSVPGTYAFTFSVCKYHSTSDLWVHLRENSDWVVTAHGDHASDNDQLSGSAVLVLQRGDTVYLTMQGKAWSHPTFRSASFSGFLLYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQQ5</accession>
    <name>A0A914BQQ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="RefSeq" id="XP_038078637.1">
        <property type="nucleotide sequence ID" value="XM_038222709.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078638.1">
        <property type="nucleotide sequence ID" value="XM_038222710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222709.1">
        <property type="protein sequence ID" value="XP_038078637.1"/>
        <property type="gene ID" value="LOC119745976"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222710.1">
        <property type="protein sequence ID" value="XP_038078638.1"/>
        <property type="gene ID" value="LOC119745976"/>
    </dbReference>
    <dbReference type="GeneID" id="119745976"/>
    <dbReference type="OMA" id="MFYNDVE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioesterase" evidence="27">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="19675" checksum="FCC568E62CCF7E83" modified="2023-02-22" version="1">MTSSSKSHWDWLPETEELFSKLEAEPGWSQMRSTKTDKQMKYLYSRVVTENGPVIHFALFLHDKDGKLRGLCQFGEDANGLIKGAVHGGAIATMHDTTTGVLATDLGKKKMYTGYLNTTFKRPTPVRSAVLMEAVIDKVEGNKTFLKGYLKSPDEQVVYSECTALYITAEKPSGSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRT1</accession>
    <name>A0A914BRT1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNAL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A914BRT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222398.1">
        <property type="protein sequence ID" value="XP_038078326.1"/>
        <property type="gene ID" value="LOC119745793"/>
    </dbReference>
    <dbReference type="OMA" id="MKTQGKY"/>
    <dbReference type="OrthoDB" id="191529at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000048">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000434">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="306"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="568" mass="63759" checksum="C42C755DF8C8CFCA" modified="2023-02-22" version="1">MESLSYGAIKTANHAREADEQKNEQRKRNLLILVLHHLVQEGYTEAAKSLEHESNLSFSRFEVCDNVDLETILMEYESYYYVKFQRYPKVTKKICTDGNSPQKGTKKFVRNGSTPTLPRIPHPQAPDPKDGPASAPSHLGRRRPNSSTATPNRKPAIDRRPSRETKQTSQVNGVGDPLSDLSVSGSTVANRSSETNLANGSGKLPPKKGPIIDMRAMLNNAIKGATQEYIGDNNPSDRLLKPLGGYSGYTLEWRELAQSISKDIYLHNPNVRWDDIIGLDSAKRLVKEAVVYPIKYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECNTTFFNISASSIVSKWRGDSEKLVRVLFELARFHAPSTIFLDELESVMSQRGSTPGGEHEGSRRMKTELLVQMDGLSKSDDLVFLLAASNLPWELDHAMLRRLEKRILVDLPVLEARRKMIEFHLPEVINPDCALEIKTDIDYEYLAQLTEGYSGSDLRLVCKEAAMRPVRKIFDILESSTVDNTDNNLYWKKEKVPEFSIDPISTDDVIAALAHTKPSAKLLKDKYIKWQKEYESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXP4</accession>
    <name>A0A913YXP4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ELK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044308.1">
        <property type="nucleotide sequence ID" value="XM_038188380.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188380.1">
        <property type="protein sequence ID" value="XP_038044308.1"/>
        <property type="gene ID" value="LOC119719076"/>
    </dbReference>
    <dbReference type="GeneID" id="119719076"/>
    <dbReference type="OMA" id="WESERRA"/>
    <dbReference type="OrthoDB" id="2020852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF2">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="1802"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="1832"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2109"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2180"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2214"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2383"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2491"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2598"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="2734"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="8">
        <location>
            <begin position="3776"/>
            <end position="3797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2047"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2874"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3282"/>
            <end position="3319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3680"/>
            <end position="3701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3900"/>
            <end position="3923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4477"/>
            <end position="4502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4516"/>
            <end position="4574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4873"/>
            <end position="4902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4951"/>
            <end position="5001"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="230"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="364"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="613"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="783"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1767"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2115"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2306"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2449"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2604"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3379"/>
            <end position="3573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3637"/>
            <end position="3678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3767"/>
            <end position="3798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3976"/>
            <end position="4003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4142"/>
            <end position="4197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4251"/>
            <end position="4299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4579"/>
            <end position="4632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4674"/>
            <end position="4758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2047"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2884"/>
            <end position="2899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2905"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3686"/>
            <end position="3697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4516"/>
            <end position="4526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4532"/>
            <end position="4541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4874"/>
            <end position="4902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4977"/>
            <end position="4989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="5034" mass="581740" checksum="E22134378420436C" modified="2023-02-22" version="1">[encoded data, 5034 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXT6</accession>
    <name>A0A913YXT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044569.1">
        <property type="nucleotide sequence ID" value="XM_038188641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188641.1">
        <property type="protein sequence ID" value="XP_038044569.1"/>
        <property type="gene ID" value="LOC119719260"/>
    </dbReference>
    <dbReference type="GeneID" id="119719260"/>
    <dbReference type="OMA" id="XEEEANE"/>
    <dbReference type="OrthoDB" id="5837849at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="29147" checksum="EE2CF182541A90BF" modified="2023-02-22" version="1">MDLKKLKIPELKKELTSRGLALKGNKQELVSRLSEYLEENDESILDNGTEPTDAILTPGVEEDLSEPEDEPSLLDDEEEEEEPEAAVVPATVVKVSSPVALQRMPIVVAPEEAKPTAPAVTAQKIAIAAPTATVLTPAQKKALRAERFNTPLSEDAKKQARLEKFGGKLAGTASAGAVPKTQGSVSTMSSDALEKLKKRSERFGTAVSPVVKKTDEMDRLLKRKQRFGVITNTTTANVTATATGNRRISTEGATGDTEAKKKKRAERFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXW9</accession>
    <name>A0A913YXW9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044212.1">
        <property type="nucleotide sequence ID" value="XM_038188284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188284.1">
        <property type="protein sequence ID" value="XP_038044212.1"/>
        <property type="gene ID" value="LOC119718863"/>
    </dbReference>
    <dbReference type="GeneID" id="119718863"/>
    <dbReference type="OMA" id="KVDVTHE"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="45272" checksum="F591940BB93B5413" modified="2023-02-22" version="1">MLMSTNEMFRVPKMALYWLVVLVGELLIRVIISPLFRLCVAVENLEKNNHQSYVLYNLTDPSNTTMAKVAQPRPQTTRVLLWAPPRSLSTAFERCISALGDRVQVCHELYTAACHLGPENQIKIPVLESVVRDPHYTYAWVQKIMEARAPPKKEIFFCKELAYSVEGKFDKLPAGYRHTFLIRHPARVFLSMNTLVKRYFARTFLDLKLSQVLPKGLVYKEMFDLFEHVTNDLGQEPIIIDADDLLQDPLGVLCAYCNAVGIPFSPSMNKWRPIKEEKRTWIYSTRLMIINKIIGQYDRAFRTAGLERHVEKPIDLSRVTPEVLEATKASIGYYEKMYALRLKTRTPNPYVHVKPSPNPAVPNGVPSMSNGSPPQTNNQCVSVPFTKVALYTVANVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2V1</accession>
    <name>A0A913Z2V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046037.1">
        <property type="nucleotide sequence ID" value="XM_038190109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190109.1">
        <property type="protein sequence ID" value="XP_038046037.1"/>
        <property type="gene ID" value="LOC119720446"/>
    </dbReference>
    <dbReference type="GeneID" id="119720446"/>
    <dbReference type="OMA" id="PSRGVYC"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22183">
        <property type="entry name" value="F-box_FBXW1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056829">
        <property type="entry name" value="Beta-prop_TEP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25047">
        <property type="entry name" value="Beta-prop_TEP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="328"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="513" mass="59025" checksum="A590186183648945" modified="2023-02-22" version="1">MEISTMNEDSELISELPEGTTIPVRSLSRNKEPSPNYEGEKETCLKYFDLWKENEQLEFVEHLIAHMCHYQHGQLNSYLKPMLQRDFISALPKKGLDHIGDKILSYLDAKSLCAAELVCKEWKRVISDGMLWKKLIEHKVRTDELWRGLSDRRGWGHYLFKPKPGETPQSDIYFRKLYPRIIQDIENIENNWRCGQHELFKIQCHSENSKGVYCLQYDDQKIVSGLRDNTIKIWDRQTLQCIQVLTGHTGSVLCLQYDDKVIITGSSDSTVRVWDVNNGQMLNTLIHHCEAVLHLRFSNGLMVTCSKDRSIAVWDMRSATEINLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHRRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRATSGTLCLRTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNVPSTESLSGSGKSPSRSYTYVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3M9</accession>
    <name>A0A913Z3M9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Caspase-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046409.1">
        <property type="nucleotide sequence ID" value="XM_038190481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3M9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190481.1">
        <property type="protein sequence ID" value="XP_038046409.1"/>
        <property type="gene ID" value="LOC119720684"/>
    </dbReference>
    <dbReference type="GeneID" id="119720684"/>
    <dbReference type="OMA" id="GYTPICH"/>
    <dbReference type="OrthoDB" id="6114029at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31560" checksum="3AAD02FD3E20688E" modified="2023-02-22" version="1">MKTAQPTPDMLNPQLTYQLTSKCKGLAFILNNIDFNQSDRREGSQIDLANMEHLFKELGYTPICHKNLKGEDITKYFKEFASMFNHTGVSYDSAVIALMSHGDTGVILGTDNIQVKLRDLQGELEPHKCPGLDGKPKMFFVQACRGRFVTTLPVSHDGPNTASGAQESNHPLEELVPEELATFIADIGNPADVHFAYATTDGYLALGNEVIGSFFVQALCEVFFARAHLDNLDTLMNEVTRKVDSMTGLLYDQELQRNVYVKQTPQCVKTMLKAFYFFPNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3S3</accession>
    <name>A0A913Z3S3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046449.1">
        <property type="nucleotide sequence ID" value="XM_038190521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190521.1">
        <property type="protein sequence ID" value="XP_038046449.1"/>
        <property type="gene ID" value="LOC119720713"/>
    </dbReference>
    <dbReference type="GeneID" id="119720713"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20141">
        <property type="entry name" value="PWWP_MBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF16">
        <property type="entry name" value="SIX-BANDED, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="2817"/>
            <end position="2876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2325"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2388"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2524"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2609"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2875"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2910"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1680"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1982"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2117"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2153"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2325"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2351"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2403"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2530"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2653"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2724"/>
            <end position="2744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2928"/>
            <end position="2938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2938" mass="325163" checksum="59D939B3ED2520C2" modified="2023-02-22" version="1">MNPERQIYMNAAMAGSDQGLGYTTVPMGWNRTIWGDGSVVYVSPSGHLLHCAEDLQRYLLAEGTCKCGLECPLIIDRVFNFNPRVPARPKLPSDVLVGSQLNALCKHRNKLVAMAIGLQGNEETLANIGPPGGVSVFGRSKGSKRSRSKSKPERAVDFQPQNLSASQVLALQGGHVHQIPGFANFMPSLKSVPFEHQLQQHSIESQQRQIQMHLLQMQHQDLMQQHQQMQHQLHHQHRQTPMQRRSQEVESLHSPVEQYSLEQRSGKRLHSSPPSSCPKRPPSNSGSAGSQSAPTSASPHSTTPRCSKSPRLSSELTSPSSKERQPLHGHSLLPLPFHGETHQLIVDGQTLAIHPDACAPSVIPLLSNMYHAQNRASLNAANVSNSQALFANHNDEVFFMQDGSRKGPSRTVHDSVEVPTCQAEDTNKLESKSPVRNLKDNTPSPIINKPVTMHSTKPDKKPTVGNMTLQQIFKQSLEGSAFPASSLLSAAARAQLAKQPQSPDSPSPHHAGDLMSGMGLFNKMSSNLTSKDTKLELAALPSNKGSQFSASRKHVAKSTNIDVVHSSEMNVKGTASAPQQTDESPIQCLENAVQNLKDHPSTLKPAVSAVDVFSPEVTQDSSACRKRLSTDAEETMEKSVKRQRLQSSDSVGSQTKQSEAAMSTHQVPAINSDKPLSMHHHDTTKVTGSYNVVCSTGKATSSSKHPTAENAELARWQQQQQEWYANMLRVKQHHESGNMPVEHFPPGSQVRPPQIRSRGLQELQYIAMGGNPPPRMQTMQQHPHVGHMHRFPNHFTNPQFNPHQANMMHHIHRMQMPFRMDHPVDPLDPNIAQNPSMCNSNILQSMLQQQQQLQQLGMLPPGNFQHPVHHISPVHHLDPSQHIPVAQADVPSLPQAHVHGQDTTNPGAMPQHKKGAKPVRGASTSTSTALTCTVDIDDEEPKDAAYWVKAASKSGGVKKVKDILAMTRSLQKHNSEAGQVEAIFQAVLDSASGGMKVIIKEGTRSQEGVQSGSADNNQEKETDAPPKAAIESTDRSDSMCEVSEQSSVSPSPAQQNAVEPDFEVQDESSDDLLNADAVERPCGESLDQTSELDIPTSQDDFRKAQNLSELSVTQMESNPDTAILKTQDLESVSLDGDEIPCPTRSEGDHMASPIHDETELEPEGSSKVPHQDNVQVITCDKMYTEGHGLGSDEISEWVSPPVEDTCTVSDQVQSITSTDQPIEFPDSPQPAICQSTKLSGEHKRKSTDIKDSKSDDDELQEHVSLSFDLSEDESKVQSDVKDGEEDPPQDQLLEHAGEVRTVLNEHGCSVHEIEPNANYPENPTSDTIGKMDMEDISDGSYDMASLDEENTDPPQTDQRETVVDQVKEVQSTGGQSHTCELKGNVGTHPPLVAGGKDSSDVIVDLLKEEKSPHTSSSLPPSDPQVDTAKSSVKDQRVDETAVKFSQEITSVQHSNDTGNDITVLVSGDMVAGSDMDYTGEVMESKELNSSPDTEVERQGKPVTVQEHEQMDTDAPVVSQIVQQEQALDFQPIDSNIKHHVVMDNQPLDSTVDSEVIQNNPLAGNIPIEQDAINHNQLVDQDSMLGSKVSAQKQQVEGKPGSSEPVIQADQQDAARDSEVVTQGQSIDSESMKQDPNEDDLPRKQDSTEEDLSMTQVPTEDGLPMNQDPTEEDLPMKQDLTEEDLSMNQDPNEDDLPMKQDLTAEDLSMKQDPNEDDLPMKQDLTAEDLSMNQDPNEDDLSMKQDSTEEDLSVTQFPTEDGLPMIQDPSEQVLPMKQDLTEEDLPMKQDPNGDLPMKPDSTEDLPMKQDPTEEDLPMKQVPTEKDLPMKQDTNEEDLPLKQDPIEGELSLKQDPIEGELSMKQDSTEDELPTCMTKDPTEEDLPMKQDPTEEDQPMKRDPNEGDISMKQDPTEGDISMEQDSSEYDLPINQNPDEDDQLMTQNLNADQPIKQDSNEDDLPIPMTLDPTEDNLPIKQDTDEEDLPMKQDLTEDDHPIKQDSNDDQPTKHVPTEEDQPIKKDPIEDEQSVSKDSNKNDLPMKQDTNEGQPMKLNLTEDDWPIKHGSNEDDQPMKQDPTEEDQPMKRDSNEEDEPVKQDPIKEHQQMRKNSNEEHQPMKQDPTTSLDSEQQMDTEPVQQDLENVNHPVTQDPVVDNEQVQQDKPVNQDNKMDDNTMDFGSQPMDIQPVKQFQCLDNEPLEQDHTVADEEVEHDLSVSKGAVEQMHQMDFDQVKQDQDSSVESEPVTQDQLSELMKEVASTEESVKQCHSDNSESLRLDHLENLEIEEKFADRKTVKQHVVDICDNGSSKISEAVYVDLVTSSSFKQDHVVKHESDEQEKLTSVDHGTTDEVHVGSNEQFTQQDTDMPDDTEKSEPVKKDCFAHINLMGQDAQKTTELKVQSLPGKAETSKQSEDPHNQTVDCEPVFGDQLIDGEALKEDKTELVQEDNVDKSLVCMRPDSSREDRDLRPSQVIEVTTCINKTLSSDQDEESPDKSSSNMSLAKLENTLSYSNNPFDGLHTVETQSLETQDADLASERTPEQDHIPSGALLGIQNVPESECFMPPEGDSHHPAADSEAEESTVPDTQCPSEGLEHNLPVCSSVQRLTEKSTLVQANISSEAPLENLASSESRSESSPVIVNGPPYVNVDPPGEEPAPETTSQTEMTAASGQHSLSETPKESPSPQGSTQHRESPTPNGVLESEHLNDIPMDSAVVENQPDKLTYQGTSKGEKQSTSDDERENRENKPLTDEPPVQEICTVKRESNLKRGVSDTQKAVLSAKEAGLKKERLVQEAPTRVLRGNVRADPSTDLTASMFPRHLEIGDLVWGPIRGYPSWPGKLVSETEVRGRSRREEGKMWVRWFGDHSCSQVEPEKLKTLSEGLEAHHSARQSYRSRGRRMNSTLEAAIQEAMNELDKKMEQAKGTKSKSVPKSSRPKTRCKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5F2</accession>
    <name>A0A913Z5F2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein-signaling modulator 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPSM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046236.1">
        <property type="nucleotide sequence ID" value="XM_038190308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5F2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190308.1">
        <property type="protein sequence ID" value="XP_038046236.1"/>
        <property type="gene ID" value="LOC119720583"/>
    </dbReference>
    <dbReference type="GeneID" id="119720583"/>
    <dbReference type="OMA" id="NQSVLGH"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000043">
        <property type="entry name" value="G-protein-signaling modulator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72261" checksum="4AF6F9AAF1408BC4" modified="2023-02-22" version="1">MRLELEEGRASTNAFKMDASCMELALEGERLCKAGNCKSGVQYFEAAVEVGTDDLRTLSAIYSQLGNAYFYLQDYTRALEYHRHDLTLACTLGDHIGEAKASGNLGNTLKVLGKFDEAIVCCQRHLDISRELGDRVGEGRALYNLGNVYHAKGKHAGRAGHQDPGDFPEEVIGCLQKAVEFYEMNLAIVKSLVDKAAQGRACGNLGNTHYLLGNFETAIGFHKERLSIAKEFGDKAAERRAYSNLGNACVFMGDFETAADYYKKTLHIARRLGDIAIEAQACYSLGNTFTLLRDYETAVDYHERHHRIAQKLKDRVGEGRACWSLGNAHTALQNHEKALHYATLHLQISREVGDKTGELTAQMNLADLRTVLGLDKDPCSQDGLLQNASKKTLKEKELNRQRRQSMERLELVTMTPDKNAAAATANGKPKQSAGAKFKRKGSNKEKLSRKSSNTSSTSSSSGESAACLRTENVNIQVSPQQRSSPEFMDDDDSFFDVLSRFQGKRMDEQRCSFNRMQDKQRERENDEDRDYPMKEELMNQIASFQRSRLNEQRSSICNLPGLKTNNEEVLGQLLQKGNQGVPDDDFFDMLMRCQGSRINDQRSEPPVLQPAPTVPDEDFFALIQRVQSKRMDAQRSDKGPQDQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5T2</accession>
    <name>A0A913Z5T2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Twinkle protein, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038047094.1">
        <property type="nucleotide sequence ID" value="XM_038191166.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038047103.1">
        <property type="nucleotide sequence ID" value="XM_038191175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5T2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191166.1">
        <property type="protein sequence ID" value="XP_038047094.1"/>
        <property type="gene ID" value="LOC119721211"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191175.1">
        <property type="protein sequence ID" value="XP_038047103.1"/>
        <property type="gene ID" value="LOC119721211"/>
    </dbReference>
    <dbReference type="GeneID" id="119721211"/>
    <dbReference type="CTD" id="56652"/>
    <dbReference type="OMA" id="ANTMFGL"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000845">
        <property type="entry name" value="Mitochondrial helicase twinkle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SF4 helicase" evidence="18">
        <location>
            <begin position="539"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="834" mass="93048" checksum="C4B3D03FA8B01A31" modified="2023-02-22" version="1">MPLSTRPSGAAQRWSSSGFARMQQLSRLKSSLSVLQPPCRKKLATWNQVAVTTFSGNQHTINFYPSTETVNTASYNDHSNVSCQCKICPQLKWQSFSSRLKCTRAGKSSTISPTETLLQATPSQASLQSCHRFGVLLSTFRGHCLLRCLSQSAISGSKSHPHISTGPKPWISSPGQGPTPHRLFSTSVPMRTTFNSVEEVQVPTVTDMKRHLKNAEIDFQTGYTCLTAPCPFCSGVVAGARSKDVKTMFINMTTGHCICQCTKARGSWQSLHDSLAVAQQQGCQDPSFLDDPAAATDEEAEVRGQGSGMTKVQEVWEGAVELSACKGAVIDRLRASMGMEQIATDTLERFNIRYSKKQRAFVLPLYGHGEQLQGVKVLEVKKVTEGSEVTETLYPRHNQNGLFGYHLIGSRDGEMVLVANVLDALAVHQMTGQTVLALPNGSASLQQELLPLLEQFHQITLWFGNDMRSWEAAKQFARKLNTKRCYFIRPLDCHPPALVALQQGLSLRSILKQAHPVSHKSIVSFRSLREEVLGELSHSEQVAGVKWRRFPTLNKLLKGHRRGELSVFTGPTGSGKTTFMAEYSLDLCTQGVNTLWGSFEIQNVRLAKVMLSQFAQLNLEKNLDKFDKWADKFEMLPLYFMTFHGQQTMKAVIEAMSHAVYVHDIEHVIVDNLQFMVGYSDKSFMMERFAMYDHIIAAFRKFATSNNCHVTVVIHPRKENAMEELQAASIFGSAKASQEADNVFILQDRRLTALRGRKYIQIVKNRFDGDLGIMPLHFNKETRTMSPPSKSRSKKAAGAKVARPGEADESEDSYELFEELMLVSRQEDELGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7R9</accession>
    <name>A0A913Z7R9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047777.1">
        <property type="nucleotide sequence ID" value="XM_038191849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7R9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191849.1">
        <property type="protein sequence ID" value="XP_038047777.1"/>
        <property type="gene ID" value="LOC119721908"/>
    </dbReference>
    <dbReference type="GeneID" id="119721908"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037701585" evidence="11">
        <location>
            <begin position="24"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="251"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="350"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="455"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="699"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="880" mass="98166" checksum="7DDCB01F54DE258F" modified="2023-02-22" version="1">MASIEKCMRMLAVLLTMATLALSQTSVNETGYDRTCFLPPSKRTSNEDQLLLFDFSLPPSTDALTEEAFDYLAFPTGTCGVELFFRNPHLYLSPELLPTIKNITTNFFPKFCTQHYVNSNQTSPLWRFDVITTGTQIFGVPSRPLVPDEELSRVPDSWLTSGGILIRITTDSLAAAGKLIIRCNAPYLFPVPDSIYNVNFTFEINGCPSGKYDSRCEKLCNCAEGVECHSFNGICMCPRGLRRIRCDQRDPELATNLTQGFISYGESSNLTCTTYGMSPSNWSWTKEGQTTPLETVTWEKLVPYSPRPTMLVTTIYAESTSANGGYVCEVRDENGTIYRQLVNVTVIAIPDPFIQVPENCTTLAGKNVTFTCQTKADAGRIKWVKGRNQTRCTGAEIKDKPGRYEILSSTGGVCQLCIYGVEFADEDVYSCCVGHAAAAQDLSYVEALLVVQSAPRADCSFQDIIDVRSGHLLTLWCILESAKPVPTLTWTVEGRQKALQPVSNTRLSGDDSPSNVNSSVTFEPAPEDDGKRISVTVVSPVVTGNQEVVAFLNVTYAPIVTISPDPLTLTTSQDAMVKCDAKSNPKPTTYTWTLRKKNKLISNSPSSNGPTYHFKTVRKKYDNASLTCVVRNSIGETEMSVLIKVVETRFSPGAIAGFSVAGGLFLAVLVLASCVAHRYRKDIKLWRAKRAGKDKVDEKEYDVFISYKSGSPDEEFVIHHLIPRLEQDGYRICVHYKSFLPGKSIIDNISDAVHRSRKTLLLLSPGFIESEWCRYEFKAALSQMLRLRTDLIPVIFEDLGPQENLFEDLQTILRRLTCIMWPNDPTRDQYQTDEDRQQFWKLLGQALPDNPLDREGPGHDHHPEREEHVCETSLGMNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8V6</accession>
    <name>A0A913Z8V6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antistasin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048223.1">
        <property type="nucleotide sequence ID" value="XM_038192295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8V6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192295.1">
        <property type="protein sequence ID" value="XP_038048223.1"/>
        <property type="gene ID" value="LOC119722255"/>
    </dbReference>
    <dbReference type="GeneID" id="119722255"/>
    <dbReference type="OrthoDB" id="10037294at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037317903" description="Antistasin-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="376" mass="39927" checksum="462D2523D319D7BB" modified="2023-02-22" version="1">MKGVAVFCFLLAVLGCKFGAEASQGGRAERLRQAEEVPDFSCANWHSYSDADFGAMATAGIIGAYGRKCHIFQGSSKSACNWYVKYDDDGDTMDNWKGLTFGGVPGGSGCCASISGCSTLNGAGAWLKSHHEEYCCGCPELDCEPCPAGYVIDENGCQTCTCAFSCHHWEDYSVEQFAEFAQSPDVIGEHGRQCTIITSHNTACDHYVKYKDQGPNWLGLTFGGNPGGSGCCASISDCQTLHGAASWMKAKYRDYCCVPEFTCENWDSYSDHDFGAMATAGIIGENGRKCRIAQGGSKSACNWYVKYDTDGDTADNWKGLTFGGVPGGSGCCASVSGCSTLDGAGAWLKSHHRNICCGPTVGAAHRRALGRALGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8Y8</accession>
    <name>A0A913Z8Y8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048212.1">
        <property type="nucleotide sequence ID" value="XM_038192284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8Y8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192284.1">
        <property type="protein sequence ID" value="XP_038048212.1"/>
        <property type="gene ID" value="LOC119722238"/>
    </dbReference>
    <dbReference type="GeneID" id="119722238"/>
    <dbReference type="OMA" id="ESRSAYW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="139" mass="15120" checksum="9DDDE3A4B058F01C" modified="2023-02-22" version="1">MVGFQPTEIPPTLGMKFISAGLAACIADAGTFPLDTAKVRLQIQGESSSAQKQGFSFSKAKEEKAKFKYRGIFGTITTIIRQEGPRSLYNGLVPGLQRQMCFASVRIGLYDSVKQLYTGRHFGNSGGFILVLVLCHHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8Z1</accession>
    <name>A0A913Z8Z1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Target of rapamycin complex subunit lst8</fullName>
            <shortName evidence="11">TORC subunit lst8</shortName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of TORC1 complex. Part of the TORC2 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048253.1">
        <property type="nucleotide sequence ID" value="XM_038192325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8Z1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192325.1">
        <property type="protein sequence ID" value="XP_038048253.1"/>
        <property type="gene ID" value="LOC119722282"/>
    </dbReference>
    <dbReference type="GeneID" id="119722282"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000086">
        <property type="entry name" value="target of rapamycin complex subunit LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="318" mass="35408" checksum="00449DCF261FE121" modified="2023-02-22" version="1">MANPNDAGDRQVILATAGYDHTIRFWQAHTGICHRTVQHQDSQVNCLEITPDKHLLAAAGYQHIRMYDINSNEASPVINYEGISRNVTAVGFQEDGKWMFTGGEDCTAKIWDLRMRNLQCQKIFQVNAPVNCACLHPNQGELIVGDQSGTVHIWDLRSGHNEQLVPEPDSSIQHLSIDSEATHMAAINNKGNCYIWRVSPGKEDPISQLLPKTKIPAHKKYGIKCKFSPDCTLLATTAADQTVKIWKTADFSLLTTLTDAVQRWVWDCAFSSDSLYLVTASSDHTARLWSVEQAEVKREFNGHQKAITALAFSDGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZA19</accession>
    <name>A0A913ZA19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048623.1">
        <property type="nucleotide sequence ID" value="XM_038192695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZA19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192695.1">
        <property type="protein sequence ID" value="XP_038048623.1"/>
        <property type="gene ID" value="LOC119722523"/>
    </dbReference>
    <dbReference type="GeneID" id="119722523"/>
    <dbReference type="OMA" id="IGAYKRS"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="407" mass="44884" checksum="DDD73F710C6C4667" modified="2023-02-22" version="1">MATVKSWIGSERHRERVGDLLSTLDVPSLKGKKVLVTGGGGFFGIHLARALHMLGCAVVITDKGTPIEDYSKDITFVQGDIRDRDLVEELCKDVNCVFHIASFGMSGAEMMKKRDFIESINVGGTENVIEACIKQNVARLVYTSTINVVLGSKAFDMATEAELPRIPPEEHADDYSRTKSIAEVLVLKSNGRQTQNGEILHTCAIRPPGIYGAGEQRHFSRIVGILKIYKANLGSPDSKTNWVHVDNLVNGHLLAADGLSAGKNHISANQAYFITDETPINNCLFFKPIITGLGYTFPDAWLPLGVLYCLAFLSEIVHFLVKPFYNFVGFTRTEMFQAALHHTVSYEKAQDQLGYQPLQRGLEDSLAHLRQLGYGKDPETSSSWTSSLLFKIVLSITIIIVLVAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZAT2</accession>
    <name>A0A913ZAT2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048887.1">
        <property type="nucleotide sequence ID" value="XM_038192959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZAT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192959.1">
        <property type="protein sequence ID" value="XP_038048887.1"/>
        <property type="gene ID" value="LOC119722706"/>
    </dbReference>
    <dbReference type="GeneID" id="119722706"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="101" mass="11403" checksum="9B1AF61DF31E120D" modified="2023-02-22" version="1">MEEYVWDSVHRSVMTALARMKSKDNIGGDLSPGEELDYLRSPEVSGYRDAVTALRNTKESHESRSLERYKAAALNLLQMSSREEAQTLRVTARFPVRDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBB1</accession>
    <name>A0A913ZBB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RabBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049072.1">
        <property type="nucleotide sequence ID" value="XM_038193144.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049073.1">
        <property type="nucleotide sequence ID" value="XM_038193145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049074.1">
        <property type="nucleotide sequence ID" value="XM_038193146.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193144.1">
        <property type="protein sequence ID" value="XP_038049072.1"/>
        <property type="gene ID" value="LOC119722801"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193145.1">
        <property type="protein sequence ID" value="XP_038049073.1"/>
        <property type="gene ID" value="LOC119722801"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193146.1">
        <property type="protein sequence ID" value="XP_038049074.1"/>
        <property type="gene ID" value="LOC119722801"/>
    </dbReference>
    <dbReference type="GeneID" id="119722801"/>
    <dbReference type="OMA" id="FICKNCR"/>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000018">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051745">
        <property type="entry name" value="Intracell_Transport_Effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555:SF3">
        <property type="entry name" value="RABBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RabBD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1369"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1688" mass="186475" checksum="332550D0DE6BE74E" modified="2023-02-22" version="1">MGRKLNLAHLSEGECRQILDVIQRDYSIRQKEKERLVKLQKLVKDEEQKRLVLSRQKQFNEKYCICCFSSFGLIFNKRAECKSCGFFVCRDCSVKPEGHKESMCLGCDQQRELQVQVCEWFYGQIRNRFRRFGSAKVVRSLYKKDSQSSDSVDHSSNDSGVDHGHQLSPPAREALNEQASKAFQDTLEKQTSTEHAQLCKLSQGWFSSMQTPRAHSGKAVKDPDWLPLFKPETMSVAVQAPEDVLSDVLDSRQALEDFVFNLPPEEEELGRRLEKKPARRHSGPEVVILDPDGEPLSKAQDSNRKVHFGEIPPPAKSKDTSLVSAGAAYHVLSPIEEVLSSPEIVDKYSDSNGNNLARSASPLKDRGSIDRLSLGDDDKRARADSSSSISPHDWDSGIHMPLCLTQDGGWEVSQSTSSGTDSTDGSQVRDPAAKLGSPLQNFKSDSVDSFTSMSLPSLDANDTLDSLETHYNSIHSDTNTPEVTDEYVSSSSTLVENQSVNEDNDDGVNYVGIEIEQLTLSRSSSEETLKTDDEDDLDGKVGDLTMEEFLHQLTHLSLSEISEDAEDLNQDAGEILDVQDASPSLTEETSLASSNEDSKQDEIGSLSQRMKIAEEIQPLLAEEEEDSELAKNVSVDTLVLEAQQKEERCQDSLKVEPKKQAESEEKHFKCTKSHHHHSSRSHVHDSTARGKNPYKRSKSNDDFILSGRSGDGRSKSNGSKSHRRDGEPAMKCTKESHHHGKHHERSPSNRFIRYDSLPLVVEVFEAEGSYHWHHSHRDFRQFSRESDSNDSEPSNQVASKTSRSGAKLVRAAHLSPKSSYEEDPSQSRQLSIESTTTEDTMPKSTSQSSGPTTPESRRDSQQLAGMSSEDSSREEQCSPDKPLHYSPTEQSSGLQSRLSLSQPKPTSLDYGGKERNIQETIASLQSSTQGENTLISSGNAKKDEQTVGCHPDRSTIQGKFLGSASSSDSQTSQKTSKELQSPQLSPRAMPNQASPLTSPSQLHSLESLLRLSPSTPPTQLSPGGSPLTTPKRMASLRKDIQELANLSKKVSITQEEMLQSAEEVLTSAHKMSNIQTQVEELEDVLDSLERTVIGESSSLYGSSSSENEDSVVGPQEQVVEDMQLLEKQLASSHTDNAPSETNSATAVRMITATALKLLGTTEDAMESHSASLASPTPQTDASSRTKNTVSEGLGQETCGEKTPGETGEQEVGLRDSQSLSRGSSEEEEMCACSSTDGSRPSSLTLDDALTRNPCHSQNPGQQFDGGLESQTVPPKPEKSRNPTLHGVAFLHLHPGQDSPPIATLMCEMEENVRNGNGISAAGSPFKNGDSTMLDEAACKQTSPRSLSVDSCSDLAFDLEGSFDKDKAAERRRRKERKLRKSSGYNASPTREQEIDSLLYNQMADLEEKVYLSAGKVFTLEERLQQLQERVSQVDRTSPEENIVDLEDKIALTMAQVAQSENQVRAVEAQIEALQRSRESTMDISQFSTVSVAMCDLASPERYNPYAYRYGSSVQIQIPRERVDSPEDFVMEVSQPNPEYNNNKDGMEVEREEVELEMGITSDEGVAVNGGQTEPFGVERCAVSLELRPINAVIVRYLQEGDDDSLWPDFRFHRNKPRLKHAGEKKLKLDEDVANGHHSNELNSEGNERHISTLELSLDYPDEPVATPDGQPEVSVSIPVNEIEEILQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZE91</accession>
    <name>A0A913ZE91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylglutaconyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049376.1">
        <property type="nucleotide sequence ID" value="XM_038193448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZE91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193448.1">
        <property type="protein sequence ID" value="XP_038049376.1"/>
        <property type="gene ID" value="LOC119722998"/>
    </dbReference>
    <dbReference type="GeneID" id="119722998"/>
    <dbReference type="CTD" id="549"/>
    <dbReference type="OMA" id="YEQAHAW"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000022">
        <property type="entry name" value="methylglutaconyl-CoA hydratase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33081" checksum="ABE95285241938A2" modified="2023-02-22" version="1">MARFVRRSARSLLYFNKTENGVKHLPVFGRCFASSGGDSPDDLRVRYLEGEYLGVVVLAFNRPEAKNSFSRNILELLKDAVSTITYDKNARVVILKSDVPGIFSAGADLKERVKMKPSEVGPFVSSARRLISDIGDMPMPVIAALDGVALGGGLELALSCDFRLAASTAKMGLVETRLAIIPGGGGTQRLARLINPAKAKELIFTARVFDGAEAERLGVVNRAVEQNEKGEAAYEAALELAKEIIPQGPVAVRMAKKAINRGLEVDLASGLEYEMAYYAQVIPTKDRAEGLTAFREKRTPNYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGY0</accession>
    <name>A0A913ZGY0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050306.1">
        <property type="nucleotide sequence ID" value="XM_038194378.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194378.1">
        <property type="protein sequence ID" value="XP_038050306.1"/>
        <property type="gene ID" value="LOC119723629"/>
    </dbReference>
    <dbReference type="GeneID" id="119723629"/>
    <dbReference type="CTD" id="11234"/>
    <dbReference type="OMA" id="DSYLWSQ"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056445">
        <property type="entry name" value="TPR_HPS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23758">
        <property type="entry name" value="TPR_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="2">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HPS5 TPR" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1909" mass="210264" checksum="655366276653FE10" modified="2023-02-22" version="1">MAKPLTSGSGTTAHPDGFHILAELVSAEGLTSPIKASGRIKYTCIGVSKNYIGLGASSGSLYVFHRNTFKYLQVFSNTEGALTKVVFAPNDNMVGIATSQGVIITWELNIDRRVKSERLAMSSAHRNGVVTAMIWDTTSERLFSGDNHGRITFVNVYHRKMSGLFKLPTELVMDADSAIVQLDYCDDKLLASTTTKCFICDTKKKQAYAVGTKLRDGQFGACFLQKATKEFPLVYSARPSSRIWEGNIVGQVLATHQFKHLLTVPSLPVVGPGRSPIFPGADHTQKSQSLNFAQLLTFGHGHNLLLTWTTRAIYVFDPTHIKVMVWSMDFKDILWACVYKSRVYCLHPNSQVRCYTLLSAERCISRLFALSLWEQCAQAAVYFAERVKQGNARRYVPRSLIQEVNYQLMDGNADVALMGKMEELLSNMEEDGLSTPGSSRRSSLESSEGFRLDSGIYMVRNRAGSDDSVEDFPIQKIRPNVVDQETQMDDGMEGYDAKDDGKSDSKVNQDNAVNFLDTLNQKVAALALCEPLEEEKESEYVDQEHNFELNYDKDVATLSSGRAQALPSFQEEAAQDKTEMESFEDFDEEVEVDDSFVMEEAEEIEGPGDLASGPAGINWGISQGKLGLRRQSSLLEEIAEKSSEGQTNALVKEGELDTSIAESLNSSSDDPVINTLTDPKTDGRGDSQSSQGKTETSSHGNQGGLTNQCKADLGGTSSHDATTSSMTSSNGSSSQFDHSGTDNEQNHAPDSGRPTSNANSLTTQDRYSQLGQVIPMEADLSLKSFRNNEDPCSDKPLRPHNLPLEPASDIDLKSSSFSEGTEHALEDWPVVRRSISMPTADHMTSPDVDGRRPRKQSYSKDKKRSKKSRIIDFDKPQSPSKADEPPKTDSAFAAAVTPKDPSKQQARNPPTSTPTKRSQSLTPDPTLPQSPTSVPSKRTSQPEIPPHIQMDFLRSSSFSTEPMGGLGTFNSSEEMFLGGPSMMFSMAGPKLAAQFFAPSFSAVKESLSSKLVKTKTFLKQMSEPEIGNLPVDHPVTTETQAEVLALNSPQSPCKDPTSPQHSPPKDTLQRGLSHSFESEPSLSRSSLPKVTSVELQTSSNKPFDPEKEKVEYCNGLPDDAVVKKLALATWDTKHSLQDPKLSLSNRNCRDILEKWLHVLQNALASKNHHLQTESFEEAQETMPVDQQTGDQKEVTFHLESSGEDQSAPSVGEECPVLSNHSLTNKDLQVDKINEFERDALSLPVKSRSKSDSQLSDPFCLPAPVLEDVSKLAMLCFEMAVFDSDAIVQSDSPSDTERSGSYQDESSSPETDQSHPFLDPNMNTLHDNTSVTQSVIGSLHPNPNSPKFTDQSNALSHNAAQHNVPDCSSQGCVSMETEGIKLEEQDQKSANFVTSFFFLVDVERVREILKWRDGWRKLTMAAILDCLQARERKNETEIESISRLVQVIEDDTHRGKPANISHINRLIQHGQIETALDVMLGAFPDLVPWEVLHLTQADTAPPGCFLDYASALLESVEAMDRDTMLASICSDLEVKCHLLTSTLSQGAPAKAELFCTCGNMPRPGSHVLVWQYGTLTDQILSLPGTGRDRLLSVCIQHGYWPGVLRLYLQLHQRGQALKMAVQLADMKLLSKEGILPMNMDEWILLLNLMSQSQSVSNTIQCLSCNAMLLVKHNNHWLTTLATSQTSSDEVCDWSTQDSSSKPECDWGIDCKDSNQDGIKLPSDWLPSVTWESIGKLLVKSVGPGLATRMLTDTCIPCGELSKEFYKNCVLVGMLEKNEGNVCWSMLEGIDTYLWSKRNNTMAPSIYHQVLQERAQAMNNDGSGSETFNSKVPKPDAVSKSSCLFIEDNDCHWGTNVKLNSDCELCGLALSATVSARKSGLLAFPCGHTFHSACVVERACLLCYELKCQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHA5</accession>
    <name>A0A913ZHA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NXPE C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050441.1">
        <property type="nucleotide sequence ID" value="XM_038194513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194513.1">
        <property type="protein sequence ID" value="XP_038050441.1"/>
        <property type="gene ID" value="LOC119723713"/>
    </dbReference>
    <dbReference type="GeneID" id="119723713"/>
    <dbReference type="OMA" id="YSLICEN"/>
    <dbReference type="OrthoDB" id="2112051at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="3">
        <location>
            <begin position="338"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="64422" checksum="980284A918B48027" modified="2023-02-22" version="1">MAFFSATRRRVRCVQVFMVILAVAPFLCAVTAYMAGLDQHAFLSSLAVFRSTPAPTVVVQSEAGPIKIRPTSPPQHPTASANQHPTAGNLKVPDTVPAKVSPITVSLLSPRKDSIKVGDMIHYRITCRHQNGSLLSSGGGVWYAFLSSKSNPKASTAGRVVDHKNGSYSIYAYAGWAGTGTLTVTRALDNDAVDYMNNTIWPAEGRGVWKGIFQAPKGNTASSTCRLTRTGNLTGMCLYPRPNALGKTVFYCEKPEGVECDKLVSTKSDDRQMRRTLVILNREKAALVARTKTHLKVPIVLENPVVNISGPPSASTPVIQGCHTEQQISDGYWLENKWYSLICENKDWTEKSTLTSCLRNKQLLMYGDSTSRQWFHHTIDLLGEKFAPVPGEFGFHCFRHYDDIDLSILISFPKQLVGSRAVRLEGVFYEHDLIDALNDTRCNYILVVSPWAHFSFWSRDSYTERTLLLREALLRFRRRCPDAPIVVKGPHPRERVRSTVFSVDFMTRGIGEINRRVLGDIGAWYLPTWDINNAAPIGNGIHMPSFVVHEELKVFFSYVCGNSKMPPLDNRSPKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHJ9</accession>
    <name>A0A913ZHJ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050869.1">
        <property type="nucleotide sequence ID" value="XM_038194941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194941.1">
        <property type="protein sequence ID" value="XP_038050869.1"/>
        <property type="gene ID" value="LOC119724020"/>
    </dbReference>
    <dbReference type="GeneID" id="119724020"/>
    <dbReference type="OrthoDB" id="6107827at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="400" mass="44972" checksum="E481916F9C468FFE" modified="2023-02-22" version="1">MRKLLKDTGEELLQAGIEVALNFVLNDLGIPKEFLSDKEPCLAPTSMSHLQLIAALEERQLAITGTRMELEARLSQDDRSCQFSTLPVFPPELAKVAYCSLSENCLRLDCCLELNIKKLKFRRSFKAFVEVDACDFTFYIAFQHLQYKKLLLSYEWGKSQQQSIGPITLKYSINKLDAEKVFEVDFGASICQGADDCIFDVDIIQDYRVPIPFCNSNFSFALPGGNNLRDFLDQVGRNAGQEVVNVFLEFIGLRDKINDGQCDTGALVSVDEEGNGTVRGFLQMVGRNAADSAVDAILEHLGLSVSHFCQYMVIDKSDAEESFRINLGISICIDSECTTTSVLQDFLVPIPFCNLNASFELPGRRQLWQVLPGILPETLGSWPSRLVSKNLEYRYYFDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ14</accession>
    <name>A0A913ZJ14_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051787.1">
        <property type="nucleotide sequence ID" value="XM_038195859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051788.1">
        <property type="nucleotide sequence ID" value="XM_038195860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051789.1">
        <property type="nucleotide sequence ID" value="XM_038195861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ14"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195859.1">
        <property type="protein sequence ID" value="XP_038051787.1"/>
        <property type="gene ID" value="LOC119724691"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195860.1">
        <property type="protein sequence ID" value="XP_038051788.1"/>
        <property type="gene ID" value="LOC119724691"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195861.1">
        <property type="protein sequence ID" value="XP_038051789.1"/>
        <property type="gene ID" value="LOC119724691"/>
    </dbReference>
    <dbReference type="GeneID" id="119724691"/>
    <dbReference type="OMA" id="CEMQFAG"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="393" mass="39300" checksum="FAE028B9366E7E2C" modified="2023-02-22" version="1">MSRRSDEKMRKLFLGGLHRDTVDDDIKDYFSKFGTVEDQVVIRKPNGESKGFGFVTMSNMEETELVLNENSDGRQEMMGNSVEVKRAVPRESQGGRDGGGGGGRFRDSMSNKSVKKMYIGNLPMQMSEQNLEDFFSQHGTVTNVKIPTSRDTGERQKYAFVELEETHAVDKLVLQGDHEFNGLKFYVKKAMPQGDRDGRRGGGGGGGGRSYGGGGYGGGGSYGGGGYGGGGGGYGGGRGGSSYGGGSSGGFRRTGGRGGSSGGYGGSSGGGGGGGRYGGSSGGGYGGGGSYGGGSGSYGSDSYGSGGSSYDSFGSNYGQSTSSYGPMKSGGGGGRSNYGGSNNSAGGYGAGSYSNGSSGYSTGGSTGGYGSGGTGGYGSTGGSGGGGYRSNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJN8</accession>
    <name>A0A913ZJN8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051285.1">
        <property type="nucleotide sequence ID" value="XM_038195357.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195357.1">
        <property type="protein sequence ID" value="XP_038051285.1"/>
        <property type="gene ID" value="LOC119724346"/>
    </dbReference>
    <dbReference type="GeneID" id="119724346"/>
    <dbReference type="OMA" id="TFDQGMQ"/>
    <dbReference type="OrthoDB" id="6159341at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1298" mass="146070" checksum="CAA4C8E467A89666" modified="2023-02-22" version="1">MSYRGTKPLPGGQGRRAEADTPASLTPGSMLAPTVDYGEVNSLGFPIAISRQADIQEGLGDIASRLNRALGQYENVFDDDDEVSKDADWTVDGQADGRRMGARDEKREFQARYETITARVDAMERERTELMNSMAQWLEAEPVQWIPTADTGAITDDTPQKDGSIRDQLLKTKMGFEQLKQMNHEKERLDNQGQDTGHLQEASSNLQMKVITKFKKLYETKKLAATRRSFGTHWKHASEEIVGLLRRIRSEGTDNIDALEEQLEKAMNAIQRQSEEMMRLEGQIREKEEMVEKWSKDNVKLTNDNLLLNSEKEKCRDMIKKLKKALIEERRKKGKPTTEEDVENIAEGKAIKKQTPDIQQQTQRGFRRVAAGRDVKRDNVLCQICRRRVESGMRPERAAQDPVRSAETREGLGEGRGEGANEAITEDLVALQEENDWLAARVAHLEQKLIEKETQMMKLEFQLSEMMEAIQTSSPHIIQTLSLTDPTSLSSLVRVTRDTSQTGSTRQTEGNPSTEDSDGQGFSQKPTSGKKTSNLVVPRVIKPSSKKTVKRRAGEQQPITQPPSQSNLAQPAEISLLTEERNKLQEELVQVKGQLMRAQRELITLKYASSAPPVSMGTGGPRQGRAGTGERSSQEVSADSDNNLSTTKMQAETTTAQEKQAQHRAKPVVKYDDEFEAYAELISKDQVSRPSRRMSRPYPSQTEGGKQQGPVARVGEQKGGHEKQVPLQMEDYITFDQGMQTDPQMDPLGQWSNVPSLKKRKTDHQPILDTPSDQVPIAQPPTEWTHFDPTGPITPATDNKRASISLQMRAGQKPASLDTGGIVEYVDRELGRIIQGINGFTSYLKRLIQREVTDMITTNQDIRRRLSEVTLQKLDQGVKDSTHPSAETSRRSRALATPIHRGRFEVIKDHKPSKFATKNAFASLQSGGRKFYHSASPIPPWNIYSKTPTPLPADYMNMSTFAHDHITMADEVAMERYLASPHDTICSRLQHQIDMIGQHAIDVLKGTTVFFKETVTRQMEEYNTLHGAFSIRQELKTLMAPSTTPTESKDGTMESGNGETQADVTSDHAQLLYQDPPLKLARSTSHNSFLESRNIKYVQEKKHIDFDFQKHPKVYPLGTQSLSSMQSSHCYLPALALYDKQTPRNRYEMKVPKATLPRRGLVTLQVKEAAVKMDAKGVDTKRRSRPVAISHRGLQSHQREILAKQGTAQDRGEQDEEPRTTTLELKRQILQLQANQLYQAADQSSLPTGDPDTDARKTLPLLENERRRVIIHAQDQLRDTVQRWDKYAGLLSDGRGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJZ1</accession>
    <name>A0A913ZJZ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fission factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Tango11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052137.1">
        <property type="nucleotide sequence ID" value="XM_038196209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052138.1">
        <property type="nucleotide sequence ID" value="XM_038196210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196209.1">
        <property type="protein sequence ID" value="XP_038052137.1"/>
        <property type="gene ID" value="LOC119724906"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196210.1">
        <property type="protein sequence ID" value="XP_038052138.1"/>
        <property type="gene ID" value="LOC119724906"/>
    </dbReference>
    <dbReference type="GeneID" id="119724906"/>
    <dbReference type="OMA" id="FKTFMWL"/>
    <dbReference type="OrthoDB" id="5986838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039433">
        <property type="entry name" value="Mff-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008518">
        <property type="entry name" value="Mff/Tango-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501:SF6">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05644">
        <property type="entry name" value="Miff"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mff-like" evidence="11">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Mff-like" evidence="11">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="228" mass="25766" checksum="0607D256A5CA7F90" modified="2023-02-22" version="1">MGSTDTNSIINQMEQEMEDLQQMHYSTEYSTDINSKMQIPTRLSMGQPQDASFSDPDSPNMDYMTDSPAHAMNVPERIMVAGSDTHVGSRQTPRHLDLEEMTPFPTADTIVGLTTPPHTLKMEDVRFPTVGDQSVMKPDRSSMNHQRMTNGLDDTPTGPPKLLGNSSLVEGGPVLDIQGLQRHLHLLTRKVRTLEENSVRRDRRELIFCTVGVVYFVYKGLRFLYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL07</accession>
    <name>A0A913ZL07_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051731.1">
        <property type="nucleotide sequence ID" value="XM_038195803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZL07"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195803.1">
        <property type="protein sequence ID" value="XP_038051731.1"/>
        <property type="gene ID" value="LOC119724654"/>
    </dbReference>
    <dbReference type="GeneID" id="119724654"/>
    <dbReference type="CTD" id="6950"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="546" mass="59071" checksum="B9DB46AD6F80FA14" modified="2023-02-22" version="1">MSTSKMLSVFGERTSGDTVRHQNVTAASAVANIVKSSLGPVGLDKMLVDDVGDVTVTNDGATILKLLEVEHPAAKVLVELADLQDQEVGDGTTSVVIIAAELLKNADELVKQKIHPTTIISGYRLACKEACKYIQEHLTIGVEELGKDCIINAAKTSMSSKLIGRDSDFFANMIVDAVNAVKLTDPKGIVRYPIKAINVLKAHGRSAKESVLVNGYALNCMPASQAMVKRVTNVKIACLDFSLQKAKMHLGVHVIVEDPTKLDAIRQRESDITKERIQKIVGAGANVILTTGGIDDLCLKYFVEAGAMAVRRCKKQDLRRISKATGAQLLVTLANLEGEETFDATMLGQAEEVCVERVCDDELILIKGPKVRNAASIILRGANDFQCDEMERSMHDALCVVKRVLESKSVVPGGGAVEAALSIYLENLATSLSSREQLAIAEFANSLLVIPKTLAVNAAKDSVDLVAKLRAYHNTSQMQADRAELKWVGLDLVEGIVRDNKKAGVFEPGICKIKCLKFATEAAITILRIDDMIKLAPEEKEQMDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZL19</accession>
    <name>A0A913ZL19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Activating molecule in BECN1-regulated autophagy protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051785.1">
        <property type="nucleotide sequence ID" value="XM_038195857.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195857.1">
        <property type="protein sequence ID" value="XP_038051785.1"/>
        <property type="gene ID" value="LOC119724687"/>
    </dbReference>
    <dbReference type="GeneID" id="119724687"/>
    <dbReference type="OMA" id="TTECCQH"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1417"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1438" mass="158037" checksum="3D802B81502ED62B" modified="2023-02-22" version="1">MRGNWLATDVIKFQPYFVFFQGSEAGVRMVHQHKNVFLSLKGREIGFGGRIRRHILSHFAEEIAATSSTDNKACNLPGSRCTFLVTFSHDHKLVASSHGNHTLNISRLTTGEHIRTLTGHPRSPWCVTFHPSCNEILASGCLGGEVRVWDLQGRSEVWQSDNHSMIASLSFHPRDQVLAIATQDQILLWDWRQPVPFASVAISSPLEKVRLVRFSPLGHNLLTGIANAPVDEEEPEYENLDVQHEAYQSTTRHSRHGVPEHLNPYPRPPRLDPTLQGTYPSSLPSSQGFTAAARLRRPMSPIQNETLEEAREYAAAVTLTALGLRRVNPTRNLAHDYSYDGSRTGGQNLPNEQSDERESIFSRGARHASVIHSNAGTQNDSPEVRGENGGRSGISSWDLGESSDDTRGDMRSSDDAVSEDSQSTDRMSNVSIEESRNFSAPVYVNMDVTNGDEIRIARTSLSIPQTPNIDSGSHVARLQQLPMNADSGTSEELVSTSTKNAAASDQRSLAPGNELRPLDLVSSKKYGILPSTSSQHEQDSQNNETQSSSPSNSENKDCHSPEAKRHCPDLNSQDQTLSVKDTSQNNDEHSLSGPSSSSRGERSAKPGHSARQRLSFSDAEVSSVVQNVELLPRGDGESPVTETVASSHIVSSTSSQDTRLQSSDANSNSILTVQSSSSEAAATDSDTEMQPALQSQTLAHPRATVMHRDIGGIIDQPRAFTAHLGTIPHTAPPERTSDSDDTSTRRSTSHSSNDSHSLDISSEIHVDRISQSDTVSSTNTSSIASISLPTSSTNYANVVAEQTRPPQFGYQGGARALHFGSRSAINSGSNLNPLDLSIARSPTSSHTEVRSNIQDLPLGERHLESSGNSIQEAFRRRTSPEAPSQSSSANDHQSETRLVQDTRPNRESPVRSHYQTDFQPPVPQGIDLSIPHVRQGTRPPYAPVLTSTHTSGAGHMSHMSGSYMSRQQELASSSVPEPIPEPLTSLQPSNPFPVSDAASRYRRYNLWRSPGLHRQRTGGLTQNPDLRDGDSLMGDNQADEPRAGVVYGARRVAPLHTRRQPHLALFNQPSRQMTDIERMDMAARVQRRLLRQSRQGPLRAQLGRLTGQFSGQFSGHHHHPRNSIFDESYQPPPPMIHATINRAIASAFAGRGETAVANNIGNTTYRLQWWDFSEFELPDISDPDHNVIVPHCKIHNDASCDVSQDGRYLAAFVPSPLGFPDDGVLAIYSLMPHNFSDVLYTKSFGPNAITVNISPLSGFVIVGLASRRLHLHMASKQLMGMIYKLHKEGASEDSLLYVCDVDHTCSDQERRHHVSVNTVKWIPRPGGGLVYGTNRGDLRICSPANFTAPDDTSTDQSYRSDYTPLDDYPRHDLVHRRRSYTYMYQEFGLRNLGLHAPSSTAPSSGVRASAPERRARGTQTPQRALFSTATQTDEQEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLG1</accession>
    <name>A0A913ZLG1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arylamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038052617.1">
        <property type="nucleotide sequence ID" value="XM_038196689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLG1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196689.1">
        <property type="protein sequence ID" value="XP_038052617.1"/>
        <property type="gene ID" value="LOC119725308"/>
    </dbReference>
    <dbReference type="GeneID" id="119725308"/>
    <dbReference type="OMA" id="CHRRIPF"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="306" mass="35044" checksum="9B91432B2D1C841D" modified="2023-02-22" version="1">MSRSNDTISLIEAEDFLESILQLKFPMDRLTEDRAGFLRDVIASCHRRIPFQSVTSIATPKPERRALTFKEIKVDMMTRKGGLCCELNYFMKVLLETLGFEVDHVGCSVFGSLNSHLSTVVRNLSRPGDLHLVDIGSGYPMFDPIPLVFDKESPLYKTSFLYHKFLKDTDGTLRWVHRAYRDYYDGPPADVVDEWYTFMVINLEVRDIKFFFPNMENIHTVESGPKALAPFLVSLRAIDYRNGRLFAVKDTTILKEDASGKVNKKRISSPQELLEAYKVHFPQFPAETVQQAIQQVTLKFQNSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLM8</accession>
    <name>A0A913ZLM8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038052682.1">
        <property type="nucleotide sequence ID" value="XM_038196754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196754.1">
        <property type="protein sequence ID" value="XP_038052682.1"/>
        <property type="gene ID" value="LOC119725356"/>
    </dbReference>
    <dbReference type="GeneID" id="119725356"/>
    <dbReference type="CTD" id="68260"/>
    <dbReference type="OMA" id="EHSWVKH"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000131">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2/3/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="503" mass="56196" checksum="FCE733C9828B4B94" modified="2023-02-22" version="1">MAASMDEAEDDLSMMDTAIVVYTENAQKMRLFLEEDRYWDSCRRLQKLEGNVIAIPVETSISLAINRVSTNEDAKMLQYGGKILKSGHYRDLPCHLVSVSLPLSKKQLAVSPHQRLVDVLRGRFEELDIPFPGELREEIPAVWEKHEDLVLLPQLSFRSSVWQRCLNLWPLVARALGGQRLARKGRIKQDEFRSPRVELLLGNDGWVEHRDNGIRYTYDVTHCMFSVGNITEKMRVAHFDCRGETVVDLYAGIGYFTLPYLVYAKAAVVHACEWNPDAVMALKKNLVLNGVQDRCIVHQGDNKKVCPRGVADRVNLGLIPASEEGWPVACAALKPQSGGVLHIHGNVTSRTTMRTKETMPRRTQSHELVAQECGKSSSGERTASDVSLSPAGLRTANPSHPTGDSKNDLKPHEGAVDEGTQQEAEQSFGSTTSVDTDLQPKDYWRSWAQSTARKIQELLAEIQGGRWTTEVTHVEHVKSYAPHVDHIVADIRCLPLEPNPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLZ4</accession>
    <name>A0A913ZLZ4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038052813.1">
        <property type="nucleotide sequence ID" value="XM_038196885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196885.1">
        <property type="protein sequence ID" value="XP_038052813.1"/>
        <property type="gene ID" value="LOC119725477"/>
    </dbReference>
    <dbReference type="GeneID" id="119725477"/>
    <dbReference type="OMA" id="WMIMIAV"/>
    <dbReference type="OrthoDB" id="5962891at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="36976" checksum="DC41953194A371E0" modified="2023-02-22" version="1">MLEYPKISEFRKSRLFLLFFFGVYAHRLLASNMVDTLQALNTALLVVCSAAVVSNVLAVVIFAATKKLRVKYYAFAFNLVLGDIVAPASILILINANLPKLRPLYSTSLCAVKLSILAIAVNRFLALTITPPARYDAMVTRGRMLAACVLIWIISAAILVPTLLHSKLLARMLQSSTTLGILLITAVFYCAVFRKMSRYTPPLASTEGARADDAVARTRLRQTRHLMITFTIILVTCFACWIPYCIVNFMVYFSGKSMRMSVGPRNLSILSRLVATILMFNSLINPFIYWWRIREFRVSMYRLICRGRGKVDPENDVVTLHTMQEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNP2</accession>
    <name>A0A913ZNP2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052666.1">
        <property type="nucleotide sequence ID" value="XM_038196738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNP2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196738.1">
        <property type="protein sequence ID" value="XP_038052666.1"/>
        <property type="gene ID" value="LOC119725343"/>
    </dbReference>
    <dbReference type="GeneID" id="119725343"/>
    <dbReference type="OMA" id="GSGINEM"/>
    <dbReference type="OrthoDB" id="10061577at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077:SF9">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19097" checksum="EFEAA91B9633B6EF" modified="2023-02-22" version="1">MCLQMDPETSVSTLKQIICEKISVRPQQQRLYIRRNFRNFELHNLLTLQDCGIHQDENISLRLCTDGLLGGGRKDAPPDSKSILSLSVDIGTDWEKLAINLNFSEGVLNTIRSNRPNNSEMQCFEMLNKWWNKQENYPEAWQTLEKALIDSGRNDLARRLSGMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQ48</accession>
    <name>A0A913ZQ48_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038053903.1">
        <property type="nucleotide sequence ID" value="XM_038197975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQ48"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197975.1">
        <property type="protein sequence ID" value="XP_038053903.1"/>
        <property type="gene ID" value="LOC119726319"/>
    </dbReference>
    <dbReference type="GeneID" id="119726319"/>
    <dbReference type="OMA" id="IFRISCY"/>
    <dbReference type="OrthoDB" id="6078428at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="418" mass="46432" checksum="C4DFD4279A280B65" modified="2023-02-22" version="1">MENTSVPNSTALFENAESDSGLSDTAGNIFQLIVQSVIFLFGVPGNCLILRVYWTKTLKTSTHVFIMGLAWADLVVCVLAVHRIYDKVADMAGYEVPQFTFIIWALDTTAIATSIMMTAVIAADRYDCVCRPHRRFFTHKRGKISAFAAFVFSLVINIPAFIPTTPASRQSLGRLRLAFQVICFVVALVMIALCYGKVYMTIKKHTKVGVKSTTGDRSVSRLADEWSTRLQDSVITNVGPNIPTVSSVSTLISKPCSSAVADGSRMALSKGPSSREIDESTLDENGIRLASHSQATLTKRVLLLKETESRVANRNSDPSQRQSNAERAPPKTNAAVLQRKTTRMLFITSVVFLLTWLPYWMRLAAVFASYYDPVFRMILEQLSVTLYVNNAVNPLIYGLANRRFRKDCKTILSKIKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZS65</accession>
    <name>A0A913ZS65_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054239.1">
        <property type="nucleotide sequence ID" value="XM_038198311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZS65"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198311.1">
        <property type="protein sequence ID" value="XP_038054239.1"/>
        <property type="gene ID" value="LOC119726574"/>
    </dbReference>
    <dbReference type="GeneID" id="119726574"/>
    <dbReference type="OMA" id="MEKCITS"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037869471" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18004" checksum="51409C174E5A1DB2" modified="2023-02-22" version="1">MAFRKISCVMFFLVLGLVSADDCPPFWTRYGNNCYRFFGPPKTWQSAEEHCGEFFTRDGQGHLASARSSGENNFLLQMWSTSLVSNDGVVGASVWIGLNDLANEGRFTWSDGGHLNYNGGWRTGQPDDGGQAEDCGCFWRTTEQVGWNDEGCGLALPYSFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTC0</accession>
    <name>A0A913ZTC0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KLHDC10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054311.1">
        <property type="nucleotide sequence ID" value="XM_038198383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTC0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198383.1">
        <property type="protein sequence ID" value="XP_038054311.1"/>
        <property type="gene ID" value="LOC119726629"/>
    </dbReference>
    <dbReference type="GeneID" id="119726629"/>
    <dbReference type="OMA" id="TICAEGN"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="398" mass="45714" checksum="71331C88A7578321" modified="2023-02-22" version="1">MLSRADTDAEMDRTDVGKFVRIKPEGIEPYPRSGHCSTTDGNNMIVYGGYNPEYHKSGTGPGHEDVVIENQVFTEMWCFNLNTETWREVSTVGEKPTATTGMSMILDTSGHMLLLHGGTGHPWGRNNNGDLIAFVLSERRWKPLQCTGDCPAAKYGQAIVLRQGHLYCFGGCRWLPDVEDFLFNSELHCLDLKSQTWSLLYDDPRNESRVMYKHGLALYENKLYVVGSSYGDLYSLTHQEKLHVFDLHTKEWKIQDTLRCLRHGYPRQRKYHGWVQWKNEVYICGGHNNRIVLRDIWKLELPSLQWTRLPTNLPVTTYFITAAITPTKCLYTFGGITDLEDRPRTNAVFRLWLAIPPLLDLALKKVLTLLPDRNAETIARLRDLGVPFNVMDKLRHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZV81</accession>
    <name>A0A913ZV81_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038054981.1">
        <property type="nucleotide sequence ID" value="XM_038199053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZV81"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199053.1">
        <property type="protein sequence ID" value="XP_038054981.1"/>
        <property type="gene ID" value="LOC119727193"/>
    </dbReference>
    <dbReference type="GeneID" id="119727193"/>
    <dbReference type="OMA" id="PIGMIAY"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="456" mass="49264" checksum="868650A2C43BE303" modified="2023-02-22" version="1">MASSRNATTRQYDHDSWGWVMVATAFTCCLVLYGNLKALGVLLIPMTNDLASDLWLVGWVAVLYDIMHNCMGPVVGALSRLLGSRPMMVFGGLLTTLGFMLTSISSNVFAVAVFIVGLSGIGTAFSTFISLALTASYFKDKYPLANGLSTMGGPIGMIAYGPVTQLLLGTYGWRGTMLLVGGISFHLVACAMLVRLDPSSSSPDNEQYQEVSVNDGDENQSAGEVRDCTDDKTDNSKKCCCDPDHRQYRTGMCCRNIVKAIDMALLTDVRFVLLTCARCTANFTYSAWVVYMVSHGQFQGLSEIQASFLPTAFGVGNVIGKLVLPLLQQIGIKPSMTFWACFGAGIVSVSFLLDAFIRPFIGQLALTGFVGVGYGVFFQALDVMVRFLVSDHRFVSVLGWQGMFVGVAGTLGGLISGWIYEWTGGFSIVLCVFAGVTLLSIPFFVTEALYAKRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVJ5</accession>
    <name>A0A913ZVJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055565.1">
        <property type="nucleotide sequence ID" value="XM_038199637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055566.1">
        <property type="nucleotide sequence ID" value="XM_038199638.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038055567.1">
        <property type="nucleotide sequence ID" value="XM_038199639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199637.1">
        <property type="protein sequence ID" value="XP_038055565.1"/>
        <property type="gene ID" value="LOC119727652"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199638.1">
        <property type="protein sequence ID" value="XP_038055566.1"/>
        <property type="gene ID" value="LOC119727652"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199639.1">
        <property type="protein sequence ID" value="XP_038055567.1"/>
        <property type="gene ID" value="LOC119727652"/>
    </dbReference>
    <dbReference type="GeneID" id="119727652"/>
    <dbReference type="OMA" id="CLSVWKC"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72343" checksum="7CF92CB4B90181C6" modified="2023-02-22" version="1">MEALPVDDETDGKGTEPTDEGTDNDGNGGEDAGGRGNWSGKLDFLLSCVSYAVGLGNIWRFPILCFENGGGAFLLPYVIMMLVVGMPVFFLEMAMGQFSSLGCLNVWKCTPIAKGLGYGMLMIAACIATYYNVIIAYTLFYLFASFTKELPWKTCDNSWNTPNCRVSKACKDCDTYTGNDTYLNSTYFNGTFDDDTFGLYDVYDDDFDNSSERNVSTTRPSEEYFNLRMLDVSDGIHELGEIKWELTLCLLLAWILVFLSLAKGIQSSGKVVYVTSTFPYLVLISLFIRGITLDGAIDGVIFYMNPNPTKLLLPKVWQDAAVQVFFSLGCSFGTLHTLSSYNKFHHNTLKDAVIVSWLDCLTSIFGGFVVFSVLGFMAQDAGTTVDKVVDSGPGLAFIAYPEAIARMPLAPLWSVLFFVMIFMLGIGSEFTLFEAVLTGLVDDLEKNIKNFRKYKTLLTLGLCIICFLLGLPMVTQGGVYIVTLLNTFVANVNLLIVSTTEIIVVAHCYGINRFLVDMKAMLGFKLNIYWKISWWIVSPIALLCVTIASIVLNTPLKYGDGTPYPDWAQAIGWLIAMSTLVPALVYPMYYIYGLQGTILERIRLSVKPTPDWGPALDKDRVVAGYAPLSGTDPQEYERMVEQANDAKDKETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZW16</accession>
    <name>A0A913ZW16_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055848.1">
        <property type="nucleotide sequence ID" value="XM_038199920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZW16"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199920.1">
        <property type="protein sequence ID" value="XP_038055848.1"/>
        <property type="gene ID" value="LOC119727846"/>
    </dbReference>
    <dbReference type="GeneID" id="119727846"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="248" mass="28193" checksum="65CC2DC96C74B085" modified="2023-02-22" version="1">MSSYKERWVREKNRKRMQKRREKEKNRKKKVKTPSPASTSEQAAYMTVFECLQQTQQDKEHKHRKNTRKFFLWKFASKTSKRYRIRHQQEHGYQNQATDLQEIVSLKRRVRELESQLRDKEQIITQLKSDQVTAHSGHPFSIDITPKKIRLMKELTSMVEGTAAPPPPPPSPLPQTSPPKTSPPPQQTAPPSTRTSPPPPPQTVPPPPAPRTASATPVVAAQPPPVSTSPSFPALSNTVLPFVKSFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWC3</accession>
    <name>A0A913ZWC3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055953.1">
        <property type="nucleotide sequence ID" value="XM_038200025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200025.1">
        <property type="protein sequence ID" value="XP_038055953.1"/>
        <property type="gene ID" value="LOC119727945"/>
    </dbReference>
    <dbReference type="GeneID" id="119727945"/>
    <dbReference type="OMA" id="NDINEHY"/>
    <dbReference type="OrthoDB" id="5875591at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037823946" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="33"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="156"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="290" mass="30277" checksum="A080D848B685B990" modified="2023-02-22" version="1">MATREQRKPTGLLQLLPLVILLLWLSSNHCVAQEEPTDSNCCSACFQGPAGTPGVPGIPGNPGGNGIQGLLGPKGDPGLGLPGPTGETGVQGRKGDRGEPGMLGPPGKQGLAGRNGDIGERQKGDKGEPGIQGPLGPLGGKGQKGQPGDATLVTPTPPSAVAFTAYITSPVSGYSEDQVIIFDNIMTNLGGGYDSQTGLFTCLIPGAYFFTTSVQRMLSSRNPFVQLKHNSALIFTAYDNHHNHYHQSSNSAVLVLTRGDRVWLEVGDGNGIHSSTNRDSFFSGFLIQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXJ5</accession>
    <name>A0A913ZXJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038056272.1">
        <property type="nucleotide sequence ID" value="XM_038200344.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200344.1">
        <property type="protein sequence ID" value="XP_038056272.1"/>
        <property type="gene ID" value="LOC119728207"/>
    </dbReference>
    <dbReference type="GeneID" id="119728207"/>
    <dbReference type="CTD" id="5198"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000010">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000028">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000001">
        <property type="entry name" value="Putative phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="40"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="192"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="454"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="689"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="872"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1353" mass="146389" checksum="44A0BF7775F525F8" modified="2023-02-22" version="1">MAVLHFYSSPGIQAGAAKACLDRVKSLLKDAGHVELKTEICYNVEVPDKDSLNKEDLQVLHWILATPFESNSLASKSFLGDEKSSEDDVIIEIGPRLNFSTAWSTNAVSMCQSAGLDQITRIECSLRYFLRATTADDAPMTIPPDVVKEITGSLHDRMTECRYAKPLDSFAIEVSPEPIFDVNVMGEGRKALEKANKELGLAFDDWDLEFYTDLFRNKAKRNPTSVECFDLAQSNSEHSRHWFFKGRMVVDQEEHPLSLFKMVMNTQATSNQNNVIKFSDNSSAIQGYRVQTLLPETPGIGASSFRKQEAERHIIFTAETHNFPTGVAPFSGATTGTGGRIRDVQAAGRGAHVVAGTAGYCFGNLHIPDYELPWEDTSFVYPSNMAPALQVAIQASNGASDYGNKFGEPVLTGFARSFGMLVGNGERREWVKPIMFSGGIGSLESGHVTKEQAEPGMKVVKLGGPVYRIGVGGGAASSIQVQGDNTEELDFGAVQRGDAEMEQKMNRVIRACIEMGEKNPICSIHDQGAGGNGNVLKEISEPAGALIRAKEFQLGDPTINTMELWGAEYQESNAILVPEGASKTLRDICCREKCSVSFVGDITGDGRIRLELEDDLVENGGVNGESTNKKMRSCSYPVDLELEWVLGSMPRKVFNMERVKPKLKPLDLPADLTVRDAINRVLRLPSVASKRYLTNKVDRSVTGLVAQQQCVGPLHTPLADVAVTALTHFDTVGSATAIGEQPIKGLVDPACGARMSVAEALTNLVFARVSSLKDVKCSGNWMWPAKLPGEGAALVDACVAMCDTMKQLGIAIDGGKDSLSMAARVAKETVKAPGALVISAYVGCPDIRATITPDLKCPGGCGSILFVDLSCGHSRLGGSALAQCYKQLGDSVPDLESTAVLVNAFNVTQELLAEGLLTAGHDVSDGGLITCLLEMTFAGNCGMEVNIPNNNKASSLELLFAEELGLVFEVSAQNAEAVCQRYAGKSVLCSVIGQSCGQGPDSMVRVSVDGSDVLTDKMTVLRDAWEETSFRLEALQANPECVTEERLGLGQRVAPPYKLTFDPNKHKIDAELAKPGFVRPKVAVIREEGSNGDREMVASLFAAGFDVWDVNMHDLATGNVTLDRFRGVVFVGGFSYADVCGSAKGWAAAILFNPTVRAQFDAFRARSDTFSLGVCNGCQLMGLLGWVAPDHGQGMPDADSASSKQGVFLTHNKSERFESRFVSVGISQSPSILLQGMEGSVLGIWVAHGEGQMKFASDAILDQVTQNNLAPIRYVDDQGQPTTQYPLNPNGSPEGVAALCSPDGRHFALMPHPERCTFTWQWAWIPQEWQREVKVSPWMHMFKNACAWCHQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0L9</accession>
    <name>A0A914A0L9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057135.1">
        <property type="nucleotide sequence ID" value="XM_038201207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0L9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201207.1">
        <property type="protein sequence ID" value="XP_038057135.1"/>
        <property type="gene ID" value="LOC119728807"/>
    </dbReference>
    <dbReference type="GeneID" id="119728807"/>
    <dbReference type="OMA" id="HVLITEC"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="639" mass="71280" checksum="CE9B0D779C716485" modified="2023-02-22" version="1">MAEAAAKTVLDKISQGHLECPICCCLFKDPKMLDCLHSYCLKCLEEMMSKQRPEAGKITCPVCRRETQVPDGGLQSLSSSFFLSSLVDEVKQQEAALGEASAPTATCDCEEGKEATWRCLDCSDNLCQECWKAHGRFKSTKDHQIISLGDWHKSKMPPAEHSKSITRMCTIHTDHPLCFFCDTCDTLICSMCAALDHRSAEHNFLKIDDLIRSFRSEVGNILQKFEKSRQHFKSTEKSIEHAQNRLQKKLAQARSDIDAKAEAEITKIRNKAKLLTDKVNKIGQERDSEYEKALTHNREQMERADQTIAAVNDLMSQADGLELLELKPKVMHNLEFQKELKCEPVNHGPSFIGVRCHDVVNDAELGEVCVSEKWQLKEEFGKEGTGDEEFDYARAVACFTNGDIIVSDTHLKRLSLFSPTGRYKTSVAKGNRRHQLEAPWGVAVTHDDLLFVTDKKKVKVFDTELHCVCEFTPSGDDADGLSKSDLTAVAVDSQRVAVADRGKKVISVHNLDGSLIASISNNMVEHFLTISNFGCLVFTNYKGESLLCVNLKGKEMFRVKILVTGEAAKPTGVLCDDDETIYVAVHEKKKGTEVQRYDSNGALVATVAQGLFNPLEMAFTPTGDVVVADRHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0Z2</accession>
    <name>A0A914A0Z2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057548.1">
        <property type="nucleotide sequence ID" value="XM_038201620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0Z2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201620.1">
        <property type="protein sequence ID" value="XP_038057548.1"/>
        <property type="gene ID" value="LOC119729102"/>
    </dbReference>
    <dbReference type="GeneID" id="119729102"/>
    <dbReference type="OMA" id="FDARCER"/>
    <dbReference type="OrthoDB" id="10580944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="616" mass="65505" checksum="FDBBD742565A5721" modified="2023-02-22" version="1">MEGTEVQPHLIYIPVFVVVVFGVLVFAFGFRSSTQPPSSMFEDENEKRNRRGRRVKKLSGSETKPSTNGHAKLLTDNSPKEDKQVKGPKVEEGRVQKDTAPKISPKKDKPVKNKVSEGHAVKEQDAPQKLAVTSEEGRKVKEKEKDEGEAWITATSRKEKKHNKQVNGEPLAKSANKSTKASPRGPGDDQKASQKDKKDAVAKERGGGKKEMPQKPKGSPKKIVENQIKASSVPATQSAPVPESSPDQGKKRKKKGQAEQQEAANKTAEPAALTNGIAGDSDPANQKKDAGTDEDGFTPGKSRKGRKKQKTTQEDGSKQSPPTEDKKQKSPPSSPQDSSAKKSGKKSPDKTSPSKTKPAAKTEKAPAVPTPEGSPAKKADGKASSPAKTKKNVKKEEASPTKADAKPSKDKKSGQKVTNSAPSSSEASPAKSKSPADGSPTKSGKKGGGDKTSQQLKKDDKQLQETQAPSSTSPAPDTKSKSKKKQKKESAPSTPEAISKQPASPKSKVVPSPEPKAESVNSKSSGKKNKRKGGSESKGKPSEAVNGEASHSLPPANAKEVPSAKTPDKTGDKVSLDPPTPKPEPVAVAEVPAVQENDNWVEAKPKKVRKKVRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A154</accession>
    <name>A0A914A154_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057081.1">
        <property type="nucleotide sequence ID" value="XM_038201153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A154"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201153.1">
        <property type="protein sequence ID" value="XP_038057081.1"/>
        <property type="gene ID" value="LOC119728773"/>
    </dbReference>
    <dbReference type="GeneID" id="119728773"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="640" mass="71446" checksum="1FA2D7BF60B3150D" modified="2023-02-22" version="1">MAEAAAKTVLDKISHGHLECPICCCLFKDPKMLDCLHSFCLNCLEEMMSKQKPETEKITCPVCRREMQVPDGGLQSLSSSFFLSSLVDEVKQQEAVLGEASAPTVTCDCGEGKEASWRCLDCSDNLCQECRKAHGRFKSTKDHQIISVGDWHKSKMPPAEHSKPITRMCTIHHDHPLCFFCDTCDTLICSMCAALDHRSAEHNFLKIDDLIRSFRSEVGNILQKFEKSRQHFKSTEKSIKHARNRLQKKLAQARSDIDAKAEAEITKIRNKAKLLTDKVDKIGQKRDTEYEKALMHNRDQLERADQTITAVNDLMSQADDFELLELKPKVMHNLEFQKELKCEPVNHGPSFIGVRCHDIESDAELGEVCVSEKWQLKGEFGKEGTGDEEFQFATAVACFRNGDIVVTDTILKRLSLFSSTGRYKTAVAKGGLMHQLEAPWGVAVSYDDLLFVTDKQKVKVFDTELHFVREFTPSCDDVDGRSESNLQGIVVDNQRMAVANEGRKVISVHNLNGSLIASISNSMVDHDLAISNFGCLVFTNYEGQSLLCVNFEGKEMFRVKTLMNGKAATPAGVLCDDDETIYVAVHSGKKGGFQVQRYDSNGAFVAAVAQGLYNPIEMAFTPAGDVVVADLHSVKIFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7K2</accession>
    <name>A0A914A7K2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase kinase kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059770.1">
        <property type="nucleotide sequence ID" value="XM_038203842.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059771.1">
        <property type="nucleotide sequence ID" value="XM_038203843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7K2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203842.1">
        <property type="protein sequence ID" value="XP_038059770.1"/>
        <property type="gene ID" value="LOC119730812"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203843.1">
        <property type="protein sequence ID" value="XP_038059771.1"/>
        <property type="gene ID" value="LOC119730812"/>
    </dbReference>
    <dbReference type="GeneID" id="119730812"/>
    <dbReference type="OMA" id="GHSMELM"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000220">
        <property type="entry name" value="mitogen-activated protein kinase kinase kinase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="789"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="95361" checksum="8DDB358B659667D5" modified="2023-02-22" version="1">MSLPTNDVNGCTFVEISFDDLTFHECIGDGTFGSVYRAKWISQDKEVAVKKVLTLGKEAQVLSSLSHRNIIQFYGAATVAPNYCLVTEYAALGSLYSHLADPANDVDFKEILTWARHVALGINYLHNEAAVKVIHRDLKSKNCVICEGMIVKLVDFGASRFHGSTALMTMAGTFPWMAPEVILGEAVSEKCDTFSYGVVLWELLTREVPFKGVEGFQVAWAVVEKNERLAIPSTCPDKLAALILPCWETDPKKRPAFKDILKTLDRLIEDKPLSEETGTFLMQKEKWKVEIDEVMTRIRQMERQLKDKENKLDTRESRLRHLEDALAGQIVVPFSADVKHDANHWSEQEVYLWVLQLQAKVPGQKRSDLAQYANLMLEHNITGRRLLLLSMDDLLALGIKSLGHRKDLQLEIQKLTLDNYRLQHFPPLSSVKSIPTTPTKSVGSNKTLTGSQPTTFHLTLIFGNLCRPGPTPEEYKWKVYVETDCDDNSSRCIRDVTLSLGEPGAKESFRHPPYVMTNWRVSKRGSNIGVECTVTYWDSIKKPKSTCHVHKVTSNDKNQPSERKIKLTGTPPARSSSPLPSSYDSGGSGSLGTLQGVWSTRKLQNSMDPGLYESIDKKPGVWSGVVAGKVTPAASKTNPTPSPKINPLHEGFSFAPPVDPTTPPPQWPVRKNPSTGTPPTLPLGSRSPFAVDCTINHTGVKSQVDSDDDSSSAGYRTANSSLSTPSPEIRRLRTGHHLDRNLSHSSTGADPTPPKSSSPGMSNQEWLYPRSRSVSSGIPLVGVQREVYRHRLHSPSRNRRKSGNRINSGLSPQDLQRGRSTGESGTHTAADSRVTNRGHSGSERGHQRNSWAGQSYNEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8U7</accession>
    <name>A0A914A8U7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartyl/asparaginy/proline hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059834.1">
        <property type="nucleotide sequence ID" value="XM_038203906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8U7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203906.1">
        <property type="protein sequence ID" value="XP_038059834.1"/>
        <property type="gene ID" value="LOC119730853"/>
    </dbReference>
    <dbReference type="GeneID" id="119730853"/>
    <dbReference type="CTD" id="57168"/>
    <dbReference type="OMA" id="HIPSKDC"/>
    <dbReference type="OrthoDB" id="438431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="340" mass="39045" checksum="DBD1A464EB389030" modified="2023-02-22" version="1">MAHEYKMSVMLQIQELLYHTLLLTICFGLLIAVIIQCFLNWRRKGILYKNAEKRQENANYDDFSKCTSSSCVRCQNYERLTLDLMERFVKYKDVKSDEGEQDLTRLQISIENSLKMLKNGEDKSQLGDETSLPSLQKPNVFFLRGLSANPWHDGGFDTETSVLEAALPTIKQEYRELLTEQNISENFEGWLENNVPSGMWNVFYLFNQGRRMEDNCSKCPKTVAILEALSVFMKGCAFGNAMFSVLEAGTHITEHYGPCNLRIRCHLGLHVPANCSLTVAHQSRQWQEGRCLLFDDSFLHEARHAGKDDKGPRVVLMMDFWHPDVTAAEKRALCHLFPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9M9</accession>
    <name>A0A914A9M9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060557.1">
        <property type="nucleotide sequence ID" value="XM_038204629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9M9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204629.1">
        <property type="protein sequence ID" value="XP_038060557.1"/>
        <property type="gene ID" value="LOC119731461"/>
    </dbReference>
    <dbReference type="GeneID" id="119731461"/>
    <dbReference type="OMA" id="EVANVYF"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23977" checksum="7DCFB693835BBDDD" modified="2023-02-22" version="1">MSNYKLVYFDGRGRAETIRYIFKLAGVKFEDKRYEMSDWPAVKPTIPTFQLPMLEIDGKIILQSKSMIMYLARKHNLYGKDEFEGMCIDMIIDTADDVVPPWDLIFFSTTEEEKAKHTKNFQEVEVPLIYSRLERLRALEHMHAGDYFVSNKLTAADLHFASMVEVANVYFPNSLAKFPVLKAVFDRVVSNPVIAEWRKVRPVTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAT6</accession>
    <name>A0A914AAT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060977.1">
        <property type="nucleotide sequence ID" value="XM_038205049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205049.1">
        <property type="protein sequence ID" value="XP_038060977.1"/>
        <property type="gene ID" value="LOC119731782"/>
    </dbReference>
    <dbReference type="GeneID" id="119731782"/>
    <dbReference type="OMA" id="TEQFHRS"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000013">
        <property type="entry name" value="Vesicle-associated membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="111" mass="12523" checksum="5B75A65BDCEBB7F5" modified="2023-02-22" version="1">MDAPTANPDQPPRAAPPSNKRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQQGASQFETNAGKLKRKYWWKNCKMMIILAVIIAIILIIIIVVIVENTKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACP5</accession>
    <name>A0A914ACP5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061236.1">
        <property type="nucleotide sequence ID" value="XM_038205308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ACP5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205308.1">
        <property type="protein sequence ID" value="XP_038061236.1"/>
        <property type="gene ID" value="LOC119731968"/>
    </dbReference>
    <dbReference type="GeneID" id="119731968"/>
    <dbReference type="OMA" id="NEDEYNC"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037091320" description="SRCR domain-containing protein" evidence="14">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="263"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="366"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="51373" checksum="C539A5CE2B8D7AB7" modified="2023-02-22" version="1">MGKMDRLLILLLAVFITGTIAAPTVEVVNPPSPVVRLVNGSTIYEGRVEMFAYDAWGTVCGLSWDMNEARVICRQLGYGPAISASGAATYVPEPTNASPTEPPYYDCSSYEWQCYYNGECIQDYQRCNGYSDCYYNEDEYNCFGNAVAPTVDVNSPCSVVRLVNGDTIYEGRVEVFVNGSWGTVCDHGWAMREAQVVCRQLGYGPAIRALDDAAYGQGVGPINLVHAYCSGWESSILDCQSYFTDHCFHSEDAGVKCSGPATVRLVNGGASNEGRVEVYHQGEWGTVCDDGWGLDDANVICRMLGFPAAFNAWHGAHFGQGSGGIILDDVNCQGYESSIAECQHNGWFSHDCGHYQDAGVTCESGVRLVNGSSLYEGRVELIVNGVWRTPCSNTWSIGDASVTCKQLGFGSAISALRYAPYGPGIGLIVNLHCYGWENSILDCQSSTSTRCDSGEVGGVVCSANHEIDWLVVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE15</accession>
    <name>A0A914AE15_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061731.1">
        <property type="nucleotide sequence ID" value="XM_038205803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AE15"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205803.1">
        <property type="protein sequence ID" value="XP_038061731.1"/>
        <property type="gene ID" value="LOC119732345"/>
    </dbReference>
    <dbReference type="GeneID" id="119732345"/>
    <dbReference type="OMA" id="WRRANYE"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF53">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE 8F-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="36722" checksum="52B55FCF72F3CA88" modified="2023-02-22" version="1">MGMVGMMMMMMTKMMGMMGMMGMMGMMGMMGMMRMIHLNIRVAAILEGNAIVLLRCERVKANAGKVTQPALTLKDHIRHFVNKYAPNYPKKGYEFLRLLRRKRINQTWSRDDANVDRFRKDILAASGTMSARRALYLTKQNTPIGTQLPFYQLGDPVTMTESFHKLLPDKTIFEPHDRYRRCSVVGSSGVLSGSGCGAEIDKADFIFRFNLAPVKGYEDDVGTKTNFTTVNQFILSKGEDPLVGKESIAAFDALQRQFQGSLLWVPAFSQRGYYEFVQRIVNVSLASGIMKPVVQNPGHFIGMMRLWRALHRRSDWPSTGTVMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEI6</accession>
    <name>A0A914AEI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Mucin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062355.1">
        <property type="nucleotide sequence ID" value="XM_038206427.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206427.1">
        <property type="protein sequence ID" value="XP_038062355.1"/>
        <property type="gene ID" value="LOC119732821"/>
    </dbReference>
    <dbReference type="GeneID" id="119732821"/>
    <dbReference type="OMA" id="HRDNCVT"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036883488" description="Mucin-like protein" evidence="15">
        <location>
            <begin position="27"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2715"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="17">
        <location>
            <begin position="128"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="855"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="1107"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1612"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1653"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1693"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1734"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1856"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1899"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1945"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1986"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2027"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2074"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2118"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2276"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2317"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2356"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2650"/>
            <end position="2691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="49"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2825"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="86"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2829"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2085"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2128"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2306"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2345"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2386"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2681"/>
            <end position="2690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2854" mass="302995" checksum="74EF93D6931BD910" modified="2023-02-22" version="1">MYLSRDTVLVVCAAVVVLCAVQHVFAVPGPPSYTTKPSITWCLCDGTTESSTTPIPNTPGPSDYTTGVQESTNEVLKTTPEETESTAEVTASTAGSTESTTGVTASVAETTTSAAESTTSAAESTASAAEATTSAAEATTSAAESTASAAETTTSAAEGTTSAAEAITSAAESTASAAEATTSAAESTASAAEATTSAAESTASAAEATTSAAEATTSAAESTASAAEATTTVAEATTTAAEATTLAAESTASAAEATTSAAESTASAAEATTSAAEATTTVAEATTTVAEATTTAAEATTTAAEATTTAAEATTTAAEATASAAEATTSAAEATTTVAEATTTVAEATTTAAEATTTAAEATTTAAEATTTAAEATTTAAEATTTAAEATTTAAEATTTVAEATTTAAKSTASAAEATTTVADATTTAAEATTTAAEATTTAAKSTASAADATTTVAEATTTGAEATTTVAETTTSASEAATTAAEATTTAAEATTTAAEATTTVADATTTVAEATTTGAEATTTAAEATTTGAEATTTAAEATTTGAEATTTVAETTSSAAEATASAAEVPLLAAKVLKSLNGGRELATPIWCYCGSTSEPTVSTTEGPFTSTAGPGTSTTGPDTSTTGLGTSSKGPSATCTSAIGPSTITPSTTGPSTTGPDNCVTDGDNCNTHRNNCATHRDNCVTDGDNCDTNRDNCATHRDNCVTHRDNCVTDGDNCDTNRDNCATHRDNCVTHSDNCVTDGDNCDTNRDNSGTMPLRDPIPVYTFNFPKFHVHTLVTFYLPSKDRISPTFASRQFFPFGNGLYEFIYFTDNGVIILSNNRRVRRTIYKQAFPSTYSFSFNGNVKMIAPFWADVRADAFDSTNNVFWKLYDNPSTDSTMLRTLSNIVSAQYGSFLANWVLVITWSNVQSVSLSFETNTFQAILLTNGEHSYVIFNYDPCGMNWDPVYLYNHYVIQGFTCGRFGRKVYVDLLGRSVFRPGSVVGNSGMIGRWVYQLDTLQANFINPRLFCYNWYYRQRSSYIFFLYLYPVRVANTCPCSLQSARRDRRWVPIPYSYVLPTQFSLRFDQGVLVRYYCCEQSSLCRLYRRWRPIQSCRRYRPPRRGWNFGDPHMRTLDGLDYTFNGLGEYTMALIDDDDGQRQFELQGRTQRALNSETQQLSEATFFAGFAAEYVGDARIEIKLNSDGTDLETKVNGASVTPTADGLLIGNFTVLREEDPIKIIAVYQADIQFSVGVSNSFADITTQLSEDYMNKTKGLLGVWDGDKGNDALRRDNTQQTVTGPNGEQSEQDFFAFGQTWAISESDSLFYYVPPGESFSNMNDPSFTPKFLDNLTSEADPAKLQAAQDACGSNKVCLYDALATGSTDIGVASMQLSEQNTIDMMAATNFPPNVTLVETVEVVVGQPFILQIQAVDPDGDDISYELLEVIPGATVSSPGGQFTWTPADRSKVTLGFLVTDGKANATLEPIVKLCDCKNAGTCLYDEYVEGTNVITDGRFGVVLCNCTPGWSGDFCEMNYDACQDNPCFLGVACFDDDPPSLNFTCGSCPEGTEGDGKSCIDIDECVVYRDEPASNNGRGCDQNCVNTLASFNCSCNSGYSLFVDGKRCIDINECDSQTDDCADDATCNNTQGSYECSCNTGFNGDGTSCQDINECIGTNDCDNGAECANTIGSYRCQCRQGYEGSGFTCTDVNECSRNTDECNIQAMCDNTEGSYTCTCNEGLSGDGRNCTNVNECEGSTPVCHENATCTDIPGSFNCRCNAGFNGNGTDCQDIDECDLEIDNCLQNCRNTIGSFECVCHEAFTLLDGSCVANTNCSENSICVNGDCYVNGADIERCLCYRGYQNASDPMVCEDINECNATESYCGPSSTCNNTAGGFECLCSEGFRQGNDQRDCLDIDECTLPVDDPLYPVCIATAKCYNNHGTYDCRCKSGYEGNGTHCQNIDECQSGHLCVANSTCLDNAGSYTCHCNTGFHGDGRVLCMNIDECLEDPDMCHSLATCSDTEGSYQCNCDSGYQGNGTYCEDVDECMTESHDCASGRAHCVNNDGSYTCTCMNGYVSAPGMLPGRQCDDIDECSLNLDSCDPSVSQCNNTDDGSYICNCLLGFVKDDMNQCIDMNECEDPAACVSRANTECVNLHGSYDCPCRMGFYLQNSECLSGVSYNASAVFNIISGDLVGGNGFNLVTNYLKYRTELKDAIEAAFRSSDLSDNLGDVVISEISLLTDSTALLRLVINLNMSQPEQTIIQPFLSQLTGSSGGQLAPDHRLVGSTFIIGDPKCNSSPCTNGGTCADDNSVLPEGYTCTCLPGYSGKNCEIAPCGNNPCMNDGTCRVVSTTMTGYMCECALGYSGPQCQMIVPCELSNDCMNAATCVNEFVNARGYTCMCGDGFMGENCENECSLTCMNGGTRDPATCQCVCSPPWTGDTCTECSLTCINGGTTDPATCQCVCSPPWTGDTCTECPLTTASCLNGGTLDEEYCECVCPLTHSGDLCQDSNVCLTSDRCSDNTTGHYCVPSNTAFTCECRTYDAYFMEGAACENRRRFALTVVITLLTETYRSVYINPWSSAFRAKAALYKRLVERRLREDPVTNDVISADCVSIQNGSVVATMVLRYPAAPSTTDVQRVLLENRPLTDGDVAITTDPLALRVNEVTDCPPDYCQNGAMCLKSGYYVSMFTYTCSCGTSFTGERCETVIPVPTDVATATTTKSPGGISTAVIVIIIVACVVLFLTVVVIPLCLCLLIRRRNIESTHGRQKPDNPRINYGLSEYTDQSYYQDNGHDTSAIRDEEIRMDRLMNVMSRSSYLQQGLSSRPDFIRPYIVTGTEEFDQDDQHLDDPRDDDGTVGRVAYNPMIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFH5</accession>
    <name>A0A914AFH5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062473.1">
        <property type="nucleotide sequence ID" value="XM_038206545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206545.1">
        <property type="protein sequence ID" value="XP_038062473.1"/>
        <property type="gene ID" value="LOC119732963"/>
    </dbReference>
    <dbReference type="GeneID" id="119732963"/>
    <dbReference type="OMA" id="YGHIHHY"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF50">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="265" mass="29116" checksum="B75D08C340063C56" modified="2023-02-22" version="1">MLREFGKRGSGPGKFDGVVDITATQPGEIAVADYRNKRVVICSNEGQHKGTIPLQRPLAVAAIHNPEQRLLVLEDGSKYVKVFNMKDNTLDFKFPTVAPSEVEETQVNLKSTTVRTNGIILVGDIERMVWTEHRPTDGEILHTIPVQTPPQFLAVDDDTDRVVVSGFHTKKVDITDCKGSIHTTIKPTINGGPVWCDGVCCDSSGIYLAVDQGAAGTGHIHHYDQDGRFLDCVDQGLCFPLGITFTSNGQLAVAEHYFIKMYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG01</accession>
    <name>A0A914AG01_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062441.1">
        <property type="nucleotide sequence ID" value="XM_038206513.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206513.1">
        <property type="protein sequence ID" value="XP_038062441.1"/>
        <property type="gene ID" value="LOC119732930"/>
    </dbReference>
    <dbReference type="GeneID" id="119732930"/>
    <dbReference type="OrthoDB" id="6153184at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="3665"/>
            <end position="3684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7141"/>
            <end position="7162"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="6819"/>
            <end position="6910"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="7052"/>
            <end position="7097"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="7099"/>
            <end position="7133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3438"/>
            <end position="3463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6455"/>
            <end position="6476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6759"/>
            <end position="6778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7195"/>
            <end position="7252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="7273"/>
            <end position="7341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6455"/>
            <end position="6466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="7199"/>
            <end position="7214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7215"/>
            <end position="7227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7233"/>
            <end position="7245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7324"/>
            <end position="7335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="7087"/>
            <end position="7096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="7360" mass="813080" checksum="91106180B81EE6E0" modified="2023-02-22" version="1">[encoded data, 7360 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG09</accession>
    <name>A0A914AG09_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062905.1">
        <property type="nucleotide sequence ID" value="XM_038206977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206977.1">
        <property type="protein sequence ID" value="XP_038062905.1"/>
        <property type="gene ID" value="LOC119733400"/>
    </dbReference>
    <dbReference type="GeneID" id="119733400"/>
    <dbReference type="OMA" id="SQFQFAN"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134619" checksum="CD996C69CFB1E967" modified="2023-02-22" version="1">MDRSEKSSTSTTMSSLTQSDKYALAFQLVTQLTSLVDGVLFAKRMAVLQVIKEAWEKNTEVTVITEESSFDCGEQMNPDTAERMQSPQMAPVDSNLGSIEENPATFQALDVVVKQEVEHPGMPRIEQVVGYGLHPMGVAGYTDRALSSVDESGSSVTGSPEAENTRDLDQSPNTRPDFDQTSECPRGRLDTEDLFEDLGNNRAQVTVKKMSLDGTVQLGNGDQSPREDNGFDAYQDNSHVRKSFEDDENDEEEDSGDETDTGDVSTPQSVGKTRPFECKYCKRSFKFGEFSAGRPFHCPHCQHNASPREQGRLRSSPSSIDTPIGLSPKTSTPAVSPRKFPCPLCPKRFLRKGHLREHLWTHSKDKKISCAFCSKTCRTVKESRLHAKTHLNQNISNSNLNQLQSNRTTISPKPQSEAPHPMHLTRVSYSAEEETVAHASSNSPTSPGVNQWYRCDICEVDFPAETALAEHMKGHIAFPTRVDLQQHQRVHTGKGPTGRVRLEASRPTRASKSIRKKYERLRKHNDGFKCNLCYKVLFTVKGFQKHQENHTCKICFKTIKKLGAHMRVHSNMRPHQCPECLDLFKARKYLLKHWVSVHGKELLKCRACVRVFLDSDSLSHHEQEHHQLVEDKSCEEADPEVRSKETSHQCTKCRKLFSTNGNLRRHMIEVCSKSLVSEKMPVLTAAHCCPYCPKMFAYQNNLEKHMQIHTNKKPHVGRRFDCSTCQEVFATKAALIKHRQMQHKPTATGILDGKDSSAVDESLEQDESNHIDAGGVANKASPSSGSSKTHRSGIKPKYRCRYCNVNLSSKVRLLHHESLHIKNPSMIRKLGKYCCKYCNVNLSSKIRLLHHESLHIKNPSMIRKMGKKMPGRLTSPRQMHKKKVPKRMPASPIRKLGNTSSTQKGSKTSPKMASTGQISKVPKAKKNLSPRVACASTSQFQFANAPKSHTPNVTSLRSPSRPAAKQKSPNMSDCRSPSVHLPSTRPLHKMPKKSPIRKLGNTSSIQKGSITSPKMAGTGQISKVAKAKKNLSPRLAGASTSQFQFANAPKSHSQLVTSLGSPMRQTAQQKSPRMIDRRSPSKQGSITFELDNNPIIHQAYSKVFTSAEKRALHDQSHITHSSESKNAPSVSGTSIKQEKLYQCGFCNKVCKQRYLLTRHERQHTGEKPYSCTCGKAFPSVGSLRKHQKFHCTQKGQSDSMPANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG60</accession>
    <name>A0A914AG60_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062707.1">
        <property type="nucleotide sequence ID" value="XM_038206779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206779.1">
        <property type="protein sequence ID" value="XP_038062707.1"/>
        <property type="gene ID" value="LOC119733192"/>
    </dbReference>
    <dbReference type="GeneID" id="119733192"/>
    <dbReference type="OMA" id="EERRTHN"/>
    <dbReference type="OrthoDB" id="6152551at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="937" mass="107988" checksum="44B93A482C4903CB" modified="2023-02-22" version="1">MSKATYYRNKLKHNNPPKYEEYLQSQAKAAKQRRDKFKEDLAKRKPSVAALEQLKRKREQGRARKKKYMEKKKNNQNKNPPKVKINFRKPRDTDRTPAPTRAPTTGTRAATEAKQAYWRERKQAERERLKERPQKLRRIKEKDRNRKRQKRAEFLRKEQERQQQQNTERQGYQSLKTLRNHTTKARKALPKSPEKFASVVCGLVKNSSPRKKKALKNKGLTEATTFSPKIKEIAEKIKQNKGGREALKHFACASIKFATKVQISKHLKLNSGTIRRAIHTSGNRRHVGRGKMSVHLRQKITSFYLREDISRPLPLKRYATKHGPGHVLQMSLTAAHRMFQKEYPDSRVSYSKFTFLRPKNVRLLSKVHHEVCTCVYCMNIKYKLMVVNRVINTTKSTSGVVKIADEYEFVNKLLCPVSDSQRFQNEECVFGTCDKCGNLGDTIRKMYEPVIKEARGTWNWLHWERVEVIEGKPRRVLKTKQGSMGDVLEELINDAERPVQGVSFVKHIVTARWQHRQYSNLKEHLPENWAMMVMDFGQNRKVFYQDEIKAAYYGQMQITMHPVVMYYRQNGTLVRDSMIFLSDDIRHDYHAVEHYLNMASQHLASNMQQVDKEVLWSDGCQSQYKGKGTFADLSLSSDARERNYFGSEHGKGEGDGEIGVVNRAVDQAILGRKVVLNSAKDMWGWCCANLASDSMYSKRSFVYVAKDEISRERPETDVTTLKGSRGYHQIQVAAPYKLKVRRLSCFCFPCLLNNNEMCTNATYTGGKFEIKQLSLKAIRNVHARNRKGVSKAATEINDASVGSELESVNEPQSAPIRQSSRSASPVPPPSDPASIRPNAIECGHFVAVKLHGKRGTSDWYLAKVMDVTETAMCLSYLSKSGSYYVWPDNEDTSWQNRCDYLCHVDPQWTVIGSRIKMTLTSEDRNRCINTFNVSNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGT8</accession>
    <name>A0A914AGT8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062913.1">
        <property type="nucleotide sequence ID" value="XM_038206985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206985.1">
        <property type="protein sequence ID" value="XP_038062913.1"/>
        <property type="gene ID" value="LOC119733403"/>
    </dbReference>
    <dbReference type="GeneID" id="119733403"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036757851" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="7">
        <location>
            <begin position="27"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="9">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="587"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="107496" checksum="DCFBB6A96E3AAC73" modified="2023-02-22" version="1">MARQCLAMNLLLGTWLLAGCLHVGSSLVCPESRTRCSVGCLDKENVIPGTPRELCRCDPQCALYDDCCEDYWTNCVNESSSESRNRPILHSEYSEYLGCVSPIDIDPMNKRFVVVDRCPPDWAQGAIKSRCESTILSRQEKLLTLFVNGPGDIVFKNVYCTICHGIEEYDIRSWTVELWNCEPAEGETQPVLNGGKPDYTTCSNFHMEPPSMLYDPHRCYSSFVNRCTLSSTTTAEQMQLCENHTSLLFNQDVDVVYKNVHCWNCSRSTDVSNIQDLRCTQVLRDNRFNAAVSFTLIFDFTGRTVHSVERKGLFNGITSSPQLLRNCSQWQIYDPFQDVCQDLTCPNGQPPQSSSGACLDARQRKALGGSSNLSEDCIENLIAMNSSEMSTSTDLWTSADIADEGSDSPRHILNIYTSFASADRIQKSLDPILSNVTDTNSFASLSCNASLMILVASGESETNKKGICEGFSFGNISFSDLLVLDGVFSVNIGGFVYDQHEFMHETEYFFDINEASVIRRQSVTLCNPFVGSRRCSLLTLYPDDFFQSTDGGALIHAETGVPFLVGEYWLLPDGTVRVCQIVWYHVLGYVSYVGTCCSVLGLILALVTYGVFPSLRNTPGKIVMNLMGALLMAQLFLMFTDPKSWFCVLRALMLHFCWLSVFFWMNVLSCDLAYNLKCNVRPARPSRRGGSEGWKVLKLSAFAWGLPAVIVVSCFLASQFRPEWFGYGGSSCWIVGWITSAAFGLSISVAIIVNLAMFVYMVCIVIANHRRLVVARLAQKTKTTILLCFKILRSCFSSLRIQKQSCSRMMAKSALLISAVVLSLVCLASSKSCSYTCQWPDVDRALCDSRFFNIFRGIVRHVNKNSQEDYVDYAVEVMGVYRTEHSGLVSEGSTVNIRTTLHEYICPVVKMPVHFNAWFATGPLGQPQNDYRIATDSCTSFIATRLSPEVGNNLQRGKFNKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHI2</accession>
    <name>A0A914AHI2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062991.1">
        <property type="nucleotide sequence ID" value="XM_038207063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHI2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207063.1">
        <property type="protein sequence ID" value="XP_038062991.1"/>
        <property type="gene ID" value="LOC119733666"/>
    </dbReference>
    <dbReference type="GeneID" id="119733666"/>
    <dbReference type="OrthoDB" id="6193825at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="23636" checksum="264A6ABD560BAE03" modified="2023-02-22" version="1">MCRLGMYRPPWPAWRNCEGTALERRKTLPFFCFCWIHNVGYVSHVSPVRAGPSYNLRSIDVEDATNKRKIQVNLWGEDNKQDIPQPGTLVTVQNLVTATYRDMVVLNATQETDIQETEMACSSSKVTIVAITEESGNIIFMDEKNTEYQTTVELFSECTHYVDIRDALHLLPLDVQVTVTNVRGKNNVTSIATYDSSDVDSQLPNNPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AIN2</accession>
    <name>A0A914AIN2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat and IQ domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063508.1">
        <property type="nucleotide sequence ID" value="XM_038207580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AIN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207580.1">
        <property type="protein sequence ID" value="XP_038063508.1"/>
        <property type="gene ID" value="LOC119734216"/>
    </dbReference>
    <dbReference type="GeneID" id="119734216"/>
    <dbReference type="CTD" id="127255"/>
    <dbReference type="OMA" id="HVVNSIW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052859">
        <property type="entry name" value="LRR-IQ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46723">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46723:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96618" checksum="9287FC189973A076" modified="2023-02-22" version="1">MFTIHHQPQLALWLREREKPQRLKAIMEKERKSEFLRNAEEKGYLQSPTKDYLLERGRGKASKKEKSAKRAPSVSDIHLVKLCSVHLMNLGQIQLLTRLKICILPGNYITGFVALANCAELVKLDLHSNQISTLPGPEFWRCLPNLKILHLHNNCIGKLDSLQHMGQAGGIQVLTMYDTPISLKKTYRHHVVNSIWSIKALDFHVISDEEIIEDASFGGHFASMNPSFHYNPVPHSKKDSTFEDEMSLVQQVLEEVSSIQAHHSPVLIIQKVIKGFLVRRRQKLLLDTKIWASVCIQRFWRHFKGLEWKPPAKPATPTHTPAKPQAQPAAAPTLTKADSPLPPVAQSITDASTVTRIDYDTYLANRRPGSKTPSIVSSATADRKAANLEEIRMTGYSEDKDTGFSMPAMSSATPGISEPMSSMRKRTNLHIDLTKLQTDTMFQSDEARQAIVFETSIEEGISSFLGLSKPREQGLEPVKSSKKLQKDRRPKEKKKEFKTVKQMLGPLPNSQLEREREDDIDSDEEEPPVKFRLSGLKSVMHDVDLLQEMLIARREAGEDIRNSHKDVIDRALHESRQKPIKSKSVNADQRLFARVQGTMGMSCLRAVQQAYRDRAKAEKLVSTVDKVVSLREMKESSKQRARNFLEEKRLQALKKKDMDANSIAESLERRANLEKVEKAQRKERRSKSHEMSKSFSQDKSFAVDFTGQHTSISNALLRHDRQAKDDMALQGNRDTVEGERDHNKRQLELVQKYLEHRQMMRQAQVAVERAALDTRMLQEANERLMEARTRVTQQKQKSKSVQAFYPLPRTATDPVLPPVNQEGKPDRFHTLIAMYEGRVGNHPTVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM74</accession>
    <name>A0A914AM74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065130.1">
        <property type="nucleotide sequence ID" value="XM_038209202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AM74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209202.1">
        <property type="protein sequence ID" value="XP_038065130.1"/>
        <property type="gene ID" value="LOC119735495"/>
    </dbReference>
    <dbReference type="GeneID" id="119735495"/>
    <dbReference type="CTD" id="25790"/>
    <dbReference type="OMA" id="WGHKPET"/>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="10">
        <location>
            <begin position="183"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="549" mass="65192" checksum="DEB0CB8444695751" modified="2023-02-22" version="1">MPRSVQSTQSAGSSGSRHANTRKYFTVSKTSTVDESLFGEHNAVARSRRNESRSAEPVLETQPTNGKKRTSGKREVVQVITKDLIRNLIVPRDDPSGQSVVLPRGEYHRIINAARVLTQEERNAIEERRQREKEAAQEAVNEGKLQMQARDRARQKNEKLNDLEEEAKQKAEYLLQKAKEQQEEQEDEIKHLNELILNAKCHAIRDAQILEKGQIKEERTDEEKRLDLMMEVERKRSLELQEEIERQKKEERYEGASQVLTQIAQREEERLLDQERRDQEAQHMLKYLEKLQMEDLKELERKHQMTLEAQKEISRANQEAEEQRVRRQEQEKLADLKVTEFTKKKAAREAEFEAEQERIRVEKEKEIARLRAMQERARDYMAEKDALRAKRNQEQREREWRQKEKEEAVKKAETEQMLKIAREVQVQNKEHFLAVQAKRERHEFERVLNAQNEAMEKEQVEEQDQHDKRLRHAEDVRKQIRQKEQLKVSERHSFFEEGVRLNEEARARRSKLDAIKQKKLDELRNAGVPEKYCKEVERRIEGPAVALFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AN25</accession>
    <name>A0A914AN25_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="16">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="16"/>
    <dbReference type="RefSeq" id="XP_038065008.1">
        <property type="nucleotide sequence ID" value="XM_038209080.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209080.1">
        <property type="protein sequence ID" value="XP_038065008.1"/>
        <property type="gene ID" value="LOC119735384"/>
    </dbReference>
    <dbReference type="GeneID" id="119735384"/>
    <dbReference type="CTD" id="5426"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000023">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="18">
        <location>
            <begin position="1532"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1176"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1289"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1945"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2012"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1289"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1952"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2029"/>
            <end position="2042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2284" mass="261274" checksum="7F5DFFE2ECCDA324" modified="2023-02-22" version="1">MVLQNSGKYRADKESSGARSDDSSEARLQRAIINDELDARFGFDRYKDPAERVGWLINMHPADILDENKKLISAVDYYFIQDDGSKFKVSLPFKPYFYVASKKDTEREVSSFLSRRFTGTLASIETVAKEDLDLPNHLVGLKRKYLKLSFDSTQELMKVRRSLMPAIKKNQEREKSSDSYASMLSSHLMGDEEVSAGHQKKLSDQMDNLIDIREYDVPYHVRVAIDKKIHVGHWYSVQGRGSMAPIITQRDDLLDRPDPVVLAYDIETTKLPLKFPDSEIDSIMMISYMIDGQGYLITNREIVSEDVEDFEYTPKPEYEGPFTIFNEPDEPCLLQRFMDHILEVKPNIMVTYNGDNFDWPFVEARCKAHNIDMFREIGFQKDAQGEYKSRHCIHMDAYRWVKRDSYLPVGSQNLKAATKAKLRYDPVEMDPEEMCRMASEQPGVLANYSVSDAVSTYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEAVYNKLTSDGHVLDMETYVGGHVEALESGVFRSDLPCRFRMVPEAFQTLMENVERTMRHAIEEEEKVPLETVTNFDEVCTDIKEKLAALRDTPARLENPIIYHLDVGAMYPNIILTNRLQPSAMVDEVTCAACDFNKPGARCQRKMPWMWRGDFLPASRGEYHRIKQQLEMEKIPPVNPGEPTRVFHEIPREEQAAMEKKRLSDYCRKAYKKTKVTRQEERTTTICQRENSFYVDTVRAFRDRRYEFKGLLKVWKRKVASATEKGDASEIKSAKNKEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCYTGASIITRAREIVEQIGRPLELDTDGIWCVLPASFPENYTVKTTNPKKPKVTISYPGAMLNIMVKDFYTNDQYQELVDPSNLTYAERNENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNFDGSLAELKGFEVKRNGELQLIKIFQASVFEAFLKGTTLEECYAAVAKIADYWLDVLYSKAANLPDSELFFLISENRSMSRKLEEYGTQKSTSIRTAKRLAEFLGDQMVKDKGLACKFIISKKPEGAPVTERAIPLAIFQSEPSVLRHYLKKWLKDPGRTNYDIRDILDWQYYIERLSSCIQKIITIPAALQQVANPVPRVRHPDWLHKKLLEKNDVFKQKKISEMFAPRQRNKHQENAEDDSQQGPASPGGVPDLEDIGSSQGRRPNGLNKPPIVTKRKRARVESAEGEGGARSRAAMEEEELAKSWQEVLGPAPPMGESKEERRAWLAYHKKKWAHQARQRAERSKRRRIDDSESARGGAIRVGPSNSLGQFLRRTARSLLDMPWQIIQIAETGHPGLYKLWSLIGSDLHCIKLLVPRVFYVNQRHPKETNEGPMWKKVNRALPRSNPSLNLYEYVVPEDIFQEHSNELNADLSAPEIEGVYETQVPLEFRALVKLGCICMVNKDNARFLAGKELETFDIGQLQFKTLAQFSYLQPGSLRRIYLYHNVVGSKAMFGLFFSNSPKATIFAVDTVRTNQMPNLTSMYQTERQAKIARGTEEEFLPPEMHNFEVQVEKDMTKVYRAINRLLSSYKDERKGPTFIAVQSPMDNMELARHIPMLDDFPMVRLHVNDSENLYSVLDWQRQGSRRLLQHYLNVDYLLLSYLEQSRYFHVPVGNLPEDTGIFGADLFYARHLQKHSHVMWASPTERPDLGGREADDSRLVTEFEESSSIEVNQSGCYHTICVELDMASLAVNTLLQSHHINEMEGSAGSIAFDATPQISLEDMVTGNAGAATLLSSYDETALCSVAFRIMKSMVHGWLRDVTTYSNVFADHQIVHFYRWLRSPSALLYDPALRRTLHNLMKKMFMLLIAEFKRLGATIVHANFNRVLVCTKKRRVIDGVAYVDYITNSIKSRDLFHGIDLTYKQCWELLMWLDPTNHGGVKGQLPKSLLNQEAGEESHDLEEEEESESLTPNGEDQENEIEMNWNVMNYLPTAAACQNNFNMIVAGYILAIYRNAQDEHRRSTPGNTPIRRRGQTQESQLAADETTTPHTVTYAQGLIDGELSQRLFAITQKIQKKVSGNKSSGRDASSEFPQLPGSHLPLNNPALEFVKAVCKILSLDSDVTNQVNRLQRNLFRLIGTGEFSDSAVWRDPCLSYVLPEVICRVCNHCRDLDLCRDPLLVQDGNSVALWQCIQCSTEYDVATIEQSLIEAVQRSSMAYTLQDVVCAKCQQIKMPNMSSYCDCAGNFATTVTSSSFLNKMKTFSNIARHYRMTLLQHTVDWVLQMNQTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APK5</accession>
    <name>A0A914APK5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065682.1">
        <property type="nucleotide sequence ID" value="XM_038209754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APK5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209754.1">
        <property type="protein sequence ID" value="XP_038065682.1"/>
        <property type="gene ID" value="LOC119735814"/>
    </dbReference>
    <dbReference type="GeneID" id="119735814"/>
    <dbReference type="OMA" id="CTSERYH"/>
    <dbReference type="OrthoDB" id="10052386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="49878" checksum="D0A59B709071E32B" modified="2023-02-22" version="1">MEMIACDDDQCTVVWWHYSCAGVCADTIPDTWVCSRCLPGTTEEIDSSPGPDPTVSRPPRSRKTRQKPKKTSETTDAVTTDAQPSAKKDKKARKPPKPAVKRPEAKFCEADALQKADHYFMSGLQQLQQHPICLGVYPTAVCMLSLVASLMAKTNTEALQDFCAATVSGLWFVITAGDSKYLKPEGYEILWRAFHKYRPEVNDKWIELLQAMGLYREGQHVHLVCQFLLQAVLHAIIEDRNKQDKPIDNPAETKSESLSPQEEQVLRYVSGYIPFSLFKNLNKQKNDTAMTYCKFLKSWKVDCSDETARTFLQYTNDWIDKQNRGGLFRVSDGVYLLFRAMEQETCKYLTKNNLKTFQGCDIQSTLLNNIKGSHRVQTYWCSLTQGKITGDTSTNLLNMTVKKWIKIRAKAFINVYLNLKKATHGNVGKKAEKALRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APR5</accession>
    <name>A0A914APR5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_038066025.1">
        <property type="nucleotide sequence ID" value="XM_038210097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APR5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210097.1">
        <property type="protein sequence ID" value="XP_038066025.1"/>
        <property type="gene ID" value="LOC119736090"/>
    </dbReference>
    <dbReference type="GeneID" id="119736090"/>
    <dbReference type="OMA" id="RISCVYK"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="351" mass="39014" checksum="A40629F487C99261" modified="2023-02-22" version="1">MYKNRINMAGNPERKKLRPGLKLTPIRVDTTQTDNSRPPGNLDNQATLSISGKGNFVVRAEDLTDIAELGKGAYGVVSKVVHTPSSTTMAVKRIRAQVNKLEDKRILMDMDVSMRSSDCPWTVEFYGALFQEGDVLICMEVMDTCLGKFQTKIKSMDVLIPEDILSRIAFSIVSALHYLQTELKVMHRDVKPSNVLVNRNGRIKMCDFGISGRLVDSVAKTIEAGSKPYMAPERIDPDITGNAKGYDVKSDVWSLGITMYELATNEFPYEKWGTPFAQLKQVVKEPSPKLPGGKFSAELEDFVDQCLKKNCSERPTYTRLMRHTYISTHSGVNDGDVATFVTGVLDTAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ77</accession>
    <name>A0A914AQ77_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038065793.1">
        <property type="nucleotide sequence ID" value="XM_038209865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065794.1">
        <property type="nucleotide sequence ID" value="XM_038209866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQ77"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209865.1">
        <property type="protein sequence ID" value="XP_038065793.1"/>
        <property type="gene ID" value="LOC119735915"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209866.1">
        <property type="protein sequence ID" value="XP_038065794.1"/>
        <property type="gene ID" value="LOC119735915"/>
    </dbReference>
    <dbReference type="GeneID" id="119735915"/>
    <dbReference type="OMA" id="HEINIRF"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="471" mass="52009" checksum="5A679D151FDB44EC" modified="2023-02-22" version="1">MAIGRGLYKYVATEHVLIVYMLAYSPIIPTQTQYIEKRIIEQLGVINFTQSKCDANKSSPEYRLREKVQQESSVWSLYLTATLALAVIFSANIWGALSDKYGRHVALVMPCVGLAANSAVNLLVVYFHLPLYVLIFGSLAQGIGGDITTFIVGCAGYNSDVTMPESRERTIRFILIDVFYCFAGSICQFSLGFIIRTFGFEAPYLSVIGFVVITAGFIICLLPDRRVADTVTFVNSREEEVPSNPLNIVKNVRRVFTQDKLRGWLLAGFNYIIFSNILVSVAWVAISVLYTTGEPFCMDPLYEGYYQGTMNGIYGIGVLFGGTVVCKYLSKFWSMHLASLTIVASLVITAVAQNYLTLYLGLAAGFFTFLTTPLCRTSMANLVGPNQQGVVFAFSGCLMSLAGFLSPIIFNAIYSSTLHFMTGFVYLTMALLVLISWGVIVLLHIFEPKRRNCYVAIDGQDVAGVNSDKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQU9</accession>
    <name>A0A914AQU9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038066028.1">
        <property type="nucleotide sequence ID" value="XM_038210100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210100.1">
        <property type="protein sequence ID" value="XP_038066028.1"/>
        <property type="gene ID" value="LOC119736094"/>
    </dbReference>
    <dbReference type="GeneID" id="119736094"/>
    <dbReference type="CTD" id="3145"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000004">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="362" mass="39770" checksum="F868C6249BD8A6C6" modified="2023-02-22" version="1">MADEIEGEVPNVIRVGSRKSELALIQTNTVIERLQELSPDQKFEVVTMETIGDTIQDKPLSSIGISSLFTKELERALADDKIDMIVHSLKDLPSVLPDGMVIATVCKRDDPHDALVLSKKHAGRTLETLPPGSVVGTSSVRRVAQLKRKFPHLEFKDVRGNLNTRLRKLDEGDNYTCLILAAAGLHRMAWEHRISQVLHPDVCMYSPCQGAMATECRSDNPRLMRFLSTLHDPVTLLQCVCERALLRTLQGGCSAPVAADSQVADGKIRLRAAAFSLDGSECVEETQSVALPPNSLEKVEPSDRTDPFRLYSFTVAPNLSHDALQAAEQLGSTVATAMLKNGADKILEAAKQEIEARRNKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASC8</accession>
    <name>A0A914ASC8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066359.1">
        <property type="nucleotide sequence ID" value="XM_038210431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210431.1">
        <property type="protein sequence ID" value="XP_038066359.1"/>
        <property type="gene ID" value="LOC119736412"/>
    </dbReference>
    <dbReference type="GeneID" id="119736412"/>
    <dbReference type="OMA" id="RTVHYES"/>
    <dbReference type="OrthoDB" id="10056126at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="569"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1133" mass="128240" checksum="9EF3F08A3E3DDB1A" modified="2023-02-22" version="1">MLDRLGGRALKLAKSFMYTRQPYTEALAALTDKYGQPRQLVQCEIAAIMATPAIKYGDTEAFEEFSLDVLSLVGMLQSLEGPDGIELRCGSHVDRLLSKVAPSHRTSFMEHCLKEGILKSNCSQTYTLPQFASWLRRKSQSHSFASRAVSGHTLSNPRPQRYQEQRISRKDTPTAVLMTVPKPKYKPQPYCPFCDNKEHYLGGCPQLKKLNTDQIVSWIQDKGRCWKCGRAHKPDECTLKKPCHTCKQANPSAWCDVKGCASSPSWPAGTIETYAILDDGSERSMLIQTAAEKLQLKGQPETVLLRTVRDDIVECQGSAMSLQVSPKGKPHIKYTINGAFSASNLCLSVYTYPVKALQQRYNHLRHLPLPVINQASPMLLLGADQTDLIIPQCPIRSGPRGAAVAIYTRLGWTLQGPTGNHDLQLEQRVFKTSTFPVTNDLLQHVQMLWQADVLPYANDKEVTRSKQDQYALKMLESKTTRVSLDGVQRYATPLLRTKDGDRFQVTKDAVLPTLRRAEKRLQKHPQLAKKHNELITKLVDSGHVRVLPDDEAAMSDESWFIPHHTVHHNGKYRLVFNCSFQYNNQVLNEHLLPGPQLGASLIGVLLRFRQHAVAISGDIKAMFHQVRLLPEDRPLFRFLWRNLKVEAEPQIHEWQVLPFGSTCSPCCATFAFRKHASDHKEQYPEVAESVDKSFYVDNCLDSLPSSREAKHLVHQMRNLLADAGFEIRQWASNDPTVVEDLPPDARSNGCELWLTYGDTDSLEATLGLQWDCSTDNLQYRHRTVHYESLNMRNMYKILASQYDPIGYLTPFTTRARVIVQDLWKTKCNWDDVLEPGAIRDQWQAWEMELPALTDIQLDRCYTPLAVDVKPSSYQLHIFCDASERAYGAVAYLRAEDKHHHIHVSFVMARSRVAPKRQLSMPRLELSAALAGAQLCQLLKRELSLPVKYVVLWSDSTTVLTWLKSESCRYKVFVGTRVAEIQTLTDVKQWRYVNTKNNPADDLTRGKTLTELAQESRWRDGPPFLLSPPDQWPVHPATPPEDVSEYKKSTFCGAVAVDPVDPPDLSKCDTWEDLIMATKEHRDWAADTGDPPELGAEDRANIELLLYRRAQQGRFPDDLAALKAGRDLPASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AV26</accession>
    <name>A0A914AV26_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038067945.1">
        <property type="nucleotide sequence ID" value="XM_038212017.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068320.1">
        <property type="nucleotide sequence ID" value="XM_038212392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AV26"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212017.1">
        <property type="protein sequence ID" value="XP_038067945.1"/>
        <property type="gene ID" value="LOC119737563"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212392.1">
        <property type="protein sequence ID" value="XP_038068320.1"/>
        <property type="gene ID" value="LOC119737786"/>
    </dbReference>
    <dbReference type="GeneID" id="119737563"/>
    <dbReference type="GeneID" id="119737786"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="508" mass="59913" checksum="243137488D6CCB5C" modified="2023-02-22" version="1">MDEEDEYILGEEDVEEDEMESSDFEGHFEMDDDEGSSQRDQIEEDDFHYEVLTPDDNVQLMVDTIREVNVVVQIPATITRILLNHFRWDKEKLMERFYSEDQDKLFSEAHVVSPYKKTPVRHSSRVATRSSGPVLEPCDICCRNIISTMMTGLECGHRFCMDCWTEYLTTKIMEEGMGQTISCAAHSCDILVDDCTVMKLVKDAKVKLKYQHLITNSFVECNRLMRWCPAPDCPNAFRASHLEVRPVTCKCGHICCFVCGENWHDPVKCKWLRKWIKKCDDDSETSNWISANTKECPKCHVTIEKDGGCNHMVCRNQNCKADFCWVCLGPWEPHGSSWYNCNRFDEEDAKKARDAQARSRQALERYLFYCNRYMNHMQSLRFENKLYSQIMKKMEDMQQHNMSWIEVQFLKKAVDVLCQCRSTLMYTYVFAFYLKKNNQSLIFEENQKDLENATEMLSEYLERDISSDALADIKQKVQDKTRYCESRRKVLLEHVHEGYEKDLWEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVA9</accession>
    <name>A0A914AVA9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067424.1">
        <property type="nucleotide sequence ID" value="XM_038211496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211496.1">
        <property type="protein sequence ID" value="XP_038067424.1"/>
        <property type="gene ID" value="LOC119737281"/>
    </dbReference>
    <dbReference type="GeneID" id="119737281"/>
    <dbReference type="CTD" id="5257"/>
    <dbReference type="OMA" id="CWIKQAH"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF8">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 7" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="8">
        <location>
            <begin position="15"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="9">
        <location>
            <begin position="874"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="6">
        <location>
            <position position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608734-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121678" checksum="21FEA9E39B4C54F7" modified="2023-02-22" version="1">MAAEDEDYVRQVKLLDSYYFRVKSQILHHQSPTIGLFPATTGDAKRSHVAHVRDSIYCAVATWTLALAYRKIDNDHGRTYELEQSAVKCMRGILYCYLRQTEKLEKFKYTKGEDNALHCRYDMVRGNTLPDSYHHLQIDLVSLYLLYLVQMISSGLQIIWTLDEVSFIQNLVFYVERAYRIPDYGMWERGSKYNTGKCELNASSIGLAIAALEASNGFNLFGREGTSWSILYVDPDAHGRNRTILQTLLPRESMSKNTDASLIPVISFPAFAVKNVEVKNRTFDKVIRKLKGKYGFRRFLRDGYGTELEDKNRKYYKPAEIKMFDNIEAEWPMFFVYMMIDGTAKGDTKQVEEYHNLLKPLLKESANGLVLPKYYYVETRHIEAERKNPHSQPRVASHEGEDPDQIFLWGQSVYLIACMLKDGLVDMDEIDPVGRYHGSSVRLTVRHNTRYSAFESTCKDMTVQMAFIAESARLQATLQTYGIQTQTPTQVEPIQIWPPNELIKAYQFLGHNDKLGLTGRPPRPVGSLGTSKIYRILGRTILCYPLQFDLTDFYMYQDRSLLVDDIKSLVAFVRRSWTMSGRPTICMLIKEDHLSGAKGSEMLDMLAMFKRGRCGGNRVKVDRLQTLIASSFVEHLDFQLPEGVASMVLFKRLEELNVTHLPLQTKSRHLSSPHSEDHEEEAFDVKKFERLPSWELVECLRHSINMEVQSGILGMLFHREGSNYLTDKGTVAEALNKLYNRAGVKEDWSTVRYCASILRKVIDSLSPSITSMLVSGKIVTIGVFGHEEELVLRPLSPNEISDIIFARCQKYNIREAVMQQEIIITVGKLVTTRPELFSSMLKIRTGWLLHAMRTELKIAFNETKPVHSLSPHSLKDLLVQVLETNITTASHYRTWLQQRQFSGSLNRTPPNFYDKVWDIMARMPSGIIIADYFLPQQPTLSDMTRTDLNFALRIEEMFSRIAHPEYRQLMVELLTVISTILERNPELEFQSTVNTDALIKETFNLFKEHHASQGKTCDMQDFYNTPPIATHGTMSFLAKVIVHHLLDESMDTSMDNCLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWW6</accession>
    <name>A0A914AWW6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068013.1">
        <property type="nucleotide sequence ID" value="XM_038212085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068014.1">
        <property type="nucleotide sequence ID" value="XM_038212086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212085.1">
        <property type="protein sequence ID" value="XP_038068013.1"/>
        <property type="gene ID" value="LOC119737622"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212086.1">
        <property type="protein sequence ID" value="XP_038068014.1"/>
        <property type="gene ID" value="LOC119737622"/>
    </dbReference>
    <dbReference type="GeneID" id="119737622"/>
    <dbReference type="OMA" id="LCATHIK"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="940"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="968"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120974" checksum="4B89EC20A8DEA22A" modified="2023-02-22" version="1">MDQDSSDEEDVFSCGRCKENFSSMESFMEHKKSQSCRKARHRPMESQQQKQSPPSGMPISLSGRVAEDSIQETIQESTSSMDAQESGLNPVLAASDPEYSPQSSVARLQDVLTMLQGGQQVVQLDISSGGSEPQDGQSLMHVFERILTSSQNANLPAASAGTVNQSSVDGDTADNLPAQEMPRSDLSDIPSTSRESEDITSETVLTVPAEGESLGEEDSIQAGAGLGQKAIPGERNNGSGSVACSMEERPRQKQRSGRQRLPRGTESKDGSTERQEVQAESSFLSKIPAEHVDTTEVVMCKFCTETMTNGDDLFSHYMEVHKMKSGAALEFLRQSAFKKRRGRGRPPKRLAGKRCKPICCPHCGVSFNSKTLCAAHIRKHHRDKGTSSASKATDFPSGRRRKCSRCGFQTTTAKGLTAHIHSSHSNKAQKVAKVSETISIKTTQSESKPKTQRGRKQLRRPKEDVVTIEQDVFSDDINSCDVDDNHQEEAEDDEEHEMEDGQETNNASGKAQVKCPECNKKMCQQGLKRHQVRCVNKNRYICPLCQHKSRESYDHTVHVDNHKLWVKTQASWLDDKSTGSKPEATVTTEAAASCIDITPPLVPMDSNSIQSDADKVDYATTVDLDTLDLITQIQGESNLLQQNQLLLASGSSRHAEQDLQKSEMSGVSLLPEGADTDTGETHVSPSVEQEPKCIDGGDKKLNPRDLKCKICYTWFSRTSLPKHMLQVHSLVKRFQCRETSCKLIFAKLEDFKTHVASHSTENMFRCGCRGCVKRRLITPETMDNLRKEKMRDYYKHMSHKCSKCWVKFPSQGSLDRHMKRESHIHPCNVCGKIQVSKRQLRMHMVTHQAERAYLCEVCGQNFKTKRDLNKHTFSHNNIRPYQCPNCAKCFSFRNKMNRHMVTVHSATKPYTCDWPGCDKAFSRKDKLADHYKTHLVSYPFKCQYCTKGFYRKDNLKDHEILHTREFPFRCVDCNRGFMRPKILERHRLTDHAAVTTQITLQASITQDAQSDSPAQSISYVLCEPYVYANIDQLTSFQDNVQEADVQLMQGQRATIEAIQNAAAAVIGNGQAQFQIDHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY83</accession>
    <name>A0A914AY83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038068662.1">
        <property type="nucleotide sequence ID" value="XM_038212734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212734.1">
        <property type="protein sequence ID" value="XP_038068662.1"/>
        <property type="gene ID" value="LOC119738019"/>
    </dbReference>
    <dbReference type="GeneID" id="119738019"/>
    <dbReference type="CTD" id="51645"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="163" mass="17841" checksum="8D162ADFF115CC62" modified="2023-02-22" version="1">MSSANQEPAFVVLHTSMGNIKVEMYWLHAPKTCKNFVELARRGYYNGVIFHRIIPNFMVQGGDPTGTGRGGASIYGRTFPDEIHRDLVHSGAGVLSMANAGPNTNGSQFFITLAPCQELDGKHAIFGRVAEGLGVVKRMGMVDTNTEDRPTEEVKIMRAYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1H7</accession>
    <name>A0A914B1H7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069847.1">
        <property type="nucleotide sequence ID" value="XM_038213919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1H7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213919.1">
        <property type="protein sequence ID" value="XP_038069847.1"/>
        <property type="gene ID" value="LOC119739085"/>
    </dbReference>
    <dbReference type="GeneID" id="119739085"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="446" mass="49407" checksum="5A380A3FB93D81F2" modified="2023-02-22" version="1">MEVANKDVENLRNIGNQPDSPSGTVVHKMQGTPPLQKNREKPPTQATREASGPVSKPRKRCWCCGACQAPTSCPFQKEKGALNFRIIPSGSASAADIEKDRDEWFKAIRFACGDRRDSVAIFGTDDTINKTSMSASEESQPTRESFYQAMRHFQEELERLSLVINNIDERGDATKALIQLQQKARVIETMCSQIRPSSDASFSGISTSVDTESSSHLDQSSTVTLDTGDQSYDELLPPLIKSDRHSLIIGNNWVLHNNSSSGLTNGHSLIVDPPETNGEIQNGYDTHPTNNLEQRTNMIVNGITSCSSGNLSAVFECKCLRSKEVTCKNIHNSNMNAFVNGHEKCPETTAFVNSNQVTANMFLGFAPTRINELPPLPPPPPPILGKLDFMFWGLFLFLFCFVLFLFISLHFFARISSTEHAGLSALMRHLIGFKVLFCIILHRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1P6</accession>
    <name>A0A914B1P6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038069828.1">
        <property type="nucleotide sequence ID" value="XM_038213900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1P6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213900.1">
        <property type="protein sequence ID" value="XP_038069828.1"/>
        <property type="gene ID" value="LOC119739064"/>
    </dbReference>
    <dbReference type="GeneID" id="119739064"/>
    <dbReference type="OMA" id="YFICALQ"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="240"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="454" mass="48972" checksum="D719D6D831EBC8B0" modified="2023-02-22" version="1">MRSTIVAQKRSRPIPAEGGWGIVVVIAAHLKLAFLFGLMRGFGVLYLSWKTEFEASAKETAAVQSLITAVSCFSGAGLGISFNAGLVAVAMYFKRKYKVAHAVAFSGIGTGIMALPPVFQQLLDSYGWRGAVLVISAIVANVVVCGALLRPRYRRRSRRTETSHDFKKHDNVSGDSQEGITDIDHDPICDDESRSVMVTCSDSVDPQDGCTIPCRGPEIQTDKLHPVCEKSPVIKHLKRVSSELGLNIFLQSYRFSLLCLTLFEFSGPYAAFAVFIVPRAQSISKDGPVGTGVVTPSRAAFLISALGIGSLVGQLGNGLLISWKISAVNVSAACLFLCGVSSLLINADEYAVLVVASIVQGFSTGAFYAITVVLTRRFVGMGYFAICTGLFHIFMGVGMLSGPILAGWLFDETSSYNSVYYMLAGIYFICALQMLLVPLLKRLEPGMDIKPLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1X3</accession>
    <name>A0A914B1X3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="RefSeq" id="XP_038070350.1">
        <property type="nucleotide sequence ID" value="XM_038214422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1X3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214422.1">
        <property type="protein sequence ID" value="XP_038070350.1"/>
        <property type="gene ID" value="LOC119739459"/>
    </dbReference>
    <dbReference type="GeneID" id="119739459"/>
    <dbReference type="CTD" id="353"/>
    <dbReference type="OMA" id="QAYDLEY"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="179" mass="19422" checksum="7541C0E13F77E9FE" modified="2023-02-22" version="1">MGDENTRISRVKGAITAIQDFPKPGVLFRDIFPLFKDPAVLSDAVSLMVEHIKDKIGSVDVIVGLEARGFLFGPMMSVQLGCSFVPIRKKGKLPGKCVQASYLLEYGTDIMEAQAEAIKPGQKVVIVDDLIATGGTMSAAVELISKMEGRVVECLVLIELLDLKGVAKLKHPFFSVLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2Z1</accession>
    <name>A0A914B2Z1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069866.1">
        <property type="nucleotide sequence ID" value="XM_038213938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2Z1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213938.1">
        <property type="protein sequence ID" value="XP_038069866.1"/>
        <property type="gene ID" value="LOC119739109"/>
    </dbReference>
    <dbReference type="GeneID" id="119739109"/>
    <dbReference type="OMA" id="QRECEYY"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF1">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="28046" checksum="C9525CF4C13D4BAC" modified="2023-02-22" version="1">MAPFTLRCSSCAVVSSSGTLLGQGAGQEIDRHSCVIRMNMAPVEGYQNDVGERTSLRVMNFFMFNVNPYELPPNSQIMVWGLLPRKSHLENAQTLMRSLSAGSTIYGQTMQGEIEADQLFAEETGRKREMTNSWLSTGWFTLMIALEICQETHVYGMVPSYYCTMNGTADVPYHYYDSPWNKQCATYKDSETNSKGAHRFMTEKAVFARWAVKYNLSFHHPEWTIDRENLTRLDTPFVRSTLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3B1</accession>
    <name>A0A914B3B1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070403.1">
        <property type="nucleotide sequence ID" value="XM_038214475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3B1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214475.1">
        <property type="protein sequence ID" value="XP_038070403.1"/>
        <property type="gene ID" value="LOC119739500"/>
    </dbReference>
    <dbReference type="GeneID" id="119739500"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="8123449at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="274"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="575" mass="63479" checksum="1C3E25DB5E623368" modified="2023-02-22" version="1">MALYGDDLDVEALLEAPYKNNEGEATDKNGVSEKKESSSKKKHRSSPSRSPSPSPAASKEKHSSSSSSSSKRSSRRRSRSPEKKRRSRSRSRDRSRYDRDRDRPRERGRGTGRYGRRRSPSPPRRGRRSRSKDRSPNRDPFHWRRSRSRSRDRYGKRGSSPGRKKDIEPPPETRDARTVFVMQLSQRVRAKDLEEFFSSVGKVRDVKIISDRNSRRSKGIGYVEFMSDESVPLAMGLNNEKLMGVPIVVQPSQAEKNRLAQSNQTLQKGGAGPMRLYVGSLHYNITEEMLRGIFEPFGQIDSIQLMTDSELKRSKGYGFITFHDADDAKRALDQLNGFELAGRPMKVNHVTERSDNAQAASALDNDELERTGIELTTTGRLQLMAKLAEGTGFQLPNAVVEALNPLSNVPAIPGIPQGLLPSVSQVSLQAQLAVAQQQAAALANQAAPTASAVMPGAPAAAAASNPPCFMLSNMFDPTSETSTSWETEIRDDVIEECNKHGGVLHIHVDRSSPQGNCYVKCPNSQIAMAAVNGLHGRWFAGKMITAAFVPLANYHAIFPESAVVTTLLQPSLKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B3Y7</accession>
    <name>A0A914B3Y7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070519.1">
        <property type="nucleotide sequence ID" value="XM_038214591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B3Y7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214591.1">
        <property type="protein sequence ID" value="XP_038070519.1"/>
        <property type="gene ID" value="LOC119739611"/>
    </dbReference>
    <dbReference type="GeneID" id="119739611"/>
    <dbReference type="OMA" id="EDRWREW"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="565"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="981" mass="111173" checksum="415A76CD090F39F5" modified="2023-02-22" version="1">MATLQKLLWSGEYSDFCDEVVLVESRFVLERKHGECLCMVHAGLTETVFLIAEEIVDTNARHLRTVVVATDAPSNLEYLHLAHLFPLQNTRLSNRKHQEHRGEHVLRLRLSTGKTWFLELAEGRHREDRWREWLSWIHDLDERRHEKRQHPLSIEATRAPRANGNLDESTVDSQDSAAALAVAQQRKRRESRAYHWVGHFGGALSRDHDGQIAADDHDTANIGLPDHLLEHSTHEDLSRSTVKHGQSQKSAAVIMNPTASLVWQPAGNQHSLVMRKASYSSSDTYSSLEDIKSVGSLVGETNFDWMHPVSDEINRKLILCVEDLFQKFNMEAHGHGHVGRWRPLASLTAVDQLREADITTPHGERRGLPPIPTKETLHHRCSLPDVLEGEASFLDDMQPAADAAHRASLVYQDLVNDDETKTPHVIGGHVMLLSTEQTRLQEEIARCREMSADVEFSDGGGKMPTVTYGKGRAGISGRAGKKVPGEKTPPRHRRKKHEKSLKGKLQPEKHDSRNKPRRKQHAEGKLKSEHAEHFSTRILHSIWKRKQAKLDHDKPQQRVGVHEIDTEVLARELTLLDSLLFIRVREAELVDCLWLKEDRHTRAPHTTRLIEFFERVVGLVSTETVRPSTVKERAATVARFVLVAERCRQLQNFHSLKAVLSGLKVLPVYRLRKTWQAFEEDFPDEYGLWSELVFLTADDGRSDLYKMAVRKSLLSPPCLPFMGTFLLSVVDLYSAVDRAGMQPSHRAHMSSSSSSTHCFSSTDEGESTMHVIHFDTDDTVNSAIQTTESRTQPKPTHPAGFFGTFALALHTFRHKHVRPSHTTAEIHPESSDSGDMETNRAARGMTSTRKTHIRRLIIDYARRCAKERGMAWRAGVETVTVQDLLGAAFLAGVGSPINWGSLFAKVQPTGMPTVSKKEEEEKEAKKNAEYQLFETLFTHQMAAVQYRHKSNRAVRNYLLHAEYNTDQQNFKLSMSRESPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5K5</accession>
    <name>A0A914B5K5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071224.1">
        <property type="nucleotide sequence ID" value="XM_038215296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215296.1">
        <property type="protein sequence ID" value="XP_038071224.1"/>
        <property type="gene ID" value="LOC119740094"/>
    </dbReference>
    <dbReference type="GeneID" id="119740094"/>
    <dbReference type="OMA" id="WYYFEPL"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="129" mass="12390" checksum="E586E9921B5D0A69" modified="2023-02-22" version="1">MYVWYYFEPLNPGPNPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDPGPDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6D9</accession>
    <name>A0A914B6D9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071027.1">
        <property type="nucleotide sequence ID" value="XM_038215099.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071028.1">
        <property type="nucleotide sequence ID" value="XM_038215100.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071085.1">
        <property type="nucleotide sequence ID" value="XM_038215157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6D9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215099.1">
        <property type="protein sequence ID" value="XP_038071027.1"/>
        <property type="gene ID" value="LOC119739946"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215100.1">
        <property type="protein sequence ID" value="XP_038071028.1"/>
        <property type="gene ID" value="LOC119739946"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215157.1">
        <property type="protein sequence ID" value="XP_038071085.1"/>
        <property type="gene ID" value="LOC119739981"/>
    </dbReference>
    <dbReference type="GeneID" id="119739946"/>
    <dbReference type="GeneID" id="119739981"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22522" checksum="A6C0E19641DB8A6E" modified="2023-02-22" version="1">MKLYAITVLYKGQPKVVSLSSAYNLTSFGYFQKSSVQEFMKFTSRIVVERTQPGLRSTVKEQEYNCHTYVRSDCLSGVVIADHEYPSRVAFRFMSKALDEFATEVSPSTWPSAAENSITFKKLEEYLALYQNPSQADPMMRLQSDLDETKVIMHDTIDAMLQRGEKLDDLVAKSNDLSVQSKTFYKTAKKTNSCCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6V1</accession>
    <name>A0A914B6V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071545.1">
        <property type="nucleotide sequence ID" value="XM_038215617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215617.1">
        <property type="protein sequence ID" value="XP_038071545.1"/>
        <property type="gene ID" value="LOC119740345"/>
    </dbReference>
    <dbReference type="GeneID" id="119740345"/>
    <dbReference type="OMA" id="TRDMRQS"/>
    <dbReference type="OrthoDB" id="5981530at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000181">
        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF74">
        <property type="entry name" value="LP13728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037343381" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="13">
        <location>
            <begin position="31"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="511"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="796"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="866"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114070" checksum="941B6F98C6A1D4C5" modified="2023-02-22" version="1">MKVLPRVFTSAPYRIFLTCLCILRLPPVSGDDGMSPVVPLLAENDDDQIPTWAQSSVGPTETEYVPCPRGCTCSPLDKEALPSYAVECSGEDITSIDQMELPEKTVHLFLTDTSLEKLSAENFANLTFLNSITLKQNLKLRTVEPGTFNNLNGLTAIVLTHSPLLKEIGPGVFGDLPRLTSLSLDSCGLESAPNLTTLHPNDETLKKLVLSNNKIFALKPHTFSGLSFEVYNLDLSYNDISSVYGKVFEGASIVKLVLSNNPITYIEDNIFEGILDLREVHLAGTRISKLPTLGLKNIIVLDIENTPNLKHFPPLFKFENIQTARLHYFSHCCAFIYNTSANQHMAKMHNIMEPRDNSSCSTTPNPSSEADDIRDSSKPRFSTAHLVEDDFFQDPKSSLSRGSSVNLSSISHFQPPPDSLLTNAPSNMQPSVEEFDPNSGFIDNSGFVDQTIDPNITHKTHGDSCGPIVPKDYSKVNCSPRPDAFNPCSDVMGYSFLRVVVWFIASTAMVGNLIVMVVLIAYKRKMTVPKFLMCNLAFADFCMGIYLLIIASVDVYTLRVYFNHAIDWQFGAGCKIAGFISVFSSELSVFTLTVLTIERWYTIIYAIDLNKRIRLRQAGRILLGGWFFAVIIASLPFFGFAAYGVTSMCLPFYVRTTDGAASVAYVIFILLFNALAFIVICACYIKMYVTVRNPHSAMQRKDSKVAKRMAVLIFTDLACWAPIAINGLSSIFQDQKHGFLTTDQSKVFIVLFYPINSCANPFLYAIFTRAFRRDMFLLLAKHGMCEKRAMKYRPTCTSSPRSMSQVNSTTMRDVNPKGSHRGSSASVMTQITSEARPSMVSYDKDSPDNSPKMNIELQLVVTMGSNSHQNQPTVDMSQNQWDAPPLAPIASNKVGGSKKPNEHVYVVDGLPPVPEELNGDRNEIPSYSPTSKSKQGENQRLCRRQISPRIVEHCITDDNSEDNSRSKESSSLLPQVEWDQESSKETRKNSRADSGIQSVSTTPTDRDVTCKAMQMNLGRSDDFETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7H6</accession>
    <name>A0A914B7H6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038072123.1">
        <property type="nucleotide sequence ID" value="XM_038216195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7H6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216195.1">
        <property type="protein sequence ID" value="XP_038072123.1"/>
        <property type="gene ID" value="LOC119740774"/>
    </dbReference>
    <dbReference type="GeneID" id="119740774"/>
    <dbReference type="OrthoDB" id="10056126at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113154" checksum="39726C252A627770" modified="2023-02-22" version="1">MPGSLAPDHNFTAFQPSMAPYHAGIHNLYHETSPTLGTNPTPTQVSASTARVSDFSEPPTFNSSSQMMLSSMLAASAGGINTEVPNFGGGDPAEFRCFEAMIDGCIKPLVHLSELQKYFIVRSKLSGQPKKDVLGLEHDGSPFTKAMSTLKKLYGDVGVLIRAKIDQITSWPRLTASDSKGMVEFAAAVSALVKQLKSAPEGQAELNANSTACILYSRLSHTHQTAFLKAMKARNVNNFSLLDIDMWLQDTAAIARKKVQLSESIKVELPPTNRDRRRKGAAAYHMELAGKTTSNPPKGASAYKATRSEGKKPFRKSCPHCREEHWLSRCDKFSDLTMEQRMKWIKADKRCWQCARLHKNGKECDLRKPCRRCDKMHLTVLHDLIEQPGYGVYYSSFDPNLSVFYGDGNPWLPDVSMKILPVTLYANGRQLETYCLLDDAANFSLMLSEASEALGLKGESTKMPIATAREECTPCKGVIVSVDLAHIHDQDSRITISNVFSSSMLRLSEHSVPARDLQRRWPHLRGLPLQEVKEARPLLLIGSDRPDLIVPIESHFGPEGAPVAVRTKLAWAVQGPILKSRRKNEVNFLSVLPPMEADRVLHENVCKMWQHDAQMYLDRKQATRSKQDQRAIDLLEAKSTYVNVDGIDRVATPLLWRRDNEVLTCPASAVSPALKRNEQRLQRDPALAVEHSKKIRELKEAGLVRMLTAEEKERNPERHWYIPHHVVRQNGKTRLVFNCAFPYRGESLNDHLLPGPTLGSPLVGVLVRFRQHQVAVSGDIKAMFHCVRTLECDRCMLRFLWRDLDPDAEMEELEWNVLPFGTTCSPCCATFALHKHVQDRFPDPDIVRSVMNSFYVDNCLDGKSSVLEAKALVGKLCQALGAGGFPIVKWASNFAEVVKDLPQEARSCSTERWLSSSCDSPEEAALGPHWNFQHDTLRYKLELREWPVLTRRAVLSDVMRCAGKDPLGYPMPYMVRGKMLVQELWKRPWGLDEEIPDEGRMAYVPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8U1</accession>
    <name>A0A914B8U1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PrdX deacylase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072247.1">
        <property type="nucleotide sequence ID" value="XM_038216319.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072248.1">
        <property type="nucleotide sequence ID" value="XM_038216320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072249.1">
        <property type="nucleotide sequence ID" value="XM_038216321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038072250.1">
        <property type="nucleotide sequence ID" value="XM_038216322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8U1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216319.1">
        <property type="protein sequence ID" value="XP_038072247.1"/>
        <property type="gene ID" value="LOC119740864"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216320.1">
        <property type="protein sequence ID" value="XP_038072248.1"/>
        <property type="gene ID" value="LOC119740864"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216321.1">
        <property type="protein sequence ID" value="XP_038072249.1"/>
        <property type="gene ID" value="LOC119740864"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038216322.1">
        <property type="protein sequence ID" value="XP_038072250.1"/>
        <property type="gene ID" value="LOC119740864"/>
    </dbReference>
    <dbReference type="GeneID" id="119740864"/>
    <dbReference type="OMA" id="AGAHTKN"/>
    <dbReference type="OrthoDB" id="424586at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04335">
        <property type="entry name" value="PrdX_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.960.10:FF:000005">
        <property type="entry name" value="Putative prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423:SF3">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="YBAK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YbaK/aminoacyl-tRNA synthetase-associated" evidence="3">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="173" mass="19198" checksum="D346BF3736CDBEB8" modified="2023-02-22" version="1">MAASGNHGSKEELVAELKRLGIETETIQHPEVFTMEAMMPYMKDISGAVGKNLFMKDKKKRLWLLSARHDRAVNLAKLAKTVGARGLRLAEESILQEKLGVSQGCVTPLALLNDKSGDVTFLLDSDFTEGGHQRVFFHPMTNSETMGMAPEDFVTFLKETGHEPIMVNFDAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B943</accession>
    <name>A0A914B943_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072646.1">
        <property type="nucleotide sequence ID" value="XM_038216718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B943"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216718.1">
        <property type="protein sequence ID" value="XP_038072646.1"/>
        <property type="gene ID" value="LOC119741055"/>
    </dbReference>
    <dbReference type="GeneID" id="119741055"/>
    <dbReference type="OrthoDB" id="9925886at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="229"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="422" mass="46883" checksum="DA9E93D98E29ECF7" modified="2023-02-22" version="1">MYLSNEVFLLQRDLTQHIRCPVPREDDQFEWTRDVLREGDWHPTLVARFSSPESGTNYTISDHYGLMPSSHDLIIKNTKLSDEGVYHCGPSGKEFRFEVSVLDTTFPVFDDILRPSNESLMLPRGQMHIINCPVTTALDISGHDTVYWTLDVGKENYTSVIGAVFSDGEALVTDAYQGRYNINEERNLVVNSLEGAENRYWCNVFKIPHGLSTGYIDVTGKVTTQQEFPYISGCDKSEVECSIEVDQITSLNCSVANLYPMANLSWSLSGCEAGDRPPFLTNTSSVFDPGSETFNQSQELTISGNTTFRCTFTCEASGLSIANSSIAKSVNVTWKEHNVIEQGNPIGIALAIALPLLVLVVVVIPIIIVVCKKKRTRTENRHIRYTKPQGEENGVSPSKKDDRDDNAADGAEPLCLRPLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBN0</accession>
    <name>A0A914BBN0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073434.1">
        <property type="nucleotide sequence ID" value="XM_038217506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBN0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217506.1">
        <property type="protein sequence ID" value="XP_038073434.1"/>
        <property type="gene ID" value="LOC119741667"/>
    </dbReference>
    <dbReference type="GeneID" id="119741667"/>
    <dbReference type="OMA" id="DACAYIR"/>
    <dbReference type="OrthoDB" id="6608729at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="547"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="854" mass="98150" checksum="C03579B1DF1D21C4" modified="2023-02-22" version="1">MDDICDSVHTVNEAKKLTSEIDEVLAEGGFRVKGWLSNKALEENYNSDKEDERMKFLDTTTEEKVLGTVWNRKTDEFHYKVNLDLDKNLSTDDREVMQRKLTKRQILSQIAQIFDPIGFAAAFLIRYKIGMQQLWQQGLDWDQEIPKADHDRWIQLFKEMKGLNEISFKICLTPSNAVGVPMLCIFCDASEEAFGACAYVRWQIYDGNYDVRFVAAKSRVAPLKRLTIPRLELQAAVMGTRLYQAIMEEMRLPVKEAVFMTDSMIALSWIRSQARGFKPFVSNRVSEIQSQTDPSQWRHVPGELNVADDVSRGVPVKQLTQRWKNGPEFLRFPEQSWPQEAERVNQIEVDKERHKTQAVFITTETQEVIDGKKYSSWRKLIRVTAYVHRFVQNMRAKMQSCVNKESKQGPLSPQELTEAANYWIIKAQKNLHKRMANGEFKSLSPFTDDAGILRVGGRLQESTMLYTTKHPALLPHDHHISILIVRNIHQQGHTGVATTVAKTRQRYWILKAHNLAKTIKYRCVVCREAEHKLETQIMADLPKQRLAPYTPPFYFTSCDYFGPYQVKIGRNKTAKHYGVIFTCLNTRAVHLELAVDCSTMEYIQVLRRFFSIRGYPAKMISDNGTQLVGAQRELQKMIQGWNIEELKQFGAEKGMEWKFITPRAPHQNGCAEALVKSCKTALKRAVGAQVLTPFELYTVLLEVANLVNQRPIGRIPNDPDDGSYLSPNDILLGRASADVPQGPFQETQNPRHRVEFVQKIIDSFWKRWSRDVLPCLVPRKKWRAERRNVRVGDVVTVSDTNAVRGKWCVGRVLEVFPGLDGMVRNVKVKTESGEYQRPITKIAVIYPAEGYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBV6</accession>
    <name>A0A914BBV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SSUH2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073521.1">
        <property type="nucleotide sequence ID" value="XM_038217593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073529.1">
        <property type="nucleotide sequence ID" value="XM_038217601.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073615.1">
        <property type="nucleotide sequence ID" value="XM_038217687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217593.1">
        <property type="protein sequence ID" value="XP_038073521.1"/>
        <property type="gene ID" value="LOC119741720"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217601.1">
        <property type="protein sequence ID" value="XP_038073529.1"/>
        <property type="gene ID" value="LOC119741720"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217687.1">
        <property type="protein sequence ID" value="XP_038073615.1"/>
        <property type="gene ID" value="LOC119741788"/>
    </dbReference>
    <dbReference type="GeneID" id="119741720"/>
    <dbReference type="GeneID" id="119741788"/>
    <dbReference type="OMA" id="WAYEPYK"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46211" checksum="5A21565D03265686" modified="2023-02-22" version="1">MQQPQGSYPPQSGGYQQGGAPQGYPQPQGQGGGYPQPQGQGGGYPQPQGQSGGINTSATQPPAAATAPPSDNMDAIAGYGNFGAPLAPPSYDQSMMEPPQRSDLPNMPTVTVEQAREALLSHVAENCCYGKKAAQEMVFNDISHSSAFHYKLETFTEKRTTAWASEPFKGQMVDGPANGPAPGPWDMQCNPPAKFKNHKTAVEVPHTASVKPCHDCVGIGRKRCHSCHGDGNIHCHHCNGSGHVHSPLLHDDDHHGHHHHDNHVECTWCHGTGHQKCKTCHGHGQVTCGSCAGAGNLKVFIKLTIEWFNHLSDSIVERTSLPDELIRGVTGEVAFTEEQPRVWPINHFPDQTINQASKQLVQQHTTGFPLERIISQRHSVRVIPVAQAMYKWKETQGNFFVYGFEHKVHAPDYPQQCCCGCTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BC37</accession>
    <name>A0A914BC37_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073793.1">
        <property type="nucleotide sequence ID" value="XM_038217865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BC37"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217865.1">
        <property type="protein sequence ID" value="XP_038073793.1"/>
        <property type="gene ID" value="LOC119741917"/>
    </dbReference>
    <dbReference type="GeneID" id="119741917"/>
    <dbReference type="OMA" id="KKFAHEA"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="309"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="459" mass="50024" checksum="7D39F82A967D5AAC" modified="2023-02-22" version="1">MEILKKRKIDDCQSYPTAAVKSSTSPNHGVQMTCNPIPVLPREVTAVDFVKVYAAPILDPKTTSRIIRDLQRVYPLTTLPHVKRVRKTAKQQGGSSLEVILCLVTDVETTSSPASLSDIFRAKPSISQDGLGQPFVAMVSNMAPVTRQQFEVASREWPVVFHQNKQLNQVVSGQLFTDADKERIARHMMEAMVAARAGIHQEMVPVGAVVVDPSTDTVLASCYDIRHLNNSPLKHAVMVCVDLVAHSHGGGAWEVIAEGHYFRNQQLNKENVLGPEIDSHTSSSAPGHSTDEETRDPTVLSVEGSPVQPQDGRKSQDATEETSRCGIKTSDCANESGVQGSADRPRVDLNSAISSDSVGVKERNETGASAGRQGGDSSKPQGPYLCTGYDLYITQEPCVMCAMALVHSRIRRVFYGASHPNGALGSKYLIHCQSGLNHHFEVYRGVLEVECRQLHNGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCT1</accession>
    <name>A0A914BCT1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038074043.1">
        <property type="nucleotide sequence ID" value="XM_038218115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218115.1">
        <property type="protein sequence ID" value="XP_038074043.1"/>
        <property type="gene ID" value="LOC119742090"/>
    </dbReference>
    <dbReference type="GeneID" id="119742090"/>
    <dbReference type="OMA" id="HRTEAYF"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF40">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="11">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="751" mass="84261" checksum="13E26A66603A64CD" modified="2023-02-22" version="1">MGTASSARRAGASSGASGPPSNVVWINPRYGIRFGGDGGRRRRVRATPAVEERRSPTPPPTNTQLKVMSANLMERSNKFLHFTSDIDEVDGLVVRRGQAFKVQLTLNHPYDTSTDDIAFDFKTGETQNFQKRTRVLVSLREPRLSLAGGWKAEIETQEEKTITVSIVASPDALVGKYSLQVRTTVQSGDSTDPQRYMFKEPLPVFLLFNAWCETDQVYLEEEDERKEYVLNEKGFIWYGNWRQLGRRPWGFNQFEKTVFEAVMYLLERHVVDYERGSSVSVSRVMSAAINAQDDGGVLTGRWDGDYRPHARPTSWTGSQRILEEHFKTKAPVRYGQCWVFSGVFTTVLRCLGIPARSVTNYASAHDSDNSLSIDRFYDEDNERLERYESDSIWNFHVWNEAWMSRPELPAGYGGWQAVDATPQETSDGIYCAGPCSVNAIKQGHVYYPYDARFVFAEVNGDIVNWRVKRDRTTEVIKVKSSHVGKNISTKAVGSSDRQDLTMEYKHAEGSAAERAAVKTATSYGSKPGIYDSPENTEDVDVQLDFQDLFVGADFDIKVPLTNKSEEDRTVSITVIVQVVYYTGVLADKIKRIDETIRLGPGLNHQLNFKIDADEYLDKMVDQSAFKVFLLGHVDETGQAFAEEEDFRLRTPDLDVKLLRPAASEMKVGQEVEVELSLQNPLKKTLTNCEISVDGSGLLAPRVIKLSNLAAGGTLTKTVNFKPRKAGERTLVATFESDQLSQVTGELDLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BCY6</accession>
    <name>A0A914BCY6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073860.1">
        <property type="nucleotide sequence ID" value="XM_038217932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038073861.1">
        <property type="nucleotide sequence ID" value="XM_038217933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BCY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217932.1">
        <property type="protein sequence ID" value="XP_038073860.1"/>
        <property type="gene ID" value="LOC119741962"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038217933.1">
        <property type="protein sequence ID" value="XP_038073861.1"/>
        <property type="gene ID" value="LOC119741962"/>
    </dbReference>
    <dbReference type="GeneID" id="119741962"/>
    <dbReference type="CTD" id="89874"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="301" mass="33572" checksum="09CE890F075B5CCB" modified="2023-02-22" version="1">MSEAVTVGDRLKEGGRQILAGGSAGLVEVSLMHPLDVIKTRFQIQGGPQGVVYGTSMFDVVRRMYRTEGALSVYKGILPPILAETPKRAVKFFTFEQYKKIFLFGAPAPTPLTFTIAGLCSGLTEGFIITPFEVVKVRLQAERLQFSQQTSAFSLARRIIREQGIGRDGMFRGLTATLGRHGIFNMVYFSFYHNIKQYFPEASTPKLEFSRKFLIGLIAGTLASALNIPFDVAKSRIQGPQPVPGQIKYKTCFQTIRMVYVEEGYLALYKGLLPKIMRLGPGGAIMLLVYEYSYAWLQQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDT6</accession>
    <name>A0A914BDT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074388.1">
        <property type="nucleotide sequence ID" value="XM_038218460.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218460.1">
        <property type="protein sequence ID" value="XP_038074388.1"/>
        <property type="gene ID" value="LOC119742514"/>
    </dbReference>
    <dbReference type="GeneID" id="119742514"/>
    <dbReference type="OMA" id="HEYCCVL"/>
    <dbReference type="OrthoDB" id="406708at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037458520" description="EGF-like domain-containing protein" evidence="9">
        <location>
            <begin position="32"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="698"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="737"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="776"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="817"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="853"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="894"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="934"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="972"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1376"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1417" mass="149872" checksum="9B5ADF3BFDBDEE2D" modified="2023-02-22" version="1">MMFSADGKLRGVGILAVLGALVALQSGTVSGQPFVTPSRSPGHSPFPPASVPPSASSVCVPGYCENGGTCYGVHGIAVCVCPSSYVGMRCQVFDVCASSPCMNSGNCDLSVLPGPVAAWTCGCLAGYTGSYCQTATTSNTQCTYLQCQNDGTCYHDHMGAYCICTDDYNGPNCESVHQCNMVQCQNGGICNADHGEPICLCPSGWWGRTCEAVTLTDPCSILNPCQNGGTCYSDMNIVYCSCNMSYVGINCEFAVSGVHVCDSSSNPCQNGASCISYGDDFYCQCSFGWYGHYCVTSISPCANYVCLNGGTCSLTPSDHPICDCQPGWQGIDCSDPASTVDPCDTFNCSGHGVCTSFHTYAFCLCDNGWNGDHCENAYMDPCLSNPCLNGGECYSYGEDYISCYCSVGYGGERCETLFPTSCAELQCLNGGMCDDFYGSPYCICSSGWLGVNCSIADAACDNNPCLNNGSCESLWGIAICSCPPRFTGYNCETELDVHVCDSWVTSPCENGGTCQRLTGGTYLCRCPVGFTGINCSISMSPCSSNPCHNGGSCRVEAGDHVVCECTYGYSGVFCENEDNSDSCQTQPCQNGGTCYSFSGDSYICLCSSGWTGTDCQTIAGEPCDAFTCYNGGSCYPMWGVAFCNCVGNWTGYQCETAYQPDLCDTYACNNGGYCYEYNGRAYCDCWYDYTGEHCETEIVDPCDSVYCQNGGYCYSYYGVAECSCLSQWTGERCETEIVDPCDSVYCQNGGYCYSWYGVAECSCLSQWTGERCETEVADPCLTFNCTNGGYCQSSYSNDYAYCQCPPGTFGLHCEILLDDNCAADSCDNGGTCIDLGFAICLCPVAWTGFQCEFESPCASYPCQNGGLCLPSYSASFENFTCECASGYVGPTCADEHPCTSSPCQNGGTCIPGQYLEADFTCQCRHPFSGQTCETHVDCLGVTCLNNGTCYINVQNEAKCNCMTGFTGTSCETDIICDFVYCRNGGTCVGHGQARGTCMCPQGYAGQFCGTDLVCVDGACLNGATCVNIGSGQYQCQCAPYFSGRQCEVDSVCENKNCLNGGTCNNIGYGRAVCECPAGYSGTRCETDLVCVDGACLNGATCMNIGSGQYQCQCAQYFSGRKCEVDLVCVDGACLNGATCVNIGSGQYQCQCASYFSGRKCEVDSVCANKNCLNGGTCNNIGYGRAVCECPAGYSGTRCETAIGCAANDMCGSHGACKTNTNGKAVCVCNNGWSGDFCNKEDNKIDPNAQTGDKPASVGLIVGGAAMGLVAIVIIIILLALIYRTVHKRRPRTADNPQAGTGVPAPTPLYNTRFSIPGSQNQAGGGMAYYNANDNTVTGLPTGGAVGGDGLKPEKQQPVSLENPYDLPGHGAKAPQEQDTGYSNAGYQPDRPPSYTSRPTSADIDEGGYLTLREQNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEA4</accession>
    <name>A0A914BEA4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073757.1">
        <property type="nucleotide sequence ID" value="XM_038217829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217829.1">
        <property type="protein sequence ID" value="XP_038073757.1"/>
        <property type="gene ID" value="LOC119741889"/>
    </dbReference>
    <dbReference type="GeneID" id="119741889"/>
    <dbReference type="OMA" id="HAMLMMA"/>
    <dbReference type="OrthoDB" id="9989530at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="41760" checksum="560470A6973E13D1" modified="2023-02-22" version="1">MAAAARMTKEIQKIKDHPTKYPNISDSYQYSEQLFKDACLALHGIILQDIHLGKKELLKDPKFLQGRLYDTCTYILSRHEKDLEQIILEYEHPKLKYLRSRTMVQPKVDVMMAKRRPELVLVSALMIRKGSAGYEPDVREPRSDMARLAYMILERCCRWGFYLWVGTLKELRAFDLVYSFSELSQAKGTKSSQIVLKRDAILLPRVGKPLPSSFRKTLLVNRVDPEFCLRLYRVEPEMTMWEDKEEDVERLQDFYSSSKQLHTSYGTWGVFEQMQNVRRQVMKVRDYTDAAQYERAHAMLMMARVMFTDLVVVKKLDERDIDETDFLKRVMDKLKARIREGLRDREESSSEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEY2</accession>
    <name>A0A914BEY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 234</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073982.1">
        <property type="nucleotide sequence ID" value="XM_038218054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218054.1">
        <property type="protein sequence ID" value="XP_038073982.1"/>
        <property type="gene ID" value="LOC119742037"/>
    </dbReference>
    <dbReference type="GeneID" id="119742037"/>
    <dbReference type="OMA" id="LGEWYAE"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036926297" description="Transmembrane protein 234" evidence="7">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14185" checksum="29D0FF3C12B15E03" modified="2023-02-22" version="1">MNIMWEAVSLIAVALLWGATNPLMKKGGEGIQRVHRGNRIAQFGAELKFLVFNWKYILPFLVNQSGSVLFYLTLASAELSLAVPITNALTFIFTTLMGRVLGEDIGGKETYFGMALVVVGVTLCVWDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHL5</accession>
    <name>A0A914BHL5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075584.1">
        <property type="nucleotide sequence ID" value="XM_038219656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHL5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219656.1">
        <property type="protein sequence ID" value="XP_038075584.1"/>
        <property type="gene ID" value="LOC119743252"/>
    </dbReference>
    <dbReference type="GeneID" id="119743252"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32511" checksum="F055E5C1D0885DEC" modified="2023-02-22" version="1">MTRSYSRLSGPSLSVVNILSRSLMGRHFTTHYATANGIGTSGASVGLITVAPFTQLLLNTYGWRGTFLILGGFGLHLGVCGALLQSPPTDETKKNGEYQSLGPDIDEAPVINSPSAEETGNSKLSSRLITFKDAICAQMSRFGFSVCLRVPFWITAVIFCCSSFCGVQWYIYYISQAEAKGFSPYDAVTFTTAAGVGNLLIKILSGPIVDRGLLKLRPAIVLTIMLSSSALLITPLVNSYWLMMANASIFYGAFGAVVSLNDLYTRELLGTDLLACAFAWMELVAAVLCFSLGFFPGKTHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BIK6</accession>
    <name>A0A914BIK6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075735.1">
        <property type="nucleotide sequence ID" value="XM_038219807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BIK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219807.1">
        <property type="protein sequence ID" value="XP_038075735.1"/>
        <property type="gene ID" value="LOC119743412"/>
    </dbReference>
    <dbReference type="GeneID" id="119743412"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="86" mass="10141" checksum="7416E904FF1B77D7" modified="2023-02-22" version="1">MVTPLWNQPYEDQLSTKQTNSREFLRNLSKMLQRNIGEMSPWLKQQRKNHSRMACELEPIKPSPVLESYRNKCEFTISKSVDGIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJE0</accession>
    <name>A0A914BJE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038076025.1">
        <property type="nucleotide sequence ID" value="XM_038220097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076027.1">
        <property type="nucleotide sequence ID" value="XM_038220099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220097.1">
        <property type="protein sequence ID" value="XP_038076025.1"/>
        <property type="gene ID" value="LOC119744248"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220099.1">
        <property type="protein sequence ID" value="XP_038076027.1"/>
        <property type="gene ID" value="LOC119744248"/>
    </dbReference>
    <dbReference type="GeneID" id="119744248"/>
    <dbReference type="OMA" id="YLTPQNQ"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14061">
        <property type="entry name" value="STKc_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="116"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="595"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="752"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116337" checksum="110FAD7553B88F1F" modified="2023-02-22" version="1">MSPVGDRTSMGTMDPLQSVPESPGASKKHESKENGTSLCTVIYDYEATAEDELTLHRGDLVEVISKEVSVSGDDGWWTGKVRDKEGIFPSNYVSQPHVLLQKEKNFGVTEINFDDIVLSEVIGVGGFGKVYRGICAGEEVAVKAARTDTEQDLGEIMDNVRQEAKLFSLLSHPNIITLKGACLVEPNICLVMEYARGGALNRVLSNNCKKLGLPPDVLVEWAYQIAEGMHYLHSDAPIPLIHRDLKSSNILINEKIVDNDFYGKTLKITDFGLAREMYRTTRMSAAGTYAWMAPEVIKSSLFSKGSDVWSYGVLLWELLTGEIPYKGIDGLAVAYGVAVQKLTLPIPTTCPEPFVRILEECWNPEPHQRPSFPEILNHLREIQDSPFIDTPHESFRSMQQDWKQEIQEMFDEIRLKEKELRTREEELMRQNIEQQCHARVLRQREQELAEREIDLLGRELNIMILQQQQDDKPVPKKRRNKFRRGKVRRSNKRISGPSDFQHKLTVRTDPSYDRRDPRSPLSPEDSPPKSPLPRLRVIALPKGIKGKTWGPSSVQQKLKDRPFKAYSMSEATGKKFTNTSAPGNPHWYNTMGSTPHDNEAEWPTDIGLPKAHWPSVGPSTDDGESTDDSRTSPRNSLKRERKRTTASLYTMTAMLASVAMGFDIRTLNQSRQDELDFHHRKNSSASESYSRQGSLSFQHDPDDSPTMSRASTVRLISVTSTNDDNKHYLRQGSWQGFVDSSTNVTIKQNPAFNGESKAVAPSEPVQTAVKTHRRTASADNNLSYLSHKRTPSDSSSPSYSSFTSTVKWDGTDPWSSPESDVSRLPNPPQAPPRRISLVLPSETHAERPRTLDISPRPRPYPRAHLTPQPGSQDSPLGPSPAAASVTPKHSTHSSDVSLSSVTPSPAHHYQAAGGAEMQRSTATPSPAHYYHQGASELSRSPAHHYLPPHTPQHHQSPHHPHVGSQTPSHAAQHYTTPQHQPHHTPSHTPHHHRVLEHHPSLLDEDMAGQKADGTMPLVREGHETKPRKASVRELEEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BK53</accession>
    <name>A0A914BK53_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076489.1">
        <property type="nucleotide sequence ID" value="XM_038220561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076490.1">
        <property type="nucleotide sequence ID" value="XM_038220562.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220561.1">
        <property type="protein sequence ID" value="XP_038076489.1"/>
        <property type="gene ID" value="LOC119744575"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220562.1">
        <property type="protein sequence ID" value="XP_038076490.1"/>
        <property type="gene ID" value="LOC119744575"/>
    </dbReference>
    <dbReference type="GeneID" id="119744575"/>
    <dbReference type="OMA" id="KQDSTHK"/>
    <dbReference type="OrthoDB" id="10072022at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026139">
        <property type="entry name" value="GOLM1/CASC4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02084">
        <property type="entry name" value="GOLM1CASC4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="730"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="793"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="963"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1304"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1432"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1446" mass="166518" checksum="6B8B7ABD1E2952C2" modified="2023-02-22" version="1">MQRSKMASNGMSRGKTPQFLTFGLLVVICVLAFNYWNVSSRSKLLQKQVQEMTSTLEELAMSKIHLEKRSEALQMQITESNRLINSFRQEKDALGMQRQQCLLELDSKRTQNQQLTTNLNVCQEHKTDLEGQFQIKQGNLSVTAQLLQECKAKYDKLIEEDDLITAKRQEEMNNLRSQQGLLESNNRQCLEDKEVLNDRLNSIKAQVQTRQIEAQKCQESLNTCQNNVQNLQQQLRMTMQQQQQQQQQHEQLPDTNQQQQYQPQQQYQPQQQQQQQQYEQQQDQQQQQQPGTGQEQQNQVSMNLDLQQRHQQHLQEFKDRQQQLQQLVHIHPGKQDMQEEQQQTDQQQHQEYPGQQGQQQVRYQQYPQQQVEQDQQQQQQQHQEYQQQQGQQQVEYQQHPQQQVEQDQQQQQQTDQQQQQEYQQQQTADKLQQLEQEQQHVGQQQQLDTSKVVETGQEGANQKSQRSQQQSHSREREHDQLVNRQNKMEHTDQRQKEPQQQQQQQQQQLTNKQQLEEINQHGEQEQHHNKQKVTLAPHQQDGQQDLHQQEYEQQQKPMKQEGQQQGGNGQEEQQQEHQQQEELLSKEKQQQEQHTAQQEQKEQQQDKQQQEHKQQEQLTTEQPQQEDKEQQQDEEQQEPHSIEAQQAGPTLQESKQEQEQQQREGQQQQDKLQQEQQQQEQLSTVQNQKQDKEQQQDEEQQKEHSIEEQQEEGQQQEKLHSSEQKHEDQQQQGNEQQQQQEQPQSQDGQGQQQQPSEGKDQQQTPKPQQQQQQSHHHENDPGQPQKGGNVDVQNQQAYNQYLQQQQQQQEQQPQQEQQPQQPGAQDAEAQQRYILEQQELLQKEQHRQQLEQLQQHQDLQNLDGQQEPDNNERGVPLEVDRPQEAGQDHQDPGPVKMIENEEDQQRQEKDGQDEEVKKGEEEEAKGGEEEEAKEGEEENVARQDGGEDDNGGPAYQDGEEVDEGRKAQENDEARQEDLEKDMEMRMQRLRPQGDEEDRQKEQEDAGGDEEQPGREQDEGGEDRAEDRDGRPPEYGDDREEGDQGDEGRDAEEPNEGANVPVVDQDIQIEGDNEDEEVGNETWEAEQEQRQRQVEDGGPAVERPAFIYDQDADRMQGRDGGEGDGAGQGEDENGLKEEEEVGDPGEAEDVGDAGDEEDAPQDGEQQFDDGQEVEEEDAENPDDAENPDDAENPADDGNRDDAENPDGAEYPDDAENPDDDGNPDNDGHPDDAENPDDDGNPDDDGNPDDDGNPDGAENPDGAEYPDDAGNPDDAGNPDDAGNPDDAENPDDAENPDDAGNPDGVENPDDAEYPDDAGNPDDAGNPEDAGNPEDNGNPEDNGNPEDGEEQQEGHLELGDVEIEQANALSSNEAERNEQEQNQENYAYGNVNNAADYPDHDNNPDGGNDQEADAQENDIRHHYDAGDAQGNENLEEGRANDVYDARDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKJ3</accession>
    <name>A0A914BKJ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038076803.1">
        <property type="nucleotide sequence ID" value="XM_038220875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220875.1">
        <property type="protein sequence ID" value="XP_038076803.1"/>
        <property type="gene ID" value="LOC119744763"/>
    </dbReference>
    <dbReference type="GeneID" id="119744763"/>
    <dbReference type="CTD" id="65220"/>
    <dbReference type="OMA" id="QKAFKEW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="496" mass="54774" checksum="1470A5ED38AC4AD4" modified="2023-02-22" version="1">MGEIARIKGEISRCMSGDEDNGLLDGVGMDSPDAAVKVAPESASNHGSPAMPAKEKRRPLVKQSRSISQDNSNSEFHDGPPAELMALRRKSDFQRRRSPLERTRSINAPSPSPSFGPKAHLKKVPPSQIMHVTDPSGQRLVWKGTPLSVLIIKKIMDDSVLGPFKELSRWLSEEKNLLIYIESKVFDDEDLLNDKDFAPVRAKMKSFKEGVDLSNKVDFILCLGGDGTLLYASSLFQEASVPPVMAFHLGSLGFLTPFEFEDFKESVNMLLKGDAAVTLRSRLKCLIFDSSDIPNGFDNDRNDDPNQIIPPTPKKVDPPSLKFKFQVLNDVVIDRGPSPYLSNIDLYLDRRKVTTVQGDGLIISTPTGSTAYAAAAGAAMMHPNVPAILITPICPHTLSFRPIVVPAGVELMIMVSPDARHTAWVSLDGRNRQEIHKGWCLRITTSVFPVASICSADQISDWFDGLVECLHWNTRHQQKALNTPKRGDKNRNQVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMA2</accession>
    <name>A0A914BMA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_038077413.1">
        <property type="nucleotide sequence ID" value="XM_038221485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221485.1">
        <property type="protein sequence ID" value="XP_038077413.1"/>
        <property type="gene ID" value="LOC119745254"/>
    </dbReference>
    <dbReference type="GeneID" id="119745254"/>
    <dbReference type="CTD" id="9601"/>
    <dbReference type="OMA" id="FRSKHEP"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000107">
        <property type="entry name" value="Protein disulfide-isomerase 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000067">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000076">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000126">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF210">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038169962" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="56"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="183"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="526"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="568"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="659" mass="75101" checksum="4B91C49317293A11" modified="2023-02-22" version="1">MLPKNLFYFVALLGLILFSCPAARCEDEEAPVEVDKATEDDLKPGETVILDEDALMDMGDDEDDNEEPEVTEEDGVLVLTSDKFDDVVKNKDIILVEFYAPWCGHCKSLAPEYAKAAQTMKKADPPVLFAKVDATAEADLAQRYEVTGYPTLKIFRKGEASNYEGPRDEAGIVRYMKEQSDPNWEPPPEAVMTLTSENFDEIVNQAGPILVEFYAPWCGHCKRLAPELEAAAGVLKDDDPPISIAKVDATEEKDLATRFGVSGYPTLFIFRNGEKSEYKGPREKRGILEYMRKQAGDSSEHLASPKALKQFVEFQEDISIVGFFKTEEEDLYKTYLEAGNDLREDYRFGHTFDHQLMANYKVNPNSIVIFMPERFQSKYEPKRHVFDKAGASAAEIQSFYSDNDLPLVGHMTKENMDKRYKDRPLIVAYYDVDWSFEHRKATEIWRQKILAVAKDKEFKDLTFAIAEEDEFNDQLKQLELDDSGEEINIGLFTDGKKYKMEPDEDFDSDMLREFIRAWRDDKLRPIIKSQPIPRKQSSPVTVLVGKTFDKIVFDKRKDVLVELYAPWCGHCKKLEPTYKKLAKKYKDHPSVVVAKMDATANDTPSEYSSSGFPTIYLAKANDKKNPLKYEGGDRSIEALSKFIEDNASTLTTKKAKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMY8</accession>
    <name>A0A914BMY8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077101.1">
        <property type="nucleotide sequence ID" value="XM_038221173.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221173.1">
        <property type="protein sequence ID" value="XP_038077101.1"/>
        <property type="gene ID" value="LOC119744950"/>
    </dbReference>
    <dbReference type="GeneID" id="119744950"/>
    <dbReference type="OMA" id="VEWDGHH"/>
    <dbReference type="OrthoDB" id="5945029at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000610">
        <property type="entry name" value="protein HEG homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF373">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640633" evidence="8">
        <location>
            <begin position="25"/>
            <end position="3771"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="11">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="11">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1509"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1551"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="1977"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="2298"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2480"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="2524"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="11">
        <location>
            <begin position="2915"/>
            <end position="3003"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="11">
        <location>
            <begin position="3019"/>
            <end position="3108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3118"/>
            <end position="3156"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="3160"/>
            <end position="3338"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="11">
        <location>
            <begin position="3672"/>
            <end position="3766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1991"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1518"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2510"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3127"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3146"/>
            <end position="3155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="3771" mass="417203" checksum="1A62FC48F10F57C9" modified="2023-02-22" version="1">MARLKPRGWFALVTLLIAITRTEASVNMQTKYACEGEILSLDCGEKYIKVWSALYGRANPTICQENVMAPLPHACRADKSNFESIRHCDGNNTCEIRAENSVFGDACGSIKKYLQLEFYCRSEKSSECNPRDSPTYNTKYACDNTDLVLECPNPGDVIKILDANYGRQGSNVNCTYRPGVDDVFCDDDTGESFEHVCLECRGKTECTVPVSPQEFKDRCVNTNKYLSVQYVCISTEPEEEEEEDERETPQESEIPEDNNRPPPRPRPEPEGTTTAAPKGPIFFMLPKPGQVISGSIGSATGQSDTKTFTWNGGLEAPRPGSGNTGGSIGSGTDPGSENTFTFLRPGQAGTPGKNGIQGSIGSTRPDGSERSFTWGGEPFEGFTSLFAPVGAAPGSTELIMKIIVTTDASGQKYFTWQAVPTGATPGGAEYLMKIDLTKLAQYTQQFTFAQLIEEFNRGITFYNMYNKPSDVSPPFQFSIGKGLTAFFPSIFELITEVDATTGKTVTVPSPSSSNFQVLLDGGNRQIIEYLMSFTNMNQQLRSELLDHNLRIPLRYYDETTKQIEDIKIPFYVNYNGLTGSLSTVYNAMPKPTSQFGMKFQIIGEDGSRELITLPLTIVEDQGKKMLFLTLSTCAAYKMYGFGDDKEYLIDPDGINKGEQPFVVNCNMEKGETIINHNREESTVASYPAGQSRLNVDITYDGASAAQLAALKTVSETCEQELSHECVKTSAHFVGGNAKIWWQSFDGKKRENWGGVETDVKKCHCGLTDACKIKGSLCNCDNAEGTSDWGALIDKDTLPVSRVVFETPAATQGQDKLKVGALKCSGDQSSNTLKFFIMLMQMLARGTGGKILKTCDEYKNVGYELDGVYLIDPDGKGGEKPFTVVCDMEKQEHGVTIVHHQVSNQRTMVNNFEEPGSYSMDVSYGATLRQIENLKHVSGVCEQSVTYECQGSAFRVGDVQYHWWMSFDNEKIDPTCLGNSNCDCDKDDNVLRKDVDLLKDKNKLPVMQLRFGDTGGNDEFGYYTLGPLRCWDYSRKDVATRADLSSCEAIKKADPAARSGNYYIKVNINLERFLVYCDMSGTEGITIIYPDSVRTLEIDGFYEEPGTWARSIRYGPSEIQLLALTTLSASCKQFISHGCHGSLHHDDVTGKMYTWWQSRRGEKMTYWGDTKEGCQCYADKTCQVANQKCNCDVNSQSLSSDEGFLTDKSVLPVSAIRSGDVSDNNGWEYGTAKLGPLMCQGEQALPGVRELDSEPDCEPIITEDGGQYREMTGEQTLSDFEFSVRTPGTAILKLGVYSGPATAYYKIEIEPGKNVNFYRCNYNARQEDCSDKQTQSFTSAPSSATEDRKFILTFGTSGLELTENGESVTFQDRSIRTLPVKYFAYKTSGGDGQWLFDSICTGTVKVMCSGTDTLSCVAPMKPYIVKALYGRTERDVCEISNDPTDYPDCQIDVTKQLRNNHACLNQGSTCYYHASDNSYKSALINARCRPKKGYLHLVYSCRKELPQEKNLGACSSNPCQHGGTCLESDDEASYSCLCHEKFAGVNCETEMVTCSALGDPHYKNFAAHRFDFQGNCMYVFARDCKEDPDFEVLVVNQSPKLNTAVSSTAEVIVVINDRKIQLKRYKEILVDGERIEQLPEVDEDFSIRDRGAHVELHVPEYSLTVTWNHNDITKVILPKNDGSRDICGLCGNTRAFLSVGSYQMKSGTIVTDPVVFGNSWQADTDTCVANTDPRNKGQLSQAISVGQLVIARRFCKAISATNVAGCPNTAATADASRQSCEFDHASGLAEKACNIIKDYQDECVEEGGSIVSGGNTQCGAACAKHLEHTQCVMPCGTCASFRLLSGNCNEPCISGCSCPDGKYDDGDACVEEEECGCAYEGRYYKLGSKFLDATCTEECTCLQDNVVECGTPADKLCSMDNPELHTMCMLNDGVYECVCIRGYELNADKTACVAMQMNDLVYPPGRRRRRRDVSEAECNVELGMASGRIADNQISSSSSKNGKSLAKHARPNLSGWTPQRGDTEQWLMVDLVIPTEITGVMTLGDRHKVGRRYKQAWVSAYGVEIKLDSLDPWITVRDSNRREQFYGNTDTNTPVTNTFFEPVHARFLRIRPISFYGEISMRMEVIGCKQVCDAEIGTFPVTRHIASDNWFVVNTGEPITCMGQVTAWKVIHAREEPLEAWVLRPLKNNPDGFMLIGNTHIPAGPVDKEVEYELMGDQRIPVHTGDVIGFLYERNPLYSSEEGEETMDYKWLHIRDISNFESMKPGFSLRFTAGDGKRAFSAVAVLQPSNGVPVPPVQCAGEMGLSMDKIVIPDEAFSASSHVKGHKPTRARLNTLYSHGGMRSGWTPRRRDRKPYLQVDLGDQRHLSGIITQGRHLKENLKNFKADTGRKRRRMRRQKRRARRRSAWVTAYFVKYSLDCEHWEYIRTPDGQRQLFDGNVNPSTPKTNYLDEPVTARCIRIHPKKQRRSKIGLRLELLGCSVDPCTSSPCEQGGTCRQTSGLNPDGYVCQCPEGWTGTRCEIVEGMCRSAGDSHYNTFDGRHYYFPGECTYTLAKDCMNGDAPTFDVLTNNAAAGREIYIFTNDIMFEFKQEGVVHVDGEACRLPVKRNGVSVVHNAYTGVLLQTTYGLTVEWDGHHRVVVNLPATFADGVCGLCGNFNGNRDDDIPEGVSEMQYGETFASEPENCEVCEKCQLDKPYDSNPGRQSEAQESCSPIKDPLGPFARCHGVVSPDEIYDDCLQDVSDSDSLSSVPRCTQFAEYADMCSLNGVVITSWRKKNLCGITCPAGMIYTHCGSACPATCGDPHAPNTCTKPCEETCQCPEGLLKEGDKLCVPPSECGCTDNGCYFERLTTFYRSGCTERGFCGLNGEVMYEASQCGQDATCGSKDGVYGCFCNDGFSGDGLQCTDVQGDKALLTCESDVLNLDCGAGQHIDIVEAVYGRMEDFEKCPTKNQPKGECSSQSTMSVLIAKCQGKEECSVDVSSEVFGDPCYGVNKYLEVDFQCTATPKPKSVSEEVMKRVCQGDSMEIDCGNLYIEVLDAVYGRVTDGQVCPGGHIESVDCMATTSLAVIQQLCHGETKCTGLQAASHLFGGNPCGRTFKYLEVKYRCSSEVVQKANLPANPCAENPCLNGGQCVTQETSRGYKCTCPHDRTGPNCEFEEVSCRASGISHIMDFNEQHFEFLGDSKYDLATSCLENKNDFRVMIKKARMPTENSVSTIEAVHVHYDGKVIELKQEYKVLMDGKKVSDTMNLNFGKIRLCRVGNYLLLKTDFEMIVAWDGLHRVQVRMPDNVARQTCGLCGTYHGLGTENEGFIGKDGNKVDDVDAFGSSWRVAADAPAFVHTDLITMHPCSMWPSRAHEASVLCSELKNARGVFRSCFAKVDPGEYYRKCMYDMCATLPSQELLCQAMAEYADICLDEGIVIDNWRSSFREGQCEMACPNGQVYSACVQSCPKSCGDPHAGKEPMDRCYEGCMCPESGHLQDGDQCLTSDNCGCQRLGIYYQPEERVVNDQCTGQYICLPGGKWNENPLTCDANAHCGVVEYKQDCVCNDNFAGSGKQCFDAKHVTPKVASQGESLHIDCGDEYVDLISADYSFTDPSSAGATTDPDCRASNVMDVLANHISKDGKILEAKASAYHFGETCQQTGNVLTVSYMCSARPVVREVELGKVVHMRGCQDREISLKCHKGSRIKILKTEYGRQTGSEVCQSAYSQHILTTSCRASPKRLEKRVRRRCDNREECRIQIKKRKLRVNPCKETPKYLDVTYKCEAHEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP27</accession>
    <name>A0A914BP27_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038077456.1">
        <property type="nucleotide sequence ID" value="XM_038221528.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077457.1">
        <property type="nucleotide sequence ID" value="XM_038221529.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077459.1">
        <property type="nucleotide sequence ID" value="XM_038221531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP27"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221528.1">
        <property type="protein sequence ID" value="XP_038077456.1"/>
        <property type="gene ID" value="LOC119745284"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221529.1">
        <property type="protein sequence ID" value="XP_038077457.1"/>
        <property type="gene ID" value="LOC119745284"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221531.1">
        <property type="protein sequence ID" value="XP_038077459.1"/>
        <property type="gene ID" value="LOC119745284"/>
    </dbReference>
    <dbReference type="GeneID" id="119745284"/>
    <dbReference type="OMA" id="WKLANPR"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="651" mass="72355" checksum="0CD05ED0C554E7FC" modified="2023-02-22" version="1">MPPGRPNFAVCYICGRDYGTRSIEIHERECIKRWQLENDRLPPNMRRAAPQKLKVLPGITSGADRGSDMNRQNVAAYKSSQAQLLPCSKCGRTFLPERVKIHEKTCPAGRAPDTQRGQLGVRSRSRTEPREAAEDREGLSKSWGGSITQSDDSQPPRPTTATLIRPSTVTLKHRDLVTIDDQEYQITDDSFYHPHDESSITPLQDRSQTQRVSKPRPKSAKRGRQSNTGPVSSQPGTPSSQFRGTSSSRTAGSPLHPRPPSNPRPTPSPASTSKLAPIRGRPATVVCYICGREFGTKSISIHEPQCLEKWKVENNQLPKHQRRPVPRKPQPLGTRNSNAASADPDGYNQAAYQSANSQLLPCGNCGRTFAPDRLPIHERSCGRPKTTTLRSSNGLQASSNFGSSNGRQNMNNTGKPRTLVCYICGREFGTKSLPIHEPQCLQKWQVQNQQLPRELRRPLPRKPEVIGMQGGRSTGEMINEAAWQAHKANLVPCDSCGRTFAADRIAKHAASCQARTQGQERGNNSSQRPKSGGTRKIQMSKTATAVRRPQTVICYICGREFGTKSVSIHEPQCLKKWAMENERLPKELRRPPPIKPQERMIKGGSGQYNVDQMNEAAWQASQANLVPCDTCGRTFLPDRLMVHRRSCKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BP68</accession>
    <name>A0A914BP68_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078068.1">
        <property type="nucleotide sequence ID" value="XM_038222140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BP68"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222140.1">
        <property type="protein sequence ID" value="XP_038078068.1"/>
        <property type="gene ID" value="LOC119745634"/>
    </dbReference>
    <dbReference type="GeneID" id="119745634"/>
    <dbReference type="OMA" id="FRIENLC"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61846" checksum="CD76C349988BC7CF" modified="2023-02-22" version="1">MYRYRVLRKCLPIKTWSGPTVQWSRPKTALVEETAHSAFNKEAPETRRPFEEIPGPKLWPIVGCFPNYLANDFKPEQYHKMWQRRFEEYGKESKLVAERVLHRQWVNVYSPATAKQVFAQEGEYPKRPQMSLYYLRKEHLGHLGVALENGERWKKGRSLWNRKVLRPQSAEDFIPRLNDVVEDFVEHIRQLAAGGPREVNGQQLMPGEVPNLLTEIMKSALEMMGTIALSRRLGGIRPGVDLDLDAHRFMTENALLWPHSTKLDMSAFQLFRYFPSKTYEAMKGHWLNMCAITAKLMEEYNDSMKDTLESEEFTGDSAPDVYSYFLAKNTPAKELLGHMQDLLQVSMDTTSNSTNLLLYCIASNPRVQEKLYEEVSEVLQGGRVTANNLKDLRYLKCCVKESSRMFMTIPGTSRILDHDIALNGYNVPKGTYINLCFQTMCRDPDIFEEPHEYRPERWLDVRKAPDMAFSHLPFGFGPRSCVGRRLVDQEMYIILANLVSKFRIENLCDSEPDLKWIGINLTASEPLRLAFHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BPM9</accession>
    <name>A0A914BPM9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Retinal homeobox protein Rx</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078099.1">
        <property type="nucleotide sequence ID" value="XM_038222171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BPM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222171.1">
        <property type="protein sequence ID" value="XP_038078099.1"/>
        <property type="gene ID" value="LOC119745654"/>
    </dbReference>
    <dbReference type="GeneID" id="119745654"/>
    <dbReference type="OMA" id="PNHSIDA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000071">
        <property type="entry name" value="Retinal homeobox gene 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="213"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="12">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45493" checksum="BEE7717CB56EA4ED" modified="2023-02-22" version="1">MLSGLELCVCPATAAGSSDHVTAAPLKGMMEQQYRGASAPCPLDFPVVSHHQAVHHLAMNTQARYQQPPKPNHSIDAILGIQREAEADKHRTVLGPLHHHLPPSPTHRARSTSPTVAPCTPPPDNHVDGKEEETAFLEGFKSNKNGFAHKNSTRQATDSISQPRASAQHQSCGESTALGSTSDSAVELDEGTPDSPGSPGGADLGEDGPDGKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELALKVNLPEVRVQVWFQNRRAKWRRQEKMESSAIKMQEQAISSLHRSTSGLNTKLPLDPWLTPPMSNAAAPASFPSLQGILAHGHHQLSPLGSAGGGRGHLCGLGPISFPLLPPTSSSFSLLSPTLGGPGRQGVGLLETGDVRHSSIAALRLKAQEHLDTMIRAPVYSGQSSPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ19</accession>
    <name>A0A914BQ19_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exocyst complex component Sec6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078055.1">
        <property type="nucleotide sequence ID" value="XM_038222127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ19"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222127.1">
        <property type="protein sequence ID" value="XP_038078055.1"/>
        <property type="gene ID" value="LOC119745627"/>
    </dbReference>
    <dbReference type="GeneID" id="119745627"/>
    <dbReference type="OMA" id="CAYLELI"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="79649" checksum="309722D6AA52D63F" modified="2023-02-22" version="1">MQRELRASGIMKKTRRVQKKAGIGKKLPMFLFKKRKPSITIQMERRPSANQSDNLWRNYKKLQQLETWRDGILHDIHEELAGVDETNVETKIRKESFQGAEHESNSMFEQIRQVFMRLSSLKTYDRHLLETCIRIVDSEERRDNESTANGTEHDGPSVTPGRPKRWREKCLDVIKSEVSKRASETAPSHDILEEDKDGSRLLQRLTKARDAILKDLEHAKDLSQLFTEEWDMYNIYVMTYYENVMSQMHDRFSFELNQTETVQVLSWMILCRDRVFNCQNADCKPCQMIVQLQDKFLREKSVHIHEWMENALKRDISDWRSEERPTADHSGALYSHFPVDILQLLEENMRQAKDISLELHGQISKVCLKELDAIMESYTANAKSYINQDQAKPAQGGRAHHRVSPPLRHGARKNSKEQRPTHFEKYVVALLNNFDRITGRLREMTKEVGEAQKQLTEDSRNNNNMQLDEEPMQKLIQKVETQTKVCSRLLLPKLMNDINSELATLLTPNWLTGNGREAVDTMCDVMTSYLRHLREPVRTWLMPAIEEMLIVGYMKGLTDKRITLKGDMKDRQSLFDKICRECQQLEKFLEEFSVVNGQISRWDVVRELASLVQVSDQQTVNTELIVLANKYPDITDKQARHVLKVRGDFTKAQVKTIVSTSLGKKRRSVKGQKKVTIFSRLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQ86</accession>
    <name>A0A914BQ86_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077657.1">
        <property type="nucleotide sequence ID" value="XM_038221729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQ86"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221729.1">
        <property type="protein sequence ID" value="XP_038077657.1"/>
        <property type="gene ID" value="LOC119745405"/>
    </dbReference>
    <dbReference type="GeneID" id="119745405"/>
    <dbReference type="OMA" id="WIILIWV"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="79"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="397" mass="43805" checksum="2DA0F2493656275E" modified="2023-02-22" version="1">MGTSDATMVFSNDTETAVSVESYSATDFSINTTTISGVENNTIMGVSTAGPVSKSLQTYEERVVVAVCWLLIALINIIGNTLVILAVVFSKKLRTSTNVFVISLSVADLLTGLAIPMSAVGLLSPGNTWPLSTEAPCYLAGMLLFVSSSASLFNLASIALNRLILIKRPMTLYRSLYTRRNLAINVAVLWLVAIATMVIPPLFGVGGFGYDEAHHTCSDLDTHPRAKTFERIQTFLSYPIPFIIIVSSYIMIFLHVRRHFQTQRSMRSAISDTTNASSSNGSSSFVVSDNATVLKTAQHNRIYRQQLEITKNLFMAVCAFFVCITPYCVALFIPNTDRYLLFLGVVFTCNSCVNPIIYASKHPQFKKVMRRMLQCRYSQIEEPSDALKALMACRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BQY8</accession>
    <name>A0A914BQY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual oxidase maturation factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078574.1">
        <property type="nucleotide sequence ID" value="XM_038222646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BQY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222646.1">
        <property type="protein sequence ID" value="XP_038078574.1"/>
        <property type="gene ID" value="LOC119745939"/>
    </dbReference>
    <dbReference type="GeneID" id="119745939"/>
    <dbReference type="OMA" id="PLWILSN"/>
    <dbReference type="OrthoDB" id="10042652at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46135" checksum="1B27E4CED106FD92" modified="2023-02-22" version="1">MGIPYSALRVKGTPTQYASNKTAVTADVTEMGFVFAFLIIAFSFLIILPGIRGKQRWFTLIRFVVAMFIGAGILLSAWGQEWERAEILDTETAYKAFYKGEIHADIGVKIGLNSVNITLKAKDGSIEEHPDEKINYNERFNFWGGQGRRGFGRFSGRINREFREAQWSGKPLPVLWIAEYFALDGEDIRWGRTYRTAGFYTWIMVWTAFPLWILSMALSFMVLRYCGYFLMMTGGFLWLGNIMWAAVRFGSTNLIIPFSKEKVLTFSYGPTFYLCFVAGLVAVVSGFIVFIMDIRFPNVLTTFFNIDPLADYEETFVYDKSAAAGTSNGASNGGPADSETVVASKPMYRQRAQSRFAVSRRRPRSSLAEVAEEANDTHDNAPPGEKSQPSEKPASGPGENILLTEIKAEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSI6</accession>
    <name>A0A914BSI6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_038078576.1">
        <property type="nucleotide sequence ID" value="XM_038222648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BSI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222648.1">
        <property type="protein sequence ID" value="XP_038078576.1"/>
        <property type="gene ID" value="LOC119745940"/>
    </dbReference>
    <dbReference type="GeneID" id="119745940"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF8">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="430" mass="49618" checksum="AB77E91BC94A409B" modified="2023-02-22" version="1">MAIRRVFCRFQSLKIGVSATVAVYLVLTLVNFGFKRVVRSPRVVQNGESNLADYFEKFVAPHQQHLRKASGFPAKNESVFKELGDSKFSFSRTNNNRSNVLFGADVFADDSSIVNPPEMPPSLNLDEVPFMRDARFTRSKCPKTVSSLTKYSRWFRERFQPDIKIFLETSDVGVYSNYYKLLHFRQPFGFRMANKTKLTTIVNHPNFTDAPLNADGRPNRCLRCAVVGCGGILNGSGAGVEIDSHDYVFRLNRAISTGHYAEDVGNKTSFYTFFPESMHAQDVQDKNATFFYAMFKSYDLDYAINMLNDDTPPRYISRGKLFRLKKAKFDKRKLKIIHPDFFRYVFTRYLDTKANRPTTGAVVVFLALHLCDEVGIYGFGYDPRFTLHYYDKTFRSHTDKATALHDVDNERELWHKLHEEGVLRLFKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTK1</accession>
    <name>A0A914BTK1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078991.1">
        <property type="nucleotide sequence ID" value="XM_038223063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223063.1">
        <property type="protein sequence ID" value="XP_038078991.1"/>
        <property type="gene ID" value="LOC119746236"/>
    </dbReference>
    <dbReference type="GeneID" id="119746236"/>
    <dbReference type="CTD" id="51605"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="484" mass="54780" checksum="6EF454B9C039F780" modified="2023-02-22" version="1">MASTDVIKQGQNVILKKGKSLRLYQVWRKRRVHLDKKHFFLDEAIGKPYGTTWDVHGQNVCLVTPDEERDEDVREGGTDNRGINDDTRSQKLSDEDIKALKSKGQHGAAIVEQLVENSTSFKEKTVYSQAKYLKKKRDKHLMRFQILRPNTILLCEMYLMRAPSKNIHLRIDTLAQILTAANIQSGINVMMMETCQGLLLGAIMERMAGKGTVVQIHSESAPVRLAVEAYNFPSSYKDTLHAFPLDQLGFLEPKESVESNNPEQSTSEVSDRLQACKTEEPQATNGKSVESKDCPQCSESDAKERSVGHRTQKEEERSNGEEENDSNVEDCDAAADDAGMVAMEADCQSGEGGTQGQKRKFQVNPEKEARKQRRRESLCRVRDLLHNTKMDVLVMACRFQPLPIFTALFKFLAPSRPFVVYCHYIEPLMECNEWLRNCNNAVNIRVTETWLREYQVLPERTHPNVNMSGTGGYLLTGTTVSNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BTX6</accession>
    <name>A0A914BTX6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 8 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038079182.1">
        <property type="nucleotide sequence ID" value="XM_038223254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BTX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223254.1">
        <property type="protein sequence ID" value="XP_038079182.1"/>
        <property type="gene ID" value="LOC119746359"/>
    </dbReference>
    <dbReference type="GeneID" id="119746359"/>
    <dbReference type="OMA" id="YKQHSNI"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF47">
        <property type="entry name" value="LIPOPOLYSACCHARIDE 1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44317" checksum="9205AB406C39F8E9" modified="2023-02-22" version="1">MRRFNSVMARIYPTTVVALMIIAVVVYMLVFYLPLPSNQGDDRKPKDVLAAKPDGPLLLAPAHPKRNTSKGSKSGLRKAPQLHKLSHKGKDVVNVVVCSDEKTLGGLIATVNSIWLNTKSHVKFYIMVDKESLLHLRSWLAIPALRDIDYTMVAFNESWVKGRTQAKDVRRESVSPMTFARFYFTKTFPALTGRVIFIDSDTIVQGDIAELNNTKMEPGVALALSDDCSSSSSRASLRQNVYSNYLNFLNENIKKLGLNPMACSFNAGVFVANVTLWKEQKITERLDYWLSINAKEDIWSTQRGGGNAAPPMMIVLYKQHTDIPPEWHVRHLGVTSGTRYSENFVKSAKLLHWNGHFKPWGRTSQHTLVWEKYFLPDPMGKFRLVRKYKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXM4</accession>
    <name>A0A913YXM4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044288.1">
        <property type="nucleotide sequence ID" value="XM_038188360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YXM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188360.1">
        <property type="protein sequence ID" value="XP_038044288.1"/>
        <property type="gene ID" value="LOC119718926"/>
    </dbReference>
    <dbReference type="GeneID" id="119718926"/>
    <dbReference type="OMA" id="KHEFQQS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000189">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="242" mass="27578" checksum="81575CE629B1D220" modified="2023-02-22" version="1">MIGGAMSTDSEAEKRAVSPDDDSGHESVSDLSIRTKFTNFFIDNILRPDFGRCNYEEEEGETEEDAGKRDDSTERKQTQTTGRVRNVEVVSEKGSKQDHWPAWVYCTRYSDRPSSGPRTRKIKARTSIAESSPTRRDEKRPRTAFSAQQLQRLKHEFQQSNYLTEERRRGLAAELRLNESQIKIWFQNKRAKIKKANGLRNSLALQLMKQGLYNHSTVAVVSVEGEDTSNSTRENTTSLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0U7</accession>
    <name>A0A913Z0U7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044295.1">
        <property type="nucleotide sequence ID" value="XM_038188367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0U7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188367.1">
        <property type="protein sequence ID" value="XP_038044295.1"/>
        <property type="gene ID" value="LOC119718980"/>
    </dbReference>
    <dbReference type="GeneID" id="119718980"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037663818" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="9">
        <location>
            <begin position="676"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="819"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1229" mass="135034" checksum="990CD2E84F078D62" modified="2023-02-22" version="1">MKPVMKRPLFWLVIFLAFVLPENSISAMDLQLPSNNQPRCFGISRGKHFVLGFIDNSDGGRPESRELFILVVAFSNQQTTVTISSKHEIAGEPFQETFVIDAGGFIRTNVPVELVMENTERGHKVLDISASSDVSVYGLMYQDHTTDGFLSIPTNNLGMQYVVTTSRPIDDDNSQFAVIGTEDSTLVQVILRGAVTFEGQSYSPGDVLRFTVNELEAVQIQGRILVDLTGSIIQSDKPVAVFSGNECTNHAGSYCDTVTEQLVPVKSWGQKHIYTAARSDDDNIYRIVAYFGKTNLTIPGLEHQSLEPGEFWEGRLSGSGLVTSSKPALMMQHLASIDGITVDPSIIQVPAEEHFGFVFGFTTPPHSGEDSSGYFNFINIIVKRESRQTVYLNHFPINGTNALVSDVPHTSYISLTVQLPKGEGVYYVEQIDPYSSPLSVIVYGYERAESYGYAAGLSLSSNKKVLRLTPYYLRELGGELFTMTVPCLKTNAISFQIAAKCKFSTGFGDVIVSGERTDSYTVVCITPTFYKNGLTSVYISLDDGESFPYSGIVYVASEDDLPPLVQIQQVNSAYGDGIINLTFDNPIMFSWDPRSLGEEVSHVTVMMQNTDYDNDGNPVLMEGVAVRSNVLNNGSLMIYPSELDSLIGDGLSLQATYLTPSAVCKRALPLVIVWAIRIYKVLKIVKKICNIPKYHFKTTVPTGLPASPCNTGQADRDQNFQEANFANSFFHPGAEKCYRSVNSLPTGAGQQSCYGTDGNILVGSPGGGTADRYSPGDNFWKHQWFDVLPWLCLCKLSSNCEEYYMYRPSDDCSDYDPPRPAGGTGDPHLTSLDGYKFTFNGAGEFLMASSAVHNLTFQARMERYRNTNASVYTAFVLQTNDSSKVQVQMSNMNETLILVDGEPLRLDSLPVKVHHLRGVRIRFNSDMTKINIAVSAGIAVTVYIDTAVMSFIAQLDTKFQGQVQGLLGNLNGNPDDDLQFPNGTILEPGSSLKELHDFGLEWLVAPEESIFTYISPFDYSTYHFPEFSPTFEIPDLNEVSQEIKDLCGDSTECVFDAVITGSLSFAKETLVVTVTITEVKKGLVKIVSCGYPGDVENGSLSGSVYLVNATVDVACDDGFTLKGSSRLTCLEDGQWSSDLPVCDDVNCGFPGDMEKGLAPGIIAGIVVGAVIAVLAICGLIYFFRKRNMKRNNLIYPPPILATLFEQSRIHLFDFQNSSDSHVVQQIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z214</accession>
    <name>A0A913Z214_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045046.1">
        <property type="nucleotide sequence ID" value="XM_038189118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z214"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189118.1">
        <property type="protein sequence ID" value="XP_038045046.1"/>
        <property type="gene ID" value="LOC119719619"/>
    </dbReference>
    <dbReference type="GeneID" id="119719619"/>
    <dbReference type="OMA" id="GPHIFMC"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041540">
        <property type="entry name" value="VATC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18716">
        <property type="entry name" value="VATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VLRF1" evidence="16">
        <location>
            <begin position="231"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="710"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="849" mass="96178" checksum="16D1613CACB246F0" modified="2023-02-22" version="1">MAEADVESQKAAMSTNPDETNLSSQDETKKKVATFHLYDPDISTSLLKGIMLSSCQLNTEIDEVVEESNDGPVKRPETEVYAIATKKTCLLCSCNFTSRQQQIDHYKLDWHRFNLKQRMIGAPAVTEEQFENISGDVSSISGSDSSTDDDSDNDSDRSPYFNSGSRTPDSPNLSAKRREPDHHVKGRRHPKVFFRNSDGQLLSVQRCVLHGKRDMPTTQQELVAMATQLPIRMRWLVLMIGGGHFAGAIFDGKEVPAHKTFHRYTVRAKRGTAQGMRDSQQGGNQPKSAGASLRRYNEAALVEDIHALLACWDDQIRDCHRIFLRAPSYNKNAFFGGKNPPLDRRDERIVTIPFATRRPTFKEIQRVHGLLSTVDCYGNAVEAERRIMEAHSPKISQPKKTTKMKQDENTQKTTEEVENSKGKRSESEGEVDLVMVEEEISTLDLQEFETNVGKHKRPKKKRKPRKKQENKDDQDKSNNKMDALCEACRKGDWDQLKAMLTRPANEEGTNNAAPTMEGKTDVEETSQILETKDCDLPRTEQNIQHKGIENSITENETALKHAAEEHGNKVHAFGKEDSNTEDLALESDDKSLANEIQQGKHCQNSEVKDCPLLPGNEEGMLGNQQGMMGNGGDLADVVNRPVDELGNTLLHVAVQAERATILWNLMECGADPAIKNRKGQVPYVLCNNKELRKEFRRFMAAHPGKYNYEQAQIPSPLTSDKEEMRAAKAAEKKRIQKKNKRIREQEQKEEQKRQEEERRKREAEEEEKRKFASLSDREKRALAAERRFQAQLAVQGATATETTQLSNTKRCWLCGTSLVGKVPFEYLDYKFCTIQCVKQHKQQQKTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2E7</accession>
    <name>A0A913Z2E7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046003.1">
        <property type="nucleotide sequence ID" value="XM_038190075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2E7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190075.1">
        <property type="protein sequence ID" value="XP_038046003.1"/>
        <property type="gene ID" value="LOC119720410"/>
    </dbReference>
    <dbReference type="GeneID" id="119720410"/>
    <dbReference type="OMA" id="QSESIMV"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="58983" checksum="D91B88AB7B4409F9" modified="2023-02-22" version="1">MAINWGGVAGIIVFYLLILAVGLWASRKNKGSSDQEQVVLAGRNIGAVVGIFTMTATWVGGGYINGTAENVFLPEGNSGLVWTQAVWGYSTSLVLGGLFFAKIMRSKGYITMLDPFQLKYGSRMGGLLFIPALTGELFWTAAILNALGSTISVVLELDRTLSVIVSACIAMFYTFFGGLYSVVYTDIIQLICIFVGLWICVPFAMTNEAVEPIGSTSEEWLGTIESDQVGLWLDSALLLVCGGIPWQVYFQRVLSSKTPRTAQILSFVAGIGCIIMGIPSVLIGAIGASTSWDNTTLDLEKIDPYSQTSLILPLVIQYLTPPVISFIGLGAVSAAVMSSADSSILSSSSMFTHNVYKQVFRPKAGKLELLWVMRACIVVAGVIATALSLSINSVYQLFVFCSDFVYVVLFPQLLCVIYFSKCNTYGSLLAYIVALILRFGGGDSLLGIPALIKYPYYDEEEEVQLFPYKTLSMLSSLLTILVVSYPLDYLFKKGTIPKRYDFFRCVVNLPSAKDQVDSGDDEANVEMEKRDPKVSSPAGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2G8</accession>
    <name>A0A913Z2G8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rheb</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045897.1">
        <property type="nucleotide sequence ID" value="XM_038189969.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045906.1">
        <property type="nucleotide sequence ID" value="XM_038189978.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046021.1">
        <property type="nucleotide sequence ID" value="XM_038190093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2G8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189969.1">
        <property type="protein sequence ID" value="XP_038045897.1"/>
        <property type="gene ID" value="LOC119720328"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189978.1">
        <property type="protein sequence ID" value="XP_038045906.1"/>
        <property type="gene ID" value="LOC119720336"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190093.1">
        <property type="protein sequence ID" value="XP_038046021.1"/>
        <property type="gene ID" value="LOC119720429"/>
    </dbReference>
    <dbReference type="GeneID" id="119720328"/>
    <dbReference type="GeneID" id="119720336"/>
    <dbReference type="GeneID" id="119720429"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20833" checksum="62353BEAB9A24038" modified="2023-02-22" version="1">MPPPQKDRCIAVMGFRSVGKSSLTIQFVENQFVDAYDPTIENTFEKMIKLGTQEYKLKIVDTAGQDEYSIFPQSLTFTIHGYVLVYTVTSQKSFDVVKIIYEKLLDTTGNVNVPVVLVGNKKDLHMERVISTAEGRELANSWNANFIESSAKQNESVVDIFKTLLQIIEKKDGGTQKKDNDCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3N7</accession>
    <name>A0A913Z3N7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045631.1">
        <property type="nucleotide sequence ID" value="XM_038189703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3N7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189703.1">
        <property type="protein sequence ID" value="XP_038045631.1"/>
        <property type="gene ID" value="LOC119720146"/>
    </dbReference>
    <dbReference type="GeneID" id="119720146"/>
    <dbReference type="CTD" id="10715"/>
    <dbReference type="OMA" id="IATWHFQ"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="89"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="377" mass="44083" checksum="07B4A9E9A9CD6D21" modified="2023-02-22" version="1">MGITDLFFYPDYYGLVKTFLTEMPEYYRTEPIHPDGFLGEVRTYCEAKWSDLFLVVILAITWTMLRYLLTMCVFKPTATAYNLTKGNINKMAESAWRMFFYITSWSYVAYVVFQSEFDIFGDPPSVFKGWAPGMVVPPLIYWAYAIQCSFYLHCFFATIFLDVWRSDSIMLIVHHVLTLSLISFSYASRYHNVGMLVLFCHDFCDICLEFSKINIYFKIRGDGSFHRIHDFGANVGFVFFSSSWLLLRMYWFPLKVLYSILPSTAKVYYEGHLPFGLEFNVMLWLLFGMDVYWFSFIILFLVRILTGSMKELEDIREETDEEVVKLKKEKELKEQQKKEGGENTDQACNGVVEGNIKNGDSVKQRRKNPDENGKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4N3</accession>
    <name>A0A913Z4N3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038046793.1">
        <property type="nucleotide sequence ID" value="XM_038190865.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190865.1">
        <property type="protein sequence ID" value="XP_038046793.1"/>
        <property type="gene ID" value="LOC119721000"/>
    </dbReference>
    <dbReference type="GeneID" id="119721000"/>
    <dbReference type="OMA" id="IAYPIWI"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="498"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154743" checksum="4AAC8494E6224619" modified="2023-02-22" version="1">MATKFPEMQWDASDLAEEFKIFRQRIELCLADQDITDQAKQAVKIKIAVGKEGLRKINASSLTEDEQRDPSKLWDLFEKQLKVKLNFRIHRLELMRYRQKPKEHLDEFVNRCRAKAVECQFTVEELTERVVELVIASTPSESFQKDLLDRPIGYSIDEMLIEGRKYEAIVAGKQSLQSMETGGASVNAIWSKSRACRNCGLSHPPRRCPAYHDTCKACGAKGHWSKCCRKTRARSRQRRGSKSPRRRRSPSGERRRSPSRDRRPQQRKPKGRKKDESSTPNTTEQETDVHQLEYTDNAYEEVFHVVTVPDFHKKNDNTGNEAYRMLDVVCPDLEGKHRLKVKIDTGAGGNTLPLRTIRQMYGDTWRSQVKPVTTKLTAYNGTPIPCLGSIDLLCRYQDPTWSENRFYVVDVTGPVIAGLPMCRDMGVVTIHAARLTSVQSIEQLMEAYPDQFDTIGSFKRRATLYLKEDAVPHIDPPRKYSVHLKPKLKVEIDKMEALGVIRRVAHHTDWCSSITTSLKQDGSIRVCLDPKRLNQSLRRCPHKIPTLEELNPEFSQARVFSKLDAKAGYWAVHLDEKSQELTTFRTPFGRYCFQRLPFGLAISQDIFQQCMDEIVDQVPGCVCIADDIVVYGRTDEEHDANLRNLFEVAGREGLVFNSTKCRIKTKKISFFGSIYSDVGVQPDPGRVEDIHNLPTPQDKEDLQKFLGLITYVSAYIPNLADKAAILRDLLKKNIPFVWQEDHQAAFEALKLSITADACLQYYNPEMPTVLEVDASQKGLGACLTQHGKPIAFASKSLSPAQKNYSNIERETLALVFGIARFHNYLFGKEFVVYSDHKPLEMIWRKPLSSAPPRLQRLLIKVQGYNFTVHYKPGPTMILSDALSRLPNPKKNEDIHLDRLVGGIDVIEGPELKHIDLLHFGQTKQTQLQVQTARDPTLSSLTQVIYAGWPDEIKELPRDLRPYWPYRDELGISWGVIFKGKQIVIPDDLRQDILAQLHTGHMGIEKTRRLARETVYWPNISRDIDIAVRACEYCQENQPKQKKEPLHPHEIPSTPWTKIGTDLFEIGGDDFLLIIDYTSKFPVVHRLRDTKSATVAGVTSRTLGMFGAPAEIISDNGPQFVGAPYQDMCASWGISHITSSPRYPQSNGFVERAVRTVKTLIKRCQKSKQNVDKALLNLRATPIDSKLPSPAEILFGRPPCTSLPSRRPYTEARHEEMKDAHDKRRDRMKADYDRRYSANELPPLHVGQKVRILDQDSRAWLPGEVTTVCREPRSYKVATPNGSILRRTRSHLREMTDSRHSITPKRVRFADTEKTKDLSKQHKLPNHSNNAARATGDTPQTTRSGRVIRRPVRYIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z519</accession>
    <name>A0A913Z519_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Helicase SKI2W</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045840.1">
        <property type="nucleotide sequence ID" value="XM_038189912.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189912.1">
        <property type="protein sequence ID" value="XP_038045840.1"/>
        <property type="gene ID" value="LOC119720272"/>
    </dbReference>
    <dbReference type="GeneID" id="119720272"/>
    <dbReference type="CTD" id="421171"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="354"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="620"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1285" mass="144197" checksum="7C08F4004107C7E8" modified="2023-02-22" version="1">MADDEWAELEKCRLDLTDKDSPDGLDFSLLELGSTGQVTAVPRSDPSTGPAPLSTLPNGLPPVLQDLKVKTLQFLDRPEKLPIHDVKAAQRFWPRKADPCSLYKVPSCPVQTTLQVERHPTTGELTGFREVQMEGTASTAKNSLSLRRQPGPPTQSVRGSSTNFPFWPGGIDEPSAETIHARGEDDEDIDFENDLLSMPPGLTNGMAFESKPTIVKTDTPDRSTPNETAPSKPASHILKLTDLMIIDDGDEYAFSDKEDDDSDEYDDGDASEVGGDSRKEADEVNKEAAESLDKMLPKEMMVTRQPKKEGAELTKEQWAVNVDISHPVSDFHRLVPAPAKEWPFQLDVFQKQAVIHLENHDCVFVAAHTSAGKTVVAEYAIALSLKHLTKTVYTSPIKALSNQKFRDFKETFGGDVGLLTGDVQIKTDSSCLIMTTEILRSMLYNGSDIIRDLEWVIFDEVHYINDSERGVVWEEVLIMLPAHVKIILLSATVPNTLEFADWVGRIKRKKIYVISTLKRPVPLEHFLYTGNSTKTNNELFLIVDSTKKFLTSGYHKAVDAKKERESKASSSHGAKGPRQWPHKGDKGVYLSIIEMLRKREQLPVVAFTFSKKRCDENATMLTTLDLTTTNEKSEIHVFMQKCVERLKGTDRMLPQVLHMRDLLKRGIAVHHSGILPILKEMIEMLFQRGLVKLLFATETFAMGVNMPARTVIFDSIRKFDGTGQRTLLAGEYVQMAGRAGRRGLDTTGMVIILCKGDVPESAELHKMMLGKPTQLESQFRLTYTMILNLLCVEELRVEDMMKRSFSESSTRKDAKEYEAKLRVIQEEMSNVQTLNCYLCHEDLDQYYQTCKQLQGLRLELRKMIASHPLGVKALSPGRVVIVSTKEHRNALGVVLSSSTASKERTFKTLVLTNHADPGGAGMQNGTADPGGGHRVHVQPLRKEPLFRPEGPCGHTVLDLVGQEIGTVTTVAIKIASDRIAEDFKKRQIPRFRDNPPSQSTSLATQELLRITEANPEGLTSLDPVKDLHLRELDQVEKFQERDTLESLLDQFGCLNCPNFLEHFGVMCHRMKLKEDFNHLRFLLSDQSLHLLPEYHQRIQVLRHLRHIDGANTIQLKGRVARVISNHELIITELVFQGLLTGLPPEEIAALLSCMVFQEKRCSEPELTPSLKEGVGKIKAEAKRLAEIQHECGINLSVQDYVEQFRFGLTQVVYEWARGMPFADITNLTDVSEGIIVRTIQRLDEVCRDVRSAARIVGDPSLFQKMDEASQLIKRDIVFAASLYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z5H2</accession>
    <name>A0A913Z5H2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046256.1">
        <property type="nucleotide sequence ID" value="XM_038190328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z5H2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190328.1">
        <property type="protein sequence ID" value="XP_038046256.1"/>
        <property type="gene ID" value="LOC119720593"/>
    </dbReference>
    <dbReference type="GeneID" id="119720593"/>
    <dbReference type="OMA" id="IRTFKFM"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="22127" checksum="3F7E110F23CBED9E" modified="2023-02-22" version="1">MKKRRRKKSGQCHCQCLDSAAVNSPPMSPPCWSPASITYFSLAENLSGIPDVPTGSGQEFVLEDINEEIDTDGVFASFLKADDTETGVGGRGDKKFLRFVHPLTDNRKLVWETALWNNRLYIQVPTDLAKQGSRDSLVALLDAAEEHLGCTQVIICLPRDIVDRAQLIRTFKFMGFELVPPGHPELPGSPDFLFMAYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6R4</accession>
    <name>A0A913Z6R4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046696.1">
        <property type="nucleotide sequence ID" value="XM_038190768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6R4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190768.1">
        <property type="protein sequence ID" value="XP_038046696.1"/>
        <property type="gene ID" value="LOC119720901"/>
    </dbReference>
    <dbReference type="GeneID" id="119720901"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF574">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18320" checksum="6EF1BE73FFF45F3C" modified="2023-02-22" version="1">MYKLAQLAIGCSVPERPWNGKEVRFDRRKRQLRGRAFFKCKSGFQPVGPRTKTCSKTQRGLEWTGGIIECRAENSCQSPGVLHGANWTLVESDRRSRHDDASFSPNTKIDVACWPGFVSIVGLSQITCGMSGEWSSPMPTCREVICTSLLESEAEISHLQKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6T2</accession>
    <name>A0A913Z6T2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046716.1">
        <property type="nucleotide sequence ID" value="XM_038190788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6T2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190788.1">
        <property type="protein sequence ID" value="XP_038046716.1"/>
        <property type="gene ID" value="LOC119720923"/>
    </dbReference>
    <dbReference type="GeneID" id="119720923"/>
    <dbReference type="OMA" id="ENCACND"/>
    <dbReference type="OrthoDB" id="9631784at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="405" mass="44103" checksum="F00D776A21288B54" modified="2023-02-22" version="1">MFFLLNISGTLTKLNKVASDGLPALQEAHVDEYRVCCALSKLHHFSIEQNCSTTKPQPDLKLCDSLMPNDILRVVLWVLGISALIGNPTVLIWRLKQKGDGGGKKTLSRMVGNLAIADFMMGVYMIIIAGADLAFGEDYFFSAPEWRSSMLCKVAGVLSVLSSEASVFFVTLISFDCFLGIVFPLRNFSLGGKSTTTIIAVLWFLALCLSIVPTLSVGSDSDIYGLSDVCIGLPLTTKASDVRSETLSSFISLSLPAVDINTFVATGEKPSWILSIVLFLGVNLVSFLIVLSCNVAIFISVKRTTRAVRANAHREREIKMAAKMALIVMTDFCCWMPIIILGILSQTGTVALSTEVYAWVAVLVLPINSSLNPFLYTFFTVCFAAKPKAKTPKVNQRIQLSVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z6U5</accession>
    <name>A0A913Z6U5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038046726.1">
        <property type="nucleotide sequence ID" value="XM_038190798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z6U5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190798.1">
        <property type="protein sequence ID" value="XP_038046726.1"/>
        <property type="gene ID" value="LOC119720931"/>
    </dbReference>
    <dbReference type="GeneID" id="119720931"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF17">
        <property type="entry name" value="SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="40"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="35596" checksum="E92C887A612BB063" modified="2023-02-22" version="1">METTESRNNEIVTTETVTHRDDYAACGYSEYAERRIFGRISGGTDAAEGQWPWQVALFCHRNCRRCEPRFFCGGSLIARNWVLSAAHCFEKCPWSAIRVYTGIRNKSRSALRLLDPALVYSLDGDDALIKHEAFNSDLDNDIAVLRLSRDVMLSSGIRPICMPKLAMKERALYSPHGEPPYVAGWGTTQPYDYGNLCFDRYRPTSSLLQYLVIPVRSNSECRDSFINHYECTSVSAYKPAIAFCAGVPEGGVDACTGDSGGPVMRQMTVADGSKRWVQIGIVSWGEGCAVEGRYGIYTRLSAYTDWIESHTSTRDPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z796</accession>
    <name>A0A913Z796_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038047597.1">
        <property type="nucleotide sequence ID" value="XM_038191669.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038191669.1">
        <property type="protein sequence ID" value="XP_038047597.1"/>
        <property type="gene ID" value="LOC119721590"/>
    </dbReference>
    <dbReference type="GeneID" id="119721590"/>
    <dbReference type="OrthoDB" id="5974690at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="627"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1360"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1360"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1381" mass="148435" checksum="34D7F8BC05D72A76" modified="2023-02-22" version="1">MYNYARAYAAAFSESYKKACDLLDHSAGGSGACYGNYGPRSATVRGRCPHSARVGSGNPPRGDTRGRSRNAGQPITGSRRVSPSGYVHRQIDSAKDERNLKPPLQGPQVKRLFPLRRQLQRNKVRPLNTDGPSLTPEARPPRPSARVDSARYAMFTASSQISNTNRGSGNLVVVGQSCKLTNINSDRTSSCPPVDDDDRPSSVVSGQARVPPRSRPKRPWTSRLRSLFAPRNRERMTTVQPFVTPQGQSEGQVSRPRSPKEDHSDPGQVSRPWSLKEDHSDPGKVSRPRSLKEDHSDPGHQSRYTSALMKNREAKGFGGNASTGTMYRRQGSAALATRPASCADQPLPIPGVPQLDWDHLQSSSLSALMSDNPILSQEQEEVTSLIVNYDDGSLLTLTPRDASLCNSSVSILPSFPSQRQEPAMEDGKPASDEEVEIPNPDPLTSISRGDDKSSEIKLTPQPSPMQDREGEDMTPDDNSVSKPVLQSLSTEGTCGSSDFTPCLCLEVQEQVQEDQDVAHNNAESTLKSVAPCSTATSEESPTNILICHLDRLQAEVVEDGDRASDLEGANSRHEPTSPSRNDAPSSPTTSTSSVMSSDENRTPDDGKPCTLNEVLISALPSLTSAIYEKEALERHGDERSDDEESPKQQTSASSSTRSSLSNPVKSFSMSPLSESTESTIKQDEDMVSENEGLILEPLLSSENDITPSIPMATSSLATSQHHNEVGEGGDDIDGLESISKPMSPSELSVSTASTSSSSSQSLGPGTEDEDFIYDDGREGSSLSSMRAAGTASEEFQTRKAKDIIRELNQMTSSTEDVESRNECVKSASPANPAKKPSDIEEARGTSSTSSQALEDALSPRQVASSKDSELSSSIIARKDSNECLEDLEGNAQKSDATSSTTAQARMDILSRQETASARDFESPSSVIARTDSTNLLNDLKGKAQGSESTPNTAAQVQTDSANLQGAASARDLVSSSSMVAKEGSNKNLVEIAGIEQKSDSDRQEPTPAGNHASSVSNLSEKNSTSTSPRAIVPSLEENQHSLQPNISKKSPSKDASADDKKSSIANASSAQTSQATEGPQDGIPELTPAAYPSIDPSELEFILSDKGGRVMLGCGNYGEVLLMRRQGDTTLLAVKVLTRSFSLLQQEVAAMHAVMNCPYFPKFVGVIDYCSYAQELVGGVGRNTAYNFSKARYDYNLLNALEWLHVCRDVTEGLKALHAAGWLHNDLHCGNAMVCPNPPGSEVAWCGKIIDLGNAQRTSNPGPLVILEYEEQNMFYKVAKQCAPEVLEGRGTFTEKSDIYSLGKLFVDVAGDANILHGLRLLGEFSCMRRSPGARPTLEAISLKLDHLIAQLLEAHQQSSSATPALPSSSSPSSNLRRHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7A6</accession>
    <name>A0A913Z7A6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rho-GDI gamma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047607.1">
        <property type="nucleotide sequence ID" value="XM_038191679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7A6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191679.1">
        <property type="protein sequence ID" value="XP_038047607.1"/>
        <property type="gene ID" value="LOC119721598"/>
    </dbReference>
    <dbReference type="GeneID" id="119721598"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="202" mass="22985" checksum="4CE95FE7C5619BA5" modified="2023-02-22" version="1">MSGKVKRGDEPEAVPAQRGTEEPTRDYPPPKQMDLQTLQELDADDESLVKYKQALLGSTADFLDEGGQNVLLKAMVFAPVDHEETVLNLTGDISQLKHKPIVVKEGTEYRIKLKFRVQRQIVSGLRFFYVVSRKGIRVDNANSMVGSYGPKTEEQIFQTPVDELPAGMISRGVYIVKGKFLDDDKNIYLEWEWSYSVKKDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8U4</accession>
    <name>A0A913Z8U4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048213.1">
        <property type="nucleotide sequence ID" value="XM_038192285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8U4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192285.1">
        <property type="protein sequence ID" value="XP_038048213.1"/>
        <property type="gene ID" value="LOC119722240"/>
    </dbReference>
    <dbReference type="GeneID" id="119722240"/>
    <dbReference type="OMA" id="NIMINQH"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="289" mass="32654" checksum="88012E0417DB8CA7" modified="2023-02-22" version="1">MASQILPSSHGELWSLKTKLEASGAMIIEAGEFNWDSSRYLGQGTNGTVYCMTWNRKDHGDVIQVAAKKTTKVDSNEIEVLMKLKHPNIIGYYGVVFKEPSVFIVMEYAPHGSLDTFLDDRHQAGNMLPLNQVLQWCTNLALAVKYLHDKDLVHRDIKASNCLICQDGELKLCDFNDARQLATTVSTEQRGSLPWMAPEVMSEKKFSKKSDIYSLAVVFWQILTCQVPYADRQTGVQIMWCVCTKNERPSIPQGCPDEFAALMSDGWKEKWSERPDISQILKRLSSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9P7</accession>
    <name>A0A913Z9P7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mesoderm induction early response protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048508.1">
        <property type="nucleotide sequence ID" value="XM_038192580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9P7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192580.1">
        <property type="protein sequence ID" value="XP_038048508.1"/>
        <property type="gene ID" value="LOC119722452"/>
    </dbReference>
    <dbReference type="GeneID" id="119722452"/>
    <dbReference type="OMA" id="PRRCKYL"/>
    <dbReference type="OrthoDB" id="5916873at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000025">
        <property type="entry name" value="Mesoderm induction early response 1, transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="188"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62930" checksum="BCC5DD8758198A68" modified="2023-02-22" version="1">MAEPATSDSSPETDQDFDVTAEMLVHDIDDEQTIDEEEGNEIGECFSNELDDLAEEAAIPVDQLWRMYANPPPPMASASTPPIHQQEDSTETDGSTDEILNSRNLTLDKEEIAQDLLPNQGENVEEGTGEESIDDLHSDLFPGPGSHASDSPGSYGTHRLLRSNTATDGDSDSGSEDSDYVPPEDWKKTISVGSDFQAVIPEGLSHYGDAPAYDNEDRLLWDPNQLCVEPVESYLREVQRPPPGTMSVKSLPLGSHVRDDERSLYILLQCGHNVDEALRRHRMQIAPPMDEMSLWSEEECRNFESGLRAYGKNFHLIQQNKVRTRSVGELVQFYYLWKKTARHDSFANQARLTKKKYHLHPGITDYMDRFLDDAESLVSPIPSHSLLDKHRINNKLSHSASMLSTLNGASPAELLSNGSPEVGGLVMGDLPNEMSATATATASQSLKHPADFPDSNGPAKHRKLEPELDHHHQQVMRNLGIVIEPDRQERDSVFMRDHLVQVVTTHADPRPPPSAPHPPSQVPPLSPAVKPIRGNITLVPPEHSVASDSVINVRPLVTSNMQATNPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9Y8</accession>
    <name>A0A913Z9Y8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048444.1">
        <property type="nucleotide sequence ID" value="XM_038192516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9Y8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192516.1">
        <property type="protein sequence ID" value="XP_038048444.1"/>
        <property type="gene ID" value="LOC119722410"/>
    </dbReference>
    <dbReference type="GeneID" id="119722410"/>
    <dbReference type="CTD" id="83959"/>
    <dbReference type="OMA" id="AIFHWIV"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000019">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="222"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="751" mass="85166" checksum="958B9A83E337103B" modified="2023-02-22" version="1">MFAQHERIPMKDFSNEVRATLDVDNFVLQASLLLDITENSVESIVDLLVEKLLEGDEREEVITKEVKSALFSHDSVHVLAKTIQGTSESLGGGFDYDQSWICAMCSVQSLQRRHVAIARLKHAANLGRTSQETRFFCLVMAPMREKGTKNALETARTFATILADIDCRQLLQNSKTEDEFKRILNCYAKELAIQQSHSSRHRLSRPSVVVPFDGFDVGSGFARGLRGDLKRRIPHYLSDFRDGIVGHKTIHKLISTTLFLYFACLLPSIAFGVLNDKNTHGKIDVRKVIVSQTIGGLFFCLFGGQPLIVMLTTAPLAIYIKIIYSICEDFKLDFLTMYALVGLWNTLFLCLYSVFDVSRIMKWSTRSTEEIFALFISIAFCVDAFKDLAYNFKRNYISEGCDQIQRMDLGLLDYLPQNDSSNVTQTVSIQPCLRENSLVYLILMFGTLWVGVTLHSFTKSPFLDASKREVLADYALPVSVITMSFVGSYLFSDIQLEKFPYQDGSFFQLVSLEQVNVYMIVGSMGMGFCLSLLFFMDQNITGAMVNSPGNKLKKGTAYHLDLMVVAGLNCVLSMFGLPWLHGALPHSPLHVKALADKEERVDQGHVHHIIVRVRETRLTILLSHIMIGLSVFMLPVPLQYIPNAVLYGLFLYMACTALDDNQLFERTMLLITEQAAYPPNHYVRRVPQRKMHIFTFTQLLQLACLCGFGFAPWPYLKMVFPLLIMFFLPIRHRLVPKVIHTKYLDALDRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBS4</accession>
    <name>A0A913ZBS4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038048335.1">
        <property type="nucleotide sequence ID" value="XM_038192407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBS4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192407.1">
        <property type="protein sequence ID" value="XP_038048335.1"/>
        <property type="gene ID" value="LOC119722345"/>
    </dbReference>
    <dbReference type="GeneID" id="119722345"/>
    <dbReference type="OMA" id="SHEIGCY"/>
    <dbReference type="OrthoDB" id="10059150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000008">
        <property type="entry name" value="ATP-citrate synthase alpha chain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="14">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="13">
        <location>
            <begin position="254"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="12">
        <location>
            <begin position="473"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="11">
        <location>
            <begin position="647"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="819" mass="89629" checksum="11292001CAC50F16" modified="2023-02-22" version="1">MQSGTQSRSAVCSEKVISEVSGKRLLRRRVQKRADGAKCVTVGGRTDWDELCKQNTWLRTQSGLVVKPDQSIKRRKHLGLIQLNVDFDTAKLWIQEKLGSKVKVDGVEGTLKQFLIEPYLPHQENEESYLCIYCHTESHDAVLFHSKGGVDVGNVDEEADHLYVGLEEMPQQQTIQETLLKNVQNTKTQMLCSFIQSLIKCFRDLHFTYLELNPLVVTDSEIHILDVAAKVDSKAAPLCKELWDGIQFAPSLCRDLHPEELRIAQLAAGTPCSMNLTILNKAGRIWSLIAGGGTSLVMSDTAAELGVRDEVACYTQFSGRPSADQMYEFTKTLIDLMVEVPHPEGKTFILSSNVADMIMMIKLKVGPMQGLMRALQECKEKLKTHKISLLMRRATLATVSKGQIPSALTELGLPVHIFSIAVPMTHLIQCALGLRDVETGVDDTDKICQPMNQQAESHEVIAKNNLDEIFNGDTKVIVVGLMTQAVQAMLDFDFVCGRKTPSVDAIVNPGGEDKEESFLWAEGQVSIPVYSSLETAMSNHTDATVVVNSAPGRDAYHCAMLAVKCRHIRCILMIAGHIPDRQTRTLVQMAHNNGVLIVGPCTPVHLMQVNFIKPGSFRCNKFGTIGGSLDDLVSLRLYRPGSVGVVTRSGGLSMELIIYIARNTDGLYQGVSLGGGKCTGSSFMDHLMSMQANPDVKILLLLGEFGGSEEYDICEALRSGKLSKPMVAFCIGECADMFKSEPGYFGHSGAGNDVALETAAAKNQALAEAGAIVPKTFDEIGDKLREVYASLIAKGQLVPKPEPPVPSIPANMKPRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF39</accession>
    <name>A0A913ZF39_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050402.1">
        <property type="nucleotide sequence ID" value="XM_038194474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF39"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194474.1">
        <property type="protein sequence ID" value="XP_038050402.1"/>
        <property type="gene ID" value="LOC119723684"/>
    </dbReference>
    <dbReference type="GeneID" id="119723684"/>
    <dbReference type="CTD" id="64422"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000001">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="307" mass="34877" checksum="E38C3F1FB54DB6B4" modified="2023-02-22" version="1">MQSLVNSVKGTALNVAEFLTPVLKESKFRETGVITPEEFLCAGDHMVHHCPTWQWTAGDPSKSKPYLPKDKQYLVTKNVPCHKRCKQMEYQEENEAIIDEEDGDGGWVDTHHYADQSAAQTETTEMTGAKEKEPTKTTDADDDEDDDEEAEDMEAYEESGMLEAEDSAVLDTTKLQKEEGASGGDSGILQTRTYDLNITYDKYYQTPRLWLYGYDENRKPLTVEQMYEDISQDHVKKTVTVESHPNLPQTMCSVHPCRHADVMKKIIHTVADGGGELGVHLYLLIFLKFVQAVIPTIEYDYTRQFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZH23</accession>
    <name>A0A913ZH23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051086.1">
        <property type="nucleotide sequence ID" value="XM_038195158.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051087.1">
        <property type="nucleotide sequence ID" value="XM_038195159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZH23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195158.1">
        <property type="protein sequence ID" value="XP_038051086.1"/>
        <property type="gene ID" value="LOC119724211"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195159.1">
        <property type="protein sequence ID" value="XP_038051087.1"/>
        <property type="gene ID" value="LOC119724211"/>
    </dbReference>
    <dbReference type="GeneID" id="119724211"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="247" mass="28750" checksum="4564A0C0DCB7055A" modified="2023-02-22" version="1">MDDIVHLNVGGVRYTTMRSTLTRYPKSMLFSMFSGPWKPAAQDADGTYVIDRDGPLFRIVLNFLRQGKLCLGDGFKEWSQMKCEANFYQIQELMDAVVASETLQTETAKKEREEEDELYDKRYDKPAPETEFVVITAKVNNYTKIGKMKYSGSREVLEKMPQLMSFLVPFVSPEDMDEHEAEMFGELERCGEIEAERNYELNRERPVHPMDIFQEVTAQGFEVCGYWPCPINPDCERWIFSRPVKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIW1</accession>
    <name>A0A913ZIW1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serotonin N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aralkylamine N-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55469"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77827"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038051732.1">
        <property type="nucleotide sequence ID" value="XM_038195804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195804.1">
        <property type="protein sequence ID" value="XP_038051732.1"/>
        <property type="gene ID" value="LOC119724655"/>
    </dbReference>
    <dbReference type="GeneID" id="119724655"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="235" mass="26535" checksum="8C5E103299129D40" modified="2023-02-22" version="1">MFARSQGLVCRPNARLFTCMYRPTITNIAGQRLRCKRALIYRLGDTKRLVSSESRHARTSPDGSSCIRQIKAEEVHEVWQLDAQSYPDYPTQPIEILTRAQRAAPDLFWGHFANGRMTGFACATLSSGSKWTHDSLFNHEPEGAVACLQSLCVYPEFRKMGIAKALVKHLVKHIEDNHNGVTNMCFVCEAHLIPAYRRMGFTYVGPADPSCLSGEESSQWYDMEYRVPASPKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKG7</accession>
    <name>A0A913ZKG7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051585.1">
        <property type="nucleotide sequence ID" value="XM_038195657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195657.1">
        <property type="protein sequence ID" value="XP_038051585.1"/>
        <property type="gene ID" value="LOC119724553"/>
    </dbReference>
    <dbReference type="GeneID" id="119724553"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037862346" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="137" mass="14794" checksum="44A2B6953C296104" modified="2023-02-22" version="1">MKPAVVCFLLIVLVKEGFAASSLACYSCSNCALSPEDLQGVVRLDTEQCDDALFLDFTGLSEPRCVKEVERDGTVNRYCSRKGMCKGIYLDECSSPDEISCRICCSSNMCNSALTLQVTSMSFLLAVFLAASLTSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZLV6</accession>
    <name>A0A913ZLV6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052314.1">
        <property type="nucleotide sequence ID" value="XM_038196386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZLV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196386.1">
        <property type="protein sequence ID" value="XP_038052314.1"/>
        <property type="gene ID" value="LOC119725021"/>
    </dbReference>
    <dbReference type="GeneID" id="119725021"/>
    <dbReference type="OMA" id="GTCFRYI"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918660" description="BTB domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="635" mass="71685" checksum="1C56C275874E0628" modified="2023-02-22" version="1">MLFKCCVWTIGTLIVIELFSNSFFEAEGCSSAGIPNEKTDGIVNLNVGGCLCTTTRSTLTRYPDSMMAAMFSGELEPSARDANGAYVMDRDGPIFRHVLNFLRQGKLILPEDFKEWDLLASEADFYQVDTLVEAVKAEKYRRDATRSVNVGGYKYTMNLSALTRYPGSKLAAMFSGEFDPPVLDESGAYIIDGDGPIFRHVLNFLRRGRLILPEDFKELDLLATEADFYQVGDLVEAVKEEKYRRVIPEDETKNFEYIKLNACVNVSYTYTFTGSRNIPWCQPLREFFREHSHSAVYQDRGNYTLNLPLDIKTNVHADFERRKGAMFKGILGSGYGFILKERSYTLNPAGVKEFKWTFARLENDMASPAKVDKRDKKDDTFYLNVGGSLYTTKMSTLTRYPDSKLAAMFSGGHDPSVRGASETYVIDRDGPIFRHVLNFLRQGKLILPEDFKERDLLASEADFFQIPDLVAAASLRKVVLTSPPVADDPKKEFVEFTEQDNKSCRYRGSWETFEQLPREFLAVFEAAPSFPTFSYGKQLRSLEEMRSGVEMFGEISGYWGAFSFGQPGATPPHVFGEVVSNNRSELDPPKWMAVFQRASELGFQLLSTSDPGVPGEKSWLFGRKVPPKIVARDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMA0</accession>
    <name>A0A913ZMA0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-microseminoprotein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-microseminoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052877.1">
        <property type="nucleotide sequence ID" value="XM_038196949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMA0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196949.1">
        <property type="protein sequence ID" value="XP_038052877.1"/>
        <property type="gene ID" value="LOC119725526"/>
    </dbReference>
    <dbReference type="GeneID" id="119725526"/>
    <dbReference type="OMA" id="TSGIECC"/>
    <dbReference type="OrthoDB" id="9969981at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1900">
        <property type="entry name" value="Beta-microseminoprotein (PSP94) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008735">
        <property type="entry name" value="PSP94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10500">
        <property type="entry name" value="BETA-MICROSEMINOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10500:SF0">
        <property type="entry name" value="SCO-SPONDIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05825">
        <property type="entry name" value="PSP94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037403255" description="Beta-microseminoprotein-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12245" checksum="C30500D7715929AB" modified="2023-02-22" version="1">MVSHLVALFTCLSLVVLVSDTDAQCYYYDGPCVYDKHHYGMWEMWDTDDCEMCFCDGDFGYECCSKFYVPTVYDHEKCTVIKDKNTCQTRLLDKEGNECESLVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQK2</accession>
    <name>A0A913ZQK2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">35 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin NUP53</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053351.1">
        <property type="nucleotide sequence ID" value="XM_038197423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197423.1">
        <property type="protein sequence ID" value="XP_038053351.1"/>
        <property type="gene ID" value="LOC119725834"/>
    </dbReference>
    <dbReference type="GeneID" id="119725834"/>
    <dbReference type="CTD" id="129401"/>
    <dbReference type="OMA" id="SSYHTND"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12722">
        <property type="entry name" value="RRM_Nup53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="14">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="368" mass="39023" checksum="B8420A250268578D" modified="2023-02-22" version="1">MEYHSPSLSHSMSQSYGHASSLEPMTLGSPTSMGSSHQVPGSHSNLFLPGYLMGEMGPSVSPSSSRLWSSSRSSPPRGVTPSTLGPRDGGSGLGRSDSRMSQSRPAVTRTPKDKTGAPPVAGLFDNVDALKGSPAVGGVYGETPEKRQLDLSMSKTPLPTSSYAAGTPANSRMFSPAQTPQSQFGARQTPSSPAQIDPFYTQGEAITPDVQLDETWITIFGFPPAATSYVLQQFSQYGSIVRHVAASSGNWLHMQYSSKLQAKKALSKNGKVFGGNIMVGVMPCIDKSVMEGGDQCNASTLQSNTPSRYPMTPQAEEVEASQRPTSSIRPLTAAYKAASSNHEVIQGGSTPKKSSNVVSKTLEYMFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZQK3</accession>
    <name>A0A913ZQK3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038053410.1">
        <property type="nucleotide sequence ID" value="XM_038197482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZQK3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197482.1">
        <property type="protein sequence ID" value="XP_038053410.1"/>
        <property type="gene ID" value="LOC119725885"/>
    </dbReference>
    <dbReference type="GeneID" id="119725885"/>
    <dbReference type="CTD" id="6631"/>
    <dbReference type="OMA" id="MMPTGPR"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="17748" checksum="2B855DA0992B70EC" modified="2023-02-22" version="1">MPKYYCDYCDTYLTHDSPSVRKTHCNGRKHKENVRIYYQKWMEEQAQSLIDRTTAAFQSGKIHHNPFNEGGGPGGMPPPPGGAAVPPPSNYGGPRGPMPPRGPPMGPPMMGGPPGQRPLMQNPPGLMSMGPRPPMMPPIGPMPPGEMPPPGGLLPRPGLPISNGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZR01</accession>
    <name>A0A913ZR01_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053516.1">
        <property type="nucleotide sequence ID" value="XM_038197588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZR01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197588.1">
        <property type="protein sequence ID" value="XP_038053516.1"/>
        <property type="gene ID" value="LOC119725959"/>
    </dbReference>
    <dbReference type="GeneID" id="119725959"/>
    <dbReference type="OMA" id="CIDNIGN"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="637" mass="72049" checksum="F3D14878C2A86C1D" modified="2023-02-22" version="1">MAEAEAKSVLGTISRGHLECPICCCRFTDPKILDCLHSFCLNCLDELNSRQQPNADEITCPVCRQRTAVPDTGLQGLPYCFFLSSLVDEFNKQERLLGDAPADTRTYEECDEGLEAVSRCLDCCKFICTKCIEAHERMKSMRHHRIIGKEQNRFDVTTIDPQKKATPQCTRHTNHEICFYCETCKTLACAKCVALDHRTAEHKYKEVADTIRSYRHDVSDILQKFDKSREEFKVADDSLTHARDRLRIMVARACKDINTKEEAEIAKIRYKSRHLRDKVTQIGEERDRKFAEVKKNNRDKMKRADQIVATVNDLMQQADDFELLDLKPKVMHNLNFQKKLKFREAQYELSFIGVKWQDVVLDTDLGEVLQEEKWQLKKEIIENGPGDEQFECAEGVACLSNGNIAVTDTTKKKLMLFTSTRMYKSSVNRKKLSGPCGVAATSGELLLVTDGKYVKVFNSRLKFIRQFAPSHDDADVDSKSDLTGIAVDKKNRIAVADSGRKLISLHHLDGSLITTISNDMIDSELTIGIRKRLIYTNYQECKLICITYTGDEVFNVNTSLDGETVRPLGVCCDDAGEIYVAVGIREAESSEMHHYSPAGVFIGRVARELHFPCGLTFTQSGDLVVADGVSVKISQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTV5</accession>
    <name>A0A913ZTV5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Periphilin-1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054506.1">
        <property type="nucleotide sequence ID" value="XM_038198578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198578.1">
        <property type="protein sequence ID" value="XP_038054506.1"/>
        <property type="gene ID" value="LOC119726746"/>
    </dbReference>
    <dbReference type="GeneID" id="119726746"/>
    <dbReference type="OMA" id="RFKSHET"/>
    <dbReference type="OrthoDB" id="6287790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22896">
        <property type="entry name" value="periphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="522"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="593" mass="66902" checksum="F83BB3D776805A23" modified="2023-02-22" version="1">MSGLRFQPGPGEDPFSVFFKGFSNAVKAAEVSDYFYDKGYHNRIAYQKIYNQHFRLFMALRFDNIEVAKEVVEKYTNTILFGYKIHLSFFKKQLAGIYTPRINSIFMQDKLRKLRAQATHRPFFYRTRFHGHYSPVRFFRPRPRRRSRSRSRGRSRSSSSDSDSISPDRKRRDRSRDSPTPKRRRVSFVNGQFFTHRSHSPSRSSRSTSRSETPTRFSPSSSHSKRSSSNDKTSTYPNHVRKVCSKVTVVENQHKKFSDSSRSSKEHSQECGSPTKGKHRAQSPSKERFMSNFSPVSFGSDDDAMLMTPTPEPTTTRDPQKGAAQNDQSAASYFTLNKSTPPTEAWIQSEGDTTPDGGTPSPRGPGNLSRGTKHTDKPCHSVYGKVGPFTEIRATDRPWQLKPLTVQDQGSPLSKQTEAQFVIKSPSSRNGSGTAPFGINENNSVGNRIVVQTNRPEAGFIGSPSSTSSSRHPSLSSPPRPHIHPSPHEGAWSPGSNRLQSPTSSFGASPPKVNGVRKVELNQSKLEKLQAKKEEIIKAYKQDCDTFATVVRMLIRKDPELEQRLQHALRENLTEIGQRCVQELQDTVEQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVN1</accession>
    <name>A0A913ZVN1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055335.1">
        <property type="nucleotide sequence ID" value="XM_038199407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199407.1">
        <property type="protein sequence ID" value="XP_038055335.1"/>
        <property type="gene ID" value="LOC119727510"/>
    </dbReference>
    <dbReference type="GeneID" id="119727510"/>
    <dbReference type="OMA" id="DPDHGMS"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18367">
        <property type="entry name" value="BTB_POZ_KCTD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22204">
        <property type="entry name" value="H1_KCTD12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057093">
        <property type="entry name" value="H1_KCTD8_12_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23110">
        <property type="entry name" value="H1_KCTD8_12_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="29683" checksum="C6646EC7AF6EA542" modified="2023-02-22" version="1">MSIVNRIEPTASCECRVSNMSSDAEFPAVVELNVGGQLYTTALSTLTQQGDSLLTQMFTGRARGPLQRDSRGRYFIDRDGSLFKYILDYLRNQKLVLPESFCERGRLRQEAEYYRLPRLASALSETAQADSTADNVGNSVSGDRSDSPGFLTIGYRGTFAFGRDGLADVKFRKIQRILVCGRVALAREVFGDSLNETRDPDRGMSSRYSARFYLKHVYLEQAFDLLATRNFKFVSCCASGTSSGPPESDESKWNHYNEFVFQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWA6</accession>
    <name>A0A913ZWA6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055804.1">
        <property type="nucleotide sequence ID" value="XM_038199876.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199876.1">
        <property type="protein sequence ID" value="XP_038055804.1"/>
        <property type="gene ID" value="LOC119727809"/>
    </dbReference>
    <dbReference type="GeneID" id="119727809"/>
    <dbReference type="OMA" id="FKFNRRN"/>
    <dbReference type="OrthoDB" id="6089225at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="486"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1566" mass="177363" checksum="C5975F7DF07DB31C" modified="2023-02-22" version="1">MPTTPGATQTASSSNVSEQYKKPHINPPAHFNASAKDAAEEWKMWRQMWDNYCVLTNLASQPEAYQTALLLHSIGTEGVRIYNGMKFDNPADNQICSKILEKFDSHFLGQRQEFFERFKFNRRNQDEGEPIEQYISILRTMSKTCGLCACMKDKLLMDRLLMGVLDDKMREKMMATHDLTLTKAIEICKAVEVATVQMKAMKKEETVHKVRPKKTDKKPRQPKQRPPRKAPVNEGGKPISKRCKFCSGNHPMKKELCPAWGRTCDSCGVKNHFKKSRVCKNHRVHAVDEDGYTSSSGESVSCVTTDINSVTDDSKPVYCTMEIKGEPVKFQVDCGATINLIPKKYAMEISPARIELKMWNNSCMTAVGRSTIKLRNPVTLKKYKVNFVIVDKDLTPLIGRKAAEQMGLITINYDKFSQVHGVTPTHADFVSEYPDVFNASVTGILPGQRVHLTVSSDAEPVIRPARTVPEALKPAVKAELEKLTDRDVLAEVDEPTNWVSQMSVAKKKSGSVRICIDPGPLNKYLMREHYTLPVLNDILPELNEATHFSICDLKDGYLHCELDDESSKLTTFATPWGRYRWKRLPFGLKVSSEIFQKRLHQALDGLEGVRCVADDIIIWGRDVEEHNRRVRKLLQRCKEVGIILNREKSRFTVHEVHFLGHIISHDGLKADPSKIEAIINMKPPTSKDDVDRLRGMVNYLSKFLPSLSQVMEPINALTRKGVEWSWNACHDKAFGKLKQLLTEAPVLTYFNPEKELVIHTDASDRGIGAALLQNGKPLAYASRALSDTETRYAVIEKEMLAVVFALEKWHQYTFGRHVTVYSDHKPLESIVKKPLDKAPRRLQGMLLRALAYNADVNYLQGKKNLIADPLSRSFLPYESSQKEFETVNALQYLTLPEERIYDIKQMTGSDDVLQLLKKSIQEGWPEHKNLLPAQITPYFSVRDELCVHDGLVFRGERLVIPKAMRQVIKQDLHLGHIGVEGTLRRAREYVFWPGMTDEIRQWIECCETCREYEVSQAPLPLMSHDIPERPWEKLGIDLFHHDGKDYLITVCYKSNFWEVDRLHSTTARSVIGKLKHHFGRYGIPDIIVSDNGPPFSSKDFGDFTRKWGIKHNTISPYNSKANGKAESAVKSAKKMLKKCLATGEDEDLALLNIRNTPTQGVDSSPAQRFLGRRTKTLIPTSRRLLQARGSEGKREMKQLELNQRRQAKYYNQSTKDLPSLIQGDTVRMKPFRQGEDRWKKALVLRKLDERSYEVLQDDQVYRRNREHLRKSKEPPPKQHKPSTGNTLHVPEGCPRTTDSQKEVSIKPDMTPVPPNPVPAAPPTNSKIPTSYDPTTTPTEQPTLRRSTRTRCEPAKFQDYTDFDVPLEVAENPLLDAALPAVIPGLGDEDITTYKTVESGTKRGKVILVDSHSYTYTKKWKKAGSTSSKVTWLCSVRGKLHRCAVSVHQDGNLFHAGVHTKQTHPAHPGADVTVQVKALVITKAKADISKSAGAIVEDVITTHLQPDTPAASCPNPTNLSRAANRHHQSQRPPEPRDIDLIIDQGFIPEHFLQKDIHLGCARHVVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWG6</accession>
    <name>A0A913ZWG6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055862.1">
        <property type="nucleotide sequence ID" value="XM_038199934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWG6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199934.1">
        <property type="protein sequence ID" value="XP_038055862.1"/>
        <property type="gene ID" value="LOC119727860"/>
    </dbReference>
    <dbReference type="GeneID" id="119727860"/>
    <dbReference type="OMA" id="AWICRHV"/>
    <dbReference type="OrthoDB" id="10159327at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="829" mass="94165" checksum="D565380EC31768D1" modified="2023-02-22" version="1">MDDTPSILTDYYRRMTAWICRHVPSAKSGVSHTKVQVLSSTHCVPPRADFNCPSPSKLCDTLASQIRSHRRPGKHPENENRAQDAKLVCSGQDHRASKTVIGDGATTEDAFQSDHSGHLARTHSSTSKVNEIAGNFSGHTRDNHGTVEGEDPPTGCLCLPVLSLQRWRNRRRAKVAPFNPRSPSIKPATTSPSSCEDTRVQPLTTEVSVFDLEDENGQESPGLGLPTRQMMQEDMDEWRQRRRSEILLGNEEDDMKGISRESLSLPSRPKTSKGREGESDRNDQRSERGARSSTEVNTETNEFGAGKQAGKLEFVGSGKSRHSDECDSDEVLYYWKNLDVKDNDEDEDGNRSCVALAQSDEVTTDGDTKWENSLSRMSSLKEVPPRPKTSRGLRPENGQEDRSSVMERSLEEVISTLFREEDGVRDFTRDDVVLDKTHESDSGIQKSRSPLEETHDSCEVLSVWRNPDEMEHKDEEIGHDVSPSKDGECDRGEKTKESSPPGHDEVSHLTCENQKELISPKSSEHSMDADGVMMTREEELQFERQQREQWQLAALGEWATVCQDYDEDEYLSECYLRMDEFQKEQAMMKEWKAISERYHSVGVIQDLQNMQTLCKCTINQSERALRQFARICRGPVPLSKSGQTKAEAIAPLSRMVQKQTRRISENISTTFMEFYQIFEELDVLRERQDRVEEFLLNDLKIRDAEVALSQSSSRCSTITPRQVSSRLQQREIDQDLVDRYMEKYRVRSTDLFEVMPTICENEVFHLEECQELDESEVDFPEYSGMDDVCLDENDVRENDAAEDESSDSNFVKSAGEKEERNVDGAVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXA4</accession>
    <name>A0A913ZXA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056149.1">
        <property type="nucleotide sequence ID" value="XM_038200221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200221.1">
        <property type="protein sequence ID" value="XP_038056149.1"/>
        <property type="gene ID" value="LOC119728148"/>
    </dbReference>
    <dbReference type="GeneID" id="119728148"/>
    <dbReference type="OrthoDB" id="6477838at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036965244" description="SRCR domain-containing protein" evidence="10">
        <location>
            <begin position="37"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="198" mass="21712" checksum="68E10AA5E73F0DEE" modified="2023-02-22" version="1">MKSFIFRLEFVLLIIVCTSPQLSLQMVLTDVRLVEGQPNSGRVQVQIDNSTWIDVCDDMWDDEDGRVVCRQLGFPGLDEHLRGLPIGQQSTKSATRFNCDRSDSTLSECRHVSSDMMCGSDKGAGVTCSGVITDVRLVSEPSQPNSGRVQVQINGSITWIDVCENGWDEDDGGVVCRQLGFPGLAQHLRGLPIAGQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXB1</accession>
    <name>A0A913ZXB1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055930.1">
        <property type="nucleotide sequence ID" value="XM_038200002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200002.1">
        <property type="protein sequence ID" value="XP_038055930.1"/>
        <property type="gene ID" value="LOC119727923"/>
    </dbReference>
    <dbReference type="GeneID" id="119727923"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="11911" checksum="37ADF313FE096621" modified="2023-02-22" version="1">MTNTRIQTIILPKDGSVVHIRPVKRTQIANVGDSVRLEMQHVNAPNKNYRWRHNGRDILTSWNDQLSVSIDDVAVSDGGVYSCFASDQENRQLHGIMRLIVRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZYZ2</accession>
    <name>A0A913ZYZ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038056540.1">
        <property type="nucleotide sequence ID" value="XM_038200612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZYZ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200612.1">
        <property type="protein sequence ID" value="XP_038056540.1"/>
        <property type="gene ID" value="LOC119728390"/>
    </dbReference>
    <dbReference type="GeneID" id="119728390"/>
    <dbReference type="OMA" id="ETICNTE"/>
    <dbReference type="OrthoDB" id="10070386at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF2">
        <property type="entry name" value="PROVISIONAL ORTHOLOG OF THAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36351" checksum="2A2670E5CF3538BD" modified="2023-02-22" version="1">MSPGCCAVGCKNRDERKSRKKGITFHRFPLSQPERAQRWIAHTRRANWKPRPWSKLCSIHFKESDFDRTGATTRLRENVIPTIFDFPDNPKKAGKEIELLEAPPALPKPTAEKPDAPSKAVEKPNITAVHTSLPESHDHCYFTRDTPVVLKRKLDFTCAKLCSVNKRLRMTQQKCRRLEKKVCSLEATIYALQEKRPSAAASLDVLSETLPGIAVELLKRMSRSKKRGKACYGEYPAVVADFALKLMSLSPKAYFYTRKSFDGALPHPSLLRRRRSVKKDEAKELGSEQEDLNAMTELSLVSLMSTEELSQLLLPQTNSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A016</accession>
    <name>A0A914A016_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038057167.1">
        <property type="nucleotide sequence ID" value="XM_038201239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A016"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201239.1">
        <property type="protein sequence ID" value="XP_038057167.1"/>
        <property type="gene ID" value="LOC119728803"/>
    </dbReference>
    <dbReference type="GeneID" id="119728803"/>
    <dbReference type="OMA" id="MIADAPM"/>
    <dbReference type="OrthoDB" id="9976756at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037631386" description="receptor protein-tyrosine kinase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="285"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="464"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="471"/>
            <end position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="768" mass="85561" checksum="C93C148691AB4D98" modified="2023-02-22" version="1">MALGKRSSCGYLFLIVSFFNKCCSDPPSAVTLHVNTTHSCESDTECSADVTIGSRYRFACNASGSSPASNITWLINTKARSGMGQTEISPDWSQSRQGETNEDWETSSRIDLQILPEHHQGSIACRATFPDGGTVFREITVKLIADDKHEVLLLAILIPTAVAVFIVGVVATVGKLRSNIKGERARGYRISTQEVILSRVSPYEIEGQETEFKCTLRTDQCQSIPQYFFWLINGSHLSDGPELRRSCESRLKKKLYRDQTGSTLMCVSQPASKNASLTLNVMYPPSAMTLQVNTTHSCESNTECSADVTIGSRYRFICNASGSNPASNITWLINTNACSGMGQTEIPPDWSQSRQDETNEDWETSSQIQLQILPEHRQESITCRATFPDGVFRERVMELIVNDKLDELQLLAIGIPAAVTVFVIVVIATFCTLRSNAKRKRAQEVTEVMEEGTMKKCNFPRSKITLFDVIGSGNFGQVFRATADGILQEGVETEVAVKVLKESADEAAACDFKKEIAIHKTLKRHPNVVSMFGCCTDSEPFVIILELLPGGSLQGYLRNKKKAWTEEAVEGAKPVPPSELLAFASQIASGMEYLSSVGHIHFFFLQCIHRDLAVRNVLLDKDMVCKLSDFGLARDVSETQHYEMTSMGMIPVRWLAIESLLDDVYTTMSDVWSFGVLLWEIVTLGAHPYRGMHARDVIDSIERGFRLPNPTHCSEQLYEVMNETWQETPSERPTFRELRETLEGMIPDAPIYLDMANFVADHYVGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A133</accession>
    <name>A0A914A133_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057061.1">
        <property type="nucleotide sequence ID" value="XM_038201133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A133"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201133.1">
        <property type="protein sequence ID" value="XP_038057061.1"/>
        <property type="gene ID" value="LOC119728754"/>
    </dbReference>
    <dbReference type="GeneID" id="119728754"/>
    <dbReference type="OMA" id="QECGIIG"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="345" mass="37496" checksum="193964D68656D894" modified="2023-02-22" version="1">MLQATEIKVVAIFILLGAALLFGLAPVCLFSKSSMTDPKHRARLRRVVGWLNAFAGGVFMGIALIHLLPEARRLLIDAFKMQNMMYHFNWAELIAACGFFLIVFVEQIVYLCQERLGNNDEASEEVAFADKDRSPSDKTYTNETSPKSKSDVKSAAAEPDIDDAGDKTALTPASSTEDDPMNLPVRLTTLRAVILLISLSLHSIFEGLAIGLQLTRKDVIDIFIAIALHKGIEAFTISISFAQTYASHTAKTVYCVAFALMSPLGVAIGIPIAMSTRNQQKAVPGSSLMINAILQALATGTFMFVTFIEILPHELNSKKDGLLKFVSIVAGFAAISALNAIEHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2K9</accession>
    <name>A0A914A2K9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 20">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="20">GNT-I</shortName>
            <shortName evidence="20">GlcNAc-T I</shortName>
            <ecNumber evidence="17 20">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16 20">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="20">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Golgi apparatus membrane</location>
            <topology evidence="1 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="17 20"/>
    <dbReference type="RefSeq" id="XP_038058082.1">
        <property type="nucleotide sequence ID" value="XM_038202154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058083.1">
        <property type="nucleotide sequence ID" value="XM_038202155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038058084.1">
        <property type="nucleotide sequence ID" value="XM_038202156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2K9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202154.1">
        <property type="protein sequence ID" value="XP_038058082.1"/>
        <property type="gene ID" value="LOC119729549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202155.1">
        <property type="protein sequence ID" value="XP_038058083.1"/>
        <property type="gene ID" value="LOC119729549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202156.1">
        <property type="protein sequence ID" value="XP_038058084.1"/>
        <property type="gene ID" value="LOC119729549"/>
    </dbReference>
    <dbReference type="GeneID" id="119729549"/>
    <dbReference type="CTD" id="4245"/>
    <dbReference type="OMA" id="KGYDLSW"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02514">
        <property type="entry name" value="GT13_GLCNAC-TI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.20:FF:000001">
        <property type="entry name" value="alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="10 20" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275666" description="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" evidence="22">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="53823" checksum="3695DD700673F179" modified="2023-02-22" version="1">MALRRQKLIGLGLMLFLLWNVAAYLLFARQAEQGTKPLDESEGMNERLQRLQEQMQEQMQINEQLLHDIVQQKETIIKSRNQSPDQPNLLPAGLDMVAHQEPKPSKTNPFQLPLAKQVKYPYSSYAIPVLVIACNRPSAITRSLTNLLEIRPSSAQFPVIVSQDCGHQATAEAIQKFGDKVTHIKQPDLSSITLPAQQKKFEGYYKIARHYKWALNKVFHEFNHDAVIIVEDDLDVSVDFFEYFLATYPLLQEDPTLWCVSAWNDNGKEARISDDAELLYRSDFFPGLGWMMRKEVWLELEPKWPQGFWDDWMREPSQRKNRACIRPEISRTDTFGKVGVSRGQFFEQHLKYIKLNKKSVAFTNLDLSLLKKENFDPVFKKEVYGVPEVTMEQLKQNTLSQKTVRVTYTNKNSFKLLTKQLGIMQDLKSGVPRAGYMGVVSFMFNGHRVYLAPTKDWKGYDETWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A556</accession>
    <name>A0A914A556_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058987.1">
        <property type="nucleotide sequence ID" value="XM_038203059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A556"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203059.1">
        <property type="protein sequence ID" value="XP_038058987.1"/>
        <property type="gene ID" value="LOC119730252"/>
    </dbReference>
    <dbReference type="GeneID" id="119730252"/>
    <dbReference type="CTD" id="6625"/>
    <dbReference type="OMA" id="GRTTKGW"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000153">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="478" mass="57258" checksum="526ECA3602E51B16" modified="2023-02-22" version="1">MTQYLPPNLLALFAPRDPLRYMPPTDKLRHEKRDEGYSGMAEFVRIFEDPKDTPPPTRVETKEEKKERKRKEKNESHRAKLEDEITTWEPSAGGIGDPFKTLFVARINYDSSESKLRREFESYGSIKMIHLVHDKKSGKPRGYAFIEYEHERDMHSAYKYADGKKIDGRRVLVDVMREGTVKGWLSRRLGGGLGGTRRGGPEQNVRHSGREEPSQAAAARDEEDRDMDRRERPRSRSRDRDRDRRRDRDRDRERERRDRDRGDRGDRGDRGDRDRDRDRDRDRDRDRDRDRDRDRDRERRRREREREREGERDVEKVDGESAEVIDDKDTDPNLQEVLEKDRDRDRDRGRDRDRDRDRDRDRRRRDRDRDRDRDRRDRDRDRDRDRDRDRDRDRGRDRKRERDRGDYGDGEEPEVKVKIEEVAEGQGDMGLVSYPADEDEDSSAATDAYGVKIKKEKLDVGYGDVEPQNGMEQEEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A5P4</accession>
    <name>A0A914A5P4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058824.1">
        <property type="nucleotide sequence ID" value="XM_038202896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A5P4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202896.1">
        <property type="protein sequence ID" value="XP_038058824.1"/>
        <property type="gene ID" value="LOC119730120"/>
    </dbReference>
    <dbReference type="GeneID" id="119730120"/>
    <dbReference type="OMA" id="CAYCCAG"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF31">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="132" mass="13868" checksum="326250C6A31A84C3" modified="2023-02-22" version="1">MYNAYLRHLNVLDVLCLIYVVCFSLLVVAVGEAFQCFVCSSVTGTGCGDPFDASAQSRYRVACPATSICLKVTSGSTVARTCGIGNACAKSYECQGDNCAYCCAGDSCNSAGTVGFNLVLAAAMLVLTRMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A627</accession>
    <name>A0A914A627_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059195.1">
        <property type="nucleotide sequence ID" value="XM_038203267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A627"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203267.1">
        <property type="protein sequence ID" value="XP_038059195.1"/>
        <property type="gene ID" value="LOC119730395"/>
    </dbReference>
    <dbReference type="GeneID" id="119730395"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="104" mass="12425" checksum="E916CE3CB4DC7D95" modified="2023-02-22" version="1">MQQHFTSVIFKIEIQNLPRHFEFAQLKKMLTGLQLEPKKVKAVNKATYAFVTFRLNNTVTPLWNQPYEDQLSTKQTNTRKFLRNLSKMLQRNIGEMSPWLKQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7E7</accession>
    <name>A0A914A7E7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059374.1">
        <property type="nucleotide sequence ID" value="XM_038203446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038059375.1">
        <property type="nucleotide sequence ID" value="XM_038203447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7E7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203446.1">
        <property type="protein sequence ID" value="XP_038059374.1"/>
        <property type="gene ID" value="LOC119730495"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038203447.1">
        <property type="protein sequence ID" value="XP_038059375.1"/>
        <property type="gene ID" value="LOC119730495"/>
    </dbReference>
    <dbReference type="GeneID" id="119730495"/>
    <dbReference type="OMA" id="MFIMIPA"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="355" mass="39438" checksum="911D83B2DEC873AF" modified="2023-02-22" version="1">MPGKVKGLMDRLHDGESVVIAEGYLYVFERRGYLQAGTAVPEVVLEYPEMVRLQYEEFYRAGSDVVLAFTYYAHREKLSLIDREADLEEMNRTALRMAREVADKTGSLMAGNICNSNIYVPNDPDITAKIKSMFKEQIEWAVEEGADFILAETFSDLGEALLALEAVKTYGKGLPVVVTMAWHKNEVNGRPATIDGVEICETFKQLEAAGADVLGLNCARGPTTMLPLMEEVKKCIKTPLAAIPVPYRTTKAEPNFQSLTDPLSGKRLFPEDLNAALCSRSDIKEFGRRCLELGIQVMGVCCGNECHYTRTLCETLGRKVPASRYSADMSKHYIFGTSEKLSTRYTSGEGKQHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9G7</accession>
    <name>A0A914A9G7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060495.1">
        <property type="nucleotide sequence ID" value="XM_038204567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9G7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204567.1">
        <property type="protein sequence ID" value="XP_038060495.1"/>
        <property type="gene ID" value="LOC119731396"/>
    </dbReference>
    <dbReference type="GeneID" id="119731396"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037414471" description="F5/8 type C domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="101"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="29180" checksum="4BE28610DB2BB448" modified="2023-02-22" version="1">MRRLALAALVACVFVTLMSEVLAERVCYFSQEPDARQPGRLRWFMPGSKEDRCACTSTRPGSVYMQPLHWSHPPFYTDTPIFTNDPEDIHDYFNCHGDSSCSVEGPLGMEDGRIPDERITASSFWQNRADHAPPRARLNIQGYAAAWCNEETTDNISPWIQVDFVDTVTITGLITQGRGDNDQRVTEYQVTYSDDGQSWHHVTDADGTTMKFPGNKDRNTLVTTRLPFALRTRILRIHPTAWNLYCSMRFEVIGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AA61</accession>
    <name>A0A914AA61_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038060653.1">
        <property type="nucleotide sequence ID" value="XM_038204725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AA61"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204725.1">
        <property type="protein sequence ID" value="XP_038060653.1"/>
        <property type="gene ID" value="LOC119731548"/>
    </dbReference>
    <dbReference type="GeneID" id="119731548"/>
    <dbReference type="OMA" id="ENIMGIC"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CARD" evidence="21">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="439"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="798"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="24">
        <location>
            <begin position="982"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1125" mass="128019" checksum="C879689B1846E7CC" modified="2023-02-22" version="1">MDSSPNVLLTEVFRTQLINHLSIDPSLLAALVQSSIISSEEHEKILTDASNPDKTQRLLRIIHNHPSNVVSQFVLALKNSDNATNTQLADYIEGTSNIPEYGKEHRLIKKYYRKLVQDIDPSAMIPYLRYIPPNVKENIMGICARGDSDLARCMLLNLTLRTLEPQWFDQFLAALEQTGQANVARKLRADFEKDEAQVAMEIPAELAFGQPRSPDLNLDALSLEDRRMDRMSSMEMRASGSSMSGMRHSNHSQQERRSQSMGPPTSIPQERSRSSSKRSRPVPSRKSSRSPKRQKTYQDKMELFKRIRGRSNQRGSTINNVIQQNFQNIYNNTTNNTMNVSNSQNVQAMVGGEGNIMNIGDRRNDPSPTRGREADLQQCRRPAGEDEPDRAKVPRCDDDVGDMYGPPSANGHIPQEDCTKSDVPMVDRPVLFEDQLELAENAVTGMNTVLVAPTGSGKTHVAAYIIHDHFITDRPKPVVERRALFLVTTVNLVGQQQEKLKDLLKPAVFFSVIGIHGASELSLKEEVTNRNVIVLTAQLLENALDHIPLERFSLLVFDECHLCQKGHAYNTIMARYLEEKLKGNHNLPQIVGMTASLGTGKAKRQDDADNHAVQICANMDASCISMVERNIEALEERVNIPEEVEPIEVTCREVDPFADKINEIMEKIEVMLKESQSPEVQWFIRSACIPSVRGSQAYRQWCDRMKRNAQIFIQNGQDEIYRQLQACICHLMDYNKSLVINKQVRTVDAFKHLDNMMDKMNDRRSCFDDTDYQLHKLFTSEERILREICDDPSNENPLLVKLREIILEEYGMRPDTRAILFVKTIDTTEALHDWITETPQLEFLTPGRIAGSRDMNSDQQNKVMAKFRGGEHKMLVATNLLEQGTDVPACNLVIRLDYVPSDFGHVQIKGRTRKKGGRSYLITLIESKGAVRDAANRQREVMMMEAARNLKEKTPGQFVCAMERQQEDDRLERQARQKQKREIRRDNGGATFAFCCINCSMVAFQSHHVGIYVESQFLILDPDFGSRMEIREHPKPKKLGKDITVIGKMFCKICGHDWGALTRIQDSYYPSVRICRFSLKNLSTQEAHTYKKWKEAPFEVAKVTVLPLEAKVKVPINILKKLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAR3</accession>
    <name>A0A914AAR3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038060952.1">
        <property type="nucleotide sequence ID" value="XM_038205024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAR3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205024.1">
        <property type="protein sequence ID" value="XP_038060952.1"/>
        <property type="gene ID" value="LOC119731767"/>
    </dbReference>
    <dbReference type="GeneID" id="119731767"/>
    <dbReference type="OMA" id="LRITRWG"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="40"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="512" mass="54965" checksum="F2F97DE66E3159C2" modified="2023-02-22" version="1">MCHTSTMAEDTPRENDPKNRDPCRGRGCGQLRITRWGRVVVVASFLTFLLHNGVLGTFGAFIPLLLKEFQQGSGQLGWVVSSGIAVENFAGPVGNMVARRIGCRRAVMLGGALLACGTATASLATSVYHLFVCLGLIAGLGGSIIHVAIVIAVGQFYSRHYTVANGIAYAGPGAGVFVFPPLIEYLNETYGWRGSLVIEAAIVSNVMVMGALFRPAAWFKSRRSSVVRDDEVRRQLDYEPLATGQMQSGIRDGSYEDDGSSDSGISELSLETKGSRRSSTIQPPGSERDFSSKSSTKTTKTYRRKSILTQTNTPAMLAMCVACVFHTAGYSGISVHLVNQAVSSGMTIQQASLLLSCIGIGSLVGRLSHGWFLTRKYITPSWMYTLSLLVSVVATAMLPLTTTFGGKIVLATAAGFCSGVYFSLVAVILRELVGILYLGVAFGASLFCSGLGTLLGGYVIGVLKDVTGSYCIPYYLVSVFFAVAASFSLPRPVIQWYRARNKRRQEPRPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ADB3</accession>
    <name>A0A914ADB3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061471.1">
        <property type="nucleotide sequence ID" value="XM_038205543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ADB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205543.1">
        <property type="protein sequence ID" value="XP_038061471.1"/>
        <property type="gene ID" value="LOC119732143"/>
    </dbReference>
    <dbReference type="GeneID" id="119732143"/>
    <dbReference type="OMA" id="QYTCLNI"/>
    <dbReference type="OrthoDB" id="5915222at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030368">
        <property type="term" value="F:interleukin-17 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039465">
        <property type="entry name" value="IL-17_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583:SF7">
        <property type="entry name" value="INTERLEUKIN CYTOKINE RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15583">
        <property type="entry name" value="INTERLEUKIN-17 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038022882" description="EGF-like domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="892" mass="100362" checksum="2E73091042F977CB" modified="2023-02-22" version="1">MFGACVVLLSVALMGVLGEHSQPFFDPDCFSSDCSWSWDTPTPGHQFCERIIYNNSLINVCPNPFDPPADQNERPAKAQEVVVTDFNKLFRSSEDPGKFEQYTCLNITYKILKNAADKVKGLQLSVLGTDQPDQNRNYCLNLNFTDQGLDFYAVEDRVFSMECFCGLKPGSQYLYTVRTLPVDPNPVDEDDTKVQDYHRPPNCDDPSKTDDVRCQRSIEARWSPDCFGADQLITSGEYDNLEVKFDVAPMNYNFDYYRIFIYEYVPNSPTLIGGPSKLWTEVDRDDAADGMCSQDIVSMLVHKFNISALVKSPDTEYIAKVQPRPSENQCLDAEGATTSCTTTNSLPFSLIADPCKRNLCGEAGQCRSQEASYSCECDQGYMEWSQTCVVDPCMVLAENGQDWLPRCENGECQYDHMSIQIDYYCNCNEGFDYLKTPKTCVANPCTDSEETGLTVCGAHGQCEKNLTDDQVSHKCICDEGYTFEDGECQEGMSVGIIIGIGIASCVVGLLLFVLAFCLYRHHRNQPGDPREFRPPGPGPRGQPDQYRYRRVLPIYSEDHPHHKEVIHCFCRFLKEHCKCDVRLMDWQKSVSPTVGMWLAAEIDKADIVLLICSKGTGKKFKDKARQKMTPSSDGVYGDVFIQALTLLDAYCSTDDACEKFLVCFFDYSSEEDIPMSFKRFGKYHLMKCMDSLFLRIHDKVKDSPSSSRRVKDLEEASYADLDMGKPLHDAIENMKEQIKREPKWYKKYNKGNGTTRETSLEYNNTSLSQQPLLNSLSPQISTDSAYDSTAAAQISDDFFRDTASSGCSSTGSDYEISLRKFQSVPVSDVAVVMPPHHDKDVDDPATRFFSDDIHLTMNPGPGDPFQSSDFYSDVQVGDDVTTRQARAQSSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEF0</accession>
    <name>A0A914AEF0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Insulin receptor substrate 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061871.1">
        <property type="nucleotide sequence ID" value="XM_038205943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AEF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205943.1">
        <property type="protein sequence ID" value="XP_038061871.1"/>
        <property type="gene ID" value="LOC119732430"/>
    </dbReference>
    <dbReference type="GeneID" id="119732430"/>
    <dbReference type="OMA" id="EYEVMAS"/>
    <dbReference type="OrthoDB" id="6537982at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="108316" checksum="1C53038C138870C3" modified="2023-02-22" version="1">MADHTNPLLQCSLKIRRGRKWKTRWCELTKLSPVSDQIVLKFYKGQDQLLSGKEIRREQIVLSAQNFCGVESCVRHPKNPFVLTIICLDQIVLLSFACHKDLLTWFEKTYVTLGNAATKFKCTVEVPNGGRLRPGPGLLYFHDNHFAITDEVPSRLIGSWSLANLSRYGIIEEGFAFEVRSTSKDGGAFVVITQHAESLKSHFDAATCSPSSNRWSHVSSTVSIHEELAPRRRDFSEEMRCLLASSRNNDHQSGGNSPGGTYPYPSGTNPTQVRSPAMLEHCSNRRNQLQRNQALGGRFIEMIEMDQSWGVGGGSSGSSSGSSVETIFNTCDGLRSPKKTTPIREQNYEVMASFNHLREAEDSSNGNAPHIGDLHEACAICQGGKKSQSGDSEREEHEYVNLPPPKNGKRSNQQGPTDGENLNRSHVHVPALETKLEKAEKQTPTFASNSAHARSMSLPLNEDYLLMKYHESENSKPAASKTGKTRSLSVQPSMERSDNLPAPFDDLLPASTLQGMLEDLPNTGKRSRNRSTSRDIQSDIPVPFHHGDLVKPVGPIAMLRLNSVSSSSSESVSSASESLLDAQISRGASFSRPRQSSVGASYQRGFAKIHSRSHDERSSSPPVDVATMKFPSRKSDPDFQRMLGQRDEDSETFVYARKGSIERRPESPISSAPSVTSYITRRRQSFQRAENSLDETKGRSLEDKSTMNVQRRKRCNTDPSVVFTTPGDGTAWCRDPKDDEDAEGDGYLIMKPVYEEKLKRFQSRQQSSPVIQAMPQSPLHSGEKTSFLQSKLKRSATVSGEVSALSPTRFSQRTMSLRERPARTAATPPRDRKSSMSFMDRFLRKRGGSEGAVKLDISRPRHKHNYASIDPENVARRASLKSRMESIDNPVEVDILDDEEFSESLNQFMTENPRSLADNSGTSSAPSSIQYNQIEANRRQSMGQDTGINFTADVDAVVFSEDRKVESSNEYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AEL5</accession>
    <name>A0A914AEL5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062390.1">
        <property type="nucleotide sequence ID" value="XM_038206462.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206462.1">
        <property type="protein sequence ID" value="XP_038062390.1"/>
        <property type="gene ID" value="LOC119732856"/>
    </dbReference>
    <dbReference type="GeneID" id="119732856"/>
    <dbReference type="OMA" id="GDHYDSF"/>
    <dbReference type="OrthoDB" id="8197715at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038891">
        <property type="entry name" value="FSIP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47315">
        <property type="entry name" value="FIBROUS SHEATH INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47315:SF3">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2199"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1569"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1597"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1702"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1761"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1883"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1957"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2092"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2122"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2137"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2231"/>
            <end position="2254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2279" mass="250872" checksum="987659911AAF0DE4" modified="2023-02-22" version="1">MSAMNTPSKTGKESESPAKDAGEYLSALAGGKSPISLPSIPAWMLNTPMYSKLPMIPAPKGKITLYTTGLGEKLYPTPNDLDFDPSAEGLSSEYKTLHDPHLKSHYTQPATLQGLIRRKFVTPEGKVICTLKEFNDYHQYLKRVHIEKCAQDRKSIAMKERKERERQRQEWTMKEGLSPHDKQVLETQTRKRKTLKEHHRHLLQRLEEDTVKHLRVLEEKQTKRSIERARRNLEREKKRNKRLRWELEEHIKKGTKRMNLAEDEIRHAELLKCYNVSVTQRRELKLEDQWNRHQKIREKHRLEAARRRKEQHTRFAQNIDSREQTASDKWSKQLSTFDNMREARALKMQRQEAKIEARLEKKLKSVRKLFEQRRRKPIGGRRRRPPRHGLGGPRHYSTWPVEHALDRIELSPADGVWKIITDRYLPTAAPTTSPAPSPTGFLEPTITIETEEKLPISKDILAEIAEEESVPDVQEDRGYSISSIEMAVLFGDHYDSFIASARDLVGNVLHALEAERRSEEHVPEAVESVVTEPKETKLPEVMRRKSVLQLTNSTVARLVLSNVLSRAKEQITTEGGLPHLPIATPTRKVASDTIATKKPSVGKQASLREIHPPSPIAKSGVMSDGSIQPKETPSPKHTSSSLLAAALVSDALRKVTRELEEESQRSDTSVFVEDMVWDTIRNVTGQLQKELSENVSRELEQESQRSDTSILAEDVVQNALRNVTSQLQKELTESGTSFIAQRVVSDAIRNAARQLREMRLTQSSSSVLAEELASTAIRDATRQLQVLLPQTSSSIIAEAIAADAIKSVMRQFGAQPPQTSSSILAQAFAADALKNATRRLEGEQIVRALHQPVHASSSLLAQAITNDTIKKVTRQLQLEREALIPHTSSSLLAQAVTNDALANAARQLEHEPRVPPPHSDSSLLAQVVTREVLLNGTVRLQVEKLLQTPQTDSSTVAQQITIDALQNAAAQLPENGAQLSRTSSSRLAQITADAALQAAKEQLRTDRASSRCRSRGSRSSSPFSPDLAKSAVNQTSPEPTKKGTKTRAVASDIIKRAAVDMESQSPTNDLKTPSPLPGQVAADSPDLELDVDDTPDQEFDGLSCQAQTIVMHLVDGAIASYQPKDEEDIEEENELEKSIDVHRSSLLLATVNDVFRESETDVSHHHHSHSAASESEGSDSEEEVDEEDEIIGVIENEIIAEEESVHSLAECLDGSKVEGLTSVVKKSHDKTVFEGAIIPHDKAHESVTEKVLSVEELHKDESGHLVHDASSKSIHKVAEGGESSQEQIHQSRHHYSSIVPIYHTHPLNLDKEIIAHNLSAISMKPDNKHKVPSAFSASSRNSFRNMFRPDMTHCQGSAKCLKDTLVKELSHSQHGQHDQIYGVLEQPHEDITAHHSDEELVGQEEVGGVCYLPQRRRYRTHEVMEDVVAEEQDEVVEEGGRVSPEASQETKDTPAGGDFKSPTEEEVEPILPMSRASTRSIRSGKSREIKSFQSKTESQEESASPSTNKSPTKDAAKSKSTTETKTSSQVPASRSVIGAVIERISSIFGRKHSTKIHPWSTDDHTAEVTSSQTQSRDQSSIKPDTGGKTVDQAYPFEKSDTKRELSDAEVADVQSTPASAKVADEDPDQNHEIQSTKKENTDVYTEKSVETSEVDAIHIPEKTESEPSGERIEPIGPNKQAKQREAVRQPTTDMNKIAEAGTGKEAEKETTKADKTIIKSIELPPETQVRSPAPCTGPEIVQPGGDKVEDAGEKSSPVQRKSSERGEKKKRDSKKSHKSGSESSLKEGQGRKSKTPKPSLSGPLTRPVKSSSAAFGRRSQQRSLTSASPKPRACASSPQSTKAHLGHAKISTQSSQQQMIGSEKAPSLAKPSSGSSMPCVVKQRSQVTKPPSTGSIRLIKVSPAPSMSSARRRSGKLSSTSVGKLMSDKASGGSVRLIKVSPAASTVIGPRRSSRQSTSGAVVKASASSSSNSSPIGVQKLSRDKPKSVSRKASRGSVQSPSKARVLSIKSPQASRPDEAKQAGLVGSRPSSTGSFVIIKTPQETPSTKDNTIASCEPDAVTEAPSQHQESTEQEQAKTDSVQEPLPQSEVVNKEGERQEKAVDAATEESPIGNEEPDMPVQESQTGQPQQLEEPLVSERESDEPKTPVSSPAGNQLAERSCDSSGSQSAKASRRSKSIISAVIERLSRMFSGEYRVIESSIEERHRSDTQMGARSRAGMQGGDEGKVRHSQSTDAVLHTQSTPDGKKNGIQTHSRQRKSSKSVVVRDIKMCKPSFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFM1</accession>
    <name>A0A914AFM1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062301.1">
        <property type="nucleotide sequence ID" value="XM_038206373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFM1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206373.1">
        <property type="protein sequence ID" value="XP_038062301.1"/>
        <property type="gene ID" value="LOC119732725"/>
    </dbReference>
    <dbReference type="GeneID" id="119732725"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="105" mass="11798" checksum="D42DC032FA4D0CC4" modified="2023-02-22" version="1">MCIIMARSHQLQIHMFPASCQCALQQHHSVCQYLNVVQKSSTTNPHVSCQLPVCFLTASLCMPVFEHGSGKDADSLADEMKQCQPIYYHSVSNIQPYVIQDEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFT9</accession>
    <name>A0A914AFT9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein brambleberry</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062239.1">
        <property type="nucleotide sequence ID" value="XM_038206311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFT9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206311.1">
        <property type="protein sequence ID" value="XP_038062239.1"/>
        <property type="gene ID" value="LOC119732677"/>
    </dbReference>
    <dbReference type="GeneID" id="119732677"/>
    <dbReference type="OMA" id="FCHVHVA"/>
    <dbReference type="OrthoDB" id="5978806at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF1">
        <property type="entry name" value="PROTEIN BRAMBLEBERRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037228408" description="Protein brambleberry" evidence="2">
        <location>
            <begin position="20"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72924" checksum="F4E6AEFD8F073B36" modified="2023-02-22" version="1">MKLLFVIGILPVLCLGVDGSFISWIFGGESSPRPEISDEQTTSDPSAGSSAASSRRAPFEMKSAEHRFLKAGEDYMAGLSELDTCHHRVIADLETSCNDITEEELGKLGVALLNCQSQSEGRPTFTCTKDMTLAECTRGMDATTWNTYHIISDRSRSVCYGVRQQQFQRQTRYAVNQLAATAADQLNVMENLMDGQDALQSVASDTLQIMSDGQQEIIQKQAAMKDSQGELQQSIQGNLQDLTSEKALIAAGHRELAQMTDNIRQQLDNATKQLLNQDQDIRQNHKELQKDLTSIHRKAKEAFDKLDGNMQHVTFFQDETFQYYKETIDNLKKMNDTINYLLNLVNDMQTGIDERLGWLTSLVGGLGENLTLLSTCVTHCAYFLLASLCVTFLHTPTFSRIVLLLLVPLNAISEVKHGASLDFSGLTILITGVVLANWVVLLILKYQGSWNAALGTKPPADYTPASPCQCKHVTPRFIMPPAVNRSLGSLGDFSDDEDYTLPTDLSAITGEHTSHMFNSGMLSESSAFSNDTTLTGSNVTDNWFTTLNNDKSVDKMNDVRGTPMDSSLKTPMPSSPSILGFGDLRHTNPARRHLAAALQELPKPVPSPRSQREGTPSSSRPSTPGSSRASTPGKRLCNGITKSGQPCRLACSQGSDYCFRHADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG18</accession>
    <name>A0A914AG18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062673.1">
        <property type="nucleotide sequence ID" value="XM_038206745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206745.1">
        <property type="protein sequence ID" value="XP_038062673.1"/>
        <property type="gene ID" value="LOC119733168"/>
    </dbReference>
    <dbReference type="GeneID" id="119733168"/>
    <dbReference type="OMA" id="MDTLWEL"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="253"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113817" checksum="5D6CACB3579FE9CF" modified="2023-02-22" version="1">MDAQSEAACQRTDVPTTLQQSEAACQRTDVPTTLQQSEAASQQTDVTTTMQQSEAASQQTDAPATMQQSEAASQQTDAPATMQQSEAASQQSDGPTTMQQEAQVHASVPSTAIDSPRPTGTIGNTGTVAGNHNPIIVGSSRVQFNYNFPLEGPGVPAPRLQQSQRPDQEPRLRAPSYQDVGNKTRAILMKWYKKTHSYVQLNPGVPDDQRPIVGIYTKVQIRTKKGTVEEQFTDEIAYSTEYEKIFKCLNDFDRLILFGKGGVGKSTIFDMIAYDWADESNEILNRFKLVFLLKMCALVQESDLVDSTFDQLLGEDSGIAKDELDIFILANPSEVLILLDGFDEMKTKSLDAASFGSVLNALNRTRYRDCVIFVSTRPSHFETLMSKTLVQNPCTHVEVLGFNEEDVKTYVLKFYDKDPDSGNELIQTIGKSTTLRDFATNPMLLLLMCLLWGEKKQLPETTSRLFTKAVNYMFTRKDEDTKTPEKRKANVSGTVIAIGQTALRGLMSANQQFSFQEDEFEPKALDLALKAGILNQQRVIKHRESHNNIQFMHKTVQEFCAAKYLQSVHMSNPGFGKRMVYKVVAFGKFQNYLRQLCRTMEGVYASEFLLSFCSGDNEKCMTDIVKLLDRKFSKDPHRPRYQSNVIRVISQNCFFESQSVNVPRCLTSDSNIPSDIYVRGNNDLHSLIYLLEIFCRSDSHTAKLARIETITLCNVFLVSDIAFSLCYMKNLSKLMLRECPLVKGDLEKTLSSLRNQHLTSLSIKDCTCSALGHTFRVVEWAPHMKHLTSLDTLQISNCDLQGTDMLIVLAEGNVPKLTDLVLTYSMALSGTAELWAKELPTMTLLSRLELSWCNLTATDFEHIVAEVCDMPRLTALILTGNFALSATAELWGKHLPKMAHLNQLSLRSCCLAPTDINHIASAVGDMPRLTSLNLSHNGMTLYTRISVKLWAMDLPKMTHLNRLDLSQCYLTPTDTEHILTAVGDMPRLTELNLEGNNVVGRSAMLLAERLPRLNLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGE6</accession>
    <name>A0A914AGE6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038063050.1">
        <property type="nucleotide sequence ID" value="XM_038207122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGE6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207122.1">
        <property type="protein sequence ID" value="XP_038063050.1"/>
        <property type="gene ID" value="LOC119733749"/>
    </dbReference>
    <dbReference type="GeneID" id="119733749"/>
    <dbReference type="OMA" id="RTATNCC"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="406" mass="45633" checksum="FF0EAE4CB7B4E59A" modified="2023-02-22" version="1">MSDPSTLDSNYSYYDVYYYDYGDCDFAMNFTAEEAIEYSYDTLNELYVRIFLPVIFTLGVLSNLAFLCVVYNVKRMRTATNCCLTNLAVADVMFLVGSVGSKLVKYANSPVSIDDSSLGRAGCIVMYLISDTAYIFSLAAITLVSFEKFYAVCCAHQALGDSRRRVFVRLLVASWIVAFCVAASFIPCTMEYVTLCSGWPSDERYRSWPSQIAFCGPVDDWAIVYGSGAQAIPFLLIFPVNVYLYFRIIVGITRAIKDTSIAGRRQKNIRQRNQIAVMLIVNGAVFFICLAPFEMISLFYMIAYSREEPVFILPADTRQSLTSSARLLAYINAAINPFVYTCMSAQYRDAFRQTFGLGCCSRPGTDAERESVFKRMRRISVNLTASTSAGGSMRIYHSVRPRNIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHC2</accession>
    <name>A0A914AHC2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_038062926.1">
        <property type="nucleotide sequence ID" value="XM_038206998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHC2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206998.1">
        <property type="protein sequence ID" value="XP_038062926.1"/>
        <property type="gene ID" value="LOC119733425"/>
    </dbReference>
    <dbReference type="GeneID" id="119733425"/>
    <dbReference type="CTD" id="5498"/>
    <dbReference type="OMA" id="WFDQWFG"/>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="48"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="505" mass="55556" checksum="B0B3F93BFC3021BE" modified="2023-02-22" version="1">MAVRKVDFLVLGGGASGLSAVFYLQRLLGERLKRVDLVDEKPQFRNKIALLEASPHIGGWIHSTRTPEGSIHEAGPRSMRPAGIVGRNSLNLASSLGLDDEVIPVLRSHPAAQRRFTFTGGKLHQFPSSFATLLTRQEPFSRPLAVDLAREVLVKRSKGEDESMFDFGVRRFGKEITENLIDPFCRGVFAGKTTELSVRSCFPQLFSFERQRGSVILGGLLGPTAIDPTVGESDLVRRAKKERWSIWSLKGGLQCLAEKLSEVVQRNGAEVRTQMPCTKIEFVLKENGGNKKIARVHTAESVWEADRLICGIPAANLAEVLPVDLSPLSLHLQQIQSVTAAVVNLEFEGSHLPTEGFGYLVPSREPSNVLGVIFDSCAFPQHDRPEIKSTRMTCMMGGAWFHDLFGDPDKVDCDWLASVALATLKTQIGLSAKPTYCRVNLSKDCIPNYKVNHHRLLETIDAYVADNDLPLTLVGSSYKGVSVNDCIYNSRLAAQRLVPDGQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJ33</accession>
    <name>A0A914AJ33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 49</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063566.1">
        <property type="nucleotide sequence ID" value="XM_038207638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJ33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207638.1">
        <property type="protein sequence ID" value="XP_038063566.1"/>
        <property type="gene ID" value="LOC119734257"/>
    </dbReference>
    <dbReference type="GeneID" id="119734257"/>
    <dbReference type="OMA" id="DNENEPC"/>
    <dbReference type="OrthoDB" id="1939344at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48774" checksum="06C9CE4889AD690E" modified="2023-02-22" version="1">MADGNIQAKKQQQPSKKTITKISKEEERRLSSTVAKREEEKKRETNKLVVLKEKRRIAINNAARQWEASKSTAMAKTIHLQPGFHSMAREERLSSPDNMYSRPWSGDMETYQSQSMDLPDDKSGELSRASMHSETRTCSKAPTPDLLANISSEACHLAELDGDTLYLYGPGSMEALDKSWGIQAAGSITTISFKFIDFDEITKHLHKIRIRFPNVSTVLFGECNLSSLQQLNALTSVRHLDSINIATEGNPITAFSLWKPYLLFRLSHLDIKKINNEEVFLSDHKHAEDLFTPIAHITTSQLPSSRLLELLGDHCRSNTQALSELELKGKKQLMADQKTTAENVGKAGLQFFCEEAWHDLLQARCCHSTFTCNYVKELVSEAILINKKQSVLEKTWPQVFVQIIHCAVEKMFDIDKYRLTELKTFQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AKN3</accession>
    <name>A0A914AKN3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="RefSeq" id="XP_038063984.1">
        <property type="nucleotide sequence ID" value="XM_038208056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AKN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208056.1">
        <property type="protein sequence ID" value="XP_038063984.1"/>
        <property type="gene ID" value="LOC119734522"/>
    </dbReference>
    <dbReference type="GeneID" id="119734522"/>
    <dbReference type="CTD" id="79871"/>
    <dbReference type="OMA" id="WCTDETL"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="554" mass="62503" checksum="C017EEB306003A5B" modified="2023-02-22" version="1">MFGMSKGAVFSTSEAKISEAAERAMLEERVQRRLVFEKKAHEIVETLLDNPITDEFLLDCAFAICPQHYQDVVIERSIVKQCGYPLCQRSLQNVPQQKYHISRKTNKVYDITDRKCFCSQFCYKASKFFEAQLSDSPLWTRDMEEPLDIKLLTRDMEADATAASLIAKDNVVFTERVESQDVDEVGGGEKDTPLKEEAVGLLEDDLSNLTFADTRKRERLQELAEVSRLPTTSHAEQKQTVTRKDSSESSQQAVLNQNQEVCLPTVLPSRDDSKDSHAREEIKTRQLRDLKSEENLRQGCSENRGESKSEDTPSNVTADIDASSPGMDLGIASEDLQGVKKKKSKKKPKKSSAQVVKEASLLQSVSRTFVEWITNDTQEFLTEGASSKVSDDSGSVNLAESNLTCDPLAMTSDPSVSTTEPSLPAAKPLPCMDKLKEETEQFSLKVQEFYYGRHLEVKKKEKKAKSGQEKQEEDVDRTIRLPLVDSKSQMAIRRKILSDRLNRTYSEILTPLRLSMRDMSTDLQSLIRTFNLSSTNITFKPAGWTMMSLLLLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALY3</accession>
    <name>A0A914ALY3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065035.1">
        <property type="nucleotide sequence ID" value="XM_038209107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALY3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209107.1">
        <property type="protein sequence ID" value="XP_038065035.1"/>
        <property type="gene ID" value="LOC119735408"/>
    </dbReference>
    <dbReference type="GeneID" id="119735408"/>
    <dbReference type="OMA" id="FICEANY"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038137573" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="167" mass="18438" checksum="CD22D0356ED644F6" modified="2023-02-22" version="1">MAFMRALCFVLLVGFAAACKPDCSLKCPPKCPPMWTFYNGNCYHYFGTAKTFAEAENHCKEFTQVGQGHLASVVSAEENDLLLTMWKSARGTTAGGMWIGFTDEADEGNFIWTDGSAVGFTRWRSGQPWSPAGDADCTEMKEGWDGEWNDTQCGDTNAYMCKMATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMA2</accession>
    <name>A0A914AMA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064867.1">
        <property type="nucleotide sequence ID" value="XM_038208939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208939.1">
        <property type="protein sequence ID" value="XP_038064867.1"/>
        <property type="gene ID" value="LOC119735233"/>
    </dbReference>
    <dbReference type="GeneID" id="119735233"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037158271" description="Partial AB-hydrolase lipase domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="487" mass="53689" checksum="EBCFA4ACF58F0EE3" modified="2023-02-22" version="1">MARFSVLCSVLVFLALFSRGDAWLEWLWSWNSSEAPDPDVMRNASELITSKGYPCERHFVTTADGFILGLQRIPHGRNETGVHSSTAQAINATEPSTNTTKRPVVFLQHGLLCSSTNWLTNLANQSFAYILADAGFDVWLGNVRGNVYSMGNTHLSSDSNEFWDWSWDQMAEYDLPAMVDLALEVSGQDQLYYVGHSQGSLMAFAGLSKNKELEKKIKMFFALGPVATVGHMTSPLRYLSTFLPEIEFLLNILGVRDFLPSSKITEWLAADLCTGADVWCENIVFVLCGFDRSNLNEVFVLLNCWSVCLSRCVTFFVLILSINSLIYSATNSAYRSAIAEAFSFLNLAHHCKSQTEQVSRKAREQKESLAIGPNEAAADAAKEQIELSAIGPKDASQQLVHVQIELSPIGQRNAPQDVAQDQTCPKDAAQELVHVQIEVSPIRPNDAAQNLVQDQIGSKDEAQELEGIDLSAIEPKDAAQEPAQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMX1</accession>
    <name>A0A914AMX1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064856.1">
        <property type="nucleotide sequence ID" value="XM_038208928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208928.1">
        <property type="protein sequence ID" value="XP_038064856.1"/>
        <property type="gene ID" value="LOC119735222"/>
    </dbReference>
    <dbReference type="GeneID" id="119735222"/>
    <dbReference type="OMA" id="WWEIPRA"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="144"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="226"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="52229" checksum="73684B7AD681C9EA" modified="2023-02-22" version="1">MYVDSDPRDKQLHEHEHSADDPCMPNPCQNGEQCMLQGNTYDCMCQNGATGNNCQNANANTTTINTVVVIVVVVVLIVVLVIVVVCFVKRSRRRRRGGRPSAVDRGRGQELIQKKLSNVYWIDTLQASASEFSGPAKEFPRDKLHILGQLGSGSFAVVYKAEAEGIIRRGTNTTVAVKMLKESATPNDQSDFKKELQVYAMLDRHPNVLSMLGYCTDKDPMYIILEYVPHGDLQTYLRHIRTGTEPFYLKKGEFKEKKDLTPTEILTFASQVVRGMEYLASKQCIHRDLATRNILLGKEMVCKVSDFGLAREVAEKSQYEMKSQGKIPVRWMAPESLLSNMYTSKSDVWSFGVLLWELVTLGSHPYPGMSSQKVIDEIKQGYRLPKPEHCSDDIYQIMKDCWQEKPEDRPDFAGLHTTIDDILADAAGYLEMGNLNPEDYVYLKPGQGSNSITCSLTRSATGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANL9</accession>
    <name>A0A914ANL9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein BRI3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain protein I3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with BRI3BP. Interacts with MGAT1 and IFITM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065091.1">
        <property type="nucleotide sequence ID" value="XM_038209163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209163.1">
        <property type="protein sequence ID" value="XP_038065091.1"/>
        <property type="gene ID" value="LOC119735461"/>
    </dbReference>
    <dbReference type="GeneID" id="119735461"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="111" mass="12234" checksum="A306C4BA57A8BF00" modified="2023-02-22" version="1">MEPPPAYDHTKQPAYPVPPHQSYQQQGYAPQPQPQPMQQPPMDQFTVPAQTTSQIVTVGDCPVCHIGNVRRRCGCSPLAILLAILLLPLGLFFCFWSTEKVCSHCGARFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP24</accession>
    <name>A0A914AP24_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065775.1">
        <property type="nucleotide sequence ID" value="XM_038209847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP24"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209847.1">
        <property type="protein sequence ID" value="XP_038065775.1"/>
        <property type="gene ID" value="LOC119735901"/>
    </dbReference>
    <dbReference type="GeneID" id="119735901"/>
    <dbReference type="OMA" id="EQVDETC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="122" mass="13742" checksum="82CD1847E0B4EF37" modified="2023-02-22" version="1">MSTKKEDEEDEGGEEDEGGEGDEEEEEDEEDEEDEGDEGDEEEEEEEEDEGDEENREEEGDEGGEGDEEEEEDEGGEGVRGMRGVRGMRRKRRMRGVRGEGDEEDEGDEEEEEDEGGEGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AP94</accession>
    <name>A0A914AP94_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065301.1">
        <property type="nucleotide sequence ID" value="XM_038209373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AP94"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209373.1">
        <property type="protein sequence ID" value="XP_038065301.1"/>
        <property type="gene ID" value="LOC119735607"/>
    </dbReference>
    <dbReference type="GeneID" id="119735607"/>
    <dbReference type="OrthoDB" id="10237615at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977736" evidence="3">
        <location>
            <begin position="35"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="233" mass="25498" checksum="0FF9E7FEAF42187B" modified="2023-02-22" version="1">MMVDLRVKVRICISRPSSWLWLLLVFHFILQSATLPVTTPPRTEADLICQSKLGEIFVYDEGVGICVSCRSCQCAYITGNPHCVKCVDYGILPCQTTTAQVTAQITAPVTGTPLQESTPSLQTSMQTTEETPLMAFMTTMQQNDTAETNANNVEKATWSTVVGFPLIAVMVTVVGVPSLVFGVFMWKRRPSTSGAARQQVPTQETGKREPHPSTDLTGVIPPNHEFSENESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQ28</accession>
    <name>A0A914AQ28_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L37, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065738.1">
        <property type="nucleotide sequence ID" value="XM_038209810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQ28"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209810.1">
        <property type="protein sequence ID" value="XP_038065738.1"/>
        <property type="gene ID" value="LOC119735867"/>
    </dbReference>
    <dbReference type="GeneID" id="119735867"/>
    <dbReference type="OMA" id="WERGWHD"/>
    <dbReference type="OrthoDB" id="5835618at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="430" mass="49582" checksum="3D22DA6E13CD2903" modified="2023-02-22" version="1">MALFHTTHQAATILTRCLPAVSSQLLFHRGYRPEVLKRGIEKNKQKKKPLHRVVEEMLGLEPAIEQPPRVELPNNHPQYSNRVDFGPENPHYHDDVAYLFTHDVSLQEGVKQALWLTKSKLMGNGQMPNQIQDLTTSLEIPDMDEKVEQSIRQCRQYDTVNKFISMKRYSFTTTMALIRLCSLLGPQYSDILSRAQAPNYYVSASWTRENNVIQVRGRPGMLMTSKNPLQPLAGLDEIQQTSDHTLETFYPLAPTIDLRTCYVYKDNYNFPGFHDGYPFPHAHTLFMYGEYDERQAEKINARGIMFAFANALCRAKLQYGTEEMDLPTPFVTQCVVTNGVNFSYIHVQLNTLQLDSSDGLKNMVWLDADSALYQDMYPPLLKIRRTKGNRKTDRRYIRPLVRRDPELGCRELDVDVFRKFLACYLNGAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQP8</accession>
    <name>A0A914AQP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066380.1">
        <property type="nucleotide sequence ID" value="XM_038210452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210452.1">
        <property type="protein sequence ID" value="XP_038066380.1"/>
        <property type="gene ID" value="LOC119736433"/>
    </dbReference>
    <dbReference type="GeneID" id="119736433"/>
    <dbReference type="OMA" id="AGVMACG"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000026">
        <property type="entry name" value="uncharacterized protein LOC100182860 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037892572" description="Fibronectin type III-like domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="655"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="751" mass="82639" checksum="22D303085EBF6D3F" modified="2023-02-22" version="1">MAAKYLLISLLSLLLSTNALLASSTEFPFQNFSLPWEERLADLISRLELDDIVLQLARGGAGPNGPTPPIPRLGIGPYNWNTECLRGDVQAGNATSFPQAIGIAASFSVDLANSLASATSEEVRAKYNNFTQHGIHRDHCGLSCFSPVVNIMRHPLWGRNQETYGEDPYLTGEMAKAFVNGLQGLQGPAARYLRTAAGCKHFAVYSGPEDYPSSRYTFNAGATERDLYMTYLPAFRECVKAGAYSVMCSYNSIDSIPACVDQRFLTDILRTEFGFKGYVVSERNALEYVFLKHNYTQTPLQTAVAGVKAGCNLEQADWAQNVYTNLTKAVQAGLVTEDELRQLVRPLFYTRLRLGEFDPPEMNPWGRLQASEEVESLQHQNFAVLAAVQSFVLLKNANNTLPIGRVNKIAIIGPFANSPQDLFGSYAPQTDPKFISTPWDGLRRLGRSQRLAAGCNNPICDQYNQTAVMDAVTGVDLVIACLGTGTQVENEGLDRRNMSLPGHQLELLQNAVKYAVGKPLILLLFNGGPLDIGWADNSTGVHAIMECFYPAQATGTAVHNVLINSQFPTDASPSGKLPFTWPRSLDQVPAMTNYNMTNRTYRYFTGDPLYPFGYGLSYTQFNYINITVGNTTIHPCDNLMVYVTLVNTGTSYAYETVQVYIKWHNASVTTPNIQLAAFNRFRTTPYNKVTDYLTIPARVRAVFTNALVLEPGVFTVYGGGQQPDQKRQVGSNVVNTTFTVAGPVTPLSTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQV4</accession>
    <name>A0A914AQV4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065786.1">
        <property type="nucleotide sequence ID" value="XM_038209858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209858.1">
        <property type="protein sequence ID" value="XP_038065786.1"/>
        <property type="gene ID" value="LOC119735911"/>
    </dbReference>
    <dbReference type="GeneID" id="119735911"/>
    <dbReference type="OMA" id="GRSHACC"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="152" mass="16902" checksum="20684445E111EAC9" modified="2023-02-22" version="1">MEDGRIPDASITASSVYNNDQGLFGPTRARLGNPDHDGAWCRAGTVDTDPWIQVDLGSNATITGVITQLPPGRYYWVEEFKVAFSDDGQEWTDVTDCGSSTPMKFPANFDENNHVTTTFPKAFQARFLRILPTQWKAACCMRFEVLGCTINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS44</accession>
    <name>A0A914AS44_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Laminin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066592.1">
        <property type="nucleotide sequence ID" value="XM_038210664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS44"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210664.1">
        <property type="protein sequence ID" value="XP_038066592.1"/>
        <property type="gene ID" value="LOC119736648"/>
    </dbReference>
    <dbReference type="GeneID" id="119736648"/>
    <dbReference type="OMA" id="ANTCEAP"/>
    <dbReference type="OrthoDB" id="9981301at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF440">
        <property type="entry name" value="LAMININ EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433124" description="Laminin N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="39674" checksum="7AFA956F4B73EBF9" modified="2023-02-22" version="1">MLMFLAVAFSLVARPADTQLQRQYVSSQPVNLRLLYAQDMATVAVTPEDATCGMQGSQQICSLVDPRICQNCLASDPRISHLPELILDPSNSTYWQSSPWGDAYPSPFVVNVTVSLLNKMYILEGDVTVRFRTSAPEAMVLQKSRDGGVTWTAYQFFSIDCVADFSMEETNSVSVIADVLAPSCVKPSGSDAEPGVYMIKFDLTGKLNPLIENKESFYSELEKHGPLWEFLTLTDLRLVLMRPASSLSGGASNGAKLHYGIYSIDAALSCDCNLHGRYCELDNSTSQVHCNCTHNTEGVSCERCQAGYQALPWQPGSNLPFPVGTANECQVMAVLSGSCPHNNFTVNPKHPSVVNRTAPGCSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASY4</accession>
    <name>A0A914ASY4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066589.1">
        <property type="nucleotide sequence ID" value="XM_038210661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210661.1">
        <property type="protein sequence ID" value="XP_038066589.1"/>
        <property type="gene ID" value="LOC119736646"/>
    </dbReference>
    <dbReference type="GeneID" id="119736646"/>
    <dbReference type="OMA" id="CFENISG"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="43304" checksum="3A9766AF668BC18A" modified="2023-02-22" version="1">MELPQILQPSGLKSQIVVFFTSLLIAGMAFCFGSPCTGQTRLQFYGAENCALDRSVYETTTTVSPVTCARNCHADVRCMSLNYYWPNRMCELSTTTRSQETSRFTERQGSVYFDSDEETQRFSVPSLTSALSTPMINEEAPDTITNTTPAFPTPEVEVDPIPNEPTEPPPTPTENPTIGCKRQGVNTVYPSGTGPGIQVDCELIYGKYWMVIQRRQDGSVDFYRNWTEYREGFGNLSGEYWLGNDNIRQLTESQGPWMLHIDLADWHGQHRHVRYNDFSVQGEEYTMHLGNFATRNDFDIENSLAHENGRSFSTWDHDNDGLDSRTCAVDNHGGWWYDGCVLANLNGFYFQEETVDDHAITWFSWRGLYSLKQCSMKICLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT33</accession>
    <name>A0A914AT33_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_038066927.1">
        <property type="nucleotide sequence ID" value="XM_038210999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AT33"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210999.1">
        <property type="protein sequence ID" value="XP_038066927.1"/>
        <property type="gene ID" value="LOC119736955"/>
    </dbReference>
    <dbReference type="GeneID" id="119736955"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="254" mass="28737" checksum="498159C26BBE312C" modified="2023-02-22" version="1">MENHKKTILLFDVDGTLTASRQIITAEIKEFISSVCEKFSCGLVGGSDCVKITEQMGGQESLDRMGFIYVFSENGLVACKRGKTIGLMNLVEHMGEEKLQALINFALGYFASLKLPAKRGTFVEFRKGMINFCPVGRSCSQAERQQFSDLDQKEHIREEMVKHLREKFDADGWEFSIGGQISIDAFPKGWDKRYCLQYLEKDFDTIHFFGDRVLKGGNDHEIYSDPRTIGHQVMNPADTKKQVLELLSENGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AT71</accession>
    <name>A0A914AT71_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066967.1">
        <property type="nucleotide sequence ID" value="XM_038211039.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038211039.1">
        <property type="protein sequence ID" value="XP_038066967.1"/>
        <property type="gene ID" value="LOC119736993"/>
    </dbReference>
    <dbReference type="GeneID" id="119736993"/>
    <dbReference type="OMA" id="LAQDYWI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008281">
        <property type="term" value="F:sulfonylurea receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000388">
        <property type="entry name" value="ABCC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01092">
        <property type="entry name" value="SULFNYLUREAR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1250"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="334"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="713"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1344"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="946"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1581" mass="177697" checksum="55B05C7643F13877" modified="2023-02-22" version="1">MDVVKSTSMVEASGKFMDFLKGVPMAASGIAEFNWYCGVNNTENLDHFTHDLNHTLYNACFVDLVYTLPHLIFILLGILVLFVLRCCTSIRRRKYTYLIPYPGHYLRWVLYIIFVLLTACELGEGLLTDLGVYHGTPTRPHLYIPAILCLTAAILSVIYYNQMELWSRPHMSWLLLVYWLSALGAEIVRFLNLDHDPLVDFALMRSDLNIAAIVVYALLVLLELNVIRTKVFKCCTTEEPFPADLLRPDMRFMQEYSNFLSVIMYSWLGWLYVEGYDHSLEYEDLGCLSDVHTTRYQSDRFNRALKKEQERARAKNTSLSMFRVYLRAYGWEMFLAFLCRLLGDTAAFVPPFAVAGVVNYVMQIGEPHEYHAKYLSAEDFITNGFVLVVILFLAATARGIALQGHYQIVIIASAHVQIALQAAVYDKSLRLASYTMTGGSLTKGQITNHMSVDAINVLECFQILFYLFSVPYLCIGYLVILYYQLGLAALIGFFIVATIIPLSSLIAKKTGHFQKNALEKADERLKRTNELLQGIKLIKLYGWEDMFYSTISKVRGLEIRALLKQTFAKIFMLTLSNSCPLLVTLVSYSLYTALTGKLLTPAVAFGSLAAFNQLFFPLMVLPYTLITTINAVVSTRRLKAFFLAPEIERQREPEMNGYNEVGVRYQCNKHSKNQPEDKQRLLDQSYDKLHFGTFTPHPSLSDGLTDLPRDVACRINGSFAWEEGSSLPTLANINLDIPMGKLTMIVGQVGSGKSSLLSALLGEMITASGGVQWNQNCGSIAYGAQKPWLLNATLKENILFGNGFDKKRYKKVITACSLQPDIDILPAGDQTEIGEKGINLSGGQKQRVSVARAMYSENDVVILDDPLSALDIHVGGHLFKKGIEGFLMKKSKRTVVLVTHQIKYAEKADIIVYMKDGSIENQGNLEEIREENPELVASWTMAGSSENLASDSETSGHESASTTEERAQLTRQVSNMKPADGVNELKDAKGRLVQDEERVKGSVSWRVYLTYIKAIGIVAFTFLLMFAIFQQALFIGTNYWLSYWSEAGRNIANKTKEEQDELLQYYLNGYAGLSVSSVFAGALTIAIVFTFTLLASRRLHNQMLKTVMHAPMRFFDTTPIGRIMNRFSSDVKIIDQILGNTFNSFQKYWLTCIGAIIVNIAVSWYFAVALIPFVILYLLIMKYFIKTSRELQRLTNISKSPVFAHFSETLEGLSTIRAYRQQEHFRDDLIRKMELNNVMFIYMNTSNRWLGARLEVIGGFIVLIAGLSTVISAMDGVLLPSLVGLAIAYALNASNQLNWMIRSSANMEMQLNSIERVDYYKNIDTEKYEGTVSAPANWPSNGVITFEDVSARYDTELDPVLRSISIHIMPGEKIGICGRTGSGKSSLLLALFRIIQTFQGSVFVDNIDIASLPLLQLRSRLAIIPQDPVLFTGTIRFNLDARNEHDDRALWEALEIAQLRETVSELDLGLNAMVTEGGENFSVGQRQLFCLARAFLRKTRILVMDEATASIDLETDKILQQVVATAFEDRTVLTIAHRVQTILDSDRILVLSEGRVAEFDTPENLLAKEDSMFASMVKAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AUH5</accession>
    <name>A0A914AUH5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_038067412.1">
        <property type="nucleotide sequence ID" value="XM_038211484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AUH5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211484.1">
        <property type="protein sequence ID" value="XP_038067412.1"/>
        <property type="gene ID" value="LOC119737275"/>
    </dbReference>
    <dbReference type="GeneID" id="119737275"/>
    <dbReference type="OMA" id="CSHEGAS"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="28745" checksum="88DE3FB1834DB69F" modified="2023-02-22" version="1">MGQKVSSSPRVRMNYGGPISHQVVHDPSYADSGLGEQDNSHRHSPSVHPHLAMGSSTSQANGHQSYHQRGSYPSSTMTGSTSYAAPVLTSQQHSRSRARSLGNCSHEGASSSGSRSLNIPGMMMDLNIGQDSDDSSPEDNVSSLPMTRSRGRTFPFHAQSLPAHLFTSSLLQNVHHVQGIKCPVCSKSVPSDDVECHLVICLTKPRIVYNEDVLSVDAGECVICLDDMQQGDTIARLPCLCIYHKSCIDMWFERNRSCPEHPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYI6</accession>
    <name>A0A914AYI6_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069215.1">
        <property type="nucleotide sequence ID" value="XM_038213287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYI6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213287.1">
        <property type="protein sequence ID" value="XP_038069215.1"/>
        <property type="gene ID" value="LOC119738401"/>
    </dbReference>
    <dbReference type="GeneID" id="119738401"/>
    <dbReference type="OMA" id="HMEQQFK"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="20572" checksum="045E87A867C357E1" modified="2023-02-22" version="1">MERLHTHVWFTGKSLINVLTELPNYGIGRLVTRRRWTMMYPESEPCYVKITRVKVDCTRPELDRGQVWGELTFRGYKREGLVVEVGAWWKREWELIRKADEEDFCKFTPKPEDFHVAPSHARMPPLLEAMVLKQQADKGIKVDADDPPLLELEIRRTYRHKAYQLASQKIIGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYQ9</accession>
    <name>A0A914AYQ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein Lines</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068837.1">
        <property type="nucleotide sequence ID" value="XM_038212909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYQ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212909.1">
        <property type="protein sequence ID" value="XP_038068837.1"/>
        <property type="gene ID" value="LOC119738160"/>
    </dbReference>
    <dbReference type="GeneID" id="119738160"/>
    <dbReference type="OMA" id="KCESSHT"/>
    <dbReference type="OrthoDB" id="8251209at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029415">
        <property type="entry name" value="Lines_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032794">
        <property type="entry name" value="LINES_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024875">
        <property type="entry name" value="Protein_Lines"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057:SF1">
        <property type="entry name" value="PROTEIN LINES HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057">
        <property type="entry name" value="WINS1, 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14695">
        <property type="entry name" value="LINES_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14694">
        <property type="entry name" value="LINES_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Lines N-terminal" evidence="2">
        <location>
            <begin position="332"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Protein Lines C-terminal" evidence="3">
        <location>
            <begin position="792"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="92968" checksum="BE2609A12D83C4B4" modified="2023-02-22" version="1">MAQLDAAVIKLNQHLLDNTCLCDMDEASELRGMSALKSWLRGEDNVQDVLEGLLEDTLENNMKKPDRMLVGLTISKHLFEATHCAHVLHLQRQMVDSGSLLEDLGTLMSSEDRLTAFMTCQMAKAVLSSPAIDKEKAVLFLHQHLLGIGTVIRHAGHHHQTLGLVNSPSQCRQNQPNYHGQKQRNQVSPVEVSKGQMDPDQVNLNPDDSSQVCKGLVGSGQMSAQSYLGQESTGHSHATRDLGNVSKIQSHLDRSTTHLGQVNHAVFTLDLCRLLLKKICHEGSRQVKSENTGTSQGSQQPSCIQAAHSIADTGFGRLQDCQKELRHLLCRDLPCILQDFALPLPADEPHRVNMDTKDTILILASLLDLVHALLKHRHVEQHWQGFTSKLGSSLMHLFKDYCHDVIILKRLLDIFVLFTDYSPVTSCIPHSGQSHSSHPLVATLDDALITTAAGFVSMVAKGSFLEHIPYRSGPIGFGGGHFHPSSSNHEDKSGDHPLLRKLYQATLCAVKTLLNCHKSKTIYDESDVGGCLRNLWGYVCCKLNHIIPTDAHIWLVFELFSEQDDGLVWVMHCSLDLYKASQSLHPPCSLLVGQLNPHRIFCRFLDTVAYDPSVLLDLLISSETPFLEYLVCYLHTVLRDWDSFCSSLQEVASMDSKSHSQNSADVASIKPPVDEKPYFAKCESSHTHQEREEGVETSIKTKRRKTQVDGDTHQETARPKDELEYTSSSQATSSPAGAGNFSCNSCKRTDAEDIKRTPAQDSSEALSTSPNDQTLEMLCSQTNIVSQPLDDVMTTLIRLRFSIARISGSNLFPYPITPLLRLLERVEGMYEGDISEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ39</accession>
    <name>A0A914AZ39_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partner and localiser of BRCA2 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068789.1">
        <property type="nucleotide sequence ID" value="XM_038212861.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212861.1">
        <property type="protein sequence ID" value="XP_038068789.1"/>
        <property type="gene ID" value="LOC119738120"/>
    </dbReference>
    <dbReference type="GeneID" id="119738120"/>
    <dbReference type="OMA" id="TEHTHAR"/>
    <dbReference type="OrthoDB" id="9936560at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042417">
        <property type="entry name" value="PALB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031920">
        <property type="entry name" value="PALB2_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14662">
        <property type="entry name" value="PARTNER AND LOCALIZER OF BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14662:SF2">
        <property type="entry name" value="PARTNER AND LOCALIZER OF BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16756">
        <property type="entry name" value="PALB2_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partner and localiser of BRCA2 WD40" evidence="3">
        <location>
            <begin position="964"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1295" mass="140653" checksum="CE5F5BCB4570E45E" modified="2023-02-22" version="1">MADSSTANSKLELRQKLENMKKAYAQTLRKVQKSEKAKRTRSHVQRVIAEQSHVISNDASPSCTHRLSRRICGDGDVTGRPEKLSSSETGTASEERVINVAVNKDEGSKSTMATKRMQRKRRSVSFSIPKENASTRTPIVDARVGDTDSHLGSSEVQDKQQSKKIAAEISQNEHVVRASSSSVLSDGKARDMSRLDEKVTLVVPESQFTEPLDESLSERNCTPATTPRDLPVLGGFQGNVIPSGNGNLNSPQSDIHLPKSASLGPNKMRPSDQSHPANAQSLSGDNSKTKDEQKRSPNSCQSSSKVRTRRANGNSRRRSRVPRELTAADISFKEVVECQSTEEGSHTWIEGMMYPAEYYVRRTRSMTSSQCSQSQSNLDVADSQRYWDKDPRMRAKGKGSSTGISGSYKDSMSQGTGTLPSGVNSLTEASESVSRTDSDSMKSQLSQSLLKAYPGQSAQKCTDKNVSGSVKPTKTSRNQRLQRKRGATSVLWTDTKAKSSIQTDSVVKSVGEFPAGQLLLTVANVKLPQTEFALPEEDYGALKMVKLQRGPSLDISSRTLDSKGQLEGIPDHLVESQSTCLVPVVKDVAKTDHQGVIQQENSDSESCSALPLAKALNCLETMEAPIHFSSPGSMDSGKDEATVPSKMTASSKEALQSGMSQCKEIATSRNANPAKDGSSASRYKNVGSDIVGRQTAKPQGRGVLESQLSPTQNKEDRGMAFPDPGCTPGWSPTCSPGVGHEVTGPGDLPLSSRDKTGSRRCQNEDELKGLMSKENVNIKPKTASIDDVSKCNNSPLSGPKNCGSHLPNTSPPQSSKVNNQCSSCGNVRQSSLSASPTLPGPSCQDDTSKSTSRLQTVRRNPAAEPSTVDVNAVDGNVTPPNAIQRVPVDPRGNIKQISPFAGVATGTPPGRAEEPMSMSQCVVQISGEEDDETSDESGRGSRQELALAGCLQHDLPWEALPTVRDVTGSWMHMNGQDVSLLAILHQHTLVIWWTSSDTQEWQILKSWVLPEEEEFLCVRFMPCSRHDVMSLVVAGIFGTCGVRMLNYDTVTEEMQQMDVNLSHSCESPVQYLLCVTDEEEFAVAVKDDTSSALFLVNACIESRNVQTVKLWTGKDTYLTSLLQVEGTNGMLMATTAHNDLMLWNCKTGELIKDIPMKSVDGRSRASCLKAVAESGLLFLVIIFHDDVGEQEVHCSQPIGATIVFNPLTDKMATLVEYQPSTEHTHARLADAVIHKHSLLAKLSDGSLHQWDIFSGNLMNYSSLQPANHSLRSAHLCRSEVVLLGTDQCQQVYDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B360</accession>
    <name>A0A914B360_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070457.1">
        <property type="nucleotide sequence ID" value="XM_038214529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B360"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214529.1">
        <property type="protein sequence ID" value="XP_038070457.1"/>
        <property type="gene ID" value="LOC119739550"/>
    </dbReference>
    <dbReference type="GeneID" id="119739550"/>
    <dbReference type="OMA" id="HICRMQC"/>
    <dbReference type="OrthoDB" id="9419183at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF420">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037460221" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="91"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="366" mass="41093" checksum="048382BA54302305" modified="2023-02-22" version="1">MMLCHFICLNAFLALQSRALLVVSGCVAVSSQGSDIVIMADANNVTAMEQLVNSTSTDWPETYPDSDTDWSTLRIVSVTLNVPTTILILTLNPLCLCVIWRVPDTQSTNKVFMASLIAADFFYGLLVCIPVTLSLITGYWPFGSFLCATFSVVGEYMFGLICFLSLLQLTVDRYLAVAWCLHYSRLMTLRRAKTITLLNWILALIVSFCGHVEFFHKHQTIDSTECDLAARLVLHYILVVLIIIGLIIILMLYLHILVIARRQARRIAQENQPIPGPARKNTKSFSTVIIISAVVFVGWMPSLIIELVDTVNVPSAVIYTTDFLFFSTNWIDAVVFCLRNKEFRETLRKMAATGCKVFRKCDCIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B411</accession>
    <name>A0A914B411_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070235.1">
        <property type="nucleotide sequence ID" value="XM_038214307.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070236.1">
        <property type="nucleotide sequence ID" value="XM_038214308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B411"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214307.1">
        <property type="protein sequence ID" value="XP_038070235.1"/>
        <property type="gene ID" value="LOC119739380"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214308.1">
        <property type="protein sequence ID" value="XP_038070236.1"/>
        <property type="gene ID" value="LOC119739380"/>
    </dbReference>
    <dbReference type="GeneID" id="119739380"/>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008489">
        <property type="term" value="F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF38">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="512"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="619"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="747" mass="80720" checksum="B2877B617840A64F" modified="2023-02-22" version="1">MDMKSSSSIDLPDIFSPDDSVSSHGRPGGRVFGGAGRSHPSSVKSAGPLRNLSLQTFFRLMALTVVCTTTFALYYINSGVIRNTTPTATTDRGDIARQVLKNPAATNKPTDRIAPPLNHPSGVQNTSTAKLTSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGVQNISPVNIPSGVQNISPAKLPSGAPYISPAKIPSGVQNISPAKLPSGVQNTYPGGVQNASPAKIPTGVQNTSPAKLPSGVQNTYPGGVQNASPAKIPTGVQNTSPAKYPSGVQNISPAKLPSGGQNTSPANPSGSAKATQLLGDSRKTCPELKKIPNLSGAAKELHLEETPMTTVESQVFGNMRDKILHLVEEGNRQMRAPSLQTPSTGGTGSYDRLLGSLIPLEAMLDNYSYLPGGHWRPMHCTPRWKVAIIIPYRHREYHLPILIRRLVPMLQKQLLQFAIYSVNQENNMPFNRAMLMNVGFLESLKFSNWDCFVLHDVDHVPLSDLNDYGCTNMPKRMLSGSDRWNYRIPYHNFFGAVTGMTRENIRTINGFPNVYWGWGGEDDEIFERVRARNLNVYRTTGPENYYKVITHHHMSSPAMKERFDLLRSFRSRYQQDGLNNIRYTRPLIELHTLYTNISVNIQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4S4</accession>
    <name>A0A914B4S4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070486.1">
        <property type="nucleotide sequence ID" value="XM_038214558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4S4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214558.1">
        <property type="protein sequence ID" value="XP_038070486.1"/>
        <property type="gene ID" value="LOC119739578"/>
    </dbReference>
    <dbReference type="GeneID" id="119739578"/>
    <dbReference type="OMA" id="PILCEME"/>
    <dbReference type="OrthoDB" id="10256139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026224">
        <property type="entry name" value="DPCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921:SF1">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
        <property type="entry name" value="DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="213" mass="24233" checksum="635BC7A9D68A05D3" modified="2023-02-22" version="1">MASSMNVAKTLSSVESWLQELKSAKKTALVQDACKKVHFIFTSGTEMVEEYDLKSNELLVRKWKTKTTLGGAGKWEFEIGEQLCLAASLEVEPLRESSLNPIFTRKDTKQSFQWRIRNLPYPMGVYSVTVDNDNRCCIVRTSNKKYYKKFSIPDMDRAGLVLDQAAVSIAHANNTLIIMYKKPQEILKMERLVQQEIQKIKASKDGDVECNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B529</accession>
    <name>A0A914B529_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aryl hydrocarbon receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071178.1">
        <property type="nucleotide sequence ID" value="XM_038215250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B529"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215250.1">
        <property type="protein sequence ID" value="XP_038071178.1"/>
        <property type="gene ID" value="LOC119740049"/>
    </dbReference>
    <dbReference type="GeneID" id="119740049"/>
    <dbReference type="OMA" id="AMYTCHK"/>
    <dbReference type="OrthoDB" id="6099906at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="107175" checksum="4B99756DA360E94F" modified="2023-02-22" version="1">MLSQQCGGDDYGIHGQPPHSTGTLPGSSAGMSPYARPHRQQQQQQQPGLRSTGSSKIDPSFKSKRYRDKLREQIKALENLLPIDKATLHRKLDSQTVFRLVISYFRTKVFFQVAVEKLAFRFGGARVGKLARLPNRDTFSLPFFLILDVARPVLERANYGTLEVEVAGSAGDKRVAYICHSLLKRVHFFHFGTVAGFSSVTPDEAEVTGQQTPASRDPHKSHPAKRESLLTEAVCKDFCDRSEVQLALEALDGFLLVVTSDGTILYSTENISSHLGFHQVDLVHRCLYGIIHPDDHPELKAVLEQTLASPGCQSRVQMETAYGVRCGIEEPGTSDTGKVSFLCRMKCFNGTSTGFVKMHCCGTMHSFPGAVKSGRTSCQVLFLAFRPITSLAQDTDIEFKQNVFWSKHEMDLTFKLLDTRACDVLGFDPSELEGRSLYDMIHPQDLAAMYTCHKTLVDTEEVHTLYFRLMTKDSSWVWLHTRAKVIVKNSRKHSIVLTHCPVREMDSSYLHHEAKARARYGLDEYLKMKHMNHSGTDGETSSSTPSTTPQPDCNQTKRRWTSNDTYVVASQSPYKLKDDYSASLHSPHGACPSSYHQSSDRHSPVYPSTYAPHRYQKAAQGVQSPPEKASNEREPPPMNVNFYDYAHASEDFIQGPPLYPSHPQPHPALSMYQMVAHLPPEMYDADSYRKHALMFMESHPHLAGPGMMSSYHHHHMAQYQLPLTPQTSPQSFYPQGHFPTHYPEHVPTVHPAGSETLSPPPSPNRNFKPACMYSSVGSGDGCDKGPEPIFSADCCKAEHYTSLFVNGAVQVKLLDGATYPRTQYTNGYSHEYPHGDQYSSDSSCLYGNHYETDIELKPFQRMGALPHDKLDASTCNLVSYTDAPVDSSVPIHGYHSNRVAHDRERCLPCPMANTRNGCLAPKLPPVNDVRILSPASSLPPIGSFLDFLNEDGGMAPVEESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B550</accession>
    <name>A0A914B550_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Limbin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070611.1">
        <property type="nucleotide sequence ID" value="XM_038214683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070612.1">
        <property type="nucleotide sequence ID" value="XM_038214684.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214683.1">
        <property type="protein sequence ID" value="XP_038070611.1"/>
        <property type="gene ID" value="LOC119739670"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214684.1">
        <property type="protein sequence ID" value="XP_038070612.1"/>
        <property type="gene ID" value="LOC119739670"/>
    </dbReference>
    <dbReference type="GeneID" id="119739670"/>
    <dbReference type="OMA" id="ISIIICH"/>
    <dbReference type="OrthoDB" id="8852462at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022076">
        <property type="entry name" value="Limbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026501">
        <property type="entry name" value="Limbin/EVC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795:SF14">
        <property type="entry name" value="LIMBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795">
        <property type="entry name" value="LIMBIN/ELLIS-VAN CREVELD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12297">
        <property type="entry name" value="EVC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038275750" description="Limbin" evidence="13">
        <location>
            <begin position="31"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1426"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="975"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1483"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1586" mass="181874" checksum="CB05DF67E32CCA44" modified="2023-02-22" version="1">MPFLLIKMALQDLHFIFIICCLACLKGCHAQLVDVALQVDSPTSNPMIGGFPSLHLSDRLTINIGLQFGSSGEQAKLSLQVPEEFAQVTSDNLTISYGSNLQDAQETVQISRMHLNVTFGEVQVINATLGNNSLENVIDLRYVLYIQDFKNVGDLFNMTLSVDYGMNYEDSFSASRIFSYAGPEVDIERLQNSDGQPFIFDREMQVSASIRLPPGLWNMSDTQVILDFLSDDVSFINLDVFSCLAASDSPNITFSDPASQNVTTFTNASSPIAVVTIQNATVNQGNARRKRSVTAGNQASASLVWNLFDVANIGDSVETVYFTVRSVIGQTAEMVDGVGMTYSFTMNINQENVPLNNDILVVSEPDLVLDKTMTVLNEAVNEDLDYSLNYLSFTTTLSHSSQSSAPAYGVVLTDQVQGFVLEYFNGLVPVVGTAGFDVTAQDLVYRVDELMLGDTLTISYKAYFDDDTVTNKIDMPLMHVATATWQSMPTQEITPEYPGRSYSPAVQPETCVTPIEIQEQSLVYDHGLAAIMFFVALLVGCIIVALICLICIKFCRKGPYATVQPAGKYGGGSRGQGLVMNTRGGARSGLSNLKEFCMIAIDDSIVMVLALRDKTRKLLEFDNLDIWWTITIDIQLEQQRLDAMVDSNVNLINKWATEGAIPRRISDKSNKKFQRKVKDLNKTLEDEYKEECRELIKELSVQNKLKLAELQRKHKVEYNDTVTQTKRMTEEERKEILLLLRQQHDAEKNEVMQLLKMHQDERQEKARKEIAIRKRLAIKSLQQEHLDEIILQSKLDEDAAMKLLREHRSNQQDLETAMDDELSRQRMLLEEKLAKRRALAQYNESLGDHNKQMLNTMVTQTLSVIDELEKDDKLTEQEVERYTQRLRQEFLAAKGAYDKEKTKQEEGLHKRLSELKRRKLEERAREHKQQLDQFEKDQRTKLENNNLDPSQHTEAKMDLLASQRTEMHELEISLDDDAGKQLEELNKNMAEETKEKLTRSKEGFFKDLMSHGMTERMKNEILDQHQRDMESLAEEHEEQRLKQERLLKKRLAKHRQEWIKRKQEEKQEQEMIRDHEEKVVGRILASQLAISEEDRQRILDEHEKQQVALDSSLALQKLKQRRLLEERVAKRRARQMEKLEKKHNQETQRQARKRQLADSDEGSDEETQQELMKKQAEEKLTLLSGNNDEDIEDELEAVRVEMMEAKVGALKEQEERLGALVAKLQLERSREIATIEEQQKALWQLKMNMLDDMTETGIIRNADCKKVIENHQKEAKNLENKLKAQREKQEKEFKRRLRDKLADREQLFVSKQEEEIQHLAENVKNKTSARLKRVALKHKHLMEMEEFRRNLEIEVNQALEDLRRKFEVERLKQMQEQELQFISGLVKHGKFSPSELRNILYLLFPGKTEKELEPLLRKMFNKEEGEELRENEGEGDSVANGNVRGSFDKKGKAAKSGSSLEDKIKLSILGNTGSSAVSTPSRERRKPNKLLKKLKKNKQNKKLAPITTGAQKFEDPDDHSQRSSFQGDALPQIGMLRPEPVGRTATPSDDEYIDRRVQMDTDSEEDERRPLKKKGGGKFGRSEYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B5H8</accession>
    <name>A0A914B5H8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071070.1">
        <property type="nucleotide sequence ID" value="XM_038215142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038071071.1">
        <property type="nucleotide sequence ID" value="XM_038215143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B5H8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215142.1">
        <property type="protein sequence ID" value="XP_038071070.1"/>
        <property type="gene ID" value="LOC119739975"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038215143.1">
        <property type="protein sequence ID" value="XP_038071071.1"/>
        <property type="gene ID" value="LOC119739975"/>
    </dbReference>
    <dbReference type="GeneID" id="119739975"/>
    <dbReference type="OMA" id="EWYVNIS"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17389">
        <property type="entry name" value="MFS_MFSD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="478" mass="52256" checksum="D51D7B1CACD9E7A6" modified="2023-02-22" version="1">MVEENSHQHSANGSDQSNNANYKFTPRQLDAQKRREDNENHRMISMVFLSLLIDLLAFTMILPLLPSLLDYYAQHDQGGLLPVLRSRIDSFRDLLGIPDTHKYNSVLFGGVIGSLFSFLQFIASPVIGAASDVYGRRPLMLLTMTGITISYCIWAVSHNFTLFVIARIIGGISKGNVSLSTTIVTDVSTATTRGKGMALIGIAFSLGFIMGPMIGAYFAMSSGGKGEALYFKPALFAITLAVADIIFIFLFFKETLPTNKRAGSLGSSFKDACDLISPLSLFLFSAVKKLKPSELQMLRLLGVCYFLYLFLFSGLEFTLTFLVHRRFQYTSMQQGKMFVFIGAFMALVQGGCVRRIRPGKEKRVAVIGIVVLIPSFIIIGYAQSIALLYIGLALFSFAAGTVVSCMTTVVSAYGTADQKGTIMGIFRSLGALARALGPIFASVWFWSMGPTICYAMGGVLLILPLIGLSRVVPLKLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B660</accession>
    <name>A0A914B660_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071439.1">
        <property type="nucleotide sequence ID" value="XM_038215511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B660"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215511.1">
        <property type="protein sequence ID" value="XP_038071439.1"/>
        <property type="gene ID" value="LOC119740255"/>
    </dbReference>
    <dbReference type="GeneID" id="119740255"/>
    <dbReference type="OMA" id="THAKIPY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF628">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE MER-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="133"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="441" mass="50524" checksum="E5BD8058E6C6CD6C" modified="2023-02-22" version="1">MSSEEETTNMTAGLPTATAMDTVAMTTAEPTTNGSFHVPFLWIIALSSVLGGLVVLLCIVACCWQLWKCYSKHFPKGNLRIPRPQFISEEDLTKSDFTISPQIFWEELKLDELALDDDMKKKMRMFLIPRNKLSIHKLIGEGQYAQVHFATLVSPSFSCEQKVAVKIMKEHWTDQARHLIEEGMLTVDLLHPNILTIIGISLEFVNSKQIRPLVVMPFLENGDLNSFLKNVRLANNQELSMRWRVDLMAQIASGMEFIASKNIVHRDLATRNCMLDDNYTVKVADFGLARQMHDAEFYKMKIRQSISCSLPVKWVAMEGLNDSIFTTMSDVWSFGVTMWEIFTHAKIPYPGLENYKVLRHLESGHRLYQPDGCPENLYKLMYSCWRKDPCMRPTFGYLREKLEALKVTLSTAEDTWSATIVRKNHGANIRQANALYHNAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B687</accession>
    <name>A0A914B687_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070977.1">
        <property type="nucleotide sequence ID" value="XM_038215049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B687"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215049.1">
        <property type="protein sequence ID" value="XP_038070977.1"/>
        <property type="gene ID" value="LOC119739914"/>
    </dbReference>
    <dbReference type="GeneID" id="119739914"/>
    <dbReference type="OMA" id="ALICKTH"/>
    <dbReference type="OrthoDB" id="9888774at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="342" mass="37081" checksum="B822B0D83E69DD37" modified="2023-02-22" version="1">MPTQAAPAIRLTMSDHSSTTTTLPVPQRPPTVTLSTDHESCSPTHPKTKRNLLSTLKNSPSMLRRRMKPPHLNSTRNSWDNPDSTSSSSSPVTSGSSFTAKEFHVKYQGRVRVTTLQVSEAVNAVKKLAPELTATHSPASSTEDLLNVSPSTSLSSLASPTTTLPRASSPSSPAMPKSPRSAKSPKSLNKSCCLSISKQCVCIDDEERLVNETIPIATVAYCATDLRYPRAVSLICKTHSSVLMCHVFICTSREKSEKIVAFIGKAFESAWQDFKSVHDPATHGGLGQNLTNNNYEYFIRGRSRSQDITGTGRGGSPGNTTPDRHSAYEIRNDDFSSSPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BB09</accession>
    <name>A0A914BB09_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073388.1">
        <property type="nucleotide sequence ID" value="XM_038217460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BB09"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217460.1">
        <property type="protein sequence ID" value="XP_038073388.1"/>
        <property type="gene ID" value="LOC119741631"/>
    </dbReference>
    <dbReference type="GeneID" id="119741631"/>
    <dbReference type="OrthoDB" id="10043139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="357" mass="40794" checksum="D69E9C775389DE33" modified="2023-02-22" version="1">MIAEAAHYYTANFPNISSSSEYHDIGKKMHQEFPAIAREGEHAWSFFTKCLSQRIRHMRWASKKKTVPPKPAEVQGEKRGREDTNDQPRKSVRGAQLHISGHKSCTDAEYEEHLKELASQWDKGETRNVKHIKLLLSETFRRNEQWIRTLPDSQVHPILEKIPCYEDGAMVMHDFQLLLGETKFQAIQDNIIVFMDAVEKIMESKTEEAEPERMIPIISYVEKATAFEKGKGRKTRSIITMKEDIPDGDIKKELHTPRNEPPKLVIFTSNNKLQASFVVADGVSIMSEKGSTATAAILLLIGVYYLFDLEYPKTYSQLLGTLQNHVVKGVPYDGQKSAKFRMFQTALQRKLKAVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBD7</accession>
    <name>A0A914BBD7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038073155.1">
        <property type="nucleotide sequence ID" value="XM_038217227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217227.1">
        <property type="protein sequence ID" value="XP_038073155.1"/>
        <property type="gene ID" value="LOC119741469"/>
    </dbReference>
    <dbReference type="GeneID" id="119741469"/>
    <dbReference type="OMA" id="EPCHIRV"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="454" mass="49820" checksum="20EB0ECABE5430F1" modified="2023-02-22" version="1">MEFSAGMPPKDLFVNRQHHHAAGAESAGKNPAARRPSPSNYSIDFILGTPSPSPPARTANTAEPCHIRVPVYNTTSTTGRGWDFAGCSPEGRDASARYQPSRCPEREQTPECTVSSDLSRNFQHLPSTDNFPGSDQYSPDPEPARSVPCEHGDEVSSSPEPTSPPSSSSGREDELDGEDDATHPHNQHHRGGGGDPKTARKIRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLELSEARVQVWFQNRRAKWRKMEKVQGRESPSGFFGSNYPVDFVGSHGMDSAIPTERIPAWAMHNGNPTAGVSPGLLAQVPVGLPQHPGLGAMVGGYPLFGHHFGHYVHPPHQQQHGQQHHHHQAAASYWLARQAAFPAIASPWHLPSLRIPSLRASEQSELPTSVSPPAKKSTSLANINDFPSDSHALLKKQSIEALRSKARNHSLASDELPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBE1</accession>
    <name>A0A914BBE1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072752.1">
        <property type="nucleotide sequence ID" value="XM_038216824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBE1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216824.1">
        <property type="protein sequence ID" value="XP_038072752.1"/>
        <property type="gene ID" value="LOC119741133"/>
    </dbReference>
    <dbReference type="GeneID" id="119741133"/>
    <dbReference type="OMA" id="VRTTHCL"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="293" mass="32460" checksum="6262E66D74C030EE" modified="2023-02-22" version="1">MAPQTVLITGCSSGIGLATALVLAKDELSRFKVYATMRNLKSKSNLEKEAGDTLNKTLFIRELDVTKDPTIKSVVDGILGESGRIDVLINNAGYMSLDAIDQRSLEWCQAMMDTNYWGVVRTTNAVLPAMKKQMSGRIINVSSMAGVRAVPFYATYSAAKFAVEGFSESIAPVLRDGYNIRVSIVEPGPVKTELFNKVLGTPFEEQAKDFDPVLREVFLTNVKRMMTSAMLSVTQSADEIAKLHMDIILSEKPHLRYQTTENLTKAAAEKLRDPTTDFLLEMLEQAQDRYSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDG4</accession>
    <name>A0A914BDG4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038073472.1">
        <property type="nucleotide sequence ID" value="XM_038217544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217544.1">
        <property type="protein sequence ID" value="XP_038073472.1"/>
        <property type="gene ID" value="LOC119741692"/>
    </dbReference>
    <dbReference type="GeneID" id="119741692"/>
    <dbReference type="OrthoDB" id="10209208at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037409829" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="366" mass="40104" checksum="84499F2477457289" modified="2023-02-22" version="1">MEMFLCSLFLTSALLVCVLPSAHLAVIIDGSDDDEWSSLVYRVRGLRSTSESDAQPATIPTTLRPLNPSVPEGGQIRLECTGVTPDCEYKSLLYKAEGNSKMGDVRPVQANNPTSSHNCSCNAGGRFNRCSSSTIFVMTATLQAAGTYGCVVLPNGQQQLTPEINRGGEQGYRSHETNVTVCEEPDLSLNKYSNGNFTTVNASDNCHFEGELSWRINGHRVPQESASPAPPAGLSPPAAVHRDNDLLAISKCDRWATRTPCTVTAEFTYISARRLKVAHISTDIHDCCVDLPSTVVPTKPLLTQRPQGLLTTIMAPTWQEKWNLKKKVLELKEELLPLQIKFFKKWSRNSPKNMPAQVIAEAASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BDH2</accession>
    <name>A0A914BDH2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074046.1">
        <property type="nucleotide sequence ID" value="XM_038218118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BDH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218118.1">
        <property type="protein sequence ID" value="XP_038074046.1"/>
        <property type="gene ID" value="LOC119742093"/>
    </dbReference>
    <dbReference type="GeneID" id="119742093"/>
    <dbReference type="OrthoDB" id="6610952at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="321" mass="36568" checksum="1FD6E7FDD7D30823" modified="2023-02-22" version="1">MAESYWRTVTLCHAGQEYSVTLDGPSAARLLSGDVEFAERVLENVKKTQGETDVSATLPTETVSATLPTETDVSATLPTETESSSTNEVASKYVWTGNKSEAGRKQDRAATFQLLDIVGSDKYRQMFRDDKTRKASIWKQVVVEMKNAGIKLDDDNKTAAHKCDQKYRNLERQYKDFVQYMNTTGKGKKSKPEYYEEMAALWGDKHTVRPVALVDTILPQVVTAPEEANMPESVRPKPSVAKKRKSKSSEIVEILGKMQKEDHERQTKVIETVEKMSEAINQRHQQQLQEDRAQFQEYVKMHNEKMEMQRRLIEALTSKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEA7</accession>
    <name>A0A914BEA7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038074409.1">
        <property type="nucleotide sequence ID" value="XM_038218481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218481.1">
        <property type="protein sequence ID" value="XP_038074409.1"/>
        <property type="gene ID" value="LOC119742522"/>
    </dbReference>
    <dbReference type="GeneID" id="119742522"/>
    <dbReference type="CTD" id="9961"/>
    <dbReference type="OMA" id="VTYRAPH"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.620:FF:000002">
        <property type="entry name" value="Major vault protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="17">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="16">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="14">
        <location>
            <begin position="534"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="864" mass="95972" checksum="0AF09ADB5874E3B4" modified="2023-02-22" version="1">MTEKGKRGGAPFGFAGGSGSEESIYRIPPYYYIHVLNHNTNVTTVETGPRTFIRQDHERVIFGPEKMAMVPPRHYCIIENPVQRNEDGSVIEDQSGQIKLNHADQEIRLTQEPFPLYPGEILKLPVTALKVVPANSALRLRAILDFDDAVAKTKRVAGDEWLFEGPGTYIPRKEVVVDETVRATIIKANQAIKLRARKETLDRQGDARVTGEEWLVKKVGAYLPGAYEEVVGVVNAYVLTDKKALHVTATRTFKDDHGVVRKNGEEWLITMEDTEAHIPQVYEEVVGVVAITTLTNRQYCVILDPVGEDGKPQLGQKKLVKGEKSFFLRPGEHLEKGIQGIFVLGEDEGLMLRSQEAFKDTDADVDRQPGDKWMIRGPKEYVPPVEVEVVDRRKAIPLDENEGIYVRDTKTGKVRAITGVTYMLSQDEELWQKELPPAVETLLISMKDPLADRGERGGSGSQKDKPREKTRVVTFRVPHNAAVQIYDYKEKKARVVFGPELVMLGPDEQFTQLSLSGGKPKRPNVIKSLCLLLGPDFCTDIITIETSDHARLQLQLSYNWHLDVNKNSTAAEAAKLFSVPDFIGDACKAIASRIRGAVAGVAFDDFHKNSAKIIRASVFGLDENLKVKERFHFPQNNLVITSIDIQSAEPVDQRTRDALQKSVQLAIEITTNSQEAAARHEAERLEQEAKGRLERQKIMDEAEAEKARKELLLLQANSAAVESTGQAKAEAQSRAEAARIEGEAAVEQAKLKAEAAKIEAESELDRLTHAREAELKYVTEQNEMEIGKSREMSEIETDKFNKMVTSIGSDTIRAIAVSGPEMQVKLLQSLGLKSTLITDGNTPINLFNTAQGMLGGMVASPETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BEF3</accession>
    <name>A0A914BEF3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_038074613.1">
        <property type="nucleotide sequence ID" value="XM_038218685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BEF3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218685.1">
        <property type="protein sequence ID" value="XP_038074613.1"/>
        <property type="gene ID" value="LOC119742588"/>
    </dbReference>
    <dbReference type="GeneID" id="119742588"/>
    <dbReference type="CTD" id="84304"/>
    <dbReference type="OMA" id="LCTDDGQ"/>
    <dbReference type="OrthoDB" id="242473at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037884334" description="Nudix hydrolase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="328" mass="36315" checksum="5FF09B4CA35E7AA7" modified="2023-02-22" version="1">MNECILFIINFFFTLQAATSNSMDGEFSLLFAAPNFPGVPQSNLHVRLSEDYNRKSLPSNEINIDRIWELRRKSNPRLYNGSKFRFHAIEVDSNGGDCSSCSAGVTFHLGITGYKNFMGTNWADNATELLESGVKDFANSQAYMSDALGVGSLVHTADECVVLIRRSSSVGEAQGLWDIPGGHPEPGEVKGGSSKMEDITLSDISELDVSKELVDSAMREIRDEINIPKSKLEEPHLMGVTRNHTSSGRPNMQFFVRCTLPSSEVRQMYRAGGAEAEESTALKLIQLSDIFYLESTDMWKEMAPAAKACVKLYTTLRNNLSDSENNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFD3</accession>
    <name>A0A914BFD3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074963.1">
        <property type="nucleotide sequence ID" value="XM_038219035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219035.1">
        <property type="protein sequence ID" value="XP_038074963.1"/>
        <property type="gene ID" value="LOC119742836"/>
    </dbReference>
    <dbReference type="GeneID" id="119742836"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="27530" checksum="FBDED5B090E154E5" modified="2023-02-22" version="1">MICLTTTCMNGCPNDLYYERLPATNTYQWGAWIPVELNQLSAAFFTWEILLKQTLWVLFADNSGGHCPHDYARYNPNIPTPGCGGECEGDQDCSDGEICCVKTSQSEYQCPVCRQPEYGKGCDTRFGEYYYDGEIFNSYNPYYYYGCTICQCINGEVNCFNTCDEDRFALREWIVPSITAAVALLVVLIVSLVVCCCVKCCCKTGHRTVYHGVGTPVQRPNNYQTCPPYMPNAGEREPLVNPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BHF6</accession>
    <name>A0A914BHF6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074867.1">
        <property type="nucleotide sequence ID" value="XM_038218939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BHF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218939.1">
        <property type="protein sequence ID" value="XP_038074867.1"/>
        <property type="gene ID" value="LOC119742770"/>
    </dbReference>
    <dbReference type="GeneID" id="119742770"/>
    <dbReference type="OMA" id="PAITHIF"/>
    <dbReference type="OrthoDB" id="6143588at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="57309" checksum="A925E1CBDC88F1CB" modified="2023-02-22" version="1">MLETEDPDVIAGTETWLHDSVYSSEFLPSSYQIFRNDRQTDTSGGGVFLAIKSNLMAKEEPDLNTNCESVWASIHIKGNPTLYLGAFYRRHFGSTATNQVYLKELDAAISKLTNNCQIILAGDFNLPDVDWVKTYFTPGGRYPALSKQMIDIAQDHNLHQVVTSPTREDNILDLVFTNIPSLVQNVNILPGISDHDIVSVEILTSSKRIRQPRRKIFLFKKGNFDKIKEDINEYADSISKEVYSAQSTDTLWLGFKHALTTAMERHIPTKMTSTNSSLPWFKQSHKCIMRRKRKAYDKARSTGATSDWEIFRQLRRLLDRTLRKSRSKHLLDLGENLTSNNTKPFWRYIKSLRQSSTGVSTLNTAKGIATTPIDKANALNSHFQSIFTKENCDNIPNLDSPKFQQMSPIIITTAGIKKLLKELKPQKAPGPDGILPTILKECADSVAPLLQQIFQKSIDTGELPDDWLRANVSPIFKKGNRSDPSNFRPNFTDIHPLQVARTYYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJ63</accession>
    <name>A0A914BJ63_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038075871.1">
        <property type="nucleotide sequence ID" value="XM_038219943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJ63"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219943.1">
        <property type="protein sequence ID" value="XP_038075871.1"/>
        <property type="gene ID" value="LOC119743521"/>
    </dbReference>
    <dbReference type="GeneID" id="119743521"/>
    <dbReference type="OMA" id="RAYCASW"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF10">
        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="481" mass="53583" checksum="52705019284C41E6" modified="2023-02-22" version="1">MASLAWLVVARIAVVLPICLWFVLAVSANEKSIPVWTWLDGTTLVNQPSTLTAGSQYPGCRAESGIWTPPTAGVVWMYGGREGSGMALNDLWLYDMPSQEWTNIQRGKEQSWPKPRYGAAVCGVTNSSVVVYGGAQSTENLLSDTWLYHLHNQSWMLLSDSSQPGVRANMVHWCTHDALWIYGVTSSDPNAPQTMWKFSFQSFDWTEVGGDTGNRGSPEEFRDLGRWKTAAWVVKNSHFYILGRNPPLASKSCQGKTSEVKNKCDLWRYSSLSNEWEHISTDAKADSESAGVVEQPSCLASAAFWPDASGNLWLLDSSNGTDSTCEETSQTRSNLWMLDLRLMRWISFQTHNPQSEDVLEWSQDTHSQPPPRAYCASWSRNNTYYLFGGLARNGSVGALNDLWDFQLLEVESLHPSPIHALAVPPVAVFFLSLGALGILSLFVFAVIFFTKCSAGPRLKPPNHFGDKIRYSPVEMDEVLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKE0</accession>
    <name>A0A914BKE0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASP family protein member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076385.1">
        <property type="nucleotide sequence ID" value="XM_038220457.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220457.1">
        <property type="protein sequence ID" value="XP_038076385.1"/>
        <property type="gene ID" value="LOC119744510"/>
    </dbReference>
    <dbReference type="GeneID" id="119744510"/>
    <dbReference type="OMA" id="NNHREED"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024845">
        <property type="entry name" value="NHS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039:SF9">
        <property type="entry name" value="LOW QUALITY PROTEIN: NHS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039">
        <property type="entry name" value="NANCE-HORAN SYNDROME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15273">
        <property type="entry name" value="NHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1738" mass="190127" checksum="B4671552C6F94F95" modified="2023-02-22" version="1">MPFVSRRVEPLYLSNRTLPNGCSTELENVANNTLANLVRQLANIADHATGIFDGICSEARDIYDRSCRLRNRAETLVEYMNSLDARSVEVPVSTLSDFKSLTDHFRYRSPVQENLITPVSRPQCIELQYRKASTDLKDIFEKLREYHEDEVTVCNLCQSISLSRLNCDTDSSEYDIEFPRPTVYDSNEQRRRKPLLPYTKLPARPRSEGDLLDDYVPPNRGTLPTPEEVMRRNVTQSMVINVDTSGTGFERMQTFRRSLTSMGRKLEKAKKKRWRRTISGIPDEVQAELQTESAGEGDGRSTDQENDVDILKTMSLDRRAFRQVKPVESPAAGLAVVTPIRTRRRPRSLRLPGPLVFPGLQQWRENHHQSKQDKKQEAKAGGRDRHSVALPVQTNVPTPSPSQGYSSCSDDKAWPGPAHRRPQSLALPPGTAPQSQAPLLPLSPAQPSNKKLYVTSNRTVPNAFIPTKSVTMTINMRKPAAGSGDAPDGLPLNELQARLPSTKVKLRNTKPTAKREERQSSSGNWSGTDSARTSMNSDIGNSLNYDFSSSNTTSPSDSAVSLSSENISFPKFNGGLKGLDRKHSRGKSDRPGNHTYASTGESSSESSTPTNSPNVVHSGFTHMDTDSWLQSVGAATVRRMPPEAGNVAPARKSPKGQCEVIFTSDTLSDSSSSSENPASSSAMSDNSSIDLEVYLADVNSDFVDSDSTSGHSVDHEGYWTSMHSDCGLPSRRIKKRKSSLTKEPVPINLKNEPPFVQPKPKRTSLAVAAPVVPVSTNQKKRPPPPPIRINSVSLDHSLGTRQKDRTQIEVGGRKSLSLLLPSSHQDDDRSISPSSLTDTASEASTIGSDTTTTPTLTPVQTPTDPAMYKLCFGGSSKSLESLDSQLSGSQGTQPCRVDAWTTEVSKGFAGNQQAATSSGAVVSVSNVTVSTSTSMAPFQEQASVAKFRPQVIQPSSSVLPRVSQAQPLSLPQPTVTQDSPTHEGKIKMLNARDKFFGISRAESTVNHGIASDATKGVTNSEEQSLQDEALENEEIVSPIGVYPENYNTLKRRPKHETDALKKSAGKQNQESSKTVSEDMPVSKGFFSDELSEASTPEGITVASQAKKGMDTLQRKRFQDYVSSVQNQAPQNYNSINSLKESASGNGTQALTREQREEILNMLRRTKNNKVASSPTLPEPSSKKFEDPPKHELGRIHENVAVQEQVHNRDEESGGKASFRSTYHVSVESENLDPDLAIIRAAEQMEQQLLQKRQRANAPSPVQTQGDNIWVPNAQPFSRNSIAYRSMYDSDMCGNSFSHVPSMDMDDSYVYDPNLRPKSSILKVRKQGDASLNETKSNGTKHLFTPSGRHGQTMSPTDSVSSLNSIRSITFSDMVDVEHTPVKICLLSGKPQTPMDDFKMLLQQQSNSRKGQSACSALNVQPKSQRPSNNAELLYSGIRTGTIQEEGAKAQESSPDSRKIVTMKDLRSAMANPRTNSRTGDLGLPYEELQTQNRQRSPKNSPSPSPNGTLNREDKGVKFDFEQPQYVASNATAGNSVDTGRGTSLPNGNVTDADKSRQLLKTGASNQGNSRHPNEQKSNKTVSKSPSGSDAQQTSSKVSAIKPKSKSTTPGNKSQDSLPKQAQSAKSPPDLISRILPRMTESASDSILSRKDLMDEIRQRGTRRDSRQEAVSELETQQLQRKLSASSMPTLMTSSTAQPSRRSKGLGSLLDSMKTALKSMAVASPAGEGEHENDSGAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKN3</accession>
    <name>A0A914BKN3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076669.1">
        <property type="nucleotide sequence ID" value="XM_038220741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220741.1">
        <property type="protein sequence ID" value="XP_038076669.1"/>
        <property type="gene ID" value="LOC119744679"/>
    </dbReference>
    <dbReference type="GeneID" id="119744679"/>
    <dbReference type="OMA" id="NAHTENT"/>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="84454" checksum="A43CC27D9A2234D6" modified="2023-02-22" version="1">MSYRRPSAPHEPFWHSPGQRAPSPYQRFPLDDFNQSTDFDVEDFIFHNERPASHGYGYEPHYQPVAEPPEYRRREPSPLFGQGPNWTQHGRQAGPPVYNHHPRDEMHNRRMGTSQQAGPTFNQPPPQARQGPHPQRNPQKGRALNRADPLPPQAHHAPRARSEVRQVRKPEVPPPGVEEFTCTDIASNIAEETQPLPVAHPGPPPEPRQDTSKDNDKKNGSSDDIILHPVTKVPVKRKPNGTYELVEDETKKKAKKARPPSPPPRPKKLPEEIGDGCYCELCDLVCSGPLNLRMHISGAKHKLNEAKVEKGEKVVMRKHLGKKIKGRITKEGPIPATHNQEETPLIGLDYVTRVVFPDKDASEDLFECSLCDKKDMMYASIYQHIMGRAHRKAYIRKLKPDLADQYSNIANVYDKNGQLQRRQNSDLSALLNNISKIAAERDGPGEMQIRLSNERETDGEDIEDYGVEGYDSDPDVMGCLPPGTEPENRGSVKRLGQNHPHLSAEPPEYPAIPRPPYSRQDPSERMPQRDTPVLPHSRLQPAGRGTPEPPITRLHPRSPSPDRPPPVTRLPSRALSPEEVPPHAPPTPINHALPSVTRLPPLSASPRPEVNAHTENTPPPMTRLPSKETPPIMNQIISPADLPPLTDEQLRFYCSDVFIAQEYRRRFGDPKPPASTAQPEGTQDNTQTKEISDSANAGGITVETLLKSMSNSMVNNEEDASMAMRITRALTQATLKYRLREKDFAVQKKDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL54</accession>
    <name>A0A914BL54_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076834.1">
        <property type="nucleotide sequence ID" value="XM_038220906.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220906.1">
        <property type="protein sequence ID" value="XP_038076834.1"/>
        <property type="gene ID" value="LOC119744775"/>
    </dbReference>
    <dbReference type="GeneID" id="119744775"/>
    <dbReference type="OMA" id="YHEDNYY"/>
    <dbReference type="OrthoDB" id="6144055at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056245">
        <property type="entry name" value="KH_DEAH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056248">
        <property type="entry name" value="RBD_DEAH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24471">
        <property type="entry name" value="KH_DEAH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24475">
        <property type="entry name" value="RBD_DEAH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="731"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="946"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1148"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="2216"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="2220"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2434" mass="273456" checksum="57044567672E5400" modified="2023-02-22" version="1">MDNSPRKPKSEKKWMIQFSDSGSDDEMEEREEEEDEGDGEEIEKEMGESTVVQIYGIDVHSKATWSVLKSYISQHAEGLKEEGEDTLLPTQPMTLHFESQAAAQKACSVLSNLMGPSSNEIKFEILNTEGIQNAYDVGQQPAVEEATGKTKKPGPRVRHRKPRERERKKRVSGDGLDPTSSATLEVINVGIKKDEFQKLLTQLKITCQSLFWKQQPNGSKVFLQFRRQEDADATLKILNNLSVGAANQKLVAKIVKPDSTGGKGLGQTPAGAASLSEPFQKGPARASADRSQKNNRYGNSSNRSSRGGHTRVVGKQPEQHGLDGTCSSHRQTRGPGQMPRGPSKIPSLIELPLQKPAGQQRERSSVCDDDDDDDRISAVSTASNASASPKVNSIEVTNIDPRVINIGFWHFLKDNRIPVEHLEFQTTMTQERCAVIYFATTEDTRRSQEFLHGRRIFPGGPRMQASFITTSNSNDHRRVDDDANDGQVRGATGGPPQHPSPGGYRGRGGRVGRGGRGGRGGRGGRGRSQNRHRKDEDESDKFSECSETVSVASRKSFASSNRGGRQYGKSSSLYITNIGKDCDEGELCGFLQSLDLECECLEFRQSKTTDTQYAVIQFPNCKKAGEGKKVLGSDEWVLGGSLIKVSFFWKNVSRGGGGSLATQLSQLEVEDVDSRSSIHTWLDKTNRLGQQDLESKNQASEPPNQKLPVGKKAGNGNPYQLKDKKREPNLKEIVITDLPKDIFEKDVVDILTKEKCRGFIDVRLVKNKDVRDRTSECFVKFREREQAMEAVLKLYGRPIHDHRCEVRLAVNHDQMEPAIARKTLISFQEKEMPDKVQTIESTIEGKIEKIVEDVQDLREVWEENLSYADQERCESSIVALEHQLNEQERYLREFKTACISVESAVDCLMERVVALSEVQRIRHRFERECRRAESPLPVYGYRHDIQETIQKNMAVVLQGETGSGKSTQIPQYVVDMELQSRHDGEDALTGVGQQWRVVCTQPRRVAALTLAKRVAEEYGCRVGEEVGYFVGNKKLVKDNTVVTFMTDRKLLNICMADPDLSEYTCVIVDEAHERSVDTDILLATLKKLLTKRRDLHLIIMSATIDIKLFTDYLGGCAKLSIPGRTFPVDKHWCGDDVGIGEGDYLKRAIQQAAKVHKNEGPGDILVFLTSANEIETACRDLKSALGLKTANDDESPVLILPLHGRLQPEDQMKVFAETRANQRKIIFATNVAETSVTIKGIKYVIDTGVVKECQYDPKRSMSLLKVTTITRASAEQRAGRAGRTAPGVCYRLYTKEEHGELEETMKPEILRVHLGMAALQLLELGVENVENFDFIQAPDRDATRQAMITLRLLGAVDEDAKLTPLGKKMATLPLEPRLSKLVLEGAKRGLATEAVALAALISAPGSIFYRGGSDKDKEKADRLKLQFCHESGDIITMLNAYVQWNNQPEKKQKEWTLENSMNSKTLRAVRETVKEVGQALKKEHSIDCNYSKMEAPDKVKSEDLQKVIMSGYFQTMSLYNGHHRAGYTVLPQQKSAHVHPSSALKALGSHPTWVVYEEFKRTSRDFLFNVTQVDISWLEEVAPVFHREIDLEALREMAMVELPPISLGTALMRQLIAKRNEKIRALEEEITDKQNSPCIIEINRSTKQLHMFVNKQCSSFAESNVKGFLEDERKRIERQQIEVPVGDSGVVRQVVIAGAETRFILMAKDYRTLEISNVPADATEDDVERIIRFAGCSREEIIDVYRFPPQTSMAKASKWGRVTFISPEAAEDAKKWLEVAAAAEETSMTVRAMQGRGFQRRDIRRVNTRLVVTWFTWPSKGHAFVNCDSTDNAVQLMCELAGLRLKGMMLIPKLKRNDTRAVLINGLHPDATQDDLEKAIERKTDIPFTRCYIVRREPAGSIPTPDEVTRDIYSMFDGAVEQNEMNIDILPVKSEKTQMHKAIVTFSGDNEGQVDARLAELQNNPRRNPQGQLYHLKITASCMLFCRPEVYGCLEEDIKQLVETAKTEKEDLVIRVNPSRKTSDWVISISSGRAEDVQTLRRSLLVYVQGETVPLSDLYHSQISHQKKSKVLEMLQKALRFLIDDLDAHAMIDTRRQAFVFFGKDRTRERLKRRFGDYVGIICNNMLREIPLTASVSPHCTKGRAIRALVKAYGPWLKGLQEKSESAAITMNTRQGVLLIEGNPTVFDKVHDLVYDCLKEAGLEDAMSVEDKQPVEDIECGICYTPVDGHEEVYRLSACSHGFHQGCIRELFNVRLKDSSKDYPIECPSDSCGRPMLLCDIRILCPEEDTRLKLYQLALEAHVAQQSDGKLKFCPTADCRMIYKHTDDAQTFVCPECRARLCSSCGAEPHRGQTCEEFKISGKNFDDIEEWMRTGVDAKKCPVPNCACVIEKISGCHHMTCKMCGKHICWVCLRFFDTGNQCYGHLQEVHGNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL84</accession>
    <name>A0A914BL84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine + H2O = N-hexadecanoylsphing-4-enine + phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
            <dbReference type="ChEBI" id="CHEBI:78646"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45645"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038076864.1">
        <property type="nucleotide sequence ID" value="XM_038220936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220936.1">
        <property type="protein sequence ID" value="XP_038076864.1"/>
        <property type="gene ID" value="LOC119744799"/>
    </dbReference>
    <dbReference type="GeneID" id="119744799"/>
    <dbReference type="OMA" id="SELGHAC"/>
    <dbReference type="OrthoDB" id="10010057at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09078">
        <property type="entry name" value="nSMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017766">
        <property type="entry name" value="Sphingomyelinase/PLipase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF23">
        <property type="entry name" value="SPHINGOMYELINASE C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364669" description="sphingomyelin phosphodiesterase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="445" mass="49784" checksum="4DA450F1AE46444A" modified="2023-02-22" version="1">MLKMLLISTALYIAVYLKGCSSAKHPDNEDEVRYRHNKQAQAARQASYEPRVWIDNAPDCQADASHCQHFGLEYVRSDTISELGHACEGGTKVMCTLPNVTPLANPTAVNTLKIISYNIFELPYSAIQSGQRERTCRIPAEIFKLQPDVDVIVFQEVFLGGCIVTDDDATSLTLRQILRAYGFVHFTQTVGDHEPKTLPKMFNGGVFIASRWPIVTETQKVFVNYDTVSIYEAMLAKGVVYAKVKKTNAGLSKNYHIFGTHMQSSELPTSVSVRLLQAGEIYEFMQQQKIPVDEPVLHAGDLNANNIGKPEHAQAVFDTLQATLPLLRGVLRITYDYQHNDFIEDTDPAEFLDYILFCRLHEQPTNSALEVFRPLIPDPLEICRGDIPYGSFMYPNDPDCPAVKTVTDLSDHNAVLGVFTYPQSTSSGKFVLTRSSGAKKQDIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLU2</accession>
    <name>A0A914BLU2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Damage-specific DNA-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076437.1">
        <property type="nucleotide sequence ID" value="XM_038220509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220509.1">
        <property type="protein sequence ID" value="XP_038076437.1"/>
        <property type="gene ID" value="LOC119744538"/>
    </dbReference>
    <dbReference type="GeneID" id="119744538"/>
    <dbReference type="OMA" id="CGHEHHN"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000161">
        <property type="entry name" value="DNA damage-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033312">
        <property type="entry name" value="DDB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15169">
        <property type="entry name" value="DAMAGE-SPECIFIC DNA BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15169:SF0">
        <property type="entry name" value="DNA DAMAGE-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="508" mass="57691" checksum="496446C00899490A" modified="2023-02-22" version="1">MKEKRQKENLLSRRVLRSRTAALSSTQNFNEKVPTEKLPDEKPKPTASSTKRSLQKSATDINENTWKTPEGFKPPNIPAVNPFGLNSCNMVHRLHHASLSISQGNRLKQAVVQPYIQQLVNFRIHSTASPFDRRVTALEWHPTLPKTLAVASKSGDMVMWNYKNAAKFDFNKGVGKGGSVTAMTFDLDDPSGIYSTSINGTFSRQCFGESQNAHRVFLNTDDYRHWYCSLSVNYARNLLIAGDNSGNLTMLDRKDGKALWTRRLHKSKATHCEFNSRCDWLLATASTDNTVKIWDLRMMTDRKSALFVLNHKKPINSAYFSPDSTRLLTTDQNGELRIYAAPLWDRMERSIAHPHRFFQHLTPIKATWHPLHDLVVVGRYPDENFPGYREGEKRSIDVFDANTGEMVCQLLDPSVSGIASLNKFSPSGDSLASGMGYNILIWKDIVKLQQILSEKSRRNHDDDNSEDSRAPQPRIPGPAPRRRRRRNNDDDDDIGAMKKRLKGKLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMR4</accession>
    <name>A0A914BMR4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077235.1">
        <property type="nucleotide sequence ID" value="XM_038221307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221307.1">
        <property type="protein sequence ID" value="XP_038077235.1"/>
        <property type="gene ID" value="LOC119745085"/>
    </dbReference>
    <dbReference type="GeneID" id="119745085"/>
    <dbReference type="OMA" id="YSHKNEI"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037023542" description="C1q domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="141"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="278" mass="28583" checksum="BA27AF9B10BD244C" modified="2023-02-22" version="1">MKICVATILSIALLLGNSVKLRASVTGPVPSDGDGPASQVCQQCCQGPAAIPGIPGLPGPAGPMGPYGQPGSKGDAGQQGENGPIGPMGERGAPGNTGSKGDDGIGLPGKIGPRGLPGFVGGTGETGVKGQKGEPGETPDDLNQRVAFTVVRTSDSDESTSSVTHLPFQQTVTLLPGTSFDLETGTFTCGVPGTYVFTFSVLKHSNSGQLVIHLVKNNYKVITTYGESNQRGQLSGSAVLVLQRGDTVYVTMYGRARSHSTEHYTSFSGFLLYPESVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMW9</accession>
    <name>A0A914BMW9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077638.1">
        <property type="nucleotide sequence ID" value="XM_038221710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMW9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221710.1">
        <property type="protein sequence ID" value="XP_038077638.1"/>
        <property type="gene ID" value="LOC119745390"/>
    </dbReference>
    <dbReference type="GeneID" id="119745390"/>
    <dbReference type="CTD" id="5204"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18923" checksum="5C2E54D069FD3847" modified="2023-02-22" version="1">MKLKFFDKMAGGSGEPQAIDLMQLALPQLNMLKEEIEQEVEVLQGSLQQLKIAQGRFIESTDSLNKFKKPESEGKEILVPLTSSLYVPGKLKDINNVLIDIGTGFYIEKTLPQAQGYFKRKVDFVTKQMERVQPVLIEKSKMRQVVTEVMNMKIQAQMSATQGQGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN46</accession>
    <name>A0A914BN46_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076892.1">
        <property type="nucleotide sequence ID" value="XM_038220964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN46"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220964.1">
        <property type="protein sequence ID" value="XP_038076892.1"/>
        <property type="gene ID" value="LOC119744814"/>
    </dbReference>
    <dbReference type="GeneID" id="119744814"/>
    <dbReference type="OMA" id="THMLLEW"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="312" mass="35034" checksum="4B38848196A8AC3E" modified="2023-02-22" version="1">MNSSSTEPSELSPVLVALRTTFIICLGVLIIAGNLLSIAVTRHVSDLAESTKVLMITLAVSDLFIGFSTAFGVVASAMDRWPFGRICCQLMPVVQMVVSFMSVFSVVLLNLERYIAVTRPFKYPIWCSRHRILALVLVFLVLSVFNSISLQFIFEIPSEYLDSSAVCFLRMTSKYGGVIFLIVLVILPVSIMIRVYHRLIKISREQARRIDPNRRNANPSFYDNRALKAFLVVTLTLAGCFTPLMLCRSVESLAGVALPGWLEFSAVWLVYCNSALNVFIYCLFKQSYRRRAMGIVSKRLLCCRNSVEPVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BN89</accession>
    <name>A0A914BN89_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076942.1">
        <property type="nucleotide sequence ID" value="XM_038221014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BN89"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221014.1">
        <property type="protein sequence ID" value="XP_038076942.1"/>
        <property type="gene ID" value="LOC119744842"/>
    </dbReference>
    <dbReference type="GeneID" id="119744842"/>
    <dbReference type="OMA" id="FYDDIQC"/>
    <dbReference type="OrthoDB" id="6282214at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035592">
        <property type="term" value="P:establishment of protein localization to extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF25">
        <property type="entry name" value="SPARC_OSTEONECTIN, CWCV AND KAZAL LIKE DOMAINS PROTEOGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037961984" description="Thyroglobulin type-1 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="478"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="622" mass="68496" checksum="77E7458DBC558518" modified="2023-02-22" version="1">MNFLGGSRILLLCGLVLAVSAAPVQEPEVKPSKRHNLNSDKEQLLAKLKDIEKKLEGRRSSQVPGDDNPAAAAEPRKKEAGGASTRDEKLVASLLGRVSKDKASQDGVDPGKKALQQFLDKARVSGQFVDEPFSDTVLGQIPGDNQKEEDDIVKKEVNDFDKNDKTAMVDSISIDDLKQMLSDFKENKRELDNNDMLARLDFLTIDDLKQLLSMLRQNKPGYSPRGLDGEDANDEDGQDGVGETGGDDDDDDDDDDDDDDGDSNGFLQGISVQELKELIETVKQKKQDGALTPGDLGKVVYYLVTHLTTDDLQTMLDAAKDQEKEEEEEEDDDDDDNDGMTEEEIGQAIQNLVSHISADQLQSLLAAVKARKQELDDNSEESKESSSEDGLDDRELHQTEEEVMQALLDFLSGLSTEELQKTILAVKRKKMEMKQAVGDITGEYIQANDDTNDNDDDTHIDDDVTNDGNNDAVESDDLGPCAQEKQDILDKIEAARLANSHLLGGEVPNCDEDGFYAPKQCSGSMCYCVDKHGTVTEGEAMIWEATSLVCSQDNDDASSDSSSEEDSSSDVSEDDKDDDEDEESASDDDDEEVKLEQVERDLLEMLKEQKRQQLSKNGGLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRA2</accession>
    <name>A0A914BRA2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase-like hydrolase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078171.1">
        <property type="nucleotide sequence ID" value="XM_038222243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRA2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222243.1">
        <property type="protein sequence ID" value="XP_038078171.1"/>
        <property type="gene ID" value="LOC119745703"/>
    </dbReference>
    <dbReference type="GeneID" id="119745703"/>
    <dbReference type="OMA" id="RKPIESW"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07509">
        <property type="entry name" value="HAD_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000060">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01458">
        <property type="entry name" value="HAD-SF-IIA-hyp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="260" mass="27925" checksum="5ABAE2DAEDE29C03" modified="2023-02-22" version="1">MMAVRAVLRAVLIDLSGTLHIEDTIVPGAVAALARLRSAPVKIKFVTNTTKESVSTLHQRLQKLGFDIGVGEIFSSLTAARNVVIEGALRPMLLLQEDAMRDFEGISIDSPNSVVVGLSPDNFNYATLNSAFRLVLDGAKLIAIHKARYFKRLDGLALGPGPFVEALEYASGTKASVVGKPEKTFFLEALRSLGCSPQDAVMIGDDARDDVHGAMAAGLQGILVKTGKYRHGDEDRIQPGATAVCRDFPEAVEHILSKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BST7</accession>
    <name>A0A914BST7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPGRIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038078582.1">
        <property type="nucleotide sequence ID" value="XM_038222654.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222654.1">
        <property type="protein sequence ID" value="XP_038078582.1"/>
        <property type="gene ID" value="LOC119745943"/>
    </dbReference>
    <dbReference type="GeneID" id="119745943"/>
    <dbReference type="OMA" id="HMERIRF"/>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000073">
        <property type="entry name" value="protein fantom isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021656">
        <property type="entry name" value="C2-C2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041091">
        <property type="entry name" value="RPGRIP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF1">
        <property type="entry name" value="PROTEIN FANTOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11618">
        <property type="entry name" value="C2-C2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18111">
        <property type="entry name" value="RPGR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="777"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="274"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="494"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1406" mass="160396" checksum="F0933C5BDF69026E" modified="2023-02-22" version="1">MDADSVYDETPVRDPGGGARGHELPQDSEQRRAQQRRAVAKISREELEDKYLRLHDENLVLKRHARKQEEKIKKMATKLLRLVSDRKKQDQEEGGAKRPARKGRDVETEEMLEDLQGKVRELHKQNDLLKNKLMVTKQQLATQGTRSTPYPHVQSRINTGLPKPPPPDNVRKGLRVQGHDRTKSATPRAFRTDVLPRYGHSLLEEAREENHRLEEMIQDLQDHIASLEQDREILQEQVRIKELEHDETLLRLKEKMSAGQRHTAKTNIHENVEMIRLQREVKEKSTKLQALKSQFANLEENLRTVKKSHDTVLAEMEQLNKRYQKEQSKVLGLQSELKESSTSHRTIMELQERIGNVENEKIILQEANEKLLNSAFDAERERQYRANEKQLKLQIAQLEATLKGDLNDKNTLLDKLNEEREQYEKLSKENQQLQISYYQVRQQLDELQEKMKFFTRESAVDFQELEEALIIVKKRKEKGSQDLEFLEKVDEEMNKDLKAQVVSLQAEHAETVSELEKTRNMLILQHKINRDYQIEVEGATTRLEDYKQEYETKLEEYAQLLDIRAARIKKLERQLRDVAYGTKQYKVTDIADDDDYEEIDETIKLERGQNLLELHVTRLVYSREGLKALGDENPSTFVTYAFFEFELQSTPILKGDRPQFDFTSQYKVTVDDFFLQHLMKGSTTLEVHQAIGTEYRTIAACQLRFRDLLDKPQGRLHGMEQLLGLERAGVNFGTIEFWVRLRVPMDQALRLFRERVKAMGYVMSNTRTANQAIATLDQTEGREDTRGQQRDNLNELTVKVVRCAGLKPRREGVQPNPYAVYRFFDFNDHDTTIVTSSNSPEFNDANVYPVVMTAELDQYLKNDTLGVYVFDDTDPEDMAYIGVAKIPLISLAHDKAIRGTFELKQSDGKVNGTIDMVLKWHSTYFAPKLTSGKPKPTKPPTTPSKQAPIIAHRPPIKPVSAQAAPAVTPSKQPKPLAASTPSVPRPRSGTQPTDAAASEKVVERTRPLPRPRTSSQPLEPTPRKTSSESLKNPVIDVTPPSQEDQTNPLSVTQTLEGDRPAPAPASVQESPFDSEEDAVLDDVERELEGLSRGQEQVEDSAEDVNDLVAQEMRDEFGQEEEKIGKTEQFEDTMFGDTSAPGTGDDDYDEDSIAEEVDIPEPIEEEDEEDGEGEEEDEEAELDEEEEEVGAGDAGQEMMEGEVDDDEGMSSDSEALVVMSPAMNRPMSVAAGDNTVSVTIFHLSLEPDTPVITDDNVQRLYVEYHFLGLSGEETETPFSLPKPKAYHNLVYNFKKMFHVDAENNKLQRDYLVSMLHPDDATQGKIRFTVVSEPLEESQDLECEDVGYAYVDVRDMLREDEDMIEQDIDIHYAKEESILIGTMNVSVECVAALRAASAEVDYSNANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YZI5</accession>
    <name>A0A913YZI5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038045119.1">
        <property type="nucleotide sequence ID" value="XM_038189191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YZI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189191.1">
        <property type="protein sequence ID" value="XP_038045119.1"/>
        <property type="gene ID" value="LOC119719696"/>
    </dbReference>
    <dbReference type="GeneID" id="119719696"/>
    <dbReference type="OMA" id="MAVWLIV"/>
    <dbReference type="OrthoDB" id="10148204at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="40263" checksum="772EFD95A7BB0C60" modified="2023-02-22" version="1">MDNSTTNSTSYEFSDYTQRAIVATLFLIVSLVGIIGNSLVIIAVLLSKVLQTTTIAFIVNMSTAHLMCSLVLPWDVVALLSTGDLPRGDREWLCSVTTVVVSITIGCGIYTLASLALNHLLLIARPTTTYLKIFTPKKIAVWLMVTWLIPIFVILLPPLINLGEVGFNDKFHLCGTKSSDQAKFIIYNFIRVFGLYPIPLLCIIVCYALIWAHLRRHIGETVSSVGDDTPTNKGIPMEENLGAGIDSARSSSASLDTISPTHMINKTMPFVVGGFIVLLLPYAVCLFISSFEPAVPYATTILFSSCCVNPIFYGIRHRDFKNVFGCILRRRWNDIPQPSPFLKATRRIQCCSKRSVVHADEHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0I5</accession>
    <name>A0A913Z0I5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038044511.1">
        <property type="nucleotide sequence ID" value="XM_038188583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0I5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188583.1">
        <property type="protein sequence ID" value="XP_038044511.1"/>
        <property type="gene ID" value="LOC119719213"/>
    </dbReference>
    <dbReference type="GeneID" id="119719213"/>
    <dbReference type="CTD" id="8453"/>
    <dbReference type="OMA" id="PRPVWND"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000016">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000018">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000022">
        <property type="entry name" value="Cullin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="387"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="742" mass="86175" checksum="3A315A2480EA68AE" modified="2023-02-22" version="1">MSLKPRVVNFEQTWDRLLETVKGVIQLGNVKRKIWNDRFSDVYALCVAFPEPHSNRLYEETKIFLEEHVQTLYKDVVQAADGLLTIYHRHWQEYSRGASYLDQLYSYLNQQFIKRQKMSEADRTFGYSLDTGEEQLMDIGELALDTWKRLMIKPLKKNLHELLLREIHRDRCGEDTNQAVLHGVINSLVDVERYRQKDQVQLYQELFESKLLTETGEYYRKESANLLQNYNCSQYMEKVLQRLQEENFRSRKFLHPSSYNKVMHECQMRMVADHMVFLHGECKNMVRNEVLADLSRMYKLLKPVVNGLHIMVNELQEHIKQTGLQAVSSLQGENIHALFVDAILALHSKYTKMICETLGKDKVFSMALDKACAAIVNHRPHPRQPCKSPELLAKYCDTLLKKSAKGVSESEIDDKLQQSILVFRYIDDKDVFQRFYARMLAKRLIHGLSTSMDTEESMINKLKQAFGYEFTNKLHRMFTDIGVSEGLNGNFNTFCQDKQVDLSVNFSIYVLTTGSWPLGQSTLAPFAIPQELEQSVSKFEEFYSEKLPGRKLTWLHHLCTGELKLNYLKKSYIVTATTFQMAVLLLFNSQSCLRYSELLESTQLGEKELQRTVQSLVDVKLVDNKAQDDLDTSASYVLNMNYSNKRTKFKITTAVQKDTPQEVEQTHVAVDEDRKLYIQAAIVRIMKARKQLKHNILIQEVISQAKARFSPSVSMIKKCTEILIDKQYLERTASADEYAYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0V1</accession>
    <name>A0A913Z0V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 11-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STK11IP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045291.1">
        <property type="nucleotide sequence ID" value="XM_038189363.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038045292.1">
        <property type="nucleotide sequence ID" value="XM_038189364.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189363.1">
        <property type="protein sequence ID" value="XP_038045291.1"/>
        <property type="gene ID" value="LOC119719896"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038189364.1">
        <property type="protein sequence ID" value="XP_038045292.1"/>
        <property type="gene ID" value="LOC119719896"/>
    </dbReference>
    <dbReference type="GeneID" id="119719896"/>
    <dbReference type="CTD" id="114790"/>
    <dbReference type="OMA" id="LMQTTKS"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000658">
        <property type="entry name" value="Serine/threonine-protein kinase 11-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031782">
        <property type="entry name" value="LIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057292">
        <property type="entry name" value="PH_S11IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057676">
        <property type="entry name" value="PH_S11IP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15904">
        <property type="entry name" value="LIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25357">
        <property type="entry name" value="PH_S11IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25624">
        <property type="entry name" value="PH_S11IP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LKB1 serine/threonine kinase interacting protein 1 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein kinase 11-interacting protein PH" evidence="10">
        <location>
            <begin position="568"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PLEKHM2 PH" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="STK11-interacting protein C-terminal PH" evidence="11">
        <location>
            <begin position="1397"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="934"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1519" mass="169071" checksum="1C51DE63C0C17F43" modified="2023-02-22" version="1">MQATNSLQELTVFLQKNSGKILNGRCNLALTSHTLAHLNRSFRQCEEESSVDSGSHDQHQSHDRRWPQTVMFLLNYVKKTPALKLIHPTSTLQGQVEISRFIGLTMLEIKKVPVHMLNGLGCLRHQLQVLICSRCVQSLQLLLCSCGGDMVSEAPWSSLHTLNLSYNYIDHLDNSLRLLPVLKMLDLSHNELKHTRDYLECLSELAHLNLGYNHLERVPTLGLVARTNLQTLVLRNNSLDNLSGLEDYSSLLELDLCNNCLYDGAELRTLGYLHNLREVNLLGNPLAFDPAYRSVVISKFPPEGATRKMYLDGVPLTSTENQQIPRVGLTKPVLRVPSEASFDTSSTFLNDHSSFDESTDLDKGKRSKGKRAPKVRQVSIPDQGVHKDDAKSKASVLRHSDIEKTKREHEKMRQLHGADWLLALQAPYRQSGADTSESETEKIVERTRDEPKANRDNSLGPCSSGIESDIDSTINGNIIVHASADGSRHVDNIDNTKNDNQGIMEEISAVPSSDVFLPEVKADLKRVSTGQTHVLLEQKNSKPSIFLERIASDSDAAFESPWIEGTPEEEEHELCSPLLVTVQESNQDDPVHLFLTVRETHLEEKNLNGHVTERLEIKCLKGMQESIEPVWNEEAGVNDLLPVINLTFDYMRRDRKKREYILEDQESFRILSKTLRPFLEENRLAATTHQKAMFQCLKCSTEFAGHQAKRKLPAQQGTIRGNYNSEGEGNGVCPFCDSELIVELENPASPSNHTSIVSTPTGSLNSLEMNLRPMASSSPWKVKDKDSVLLSSTEKSRSGSSTEYHSAANSLSSSPGQGMTFGQAISSSSSGTSTLVNSSSLIATSTIKRERHITEESIEDNGSAMSATSDQDTAQESNFALPDPTIRMSRGDETNPLENISTYQHEKLRELLQENMAPFSQKYSLVPPDILDGVSSREVSGATTPRSGETSNPPSRNEIDNAVNSPAERIDNDKTSQPQEDRMRTKSKSNSSTTLKQHRNDTPDKIQNRGSRPCSEDDIVILPAEKSNHERLEVSFNGSNDSTQDTPSYDTVSGVGRAGSTDSEIAVLRNNSIDAVSINSDSVFDTSLNAAPTNLANALSDAASKPDATNSSLTPTIDEPHAEIETSGVPSRDVGEKTKHENLDRNGRKSPTNKPSSQKTSPSKESSLNSSLEASVSLSMPRKHSMLEAIDSDFTNVDHRLKLYFSMSLFSGKEELACMIKCGIFQFSKSANFSGLLVVSTQNIYIMRISREESEKPSDWLAKRSQHSVRDLLHIHVGPGSQSFQLDFNNEGILYTIVLRDEEMCEAFVSQLEKAIQRAPIGKKRRFKGVARDHPNTLMNIMSQVFGESMDEGVLERESEISLYMLAYQKTTKSVKRGLLRLDRKISSSAPKTMALDLVPVSIVVTPSDLYLAEENHWWPLRQTKTKGQTKLPQFTLKDHHTITDVGEVELYEDSPSDISITFFHEDTADQSHWHISTENTSSLSRLLDAIQTPWKDMFGVDLKQTVHPTLTVEEEFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3K7</accession>
    <name>A0A913Z3K7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045596.1">
        <property type="nucleotide sequence ID" value="XM_038189668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3K7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189668.1">
        <property type="protein sequence ID" value="XP_038045596.1"/>
        <property type="gene ID" value="LOC119720118"/>
    </dbReference>
    <dbReference type="GeneID" id="119720118"/>
    <dbReference type="OMA" id="MHFTMGT"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="295"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="397"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="68930" checksum="8C04E5B1E2171CA4" modified="2023-02-22" version="1">MNSDPSHLGEDVGGEKGGGSGESSPLRWEELNSRGQDSSPPGYETIDIDLTELPPGPAENDVQGDDVTDWAPIRQSAFNKQIDRVDKVIKGALKSQWKLIKWVIFGVLIGLYAAYVIYAVVLDFQRALALFIFSLLALAYALYRLVKHVFGARLVSAVVGCKQQKCGLFLKERRLIINCFMYILFTGILITMCALSGVIDSVISEPERLKSLFGLFCMLLFGFVFSRQPGMINWRTVFWGLWLQMFLGILILRTQPGYDVFNWLGGHIETFLSYTNAGAEFVFGPAPLSNHEILLIVLPVIIFTSCVFALLYYWGVMQALIMALAILMHFTMGISGAESFATASNIFVGMTVAPLAIKPYLNDMTESEMHAVIVGGFATIAGSVLAIFISFDISASHLLAASFMSAPAALVTSKMFYPESKKPKTASISNIKTAKAVENNALEAMYVGAIDGLKICAYIIGNLVAIISVLAFVNSALMWLGSLVNIEDLSFQLICRYVLYPIPWLLGVDGPDCLIVAELIGVKLFLNEIVAYGQLSTYVKEGVVSTRSEVIATYALCGFANLGSIGVMMGGLIPLVPHRKSEVSRLCVRALLASCVALFMTACIAGLMYDENKVFQPISPGGGGNLNATATTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4C7</accession>
    <name>A0A913Z4C7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045846.1">
        <property type="nucleotide sequence ID" value="XM_038189918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4C7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189918.1">
        <property type="protein sequence ID" value="XP_038045846.1"/>
        <property type="gene ID" value="LOC119720275"/>
    </dbReference>
    <dbReference type="GeneID" id="119720275"/>
    <dbReference type="OMA" id="HVVSYTN"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45522" checksum="14ABCA5D64D11291" modified="2023-02-22" version="1">MVSCGMLQPSLKAVLARCLFAIHGIITIWRVTEVNSDTVYYLLIIPVLLLPLEMIVTLKFADNGEWKWFCPSVLLYLTSVVPGLWLLQFDLYETRIDYRDSNDLEDCSGEFAYNSSGLTSDVAGLQISIPLSLAADVWAITLEQILIALLIVGRWLLPKGALTREQLSQLLLVYIGMGADILEFFGESVEEEAVVCNLPLITLIMLFWSWSLSQFTLVRTSVSAPQTKDTKRRKSMVSGGLGGCFGSEIWGLCITIVMQDGPFLVMRLYLIIAYNASSQLLLFFTIKNILVILLQLYRMAILPCASLFPGESGDHDIEGQQAEDTTDKSNEGSQAGDDDDEEKSEESNREGDQGLDNEGQQVEKTTGKSNEGFQADDDDDDGDDDDEEEQPEEVNYKGDQRPSWIGTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z4H8</accession>
    <name>A0A913Z4H8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045901.1">
        <property type="nucleotide sequence ID" value="XM_038189973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z4H8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189973.1">
        <property type="protein sequence ID" value="XP_038045901.1"/>
        <property type="gene ID" value="LOC119720331"/>
    </dbReference>
    <dbReference type="GeneID" id="119720331"/>
    <dbReference type="OMA" id="WGMVANA"/>
    <dbReference type="OrthoDB" id="5979489at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42719" checksum="4A154AFA7FDC5CA6" modified="2023-02-22" version="1">MDLNQTQLHVKAKVTKADGSNLAEADHMGPVNLFLQSLFSQIDVSLNDRLISPSTPTYPYRAILETLLSYGSDAQISQLTAALFYKDTAGKMDSADPTAADDAANHGLKKRYKFTKGSSEVDMIGPIHSDIFFQDKHMLNGVDLKLKLIRSSNAFCLMTAGANPAYKVVILNASVFVRKVKVSSAVMLGHMKALEKGTAKYPIKRNLCKMVSVPRGNLTLTQDHVFLGQLPNRIMVGCVTNEAFNGRYGKNPFNFQHMDINFLTVHVDGEQIPYSPLKPKFKAPGKNFIRAYQTLFSGTDKMYQDEGITITRDDYPAGYTLFAFDLSPDLSVAGHFNLVRRGNLRLDVHFANPLEATINVIIYAEFNNIIEIDQARNVIFDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8H0</accession>
    <name>A0A913Z8H0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048037.1">
        <property type="nucleotide sequence ID" value="XM_038192109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z8H0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192109.1">
        <property type="protein sequence ID" value="XP_038048037.1"/>
        <property type="gene ID" value="LOC119722090"/>
    </dbReference>
    <dbReference type="GeneID" id="119722090"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF18">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038054245" evidence="4">
        <location>
            <begin position="22"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase N-terminal" evidence="6">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="5">
        <location>
            <begin position="405"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="7">
        <location>
            <begin position="641"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="737" mass="81660" checksum="EF5C6B9734D3295F" modified="2023-02-22" version="1">MKEKLLVLWICVTAGLLCVTASPMASGPEGVGVVSQRGSRVRRQSEGDVRNCDLDPPYYPSTVTNTTVQVANLRREMVANGIAAYVVPSEDAHGSEYVASRDKRRAFLSGLMGSAGLAIVTATEAKLWTDGRYFLQVKKEMDCQWDLMRVGATFDDPSPEDWLADNLNNMDMIGFDPALMSVSDYEDYEAALKTKMPDKTITMKSIQVNLIDNIWDDQPPYNPKTVITVLDAAKYTGETWQQKVIDGAPGQNSTRWEMGQVKGETIDAFVITKLDEIAWLFNLRGDDVPYNPMFVSYAIVTKTDTMLYLYDSASSVRVPAAVKTHLNVNAAGSTCLNSNPCVIVKDYPVFFDDLRGFNESLANKIWISDQASYAVYESISDAKRYVAASPLLLMKAVKSDMEAQGMEEAHTMDSVALCNIGAWMQEKIDGLKDPMTGDKTVISEQIVMDKCIEERAKFADNRGLSFGTIAGMGPHGAIIHYTSTPETDVPITKDGTFLLDSGGQYLQGTCDITRTFHFGTPTAFMKEAYTRVLLGSFDLAMSVFRTGIYGRDIDSIARNQLWSGGLDYNHGTGHGIGHFLNVHEGPAVIKVGVRAGEKPLDLNMFQSDEPGYYEDGSFGIRIENVVRTVPADVAHQFEGYQYMTFKMISLVPYEPSLIDFGMFNNKQLEYYNTYNKMVRDKIGDHSMLSEAGKAWMMSKTAPVEYTFELSTSSGQRTAPSLVAILVTMILSTLYSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z8S2</accession>
    <name>A0A913Z8S2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrator complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048193.1">
        <property type="nucleotide sequence ID" value="XM_038192265.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038192265.1">
        <property type="protein sequence ID" value="XP_038048193.1"/>
        <property type="gene ID" value="LOC119722216"/>
    </dbReference>
    <dbReference type="GeneID" id="119722216"/>
    <dbReference type="OMA" id="CSEFRFY"/>
    <dbReference type="OrthoDB" id="19938at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053964">
        <property type="entry name" value="INT1_R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053966">
        <property type="entry name" value="INTS1_INTS2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053965">
        <property type="entry name" value="INTS1_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="308"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="3">
        <location>
            <begin position="1828"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="4">
        <location>
            <begin position="2057"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1706"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1541"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2204" mass="245157" checksum="2D2A37BC9B7C6C60" modified="2023-02-22" version="1">MERNKQLGKKLPGRRILPAGEIIALGAKSRPGGGQDGSELRANPEWKREAPTTSAGPPHKIAKVSGQTFTPLGRGVPESSKGGAGEHVIKPGIKTIEVPASELLDQVLDADGAEDDDRIDGLLCGALKTLKSTRAKPGSQLYLSLMYLAKIKPMLFESEDVVDYVCSLLKRDISLSFKSKGNPLVSVLACNLLMHAYLYEDNWPIAFVKVFLEDAMGERVWVDHPSCREFCSNIQTAFGTKMPPRHLMLPIDQLRHSTSTPDLQSGSPLRDDSDLSSESAANQTSEDMDLTADVQAEGVTARYSLLKDSIETYVVDFVRDQLTRRQGMDTPRNLLRVLTAACGFPEVRLLAATRLEMWLQNPKLTRPAQELLMAVCLNCDTHGQEDVEVIGHLIKIRLKTKPLINHYMLSMKELLNQHSDNLSTLLKHTIYNELSNSRNPNNMPLLATIFQHSPEASAKFLANVFQDLLMNRDDYLRAVRALFREIVKSLRYDLDFPAFCRGLMKERTDKQFIDMEAQFKDRMLLSLTDLIVLAALLSVSPAIKEAVAAYTRGDRKDMDVLRAFQNQASVMQRDAVWWLHTVAPKMFKVNQQDFNQCLQKVLFMEPSESYCSKDNWPPESDRSLLLSLLSEVPVQEDTLMRVLVMGLSRELPLTAADGLELADKLVKRAAVLYAEDFPVLKVERIQLIDAVLNLCAYHHPENIQLPQGYSPPSLAISNLYWKGWILLVVITAFNPTNIGLSAWERYPMLRCFMEMVMTNNFKYPPPTAAPDERSQEEVRTRELQVIALEKQEILEFENHLARVAITEANSLLLSQVIRMDPNGIARRPPAQVLEQLQHFNKVLNLGHMLCRSRSPDFLLDIIQRQGTSQSMPWLAELVNSAEGSLDVLPVQCLCEFLLNDNQDSDAGEESKKGDAKRKQRIDKQEQLLSRLQTLVRGPDSQASTCCEVMDYFLRRLSSQQQASRSLAAKGLMMVLSVPEDKNTMEEDMETEDPPWACPTLMASHEWLLKNMPSLPHFDPVRASATTALRQACQIETDPLALSAYVVFLSQFAPVSDLNDLAVDLAQLIVERPTIVSCILPRETYNEVADVTLAAMIKIFSRYLLKATKPNEEGYSWSDTQDQVFLYWQTGESATMHILIVHAMVILLTYGQPKVDSDFQLLLHSWFPENSTPPQAYLVDTSEDALLLPDWLKLRMIRSSVPELVIAALQDLEPAQLVLFIQSFGIPTASMSQLLAHLDAAVVQDSQAMENAVVDKAYMAQLVEVQQMRGASGGVEFHKLLTEGVEEPSDKDKDKVESKKEESVEKMDTSESAMRLPDEDHQEEWCKLLIKLFENEPSEESRQVFAIVQQEILKDIRRLRTDPLHKPSEMLTSSLLSIVKDGSLLLSQLTMRADIGSPLLSLLLTREKLQQKYGSPSTFPELVQYLCEALPTKEGTLAQTLIHCQKELSVSSVDVNVDQALKEMTGDSQGNKQESMEKVVKAFRHGQAPANDELLEQVCKQLLDSNANQMEKLLTTSLTASHGRRAPSQASQRVGMLSRLLTHQQQKHSSTSGTQTSSHPQLLASTSGLLTDWLALLDPEACQACPDLQQQAIFAPAPPGNRNSPISSGDSQKRIGSAYLLALLTHQANWGTLHRCIDRLLGPARNAYSFSATAVLDFLWACIHIPKIWQGRDTRASKRHSEEDVLCLSPDQICALADYIIQEAADSSGQYGAPPSATPNAPPIAPPSAPPIAPPSAPPDADEGLTELASNTIKARLSLLLTSFHGNKGVAEHLIRYLGDCSRETNPSSALYQQLLLELYLQVPETIQNLSFISTKLQSQDTSNIPTPVDCLTHRLLCVLADSKPGDTSKQKADDANVACRKLAAEHPVLILRQLAMVTVLLQGRTHLNFKEFRVRGHLRFFNHILGILQLLEPQLFAQPSTVLHGIMEAYFPILPHSVIAKKPLESIITKFIQLLYQYSSHNPTQAQPLLEKHSTALNNLSQVYPDIQQLKSLLASITLTSSSKDQSGLGSAPNQAEQAMDEIPGVGGREETYSPTLAAMMGADASWDTEDVKSFAERLSQEEDSEGMAEALNELEEKSSSAVGILQNFVTELSTQMTSCNKDCRQTAFVLVIRYIRHDPSVASKFLPAYMECLNSMDQEVVQTALKNLPEFTLLCQENAEVVLQKAFTVGVNSKLSTVPLIAETLKLLSMDSASTTSNTTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z909</accession>
    <name>A0A913Z909_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038048232.1">
        <property type="nucleotide sequence ID" value="XM_038192304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z909"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192304.1">
        <property type="protein sequence ID" value="XP_038048232.1"/>
        <property type="gene ID" value="LOC119722262"/>
    </dbReference>
    <dbReference type="GeneID" id="119722262"/>
    <dbReference type="OrthoDB" id="10499932at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="309" mass="33576" checksum="A962788C90E5CF26" modified="2023-02-22" version="1">MTFAADIITVRLFVTLVTFLDCVLKNSVLKESKLKATLQGPSCRYPPRQTCLPQPLDGQDKYNIPSGALLNFSCSRTDSAPAGADLYGLDRVHCDDGWFQPANFPVCFDRCQINEQNLTSAGLNISGGQVAEGNTLRSGDSYTVHCSAVDETLWGHATIYCMDGEFVPSVLPVCCRDGGTVDKEQPSDTVSMVTFVAVVAPTGVAAALLFIALVAVWRKTPPRSEERSKERQNSREVMIVNTAFASDRSPSTSIPPNVPERPSNSYFSSAGVSESYLTPTVKDPPTDSKGSIYDYIDPKSTDYYLELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z938</accession>
    <name>A0A913Z938_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(S)-3-amino-2-methylpropionate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
            <ecNumber evidence="3">2.6.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-AIBAT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EC" id="2.6.1.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038048298.1">
        <property type="nucleotide sequence ID" value="XM_038192370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z938"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192370.1">
        <property type="protein sequence ID" value="XP_038048298.1"/>
        <property type="gene ID" value="LOC119722322"/>
    </dbReference>
    <dbReference type="GeneID" id="119722322"/>
    <dbReference type="OMA" id="ERIMTTW"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047298">
        <property type="term" value="F:(S)-3-amino-2-methylpropionate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000073">
        <property type="entry name" value="Probable 4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="504" mass="55503" checksum="FD8DE0BDF494C6DE" modified="2023-02-22" version="1">MAWIQRLRLSRIYPSSWTGCFHGSVCRGLSVTSANAAVQKLVPNEYDGPSVKTPIPGPRSQELIAKLDAITKNSGTVQYFVDFKASLGNYLVDVDGNRLLDLFMQISSIPIGYNHPAVIDVLKSSDNLHAMVNRPALGVFPGETFPDMLDQAFMQCAPKGLTKVQPMMCGACSNENAIKQAFLTYRRKKRGGPATQEEMDSCVTGKEPGCPPYTVLSFTGSFHGRTLGCLSMTNSKPIFRLDFPSLGWPVAPFPRLNYPLEDFVSENKAEESRCLQEVIRSIEENKVRGRDVAAVIVEPIQGEGGDNLASADFFRQLQAICKEHGVALVLDEVQTGCGTSGHFWAHEAWGLPEPPDFVTFSKKMLSGGYYFKDEFAVDAPSRIFNTWMGDPPKLLMLGAIIKVIQEMDLVGQARESGQYMMDGIKDLQARYPQHLSRARGMGTHIAVDGKDTESAAKIASLVREKGVIMGLSGKQSIRFRPALVFQPHHADICLERFDDVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z9J9</accession>
    <name>A0A913Z9J9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038047686.1">
        <property type="nucleotide sequence ID" value="XM_038191758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z9J9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191758.1">
        <property type="protein sequence ID" value="XP_038047686.1"/>
        <property type="gene ID" value="LOC119721801"/>
    </dbReference>
    <dbReference type="GeneID" id="119721801"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="21823" checksum="D82A91DD49523376" modified="2023-02-22" version="1">MAGHDHKPVRHNHPGEPTKGKGEEFLHRTQTSLCIHAQSDPGQKSSDLIRLLRNPSFLVLMAVSIAHGFGWASTTYHLVSRAESINIEPDNAALLLTLMGAGSLIGRLSIGWIVDRNWMRPELYYTLSFGVCALATFITPLITEFKVLVAVALVHGISNGVASVVITMTPRLVVKPSLASTSMAYFFLAWALVKYLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB01</accession>
    <name>A0A913ZB01_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048958.1">
        <property type="nucleotide sequence ID" value="XM_038193030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZB01"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193030.1">
        <property type="protein sequence ID" value="XP_038048958.1"/>
        <property type="gene ID" value="LOC119722736"/>
    </dbReference>
    <dbReference type="GeneID" id="119722736"/>
    <dbReference type="OMA" id="WSAEMIH"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="86"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="41840" checksum="8BF16EEFCCC83B83" modified="2023-02-22" version="1">MASSPTKTSTLKKEKKDESFLEKVTTLGRRKKIKDLKEVNDLNIDGKNALEAPTSPVELTPDNFVLENGEERSMIEPDSREDAKLKELIQVLMDWINEEMKEQRVIVRDLEEDLYDGQILGNLIEKLAGIRLEVREVMQSEVFQKQKLQVVLDTVNKIMNLPRWNQQKWSVDGIHSKNLIAILHLLVALAFHFKAPIRIPEYVSAKVVVVQKKDNLLVTNRVTEEITTTNEAIGGRFERDAFDTLFDHAPDKLNVVKKSLISFANKHLNKINLEVTDLDNQFHDGVYFILLMGLLEGYYVPLYHYHVTPTLFEEKVHNVSFALDLMDDAGLPKAKARAEDVVNLDLKSTMRVLYNIFTKYKHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBK6</accession>
    <name>A0A913ZBK6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048270.1">
        <property type="nucleotide sequence ID" value="XM_038192342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBK6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192342.1">
        <property type="protein sequence ID" value="XP_038048270.1"/>
        <property type="gene ID" value="LOC119722295"/>
    </dbReference>
    <dbReference type="GeneID" id="119722295"/>
    <dbReference type="OMA" id="CKDERRY"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="539" mass="58556" checksum="209F57271830ABF2" modified="2023-02-22" version="1">MEQTHAVKLYVYDLTKGLAAQMSMPLLGKHLDGVWHTSVVVFGREYFYGGGGIESCKPSGTILGQPNQVHEMGTTQVDYTIWLEYMGGLGCDEFSGERYNLFEHNCNTFSNEACQFLTGNSIPTFILNLPHEVMNTPIGAMMKGLIESLSSNPTGRVGGPTHRPIYDPVPLPNYPDPPPAKPSEVKPASESAAKPEQAQKSEPQASTSDAQATASSEAAATNKGADSGHAQSSGATADVGSPVKDSSRVNLYYDSDDEYIDSLRQSAPPEPLRLKVFSGVDVTACVETIKKEMPEGVLTREEMELLMELKDCLRLEFLLEEPPSPVKSETFLVIGKLLNLAIGGIPSEVLHPLVDLLSMAFLSQDVIHTLCNNEDQTVMTFVSSSDCHPLQIQISVFRMLCNICTAYSGKHWLTQVRHWTLEDGSPQCNRDIVSRLVVSAILSGSDELCCAASALVYNLTRYTVSDDNAVEFSSALLQSLTSEAISEETAYYSLLALYGLMKCGEVMCLATVMGLDTARYAKISDRLGKLCADIDSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBN9</accession>
    <name>A0A913ZBN9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038049197.1">
        <property type="nucleotide sequence ID" value="XM_038193269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193269.1">
        <property type="protein sequence ID" value="XP_038049197.1"/>
        <property type="gene ID" value="LOC119722872"/>
    </dbReference>
    <dbReference type="GeneID" id="119722872"/>
    <dbReference type="CTD" id="55131"/>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12415">
        <property type="entry name" value="RRM3_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="266"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="421"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="690" mass="78090" checksum="97C9F7BB56AABBC1" modified="2023-02-22" version="1">MKTKLSLGKRKLFLSYSRKKAPRKKEKATAEQDEEDKVDKSPPERRLGSAKLDRKQGTVKGEAKDKEGRLIIRNLAFSCSEERLAKAFARFGDITEVHIPSDPTDPSKVRGYGFVQFDSLDSASKAVKEMNAKKIMGRPIAVDWSLSRDRYLAAAKTVPAGKQKPKDTDEEEKSDDEEDDESDDESGVESSSEVEETRDDDEDDSDDSPDSDDDDDEEEMEEDTSSEDEGMASNEDGKRKRTHKNTEQESNIAKRKKLSNDVGEGRTVFIRNILFETTEEEIHEFFSEFGQIMYCKLVVDKATEHSKGTAFVQFATTENAERCLEKASKEGDEGLVLGGRQLLVSLALPREQASKLREVKKEKQKILKKDKRNMYLLQEGFIRPGTSAAQGMTDADIAKRTKLESVKRLKLKNINIFVSPTRLAIHNLPKAVDGKKLNQALLIAAGDKKAKVIESRVMVDMKSPNAEGRGKSLGFAFAEFTKHEHALAALRKMNNSTEFFGGSKRPIVGFSLENRQALEAKQRRKERSLLKTRQIQSMQKPKDNKSKQKDGESQQPTPKSKPQPKTKKGVLPPPPSTKLEKRMQSKSKMTVHVGAKKRWRDRGKEQEAQKEKRKMRRRQLLGEVGRKQRESAKPRAKKLQAEDGTQKSRRQKGSSEDAKFDKLVANYKQKLFSRETAGQTLKKSKWFDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBS1</accession>
    <name>A0A913ZBS1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049014.1">
        <property type="nucleotide sequence ID" value="XM_038193086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193086.1">
        <property type="protein sequence ID" value="XP_038049014.1"/>
        <property type="gene ID" value="LOC119722776"/>
    </dbReference>
    <dbReference type="GeneID" id="119722776"/>
    <dbReference type="OMA" id="DAIWPFF"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="209" mass="22830" checksum="F363F5C0FB20CF00" modified="2023-02-22" version="1">MAAPMNLATAAASGNINLVRSLVAQGADVNQRSSDGFTPLCNAAFWGYSDIVEYLLRHGGDVNQSNSGTRWTASHCAAFQGHGKVLMKLMESKPDLAMRDNRGRTAVDFASALEIIWPFFAAEGCKRTPKAELIRLEIVHKVKDYDPSIPQTDLAHFSRPGSAYAMRSQSLRGDGNKHKTYAAQMGDVLAEEDEGVGKPQDPSFNIWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCV9</accession>
    <name>A0A913ZCV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049339.1">
        <property type="nucleotide sequence ID" value="XM_038193411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049346.1">
        <property type="nucleotide sequence ID" value="XM_038193418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049354.1">
        <property type="nucleotide sequence ID" value="XM_038193426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049364.1">
        <property type="nucleotide sequence ID" value="XM_038193436.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193411.1">
        <property type="protein sequence ID" value="XP_038049339.1"/>
        <property type="gene ID" value="LOC119722973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193418.1">
        <property type="protein sequence ID" value="XP_038049346.1"/>
        <property type="gene ID" value="LOC119722973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193426.1">
        <property type="protein sequence ID" value="XP_038049354.1"/>
        <property type="gene ID" value="LOC119722973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193436.1">
        <property type="protein sequence ID" value="XP_038049364.1"/>
        <property type="gene ID" value="LOC119722973"/>
    </dbReference>
    <dbReference type="GeneID" id="119722973"/>
    <dbReference type="CTD" id="8567"/>
    <dbReference type="OMA" id="TKILCLW"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000002">
        <property type="entry name" value="MAP kinase-activating death domain protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056574">
        <property type="entry name" value="Death_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23629">
        <property type="entry name" value="Death_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="18"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="742"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1607" mass="178813" checksum="84F0EE8C5A144DE2" modified="2023-02-22" version="1">MEGFQAGKKYFSPRLLDYILIVGSRHPYSNNNVAQTPEMLRRYPQDDHPDFPLPQDVVFFCQPEGCLTVGQKKLSLRENTSFVFTLTDKDSGRARYGICVNFYRPFKSSDRKMEHQNEKALHNDRENSNRNGTLSVPSDEGQRKRSPRTRRKLKQAKKVRNNSLTSLCILSHHPFISTFRECLFILKRLIDSCNDRTCSRKVGGSKGSLRDCVWGVLTGICSDIPPLVRHDVRQIETWILRFLSAPVPVPGKTRVEIQVLDTQPPMVFALPDHTRFSLADFPLHLPLELLGVDTCLRVLTLIMLENKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMGSAEQLLLAPTPFIIGVPASFFLYKPYFKLPEDVWLIDLDTNKITFCGRYEEVPVLPEPEGSVLKKHFKQALTSMSLSPPPIKDFEQSRGEVEAISRRRETFSDETGFNPFIYGNDVDSVDVATRVAMVKFFNSPNVMAHHNEHTRTLRLHPRPVVAFQVHSFLQSRSVLTTFCERLASTQAVEFFGEYCLNPTNVTFLRIHTGVYDPQLIGDKAKWFLEQLQPINFKVQFDNCTLGIPVNSGTEAWSDSSNPTDESGEESDGGSSSSSSYSSLNDFVTDMMNSDIQGDVLADDEETSGLRSQVDETSIYHPPDTLQIPADMSQSDSAYSFPETDSSSSQDTTSPESSDGEELCIASGWRSKTGQDMEADSDADADSIQYDSDTSAQVTRLNLKHKPAAAGTVSSSNAPDSPSLDADVRRRGSGKDERSSPTFLEKVNALFRSDSSDSSTPPTPTRKKPSLLKNIMDLALETTSSKEPVGSPTSIASTDAHEYSPSVRSDPGPYRGSSAAHANTMGLPLRKKKPTSPFPRDTRRSLVERSSLIKHSSTKKPDKDRKRLSISEDRPNSKNDRSMKTLIDDQLFIKEITRGVLEGNNVGWLNWSRLKKLMQSENMRAQVISQLSPQENTTVLDDYIEDTQVSKAVYKGIVSVLKAVIAGLEYSFYTQPIGGFASAYALLEIAHTHYFGKEPDKGKKAHLHGDGIRSESAYAIEGSVVVTPDEQHGGSMAAIPETHSLNEDNFIAAIESWEKRGSVVSSSSTSTEEGAIRVNSPLVEDNRNDSAYELIDMSEVSVGGSTGAGVHGAVGIAAGVAVTGAIGSKVDVEYPGEHSDNKTLHSEDEHAPCIKDMVNNNNSSSIDEGITFQAKKDDTDVIPDNSKSMEPREIIERREKFSEKISSLDSELSEASTLVSYNSTDTLGNESDSSSTCGDGRVRRTRITHQSIRSVMSDSEVELNGLSSFSGRHRSPTTWSSKSCVSAGFRYHGGNMIATDTDASELLLRHYVFEALIAAKDRSPLWDQVQFWEDSFLDSVAAERDAVGMDQGPAEMIHRYDSLTPSEKKRLEEDEDKLLADMLSNAIAFMIMMKLPKPEVKRKVRRLLGRSHIGLVYSQEVNDLLDQINNLHGNDIDLKPSGSKRMRKHSFVVHAGTDTKGDVLFMEVCDDCVIIRSGSGAVCDRCWYERLINMTYCPKTKVLCLSRRLTSTTRLDKYYTKKCRELYFCIKESMEKAATRQKNGISGGKSSKRTCDLLIVLYLSNQKPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZF83</accession>
    <name>A0A913ZF83_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038049630.1">
        <property type="nucleotide sequence ID" value="XM_038193702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZF83"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193702.1">
        <property type="protein sequence ID" value="XP_038049630.1"/>
        <property type="gene ID" value="LOC119723152"/>
    </dbReference>
    <dbReference type="GeneID" id="119723152"/>
    <dbReference type="OMA" id="PDAEYEF"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="164"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="362"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="526" mass="57336" checksum="F6BD6E1E50E460BC" modified="2023-02-22" version="1">MYPPLFPTLSTRLDYLERKMSAVGLSPLLLFVLCLHLEGSNAFESVHLSATPVKGDPYALNLTWTYPSQGRLIQEHGKPKYFSISFALENRYGCHTVPNATQYGNRQMVEMIRRGGTHDAGRYTLTGLEPNSMYFIYIQGFTLSFNFPESSTYARTGQKSPVDAPTGVRLIRNESTTTSLKFAWDRVPCTSGSRSSPFLAYRYSLISDENPTGSSLETTSAEALVAGLEPYTRYGFRVQFKSEEGYGPFSEPYYAITMGQVSLTQETEVAAGETVELVCRSRGSSSSGIPGPDHLILGGPEGKGQRSSTMVSGLTRINHFRAVVDEPNVEFTCTLHYDGVDEALGTDSLRVKVYEKPYVQTVPMVRIGVPSPGNATVTWLPWTADGGGDGPVDDQEVVWRRAGDLEYDNMAVEPSSVSAVVRGLDPDAEYEFAVVLFRKGIPGPPNKAMLIEGTTTPAMPDGPSEKSSQNEGGYHNLFGPETDNAIIAGVCGIFLVILILLSVIGVWCTSTKTPSDDKVPLTKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFH3</accession>
    <name>A0A913ZFH3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049720.1">
        <property type="nucleotide sequence ID" value="XM_038193792.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193792.1">
        <property type="protein sequence ID" value="XP_038049720.1"/>
        <property type="gene ID" value="LOC119723229"/>
    </dbReference>
    <dbReference type="GeneID" id="119723229"/>
    <dbReference type="OrthoDB" id="10021323at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF13">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="10">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="10">
        <location>
            <begin position="794"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="907"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1180"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1246"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="9">
        <location>
            <begin position="1457"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="869"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1415"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1684"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1711"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1722"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1749"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1760"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1787"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1798"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1825"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1836"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1874"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1910"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1934"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1976" mass="217454" checksum="D626CD60BA61D25D" modified="2023-02-22" version="1">MKLFDEKNDGLLKLSKNVLTTCVLSHTTDLTEILFGQLTARFNEKVFITDKGYCYDWTLRPWPTSGKVCFQVKSEGIAALALSPERDPPAGTLVYEMELGFSNNQLTVLRRGMHGGNIAVESTPDILDCDEFRTFCLEASGPHITLTALGDPKPILDYVDEERPEVMYQYIGFAGGYDFKVWWRWPEDMVPDYEIPKDGQEIINLPPQPPVGADKCLETSPPCGDNGVCYEDHSLSSGFRCECTNNYRGERCDEKPSGSNPEEPAKPPPRPQDPCRPNNPCKNGGVCSSTGVSKYTCACVNGYSGDNCEQEPDPCQPNNPCLNDGVCRSIGGGQYTCECVNGYMGDNCEEEPDPCQPNNPCQNGGICKSTGGEQYTCQCVNGYTGAFCEEEPDPCRPNNPCKNGGVCSSTGVSKYTCACVNGYSGDNCEQEPGSIIVITEDIEETDFPSIPPLTPDGLYEICIRVNPEEAVFVGIYKSRADADQNLAMYDLTFESGEPATVKSQGQPVGAEVSWSGSLSFCIEISDQISVYPKEPGALPWWTLPKPDDVKHIEIGFASSITTTWTIIPTYKPPSGSEPEVPEPKPERPKEPPSGSEPEVPEPIPERPKVCPVLDCLFPCPKGLKKDENGCDTCECKGKVDNRRKCPAVPGGVARICEERCAADNNCEKQHKCCSNGCGHVCIKACKPLKCKKACELGYVRNRKGCEICKCREPFQERPIPDKAPPQEPPAGSEPEVPEPKPERPKEPPAGSEPEVPEPIPERPNVCPQVRCAYPCPKGFKKDENGCGTCECKGKVDHRGKCPAVPMDVAGICEERCAADNNCEKQHKCCSNGCGHICIKACRSLKCKKACELGFKTNQKGCKICQCKEPPAGSEPVVPEPKPERPKEPPAGSEPEVPEPKPERPKECKPFKCKKACKFGYKTNKRGCKICRCEEPPAGSEPEVPEPKPERPRECKPFKCKKACQFGYKTNKRGCKICRCEEPPAGSEPEVPEPKPERPKEPPAGSEPEVPEPKPERPKECKPFKCKKACKFGYKTNKRGCKICRCEEPPAGSEPEVPEPIPERPKECKPFKCKKACQFGYKTNKRGCKICRCEEPPAGSEPEVPEPKPERPKEPPAGSEPEVPEPKPERPKECKPFKCKKACQFGYKTNKRGCKICRCEEPPAGSEPEVPEPKPERPKECKPFKCKKACQFGYKTNKRGCKICRCEEPPAGSEPEVPEPKPERPKEPPAGSAPEVPEPKPERPKACPEPECDVDCADGFEMDAEGCQTCDCVYIPEEVEGEQQPEDVYGTVLTTTGGTKEIVISTEVDTTQEQEFTIDLSDPVEFLLVSTEGTLGIVVVKNYVEIVTSSGKTLKSVKLPSWCLRQPELTFSVSFFTTGFKLLIITTSGEERVLTKYVKSNKRKFSCRALKVRSKGTKKCKVKYRHKRRKGKRGKRGKKGKKEKNRPKKNRPKKKKGCPEVQCAEACEEGFEMDVEGCQTCDCIEIQQGGEGGQPEDEFGTVLQTTGGSKEIVISTEVDTTQEQEFTIDRNDPVEFLLTSSEGELGIVVIKSSVEIVSSSGKTLKSVKLPSWCLVQQELTFSVSFFTTGFKLLIITTSGEERVLTKYVKSNKKKFSCRALKMRSKGTKKCKVKYRHKRRRGRRGKGGNKGKKGNRSVKKKSKGKGGKTKSGSKSRSKSAKENKGPKKSKTKGNRSLKKSKGKGGKTRSRSKSRSESAKENKGPKKSKTKGNRSLKKSKGKGGKTRSRSKSRSESAKENKGPKKSKTKGNRSLKKHKGKGGKTRSRSKSRSESAKENKGPKKSKTKGNRSLKKSKGKGGKTRSRSKSRSESAKENKGPKKSKTKGNRSLKKHKGKGGKTRSRSKSRSQSTKENKGPKKSKTKGNRSLKKSKGKGGKTRSRSKSRSESAKGNRSPKKSKGKGRKTKSRSKSDEGNRSPKKSKTKGNKSPKKSKTKGNKSPKKPKTKGNKSPKKSKTKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZFW8</accession>
    <name>A0A913ZFW8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THAP4-like heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_038049885.1">
        <property type="nucleotide sequence ID" value="XM_038193957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZFW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193957.1">
        <property type="protein sequence ID" value="XP_038049885.1"/>
        <property type="gene ID" value="LOC119723355"/>
    </dbReference>
    <dbReference type="GeneID" id="119723355"/>
    <dbReference type="OMA" id="AFAWDMN"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="25131" checksum="BDE5B6E2CEFE8761" modified="2023-02-22" version="1">MFRTICTFARFVRIPTSTLLRQGGVKCWSIGGASSFTRGFCDKNHGGIPPCKNQGQAKMVEVHEGVRPLTWLLGQWESIEAKGSYPNTNSFNYTETLKVTHLGQPVLNFYSETWLEGLPFHDETGFIKMKQGTSRVAYICAQNIGLVEIEEGELDGTSIEFIPEEPSVLRTSFGTKALGATALKRTFRLDSEGILEQIVYMSTFKVPMTKHLHVKYKKRDTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGU8</accession>
    <name>A0A913ZGU8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LAMP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038050644.1">
        <property type="nucleotide sequence ID" value="XM_038194716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGU8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194716.1">
        <property type="protein sequence ID" value="XP_038050644.1"/>
        <property type="gene ID" value="LOC119723836"/>
    </dbReference>
    <dbReference type="GeneID" id="119723836"/>
    <dbReference type="OMA" id="ISYYNTA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="22">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="320" mass="34538" checksum="837A05C1C656AFE7" modified="2023-02-22" version="1">MTGFCLAAADVATTTPTTTGTQVTDNAMTTVPPSLVTTVPVDTTKAIKATTGNSMLPTNATLTSTAITSAAPDITSPIATTMPTTAPATTPPPSRDNNWNVTGKNGLMCQSMQFCANVTVPYYNTSNLPDSVTVSVPSSSNANGTCSMKEREFILDFIPDGGNETWTLKFVFTANTSSYQLTSLNVKFSYEDVFFNTKKRGQQSSTYISMDGPLAGLTAPLGCPCERDTVLIQSTDKQQLHAVFSDLNIQPFYDKEHPKICQPPKTPSDSPSNVWRSVGVAFIIMFVVLLLASALYCFYVKKKKTTYTGDQIDLVDPDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGZ3</accession>
    <name>A0A913ZGZ3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:70283"/>
            <dbReference type="ChEBI" id="CHEBI:7386"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58263"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:70284"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17169"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225238"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59425"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_038050315.1">
        <property type="nucleotide sequence ID" value="XM_038194387.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050316.1">
        <property type="nucleotide sequence ID" value="XM_038194388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZGZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194387.1">
        <property type="protein sequence ID" value="XP_038050315.1"/>
        <property type="gene ID" value="LOC119723636"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038194388.1">
        <property type="protein sequence ID" value="XP_038050316.1"/>
        <property type="gene ID" value="LOC119723636"/>
    </dbReference>
    <dbReference type="GeneID" id="119723636"/>
    <dbReference type="OMA" id="PIHWAGT"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="522" mass="58541" checksum="6DD1E5AD2D745A88" modified="2023-02-22" version="1">MTSSKKDVIIIGGGISGMSAAKLLQEQGLDVLVVEARDRLGGRTFTQVDSTVGYVDLGGSYVGPTQNRLLRMAKELGVENYKIQEVERLVWVDNQKCYPFTGTWPRFWNPLVNIDLNNAIREIDRLGDMIPVDAPWDAPNAEELDSMTMKEWIDKTCWTESTRRFLTMCCSFMLAAEPAELSCLFYCFHAKKAAIHVLHHQGPAEDGAEERKFVGGSQQLSIKMGERVGKDNIKLESPVSKIEQSEEKVVVQTINGDVFEAKYVIMAMAPSMTQRIHYSPPLPPRRNQLIARAPVGSVIKCMVYYDRQWWKDRDFCGSTFNVDPASPMVYSLDDTKPDGSFPALICFVAANKAREFCGISKEERRDRLCKAYFNAFNGAEEALHPVNYVEKNWMAEQYSGGCYTATYGPGVLTQLGKELRKPFGRLYFAGTETATHWAGYMEGGIQAGERACREVLHRMGKIAENEVWQDEPESKDVPALPFESTFFERNAPSVPGLLKFLARTAIASTAAGLLIAWRLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHG0</accession>
    <name>A0A913ZHG0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 63</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051222.1">
        <property type="nucleotide sequence ID" value="XM_038195294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHG0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195294.1">
        <property type="protein sequence ID" value="XP_038051222.1"/>
        <property type="gene ID" value="LOC119724305"/>
    </dbReference>
    <dbReference type="GeneID" id="119724305"/>
    <dbReference type="OMA" id="FWKENTR"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71966" checksum="DA1FA0402804C878" modified="2023-02-22" version="1">MPSHKHSSGKLLRRPLAPLTPPATQPSGSIIGPSKKTQNGKHQSRSLPSLSSLSQEDEEDDFEEELAFPVRNFSPVPSVIPSLASDFQEAQRAPQNTPKIPLKPSPQTRRSHSGPVNSPRVPLSRTDLRFVLDSRYKPKGTSADTFRPRSLVQPYKPRGPDGFPFRTPRNLPEVKKELLYLDHEHLRYHLPPDFTLEDFQVEVGAYGRPLQRETLKKAILSKQNYKKLTTLFASFVEEPVQEKVNTVELKGEEIPEVVPRVPQHQLLIEMASIIHQQMRNMINEEMIGSLPGQETEQSALTSALMTPALAALAYQQAETASGNLAVFSRQAESTNEVMFNMPVSKYFQGSRRSNSPFNEQDSSQITPSELAILDCLVNGGLALSLKAHFILAMPEITPLTKTLTYLNLSFNDFRVFPSEVLTLRSLEVLKLRNNPLKELPFDIHRLSKLRTLVVSFNLITSLPPSLFTLPLQFLDLSYNKLTFLPSEIRHLRSTLRELNVEGNQLPALPCSALKLRKLRYLRVTNNFMHPLFWKENSQNEPQRLLDLSSLAVKQSGLDIFRPSLLPDSLHSVLNRYSRCDCCQGPLYGPGLRIIRPCSKAFGVRKLPFIFTSCSPYCRDTFLTSVESLTQMLYMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZIQ0</accession>
    <name>A0A913ZIQ0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051249.1">
        <property type="nucleotide sequence ID" value="XM_038195321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZIQ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195321.1">
        <property type="protein sequence ID" value="XP_038051249.1"/>
        <property type="gene ID" value="LOC119724327"/>
    </dbReference>
    <dbReference type="GeneID" id="119724327"/>
    <dbReference type="OMA" id="GGRHPCT"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000581">
        <property type="entry name" value="Ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="13">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="12">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="258" mass="27989" checksum="F94E5B1C7B8EE1EC" modified="2023-02-22" version="1">MGRVIRGQRKGAGSVFKSHNKHRKGPAKLRSLDYAERHGYIKGIVKDIIHDPGRGAPLAKIAFRDPYRYKKRSELMIAAEGMFTGQFIYCGRKAALTIGNVLPIGSMPEGTIVCALEEKTGDRGKVARASGNYATVIAHNPDTRKTRVKLPSGAKKVVPSANRAMVGIVAGGGRIDKPLLKAGRAYHKYKAKRNCWPRVRGVAMNPVDHPHGGGNHQHIGAPSTVRRDTSAGRKVGLIAARRTGRLRGTKKIPVGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJD1</accession>
    <name>A0A913ZJD1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051170.1">
        <property type="nucleotide sequence ID" value="XM_038195242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJD1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195242.1">
        <property type="protein sequence ID" value="XP_038051170.1"/>
        <property type="gene ID" value="LOC119724269"/>
    </dbReference>
    <dbReference type="GeneID" id="119724269"/>
    <dbReference type="OMA" id="TTIDIAM"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="317" mass="36780" checksum="4DBEC11CF89F96E8" modified="2023-02-22" version="1">MTTIDIAMMSDSDDSQHVYMYKNVTFDPHIVPRGNLTEVERFNVRQDDIFIASYPRSGTHWLTEMVLLIMADGDVSKVNRRTMDQVFEMTLPIDPSRPLRAGYKAVEEWPVGEPRVVLTHLPAELLPLQLWQQKGAKVVYIARNVLDVLASQYQHLSAINLLPPATKDWPKFIQFKLSDKDTYSGRNWFSHVTSYWRRRSSNEKLLFLKYEDIKTDHRKAVRDIAEFLQRPLAAEQIDRVVELTTFDGMMKTYQQIEAEDPSKIFRTRALSVEPFLKKGIVGNWKGKYSDEQLATIKKKVVEHCGSLGLHFEFETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZMD5</accession>
    <name>A0A913ZMD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052509.1">
        <property type="nucleotide sequence ID" value="XM_038196581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052512.1">
        <property type="nucleotide sequence ID" value="XM_038196584.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038052517.1">
        <property type="nucleotide sequence ID" value="XM_038196589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZMD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038196581.1">
        <property type="protein sequence ID" value="XP_038052509.1"/>
        <property type="gene ID" value="LOC119725222"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196584.1">
        <property type="protein sequence ID" value="XP_038052512.1"/>
        <property type="gene ID" value="LOC119725222"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196589.1">
        <property type="protein sequence ID" value="XP_038052517.1"/>
        <property type="gene ID" value="LOC119725222"/>
    </dbReference>
    <dbReference type="GeneID" id="119725222"/>
    <dbReference type="OMA" id="GGACCEN"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF519">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="26295" checksum="EE0E8BA639620BCC" modified="2023-02-22" version="1">MTMEGCGAKCIKFLLFVINFIVALCGLGLIATGLLIKFGAVDFIPIDDVANLLNSQLLRSAVYIIIAAGGFVFLVAVCGCFGALCESKCLLVLYFLLLFIVFAGQIAAGILAALYTRQITDYLTNESRDFLKTNYNNTNTTTNEFATAAWDLIQTKLECCGVEGSADYAGNTFIVNDNLPYPKSCCPSSECSNNVVRSNGCQSAIEKLISDYGTIIGATAVGVAFFELCCMLLAICVCRNVDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNK5</accession>
    <name>A0A913ZNK5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052959.1">
        <property type="nucleotide sequence ID" value="XM_038197031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNK5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197031.1">
        <property type="protein sequence ID" value="XP_038052959.1"/>
        <property type="gene ID" value="LOC119725570"/>
    </dbReference>
    <dbReference type="GeneID" id="119725570"/>
    <dbReference type="CTD" id="84926"/>
    <dbReference type="OMA" id="EMVIDSC"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12908">
        <property type="entry name" value="SPRYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035783">
        <property type="entry name" value="SPRYD3_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="187"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="465" mass="52055" checksum="0CEC957960A6A8EF" modified="2023-02-22" version="1">MDARRPIVPFPFHRMNNRMNKGPPVNMINHPQYGLDSHGPQNLEIKSKRMAVSWRDDTLFYVPDRTGKQGVCILEPSMQPGQEYFEAEIVSTGRWGAIRIGLAPPDHSLEVHLGIEGNSVAFSVDDSAVYGQDQTVTLQCRACKPGDKIGVGIKFGENYMEGADEKCPVVFTLNGKEIHRRDVVIPFKGLCPAVSMASQGQMVRFKARCDWSSQEEEMVIDSCEDDWARLHDVTVHGQILAYAGRGKTIADVGLAQAKKPLSPTNHYFELEIIDPGKNCYIAIGLAKKDYPKKRHPGWNYGSIAYHADDGKIFKGSGVGDSFGPRCHKGDIMGCGIMFPRDYIMDSDEGESDNEEVNSVVKAWPDREPFNRLNQLDRIAQDNFAIDVYDLSEDEYDDYLSEEEEYELQIDGVQQGGKVQVHVFFTRNGTTIGRREVHIPASGFYPTIGMLSLDEKVRVDLRPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZPF1</accession>
    <name>A0A913ZPF1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053249.1">
        <property type="nucleotide sequence ID" value="XM_038197321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZPF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197321.1">
        <property type="protein sequence ID" value="XP_038053249.1"/>
        <property type="gene ID" value="LOC119725761"/>
    </dbReference>
    <dbReference type="GeneID" id="119725761"/>
    <dbReference type="OMA" id="TEYSANC"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037115156" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="111"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="24920" checksum="89EB41C392DD5381" modified="2023-02-22" version="1">MRTVCVTQLVICIILASFAMDASAAEERRTLDEMHAELAQQLLEEEQAGITGEELAAKLRENRRELNEMEREVIEQLLEKELASMTGQELARVLNEVAEDSRSLDTRGAGCTVTEYSANCCAGTSFRVFFKTYNLNACVLAEYLPEQVGVHLRISVSGLNLLDRTVSAENPGDICVGVPEIRVVSLCLNLNNFRVEGGHFRGCFAFKPKAIGFTVATLNMGCIRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZRR8</accession>
    <name>A0A913ZRR8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038053781.1">
        <property type="nucleotide sequence ID" value="XM_038197853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZRR8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197853.1">
        <property type="protein sequence ID" value="XP_038053781.1"/>
        <property type="gene ID" value="LOC119725921"/>
    </dbReference>
    <dbReference type="GeneID" id="119725921"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038053781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="33810" checksum="B5E555875E363890" modified="2023-02-22" version="1">MSGPRLALALLSFDGDTIASIDRVPEYGEDVDRDVRVWSDANGACRCILQSGNEATRLIHLDYKDKIVAAAYSDNTIHIWDTHNGSCMQEIVTDMNKLTSCHLGDGIIIGASKDLIVKIWEPESGKCIKTFHIPPHQGFKFGEKVTYTFSDGLIIVVTSSDALYVVNMKGERVLDVRQDVKPICFTGNKLLTYDVRQGNMMLLPYVRHGRKVLPYVRHGRKVLTYVRHGHQRGYELSIIDPVECVGGKVQGSSKTVSQYIGPTNLMRAWMSDTKLAFQRIGSESEDFETDDEYVSVFYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSD8</accession>
    <name>A0A913ZSD8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054006.1">
        <property type="nucleotide sequence ID" value="XM_038198078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSD8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198078.1">
        <property type="protein sequence ID" value="XP_038054006.1"/>
        <property type="gene ID" value="LOC119726424"/>
    </dbReference>
    <dbReference type="GeneID" id="119726424"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="117" mass="13359" checksum="18CEE503D88386E3" modified="2023-02-22" version="1">MKQPKRPSVDTADTGPVETEAKKKKKLHKDKKHNTTADITQSNEESKPQAKQGDTQGGDDRLAGEGEVKDDRVMTKAHRKGKKRKQQRRVQNDDTVHQSRINAEETQPIKKKKKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSW0</accession>
    <name>A0A913ZSW0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054838.1">
        <property type="nucleotide sequence ID" value="XM_038198910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198910.1">
        <property type="protein sequence ID" value="XP_038054838.1"/>
        <property type="gene ID" value="LOC119727025"/>
    </dbReference>
    <dbReference type="GeneID" id="119727025"/>
    <dbReference type="OMA" id="CICKDEA"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="452" mass="49357" checksum="0689CEAA7BC0803E" modified="2023-02-22" version="1">MMTPTVHTARFLRSLLALVLYSGAFIVGICSAQLDGLTLLPPELQSTAAVDEMRNKLCMSCMDVEQPAPPNVREVLPFCQQICRTDNRILNRQCWEHEAAPCDEGQSPVCSYRDAIVCAYDDGSGSCVYHSEGQSFCICRDESGSWSEEPKESCVPFKPPTTPSSEMCPFGSDPRDDGCLPPPLPTTPGPSTAPGRGVSAGQVNLPAVVLGCVLSVVVLLVIIGVGVWCVLRRRGPSDSSRKNRNAEDSSRMNLNENAPRGTAKPSEQMVPDAHEYAYVDANWRQEPTNPETGEPKPECHTGQENHYYFKVDKVTTEGSDRYVKHGPEGRSSEQTGTTEAPSDPEYFVLEKEDLGDEGREDGSVTSVSPEKEDDGDYLQTTAPPFQNENSGYEVAVLSPVANEDESSQYDRLDRASGKRTNEGVLPGKDNGVYDSLETDDDYNHIARDGQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZT23</accession>
    <name>A0A913ZT23_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038054762.1">
        <property type="nucleotide sequence ID" value="XM_038198834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZT23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198834.1">
        <property type="protein sequence ID" value="XP_038054762.1"/>
        <property type="gene ID" value="LOC119726981"/>
    </dbReference>
    <dbReference type="GeneID" id="119726981"/>
    <dbReference type="OMA" id="EAHGYAN"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="743" mass="84633" checksum="78DA81691C387097" modified="2023-02-22" version="1">MADSSVKNPPPENFKGWLYKWTNYIKGYQRRWFVLSNGLLSYYRNQAEMAHTCRGTINLSGAYIDTEDSCNFVISSGTQTFHLKASSEVERQRWVTSLELAKARAIQMMEEDSDDEEELPSDVDRTELQTTLHILTSKLEDLGICNDLISKHGTALQRALSDLEVIQDPTEAISKLKSINERATLFRITSNAMINACGEYLELAQAQGRKWQKALQYERDQRLRLEDTIETLAKQHNSLEQACREKGRQDHKSVKGTDADDDDEDNEFYDATEDFTSVQLISNVKGHNRTGSDISGNSIASSEGESRPGEPLSTDDLMMQDKHSHKDSSSYWLKPSSIQTGRVRRKTIPTKPTAGLNLWSIIKNCIGKELSKIPVPVNFNEPLSMIQRLGEDLEYAGMLNTAAECKTTLEEMCYVAGFTIGAYASTAVRNTKPFNPLLGETYEFDRSDDLGWRALCEQVSHHPPAAAIHVEAKDWILWTDITIASKFRGKYLQVFPQGIIHIQFRQTGSHYTYRKVTSTVHNIIVGKLWVDQSGECEVVNHTTKECCRINYKPYSYFSGDTPRKVTGVVTDTMGAAKYIISGTWDQKMEYAKVLHTSMDKGSRAKPLYQTAPPKLLWQKNPLPPNAENMYNMTSFCITMNEPEEGIAPTDTRNRPDQRLMEEGLWDDANKEKLRLEEKQRATRRKREAEATAAAEAGKPCDSYKPVWFDRKMDPLTKTITYIYNSRYWDCKEKGEWPECQDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZTA4</accession>
    <name>A0A913ZTA4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054669.1">
        <property type="nucleotide sequence ID" value="XM_038198741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZTA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198741.1">
        <property type="protein sequence ID" value="XP_038054669.1"/>
        <property type="gene ID" value="LOC119726887"/>
    </dbReference>
    <dbReference type="GeneID" id="119726887"/>
    <dbReference type="OMA" id="CCKNAGF"/>
    <dbReference type="OrthoDB" id="4788989at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="358" mass="40499" checksum="3062FA0A7331AFBE" modified="2023-02-22" version="1">MMVVVVPQASVTWRGWSDYRGTAGFRTPSPAVPPAHASRPVVPKPCAPVGCCKNAGFVWEWPVYKSKLREEVPKCDEHPDQNLNVYCNSCEQVICTTCSVLDHEKHSLTGLPEAVEKCKKKVTEMVQKSEKRKTELSTTIEEMSKSRKDLDTMFAYTQKKISKKAQQEITKLKQEVAKIKKEEQKLLKETSTIYKDKLKAFEAVQATNRKELTQTEHKLEEVNQLMNQASCYEILELQQKLLHNLSELSGKQPQQVPDRLTFMDFEEGDRSLGRLILEEEPKAAEKPTPRPPRSCVKEKWELKSEATNIGVTQTYISHVAALFNNKILGCGYPRGITFTSSGDLVVAAGESVQVYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVP8</accession>
    <name>A0A913ZVP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Interacts with Hsc70 as well as DNAJ homologs and Hsp90.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055579.1">
        <property type="nucleotide sequence ID" value="XM_038199651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199651.1">
        <property type="protein sequence ID" value="XP_038055579.1"/>
        <property type="gene ID" value="LOC119727660"/>
    </dbReference>
    <dbReference type="GeneID" id="119727660"/>
    <dbReference type="OMA" id="YEKRRYK"/>
    <dbReference type="OrthoDB" id="533763at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14438">
        <property type="entry name" value="Hip_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000112">
        <property type="entry name" value="FAM10 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3420:FF:000001">
        <property type="entry name" value="Hsc70-interacting protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034649">
        <property type="entry name" value="Hip_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18253">
        <property type="entry name" value="HipN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="442" mass="47617" checksum="92CC5108860441FE" modified="2023-02-22" version="1">MDQASLDQLKAFVQLCKANPTVLHSPQLAFYREYLQSLGANLPTPPPPTEKPTSTASDESKPADAPPVPEPEPEPEPAMESEPEPAMEAEPEPEPEPEREPSSEESDLELDMEGVIEGDTDEPQHMGDDSLDVTDEMMEEASDKRSLAMAAVGDGNFDEAIKLFTEAIEKNPHSALLYAKRAGVYIKLKKPNAAIRDSDKAIKLNPDSAQGYKWKGIAHRLLGQWELAAKNLQSACKLDFDEVAYSTLKEVEPNAKLIAEHKRKYERKREEKDLNERRERVKKAKEAQEKARKEEEERRKNRGPTGMPGGFPGGFPGGMPGGFPGAMPGGFPGGMPGGFPGGAGGMGGGMGEGMGGGGAAGMPGGINLNDLQGFMQDPEIMAAFQDPEVMAAFSDVSQHPENIKNYQSNPKIANLIAKMQSSFSAGKDGPEPPQPPPEGDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZWC9</accession>
    <name>A0A913ZWC9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055822.1">
        <property type="nucleotide sequence ID" value="XM_038199894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZWC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199894.1">
        <property type="protein sequence ID" value="XP_038055822.1"/>
        <property type="gene ID" value="LOC119727825"/>
    </dbReference>
    <dbReference type="GeneID" id="119727825"/>
    <dbReference type="OMA" id="YCTILLA"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="620" mass="68593" checksum="6DAF72BC2854391B" modified="2023-02-22" version="1">MIFRFVDDYRLCCALSKLHHFSTEHNCHTTKPQSDLILCDSLMPNNILRAVLWVLGISALIGNLSVLIWRLTQKGVGGGKKTLSLMVGNLALADVMMGVYMLIIAVADLTFGEDYFLVAPEWRSSIMCKLAGVLSILSSEASVFFVTLISVDCFLGIVFPLKNFSLGGKSTTVIIVVLWFLALCLSIVPTLSFGSDSDIYGLSDVCIGLPLTTKTSGVNKDFLEITEGSVVKQFVDKIVHATGEKPSWILSIILFLGVNLVSFLLVLCCYVAIFVSVKRTASAVRVNAHREREVRMAIKMALIVMTDFCCWMPIIIMGILSQTGTVTLSTEVYAWVVVLVLPINSSLNPFLYTFFTVCCATKPKAKPQKKESNKPKLEQSATNTKKPTTQSKKKPTTQPKKKPTKEKKKATVIARFCVDEDEDEAIDQVQLFQRPDPPAETNGNSPVRDPWSSLKSSSPINTNQMVAVPLRDLLMMRRMASDVREIKECIRYCGFQPPTSSASLDPPSRSPTRPIAGHRTTAPSSPTMDLKSLSSDIISDIKDNSSSEANFALSLVRLLFSKTEMRESNCRGVKGKRQLDHVRIRAIKDILKSKTTIAGQRFDNYWHRECLKPLTKAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY46</accession>
    <name>A0A913ZY46_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055981.1">
        <property type="nucleotide sequence ID" value="XM_038200053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY46"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200053.1">
        <property type="protein sequence ID" value="XP_038055981.1"/>
        <property type="gene ID" value="LOC119727973"/>
    </dbReference>
    <dbReference type="GeneID" id="119727973"/>
    <dbReference type="OMA" id="FETECTR"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037483760" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="162" mass="18143" checksum="D151C57BDE1337EC" modified="2023-02-22" version="1">MLPKRLIVGLISLCLMIRCTGGNERCGASIRGACPPAWSRWGDKCYKQLSEDLPWAEAKQECIKMGSVLVMPQSQEETEFLLKNLAPFFRINCNDLQVEGTWVCQDGTTDVEYRNWREETGEPNNGAGGEDCAVTDKSGWNDVSCEFHAPTICKRPAPQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZS1</accession>
    <name>A0A913ZZS1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038056565.1">
        <property type="nucleotide sequence ID" value="XM_038200637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038056566.1">
        <property type="nucleotide sequence ID" value="XM_038200638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZS1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200637.1">
        <property type="protein sequence ID" value="XP_038056565.1"/>
        <property type="gene ID" value="LOC119728409"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038200638.1">
        <property type="protein sequence ID" value="XP_038056566.1"/>
        <property type="gene ID" value="LOC119728409"/>
    </dbReference>
    <dbReference type="GeneID" id="119728409"/>
    <dbReference type="OMA" id="QYAHPIE"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="199"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="364" mass="41860" checksum="5571FE8165F70EDD" modified="2023-02-22" version="1">MECATMREESCCAGPSRLPADDKPQEVKVGITQNRAELMSQWADTVKKVVFIVGGAIIVFAAACNSLTWHLESFWGASGDFWNRQWMKIYNLFGGNLFMLGVVGTELITFTFYWLFNAFFLFVDVTGRPAFILKYKIQEDQNTPVPWPKLKKALQTVLFNQVFVNIPFALVLYFLMQWRGCNISADLPTFKWVLVEMGVFLIFEEIGFYYFHRLLHHPRMYRHFHKKHHEWTAPIGVTAIYAHPLEHILANMLPPIIGPILMGSHVSVLWVWFMMVEGSAIVAHCGYHLPLLPSPEAHDFHHLKFTNCFGTLGFLDRLHGTDNLFRESKNYSRHILLLGIVPLSQTIPDDLKGKRKALESKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0K1</accession>
    <name>A0A914A0K1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057115.1">
        <property type="nucleotide sequence ID" value="XM_038201187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0K1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201187.1">
        <property type="protein sequence ID" value="XP_038057115.1"/>
        <property type="gene ID" value="LOC119728794"/>
    </dbReference>
    <dbReference type="GeneID" id="119728794"/>
    <dbReference type="OMA" id="VCERVEY"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF286">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="494" mass="55780" checksum="588FD37E60B65004" modified="2023-02-22" version="1">MKDDASKQQADLDREFASTTTLHGIGRVIESSRALVKLIWLTILLVCLGVCIWQITDRFRRYFKYEATTAVSVEYVGDLDFPAVTICNFNRYRLSVLTEADIASLEVLLEYTDYDYDTYDDPETPGEEPNPNEPAANFSYTEFTERTGFILDERTLMDCKWRGKKDSCKAHNFTHEFTSFGNCWTFNSGEDSDENDLPILHQIQPGSGNGLRMIIDIQQHEYAEPVQGGNLEAGLKVLVHGQETPPSVDAEGFAIGPGVHAFVGVRKREYNNLEEPWGRCDETKTLTHYEKYTLQGCSIECKAKKIYENCECRLVRHPGNEIECSPKQVKNCATPVLTQLKAGEIKDCECPVPCNYSEFRTSLSTAVLPNNNVMEELWKLYSPDDFANYTDDQSGLYIRENWILLDVFYESLNFEKYVQSEAISASALISDIGGQLGLFLGASFITMTEILEYLGRKAGRFFTSCSQRTTINPIKTRPREDTIGIKDLPSSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1R7</accession>
    <name>A0A914A1R7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038057772.1">
        <property type="nucleotide sequence ID" value="XM_038201844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A1R7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201844.1">
        <property type="protein sequence ID" value="XP_038057772.1"/>
        <property type="gene ID" value="LOC119729254"/>
    </dbReference>
    <dbReference type="GeneID" id="119729254"/>
    <dbReference type="OMA" id="ICAGCTA"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="436" mass="47335" checksum="DA7F9C437D8CDEB0" modified="2023-02-22" version="1">MAPSGYDASPYDHDKWGWVMVATLFICNLVVYGNLKALGVLLIPMTNDLDSDLWLVGLIAVFYGIMNRCMGPVVAAACRLLGSRPMMVFGGLLSTLGFMLTSISTSVFAVAVFIVGLSGVGSAFSLFINTATMASYFKENYPLAIGISTMGVPAGVMVYGPMTQVLLDTYGWRRTMLLLGGISFHLVACAVLMRRNPPSSAPDTEKYQEVAVSDEEEKKDNSSNYREHRARQCCQNILKAIDLVLLTDVRLVLLICAGCTASLTYRAWLVYMVPHGQFQGLSDFEASFLPTSYGVGNAMGKLIMPFLQQVGIKPSMALWACFGASVVCVSFLLHAFVRPFIGQLVITGLVGVGYALTYQANDVMIRFLHADDRFVSVLGWQGVFVGVAGILGGLISGWVYEWTGSFSIALCIFSGVILLSIPLFLAEAIYAKRKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A1S1</accession>
    <name>A0A914A1S1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057776.1">
        <property type="nucleotide sequence ID" value="XM_038201848.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057777.1">
        <property type="nucleotide sequence ID" value="XM_038201849.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201848.1">
        <property type="protein sequence ID" value="XP_038057776.1"/>
        <property type="gene ID" value="LOC119729257"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201849.1">
        <property type="protein sequence ID" value="XP_038057777.1"/>
        <property type="gene ID" value="LOC119729257"/>
    </dbReference>
    <dbReference type="GeneID" id="119729257"/>
    <dbReference type="OMA" id="ECYESDA"/>
    <dbReference type="OrthoDB" id="10069059at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF15">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="959"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1495"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1446"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1588" mass="171419" checksum="E1994C0CCD5AE062" modified="2023-02-22" version="1">MNGEDNTRSRGRLIEGSEVSQSPRRSLRSKSGSPVILRKAADEHSENRSPRKHIAHLSSEHSDVIVNGSSLDAPVKGRSRLAELREAVTRSPSRDQTSRDQSIMVREATENEDRPRRTRATGPADPVPEHTGCPTPGCDGSGHTNGKFSKHRTLVSCPVASKKRKLGSKPTSPEPQRKAKRSRRRGGGGNNTTSNQEEVDDEVIINNRPATRGATAATDPEDENSVSSLDDDPQSKCSRRAIVNLQKLLDNVTAEIDQEKKGEEGVEPTKKPAEAEVEAEDEEETLPDEEEEMKDAVSKETETEKDEELEEDAVEDAEEKEEVEEDADAEDDEEEEDEEEEAMEDDEVQLNLYNFKNISTSVGTEDQDDEEVCTPPKLHKELAFLNQEVSVLQGTAELSKSSSAPDGLEAKDGHLDTMDKDAGDATGTEMPTENSEDDADDDEDQILELVGEESGDDDAFSSVPPKPKEAGDEDDDDYNIAMPQLPKHLRLMSEQLSQELEEETKKHQSDESIPHQEEIPEEEPPQPVDQLIPAITTDQNAEAVQAESSEQTEIEDAPAEASQIETGEPPELQEELPEVMEETNKEPPIDEVPTEDGDALLSESMAVPDEPLVIDDKSVSPAEEDKENTAIPPTIGALLSAEPRVSFPTMSKMLTIPVIKTEPLDISASGQTSSIGLASSGMASAMSQMKEAMRNVSSAPMTSMLLADGTPVTTMLAPTSSLTKDFLEGCKCPTPGCDGTGHVTGLYHHHRSLSGCPHRDKIPQQLLQMHEHVLNRCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKHTGVKLPQQQQPQQQPGDPMNRFEGMPHVATSRSDHMVADMLNRPVCYVKQMDSGYQAFNNSAPRPSLPGDVRFSKPDGVLPFETKVAYNTGHKRIAPKIITASDLSPPVKKKLQAGDYDPNDCTIDSTSARMAATALNLSIKAPQLAPGQLTIPMQMPPPSHPHLTPQNAHQHPHSHPQQHHSQQHHPQQHHPQALTTPPTQISQRPLETVKVDSNGTLDLSMKSSKSSEVASNTHASSQSVPSPASVQSAANGLIQLSVPQPGVQNPVPSFITTAPTILQIPRSYGEQPMDFSTSMSKPQKAIKAPSIAVSCFPTSLTTSSSITVAAMLKTSNPDYDDPSSGAFMQFNKPRKIKGSLDGKREHLSCPTPGCDGSGHATGNYASHRSISGCPMADKSAIVQSTQELKCPTPGCDGSGHITGNYTSHRSLSGCPRAKKRSAMYAAQKAQAQAEASNEENPDDPMMRLPLPLSFINPPGTVNDYQWSVAELGRCPVPNCDGSGHLTGKYASHRSASGCPNASKVYHNYLREGFVGSEHPASPSAIAPKPVKMEPQNLSSCPIPGCDGSGHCNGNFSSHRSLSGCPKATSVMKKARLKEEEITAISIKAAQGIENDEDIRALDTEITELQHSNCQMESQMIKLRTQITSMEGKLHTAEKEHNAMEEKHRTLTHQLEELRNTLIKHLSDVQSQTASVPQQAAAQLPPPASGTAARSGLSRENIEAFLTTLETTATGGGSEDRPETPPEEDSAPMEFEAPEAATAKTVAVVGSATVNTIAVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2T6</accession>
    <name>A0A914A2T6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038057691.1">
        <property type="nucleotide sequence ID" value="XM_038201763.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057692.1">
        <property type="nucleotide sequence ID" value="XM_038201764.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038057693.1">
        <property type="nucleotide sequence ID" value="XM_038201765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2T6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201763.1">
        <property type="protein sequence ID" value="XP_038057691.1"/>
        <property type="gene ID" value="LOC119729199"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201764.1">
        <property type="protein sequence ID" value="XP_038057692.1"/>
        <property type="gene ID" value="LOC119729199"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038201765.1">
        <property type="protein sequence ID" value="XP_038057693.1"/>
        <property type="gene ID" value="LOC119729199"/>
    </dbReference>
    <dbReference type="GeneID" id="119729199"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000010">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="49"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="372" mass="40280" checksum="74DD38E42A6F9DBB" modified="2023-02-22" version="1">MSAPMTVFRGLLTPLKTSRYCSFAIINETKRCYCYNGKVRALVYAEYGDPVKVMKLSETDLAPLESNSVKIKMLASPINPSDINTIQGIYPIKPQLPCVGGFEGVGEVTEVGGQVTEVKPGDRVIPAVGTLGTWRSHLVCPVNHVMSVPLDTPPLIAATLKVNNCTAFRMLADFVELQPGDSVIQNAANSGAGQAVIQIAAARGLKTINIVRDRPNLDGLISHLQDLGATAVVTEESLRGHDANILKEMPKPKLALNAVGGKSAIITLVKALDDCGTVVTYGGMSKQPVMVPTGSLIFNDLKFVGYWMTRWHDRNAGSEEAKRMITQICQWGVSGQLRAPQHRLVPLSDYASAFEAAQQPYTSQKQILTFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3R5</accession>
    <name>A0A914A3R5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-8A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058310.1">
        <property type="nucleotide sequence ID" value="XM_038202382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3R5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202382.1">
        <property type="protein sequence ID" value="XP_038058310.1"/>
        <property type="gene ID" value="LOC119729699"/>
    </dbReference>
    <dbReference type="GeneID" id="119729699"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28428" checksum="43EE0945241922C4" modified="2023-02-22" version="1">MPQWTPSQYYTDLMPATAAAIARRPAPQSPPPEYVEPGVSSLAVTTRGYEHLYKFLFIGDSGVGKTSVIWRFSDNTFNGAFIHTIGIDFKIRTIDLDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNMKSFENIRNWIRNIEEHASSDVEKMILGNKCDMDDRRVVTKDKGEQLAIEYGIKFMETSAKASINVEEAFVTLARDIKAKMDRKLDTGGQGKGSSPVQVSGTTTQKKREWKFCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A3Y0</accession>
    <name>A0A914A3Y0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058380.1">
        <property type="nucleotide sequence ID" value="XM_038202452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A3Y0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202452.1">
        <property type="protein sequence ID" value="XP_038058380.1"/>
        <property type="gene ID" value="LOC119729737"/>
    </dbReference>
    <dbReference type="GeneID" id="119729737"/>
    <dbReference type="OMA" id="MFLEGET"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="336" mass="37945" checksum="4E38B9011DE7F00E" modified="2023-02-22" version="1">MAEHYQNGIVDAPPQRQGTRQMEGLNWPTMVTQECLDALKTYDVWEDDVWVTTYPKSGSHWVMEIVNLILADGNEQTIDRSQQSVPAEFDFTEANLGSGPGPRPKPVPQYKEMLTWKAPRVIMTHVTEELMPAQIYQGKGKVIFVIRNPKDAIVSKWHFSRAKGFGPRYEDWDTFLQEYLSGAGTYGTWFSYVSGFWKKHRHDKNFLFLMYEDMKKDLKGAVVQIADFLGKPLSEDTLNRVVDFSSVKSMKQRFHVNTAPAAKSGVPNADARAPPPGPSETLVPAARASEKIGAPATMRKGIVGDWKSMFTVAQNEAFDEVFRKEMKGSGLKIQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4Q5</accession>
    <name>A0A914A4Q5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038058798.1">
        <property type="nucleotide sequence ID" value="XM_038202870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4Q5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202870.1">
        <property type="protein sequence ID" value="XP_038058798.1"/>
        <property type="gene ID" value="LOC119730085"/>
    </dbReference>
    <dbReference type="GeneID" id="119730085"/>
    <dbReference type="OMA" id="DQQPANC"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001601">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002962">
        <property type="entry name" value="Zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="572" mass="65178" checksum="D178A5D376132B16" modified="2023-02-22" version="1">MKMHTGERQFVCETCGKTFSRKTDVIRHDRVHTGEKPFVCEICGKTFSRKIDVIRHDRVHTGEKPFVCEICGKAFTCLSNLRRHERVHTGEKAFVCEICGKAFFQRTNLKEHVKVHTGEQPFVCEICGKAFSHRTNLKRHIKVHTCEKPFVCEICGKAFPLRSSLRKHDSVHTGEKPFVCEICGKTFTCLSNLRTHKRVHTGEEPFVCETCGKAFSQRTNLKRHFKVHTGEKLFVYSCYVTLRRLLEHSVVDFRESDPITDRPEEDQQPANCDDTPMILSRQVLSSTHTKKVLAGEKPFICETCVKAFSQQGSLSRHAMMQAEKETFVNAGGPCGEAFNVRSTPNRHEKDHTGDKPFVCETCGKTLSRRSSLKEHTKIHTGEKPFVCEICSKGFSQRSFLKTHFRMHTGEKPCVCETCGKALTCQRNLTVHMRGHRGEKPFVCEICSKTFSQRNNLKKHMGVHTGVVKPFVCDICSKAFSCRSYLRKHERVHTGERPFVCETCGRAFSHQSTLKGHIKVHTGEKPFVCETCGKAFALLRYLRKHDRVHSGEAKKQIVLLPVSQPTIFLLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4Z4</accession>
    <name>A0A914A4Z4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macoilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Transmembrane protein 57</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of neuronal activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Rough endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038058922.1">
        <property type="nucleotide sequence ID" value="XM_038202994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4Z4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202994.1">
        <property type="protein sequence ID" value="XP_038058922.1"/>
        <property type="gene ID" value="LOC119730205"/>
    </dbReference>
    <dbReference type="GeneID" id="119730205"/>
    <dbReference type="OMA" id="ENTHADT"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47464:SF2">
        <property type="entry name" value="MACOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09726">
        <property type="entry name" value="Macoilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="664"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="730" mass="81837" checksum="64618A1204FE7826" modified="2023-02-22" version="1">MKRRNAECGKLRRPLKRNKIAEGIYGSTFLYLKFLAIWMFVLLLDFILEFRFEYLWPLWLLLRSIYDSYRYQGLAFSVVFIFIAFTSDMICLLFIPVHWLFFAASTYVWVQFVWHTDRGICLPTVSLWLLFVYIEASVRLRELRSAIPFHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRMRLRKQKEVQKENDFYIQLLQQALPPEQQQHHQLHNASLTAEKQKGAIASKAEEPTSNGVVSRKGSPVIQGNKGSSSDGSSEKSREPPASQRKQQASNNAGVGGTTAKNPADPELIETKLPPRSVNDYDGSKENLANEQVQAKNLKQQQQSSVSSGQRGKNQPGKDNSGSTSGSKKPKPLASKLDNKEKEKDTNLNADIANGAVPTPPAKDEKVLRLESDIKRLKADLQASRQVQADLKTQVNNLLSDDQHDKAELEQMKKDYESLQTKLHNLVTQKQQDKQNISRLEQQLKAERDQRTSLETQMREERKNRKAKEAAAARAAAMATVGRYGECGDSCRMRMLDQDSEILRLRKESRDKDDHLREMEKKTELMHERQESQNKTDLLMSALMAMQDRTAKLETSLSAETRLKLDLFSALGDARRQMEIMQTELMKKEREIHDLKTKIAEHMAVMPQSNYSGSGSPISGTPRYSVNFVSSEETGPILPMGVPVSQGMGPPPGVASASSTPVSAPQGSSSSQSPSPSVSPVPSLGNGKSVLDPNAAVYRPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A7V9</accession>
    <name>A0A914A7V9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059885.1">
        <property type="nucleotide sequence ID" value="XM_038203957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A7V9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203957.1">
        <property type="protein sequence ID" value="XP_038059885.1"/>
        <property type="gene ID" value="LOC119730895"/>
    </dbReference>
    <dbReference type="GeneID" id="119730895"/>
    <dbReference type="OrthoDB" id="10093692at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037412456" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="166" mass="18803" checksum="DE5AD6998BFA94C8" modified="2023-02-22" version="1">MNACHVIFVVAISAIMILGANAYRKYCYCDLRWSTRELRAGQSANGLSVLEDLPNPSYHHWLIPSCRRVNQNCPDDCLDEAHDWMGGARFTNTAGQLACESVRRNAPPGSPIYVYATYDSVCGDRTWQYVAPLCCWELSFPQYDISGIFRYNHRCEEPCPPNRPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A944</accession>
    <name>A0A914A944_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059956.1">
        <property type="nucleotide sequence ID" value="XM_038204028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A944"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204028.1">
        <property type="protein sequence ID" value="XP_038059956.1"/>
        <property type="gene ID" value="LOC119730957"/>
    </dbReference>
    <dbReference type="GeneID" id="119730957"/>
    <dbReference type="OMA" id="ISTRRYC"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF26">
        <property type="entry name" value="RETINOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="339" mass="37908" checksum="E93E50BB069911EC" modified="2023-02-22" version="1">MALLSRVCKWLVPILVVLYAVFYWQVITNRKYFTNDVKLNGKTTIVTGGNSGIGWWTALDFAQRGARVILACRNLQKAEDAAKEIKTRTGNSEVVVRKLELSSLKSVRDFAQQINEEEKRLDILVNNAGLSRLKQRSSATEDNFDLVFGVNHFGHFLLTNLLLDLLKKSAPSRVVTVSSATHYFAPEPMNLTREDPAVASLLYPHLEGYNISKVANIQFGRELARREASSGVVSVSLHPGTIYTPIWKSLMTAETDSVWMKTLYYTLSPLMWLFFLDEEAGTQTTLHCALDDSIPQLSGSYFDNSQVMAPSALAEDDELARRLWQVSCEATGLECTSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AAX7</accession>
    <name>A0A914AAX7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YHYH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060913.1">
        <property type="nucleotide sequence ID" value="XM_038204985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AAX7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204985.1">
        <property type="protein sequence ID" value="XP_038060913.1"/>
        <property type="gene ID" value="LOC119731744"/>
    </dbReference>
    <dbReference type="GeneID" id="119731744"/>
    <dbReference type="OMA" id="CHGRYVD"/>
    <dbReference type="OrthoDB" id="197925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025924">
        <property type="entry name" value="YHYH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF8">
        <property type="entry name" value="YHYH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14240">
        <property type="entry name" value="YHYH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037308763" description="YHYH domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="YHYH" evidence="3">
        <location>
            <begin position="86"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="YHYH" evidence="3">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="269" mass="28517" checksum="B0ADBA7FCA5BFA22" modified="2023-02-22" version="1">MTSAAMLPITTCLLAMVAMSSALTDDQIARFMTSDMVEGNTGETGMVTITTANGMHTITSNGVPDHATADYPNLANPNDITVQTHEWEIPVNPTVADSTTDLPMGPIGVAINGIPFFNPYTATGEDAVLTETFDSCDGHPTNRGTYHYHKQPSSCVFSIVDGEPSPLIGVALDGFPIYGPNDENGNTLTSSDLDECHGRSVNGQYQYHTTSDFPYIMGCFKGEYTSTLPPNGPPDGSQGTNMPPDNGQANLKSSLLAILSVLALMVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABF7</accession>
    <name>A0A914ABF7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM241 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038061234.1">
        <property type="nucleotide sequence ID" value="XM_038205306.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038061235.1">
        <property type="nucleotide sequence ID" value="XM_038205307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205306.1">
        <property type="protein sequence ID" value="XP_038061234.1"/>
        <property type="gene ID" value="LOC119731967"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205307.1">
        <property type="protein sequence ID" value="XP_038061235.1"/>
        <property type="gene ID" value="LOC119731967"/>
    </dbReference>
    <dbReference type="GeneID" id="119731967"/>
    <dbReference type="OMA" id="LIYIVSH"/>
    <dbReference type="OrthoDB" id="10060343at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027953">
        <property type="entry name" value="DUF4605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052502">
        <property type="entry name" value="FAM241_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33690">
        <property type="entry name" value="DUF4605 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33690:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15378">
        <property type="entry name" value="DUF4605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4605" evidence="8">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="157" mass="16487" checksum="11B4B9661118FAFA" modified="2023-02-22" version="1">MVRILANGDIVQDDDPRVQQSSHSGNAPTNRGSRMGYIQQNTEPHQYGHDGQGAGGHEVQNVSIFQTLNQRLLDLGIPCFNIGPYTIQPIVTVAFILAMLIFGLPGLLFAGLLFGVVMLSGGGGGGDDGGTGGGGGQSTGRGDGQRRHRGGRVLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ABJ6</accession>
    <name>A0A914ABJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061118.1">
        <property type="nucleotide sequence ID" value="XM_038205190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ABJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205190.1">
        <property type="protein sequence ID" value="XP_038061118.1"/>
        <property type="gene ID" value="LOC119731901"/>
    </dbReference>
    <dbReference type="GeneID" id="119731901"/>
    <dbReference type="OMA" id="DITICHF"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036825403" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="185" mass="20472" checksum="F96C978EE7F7CE38" modified="2023-02-22" version="1">MAGKVYFRILHVAVFILFVVGVSGLCTQHWFEHGTRCYKTDNITRTWNDGAAYCDGLGGELLVIETLEENEFIHGLLKNQSKEWAWLGCSDISTEGQWVCYKDAASGLPLKNWATDQPNNAHGTDHCLAIHSKDGKWSDSNCDVQFVYTVCETTSVQRKGEVVTASSSATPISCYTLGSDGRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AC91</accession>
    <name>A0A914AC91_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061540.1">
        <property type="nucleotide sequence ID" value="XM_038205612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AC91"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205612.1">
        <property type="protein sequence ID" value="XP_038061540.1"/>
        <property type="gene ID" value="LOC119732189"/>
    </dbReference>
    <dbReference type="GeneID" id="119732189"/>
    <dbReference type="OMA" id="NICAGIH"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041940">
        <property type="entry name" value="choice_anch_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF177">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037976438" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="331"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116060" checksum="F3B5367AF25E2B25" modified="2023-02-22" version="1">MKLQGACLIVATLVLVYSNVDALLRPSSIRLENNSYTGIVVAIHSNVNESVELIDRIKYMFYEGSKYLYEATRKRAYFDKVTIIVPKTWTHKSEYKLPGNLTFDYADVIVAPPNPRWAPLQYTKQYQGCGQRGVHIHFMDEFLTDPEVELYYGPLGRVLVHEWGHLRWGLFDEYPDAVGDPDNYQEFYFSPLTQQFEGVRCSYDHNAFPLKFFPESQMYRPCNGGPDIGYEEGCVYYVVANQDKDLVSSSIMFSSYPLGPIKYFCDNDSSDSPNLHNREAPNKHNRLCTSRSNWEVLRDHEDFRNNINPPREISEDDLMPEITIVQHQDIRVVLLLDTSGSMTSKNRFNKMISSSANYISSIVTEGSYIGIVEFNYVGIIRKNLTLVTSDDDRQALLESLPPDAGGSTAIGDGLLKSIEVLSEGGMDPAGGIILLITDGKENVRPNVADIMDTIISSGVIVDTLAFSQNADGLLPGLSQATGGKTYFYSDEVGSNTLYEAFAATMERGDVLDSERRVQLMGTSWSLKSDEERTSSIFLDSTLGRNTEFVFSWETENVLAIDVNITRPNGSMIDWSYEGYGVDISFRILTVSIKGQAEAGSWKFKVWNNGTQSQDVVVTIYSYPASNDVEPIIVTSELSGSTTAFEQNEPLVAYAEIRQGFRPMIYANVWATIERPQAGYEPIKLQLLDNGAGADVTKNDGVYSRYFTEMTGVGYYGVTIDVDNNEGNAIVIDSNPFSKSRPIVDPDDAFNLPDIGGVKIPSPGEPPAEPTGTPAPAFSRGTSGGSSRVDATPPGFSPGADLFPPGDILDLRVTNTSFLDKTVSLAWTASGDDLDSGAASWYEVIRAESVLAWQSDPDPESHLILNSSHVLQGNLSAPQVFGSREDLQVMVPVPEEVNVTSYAFVLRAFDDAGRWSEFSNVVQAVLREYVPESLPAPAPATTNAPPATSNPQPATGDASPVMTDAPPTTRDAPPVTTDAPPPTTDAPIVVTVTPPSTWLQWWHIALMVVGGSVGLSLLIGLILCAVLKGIPSKATPVSPIIVAEAGEHTNRAYAHEWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AD92</accession>
    <name>A0A914AD92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_038061895.1">
        <property type="nucleotide sequence ID" value="XM_038205967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AD92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038205967.1">
        <property type="protein sequence ID" value="XP_038061895.1"/>
        <property type="gene ID" value="LOC119732443"/>
    </dbReference>
    <dbReference type="GeneID" id="119732443"/>
    <dbReference type="CTD" id="286971"/>
    <dbReference type="OMA" id="KLWDYVH"/>
    <dbReference type="OrthoDB" id="9993460at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF198">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="113"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="250"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="60854" checksum="123BFC398BC47F75" modified="2023-02-22" version="1">MEPSVRQRGRSTSKTVQEQLPSQQSTSGKAGFRLKYVILFLCLLFTAIFLGTYFLLGAIGIGYDTLSSGILPSNLKGHFAKGDEIDLSKPKDDLPAKAKPSLKQPNSKALPLPTIVWWTDKLFPHFQGQNTVKIECEPHQGGLGTCLVTTDKNVLSDPLARGVMFYGSDFRAYEAPLPRQPWHEWALLHEESPLNNQIFSHDVMMSQFNHTSTFRRESHYPITTQHINNLEYFTERKPFPLNVKNQHREKLAPIVYIQTHCNVPSDRDRYVKELMKYIDVDSYGKCLNNKKLPESLRDPVESMEAKEFHDFIARYKFHLAFENGICEDYITEKLIRPLHVGSVPIYRGSPSVKDWMPNDHSFILADNFDSPQKLAEFIKGLDKNDKEYLRYLEFKDKGIDNELLRDTMAKRVWGVNEWRKPSFINAFECYLCGRIVERLEAEQAHERDPSAPLLPPSMANGNHVGCPEPTVSFGDISGVARGEDIHFWKEDYWGSKDQAVALKRMIDRGATDSSKLFEELQKMFAEGLLESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF76</accession>
    <name>A0A914AF76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038062024.1">
        <property type="nucleotide sequence ID" value="XM_038206096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AF76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206096.1">
        <property type="protein sequence ID" value="XP_038062024.1"/>
        <property type="gene ID" value="LOC119732534"/>
    </dbReference>
    <dbReference type="GeneID" id="119732534"/>
    <dbReference type="OMA" id="FIDASCC"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="153"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="305" mass="32832" checksum="5630A06A3DD181D3" modified="2023-02-22" version="1">MAGVAAGYDVMLFSSLRSEAAGASWGGFVCPLIYHQPDGFWIIAFVTMDGAVAWILMASALTVLASCHKVCFIGSEYNPQAGIPPRWFLPYKDPCECTAIRLGGMQMPASSYRQGAPHYLKELFLSEDSDEIQAYFKCSRTTTASGTTSAGGATSAPLGMKDGTIPDDHITASSFIDASCCTPQKGRLNSGGVWKPSSNEGSWIEVDLATSTVVSGVITKSLTNSRYPGYVTKYKVAFGNQSTSNSTYVTDANGNAKVFKGNTDHDTPVTNLFDESVVATVVRIEPTEWHTRVRLQLELLGCRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFM5</accession>
    <name>A0A914AFM5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062306.1">
        <property type="nucleotide sequence ID" value="XM_038206378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFM5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206378.1">
        <property type="protein sequence ID" value="XP_038062306.1"/>
        <property type="gene ID" value="LOC119732770"/>
    </dbReference>
    <dbReference type="GeneID" id="119732770"/>
    <dbReference type="OMA" id="FERTCAN"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20694" checksum="B90CB5392AFB8F17" modified="2023-02-22" version="1">MHSCSACQSLFITSCLNGPLDCNCAMGKLWAQILMLLLAMAIAGSALKCNFCHSIFVPNPECKKAGTESKFLVECPAQPEGYVTRCGKADGILSTKTGRGLINMKDFELECSNVKSSHVPENKCYVDNEAIPWFYETLDPASRSYAESLSLNVEFKGTVCFCDTDGCNAAFPHRHHIQKRMLTDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AFT8</accession>
    <name>A0A914AFT8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062371.1">
        <property type="nucleotide sequence ID" value="XM_038206443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AFT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206443.1">
        <property type="protein sequence ID" value="XP_038062371.1"/>
        <property type="gene ID" value="LOC119732839"/>
    </dbReference>
    <dbReference type="GeneID" id="119732839"/>
    <dbReference type="OMA" id="RNTEHMD"/>
    <dbReference type="OrthoDB" id="6758782at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="204" mass="23065" checksum="0D0677506A19A7A3" modified="2023-02-22" version="1">MEQEQHGTIPFLDVKISRNLDGTLGHSVYRKPTHTDRYLHQRSFHHPSIKSSVNRILVQRAFEVCDQDNLKRELKHIQASLQWKGYKPNCITISKPDQWVSYTQGPSTVSPSVTLPYIGPASHHLQRILRQAGIKVYHSLATSSKAASTLTRTSRTPLPRRESTAFYVNAAKSTSAKPVGTFPLGSRNTEHMDVRYTWSETLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGD2</accession>
    <name>A0A914AGD2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Multiple epidermal growth factor-like domains protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038062576.1">
        <property type="nucleotide sequence ID" value="XM_038206648.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206648.1">
        <property type="protein sequence ID" value="XP_038062576.1"/>
        <property type="gene ID" value="LOC119733067"/>
    </dbReference>
    <dbReference type="GeneID" id="119733067"/>
    <dbReference type="OMA" id="GECYCTH"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000191">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF16">
        <property type="entry name" value="MULTIPLE EGF-LIKE-DOMAINS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640485" description="Multiple epidermal growth factor-like domains protein 8" evidence="15">
        <location>
            <begin position="26"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1109"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1185"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="1233"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="1285"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1203"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1267"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2140" mass="232965" checksum="8023B8B4F452A048" modified="2023-02-22" version="1">MDCACSTLVLSVFLFICGCGRLATSAGCSGLRRALLTDLEGTVTDGVGFYEENVHCEWLIEAPDPNMTITLTFKEFETECTYDFLTVYDGDSFTSTVLGTFSGNLVPGPVQAKSGKMLIHLYSDTNYPLNGTTATYKIQNCSNACSGHGVCQNYQCACDSGYKGSSCEWRTCPYECGQSSSRGNCDFLSPVQRCACSAGYVGEGCSLSTNDNTGWGDTVLVSSGIDSIFKARTGHTAEYHEGTDSLWVFGGYDLNGVLDDIVRYNFTSNQWERAVPATATRPTGRYAHSMVLYYDDLIVFGGILANGSLTNELWAFDITTRVWTLLPVGSDLASMPPGLADHSGTIVNFSHLYVFGGRSQNTNFVDGIFKYDLILRSRWDVIRPLGGREADVRVRGHSAVYHMDSQSLVVFGGFRPSSTRFSERSNEIYAFHVDERYWMKWSVDMSGAPMGRAFHSANIIGNYMVIYGGNVHRHYTRPEDHYPPTHERCYDERIELFHLGCHKWADFDTLAQGFQSPAETEHLHRVTRGRFGHAAAVRDGSTLLVVGGYSGQVLHDLIAVKMPGTVAVNSKLGGSILDQCGMHSTKAICLSDPNCGWCAASSNCLGHSQQSSCPEPQSFLQGSCPSICNSLVSCEACIIWGKGVTLSDPSGSRVNEQCGWCVQEQQCYPIGEPGGACGDHSSSTDPTGWWGLNGTFVTEFAQCRLQDMPPGMTWIKYRHPQNTTQPDEVTIVEKTDRSFSFYYVSIQEEKTNGGEYIAEYKGFLRPNDAVPTGDAQLRVWMGSSNAISSLYLSTDANPQNAERVAYYALDDEQLVEAERPNNAAVFPVNSKTAAYYVLQEERQVIKMSAVHSVMDLKWNGNHPLGLVSQTFSREYLQPYYSGACDSYVTCSGCLTDASCGWCPASETCELRSKTTAAEDHCGTATGAIMHHLITQWDQCLDCKLYVDCLSCTENPLCEWLISGDDVRCTRRGRFLTSIKDPNQCTLNCHEYTNCSDCSKRTKECAWCEETKSCFTFGTYVTSFTYGQCPNWFDLNKACPSCAAHTDCKSCLADFKCGWCGNRDNPTLGNCQEGNFGSPDSAQSCSALVAAQYNISESEPADWSYRICPDVEECMLELDDCHANATCANTFDSYECTCNRGFEGNGRDECVKTCYHECIHGRCSGAPDYTCICDVGWNGENCSTDCECNFHSTCETGIGICDECQHWTMGQFCELCRPGSYGNATDQSQGCRECQCNGHGDATLGSCHNETGICYCTENTKGDHCEECVTGFYHDPRFAQHCSRECSGRMLLTNVESAALGSGQGDGVTLSEAYCLWVLTAGDNLTHTAAMTDPPTISLTVEGIEALCGRDYMYVYDGIPSYLSSSHPELAGADLGAFCGQDPLERVTAVAHSGIMTVVYQANHTGSTDSPGFVASYSVNRCPGGCHGNRECILGTCRCISGYRGPNCEEEACPGNCSQADGQGICDEAMGVCNCSAGFGGEACQFPTSPLAGLKQGIWTLLADEARLDPDASSTVGAVPCGRMGHTLVASEANVLWLFGGYSHTHGHLNDVWSYDLATKKWKQHFSGSSAHPAPRRYHAATFSSSYVMISGGMNDTTVMQDVWYFHTVSENWSQIPAVFPVALAGHSFVVVKDETLVTIGGYSPTNGLQDKVLEFSVADNAWLAVQTTGPPPTGLFGHSTVWHSTTKALYVYGGYLFHLDSVFVSDRLYSLDYRNSVRRWNLLLAEPGNQPLPHIFHAAVTTSNYMVVIGGGTPTQNISNTLMAYHYDCNQWVDLNDFVVGSPPSPSASLSAAIVTGNAIYTFGGNDGTSLGALYQLNLPTDLCALQTTTDGCLGMPSCAACVETNDTQNLLFCKASMDVYQASCDGIYSLEQGITCNDARVEYRNCGAAKSCSECVMTQPAHYTAEQTCKWCSNCPDGACISRQLDCMEVHNCQVDKQKEISDANQCPELECEASDCDKCVAEDCIWTRQFKRASEVRRLLNANPTYDWNCFRESLLQIAPVDIHISSSPNEPCPSPCYTHNSCTDCLDSKGAEGGWQECVWSARLGQCLSPTYVPLVCSTGACGPLTHSGSHNCPQPCYLNTQCAHCLRQPGCGWCAVGQGNGTGVCMEGGLYEPTGGVCSAEGVGLNNFPVEGEMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGT0</accession>
    <name>A0A914AGT0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062922.1">
        <property type="nucleotide sequence ID" value="XM_038206994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGT0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206994.1">
        <property type="protein sequence ID" value="XP_038062922.1"/>
        <property type="gene ID" value="LOC119733418"/>
    </dbReference>
    <dbReference type="GeneID" id="119733418"/>
    <dbReference type="OMA" id="PAKICEH"/>
    <dbReference type="OrthoDB" id="6112405at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="71720" checksum="B6839DF6D0B8E567" modified="2023-02-22" version="1">MATGRAVSSALEKIIRHHLECSICQGRYQQPKILECLHSFCEQCLLKYCSTKHQGATAIPCPVCRQETELPEVGVQGLKTNFHLIGLVEELELQEKLVCSGGTKLLCETCDDGNEATRRCLDCAQNICSRCHSSHKRIATTSSHTIATLEDICEGKVKLTKENLKQHPKCPKHEGEVTRFFCMTCEVLICRDCTVIDHCKPEHSYIDRNQAASTYKQSLAELFSPLGYEMKELKKSQEEVSRIKEDLGVTVKRVRTEVQDRAAEIRAEVTAQENRILNDIKNIQTDREQKLDECEKNMGLAAERFQYSLDTAREVTRTASDSDFLSLYPTISKDLKLLADQRMPRVDNRLAFLKFKQSEGVGGISLGEVVVEVEWKLCCDREFGRIGSGPGEFDGAWGIAARQPDEIAVTDYCNKRVVICSIDGDQKSMIPMQGCPLGIAATRAGDRLVVVEEGASHVKVFNSNNTLAYEFPTVPPSDEVDKTAVDLHSVAVKNDDTIVVGDARRMVLTEHSPTDGELLRTIPVKIKPYFLAVDDSNDRIVISDKSQAVDVADGNGTTRRTIKPTMNDEPVQYCNGVYTDSSGIYVAMENGPSTRHIHHYDPQGGFLKCIAQGLHAPLGITLTSDGQLAVADWYSIKIIHHVAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHU8</accession>
    <name>A0A914AHU8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063243.1">
        <property type="nucleotide sequence ID" value="XM_038207315.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207315.1">
        <property type="protein sequence ID" value="XP_038063243.1"/>
        <property type="gene ID" value="LOC119733951"/>
    </dbReference>
    <dbReference type="GeneID" id="119733951"/>
    <dbReference type="OMA" id="NIITEMA"/>
    <dbReference type="OrthoDB" id="10068969at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1385" mass="156406" checksum="875C9FFA43ABF904" modified="2023-02-22" version="1">MLVKKELVKSGIRKFKGSAGNYRAWKCSFQQATKDLELKPYEELNLVLGSLEGETEMFVQRIYSIHIDRPEEGLKRTWEYLEQKHGSPEAVERDLTGRLEQFQKISPKGSTKLEEFGYLLLEVQYLKESEKFPGLLALDSSRGLQPLVQKLPEWLQNKWREKGSEYKKKHAVLFPPFEEFVKFIQHHARVQSDPSFQFTDAVKSAAERSSSRPSFTVRKTGVEEGSAAKETSRCPVHNTAHKLQDCRVFCQKSIDEKISFVKENRLCFRCLRANHIIKNCKTPVRCDICGKSHVTVMHRPAPSQEVPPASNQTPPTMKYDNRPQIIVTPKCTRVCGNGKEGRSCAKICLAKAYLEEKPDHVITTYVIIDDQSDGSLINENLLERLGVKQNKSTYAVKTVNGLQEVHGRKLSGLVIESMDGTVSAPTPTLFECNNIPGDVAEIPTPEVAAAFDHLKPIAPMIPPLNKDAEIAVLLGRDAPQFHKVREVINGKDDQPWAHRLDLGWVVVGEVCLNGAHIRTDISYLQQDVISTYFTQVLRNGRHSAQFQPCDKAVKVFHTRPKAAELGEEVFISTSADERLGPSSDDREFMELIAGKMKKDQDGNWCAPLPFRKNRRRLPNNKTQAVSRMKALASSLAKDEKKRQHYIEFMRKVLEKGLAKQVLDEATSASEEVWYLPHFGVYHPQKPDKLRVVFDSSAIFSGISLNDVLLSGPDLMNQLLGVLIRFREEPVAVTADIEQMFYAFRVREDHTRFLRFLWYEDNNPNAAIVTYCMTVHVFGNKPSPAVAISGLRKTAEEGEAEFGTDVRELIERNFYMDDLLKSFPTKEEAVDVLKRTKDLLSTANIRLHKFASSDAGVLAAFEPSELAPNLAEADLSNKDESTIRRTLGVSWDLKADSFTFQIAEPNANACTKRTVLSEVNGVFDPIGLAAPVIIKGKMLLREMTQDGGGWDDPLPKDLLQDWVMWRKSLIALTDVRVPRSFAPFSTTEVVRRELHTFGDSSNKAIGAVCYLRTVGSNDEVHVQLVMGKAKLAPKAAVTIPRLELCASVLATEMEDYVTQELQIKVDESKFYTDSKVVLGYITNRKRRFRTYVCNRVNRLLKTSEPEQWTYVPSERNSADLASRSILAAELSGSMWIAGPEFLRLKDLPSSHKQREIEILQDDPEVSPEKISCNKIVLPDASFGSERFTRFSSWDSAMRATTNLIHIANSFRAEFDCKGWHVCEKAKSIRERLKAETVIIKSVQSEAFATELAELRSGKLTKKNKLASLNPYLDSNRVLRVGGRLQKAQLSERATHPAVLPKNNNYVTKLIIKHFHQQCSHQGRHITLGTIRNEGYWVLDGQRHIRKASVEMVAADQRSLFLQPARELTKKTLLRPISDLVLLIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AHZ5</accession>
    <name>A0A914AHZ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063161.1">
        <property type="nucleotide sequence ID" value="XM_038207233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AHZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207233.1">
        <property type="protein sequence ID" value="XP_038063161.1"/>
        <property type="gene ID" value="LOC119733867"/>
    </dbReference>
    <dbReference type="GeneID" id="119733867"/>
    <dbReference type="OMA" id="WIRWHAR"/>
    <dbReference type="OrthoDB" id="10055277at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="223" mass="25742" checksum="62E0FC5C94DD911A" modified="2023-02-22" version="1">MVGFDITDDTRKKALLLHYGGEELQDIYDTLKSDSNDYAAAKKALTDYFAPKKNVVYETIIFRRTKQNTTENIHQYCTRLRQQAVKCDFSDIDRELKTQIIEGCTSKHLRRKSLEKDRNLTELLELARSLSLSESRAHDVEADGSQTAVNKVAKPKRNFKKPTRHDTKPPKRTCFYCGGSYPHKNQCPAKGHECSKCGKQDHFEKVCRSDKQRKNTPTRKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJH6</accession>
    <name>A0A914AJH6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12 15">Uricase</fullName>
            <ecNumber evidence="5 12 15">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12 15">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 15">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 15">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 12 15"/>
    <dbReference type="RefSeq" id="XP_038063711.1">
        <property type="nucleotide sequence ID" value="XM_038207783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038063712.1">
        <property type="nucleotide sequence ID" value="XM_038207784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AJH6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207783.1">
        <property type="protein sequence ID" value="XP_038063711.1"/>
        <property type="gene ID" value="LOC119734337"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207784.1">
        <property type="protein sequence ID" value="XP_038063712.1"/>
        <property type="gene ID" value="LOC119734337"/>
    </dbReference>
    <dbReference type="GeneID" id="119734337"/>
    <dbReference type="OMA" id="WVTGGRW"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7 12 15" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="315" mass="35765" checksum="9862B7B67C811328" modified="2023-02-22" version="1">MPIQANGRELKNKMSTSPQVEFVSKGTYHGKHGVRVMQHRRQGGTHSIREITVKTLLGLNTRKEYVNSDNSDVIPTDSQKNTVYALAKAKGITTPEQFALDLCQHFMGKYNQVQWAEITVEDAPWRRIVDQSGKEHAHAFIQTQEAKRYCVVKQERKGLPIVWAGLSDMRILKTTQSGFAGYFQDEYTSLPETDDRIVCSNIESKWRYSNIVGVDFDKTWELCKVAILDEFAGPPDIGRFSASIQEILYQCTQRMMKKVAEVDQVELDMPNIHYVFADLKKIGMENTGEIIMPTSDPYGIIRVAVSRTHSTPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ALK4</accession>
    <name>A0A914ALK4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064885.1">
        <property type="nucleotide sequence ID" value="XM_038208957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ALK4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208957.1">
        <property type="protein sequence ID" value="XP_038064885.1"/>
        <property type="gene ID" value="LOC119735252"/>
    </dbReference>
    <dbReference type="GeneID" id="119735252"/>
    <dbReference type="OMA" id="GNCEEEM"/>
    <dbReference type="OrthoDB" id="6144714at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="231" mass="27177" checksum="22B0A18973608F0A" modified="2023-02-22" version="1">MHMGNNNPGCIYQMGDTKLQERDQEKDLGVYICNNCKSSVQCAKSAQKAMNSLRVIKRTFKHITKDSFAVLYKTYIRLHLEYCVQAWNPGLRKDIHTLEKVQRRATKLVPAVRHLSYPDMLEALDLYSLEQRRTRGDLIEVFKIFNGFDKTEPTRFFKISNTRETRGHNMKIFKSGMNKALRCRQDFFSQRVVNTWNDLPSYVVNAKTTNSFKHELDEYWKRYGVIKAYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMJ8</accession>
    <name>A0A914AMJ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication protein A OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064962.1">
        <property type="nucleotide sequence ID" value="XM_038209034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209034.1">
        <property type="protein sequence ID" value="XP_038064962.1"/>
        <property type="gene ID" value="LOC119735339"/>
    </dbReference>
    <dbReference type="GeneID" id="119735339"/>
    <dbReference type="OMA" id="FIEICDI"/>
    <dbReference type="OrthoDB" id="6088167at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34545" checksum="906AABF6653A2952" modified="2023-02-22" version="1">MEGASESRGVQGSQDKMPKLQDILDHHHSNPQHISVLICDKEDSDQATASNGIKFAIADSTTCCECIMYDVSKLPKMTLGSSIALINPMVKQSPQQQILILKRTRVISAGKVEVPTEIAERAKTLLHPQPAPFIEICDIPTSPLSKMVSVKGKVIGQEVPQTVISNGRQTKVKNITLKSHDSTCRIALWRSFVDQEVKDGEILQVTNTVTSEFRNEVYLSTTGLTTVKKLDITQMKETTTVIGFEVLEWDTSAFQVTTDQERYPSYLIEKEQLAALFSVPEEDAEKTLQQNIPFTCNITVSDNKITTISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMQ1</accession>
    <name>A0A914AMQ1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064873.1">
        <property type="nucleotide sequence ID" value="XM_038208945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMQ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208945.1">
        <property type="protein sequence ID" value="XP_038064873.1"/>
        <property type="gene ID" value="LOC119735240"/>
    </dbReference>
    <dbReference type="GeneID" id="119735240"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="93"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="254"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="406"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="544" mass="60910" checksum="6B4ADC2C1D8B2626" modified="2023-02-22" version="1">MAKAITISRGSQLVFRLSTTRHWPVVSLDLQLAFQFYGLAPVVLEGSRLYSRLVGYKSTKQRRSMERTWSSCGMCIVVMMLLVHYVDLSSSVMTREYCLRHENLTVAPCLSGGIHRNVNNITYFPNFLGHQTSQEAIGGFNDFYPYLQVQCSPNLQQFLCAVYFTWGCEVIGYPIFPCREFCERVRDDCDWAFRRAGTAWPDSLDCNDFWIDSRDHFCIRDPGEPDEPDSEEDKGNGEDNLPSTIVPPPTPRPDPSEHCQPLPDDPICQSMPYTTVIYPNILGQGNHSDALVELHRYSAFMSDGGPCSDLLRTYLCLAYLPPCKIVEEVAAPIPPCKALCELVLTDSCIGALAAFKMELPSTLSDCSMYPKQSDSYPTCFIPGAGYDPLKYWSPPPVITTDLTYQCKTTGCENVLHGKCHSFGFWMVTFPNLLGHTNMQEALDDLDRLVPFIDSGCSDKLQVFACYAFFVTPSTTDHASGRLPCQSACQEIWKSCRGTAGELFEKRPRLMTCRLYPTENCEGIGYILSECEPAHSAMILKPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914APE3</accession>
    <name>A0A914APE3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038065622.1">
        <property type="nucleotide sequence ID" value="XM_038209694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914APE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209694.1">
        <property type="protein sequence ID" value="XP_038065622.1"/>
        <property type="gene ID" value="LOC119735774"/>
    </dbReference>
    <dbReference type="GeneID" id="119735774"/>
    <dbReference type="OMA" id="KFASEIC"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036744698" description="Receptor protein-tyrosine kinase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="661"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="109448" checksum="F4012DD1D1ECA4AD" modified="2023-02-22" version="1">MTDCNSLNTAFAVLLVSLCGVADVLRLVSGSCQSSVCMNGGSCISYQVSTTATANITQEACLCPEAFTGQHCEESATYIYLEWTAYAVLESEPEIHISVFRFGVLDRFSTVAFQTQSLGAVSGSDFESYFQVITFEPGAHNVNVTIPIIDDFVEEDSESFAVSLKSPSGASLEYPYETAVVHILDDDSMSLQVFPLESTVRVSESVGIIGIELLRSGLIDRVVNVTVSQIPNNSTYALARMADSDLLSDRMQSFRPGEHQLVIFLQINDNDKRQGTREFSLMYRVRQDSLRIDFQDLISIIIDDDENALARPSDSPTVSPGQAYVYFVGLPYITKESDGPLQIPIFRLGDLNVMCEIEIYTSSGTAIDGEDFIGIREIITMDPFAASTTAFIFIYDEPAITEVMDEVFYVTMNVIEGGAPGRPSEQTVAVIIQADITTTATVQFSTASDVALESDGVITISVARQGLLDQQISVVVLTQGATAESSLDFIPMEGVVIFPPQSVLQTLEIEIIDDVEVEDVEWFYVTLGSVSQGMLGTPDRTEIMIIDDDGSAFTVPSSTEFSTTSSPAVQDFILYIIIAVVVVAVLVVIVIIVIFYLRYRRSKERRPRKFDEIPMGSKLSTQKVRSNSYLNRGSPVPIVKGAVVPQREVDPDTKEYPREKLRFYEDVGSGAFATVFRAQAVGIHRPGVVSTVAVKVLKETASESDKSDFLKELAVFKMLDPHPNIMTMLGCCTAVEPLYIILEFMPHGNLQGYLQRIRTGKEKSHPGYLDATQRVIQPEEVLKFASEICRGMEYLASKECIHRDLACRNILLAEDYVCKVSDFGLAREVEGEQQYEMKSKGRVPVRWLAPESLLHNLYTSQSDVWSFGVLMWELVTLGSHPYPGMSSQQVISQVQKGYRLPKPEHCSQEIYDMMVSCWMEDPEKRPTFQGLRFRIEAMLSDAQGYLQMDGFREDDYIYMSVGQVSDDEDRTLTSDNNQVIEEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQT2</accession>
    <name>A0A914AQT2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038066415.1">
        <property type="nucleotide sequence ID" value="XM_038210487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210487.1">
        <property type="protein sequence ID" value="XP_038066415.1"/>
        <property type="gene ID" value="LOC119736471"/>
    </dbReference>
    <dbReference type="GeneID" id="119736471"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="226" mass="25478" checksum="EAE1E0CF2EF3CCC0" modified="2023-02-22" version="1">MQLERPRKHWVSTFLETISALFVVGCLFRTEEIIVGRLEGVIAGNDNCEIVGNWNSPLPWDIKEFEDRLRPGDRLEFHRGVYEHWGIYVGEYEGMKHAVIHFGMFEGGSAFSKKKAFGSSSAASQKPEIRADTIAQILGSCSMKVRINNSRDKEVEPLDLDVIIGVAKIMHRQNTPREYSLFSNNCEHFVNLCRYGEPYSAQAVEAVLTVVFLSLGAIIAFCEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQW6</accession>
    <name>A0A914AQW6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066450.1">
        <property type="nucleotide sequence ID" value="XM_038210522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210522.1">
        <property type="protein sequence ID" value="XP_038066450.1"/>
        <property type="gene ID" value="LOC119736505"/>
    </dbReference>
    <dbReference type="GeneID" id="119736505"/>
    <dbReference type="OMA" id="DEFCYSK"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000130">
        <property type="entry name" value="neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="22285" checksum="53500EB926046CA3" modified="2023-02-22" version="1">MPQQGCSHLACMTLQSKSPVGSQFSTTTNSYLMAKLHRQEVHVLTPYIPDTLATAVVQVFLAQPPNSWSKKCCGVACFVKDNSVRSYFIRVYDIVNGMKLWEQELYHRFKYIVADDQPFFHTFKTDTCWAALDFADDAEAGDFGTAIEAMLRAKIPRKQGKEVNIQPSPTINTTTATTTTTNTATSKKEDKKEKGKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AR74</accession>
    <name>A0A914AR74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066555.1">
        <property type="nucleotide sequence ID" value="XM_038210627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AR74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210627.1">
        <property type="protein sequence ID" value="XP_038066555.1"/>
        <property type="gene ID" value="LOC119736612"/>
    </dbReference>
    <dbReference type="GeneID" id="119736612"/>
    <dbReference type="OrthoDB" id="9983389at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036998520" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="146"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="348" mass="38337" checksum="E06074C8E6386883" modified="2023-02-22" version="1">MTRRVGIRMQRVPSSLLLYCICLGTLVQAITDGALFLERGHRGIVPCPLSKTCKILVVPNVDAMYWYYGSTSDTSLLISYFWGRVAPQNGIPEGVYDIDDECNLIIENVTASNEGAYYFKLKPHLKSMEEGQIEVYDKVSPSHPYPTVIGCDQDQDEDTCEVRVRHDSTVHNLTCVMEQVKPAVELKWFLGGLTELKASTAVRSVFLPANTGSSLRNNTYSTSATIQVPSDYNDIEYVCEAMGVAVGSSSTRTRVRLITQTKPTTATYDEVQSSINPGTTLALIDCIPIPNKPVDSIVILWVLASILLTCIVAAGIYIVCLKKTQSELIRDFRAGTYATVSMSLQDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ASQ8</accession>
    <name>A0A914ASQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066698.1">
        <property type="nucleotide sequence ID" value="XM_038210770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ASQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210770.1">
        <property type="protein sequence ID" value="XP_038066698.1"/>
        <property type="gene ID" value="LOC119736759"/>
    </dbReference>
    <dbReference type="GeneID" id="119736759"/>
    <dbReference type="OMA" id="FHIISTL"/>
    <dbReference type="OrthoDB" id="10048650at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="287" mass="32025" checksum="5CD327AD9DFEF44F" modified="2023-02-22" version="1">MESKHGAENVATSSGHSGQMTAVSIKLPPYWPADPYVWFAQVEAQFTTRHITSEATKYAYIVSALTPEIAQEVRDLLLAPPAENPYKTLREELIKRTSATEQKRLQQLLNDEVLGDRKPTQLLRHMRQLLGERVLEESILRQLFLQRLPPNVQMVLASTGESVKLEPLAELADKIMDVAFQQQPVKVNSVAPVTSACTPAMPAPLTELELLRKEIGQLSLQVQALSRRPRSRSRPRNRSRSQTPTPSTGDSAAADLSSWCWYHASFGDQARKCRQPCQYPGNATASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AW66</accession>
    <name>A0A914AW66_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038067943.1">
        <property type="nucleotide sequence ID" value="XM_038212015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AW66"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212015.1">
        <property type="protein sequence ID" value="XP_038067943.1"/>
        <property type="gene ID" value="LOC119737565"/>
    </dbReference>
    <dbReference type="GeneID" id="119737565"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="101"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="337"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="543" mass="59504" checksum="873AD73AC220D97C" modified="2023-02-22" version="1">MPCPLSKSCNMLVEEVDAMYWRYGSISNTALLISYFLGRVAPQNGIPEGVYDIDNECNLIIENVTASNQGTYYYKLKPHLLGMEVGQIEVCDKVSPRRSYPTVIGCNQDHEVDTCEARVRHDRTMHNLTCVMEQVKPAVELKWFLGGLTELKASSAVRPVVLPANTGLWLRNNTYSTSATIQVPSDYNDIEYVCEAMGVAVLGSSTTRTRVRLTKTKPTTATHDGALLLERGHRGIVPGPNSLTCKLMVEDVDAIYWFYGSLSDTFMLISYFNGRVAPQNGIPEGVYDIDDECNLIIENVTAPNEGTYFFKLKPHLLSMEYGQIEVCDKVAPSRSYPTVIGCNRDHDADTCKVRVRHDSTVHNLTCVMEQVKPAVQLKWFLGGLTELEASTAVRPVVLPANTGSSLRNNTYSTSATIQVPSDDNDIEYVCEATGVAVGSSSTRTRVRLTKTKPTTATYDEVRSSSNPGTTLALTDGIPIPNKPVDSIAIWVVASILLICFVAACVYIVSTVCIIVHVLKKVGAGTWQGLGALLNILSTVHEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXJ6</accession>
    <name>A0A914AXJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068244.1">
        <property type="nucleotide sequence ID" value="XM_038212316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212316.1">
        <property type="protein sequence ID" value="XP_038068244.1"/>
        <property type="gene ID" value="LOC119737752"/>
    </dbReference>
    <dbReference type="GeneID" id="119737752"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037087811" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4 5">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="711" mass="76032" checksum="80F83C531EDE2D13" modified="2023-02-22" version="1">MLPNLKMVCNLLVLLLVVSPLVAHGDESGTGSFGATAGGRARRAVTDLTPEQHQAYVARHNELRGGVSPAASNMEHMVYDALLAATAQEWSQKCDFRHSRDHPSKTLTQTQQYGDNYGENLAVTSSVEQPDVNAILQAWYDEVQFFGYDDLSCASGEQCGHYTQAVWAQSNVVGCGVHHCPDGVTDSDTPTYVFSGVAAWMITCHYAPAGNYQGVKPYISGPSCTKCDSGLGYCINNNCASVSVCADEGGCACRAQCVNCGTLNQAECRCECLSGWSGADCSIECRDTISDCTTVAMFPSVNCPAFNDQCPVACSVCSPPADDACEDPTESTTPSGSNNGGGGTQGGANTDGPAPTAASSTPEPCTLQCANGGSLNSAVCNCTCASGYQGTTCQFRTAQVLYSVVFRVRHDIALFSTVRSALLGSVADALNAYCASSDNYRQCCPDVTDPATNSTELPDFIEESNVLVASGYPTPETSSIYRVGVVALDVQSPLCVALSVGQRKRRSTHQEGSEQRRFRRQSDNYLDQNLLSYAIAGYLTNIRQQLLAVDSTADILSAGPGDTGPTTSPVTTATPTSSNVIIIVAVVAGVAVLLIIFCIFGFACLAGSRQMAGPKYDDPPSYPYEEREPARRRPATLAPEYFDNDPMYHPAGHRYDYVSPAREPVFNDQEYAYAYADAYPEATYERRLGSPQSNLYALDELSPAGRDYYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXV9</accession>
    <name>A0A914AXV9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038068344.1">
        <property type="nucleotide sequence ID" value="XM_038212416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212416.1">
        <property type="protein sequence ID" value="XP_038068344.1"/>
        <property type="gene ID" value="LOC119737802"/>
    </dbReference>
    <dbReference type="GeneID" id="119737802"/>
    <dbReference type="CTD" id="22908"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="121"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="592" mass="68006" checksum="C219B064FD65A403" modified="2023-02-22" version="1">MAVHESLVLYTTDDKFYVEARDDGTKELLVIDRLSQEISLEQSSDQIPPFATSRPICGLMGTIRLLAGPYLVVITKKSKVGEINGQTIWKVTGHELLPYKRTVMHLNEQQQQYNRTYESMINYVLDTNDCFFSTTYDLTHSLQRLYNTSPEFLQMPLFERADQRFVWNGHLLRELASQPELGRFILPVMCGFVSIRIGILHGKRFDYILISRRSCFRAGTRYYMRGLDTEGHVANFVETEQIVQCNGWRGSFVQTRGSIPLYWSQRPNIKYKPKILISQALNHMDGFMRHLDSQVVSYGDQVLVNLIDHRGIEDRLEKTFAKAVIDSGNKSIKYESFDFHHECRKMRWDRLSILMDRLAAPQEKHGCFILSPTSQLLKHQTGVFRTNCMDCLDRTNVVQSLLARRTLQEQLQMFGVLNPGESIDDHLTTAFESTFKNTWADNADFCSKQYAGTGALKTDFTRTGKRTHFGMVKDLYNSMLRYYMNNFVDGYRQDSIDLFLGNHIVEETEGILAPSPLRSKGDAKFLLLPVICIVAFSMVIISILIPAADIYLQLAYVFFWMAATAVCLGLIYLYGLEFVNQPRLAQAKTKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AYL0</accession>
    <name>A0A914AYL0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068758.1">
        <property type="nucleotide sequence ID" value="XM_038212830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AYL0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212830.1">
        <property type="protein sequence ID" value="XP_038068758.1"/>
        <property type="gene ID" value="LOC119738098"/>
    </dbReference>
    <dbReference type="GeneID" id="119738098"/>
    <dbReference type="OMA" id="ACIREDT"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="200" mass="22187" checksum="99CD607BDF518F89" modified="2023-02-22" version="1">MSEIQQTHSKDLLDVGKAGHDDPLLIRKKKPYRMPPSSVLGQVKSFLPKMQEANSQLEERLKTAAPEDLDIENITDCENEVIEMNLAVFAEDDNSSSDDDDNDDYDSERQDGSSDEALPSCGEVTAANIKLPNNTSSRPKRTIIEDLSRVKDNDLRSGVKPDSDKETTVPACIREDTSGQKQDVVADTEIGQSQTFDMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZ23</accession>
    <name>A0A914AZ23_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068957.1">
        <property type="nucleotide sequence ID" value="XM_038213029.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068958.1">
        <property type="nucleotide sequence ID" value="XM_038213030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZ23"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213029.1">
        <property type="protein sequence ID" value="XP_038068957.1"/>
        <property type="gene ID" value="LOC119738238"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213030.1">
        <property type="protein sequence ID" value="XP_038068958.1"/>
        <property type="gene ID" value="LOC119738238"/>
    </dbReference>
    <dbReference type="GeneID" id="119738238"/>
    <dbReference type="OMA" id="RFTWRIA"/>
    <dbReference type="OrthoDB" id="10437613at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="174" mass="18545" checksum="EE97594572A7F7D3" modified="2023-02-22" version="1">MAAVIMTDKMENMRSWFQTIIDGLMVKERLAMAVNFAKERPVAATLIGVAVATSFLPAVAFVSFVVAMLIIGVVALLVVEGTAILMGGGLLLFALFGSMIATVVVGVSILTGLIAGRFTWRITAPLRAKMAERLGMCKGSANVMNSPGTPKEKGQFETDDILDFTSNARKVETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZA7</accession>
    <name>A0A914AZA7_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069495.1">
        <property type="nucleotide sequence ID" value="XM_038213567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213567.1">
        <property type="protein sequence ID" value="XP_038069495.1"/>
        <property type="gene ID" value="LOC119738654"/>
    </dbReference>
    <dbReference type="GeneID" id="119738654"/>
    <dbReference type="OrthoDB" id="10664929at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="271" mass="30093" checksum="AABA6D2442FC7307" modified="2023-02-22" version="1">MHDLLDHPEVWSRLAVGVVGEMCGGHPAYSPVLMLRENGGECLPLQVFADGKSLNSGSLLKLEPTQARLIPTAHDRKFGPIRNALRAIRQSFSGRGLHSVPTDEIAILEETCPLSGPDSFEFLQISRCFQQPVGGDKSSRKGGRQTELKLGIYNVRTRRVDPRKLLGCCVDPASPVAKLKKRKFFMVYETYVAGEVTLSARARAHRARRGVPTGDITLSTKRDCPVCFRCVEVILSRSGIVKNLRFDVRLRELSTIKDQAVLPTMKILMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AZT6</accession>
    <name>A0A914AZT6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interferon-related developmental regulator 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069222.1">
        <property type="nucleotide sequence ID" value="XM_038213294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AZT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213294.1">
        <property type="protein sequence ID" value="XP_038069222.1"/>
        <property type="gene ID" value="LOC119738407"/>
    </dbReference>
    <dbReference type="GeneID" id="119738407"/>
    <dbReference type="OMA" id="HISGRHI"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
        <property type="entry name" value="IFRD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="3">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47105" checksum="B2DC6AB8E3600C5D" modified="2023-02-22" version="1">MPRRKVRKKGAARGGDSSEGDTEETGSIVSSHLSEPDSILEEEPQQGDNVDETDAQDVLEEKIKELIDGTTQKSANGRKDCLEGLKKALARKVLTDFIENRKVTISDCVERCIKKGKSDEQALAASVGTLLLIQLGAGDDSEGIFNDLRHLLKTTLLDKTAAPKGRASCALFLGLGCFLAAEDYETVMECMTALEHVFSLSYLKGDGTAPSHTPAIAALHCAALSAWTLLLSIAPPSRVPQLVDSHLGKLPSLLHSDDVSLRIEAGESIAMFHELAREQNEDFDMENVEELVVTLRGLATDSNKYRAKKDRRQQRSSFRDIIRTIQENEIPHEIIKFGPEILELDGWVKKRQYVAFREVLGSGTNIHLQENVLLRDIFGLGAPIIMSGPGAPKKANRFERHHYNSQAFKARTKVRSKQRDKRTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0K3</accession>
    <name>A0A914B0K3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069304.1">
        <property type="nucleotide sequence ID" value="XM_038213376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0K3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213376.1">
        <property type="protein sequence ID" value="XP_038069304.1"/>
        <property type="gene ID" value="LOC119738472"/>
    </dbReference>
    <dbReference type="GeneID" id="119738472"/>
    <dbReference type="OMA" id="CPEMACE"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59931" checksum="6E6CE127C7A9C9D1" modified="2023-02-22" version="1">MTITDKVISVLANTYYISTVPFLLCAVVTFLVTTLIWRRLTYWSKYTWPPGPRGWPLVGNSPLIAPNSGQTNANITRIGKQYHPDMFTLTLYLGKRMLILNSFESIKDAFVKHSALVSDRPSVWPFTYVNENQRNVGVFFEDFTESWKREKKYMMRTVRQFGYGTSGSESIILQEANHLAELIKKRGGEPFELGLPLSLCLLNVTFSMILGTTYEEDDKEFSKILSYVLEWFLEIFKLYDVEPMLPFYHKFGLSPRLNKGKMMTKDLLAFVQKHIHNHKATLDPGHPRDMVDACLIEMAKGDPNSDLREFTDEKFLWMLFFFIPDQGDTASGLFLFLMLATALHPEVQQRVFQEIQDVIGDQPPSLKDKEKMPYTEAVILETLRMDTTFWLIIPHVTADDVEILGYKIPKGTTVIPNIYAVHFDPELWGDPENFRPERFIDEQGRINRPDYFIPYSTGRRACIGEQLSQKQFFLFYITLIQKYKFKLPDGDPIPKLESQWLWVSPPDYRLQAEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0Z0</accession>
    <name>A0A914B0Z0_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069443.1">
        <property type="nucleotide sequence ID" value="XM_038213515.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038069444.1">
        <property type="nucleotide sequence ID" value="XM_038213516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213515.1">
        <property type="protein sequence ID" value="XP_038069443.1"/>
        <property type="gene ID" value="LOC119738609"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038213516.1">
        <property type="protein sequence ID" value="XP_038069444.1"/>
        <property type="gene ID" value="LOC119738609"/>
    </dbReference>
    <dbReference type="GeneID" id="119738609"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="199" mass="21343" checksum="4EE779A4891C8CEC" modified="2023-02-22" version="1">MVTAHPHGHIPRPPSTAKKIPHSTSEPPVGVTQDLPSPSQGPLTRLADTPTPAPTPAPDPTHGFVASFSFVGTMLLICGTILILISSPSQRAYPSHRDSKTSTVTNDGTSPGIQTVFPGVTVGIALLCLGIFAYVTAVTIYFKGNCLHQATENEVSQRNIDGGLSPRHVPAVQATPLRRPYMEFRVVLVPLRSYQEYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B299</accession>
    <name>A0A914B299_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070137.1">
        <property type="nucleotide sequence ID" value="XM_038214209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B299"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214209.1">
        <property type="protein sequence ID" value="XP_038070137.1"/>
        <property type="gene ID" value="LOC119739324"/>
    </dbReference>
    <dbReference type="GeneID" id="119739324"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="95" mass="10994" checksum="AEC8235A0236BB8A" modified="2023-02-22" version="1">MAATMANATRATVLKLYREILRESKKFTGYNYREYALRRTKVAFRENKSLTDEAKIKALIQEAEENLQIIKRQVVLSQLYKDPSLVIEGENAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2E9</accession>
    <name>A0A914B2E9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038070093.1">
        <property type="nucleotide sequence ID" value="XM_038214165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2E9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214165.1">
        <property type="protein sequence ID" value="XP_038070093.1"/>
        <property type="gene ID" value="LOC119739287"/>
    </dbReference>
    <dbReference type="GeneID" id="119739287"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF420">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="105"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="391" mass="44641" checksum="E86EDF51D1A66A8E" modified="2023-02-22" version="1">MKLLRNISRGPLSPGNGQWRNFSEENPHFSNDWVSPFGNGQQHQRPPFWNERGGNFSEFGNWRDGNGSQLEQGSCRQFDNLHDLEIFTAIKYALLLPLSILLAAIDLYIIFAICRNRNLRSISNYFLANLLASELVYKLLMCFNNELLVSPDGCVQCENSYLYVFALTSMHLIYFLSGICVAVDKYIKITRPLRYAAMVTRRVCIVVVTIAWVSALAGGGLASLLFQYLVGCTTPRALQSHLQTTMLFLSDGIVLPMVMIIMCLNIKIICIARHQARAIANMAPQHHANSDNRNDTSDQQQQAVRKSTRYFKAFLWSFVLVWVPSVMVTNICYILPFSRGNLSWFIGIRNAMNVLGLCQMLYGTVVLTLKQEQFRELWRGHWQTIKQKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2F8</accession>
    <name>A0A914B2F8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein naked cuticle homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Cell autonomous antagonist of the canonical Wnt signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NKD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070197.1">
        <property type="nucleotide sequence ID" value="XM_038214269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2F8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214269.1">
        <property type="protein sequence ID" value="XP_038070197.1"/>
        <property type="gene ID" value="LOC119739360"/>
    </dbReference>
    <dbReference type="GeneID" id="119739360"/>
    <dbReference type="OMA" id="RQEHHGK"/>
    <dbReference type="OrthoDB" id="5953812at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040140">
        <property type="entry name" value="Nkd-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22611:SF9">
        <property type="entry name" value="PROTEIN NAKED CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="587" mass="65046" checksum="5F9211F174C77051" modified="2023-02-22" version="1">MGKTQSKNIGFSNLGFASASTKRRENPEGGYVLSGCVNNQFQESEESLWHSKVALLGSSDSSEKRSFQLSPVPTTSSDDPHLCQCNTPHVPVGFAKDNCHFEVALPPEVTGSACSVKVVAVEKTDSTEEVKPPLSPTMSSNSGKATVGAVDCDVSLDGESDQQEWAFTLYDFDGHRKVTREDLSSLLKTISEALASTITLPASGSKKLRLRLSVGSEDSGDPKPFPAENKENVGRTACPVSTGPGKPLHDVDGLPTPAGYQQPVRSGVRTHRHNRRTLSASQADYHGMDGRSPNTKRQHKLRRQQSAYNHGGDEEVRHRPHPVSSSSSPTREPENRERRNYYEELAGIENDCNQQEEAIVIAQEREVEYLAQQQLPLPHRTRHTSAERLRGRGHRHPSKGGKGGHRRSRSYDLDAQQPIQEGVLSTEEHKLKCGLRQRYHKDYHMLLLEASRAKLEGFQPASPPGPAGDNQTPQVPMKLPTFTAAPSPLARLATFAPPAPSPTNLCPTQLNSSPAPRDPALVTSPKVPTRRRSHKKLRKPALQPFTYMQHEIANGMEGVVYVPVSQRHEHHHHHEHHHHHHYHHYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4B5</accession>
    <name>A0A914B4B5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071131.1">
        <property type="nucleotide sequence ID" value="XM_038215203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4B5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215203.1">
        <property type="protein sequence ID" value="XP_038071131.1"/>
        <property type="gene ID" value="LOC119740014"/>
    </dbReference>
    <dbReference type="GeneID" id="119740014"/>
    <dbReference type="OMA" id="WHAIDIL"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="179"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="577" mass="63883" checksum="C7AFA0E3A9B8E32F" modified="2023-02-22" version="1">MVGPESTATPWVGMGSPGTWDSWTGNLASTSGDYLTDNTVDSTTTSSLTTTYIQDITSDRTQTLWSTVTQRQSTIASTTHEEFFTGSTAISTVYATTDNTLISSVTSATSSNPYDSGTTIDEFQSTMMDSTSFVGTTWLNNSASMVDIVTSETPIEDTLARDIIVGVLLSSLGLLTVFGNTLVILAIYRERCLRTVTNFFIASLASADFIIGTTVIPFAIYNELRFGQWVFGKPWCDMWHAIDILACTASITNLCVIAVDRYWAITRPMSYPSKMTKKLGTLLVAFVWICSSLISFPCIAWWHAVEPADRPDTDCVFPEDATYLIISSCISFYIPSAMMIFMYAQVYRTAVEQVKVIKSGQRKVHAGPQQGAMSMRVHRGGTMNNNHAAGYTNGYNARNVGVTGGAHGGAKNAVSNARRSLLAGMNREHKAARTLGIVMGVFIMCWLPFFICNVMAPVCPQCIVNPHITFPVVTWLGYANSALNPAIYAFTSRKFKRAFIKIICDCLPRRYQPDKWERRRRPRRTMSMSNMEQDSSYTMVEYGDSLVRSPDRIKIDSSTAILSGGRPHLYSLRQTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4V1</accession>
    <name>A0A914B4V1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070969.1">
        <property type="nucleotide sequence ID" value="XM_038215041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4V1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215041.1">
        <property type="protein sequence ID" value="XP_038070969.1"/>
        <property type="gene ID" value="LOC119739909"/>
    </dbReference>
    <dbReference type="GeneID" id="119739909"/>
    <dbReference type="CTD" id="79892"/>
    <dbReference type="OMA" id="EEHTEMI"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="682" mass="75853" checksum="952CDF4A228C5CA7" modified="2023-02-22" version="1">MPSVCRSSLSSRAIFALFKFVGAAEKYNRSASSFALFALVLKGKEDIFTMPGVEDWLNRPLDIVQGLFDINNKKCSEKVTEYFSKKLEDKDSLEWVPSLNHTSLHLLKPNTVVRFRCMIQDMYDPEFYLGAYEVVDKSSGQVTMKSGMFQDLAECSQNQRLNLESSKNVTLDRQTFYCVPVPAETEWVKQAFTEHSCCQTSDPSTSQSSRVKRALEVDDLTPSTSQLPVPSQTGDHGADVSMETTDGNQSEKRSRMSEVTSQRSTTSVDLNFPLSGEKGPACMVKVYDNFESFRLNDVIEFIGVLSVDPELANVPACNHNGGTSSAIDGADLMEGIEEQAAHSPPPSLVPRLHAIVSHKLQHINPLLPVSLESDEGKTFVQGMMGDLGSVRDQLRCLLQQLLLGDALAADYLLLNLVSSVYARRDVIALGKFTLNLIGCQESGFSQTLQGLLSQLVTKSHLLPLSLENMNSLRLTPKKDYTANRLRSGVLQLSDRTHVLLDETALQPGQLDANGVRNLAAIGNAISWQKVDYDFEFHKTEFKTNLVFLVVSEGKSMLPSDSQIPIQPKVLPMSDAGIQTGIQRMISSGSVNLNRIRTYLGVIPFIQYNLSEEMSKIVEQDFVDARKADPSQMTQEDFHSLLVVARLLSVSIGQTSLTREVWERTKRMEQERKLRLKNTASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B609</accession>
    <name>A0A914B609_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MARCHF5</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING finger protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Membrane-associated RING-CH protein V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase MARCHF5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038070901.1">
        <property type="nucleotide sequence ID" value="XM_038214973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070902.1">
        <property type="nucleotide sequence ID" value="XM_038214974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B609"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214973.1">
        <property type="protein sequence ID" value="XP_038070901.1"/>
        <property type="gene ID" value="LOC119739863"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214974.1">
        <property type="protein sequence ID" value="XP_038070902.1"/>
        <property type="gene ID" value="LOC119739863"/>
    </dbReference>
    <dbReference type="GeneID" id="119739863"/>
    <dbReference type="CTD" id="54708"/>
    <dbReference type="OMA" id="KRYCWVC"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16701">
        <property type="entry name" value="RING_CH-C4HC3_MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000262">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="21">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="300" mass="33929" checksum="CB29C21AFF5E5ACB" modified="2023-02-22" version="1">MSGDETGAGDEECRKMPSTRSRSIDDRKTCWVCFATEDDDRLARWTKPCRCRGTTKWVHQICLQRWIDEKQRGNSTVKVSCPQCNTEYIIIYPDLGSMVYILDVLDRLIYKVCPFAAGGIVVGSVYWSAVTYGAVTVMQVLGHKEGLDVMERADPLFLLIGLPTIPVMLILSKMIRWEDYILRLWRKHSPKLPFWSYFFPELGGGSVLPRVPTELMPMADPISATRVLCGALIFPTIATMCGKLMFGSLHSNLQRTVLGGIAFVTIKGALKVFYKQHQYLRQAHRTIQDFPEEKAQGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B844</accession>
    <name>A0A914B844_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072154.1">
        <property type="nucleotide sequence ID" value="XM_038216226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B844"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216226.1">
        <property type="protein sequence ID" value="XP_038072154.1"/>
        <property type="gene ID" value="LOC119740772"/>
    </dbReference>
    <dbReference type="GeneID" id="119740772"/>
    <dbReference type="OMA" id="ETIDIRY"/>
    <dbReference type="OrthoDB" id="8887147at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21316" checksum="D2222F780055EFEA" modified="2023-02-22" version="1">MTDTKANLQAKVQRRIVVTLIFGTSIAYIAWVYYPFDAPKDPTLVNRLVFTLRWLVLSMLPIIFGVKLVADVRFHNMDTAGVMTTTQYAEQLVRLKQRALQNTLEQTALHVPIMLIFSTYVDSNHLKLVPIVICMFNLGRIIFFIGYLATGDQFNRAFGFVLTFFSNVIPVVYCLYRLFVSGASYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8Q1</accession>
    <name>A0A914B8Q1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071797.1">
        <property type="nucleotide sequence ID" value="XM_038215869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8Q1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215869.1">
        <property type="protein sequence ID" value="XP_038071797.1"/>
        <property type="gene ID" value="LOC119740529"/>
    </dbReference>
    <dbReference type="GeneID" id="119740529"/>
    <dbReference type="OMA" id="CVIFTAM"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038078858" description="Spondin-1" evidence="13">
        <location>
            <begin position="26"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="14">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="15">
        <location>
            <begin position="188"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="658" mass="72089" checksum="0B399181A6CBF1C8" modified="2023-02-22" version="1">MARIFTKMFTILSFYSLTLLAGTLGASRRACSRLPGDFTVPKRPGDNGYRIRISGHPSFYVPGQEYLVTLSSTPPVSFREFTFACLLVEDDATSAGHFEIVDDRLAQFSPDTINCPELLIHTSKASKTSVTFRWIAPPAGTGCVNFKAAAVQKKQIWYKDERGLTLWLCEEDVAASVPPQTNTVDEDANIECCACHTAKYTVTMRGLWSQETHPKDFPGGHGDHWSDLIGASHTKDYTIWKYGGYASLGVQRVAEWGSPTTLEREILAQTRNIKTVIRSRGLWPARGNMSAVLSVNRTHNLVSTLSMIGPSPDWCVGVSRVNLCTADCDWLQRLEIDLLPWDAGTDSGITFRSDNAPTVPIEPIHPITSSFPSNPLGAFYDPMGRPIPPMAILVFERTDNTLYDDLGEVVCEVDVGGPDATHTGGGGMPPKEGMMPPKEGMMPPKAGTMMPPKEGMMPPKAGTMMPPKEGMMPPKEGMIPSPDGEIMPPKPGMMNKGGELSNVTTPMMKKPVPEGDITMPPKVMPNEGEDIPVTMPPKHAKTGGRQPIDCMMSPWSDWTECSRSCGKGTMRRQRMVKQKARHGGQACGKQKEKKNCSTGPCPRDCMMSDWGEWTPCSVTCGNDGTQIRMRKIKKKARGSGQPCGPRREERVCGTPIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BBJ5</accession>
    <name>A0A914BBJ5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038073598.1">
        <property type="nucleotide sequence ID" value="XM_038217670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BBJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217670.1">
        <property type="protein sequence ID" value="XP_038073598.1"/>
        <property type="gene ID" value="LOC119741774"/>
    </dbReference>
    <dbReference type="GeneID" id="119741774"/>
    <dbReference type="OMA" id="LRWAWRI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20613">
        <property type="entry name" value="CYP46A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038073598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="60343" checksum="12F087E5374C1AA5" modified="2023-02-22" version="1">MAEASILYRITVFLAALVPAVFLIGFVGFVLYLFYQHKRFAHFPGPPRSDFFTGHVRQMIDRINTGSSLAEYLTDQMRVYGQVYHLFMFHKPVVVVLEPNFLKEVMHSTTHTKPPEEASTFWYVFGQRFLYHGLLTETDIPKYLKRRALFSPAFHRSYLMNLMGSFNESTDILINKLAEKADGKTTVYMLDELNQVTLDVIAKVAFGLHLNKTADSGFSFTTAVKTSLEGVMATFLQPWIKYSFLPSHRQFRQKVRDSIHHLRETGRKCVQGRLEAKKRGEKLPNDILTYILDASNDLQADADFRMEEMLDEFVTFFLAGQEETTNLMAFMLHELGHHPEIMHRVVTEVNAVLGDRDYVEYADLAKFEYLSQVIKETLRLWPPAFGTNRLMASDVTVQGLKIPAGTVVWLNTYVMGRMESHFKNPLVFDPDRFHKSGSEDRPLYAYFPFSMGTRSCLGQPFALIEARLIVARLLHKFEFKLCPGQPRGDIVQHASLQLRDRCMNYLHLSNIRIFPACYYVCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BF58</accession>
    <name>A0A914BF58_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038074883.1">
        <property type="nucleotide sequence ID" value="XM_038218955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BF58"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218955.1">
        <property type="protein sequence ID" value="XP_038074883.1"/>
        <property type="gene ID" value="LOC119742782"/>
    </dbReference>
    <dbReference type="GeneID" id="119742782"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="130"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="211"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="295"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="467"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="632" mass="66998" checksum="8FB816E76F56797F" modified="2023-02-22" version="1">MVVLVGTPEVPVYARKFQALVFDGSSCPPPEANTGNDNNTILAYLPSNVSVAPIYWTNPVLESPPASTLEYIFCEPDPNMDIDIYCRSGDEFPVTYNNDNDGRIKVIYQLVDPTPPDFENGDCVFYIRILDKDAPTITCPRPSNVNENTDAGATTYTLVYSAPEVADNSEGVVWSSDITNGTALSIGPHVVTFTATDTSGNTAECSFTVTVEDSEPPELDCLDSFSITTAVGQPYGVASWVIPTATDNSGDAPVQTANLTSPANLGIGIHTVTYDATDGSDNTASCTFQITVTDEEAPDLSCLTSFSIETVFGLPYGTATWMIPTASDNSGETPVQTANQTSPVNLEIGTYTVTYDATDASGNSAECSFKITVVEGIPLSVTCTPFSLTTDSNKAHATYTLPLNPDVIEHNSGSYTVETTVTTQDGTPVSHTDGQSAQFSYDEVYSVQYCVQDSTTTECCTSQLAVQDDEDPVITCPAAFETATDAGVAYYNESLPAATVTDNSGEDIMYIPEDGPYPLGTNTVTYTATDSSRNSASCTVEVTVKDEERPTILTCIDSIGTTNMGSGVATASYELPTGIDNSGLEVTVQCTPVLGTLLPLGTHTVTCVFRDQAVPVNINLCFITVTVGGYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFG8</accession>
    <name>A0A914BFG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074676.1">
        <property type="nucleotide sequence ID" value="XM_038218748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218748.1">
        <property type="protein sequence ID" value="XP_038074676.1"/>
        <property type="gene ID" value="LOC119742621"/>
    </dbReference>
    <dbReference type="GeneID" id="119742621"/>
    <dbReference type="OMA" id="MDANIPI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21920" checksum="07BA0C9FED766B5D" modified="2023-02-22" version="1">MGSFFSRRIRDIQNYFSSRVHHRILMLGLDAAGKTTVLYRLKENITVNVIPTIGFNVETVHPAPGLALDMWDVGGGDKIRPLKRHYKRSGVLLVVDSTDHERFDEAREELVMILNDSHVGLPVVILANKQDLPNAVSPSQLCDALRLTDLPKGYPWQIVGTSAINGDGLQEAAISLGKMVKKYKKDNRHLRKDSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFJ2</accession>
    <name>A0A914BFJ2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maintenance of the Golgi structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038074630.1">
        <property type="nucleotide sequence ID" value="XM_038218702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BFJ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038218702.1">
        <property type="protein sequence ID" value="XP_038074630.1"/>
        <property type="gene ID" value="LOC119742593"/>
    </dbReference>
    <dbReference type="GeneID" id="119742593"/>
    <dbReference type="CTD" id="84272"/>
    <dbReference type="OMA" id="SWIITMW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF7">
        <property type="entry name" value="PROTEIN YIPF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="10">
        <location>
            <begin position="163"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="301" mass="32739" checksum="4AA74D8226B60A52" modified="2023-02-22" version="1">MDTQKTNPLYSSPYGGVPTFSSGALPTTFSPSGMAASAAPTAPTISTSTAAASTSQTWQNDFEFVSDDDLTSASEAPTGQTGDVQLDMGDMQYTDATSTDFKAQSGSSASQFLQNKGYGWLLEVEDVDDDNKPLLEELDIDLKDIYYKVRCVVFPCPFLGFQRQILRESPDFWGPLLVVLLFSAVSLYGQFRVVSWIITIWILGSLIIFLLARVLGGEVNYSQCLGVIGYSLLPLIITATTLPLLGTIPYVGFVAKFAGVLWAAYSAGSLLIQDSLAHKKPLLIYPVLLLYIYFFSLYTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BFK8</accession>
    <name>A0A914BFK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038074864.1">
        <property type="nucleotide sequence ID" value="XM_038218936.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038218936.1">
        <property type="protein sequence ID" value="XP_038074864.1"/>
        <property type="gene ID" value="LOC119742765"/>
    </dbReference>
    <dbReference type="GeneID" id="119742765"/>
    <dbReference type="CTD" id="150962"/>
    <dbReference type="OMA" id="LVISCQR"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="9">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="10">
        <location>
            <begin position="290"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038074864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="548" mass="62166" checksum="4F9BDA00C47C7D5F" modified="2023-02-22" version="1">MYPMTAQIELLTTWKGQWPNVQTXFELEECQTVISELQRCGCCDRCILRLIGAKRQSSYNNPQEVLTQLQATKENGSTPCQETKDEPPKSDGKAQVSTNQTTGVCSVCLGILQGLCEKSHVLDMARQVQEADFGFENFTMSMTLPLQLLIREQCIFLHLKSVFSKLYQKSAHRIIATIKEVYKWVCGPVMGDALDVSFYYKSPMEVMVTFTHQETEEELDKLLQQTQDSEPPNKRKRFYASAANAPGKPVVLATIKKLPNNRFKELFPCPPSVPRSPCATEVACWYSAVFVAGRYNKYSRQLSQTPWLIDGERKTESSMQEILCDPIKELFKASDFKFSASGREDVDVRTLGNGRPFIVEILNSRRPIPPQEELTALQKSINRSTQDARVRDLQCIDREDTNKLKDGEEIKTKSYSALIWSSDEQTEESLAFLADIKELVLHQKTPVRVLHRRPLATRDRIVHNMSATVIDAHHFRLFLKTQAGTYIKEFVHSDFGRTKPSLGTLLKCDVDILELDVESVDLDWPPSLPDDDVSDDNNKKQPAGDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BI80</accession>
    <name>A0A914BI80_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038075605.1">
        <property type="nucleotide sequence ID" value="XM_038219677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BI80"/>
    <dbReference type="EnsemblMetazoa" id="XM_038219677.1">
        <property type="protein sequence ID" value="XP_038075605.1"/>
        <property type="gene ID" value="LOC119743274"/>
    </dbReference>
    <dbReference type="GeneID" id="119743274"/>
    <dbReference type="OMA" id="VCMISVA"/>
    <dbReference type="OrthoDB" id="10169404at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038075605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49048" checksum="5D1689C207B1EB26" modified="2023-02-22" version="1">MADISGKTKWLRIATSIGALYLDSCLHGAVVPIVAEWDWAATDVPLTTNRSQTNGNEETRASFAIGAIFLSTGLAEIGLSPIAGMTADRFGFDVVILIGLLIGILKCLLFGLLGTSIVIVSTNRVLQGALSACTQTIAMARIRDVYAKASPECANVMAIALCKMAFNFFAGLVIGELYGYLKYRVFLLFLPISLLLIIGVLITFRNDNFHSKDESNGKDECEQNSSGAVRWRVICDVQLMIVTTCCMFSTLGQSSLEPSFAVWMKSSFEAGPESTGVILGLCGVASITSSLASAQILPALQHRSWIFCMASLCTAGVPLLLVNFSPNIVVAGVALCTHLFGATAARFTLLMMCSTIANSRYPQSYGLVFAMFNVGWAASFLLGPLLASYLFGSVCVICIIGAACIASSLLTVILQTLDSKQGPNIMDCFPNDYPKYQIVTSTGGPPLSYEEEIQQPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BJQ8</accession>
    <name>A0A914BJQ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076051.1">
        <property type="nucleotide sequence ID" value="XM_038220123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076052.1">
        <property type="nucleotide sequence ID" value="XM_038220124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BJQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220123.1">
        <property type="protein sequence ID" value="XP_038076051.1"/>
        <property type="gene ID" value="LOC119744265"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220124.1">
        <property type="protein sequence ID" value="XP_038076052.1"/>
        <property type="gene ID" value="LOC119744265"/>
    </dbReference>
    <dbReference type="GeneID" id="119744265"/>
    <dbReference type="OMA" id="QDNRVNG"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="381" mass="41922" checksum="966033412D7559F8" modified="2023-02-22" version="1">MGAFLDKPKMEKENEIGCGNGLRFALCSMQGWRVEMEDAHTAVIGLPFGLKDWSFFAVYDGHAGSKVAKYCAKNLLEEITSNKEFKGSDKPGPGFHPTEDNVKMGLRTGFLNIDKKMRDILARDNDKSGSTAVGCIISPKHIFFANCGDSRAVLSRSGGVCFSTEDHKPSKQNEKNRIEKAGGTVMIQRVNGSLAVSRALGDYEYKSNFGMGSTEQLVSPEPDIKVIPRQADDEFIVLACDGVWDVMSNDEVCHFIRSRLELTDNLKEVCNMVVDTCLCKGSRDNMSIIIVTFENAPKVSDQALSKEAELDQLLEAKTKEIMDSFGERVGIDLVMHVMTTTEIEGLPPGGGIQAKKSTIEAIVNRLNSDQKQDEEASDDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BKH3</accession>
    <name>A0A914BKH3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038076420.1">
        <property type="nucleotide sequence ID" value="XM_038220492.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038076426.1">
        <property type="nucleotide sequence ID" value="XM_038220498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BKH3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220492.1">
        <property type="protein sequence ID" value="XP_038076420.1"/>
        <property type="gene ID" value="LOC119744531"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038220498.1">
        <property type="protein sequence ID" value="XP_038076426.1"/>
        <property type="gene ID" value="LOC119744531"/>
    </dbReference>
    <dbReference type="GeneID" id="119744531"/>
    <dbReference type="OMA" id="KMAQFAV"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09032">
        <property type="entry name" value="KH-I_N4BP1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056629">
        <property type="entry name" value="KH_N4BP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23050">
        <property type="entry name" value="KH_N4BP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N4BP1 first type I KH-domain" evidence="13">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rege-1 UBA-like" evidence="12">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="11">
        <location>
            <begin position="375"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="111285" checksum="8513A1EE5F989CB5" modified="2023-02-22" version="1">MTPGKLCTSEKYHQDREDYFRLAKVDILSLTDARTSGRMAQFAVSRAHRKLVESHRPRIEDKFRVAIQLSSYAEPEQAGRTVRGDGGLDQPDSVIHVDRLSPTDNVSDQVWVEIEGDSTGTVQAKEYILSLCHGSDEPRFEEKLPYGFGDLLQAKLEDIAVETRTKIELDRDTVILRGDEMNVAMAQSLIDQLCTDLKQHKESSLFSEERQTFVRSPQHNSTNEGFDSVDSSCSQFTLQDDWTIAADSFSSSHAISNSSVMGRPVEEQRSPRLIPRSVVASQSVETTHPKDSKTISLTNSMQKLGFRKEQVDLVLQQLGPDADHNDVLGALVNQRPTKTDLEEAEDSGKEEIGGSRDMSDGLPSVDAPEDESNNLRPIIIDGSNVAMSFGNKDVFACKGIEIVVNWFCERGHMKIYVFVPAWRKEASKPETPITDQGILNDLEKRNFLVWTPSRRINGRRIVCYDDRYIVKTAVQEDGIIVSNDNFRDIQNEKPEYRKVIEERLLMYSFVNDQFMPPDDPLGRHGPSLDNFLRMKPTMPDHLPQACPYGKKCTYGNKCKYYHADRPNRPMKSISETLKERDKTRKEKAKLNSDRSHSPRFTSVSSAPIPGYVPPEEIAPSPEWHTTPLPGPSTQQSSPKRGSRIASESSALQTSPKSSGSPRHFQTVESPSHSPYPTTRDETFGIPDLQPYQHGAGVPHLHSQVPSQTLNTPPFGRANHTSPLPSFCQHTDRQNQRDMYTVPLQGYPSVNPSDRGYAQMEESLNRNRMSMPPVMYGSGEPMGVTPSGMGFERRSSHNDLMTDFQRMGIHDTSGVALPREPQPNYGYRQSPRQYHNGEALPGPPQPLPSHHLGEISQGASQPMTYHSTEAFIPQHGMPPSLSSDQMLYHPSRHTPPPRYHPQSEPPQPRPYYPSPGPMPVTSTWHSSGRPTPDNVSPRRNSEPAKSLEEQRKYILSNLASRFGHDKVNAVMQRHPHETNPGKLIMYMNTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BL71</accession>
    <name>A0A914BL71_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L37a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038077038.1">
        <property type="nucleotide sequence ID" value="XM_038221110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BL71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221110.1">
        <property type="protein sequence ID" value="XP_038077038.1"/>
        <property type="gene ID" value="LOC119744911"/>
    </dbReference>
    <dbReference type="GeneID" id="119744911"/>
    <dbReference type="CTD" id="6168"/>
    <dbReference type="OMA" id="EAMKRTC"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12561" checksum="CECB53A16A93F134" modified="2023-02-22" version="1">MTPDLGLPSSPLPLPSWLEIIMAKRTKKVGITGKYGTRYGASLRKMVKKIEISQHGKYTCVFCGKDAMRRKCVGIWHCKACRKVVAGGAWVYSTSAAATVRSAVRRLREMKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BLV2</accession>
    <name>A0A914BLV2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038076447.1">
        <property type="nucleotide sequence ID" value="XM_038220519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BLV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038220519.1">
        <property type="protein sequence ID" value="XP_038076447.1"/>
        <property type="gene ID" value="LOC119744546"/>
    </dbReference>
    <dbReference type="GeneID" id="119744546"/>
    <dbReference type="OMA" id="DEPYRIC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037505447" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038076447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="165" mass="18774" checksum="655139874E7A41C8" modified="2023-02-22" version="1">MKWPLVTSLLVIGITVANGYWGSHSSDDPSYANLGFYILDMNCNDAGTYCQKCYIAHSEWNVAHMHVFQFTKDPVQYKFRCIEGNQDWEILIIQADLDEPYRICAAWGNYTMDAQLARINVCVDNTFEGVEVPPECPRPIFVVSLDYHVADKTVRGEQNLLCVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BMP8</accession>
    <name>A0A914BMP8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038064668.1">
        <property type="nucleotide sequence ID" value="XM_038208740.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038077394.1">
        <property type="nucleotide sequence ID" value="XM_038221466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BMP8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208740.1">
        <property type="protein sequence ID" value="XP_038064668.1"/>
        <property type="gene ID" value="LOC119735049"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038221466.1">
        <property type="protein sequence ID" value="XP_038077394.1"/>
        <property type="gene ID" value="LOC119745242"/>
    </dbReference>
    <dbReference type="GeneID" id="119735049"/>
    <dbReference type="GeneID" id="119745242"/>
    <dbReference type="OMA" id="QPEIFFY"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18948" checksum="CBACD82F60719254" modified="2023-02-22" version="1">MFETFNTPAMYVGIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDVKEKLCFVALDFEQEMATAASSSALEKSYELPDGQVITIGNERFRCPEVMFQPAFIGNTISKWFFFVCFIGCFGKYAETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BNN9</accession>
    <name>A0A914BNN9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038077102.1">
        <property type="nucleotide sequence ID" value="XM_038221174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BNN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038221174.1">
        <property type="protein sequence ID" value="XP_038077102.1"/>
        <property type="gene ID" value="LOC119744951"/>
    </dbReference>
    <dbReference type="GeneID" id="119744951"/>
    <dbReference type="OMA" id="RNASACG"/>
    <dbReference type="OrthoDB" id="6503655at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038077102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="341" mass="38218" checksum="6D4703FC2162E539" modified="2023-02-22" version="1">MASSRDSTELMIQNVSSCITDVTPLLEDDYLDSESSTYNPIQTALRTSFIVLNSLMVIIGNIFSLTVMRYVDSPRFPPSSKAFLCNVIVWDLAHGIFSILYVPPAALNYWPYGQFLCEASGFVLMFINFCCVNAAILITVDRLLAVLYPLRHPIMISTKRALAIIAIAVLFALSASIATFAVSADVAYSNDTVTCFVQWSRVSPANLFRLIVCIGCLLFLPAVILVGCYTKLYLVARKHAKRLAKLRRNASACGRNPGLTVTNSRALRMCLLITATFCIAWTPYAIVSTLNYVTGEDTHPLVDFITCWLCLCNSWWDVIIYFFMAQEFRKTARKLLCRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRU7</accession>
    <name>A0A914BRU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038078338.1">
        <property type="nucleotide sequence ID" value="XM_038222410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078339.1">
        <property type="nucleotide sequence ID" value="XM_038222411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078340.1">
        <property type="nucleotide sequence ID" value="XM_038222412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038078341.1">
        <property type="nucleotide sequence ID" value="XM_038222413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038222410.1">
        <property type="protein sequence ID" value="XP_038078338.1"/>
        <property type="gene ID" value="LOC119745802"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222411.1">
        <property type="protein sequence ID" value="XP_038078339.1"/>
        <property type="gene ID" value="LOC119745802"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222412.1">
        <property type="protein sequence ID" value="XP_038078340.1"/>
        <property type="gene ID" value="LOC119745802"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038222413.1">
        <property type="protein sequence ID" value="XP_038078341.1"/>
        <property type="gene ID" value="LOC119745802"/>
    </dbReference>
    <dbReference type="GeneID" id="119745802"/>
    <dbReference type="OMA" id="FWYHRIC"/>
    <dbReference type="OrthoDB" id="270215at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15551">
        <property type="entry name" value="PHD_PYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="238" mass="26113" checksum="24B150B87377350C" modified="2023-02-22" version="1">MPREKKQSKAKRFRASSDSDLVSQTESEHSNTSEPSSPRKKHKKASAKQAAASGSTPDLPQALLPPQPLHASHISAANPFDDTPNPVPRPSHPGFMARRMMNPRAMNAAPPPFPGMMMNSGYPRGGMPPGGYPPPGPHNGPPIHHHPPMYNMGNHQQGPPIFICGICRMDIHEGEETILCESGCNMWFHRVCTGLTEAAYSLLTTEQLAEWACDRCIREKKIPLVKIKPQQVMFSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BRY8</accession>
    <name>A0A914BRY8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="RefSeq" id="XP_038078939.1">
        <property type="nucleotide sequence ID" value="XM_038223011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BRY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223011.1">
        <property type="protein sequence ID" value="XP_038078939.1"/>
        <property type="gene ID" value="LOC119746203"/>
    </dbReference>
    <dbReference type="GeneID" id="119746203"/>
    <dbReference type="OMA" id="ATHRLKS"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioesterase" evidence="28">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038078939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="262" mass="29297" checksum="2E663EF2822378ED" modified="2023-02-22" version="1">MASHIGLIRCLLRATSTRATHRLKSYDYVSVMSVESHLETRASSGRCFHEADQNHPRSTSSYSHGRFSQNRDFQTTSKVAASARKEWLPETDELYSRLRAQADRDGWVQVRNTTTDPRPSRYFSRVATENGPVMQYAMFLQKDERKLMGVCQFGEEAQGPQGFTQGGASATIHDVITGLLSQEVYAKFTVTASLTVNFKRPTPLRSAVLMEANVDKIEGRKVFLKSCLKSPDGATLYSDCTALYIIIEDKPHAVDIKYSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BSJ6</accession>
    <name>A0A914BSJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Paired amphipathic helix protein Sin3a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Histone deacetylase complex subunit Sin3a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcriptional corepressor Sin3a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11. Interacts with PPHLN1. Found in a complex with YY1, GON4L and HDAC1. Interacts (via PAH2) with FOXK1. Interacts with FOXK2. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF. Interacts with SPHK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038079153.1">
        <property type="nucleotide sequence ID" value="XM_038223225.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079154.1">
        <property type="nucleotide sequence ID" value="XM_038223226.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038079155.1">
        <property type="nucleotide sequence ID" value="XM_038223227.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223225.1">
        <property type="protein sequence ID" value="XP_038079153.1"/>
        <property type="gene ID" value="LOC119746336"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223226.1">
        <property type="protein sequence ID" value="XP_038079154.1"/>
        <property type="gene ID" value="LOC119746336"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038223227.1">
        <property type="protein sequence ID" value="XP_038079155.1"/>
        <property type="gene ID" value="LOC119746336"/>
    </dbReference>
    <dbReference type="GeneID" id="119746336"/>
    <dbReference type="CTD" id="25942"/>
    <dbReference type="OMA" id="ANTWCIF"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000004">
        <property type="entry name" value="Paired amphipathic helix protein Sin3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="9 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="21">
        <location>
            <begin position="625"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="217"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1201"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1210"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1257"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1415" mass="160346" checksum="9D706B2D8CD679A4" modified="2023-02-22" version="1">MKRGNEVQEGPFQQRRATPGQESAFAQQRVLAPANVAGFEQVQEGNMASGLQFHPMQGYPVPAVGQAAGHHGGVHHPHPHPTNPQQVAAVAHQQQVVHQTHAQAQAQVAQVQGHQQQQQQQQQQQQQQQQQQQYQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVINRVSNLFKGHPDLIVGFNTFLPPGYKIEVQASDPTRINVSTPTGHITQHTAGGPLTGPGVPLPQPTPTTQQQQQQQQQQQQHPNKPMTPQKQQQIHTQPQYHAQHPATKPAHHSVSSSHHHANQAATGGHTYSQPPPTNQAHPAPPSAVTASPQHGHAAAAQQQQQQQAQTQPTPQQQQQQPSQPVEFNHAINYVNKIKNRFQGQPEIYKAFLEILHTYQKEQRAVKESGGTYVPTLSEAQVFEQVAKLFKNQEDLLQEFGQFLPDANGAGISGPTNFSFQDMMNRVAVRNDHTGIAKKPGSASNNKNRNNTSGAAGHIKRPGSSAVPIPTKKPKSGAVKDVSLAEAGKHGSLSEFAFFDKVRKALRSQEVYENFLRCLVLYNQEIVSRSELVQLVTPFLGKYPELLKWFKEFLGYKESDRIDSHHAPKERNQGELAMEIDFANCKRCGASYRALPKSYQQPRCSGRTALCNEVINDTWVSFPSWSEDSTFVASRKTLYEEHIYRCEDERYELDIVIEVNAHTIRILEHVAKKLSRMSPEESAKFRLDNHLGGSSETIHRKAIHRIYGDKAQDIIEGLKKNPVVAVPLVLRRLKAKEDEWREAQRNFNKIWREQNEKYYLKSLDHQGINFKQNDTKALRSKSLLNEIEAIFDERQEAMGDNNSPHLSFVYMDKHIVDDSAALIIHHMKRHTGIHKEEKQKIKQLLHHFLPDYMFLERGELSDDEDDQEEETKEAAFALAGMDTAQTDTISPPKDSKKSSLMMTNGPCDNTTWDSDDVYHLFFVNNNWYLFLRLHFILCERLQKMFERAEAIAQAEGGPNRRAAKESTAVALGLKQPLEIEPEEYYPAFLDMVRNLLDGNMESNAFEDQLREMFGIHAYIAFTMDKVVQNIVRQLQHIVSEDTCMGVMEQYLAEMKSGGAGGTHSSATARVSAESAYQRRAEQLLTEENCFKVIYNKSDKKLTIELLDTEEDHSDDPVEVEKWSDYVEKFVNGEDTSAELRDQLAKKPVFLTRNIRRTRQQKIVTDEDSSSSKEKSSDDGKLKEDEKAEDEDEKNSTTAADNKEEGKEEEGSSPSEAEPKEEAAEGGSKEEKPEPTKEKVEKGAEKKEVDPLEGVDMVNNMECKFNLNSYKIVYVVNSEDYMYRRTALKKAKESHWRVTERLAARFNKFLDAWKDDHITRRQEADVENWFMGKVDDLVPCETMVKEVKSANGIRRKFVVEYYETEAPKVSGNIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BU41</accession>
    <name>A0A914BU41_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038079416.1">
        <property type="nucleotide sequence ID" value="XM_038223488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BU41"/>
    <dbReference type="EnsemblMetazoa" id="XM_038223488.1">
        <property type="protein sequence ID" value="XP_038079416.1"/>
        <property type="gene ID" value="LOC119746511"/>
    </dbReference>
    <dbReference type="GeneID" id="119746511"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="1">
        <location>
            <begin position="84"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="351"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038079416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="482" mass="54055" checksum="CBBC07CAFF1CB11F" modified="2023-02-22" version="1">MLSYFSGMNIEGICLNLPRHFGLAVQSLLTDFQSFVQNSKFLQAADAINELKSAFIEDEYCELKIVKALRSELRVNQETLLHHLGEAWSAMTVWTIPHAKEPVTLTNVSQVQLKLVYSENAAVTVNAMSQVGILKSKMQVFGKKLMEHILKPVVSLSNVAPSINAAKKSQSTTVRFKVLSKSSEEPSDPVAVYKSTLAILKALSRPLLSLKTEGKNRDENTTLMALLGEHIWPELSKCIITHCLVHSIPTSSSKLNEYKAVITATERFEASLRKTGQFIAETASLLLTYARDVNVHFANKKCQELIVEARKLMKRELHNTKRVGTMKVDNKNVKDQKQDAKDKCHVSEGIFALPECAVSESIECLVNLAYQTLQEAASNTPQCAIQLFYTVRNMFEIFCDVVPTYHRDSLQKLPLECALHHNNCMYIAHHLLTLGHQYRQSLPPPLCDGTSTFVDLIPVFRKLASECFLAQMKMMLTQLSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YWT8</accession>
    <name>A0A913YWT8_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038044259.1">
        <property type="nucleotide sequence ID" value="XM_038188331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YWT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188331.1">
        <property type="protein sequence ID" value="XP_038044259.1"/>
        <property type="gene ID" value="LOC119718902"/>
    </dbReference>
    <dbReference type="GeneID" id="119718902"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF2">
        <property type="entry name" value="GPS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036861216" evidence="7">
        <location>
            <begin position="23"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="353"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="519"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="809" mass="89127" checksum="82BB0AB01FE178BD" modified="2023-02-22" version="1">MLARGLLVLVSIAAFFSEPARSQQGTDLTILPGARGTAVVEATVSKIDRLTALNTDLRANYRFIRRIAWVETADGTASITYDCDMYHGGIWRVDRSVYDITFGLYNNPSYASIFNDIQQILGINWSRSTWRDCRKPLYSAVAARLYFHSLSPHFIIPGGLNNQASLWRVGYHDQPTGTVENFIRKVRALESEECVQDIDLVFVLDSSGSVGSTDFEQTKNFVSNVVDNFNISAHETRVVYTCHIESTGKSNECGVQTECEVGDILEFLAQVSVNVVKTVDNVLNLPNEIFEKSDDDAAGRILQTFETQLTYIQENLTIDNLSNLAVDVVVLGPDLDTDSGISYASIPRGGFLDDTLQNNEGQLSSVTEPRDDAEAFIGLPGEALKLDDEQGSRINLPVVFAVYQTSKLFQLATPESLSFPDGRQLLVNSRIVSAIVGDRDQIIENLMSPVVASFISLDTSLTGESICVFWDTAASNWSTEGCSQSTVNPGQRPVACDCNHLTNFAILLSYYGDIDNFALDIISKVGCAVSIGALLLTIMACLVHGELRNNPAKKSVINLCVSLLALYAVFLAGIEQAQSPVTCVIMGALIHYFFLTSVCWASAEALNLFYLLVITRRGLMTGYLLKMLLFCWGLPMVIVACTFVVPYLVTGQWELEDEYCFLTPGNALYFCVLLPVGMMLLFNVFIFILLVRRLVCQRIESSVTRRETHLDASIRHGRLMLPISLLLGATWLVGFLAVEDATYFFQWIFAVLNSLLGLAIFLLFIVGKKTGRKGLGKLICVDQIRKMTSTQSSSAIRGSTPHGVDVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YXZ8</accession>
    <name>A0A913YXZ8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038044242.1">
        <property type="nucleotide sequence ID" value="XM_038188314.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038188314.1">
        <property type="protein sequence ID" value="XP_038044242.1"/>
        <property type="gene ID" value="LOC119718885"/>
    </dbReference>
    <dbReference type="GeneID" id="119718885"/>
    <dbReference type="OMA" id="QEHEYIN"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17674">
        <property type="entry name" value="SWIB_BAF60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated regulator of chromatin subfamily D member 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038041">
        <property type="entry name" value="SMARCD1_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="262" mass="30828" checksum="756F4EB700B45307" modified="2023-02-22" version="1">METVWHRTSTTTETDGFQVKRXSSENVKCTLLLLLDHQPPQYKLDPRLARLLGVHTQTRPVIINALWQYIKTHSLQDSHEREYINNDKYFNQIFDCGRMKFSEIPQRLHQLLHAPDPIVIQHTINVDTAEQKKTACYDIDVEVDDTLKEQMKSFLLSTASQQEIATLDNKIHETVETINQLKVQREFMLGFARDPQNFISEWLVSQSMDLKTMTDVVGNPEEERRSDFYFKPWAQEAVRRYFYSKVQQRRAELEQALGIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913YY92</accession>
    <name>A0A913YY92_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="RefSeq" id="XP_038044719.1">
        <property type="nucleotide sequence ID" value="XM_038188791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913YY92"/>
    <dbReference type="EnsemblMetazoa" id="XM_038188791.1">
        <property type="protein sequence ID" value="XP_038044719.1"/>
        <property type="gene ID" value="LOC119719362"/>
    </dbReference>
    <dbReference type="GeneID" id="119719362"/>
    <dbReference type="CTD" id="9836"/>
    <dbReference type="OMA" id="SDCCTLR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000207">
        <property type="entry name" value="Leucine carboxyl methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038044719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="772" mass="84826" checksum="145BC6F4F1C092DB" modified="2023-02-22" version="1">MPRSSKQGNDVAVQGTNDSSIVSKCSTASQGYFNDDFLRLFVSKTSRRAPLINRGYYIRAQVIDDVLKQFLSVHQGKKQIISLGAGFDSAFFRLRASGHLVNTTFYEVDFPDVVRRKATIIKTTAQLRQQLGEDINDAQEYAKGIFLISHDYRLLGLDLTNLPGLQRCLQQTGINCHLPTLLLSECVLTYMEVRSSDALIQWASSSFPNAVFLTYEQIHPSDAFGLVMRKHFEKLNSPLKAIKTYPTTEAQQQRFLSLGWQGASAIDMNTYYNTRLPVKEKLRVESLEPFDEFEEWHLKCSHYAVIAGCNGTCSNMAEFLSEGHQPLTAQCIPELSSIVTFPLSEAQQKPLRRFGHASSLLSADTAIVVGGFGEDGGKHTRLGDVVVVDLKTGSWGMVPASHGTQELGPRMHHSLTAISGGNRWLLFGGRSSPTRPYNSTLILTFDTKQHDTAVRKTDDQMSATSEDGNQVLLPDSTGVSPNCLPSGNNSRAQTNANETDGSGLGLVRLQNRTAKNCQHFVARRGRTAQAENDNPSSNPEKLRYSEKNPSSRENRVCDITGFSYQCSETPNSDGPVPRWRHSAIRANVRGKECVVIYGGRGAEDAVFSDCWAFDVGGLDWQRLEITGDQPPASHSHSTCVWQDTRMVIAGGLGTDMRPLTSVHVIDLETLRCQEIKLTPSLPPRYSHTAHVVDSRLLLVGGVNPLGGGGYTVAVVDLEALTCRLHSIPACVVDRPLMVHGHTSELLTETSLAILGEEATASHLVHTLMTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z0W5</accession>
    <name>A0A913Z0W5_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045468.1">
        <property type="nucleotide sequence ID" value="XM_038189540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z0W5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189540.1">
        <property type="protein sequence ID" value="XP_038045468.1"/>
        <property type="gene ID" value="LOC119720034"/>
    </dbReference>
    <dbReference type="GeneID" id="119720034"/>
    <dbReference type="OMA" id="PELQRKW"/>
    <dbReference type="OrthoDB" id="10046820at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="137" mass="15426" checksum="5B3D5E2809487D46" modified="2023-02-22" version="1">MAARGRYRRISDVDRNRLIDAFEADDADYLQVADTLGIKHSTARSIVGVYLRDGRRNKLPKGGPINQKVDDDMRDALQGYLDDNPLLTLRELNTQLRADLPDKPFVTTSTIARTLDGMLLTLKLAEDVPEQPMSHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1N5</accession>
    <name>A0A913Z1N5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045592.1">
        <property type="nucleotide sequence ID" value="XM_038189664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1N5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189664.1">
        <property type="protein sequence ID" value="XP_038045592.1"/>
        <property type="gene ID" value="LOC119720116"/>
    </dbReference>
    <dbReference type="GeneID" id="119720116"/>
    <dbReference type="OMA" id="SKEDLAX"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="65"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="567" mass="63731" checksum="D3D63ABE68654B19" modified="2023-02-22" version="1">MNHKILKQQLSASSVEDLTNGGESSSSRGSTLTGLSGREAADSGRWTLPRLKTYDAVVFDVLRVMPDDLANQITLMDLPVFKSITPEELSSCAWSGKDKNNLCPNIVAFTRRFNHVSFWVVHEILAGQTLKIRAEILGQFVKIAKKLFELNNYHSLMAVISALHSAPIFRLSKTWNLLHKKERSTCEKLADLMSEDDNRQRLREHMDNVRLPCIPYLGLYLQDLIFIDVAHPSTGGIESERRSIKMNNVLRTIAEFQLSTCEIEPLPYVQNYLKSVRYIDELQKFVEEDNYKLSLQIEPINQQANMSKSRDELDTSDRGSSPGKSTPATPLAAARFVPGHRKCKSLGTTFVSHTAIEPLHLTNSHVGHGPRHLLDDSLLEETSAHGHPSITSSIEGSMNGMSIGSSEGSEISDDHDPWIGDNMTESCEDLVQNLPDVPASAFKIHGYLKRKPVMKIGRKVSVTSWTRYWVGLWGTNIVHYAAKYFTGHDRTDFKIRPCKLFSISDWVVTLPETRGNNIILLTDLAKGNSYKYKAPSYALACQWVRYLDEATKKHRGPKTPANLMSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z1R9</accession>
    <name>A0A913Z1R9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038045627.1">
        <property type="nucleotide sequence ID" value="XM_038189699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z1R9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189699.1">
        <property type="protein sequence ID" value="XP_038045627.1"/>
        <property type="gene ID" value="LOC119720143"/>
    </dbReference>
    <dbReference type="GeneID" id="119720143"/>
    <dbReference type="OrthoDB" id="9988315at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="160" mass="17117" checksum="91C138CC661628DC" modified="2023-02-22" version="1">MDKQPKAAPSAATGSQQPTGNIGNMGTVSGSNNPIIVGASGVSITNYNYPMQGPGAPTPGPQQTPGQEPKVARLDDKTLHEVAERLSAKWTTLAVKELGFSTTQVETIENKFQNNYIRQGLDMLVSWKQAQSSSDKQQVTTLCTALKNIGREDIAKFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z2G3</accession>
    <name>A0A913Z2G3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein OS-9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1. FAM8A1 is stabilized by interaction with SYNV1, which prevents its proteasomal degradation. OS9 and UBE2J1 recruitment to the complex may be mediated by SEL1L. Through this complex, may interact with ERLEC1 and HSPA5. Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro. Interacts with CREB3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038045892.1">
        <property type="nucleotide sequence ID" value="XM_038189964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z2G3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038189964.1">
        <property type="protein sequence ID" value="XP_038045892.1"/>
        <property type="gene ID" value="LOC119720322"/>
    </dbReference>
    <dbReference type="GeneID" id="119720322"/>
    <dbReference type="CTD" id="10956"/>
    <dbReference type="OMA" id="WLKRLYV"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000002">
        <property type="entry name" value="protein OS-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF5">
        <property type="entry name" value="PROTEIN OS-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038045892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="679" mass="76840" checksum="87AB1A8A06E3E34A" modified="2023-02-22" version="1">MAKLTWERCFLVFCCSFSLFCSNIFAFLDLEELKSVHYDIDILSTPVLLGRPVQQEVMHLRSKFGQQYECQLPDMTDYEKDQEEEKLATDMGISELLKPMENAPCLVKTKDWWSYEYCHGQHVKQYHLEDGNVVGDDLYLGYYESEMDWNNKTHKDAKRHRLNRYHSHTYVNGTKCDLTKKPRETEVRFLCAEGQGDSIFRIDEPSSCAYILTIHTSRTCHHPYLRPPPSLKARPVLCYPALEQEQYEKYLEIKQEKQEKDKKNEQHMIAIGTSEGSQSKDSSVADGASTPTQEPSTSQETPARKTPFESALFEDLDQTEVNIDGLEEAMSMGVDPTQLSNLVKSILNSVKDDVKSIDKEVKDKSETGEDSSETKELTREIDDDDDDDDDFLEKLALSDLDMEGMLDDPELQSLMEEDIGELVSRFRRQISQVTSDPVEAAQMHKMLDSIEATLKEIDTVNSLIDETDGDDDDDSDDDDDDENDGDDAGRMLAKTLKNLINEVREKSEENKMADLKKPSTSLSAADAGGKGQVKLKVTKVSLDRSRKAKQDSPKETMVYDNEHRPIEEAIMQQLENAGVNADAGKIEFRIVTYSPNEWPGDEEEDGVTILTEEESNYFKNVVMGLLGGGAETTEQQRQRRLENNYQFTWDSLGTAELGTSSALGTDATTTDAEAEESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z305</accession>
    <name>A0A913Z305_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swi5-dependent recombination DNA repair protein 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Meiosis protein 5 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFR1/MEI5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046196.1">
        <property type="nucleotide sequence ID" value="XM_038190268.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046197.1">
        <property type="nucleotide sequence ID" value="XM_038190269.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046198.1">
        <property type="nucleotide sequence ID" value="XM_038190270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038046199.1">
        <property type="nucleotide sequence ID" value="XM_038190271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z305"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190268.1">
        <property type="protein sequence ID" value="XP_038046196.1"/>
        <property type="gene ID" value="LOC119720557"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190269.1">
        <property type="protein sequence ID" value="XP_038046197.1"/>
        <property type="gene ID" value="LOC119720557"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190270.1">
        <property type="protein sequence ID" value="XP_038046198.1"/>
        <property type="gene ID" value="LOC119720557"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038190271.1">
        <property type="protein sequence ID" value="XP_038046199.1"/>
        <property type="gene ID" value="LOC119720557"/>
    </dbReference>
    <dbReference type="GeneID" id="119720557"/>
    <dbReference type="OMA" id="DFINSCR"/>
    <dbReference type="OrthoDB" id="10051617at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042429">
        <property type="entry name" value="SFR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018468">
        <property type="entry name" value="SFR1/Mei5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28643">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28643:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10376">
        <property type="entry name" value="Mei5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="95" mass="11256" checksum="1CF481B3C5800137" modified="2023-02-22" version="1">MDIAALKLRREELLRQVAADMERLRKLKMVKMYRTKNDLSELQDLIDKWRTACQTALEELHHMTSEPRPPMGKLISDWKVNPELVQFDVETDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z3C0</accession>
    <name>A0A913Z3C0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046207.1">
        <property type="nucleotide sequence ID" value="XM_038190279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z3C0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190279.1">
        <property type="protein sequence ID" value="XP_038046207.1"/>
        <property type="gene ID" value="LOC119720563"/>
    </dbReference>
    <dbReference type="GeneID" id="119720563"/>
    <dbReference type="OMA" id="EYLCIER"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017065">
        <property type="term" value="F:single-strand selective uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19374">
        <property type="entry name" value="UDG-F3_SMUG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000005">
        <property type="entry name" value="Single-strand selective monofunctional uracil DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039134">
        <property type="entry name" value="SMUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235:SF2">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="9">
        <location>
            <begin position="125"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="35042" checksum="F6BE440726295EE8" modified="2023-02-22" version="1">MPRKRAAAPDQTAKPKKVPKNKQQEGADEPSDANLKQDAVNATGDAAAAVASDVATASAAAGNSTGTSAAAVPTSSSGGIADRFLSELVAPFNRDVAGMKFGKPVEYVYNPLEYASEPHEDFIRKYCNSTKEVLFLGMNPGPFGMAQNGVPFGERDSVNDFLGIKGNVGKPPKEHPKRQIVGLSCDRKEVSGSRFWGLWKSLCKTPEAFFRHAFVYNHCSLVFMSETGKNITPPGMLVGARKQIVELCDTFICKMIQLLKVEVVVGIGKFAEERAKKALAAGGVEGVRVVTIMHPSPINPAANKGWDEAVIKQLTKLDLLKYFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z784</accession>
    <name>A0A913Z784_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038046695.1">
        <property type="nucleotide sequence ID" value="XM_038190767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z784"/>
    <dbReference type="EnsemblMetazoa" id="XM_038190767.1">
        <property type="protein sequence ID" value="XP_038046695.1"/>
        <property type="gene ID" value="LOC119720900"/>
    </dbReference>
    <dbReference type="GeneID" id="119720900"/>
    <dbReference type="OMA" id="CDDIWAL"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077361" description="SRCR domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="243"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="347"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="385"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038046695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="486" mass="53171" checksum="F8698518F13E2158" modified="2023-02-22" version="1">MLRVTFYRAILNLLVASLLLSPTGSGDDNLRLKTEILAAILVLLNFNIIVFVSVTQVFYEQTTTPDQTSDIPSEHAIADYTTEPSNSSCSSYEWACHYYGQCIQDYQRCNGYSDCYHGEDEYYCNGNTVAPTVDVNPPSFVIRLVNGSTIYEGRVEVFVNGSWGTACSHSWDMNEAQVICRQLGYGPAINATGYATYGPGVGPIHLVHVYCNGSESSIFDCTSNYSEHCSHSEDAGVECSAPIRLVNGSSSNEGRVEVLYQGEWGTVCDDYWGIHNAGVVCRMLGYHSASNAWSNAHFGQGSGPIMLDNVNCQGYESSIAECNHAGWLSHNCLHNEDAGVTCNSAPVRFVNGSSSYEGQVEVFYQGEWGTVCDDGWDLNNADVVCRMLGYPSASNAWSGAHFGQGSGPIMLDNVNCQGYESSIAECNHAGWFSHNCGHNEDAGVTCNSDSTTEPPYSGCSSYEWQCYYNGQCIQDYQRCNGYTDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z7E2</accession>
    <name>A0A913Z7E2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rho-GDI gamma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038047609.1">
        <property type="nucleotide sequence ID" value="XM_038191681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z7E2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038191681.1">
        <property type="protein sequence ID" value="XP_038047609.1"/>
        <property type="gene ID" value="LOC119721600"/>
    </dbReference>
    <dbReference type="GeneID" id="119721600"/>
    <dbReference type="OMA" id="ICLTIPE"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038047609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="275" mass="31176" checksum="987DCD598BCC1A61" modified="2023-02-22" version="1">MASAAKPPERAKATTFRRPPIWKRFPDLSHKRSCPHDRCVTSTGAMCAQGHAPLTSTAEKSANDKLLLEYLREYLTELKRGDEPEAVPAQRGTEDLTRDYPPPQQMDLQTLQELDADDESLVKYKQTLLGSTADFLDEGGQNVLLKAMVFAPVDHEETVLNLTGDLSQLKHQPIVVKEGTEYRIKLKFRVQRQIVSGLRFVYAVSRKGIRVDNANSMVGSYGPKTEEQIFQTPVDELPAGMISRGVYIVKGKFLDDDKNIYLEWEWSYSVKKDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913Z966</accession>
    <name>A0A913Z966_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048318.1">
        <property type="nucleotide sequence ID" value="XM_038192390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913Z966"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192390.1">
        <property type="protein sequence ID" value="XP_038048318.1"/>
        <property type="gene ID" value="LOC119722338"/>
    </dbReference>
    <dbReference type="GeneID" id="119722338"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="404" mass="43065" checksum="D4AE155FE65E4973" modified="2023-02-22" version="1">MADFMKVAKSKIDASAGELNTISQEIWSHPELNFNEHHAHEVLTDYLEKEGFNVERHFVLDTAFRATFGSDNAGPNICVICEYDALPEIGHACGHNLIAECGVAAGIGIKAALEASGNKYGKVTVLGTPGEEGGGGKKRLIKANAFVGIAVAMMAHPYRYNVPRPIALSMTVLVIKFQGKASHAAAAPWDGNNALDAAVTCYQSISNMRQQMKPACRVHGIFTNGGAAPNIIPEQAELTYYLRAVDENELAMLKKKVEACAEGAAIATECKVEIDASGISYANLITNDGLSIMYEAHAQGMGVEFSRDEALRRGGSTDMGNVSYVVPSIQPKFTPGSGDAAIHTRPFASVAGAPEAQAPTLIQAKALAMTAIELLQPSGQDTLKKIQKEFKETVSKLPMPDMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB22</accession>
    <name>A0A913ZB22_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Diacylglycerol O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048978.1">
        <property type="nucleotide sequence ID" value="XM_038193050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZB22"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193050.1">
        <property type="protein sequence ID" value="XP_038048978.1"/>
        <property type="gene ID" value="LOC119722751"/>
    </dbReference>
    <dbReference type="GeneID" id="119722751"/>
    <dbReference type="OMA" id="DEICRPC"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="10">
        <location>
            <begin position="238"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="11">
        <location>
            <begin position="454"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="81956" checksum="CE4413E2F2421144" modified="2023-02-22" version="1">MENLSPSPPVEPPSPWAERRLSQIACEAGSKKQSPSEAGPRPSRGTIARVDSVDSFHVTLDYAEPTLYARASPANQFAKDSTEHRYQQHRHSATNANAPMANGVKPIKRLKHPADQSLLLPLIGTLVFVFLALATCIPVLVFAFIVVPVAYAVRRLVSCRRCACVGCPNLLSAVDRYWLYETELNQAVNQSLLQLDGILEVTRLRDLLLARLVSAENKRGSKLYSRFTQRVIPAGCGYQWSNDDEFNIDNHIIKVTESFRTKADVVGYISKLSSLALRRDRPLWETHVLQLGQEQPDTLLLFRIHACVSDGVNLNELLHKALADTHTKSPVNVPRKTRFGRRALAFNAIRALIVGPLVVIRQILCGNEDFSLFRERRMTGQKEVTWSDPIPLPPVYRVKLVTRSTMNDVAMSAVTGSLRLYLQESGVENPKNIHSNMAVDFRGSDSPRDIGPLGNRFTLANIKLPTSTEGAIPRLWDTKRRLDELKLSAEHVVLYGMTKAVMTTFPESVAQGILTSFFGESSCTVSNLALGEDILSIGGKQLKMILFWMSPGDEVPISVSILTYAGQMRVAILADRGIVPNPQLIADEFKRQIETLVGLLAHRRIPGEYRRRAMDEDEDEDEDIDPLEEEIRTPSSASSRKIRPLSANCLQRPSSRSSSVMRPLSTSTDANEANGTLEGAIGSNREISDLVVGGRAPEKRADSSCSMECVSFSAEVSHSEGELAFDISPCVERRTSAGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZB43</accession>
    <name>A0A913ZB43_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038048110.1">
        <property type="nucleotide sequence ID" value="XM_038192182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZB43"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192182.1">
        <property type="protein sequence ID" value="XP_038048110.1"/>
        <property type="gene ID" value="LOC119722137"/>
    </dbReference>
    <dbReference type="GeneID" id="119722137"/>
    <dbReference type="OMA" id="FWMMKTT"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF434">
        <property type="entry name" value="ZINC FINGER PROTEIN 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="549" mass="65160" checksum="9D78869619DE7A24" modified="2023-02-22" version="1">MAKENRPVCDQQNSSISPDRENPTSEESQGCSVCDKGFSHQYPVVLLQRSHLGINKRPSKWHIPDKDCLDTEHITYRRWSQTSSKPLACNVCNRHFKHDSFFATHKRIHTDTPFKCYTCDRAFYDIRSLESHDKSHSKENPYVCNICRKAFADGSSLHRHVSTHTLERPFKCDTCGMTFRLRDDLKCHQVSHSNEKPHKCDICDKAFKQRASLSVHKRVHHDNKKMFVCEFCNQAFAYSDALVYHRRAVHTKEKPYVCDFCSKAFINRNQMNRHRRRHTNEKPHVCEACGKAFYTAVEVRHHSYTHTHEEQYDCDIWGQRFELTNYLLKYQSDNLKEKPYKCTTCDRVFERPSYLRKHQYVHATERPHVCEKCGRTFSQSCYLLRHQSIHSGEKPYKCTSCDRAFRRQDYLRKHQIIHGTGTPYKCDICGHSFARKRYLLRHQRVHVEEKPYKCTICDKAFKQRSYLRKHQKFHARARPYKCDICGQSFARTRHLSRHQQVVHLEEKPYKCPNCDKTFKQQGYLHKHQKVHSTARPNHHLSTRGTEKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZBJ6</accession>
    <name>A0A913ZBJ6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038048411.1">
        <property type="nucleotide sequence ID" value="XM_038192483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZBJ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038192483.1">
        <property type="protein sequence ID" value="XP_038048411.1"/>
        <property type="gene ID" value="LOC119722394"/>
    </dbReference>
    <dbReference type="GeneID" id="119722394"/>
    <dbReference type="OMA" id="PRANDYN"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038048411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="384" mass="42641" checksum="91F7AD0AC69C5E54" modified="2023-02-22" version="1">MSEADLNSTMAQNFEDKNLTMASTTEAPSELHPYGVLVFAACAWIIVAVLGITGNTMVILAAILSNHVRTTTNVLVVNLSVADLWTCLALPWTSVARLSDGTWPLASVIPCQIAAFMWHTGLGASVYNLALIALNRLVRITQTMVTYNRIFSPRKMVFIVALSWLIPIFVIVFPLTIGVGALGYDLKFDTCTDDDFHPRANDYNLAQTIGFYPIPMTTVIVSYVIIYVHVRRHFKKQIPKTGNEDMATDAGEPSATTMTSMSTTGTSAAVIEGRDESEGVARKHKISHQQLKITKNLFWVFCAFTLCISPYFISLFFANSEVFALYGATILICNSCVNPIIYGVKHPQFKKVLRPMLRCKWQQIPQPSTTLQAILSMRQRVNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZCW5</accession>
    <name>A0A913ZCW5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038049627.1">
        <property type="nucleotide sequence ID" value="XM_038193699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZCW5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193699.1">
        <property type="protein sequence ID" value="XP_038049627.1"/>
        <property type="gene ID" value="LOC119723150"/>
    </dbReference>
    <dbReference type="GeneID" id="119723150"/>
    <dbReference type="OrthoDB" id="5953486at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF18">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="11">
        <location>
            <begin position="51"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123887" checksum="DACDC844FBFF960A" modified="2023-02-22" version="1">MDITKSSSTRRYSDSIQFLAPVSDFNRSLHLAALLKDGSLREAYATAMTDGQLPTNRARVLILGEPRAGKTSLLNRLMGREFDTREQPTEGIETRMCHVTNVDKQWNESKGAKADDIQQCASVVTVLGEVSSARKATTLGSDTSSKNDSTPHTLPELMKMGLQLVCLLVVVFVFGILKYGYTAFVWCTFGVITFMHNYNFAYRFSTYISLFCILFHAITRRDGLLEASSCQEGVGRFVNQTVWSTMQSMVLDTINTILLGAANGFGCRTGVAVAFSASVHPEEIKATQEAAANSPVVSWDILMVVVVSSAGVLLGIGCYSFCTFNDRWHKYRTATCCGLLAWLLALSLKGDCRTRRYLFLFLNGIMMSMQAAWGTIVGRRASHKYGVSASYVTKKTVGFIFGLYLSCIFGWTMRIPNSSLPSMTFYFLSVLSHPLFDLHNTYKVWREKSTFPVKLIREQMKAVLQRQPILETKLSLWDFAGDTLYHCTHHVFMPDRALYVIVFNLHAAVSDEDGQLQKLLFWLHSVCAHARHPDAVIIIVGTHKASVPEAHRLRFTDELHRRITSHFCHRLVLNPLDDKPLFLVENSQPVDEDFKQLRAEIFRQVESAEYAQETYPIKYLHFYREIQNRRKLAETDCAAYVMTLDQISDLARDTCDVTNEDDLKSMLRFFGEAGELIHKDDDDILRQHVVLDPQFLVDVMKKLVRIPRGSKRSHRFAVNWRDYESSGIINEGLLQHIYGDMLHLVPLLTKLLQAYDLMCPVASVFNPNCSQKSFLVPAMLPPYRGESMEFWKPQSKEEVFYFDFGSFDPSTVYSRLLTRCLTHASLDKFDSTSKPLIFADRCRFNIGTRCIFKLQLERRSSQQMLLSVTVLAFEQKYPIWKLLKFLLNVVKSITARDYSQLCFTLGPRCPYCVHEVNSEKSSEALSQDTCENNEREEAKIHVLKMGGNDQPFPTMSPAVMLCGQKRYELVLSGYKSMDTDCGSCHLPQRVAFTTKTPITKLPPDLFHKVCQLLNDSSSNRNWKALAGELGKDAESVAVLDSQRITNPTECLLREWAMISGHVTVNDLMEVLGRPSLLRMDVIHEIRAQMAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD45</accession>
    <name>A0A913ZD45_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049437.1">
        <property type="nucleotide sequence ID" value="XM_038193509.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038049439.1">
        <property type="nucleotide sequence ID" value="XM_038193511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD45"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193509.1">
        <property type="protein sequence ID" value="XP_038049437.1"/>
        <property type="gene ID" value="LOC119723032"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038193511.1">
        <property type="protein sequence ID" value="XP_038049439.1"/>
        <property type="gene ID" value="LOC119723032"/>
    </dbReference>
    <dbReference type="GeneID" id="119723032"/>
    <dbReference type="OMA" id="VANYCPL"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017065">
        <property type="term" value="F:single-strand selective uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19374">
        <property type="entry name" value="UDG-F3_SMUG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000005">
        <property type="entry name" value="Single-strand selective monofunctional uracil DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039134">
        <property type="entry name" value="SMUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235:SF2">
        <property type="entry name" value="SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="9">
        <location>
            <begin position="116"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="316" mass="34155" checksum="2963BFA178D41F79" modified="2023-02-22" version="1">MPRKRAAAPDQSAKPKKVPKSKQQDGADEPSDASLKQDVVNATGDAAAAAASAAAGNSTAAAAVPTSSGGIADRFLSELVAPFNRDVAGMKFGKPVEYVYNPLEYASEPHEDFIRKYCNSTKEVLFLGMNPGPFGMAQNGVPFGERDSVNDFLGIKGNVGKPPKEHPKRQIVGLSCDRKEVSGSRFWGLWKSLCKTPEAFFRHAFVYNHCSLVFMSETGKNITPPGMLVGARKQIVELCDTFICKMIQLLEVKVVVGIGKFAEERAKKALAAGGVEGVRVVTIMHPSPINPAANKGWDEAVIKQLTQLDLLKYFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZD60</accession>
    <name>A0A913ZD60_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038049454.1">
        <property type="nucleotide sequence ID" value="XM_038193526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZD60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038193526.1">
        <property type="protein sequence ID" value="XP_038049454.1"/>
        <property type="gene ID" value="LOC119723041"/>
    </dbReference>
    <dbReference type="GeneID" id="119723041"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000002">
        <property type="entry name" value="MAP kinase-activating death domain protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="18"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="641"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="742"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038049454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128599" checksum="88841192F2388741" modified="2023-02-22" version="1">MEGFQAGKKYFSPRLLDYILIVGSRHPYSNNNVAQTPEMLRRYPQDDHPDFPLPQDVVFFCQPEGCLTVGQKKLSLRENTSFVFTLTDKDSGRARYGICVNFYRPFKSSDRKMEHQNEKALHNDRENSNRNGTLSVPSDEGQRKRSPRTRRKLKQAKKVRNNSLTSLCILSHHPFISTFRECLFILKRLIDSCNDRTCSRKVGGSKGSLRDCVWGVLTGICSDIPPLVRHDVRQIETWILRFLSAPVPVPGKTRVEIQVLDTQPPMVFALPDHTRFSLADFPLHLPLELLGVDTCLRVLTLIMLENKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMGSAEQLLLAPTPFIIGVPASFFLYKPYFKLPEDVWLIDLDTNKITFCGRYEEVPVLPEPEGSVLKKHFKQALTSMSLSPPPIKDFEQSRGEVEAISRRRETFSDETGFNPFIYGNDVDSVDVATRVAMVKFFNSPNVMAHHNEHTRTLRLHPRPVVAFQVHSFLQSRSVLTTFCERLASTQAVEFFGEYCLNPTNVTFLRIHTGVYDPQLIGDKAKWFLEQLQPINFKVQFDNCTLGIPVNSGTEAWSDSSNPTDESGEESDGGSSSSSSYSSLNDFVTDMMNSDIQGDVLADDEETSGLRSQVDETSIYHPPDTLQIPADMSQSDSAYSFPETDSSSSQDTTSPESSDGEELCIASGWRSKTGQDMEADSDADADSIQYDSDTSAQVTRLNLKHKPAAAGTVSSSNAPDSPSLDADVRRRGSGKDERSSPTFLEKVNALFRSDSSDSSTPPTPTRKKPSLLKNIMDLALETTSSKEPVGSPTSIASTDAHEYSPSVRSDPGPYRGSSAAHANTMGLPLRKKKPTSPFPRDTRRSLVERSSLIKHSSTKKPDKDRKRLSISEDRPNSKNDRSMKTLIDDQLFIKEITRGVLEGNNVGWLNWSRLKKLMQSENMRAQVISQLSPQENTTVLDDYIEDTQVSKAVYKGIVSVLKAVIAGLEYSFYTQPIGGFASAYALLEIAHTHYFGKEPDKGKKAHLHGDGIRSESAYAIEGSVVVTPDEQHGGSMAAIPETHSLNEDNFIAAIESWEKRGSVVSSSSTSTEEGAIRVNSPLVEDNRNDSAYELIDMSEVSVGGSTGAGVHGAVGIAAGVAVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZEN4</accession>
    <name>A0A913ZEN4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050252.1">
        <property type="nucleotide sequence ID" value="XM_038194324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZEN4"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194324.1">
        <property type="protein sequence ID" value="XP_038050252.1"/>
        <property type="gene ID" value="LOC119723594"/>
    </dbReference>
    <dbReference type="GeneID" id="119723594"/>
    <dbReference type="OMA" id="HSDYLMQ"/>
    <dbReference type="OrthoDB" id="5982311at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038927">
        <property type="entry name" value="C6orf163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34645:SF1">
        <property type="entry name" value="GENE 136-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34645">
        <property type="entry name" value="SIMILAR TO HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="325" mass="38323" checksum="287D9314A3FFB96C" modified="2023-02-22" version="1">MSRKPVRKVPDSLELIERILQRTTLTTQKVGHKTVEDVGGKVYYDFLDFTRKERDNAVDNAVRETQEAADRRLKKRLEEARKKAEADKKQALEEARLEAERTAARVADARDQLEAERIAKLTWAFKIEKEDALQKQWEECERIKKKAVEDAIAATTRRLRKEFALEKELAVAKALSLAREKFKKRLEEAIRATRVECERIAAEEAARVAKLHREEVLRLEHIIEDLQRQICDEIEAREMVQNDFKAIQQDYRRFLDYTDGKYHSDYLMRLRKHGMRYDVNWDRRSSEDVDIFPLPTFLHNYTRQGKVRADDPSAKVNRFVAVHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZGQ9</accession>
    <name>A0A913ZGQ9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050973.1">
        <property type="nucleotide sequence ID" value="XM_038195045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050977.1">
        <property type="nucleotide sequence ID" value="XM_038195049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050984.1">
        <property type="nucleotide sequence ID" value="XM_038195056.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038050989.1">
        <property type="nucleotide sequence ID" value="XM_038195061.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195045.1">
        <property type="protein sequence ID" value="XP_038050973.1"/>
        <property type="gene ID" value="LOC119724119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195049.1">
        <property type="protein sequence ID" value="XP_038050977.1"/>
        <property type="gene ID" value="LOC119724119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195056.1">
        <property type="protein sequence ID" value="XP_038050984.1"/>
        <property type="gene ID" value="LOC119724119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195061.1">
        <property type="protein sequence ID" value="XP_038050989.1"/>
        <property type="gene ID" value="LOC119724119"/>
    </dbReference>
    <dbReference type="GeneID" id="119724119"/>
    <dbReference type="OMA" id="SANTECH"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3856"/>
            <end position="3882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4142"/>
            <end position="4192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3858"/>
            <end position="3868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3871"/>
            <end position="3882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4151"/>
            <end position="4178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4179"/>
            <end position="4192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="5221" mass="581953" checksum="0924D30C6CF8BFDD" modified="2023-02-22" version="1">[encoded data, 5221 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZHG7</accession>
    <name>A0A913ZHG7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038050475.1">
        <property type="nucleotide sequence ID" value="XM_038194547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZHG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038194547.1">
        <property type="protein sequence ID" value="XP_038050475.1"/>
        <property type="gene ID" value="LOC119723727"/>
    </dbReference>
    <dbReference type="GeneID" id="119723727"/>
    <dbReference type="OMA" id="SEYLICD"/>
    <dbReference type="OrthoDB" id="421668at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038050475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33900" checksum="C30D09A7D503F752" modified="2023-02-22" version="1">MNRLILASSTSNTHKTYRTGWRAFCSFKHNGFVENSPASPEDVRHFIAWLSLQGLAPSTIATYVAGVGYHHKIRSWPDPTHDFLVTKLLAGCRRDNSGSDTRWPMTVPVLARTVQALTHICNDHYEVTLFRAVMLSAFFGFMRIGEFAAISKTHIQNSLLLSSDVQFQDLGEANASVLISFRHAKNNPTGPPQVVRLVRSADESICPVQALSVFAQIRPKVPGSFFCHFGGEALTQYQFNATLKKVLLFLGLEESPFRAHSFRIGAASTAAALGIPLGEIKEMGRWRSEAAQLYIRPLIQCKLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZJ18</accession>
    <name>A0A913ZJ18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">33 kDa inner dynein arm light chain, axonemal</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038051354.1">
        <property type="nucleotide sequence ID" value="XM_038195426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZJ18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195426.1">
        <property type="protein sequence ID" value="XP_038051354.1"/>
        <property type="gene ID" value="LOC119724395"/>
    </dbReference>
    <dbReference type="GeneID" id="119724395"/>
    <dbReference type="CTD" id="7802"/>
    <dbReference type="OMA" id="QVTIICA"/>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29669" checksum="822379ABBF736EB2" modified="2023-02-22" version="1">MIPPNASLVRYDTPVLVSRNTDKKTPRARALRTSPQPPTNAGPVPNPPPKGGSKLPPVEAQKAQQTDEILNSILPPREWTDNGQLWVQQVSSTPATRLDVVNLQEQLDTRLQQRQARETGICPVRRELYSQCFDELIRQVTIECAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMEKKIVELEQDKRELERQVNELKAKCDAIEKREAERRQVEEKKHTEEIQFLKRTNQQLKTQLEGIIAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZKK9</accession>
    <name>A0A913ZKK9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038051854.1">
        <property type="nucleotide sequence ID" value="XM_038195926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038051855.1">
        <property type="nucleotide sequence ID" value="XM_038195927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZKK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038195926.1">
        <property type="protein sequence ID" value="XP_038051854.1"/>
        <property type="gene ID" value="LOC119724737"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038195927.1">
        <property type="protein sequence ID" value="XP_038051855.1"/>
        <property type="gene ID" value="LOC119724737"/>
    </dbReference>
    <dbReference type="GeneID" id="119724737"/>
    <dbReference type="OMA" id="ARVEWNC"/>
    <dbReference type="OrthoDB" id="10352187at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038051854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="245" mass="26415" checksum="2196FFAAAF4F9667" modified="2023-02-22" version="1">MAGPGESDQSQQATTTTSYPSRLSLVKPIYLTGILQLALALSIGVVGMFASSKNCALSITWIYFFNSIWFIVSSSIGLSPTRRGAVTFGIKQIKRTMKWYRIMCVVGLAMIFSFMTLELIGVLREPETEDGEAWNCMTMHLIILGVGLAALLVTMAGIAASTRLIIIFNRMQRQGVGDSFSAESNTVSGSLGQTNYGMNPDMFILPEYSLDADLPPSYTDVISGKADGLDHPASSDVEGPNTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZN44</accession>
    <name>A0A913ZN44_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038052471.1">
        <property type="nucleotide sequence ID" value="XM_038196543.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038196543.1">
        <property type="protein sequence ID" value="XP_038052471.1"/>
        <property type="gene ID" value="LOC119725182"/>
    </dbReference>
    <dbReference type="GeneID" id="119725182"/>
    <dbReference type="OMA" id="MQCVQTN"/>
    <dbReference type="OrthoDB" id="10038561at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF70">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="50"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15556"/>
            <end position="15581"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="10">
        <location>
            <begin position="7903"/>
            <end position="7947"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="7915"/>
            <end position="7948"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8002"/>
            <end position="8034"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8131"/>
            <end position="8166"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8296"/>
            <end position="8333"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8366"/>
            <end position="8399"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8425"/>
            <end position="8462"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8554"/>
            <end position="8590"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8689"/>
            <end position="8725"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="8816"/>
            <end position="8852"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="9231"/>
            <end position="9266"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="9521"/>
            <end position="9558"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="9866"/>
            <end position="10061"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="10502"/>
            <end position="10695"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="11143"/>
            <end position="11318"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="12980"/>
            <end position="13013"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="13738"/>
            <end position="13927"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="11">
        <location>
            <begin position="15010"/>
            <end position="15206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2418"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3666"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4382"/>
            <end position="4429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4443"/>
            <end position="4462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4481"/>
            <end position="4504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4800"/>
            <end position="4830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="6870"/>
            <end position="6890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="7298"/>
            <end position="7341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12828"/>
            <end position="12890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15762"/>
            <end position="15978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4390"/>
            <end position="4401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="4409"/>
            <end position="4424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="4451"/>
            <end position="4462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="4807"/>
            <end position="4816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="7306"/>
            <end position="7333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="12844"/>
            <end position="12890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15836"/>
            <end position="15855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15864"/>
            <end position="15876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15924"/>
            <end position="15945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15946"/>
            <end position="15955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15961"/>
            <end position="15978"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="7905"/>
            <end position="7914"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="7918"/>
            <end position="7930"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="7938"/>
            <end position="7947"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8006"/>
            <end position="8016"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8024"/>
            <end position="8033"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8135"/>
            <end position="8145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8323"/>
            <end position="8332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8389"/>
            <end position="8398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8452"/>
            <end position="8461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8580"/>
            <end position="8589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8715"/>
            <end position="8724"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="8842"/>
            <end position="8851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="9256"/>
            <end position="9265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="9548"/>
            <end position="9557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="13003"/>
            <end position="13012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="15978" mass="1703186" checksum="9F00B09EABBC5AD0" modified="2023-02-22" version="1">[encoded data, 15978 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZNH7</accession>
    <name>A0A913ZNH7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038052929.1">
        <property type="nucleotide sequence ID" value="XM_038197001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZNH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038197001.1">
        <property type="protein sequence ID" value="XP_038052929.1"/>
        <property type="gene ID" value="LOC119725556"/>
    </dbReference>
    <dbReference type="GeneID" id="119725556"/>
    <dbReference type="CTD" id="29099"/>
    <dbReference type="OMA" id="SHHVLFY"/>
    <dbReference type="OrthoDB" id="64318at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037360">
        <property type="entry name" value="COMMD9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048676">
        <property type="entry name" value="COMMD9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15663">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15663:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20923">
        <property type="entry name" value="COMMD9_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="134"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038052929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="210" mass="23396" checksum="023E541AFC9E7F5B" modified="2023-02-22" version="1">MRICSCAPKLVKMTEVVDYDSLNLLLKASSKDLVVRLCDQAFLYRDLIHPPAEVVHKIAEGLTANDGEASKLLRSLGNLIRNVLYIGCTDATSVQAVFPGDFHKNLKDLLTSIFTKKLTTWRNRSVNSQISLPRLVDFDWRVDIKTSSDTLARMSVPTCVLQLKVQENATRVDDAPETSTMNVELSKETLDTMLDGLGKIRDQLSSVAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZSB1</accession>
    <name>A0A913ZSB1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038054653.1">
        <property type="nucleotide sequence ID" value="XM_038198725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZSB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038198725.1">
        <property type="protein sequence ID" value="XP_038054653.1"/>
        <property type="gene ID" value="LOC119726872"/>
    </dbReference>
    <dbReference type="GeneID" id="119726872"/>
    <dbReference type="OMA" id="ESCELAH"/>
    <dbReference type="OrthoDB" id="6133371at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038054653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="388" mass="44133" checksum="BA24F147B46FDACA" modified="2023-02-22" version="1">MASSVTAQSVLEKISVDHLECSICTNRFRQPKLLDCLHSFCLQCLQKLRQSQDPSGTKLTCPLCRRETMLKGSGVADLPNNFAFSALVEEVTMQEKLLEGQGSEIKCQNCKEENQAISRCMDCDHFLCQECQKAHERMTVINSHKICTLAQLQSGEIVYKSKIREEVPKCGKHPDQNLNVYCNTCEQVICLMCTVLYHEKPNHSCVGLPEAFEKSKKKVEKLVAKVGQSKTELNTTIEKTCISRKKLDTMFANTKKKISTKADQEVAKIRQEEQKLLKETDRIYQERITTFKAAQATNSKEVTQTEHKLEEVKQLMNQASCYEILELQQKLLHNLSELTGKQPEQVPDKLTFMDFEEGERSLGRLTLEEEPKVKGPSHRTKPNSEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZUE4</accession>
    <name>A0A913ZUE4_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038055197.1">
        <property type="nucleotide sequence ID" value="XM_038199269.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199269.1">
        <property type="protein sequence ID" value="XP_038055197.1"/>
        <property type="gene ID" value="LOC119727404"/>
    </dbReference>
    <dbReference type="GeneID" id="119727404"/>
    <dbReference type="OMA" id="HQKKIDP"/>
    <dbReference type="OrthoDB" id="5800688at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20097">
        <property type="entry name" value="MBT_dSfmbt-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20098">
        <property type="entry name" value="MBT_dSfmbt-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20100">
        <property type="entry name" value="MBT_dSfmbt-like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF104">
        <property type="entry name" value="POLYCOMB PROTEIN SFMBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="MBT" evidence="4">
        <location>
            <begin position="258"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="4">
        <location>
            <begin position="371"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="4">
        <location>
            <begin position="474"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="4">
        <location>
            <begin position="588"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1789"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1380"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1653"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1397"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1657"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1692"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1714"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1757"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1860" mass="204145" checksum="0529625C4F7E7649" modified="2023-02-22" version="1">MELISSAMEEGWGSSSTQEKSHLSRQSSLVDEGMKGRADPLLSQEPASVLPSYASLMDTDVGHDFSEDKLMKSGNLYSLYLLNSDSGSRQLKANEGLTDTSSVTSKDKKDNNGDTDEEIDVETDGVKDPSPEKVVENGHYDALFEGMPFTELKGKEVGPCSYCNLWRTIRFMSYCGRFPFCSVYCTKKFAVYKRERGELSEKTPEDIKAINKLKVPTLFENQKARPLFPSSQIMEVDNKRPRVCTNGSVDGPESLKQFDWPLYLEGLNAEAAPVKCFHHAPLAKEWKANLIGALVEVQNREPEDTKDCFWIARIIKVAGYKAKLRFEGYGMDSSHDFWIHLCKAECYPVNGAEKVGKQLKPPKEVLDKLGCNWREHTTRVAHSGSPTFSIDKEKLDESLTSPFKKDTQLEVVYKRQVSSTCVATIKKVVADRIYVQYENCKDTSKDFWFHQTSPLIHPVGWSQRVHHPLVATAAYKAEALDKGRKKKGGPRDAPWEVFQLPKPIPEEQNFCVGMKLEAIDPLKLGSVSVATVVQTLGDGYLMIAIDGCLHDVASWFCYHATSSSLLPIGFCEYHQIELVPPRGYEGKFDWDDYLKATNSIAAPVELFHQKKIDPPFRVGQKVEAVDLIESGFICAATILKIAGPLLRVHFDGWDRSYDQWLNCQSPDIYPVGWCEMVGYPLQPPRVHDPANHILPTPVLKNGKKHKSTSSPPSHEKRKRSFSGSAGYFDKSESVSSMVDAIYSFSDTEDHVPPKPPKVTKKEKTDKQSKKDRKSASSKEKKSKSKSHSKLKHKEYAKNNVQMLLSQSAPNLGSLKTASSKKLKDALTPTTSSGNFDGTPFLESPLSMRLLPDSPLSSSVDSFTSLSNGGGPSTSLTPVTGLPLDPLQMSPLTSVSDSSFQSVLAKASCSSLMSHSERTLTSEDKMRNGKVSPSCPSASSSQLQRESAEFTKKIPFLSSKHSGSKHKSKKSKKSKKTRDKDKSKKEKKCKKKDKEKKRKYQDREKNPSEKKNGSEGKISKLAALLSLPGQINFPDNKPLINGFLNASNEVTPPVPPAPPKPPKIELPDHDPFAFETEEEIQERLSLKKKVAPPVISSTEQSVAALLNSVKSAVPIKKVATAKKLHAKKAKQSHMSVPNTFQPTPDIDVISQESSDTSLPSGNFALAQSTKQKDFVQLPSHPSPPNMLAGSPVSAFPKHQQSPVPSPMNVPKSMADPPTVQAPQLMELRKPPINIHPRDAQTLLRTLQFQDPNLYRRFLNLNASSAPFIPSRSSLPPSQDRDPQNTVPIVHTVPAPTIRRNPQSLPRLINPQGKPPVQNPEDMIMLQHAVPLNRLPSGNLMSKKQKVEQLSRLQLQDMISAMPRDCFVENLPLKKMGEHIGQTVPQSRPNVPSAKRRSPTVSVTTTAKSRTSPIEQLILSQGPKTNINPPTLVSPSTIQSPCVASSPHMMSSPCSASSPQTMHSPQTVFAPSPHAMTSPQFLPRGATRTLPSPQAQTQGVPPPGYPLHVANSHASPVMSGIVRPKQDPHLNRTIHKQPSLTGAPPGTHSIMHRLPPLETILKSLNSAANPISPTLGSDAIMNNPHGIQPASLRPNRPRLVRPHSFPDASVFPSVSVAVQSASSSFPSPTSPSFPYQSVNFLTSVPKSHSDLSTAAMVNQSSKTKTQTSSMVNFPTLNRSTSTHSALHKPLMPNLPTSPTNSQASCSANFKLSGFQPNPGSSSSASSKSGGLSVPSSPSSPRSNSSLSKGNPPTPRSKATTPSTPTESGPGCILEEFTLQRMVRPEIGIMNPWNWGICEVIQFLIDAGERGCVETFSKQNIDGRKFMSLTKDQIAKLTGMKVAPSLKIYQQIVRLRSLFPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVI3</accession>
    <name>A0A913ZVI3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038055504.1">
        <property type="nucleotide sequence ID" value="XM_038199576.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038199576.1">
        <property type="protein sequence ID" value="XP_038055504.1"/>
        <property type="gene ID" value="LOC119727617"/>
    </dbReference>
    <dbReference type="GeneID" id="119727617"/>
    <dbReference type="OMA" id="VIMDWWY"/>
    <dbReference type="OrthoDB" id="10021393at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032770">
        <property type="entry name" value="DUF4537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46785:SF1">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15057">
        <property type="entry name" value="DUF4537"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="533"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1935" mass="219572" checksum="27CC527281F76509" modified="2023-02-22" version="1">MYEIDSGNVRSSTEMENPKFDLGPRHKNNNNNQPPDISKEDIASVIKLKPPAKKTWEPDVKALISTKKWLSTYGLKKNRLTVDQILATVGFKHSDEYDRALKKPICSRYGEGLFTRYPARNGKVYNVNVKVGREKIKQLENSLLAAINLYKRRIEWLTSEARRLFGVIEDHCITIVLDVKTSSPIQFDHCRNAIIRVLQEQVSQIAKFNLIRAAEDMVMFQPNAVPVSRDSLQNAIDWLHNLDSVAATTKTSGCEGIRKAFEDKNIEAVYLFSEGSSASTNMELMLQKVRDAPLPVHVVAFNNTDSITIKYLKDVSRLTGGRFHAFAFNKLDSDVSGTSGFSLDNKILMGGVPPGAGAREDVVAMFAELEEARHALSDVQVLLENTVPDGKPESARLAIQNGEVPATGERSEQYMGSKEWLYRHGLKSRKLDLYDALGLCSFKHCDGIVDVKRPPDDEYTDAASRNKLVNAKYCDKFCHVTWKDGSLKHVHVTADIHRNYERKTLVALEDFQRRVDWLQQGSRELFGTIIEDEVYILIDTSNSMENHLGLVKEKLYKLMQEQLRHKSRFNLVKFGSRSMSWRDRMVEVNESSLQSAWQWVRNLSISGSTNTLAALKTALGDVNTQAVYLLTDGRPDHPSKTILAQVQLQKAIPIHTISFNCNDREANDFLALLAADSGGRYHYYSDELLGISPDISGPQPYESEDVRLLKEEMKKGKDDLKKLADLRAQCALLDWGNSRSDELGCGRDHGIRKRPSSATGLRSASQILSRDSASPAPPHNSRPASAHGYHTTIRRPMSSLSMSSTTHEKCKPSRSRTATYPPRPNSAISRKNKPNVTYHNKTSWLRLRGSLDGWVVPETRGMLLKQQDRVSTALQGLANAQQKPKALKKKKVVDPLKMSSKRWLQKHGLKARKLTIYDALGKAAVKQRSKYVPILDKHIISQVFNEILPLAHVTDNKQEISLVNPYGINLKAYDEKLERAISGFNKRLDRIVWEALTPEEQDQFDCEGPISFLDNRKDCLDALDRLGWPLPEKDILLLEDEIEMGNRYLRHSHAIQRALKQKLNGSQSGGSTARSLREETPRRKEGDRRRPRKTSEDAMDDASEAGTRRRKASEDTSERSYHSDDEDEEHDDRRSRSEDSSDSSDEELKNVRDSDDSSNDDEIRKPRVVVKGGRDTKTKPKKKPPGRTATTKTIKQTYPARLPIRSKVIARSSVNGLYYPGIVSGITDARHVEIRFAADEDKEVIPSRFVIETQGARPSPILRTGDFVMVCCLSAGSEVWMPGILQFGPRDESRQAKHYTVITYDHRSMDVPRKSLIKIAQARYNFMVRYIWSLRKSSRVPNAVWLVSGDNEDNEQVIQDLEDESGMHLSLLQRTPSVEQEAQTEQPQTASEEVQADDTAPEDIRETLSELQQQMRQHHEEHIQTQQGLQEELKESFKQQKLLDEHQNQLLQKHDDLLHKHSELQREYDATARQHQKLQKRHSKLKGKHSLLKEEHGVLESTHRELDDRLHDMSNKHGSLENDYTSLKEKQDDLEKELQEKLKMQEEWEEERSRLQTGGQEGDIAQDGEDIEDENNDNTKEEEEHEKDKVVDEAMDEEADVATAIAAVNGDDGVDEADYKRQIDIRDEVLAQSPEDGWFYRGTVNSKSEDSEFYVEDSNGTIQKVSTKYILTDKEDGNRMIQQGDTVIALHPGHPFRYGPATVIKLLQDLWCQVEFYDEEIADVPREEMYYVTPECHDEVKEAILVGEDRWVGHPAVARRDEDGVYYLATVTERINRGRYFVVEWPDDATSQQHCKHIFGAFSRRQRFALGDYVLAMASAVKMTYLPSKITATDGDKLVVEFCDGTSSNDVDAIQCFWLSEGYYENSRIFHMRQNVEVPAIQPAPLQPTPPRSRPASASSISSRSSLGSRFKRSGSPTSSTSSRSKSVVSAADEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZVW0</accession>
    <name>A0A913ZVW0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055649.1">
        <property type="nucleotide sequence ID" value="XM_038199721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZVW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199721.1">
        <property type="protein sequence ID" value="XP_038055649.1"/>
        <property type="gene ID" value="LOC119727705"/>
    </dbReference>
    <dbReference type="GeneID" id="119727705"/>
    <dbReference type="OrthoDB" id="5964498at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF421">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="11"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="292" mass="33092" checksum="B7039E50C255E7FB" modified="2023-02-22" version="1">MVIAIVPNLLLNPLMLVTLRRVTSIQPTTKIFMASLTLCDLCRSLWGILILTSLLADTWLLGSFLCAANQVMLFFFTALSVSTLLLLTVDRYIAVSHPLRYPSIMTVFKSKIIVCSTWATIIVSSILINGINPFYTIQVIGHNKRLCVAETYDWRVYLILVLVVLELLTIFILYAHIALIARNQARRIAAENQAGNGQGGQRINTRSTTTIIIITGTVIITWIPTLIRLAIASQNQWEPHVNYLAYISTEAMLLSNGWMNVIIYYLRNKDLRQALLGLLTDWRQRLSQRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZX11</accession>
    <name>A0A913ZX11_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055586.1">
        <property type="nucleotide sequence ID" value="XM_038199658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZX11"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199658.1">
        <property type="protein sequence ID" value="XP_038055586.1"/>
        <property type="gene ID" value="LOC119727666"/>
    </dbReference>
    <dbReference type="GeneID" id="119727666"/>
    <dbReference type="CTD" id="3093"/>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22130" checksum="4A7599AEB3F0C2BC" modified="2023-02-22" version="1">MATIAASRIKRELKEVKADAELIKDDVSVELMDNSYLALTGEIPGPKDTPYEGGTFHLKIIIPETYPFNPPQVSFTTKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSVQALLSLPEPDDPQDAVVAQQYKENQDAYRRTARHWACAYAGAKSSSRELDEKVERITEMGFNESDARDALSSTDWDVGRAVEKLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZXY6</accession>
    <name>A0A913ZXY6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038055916.1">
        <property type="nucleotide sequence ID" value="XM_038199988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZXY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038199988.1">
        <property type="protein sequence ID" value="XP_038055916.1"/>
        <property type="gene ID" value="LOC119727909"/>
    </dbReference>
    <dbReference type="GeneID" id="119727909"/>
    <dbReference type="OMA" id="AWTKPEC"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038055916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="398" mass="44227" checksum="7E9EA5EED3630DED" modified="2023-02-22" version="1">MRKAQSTDPMATQVSDVGLAQNAVKASNTFASYIFRVLTEGGGSNNNIFFSPLSISTALAMTFMGARGETASQMSQVLHFNVLEESVLHQSFADLSALIFRAAIPCTLVAANRLFGPKGLDVLATFVDDSKKYYGAGMEILDFIGDGEGSRQHINSWVEKQTANRIKDLLAAGSINAMTRLVLVNTIYFKGDWADKFRYQDTNFNGTFRTVGGYEKITMMRKTDKFNYARDDSMSSSILELPYLKNEVSMFIVLPDQVDGLADVQKKLSQEKIDSWVTEARMRDSPTVMVYLPRFNLEQDFVLNDVLRKMGMNDPFDVAKADFSGMTGDKDVFISKVIHKAFLKVNEEGSEAAAATSWLVIQSSDFGPLKFMADHPFLLFIYDNKSGAVLFMGQLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZY74</accession>
    <name>A0A913ZY74_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Guanylate cyclase</fullName>
            <ecNumber evidence="2 13">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 13"/>
    <dbReference type="RefSeq" id="XP_038056265.1">
        <property type="nucleotide sequence ID" value="XM_038200337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZY74"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200337.1">
        <property type="protein sequence ID" value="XP_038056265.1"/>
        <property type="gene ID" value="LOC119728204"/>
    </dbReference>
    <dbReference type="GeneID" id="119728204"/>
    <dbReference type="OMA" id="QINWTAK"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000019">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF507">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="137"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="500"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="699"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="749" mass="82735" checksum="DCFE622BA9BF5971" modified="2023-02-22" version="1">MCGPWVSPRGDIFTHTESQVDSLNHTDWSIVVALVPDGVTSIIAHIRIGNLQAALHHTLTVKPRSVCGNTNCETEEGEDCSTCPADCNACPMSQGAIAAIACTCVFIMAVFCGLSGYFYWRQEKMLWDESWIVNYDDIKPDTGMRGFTGSVISVRTDNEASSIGGLAAAAHSKQLFTQTGILNGQTIAIKIINKMSFALDKCIRKEVKQVRDIHHVNLCKFMGGCIEVPHVAIATEYCPKGSLTDVLLNDDVPLNWSFRFSFCSDIARGMNHLHSNKIYHGRLKSSNCVVDDRWVVKISDYGLRDYRKIEGVQPGENETYAALVARVYLPPEILEFPNSAITPAVDVYSFAVILVEIATRNEPCESQDLDKVDGRWRPSLPDLNSSDVMPDDERCPCPEDYKKLIERCWQTNPTLRPAFSQIKSTLHSINPNKLSPVDMMMQLMEKYSKHLEALVAERTQDLELEKQKTDRLLYSMLPKPVADNLRQGITSKAEAFESCTIFFSDIVGFTSLSSGSSPYEVVALLNKLYVTFDSIIDAYDVYKVETIGDAYMVVSGIPKRNGLLHAGEVASMALDLVQVCETFIIPHRQNVKLRIRAGIHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIQASEACVKILEVLGGYDTVVRGEMPVKGKGIMITYWVEGKHDQPTTDSTQTLLTATNVVLNGEPDKPAGSPREQLSVSDGEDSTNRKVSLPGSMEDRDVNEKSCLINESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A913ZZS8</accession>
    <name>A0A913ZZS8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via cytoplasmic region) with ILK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038056835.1">
        <property type="nucleotide sequence ID" value="XM_038200907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A913ZZS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038200907.1">
        <property type="protein sequence ID" value="XP_038056835.1"/>
        <property type="gene ID" value="LOC119728607"/>
    </dbReference>
    <dbReference type="GeneID" id="119728607"/>
    <dbReference type="CTD" id="55246"/>
    <dbReference type="OMA" id="YHDEKAV"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038056835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="205" mass="23928" checksum="0336016CFA5CBEC3" modified="2023-02-22" version="1">MVFYFKSEGYVIYVGIDKYENEELIKYGFPEDIWFHVDKHSSAHVYLRLPKGENIHAIPATVLEDCAQLVKANSITGNKINNINVVYTPWSNLKKTGDMDVGQVGFHKQREVLSVKVEKRSNEIVNRLNKTKEERMPDLQAEREERDRVEREAAKKVTREKKEKEKEEARQREKDAEIRNYSSLMTASNMRSNAEVHSDDSDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A0G3</accession>
    <name>A0A914A0G3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057080.1">
        <property type="nucleotide sequence ID" value="XM_038201152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A0G3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201152.1">
        <property type="protein sequence ID" value="XP_038057080.1"/>
        <property type="gene ID" value="LOC119728769"/>
    </dbReference>
    <dbReference type="GeneID" id="119728769"/>
    <dbReference type="OMA" id="NANAFCC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037746692" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17157" checksum="E05E0224A885335D" modified="2023-02-22" version="1">MKTFVVFLGICSLSFFEIGALELPTCPTPSDSGVSVCQTSAKYPSACLDDAREACREDGHHLCSLDELKAAFDSGVRSTNWNLLDVRDRDARIHVCQVGSGKRYDGDECFVKVGPYATWHIPNTPRPYTNANAFCCKNDPATFTYHDVKITIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A200</accession>
    <name>A0A914A200_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histamine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038057873.1">
        <property type="nucleotide sequence ID" value="XM_038201945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A200"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201945.1">
        <property type="protein sequence ID" value="XP_038057873.1"/>
        <property type="gene ID" value="LOC119729319"/>
    </dbReference>
    <dbReference type="GeneID" id="119729319"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34275" checksum="32DEE468722D7800" modified="2023-02-22" version="1">MSENAVPSQTLTEYCNSLDYYNVNFDVYNRVSQRINRFSDWIDKSLPKLADSMEISLPATGTLNVLSVGAGNGTIDSRILPHLRDKVHPNVRAIFLEPDLHTFQQCQDLVGKESPRLQGIEFDWRQQTFQEYRSTAKEEDKFHFICCFNSIYYTGDMGSSLRYLYDKLHSGGILLITLVDGKSGGGQFWQFLNTSLGQEKDFFTSFDLEEACRKQNIMISEVQPIGIYVNVSCCFDPPQELTEDGRYLLDTITRSVNFAQTAAAELRKDVLRFLRSDTCSSITADGQVILDGSNSAYIIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A2G0</accession>
    <name>A0A914A2G0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038057556.1">
        <property type="nucleotide sequence ID" value="XM_038201628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A2G0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038201628.1">
        <property type="protein sequence ID" value="XP_038057556.1"/>
        <property type="gene ID" value="LOC119729112"/>
    </dbReference>
    <dbReference type="GeneID" id="119729112"/>
    <dbReference type="OMA" id="QANCTHR"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037424837" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038057556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29344" checksum="CDA3085ADCF63458" modified="2023-02-22" version="1">MAFMSEFFAIVVAVLSMRALSESDFCPSRSPVKSSCPPEWQLWGSACYRLTSSTYNWDDAKTACQDVGGKMAAPRSLEELNFMAELARKVDSQYRAWIACNDKEVEGAWECDGQEGGEPFLVWADGQPNSWGGNQDCAKLAARFNDTMDDARCESPWRAFCVRHAACTHLPTQPRRYCLSTDTHGRILNSTCLLDHNIREFITEGLVACGSACANESGCRSFNIKKTKEGKKVCQLNNSTSSEVKDKFQKTDYFCMYSEVCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4G1</accession>
    <name>A0A914A4G1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058737.1">
        <property type="nucleotide sequence ID" value="XM_038202809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A4G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038202809.1">
        <property type="protein sequence ID" value="XP_038058737.1"/>
        <property type="gene ID" value="LOC119730019"/>
    </dbReference>
    <dbReference type="GeneID" id="119730019"/>
    <dbReference type="OMA" id="FIVEMAM"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="646" mass="72584" checksum="9FEED63613428314" modified="2023-02-22" version="1">MATALKNIRPHLECIICADKYKQPKVLDCMHSFCQKCLEKYYTSRYAGQPKIPCPVCQRETVLPETHIQGLKTNFHLMGIVEEVSLQEKVACSENTKVICEICDEGNEAMHRCLDCAQKICPNCRKTHLRFAATSNHTVATLEDIRQGKVTVKKKPEEDEYKCHKHKGEGKRFYCETCEELICRDCTVVDHCKPEHHYIDSGEASLKYKQSLKDTFPDFTTGIKRLQQSLTTSSQAKQKFTQRVTKTVKAVKDKADKMRAEITTQETKMIEEIKQLQQDRNRTYDEHQSTLTMMLENKNHLLRTLQDIINTASDSDFLSLYPIFSKDWKSLKSQIPLQIDPKLSYLSFTPGQRISAINLGKLEVEAVKWEMCREFGTEGSGPGEFNGAWDVTATQPGEIAVADLMNNRVVICSNEGQHKGTIPVQSDPQAVAAIHNPEQRLLVLEAGSKYVNVFNMKDNTLVTQFPTMLKHQVEKTEMNLQSLAVKNSTCTIVMGDIKRMVWTEHKPTDGEILHTIPVQTPPHYLAVDDDTDRVVVSGGKTKKVDVGNSKGRTICTIYPTINGEPVQYCSGVCCDSSGIYLAVRQGVSGTGHIHHYDQDGGFLDCLAQGLFAPCGITFTSKGQLAVADDNSIKMYTRCDVIQHDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A4S4</accession>
    <name>A0A914A4S4_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038058549.1">
        <property type="nucleotide sequence ID" value="XM_038202621.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038202621.1">
        <property type="protein sequence ID" value="XP_038058549.1"/>
        <property type="gene ID" value="LOC119729826"/>
    </dbReference>
    <dbReference type="GeneID" id="119729826"/>
    <dbReference type="OMA" id="NTCTEIC"/>
    <dbReference type="OrthoDB" id="10068969at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038058549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1482" mass="166796" checksum="00F554E53B706FFA" modified="2023-02-22" version="1">MIEVLDSDDANSASSQRTRASHKTSRSSLKSNMSSAAILARAKAKSLKAKVEFTQKEAGLRRQEQDVANALLLLSAEKEYAMAEAEAEFLESVALKEGSASIQEDLQLPVVDSAVRTSDYISHHFKEPETELPEKEKPAIKIEEKSPPEVQPVIRDKKDDAETKPALPSQSIPKDGKLPEPPSPPIKESLNSISNMLVKKELVKSGIRKFKGSAGNYRAWKCSFQQATKDLELKPYEELNLVLGSLEGETEMFVQRIYSIHIDRPEEGLKRTWEYLEQKHGSPEAVERDLTGRLEQFQKISPKGSTKMEEFGYLLLEVQYLKESEKFPGLLALDSSRGLQPLVQKLPEWLQNKWREKGSEYKKKHAVLFPPFEEFVKFIQHHARVQSDPSFQFTDAVKSAAERSSSRPSFTVRKTGVEEGSAAKETSRCPVHNTAHKLQDCRVFRQKSIDEKISFVKENRLCFRCLRANHIIKNCKTPVRCDICGKSHVTVMHRPAPSQEVPPASNQTPPTMKYDNRPQIIVTPKCTRVCGNGKEGRSCAKICLAKAYLEEKPDHVITTYVIIDDQSDGSLINENLLERLGVEQNKSTYAVKTVNGLQEVHGRKLSGLVIESMDGTVSAPTPTLFECNNIPGDVAEIPTPEVAAAFDHLKPIAPMIPPLNKDAEIAVLLGRDAPQFHKVREVINGKDDQPWAHRLDLGWVVVGEVCLNGAHIRTDISYLQQDVISTYFTQVLRNGRHSAQFQPCDKAVKVFHTRPKAAELGEEVFISTSADERLGPSSDDREFMELIAGKMKKDQDGNWCAPLPLRKNRRRLPNNKTQAVSRMKALASSLAKDEKKRQHYIEFMRKILEKGLAKQVLDEAISASEEVWYLPHFGVYHPQKPDKLRVVFDSSAIFSGISLNDVLLSGPDLMNQLLGVLIRFREEPVAVTADIEQMFYAFRVREDHTRFLRFLWYEDNNPNAAIVTYCMTVHVFGNKPSPAVAISGLRKTAEEGEAEFGTDVRELIERNFYMDDLLKSFPTKEEAVDVLKRTKDLLSTANIRLHKFASSDAGVLAAFEPSELALNLAEADLSNKDESTIRRTLGVSWDLKADSFTFQIAEPNANACTKRTVLSEVNGVFDPIGLAAPVIIKGKMLLREMTQDGGGWDDPLPKDLLQDWVMWRKSLIALTDVRVPRSFAPFSTTEVVRRELHTFGDSSNKAIGAVCYLRTVGSNDEVHVQLVMGKAKLAPKAAVTIPRLELCASVLATEMEDYVTQELQIKVDESKFYTDSKVVLGYITNRKRRFRTYVCNRVNRLLKTSEPEQWAYVPSERNPADLASRSILAAELSGSMWIAGPEFLRLKDLPSSHKQREIEILQDDPEVSPEKISCNKIVLTDASFGSERFTRFSSWDSAMRATTNLIHIANSFKAEFDCKGWHVCEKAKSIRERLKAETVIIKSVQSEAFATELAEFRTTGYSESEADCRKLNCQREQHTQLYYQKTTTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6F2</accession>
    <name>A0A914A6F2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059442.1">
        <property type="nucleotide sequence ID" value="XM_038203514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6F2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203514.1">
        <property type="protein sequence ID" value="XP_038059442.1"/>
        <property type="gene ID" value="LOC119730541"/>
    </dbReference>
    <dbReference type="GeneID" id="119730541"/>
    <dbReference type="CTD" id="5902"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000136">
        <property type="entry name" value="Ran-specific GTPase-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF94">
        <property type="entry name" value="RAN BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="258" mass="29518" checksum="C50D762F9123913A" modified="2023-02-22" version="1">MADVKTEEAPHSPEIHFEPIVRLESVETKTLEEDEEEIFKMRSKLFRYDTSSDPPEWKERGVGDVKILKHKGAQPRARILMRRDKTLKICANHFITPFMKLQPNCGSERAWVWSTPADFADEEAKGETLAIRFANVENAQKFKDKFEECQRMISEQEKKDNEKPESTDKPAEENGEKPAEENEEKPPAETSEEKSADEIAEKLGEMTVKEGEPAEGGDRETTKEAEDNKKTEDKTEVQQDAKDSKVKSENEQSDAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6U2</accession>
    <name>A0A914A6U2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038059518.1">
        <property type="nucleotide sequence ID" value="XM_038203590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6U2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203590.1">
        <property type="protein sequence ID" value="XP_038059518.1"/>
        <property type="gene ID" value="LOC119730602"/>
    </dbReference>
    <dbReference type="GeneID" id="119730602"/>
    <dbReference type="OMA" id="NAINDCT"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037645231" evidence="10">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="134" mass="14835" checksum="C1813A954D91B6BA" modified="2023-02-22" version="1">MKLEIASVIALICCSLIVSTSAQTKPTCAQLQQWNIPYFQCQSGDECYFKWYECDSILDCTDFPDENHCQTEHTVNCEKDFLGKKTSNGEPLQSFQCDNGMCILGCQRCDGVMDCADNSDESGCSGTEVIPPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A6Z9</accession>
    <name>A0A914A6Z9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038059642.1">
        <property type="nucleotide sequence ID" value="XM_038203714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A6Z9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038203714.1">
        <property type="protein sequence ID" value="XP_038059642.1"/>
        <property type="gene ID" value="LOC119730710"/>
    </dbReference>
    <dbReference type="GeneID" id="119730710"/>
    <dbReference type="OrthoDB" id="66533at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038059642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="177" mass="19579" checksum="416B496C5C9A51D9" modified="2023-02-22" version="1">MILSNPQTACQGKVQGALPPIKSKLKSCENSLHVRINAALALSIPTHRSCYGDIDRFCLVWSSIVHALEVIDQVADVSELKYKDTLRDQLCQTLTHLGGLIGQDDLSPLHKLMKDRTDMLESHLSRYRGAKLTTVDDTRGALLSAASVHLQDLMNIKDITAEDRNCAAQLVRMFAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A8L6</accession>
    <name>A0A914A8L6_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060108.1">
        <property type="nucleotide sequence ID" value="XM_038204180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A8L6"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204180.1">
        <property type="protein sequence ID" value="XP_038060108.1"/>
        <property type="gene ID" value="LOC119731147"/>
    </dbReference>
    <dbReference type="GeneID" id="119731147"/>
    <dbReference type="CTD" id="51138"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000130">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041406">
        <property type="entry name" value="CSN4_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18420">
        <property type="entry name" value="CSN4_RPN5_eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="197"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="405" mass="46006" checksum="86E769EF9EBF5A7A" modified="2023-02-22" version="1">MAASIKRQLSALVNTGSAPKDLTEKYRKILTDIMKLKDTALVEGLQALIEALVYESVSLVISRQLLTEVSNQLGTLSDVLSKKVSHFMIEKVQPRVVSFEEQVATVRQHLAGIFEREQSWRDAANILVGIPLESGQKQYSVDYKLETYLKIARLYLEDDDPVNAEAYIKRASLLQAESTNEQLHIHYKVCYARVLDYRRKFIEAAQRYNELSFKTIIAEEERMQALKHALHCTILASAGQQRSRMLATLFKDERCQQLPSYGILEKMYLDRIIRGNQLQEFAALLQPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGSLLEIPPAKAEKIASQMISEGRMNGSIDQIDSIVHFESRETLPQWDKQIQNLCLQVNTIIEKINQHAPDWIASVSETQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9T1</accession>
    <name>A0A914A9T1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038060523.1">
        <property type="nucleotide sequence ID" value="XM_038204595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9T1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204595.1">
        <property type="protein sequence ID" value="XP_038060523.1"/>
        <property type="gene ID" value="LOC119731425"/>
    </dbReference>
    <dbReference type="GeneID" id="119731425"/>
    <dbReference type="OMA" id="SEANPWI"/>
    <dbReference type="OrthoDB" id="5985199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="17253" checksum="BE7BD4574353A68F" modified="2023-02-22" version="1">MEDGRIPDASITASSVWSNHADYGPTRARLNLRATNGAAVWCNAGASEANPWIQVDLGSNATITGVITQGRADYHDWVTEFKVAYSDDGQEWTTVTDDGSCRPTPMKFPGNSDQNTHVTTTFPRSFQARFLRILPTKYHRFCCMRFEVLGCTLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914A9U0</accession>
    <name>A0A914A9U0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038060174.1">
        <property type="nucleotide sequence ID" value="XM_038204246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914A9U0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038204246.1">
        <property type="protein sequence ID" value="XP_038060174.1"/>
        <property type="gene ID" value="LOC119731178"/>
    </dbReference>
    <dbReference type="GeneID" id="119731178"/>
    <dbReference type="CTD" id="10399"/>
    <dbReference type="OMA" id="AQVPYCV"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000615">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038060174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="319" mass="35680" checksum="F7C646536F041056" modified="2023-02-22" version="1">MTMNEKVIMKGTLKGHSGWVTQIATTPAFPDIILSSSRDKSVIMWKLTRDENNYGVPTKRLKGHSHFVSDIVMSSDGQFALSCSWDKTLRLWDLGTGKSTRTFVGHTKDVLSVAFSQDNRQIVSGSRDKTIKLWNTLGVCKYTIQDDSHKDWVSCVRFSPNQVNPIIVSASSDKVVKVWNLTNCRLKTNHYGHTGFLNCVTVSPDGSLCASGGRDGQAMLWDLNEGKHLYTLDGADEINALCFSPNRYWLCAATGPSIKIWDLEEKCIVDELKLEVINPNSKSPQLSCLCMAWSADGQTLFAGYTDNIIRVWQVYQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ACN9</accession>
    <name>A0A914ACN9_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038061114.1">
        <property type="nucleotide sequence ID" value="XM_038205186.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038205186.1">
        <property type="protein sequence ID" value="XP_038061114.1"/>
        <property type="gene ID" value="LOC119731899"/>
    </dbReference>
    <dbReference type="GeneID" id="119731899"/>
    <dbReference type="OMA" id="EDNSANT"/>
    <dbReference type="OrthoDB" id="10052339at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038061114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1294" mass="146662" checksum="B54BF3881D902AEA" modified="2023-02-22" version="1">MAYAVTSTPSVEKDTVSNGGSVKSTQSDKGSRMTDTRAPTPPTQDDNVSEHGSVRSNRSMRSSCSVASIEKYREAKARLEITKLRKEQLKRKQQLAQQKMMLEMKFQLQNAEDEEEQAELETHIWGEEMQEEDATEDRPDVTQAIDTSVEVTSSTLVVNNHDRAQADMIDESGIITFPSNTTEESVTPPEVTSQSTPASNDHGSITQLCQALTLAMNIPKPDIKSFSGDPAEYWAFVTSFETNIGSKVTDARTRLTYLVQFCRGKAKESIENCILMEPTDGYKTALKILREQFGQPHLIMHALLRKVTNRGQIRQNDGNALWDLARDMEKCQITFSQLGYNADMNSSENLLKVQRLLPVHLQADWAKKAQGTIECKREPRFAQMTEFIETKAKTASNMYGQNITKTFSPTSASHSPRTKPKTYPAKVTALSTSVSGDYLHEAKKDKQVKCLCCSQQHKLAECKTFKQGSYDERRIDVSLCDEELAEQLGIRGERFNFSLNTVGGTSKYHGMEINLTVKSIQNDEELDLPRVRTVQTLPTSSSVFPNQKDVKKWRHLDGIEFPQTDGRPVQVLIGGDVPEAFWVMEERRDGRKEPYGVRSLLGWTLVGPTSPSFKQGAGSFNINHAKLQDDQLQQQVQRFWEVDFGGSIMDNKRGDSVEDRRARSTMEESARLINGHYKIGLPLRRRNPDLPDNRALAETRLGSLKKCLQKDDDLRQQYKETIDGYVQRGYARPVPEEVPNVEVGRKWYLPHHPVFHPQKPGKMRVVFDCAARFRGTSLNDNLLQGPDLTNNLVGVLTRFRHETVALVADVEAMFHQVRVPERDCDALRFLWWPSYDLSKDPTDFQMLVHLFGATSSPSCAGFALRKTADDYGAEFGEAATSAVRDNFYVDDLLVSVSCAEAGINLARQLIDLLSKGGFRLRKWISNNQEVLSAIPATPFILPAKILLQDICSKKLGCDERVEERELFRWKRWLDDLPRLEALTIPRCLRPRELEDTAISQLHFFSDAFERGYATVAYLRTVDGSGRIDCSFIIGKARLCPKRSISIPRLELTAAVLSVQLSKMVQEELRLPITDIVFWTDSTSVLQYIRNESRRFRTFVANRVARIQDATDESQWRYVNSESNPADEGSRGLSAERMIKDGRWLKGPQFLMMNEDHWPIPPVVLQGTVPNPDILPLNDALERDPELKRVVTQTALVQEKLKVDEFLAKYSSWNRLKRGVSWLLRFVQYLHIRCKGIADDSSLKQGGFSVEECQSAERGIIRYIQRQAFPKEKDALHSTKQETATCEKKSRGQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AE90</accession>
    <name>A0A914AE90_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062058.1">
        <property type="nucleotide sequence ID" value="XM_038206130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AE90"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206130.1">
        <property type="protein sequence ID" value="XP_038062058.1"/>
        <property type="gene ID" value="LOC119732559"/>
    </dbReference>
    <dbReference type="GeneID" id="119732559"/>
    <dbReference type="OMA" id="CGGVKHP"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="25966" checksum="B5BC8D7440E36E06" modified="2023-02-22" version="1">MKCSLKWSSNYSRNITCTNCSRLTNCSRATSISRSTSSSCSTSSSRSTSSSRSTSRSRSTSRSRSTSRGRSTSSSRSTSRSRSTSRSRSTSRSRSTSRSRSTSSSRSTSRSRSTSSSRSTSSSHSTSRSRSTSRSRFTSRSRSTSSSRSTSSSRSVSSSRSTSRSRSTSRSRSTSRSRSTSSSRSTSSSRSTSRSRSTSRSRSTSSSRSTSSSRSTSSSRSTSRSRSTSSSRSASRGRSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AF52</accession>
    <name>A0A914AF52_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062600.1">
        <property type="nucleotide sequence ID" value="XM_038206672.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038206672.1">
        <property type="protein sequence ID" value="XP_038062600.1"/>
        <property type="gene ID" value="LOC119733093"/>
    </dbReference>
    <dbReference type="GeneID" id="119733093"/>
    <dbReference type="OMA" id="HIHQTAF"/>
    <dbReference type="OrthoDB" id="10056126at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1646" mass="186475" checksum="621E88B6DC7E6F49" modified="2023-02-22" version="1">MEVPNFGGGDPAEFRCFEAMIDGCIKPLVHLSELQKYFIVRSKLSGQPKKDVLGLEHDGSPFTKAMSTLKKLYGDIGVLIRAKIDQITSWPRLTASDSKGMVEFAAAVSALVTQLKSAPEGQAELNANSTACILYSRLSHIHQTAFLKAMKARNVNNFSLLDINMWLQDTAAIARKKVQLSESIKVELPPTNRDRRRKGAAAYHMELAGKTTSNPPKGASAYKAYRSDGKKPFRKSCPHCREEHWLSRCDKFSDLTMEQRMKWIKADKRCWQCARLHKNGKECDLRKPCRRCDKMHLTVLHDMMEQPGYGVYYSSFDPNLSVFYGDGNPWLPDVSMKILPVKLYANGRQLETYCLLDDAANFSLMLSKATEALGLKGESTQMPIATAREECTPCKGVIVSVDLAPIHDQDSRITISNVFSSSMLRLSEHSVPARDLQRRWPHLRGLPLQEVKEARPLLLIGSDRPDLIVPIESHFGPEGAPVAVRTKLGWAVQGPILKSRRKNEVNFLSVLPPMEADRVLHENVCKMWQHDAQMYLDRKQATRSKQDQRAVDLLEAKSTYVNVDGIDRVATPLLWTRDNEVLTCPASTVSPALKRNEQRLQRDPALAVEHSKKIRELKEAGLVRMLTAEEKERNHERHWYIPHHVVRQNGKTRLVFNCAFPYRGESLNDHLLPGPTLGSPLVGVLVRFRQHQVAVSGDIKAMFHCVRTLECDRCMLRFLWRDLDPDAEMEELEWNVLPFGTTCSPCCATFALQKHVQDRFPDPDIVRSVMNSFYVDNCLDGKSSVLEAKDLVGKLCQALGAGGFPIVKWASNFAEVVRDLPQEARSCSTERWLSSSCDSPEEAALGPHWNFQHDTLRYKLELREWPVLTQRAVLSDVMRCAGKDPLGYLMPYMVRGKMIVQELWKRPWGWDEEIPDEGKDGFRAQHMRWRKEINDLPLVYLPRCYLPPHFDPANVSYQLHVFTDASERAYGSVAYLRAIAKSGEVCVRFVMARSRLAPKRVQTIPRLELQAALSGAELTELLEDELRLSLSVTCWSDSTTVLSWITSESCRYNRFVGARIAEIQRLTDHTIWRYVDTAKNPADDLTRGLMLSELTTESRWSAPPFLSGPEEDWPSLPSHMQQDDGEVELKGSLFTAFTLGNRGEVPEIEASQFASWDDLVEAYGRILCEAEDETKPDFLSADQRMETEQALFGKVQAESFPVDLAPLTAGKPVPRNSRLAKLAPEIDKDTQLIRVGGRLRRAELDIDVKHPVVLDCKHPIVQLLIKNADERLGHPGTGTVLADMRRRFWLLRGRQSIRGLQSRCTGCLRQRGQPSVPKMADMPHARLRIGKPAFYSTGVDCFGPYTVTMGRRSERRWGIIWKCMTTRAVYLDLLESLDADAFLLAFNRFRSRRGAPHELLYDNGTNFKGGLSELRKAFSDMAPDLQERLAKYKVNFRFNPPSAPHFGGTWEREIRSVKTALYATLGDRSVSAPVLYTCLVEVEALLNSKPLTYVSSDIADPDPITPFMLLMGRRDHAPPQVVYPERDVLSRRRWRQCQALIQKFWKEFVQSYLSAMQARQKWRSETDNLSVGDVVLMADPQQRRASWPLAKVTEVLPGTDNRVHTVRLQVGDRIYTRPVARLIRLSSETALGGNPEAATLPEPDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AG71</accession>
    <name>A0A914AG71_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062717.1">
        <property type="nucleotide sequence ID" value="XM_038206789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AG71"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206789.1">
        <property type="protein sequence ID" value="XP_038062717.1"/>
        <property type="gene ID" value="LOC119733199"/>
    </dbReference>
    <dbReference type="GeneID" id="119733199"/>
    <dbReference type="OMA" id="THFADEN"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037551792" evidence="1">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="164" mass="18132" checksum="9EA86804FCBF057B" modified="2023-02-22" version="1">MLLLCILCLMVSGQVNGNWADGSKDPDHSNLGFDAVNMACNEDKTACGDCYTARSHGLVYLNVFEYTADPYKVQASIEDGIQDWDWTFIQDDPSQLFRFCKEIKVSSTPELPLPMRASLCIDNDFSGIDVPSDCATPVATVTMDTHFADENINGQQTLYCIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AGD5</accession>
    <name>A0A914AGD5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038062777.1">
        <property type="nucleotide sequence ID" value="XM_038206849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AGD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038206849.1">
        <property type="protein sequence ID" value="XP_038062777.1"/>
        <property type="gene ID" value="LOC119733262"/>
    </dbReference>
    <dbReference type="GeneID" id="119733262"/>
    <dbReference type="OrthoDB" id="10106457at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Vitellogenin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038062777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="214" mass="23922" checksum="363201B487C371A0" modified="2023-02-22" version="1">MALPAGRTNLRFGVTMLKLALVLSISTSWISPVLASFIRFKPDTEYVYTFHSSTELKMVQTLQTESKIGFVLVKSSNNSSGLQEIYLRVHSVVVTSQEERVHLSEERDFTDWFSFDISENGAIGQVYFPGDQDDLVIGIKKGLVSLLAANLQHPPQEQVLGSDWSYDCNETGHEGQHESSYTAQMAPGNDGIIVFTKTRRTHPIPYGKSKHQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AI60</accession>
    <name>A0A914AI60_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038063226.1">
        <property type="nucleotide sequence ID" value="XM_038207298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AI60"/>
    <dbReference type="EnsemblMetazoa" id="XM_038207298.1">
        <property type="protein sequence ID" value="XP_038063226.1"/>
        <property type="gene ID" value="LOC119733937"/>
    </dbReference>
    <dbReference type="GeneID" id="119733937"/>
    <dbReference type="OMA" id="KVCCIGG"/>
    <dbReference type="OrthoDB" id="2126785at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="417" mass="47445" checksum="36088626D96BF07F" modified="2023-02-22" version="1">MTKTMDSPQVHHAADFARGLLTNVLDDLLSQVDGSSKTDRIKESLGSIREIYQKRLSCASSQYRTDWNDPANRCAYVFLYLLQHCHLVCTSLQINSEEILTAWRRKSNLKVCCIGGGPGSDLVGLTTFLRENNIFPSKLECLVLDLYPSWEDAWMSISEYIPCPDRVGVAYRPCNVVNDTLVLNDVREFIKQADMLTFVKSFSAVSAFFRKDSRRGNLLRSFLRDIKPGCFVLFIDNEHVSDGHFQQEFASRVGLELVFERRGAQTVPRGTYSQTIKKYCRLLECQPMRTCDVIIQLFRKKVPVEVLRSTIPERPSSSTAQRAKAPQHPSHQHRSQEVEAVRSTIHNRPSSSTARRSQTPPRPSHQYRSQDYSYNYREPGIPRSTSHDNEGLSWTEAGIILGVGVGALLLISLWRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AJV3</accession>
    <name>A0A914AJV3_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063831.1">
        <property type="nucleotide sequence ID" value="XM_038207903.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038207903.1">
        <property type="protein sequence ID" value="XP_038063831.1"/>
        <property type="gene ID" value="LOC119734406"/>
    </dbReference>
    <dbReference type="GeneID" id="119734406"/>
    <dbReference type="OMA" id="GVTNLNC"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF16">
        <property type="entry name" value="FIBRILLIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2481"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="16">
        <location>
            <begin position="212"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="15">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="17">
        <location>
            <begin position="522"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="888"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1113"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1155"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1279"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1358"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1403"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1447"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1489"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1535"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1577"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1664"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1706"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1866"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1906"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1945"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2422"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2529"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2529"/>
            <end position="2540"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1895"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1934"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1975"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2431"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="2450"/>
            <end position="2459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="2617" mass="282215" checksum="D0954500B0B5CB9F" modified="2023-02-22" version="1">MPLTGGWWYLQYYTHVHTCVVTNNAGCTAVGAFDFYVFAQPRITVPSVADQCTLPGQNDVVVSWPAVTGTYLDGQSISCTNQNGNAVPLSGGMSFGLGSHTVTCGVTVEICSTSRSFSFSVYEGNFVPFGVAVGDSRLSEETQPSSLSSNKDMISRTISPPNFFPFCNELHEKIYFTDNGVIVFSNEQSLYKRSYPSTTKTFFSGPTKMVAPFWADVNSRRFFPTRDVFFQVYDDSSSTMLSTLSGIVTAHYDCSFTAAWALVITWRYVEALSPDKSTNSFQAVLVTDYTHGYVIFNYERCGMNWNKDLLPNDNVIQGFTCGQPGTEFYLDIPSDLRFRPGNMVGNTGIYGRWVHRLDSLSDDFVNPRLFCRNWYSEQVVDNFILSYWFATAHTCPCSWFQAIFDPRWAYIGYSYFLPDSGSSSSVAAVCYVRTFQFPNTPGPLCCYSTQTWSLLRGVRNAIVASVFEHYPVSPLFYTPSLFNQWFDKEVLPRYYCCSASTLCNLYNYYRPAMSCWRYQPPFWFWFWGDPHIKTLDGVEYTFNGLGEYTVALIQDDNGGIIFELQGRTQRATNVETGQLTDATFYSGFAAEYPGEGRVEVKLNKRENADGLITTVNGDVVTPTTAGLLIGNVTVKRDASTNKVVTMFPGDIQFTVGVNNSIGDITVQFGQTYRGKTKGLLGIWDGDQSNDATRRGGAIQPATGAGGAMIESDFYEFGETWRITEANSLFYYVSDETWALSNEHSFVPSFYEDLVAAATPEKLARAQELCGDNKMCLFDTLATADESIGQSTVMLNEMNSASESAATNFPPNITASDTFRVMVGVQFTEQLEAVDPDGDDVTFALVEPIEGASITEDGGLFTWTPADKSKVMVGFLATDGKANGTHEPTVQICDCMNGGTCLWDEFVMGTDVVEDRFGVVLCECDPGWSGEFCEVDFDACEDGPCFMGVACFDEVPPSLNNTCGPCPQGLEGDGRFCQDIDECELYQDEPASSGGQGCDQICNNLLMDYNCSCESGYSLYIDNRRCIDIDECELDLHNCSVNAVCNNTQGSYECDCKPGFRDDFMDGTSCTDLLECMDNSTYTCDEKANCENTIGSYMCVCIAGYEGDGKTCQDLNECTRNLDDNCHAEADCTNTVGSYTCACGDGWTGDGTNCTNVDECAASLPVCHENAECTDTQGSFICQCNTGYVGNGVMCTDLNECTTGQDDCMAVTGECSNTVGSFDCSCKDGYTGDGRTNCTDIDECQGSNDCSPNANCTNTVGSYQCDCVTGYTGDGQTCTDIDECTLGLDDCQQECSNTEGSFTCNCSTGFTLQEGVCRAGMMCLNTNCTQGDCYRASNADMCRCYSGYAADGDLTVCEDIDECTSQSDPHMCGANSMCDNLDGSYECSCYPGYTLNSDQRTCSDVNECQAGTDNCDAMSQMCVNDEPYFTCDCQPGFSSEFFNGSCSDINECLNDTLNDCHIDADCLNNNGSFTCQCKDGFTGTGQLCFDIDECSLPTNDPNYANCSPFASCTNLVGSFQCNCTMGYEGDGQTCENVDECESGIPVCATNSTCTDNPGSYLCTCDDGFRGDGFTSCVNINECQENPGVCHSLATCTDTEGSYRCDCNQGYQGNGTYCEDVNECMTGTDECAANIAECTNNVGSYMCSCIEGYVSAGFPAGRQCDDVDECALNTDTCETSTSQCNNTIGSYVCDCLEGYEKILGQCEDVNECNGGTPCTMVNSMCANLPGTYECNCMLGFYQEGATCRAAYSKASSAVFEIISGLAVGGAGFDLATGSVTYRQDLKNSMEAAFIASSLTSSFRDVVITDLTLNSDSSTALLELVINFDSGSGHSDLDIIMALLGQVTGGNGGQLAPNHQLIRRTFIIGDPKCDSAPCENSGECVEDNLATGGYTCSCPPGYSGQNCQVAPCDVNPCMNSGNCAVDSTSDTGYTCSCGQGFSGPQCETIAPCQMGNDCVNGATCNDALNNPRGYTCSCDVGFMGENCEIECTLSCANSGELDLAECTCACTDNWSGLSCNDCALDCMNGGNVNQATCQCTCINDWSGTTCTECSLSSCPPGENLFTSTCQCSACSSTCLNNGVQDQTTCECTCDSDQNWTGNDCSVCPLECANGAQLNSQTCECPCTGNWMGTRCSDCQLICANAGNLDSETCQCSCTGSWTGTTCSDCQISCANGGTPNDGTCQCQCDQNWMGNTCTDCNLNCMNGGTLNTATCQCSCAQSWTGADCSACPLSASSCLNGGEFDSDFCECRCPYAYAEPTCAAANPCLSDTSLCPNAAGKFCQPATNAVGYTCECNGYQGFFTNSDGSCTQRGSALRFVMSLDLLFLSAYRNPAAAAWKQLARRVVSAILSKLRGDSLTNRVIAVQVLRFESGSVVTHIALAFQGQQPSVDVITNVIAAGGTINDGVTDIALVPDSVSYTNTSLLSDCTQDGCMNGGTCERTGFNPQLTCSCPASFTGDQCETPVPTTAPETTAAPGGGVSPLATVLIIVGCVVLLLAIAGIAMCFCMLMRRQYSKAQYYHQSSRQFRSSREPFDFGDRSVSSDEGYSATDYREEERRMNRLAHVMSQSPYIQSMQNRQDFIRPYVVTGNEALERYRENEARDGRAHAGRTVYNPALYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK76</accession>
    <name>A0A914AK76_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038063971.1">
        <property type="nucleotide sequence ID" value="XM_038208043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK76"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208043.1">
        <property type="protein sequence ID" value="XP_038063971.1"/>
        <property type="gene ID" value="LOC119734507"/>
    </dbReference>
    <dbReference type="GeneID" id="119734507"/>
    <dbReference type="OMA" id="CESGNSI"/>
    <dbReference type="OrthoDB" id="8603363at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF103">
        <property type="entry name" value="BETA_GAMMA CRYSTALLIN 'GREEK KEY' DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038063971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="347" mass="39202" checksum="784F2620065D1F29" modified="2023-02-22" version="1">MTAKITLYQDSNFRGASRDVTGDISKLSSIGFNDRVSSIKVVGSVWVGYEHTNYNGRQYILEEGDYPNWGAWKGSNDQLSSLKKLNPDIGDLPQIVLYQHTNYGGRAATFTYGIYNLKYYNFNDDASSLKVKSGIWILYEHSNYGGRQYVVTEGSYPHWDNWRGANDKISSLRPIKEPFFPTEVLSMEFDIAAGLLNSTPVALVNLSQRNDSSSDQQASWSTKRTVTTTKTYEWHWQNSTAVSVSTTFKTGVPVIADGEITVSVENTFSIGENRGQQNTQSDEWSFNLPATVKAKTMLRVQVNIQQGKIDVPFSALLQKGNRRWREVGTFRGTQSYNQHVDYDETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AK84</accession>
    <name>A0A914AK84_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064142.1">
        <property type="nucleotide sequence ID" value="XM_038208214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AK84"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208214.1">
        <property type="protein sequence ID" value="XP_038064142.1"/>
        <property type="gene ID" value="LOC119734685"/>
    </dbReference>
    <dbReference type="GeneID" id="119734685"/>
    <dbReference type="OMA" id="MKVHTEM"/>
    <dbReference type="OrthoDB" id="6075577at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="220"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="382"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1061" mass="118360" checksum="2AEC55043A2D57A0" modified="2023-02-22" version="1">MSSFLVVDRLIVDTQSTGQCCIELCQGDITQLDVKDKVDVLCVSVFGSSYSPSSHTLVGALNKKLNLSVKRLAKDKEEDLRHAYMCWWSKPLPENLPFRKLLCFENRGRLFRPQELVANVFRCLVPILNNEPGTVISPLLNTGGQGRDEATMLVGMVEAAIKWMKAGLPLKQLKIVLYANVIKGKVITVHMRDQEGIMKAFRDLKKKHNRQIFIPMAVPLEYDIYLSHSAADGQIASMVETKFRASKPDIRIYKSEEVPVENAEDKAETEGSFWQEDLFKIMSRCARVVPILSPAFLESKACVDLYNMALCCNRRAQRDLLAPLYIEKIEDMPTYMGLVQYIDCSPKDEAKISEGCEHLVQSLAHSSMKVHTEMVIADTSPLHYDVFVSYSHQDSRLAAPIVEKLQKMNPELRIFFDIQELKAGTAWQKMLYHAIDGCRSFMALVSNSYMKSAMCIEEFNLALAKHCSSDSRLCLVPVCIEPLVDPLPEFQQVKLINATPDVFDPAVEIICNSLVDWIAGRDWSPLLDSIFRKKMRKTVDASEYAMERRRLEFTLKYGKGEKILKRDDVTYPPSLQGVYSPSPLADDTNTNDKPCDVAFSCSPEDKKFVNYMTKILRKVSPGLVIKETADTENERLALMESARKVVVFLSANYLESVQQVEEFHTVLLRQRYRSPTQVLFPIILHNLPQLPTYFHLVPCEFNLFDPMWMDLYTKYLIIKDLRKMDQVHLSHELERSESIAVIAATHSLLGQLKTESELPPAAKTSQEPMLLNVMLLSSEVSRLHKKVRNVDEVDADKFGNVSNEGNADAGSLEDFLLNIVELPLATEDLATGASDAGISSVSDLESTSPDTQARDGDEAVSIHEFTQTPQTAMSSTEAKSKNGNNSNDRYFPDKNPDITVNSKEQSMNESHTKNGEMEDISPIDEPLVGLDGQPQVNNAGKNEDQSQQDFQSRVEPSSESATNIGSSMPIKHTDDVSVKPASASEQGPPNEGSNTTHLSAPSSSRGNEKDGLDAVSSQEEADDGTPVDGPYVLHQKTQSPSLGAQSAESTPVPSTSWCNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AM24</accession>
    <name>A0A914AM24_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064792.1">
        <property type="nucleotide sequence ID" value="XM_038208864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AM24"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208864.1">
        <property type="protein sequence ID" value="XP_038064792.1"/>
        <property type="gene ID" value="LOC119735160"/>
    </dbReference>
    <dbReference type="GeneID" id="119735160"/>
    <dbReference type="OrthoDB" id="2019614at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029131">
        <property type="entry name" value="HAUS5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28588:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14817">
        <property type="entry name" value="HAUS5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="439" mass="49138" checksum="F3C5456B44BB66E7" modified="2023-02-22" version="1">MSVLHKWATMEMNFVPQGRHVNAPMPTPQELRGICRGGLLDIWEFVNARVHSAQTARKVKGNLPVALLARHRSGSGYKVKYGGDTKYSQERAELLERQRGLRSQLEGTKADVKRLGKDLGISRLESEILSAEQEYQTSCSEISYLQHKQTLLGAHSAECKANTARYEEYTKRIAGKLNRYKELKSGHGQSLLFSKQGSSQTNGTSSPGLESACTKIVHESSSEVASFLNQLLKGDFGSDSKALANGIGWLEKQLAHMRTFMVTEQSRNSAWRLDKRLAQLVSQVHRRLAALLADNPGASEMARTLFTTELELVSATAALEQLRDSCRELQESASKASKEKDCLYSKYQKIQDFKKLTEKKQDLIRVLVRQNSEAKKKLEVLQRENLNYMQSTLCSHEAGTVAMATQMRNGVSEEVERFAQLPLHLLRLTSLDSCISSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AME7</accession>
    <name>A0A914AME7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064581.1">
        <property type="nucleotide sequence ID" value="XM_038208653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064588.1">
        <property type="nucleotide sequence ID" value="XM_038208660.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064596.1">
        <property type="nucleotide sequence ID" value="XM_038208668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038064604.1">
        <property type="nucleotide sequence ID" value="XM_038208676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AME7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208653.1">
        <property type="protein sequence ID" value="XP_038064581.1"/>
        <property type="gene ID" value="LOC119734983"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208660.1">
        <property type="protein sequence ID" value="XP_038064588.1"/>
        <property type="gene ID" value="LOC119734983"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208668.1">
        <property type="protein sequence ID" value="XP_038064596.1"/>
        <property type="gene ID" value="LOC119734983"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038208676.1">
        <property type="protein sequence ID" value="XP_038064604.1"/>
        <property type="gene ID" value="LOC119734983"/>
    </dbReference>
    <dbReference type="GeneID" id="119734983"/>
    <dbReference type="OMA" id="NNNFVIM"/>
    <dbReference type="OrthoDB" id="1357022at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070513">
        <property type="term" value="F:death domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="155" mass="17615" checksum="6AF3430C59466E6E" modified="2023-02-22" version="1">MEDSDKRRLRRNRCALVDNIEPSRILDHLIECEVFTPDMCQDITSKSTTKEQTGKLLNMLEKRGCDAYRLFRNTLLKTDYEHLVEKLDTTPTADEVDAKAIKSPGQGQISSIFIPGHQKKQDAQHITNNVIGDNNFAVFGSQNLTINNYNEEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMG8</accession>
    <name>A0A914AMG8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064932.1">
        <property type="nucleotide sequence ID" value="XM_038209004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209004.1">
        <property type="protein sequence ID" value="XP_038064932.1"/>
        <property type="gene ID" value="LOC119735305"/>
    </dbReference>
    <dbReference type="GeneID" id="119735305"/>
    <dbReference type="OMA" id="MACADCT"/>
    <dbReference type="OrthoDB" id="10443538at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037779900" description="Immunoglobulin V-set domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26215" checksum="2390CC30DCB23C7C" modified="2023-02-22" version="1">MACADCTAVVWGLLQAIVSAMEGSSKFATKSGLVECAVEGNSLPAVAWYGPNGTAVTNHSSTGQISLEDTITGARVVGYIVKSRLTIDQGQIGNGYGMYRFSATNSMGTFNGHQIQLTKTEEIYLVTPSPYPVDSSGLFQDVSARVVLAATIGGALVLTLVAVCCCWHRLGCAKRNVRGESRPTSTEPSLDDSFDNDAPPSYEEVIEMDSDIGDMDDFPPEYELLREPPTAGLCTDEIQEDEHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AMK8</accession>
    <name>A0A914AMK8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_038064972.1">
        <property type="nucleotide sequence ID" value="XM_038209044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AMK8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209044.1">
        <property type="protein sequence ID" value="XP_038064972.1"/>
        <property type="gene ID" value="LOC119735348"/>
    </dbReference>
    <dbReference type="GeneID" id="119735348"/>
    <dbReference type="OMA" id="RCLDICV"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038064972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="264" mass="29691" checksum="D305FB48CE76F19C" modified="2023-02-22" version="1">AAYANTPTTHKAFPRDQLNIIKELGHGAFGQVLLAEASGMTQGSKVTLVAVKTLKDGAGQSDKADLIRELDLMKKLPDHCNVVRLLGFCVEEDPPYIIVEYQSRGNLKDLLEDSRNKRRRVYGNRHGLSNTSKDLMKFAKDVADGMAFISSQRCIHRDLAARNVLVAEDMTCKVSDFGLARDVMDVRVYERRSQGPLPMRWMALESILNDVYTTESDVWSYGVLLWEIVTLGARPYPAMAPSEMIDKLQSGYRMPKPQHCQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ANH0</accession>
    <name>A0A914ANH0_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038065046.1">
        <property type="nucleotide sequence ID" value="XM_038209118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ANH0"/>
    <dbReference type="EnsemblMetazoa" id="XM_038209118.1">
        <property type="protein sequence ID" value="XP_038065046.1"/>
        <property type="gene ID" value="LOC119735418"/>
    </dbReference>
    <dbReference type="GeneID" id="119735418"/>
    <dbReference type="OMA" id="IAMHQEN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12100">
        <property type="entry name" value="DD_CABYR_SP17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047579">
        <property type="entry name" value="DD_CABYR_SP17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="2">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038065046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="224" mass="24896" checksum="EC1E64C08A8EBFDE" modified="2023-02-22" version="1">MSMRYGPVELSVPPGFQNILHLISQEVLREKPANTLEFIARFLDDLLAIREASGYDPVTQGEMINRVQEQYWKIVKMRKNSKLISENEMMEKTVESTPEVWGGSGDIAAPASVEENAEVLVTIAMHQENGEGTEQYQPTDEEMVDEPHLVTEQPEAVAEQPEAAPDDEQAVGSAEDTTQKEEGENLEGQDEGIEDTTDQVAMATEEEVETPAETGEVDEKNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQV8</accession>
    <name>A0A914AQV8_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066038.1">
        <property type="nucleotide sequence ID" value="XM_038210110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210110.1">
        <property type="protein sequence ID" value="XP_038066038.1"/>
        <property type="gene ID" value="LOC119736102"/>
    </dbReference>
    <dbReference type="GeneID" id="119736102"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="249"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="532" mass="59485" checksum="0C57148800702973" modified="2023-02-22" version="1">MVVIGSTAIIETEQSQACVKLTQNSPIFVQDFKRCLGSTAAAQGAPGMPWFNSMDAQVILSKFVGDTATLKCTVEDKGNRDVAWLRTEPHSNIIFTRDEMYDSDPRYKIDTDNNRTFHLRIERLTRADNGTYACTVNTKPVISWNVTLQIVAPATVTDIVQMSQGVSDSGKRTFFFNESDTVELKCNGDGSPQARLAWIGPAGDQVGNSTLRIDGIQRSQYGEYRCEADNGFNDIPDARLVTLKVNYKPEIRVYQTDIEIRKAVGEYVKMLCRADASPRATYTWRKDGVLVPPASRINNRQTILVIVSIQPEHYGVYTCEATNLLGTSRANITLNGKPLPPIIVSDPVGTRRHIFKLMWQHQSKQPPNYPGTIPVTYYKILYRGWWRQSTQDRRKVYSLEDETNLMEEIAYPDFSKIKQFCNLHDLRHNATYDLQLYAVNDQGDSDPVNFTFYTALARADYNATSEDEVTTSNGDTAGPLSLSSINENQDPNREGLKWTAPSIAPSSAPSTATVLAMVIALALGLHCTEVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQX2</accession>
    <name>A0A914AQX2_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066053.1">
        <property type="nucleotide sequence ID" value="XM_038210125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQX2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210125.1">
        <property type="protein sequence ID" value="XP_038066053.1"/>
        <property type="gene ID" value="LOC119736108"/>
    </dbReference>
    <dbReference type="GeneID" id="119736108"/>
    <dbReference type="OMA" id="NWNTEAN"/>
    <dbReference type="OrthoDB" id="6134084at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037572375" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="256" mass="28831" checksum="8CD27924FBC75F62" modified="2023-02-22" version="1">MKFVLVAMLVVVAQRCLIGTTARTDKRSESTLDQALRPLYSQIDTFRYQLDAVKALGSVHCNKASEWQLVFKGMAGKGVKLYGMWTAASWDDNTMGVSGSWRDESLHDSWKSGELSVRRVKLSLHDFEGRRVDLIFNGIGTDIHNWFTQERLISSPWQNLKSSTPDFFSTDGYIQEDRRFYINNIHNSCPGDRGWLVVIDSGITADCAWGRPSTAYPYPIILYSRLTGDVLWNNVISAGDVTVGHADFLTIHVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AQY2</accession>
    <name>A0A914AQY2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038066062.1">
        <property type="nucleotide sequence ID" value="XM_038210134.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038066063.1">
        <property type="nucleotide sequence ID" value="XM_038210135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AQY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210134.1">
        <property type="protein sequence ID" value="XP_038066062.1"/>
        <property type="gene ID" value="LOC119736122"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038210135.1">
        <property type="protein sequence ID" value="XP_038066063.1"/>
        <property type="gene ID" value="LOC119736122"/>
    </dbReference>
    <dbReference type="GeneID" id="119736122"/>
    <dbReference type="OMA" id="CEMASPK"/>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="269" mass="30822" checksum="76F8BCC83856EE80" modified="2023-02-22" version="1">MEMSASTISLLVISSCVFWSSLYGLFCYLCPQRSYEWNCRAVTLVHAVTIVVMSYIFGIYYNPWPFTHPGGKSSIHEVYTMVVCVGYFIFDFVWCVWFRDQESSVMLVHHLITIVGILAALAWEHSGTEVGATIFGAELSNPLLQMRWFMRQAGWKGSFLYEVNDFLFLLTFTVCRIGLGSYFLYCELLHPLPRMFFKVGAVALYLVSWVLMVNILVFTSRKYTKMYHGWTGKTVDGPHGQPLVDRNSTVHAKEDERVRMRNGYAAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914ARU7</accession>
    <name>A0A914ARU7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066174.1">
        <property type="nucleotide sequence ID" value="XM_038210246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914ARU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210246.1">
        <property type="protein sequence ID" value="XP_038066174.1"/>
        <property type="gene ID" value="LOC119736215"/>
    </dbReference>
    <dbReference type="GeneID" id="119736215"/>
    <dbReference type="OMA" id="HQQEAIM"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038007965" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14824" checksum="BD72D812D61AB8CA" modified="2023-02-22" version="1">MEVKPQNVVAVMFVTVCLVAVVQASRYGHFGEETCQPNEFCLGRRYRNIVQTCACPEEVHEIDGLLVSIPTQCQYDYRKRHFLCRPKVNYEGTDEHGRSPPRQLHIQTFQRFHQQEAIMSKGLHTFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS14</accession>
    <name>A0A914AS14_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_038066845.1">
        <property type="nucleotide sequence ID" value="XM_038210917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS14"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210917.1">
        <property type="protein sequence ID" value="XP_038066845.1"/>
        <property type="gene ID" value="LOC119736895"/>
    </dbReference>
    <dbReference type="GeneID" id="119736895"/>
    <dbReference type="OMA" id="CDNQPYI"/>
    <dbReference type="OrthoDB" id="5974690at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="136"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="475" mass="51327" checksum="B8C584F96EAA3C74" modified="2023-02-22" version="1">MISAESKPRDVANRASSCDNQPYISKKSPSNDSLSKASQAKKDTSSPQEAASERDAESSSSIANKASSGENHHSPRPKISTSSAWKDAAISDSTPGTANASSENSQATQDPQEGLPELTAYPSIDPSELEFIMSDNGKEVALGSGSCGGVLLMRNIEDNTPLAVKVLVKNFSDLQYEVAAMHAVMNCPYFPRFVGVIDYCSYAQELVGGVDSNMAFNFSKARNDYDLLYALEWLHVCRDVTEGLKALHAAGWLHNDLHWNNAMVCPNPPGSEVAWCGKIIDLGLASQISNPGPVAILDDEEQRRVYKYSKHCAPEILESRDAYNEKTDIYSLGHLFVHSVAGGANSLHGLRLLGESCMRRSPDARPTLEAVSGKLGDLITEMMQAEQQQPSSPTPIPPSSTSPSPNLRCHLIAEMMQAEEKPSSSTPIPPLSSSPPPNLRCHLIAEMMKVEQQPSSPSPIPTSSPSPSNLRRHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS17</accession>
    <name>A0A914AS17_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066171.1">
        <property type="nucleotide sequence ID" value="XM_038210243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS17"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210243.1">
        <property type="protein sequence ID" value="XP_038066171.1"/>
        <property type="gene ID" value="LOC119736210"/>
    </dbReference>
    <dbReference type="GeneID" id="119736210"/>
    <dbReference type="OMA" id="GHEEMEM"/>
    <dbReference type="OrthoDB" id="6133491at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="609" mass="69363" checksum="08FFCB8E3613FFAF" modified="2023-02-22" version="1">MSILRNGYMLPLFTLPEEAEIRNNRSAFDKFDFVGSEIEKLLLKGCIVEVSQKPYVVNPLTVAGNKDKPRLVLDCRHINPHLYKEKFKYEDAQVVRDLFKVNDFAITYDLKSAYHHIEITEEHRKFLGFAWEKEGKKKYYVFNVLPFGLSTAGYVFSKVMREVVAYWRSKGFKVVMFLDDGLAGSATREKAKGQSDFIRNSLKDLGFLIAEEKCDWEPKTKVVWLGLVWDFGHGVMHITEKRTKNLIYSINQLLSGLDAPFALVKARSLAGILGQIVSMHSVLGSLVQLKTREAFKCVNSRASWNASVVLASEAKSELIFWRDQVDQINSRSISEHMVVHSSVYTDASGIGCGGYGWGHEEMEMVGAWSQNEMGKSSTWRELEAVHRMMQDMAQGLEGPNVRVYTDNKNVVKIIKAGSNNSELQQKALQIREICSKVDMKVDPVWIPRADNKRADDLSRMADSDDWQIDHKTFARLDRCWGPHSCDRFACGYNSKCQKFNSRGWYPGTSGVDAFSQKWSNEMNWWVPPSKLIARTVDKCVAEKACGTLVVPYWQSAPFWPKVWNGSSFKPFVQAHEFLTSDVVWKGKGKNGIFGKRGSIFKLIALKIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AS55</accession>
    <name>A0A914AS55_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038066289.1">
        <property type="nucleotide sequence ID" value="XM_038210361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AS55"/>
    <dbReference type="EnsemblMetazoa" id="XM_038210361.1">
        <property type="protein sequence ID" value="XP_038066289.1"/>
        <property type="gene ID" value="LOC119736311"/>
    </dbReference>
    <dbReference type="GeneID" id="119736311"/>
    <dbReference type="OMA" id="RISWIAC"/>
    <dbReference type="OrthoDB" id="5987693at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="901"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="778"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="1073" mass="109672" checksum="65835E04E4CCF7FD" modified="2023-02-22" version="1">MWTIEGAIYNSSKWQPPLVKLRGSACLCMHYQTLIETYKCCPIPIVIGDVNTGKTTACRMASKMMGMNHHLGYAGERYLPKQTAASSFPVFIDDAEGKDIEGLMTKYFNGGLDATCSFESQPKTCPIVTANWFVLDKVAGNARAMSRALLVPFSKSERRMGERQCLDELERSEIEERAVHALPALVKIGKKLTKHKIDILTVYRSKVAKATKGINCEDRIHLCYGLLLFVTEHLIRKASLQYPPEAAEVFLQEAMVPRIKTFQSDITHTELHTGTSPDNRQLDIPGIIMQATRIFSLGELLMVINPHIDLRANAEQGTPADEGLGFHMNDMIQLFQKSNLPLHSKVAWRSAISADHLMRGKIQAFMNSDRCYSYIRRGRTDGSTNPRNRSAVFISYKRFNMQQLKQLQKVFKVKAGIDDSEDDSSESESSDFDMNAPTDSQSVQGGSALLAKTPVPAGNADPGVPAGNADPGAPACYADPGVPAGNADPGVPAGNADPGAPARNADPGAPACNADPGVPAGNADPGVPAGNADPGVSAGNADPGAPARNADPGAPACNADPGVPAGNADPGVPAGNADPGVPAGNADPGAPARNADPGAPACNADPGFPARNADPGAPVGNAVPGAPARNADPGAPARNADPGAPACNADPGVPAGNADPGVPAGNADPGVPAGNADPGVPARNADPGVPAGNADLGVPARNADPGAPVGNADPGVPACNADPGAPARNADPGAPARNADRGAPACNADPGVPAGNADPGVPARNADPGAPVGNADRGAPARNADPGAPAGNADPGAPAGNADPGVPAGNADPGAPACNADPGAPAGNADPGVPARNADPGAPAGNAYRGAPACNADPGVPARNADPGAPAGNADPGARAGNAYRGAPACNADPGAPACNADPGAPVGNADPGAPARNADPGVPAGSADPGAPVGNAYRGAPAGNAPGVAEHARVAGPVKRKSASKPRTHRQLFGFDISRRRRDVTDRVASEVEDDLATPLKPSEVGHEQKDDICHACMRFNLRKSGHKQTNRISWIACTRCDKWFHQLCVNLKITRKAAANFDFICSSCLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AU18</accession>
    <name>A0A914AU18_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="5"/>
    <dbReference type="RefSeq" id="XP_038066994.1">
        <property type="nucleotide sequence ID" value="XM_038211066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AU18"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211066.1">
        <property type="protein sequence ID" value="XP_038066994.1"/>
        <property type="gene ID" value="LOC119737006"/>
    </dbReference>
    <dbReference type="GeneID" id="119737006"/>
    <dbReference type="OMA" id="HIAHELI"/>
    <dbReference type="OrthoDB" id="8907856at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="11">
        <location>
            <begin position="391"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038066994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="556" mass="62386" checksum="C65FB86D7A6D1624" modified="2023-02-22" version="1">MMSSTSDNNMQQVAAHIAHELIEMKSHSSTAEYLKESSAAQAEILQLQVQDNQKPDVIQLVGDYTAPAMHALQDIIGCNSKTFFQAPCTVELNQGHFSQIPPPGLQEARDLHSNSCHGNQDDASGTSNISQVFVIEGPAPHSLGESLQEDQQDCRQQTPDIVSSPETQTMGGHSQTGVMENSALEEVPAVFYVETLHDANDALRNFEKQTGTKYSAYKSTAGFGNTVYQPDRPHKIYFEERSTDLSGLGIPYDGIPFINIGKKVMDCQYGMDRCRAAKKKYMERQLKDVSRQRRPLAQERTKKIQCRAQIRMKEILKYPDFKVPLDSNSRKDKVRLSKELRDALKNGDAKGEKRIYIKLPCLSDHTGHSLGEAVKEVKPCLSGKQAVKELNTLSWDAFIQRFGNVVERGAVVASAAWSKRPFANIKALHAAFCEFMDSLSQSGKEAIFRCYPNLQIASSAHQTLSNNSSSEFQLTKLDIYSPEESALLVQLNTKYRDNFHFSYIVCGRETTQEEVLADLHARTQNSRDAEILRALQEVKKIAWYRILERVRTVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AVT1</accession>
    <name>A0A914AVT1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038067609.1">
        <property type="nucleotide sequence ID" value="XM_038211681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AVT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038211681.1">
        <property type="protein sequence ID" value="XP_038067609.1"/>
        <property type="gene ID" value="LOC119737370"/>
    </dbReference>
    <dbReference type="GeneID" id="119737370"/>
    <dbReference type="OMA" id="HSAYMAN"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="202"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038067609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="287" mass="31048" checksum="36905778ED65A269" modified="2023-02-22" version="1">MTRSSFPLGIGHDAVIAIRLFLLLVFMHLCHCISGELKALSLIGKNALQSSTYQGHSAYMANNAIDGDLTTFQSTDVVGNSHPWWIVDLGSEYTVARITVTNRHTPEVGGVFIVNTLARAGLHDDSEYELNQPCGVPVTTAESTPASVHEFWCDPPVTARYVSLDKIVTNTEHKLLNVAEVEVDTVDVMEQSTKVNGDFAECKPAWKTPATFTLLYEGGSIANGDPLTTKAARSPMHCALYCLIEADCVSFDYAASGGQCRLYGLNPAQIVIIPNDDVAIFLCGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWA5</accession>
    <name>A0A914AWA5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_038068385.1">
        <property type="nucleotide sequence ID" value="XM_038212457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212457.1">
        <property type="protein sequence ID" value="XP_038068385.1"/>
        <property type="gene ID" value="LOC119737834"/>
    </dbReference>
    <dbReference type="GeneID" id="119737834"/>
    <dbReference type="OMA" id="TEPFHRE"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000151">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="206"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="506" mass="58686" checksum="8FCFE27C96B39221" modified="2023-02-22" version="1">MEQLYLSEKGNDDSVDGTQQKPLDTLLKLFQRDQKKKDEKEKREDEDRERREKNLEEAKKIVIEEDPSLPKAKRILIKEGTANRDQRVKVQGWVHRLRRQGKNLMFIVLRDGTGLIQCVLHDKLCQTYNALILSTESSVSLYGVIKVLPEGKMAPGGHELSCDYWELIGAAPAGGADNLVNEESHIDVQLDQRHMMMRGETLSKIMRVRSTVAQCFREHYFNSGYIEVCPPTTVLTQYESGAFKLDFFGEQAYLTQSSQLYLETALPSLGDVFCISQSYRAEMSRTRRHVAEFTHIEAECPFICFDDLLTRLEDLICDTVDKALASPIGPLIMEFNPDFKPPKRPFRRMDYSEAITYLKEHDIRKDDGTFYEFGEDIPEAPERKMMDQINEPILLCRFPAEIKSFYMQRCPEDRRLTESVDVLMPNVGEIVGGSMRIWDYDELMAAYKSAKIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRMHIRDVCFYPRFIERCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AWZ9</accession>
    <name>A0A914AWZ9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038068223.1">
        <property type="nucleotide sequence ID" value="XM_038212295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AWZ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212295.1">
        <property type="protein sequence ID" value="XP_038068223.1"/>
        <property type="gene ID" value="LOC119737737"/>
    </dbReference>
    <dbReference type="GeneID" id="119737737"/>
    <dbReference type="OMA" id="AIIICIW"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="374" mass="41586" checksum="3AC2DEEB4ACE72A8" modified="2023-02-22" version="1">MALMSMNNTSSIMNITTIEPATLSQSLNPYNVRIGVACVWIIAAVLGLVGNSLVICSVILSKKLRTVTNAFVVNLSLADFWTSLSYPWEAVAVLSHGSWPLATEVPCYIAAVQLYTGLGASLYSLAAIAFNRYMLVTKKSATYSRWYSPRKVSAMIAAIWIIPSFVLFLPQVLGIGIFGYDPQDNTCSDKDGHPRGQEYNLAQSLGLFPVPMIIIISSYTALYIHLKRHFRKQKRKRAQQGSPSQGVDGGTVGELTLSFTVVSESSAMPTNNVAKSNRREISRQQLAITKNLFVVFFIFFLVMSPYFISLAIPSSRKFALYGVTITTLNSCVNPIIYTAKHPQFKLVLRQILRCRYSQIPEPSDWLKSVLSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXL3</accession>
    <name>A0A914AXL3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068437.1">
        <property type="nucleotide sequence ID" value="XM_038212509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXL3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212509.1">
        <property type="protein sequence ID" value="XP_038068437.1"/>
        <property type="gene ID" value="LOC119737874"/>
    </dbReference>
    <dbReference type="GeneID" id="119737874"/>
    <dbReference type="OMA" id="HINANML"/>
    <dbReference type="OrthoDB" id="6363818at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037548151" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="678" mass="76536" checksum="AC1886E5E8AC8B80" modified="2023-02-22" version="1">MDMFAMARVLFLVGVLIGTCQSSTCHAQCDYDHVTARADCSSRNLNCIPVNYPDSLVMDLSHNAMSVLEPNDFNGTFTRLVELYLDYNDISDVTSLLQSTGLGSLKKLSVEHNIVYDLPYSCSLTSLEEMSLDYNSLHYLLMIPFCNNLKKLSADSNEILRVDFHAFFLDSFPFLSFISLRFNEIRNFRWGTDHPYKSSPNVTFLLDHNEITHVVLFVRNYFGSYLDRLSLSHNRLQHVYAELPSKFEIASNGLREFSGFRFFLPPEILMEELDMSNNSFDSLIQPEWAEGLHILNADYNKLANLSSTTLQGFINLTELHLANNRLLFISSTALSQLTKLRSLYLDGNALTSLLGAIFLNQADLVELSITNNQLSELYPDYFLGLDSLERLYLAGNRLVYVHSEMFRQMPFLTTMDFSKNKLKVFDLTNCSLLGNLQNIMLAHNSIHDISYILGHCVNLEVLDLSFNQIQVVPGDSLTGRNRALYRLELEGNPLQCDCRLTGLRDWLRNNPPSGLPRCQGPPQNSGAVVSDLDVHDFICDPPKASLSLAATVLPTMFITLIITLAVVALVICLRRRYRKKDHSTSAAEGVRGASRLTVGFRKTGVPTRSDEGYVDQAVDGDYMTPTPKEDTGEEYEVPTKTARHPYGRHQRHLKVIPSVEMDDAHFYEPVNCGGETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AXW1</accession>
    <name>A0A914AXW1_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038068537.1">
        <property type="nucleotide sequence ID" value="XM_038212609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038068538.1">
        <property type="nucleotide sequence ID" value="XM_038212610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AXW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212609.1">
        <property type="protein sequence ID" value="XP_038068537.1"/>
        <property type="gene ID" value="LOC119737935"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038212610.1">
        <property type="protein sequence ID" value="XP_038068538.1"/>
        <property type="gene ID" value="LOC119737935"/>
    </dbReference>
    <dbReference type="GeneID" id="119737935"/>
    <dbReference type="OMA" id="LEYGMIA"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="496"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="601" mass="65450" checksum="0F2D12AECD77F0BF" modified="2023-02-22" version="1">MEGVNVRGAVQSYCSKLSWQKRFPISIWLPRYRLPFLLHDFIAGLTVALTVLPQGLAYASIAKLPIQYGLYSAYMGCFVYCFLGTSKDISVGPTAIMSLLVATFGKTDPKNPLLHDPAYAVLLAFFAGVVQFMLGFLHLGALTGFISAGVIAGFTSISAITIAFGQVKHILGIHFSSETFLDDLIMTFQHIKETNPWDVVIGICSIVILLALQLLKHREMSWEKDESYTPSRGQLCTWKFLWLIATGRNAVVVVVTALIAWTLQTQGLADKVTVTGPVRQGLPPFQVPDFSKPDLFSVLELGLAMIPLIGFLEAIAIGKSFARQNDYKVEPNQELIALGCCNLAGSFLSAYPVTGSFSRTAINSQSGVKSPAAGVVTGAVVILALSFLTPAFYYIPKSALASVIIVAVLKMVNYKIVLALWKLRKIELLAFAATCISSLFVGVAYGTAIGIAVDLLIMMYYIARPGIKVLEPLSSGQMARPVDVETHVQVRSTAAVVVQLANSVYYPSTEYIVDVLNEQLHEKDYTRPVIVDFSCVSGLDYTIVEGLNDALNDFKKANAELLFACTKPNVKALLQKADLDGMSIHSTVQDALRSLEEKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914AY93</accession>
    <name>A0A914AY93_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038068489.1">
        <property type="nucleotide sequence ID" value="XM_038212561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914AY93"/>
    <dbReference type="EnsemblMetazoa" id="XM_038212561.1">
        <property type="protein sequence ID" value="XP_038068489.1"/>
        <property type="gene ID" value="LOC119737909"/>
    </dbReference>
    <dbReference type="GeneID" id="119737909"/>
    <dbReference type="OrthoDB" id="10063225at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052679">
        <property type="entry name" value="Cell_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35079">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35079:SF1">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038068489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="910" mass="100014" checksum="2A95986FCDA8BDE4" modified="2023-02-22" version="1">MAYNQPSPTASRKSPRSRSLHNSTFLSQSGLNDTLHSTQSLSGRSSIMTYKSTQYPSASAALAAYISDFEGAHPLSKTYHRTVEDLLTPRSVLLRTVDRSLDTGVRDTRAEWRRYVSKKLLDESYSEMVQADLEREKAQSLIESTRHLTSDLSPLPGSSVVTEMESEVSVSTDALLLAPPYPPIRHPPPPRPKDFIPRESLTLKTEALRRIENRRLEERRMQSSRRQGLAAGRSQAEASSRLKPGHVPQFPSDISPVKKLATSSVPSVGRKGHLVNNSGRSPKFENLTNLQTRRSPFKDGSGVGVAPGLQEDQNLSGGSPGDERNPLRRQNLHTDGRRPPPSWIQDLEGSGISGLISGPHPGGRAPPSWIQELDASQLTSLPSRAHAGGRAPPSWIQDLEASGISSRVKSKTQDQRDGGRPPPSWIQDLNSTFTSGIHGSNTTAKHPEYLATHTLGRGRLSTQNRDPLRRSNSASDLITSAVFHDVTATNQPPGLTVRDFDYSEHISRSLEKERLPEDSKRGPTSSRTVKFSENAKPKKTYSYTTDDLISASPTGKVFHLPQRTSRGQYSANAFSNKYSHSNSRHHTLYDDRLASKRSLGAARELFQHEANSARGDAIDLLSSTPKHSVDFDPNFARRSVNGHASKGLTPHSDGGYSVDTFARKMEQTFDDVDGEREDALLERAEKVLDAARASRGKPNPSLTRHHFEESDRREDADRHDNSLLTEEILDGDRPWERNLPTYKPVNPALDSSQDKPHHQQDIVTQFLEDCLRSTSEVKPKLTGGSQPGPVEALKNMLFTLQGMDPDTQSIANDAALVSEKEERQTSSSTETSTSSLLRSKNTVGLANARKQVTDKDTTSSSGSGTNFDEAPGGKSLQRAMEHLSRLKVLVNGGSCHNSHPSSTNAQVMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B0B2</accession>
    <name>A0A914B0B2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038069338.1">
        <property type="nucleotide sequence ID" value="XM_038213410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B0B2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213410.1">
        <property type="protein sequence ID" value="XP_038069338.1"/>
        <property type="gene ID" value="LOC119738509"/>
    </dbReference>
    <dbReference type="GeneID" id="119738509"/>
    <dbReference type="OMA" id="VVILWIN"/>
    <dbReference type="OrthoDB" id="5964776at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="394" mass="44279" checksum="CFD2D5F141653160" modified="2023-02-22" version="1">MFELDLDPLEMEAMNSGESSMYCQNLTVLNKTNEMAARMLLYDATSSGLITIALPIIGTIGCLINASFLFVVFRIRRMRTITNAYLCNLAASDILFLLTATAAGSLQYHSSPVNFDKYQTGIAGCVLFNFLIYTFFFASIALVTLVSLERYYAICSPLKQWLISGKARTAKLLLVTWMISASMAALNVPAFIVLKPLCVDWPDTEDFQDFPDIVGDCKPVTPWFTQVSCVSRMIPFFVAMIGNIYMYSRIILTLKRRFIVNPNDAAASGQAINHVQSVRRQVSAMLIATGTAFFLCQVSTQVYVLLGMVTSLTGIRFFSPQQRVVILWINRMLLYANSTINPIVYNVTNQRYRSAFNTAIIHCDTHMTTRQRGSRRPYMERGDTAQQTIHTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B1B5</accession>
    <name>A0A914B1B5_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038069584.1">
        <property type="nucleotide sequence ID" value="XM_038213656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B1B5"/>
    <dbReference type="EnsemblMetazoa" id="XM_038213656.1">
        <property type="protein sequence ID" value="XP_038069584.1"/>
        <property type="gene ID" value="LOC119738722"/>
    </dbReference>
    <dbReference type="GeneID" id="119738722"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038069584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="108" mass="11840" checksum="003CDC630C8A6882" modified="2023-02-22" version="1">MAAPGEFGVPRVLNSKNRLTLSQNIGDKWEALAIVLDFSDAKIETFRANNQQNQEGQIRTMLTEWVQKNAGKPLVQMLVEAFRASTVNLKTLALAVKAADENGGDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B2E1</accession>
    <name>A0A914B2E1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038070505.1">
        <property type="nucleotide sequence ID" value="XM_038214577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B2E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038214577.1">
        <property type="protein sequence ID" value="XP_038070505.1"/>
        <property type="gene ID" value="LOC119739594"/>
    </dbReference>
    <dbReference type="GeneID" id="119739594"/>
    <dbReference type="OMA" id="NAVFIYF"/>
    <dbReference type="OrthoDB" id="10056199at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037642302" evidence="3">
        <location>
            <begin position="19"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="831" mass="90787" checksum="AEACB0813C8B7882" modified="2023-02-22" version="1">MICILLVLLLSTVGNCQTGDYTTVDAASTTAGVDGYTGKDKLGCNASMSVSDKSVEEFRGLVDDGAIFVYLKLVFVDAEFDDPLSAYLEDIGNVINPLRWVWAKGGRGKLLLSSPFDFNQLSLTTLGTGVYSIGVKIHGCVDADNDDEQNMRMIALLLRDLIKDEGNKTEEDNDNEMLLCLEKQLGKGDFPLPGVLYFPGSSYSMMQASSAFDCWPYDSDTVERVAPTQYWLGWILAGGVILALYSPMALSFFVQKNKPECDSKGIERLSLVSDLPLGLKYVLCFWRNDNFCFASTRWTLFVTIFVLLQYIPVLVSFVTDMEDFMNRSSAFYRVGPINVIVSIVSHVLINLVFIIAAIVLMERFLRPSGQLFMKPLLQERERSSSVDSNNPSDGDGAAAANSGGSDGHDTTSGGRQGSTDSAQGANVEVEESNIAYRHIVMVEAPPHLWPPSTSLDSYQAFFYYMGWRAKMGLDTKAWRFVLVDWLWERVGAPDPGHTVRTFLCVVIFALLYLLYLPFALIFFAFNSLPLLYCMTRCLQTVLSNDVKPTELMFAFLISLASIAWFFKFVATFVYVAELLGYSFMGFVVNAEAVGSIVLVIVIFIGYVVTAITGFYDGYCVLFSNVMKIAEEAQREKKEAQPATAAATARQDGSTGAVRRAPSSQSPSSGSGGTEMPMTVIDDHGRDPAAPLGSADIVQASPGGGTSRPLDTPLIAVNARGIPSLELRLFWLIVDKHRPIRLQVGSTIFQLLVIGVGIGFGMSILAIANSLSQLSTTVSLFSSVIIAGVVPTVLLAVRSPASQDCYNQAKERQIKADIVHYAQKGELKDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B383</accession>
    <name>A0A914B383_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038064502.1">
        <property type="nucleotide sequence ID" value="XM_038208574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038065596.1">
        <property type="nucleotide sequence ID" value="XM_038209668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_038070373.1">
        <property type="nucleotide sequence ID" value="XM_038214445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B383"/>
    <dbReference type="EnsemblMetazoa" id="XM_038208574.1">
        <property type="protein sequence ID" value="XP_038064502.1"/>
        <property type="gene ID" value="LOC119734934"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038209668.1">
        <property type="protein sequence ID" value="XP_038065596.1"/>
        <property type="gene ID" value="LOC119735752"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_038214445.1">
        <property type="protein sequence ID" value="XP_038070373.1"/>
        <property type="gene ID" value="LOC119739472"/>
    </dbReference>
    <dbReference type="GeneID" id="119734934"/>
    <dbReference type="GeneID" id="119735752"/>
    <dbReference type="GeneID" id="119739472"/>
    <dbReference type="OMA" id="RNHEDEH"/>
    <dbReference type="OrthoDB" id="8834613at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="120"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="389" mass="45772" checksum="A32092A717F987C4" modified="2023-02-22" version="1">MAQECERFIRCYFHLGLTYEEILNILLFNHNILISKRTLSRKLRNLGLFRRKYHTDVIDIACFLQQELQQSGNLHGYRWMHLKCIQNGINTDKETVRLLLGILDPDGVEIRARKKLQRRLYQVRGPNYMWHVDSYDKLKPYGICINGCIDGFSRRVLWLDAYTTSSDPAVIAGYYMNTVRSQMGCPRIIRADHGTENTHIRQMQQFLRRSQDDAFAKDKSFMQGTSQNNQRIECWWGMLRKHFTQFWMDLFAQIKEEGHFSGDHLDKSLLQFCFLNMIQGELDTVVKEWNAHRIAPSRNRHGPFGRPLVMHTMPQLYGAENFLVEVQQDEIDVCSSECIFKGRYPCDKDVFDLCSIMMEERLMSVPSTVEEGINLYNSLRRMILDEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B4I2</accession>
    <name>A0A914B4I2_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENND10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038070968.1">
        <property type="nucleotide sequence ID" value="XM_038215040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B4I2"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215040.1">
        <property type="protein sequence ID" value="XP_038070968.1"/>
        <property type="gene ID" value="LOC119739908"/>
    </dbReference>
    <dbReference type="GeneID" id="119739908"/>
    <dbReference type="CTD" id="404636"/>
    <dbReference type="OMA" id="HKDIAMF"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042431">
        <property type="entry name" value="FAM45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544:SF1">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544">
        <property type="entry name" value="PROTEIN FAM45A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038070968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="354" mass="39698" checksum="165E713C4640285D" modified="2023-02-22" version="1">MAALIDLFAAGLMEKDVNSDVLWVWSYPVVTAKQRELIQRKGCLSTNNSAIVPYVYGQHNRQWFYIRTEEVNDAPALAKVKSFSLVLLTRDFNPEKYSLLSKILCQAYMTSGNPTSMLEHYLSVVTKGSCLSEDNGMFQVQDFDMRKAFAAASVKDVINKFEMESILIYTALLLKKRIAVYHSKVEDLLHFVRALPCLVWHRQNWSLLYPYMDLESEDEIQELKSTSSYVAGFTNEAIESRTDLFDLFVNIPSAEITVAPNAKEYFAMGKLHKDIAQVMVSSAQDEAVSNKQTIVDISNKTMELINNLKSLSDSGPDGDGAGKVSIEALRERKMPPATENFLFSLAAAEGLAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6B7</accession>
    <name>A0A914B6B7_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071504.1">
        <property type="nucleotide sequence ID" value="XM_038215576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6B7"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215576.1">
        <property type="protein sequence ID" value="XP_038071504.1"/>
        <property type="gene ID" value="LOC119740308"/>
    </dbReference>
    <dbReference type="GeneID" id="119740308"/>
    <dbReference type="OrthoDB" id="5970330at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="312" mass="35095" checksum="1F8057E48E17FBFB" modified="2023-02-22" version="1">MNSTLITVITYCGAVISGLAVLENLLVIVVLAATSYLRIKYFTFVFNLALADLGFSVMLIAYALNRDHVFSALMQSFLFVAVLMILAVAVNRYLTLTISPPSRYDALVTPCRLAMVCLLLWCFSFALNVPVVLVASKDVRLILAAWFRPPFVLVVWIVTVVLYLIVFRKINSYTSLPTIPSSPVYGTNNPDMTEQSPPRVGQTRRLMITFSIILVTSFICWTPFNIAQIMEYFIKTGQSTISDDTLNNFNTIGAFVYCLSPAINPLIYWWRLDGFRQGFKGLFCCCLLQKPEQLVEEIVDDNEDQQNTEPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B6S3</accession>
    <name>A0A914B6S3_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038071906.1">
        <property type="nucleotide sequence ID" value="XM_038215978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B6S3"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215978.1">
        <property type="protein sequence ID" value="XP_038071906.1"/>
        <property type="gene ID" value="LOC119740616"/>
    </dbReference>
    <dbReference type="GeneID" id="119740616"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF420">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="263" mass="28040" checksum="1D38E4E4E0713792" modified="2023-02-22" version="1">MQRMMKAFNGSGSGDNFTETQSTVLITLILLAGLLMVLGYLWVIVTVARTRRLHTASDSYLASLAVAEIVVAVCGLPAIFILSSSSGFSFASVLFLSWGILFSVLGYFLNAVLIAADKWLRISRPFVYVREMTWAKCTVCLSVVWGLSAAGSLAGAAAHASCLMGDFSNDSVFSSFSVQAIIFSYVIILPCVTSITVFNILIVRIARHQARAIAADLPAAPREMMEGPPGEHQMQPPATSLIPPVPFIARAPGNSPSSSCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B7L9</accession>
    <name>A0A914B7L9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038071969.1">
        <property type="nucleotide sequence ID" value="XM_038216041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B7L9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216041.1">
        <property type="protein sequence ID" value="XP_038071969.1"/>
        <property type="gene ID" value="LOC119740668"/>
    </dbReference>
    <dbReference type="GeneID" id="119740668"/>
    <dbReference type="OMA" id="YVDGHIH"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071267">
        <property type="term" value="P:L-methionine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF1">
        <property type="entry name" value="HCY-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="401" mass="44015" checksum="C029F3D3D1D53511" modified="2023-02-22" version="1">MADAKKPRMEKRGLMERLNAGEIVIGDGGYVFALEKRGYVKAGPWTPEAAVEFPDAVRQLAREFLRAGSDVMQAFTFYGSDDKLENRGNVSQEKHTGAVVNSAACQIAKEVADEGNALVAGGVSQTPNYLSGSGKEAVQEQFRKQAEVFIKNDVDFLIAEYFEHVEEAVWAVEELKKTGKPVAATLCIGPEGDLHGVSAGDCAVQLAKAGADVVGLNCHFGPVKTLEAIRLMKAAMDKEGLKPFLMTQPLGFKTPDVGKQGFIDLPEFPFGLEPRILTRWDCHKYAREAYEIGVRYIGACCGMEPYHVRAIAEELSPERGCTPAGSQKHGMWGDGLRQHTKPWVRARARRDYWENLKPASGRPDCPVLAKPDGWGVTQGDKDLLQKTEATTDAELQELFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B8X1</accession>
    <name>A0A914B8X1_PATMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_038071867.1">
        <property type="nucleotide sequence ID" value="XM_038215939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B8X1"/>
    <dbReference type="EnsemblMetazoa" id="XM_038215939.1">
        <property type="protein sequence ID" value="XP_038071867.1"/>
        <property type="gene ID" value="LOC119740589"/>
    </dbReference>
    <dbReference type="GeneID" id="119740589"/>
    <dbReference type="OMA" id="GVMSVEY"/>
    <dbReference type="OrthoDB" id="10357852at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038071867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="662" mass="73137" checksum="2C8B22390D8CADDB" modified="2023-02-22" version="1">MAAIRIQTGQESPPPTPEPMDIVYNANMVMSSVGDGQWRPMSSISRNGLTTDSSEPENPDVNEEEGKAVFSLRNKSRVSILEADPVSRQESPLRVHGLASSVPRDPPPTRATSTVSHKTTNGVKRRLRLRTAPGKLQCTTELDRAFATMHDRTRVTFEGIRGNTRTTLNDDRVCRPYSVYTVTKQCERLAISPFGGPLNSAAGRYRERYLNKHRPDVIQGTSRGSIKIKFQRFYDNLDLLAINVKRTPYGTLRKPPPKQARKVEEQTKSVPTQLHKYTNERVANLHESMGRHQEGHPSNQSEGKKLGVMSVEYKVAMEVSSNLEKHRRSRPATLPGIPNYIPGRTDAPRLQNQTERRLTPGEMSLKDGISTNLYDQERSKRGPIKAIEKPPRRVKSPPLSKLSRERFLPEAQQRRKEGESWTQLRIGRPVTPPASEYTVFQSASFATTVRPLTAMTSHNGESENTHKTKSAKRDKTNVQSNQENETEKADECIVQKPAPENDSATNDNESDDTKTNDKISENNQSKPSEDLPETSDCSINENAADSEITGQNDETQENSTPLSSTSLIVTVPGDEGAPEADTMAIGEGVVEVMSEDEHADEGASEAETMANEEGGIEVKSAVDGGTCVDEHGAIEDEENTASADPCGSEETSQQEHDKTVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914B9P9</accession>
    <name>A0A914B9P9_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_038072826.1">
        <property type="nucleotide sequence ID" value="XM_038216898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914B9P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_038216898.1">
        <property type="protein sequence ID" value="XP_038072826.1"/>
        <property type="gene ID" value="LOC119741183"/>
    </dbReference>
    <dbReference type="GeneID" id="119741183"/>
    <dbReference type="OMA" id="NIFIYAW"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_038072826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000887568"/>
        </source>
    </evidence>
    <sequence length="346" mass="38093" checksum="CE7C49F87AF528B9" modified="2023-02-22" version="1">MELEGQPENATPGSDGADLAGAQDIAIGVVLWLMSLFGAAGNCLTILAIITDRQLRSQSSSYLIVNLAVADMVVFVVIEPFLAFGTATRTWPFSTPFCASLGVLVNQHMVVSVCSMTAIAVNRYYSVVRRTSYHRVFTGPRTLIMCLATWLLGSALFLPLVASPFYANYSAYYGVCVVTSQDTKLGKAVITLIALNIVVNIVISSVCYLQIYREVRKSRLRVMPQVPLPGSDGQPSEDQPASNGSNQKNGVPARMAIAKQQIHRADVAISINLFIVFAVFCICWTPLAIFIFIQTSVSVQLIPGSVWQTAYKLVLFNSTLNIFIYAWKNRKLRSAYIKLLRCQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A914BA50</accession>
    <name>A0A914BA50_PATMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Patiria miniata</name>
        <name type="common">Bat star</name>
        <name type="synonym">Asterina miniata</name>
        <dbReference type="NCBI Taxonomy" id="46514"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Asterinidae</taxon>
            <taxon>Patiria</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-11" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_038072971.1">
        <property type="nucleotide sequence ID" value="XM_038217043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A914BA50"/>
    <dbReference type="EnsemblMetazoa" id="XM_038217043.1">
        <property type="protein sequence ID" value="XP_038072971.1"/>
        <property type="gene ID" value="LOC119741291"/>
    </dbReference>
    <dbReference type="GeneID" id="119741291"/>
    <dbReference type="OMA" id="LVIMEMC"/>
    <dbReference type="OrthoDB" id="965854at2759"/>
    <dbReference type="Proteomes" id="UP000887568">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keywor
[file cut: first 33554432 bytes kept]
[document cut: first 30640624 of 33424301 characters kept]
